<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBQ3</accession>
    <name>A0AAD2CBQ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1922637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000058">
        <property type="term" value="P:regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039749">
        <property type="entry name" value="NUB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12948:SF3">
        <property type="entry name" value="NEDD8 ULTIMATE BUSTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12948">
        <property type="entry name" value="NEDD8 ULTIMATE BUSTER-1 BS4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1922637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="513" mass="56776" checksum="4047FB0C30371A90" modified="2024-05-29" version="1">MAAPEKVEQLISMGYIESEAEQALDIAGGDLEQAVGFLMLSSSDRGGFTGESTQAAASKQADAFSDYYDKMPPPSQPTTSNLKPPPQYSTPPPRPPAKNSNNLKKPPLQSQPPPPAPVEDTFDALKISGMDFVPGNEIPQRGFGNISVPHMTSFRSTVSDITDMDGMRMSSSIRDDSGGGVDDKKVMELVEMGYPMDEAEQALKVSDGDLDQAVGFLLLEKESRQAFMGDVMDSCQIGSPDPKSQTDGDARERANQFLREEEERERLQQEQIELMRKKEQDILVSGHNHHHHTHEKATKTRPSYTNYQTSVNPTNKNVPKMVVTNQGAYDDGSRPFCTCIAARNFLNGGMVNSTYLNSIVKEGHSLSQRAGTTDEYNVGKVLMRFGRTGDLGLISSTVKVGAFEAENIQGDGSLRRLLANVRNEQLTGWEVVVMEVKNSSFCICLPPKGSANKFWLMDLVGRPEFRTEGAYARVHVSLLQLEESLEYIMKIKGRKMGIEKLDFKLFVVKKFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCR9</accession>
    <name>A0AAD2CCR9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000094">
        <property type="protein sequence ID" value="CAJ1929830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29983" checksum="F819D781753E6F85" modified="2024-05-29" version="1">MGPTDLPKVVQRMLAVKRRTVLNKPLVDREEWLKLVRMERTAYRRALAPQRLIIIEALNIDHEPQKHTPALKEPLGKDENGDPANGSFSYASVIGMALYLCGHSRPDIQFAVSQCVRFIHGFKRSHEKALIRIEQYLKSSVNEGLILRPTDSFDIECHVNADFAGLYSVEDIMDPTCVKSRTGYVISVCGCPVVWVSRLQTDIATATMEAEYHALSMAMRDILPLQRVFKTVAQGLGLSNETATSLKTTVWEDNMGFLKLARLKPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDN9</accession>
    <name>A0AAD2CDN9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000100">
        <property type="protein sequence ID" value="CAJ1929876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDN9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="124" mass="14315" checksum="3AAB08A57C0BF9C4" modified="2024-05-29" version="1">MASTHMLRQTIIVNEGDSPLAYKSKEITNPVMQYVSFINNNFERKRKVEVWNGASVKNVEPLLISIQSFRNLVGEWGINQGRQKKALFKQFLTAEPQMTYQRICDTHGNSVQDFENSVNEFICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDT7</accession>
    <name>A0AAD2CDT7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000136">
        <property type="protein sequence ID" value="CAJ1931269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDT7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="68" mass="8322" checksum="306657C9A0336625" modified="2024-05-29" version="1">MKRMTKNPHYIIIVVLFSSRRYFLDMLYTIYRESMASTRYCHRHCFQIMDHVIYIIGRVAEMKPYILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFI4</accession>
    <name>A0AAD2CFI4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFI4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="199" mass="21908" checksum="526D91EDAF29AF29" modified="2024-05-29" version="1">MAAVICDLIGDICRPICSGVAFGCREVSKSPFLPYLALTFALNTPGVVYALKSLESSCGDLKSWLLPNAIFCLLHMIAAYYVVSKIREPSSLPTTVNENSPLQNATTGFSLMPNGDIQGEENSFQRIKHILLYDKNMAVYILVFVIWLVWLPLGLKRRLENSSCDDITHYVDVSIACGYTFFSLVGVAFTCSLCCLKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGZ8</accession>
    <name>A0AAD2CGZ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGZ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF34">
        <property type="entry name" value="ABC1 ATYPICAL KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="178"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="571" mass="64463" checksum="3BFC7674193876AD" modified="2024-05-29" version="1">MIRRKLASEGNLESRLVRFARLSRLDGKRPFSSESAGSRTSVLYPLLGGSVVLATAGATKYVHDNVGGTEGLTRSLSFYSFAIPKYVEYRYHMYNKSPDHVWDKLDTDTSKTALDKAYELEGFYIKGGQMVAANMGGAFPQIWQDTMSVLQDQVPPQDFTVIKDIVSSELDFDEVFSSFEETPIGSAAIGQVHRATLKNGTPVVVKVRYPNVERILRGDVVTIKMFAQIAQPVHVPALEEIEEQFMTEFDYVQEGQQLENVRKNLRKAGLEGPGKACRVPKPYLHLCTERVLVMEELHGVKLADGLKDEMGIQARREGKTTEQYMSEMKQKERLAKERGEELKGPSSSEYDMYISVLNKQRLVSNTLRKLHNISVGWFPGNKMKVIEDKSALPVNHAKMIDDLFYIHGHEILVDGYFNGDCHPGNIMLLREVDGSPSIGLIDYGQVKKISKETRHLFARLLIALDDDNKEEIVRLMQKAGMKTEKMDPEVLYLYAKVSYDTINDKILQGKHIQLFMEDLESRDPIVQLPTELLMASRCSILLRGLAMALHQNRSAASAWRPIAERVLQTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHZ4</accession>
    <name>A0AAD2CHZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000278">
        <property type="protein sequence ID" value="CAJ1933500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="294" mass="32677" checksum="65773CFE996DB36C" modified="2024-05-29" version="1">MWVWEEFLMAKAAELLGVDDGVSCVVVPYAFLLDHMLEVANKLGVQARAVRSPSICRGMVPDVIKESLPSILLFTVDSFANMMEKSGSFVGQWVEDGKIRRFFIDEVHTPFLEMDFRFRYDSLRKYVPILSEKGAQIVTMSGSLPHGVQTAVTQWLGTTGNLATRVSSLGLTGIAVEVVEPMDKSGWQQFVLDRLQKGHMHIFCATLADCTSMETALYGDGSTELGTHAIVTSQTDEDTRRLVGKRWYNDLLPVLISTTCCLVGNENLKCKTVVVFRHVYNLVSLVQAKERGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK21</accession>
    <name>A0AAD2CK21_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS4356</name>
        <name evidence="6" type="ORF">CYCCA115_LOCUS9611</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK21"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF11">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042440650" description="Beta-lactamase-related domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="4">
        <location>
            <begin position="34"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="4">
        <location>
            <begin position="480"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="4">
        <location>
            <begin position="668"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1935019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1945467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="914" mass="100799" checksum="195C5DC6168643EC" modified="2024-05-29" version="1">MKLNLKVLTLLGIFSSILLGVSTAQQDDALDVAMKAALKSNNVRGASVAYYNENLSTEPILRAYGTTSAADDADYMDIDTVIMIASVSKVMTSTAIYKLAADNVIGLDDNICNSLPDYYDVTACTHPTYKTTPITWRMLMTHTSSMAKDIPTMADGGNAAYGPANAYGGSAVGNPTCPLTDVKGFYRDLMIDKDTKTSVGTYENDINWFDLGEGKIWLNDKPGTKNHYSNLAFGLASALLEHETNTSFATYCRDKIFKKLGMTSTAWHRKDLPPDAHETETVRFENNQFKDEDLFCFVDYASGGLRTNAKDFSLYLKAMLDYGVKLWSKELGEKSLECSEPGKSGSACDQGFGWELMTYDNSPDWLYESAQDFKWKHAAGHAGEEAGSQTQVVFFPEERVYALVFTNTGGNTDQAAQNIMKDLLKAAPSAITQGKALGDIYVADRHSTTKQRPAQRTKEETRPIRNKEGPPRHPRAKDELDDALEAVMEESKVRGAAVAYFNKGLSDAPLFRSYGYASAEADAPRITEDTAFMIASVSKVFTGTAILKLAAQDLIDLDDDICDALPDEYYDESACRNPKYNDTKITWRMLMTHTSSFGREIPGLENGDAPTYGPTGGWGGGAVGNPECPLTDVTGFYRDLLIDKETETSVGTDGTNLNWFDLGEGAVWEDWKPATKNEYSNLATGYAAALLEHVTGTSFDAYCKEHIFDAVGMDSTAWFSEDLPPDVLESQPISYSENTTEWEDMGQYCFIDYASGQLRTTARDMSRFLKVMIDYGDGMLPKGMVKTALECSEPGKSGRDCNQGFSWLLLDKASFAKEDDWLEPVTDLNWDHAAAHDGSELGSQTQVVFFPESNVYALVFINTDGYDDGAAQYMMQELLATAPNVMLQGREKARVHTHKEANVRTHHTGRNDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK41</accession>
    <name>A0AAD2CK41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042015488" evidence="2">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="167" mass="16948" checksum="F8CA174243ADB081" modified="2024-05-29" version="1">MRSSTAAVLLLALLLSANAEAGQWQHSQNRKLSKKSSKKSATVAMASAPVAAPVAAPVMATPASASSISSASSDDTPAAAPVAVVPVAVMPVAATSYGGTPVSQPVAMPVAEITLATVPVAPVVTAGAAAADDDDDLWDDDADDDLWDDDLWDDDLWDDDDSDDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKG1</accession>
    <name>A0AAD2CKG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="103"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="398" mass="44428" checksum="032A84A770967E6F" modified="2024-05-29" version="1">MRDRITLESPDHYDGAAIGRNGNNHNTARTMMMPCHVEFSILDAGKHNNSHNRSGSFSSSCTNSIDFLIEGIDIDDHYDTERKYSREQEQQEPDVSPYSCGKTFIIHKQSKEETLGIELGKATKYGGVFVTKIEANSKFAYTGLKPGMQILSINDRPCPVDFRTVAFIMKETVGDLKISAIDATNKKNMAMAIQNKQAHRQRKQNETKHPATSSQPQTINKEESFGSARTWSPGTSYYASQQSDQRETRESSHGRILFEERSPASPLSSSSKLLASPRALATGGARLVSHWMRSKRYQKIKSDALKKSSGKSSRRLTRRSASTREVQRRMMMESNGVDDDECSTDGLLERIPSALALHDIVQEGLEERAPAKETLLSNATAFNNFTQTDYEAGTLSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKL4</accession>
    <name>A0AAD2CKL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000369">
        <property type="protein sequence ID" value="CAJ1934721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF3">
        <property type="entry name" value="LIPASE LIH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1934721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="480" mass="53889" checksum="4863E961B3B8686E" modified="2024-05-29" version="1">MVIINKVSEPLEGAVMEEVTKGVMLGILAAGKESNNHDNAPPRPTTKPAQSPSWFGSTENPPIETNKNQTFPWDAEAVKLITGSRRDQASKPLASILKEDLNLNLLTEFESSPAADPNAPKEWNTRSWRVEDNTIHGYVAQNDDMVVLAFSSRQSAFDWIADVDTSTAFWKKNLSSMSKEEMSMPSPGVFCSFFGGGGASICQSSSDITVNRYFYQLFLEVWPKIEQYIEVVLRPSGRPRTLHIVGHSLGGAIATLVGCHLILEYDWNQLPHDLVVVTSGSPRTVSPQLKSMIDARRRLFALNTRVYRVVKGADAIITLPPPRSSGGLEHLVDPILITDSGEIGWHLMGEAFDTNVRLLRKALQNAQLSKFVQHHRQDAGEGRDDMDYGLGAPNNSFEYSKLVTRLPKALRDHLPNSYLQPMLNAQGWRYGSIRECFSEESYRQTPDQRQAKARENRAKPANYVPKRFLRHEHPEEEIHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKM0</accession>
    <name>A0AAD2CKM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000369">
        <property type="protein sequence ID" value="CAJ1934736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="60"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="146" mass="16870" checksum="39F8CE7FC8ECF432" modified="2024-05-29" version="1">MELSTDEQIVKVTQLFRNLRRQRSRPSANSASSAGLSSLTPSFISRPSTEIVDHVSPNDVLFGPWLTRPGNRQLRELVIALSDEYNHTDRGEKKNTVSQLVERIQRSGARFLKPSTEHDGKWEVVSNKECAQGYDEKRWYSWRTHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL69</accession>
    <name>A0AAD2CL69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNRLRE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL69"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033679">
        <property type="entry name" value="DNRLRE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042197140" description="DNRLRE domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1937960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="40455" checksum="C3E911C22153C118" modified="2024-05-29" version="1">MADRLGLLWLCVGVASAQTPPVGHIAGNPNLSAGNLCDLSDPSTLVGELSVSHVATLFEGFGSSAASKDYFIAGLTSTGVRRSLLKFDLAGVSFPADVQVLCAEVRLSLDVNLSSSDAAPPEITLHEVTQDWSGNADSQFEGLNGSPAVNGDVTWEFTTYPTTRWANMGGDFAGDPLSRQQKTTAADGAEHEWFGNTKRMHALVNQWIGDSSSNHGLLVKSDEQLDDPIAYNVYHGAEVTTGLAPRLIVIYTAPSLGYPHKVAQGPGSPTGSPTIFDDMLVGIPTDSPTAGLGGAGGSTNGDSPTIGPDNGGSISSDSDSDSEDNAFGFTRESKSNTEYTAVALSVTGIALAAVVASLFGMIPHRAETTEELGEQGGNVIAPQSGAPTELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNJ9</accession>
    <name>A0AAD2CNJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50615" checksum="B061FAAE74DDE575" modified="2024-05-29" version="1">MTITKSNYETIIEMEEFHPLFGDSNGGIQTRQFDATQQLSLPTVTLSAASRRKPEPKRCHMARSLKIFVCLFPLYFYRQINDVSVSTDMFSSPIVRNDYTSVRSIHDLDSQRVAQWCNRRVYECPCQDPLVANPRDSETAWQTKHAKNVQVLTDSMSGSKNGTGYPDVVFYGDGLVAGWNKYPAVFDSFFKVTKGGKFNAIALGIADDRSPNLLWRLQNGEMPDDYTEFSTEPAVMWLMIGSQDLGLTSCAPELVIIGILRIVEELLIRTTTANVVINGILPRTFNRDGFVNKGGLLNPSTIGIPTGIGTTAGSNENGASGVFNSAGSTDGTTVASTTKSLWQDIQVVNEELKLYARYRHRVSYFDHNKKLFEDPSATGKDLRIDPRYMEDHFHLTQKGYQQWGAAIAKRLSKLIVLPYRNMPDGSARQKAKTEEGYQEDSYFGDDKDEDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNU0</accession>
    <name>A0AAD2CNU0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000759">
        <property type="protein sequence ID" value="CAJ1938733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNU0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="183" mass="19669" checksum="0E08E08F6DE75030" modified="2024-05-29" version="1" fragment="single">MQEVRENSNAQGSTVGNNVSRSSKRRQVRMALLCCFLILAAAAGAVVAVLKLKDPEDIIDTSSNNNNKTTPHVTSSAPTELISSNPTHRPSLPGSRTTSAPTPNPSLGPTYRPSSSEPSRSPTSSPTRPCIQSDAELSDAVRDWLQDSQIKTIVENQYGSIGDWCFGPSVTSMESLFRSQSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPB8</accession>
    <name>A0AAD2CPB8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPB8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="210" mass="23944" checksum="BC865463336790E3" modified="2024-05-29" version="1">MPDQHADIEESDSQDISEIRRKALALLERCGGNSDEEIDYDDEDDEDDEETNAKDSKSPEMKHIHSSELLKEKDDGIEEGKGGRRSPRRRKRNGDASSGDTNDDDDDDEERSYGDEELDPLVKAVRELSYSLETEMVERQDSTVSRLTDMNGGITGSICWCCKCCCCQRWSRRTQCLVVWIIVIVSLAVSYYLFLTQYPHLKRRQHAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ39</accession>
    <name>A0AAD2CQ39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="849"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1251"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1292"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1486"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1219"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1307"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1353"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1385"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1409"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1488"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1521" mass="169053" checksum="A0F8BD2A34A24140" modified="2024-05-29" version="1">MTDPTTTSLTTTSPTKESSRRTYASYSASINININITKEEDGTPSTAATNDDDNNADADNNNHDSPSSSAATATNKKDLSVLEMTRDLFQSQESKSAGKSSGGIDWSLDSDGEDNNNNDDIDNENENPAQENDGAKEESEKETELLATQPSVTKPTIANDSDTASMSSGDNDDDEDDNDDEQRQEEETPETSDEKEVSKGEDASETVESEPSSELVAATSEDSNAATNALKAKDSASSSPNKEQPESDSDDDATVAMDLDDEDDEATRSSSKPPSSSLFDVDLSDEDDDEDNGNAENDASSDDKEEESSKLAKRGRAKRKQKQKQNPVKKTTIPEDSESEQEFDDAMPPAAAAAAEKEQPPPSEEDVAEDADTEDNGQRRSRRTPKKRNLEFVPTEPSPRKTSSTSKKSKDNQKKKKNKKKAGQEPAHDSLITSTDYLFLHADKTTVTVKDILKALEAEYDCKLSKSTRKFVRSHLVSLMSGEVEPSVSLDDNENDDASNKPSNEEEENVGEDEVDSNDDEEDQISEQGDVESEFEADEEDNDDDFEAPKSKTKKSKNKKSSSSPKSKKVTKNKKSKDSSRSKPKRPNQRKAAKAAKLVEAMRLRKKRMEELRVRNEEMQLNQTKEDQARAEKIAAKLDTNTDELRMQRLEDRLDLLGKLDQRRIVVLLDEDIVLGDLVKKEETKNENSENAESTDIKDEKDGDASKLAEEAKSSEEESSDDEDLVIVGATKRIKPMAPLSIHVKASAIDVLNRIKSPDRKQQQSKQRQQQQKQLAPANNVRARSALRNSLKQKQRAMGNTWLARELGYKTEQEHLKDCEEAANKKRGLTILREQQRIQANERKQLRERLIFQEAPADDDDEENEANLEESSASAAKPEEEDEEMQMAKEIEQEHADKISPSTTDDSPAVSESGPLKNTESQESVDSLVQDTEFRDKTPIPDEEDGPEDFSPDFSQEDEAQPLESPQLPGLPDTETQDEVQRLETQPPGPAELSVEHGTQEETQRLETQIPPSAQKMPPPAAVVREVTAEPGKELSQLSDGVDKESFQREVAGTTEASEESADIKPQVAEGKDSEDSEDDGELEFVEEKQEKPKQDRNAGWKLMLQKEAEKYKKQKRRKGGNDLVEQEAEEEEEEEVAGLEDFGFSIKKKRNGDDEDEDPDSLKVDDDDLEHVVDDVSDGEGDEEAGRIARKKQEQREEKERHKDMIRRMREGYDGRRGGIAGSGVGARGMHRFDQLVAADNREDAKRLGLLNADELDSDDENNENKKGDVDDEDDEAKLLDSMLKDRFLHRSNVELENFSDDEDEGDKKESEETKGVSTEEMTEASEERTQERLAKRFAKRARMCRLEEQYADSQEFSQQRMIDEDESMKKELSQMKNGLVRNRSTSSRSSISSNSNLGSTILKRQRSTSSNLSTSLKRQKSTGSSFGGSFLDKGGSLSVALRGNRSHMKRKTSFLGGDKAGDSKDQGSSVVKNVALSHVVFKADSSRSSFSNSGSSLNGKRKLGSAGGSFFRRATGKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQF0</accession>
    <name>A0AAD2CQF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000835">
        <property type="protein sequence ID" value="CAJ1939731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQF0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62662" checksum="86BAF458419F080A" modified="2024-05-29" version="1">MWMMLNNKVKFGGNVSVRARGKKPLICFGQDECIMKQYLFTDKAWVTPEGIRPLTPKDEGMGVMVSEFVSREFGFGYHNPNLSPELKQTSGLALSEHQRQIVNSFRRQPGNNEYRDKEAAHHVHGRNGIKKKDLPKDSSPFVQLFEYGKNLKGYWTYEWMVIQLEDCIDVLQALHGNEYDYLFMFDHSNGHDKQRPDGLNANAMNKGYGGSQPRMREVAIESEDQLGPFNPPGKLKVGETQHLVFDQPDDDGPCWMNDEEKRASKEDCAESTNEQPMFRYHFKKGELAEKLQALGKAINGNKADLQKRCTDNGIAISEMRMKIKQGWENKPKGMLQVLWERGFIDTAVPKSELWKKYPEKGQKDNLGLVMPGTALKEMVADLPDFQDEKTLLQYHAEGRSTAGCQIMFIRSPKCHPEIAGEGIEYDWAGIKSYYRRSDLASKKTLEAFKALVKESMESVQFNHRASFSARAREYMLAYDVLEEWNNLPEELKNGDPEKEKLPKTSAQFLDRIVNCRRKRHRDVGADEGWVNLIMNAMKKREVIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR11</accession>
    <name>A0AAD2CR11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR11"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="143" mass="16238" checksum="E4F794CCC2C7556D" modified="2024-05-29" version="1">MRQKANQKAQQGALRGKQDDQTLSKQQAQLEEQQKKIGDEEERQRKEDGELTRQKEGQEILLKQRLEAKQQAEYQELREELVKAEEKIASIANVVDGEANLDLASSKLPETLDGEDNEGQIEKVKVLVEEAKAKINKLESVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR19</accession>
    <name>A0AAD2CR19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS8369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042083691" description="Carboxypeptidase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1943297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="77125" checksum="05C5884E6B34FF6E" modified="2024-05-29" version="1">MFHSIKLFLLWQLPFALAVRRIPDGHWGTFKTQLLAAKKNHHRQTSAQEEEGGGNKAHRRVTVDIPASPDGHLVTELPLLDKAKFPTSHWAGLLPVNDDGQNYFFYWLFAPDDGSGQDMDFSDRSIPLVIWLNGGPACSSMDGLWLENGPFRLTENADDSWSIELDEYSWHKSPAFVLYIDQPVGTGISFTTNKKYPSNDEQVNMDFYYFLNQFLTFHKDKFLDESSQTLNRPLYFSGESHAGHYIPSMMNYIQKQNAKSPSLQIPLSGAAIGNGWIDPPVQYSAHEAAYGKGIIGLSQKRALEDDEKRCQQDLAKGKYVSKHCYALLDAVIDNSQGHGSLYHISQYDARKTEKVSGARDFPKGHKDVEAYLGGGHQSSTPVLANLKDQVLKAIHATPSAEAGQEYEECTDPPYNALKHQDGLGVTHDVVDLLNNDVRMMFFNGIEDMICNHVGNEIAVENFEWKLQKEYQLAPRYGWRSPSTQMLAGFMKEHENLMYLKVKDSGHMVPMDLPDVALDLIRTLIYNKSFEDYEQRISRMTAPDGDSDGTNCPICLDSSDDDEDEDSDEDSDEESDDDDAEGTQKKKTCPKCPACSSKSKIAKKGTPELPQTFKDWATTSPTTLIGGSALIAWALAFCMYMACFRRKDRGPKYRPANRYDMEMTSGGYSDKAQADLDPYEEEPIEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRF2</accession>
    <name>A0AAD2CRF2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000968">
        <property type="protein sequence ID" value="CAJ1940859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="128" mass="14141" checksum="C5828DAA78D843AC" modified="2024-05-29" version="1">MGNNSGQKRKQMRTDPPLTFMTVGSFAAMGQAQKLDFPVNEALAVMHFPIGLNRGDTANLKGIFDTGGCCNIGEKAYHLAIAKQHPQLVKQVYNFPKIHYAPIKIGGIKDSVNIKAIIEYYFPFANIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS24</accession>
    <name>A0AAD2CS24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">YEATS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS8122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16910">
        <property type="entry name" value="YEATS_TFIID14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1942788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="267" mass="29878" checksum="47F62FD370279AAD" modified="2024-05-29" version="1">MATTKQASTPEAASAGGEDPKNNNSNSTRLSKTTACLPIVHGSIAFYLGKKADEFQTHEWTLFVRGPHHEDLSPAIAKVVFQLHPSFAQPVRELTQPPFEVTERGWGEFEAQIRIVWTDPSEKATVINHALKLYPPGSPPNVLPKDENAPPVIAESYDEVVFTDPNENFFRQLLHIPKAPKVESSQQEWLTECFADETDFLTLAGAQKFLEEELETVKERFQVVSEEYEVVDREYTAAMQKHQQQQAANKKSKGGGGKRTTKKARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSG6</accession>
    <name>A0AAD2CSG6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS9221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000014">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31469">
        <property type="entry name" value="OS07G0633600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31469:SF8">
        <property type="entry name" value="OS07G0641000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1945077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="60506" checksum="A345F068EC07EAA4" modified="2024-05-29" version="1">MTLMMHQDHLSSHPSSKHSSFVDKHIQTTTKKEVTSSNQKGDDGLHSVAGLDCSAHGGPSNDLAQEMVYWKNLPNDESYVSPFRDPGQRRYLTFEPDGGGWNNIRMSMETVLAMAIATGRVLVLTPSQKMYLLGGTDFSFADFFPLHSIAKEHPGLEIITMKQFLEETHGKLKNTETNEISYPPHNTTEWDGNTGSVKSELNPWLRTIAYNADWNPDHCLAAFPSSKDFTSEATLTSTFEQVNSEKVNFEQFFNQPTPVNGTIHDRMAEFIAGRSAMCMYDNQVQREQVIHFAGKAKLAGGRLLVHFYAFLFFSDWKADLWMKRFVRDHVRYIDDIQCAAARIVAAVREDARKRISDNADGIFDSFHIRRGDFQYKKTRVEASEILKAAENEIPKGTFVYVATDERDKKFFADMEGYWNVVYMDNYMHLLDGVDKNFFGMIDQLVASRGRTFFGCWFSTFTGYITRLRGYHSQNAQAEGSDMGLLPNSYYYAVVEHKTKLHDFWPVKKLYYAREYPVSWRNIDFDAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSL2</accession>
    <name>A0AAD2CSL2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSL2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="222" mass="25189" checksum="69FE1CA808F2E0FF" modified="2024-05-29" version="1">MIGSSIITKRIRNVRCHSLLASAWNSSHRQLEPESICRQNNNSQTNPIARNHSSNGNSSSIDNDSNDFQIPKPTWSIRDLDLTAKRPPLPEEELDRLSKLALIDFKAMGPKDQESLGQDLANMLHMIDQVTQYDDDEDNDNDNSDSGNDDENIQAAAQIYDLVRGGLTKAPLRKSLEQDHLQDKDEEIAKDVWEKMLQPKTKRMGGRHEYFAIQTKTEETSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSR6</accession>
    <name>A0AAD2CSR6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001264">
        <property type="protein sequence ID" value="CAJ1944870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="98" mass="11003" checksum="99A9BD124D8C6C9D" modified="2024-05-29" version="1">MPRPRGVLKNYLVVKEVGDVKSGNGRSIDELRGVLLYCPTKDMLADFFSKPQQGSLYARFRDMVMGITPVPPVEDPSLTCPTSQERPGNRNLAYNSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTL6</accession>
    <name>A0AAD2CTL6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTL6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041922325" description="Fatty acid desaturase domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="154"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1944365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="442" mass="49975" checksum="182154E9AC8CD370" modified="2024-05-29" version="1">MRIAFRSILVLNVIASAAAFSSSSNNAPRIHVTRSVASPRRRVSTNSMALGSTVLQPPGTVQGDIDQQDSTTTTTADDIESTVITTTTTTQDPPRLGEVVKMLPKNTFEIDTATSLFYFAVDFVAVAATMGCLSTVVHSELYHSAPILLQGMMVAPLQVLTGFAMWCMWCIGHDAGHSVVSKNKKINRFVGEMAHSMICLTPFLPWAKSHKKHHLGHNHLTKDYSHQWFIREESDDLHPLIKLSYKTRNLQLPILYLVYLLAGVPDGGHVFFYGRMWEGASKDEKKDGLISVAVSLATAATLWLNLGLADFTVVCMIPWCVMSFWLFMVTYLQHHSDDGKLYTDDTFTFERGAFETVDRNYGTWINRLSHHMMDGHVIHHLFFEKVPHYRLEDATTALRKGLDESGQSKFYKFIETPNFTQEIVKQFNDNWFFVNEKQVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU98</accession>
    <name>A0AAD2CU98_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="159" mass="18498" checksum="CEF290D542FD7812" modified="2024-05-29" version="1">MKYKPQTFRKGRLAAFYESREYLTDEDVRDERYTERTQQDSPPERPNRSYRRRRKQRESSRRNEDAETMITSSNLFKLGSAGLSIAIDMVLTAFDPCGALQDIIPDPPRHEDDPLNESRQNRKNQPEEIHLERTLTVPYADEKGCEDATLISGLTDVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUQ7</accession>
    <name>A0AAD2CUQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Copia protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001350">
        <property type="protein sequence ID" value="CAJ1945322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14986" checksum="8A31536A9C8494B8" modified="2024-05-29" version="1">MGTGAVQAITRKQKLNCDSSTHAELIGVHDAMSNVLWTRLFMEEQGYPIEKNILYQDNKSSILLETNGRSSAGKRSRALNIRYFFVTDQVELGNITIEHMPTDEMWADYMTKPLQGKKFRKFRAVIQGDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWZ8</accession>
    <name>A0AAD2CWZ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000846">
        <property type="protein sequence ID" value="CAJ1939797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWZ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00139">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="316"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1939797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="867" mass="96746" checksum="8EC0844E44C8F4F1" modified="2024-05-29" version="1">MSSAPLRVEEKRLESTGDLRDTKNFDHRGTADNGKGFDYRLESDIFANDNNDVDKDGGIELGYLPPDQRPGIPGELLAHLVDPEIDDDTEAGEALRANANVKVGKVGKAARGLNAQSVRRLVKRATLRGNSGNKRGKPPRIPPGITTESSGDFDIEHGDFNEDIDDGQGSLFKVEDLDASIDDVAELASLSSDETSGGGLPAAGRDSHDHQDADSLKLEQRNPDVKSERSSVANGGGIERVSSKQAKEASPGEEAEDIPVEVVAATMETGRKLMGAIDPHNMLQLQRWRRKNRRGNRKTRKSYVKGKVIDGRHELYTLSIAVMLGVRTSIAKTNTIIASTTRANALTAQDFMAEEKYEFAPKGSDITPPHKLSHTFKFKDYAPLAFAYLRRMFGVNEFDFLLSVCGNANFIEFISNAKSGQFFFYSSDGKYMIKTMTNAESKFLRRILPHYFRHCVQNPNTLITKFLGMYRVKLYHLRRNVKFVIMNSVYYTDKSLQIFYDLKGSEIGREAKPGQDVLKDNDLRKILPEQAFSFHPDVRKRVRQQVVSDCSFLSRMQIMDYSMLIGIHHIPPRQGNNRGIHSESGFRASGIKNEPKLPARVSKGQGVDSESAAAASLNGDCKDPSISAPKQGNAESSKGATKEFHEASSKNYEYPLDEDDDCSYLEGSMPSGMKSPSPSGAKIQQHPALVDVELKKEQTIEQIYWPFHRFYDINGLRRMQPRQAADEKGDQLAKAWKIPDFMPPLSNRKDGGLMMDTSGIGGPGIFHGPKGDRPHEGKIFFMGIIDILQQYNARKRVETSYRKMENSEGLEPSCVSPDDYADRFITFFDQYSQTARPKNAKNEEKTEIEATIIDKNMVNAVRIDVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXV9</accession>
    <name>A0AAD2CXV9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXV9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF271">
        <property type="entry name" value="MYB DNA BINDING PROTEIN_ TRANSCRIPTION FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="406"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="411"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="461"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="466"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="541" mass="60263" checksum="ACFEEAFAA1F4A2F7" modified="2024-05-29" version="1">MKSLSPDTLPLRPAKKQKMSSIETSLPIHGTHLDTPLRGGSNTNNNSRLVTPSFAEQNKDKETNTGTEFGSSLERLPPISMKAIAMVSNKKSIQQNKANKISQAQKENLIPNRLLSPRNSAKDTSRDKLKAVLQRNGQNVTGTVQVLLTRVADGEAHGKLGLCPRCKGGKLKICMDNSEFVYCSRKTLCGFQCVAHHAPRAGPWTCVSFDDDDDNDDATNHEAPSATTTTSAGLSTGQQTGDDNKKILSILPPTPYWNAQHGGAHPMQQGFGPPAMYPFYYPAHHFGFPHHQHRQPLYPLYMGHPSLPPPQQVPGPPDIYRTPPQRTPNSDGVKQNKDTKVHEKRSFPLPNPAHFPDRGAASLQRHEAGARKNENHKTSHSICNYTPAQVAMATEAAKNVLEARQQGETAKQPWTAQEDEVVRKAVVSSRCNNFNAWTTLAPFLPGRKGKQIRDRWVNHLNPRLLHTPFDKEEDLRLWKAVTDFGTSWKEISVRHFYSKRSENAIKNRWHSAPFQRFIALTFGPDKYEGAIAKLKKGSKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYI9</accession>
    <name>A0AAD2CYI9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001513">
        <property type="protein sequence ID" value="CAJ1945787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYI9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="194" mass="21108" checksum="BFF129888E840017" modified="2024-05-29" version="1">MNAAALKAHKLSLDNGRVYKWKNVSAHDDIQAMIAEGYKKPPPKVPTKKKGDPTPPDDDNSKSLPPFICHFKQPASEGGATYLVGDTKKYKNTTWYFCDRPNHRERVKWHTHKATKCCTRLKWKEDNNNTTNDDGTAAAGTETEPTDDSTTTGGGAPSRNLQALLANAMSMVASGNDKLANFLGEAMAAASANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBY4</accession>
    <name>A0AAD2FBY4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1906623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBY4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042153923" description="Thioredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1906623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="186" mass="20601" checksum="6B0154E35906DA4E" modified="2024-05-29" version="1">MKTTLLGIVVALLSASGVSASGAVELTKENFDEKTSGKNAFVKFLAPWPDWDKLGEEYAASSSVVIGDADCTESGEALCTQFEVRGYPTIKYFVDGDKKGEDYSGGRDYDSLKKFVEDKLEVKCDVKDPTECSDKEKKYITKMEAKSSADRVAQIARLEKMAGDKMKGDLKQWLHQRLHILRALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC32</accession>
    <name>A0AAD2FC32_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC32"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="560" mass="65130" checksum="7E8F46F5E6ED786C" modified="2024-05-29" version="1">MPQELKRLDPDYLPFITKKWVEPENNCQDYVQFLLEYWASAVLGVAMMGIGVSMKLVPSTAIVRFWMSFVQPIARLGTIASIHQFQGQIFKLLRSQQPKPIGFFPWAMRFLVSRTVAVTPLVVSFDLARAFFHLQRDGLVALYMSIVALFVGTVVRMDQKGRDGFQMLEKRSSWTKVLHSFAVVAFWTKPLGNLRQTLRRSQFSFWKYVPKRSYDWLTLCASSSVGLLALLGPWIHLGFLFDQFRIVYTHDLSLSVSSQVFKEQIGNESEMEQRMKWRYRIEWREEKRLKPLLKEWISGLEYWLFIKGTVREKLENERIEKLKADLKKGNMVWEKVHADSFPMSNRQRWKTDAMDRIAKKHQEDYDNNTFEDPLGVAVQQALGIGLGFNFDHSRPLEPGEKPSIRRLQARAAKSAVRRVQELYNAEAASEKLDQIEDPDERDRMAKAFREKTEIDIKYLANRLTELIPNSYSGEFDDFGEIEQFRDTRRYKRASSHEYTFENLVDTESLVGFKTPTSADIRVDGSEKDSSSRNPIKEFESSLDHLENKDSDDSDESMILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCA2</accession>
    <name>A0AAD2FCA2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16187</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS24221</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS825</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1918760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002480">
        <property type="protein sequence ID" value="CAJ1970199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1918760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1970199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2005" mass="226151" checksum="478391A5D4672EDE" modified="2024-05-29" version="1">MQTFPPRTLDAILQVGRSALTSVKDLPLDPIKEKLLLSNYFHTHNASACKNILLSQAHGFAYFDGADGTLRQVICPKQVGPNLYWASANDRYESPTPVAFSLDALGSSVISIARDELARECKARHIQDTQYSPHTALAPDSANPPEDIYWPSGDGVFTEVKKFFPIYPGATIPTNLKLSSAPPADLDTFHPQFQLWYEAMKYLHDHNESQSIHSHDHIFSDDTIPTDRFPSSDLATHLTYSTSDVSAFAAEADTYKNLFEEFKRHSALSTLASTTHVATHEVPAAPLPAGAPFDSELFAQIMANALKGVNASTKEKDLARTSASAKDSYRLLFGRVKSVVQLDGSTVKELHPSVLSDDFETFLEIGSIKEALRHLHDTFAHITDTLTTRNNYDRNVDFDIALFQHATVTALKTCSFGFKPLTMHPHEATSLLSLLAWLPPNKHDVKYTTFLAEGRDIIRQEAMEEDKSKQAAKKTDIFVHGDISSVEALIKMLANFFAFAKYCVKDFTFDDPPLIVTLLEDFMDALHTPTAKDWIRWNDKVPHLPLCLLLEMNQILQIVVGVSKNKTTLSKLRNGQPITIDTFVNAFNGVESAIGHLNMSITMGNLGPYATCPNLHTILHGKPNPAPKREGPTTRERPDPTKRARPQPLGSHPGYLTYDGPGRLPIAPFKCKHPITGKQAAFCSHFLFANYHCNRPRCHNIHYTKQFAATMSPTETQSFDKFIEKTPGVTRTAPKPHVPQCSTCIVRTPSSMIRNPINNSLSPPHPSRTTSTSTQPTGTLSNAPSHTPSSSPPSASSPDSPYPRYTDAEQEKFGERLEVAIQGRSSIPSTTKRDREAWATTKLPSPVFLAVNSPHGKDSVDRWFSTQHKFEHTWIFLLKSRYLSPTDMATLFQVCPSIHLLSLLLDEHRFVDFRPLRQPIPTHLPPDVAMHRWSRMFTACLLHYDLSIPTAVRFVGNIHTGAHRDWPTLEPILREAKVDPLLITQLKRIFLDGAPNYVTAESSDDNLRTFIAYGNHKTVYDDVKKTKSAVEKDVLRNYLLAANPALLPYIRDAHTTPLGLVDASHEYRKPRIIFDATHHPSLAAMAVNDFTSKDTEPDICFPRSFPNFLIWIYNLRITYPNEEIYICDDDVSGAFRHVKWNPNVVGMHMFMLFGFLFFCTGLSFGDNTSPAQWEVVALVRQQLAQSLWYAAATTIPRVAKYLPTLSLAPLPTPSDIAAFTPAEPDSKNPGVLQPDGTRKSPTFDHHVDDCLYADVALFLRQTISASVLALYILLGYPNTSNGIRDCISWEKFANTFSHERKTIGWVVNSRQLTVSLPPIKRDRLLKLLSETLANPKLSLRDIAILLGHVSTATTVCRWMRCSYFNLQRVLSQFLRSRHQSIKHYMKRNDKVQIISDQLPPALSYRLASLIGKEAATFLWNANKRFHLDASVTRELRAIQHSLKTETWKIYIPQMIPRDPHFTSFGDASFIGGGAYSEELLFWFRIVWSPDIVAGTKLKSSNPNYVHINSLEFLVAFLQEVATVVRLEGTSHAHAGLVHQFPNGFPHFPVLLNRTDNTPTEKWMNDARTNSPFARLLVDLHGQLLKRSPLTSLSDHVPDISHFTLDEKLRLFPAKSRTLLRPALLSILQSKAGAADDPRKFGTLRSRRLHFLKFCYDMNLRDDYLMNGPDFPHERRVATFALYTVALATGRTLQGQYIKSATIKQYLHAAASFICLFTGRDPRYNNPSDTKMSPDIHATLAEVERHEKVPNKLEPYTLDMQQHLEQHNLDTKAHHDGIWKTCEDWNSIGLLDGHRLSEYAQTSTNKNIGDQATFDGISIAFCVEDVTCFDKFKRKVSIEEFLQNPDRVWRIKMRFSHQKNGNHGEEKLFIRSEKSPLRCYIRRMHSILSRFDRLIGIKTTNVPLAVYQDGARVLFLHDAEITRVMRHVACSLYNLDPQQDKIKYSSHSIRVGACVLLHTSGATTDQIKFLLRWKSDAFMAYLRNVAHLCMQQNDAITMIDATTFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCB6</accession>
    <name>A0AAD2FCB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1910019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1910019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="409" mass="43520" checksum="76F341D796D0BCD3" modified="2024-05-29" version="1">MSVAMVPMSDEFGYTDTLKGSISSLFSVGYGLAIIPSGLLLASISPRILMAAGIALWSAGTLATPFAAAHSNMAVLLSARALVGASESVVVPTVQRFLSSWIPTDKKGIAVAVVFSGFQCGTILAYSISPSVIDAFDGDWRSLFYLYGSLGLGFLIPWLALSRDEPANIAQTKQLPPSGSIAKSEVSALEQAKETFQSAPWKDFVRSKGVWGMFFAHAANNWGLYNNLSWTPIFYNEQYGLNVKESAILLVVPSIVGAIGGLSAGSIADKMIQNMEVETVEEVTKVRKLFQGIGLFGPALCLGILSLNIPEKPWVAQALLAGTVGMQSFNAAGYGAANQEKAGEKWTGLLYSITSLPSVIIGTGSVYLTGRLLDATEQNWSYVFGINAVVFALGATAFVTLYDSKKEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEN1</accession>
    <name>A0AAD2FEN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="279"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="361"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="455" mass="50167" checksum="D69207AD54E0C8E1" modified="2024-05-29" version="1">MSERNQGNEHANGLEALHSLYGSTQPTKHQLHLSLANCLNSGVGAAGNPHQQHQQHQQQLQQLQLLQSLMRQQPIPKHQWNQPLTHPFGQQPTRSFMMPANNAKNAGHLPTSLAALPSDLQSQLLRSLANPPSPSPSPSPSPSPSPSPPPPPPPPISSSQNADLRVALENQSILERATALNEIEIRRALAAGGQEQHQCFRTGNNGTTSSHQSPSRVYIEVDSVARPMPPISDEANTRSDDSAPDQSQSDRTQSLCPPLLPCFAVGEQQDGVRDLRMIQDSSWETRFQELVQFKQEHGHCNVPRRYKGNPKLGVWVCSIRQQMTRGTLNKAKVERLDAIGFQWRISVIKGGQINPQIAKNRQWVESFRLLASIKDRTGTCSVPASSNRKLTKWVSKQRKEMNQGKLSTDKQEKLNSIGFHWKPSIRGLAPSDDGTSYCAKPISHCGSIGGASVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFX4</accession>
    <name>A0AAD2FFX4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="872"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1924694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="966" mass="101591" checksum="9CC63F2CBE5D2FCC" modified="2024-05-29" version="1">MRVNFAGQIVNDQDKSTTILVDRPQAEEIMGVENEDNDSVAKPPTVPERSDDDSVNINQTLGGEDDDTTKAREMTKDGVPNSSGESTVPPLPPTKASRHQTGGPHKKDSLQTVNTSNPPPPVEGELERNQYLQPAPGAVVVHGTELLNAQPVEEEDLEIQRPVPMETVSAVPIEDEKAKTSNERGCPIKFILLGLLVAAVVLAAGLIIGLRKNETSTKTLLFATNSPTPIGLTEAPSSSPTYYLEFGPPSPEECRNIANGNPLMNQEDQILRNFEIQLDVSFSQNFTTMDTQLLSLLDDAMQRKLATSLAGCGEVDYQGESRKLRRRLLRKNVVSNAVFRTTFRDSDEPCLPNSPVFCYRSVATVELYLKGKERINKLLGLITNAFDHESLVNTLGLDPPFSSVIFAAIKSTDPTESPTQAPTFQDSDAEDDQLDDFLLGDDGMDDFLLDDDGMGDDGMDDFLLDDDGMGDDGMDDFLLDDDGMDSNGTDDFLLDDGVMGDDGTDDFLLDDDGTDDSLLDDTTGDDAVGGIGDDAMGDDFMLVDDNVMDDFLLEDDRLDDDGIDDFTEGDDITGDDTVGGIGDDAAVDDVTGDDVLLNDDGIDGFTGDDATGDDWGADDFLLNDVTGDDTVGGIGDDATADDATGDDISPGDDGTDDFLLDDDFMGDDGIDDFLLEDDGIDDIIGDDALFGDDDAVQGAGVDDVTTGGESTDDVAVDDAVGGDDGTDDVALDDEIGGSVGTDDITVDDAPGQDDVPADDAFRQDDATGGVALDDDVGQDDTVDPATGDSGPAKAPVTTSLDPTITPFSAAPITIPVDPTVSPTPTPTKTTMAPSSATPITIPVDPTLSPTSTPTKITMAPSSAAPITTPVDATISPTPAPTKTTIAPSSAAPITTPADPTISPTPAPTKMPTAPPTSRPTAGEDQEDDLIDVDDFAGDDLGVGGVDDFFDADDDFLTGGDDDDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHQ0</accession>
    <name>A0AAD2FHQ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS2948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010487">
        <property type="term" value="F:thermospermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042039518" description="PABS domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="6">
        <location>
            <begin position="404"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1932661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1201" mass="136393" checksum="1C0AD6703D7FC887" modified="2024-05-29" version="1">MMRILSFVVLSLVQIWAHAYSSERNAEAYLIDIVEWVSSHKDGFVNQKAELRLLNLDDDDDDNEPLLGIFAKAEIAKDEVITQIPWEMIVKGGARSLLLGDSSSSSSSSSSSFCNLVQTLANELKLGKRSKYAPYVLHLRSLRNGQIPSAWSVEGKYLLTQILGGDDQQLPPGSITQILEEEWYAACGGDRTDAVMTKAAELVIQREDQGFMVPLYDLVEHRNGHHTNTKTRVKEGIYHQTVASRTIKAGEQLYKSHDLCEGCNEEAIEQGYGTAGEPSQGQEEGVIQVTWHPSIKFDPIGKSYVQRRFRKELRRMFRVKNTLLKSKRELIPKHEWDAIWQYYDTIKTALLLAMHSLIDPKSDIMNTCSRTDQSMNQGDVCNSDLLELYEVHYHDLEWEVDDTDYIEPRCTKSQIIELEDYALIDESKTNYQPISFWERKSDGDICMNLETTLQICSTYRPHYHEFFVHFPARYIDKIKRVIFIGGGDAMLLHEVLKFPELEKVVGLELDQQVTRKSFNYFKSQPHWDEQRVEWWYGDATKSLPLLPQGYWGSFDLVLVDLSETVMSMSVTGELDIFSALALLLKPEGIMVKNEPYIDQFSNFFDHTIHIFYGTPKICTQVLVMGSNKVDFLDHPIKEHPEIERLLLEQLDDPADRFKYFHDYRKNNATEQGKCTLREGSVTTQQGKKAGILEILEVENASISSKQDLESAIYIVASDVGLVPVSSPSDTDGAIVAVMKEGYIIARIWAEQKYCALDIHLWGAFEKSSALRSALMEAVGSDTVSSYRIVVGGMFGSNTSESDNNAIGIQVSQQRNCEAEVLNDDENTGEDETMVIALLQTVDLLVAEKSNLKAVVLCGFKDEGKCWSVDVLAANDRAKTVLPIWACDTLKNSTEDPSVYPMMYECEKEVEDYLMRLTQGNNKIDMVILDQSAPRQMAQIFASIMSYTENPNNFTSEEHVFVSLIRDLDSELWRREFLEQYRRGKHDLPLFRTEISMKAADRNLGLHFVLCSKNGFGKIHELKAMLSKHASGYLVGIERVTGGSNYYDEAYNMVEFPDSAYDREAVREKGRNSVAYGRQSIFQFEKFSSNEGGMPPFDDLKSMFLASLTEMDYNTNWEQGYSDVGDGAVFVSKFEEGLAVLVWDGQKHVDVNLFSTDQSEERANGFRQSFITLSGLSQYLRDDQPRGTGGLMLFDFEIPHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL94</accession>
    <name>A0AAD2FL94_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000857">
        <property type="protein sequence ID" value="CAJ1939824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="123" mass="14114" checksum="E5DDE8E8A08E7545" modified="2024-05-29" version="1">MISRPKVVVLPITDQVIQCAEAWAAAKGVTSMKFFDRKRNLETFQDDDQITGVDDTEQGYLVEEAFDQDYEPEDEDERDFNLCGQFDDINDSKREELLADADNDVNDTLFWEVRGLSSVRVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLL7</accession>
    <name>A0AAD2FLL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001068">
        <property type="protein sequence ID" value="CAJ1941718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLL7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="697"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1198" mass="134269" checksum="D64AB1440EF65A24" modified="2024-05-29" version="1">MADADAQVAAMTAALTQVGAQFLAQLQAQQAAAAAPAPPARTAVYNLHDSGQPVDLSSRSGAAAADKASAKLPTEITGDETEVVIWIQDLKLHCSETYMDVAGPTGILHFGGKNLLTDYHSILMTDVVSQATLRTDPRARQNSSWLFKCIQSSLSPALLLQLFGLNGSMPTLGQGDGPTLFKAIMDTTASASLLVSMQALTDLGVLDPADFDFDIKKINAKASQLIALATTSARSLSDPECLQLLLTVYSRIKQPHAWFSWVQQKINDFEEGRLSAPPVAFEQECATHGVSIRHYHADNGLFDTKAFRNSITKAGQGLTFCGVNAHHQNGKAERKIKEVTEGARTALIHAAHRWPDAIHAALWPAALKNYTNLKNSLPTKYTPEIKVRGRIKQHAKYEESPISKMAQVEVEPNLDHFHPFGSPVYVLEDSLQAQHSHNKWADRSRVGIFLCHSPNHASSVPLVLNTRTGNVSPQFHCIYDDAFDTCKRDVHFTSSWQRKAQLHRDKTKEVIDLPSTDLFAKNQNQQEVPLPAVPQFITQWDDEHTIGELTNDFNTTEDPKTITSPPGENQESEHASIQEPEIRRTRSGRHSRPNPRIFNDQMATANSAYLETFSPALDHEELQGHELLQADHSEEPHPFASIFALAGSADPDTLTFDEAMKAHDRAEFIKAMYKELGDHIGRKHWKVVPIRSIPTYSGKRAIPMVWAMKRKKNPLGEIIKWKARLCAGGHRSIENVDYWDTYAPVVSWSTVRLMVIFALINNWHMESIDFVLAYPQAPIKTDIFMQPPRVPPKFVIPDMPRPGDRFTSVYKLLQNLYGLKDAGRTWGQFLHKGLIDRGWQQSSIDSCLYTKQDIILVLYFDDACLMSPNKALINKEIKSLQEQYNLTDDGELQDYLGTCFTKQPDGSILLEQPRMIQRILEMVGLTADQVKTHDSPASSANISDKDPDGKAHDYPWNYRSVVGSLSYLQAMIRPDLTMAVQQCARFCNDPKESHGTAVKRICRYLHSTQHQGLRFKPDPTKGLECYVDADWAGSWQDRTSTDPLSARSRTGYIITYAGCPIIWASKLQTLVALSTTEAEYIALSTSLREVIAVMNLVNELRSLGFNLSMDTPKVVCTVFEDNRSCLEIATNHRTRPRTKHLSVRLHHFRSHILAKTIIIKHVSTKEQMADIFTKPLPKDQFIRLRNRFMGWDSLGKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLM8</accession>
    <name>A0AAD2FLM8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001101">
        <property type="protein sequence ID" value="CAJ1941905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLM8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="273" mass="30531" checksum="E670FCDCAA184562" modified="2024-05-29" version="1">MIVSRSGKVVDVCGYDPSTTSRQLEVVTAAIAYNRPTTGETIILFLHQAIHFPNMDHHLLSTMQSRTNNVTINDRPKFLTACPNDNDHCILAPSDDLNDITRLPLPVRIHGTISYLNVRKPTAAEYATCEHVSLTANAPDWDPRTTKYQLVEDSLVDNAGRLLERGDLKNRHFISPLYSELSTNNPRIISETVSQEHAILHEIDPRLNDHHFSQQLSDMVQISSVWSAYKGPAVDAIKLARNWGIGIEAATKTIQATTQRGARTILHPSLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN55</accession>
    <name>A0AAD2FN55_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS10893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001717">
        <property type="protein sequence ID" value="CAJ1946904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN55"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050343">
        <property type="entry name" value="RsuA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47683">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47683:SF3">
        <property type="entry name" value="RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="32"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1946904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="241" mass="27615" checksum="43FB8BEF956C3EB7" modified="2024-05-29" version="1">MDDWKEITKGGVTVKVKGKPVIIKRKETVPRVWAVNKVSGELVGEKDPQNRPSMLERLKRGGVGRRHDDHLKTVGRLDIPTEGLILVTNDGNFARDLELPSNKIHRVYRARIFGSLRRNQLMRIRNGFSGFQPMKVEVERRHKATRESSNTWIKITATEGQNRQIRKVFQSLGMSVTRLIRISYGDYQLHSIPPGLAIPVPWKPVANQKRKGSLFKKKIKHHEAKNQETASVKWTRGFQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNG7</accession>
    <name>A0AAD2FNG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042217075" description="Mitochondrial pyruvate carrier" evidence="1">
        <location>
            <begin position="29"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22298" checksum="9D09D8D6AD46CC39" modified="2024-05-29" version="1">MMMGISFIQVTVVAFVFFLSIATRGVDSSFIIEPSSYHTSRQQSSSTWQLMPRINYPKVGSSMEENVSISARSSISLCAAKGTNDNKPAKKKPMVGYNDDAFGLIFLTGGILSQDADFVVTFVALSAIAAIASNASQEINDTRLPGLVAMATLPLTPVVTYLHAAIMMADDGQGGSIVWTAPQPIEIGLCFVSLAWSYAKWTQEQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP12</accession>
    <name>A0AAD2FP12_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP12"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042174014" evidence="3">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1947883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="254" mass="27633" checksum="01459F53AA8BD8F4" modified="2024-05-29" version="1">MNRSTMKLLAIACFLSAATHAFVTPQRSHTAVVPTSLFAKKKKSSGGKGFGTKEPSSTPPKSGPVEPMMMEREDPNAATTTFTSVEGGSNAIPTLEEDPKYANMSPEERASAILRDQYGMRTRAEQQEEARRVEAAKEQRKKLEDWKKMADEGKDFDIMQVLPAPVLIFIDRFLKVGVAICTVLFVLAGVGITFEAWSKASNSPLPPDIDRFIVDVIEPNFTPGLGVLLGFSISLGAFAAAQLSSASATYRQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPF1</accession>
    <name>A0AAD2FPF1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS11493</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001744">
        <property type="protein sequence ID" value="CAJ1948175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="10">
        <location>
            <begin position="49"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1948175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="18518" checksum="0387D52434DAD75C" modified="2024-05-29" version="1">MVMDKPKPGECTKEEEAEQVKAQWEPKDDKTLDKLKQAIVTGPILKRPNPKRRFYLKTDWSSNAMGAVLLQADTTEEAEESMRKEIEGGKCEFNKSMSKLRLRPIAFISRICKGKECDYHSFVGEAATGRWAMKKFQQWLIGKEFTWITDCSGLTKFFQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPF9</accession>
    <name>A0AAD2FPF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1948009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="34"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1948009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="367" mass="39379" checksum="0DB3B87A604197A3" modified="2024-05-29" version="1">MSEGVSSKTDTVTNTKWILKRRPQGAFDPEKDAGMVSEEMHMATSCGDDEIVIEVDTLSVDAFIRTMLDEEAYHGAIDLGKTIPALGYGKVVYSGKNANKKVGSTVQCMMGAQRFATVKASDAFPKMDLPRMSSTASLGLLGVTTGFTAYAGIFYVCKPPKKGDTVVITAAAGAVGSVAVQLAKSTGARVIGIAGGPRKNQYLIDDLQLDGSVDYKDSTKTVAQQLEETCPNGIDFIYDNVGGQILDDMLLKINPNARVVICGAVSQYNSGKLNKGLVQGPSNYLKLAERGATMKGFNVMQYLHKLPFMLFGMFWLNLRGKVTMNEHIETGIESFPKALNHLFTGASIGKCLVAVKSGNTTADKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPG6</accession>
    <name>A0AAD2FPG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS11537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF121">
        <property type="entry name" value="OS09G0315000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041959063" evidence="8">
        <location>
            <begin position="28"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1948279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="242" mass="26978" checksum="DC880B09ECE14E39" modified="2024-05-29" version="1">MKFFLCRIALLCSLLALPVQSFGGVDAFFRTSPYAAAAMVCGMKGVCADFVAQKHQFKKNRENGDDMVVKMNRDGSLVTKLVQKIDLKRSAAFLIYGALYQGLVLEYSYNHIYPRLFGPGQDVLSVLRKVSFDMFFQSPCLTLPSAYISKAFVFGNPIGGAVRKYVDDVIKQKLLLKYYVVWVPVMFFAFGVVPDRFRVTFCASVSFFWMMLLSAIANNSGEESSSSSSSSLSKNSIKAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ06</accession>
    <name>A0AAD2FQ06_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11901</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12592</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20398</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001768">
        <property type="protein sequence ID" value="CAJ1950453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1963952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1963952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="183" mass="20645" checksum="B44F44A0A17EB6F2" modified="2024-05-29" version="1">MATRRGKRNAKETPPRSHHKKKRVYLCTHASGKQWCTACDSCKRCKAPPRPDLPNDKQCQAHTVATSTRIRKKSINGLEYCMPTVTPHKSGRPKRTTYDDTVGKIQQTTAEDAQVEADEKLQAELAAIKSEMKVENAKTVQCIREESEAEALKLLIQTNGKDVELPAEFFIESLKLRAEILRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRS8</accession>
    <name>A0AAD2FRS8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="530" mass="59457" checksum="B6A49C5A6AD00BD0" modified="2024-05-29" version="1">MATLLRYATRLPGAKGHCRPLMLPESCLASTSTLTSTLGSRQHPFSSWDYELPWSSAKSDKSSKRLVQRVQESRREHQQKVDLQDALMILVEGYLQTNHKEAFSIQSASQFWKKETEAIDSSKKKGNDSKDSAQQGRLQKNRKTIAIHDALIELTKLNGFKPVDLPREQVPLAEGVVVRPQYHKEEKYRDRVRIKASPLMWARSELKTGQSPLTFSSSVMSSAQPRRDDLPELVEEDIKLYRIIEKSVDDFVNAKVQALQTSVRALETKIQDAVSSVVPSLRRQDAASKKSKKDELDDASNVESPESLLFLDRNEIIWVTNMDNRELRLLALQDHHSYGLKLSSWLISISLVVFGAMPLAYRSYNFTYDYPGLSQSVAASVVLTISYGIWSTQSMAVTRQSQVVSNAVAHRIYARNNAVLWALQQGAVERVSDALLTYYFYCQNDTRQRLRLRPSSTSKPLLAVTQPSGGKQESDDPMLPSTSIDVVALAKEIGLVQEEATSSSGNSKRVAVPIESAIAAAQDYHKKIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSF7</accession>
    <name>A0AAD2FSF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSF7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="212"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="315" mass="36240" checksum="E258827ED36AC90F" modified="2024-05-29" version="1">MADIQQSFIDDSGSRHCHGDSMLQEYLLALLRQPLPSLEFPVPSFEDPFGDPKMEPLPFQKEVSSSDQSETDFEQTVTFKDEPIVDVGSKNGVSQQDDVSSPRQDQHDDDSLTSSCENQGSRRTDEAEKIARFRPYQDKKWKGTFQRLIKFKNEFGHCCVPHSYAENPALARWVKRQRHQYKKFMENDPTSTLTTSRLEKLESVGFVWHSHAAAWLEKLDELKNFKQARGHCNVPSSYPENPALSTWVKCQRRQYKLRVSGLQSTMTMDRFGVLKSMCFVFEPRLTTSKNTKLEMKARAEVKSFDASRELLGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSX3</accession>
    <name>A0AAD2FSX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS13495</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="154"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="154"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1337"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1384"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1469"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1594"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2234"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1337"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1414"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1472"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1594"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1952324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2461" mass="271929" checksum="DE4F3D05E0D8A266" modified="2024-05-29" version="1">MDPNFNPAPQLPAGFASNSNDASCAMIDGESNQPAMGNSQESKSAYTRTMQLLEHKSSFLSPVAAVVNLRDVVGNPPLDEQEGMGTTLLTPNRGHHALFRALEELEGMEKQEAELLLQSPLTNALTTIVTNDSYPTPRQAVATLEALCKAIPRRVCQHPFKKNDIVWVCRTCQADETCVLCHNCFIQSDHEGHDVAFYHAQAGGCCDCGDPDAWDPRGFCPHHGPKSGQNHGISEALMQRVLGVVPAAVDWMVQQVAQTAKEGYSRAHEQDDDDDDDGKDGEALDTDADTSIVMGDVMFLPTAGIATTTPMDETTPFPHNGGAMPFSPNKAGATKADRTEPKALFAAAPEPLSVTAQTPAPPLTKAEKLGILARQGGGMFLVLKSDDIHSTLNWVDALRELFGTSSLYTDSILHKLVKALRQFGQLVVWGTMEILAEFNTNQVQMWLDGDRVVSGLVGSTMLRKAKILVDHGLFCSILTLDELKAEQRAVGVLQWLMCLARSCDPLCQQVAEAIAPDRHLVPLLIADFKLSSRITKYWHSLLLTLLAVPTFKSHLAAAYCDTYQSVTAEYARGMGVLERSGYALSVQFLNRVTYVVDLVQRRDLLGKLGASLLETLKLATKPPPKLNPNHFVMTHRRYSPCISDLKCVLNVKGMPRLFASKIGSFLRDWIETLSIGQMMDEQVWRDYNQGHVELEVRGWVGAFNGSISLGSLFERLLSWKDDDPSPIDDAESPLCKNLLSCVDLTYHVLEYGIGKWQTVEMYAYKPTRSTVESHDRKPASLPFSTLSEKNGSALAFRALPMSQKTPFSFHLPLQRFVAACLREICLREDAMDDLMLKLSRDMFVNNKDNLFLGLMEFPLLVLSRSAQVRAGLWRRNGNGLNDQVLNYAEPPFCRAMRDADLLLVQFAMLGRARHQSAETRPDSDIGVCFMVHLLLHRLGIFQFCGLRNGAESNVNRYLEEVGKGLYDSEVKEESEGDKPVLPWTYASSRDVSSQLLLLEEFLHAMIVFCVELPAEPPSTKREHTEQAKERLRREVIHRLASGPKMHSELAEVHHVLSHWDNFYLGEEGKQVNPDDATGAALGAVLADVATRKSAKGKMEPDKWVLKKNVWHCYDPSFFHISLRSHQTAAESRPTPNGQNPNYGISPKAFCPIPAPAHKSFVRLRRDISCDAITISTAYRTLHLHCRKPDKEKEELGLSGSMGYESDERSETALTRAVHLLTLGAFAWKDAKENDPAWRKRGGGSVGSLFANWADNDAAPTAKNWVSAVMLTSPKALTDNEWYEGEDNCLVLLRRLAVDGGFAGNFVAQDRAVRAGAAWLCEFAAQHNDDARKFVRASQSAVNSSSEVETGETDIQRRRRMAKEKAMERMKAQAAKFVSMMDTEFGNEDETETPKSAELSIARSENSDSAGMFESGQSSVSSATSANEDSSHHPLTPDAQQRSPEKAAAISPRLLSVRPRCIICSDDSGVEMQTRDQTEDRHRKSRKRRSDGGNALAFVGYSQASTVMKGGGPASTSEYHVEAPVRRFVGAHVALCGHAIHSECLESYLATVSNREDRTFGKRDEFRCPLCQRLSNSLVPFIDVGADWITCKPCTSESTSANSSNMKSDDQSQEDMASTKPATLNEFLNSTPWWVSRRNKNTLWDGQCAFVNRPTETEEATTESAAVVPPKLSRRKSVRPLRKKDLYAAWNAMMKTPRFVRRKLKSRGGESNALESHLGNDLATSQLFSSSESAGETVVWRRFMDQVSDITYRADGKRLGDESLHNDFGEFRHYIVEKYSYNMAKRFAGKEASDWPSCVFPSALSDIQRQELSREKLLSKLMMSIQAFTYSCCCEASEARRLVRKTTRLSGNTAGASADDNGLAPVLSKFGIDGIICDGKLVMMPKPSPSADDGAQPFTGRLGRLRYLGLAVMAATGPLAADLIQLALALPLTSSDGENAVTTAPDSPFRAPVVYPLLFGNVLTHVVVAICATNGRDRARSDSLDLIWPVPFSRDGSFLSPDNATDASESYSVMSDAEGFVKLGLLARMLQVLLGKLDMQGLDNIPGLETEFLVVKSLSKLRNSEFANFTSVEGRWKLCCITMLEMALSKHSNHEVVPEQPHVEKAIFDRLNEGCFLAAAAACSYLADVGVIMQILIPDIMSRYDSQDMSMTSDSSESDSALETFEKLRNSFQMEPVHEMLEATTIGEVLSNWYETARHHEKRAMIASDSKSGFGGKSSICSRLNRTQGFRVFDWPMEPSGHHKKSKTPLNQGENNSKKRGAHPLEPEDDGTAPMDLDEIEPMSVFASSSELQRRVALPLVTFSSKKSVALLGGYRAGFPAKANGRPRIAMIPTSYTDLYAELGRLLPDSEQTAVCLICGEVLNAGGKGECTKHSFKCGAGTGLFFLLQECAGLIMHNSKAAYIHSPYVDSHGETPQYRGRPLNLDMERYDHLREVWSGHAVRQQVLAERASSRQIIVQDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTK9</accession>
    <name>A0AAD2FTK9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001817">
        <property type="protein sequence ID" value="CAJ1953096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTK9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF470">
        <property type="entry name" value="CYSTEINE-RICH RLK (RECEPTOR-LIKE PROTEIN KINASE) 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29728" checksum="D983D47506054D83" modified="2024-05-29" version="1">MPQFWRSDAHQRLITIKEPTTYLGATISKHKLDGNDYFTWAIGSEAYLQEPLRVVKKRIAPMQLTLKKKVYSTLPTGYKPELDSTPFVDDDTAIFYMQLIGILRWLVELGRINVAAEVSMLLSYNAMPREGHFHAALHIFAYLQKHPDCVLVMDCGYADHLRPLKKADYSQFYEFTTKNELPSEMPIPLGKAVEFTMFVDASHAANVVTRQSRTGVLIFVNKAPIIWYSKKQNSVKTSSFGSEFAALKTGVELLEGLRLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUV7</accession>
    <name>A0AAD2FUV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS14341</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUV7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0278509-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1953738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="473" mass="52708" checksum="1B382FA9AD9940D2" modified="2024-05-29" version="1">MAQEKHDLQLEDVQDYTSDYPPDYPGAEGAETKRRGLLCGLIMGNKKMTCLLALVFILVIAIVTILVVGADENAIEGFHQPLIIIDPSTLDASVTGPLMASLLAMYDRNGMDSTPLDPSSGDDTPQRRAFFWLAHENQNLDHSTKMARYALAVFYYSTNQVPTEFDEEPETWYVARRWLTKASYCEWHGIVCDAQGRVEALEMDRNFLTGVLPIELRILEDTLYSIDIADNGISMSEENFDVFLNLVNLEEFFGDNNYLEYSEGLPPQMASLVNLEQLTMSYNLLGGDLSVDNVIPAMGQLTHIEMEANYFSGPIPDYIGAMEDLVYFYMRRNNFNGDLSFLESGAMTTLFAMWLDGNDLTGNIPAQIGSLQNLASLSISNTKLSGPIPAEMGDLLKLRRVWLYDNQLTGDIPLALQKLDKLEVLELHNNNMSGSMPQGICDIFSGVDYDFKALTTDCNGAVACSRSCCTKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV39</accession>
    <name>A0AAD2FV39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="65"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="277" mass="29836" checksum="980640E756B7EA8C" modified="2024-05-29" version="1">MSQNFFAALDDSGDEAPAPAKSVAKKREPKTSSKSESSSAVTSRRSNNDRNTKHGRGGRNAPRDGKRAYERRSGTGRGKEIKKGGGGARNWGSDKADAKKMEGTINEDEVKEDAPSELPVEEVVEAGIEEAPIEEKPEDNTMTFADYMAAKEKKEETAGRETEDEFKGFNAATKVEEDFLVMGGAKQKKNKKKKDGEKKTVEVGFRVANPNSGRGDRDRDRGGRGGRGGRGRGGRDGRGGRDGRGRDGRGRGRSSGRGGRGRNSGLNVQDETAFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVC4</accession>
    <name>A0AAD2FVC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001848">
        <property type="protein sequence ID" value="CAJ1954024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="26358" checksum="4D0B25220E1F8032" modified="2024-05-29" version="1">MGRSSSGGGRGRVTPQKVKSNSSSTVVKHLFSTKDENDGKARSSYEDAEERVIDYIQASGMKCSKDMVKSIRDGKSIDFNAIAPRLNAPTQTEAVARETEMAQNKILYSAKLDENMRRSAYFKTNKRTVKSSIMLKFVTKAMDIKLRGEADFTTTLEDPIELLKRIKQFMKKSADAEYDFLHFWEANQKFFAMKQGTTENLMHFKERFLRQAEVLQDPTFCSQDESVCCYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVG9</accession>
    <name>A0AAD2FVG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="929" mass="106280" checksum="626053407C5B1BDF" modified="2024-05-29" version="1">MNAERRPPPLKHIPPSSPPPKERVLHSIFSPSYHTDKQGDKEEVQIGFHSPPRRSYATSTEEGPAIVGATLSTQPNNLSPMSAISAFTAGTSHWQQEKNRRRTITSTSDDALNTSVDTLKTIEMLNFKFIRSCDSPDRLERVLKVLNSTKRDSPLLLQETKDRLSTLRQTQNQQNGAYKSTRLLHQTEMRTEFESPGKEYFSSCAANISRITNGNSTLDSIDPTKTNSLNLSLSPQSVLHGVEFVDTPYGDESTSFFQPSAITETPNRNEIIAVEKRLTPIEERTGSSPVPPPPPPPPPSRPIDSHKTKEKVHGSFLQKLQNLETAKKEAEKVVENLQSQVHEANNKTKHMQTVVREMTKEKKKQHEEAEKERKTFEAQQRQATTVEKGLQERVSSLIEQLRQTEEKARLVMRAEKNIRVEREKQLSHVQHKNQELNAMLEKAKQNLESMKQRQATFRMELFRCMGLSIDEWRNSSSRDLLAELSKKMSMMSEENRNAKIEIQSRLKIAEERERLEAQLQKTIDEKKQLQEENSKLSDRIQDLAEEVESSRAYIDKLLRTSHDANQDDWETREKKYKTVIQNLRQQIRKQGSTVKLDLYKSALDDGKRKSQDLQEANKRIATLVAKVVELEKTDKTSSALGHLPSPEGKQAVRRVAESPTEYLNGETNTRSLGKPIRHIMGIEQTNDEIDMRPIPFKIDQSYEKMETKTPIQRRKSQTKTPKSHDKSVSVITQHKSPDYQNAWTKRRNKDDLLGFEVLIPAETIETSEQRTSRFKEADFNVWNDNYVESPQLNSKTSNYPSRNKFVQKHLNSGKKKNKSPLLERKERRQRQEEAKRRELLSQSKEDHTGTTLTPVSKKSTPPHLVGDENVDPAKSDCNSADFAPVSSPRKSTPRELARQAGGRRALAEKVRKMRSPSSKVRTATVQRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVV5</accession>
    <name>A0AAD2FVV5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVV5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35372" checksum="8C3B07E3EA0F2388" modified="2024-05-29" version="1">MNANIPLEEVFPFSPRVARKVLICDSIETDGRFVCYTYAKQAVNATCPVLWLLGTPVTEMQVATGLKKMGCDAGASYLRDESLTSAGGGNKTLTIRSLASELATATLDLKDDEEEEWSEEAFLKQLYQQAKEWLLEKLELASTTDSPCWIILDDMSTLATMLSESLVYQFIDTLIALVSRLGKMDQVGILIRVSNQLDQTLLNQSEEDFIKDQSGWVGAGGLALRLARRQDQQDWIPWERSLLESMDGVVDVLPLASGYSREAHGRLIFSELPSGRGWSESSTNTTVATTSSATTAWNKLVFNYCIHDNGVKAIRLRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXP1</accession>
    <name>A0AAD2FXP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="142"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1956085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="315" mass="36923" checksum="3F6AE7FAD8776343" modified="2024-05-29" version="1">MDEPPINHLVTPSEMMESGLALKGYSERRIKRAKGKTNVFRFKHHFGVSPCTAVWVYTDMQITNIAGAKIKGGILDLKYFLIGLYYLRKYPTEEELTSQFDYSNYWVREKAWGTIEKIQLLKHQVIVWEDDYQQGKRWVMTVDGIHCWINEPSHKEWSQDPKYYSHKYNKAGLDYELGISLVDNRLLWMRGPFPAGTNDITIFREKGLLDELKKRKQSAIGDRGYNGEPKHMSTYNAHDNAGVRLFKSRALKRHENFNSLLKQNKILDTRFRHNEDRFASAFEACCVLAQYRITREMSLYDILIEDVVDTYEGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ89</accession>
    <name>A0AAD2FZ89_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ89"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052828">
        <property type="entry name" value="NELF-A_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13328:SF4">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13328">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR A NELF-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="650" mass="72768" checksum="6F44695967688E44" modified="2024-05-29" version="1">MPGGESTRRSRRTNLGQPPRRLGEEEETLEQDSNRTVRFRDENLEEIIDNRTAQVEMDQGQGAAPQQGADANAANQGNNQNVANNPAQAAGNNAGQAVTPQLRQVIATEIANAIGPLMQLLQGQQQQPPQQAQPQAQQQPPAPHQQQQPPAQQIQGQQQQPPQQAQPLAQQQPLAQQQPAQQQLPPLQNPPVPQPQPAAAAAVQQPQIVMASMSTFPQGTDPMIDPKDPVHGRLNRSMYNEAKEELKTKIDGKNLSMVISELRERCSAINCMDLFNVVTTNGTKNLLKHYGEITFQDTRQEASQRWMVANWHTQARYLIGMCLLRSMTEMFKLRMTQKRHLYNMPNDQPDGPLIFKVMCDVVRPSTRNTTQTLINRIQTMKPREFNNNIIQFNEKFTSLKEQIRAQQGGSNSLTEELLYNALVLAYDSVDQDQFKAFMGVKDNSAIQPHEDLMSEADAKFLDLDEKKVWNVPSQSQQIMSLTTLISKAEKKTIDVQRQLDKSKQSRKEKSKRKPSPADEAADSGKRQRQTDFDRWMVTKPKKGEETKVVQKKGPNGQVKGWNWCDKHKKMVLAIGRDGRPHNSDTCALSKTQSNSNPKRAKKQLRVNALKAALALEDDSASDNATSNSDDTGEFPTNDDGSNENDSDNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZT1</accession>
    <name>A0AAD2FZT1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZT1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="307" mass="36383" checksum="72A9427426E647F0" modified="2024-05-29" version="1">MGVVCWSAYKLTIFIQVVDDDQRGGRRPAITSDPTAFNQSEWKVKSGSTAAIDPKDQPICFVSCGYSDTAAQLDPLSDVHDRYPDFKFFIFTNLKDQEWETPGWEKIITDFTFRRRITHSRYGKFLAWKYDKIRNHCRVVYFMDPVLEPRANETTFVELAEMIEAYEPGFMQFRHPRKRKSLMQEFEGIAMAKKDYAANIEKSINWMKAQPDFNDTTNIFLNQCIGYNPRSKIFQEITTSMWSRYSLELDSWRDQPLWAFMLRRHKVAPKVFPISWWKLFKKKPPNEHGHNNHEYQSEEDVRSHNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G023</accession>
    <name>A0AAD2G023_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxin-12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS17325</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G023"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16451">
        <property type="entry name" value="mRING_PEX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Pex N-terminal" evidence="16">
        <location>
            <begin position="130"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1958736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="457" mass="51355" checksum="1553D22E57BCAA93" modified="2024-05-29" version="1">MIAHPTTTVNDVNPMVPTTMGALLAEEWTIDPQSILPSFFEMMMIAEARRSGHEALKSGFSFVESKLDEFVNNDDSPVAGAASNSDLSPTTTENDNNNTDENQTSPRRSRWFEFKKKAARILLYKILKPWNPEIRCLIIYLVQRGSLLSSDAAASETIYGGKRVKLETRATGASLGYSEKRRLTPMSRKDGIRLAFLLSFSTYFEERVDGYFQSPTSSVDDSDTIVSSSSSSSSSSPSRIQKLKKMIKFLHPFMHISIQGVHLVEQWRFLLGRSVFFDPYSKFLNLVVRRVTEQDQIQDEKNNSSKKKQQNKLLESTLDTSKAILNNALFKKTVVGVLTTALAIGWMARVRKIRQRLRRQVLPNQQQQQQQQQSENNDFIPPPPAPLAAKNPDLLSLPATVCPLCRQTRINPTATTAGYVFCLLCITSHVRENPKCPITGRDCPESALVRLYEPNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0A5</accession>
    <name>A0AAD2G0A5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0A5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="367" mass="41989" checksum="27EA01D7541BBC38" modified="2024-05-29" version="1">MATFATAFPTTAPTTPNASSSLKRRMSPISHNHSPNWPEYDAPTAVLVPPSMMMQQSQYQQQSQYQHQQQSQQPSFKRVRLTHNSPGEFCLQRDLKSLSHSHQWNHQPSNAIGGGSACGWVYEQDPNIRLYKSSSNNNDNNINNNWGGQQQQQQQLQLQLLLEFSQDAKITISIPRMYPHEAPTVTNIQGLWMDSILIRSLQPNQHCNHHPDYNQNGGDAVAQNNTNNNKTIVFHWSPIVNISTLLEFCISHAKMHPTYPQAKLPPHYCLGERSTNTLHQCHPQQQQQQQQQQLQHSHSAKGTMHQHPPNNINDSENNEMEVSHPFKYTSPFAPNRFDVGYNKQQQQQQQQMSCCHSNNGQDTMMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0S0</accession>
    <name>A0AAD2G0S0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0S0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="650" mass="72104" checksum="49B387053487DA3D" modified="2024-05-29" version="1">MTETTQKKKKTRKKSTDKIVKSKAAIGIEDGTGRKKKKKSSTNKAAASKSLDASSTKKTKQKRGRSTTKKNLKKGALKNKNFQESLASSVDTAKSTNKSNRSQNSFNQLRPSSLSDLRAPSQDTAASGRGRTPGRGVIAKRPRSATGLDHSGHLSIRRLEQAERGKSSSSLFRQSSNPNLSRQYSNPNLSRQNSGLSLGGGSRPRSLVQRARSTSTVEPPSSFTGRRMNRLGARGLKKSGSTSGLSRQSSRSSLYASSDDDGGSRSRSRSRTKLGGGDPDDLEKIIGMIESSNNPEILARQKPRSRYERFAQRNRLSSRSLDASVSGHTASTVGDEFSADETIWISGLRYIRLMAPTPRECKSDRIIRYMTWGAMILDFIAAMVSITTYESVTMCCGKPIFELLESRINWNEFVRIFTYIYVVLLFLEVIPVFNKEIPLNLINPLIGFTITMAMFFDDRIGEAITMWTMEAFAIAFEAVITCLRRKQHLRRIERIVECDDELAVRTGKRWARDNSTKQLNPADGIVEDPYSDLESLSGGSFYNSGDAKVNRFRIERERRHLKAGLLDDEITLRYHYIGSAINIGLVLISLSLIIGIGKNGGLCISNFEAPPIFKDDQLERCPSCVGAAETCEVCDATGGNQHQCYYPYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3B9</accession>
    <name>A0AAD2G3B9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3B9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1961229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="88476" checksum="631632A323612EF2" modified="2024-05-29" version="1">MMEHRQRPANNNKQGPKGGRVLRMNGARLLAIISFVAGIFMTSIVFFARTIILSNDDSLNEDHFRSMKNIKSKDDCNCQESDHYKEQQEQMAVQKQLLEDLKEEINRLSNQLTGSHQPVKEEVVVAAAAAAKEAAVRHLDASSSNLVQYKTELAGMLMNMWDLAEDKQMINDHSGETSVQRLMLNTFMHEVSDQLPGTLAGMRCMIFEFKYISQFGGCRETFHFRHDPNEKGIINPMTTKYGTYGIIKGDLEGDVSHVPQEYFDMAIYTQQMQHEKHFWKALPNLAGTIDEGGLLIFSIPWAFMFHPLRGDFYRYSPSAVYHLLESSGFAICHIVSDGWKSMQMHALGLGVEDIYDLESVLKSQSKVSLLSGATSYMAVAQRVEEIGDPCTLQRLKLSNEITREEINGFGIHGEFLPDPMKDFPYGPKKKKTMKVPNKRAKKDAKKKSFKIVINDPPASEDEDEDGSISSYDDGVPEEQFQYQYQYAIPVKTPPPTRGNFSVEFTEVVSDYSGPIPPKTTCFVTASYAKTLQSMDNMIHVRNTSPYFKFFMFTNWNDDQWKTPGWIKITTKYNYTRSITHSRYGKFLGWKYDQIRQECDAVYYMDSNIQLKANQSTWMEMSATISSTEPGIMQFKHEQNRSGIFDEFAAITKWKKDYAGNVQKSIAWFSAQPDFENDIPIYMNQLFGYNPKSPTYQRLSQGFWDHYSKEEDSWRDQPLWAFMLHRYNVTPLAFPETNFKRIWKVPNRVNFGHHDHRYTSEADVIVDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G525</accession>
    <name>A0AAD2G525_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002106">
        <property type="protein sequence ID" value="CAJ1962487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G525"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="190" mass="21615" checksum="6118F55CA71C986B" modified="2024-05-29" version="1">MGDDSGFQGVSPFDFAMRQKNEEKKRKEREREAKAQLYKVNMAAAGFGVEQASRTADFEREKARQETQRNTIKSNQNIVVTETVATNELKALALRGKAEKETERQTIMDNQKVVVSETVETNELKALAARGKAEKETERQTKANLKDVTITDSVEGQVRKEQHKMEKDWKEAGKQQKADNTNFDMARALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5A1</accession>
    <name>A0AAD2G5A1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5A1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="507" mass="56661" checksum="39CADF7020EDDCF7" modified="2024-05-29" version="1">MAAFHGCISLLEIAIPPSVTMIEDYACQDCWSLTQVHFAEDGLLTVIGMKAFFGCESLSEVNIPSSVETIGESAFTGCQSLARVVLQEGLKTIDSGAFMECVKLEQVDIPRTLEVLGSSAFYRCTSLQEVNIEEGSLREIGGQAFQGCLKLQTVRIPSTVERLESETFTSCESLRVMQFQSGLKYVGHEAFYLCKNLQSVALPESVDFISDSAFYECFKLVSVELDDRPRMVMIFDHAFEGCESLINICLEPSPSVPASTRIRNTSFQNCTSLQDQYGAETGILHGLLRRFDGFPIHKKCYHASGTTADELAQEIESSVRHHLVLDPFDMTPFHVLLSAANCRLDLLQILLDAYPPHVLGWKDVNGKTPIEYVIRRSSNRLSNDSRNMLRLALQGWLVGSISSWNGLEAWKVDMSICVYAILAEDEVEERQSLLQEASMVLSRYERMEATTRLELSLWKMELKSVDDQVSAKNAARTIVDKEVYRIRSGASVVIPNVITFLYETNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G685</accession>
    <name>A0AAD2G685_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G685"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049226">
        <property type="entry name" value="DUF6823"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20709">
        <property type="entry name" value="DUF6823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042056804" description="Clathrin light chain" evidence="1">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22129" checksum="BEFAC846A9B3798D" modified="2024-05-29" version="1">MISIQLFALLATLMVSIGGHVHAFVAVVTTTTLGDRDSSGVTTTTTVRKMGMIDDLSLIFSDKGKKNRKAYEDRQRQEQEEAQRAILEARRNPNKKKEYLQKVDERRNKLDAERDVWSFQKDSSGADPLQTWRELRSSGKIKAGDDIARDPTSSRLGSAGLQDIRTDDKLPYIDQGYVDESADVFANLKNMFGGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6B7</accession>
    <name>A0AAD2G6B7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6B7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43574">
        <property type="entry name" value="EPIMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="55"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1964257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="395" mass="44058" checksum="5E852975D352C32A" modified="2024-05-29" version="1">MNKSLDDSQHTFPTTTGEGSESDASSISESSSASTTASWSDTELMEPHVGYKKVLVTGGAGFIGSHVADYLLERGDDVVIIDELNEYYDVTIKESNLRLLTEKYGEERVAIYRGDICDATLMTELFEKERPQWVCHMAARAGVRPSIEDPFVYIHSNIQGTTQLMELAHRYGVQNFVFASSSSVYGGSKSTFFSEDEVVDNPVSPYAASKKTCELLAYTYHHLYKLNVTGLRFFTVYGPRGRPDMAPFKFIDRVSRGAEIQQFGDGSSSRDYTYISDIVDGVVRSIDRPYAYQIFNLGKGDGTSLREFISLVEKHTGKAANRKILPDQPGDVPYTCADVRKAQHLLGYTSKVSFEDGIAKTARWYRQTYMKNKVEVLPQVEAPTTTIQLEATQAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G744</accession>
    <name>A0AAD2G744_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1962078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G744"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="788" mass="87956" checksum="7E4CBC72A0F69012" modified="2024-05-29" version="1">MEVLVADGAEDADGLEMHPSSSSSSGLSKKLTPRARFILAAFGLFLVCVVTSLWNSETTGDEVLANMYTKPPDAILDVENNKYDVVVDERVESNATEETGFHEGVLNSSNIISINEESDVEELISPPLPDTPVTSDTGECSALCDSRDEARKQKFGGDLLDFSDVLRLAEKGRANLHDKLKEDYGQYFESIFIKEPGPNATKDSPPTYQGMTPITENGPSRNNFKRKLKIKVLKMMESIKISDENVHGCNCLTKTGSTAENEESFAADIPDYYQKYVFANGGHSSSAGHGNTFSQTYTAYMGEDLRFVWDAIAVEMVDRNMGMGAMSACPHISSCSKEIFGDDVDFLAYNYAMTDRFPSSWLHYVYRASVSSGRPAFVAIEYMGHIMYGPVLEDNGLSIFQLRSHDAPLIQNIPDSSPDGIELNAAQTNQLPEFAKHLKCNGRIEGKDVCFHDKWKCTMGKLPCDCPSVAKRSSWHPGYKEHALTGHFLALPVVEMLIESISDLMTMDKDPMTVLQDLQKEEDLAYKNFFTIPVQDTLTPGIDRKGKLIGTLTERFIEPLGEEMEYFFKGPSICRTALLPSMTRYLGIATNSDKVGGSARCGEETYDLGIPFDRNNGVYTYTSNRTVPPGEWAIMSPNDMRSCNDDCSDVVMPDYKDWYMGNWSSGSASITFPNKKEKEYYAYSPEKFKGILALMTTFYQETTGRKQNKRKYDIAGENFQENVLMTVNGEPVKKYRSVDGLLILEGPDGIYWKPSKNNDYVMEFKPKGKIDGKDAIEMHLRLSGFLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7S4</accession>
    <name>A0AAD2G7S4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS21441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002229">
        <property type="protein sequence ID" value="CAJ1965851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7S4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031852">
        <property type="entry name" value="Vik1/Cik1_MT-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16796">
        <property type="entry name" value="Microtub_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="506"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="330"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="588"/>
            <end position="595"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1965851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="641" mass="73107" checksum="696CF5286B48564C" modified="2024-05-29" version="1">MSPFHDKTTTAHGVFRDGSSRYNTLQTGRETPHKRVKSGADGNNENPAALSSQLLIGRTTPQSLIRTYSEPNGWNGGDTIREPSPARDRRAMLEDWRRRKGRHVTGTDSTSRKRVKRMPSSCRAGYHNRNDLQDTHSSTLQNKSHDDRDEENPIRKYLVSCATPGQGKLGSARRSSLMEKSVLSSTPEVHKKGTHPSSSNSAQVDTIDDAGFQSQMERMKRRLEQLEKEKMDLSMSKAPLEARIRQKEDAWMKERARLMQEVQCSRLSLRQADDKYCDLQVQYDQAHDERIQLRQELRKVSSSRQNSKDIGLWSRKIQNDQDLWDLKEKLRASDEELKSTRLAKTSLEKELHATKIELDCLERNNNKMQAEYDEIAAQTSDNRDAEIKLQVLTEEHMATSAALNAVYAELDATKARAEATISEKDETLRKEIEQLRFDLSVMKTRANKVQLDLNKSIQNAEDEDEAVLRARIEERDQRIIELEAELLKGEKVRRHMHNCIQELRGNIRVFVRTRPFLPGDEQDKNSPINITPDGESMSIIDRRSGKPLIFHFDKVFLPSAGQETVFQEVSDFVQSALDGYNVCLFSYGQTGSGKTHTMQGCGNGPMRGIIPRAVEQLKGFACLHALCTKFHAWAKAFNQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8B9</accession>
    <name>A0AAD2G8B9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UvrD-like helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS21750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8B9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="610"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="631"/>
            <end position="638"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1246" mass="141303" checksum="748AB11C022FEB65" modified="2024-05-29" version="1">MPPQDDSASDSSEDFGPPPLVSRDRNGDDDDSSDSESSGDESAPALLAGRGRENEDSSDDDDDFSGIPALIHGAANALHGSDDDDDHDDDASGNSMPPLQGRNDKSNNSNMGNDLDNDSSDDDADVPALTGGAGIWSDKDAKNASRYDDESSEDEDEVAPNMTSVASNMGMSFLDSLDDLVSSTSKSKKEEKAKPKKTPKESKKNDKQKRQEEVMRREKDARERRAEEERRLREQVRIRREEENKRKKKEKEAEKKRKQRVRRKIFAFCKLHWERKQEQKRYRSKRLVAHWGQRFLRGKQSRKEWVHKLQNRMVLAERYTKLWEPSLKTINDRFKRTKRPEDQAIHSWAACLEGLDFVVNSEDTNDETAKILSDAADKALHIEEEYDDDGQVQDDTDYDAQMDAVSTSSSGTAPTTATNSAASTSTQGTTAKQRNGDDDDDDDDFTGTHTTIMYTENVKKWLRGPAGGRYRDLFVKRMKQLSRGERSRILAKRLKGTSKTVTVFETYLEQKSGKRILWQIEGSNLLVWFVANHDNVSRLMKLIEDSQNRKNRRLTSGDELVHDKDSLAARRNVIEREAILNPLGNTPMKVYEVSLEDVNDLASDKVWVPKLRLTREERDVVETGGTVLLLGRSGTGKTICTANRMDYDRNQTKNDPNFTQLFVARSQKLCAYVQAIIGNPPGTSFETYDKLKQRLEQELPTNEDIRSSFPTELKMRFDVFKREVYNVGQDIDPLLAWTSIRSFIKGSIEATLKTGLAKAISEEEFLDTTVFSSGRCSLTVDQRKIVYPIYQKYVRFLNEKNMWDDCDRILALLLRLELCKVADPEKYHSIQMSKIYVDEVQDYTQAECLLFFYLCDGQGNLFLAGDPAQNVVQGVEFRFQDIRSVEYHIAKDNNTVMQKPKKVHVNFRSHAGILNTAGSILTCMFKAYPKSAENLGEDHGVFVGPRPGVFEKVEVKVLADLLANKMNGTVVLVHDSTLQYWKEALGYPLIRTIRESKGLEYKSVIILDFFGDLCHQVDEGVQKAWRGLLLRGEVDGLSSKYPEIEAHLKLLYTAITRCIEQLFFVETADTMPGKAFVRWLTTTTTSWHKEKEKSAEALATKNKVLDVQARVMTKDEALQSGIQLAAAAEAEGRSDVEASKTLLDQAIYYFELADESMYKKKAQVHLESIGIRSNLPPLPSSSEEEKEDDTAYEQYRDLESNIARTVGKLFDEGLLLEGRDLCSCLVPYVPKRTQQRLKMEIVGPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAW2</accession>
    <name>A0AAD2GAW2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002336">
        <property type="protein sequence ID" value="CAJ1967610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="184" mass="20652" checksum="1456419A7EBB83B5" modified="2024-05-29" version="1">MFFNESFSNLPTSTRASHMPDKSAIYFNGGKRETATSSLRGDAMRKASSIKFAVIEEHADQPPQNPMRQLSHSFLPCLTERAESVRSLMASTRFTESDRSLVFEGDQLMDLPIRQLSKRSLLMASTRLTESDRSLLCEGDHLMDLPVRQLSKRSLMMGSTSFSGSDRSLPYRIVSPLQQACPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB51</accession>
    <name>A0AAD2GB51_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB51"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33840" checksum="54BA679C0BC9F879" modified="2024-05-29" version="1">MLIVDGQAARFLTQLVDYARFYAVVICTVLWATNEQEKRLVCWKAALMPVAIVTSHTIMEVVYGHILGPNTLGQSKRNQIRKDERNVALIGGVALLVFQMSCAVGFLTYIGAFTPTFVHDKSNLLDWTLALSTAYGEFWILSWLKDVTSMHFVHRLMHNKNYKYLHRIHLLHHSHTTNLNNINGALLEPVDLFLENTIGPLLLVVLKCLSGYPPKISLISFLYSISAEGSNHSLNPYSISYYFPPVDFFLKGNLAHNLHHTSPNGHFHAQPWHHLWEGYHKDLEAYNRIMKTKVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBK4</accession>
    <name>A0AAD2GBK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF282">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="519" mass="58349" checksum="F7BC5D419B654106" modified="2024-05-29" version="1">MIESDRICSAAVEMKQTEDHGMVLVSTKSLEPGPLGLIVFRETALLSIRTRGSSLDESGPVPDYLAEGPQMWTDWWYFQQQPKDIRDRILKMYQETDCSQADAIRQHLNETVEKKQGQHRECEGTKLDEDDSRRDDVLQNIEDFIKLAMVIRFNGVELCPPSDDGLGPGTDYGFGLFEVACKMSHSCRPNCAWMTEPDGASKQIRAITKIQAGEELTVDYIGQPLSPTHERREELLHSKGFLCNCVRCSNILGDDTRRFPCMCQSTTTCQGVHLVHQQLASSIPRLLPCSVCNNLATDDYTERMLEEESRLQKVIEEIKLVADEGGNGYQLQSMTKQIEELNPPHSCHSLAEKCYQLQSDYYNQVGEYKLAAEACYKQIGCRVGILGEGHLCQGTAFCNERLGDVLQYVNVEEAEEAYKRSVRELLVMRGGAPDPYSKCALSKLLNVQSTRIRIELDHLPHDRCLKGIADAPYSAPYPCVVCGNGCTVLGEKLEGARYCCEEHQQMHLSMVGRWETPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCQ3</accession>
    <name>A0AAD2GCQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS24177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002469">
        <property type="protein sequence ID" value="CAJ1970154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="569"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="653"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="695"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="822"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1970154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="930" mass="105156" checksum="AF622193959FB7B0" modified="2024-05-29" version="1">MYSNEDDPAKARHPNEPLNTILTFLMEEIMTSSSSSSSEDDDNTTTMELRQETKDFLNTLSQYLNCRQTMDAKYNELFEESQEIANFPVRVHSGGILEQGRGSNRNSSYQFKPEYLQQSIQGTPAQTLDELYEAAAMAQPVYQQLMKGIVNQILQSSAAAAAAAAAECDDNDEKKSHDIDVHLVPLKTRDRALEKAEDDYAQRLPGPSLCFLYDIVRGSLEFSSAKNFLQCLELIENHPLIHIVKAKNRFKNPSLTGYRDVNLQIQIPIESSSSSSSLSAVNNISFKHICEIQLHHKELKRLGNELDSHKHYEYFRSYFAGSTNALEERLEDLKVICQGGGEGGAFLQELLEKDLDEERLERLGKLFHIQLMELPMAIRAYRKLLDLQVEKYGEQHVAIAKTYHDIAGILVHQGKLDRAMVLYQASLGMKRQLHGSENHPSVAETLLRMAMVLRDQDKLDESMVLYEKTLKIQKQAFHKDHLSVGNTLDNMGMLFKKKGKLVEAMDHYKNALRIIRANVGDEHSAVGEVFGNMALVLHLQCKYEESLEMYRRSIDISARALGEDHVAIAKTYHNMAEVYQDQGKFSEAIELFTKSLELKTKRLGDEHKSVANTYTGLACVFQKQGSYDKSMELHHKALDIKEKALGEHHSSIAKTYCSMAMVLREQDRFEEAMDLLEKSLTIRKEAYGPNHPLVAESYQFMGMVQKKQDKLDEAMENYNLALEILEGKFGRKHGGLGRVLHNMALVRQKQQGAFEEAMSLFQESLEIDRIVLGQEHPLIAKTMHNMGEALQSEGKLVEAMDMLLNSLEMKMHLLGEDHPSVANTFNAIAIVLHKEGKLDESLAMFQKSLELKRQHRGERHSSVAKTLKGIASVLRDQGKLEASLEMYQRSLDVLLETLGEAAKDTRYVQSAISELETGIDGPCVQIINNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCS3</accession>
    <name>A0AAD2GCS3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002474">
        <property type="protein sequence ID" value="CAJ1970184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCS3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31419" checksum="A4D045E7E6CD58B2" modified="2024-05-29" version="1">MTDCSPNHVPAAPTPLGKDLNGEPWSQHPWRYSSIVGMLIYLCTNTRPDISYAVSCAARFNSNPKVSHATAVKTILRYLKKTSDKGLIVNFNGTLDLEAYCDADFAGLFKSEAPYDPAVSRSRGGYIIFLGGVPLIWKSSLLLCITLSTLKAEYVQLSRSMTVLLGLKNLIEELLPRLQLPNLTAFVCSIIFEDNAGALLLAISQQITNRTRYLSQFYHHFWSFVHRPQDGPPQNNPNDPWHDGKIKVSKITTDKQRADIFTKGLTQVPFERNRFSINGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GEL2</accession>
    <name>A0AAD2GEL2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS24506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002524">
        <property type="protein sequence ID" value="CAJ1970490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GEL2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041913972" description="Peptidase S1 domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1970490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="399" mass="43110" checksum="4CEBF4497CBD12AD" modified="2024-05-29" version="1">MTVQFCVQVVLGFLIWGIVASEGNQANNANNKLRGRIRRDTPPSEFDEIDFDFDGLDEIEWTRGDEGGEGEAVQQIVGGEEANLGDYPYFVDLGNCGGSLIAPDLVLTAAHCGDYRGYYVLVGAFNRGNDSTEGATFAKVTEWARHPYYDDDSAKNDFALMKIDPPVYLDADIVLTLNEEGDLREGESLKVMGLGSLEEDADDDGVGTLRDVTVKMIPTAICNGEAWYDGDIDYTMFCAGYQEGGSDSCQGDSGGPLVRVVGNQHVQVGIASWGAGCGFRQRPGVYSGINRASVQWIKQIGCTQWDSSGSFCRGSSGAQGGSGGVIGSVISCAWNEKEVDFTLLTGDDTGVIGWEIINVAKGKSVLTQMGSEKWETYQTRKCLPQSPYILLMKNYRGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHK3</accession>
    <name>A0AAD2JHK3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS13253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018362">
        <property type="entry name" value="CCAAT-binding_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00686">
        <property type="entry name" value="NFYA_HAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1951818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="254" mass="27482" checksum="8284A7482ED5AA7A" modified="2024-05-29" version="1">MITAANAQAQQQAQMAQPQQQQMNHMNHHHVAQQLHHLPQSHQAATAQLVHPQSAQHHGHQHNGHPGVNIPGAPAAPAPHPLQAPQGGVPSAQMIWNHQTAAASQMYAAAFAAMGAANQVVVAAAAADTSNAAAPRPTFVNAKQYRRILKRREARAKLEEYYQRKQAQMKARNDKKPYMHESRHRHAMKRPRGPGGRFLTKAELVDYYKDHPDEDPSRLQDTMGSSPTNETAADAVAAGAAAAAVSNKKAKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHP3</accession>
    <name>A0AAD2JHP3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001780">
        <property type="protein sequence ID" value="CAJ1951100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHP3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="92" mass="10880" checksum="131045857A0F0BD9" modified="2024-05-29" version="1">MRPWGCTFFVYVYYGAPHRKAARCKTFWNRYRKLIPIKTLQFSWSNSTSNVLTKFRNYVLAQVKLQKNTLLEQMKSVFFRILMGLPIGPGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIB0</accession>
    <name>A0AAD2JIB0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042085080" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="4">
        <location>
            <begin position="371"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1953690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="68077" checksum="080C8A8BBD1EAAD0" modified="2024-05-29" version="1">MSSSFIFSLFLATLVFTNERMIHASSAVSVAPDLPLGEINVLVLTDVHSWLAGHGRQEENLNADYGDVLSFYENLKTYCDENDQDLWFVSNGDFVDGTGLSIPGDPSSLVPVLQKMPLDALTCGNHELYIDDTVDYMVRPGGWADWWGEKYLTGNIQVTANGEIQQLGHLYRYLKGKHSNLLVYGFLYNMEGACESITVEKVDDVVKMSWFKEALTREDESIDAILVLAHMDLKDPLVTVIRKAIREIVGDSMPIQFITGHTHYRGEIELDDWSHSFEAGRYLDTIGFVSLPTKATAMATPPSTTDGPVENGFKHVFIDANKAILAGHLGIKDPKDMNTEHGLELSEFAHRTRQKMGLLDQIGCAPHDFKARAPLDDPKSLWGLYKREVLPKIFFKEESDGIMFVENEAWRYDLFSQSPLVVDDIMAVAPFNDTIVFIGEVAGSAILELNVSLNERKGSLPHYILAGEIDNKDKLYDMYTHDFNVKEVVNALKKTVPDQEYEPKTTETTSTLIWLAFVRENWPCHGELGKDAPPIASPPATLSSYIFQDDDGIATESCPTIMLMMGLLLMTILLYCAFGCTKSTSTEFVLLDPKEDCMEAQFEDRVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ10</accession>
    <name>A0AAD2JJ10_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ10"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="244" mass="27511" checksum="001AF06AE3E8E177" modified="2024-05-29" version="1">MSKKRPGVEASKRLSEVSDCKVWEQVESQFAPLLSLALKEEIRDCNKEYDNLKAKFSADSSKDCISKEELMAIVRWKFSVGKKRPALMKHLNSNTDKFVKQCSENAIAHARSIEASDAWSDDDIKCCINHLTELSGVGPATASAIVSMIRPDVFPYMYDECIDTFLPRRTYTLPVYLEVAKACTQLANELNGWTTARVARVLWVAARVCASNEGMKDYTLNKSKTLKEETNTPGSRSNKRRRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJA7</accession>
    <name>A0AAD2JJA7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="435" mass="47847" checksum="CC27ACBF9D1A6DBB" modified="2024-05-29" version="1">MTKKKAQTEKRRKADRERKRKQRGTDPTLPRQQWKSLEDLTPAERVVHRLKQQYDSAKRVKARKGKKRETNDGRLESVDRGLTIVMADNRDAPQGDSNNNNNNKENEEPKPEAKIANDDDSDNESIPFAGTKSGKKAAASRPRRTTTSSPRIPFGSPSNVPAGNTDLSTLGSPTQGVPRAASAPWSSPPITCRTHASDGTPDEDGLDQEWGDDYCSYSPSDPSNEGLQNLQEKQGMNFEKFPFTKGTKGTTTLKRGGAAFTPDGATPQKRRRSEKPSSAAKQPSTKATKSTTTLKRAAAGSPDSCTPQKRCRLQMQSSAIQEQRTGDSPAALFSPILFETTPFVFIPGNRTFELNQNVAAPPSHAPDYIAFDSTNGTSWIYEAYASAREAAIEVNARLGPLRNPFEWICPNCHNTFLIPQKACPACERIKQGKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKH2</accession>
    <name>A0AAD2JKH2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKH2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042013407" description="SET domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="148"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1958204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="656" mass="74123" checksum="3C3920633BAC28CF" modified="2024-05-29" version="1">MKGALVIFSIGVLALLPNVTLCASVKENGDDSSSEKEDNSKCGLFLAPSSIPNSGLGMFAGHGGISENATIGDGDVIIPFFEMEFHNQLKSKKHRNDFLWDEYVWASHTFPGAEQETEDLEDAEFACPGIGSAANSYLALKNVLDQGVSLGLGTDPGSPGAGAHSPYHNRYFTATEDIPEGGEVWMDYGPAYFKSRVNEYGYIPLPESYPVADDLLIDYQEMRFVDCNSSDISNQTWEELYQTILDFAPIWRTSRVLHALPTNASKIEDILNDGGTTYRDYDASRRDLAWLDEHGQCMDNIKTGMMSQESPHAGRGALANRFIPAGGLVTPAPLIHIGDMDELKMYQRTTIKKARFESKVVPDMNGPTTYQLILNYCFGHMDSTLLLCPYGLLTALINHSSKNANTRIVWSDAMRRKEWLEEPIDEFADESIAGLQFDFVALRDIQEDEEILIDYGDEWEQAWQEHMQNHQPRDGYIPAFELNQRLNEIEFRTLDERPYSDDGIQLRCRIQHARQCFSPRSEHLKKDSIACAIIEKLGENKYTVKVLEDGVDDDLQLEMPADAFFFVDLPYQRHHFSFQAFRHAMMIPDDMFPDVWKSRTGDDKREAGSQEQDEEDSSDDGEDEVFVDEEEDASAFKRKPKGWKHDDSAIIELPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL37</accession>
    <name>A0AAD2JL37_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002056">
        <property type="protein sequence ID" value="CAJ1960258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39657" checksum="52B25238DBC5202D" modified="2024-05-29" version="1">MKRLRVSLYQAIKKQFDTRRNGAQLQRNHKYERSIRERMPNLAFQQVGNTNKGEYDAFEELVVARVIQQIREGVNGGIDGQDGVSFIQQYYLNKGLRIFKERGKDAAVKEHDQLIKRSCWTPISTEKLRPTERKKAVDAMMLLAEKNDGVTTKGRCVFKGNKTRDWLSREDTASPTALHEAIICTGVIDAHEGRNVMSMDIPKAFIQTLMPEQEEGEDRVIMKITGLLVDYMIDLDPTYRDFVAIENGRRVIYVVILRATYGMLQASLLWYRNLRASLEEYGFVFNVYDPCIANMMVNKKQLTIRFHVDDVLASHMEQRVLEDFFTWINERYGGVFSKGMSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLT8</accession>
    <name>A0AAD2JLT8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="838" mass="95682" checksum="C8B2D6FAEAAF095A" modified="2024-05-29" version="1">MANEEDDSMLYKSMLNKTLGLPDFNQYSYLFEDENGDDTESLLNTPSTDAEMSGTAADMSDNIGNDLLSATGDSRPTESFSQALEISITEPKGINQMTQRNQQLQNYWENQQKESQLIEEKLSNIRDRVEQNETKWEKEKNRLLSPQSRIPKPGRSSASALELQLETEREKRMELEVRCSALNRQLQTIQKDVESKSSASLRLETLKQMQKRHAEEIEEVHEQGKRARVKHAKELAELEDALLQSRQHNKELEGKKDTLILEIEQLKGAQQLHKDEMSALQEKIQEQIDFRVNIEKEHDRLDEKFKRQSLDMTSLREVVSGKEEEKAAAQAKLAATVLEKQQLQDGFDVLKDQKQRAEQEVKNLELQLIDTEKKCKEENVKTEIAIEQCEDLKSFIHEHGPKAHRLELEIQQLQENHHIITDQLKAEVEVYRCQMADLKEKYEEERHEHRKLRTKLEQLHGSGDTNELEDFRKQEDTVSDRHASFQSETMGKFANVEHRLASGSSIDSSLQNHVTRIETEHAEEIQELLQGLGQGQPEATDWSSHFESRNESKGDFSTPFKVKSKSTDGNLSGVVLSPILRVEHSETASMGSDNVERKIDGLLEEIDQMDQEREEMLGELQQGAPNSENLRPSDGSRLNEVPTKVSQKMPNDVSESPFSEHSADSDPPSNDLLDGTILLLNNLKDLMDGQESENEKETSVLDQLEALSEMMHGETNLSDFLTGSRSINRSSVSAMRESVHSRASGRVPSSPLKSSTVHDEEFDAGSLKQKEEIWRMLVAELRHRILFLEHDRNEVVRLTGSLLERERDANRLRLQSAMSSARREAFEEFQSLLEVGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMB5</accession>
    <name>A0AAD2JMB5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMB5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="357" mass="40891" checksum="FF1E1C0F8863E03E" modified="2024-05-29" version="1">MIYTTPNKGSRKMVGFIHMPTETREVQNRSGLSSEAISNTWYSQAEISATIAENSRACFLLQRSKYLGETDDFCYRGLESIFMPDYRVRRQKVMNDAKDAVMNEQDRQLTSNFFDADLIAATYREAVLYATTIARHRGVRDEEEIKDAPKTKSLELDAPPAKKNERKTGLKVKFDESESSRLISCRKDLSEEEKRACWLKRNEYLSIKIQAINDINLFMHGQAHESDDFTIQGLEKYLPNLSMIRKRYRLQAVNAVFEEQELQELEGKSCPMRIAKTYQLNSIHWLLIARQAGLDSGSHSTTSNRKKMPGKSHLTQTPVARSGNQSTSSNNRKMMLDKSSLSMTHRVGKQFQFLSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNC0</accession>
    <name>A0AAD2JNC0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002308">
        <property type="protein sequence ID" value="CAJ1966644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="127" mass="14293" checksum="FB9657726152E36A" modified="2024-05-29" version="1">MLPPLNRHRRSSIILRLHAAMPASALLLDCPFVPSLHASADTDILKLSCLCWMLILIEHILHVNGYIFKGLVIAAEFLHISVLRGILMDTDTIRFAEQPINGHQDLYLDSKHLASRHSAAIHFLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPE4</accession>
    <name>A0AAD2JPE4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPE4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="1">
        <location>
            <begin position="62"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="390" mass="43678" checksum="8F2C2008F966E306" modified="2024-05-29" version="1">MLVPRFHTFAGIFACSISPGRALVSTQRRLFSSTALKSHFDVPTENTQKKSSNLDHGSTTLLVCGDGDLSYSAGIAEKLAKSNINMVATVLEEENIHQTVYKRSLENSESICKHEGHELRFGIDATKLEEFFPTTRFDFIEFNFPHWRGKTNHRHNRQLLSDFLQSASHVVKPDGEIRVALCDAQGGMPAASIEEWKRSWMAAMYAGSHGLLLKKLEPYAPDYELSSHRGVDRPFWLGDSPQQYTFSLPDGDVIDEELQISCRHELRISLDDKLEQCPVSYEEIVVGDAVEKLVQPFIPDGIDFQIAARELLTSDNKLKAGDPPLAVFLLNYSGASMPLSRQDADEIRKNIEATVANEWKLDIAKKGRMVSKPYPSVLLPSLIRDIAVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPN0</accession>
    <name>A0AAD2JPN0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002480">
        <property type="protein sequence ID" value="CAJ1970211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="83" mass="9436" checksum="AD575537426E67F6" modified="2024-05-29" version="1">MARREKMRQTIDDADHEVDHVLVRAANIQMIRNMPETDAALTKGPERKGGMDVEDDMRAPFTLQGSDYVKVEAGFCPRSWESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUE8</accession>
    <name>A0AAD2PUE8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="334" mass="38220" checksum="C2C246E2A0A41A69" modified="2024-05-29" version="1">MDNSYHQHVPTENFCDYGRKKKEEIDIDEHCSVHSEEYTLTSSFTYEEPLSTIAEEKSVDLWTKGSDMSMPDLEDLDSSCTMDSPRVEGKSYKNRLYEKFYSETRADECPVDSLDLTNHYTQYHGLKTSPTCDYAGHSHRSSSATLSTASLSRSSRSSLSAHPSTAKQPQIESMRNARWDPEITDTPDEEGRHLIGVKIQFFRSMEYGSILPMELPICAYADSPSSLNPGSDETKSEKTRRDKKQKKTKENKNNEAADIKEETKMKSKKVETDRPRRHTKCESLNSGPDADNMKHTAMKIHRRSIREKIKARMRSIDKTLSKVRAIESNREIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUV8</accession>
    <name>A0AAD2PUV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS13733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051084">
        <property type="entry name" value="H+-coupled_symporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="27"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1952821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="476" mass="51403" checksum="8D5AFAA0B4832418" modified="2024-05-29" version="1">MMAEEDTDETTREDEAFFSRTRESWFNTIAGVMGNVLEWYDFALFGFFSDIIAQVFFPPAPDNDQGGVTNNNSNLIISFVIFGGGFLVRPIGGLVIGYVGDKYGRKQALTQSLFLMAIPTTLMGCLPSYQTAGIISPICLCICRLLQGISVGGQLPASLVYTVESRDPSQWGFYGALPMMAANSGTLLGNIVGAVMKDTLTREQLVNWGWRIPFSSGILIALVAQWLKKYGANVRTTAGVHDGADAPIQNPIRLAFAKGNRVALLSSSLVPILWAGGFFLTFVWMVIYMSRLLDPPIPDAFWINATSMVLGLTLMLPVAGALSDRIGRIRVMSVAAIGLTIGGPILLLLISQGNAHVAFGCQLILGLLLSFFGGPLSAWMVESFSAEVRLTSASLGYDLAHSIVGGFSPAIATALYDSCGQTCAGSLYTIFGMISLVGLYLNFFCGNGPKRQLEEPVSIDMEREDHETTQELPEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVB5</accession>
    <name>A0AAD2PVB5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="754"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="915"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="974"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2518" mass="282891" checksum="FD838932DAD101D1" modified="2024-05-29" version="1">MESSAVSLKAAIERQPSATDATNENNDESHPSDIAVGRMVEVLPRTWPGINKPGGVARVIKLYVIEDQIKHVDVHYILARTKEKQVPLDYVKLAPQYEGTANTRSSSRNQPTSSLRDRSMLLGRCKRCGSLRTDCGSCDWAFEEMHQQRILQQQEQMKQDLQNSPFRKNASSKYRKRRRGQRTFNNDGTSSRWEPLAVDNDDDSSLGSWDDSSDDEEEDDVLLQELMAQNMANYRKFRKFRVAQVMREEEEAEAQKTASAKDMVSDGFSSASDSEQEMYQSYLKRKKSLDQNKRQMKNRYRSITERNHHRSVLESIATSKNTGRPAKTITPFTKQSAAPRNDTSSHTTTSKTNDEISNTLSRQHIPPTSQQTKKRRRRRLVIQEESQDVNHLLERADEGDASDDSFGAGRDCDASLRETELDNEMNQEQEMELEQHHVTRLVRQAQEQQTNDFLNLSQFIQPEGLEVAENLPDDIVDRTRNLEYRQLPDFFDNLVTQMEDEWMPDWKLKIARLLSAKRRLEYSGFSTLTSTRGRGRSPLKAALEAALDPLQVLQRCEEIQTGLRDHLIRNGLDQCKICLHKLMDDRLYKKRRSNLNSAERKRCRGLGVMDARNLRLDALEDTVDDLVRKIREVEKVCENNLQENAPLDNGDANSTQMEMQDSEEENLKNTTLKAIRVEPSTACGNETEPTLPPFHPHMHANRRKSTQTSTRKRSQNSEVVNRYQKRTQAGHSVSRSCNRAEKRIQRVKRIRLEHDIQVNQSEEPSESIDMGESFTPDSDDDERDIEETQEDDQLPGVSMFVDTEASVGGRPKRSADEQDESSKTRIQKRAGATTRYDSKRISDQNPRSSRPARSFEQDSSVPTFNLFGDDSPQSEVEESRNYLQNQGGRRRGGSRIPISQRMQAFLLANEEGTYSFQQSMDDTSSSREQRSRASGQNRQAQESRRSSIHPDSQRKREASTSRSAPQRAFSLPNSDDEMENSFGSDSDDAIMVDLFDDLRASQYQPTPNLNAAAYSQSIVATCQQLQRQSQRREKNLEDLHTALHRVPIIPGEESLTVLTTSLALLKENGTMTLLELASTNVPNLRSHVHLLSVCLLSLNSVTECTESNFCPMVKRVVENRKAFFNMLLLQLIDTMYAVLHPSAWSFKSKRRAHILRALKPLRNSLAKVTALTESACRCILEHFGCQKWRRGLTNGLAFVSSIGASEWKEFLLNGTFPQQVTDVRLKQLGRVWPRVEIETLWSIFAYLGECSSRVDEGSVSCWQLLSKLFSSGVLFENDVSNDTAPAKSLPPSVEHLNTCEQEIGFFTDLLSKGVMKGVPSSDSMLVNLIRRSLTLEGDSYQRNKYARKKSIPKMSHGKESKRLVARLWKAADPSNFLAPDRIRSKNLPSGILSLGKAAEGEAATVKNSLLPTSNMLRRCLELIHVWIKYLPQKKVRRNRFLKAVNTMRAALGSVSCTTPRVVSPVKSNSFEAAFAVQHEKDLLVDGAEHKQTFMIEAVAWTKIIEQVALSSNDAMHSNPFVGTKSMSVAMEIWDIVADGIMKERRVALIEKQESQGTCTSNLRMFAAAKVMASIAMLQMNICPWFLDTGEKVTHVWDNSEIHGGVTPNHDAIVFTVSAVLACLDCLGDMRKSPFMPHVISIVTLVFTNMAAFFQLSVTERGAVANSQLKELSSSVLLKTVKVLINSQGDDEDAVCFQLLLSAVRSFASAFLDSGCIHPKGASAGVAQGGDAVQENDVDGGDIWGSIDDDLLASMNLDGGQAPSPGFAQELARTLKCALQQSKPSGRFSVPSGFGMTNLLQMSPHGRHFVASELDRVCQCLVSLQLAGPNLGDRAVLSDLLCIRVQSHFDDDSDSQFWVQISQTLSIELINLSKAFAICSELVKVNFERVLFNVLGMLFDSQRLEVYPSCNLERIRKYAGEEIGEQALDMLDIFNTCDSSSLVGTGIEAVAKIQRKRRRKAERVWHMCHQISHALLESESDHGALSLEGRIGSILQDKDTDLAQKAPSVLDSSSLEKEALQSFQILRTLASVIDRNEKNHAVSMESVLAFSLSIIISQSLRTMKSLKYQESIITRDSSNEQELRKIMTEELLRTYLEIFVALVAWIFRNSRDGASKQWTALELHLRDNFLTPILRRRSVDLALTLKRILRTSLTVVTGNSDASSATLRLGSISGFSNYSDGILDSIVRRSRQLFIAISRQSHFRSLQSSLLEAAIGCPEGDKELLLPRYLGNVFNTSLEMKNGPDVSPLGEGIDEYLSFVEKKVASDADCLKKSSFLDGLILPRLNHGKTKLTIKRRNLCLVGHLLEGEMSDPTIESTSIMALVKGMRRSLLQCFKEPVIDNVFLSEALSCSNRLASTPVIMDDSRQEPLLSWSRRSVDFEIPNDVAELSAKEQNGVYVWLYYKWLHSVGKIIVDTSEAGSGKRTSFRKLCKNDEESGIPMDLSQMMQEMDLKSSHQLLCHVEGVLFPSRDENSASLANVYANERLSQDSTSQQVEDWKPTAGVRKCAKELMAEVVAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVS6</accession>
    <name>A0AAD2PVS6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enoyl-[acyl-carrier-protein] reductase (NADH)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS16565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVS6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.400">
        <property type="entry name" value="Enoyl acyl carrier protein reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1957138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="28208" checksum="DF9320E0088E7611" modified="2024-05-29" version="1">MSPPRTALIMGVSNHRSIAWGITKSFLEKGWQVVLTYQTDAIQSKVETSLIPKVGGGRDGNNVLGGFACDVSSQQTMETTLTLQLADLLKDRPLDAIVHSLAHAPNLKLPLLETSMEDFTKAHEISAYSLIGVARATQPFLSTANSSITALSYLGAVRAIPGYHSMGPAKASLEAVVRGLALEMAVTQTRVNAVSAGPIATLSAKGGIANFNTMLEDVNQRAPLGNVTQEQVASTVEFLASEGGTGITGQTIYVDGGYSIVGGPASPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW35</accession>
    <name>A0AAD2PW35_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17599</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW35"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="391" mass="44309" checksum="54B169BB3558C21B" modified="2024-05-29" version="1">MMENEGAGQRSVSRIRNPAGKKSCKCVVTKKTRGKNGNNKNVAGKPSACVGRNNQQYIMVAKIQRDVDVNTSAANGMSHMGPGTEYFVTLLNSFVEKYWEARLEGKQRKLCEKIVNTIQGRGGAFYKKAKGGYTRLDFESALKATDESLNEILIVKGKSKKRGKDDDIIFTATERVPKKHVVYGTNKWENSLFTPSHLSRYSDPNTSPKERGTIIQSIFEVLTNKFEKVLDPLSSNRLYVVSPCKWKEMIMGMLEDYKAEKEKYPNLVIVDAIQDDDFRPWKIDDSTKGSAIVISQVAKYNDPRASQTDKTNLLLNVSRRIEAGGGKIFEPLLRFNQYREIDPRFAVGTLQRFVERHTAFKMRMLRSEKYENNLFRAEAIGAKDVLYGSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW46</accession>
    <name>A0AAD2PW46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001985">
        <property type="protein sequence ID" value="CAJ1959270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="342" mass="37039" checksum="2CB58F93CB2480C6" modified="2024-05-29" version="1">MEEDYPRDGIPQPPDIAKRTRCYKLNLNAEIHPISPSFVGPFDDVPPPLTFSTSDDSSVDVTTTQVAIRTAKIFRGITVGKDGTILSQNARATRSNRGSKNKKGEKSRQASKIEKAKDLVEESMLTGKAPDSDEPANMLSLVVMGEFDDMKHLVRDGAKKLRDATDLPEDTLLNTNSNREGMSLRSPRKRISPNHVGGHRGSTLQTPNKIRPVGLPQSAPPKAKVGIRDRPKYADDDNRFRGSSGYHDASGSSREVAPNHGEGDWSNTLSFSRGFHSIWNCGGVTGDDSGTTSIVQVSNRRESKAHSMGGAAAASPTNRGVFEGRDSNMGQVRESGIVSRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWF5</accession>
    <name>A0AAD2PWF5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS18719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010196">
        <property type="term" value="P:nonphotochemical quenching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009644">
        <property type="term" value="P:response to high light intensity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080183">
        <property type="term" value="P:response to photooxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3460.10:FF:000012">
        <property type="entry name" value="Fucoxanthin chlorophyll a/c protein, LI818 clade"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042254741" evidence="10">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1960414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="194" mass="20659" checksum="B858754281B704AF" modified="2024-05-29" version="1">MKFAALALLAAPAAMAFSIDTIPGAIAPTGLFDPLGFAAKADEGTLKRYREAELTHGRVSMLATVGFLVGEAVESKTVIFNGEVTGPAITHLAQVNPVFWVLLGAGIAKAETDRAKIGWVEPKDVPFDKPGLLRDTYIPGNLEFDPLGLKPEDPEAFFEMQTKELQNGRLAMLAAAGFLAQELVDGKGILEHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWH9</accession>
    <name>A0AAD2PWH9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002078">
        <property type="protein sequence ID" value="CAJ1960888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="112" mass="12931" checksum="4C4158736E293269" modified="2024-05-29" version="1">MEYVKTLYQAISEENRSRRKEMVCLKTPSSRREMASLQTYQAISENNPSSRSEMALLNNPTIHWQRHLITTDLSSHLWGESIKQKRNGVALGVFNCCMLRLSRRMVTVVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXB1</accession>
    <name>A0AAD2PXB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS21390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40855:SF1">
        <property type="entry name" value="CLAVAMINATE SYNTHASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40855">
        <property type="entry name" value="DIOX_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042125120" description="Copper transporter" evidence="6">
        <location>
            <begin position="23"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1965798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="79084" checksum="96543FFD7EC5054D" modified="2024-05-29" version="1">MQSFNVLTILLNLFTLVASSQAQETAATAIHSRQHVVPTFSLDEIQLGHRLPELSEVLRTTGLFAVKVSPQSSPSRLEAMNGLCQCLNDNHNDHNHDFHNDHHRQQQQQQQLESILLPDGHTQRTTIATATIGQDPLPLDDNGNDIQLLCGSNTVNAMETVRDEVAVVSKAVVQSMDRLLLGDVVHGGGGGAYDKRNEGPLLETKYGSSYRTMASIVHSANHLEHFHHYQQKKKKNNNKTRTEPSFKTVEWHTDAGLFLTFLPAHDCESGGTNQDDSFWVQLADGEQAQAYFEPGSVAVMMGAGAEHWLHQSISPILRATRHAVKMTKNTSRVWYGMMHLVPEDSIIQESPQRTFGDMKQNLKVSSSQQQGQGAMDEETVAIGCGPSTDDDAAFPLYTAASSSSSRRRRRLQHVQDASACNNVTNFFCWTQCLEIPNYEQAESYVNEGNSLYCLDPGILAKSGNQVPKAVEPCIGKVHNSNCQGIWHKTSPSVEGWPVEYNSTSQVEEKYCYGGTSMYMDGFHWIHDTTCVIYLFPSFVLSSQARFIGACFGTILFGMMVEAIIFRRRKSIVNFEPGMSRLLASAGFYALQLTMGYLVMLIVMTYSIPLFLCCISGLVLGHVVFNARDALFNRAAKSAIAGGVQDETIDNVQEGGCGCHEEKQSFSATSTEGTQQEATAQSCCSSNNTKIENKPAVQDRTHGVPEGSTPCCQNSLDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXF1</accession>
    <name>A0AAD2PXF1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13915</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14845</name>
        <name evidence="5" type="ORF">CYCCA115_LOCUS18329</name>
        <name evidence="6" type="ORF">CYCCA115_LOCUS21757</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001136">
        <property type="protein sequence ID" value="CAJ1943790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001823">
        <property type="protein sequence ID" value="CAJ1953195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001861">
        <property type="protein sequence ID" value="CAJ1954250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002029">
        <property type="protein sequence ID" value="CAJ1959910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1959910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1966174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="626" mass="70153" checksum="4CE337947358D86D" modified="2024-05-29" version="1">MFDPAETNATEIFQLQRADDEESNRRLDAMKAMVPMKLFYNRFLDGWNSLDAEVQSTVPVDDKAAVSRAYAKHILSHYLPEADLTDAKIDEFCNDVHSFLTLYDKVILQQVKGAHLVLLNAKKGYADKFPLGMQSVMSLAKIDAEFANEALELYDTDLYAVKRLHGTFTRGGLTRDLLELCNFKLSPEETDTKSCFQTRVSVKVDYTRENWRKIVKDHKNRPNKAQVNVDTFAATSISDVAVPASNLEFIVQQPVATVDSINTVNQYHPQIRNDLPSYHIDGPIETSAETFAPTSVHDIAIPGIALDSITEEPAANLDFINPSCDLDAKSVDHVIASTATVYRGPDNEIGQRLLTMEQWQKIFNGKKEKEESKAEKPTFQLIAKPLTQTPVNKAPEVHQEKVDKMAHGHMAARKSLPIETTTTKIVEGTEVAAKNPFSMDNKSDNMKCPLGVDSNIKINLEASSKKDVLEEKKIKEQAAAGNKEPKKKKKNEQSKNTKKRSLPDKKKNEAPHAIFPGCSKHQRKLIDLQVLEHSAFKSYIRFPNNTSLGRLLPDSVCKGTCQRNGRSLLSITSGQQLVNIHFCKKCSDDDQEVLSWFCSSCYNDKNKADEAGGRVSKRTRVPKRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY47</accession>
    <name>A0AAD2PY47_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS24039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002447">
        <property type="protein sequence ID" value="CAJ1970015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY47"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="700"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1970015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="794" mass="86365" checksum="F16A23CA6F32706B" modified="2024-05-29" version="1">MEGMENDDSTNDALSSSSRQLSDLQEKILAILPLPSAMISVIGSTMILYIALESRAHKQWTPYTRLLVAMSLCDILYSISISISSFLRPQETSNFVYALGNDASCNASGFLNQLSMSAIFFNSALSFYFLATARFGVSAKRFSRRIEPIMYVICIGHPFLTAAVGSYMGLFAERRGIMGCWLEFDKRCTSNDPEILATAENCTYVYTGVIFYVLPAGGTLISLVVNNLIISRFVSSKVKPFSRRGQGRQRPTSPLERPSSSFDSTTGATTDLDATTTRRSDVTSLSVTHVANPFRTGVLLPQEPSTTTDSDHQQLATQMAQHRRLKLVKSQAFLFVASYFICHIWSVGMALGDFLARSDRAELEMMVDYYPIALLQAVFQPLQGMLNMLVFCRPKYLKWRTEYPWETKWWAFQRSIFGERIRPTRRGRPASKPVEGEDDAEEGGRPEHFSSSIEEESKQAKGDAISDGDASHTSATLSSASSANSFYRTREGMSTLTASLGDFDHVIDDGVQDERWAASERSDSGLTGAWVPIRRSRQSTSTGATTRGSSLEVISEHAESVFETFPTATSINTSVTAAAKNQQQQQQQQQQQEQEQEEEQQQQQQQARSTPISPEQRVGRWSPSSSPTGRRRKGSGVLASRLLEAGIAGDNTSTSLGTLDSPASSRWSTGSESLPSHVATAAATTTSIPLPRRVESLNDTTTSSPTATSTTSSSSSSPKSLTISPPLSNSSGGSVSSASTVSSLDTPLLPPRRRLSPPPFANDSDSSSSGDDHGNDNDGDTSDDGSCSTEDGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAS0</accession>
    <name>A0AAD2CAS0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1910716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1910716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="487" mass="54137" checksum="E7BE53687BF9A4DE" modified="2024-05-29" version="1">MGIAASIFQNNPTETTTQPKKEKVPEDVKADWVKAVDKFTKDILDPSYLHLPVRGSTLNASLLYPSDYPDHPGLMPGTHKHLGGAYDPTDGCIYGVPANSKSILCIYKNEEDGEYRMKAIPLPERIQKRQMKWLRGIIAHGYLWAIPAWADSLLCVDIDAYWGRRELAEGQTDYVNLIPLPEGHPKSMRWQWHGAGINIEQTAIYCIPSNTKQVLKVDVATKTTCFIEIEYDKEKYTDFELDCTNKWYGGIVGDDNAIYGIPYRAPGVLRIDSTNDTAKIIGPNYGVGNFFWHGGIKKHGKIYAHPSHAETVLVIDTKKESRGLISELEIHRGENDKSDRTKFKWLGGSVGADGNIYCPACDVSAVLKINPTTDHCETFGFAGTTKNKWQGGTLSTRDNCIYCIPADGVHVCRIATDPNIEGENPVQLLGNLPESKDKWQGAATGLDGSLYFIPENGYRVMKVTPPPQPPKIVDGKLPEDDVKIELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC71</accession>
    <name>A0AAD2CC71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Chorismate synthase</fullName>
            <ecNumber evidence="4 9">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS445</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the last common step of the biosynthesis of aromatic amino acids, produced via the shikimic acid pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 9"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1905983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CC71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000003">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042167623" description="Chorismate synthase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1905983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="434" mass="46756" checksum="DCA3046466724772" modified="2024-05-29" version="1">MKFIATSLLLLEAASSLSIPMSMGVGNSFGRTFRISTWGESHGGGVGVVLDGCPPRLEITREEIQKDLDRRRPGQSRITTPRNEADAVEILSGLNPENITIGTPIAMLVRNKDQRSTDYLDNDMKVAYRPSHADATYDAKYGVRAIAGGGRSSARETIGRVAAGAIARKILHKYNGIEILGYVSKVQDIETKNVDHDTFTVEDVDKNIVRCPDEEVAEKMLERIDEIRTTGNSIGGVVTCIARNVPAGLGGPVFDKLEADLAKACMSIPAAKGFEVGSGFEGTLLSGKEHNDEFYIDPETGATRTKTNRSGGIQGGISNGENIVIKVAFKPTSTIGQKQGTVTRDGQEVELRGKGRHDPCVLPRAIPMVEAMVALTLVDHVMMQVAQCELFPNEAPMELQPNPMGTTAHREGGPAVFAAESKPDKAVSQRVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCM7</accession>
    <name>A0AAD2CCM7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1899031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCM7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1899031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="135" mass="15364" checksum="1FE3B27F5452F6AF" modified="2024-05-29" version="1">MWGLLEREVWDCFVPAAIREDIVLPELRKPGSSWDSDDSARSYNRGLTPYQRALRKREKKKAKELGVVKDDGAFAFLTALLLEPEDATEGINPPPIYFEMHKIPKAPSWSDKQVDNDWLPSPPSLAYDDYNISGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCR2</accession>
    <name>A0AAD2CCR2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000091">
        <property type="protein sequence ID" value="CAJ1929764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="292" mass="32809" checksum="70736FAF495B5CAE" modified="2024-05-29" version="1">MTGWRQRRPRRTNQQLPAPEQRTAVSSTIPEQATALNSSFDLLVSNLSGMDISANSSIGSPSQIFGATSYGSHSFSSPCGFGSAPTRTRPSYPLPNYHQDGSKKWPNLIYNFPEHGHRHGNTFICQGLIEQDHIEYQTITVNCSCPPDDYKFYELKIANSFEVPACFQKHLGRILLFREPVANFTARQYQKFGIAKSDNPGAKKTVVNALKAEAVNAERDLDLFFNYSIIVFSMEQPVFANRIFSPKSDFIVDSKKSGIHNKPEDNTSFKKDQYGLTLSWKIALAGEFQEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD59</accession>
    <name>A0AAD2CD59_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000091">
        <property type="protein sequence ID" value="CAJ1929638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD59"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="486" mass="54453" checksum="0B90D9BD8496B213" modified="2024-05-29" version="1">MPDRLLPKIQWKNQNQYVDYGKKLNLNQIGTTVPATVPAIVPGASASTSVASSVAGSVVKTGYFDMSNIFHNAIKGKDENGNDVYLIPCPAGMTNVELQANWHYASEDEDLPDLATEADRGLQFIQSRRKERDPFGLYNHVIMDSGCTNTTICNVSLRTLPTPKFELFLKHLEAAVLDSMTGDGTSVAPTGSDFKFKAPVCDLFTGKPKEFWGWWQSVLLAFDQSGISEALTDPEYHNNSNSAAKASSAGRYAIAKSIQGGHTFNTEENQAHFMVHAIDSLNEIKLDHTKQVHKFINDWKQIINLLNKNKNQLVTNREILHAFEESRQFILRNPLKTIDDYLDHIRNQANSMRMLSGDPSIHDDGDIVPGVICRAKSGTKPKGSEPPKWHIPFFPNGWKQALGQGAFKRLEEWRCAAHGTTKRPCNLENEFDMKKVRNKSYDPNLDRKTKKACRGATDTEEDENSQDGTTDSRFHKFRIVSANPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDI0</accession>
    <name>A0AAD2CDI0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDI0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1924250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="841" mass="94262" checksum="E19B342AD9E1A362" modified="2024-05-29" version="1">MTSPDPGKQPQTKDATSMPLSPIVKPDGEWNTWRQSYITTAPPPSVPALTPENEMSAEKQPKDETPSNDDALEVSRQWIVNKSKTQALNGSQLGTLLHRLLCEQEEIMDRQISKPWTIIRPKLADVPQQLENDGTITDTQESKDEELSTISSFSSSQSSMLRQIEWHVVLLLELWIQHGERLVQELYPRLLVLQYARQEAQKKEEKIKRKWKRMNRPGNQNKAVKKKLKQSKHGGKEPKSSLSKFSASKFRIKQLAKYQKVMEQTPALVNRMQTATPQDKELQLLNHIATIVSQAAFFLPGNESMTAFLTSKCLSPRIWKVLPQVVTHVYDDLERSNPYLELVETEDPFPSINILTTTKKKKKKKKTLKPKQEEEKKEEPVGRPKLLQKKNRFQTGAGHFYHRSRAAQSSMSKVLEHLSPVRNKSSIALASASSTGKNNRFLSRKSSSELVTPHLGKNKSAKQGSVNKTPKLSLSSTTSSKKKTKASMTPSATTTANKASRKPAPVTTAKKEDRRPKKIKPIDPVKSIRRDAAEFPLPVQLLQTTNVQSPDCKLSRAKEEDNVKTKRSRSQGLFPLSPIPTNRSSTSESTIAAAAVLKTPTRKRRSDSLLSTTTTPVRKPYLEADGRENERNHGNKRPPNAPFLTPQRYHCQKVAETPDSSTFPAPKKAAYATPVRRRCYTNNAVVAETPDTSAPAKLLERCNESVVAETPQRQPETVAETPQHPTTTGVVAETPEQEEEVEEVNKVASIGGFDSIDWETPSSPSQGGSDVIVEPLQLFTKPPEAKKPRRVYSLGGGRSKQPQQQEKKTDKDEMKDRRMATNAVLTQAMAFMRRKSLERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFZ2</accession>
    <name>A0AAD2CFZ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000275">
        <property type="protein sequence ID" value="CAJ1933483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="311" mass="35873" checksum="C7B19AE9BC1D81A4" modified="2024-05-29" version="1">MKSNLLCVDQLQDFGIIMNDVPLQRLKREDRNQYSHSIIDENSGLHIPMDFLNPISFFACRRPALSELDEYVSVEMTTSVPWEPYDPESSRIEQNLRREYQGDIATQQIYSVDRSDPNYRSICPLALPIALGDRVEATINGVKTDGKSYLVKPEQLAQRWRISLECACRTLKKTTQRALRDWTKVKGSRRFRPTQFQLEYPRLRADIWANIKQGPCVSAEGNKYVAVYAAACQWARGYALKKESEVSNLLKEVFRDIGSPRVLRPDDAQSLTAGEFQIRPRFQYILASLTILIRTLLKIVFVKQQKCMFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGM8</accession>
    <name>A0AAD2CGM8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000169">
        <property type="protein sequence ID" value="CAJ1931674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGM8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16560" checksum="C7AB7C8891276820" modified="2024-05-29" version="1">MNSNRLADYNGGGLIHLHGMAPLESDAGIVQALVEAKRYLFLAVGHNHGNDYFCPYHSSSENNNNNSATIMDETARREHFSSAFHLCFGRHSGYGGYGKGARVFELKNRIRFHDAREKGEPHNEERNSIRWKSWVRLESGEIIDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGZ7</accession>
    <name>A0AAD2CGZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGZ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="3">
        <location>
            <begin position="181"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1934509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="55240" checksum="8BD87493B6D7E4FB" modified="2024-05-29" version="1">MEDYDECKERRDAELEFVESAYAPEEAYCERADDSKKPPIIVRKLKLLDEESSDQQGSVIMLSMMLTLPLDYPIHSPLEVDVSLDQDGSSAGGKNATLMKAALNAIPRLNESCRSIAMEHQEEESVFIVFSQADEWIQDEWPNLCREYQQGGGSNKSSQRNPHTTTKDKQQSKQLVLGRRLIYSHHIISKIKRGDMKSLASHYKLTGYMKIGWPGLLIIEGLEEDCIAFYDEIRPWNWQYLVLRGEQQEVVSKVKKNNCEGDEDDVLQSHRKFERFLEVEDMSLVAQHCREVGLENLFRTSMKVYENEADDATTSEGEWGEQSMSYGALVHVDHMNNQKGYRKWLRKTSQETNCKVLIKQSYPNHDYNGRPKIVVGIIGDSRDQVGGFLKRWRTSKVDYDSRKIACYERQMTIVVEGDLPHYYYQIEDNGIDWNQSMSEESVNLPEENLAEYLQSIGGDEWEEAWWKILRGGLSKPANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHW7</accession>
    <name>A0AAD2CHW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000435">
        <property type="protein sequence ID" value="CAJ1935005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHW7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="284"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="522" mass="58330" checksum="AEB0CBD951210088" modified="2024-05-29" version="1">MTKTIVEALTVKNPGEVAGDDVDPPEVLDTIPVYKEFFAEHEKFQRIHVHLVGLRVRDPSEDSDAGVFKASWFKTPRLTVETYGEDTGSTDYFPVGKHSTLKSQTKKGPTPVWDVKLVVIGKKETTEGIKISVSGKKDQYSFDSPASEFPAIGEDWKELVHTPAEDDATNVDFVYKVCISDCAERTVSQEDVANFLQSTDTVEYSEAVIDADKDADKAVLQIWKHKEPAKKAVLWHLGRNDCFMHPHVANPLFIDNGYDIYVLNYSANGLCNRFGFVDDPNLRSHNNIKDFNLYLSQIEKSIEMMKDGTSYDKVIGYAHSTGGPVLINYLLERGDDAFDGFIFNAPFLEWGSMNFGGSQLIEDMTLFLLNNHPDPDKKWGTASTPEELKETPVVYKDTEVVVSAWSAKLWSSFFFDWRSRPLHNVATTTGFAGGVSKVHKKLVKRAKKHHYATLKPLIVLSSRGDDVLQSNETLTFVDGVGPARVEIELGYNSHDVFLSSEVDGVGMAVNFIKSWMDAKGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ48</accession>
    <name>A0AAD2CJ48_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1931012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ48"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="500" mass="56517" checksum="7220F5279859CEE8" modified="2024-05-29" version="1">MVASASASIFNLENNVISTTFGFDHQEGPNDADNNANESQPVILIDHNDFNQNISVEKIDTLVDGNSIPASITTLSSCRIMIYSKTFDGHYEVFESIARKYPLPFSSTTKCQNAGLTPGNPIVVDFVMPFQWQGGYKDEDSNNVAAKKQKKGKKNTSGGKKKSFQQSEGWGWTAYYKQHLQNSTAQRILRNENDDVRYIYYADVLGLDKRSFQSISWKSYSFVIEASCDMWGNQFWKDWLAKDKKRHFCVFHRKHEKTNLAKSTEKRTCYLNPQFERDHHCWFLPSVYPKFPKPTAPFTEANPKLNICIGWKSMGKGTHYLRDESLLVQALTNMQTSSSNNDQGDIRERLQVLVIGRNARVPEAFVQAKMATMVQVHNNMVAFYDYQQLIATKCHALIPLVHPEQTAYFLTLPKMSPGDDSGSKTKHNGQGRLSGMIAQVIGNHIPSLIHAAVADIYQHELTAPYFVYNSTKDGGKAFQFAFEGLIDYYSNRSLGHGMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKL5</accession>
    <name>A0AAD2CKL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000481">
        <property type="protein sequence ID" value="CAJ1935560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="397" mass="44745" checksum="D4CB3663C4C18BCD" modified="2024-05-29" version="1" fragment="single">MRLDKTIHQSFGHPVTDTTKPGYQVTCPEDFEPEDQRMEELEQLFDQWNDPTLTFAQRMRNGETMSPGFALLVRKGEDGQPCHIMFISNPVLTKPDVMEPNTFGAPAPFGEIVNNDIAQNNVCLSCGICPASDGFEAFHESITNRKKIFTGLLHLLTSRKTIIENWFNAVKASPASFAVPVVDALPFWSCFPTEHDPVDARVLDVALLAPFQEQMDRFLRSHLMQLIYRSGSLPTSTLGFKMRAWVRMHNMRLAESYPTALGITLPPECQAFVNYLFPFEDEDKGWDGRIPKWYKTLDLDSGTEVPDSYLQYTPRPLPSSAQDPDDYVTQRLTVPPVAPPAALQPMDDDLAEFLQATKRHKPNSRRSPVHPPVTPAPEDSFVLTEEGNFEDGHGTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL62</accession>
    <name>A0AAD2CL62_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000272">
        <property type="protein sequence ID" value="CAJ1933460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="222" mass="25691" checksum="5F2487D6208CE5A6" modified="2024-05-29" version="1">MTKVGSNVEKFNLHVSEQLENLAHYGEESKDVLIHLFEGYKAASDKSFVSYIERKEEKHEDNSEPTNEPRLMQDAENYYKNRVWDQTWNRPDENQQAILSLKAEFKQIKNSKKPESGKKKDNDKKSGGGKNRGKGKNNNRQKSSNVPAWKTTAPKAEDKLKAKYVDGDSKPWYWCEALKKYCRHTPDQCNQDQNKDNKKNKIKLRAAMAENYAPSDSDTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLM4</accession>
    <name>A0AAD2CLM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000746">
        <property type="protein sequence ID" value="CAJ1938650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="188" mass="20824" checksum="5572F060BCABD78D" modified="2024-05-29" version="1">MEQFLRQAVVLQDLYGVAWFQNFAIKIKRYAAVASTDTATIDKFKDDIFEAVLCNCDQMRTAPLMLDLQTNYCREVDYYPKTVSIAQDMLKIHMDVIKNPGVNLCIKEKTNLIKIQWKNPDQYIDYGKKLNLNQIGATIPATVPAIVPGTSASTSGASSVAGTVNTPLRLAGTTGNQMMQVPAEMQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLY9</accession>
    <name>A0AAD2CLY9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLY9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1926349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="192" mass="21553" checksum="20AB5AE5A2AFDAE5" modified="2024-05-29" version="1">MTTVSKKGVTFSSNVTGIQIMNIEDYTPSEISASWYNQEDMDRITDRCLKLLRRMESDISNRGKKYCTRGLEGHTALASISKNQNRACARAAVLMEQSKQWIENKVDDQAIADAYSSTTSSCQLWAQVVGKRDEDIAEDIYFMNENEDCLNATVATFSFKSKDSGVPGFEQRRMEQAERPSGLHRTSLALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM53</accession>
    <name>A0AAD2CM53_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM53"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="447"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="534" mass="60550" checksum="39C722877ABD54B6" modified="2024-05-29" version="1">MPPFPHYNLHNPSMLSCLPSPSPPNLPQAGATNFQTTKDASSNEMKQMEDFLASEFNQLSVEEQTKALNDIYGVGEELKESHDLTQRSLAEFEKQLQLGKFPIYETAVSRNRAYVEDATFRLKFLRANMYNVNRSVNQMVNFLGHKATYFGVDKIARDITLEDLNREDMDLMLSGFYHIQDGTDQNGRVIVYMFNHMLGKCKAETLIRVNYYIWFNILAPLPAVQKKGLVAVYWDLTKPEETIVLPELHWMLAVFDYIQCVPVRCSASHICAKTGSGSAMLNNFVLGLALKAMPEYARVRSRLHRGRDLELIAQLQRHGFPNTFPVDSHGNLRRGILNVWFHLHMANEASCAETFNRFVVLEEGEEESTSTITMDSSDEEEEEDMVVMDAGTYTVGPAWGYIGNILLSGSSLSGSSTSRTDSARSSEDGSAAQANPQRISPDHSEKDVLLGRGRDIQNHVGNIRFREFLTAHQDEYDDAPRNQRRQIATNLYNLLKADGIRFWQKSSAGEWEEIGAIEGEKKIGQLFRTRRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM62</accession>
    <name>A0AAD2CM62_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="930" mass="102482" checksum="E8BFD1F966E03874" modified="2024-05-29" version="1">MTTSLHDSIASLDLASLNFNVADIAEVEFEVMKDQEKAETVSREDLMSSFSKFDSLVTPDDFSEGKEDDGSVDIVKKFLNHYEAAHHDITADLRAFQSSIGTLIPETKDKENRKTKKGPGKKRKESRKKSDERRYSVERRLEEADVSPVLPNDPPQVNTSSAALQDLPHAPPMGGKDDLTGMSICADMPLPVTPSASSFPERSGTLPDASTMSAKEILAELKGLDAKNMNFIEKSEMIAALKDARSSANCTTTNRTQKPPKPAQNRTVDGAPSTPRASRTRGRSTEPSPRSISASPIRAHLNNLMVVMDLEISDEKEPKTPRQRKKGLKKVRSKSAGTFDVGDSSPVKTSSSWWNLSSTEETSKSSKESKSSRRKKGMRKARSSNALGDDDNILAARLKLSKSSANDTWDLTQTPGRRRRKGLKKSNSNPLLDIDALPLSGAFITSKSNKANSALEETPKTRNRSKLKGRSKSNDSPLDVDNLQPRLQKKNIHSWWNMMVGDESSKSSKESKSSRRKRGLRKAKSNNAIDDFIDYDDDDIAAAAAPKFNGNASWDLTQTPGRRRKKGLKKSNSNPLLDVEPPLPGAFVTSPSKANDSFGLGGDEIGTKKKKKKKRSMSLRRSSSNPTLGVYDVDGNDDGSSKRSKESAGRKKGLRKSSSGSKLDIDAILADGGGLSKKNKRSMSLRRSASNPTLGIHLHSSEEDGSSKRSKDSGGRKKKGMRKNRRADMRKSRSNPTIDVDIPREIFADVIAAPKANFSWDDLRGGVKGKNQRQQQQQMQKQKQKKQPYKEKQTVLYTSTNGEKEEAVIVKVYLDDLLVPFYDIKLSKCGKEKQTDDNHLSAIKSTTINNTRRTMRSQSVDAATARRSKSMDVATAARGRRVDASPVSVRRRLKKQAPGAPNIHKSPVSMRQKLSSAQSPGSLRKVYRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMU9</accession>
    <name>A0AAD2CMU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS6879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF64">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042195117" description="Phospholipid/glycerol acyltransferase domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="8">
        <location>
            <begin position="152"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1940116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="349" mass="37995" checksum="B8095F4F8DB02823" modified="2024-05-29" version="1">MKPFVCRAILLSMAVSSTSGFSTTTKSSLSGSIPSSSILRAANPIEQGELDTRSFQLSQDEINPLLTFGEPPKEKFVNAHGAWCFLVSLVTGPIWLLAMAIVGKKGDNDVNKAEYDNTGKIWSKAWLTATNSYPTISGNVERLEAGNDAGACLFVANHASWLDIPVLCTVLDPVFKFIAKGELAKVPCIGQQLTGGNHILIDREDRRSQLKTFKEGIKWLKKGVPLMAFPEGQRSQDGHLMDFKGGLFLMAAKTNVPIVPITLSHTHAIMPSNALFPFQAGAGKLHVHVHDPIDAKGKTEDELSAAVREAFIKTLPLEQQPLETLVLEERVEEAEVEVEKKPAEEKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN22</accession>
    <name>A0AAD2CN22_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="110" mass="12886" checksum="63644C23F8CF3EEB" modified="2024-05-29" version="1">MSQTTTTDTPEQQQQEDFASIPLGLYWDEWSRCIGSRYQRDQLYRLGQLDSCSRPWKDMKKAMKAKVLEISEPDKAKELMDSTYYKKRTTISPTAGAIWELKKKPSWTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNL4</accession>
    <name>A0AAD2CNL4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042078689" evidence="2">
        <location>
            <begin position="26"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="723" mass="77824" checksum="A5ADDA477DB38906" modified="2024-05-29" version="1">MVNSYRKIAISLFAVVASSISTSASEEVEPTWQVQIGNAREIMDPNNHHFHNHLRSLESSNSNAASRKSRQLNGAGTVAAPPIMVPPVSMIPPNTDPNTLTSFFELELVTNGQKPKEADLAQALDLFVSSYNELKSTFNDPLERTMVSTQLEFVDNVGDARRRRRTTTTTTTTTTQDERQLQNLNVLLFLRVSGTCRGCQSNPFFTNQVVGRRQRGRQLFANPINSMRSGVPTEAETLSAYSRSLQSASTRSIVDVVFLDEVEARRSTGKGSKKSSGKSGGGKGGSMSSGKSSGKSSGKGGAHPPTTTATTTTTTMPAGGKGGTKKSTKKSGKGKGSIDTITTRNTLTSFFELELQTSNGSPTDNDIQNAVDTLVETYNSLIEDSFVDPLERQMTSAVVVNGGGRRRRTRKLQNLNILLFLRVSGSCRGCSSNSFFTNQVIGRRRQLFDKNISNDLKEGVPTEEEVLDMYSSRIASGNFGSIVNAVRLDEVEALPNSGKGSKKSSGKGTSSTRVNSSNNNNNNNPSMTAREAPLMEVSLSAVTATVSYPVVQLKMTAQEDKCMSYTPGSDIIKVETCSSGDDTTNGNDHWEVITMESSGSSFKLRNKIAQLCLPQNPDAPGSPFDCFASSGMGEAIAGRISGLVDCDSSNVATLGFLDFFNPTGLYLQECASGFHPGKDNDIILVSYVEGEDVVVAWGEKIMLDLEGVVTSHGMQGSWSMKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNQ6</accession>
    <name>A0AAD2CNQ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000962">
        <property type="protein sequence ID" value="CAJ1940821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNQ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="227" mass="26778" checksum="5F0CE01E4A6C7B1A" modified="2024-05-29" version="1">MTITDFTVRKKSYRYLTTQASYPNHDSKAVLDAFDPTKDLQLQDLTVLGPKYLTANQQARFNSIHRQAYEIHQRAERNCRKLLMGKVHWSPQMQQKWDRLHLYHLLILGHKQVRTSSRKAPRLLKKTGLSDAWKLLESALQAKWHLEYQAYKEVKRKRVQQWRLEYLENRSAAVQKAKKSNIKARTRRTQVQRMAQKEETRRRRKAQGKGFSGGLQQIKVAQDGTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPN1</accession>
    <name>A0AAD2CPN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37109" checksum="178356FF991FB352" modified="2024-05-29" version="1">MQLKAIYFITLLAPNIQHVVSFLPQQHVPSDTTVQHHQEQRHQQQHPSVSTNLSQQAARSIPRGGSALNMSPSSMVSTIVSSMQTGPWGILALSAVTWSVVLPLTLYKKIYGIGVAYGFSVAAAGLTMLKVLSTSTSSQSSLLLAKACMFYGARLGSYLLLRDYLRNSKTTIKNGSISSRITFSASLALFYALLTTPVLYALRSTNGAVDSSISMAGASLAWTGAILEAIADLHKLIVKQSSSEKDGKKFTGPDTWTYRICRHPNYLGEMIFWTGLFLGGAGSFGKSIPAWLGSSFGLAGILSIMFKAASGLEGKQTEKYEGQERYDTWKGKAKYSLIPFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ98</accession>
    <name>A0AAD2CQ98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS8013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="62"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1942570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="64359" checksum="A47B03FF33411ACD" modified="2024-05-29" version="1">MNNHGIRVCDSCGLPPRDNKKLRSCSRCKSTWYHDLECQKRHYPTHKKTCRSPVLVSKPKEPKPQSSKFVTENRTGRGNCLVASSLIEKGERIHVNTRSNESWEPLVLPVLRSDNRRTRCAYCFKSLDNSNFFRYDQVQPRQQYFLLFCSSHCRNAGRDKFLLQEEERAIGRLYNNAQHGGPPKILPTAVLVYRLIVATQFHRSKRKLIESEIDKLQHEFADTTIDTKLTNSDHHTQAVITTVVAMIQESSSNDDYNLALPAIEEMKRMVNRIKLNGFSICDGESVAMGIGLFGTPSFMNHSCKPNAVQTFVYGRQGEPPSLLVTAFENITNGEEICISYIDNLAPKQIRRHRLKQDYFFDCCCIACEDQLYNTGIIGLKCGNCDATSPKMIMETSQAPGQQILKCQECDDKDPHDGFPILETMELVSTIDNMMKFYNKLKQSYSSESWYVQNCGDQLVQMLLDLLGSQADDDQQQRSTTSRVLKLLNELNTSHEPKAAHIVWSGSFRHFIRQYKAAKLGLFLHSDPREAISELQRVRKSLSPYFTEDHELIQGIDDCMRSGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR41</accession>
    <name>A0AAD2CR41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="560" mass="59631" checksum="11E96598921DA67D" modified="2024-05-29" version="1">MDKHEERDEKRRHRLSLLGIQSDRSDDSSDDGRTDPINNQNVATSASLPPASQASTSQRMEKQASRPSMFSMRSPFLVGGELKSRVSNVARMPSRRSIMSDVESGGILREKQPPPSPRPRNSVVGSLQRNESQMTIPGAFRVHANGIIDDDPTVSSLNTKETGPFVIDHASLIENPDLRAHLASGGAIPTDHPLTNGATGGPAPDHGAYPMPSYSLNRNRTPTAMPSLTSSAPIGIGEPVSTRRNQDGFSMNRRQIRLMFLMLAVAVGALITGVAVAIDGRSEPEELPVNSAVETSPSNEQPLDWNDDGISLGFSNDSKDVMDKYINEDVFPTLSPTVLIKDSRASVPTAAPSAAITSKPTIEESSSPSQSPSTPYPTPLPTTPNPTEPLATPEPSSTPTGQRPSSSPSNSFPSLSPTLISSSTPSISTTTGMPTTRISSKWPSQVPTQSPSQFPSTVVTTVKLTTSSPTIAPSETIFEMERTTGQNVTNMTESDNGDIGENSTNTTGSDNGDAADHQNSTSTTGEGDATMNEHNVTQDYWRDQVSVATAGDVTPINWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR63</accession>
    <name>A0AAD2CR63_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="255" mass="28505" checksum="1B467B68E1097391" modified="2024-05-29" version="1">MLFEVATVVLCKIENVHLFQYGGKGGKWREYGSGPLRYKIILRSDPRFDSQRGKGQVTFHNSLTCAGGLNMLVIYNFPLVHKTTSKPNEVHFKARSAVIGTDYKSSIYGIRFASPEDAARFMWAHWVLQLASINPSIPSPLSVEATTTRAFMGMGQEEHEEQDVINRHLIISSLCQLASANRAVLSSEHPSFQWAEQRLFDADVNAGRLLHNATEVDAEAELDAEAKLDAEADDDSASVHNWESQDYFSLDSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR75</accession>
    <name>A0AAD2CR75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calmodulin-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33213" checksum="5B0B7D42E170175A" modified="2024-05-29" version="1">MIQPPSPEAYSNLPPKRTLELVGTKEAGKSSSAGENRVELVEEDWSEIMISHLSGGFAQHKKEEFQLSNGSIVHIASAPSLTPMDMVDLSWGRNDATGHCIWTGARFFLDILIPALGQLFIDRSILELGSGTGLVGIAIAKLFQLKELILTDASESALELCRYNCALNEGSIIIGVEELTWGESLLTCNDEQSSTLRTFDTVLATDVLYDIAAWEPLLVTASKSLNANNGVFLVSHVPRAALPDGCVAESLESHLIQVASQHHFRLVHTYQPSNFSTILDDWESLQERGVAIFEFQKMTVIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTE7</accession>
    <name>A0AAD2CTE7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001369">
        <property type="protein sequence ID" value="CAJ1945346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="473" mass="52585" checksum="CCFC0FD290B5B297" modified="2024-05-29" version="1">MGFITVISRLGSILLQWSNAPLQYGDIVKVGCFAFIPPEVNFKAYAKEIICHFDFSIPIGIKMDWVSTPYTGRAKFNKRSPSVTSPHGYACKIHAKRVDRELRSLLNPSTAKPDFPFAAPATFVSDWKSAQQGLISVKAYGPVKDATLTLISKLPQADKASHAHQSTTEADESVNDSSDDDPNESSGYKGGQFTEVWSKKAATKVKKKAKKKKKLITDNENPFLMDLSPAQQKMAEVADCKLKNDQVRHKSGPLFLIILPGKMEGTYILVCRKKFGQLARNVLKRLLPFLTHHLYEPTLTKTDQALRKWVPQSEISMAQRKNLKWCTNTLCAVEATALPDAVEEALEFLDDVMEDATDVYNGQLLIDLDMANNKDIDDGKTVTGMMDKMQEREQQLEDAFNEIEVRDNALEAQERALAQQRADNAALQAQLAALQSQASHLPTMMSQPSPTLPHNNCVSPDHQALTPPVRSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTR5</accession>
    <name>A0AAD2CTR5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001469">
        <property type="protein sequence ID" value="CAJ1945723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="141" mass="15096" checksum="37C5951358919964" modified="2024-05-29" version="1">MSPKCPDRLLPKTQWKNQDQYVDYGKKLNLNQIGATVLATVPAIVPGASASTSGASSVAGSVNTPLRLAGTTGNQMMQVPSGMQLMQIPTQGGGTVTRCPKVLHSTQNPCRSRIKFCEQGIFQGKIVELTFVIESSIQAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV38</accession>
    <name>A0AAD2CV38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS10329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001646">
        <property type="protein sequence ID" value="CAJ1946188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAZ-type" evidence="10">
        <location>
            <begin position="320"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="602"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="411"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1946188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="79488" checksum="B91C4D95654F79F3" modified="2024-05-29" version="1">MQTSQTAPQVPAPQAPSPRTTQLATTSSSSAVLQPPQMLPAPVPTATTVHHTQYAPAQQQQQPKQPQHCSQQSQHPPVAMPEQATRQHVPTSQPPEQQNLHQVLNGGWQSDQDYNERRKMIANIVQLLKQRKPNAPSDWLKKLPQMAKRLEESLYRSAKSFAEYNDGSTLKQRLQQLAHNIGMKTKRMQQIAAKQKQQQAHLAAQNKAQYRPPPQHQSRSQPIVQQPIAPHQQQPVQPRPSTSLQMQQPPPVQKQGGQRLVNVSEINPIMNSGNQVVQGSSAPPVPRVQHGPIAYQTGSQTPIPSAPPPATGSRSAPKQVSDRQQVLRHQQQRLLLLRHAAKCQHEDGRCPVTPHCAGMKRLWKHIAECKDQKCLVPHCVSSRYVLSHYHRCKDVRCPVCGPVREAIHRSHEKQKQMQALKQRHQQAVQQNQSVAPQGQPGLPPTSLQIPPVVPAASPGEPIAKRQRTAPPGPIPQYLPSKSNPLSAPTSASRLPHQGLLAPPPSHHGVLPQPKAGYSIGQAPTAPTNVLKKLSSLAPGVAYSNGQMITPKYTGPKPQEDHTLINCFTISQIEIHIASLNKGLQLAPQKIKAKCLDVLKVLQSHQHGWVFNSPVDPVELGLPDYFEVIKTPMDLGTIRKKLENNCYESLDDFKKHVNLTFENAMLYNPEGSVVYNMAKEMKIKFESDFTILMKQLNAEXXXXVRIKQNVLYRECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV75</accession>
    <name>A0AAD2CV75_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000666">
        <property type="protein sequence ID" value="CAJ1937551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="174" mass="19414" checksum="12BC29DB92FEB341" modified="2024-05-29" version="1">MKRRIDGTRRLVSSSNRGLSLGDSSRVTRTAGCKRPLRCWGNQQIRWSTSSAPPVVPEISPSVIARQRQSRTIAALISVVFVTAVLIEGNAKQGWIGKDPRPCHGYIRNPHGADGQLEEQVIRIFAKELKDALTYLGPAWIQAISNEKMGHYHGGNQRFAFPKLRLEFNISPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CW11</accession>
    <name>A0AAD2CW11_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS6217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000746">
        <property type="protein sequence ID" value="CAJ1938644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CW11"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="339"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1938644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="520" mass="60207" checksum="A9BE2B3F61E43EC3" modified="2024-05-29" version="1">MKWMIDASFAVHPDFKSHTGGTLSFGGGAAQVMSKKQKLNSRSSTKAELIAVDDVVTMILWTKLFMEWQGYPIEKNILYQDNKSAILLEENGGKSAGKRSQAINIRYFFIRDQVEKGNVKIKYCPTDNMIADFMTKPLQGVCWDMTKYEFLRSKKKLFKYKVFDMYDRTLITMILWTKLFMEWQGYPIKKNILYQDNKIAILLEENGRKSTGKRGRAINIRYFFITDQVEKGNVKIKYCLTDDMIADFMTKPLQGEKFCKFRDLILDPQDQVRQKLFKYEVLNAILLEENGCKRAGKRSQAINIRYYFITDQVEKGKVKIKYCPTDNMIADFMTKPLQDVFKYQTGAVITQDSKPIAFYSRKLQDGQHNYTTTEHELLAIVETLKEFRTIPLGHKIKVYTDHKNLTFTQFNTEHVLRWGMVLEEYGPEHIYIKGPDNVVADALSRLVLIDEEDEDSSPSSPTLKIMAHNDGKRSSKLSIPKTKNAFKADDVILNDYMNICRDKLPDNIYPLSMSLISAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZG8</accession>
    <name>A0AAD2CZG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10635</name>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15779</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001702">
        <property type="protein sequence ID" value="CAJ1946493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001891">
        <property type="protein sequence ID" value="CAJ1955496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF31">
        <property type="entry name" value="OS01G0873500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1955496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="521" mass="59293" checksum="6DEB03D64A77FF5B" modified="2024-05-29" version="1">MSEYKERTPRFQFSGEPEDYNTFGLKYVARASVKRFDGVITGEVTLRTKPEMDAETDAAKIKEDEEISEMNIKAFSDSMISMNTDTAEGKVAFNLVAGSRDKVNYPKGNAKEAWDKLKDEYEPKTITSYIKMKSKLNKCHLEKFANPASWITELSKICVRLEEMKHPVSEEDQFIHIIGSLPLKYRQEQKDFEKMMKANTLTIKYIKEELNSAHEDFANATEGDDDDEDKEDKDVALVTGQFKGNCNNCGKYGHKKLTCPELTQATRQGGERKQNNGGRHRYNGGGRGAFLGTCFHCGIRGHKKHECRRNPENRNNGTTGNNGNNNNSNNNDDDDDDVAEVMLMATETLIAPAEPTQKKNFWFEWNEECEESDCEDEEVDDEVIVHTIVEDPNDKVHEHGNFLHDDFFDNFMANFGQNDCDAKNDETFHATKPTSEYAFVTEEIEIKRYSDVDGSGTYDSDGDEIPQLVERTMKAKHYASDEWDHNNGMHEYNSDSDDSDDDDIPPPLVSRHGIVHGHDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZH1</accession>
    <name>A0AAD2CZH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001158">
        <property type="protein sequence ID" value="CAJ1943904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26453" checksum="BB567A4C5F7520C6" modified="2024-05-29" version="1">MRTIQLMNLEAQANNKKAGRAAMRYAKEHSLIPDGQCGSRKRHQAIDLALSKRLVWDLLILQRCAAGWISNDAKSCFDCIVHWVAIIAMLRFGLTWRALSSMFNMLSSATHWVRTGFGDSEHTFKPPSVIPFQGCGQGNGAGPPIWISVSSVLITMMEAMGYGFECLSALESQLVTAQCFCFVDNTNVIEAGNTVHHSGEAICASVQDAINPEKSFWWLIDFEWDSRTHRKRKSVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FAS9</accession>
    <name>A0AAD2FAS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bulb-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS346</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 99 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1902192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FAS9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572">
        <property type="entry name" value="ENDO-ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572:SF4">
        <property type="entry name" value="RE57134P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16317">
        <property type="entry name" value="Glyco_hydro_99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="11">
        <location>
            <begin position="322"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="281"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1902192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="719" mass="79958" checksum="04D5C3501DD9578F" modified="2024-05-29" version="1">MARRTRRSNSPRSSTERSSDEEVVEVTTASSMSSKKRRSRRSSRYSTKKDSTGPSPLDEEARNEGVRASQTKSKKHRSSRSSRHLTENGSSDVEENEVVKASHRSSKRRSSRRSSRYSAEPASDEEENERAIHRISKIAHSHRSSRVLVISPSDEDDNDLLTTTSSKKTRRSRRSSVETRRDNCRLMIGAGICTLGIFVAVVAVILILQRQNTTPDEGLIAQEEPPTAAPQYSVPSTKEPTASPTSERTTSPAPSTTFSPSDSPSFYPSVNPSVLPSIVPSAAPSVNPSESPTITPTSEPSPAPTTTFRPTSSPTPPLYPRTIVLQSRQFLQRGEFVSSPSRDYRVGLSTTGEFVLLDSDGNEIWRPDAMDAIGAEDLYLQADGNLVMRDASGDSMWSTKTSTSSASLFVLDDGGIIGLIQTFRTSTESTFVWMKGVPRGTYNGQPDGSAISYPIRGAFYYPWFPETWTVGGKRAKFAPDVGWYHSGDPTVVRKHIEQLEYGRIDLGVAAWFGIDTNNDIGRITQILELTEASNSPLKWALYYEMFEKVRTVEEIRSDLEYIKKWYCWHPSYAHIAGKPVIFIYQSRGCDIIQNWVEASQGEWYLVPKIFIGYGGCDAQLNPGKYHQYAPAQAVEQYDGLAFTISPGFWKADEDEPRLARLDKSTWCQNVQSMVDSNAPWQLVTTFNEAGEGTIIEPSRANWPSASGYGIYLDCLHDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBF9</accession>
    <name>A0AAD2FBF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1922819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053943">
        <property type="entry name" value="RlmKL-like_Mtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF13">
        <property type="entry name" value="TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="99"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1922819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="675" mass="76167" checksum="B6D4B2F7BD9273D4" modified="2024-05-29" version="1">MVNPDFLIPLETPCVFYDEDFLPKGDADGYYAKLLKEIKWEKSAKINRWVSLHHNLTGEEDYKYRDAPGAAQQGFHETVDHIRKLAEDWYEKEAGRRVEFNVCLLNYYENGQQRIGWHSDREEVGRSTPIASISLGTPRHFLIRSKVNGVQDRASLDLANGSLVIMENACQMEYLHSVPKQTEIETGRINLTFRCKEEGDLTLGEEAHELRDNCIMNLTDGMAADASGWSPVSDATKSVFGDNVRSTELDPDYPEIYFLVSTNLGAERYCAAEMTEVLDSAGLLMDMWSIVAAPMGLDGLVACSSKEKEPDTDLIRQITSLFLNLRSAQHVLNYHSHFGLEEIGEDPAKVDGETLYQYYKKQLVEGKMSVPPLEKLGKGTFRVTCERIGGPHAFQSSQVQFEMGGAMVEYYSKIKPKMEDYDVCVYVFVIGYQVVVATQLNVNDLSKERHFLQFRNAVTIKTNLAYAMVRLADITAGDRIADPFCGSGTLILEALEVYHKKLFCVGMDVSRRSANGAKQNAVAENCGDDVCKFVCCDARGLRKHLEDDSVDAIISNLPWGIMTGHKDVSDLKTMYEIFLRTAWYVLKPGGRIVMLVLRGLQITRIVRKLSGRFRLLSVNVVRTTNNLPCIVVVEKLKEDEIRDSIKGQLAHFNQYINVSPEIYHAIHNEDIDEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCB1</accession>
    <name>A0AAD2FCB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1995 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1909458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041911094" description="DUF1995 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1909458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30761" checksum="738D115B772E276A" modified="2024-05-29" version="1">MTRTSAFLFLIQLFGLALSFSNERLQPRRYDTSVSLFGGGGGVSKLPSPNGRDKQAIDSIKAAISKPRNPSFPLVECEFPPLEALNKLGDGSQRSADQVDSANFAFAAKLVKSLSGIPFLGPNVYLFLSAASSSRTISKAKSIIKGATYVGSLKDRIPDTFKTGDVVVVVAPCIGPDYSIASQLAKDGIASGVVIINGLAKSAKSVSGSATMAYYLKPLTYNSQVVGYLCRNYPNDWATVDLLSKQVLKSYKDEEILFGDSNAPDLRGPGFLVQKCVDERAIQSRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE20</accession>
    <name>A0AAD2FE20_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000166">
        <property type="protein sequence ID" value="CAJ1931612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="114" mass="13257" checksum="9BEF7C35713BD67C" modified="2024-05-29" version="1">MKADYEEHNAILIACCMMKIKAKFDTEEGLNFIQQYYINQGLKKFGDDGKDAVDKELRQMLLRDCFTPKFVRDMTASEQKKTRSAMMLLAEKQFEKTIIGCLVYQGVGTREWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEB8</accession>
    <name>A0AAD2FEB8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="11">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS2751</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Peptidyl-prolyl cis/trans isomerase (PPIase) that acts as a key virulence factor by promoting host leukocyte transformation. Binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins. Promotes host leukocyte transformation by binding to phosphorylated host FBXW7, disrupting dimerization and promoting FBXW7 autoubiquitination and subsequent degradation. Degradation of host FBXW7, leads to stabilization of JUN, which promotes cell transformation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with host FBXW7; leading to FBXW7 autoubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="CAKOGP040000214">
        <property type="protein sequence ID" value="CAJ1932234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEB8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="4" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="14">
        <location>
            <begin position="132"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="66"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1932234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="251" mass="27521" checksum="ED16EB9B68B29C15" modified="2024-05-29" version="1">MAEAIDASAVADAIANVVGPSAAFLGDPPPPLPQGWVLKESRSNPGCCYYYNILMGISSWQPPVLDEAKEEQVDSGAMQKQLTTQPQDVPKSYSSITESKALPPGDLPKDPEVSEDRSSKRHKPQTSSSSGPKEVRVLHILKKHKGSRRPSSWRQPKITSTKEEATEELLGLLEIITEEESNPEELRATFEEIARTESDCSSAKRGGDLGFFGRRKMQPAFEQASFDLKVGELTKEVVETSSGFHLILRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGD2</accession>
    <name>A0AAD2FGD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGD2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041934208" description="VWFD domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53435" checksum="67C191489E7B5B18" modified="2024-05-29" version="1">MKFISTLLFASLAILSANANNLPATDLGLGCLNFQDDGSWNPVPDFVTNGPFLVAPESPFRFSSDTRFPDQAVRVGATGKLSASDFDWTFDIFNTQAQNGGTYEAWYKSNNHGTFATTWHSTSANGNKHNTFQIVISEAIGGDMGEGNNVCFCYGDMQWGPGDVRVHSSNSSDHAHIDFSGGTYNNAAADNSLDHKTCCFHADKLKELGSSADFARLCHVRGTEAGSNGDPHFKTWQNEHFEYHGQCDLVLTKDTHFSNGLGIDVHIRTKLVRHWSYIKNAVIRIGNDILEIEGSALDFDSKTHYWINYEYQGELVEFAGFPVTTFSQQGTAVTKNRIEIDLDSAYPGQKIVLSTYKEFVKVSFENASEESFGKSAGMLGEFKTGKTLARDGVTVLDDFTELGNEWQVLPSDKHLFHEMSAPQFPDRCIDPEDPRGDRRRLGGSFVSEEEAEAACTGLKDELDRKDCVYDILATQDLEMAGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGI3</accession>
    <name>A0AAD2FGI3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000582">
        <property type="protein sequence ID" value="CAJ1936970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGI3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="43115" checksum="F8EBAF407E5BCD39" modified="2024-05-29" version="1">MPTSDDQVCKASDASRSRFSRDLVVVAAYRPNPLGTGESTVWAQHRSFFRSQGRQREPRETFMVDLLRAITQWRDEGCEVILGVDANEDIISTKSSSFRQRLRDVGMEEAILQRHPGRTAATQHRNKRGKPIDGIFTTSGVTVQAGGYYNFDEFFSCNHRGLWIDIDLEKSLGGYKPQKTPYKPRKLTMLDTTAVRRYLQLVHKGYEEYSIPSRLASLHHQLQLNEGTMTATMGRHYNCLHHQMYVVRRKAEEKCRRVTNGSVPWSPKMQQFWDRQSLWKILLKGRKGCRVSSRKIRRLMKKVEIPDAWTKTTTELEAALRQDRKDYLEAKTHYAAKWRKNFLTVQAAKSKKKQWRSRKARVDYLTPETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGY3</accession>
    <name>A0AAD2FGY3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS5677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000657">
        <property type="protein sequence ID" value="CAJ1937486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="612"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1937486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1433" mass="158211" checksum="27C125F061290007" modified="2024-05-29" version="1">MTASSAASTPKYNQTPEKALEEKILKQVLAKIQEFKDDTDSKIRMSITSRGSNALVPWTCLQTNNHAANNASIPAADDPSNFKLPKDVNSILATSSWCSVPFWISMFVIFGFQYLLLLLLLANQVDINSDDNPLNLPANVETPVRISQVLLLAIALFSQDDLLVGIESFFDGMPDYFRGNIRSVNMTLVQWRLSSIIRLFQGLLNLLAAFVLSIQAETIPDVLLNVLGVGFISNLDELAFSLAMKGYFGQSMKMSTEDVSVVEFYRDATRTQNTKSSLLAKLKDNVHIIMVFAVLLAMLVAFSIFSSQQNAGMYSEQDIQIEFGDEILPFLGLFNGCYKASKSNKHASGRLMYEQVSFSKGGKFGFCSDFGEGNGGWAFFIGESGDVCDNHIVRSGDTSTFSLLEAATTKWYTSDDLPLDYLEITEIKTASAECGQSMLRTTTDACPSILAFDSLTMSKMALNKDDLESRPVLDASVSHPIYYYNVSEVGIFDFLFFTGRRWIRTQSDHIATLGNETSLPDIRDFFVVNDGLFTLINELRTSSDDRSEWVTAVSEIVDSKRDQGSPLGLQWYVPRYDTTDDANEEGDSRGYLQRNFPSADLARPIDSVMTCLHCNEESNPCRYEGFCDNGSGICACQHGAEGKLCQIRPLGNGVCNVYFNSAEHQYDGGDCCAGTCFGAQCGEDDLPNPFLDASVLTIRQGFSGVETVYTFQNVTEDWKNTYRGTEFGFGVDINDDELSFDFAPLRYKHCIDPNTALLSIKIEPYQDRWDGHRHSQFQGILVRCGGKMYLRMPEFSLNAIDDSGTFIERVRIPYGADCEIEFPNERTPYFTAVSILMENESVPFIQQQHILGSYPEPINVRIPESSCVWNGFVANRFSVSSFTEATYYNMPDTSLGWNEYMSGDDYDSFAEGGQLDAICERDQDEVFDRYVLWKISNSTFMDLSQNFISHVCDGLWKEDVMSVACRGRRVSELAVDIDVIIQSEVEGVIKLLMYVNELEHVGLIAIRNETHKSTALDMLSTLPLLTSLDMSDGVLSSIPSQITKLKSLTKLNLNENRLTSLSAIGSLTSLEDLNLNGNGLMSLPSEIGSLTSLTNLDLHYNDFPTLPSEIGSLTLITNLNVGETLLMSLPTEIGRLTSLTRLELHESRLTSLPSEIGFLTSLGLIGLDENGCSSLPSEIGNLASLTDLDMEWNGLVSLPSEIRGLTSLSRLNLRHNELTSLPSEFGRLTLLTDLNLYDNRLASLPTEIGSLTLISSLSLGLHQLASLPSEIGSLTSLSYLDLVENQLTSIPSEIGSLTLLRMLGLSENQLASVPSEIGSLALLTKLALESNQLTSLPSEIGSLALLTSLRLESNQLTSLPSEIGSLRLLTWLSLYDNELTSLVSLPSEIGNLTSLTKLDLRQNPIKSSMDSVPSEIQRLISFGLNVCIGDVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH42</accession>
    <name>A0AAD2FH42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000136">
        <property type="protein sequence ID" value="CAJ1931285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="16597" checksum="C99AB844117FDB2B" modified="2024-05-29" version="1">MSLQSYFENLQREHNATCVEFIADQAKCDEGRIRFPAAPSLAVQQQQPQRPSFRSDSERHSAAPTCPLRTTSFEDLVQLCHDEGAALALRMKNFALLNDKDDTSTTNNLVLVAQQSKNHEEHDELECRSSLKQLQPASSPANVVVARCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHA4</accession>
    <name>A0AAD2FHA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000713">
        <property type="protein sequence ID" value="CAJ1938373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="60013" checksum="5AC4D9E405897836" modified="2024-05-29" version="1" fragment="single">MRQVASKGYYSVVAHNENRARPIASCSQYGGCVATILNSVAHRAKSFGRDPTKLGRWAYVRVQGKQFARPTSDDQVCEASDASRSRFSRDLVVVSAYRPNPPGTGESTVWAQHRSFFRSQGRLREPREAFMVDLLRAITQWRDEGCEVILGVDANEDISSTKSSSFRQRLRDVGMEEAILQRYPGRTVATQHRNKRGTPIDGIFTTSGVAVQAGGYYNFDEFFSCDHRGLWIDIDLEKSLGGYKPQKTPYKPRKLTMLDTTAVRRYLQLVHKGYEEYSIPSRLASLHHQLQLNEGTMTATMGRHYNCLHHQMYVVRRKAEDKCRRVTNGLVPWSPKMQQFWDRQSLWKILLKGRKGCRVSSRKIRRLMKKVGIPDAWTKTTTELEAALCQDRKDYLEAKTHYAAKWRKDFLTVQAAKSKKKQWRSRKARDRFLRLRRMKQREEARRRRRAQGKGSTGGLHAIQVEERLPSGEVGLRTVSERSQVEQGCMQENCARYDQTRSPHMTPPMDAPLYQMFNGHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI41</accession>
    <name>A0AAD2FI41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000273">
        <property type="protein sequence ID" value="CAJ1933469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="114" mass="12569" checksum="737B3C99651EA317" modified="2024-05-29" version="1">MALTFFSPQEWDQILSPVLRAALPKAGICRNFPCAMVYAPIALQGVGVPHPYGLQVIKHLDMLLRHPANQTKTGAFLEAVLQAHQLETGTSYGLFQQVYSNTSILASDTWAKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK85</accession>
    <name>A0AAD2FK85_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK85"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="109" mass="12650" checksum="3AAA5C5CE70538A4" modified="2024-05-29" version="1">MAELMFGMGMTKKKKADNAYVKETKEALKNVNITETVETNELKNLHKRTQAEKEAERETKATLKNVNVTESVEGQVRKEQNKMEKDWKEAGRQQKKDNNNFDMARALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK93</accession>
    <name>A0AAD2FK93_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="650" mass="72584" checksum="A83E69C81E03D671" modified="2024-05-29" version="1">MPGGESTRRSRRTNLGQPPRRLGEEEETLEQDSNRTVRFRDENLEEIIDNRTAQVEMDQGQGAAPQQGADANAANQGNNQNVANNPAQAAGNNAGQAVTPQLRQVIATEIANAIGPLMQLLQGQQQQPPQQAQPQAQQQPPAPHQQQQPPAQQIQGQQQQPPQQAQPLAQQQPLAQQQPAQQQLPPLQNPPVPQPQPAAAAAVQQPQIVMASMSTFPQGTDPMIDPKDPVHGRLNRSMYNEAKEELKTKIDGKNLSMVISELRERCSAINCMDLFNVVTTNGTKNLLKHYGEITFQDTRQEASQRWMVANWHTQARYLIGMCLLRSMTEMFKLRMTQKRHLYNMPNDQPDGPLIFKVMCDVVRPSTRNTTQTLINRIQTMRPREFNNNIIQFNKKFTSLKEQIRAQQGGSNSLTEELLYNALVLAYDSVDQDQFKAFMGVKDNSAIQPHEDLMSEADAKFLDLGEKKVWNVPSQSQQIVSLTTLISKAEKKTIDVQQQLDKSKQSRKEKSKRKTSPVDEAADSGKRQRQTDFDRWMLTKPKKGEETKVVQKKGPNGQVKGWNWCNKHKKMVLAIGQDGRPHNSDTCALSKTQSNSNPKRAKKQLCVNALKAALALEDDSESDNAASNSDGTGEFPTNDDGSNESDSDNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLJ5</accession>
    <name>A0AAD2FLJ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS7467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042047187" description="Circumsporozoite protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="771"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="922"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="807"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="941"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="975"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1941329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1028" mass="108890" checksum="A29E9693627C7CCA" modified="2024-05-29" version="1">MIPLKHHLWLAGLALLIMVQLPSVTATDFNVYLLLQAMSQESSLLKSAFADSQSCFDNLISADSDSSYQLTRREYVQFMRSSGPPGFLMDVASFEDMPLALQSTFNALSCLCPDSSRTNCCNDLLDINGAGGDADQAEENELFLVCSLTRVAINYVANTEGPTAAPTFLEPSPAPTFVPSSAPTRQPSMAPSNSPTVSPSARPSSSPTVVPSARPSSSPTMVPSTSPTISPSVTPSLSPTITASNVPTATPSVLPTETASGVPTTEPSSTPSLAPSMPPEPTASAAPSGTASESPTGLPIIETSIEYRVGVQDGVYTPEFDSILVDAMDSLAPEILVATLGERRRVLRQRRRKLQSVALPTRIDEYLQDECDTLLPSEDGCAVIQASVLLQFPPGTTGSDEVATEFKNQLETAIRTGAFSDKLASQNPDTPLYIIDDPLLDSLSGDRGGILIEEDDDNGAIAGVAIAGTIVLAACLLFYIWHDRQQKDKEELEPLEPAPRDLSFLDTDDGVEIEKKDEAKDATPTKPLPKTPDRKKKKRPSQSLSPNRGDHDSDAGDSGWSSSAGVSSLNTGDQMTNEQLDTMDFSYEQAQVGSQMGGSSLGTPSQDDVSVPTTSSVTRADLDSAIESGDWAAVGATAALLAAASDSNSYSSRSLTNPGTSTRDGSSTVSSFDAAHVAELDHLVDAGDWEGVVLAAARFEASTVASDSESRMSGSLASSMTRKQQEYRAQVAGLLQRVAPEEADNIDEMILQFHGREDELIETLKLMEERKMAQETKDSPPSAADAKVGANARSLGTGTLTPKRKPAPAAASSLGPGSAQSLGTAKSLGTGVLEMTPREKKQSQLEKAIEAGDWEAVGEAAALLNDIGSASSADTDEINRLADGLSAGTGEFSTESGKKRSDKAEELDKLIDQGDWMGVVQAAADFESEDKKKSKSWFSRGEPKDKDSEREDRLKKLKAEQEALEQADMWMAIAEKSKDDSNKDDRGASEAADWAIGRSLAALVEAEGSPGKSPKKKTASGDTSEYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLU9</accession>
    <name>A0AAD2FLU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS8243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014:SF4">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="253"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1943032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="383" mass="43328" checksum="C1FF5A580C2ECC06" modified="2024-05-29" version="1">MSDSTQKIGGGAINEKQRKFQQEDGSIPETEHKTFNPASRSHLMHAIEGLDRYPAYLNRWSEDDILLLEESLENQLKKVRQQKEAIKGKRTNLKTVVENLCTKEPEWLEFLSPPKSWEELKTSILDEQIAAAIFRSRWFRRSQNQLPALSVQNVIDGSVKVEIDGGNLEPIMDEEMFDVYSFPLLAPSFCAKLRSYFSRVIQELEEDTDESLSRGFQDLDNLGLGWLNSLLLHLIVRPVSSHLYIETELNGGDLDWRQGYIAAYAADPTATKPRQRLVPHTDDSEVTLNIGIGEEFSGGLLNFWGLRGTSEAGKLVGQYQPEIGRAAIHSGRHFHEVTAITSGNRFAYILWARSWGGVRSSTCPCCWLNRRDDGSCISGPKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMP0</accession>
    <name>A0AAD2FMP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="252"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="529" mass="60775" checksum="5AC4EB8AFDB91074" modified="2024-05-29" version="1">MGRSVRKADFLSLDEMHPYGVLPGGNRFFGASNIRSEEVFADTIWQQILSFFDAKMLGSIVQSSHYFYVAGHQPELWRDLVLRQCFKEKKTIRAVRPSWRDTYLALFVKDSGKDHSPIPVSGVYSDEYYRTHLCRSFAIPSAWCNDSESSSPSSPNEVPRVAVEDISPEQFFEEYEMKNMPVIIEGAAKGMALNKWRKSDYLQQNVDESTTFRATSGAAPLPATFELKAYEEYGKFSYLEESPLYLFDRTAFASNNQWSNDFFPEFYEKCPFWDPAASHGHDLLQHLGAERRPDHTWMIMGPKRSGSVFHLDPNCTHAWNACIEGRKRWIFYPPGVNPPGIFPSEDGDEVALPLSVGEWLMQYWEEHTKQYRSRPPHERPMECTVGPGDVIFVPHGWWHSVINLDDRNIAITHNYVSPSNLGNVLKFFTAKQDQISGCRDRKESVKPEHLYDELVNALKEKEPKHLEKALEQKDWTCRTWKDEPAKSAETLDCNHISGKRKHEAITSTAEPKSVMAKTEKIEAFSFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMT5</accession>
    <name>A0AAD2FMT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS10681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001712">
        <property type="protein sequence ID" value="CAJ1946540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMT5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1946540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="62875" checksum="B51067C76F954236" modified="2024-05-29" version="1">MGALAGRHSGTVLPVASVVGKLIDAAGKARCAVANEVLHDTSPNQHESLLPPAQIRNAGNAVDDCPSDAKTTRGDFGTQCCVFGSGKEKHTLPLFFDGLKCYYRMEAITNDELTSLPRIVLTGDAEYEPTSRTTTRRMNTDKIDWKRTMAFPPDDVLKHTLEATTQLIPVVEAESREIMRDHLKSRLSCLRYHRRRDRDYLDTFKANVKSVRGFQYFNLFCGEKSGYDHPVLMQRKSESPETLDAHFEHCGTPHTLKSDNAKEFKSKHFKRKLRKAQVEAKYTEPKHPQQNLAELRGGRLKHVVQHILLLTGAPAEYWCYCLEYVAFVKARTSKRVLNNRTSWEAEFGAVPDISKCRFSFWQPVWFYTPHGAFPRQRMMKARFLGFSPDSGDAFTYVIVTEPDDEKAHRQIFTRSVIRPRYPREDAPIVFKQGKSLEIYKRDERTILTAVSDSDFPPALSDRAHNPLPTIQEEPQPLDSVEEYEQGIEEVHGPRLQNDFVTILRPTKFYCVLIKRSFSRSLPRTHQEVLPFRLLKLSYPPNCTPKIKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNA5</accession>
    <name>A0AAD2FNA5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="254" mass="28558" checksum="8DB6D25D3BF377A8" modified="2024-05-29" version="1">MVSSRNSQTSIESSALAKFLQTLNVGHSSVQIVVDNARPTALDRHIIGGGEQSRESQDSTATTKTRRPHGSNDASLGKKRRRRVSFNYKIRVVNCSALTNTDELFYTEKEYKKMKKEIKATLLRHMMEDESSSSNDDDTIDCMRGIETHLEDARAAKNRARLRACLAVLTEQKRQLLEDGNVIPMDGQELSRRYQQVSLECQWEAIQRGLKDWVDICPPSYKSTTQDQTPIGYEFGVAAPTICPKIRAISSFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ33</accession>
    <name>A0AAD2FQ33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS11976</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="351"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="435"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="519"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="561"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="645"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="687"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="729"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1949201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="92996" checksum="0961822895696BCB" modified="2024-05-29" version="1">MSEDNQKQSPCSMSEIGTISKIVKSANEQKDESSSEASSAAPGDDSREMHNEDSASRQQIASDEELSFAKDDGPAYVAVRDTNDHDGCDASSMVTFDSERTGAHDMRQDPIENRSLGAKSMMIATRSMTHETIQEVPDTVRDSSKEQKDGGYSEASSAAPDDDCRGAHNNEDPASRQQVAPDDELSFGMEGGRPYVRPSKEEQIRFNDELSQLLKETSSGMGWTDPEVAKICNTMTSQKFDEEQRRLWDELGHQLQAKGLMDSDVALQYSNIAMHFLVEGRLEEAMELFQQTLNIEREVFQCDNHLTMAATYHCIGIVFQNQGNYEDALKQYQRVLEIYVKALGPEHPDTASTYNNMGVVFQNQGKHEDALKQYQRALEIYVKALGPEHPHTASTYHNMGNVFQDQGKNEDALEQYQRALEIYVKALGPEHPHTASTYNNIGNVFQNQGKYKDALEQYQWALEIRVKALGPEHPDTASTYNNMGTVFGKQGKYEDALEQYQRALEIRVKALGPEHPDTASTYNNIGAVFQSQGKYEDALEQYQRALEIRVKALGPEHPHTASTYNNMGMVFQNQGKYKDALEQYQWALEIYVKALGPEHPDTASTYNNIGNVFQNQGKYEDSLEQYQRALEIYVKALGPEHPSTASTYNNIGNVFQSQGKYEDALEQYQRALEIRVKALGPEHPHTASTYHNIGTVFLKQGKYEDALEQYQRALEIRVKALGPEHPHTASTYNNMGNVFQSQGNYEDALEQYQRALEIRVKALGPEHPDTTETCEMVEMISEINRSFCIKFFVTILVKVHRVAMSYNSKAKVLLASIVGKLSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQJ8</accession>
    <name>A0AAD2FQJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041956099" description="Pentacotripeptide-repeat region of PRORP domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1949683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="53117" checksum="F14B77629C5253E7" modified="2024-05-29" version="1">MRMIGSSRLPLLSILLLSIFQPSVHSLLSTKSCQNGNGHRIRLLTTSGAYSSHPRKNPSEEDQGLLLAKRPSTAGAGVDANSSEDPFSASGGRSLVTTVKGGLANIFEFAEEQKARNKRRQELRRAQRQKANLKQGGGKEQPRWHPYSGINSSNPNFRTAAPVMTNAGFAKSIWRNARKRNKPVLWENSLRTYDRMAILEQKTELKIKRTNLHHEGAMLACAKLGWWQKCLEIYHFVNEQDSSTILPPTASSRLAPSNLESSAASSKIVRRVYVTDNMIQSLVRACSRASSQRGKGGSSSSKQQQQQQQQQANSQTTTTSNADEQESLEEQEVALRRIPLDTALEIVRTMDENHGVKPGAIHVNPLAAAYQSLGYTEEARDILQTMLSNRTAGEEPEEGVDILNVHDLCAKDKGSYSLLVQGAVGSGDWGAAVEALCDMTKSGLYPNPRHCNSWNEIAERHRGRSSKKKIREEFWTNSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQW8</accession>
    <name>A0AAD2FQW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-methionine-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS12411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050162">
        <property type="entry name" value="MsrA_MetSO_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799:SF2">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="8">
        <location>
            <begin position="8"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1950078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="185" mass="20998" checksum="15A8E47A9720A16D" modified="2024-05-29" version="1">MAPIASTLALGAGCYWGTEKYIVKDFQKKHPGCIKDAKVGFMSPDQDAMKNPSYRQVCSGSTGHVEVLNVELNDPALFEDLIRFFFTFHDPTTLNRQGNDAGTQYASVIFCSDEDQVKIATKVKEELQTLMDGGKVTSYSEKTIKTGIVSYTDFYPAHEEHQEYLEKNPSGYCNHRYRFRDWPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU16</accession>
    <name>A0AAD2FU16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001795">
        <property type="protein sequence ID" value="CAJ1952047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="49"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1118" mass="125819" checksum="BB7261D3155780CB" modified="2024-05-29" version="1">MRTLHTHISKRVEPPKCAACCYAKAKRRAVAKAKTHARVKDAPSSLRANTLYPGQEVSVDHLVSSVPGRTYTGYGKGHKSEMFRGSAIFVDNATGYIFVQHQKSLNTHETLRAKEMYEANCRDLGVVPQKYRSDNAAVFHSHEYKQHLEAFSQTQKFAGVGQHHANGIVEKAIQDIQSTARTLLIHLAIRWPKQADLALWPMAIDHAVFLHNHLPDVNTGLTPMGKFSRQRWPHSKYHDIHVFGCPTYVLDKKIADGKTLPKFSPRSERYVHLWFSPFHASTVPLVLNPRTGAITPQFNCIFDDWFATLSSKVDDVPTFMEEQWQHLFGDSQFQFPTDDNDPPSLTPQSQVPLSYELSALDSFEPSTSHYAGTQPTLSDPSVFREPSQPSFERESVSVEREQSPPANIPSSTNTGNPTPLPLQREQQTQSKSPHKTARETPIDLPSSSIPPTSSSGPPLRRSTRSTRGKPAPILDPNPHSKTYVSKPLPSSNLAEINPSNDPDFNDTENLHSFPKDTPFLANEDLVLTTSHPSYRRFKTQPESDDGGICGFYDLHFSYLGYTTTNTPKFVFLDSKAPPDSIEFLKTGTTDPDILSWDEAMAGPDRDKWREAALKEIRALEHKRTWLEAPESNATVRVIPGTWVFRVKRAPDGSIIKFKARWVLRGDLQDLDMDTTAEVVAWSSVRTFMVLSLKLGWVMKSIDFTNAFLHAKLPDNLEMFAHLPRGFYSNMRSITGERTVLHLKKSAYGTTIAPRLWYKHLMKAFHELGFESSSYDKCFLIRKDMMIVVYVDDCGISTDKPEKIDELVNQLKEKGFDLEIEGDFETFLGVEIRQMKDGRYHLLQEGLIKKVLEAAKMTDCSPNHVPAAPTPLGKDPNGEPWSQHPWRYSSIVGMLIYLCTNTRPDISYAVSCAARFNSNPKVSHATAVKTILRYLKKTSDKGLIVNFNGTLDLEAYCDADFAGLFKSEAPYDPAVSRSRGGYIIFLGGVPLIWKSSLLSCITLSTLEAEYVQLSRSMTVLLGLKNLIEELLPRLQLPNLTAFVRSIIFEDNAGALLLAIGQRITNRTRYLSQFYHHFWSFVHRPQDGPPQNNPNGPWHDGKIKVSKITTDKXXXXMNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU20</accession>
    <name>A0AAD2FU20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Association with the SNF1 complex (ASC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:003294">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="213"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="302" mass="33227" checksum="10D51422B001F40D" modified="2024-05-29" version="1">MGNQQPGPPGGPQPGDDPRQRNRAGMAPGAYGGYPIGVGPGGGYPGGQQQVRRGSDTSMTLLDADKTAAAIAASGDGTIENWIDDDTVPTVFRWEHGGRQVYITGTFNGWSRQIPMHRSGNDFTYIHNLKRGKHAFKFIVDDEWRFAPDQPTVADIEGRINNFIDVTDFKAYTGDREFEKEKAAAEYGYSGDGTETVYTDQQSAASDAGPNQPDKDGEVFSRLQPDLDDFTKEPPPLPPHLRHIILNKPPQLQDTAALPVPQHVALNHLYCTAIRDNMMVLGITQRYKTKFVTTVYYSPCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUU3</accession>
    <name>A0AAD2FUU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUU3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1953683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25008" checksum="1DD4152FF221F61E" modified="2024-05-29" version="1">MNRVFGKKKAKAPPPSLDNAAAGLGGRVTAMDQKINGLENELRGYKEKMKKTKSPAAKKQLQKRAMEVLKRKRMYEQQRDTVAGQQFNIDQASFGIESAKANIETVAAMKAANTELKRTMKNDLDIDEVEDIAEDMAELMEDFNEINDALGRSFATPDYLDEADLDAELEMLEDELEDDALELEDSTPAYLQESSSMPAVPGKAFPEGEQKEAAKTDEFGLPAVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVG8</accession>
    <name>A0AAD2FVG8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="144" mass="16144" checksum="0523E48EF48C63C7" modified="2024-05-29" version="1">MGPSRELPSVLLVRKMRKGHGLGRRKKEEKGQEDGDSENDIAKAEEFKDEEQEEEEEQDQEPAEFQPDEQQWCFVKGAADSLNSNAIIMKSISTGLNLGIDDDGQIKFGDDDAPPRKLYWSIDCVAGELCFLSNESSFEVTSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVU2</accession>
    <name>A0AAD2FVU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVU2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="151" mass="17466" checksum="A35542E690B37787" modified="2024-05-29" version="1">MRVSRGPMNSPSQQIIPFLACMVLGAALHHAFFLNKSEPRPRIPGTAWTLTVTFTFTDEEDQKQILEEWRSVTKYCAEKEPFLFHYEVGRSDADPLKVHMVERYKSKDDYLTKHKTGEEFLKFRPKLKALQDAGKVTIEGFSYQELGYGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWI8</accession>
    <name>A0AAD2FWI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="564" mass="63514" checksum="21305006910B3A65" modified="2024-05-29" version="1">MPLVPRFELSQTSSEVIVLVFVKTIRLESIEVVLDEESVLHFHAHPYSLTLNFSPHQFDAEAQGIVSAQYDPSIQTISIPIMKANKGSIWPNLDMTARLMHPKEIPKQWLHAVVDSTENDEKTIMNDNSSGNDATLTDANTDTTQTISAPSSLSSSYGYGFGNLFQNIFTDYCRSGVAQEMLSLPDPENTEPSKRQSQRIDQEQEDFDPDRYDYDIQDDYLYEMVIDFVPFWKQPKKGRAHANSESNVDDLSESLETKLNIGNKASTSDSPFTADEKLQLSTIPYPLIPDHLLRIPTGTGSESLWCGLLDLLIPYVYDHLMTMGDPTVESAWTITKLSCSLSWLDPPKTVQEALIGSTRRMLIYPYWRNLNFSVTVWEHLLSILESNNGLHSVIKCLLQLRSILEKSEFYYAGNKVFVDPYLYWVQHQDAAGLTRVANKVRNELDMGTLKGDVDLDLAIYENLVFGEENESGHDDTASSSDESDSEEEEDDDDDSTIDSNSKAEENQKDLQQQQTTETSEIQKVSSTLLDLEDDEAPRSHVLNIVEEPSSEPSVGGKLLIKELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZF6</accession>
    <name>A0AAD2FZF6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZF6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="652" mass="74922" checksum="C59301957E6EE287" modified="2024-05-29" version="1">MYLQRRIAKKLQAVVGGKIEEKLFFGTIDKAIHKTTKSKLKKRRLKHAPPDRWHVTFDAMDGDEEEKEDGDHHFDEVLNEMEVHNALELYAKHCKQDPHGIDETSLLLANQYHQQQKYMSKGAGFGGGINTRPMSSLALDASEHSSGESVHGHPPTDIPVSWPYQSKHKKPPLNKAAVAFILFFLFAARSIASVANQHGNMTQFWIIPVGDSSSSSSWSGSTTFDQSSAVRLDKNSDVAQHAKHAQHTRDAQLSASFHANNDHHHQQQQSFSACLLWMDDNHRLPEWFAYHYFALPLRHVILAVDPHSSTQVSISSHWQNKMHITIWQDSDYTVTDLTRKPGDTKNDLKGKHRQRQSQFYQACCRHLKNLNRTYTTFHDSDEYLTISEEYYVKQQQKQKQKRQSQSQKYIHHASAEFRRQPGHILTLLNEYNDDKKQNKKKKKKKETTTTTTDTPHEDLAQTCIHVPRALYSAVESQTEKRNKGVPDWLLQDANHQDKYQYQLDTLRYRHRLTERGGRDGLGKAIIDVSRLTKEDIDEGGTTHRPLKEVCAAETPWRDYGSFPLGIHHYLGSWESYSFRDDARKGTLRRRDIWLSRAESEQGGSDDEIREWIAGFTKATGDDLARELLSGAGLSRSDIDEKNASNHWQSGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZT0</accession>
    <name>A0AAD2FZT0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="550" mass="60642" checksum="4EB23AC54468EFFB" modified="2024-05-29" version="1">MTSYHYFGNEGETIPNDVKELKVHPLVRHIPDEACRKFEQLTRVNFNGSALTSIGKLAFYGCTSLLEIEILPTVTIIGEAAFAVCRSLTRVRFHGDGLLTIIGEEAFYECSSLIEVSIPSSVEIIGKYAFGTCKSLTKVCFHGDGLLATIGDAAFYECSSLQEVNFAEANLKTIGAKTFRNCVNLQKINIPSTVGLLELAAFSDCRSLLVVKVQNGLNYLAPLVFCGCKNLQAVALPESVEGIGPAAFAQCGSLLSVELGDRPRTVAIADMAFAECKSLVNICLPPSASSTTTTSTGAIGYTSFDGCTMLENQYGRDANIFPALQRRFENFPMHKKCYHASVTTTDELAREIESSMHSKQEGSTHLVDPFGLTPFHVLLSAATCRLDLLQVLLDAYPPHVLGWKDVHGNTAVEYLTQRSFHLDEDSRQMHRMALQGWMVGCISSWNGLKAWKSDMSDKVNAIVAENDVEHRQFLLREATMILSRYEQMESTMLLELSLWKSEMKFAAFASVDDTERTTVKVKDRETHRIRSGASVVVPNVIAFCFEANLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZY1</accession>
    <name>A0AAD2FZY1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042141259" evidence="2">
        <location>
            <begin position="19"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="438" mass="49149" checksum="CB8D009ED6D57A58" modified="2024-05-29" version="1">MLWRVLLAFLWMFLPSTGGDILTLDDLQIINTMIRQGDDVMIRLEPTKASAVRQKTVCRRMRNKLVETLEKAHGLSVRSEAAEAIRLCTASNPQNRADFALENSGTVYSGLKDVIDSGLKVHNATEDAARGERIKAIQSIAKAAEAIWILTFNNDLGQEEFFRIGAVDSLIMVLRTCHIENSENGKRYSHSSKAVMWSLAALQNLAATFCYSETGYCQWIWNDKGELVMTGAKPRSKIGYKVRQKIMMHLANTDLSAILCSLICLGPVSKPHGRIYAWPSQSNAHAHQNFPSIIPWAAIGFVKNLALSEDVSRLWKENNQLFECLCVIAKRSPDWLEIVNAEEALHHLGWRDSCPSFHDRCSDYPKWTFLDSDEDCPQFEEERYCATYGETKNENGTSANEACCACGGGIPNKGKADTNHNNMNNNKEEEDKSSYQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0J7</accession>
    <name>A0AAD2G0J7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0J7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="554" mass="63965" checksum="B98376B20C99ED26" modified="2024-05-29" version="1">MPLRIDKKGTEESSQNEKAKSRLVLRVCLVILFLAILHIGSEQTGLKGFRGNALFPASTSSALVWKSSSSSSSSSSQQKEVILDLVDDEQEYIKWLVEEREKVSNVTEIKTPIKVLYRAMAGLGHQLLRLSSAYHLLTIYQIPLIWPTANPVCGGTIFTIYEHLIGKGPLFVDLPYLKEKNSYHMEIIALPLRFPKLEFVNETELSEEERQELVRGINLNNEIPGYSHAVGDVWDMDLPRFQEMDFYNKFQTDYQMYHQLMLLFEHKHRTKINEIHEKTRFSSHTVFALHIRTGNGETGDFEKKSRGIKNLEQWTETVIELLCDYRERNSPLFDKKPLMIFVGTDTGSIVPKLQNISSTLCQIPIVSADQAYPEEGKSVSFLQKYDNDEKCLQGWENMFMDMYFFTKANTVVTGSYSSFTQAAPMSFVMHRAKKNGMLNDNSHPHLFCELNRYGNRMDCFQDFENWLRRNAVKYFGNMSSPEQRIRQELPFPNWRIKSISINKLFAKTLLREPADSKKPSSSSTNRMTFQEWMALNEIATTNNTKNNMKKKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2I0</accession>
    <name>A0AAD2G2I0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS16904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2I0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1957845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50936" checksum="C12417EF3D781D95" modified="2024-05-29" version="1">MVADGFSQHRSVNSFTDTFSTKSGDDYDHFSRITDNSSSAKSPESSQAENKRFEKDLKSRHRTACKEMDNGKYRLAIQSFEGILADLLTRYDMNHERIGTALHNIAVANLRANELSDAKDAIEEAFRIRKAALGAMHPKVGDSLVEFGIILMALKENDRALKVFLEALEVREEGMTNAKECQERHKAQLYMAKVLHNLGCVYTELDQLDAAQETYNKALEHQKAAFGEWNGNNLNSKSDSTKPGFLTMASTICNLAYIELERGNHDRAIAFLNDSLEIQKVLLEADNKLILTTMQNIAYVYCLQSKYANAKNVYMDVAKLQQESYVAHAKRGWNASIKSLIYCQLRDFDFESAFDNLRKLEDVLSTQAQIESAPTSRDLQTTHELMGEVNFQLARLPSITEYTQRLLVGQGCGLCADACQPGEFRDVIDAESWFPKRPTKGSKMTGHRMSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2N3</accession>
    <name>A0AAD2G2N3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS17926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2N3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1959505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="435" mass="48651" checksum="C2D61649963189B3" modified="2024-05-29" version="1">MPNFPYKLHKLLERVEEDEELKSIISWLPDGKTFRIHSQEAFEKRLLREYFPRQTQVKSFMRQLQYYDFENFGEGIFRHRCFVRGQRNLCGQIMHQLPTKNQKKSGKSTRPLKTRGRKKKTTTLAASDPGSAGSTTSQPAEASNGVASVSAHRTSSPQPSLGGGSNSNTSVSSDSSESTHSETNITHEQVEEHQKKKARPHVEPASAKPPHVSLPTACLQGVQLASGHVQNDAGRGFPLHNPMSTIPSSQQSFAQQLLGQHSLFAAQNVMSNYRSGLQAEELLLSSMLHNQRYLATMLQAQQQQQQQQQQQQLSQQPTQQMPHPPSIQGGMIPPQGVQLPLPNTNNRFLDSRLPQPFTSSHLERLRANAISNHLRNMSSLTTSPSSRHRKKEEFSSSSPNKKRGFSSGGDDDDDDDFDSRNKKGSASSHHQQQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G383</accession>
    <name>A0AAD2G383_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G383"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20251">
        <property type="entry name" value="Complex1_LYR_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47579">
        <property type="entry name" value="COMPLEX 1 LYR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47579:SF3">
        <property type="entry name" value="COMPLEX 1 LYR PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="1">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="101" mass="11709" checksum="28B5CA2CA6F0C494" modified="2024-05-29" version="1">MSGPLNRTSLELYRDCMRLVRHLAPGHSPKGTALRQMVRSQFQANRYEKDPTIIEAKKADAVRALSNYMLYQSAQKDTQLQNAMKDQVKNIKKENEDEDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3E6</accession>
    <name>A0AAD2G3E6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS18931</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040002077">
        <property type="protein sequence ID" value="CAJ1960873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3E6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="122"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1960873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="430" mass="47754" checksum="F57FBF9392792DAD" modified="2024-05-29" version="1">MAYRGHFLATSLPRGLKARATPMPQLWAVRGFSTSTAAAPTFESKVVVDRYSPVRQESERLPNDEYERNSLYTEEDSRQMGGVTASVRHDWTKEEIAEIYDLPFHELMYRAGVVHRMYWDPSEVQQCTLLSIKTGGCTEDCSYCSQSTRHKTFVKPTPTMKVQEVLQAAQRAKDAGSTRFCMGAAWRELGNKKNAFNHILEMVRGVNSMGLEVCCTLGMLNAEQAKQLKDAGLSAYNHNLDTSPEHYPKVITTRSYEDRLNTIANVRAAGISVCSGGILGLGEQEIDRVGLLHVLATLDEHPESVPINALVSVEGTPLGDDEDIDRVDAFNMARMIATARIVMPRTMVRLSAGRMTFSHAEQYLMFQAGANSIFNGDKLLTTDNPEFDEDQAMFQKFGFRGKPAHKGPLVAPAEASGEVLITKTRTEQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3N9</accession>
    <name>A0AAD2G3N9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS19314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3N9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041771939" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="21"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1961673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="646" mass="72807" checksum="249B17EC6D1364C0" modified="2024-05-29" version="1">MRLPLVVAAAAALIFPSVEADNVDHRYKKDEHVELWVNKVGPYANPQEAYEYYALPFCAPDTKHHPDAPGGGGRFNEWKGLSIGESLGGHALRHSGHDIAFLKDGDPETCTTKALTQDEADHFAKAIQHRWFYQMYLDDLPVWGMVGEMLPKADQLKSKEKDDLARLDHMEDLSDNEIKDLHPYVYTKRNLVISYNKDQIVKVDLESDTSSLQEVKAGAQLEFALHVQYVETVEEFHSRFDRYLDHEFFKHPIHWFSLFNAFMMVLFLMGLVALILLRTLKKDYARYGIMHDLEEGDDMDEKEALQDKVEDSGWKQVHGDVFRSPSLLALFSALIGTGWQLVVLTLGVIVFAVLGPLHGEVHEGRGEVMQAIIVCYAFSSIVSGYTSGNYFKSYAGTVQRKGKETSVQWQQTMALTVILLPTVTVGVFATLNSVALAYGTINSIPFMVMIKLFFLWTLVSIPLCVVGTLLGRHAHKGTANPFPCRVNAIPRPIPEDVPWYGKPSGLIPLAGLLSFGSIFIELYYILTSLWNYKFYHVYGFLLGVYGILTIVVGMTSIIVVYFCLNAENYLWQWTAFGSGASTSGYVFLYGVYYYIFKTHMHGLLQMTFYFGYMTLIALNLGLLCGTLGHWAASKFVKAIFQNVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5W0</accession>
    <name>A0AAD2G5W0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Copia protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002175">
        <property type="protein sequence ID" value="CAJ1964173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5W0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17609" checksum="CB8AE76B1FF98A1D" modified="2024-05-29" version="1">MKWMIGASFAVHPDFKSHTGGTLSFGGGAAQVMLKKQKLNSRSSTEAKLIAVDNVVMMILWTKLFMEWQGYPIEKNILYQDNKSAILLEENGRKSAGKRSQAINIRYFFITDQVEKGNVKIEYCPTDDMIADFMTKPLQGEKFRNLRDLILGPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5Z0</accession>
    <name>A0AAD2G5Z0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5Z0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="230" mass="25334" checksum="90DBDD0F856FBDF6" modified="2024-05-29" version="1">MTESMTPDQIEFTNAFNRQRVTLAGFAQCANKEELHKVRDGLYIGLASDLRLPEYDTVATDVIVDERVADSVVTGSGYGQMIETARESAGWKDLVDAVDKKAEAVGSDLQGIWMGLENGRLEWLNAINGAHTIKVLLKEGLEKDGATNSPGDVSDAKMIWIYGLCLNIPKLKPFVEAWCKVVELDDMTRPLVGYKADLWDARKDEWRALDIGAQVAAERGGSSIDQAWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G670</accession>
    <name>A0AAD2G670_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS18989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G670"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="647"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="748"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1960999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="772" mass="88364" checksum="4DA5D5B652168A7F" modified="2024-05-29" version="1">MSDTNPKPALDRLIEVFDDPLETILPLIHDSKDKKVDRADLVNIIKELFQSTEKLAKQYQEISKKNEEDAPTGLSGLSEVIGDESIDAETLWGQVELQNKAVNKLVKKSKKKLEKAPEKVCILDMKQILSESEDDESLGSQDENSQKSDDEEGNDDEEGNDDEEGSVDSETRRIRERMDRAMDEMDEMDDDEGKAEGFKGDEDSDNDMDERKKKKKVSEEDEESLVDPVADQMKDGFFDLNEMEDFADEEEDYLPEEAFGQPKKEKKKKDAKSFHQRQRDGDLANASDSEDDDFEDMYEDIQPTKRKKYRDEKEIDALYTLYQATGTENDNDDESDDEDDPANMTAGDFFGKPKMKYYEKYYKGNKSKQGSAPTKTKEGDDDDDSWGDYNFEKEDQEGWRDDHVEDSDEEEKADEKEDDDFEPLSKGLKDTKQSVDDSAHGRKLAKLRRQTEELEKEMLAEKPWQMTGETKSTTRPLNSLLEQTPEFEMASKQAPTITVEQTASLEEVIKNRILAEDWDDVIPRELPDVGWNKKRGELPEVSQEKSKLGLGELYEREYLKKAVGYDVDAEEKKSDEDKAKDEMKQLFANLCSKLDALSNYHFAPRPVSDEADIRPVTAPAIAMEEVLPLHVSDARGVAPEEVYATKRGREGIVRDESEMDQQDRKRLRGSKKAKRRKARKEKLADDKLISRLEPGLGLNNPYEKRKMREELDVARSRGKITMGEREIETKFASSGTFFKRLQNEAQDAIHGKSTQAEKKPKVAKAKSSVYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6Z3</accession>
    <name>A0AAD2G6Z3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS21017</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6Z3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="12">
        <location>
            <begin position="333"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="506"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1965239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="682" mass="73183" checksum="7183B259CDCF2DE8" modified="2024-05-29" version="1">MSKYEVVSTNRVAGGGTYQRIKHESTSTKTPMIFGLFLPSTHATKQVTETTPALFWLSGLTCDDTNFAMKAGPAAFAAAEEQCIALVLPDTSPRGEGVPNEDSYDMGIGAGFYVDATEEPYAANYKMYTYVTEELPKLVEESFEVGTVKSISGHSMGGHGAMTIAFKNPTAWASVSAFSPICNPTQVPWGEKAFKAYLGSVDAGKAHDATELLKGLQSSCFDDILIDQGKDDNFLANQLKPENLTAVGGPQKVTVNMRSGYDHSYYFVSAYIKDHVAFHGARLNKAQGKLRASRSSYDFSSTTGKPIKCKAMVARGPKQPLTEEEITVDAPKAGEVRVKVIANALCHTDIYTLDGYDPEGLFPCILGHEAGCVVESVGPGVLSVQPGDHVIPCYTPQCSQTSCIFCMSPKTNLCPEIRSTQGQGVMPDGTVRLHDKDGKDIFHFMGCSTMSEYTVLAEISCAKISKEMALSKACLFGCGVSTGLGAVWNTCKVEADSTVAVFGLGAVGLAVIQGAKMAGASKIIAVDLNPDKFEMAKKLGATDCVNSSPDKIDKPIQKVIAGDMTPWGVDYSFDCTGNVKVMRAALECAHRGWGESCVIGVAASGHEIATRPFQLVTGRVWKGTAFGGFKSRRDVPQLVERHLKGELPIDHFITHSFEGVNKTNDAIHALHSGDCLRAVVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7G4</accession>
    <name>A0AAD2G7G4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7G4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="377" mass="42159" checksum="3E5F415BC189B9D3" modified="2024-05-29" version="1">MFGFGKKTKEEEQVFEHGIQKGDHLIRWTSILIWPVQVHAICIGACHDSLTLVDFGLTANKQPDNSIDKYKSENEIENETVPLEEMVDQQDKALIKAAEERRSQMRGAERITILTLTDEKEIRQWKKVEYGEEVSKKKNKWWFWKSKDNDKESKGDNEKDEIDDAKVEQEQDVEKDDLNVSNDTSTSPTTTVKPNGPASPKSDPAASPPVPKLPKSDPTNIVLARVRYLLMNPEVLPPHHILFSNSECIAVWVKTGRWSTLQASVFLQATTVGNIKNTATITATLAAATTTVTVPASGVMGWLGFTTTTQVGLMAVHPWLIPVLAGYGLIAIGTPMIILKKCKDQWKEATQDLTEGFWEWADSDIYVEAIHSWSGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA26</accession>
    <name>A0AAD2GA26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002295">
        <property type="protein sequence ID" value="CAJ1966531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="548" mass="61012" checksum="3B2EDFCA665AC9E1" modified="2024-05-29" version="1">MEWPTDRTSGTAMAVWRHAAEAALVDITQDREKITPAIENFKQSLAACENFRTEYRNIIEEFVTIMASASNEQALDMAQAGIDALHSLMIYRLDSHTAVPAKDAFVVTSSYEKLRTVHIQGTQEIDSSDFQLPLVNPANIKEELYGHGACAQVDAWQQYGVLETSASVYAKTALVSRSLPSVAHRKKFCLLGCTSELGPARSLLLIPGAEVLGVCRGGEKYTSLLQYVEARSPVTTRLTVPENGADILTQGPEIAQWILDQTKSEDTLVLMPLAYADGEMNVRLCVAMDLIMQRITRQRRKAIVYQYSTPTQVLVLPPMAASAAQNRLGKRPTWEKFTSSLSLGNWLQPSLPESNNDYCILNGIATAQGPNYILAKTLQMWRCMIAYYRDDLCVSAPFAPICRTRSVVAYKSIAIVLEGMHHFEPMLAFDASVASSLMCAIMMSQIQVVNRPVPDMDENPFTLFWDGSAHGGVWTCPYTLESISTVNWMLGRTMYPKGYIPEAALAKEKTPEEKTKRTMAAIKALEEMEQSQFGKPMPECVRERLEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAB9</accession>
    <name>A0AAD2GAB9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAB9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="313" mass="34553" checksum="E6B286139B0FEAFB" modified="2024-05-29" version="1">MSNSDKQSNKFAWSHYEAIDLKGKGRQETFTIRHLKQGSTGAVSTWPVASVLLDYLVLRNGLARKVPSVDTLNMADNSLQQQESTDPLAANDDNESYNIVELGAGTGYLGIGLALSLNREANLSSKEDGVRFQPKVRVMCTDNDQRTIKNMRFNVMDQPKEGMLSKAVTVQNLAWGTDVGGTKFSNAIGSQFGSRQKNKSEKEEKEEDPLRLVTHLIASDVHYGVTTLDPLSSVISAFKLRNPNVVVIVLLKERSPEVYADVTGLKAEIESKVQSGLGDKECSLDTQTALKDFFVSVRDVIHHDITNMKMVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAL7</accession>
    <name>A0AAD2GAL7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002342">
        <property type="protein sequence ID" value="CAJ1967720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAL7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="323" mass="36041" checksum="B994931C0DC94E40" modified="2024-05-29" version="1" fragment="single">MVTLRSNKEYNPTRKTPTKKAGKTPRKPTPSKISSSSKSGESSRSRTSHQHVWPLLLEDIEVSGGIQRLVLEGGQSLERLLKDVIAADEANPTGGNKLELYGRKGSAEREVIRMQVNRWKKQDAKQYRSTLERYNILAFANRTIKIEDSLISALSTDYEGDDSDSSLASSRPPTLAPPQTQRKTKQRLKYPPPATKRPPAPVSKSLPIDKATPSTTHPLLPPESSSPQELEQLDESNNTMSDMSEPKVYNPENKDPMHTWPFVVVKIKSLEGVDEHQGELYEGRPDIVAETLKRLKENRSAKVAENRKRGDSTPSSHDKSQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDE2</accession>
    <name>A0AAD2GDE2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS23715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDE2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042067111" evidence="11">
        <location>
            <begin position="24"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="314"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1969450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="593" mass="64464" checksum="E5B929A9085432D7" modified="2024-05-29" version="1">MRQQCFLLAHLVTAGCILHSNEAFVYQRPRIRGLQKAPLLPQSKNTVTLHVTPPESDSSDVLSEETYSEQMTIEPSETTDIEPTATAGMEGDELFFASVVEEGNDLLEETSSIYVTPPMPMPMPNQIDKKVDKESSSLLTRRAWFQTGAVVATGTIAAAATIMNERALEAKKQANTFQPKVSPFARANSTAAKTGAPKATPQKNAAQPATTAKTTGAPKATATPNGIPTKPAASVNPVKRLEATEAEIIKKLEPVNITQVAAETNVNITLNCQDACVSIDPVTLTKVQSKKMPTWVPSWLVPRPKVIKQISNAELLVAATIAGSMVDVGRTSLLYPIQTVKTRIQTDINNSTRTFVPVKERMRTFGSNVKRHIDEGDLYAGIKPTLLVSVPATGIYYGVRDVSKHVLAMTPLNGIQIALLAALIGDIVSLCFRAPADTLRLRLQNQDDNVGDWFADSLKKLPQIIITDLPYLLSKIALNRLLIHGSISIDQYTEYAIITSSIAALLTTPFDVARTRILVDSDMDCSNGLDGGSGEGVIQTMKCVVKEGNGGYANLFAGWFERVLYLGVGRAWFEPIQLIGYIGIRDTVLLEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JG96</accession>
    <name>A0AAD2JG96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7467 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055890">
        <property type="entry name" value="DUF7467"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24269">
        <property type="entry name" value="DUF7467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042078644" description="DUF7467 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7467" evidence="3">
        <location>
            <begin position="1133"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1406" mass="148720" checksum="284E7162F88F4801" modified="2024-05-29" version="1">MKLSAFILALLSTQVVATTIDAGAIKEQDFTNEDFEFFDRELQVFSLTPAPSSQPSECAEVIEICPFDSCFLPFSDPSRPDTCGANDQCNMLPQPTGRGCSCCPEECAPDNPMFSPSPDGSPPVCSPTPLPSQAPSDCAEVIEICPFDSCFLPLSDMDRPPNCSPNDQCNMLPQPTNRGCSCCPDECTPENPMFTPSPDGSPPACSPTPLPSQAPSDCAEVIEICPFDSCFLPFSDSSRPPTCSPNDQCNMLPQPTGRGCSCCPDECAPNNPMFSPSPDGSPPVCTPTQMPSPSPTPCSEIINFCPVLCFSPNANLRPDLCTNIGRPDCDSIPFDMNCPTCCPTICVDFDPDICGAPTPVPTIMPSAAPSDCAEVIEICPFDSCFLPFTDSSRPPTCSTSDQCNMLPQPTGIGCTCCPEECAPDNPMFSPSPDGSPPVCSPTPLPSQAPSECAEVIEICPFDTCFLPFTDSSRPPSCAAGDTCNMLPYPTGAGCTCCPDECAPDNPMFSPSPDGSPPVCSPTAMPSQAPSECAEVLETCPFDECFLPTTDASRPRDCTDPSINRPQCNQLPFPTNAGCPRCCPDECSGDNPMFFPSPDGSPPVCSPTAMPSPSPSIPGDLATDSPTIQPSAQPSECAEVINSCPETCFLALNDGNRPQDCQDLTSGEGAQCNSLPQRGNCDCCPNECSPNNPLFNDNPDGSSPDCQPTAIPSPVPSPPPTPIPTPGPTPIPTPGPTPDPTPGPTPQPTSCTYLIDECPTLCFEVDPDDRPPSCAILGNTFCNALPNPNVNVCSCCPDECLNPQDRDDCAPTPVPSPQPTPGPTPFPTPPPTPLPTPPPTPGPTPFPTPPPTPLPTPPPTPGPTPFPTPPPTPGPTLPPTPGPTPFPTPPPTPVPTPFPTPPPTPLPTPPPTPGPTPFPTPPPTPLPTPPPTPGPTPFPTPPPTPPPTPFPTPPPTAQPTDCVYRIENCPVACFETNPNDRGPLCSAIGLVECNIVPNDPFRCQGCCPDDCINAVLDGCEPTPVPSPVPSQAPSPSELECQLELDFDTRCEFGCKFDACTERPYTMLMFYNGGGCGGTQFRRCPGENPDACTCTKETLPCELWNNNNECEDFDLNGNVCDNLAQFCASGQVNRQTPGCGPPPPSIDHTVYIEAFGKEELYFAGPVQVNRTWTAATVGDQVEANTDIFTYEWIPGVGKGRLLQRVIFHSSCSQEMYLTDQFGAHQIIEFDSFCQVSCNDPSCIEVTENGVTFGRRRISLFLETVSDLSLELRTNAVQGSVLLSQVLAIFTPLDFSSPTELFNFSDVTGLTVPPAITVRPVSTNIFIAVDKTYSIGAVVTGFLNGNPFLPCQQVGTTELRCEKSADIPCECPPCFGGGDPDLFFGDGEGDGIKKPKKQATGPSIDFFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH79</accession>
    <name>A0AAD2JH79_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH79"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="20103" checksum="4BDFB789709060EC" modified="2024-05-29" version="1">MGAWNAAGNLFRLLIVVGTVIAIGLQSATQTGCNYAVYKEDNIQAVGIWYLMTNNECGAEVYDPDESDPFIWTARSCLSLSMLLATIGGILVAFEWCCCNVCCAGCIEMSCYMSAMMLAGGVNFIFGCELCVGVGFDSITVEGIEAAAEDGNVCEIGPGATTNTVALIIYLIVCILLCCTPEPDPVWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIB9</accession>
    <name>A0AAD2JIB9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIB9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="148" mass="16346" checksum="0DCE99A9CFA17D58" modified="2024-05-29" version="1">MNSAHAARQQLDRIFAFDAAFSLIFGALAILAPHGILTALAGGFYNHSVHETLRLYGCLRLACGWILWHARAVDDGRFRKHICEALFVCYVLQTLAILRAQFTDRHSLINWVAILVMGVLGAAYASFRFGKGGNLIKVYELPTGANII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIC3</accession>
    <name>A0AAD2JIC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001835">
        <property type="protein sequence ID" value="CAJ1953569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="188"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="331" mass="37471" checksum="5CCE4BC0FBBF9A1C" modified="2024-05-29" version="1">MISAQGTIAIATNDAEVTSEALSLFGFTKEESRKLLFEEKLSWRETKETMKSMAPQQVWQQVFTYSMCKNIQRQHLLDKTEHKFLTMYARPKQAKKHLTAIVSRSINPFTTLPIPTGEDWREKCNGDPDISHIIKAIRNNKKVDRSKLTNPTYASELNRDKLEIENGILYQFEEPKSAPMRQLRRAVVPPRLRATIIAAYHASPMAGHVGFHKTYYRIAARFWWPGMAKDIREAVLGCGHCNAANALSHKNQKILQRTPIEEPFDVCCMDVWSPGSTKNATKLSTTLRKTLTNKGVVTYVCNMTGCATVAFISSMDSGNMARIAFSQFFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIF4</accession>
    <name>A0AAD2JIF4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS13883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001819">
        <property type="protein sequence ID" value="CAJ1953128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIF4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028307">
        <property type="entry name" value="Lin-54_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446:SF34">
        <property type="entry name" value="PROTEIN LIN-54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446">
        <property type="entry name" value="TESMIN/TSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRC" evidence="5">
        <location>
            <begin position="93"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1953128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="506" mass="56054" checksum="02F2ED07A677AEE5" modified="2024-05-29" version="1">MDIRVLQVMLVHQPRQRATAVPPRAHVGHDHAAARRHFLLSHHPRGGYDPNGYPNQLYAFPEPQHQDYVQGPHDARSSPPKDSSISDGSEGIRATNCTCKKSRCLKLYCQCFGNSTTCGNKCRCQSCHNTMQHAEHIEVAKNAILDRNPNAFDSKFCGVPVPHFFGNGIVKQPTNWHSARVACTSKSIQQTFSTPQRFNKLGCKCRRSFCLKKYCECFQNQMNCGSHCGCLNCKNHSPQAEAPRRIALVEAIIPKETRVGSKESVPLDKDVSASEKLSAHSKSEDRMTMIAAVAMTELFGKAPRQASGGTSKGAGASEKRKFHNKAKSSQSKKGALRASLGINHMKLRSPSSVCAFIPQSRRYNMSNGGEHGPSRHSYFPIQTSPALFQYHHRPPRPSPTYKNVIKSIGLPKALSFRKICSRCGRARGEHSELGFGNKCVFDDCGKCHAGIQIHKQYGSPMGVLCCLSVKEGAIPEQVCRYARKIRDLSARAMLLKSLKQDKQEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIK8</accession>
    <name>A0AAD2JIK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="90" mass="9958" checksum="88A455AA75C2B03D" modified="2024-05-29" version="1">MQAILAETEMDQTAPLCTEAYAAFARYEAMEATSILEMTLWKGKLTSGWSNHDTTKRQALDRDSCRVVCGSDVILPRIVQFLDIPMGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIP2</accession>
    <name>A0AAD2JIP2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS14603</name>
        <name evidence="6" type="ORF">CYCCA115_LOCUS7081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000902">
        <property type="protein sequence ID" value="CAJ1940528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1954005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042440831" description="VWFD domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="248"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="566"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="850"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="877"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="918"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="970"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1018"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1940528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1954005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1352" mass="145910" checksum="95DA185C69DD4CDE" modified="2024-05-29" version="1">MVKLHLSLAAAFAAFTLTTAEKAPGDIIEMKMATTGQTDQIRILTKPRPGYTPAADAPSVWNMKDGCEDVSSVDFIFSPVDDESKCCKLESLDGFNLWPEQQGYTIPGGANIVAQEQFALDNGCFERNRGSGGSYTLQSGETYNSYMAQFLSHDQSTVFFDNVVEFHNQDIVAIIHDTDKLKESDQLFALGGQSTYKDVRDDEWRGFEANSHRYESLHVNCLARPSPGSCPVTLSTAVSEVAVSNESCEGRGWGDPHMVTFDGLRYDVHVKGELILVKSLDSAFEIQGRTEAVENHNARPAVTTGIVVNEVGDNPRIQVSLARDASDTYTEVLRASGCRGDHCNCPVQLFVDGVARPVSSGSGNTMASVAVTGGNRITIQYPETKVKVTMDVRNWRQTCHFSVTYTLADCRPNENIVGLVGSPDNEWRNDWMQRDGTPIPIPPSLKKGAGFEPTYIYTRDNWCVDKESDSYFEYEANTDFAFFDECDNPYDPSLEQAVANADAAVIEECQGDVFCIVDSIALGPEAAEAYLEDPALNHTLSQTASTDIEIVLQVPDESPDPNCPVCKARGWGDPHIITFDGVTYDVHVKGELTFLKSLSTDFAIQARTQIVANHPKGPAVTTAVVVHEDSTLGLPVVQVSLGKDEDSELATMIGPCAVQLFVDEEAKDIRLGTGSSDVTVQVKNKRIVVEYASTNLRLDMDVKVWRDTCHFSVNYFLADCRCDETLVGILGQPDGDSYNEWHDHTGNAVDIPSNGRKRRGIEAYNYSMTWCISEEDSHFTYESGMNHGTFDKCTSDNFDLDIDDLIENADTDTIDKCTIDGVLEEGCVLECEFLGDEACDEYIVIIQETETVEITDEPTSGPTPVPTSGPTRVPTSGPTPVPTSGPTPVPTPVPTSGPTPVPTSGPTPVPTSGPTPVPTLEGSSGPTVAASSSPTTLPTPGPTSGPTSGPTKEPTPVPTSGPTLVPTLEASSGPTVAASSSPTTLPTPGPTSGPTSGPTKEPTPVPTSGPTLVPTSEASSGPTVTASSSPTTLPTPGPTSEPTSGPTPVPTSGPTSVPTSAPTKQSQLGTAASDITTPETNVTNPDEILESDSGSRGDPHFKSWVGEHFEYHGQCDLVLAKDANFADGLGLDVQIRTKLVRFWSYIKRAAIRIGDDILEVEGSGDMSETDPLYWFNFVHQRPVQTVGGFPVQITKGTGRSHRHKFEIDLSSKYPGQKIVIATMKEFVQVDFVNASAKAFGNAVGMLGDFKTGKTYARDQTTVINDFIELGNEWQVLPQDNILFQDVSDPQFPKRCILPEDPRGDRRRRLEESTITMEEAEAACSKGLSDPLDIKDCVYDVLATQDMDMVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJS2</accession>
    <name>A0AAD2JJS2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001908">
        <property type="protein sequence ID" value="CAJ1956230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJS2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="293" mass="31705" checksum="DFADEEB41C2D99B3" modified="2024-05-29" version="1">MSPKCPDRLLPKIQWKNQDQYVDYGKKLNLNQIGATVPATAPAIVPGASSSTSGASSVAGSVNTPLRLAGTTGNQMMQVPSGMQLMQIPTQAGGTVTVPYSMNANCEIAFSGMQLGHQGFSGAQVRQGFDATQAQTPQIVKTGYFDTSNVFHNAIKGKDENGNDVYLIPCPAGTTKVKLQADWHYASEDEELPDLATEADRGLQFIQSRRKERDPFGLYDHVIMDSGCTNTTICNGELMHGLRHSEKELDMHTNVGSRVLEKEGFLGRFPPPVYHDEDGVANVLAMREMIAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJZ2</accession>
    <name>A0AAD2JJZ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001929">
        <property type="protein sequence ID" value="CAJ1956985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="86" mass="9230" checksum="4E78A4E07C00C14C" modified="2024-05-29" version="1">MVVLYPTIGFPDMFKFAPTTSYISCTLFKIHLLIKATPAQADKASAAAKEALKDSIAQDDCTDDETDAEGVATSNLGSFKPVTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKU2</accession>
    <name>A0AAD2JKU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylation factor-like protein 6-interacting protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS17572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARL6IP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKU2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019532">
        <property type="entry name" value="Nucl_RNA-splicing_assoc_SR-25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10500">
        <property type="entry name" value="SR-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1959149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="261" mass="30270" checksum="563710200655D969" modified="2024-05-29" version="1">MPSPSHPDNNEDVSQKPAVKRDDDDTSFERDARSRSRKSSSSHRRDDNKERKHNKKRRRHSKETRKRKRRKHYSSSSSDDDSSSPCSSSDDDSSSYHRRDRNRKKDRHKKRRKRSSSSSKRRRRDREGDSKDRSVVSDSKVKEWKEGNLEPMHAPSKVAAEVPPPVVDQQAPQKDDTPKRKAMMVPMSKAEYDKQQSQVRQVYDPETGRVRLVKGTGEIIESIVSRADHQRINQQATRGDGASFARSTLTVAAKQRNYYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLJ3</accession>
    <name>A0AAD2JLJ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002073">
        <property type="protein sequence ID" value="CAJ1960829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLJ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="90" mass="10220" checksum="4EA848433762AF13" modified="2024-05-29" version="1">MNITDFTVCKKSYRYLITQASYPNHDSKAVLDAFDPTKDLQLQDLNSLVKKGVQGGAPALYTGWPKEQVNNFNVWHCPMIRDTTVGEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMA4</accession>
    <name>A0AAD2JMA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF39">
        <property type="entry name" value="GLUTAMATE_PHENYLALANINE_LEUCINE_VALINE_L-TRYPTOPHAN DEHYDROGENASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="735"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1963275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1130" mass="126142" checksum="6045CC7A95578D74" modified="2024-05-29" version="1">MRQLLRAVPSTLWKRNHPTTGNTHSRLVLSSSLTTTPATTTTTPATTTCRWLSSSSDDDSNKNNNNNNNHNNNNNEKTMSAATIIPGSTGSAYGSLGDTYPQQLYNAPATAWQAERNADVQRVTQNAMIYELTQQQASTIQNVVPWFLEHMPASYFRQVPEQFRMDHIKAIASIRDANMDLYLNLKSHSHDGRVIYTFIRPGTQPGTLLSMVDELPFDEEKPLSRLHAFSALDDSMSLNMFVYGNKQFHEARPIDSPAMHDILELAAQVQAGTSSTNIAPNPIFEQDALLQYLQKCSDNYLNIISRMPTRFLQQRLLFEQVSGTEGCEVSIEDAAHEGKKHYWVDVAVANTIPQVALQHTCRLLYVQNFDVKRARLDVIDDGDNGSVTLLRLLVEQPDEAGMDTEHLCQEIKRSKWLDNTTMDLIFDTYPWLGVKRGEIITGMCSLMHSIFAKENPLVYSKGNIMEMMTHRRTIAHASKIADLFLDRFHPDETQRCSDDVALAARIQEIQTGIESDVENSVKIQLLNKMLDIVKHTYKTNVYMQNRYALGFRLDPSIMEPNPTEDKIYEEVPYGILFVHGRRFNGYHVRFRDIARGGMRLVTPATVEQYALESARQFDEAYGLAFAQQLKNKDIPEGGSKAVCLIDTNNLNLTAHSKNFVMRKSVKAFTDTVLDLVVDTEETRTNIVDYWGKKEVLYLGPDEQVIPEDINWIIQQAGRRGYATPAAFMSSKPKAGINHKEFGVTSEGVNVYLDVALRRTLGIDPTKDSFSVKLTGGPDGDVGGNEIKILIREYGECVKILGVADHSGCAEDPNGLDHAELVRLVDEVLPIANFNAKKLSEEGDLHLVDSEQGVKARNSMHNRIVADAFLPCGGRPNTIDISNYKQFLIPGTGKPSSRLIVEGANLFTTEAARKALYEDAGVVIVKDSSANKGGVITSSYEIISAMLLSEETFYANKKQIVEEVLSKLRNLAKLEAELLFREGDVYGAPLPEVSKIISNSINTATDALSAALDTLSEDDRDQLLPLFRAHLPKTIADLAFDEVEQKVPEQYIKNAIASSLASKMVYKEGTKFIDAQPKEKLASVALKYIRKEKEVALLMDSLRDVDMPDEKKQEILRLLDAGGARTALNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMH7</accession>
    <name>A0AAD2JMH7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="902"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1317" mass="146398" checksum="BBEB22AE76E67226" modified="2024-05-29" version="1">MSTAVATFGVDRAPSMKLHASNSSIEYRRKTSYRRARRTLNEKKEVRSSILASLDRQISYLEPEEPEQDIQPIPLVTEVPIEEATNTDIHTTNTTNTVVPFESVLSQQVFTPQSHRQTPPRQKQNKRISERSSRILESLDKHIGRDHEEEEEEVEEVLQVKSAPSTPKRPASSPKPSPSTLPKRKPKRISPKSKKLSRNPRKSSRMDDSSSRRSSMDSSKQSLGSRRSSMDNTIDTRRSSMDTSMDTRRSSMDSTKQSYSTTTTSTTIPQHLQPSSEDALASVWDGDDDDVAIGNLTPMKKASKNKNNGDSSPDVSPSSSMENDDEDNEDPTATPNTRKQKRKKKKKGTKRRGSNGGSSKRSLGSSSTTFSTIASTTTNGTRSQMESSFDKSLASTSIEMTIEEEPATASARALVEDSSKHRDGLTRILSKNKDVAIGNLMPGGGGGSKARHHHHHAAPPSPTSPDPSKRTSDNSLDSEDQFEHFYQEPIQRSSIVSTMDAANAAAAAAANISFDEEEEEEEEEHTDIDVDLLEASMSLSDIFGNLGDSSDVAIANLTPAKPPAKKEELTARPRASSVPKQRSQRMDEDDNEPTSSTGTPKSSKKKSRWSLRSQRSVDVDIEKEDQESSKKTSRWSIRSGRTVDVDVDTKADDASKKTSRWSIRSGRTVDADIDKRGSTRSHRTVDSWFNRGGGKEQQPQDDENSLNSQDLASEQRLAAIFGSQGPNSSIHNTPAASPIAIRAKLPPPPPPHRQPHRHEEWTDVSSPQAPNDDDSDEHLDQDIKSKLRLQAIFGEDHELAKSPEPQIRKQPRVERRGSFMSNRSTRSGRSADSKRKQSSFGSLHTRFTNRSGRSKERSIDNNSSVGSLHRSGRSKERSIDASLERQERRSSIGSVFSARSGRSRESSVDASFERQERRTSLGSLHSRMSMKSADSSVKKSKTTNRSKSPLRRFSPKRNRTPEKQRRVPEGTPNSSGGRPLDDDDLIVEGVLKRYNTEQCRTFEDHQEMAEAALISSITNTSPRELRRLKTKLVERLRAQLESRGYRNGEEDESVNDSDHLIEVYDNPQDDPSDVTSLTSLTSFTNFQGGASVKSGSIGALTKSSRTLDRPSNSALNYQHGNQDTELVFVTKVPISGGKYTGTVCPITSQPEGNGRMVYRGSKGVYNGEWKQGQWNGSGKHIKANGDYYDGNFLDNLYHGEGVFSYKESGRFFEGKYVMGERTKGTMRYADGSVYKGQFYHGRRHGRGSYTFKDGSRYKGDFYKDLMQGIGELRFRDGSSYVGEWKRGKHEGQGSMYSPDGVLCWAGMWQDGRQVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMR6</accession>
    <name>A0AAD2JMR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002211">
        <property type="protein sequence ID" value="CAJ1965634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="334"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="920" mass="102550" checksum="AB42BAE959DBA2BC" modified="2024-05-29" version="1">MPTRTANHTVTTNPNGNEEGNVTLPLGFVSSPPVVVRRANTSPAGLTLLSEISSITLPPSEEDEDDSNEICQRSNAPIDTLEELVDSDNDDALDRLETDDNSMGGEEDFQVLMIEAESAIEDRMYQLCIAGKPEGEEEDHCVSKKDVLMEMVDLTPEVKIPGIPPNWQPTEPRVANGEVPFDEVDNPGNWNEYIYRGKLNKSRQYKGHSLPSGAQPVPVSEGGKRTINGWEFHYGPWTPDDEGDDGPGSFRSGATTENMFPESRKGCLSVATLKLLGLTKSRMDGDDALFFYQLLYPICDPKRSGVAKDPREAYYFDVETFTRKYAASLEYGGSYGQTIKPVLAAELLKFHGIMVRDGVHGGSRGAVYRLWDPTCSCYDKDVVNALSLYRFRQIKRIIKLNDNAKSKPRGHELYDPAHKYDMAYRVVVANCNSLTLYAESDLCCDEMTWKFMGYGEGGVVRRIVGKPGVTKGGQVVMTSDASCCRPRAYVHRHTLHHRPTGFAKQGPNEVRMIVEKLDCLISKEDGDGKIFREKPHITLDNFFSGDETLDHLGELGFAATMTSRRDRLPAGVPKHHFHHEKGPVDDRSKAARFIHPITCVKKFPQDGEKKAYTRTHVSFQSTGSTNFSTVNAINSSRLYVVKKERGVGKEKRIWGVENNPARTLYLSHYGRIDTDDAMMAGTQIQYRSRKYWHSAMLHGLRLAIVTAYSFYLEASSGSLDASWKLVKPMTFHQFRDRLSTQMLQYKPRFNMYPGDSGFRSVTVLSKKARSKTHVVPSKRSRQTAVSVSTGGQHCVLIDELDNARKSKRLCGAFNHTELSKHLASFLEKGASISSGSKCAWCGEKAYQRCTICKVPLHNFPAKGMHKGKSCSVDWHNDSNFGLGYKDCKSLASKASVNWSLPSLAAKKANREHIDGLSGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN20</accession>
    <name>A0AAD2JN20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS21728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1966145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="133" mass="14898" checksum="B39205E0FFD7BCFB" modified="2024-05-29" version="1">MNSSSSAHQCSGLRLQRETEEAYIYVVDAPGMKSEHVQMTLEQTDRNATVIHLRDGRRKKEEESPSPNNGSKPPPRFHRLLSLRSNVDADRIDACVIDGVLSITVPKLSRQEQAAEPSNNICLQMTRRTAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNK0</accession>
    <name>A0AAD2JNK0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNK0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="987" mass="107953" checksum="72DBEB2A452EBDE9" modified="2024-05-29" version="1">MKRESTKIIVDTRITDKMPGLNDGWDDESDLNNISQDDTFNFDGDGWGDDDDIDLGDDDEVPPITAPVQQVPPIMGQFSAANNDRATVPSRFGNDDPAAASLGQPAVAAYRSNEALDPGADDNGWGDDDLNFDDDSTPVDAAIPSNHIDNNGQTGDGWGDDDFGFDEETPSTSELAGKPAQGQIEAGGNAGIEGDEDGWGDELDFDDDFEDKVENEKVASSSFNLPTQPRQNSIPPPPIKKKAAIPPPPKRPAILPPPKQTIIAPISSNAQEDGWSESNNSESDLLEFDDGFGNVPVPTANVAAGNKQVPSPSEQDGWEDDADVVADSKGPNKSFESGWGDDDDLFLDETSEMPNFPPQRPVANPRREELLRDLKGYVGSLNRMLSSVNAVLEYEYNTPQKAMELTEYYQTRANLAEYTRTKELSRMDYRVVLPNGDVVLDKQEIAANFMPDQSLAARCANQSLLADLLQVITDKDLLVRPQFMAICIAHDCKFTIHSRDETVEAAAQLHIALPQADGQRANIANIFATIAFIPQQPMVHFRVNAIDVLLPEHDFDKVLSSSVDFLMECQMDAFDLDGSHATPADVYRDAFMENSQKLLAQSTMGMKSALREMESVLNFKQKLTIVKRFIPDTDALLAAEQEAMEFAANRRIEQQNMPHPGSDQPGPTPPHIGSHEPRPPPPPPRRQPQLPGSRPQSILGGLVRSGLNKLANSVTLPDDDPAIYGQAAPVVPPVYRQDGSPFTHQGNQAQTNLLRGFPRPPSDAPPVHKSLQSHGTTSAQNPPASLSGRQQGGRQSEQLDLSRGFPRPIRQANSEPKKAPPPPPPPGRISEVDLSKGFPRPPPCPPPQQPKKAETEEVDLLKGFPRPSKPLSDQKVLGSGAVDLSKGFPRPQPPPPPSRPNQNQSSVAFGIVEDGWEDGSLDDDISNTSREHGKPTPNSESKESPLLTSRDYFAFDATNYVYDPETDIIPTIKRWKNLRPHRPYVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPF0</accession>
    <name>A0AAD2JPF0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS22931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1012"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1676"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1835"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1677"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1851"/>
            <end position="1860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1967779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1860" mass="207136" checksum="B90747DB24EBD398" modified="2024-05-29" version="1">MDEKEEMPPKSNNDDEEEEIVEHVEFVYDSEDKEITEEIKRTMTKLIVRGPNVKTIKEGVFKECAKLKEIDFTEATALETIGYGAFFKCPSLLAFKCPSNVKTIGQRAFLFCENLKEIDFTEATALETIGGWAFRKCPSLLAFKCPSNVKTIGDYAFCECENLKEIDFTEAIALETIGEFAFYKCPSLLAFKCPSNVKTIGRQAFAYCSKLKEIDFTKATALETIAAYAFGSCPSLLAFKCPSNVKTIGQKAFAKCENLEEIDFTKATGLETIGDSAFYECPSLLAFKCPSNVKTIGQGVFEECAKLKEIDFTEATALETIAAYAFGSCPSLLAFKCPSNVKTIGQYAFRQCAKLKEIDFTEATALETIGERAFCECPFLLAFKCPSNVKTIGVQAFAYCDNLEEIDFTKATALETIGDSAFRKCPSLLAFKCPSNVKTIGVQAFAYCDNLKEIDFTEATALETIEDGAFYKCPSLLAFKCPSNAKTIGESAFFKCERLKEIDFTEATALKTIAAYAFKICPSLLAFKCPSNVKTIGKNAFEECTKLKEIDFTEATALETIGEQAFYVCPGLLAFKCPSNVKTIGEEAFAVCENLKEIDFTKATALESIGYRAFYNCSSLLAFKCPSNVKTIGDKAFQLGKSLKEVDFTEATALETIGESSFGSCRSLLAFKCPSNVKTIEKEAFDLCKSLKEIDFTKATALETIGEQAFCFCASLLAFKCPSNVKTIGKEAFRECAKLKEIDFIEATALETIGEGPFYKCTSLETVYFAPNVTVVPKNILEECPNLQFLKIPSGNPAIHIRLYISLNEDQKNILLILNDIVNVYACNPIKNSELLEKLGDEKSILHQVRAMYIGSIVDGTRRFLSIPERNGWLQFLANNMGDGTDDPDMSKLLDYLETVDIKRVRELAETKDQSDRAAKSVASKHIQKVFEKRLFFLGRYDIARGPPIHQSATCVVVKATDAKMREYFEKKYEPYEGREVGKKLFQEILGKMELIPHDKENIKGLFQRADVKKDEKISKEEFVDFCLAEIGGTVVLKFMRNKDQFRREVNCRINNKLDSKYVVGSIRSHDKESDANLVESLKDSILQEDGNGTSSFLKKEGAKAEDYCNVLVMPYGERNLDTIFRSERLDILTIQTLMKEIGKAVAHLHKQGLIHGDLKMLNVIRINGHMVLIDMDASAKIGEDFAGEKYSSGVIPPEMIYQLANYKEKEKYVSYFQDQNKEEQQKRAPKFTTRSPKIGYAVKSFLGHDETTTFEDPETGNTVPKTKRMVTSKGNLPMFEVVGADSSFDVWSFGVLLYTLCSKHTLFQVNTDDDIFDGNSMRELYHWGQDDLEVESILENSIQDDAAKNLLKKILKRHPKDRPSMNEILLDPFFSGKTTDDVKEVVKEEFGKMKSLVLENRQIMQHGFSKIHESLNRLKSYQETANALLKGIVQGKKAQPKFLVILPAAEQDNHQEKQFSRFLSTLSKIKNASSLTTKARLCFICPISLQPVVGTDGKAIGYDIKLAKDWIKKYGPAILIGLKIVQVGLAVGRGFGLPLPSLSGAEEGLLETSDLFAEIQGLLVDGMGGDAEEDGLADMMLEKFADRVDSAASAEGPVTMKKNHLASIQKSYDGIGLLIDDEEFKRCGLVQAVSSDGKEYEYVHPNVKPLFEKFGSKCLEMSMEERETENAMLAAEAREDGDKDTKKGSPKNGHGEMRKHETAVPVPVPVPVLVAPSDSIPQSELQGIPQGSINHVVHKGWLRIQSRWPPYLWKQRYVVVYNNCSITQYPNAGSTYLDAKWIDTNDGTMELRSGGKVVAKAKLSKRCTSSTIAEWCQGNNMILNSDEQSTPDLKNRKAAAASFRGDHTGNVIQSNNNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPM1</accession>
    <name>A0AAD2JPM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002473">
        <property type="protein sequence ID" value="CAJ1970180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="453"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="584" mass="67343" checksum="44DEB7468390CFF4" modified="2024-05-29" version="1">MALIQEVLQRLQAAGLKINRLKCEWCVQETDFLGHWLTPEGVKPWKKKIDAILKMSAELCYLLPPHSNMWPRRSHLLKPLTELTGKGMFEWTDECAKAFAEMKALMASDIMMRYPNPNKPFEIYTDASDYQMGAVIMQEGKPVAYWSCKLNAAQRNYLVMEKEMLAVVHCLKEFRSMIYGAKLTIFTDHKILTMRTLNTQRVLRWRMFVEEFGPNFVYLPGKDNAIADCFSRLPRMEKPSEGKSPNKGKLIAFDKLQVSVDPEDKIYTFEDNVLVKENDLITPPTEAKFNSTFRCQFSCCQDGDIHEHLTIDDIEIEESFLNHPPLQTMPNPITMPNIQQHQTQDQLLMQQAQRDAQHYQIMTIDERLIITYQIDPACQDDWRIYLPLSLVDDVITWYHLVLGHRGKTSMYAAIAKRFYSPGLKQRIERFNCEICQLNKAANVQYGQLPERHADLVPWFSVAVDLIGPWKIDVNGRELEFNALTCIDPVTNLTELAFIKNKTATHIASVFEMLWLSRYPRPYKCIHDQGGKFIGEAFQAKLATWGIHDGGTTSKNATANAIFERMHLTVANILRTRYNDAAPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU61</accession>
    <name>A0AAD2PU61_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="576" mass="62368" checksum="78DF25B6031DE66D" modified="2024-05-29" version="1">MSEPEDSTRKKGRTKVSAASAGSRGDATTIKKSTGTRSSTSSSTPSTAPSTSSSSTSSDNSRRGSKRSNEDPAQEGSQPKNQLNLLASVSMGRKVNGAEQGGSDSGVSDEQDSQDIPKRTLHQERESTLSGQKQLQQIPNVAAAPPENQMARRTSDEKDTQDVPNEPQHQDREAAQSSSQQPLQQTTPNVAGLPPEVEQMAHRIILEALQIIMNQPSDSSQPPHMMLIRQLAQHLANAGNTIVPPQPFETRLSGRSAAEMYLAQLSRNGNYQNSAVALNSIQQLQQLMMQQQYPGSTSNPPSYNPFANVAALLQQQNQLQLQNQLSSLLAMSQYTNPGLLSAAAAAQDPRPASNISIAAAAQNLVNPLAAMLNHPGVAADGTTATSATTSTTGSVLPASAASASAVAGESQQQQQRRDRINFIFEPTGRPSLPLATDSDEANLAPYQCLLRQQIELFETREDDIYLKAQGRNTPIRVGQVGIRCRHCAAMGRSKRVEGSAVLYSKSLNGIYQVALNMGRLHFLNNSCPMIPESTKKKLNELKELPRKVARGRQYWKENLEAQGVLEEQEYLRFKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUP4</accession>
    <name>A0AAD2PUP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUP4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.606.10">
        <property type="entry name" value="Vanadium-containing Chloroperoxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016119">
        <property type="entry name" value="Br/Cl_peroxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052559">
        <property type="entry name" value="V-haloperoxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34599">
        <property type="entry name" value="PEROXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34599:SF1">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041934645" description="Subtilisin" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1066" mass="114712" checksum="7F7B9C55B49F43A0" modified="2024-05-29" version="1">MKVSFTMSLSKSLLLLCWIFSVALAQSACTCNNVDENVRSFNENSTEQVFSNLATEIAFIGGYLIPGTLGEPHKMGMLQSVMYEAYAANGANDWAPLTEAGMIRKQVVNTTDEDEIAQFVAHTAYGCIRRLISGADEKIALLDTKMQSLGFNSPSTDILMHESAPLVMGVLQKFMPGPSPDINIINAPSNTSVNACEGLVNAARWQALCVHDPQHPAECKTQDLSFGPLYDARLIVADGERQINDLIAQAAIPGAELDSSSEEFIAQHRAVLEASAHLDDLAKFQAEHFQPNAVALAHSMILEEIEARGLSLEESILVLFGTIGAARDAVAGSVTIKLNNQSVRPITVAQCQFRGVHILGWNKPYMGVRNMTNNEGDLWTPYLPTPPHPSYTSGHAGAAGAAMAALKRFFPDGLIQGANCATRKAGTSRYEPKIEAGQPGYIANVTDVPNQGPGTVGYSPAQDVTICTASFDDYAEQIAESRLLGGIHVPMDNHYGLQWGRYMGNHFYETRVVPLLPADEPEEEEPATCSCNNDLDSNARQFNESSTEPVYSNLATEAAFIGTYLIPGTLGEPHKLGMLQSVMYEAYAANGANDWSPLTEAGMIRKKLITTTDEDEIAKFVGHAAFGCIRRLISGADEKIALLDAKMKSLGFNSADILTHESAALVMGVLQKFMPGPSPDFNLINTPSNTSLTNCDGLVDGSRWQPLCVYDPQYPGKCKAQELNFGPLYDARLIVANGGRQIKNLIQASDVGSAILDDSSEEFISQHRSVMAASAQLDDMAKFQAEHFQRNAVVLAHKVILDEVEARGLSLEDSVLVLFGTIGAARDAVAGSVTMKLDSQSVRPITVAQCHFHGEETMAWNKPYMGVHNITNSEGDLWRSYLPTPAHPAYTSGHAAAAGAAMAALKRFFPDGLIQGANCARRKAGTSTYEPKIEAGQPGYISGVTDVPNQGPRTIGYSPAADVIICTATFDDYVNKVAASQVLGGVHIPMDDVNGQKFGEFMGNHFYNIRIAPIFATPSPSATATALPTRASPPTSAPGSRSFSAAFERGVWGVVTFALTMGWSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW48</accession>
    <name>A0AAD2PW48_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW48"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041938686" evidence="2">
        <location>
            <begin position="22"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="336" mass="37159" checksum="78594930BFCDC112" modified="2024-05-29" version="1">MISRIPFYLFVANFLCQQAVGFQAVNMNGASSSLPRPSASTVGTSPSSSTTSLNYVNAQTIDSTVTETDSFRNSILNTYQREEPQVSISQLLTEQVAREFTAGRRYLLAASAVKDLSEEFYDVEEQQRVRAMELMEYARAHDIEIMDYASQVDKTPIDKSMKTTELLQELLVQEQKDVKRLEKVMSQVSSKNVKLLAFLEVIRADQMERKDQIMQTLADALPNMQQTAVDTAASVATGDFSLNFGQELLNKLENQLQGMGQHVQDLVSKSTSGHHFTFTGATVATVAAVDAVDPESLPTPEDILQAVDTATALFDQQNLMDTETLTQLVDIVSGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY52</accession>
    <name>A0AAD2PY52_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002461">
        <property type="protein sequence ID" value="CAJ1970103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY52"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="212" mass="24558" checksum="A584447E7B97B5F0" modified="2024-05-29" version="1">MPGGRHQGRSGRGGHGRRSIQQTGRGSQGKKTERKKQYHPHNPEYTHGQVTVYLLEAIALKGLDYAQDAIASVQNMAHVDFDALRGSQTVSKPEKNDTEFHKNSRQAQLDRNWENLNNKIDKREVIYNTNKYTVAAIITKHFITSAMRDKLSNETDWIDLQEDHVKLLKRMQTFMTVTDETKWQHFGLMESLKRFTNFTQKHIYITDALIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CA43</accession>
    <name>A0AAD2CA43_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1894733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CA43"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042173001" description="SEA domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1894733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34737" checksum="ACF157D8675428D3" modified="2024-05-29" version="1">MVQRLTALLSLGAMIMTNVHADNMDVASRELTRHTTGNAPEELNVNAKDTFNPNFMKDMFSSCRPEKDGYFGSTYGEPVRLTYGFRIETKPLSSIVDMIDLVEDRIVDNVLSQSFPNLCGFGGRRLNKGRASGFRFLKLVGKDECSPTVSGFDFCAVFSGQVNLYGANSAQASANVYEMIREALTPEEASMIHTDIVAIRIDDGQFGLTGNIDGEEDSNANTIGYICFGIAAVIFGIIFYWKCIYNKKEMDTGTNNRGLYNGDNIMPSYDDDVSEFGKLNTGSYERPIAVGFSDAGSVYSDYKDEYQMEDPDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBM0</accession>
    <name>A0AAD2CBM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS1107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="4">
        <location>
            <begin position="495"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1924843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="579" mass="64116" checksum="AC0B96A5D2BD2C0B" modified="2024-05-29" version="1">MSKEVTLPQSIGLVDCNFDTIAQILSFCDILDVYHLLSSSKRDWEQPISTFFSAQKAVSFSCLLKIFRNKIGNGDDEQHNAVIRLVTLLQEKNLLKHVEFSGMRQLSGSTWLPQLQNRCKLQTLDLSGCASLDPDTLETFLNGCPTSLRGLSLKGCIRVGASVVGVIRDCHQELESLSLGGCSISIDNSAIYRMFFKLSKLKDLDLQALKRLKDPILFQLPASIQSINLSSCEGLRLRGTSTDRMMLLHLQDPPISWENAPISRHKVRHLVLDAIGTPRRGLLPGALTYFALGRQLREVHLSGCEHIRDLEIQVLAEVCRGTLTVVQMRACRIGNAALVALGTHCTCLTECDFSACFQVSDEGVIALCRNKRLVHDRSNPKRLCHRSTLKSLKIASLPLLSGTAVSEIASLDSLLVLDIRDCPKVDASALFGTVLQLRQLIDLNARGINNSPHSIGQMIRQKSANIPPSLRFVDQRVLSFDPPRSGRAISSFCCTVRTHSQRLNSTVPMQYMYHCVDCGLSQSVNRGICSNCVTTCHKNHRTYLGSFTRFYCDCPFSIEDDGTANSGSVMQTCRAIFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBX6</accession>
    <name>A0AAD2CBX6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS1090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="588"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="847"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1924550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="910" mass="101649" checksum="AFF910ED9F4A723A" modified="2024-05-29" version="1">MVSQSVETRRLQTDTIETSDGDDSDTSCCATCSSAPQQYVRIATWPTAAETLKSYANMYNSLHKDALKILVDTIPSIRDLQDSIELTKTSLAIDSHPRVDGYVVPPMLLGTLSEELASLDFATENYLPIYEHLTTVDGTTAAIPLFAGNQLLLFYKKDLLEANELGDEAPPNTWDELTEFAKKLDGDGSVTGLCLGRMSEHACRQRSSITGMPCHSQSMSYWSMVLASLAQSAGASSGWLFNVKLNGKIVPLLNQTLQPALNIIEEQLQYGGADALESDSLDNLKGFRQGACAMTILGHHPLDLLKDPNVGVALLPGSSMVLDRPAAALRECTYRSCPHGRVNPNKQGEGVNRAPIGALDIAMGTILDASNHKGELKEFFDFVEEHRSLNDEMGGGRQPLTYDELRALTEIDPDLQAYAGLIETTTSDPNVAWPLTIPGSFDLLSELDQQVYNYLVQDNHTADASKDLVRKVDRAWGIRMQQQDSRVHATPLSILYQRSLQGVVTEEKIDLYIGIGFRLVCWAMGGFACLLSIAFAIWVYVNLDQRVVKASQPLFLWLVCAGAFIMASSIFPFGIEDDIVSYRGASISCMSSMWLYALGFVMMVSALYSKIWRINRIFRYAHKIRQIRIEKKHIMVPFGFLFSINFLLLVIWTIVDPYEWIREEANPGFTNGFCNSDHYWAFIAMLVFANLLVACYTLIQAFECRKLSTEYGESNWIGFSLAFIVQVWLIGLPILQLTGTTPDWLFLTKTCIVFFSCVSTLLCVFIPKIQYLRDEATKEDNERQLSGSGRTSMFGAVVKPFQSGFGMIRMGSQYMISRSSQHNTSENMEKRKNRTSGVIGIRIVRASGEYAQDMEKLQKNLKTAESRRRMLQDQLEGLQEQFEQYIISHHPHGAHVGAHMDALANSERTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD70</accession>
    <name>A0AAD2CD70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4126 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS1953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD70"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4126" evidence="3">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1930476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="274" mass="30137" checksum="DA33DC28D0EE933A" modified="2024-05-29" version="1">MSEIFDKLVAYCISTVLSGSSGVTSFYTLFLMGCIERYDPDLLSMGDTMDKILASMPALIVLGFLAFLEFLAMCIPVVDELVDGCMTLVVPFISIISTLGTWGLYLPDELNEAAVIFNGDTGNNSTRMLEEETFGGDLKQGVGFAQIFALVTGVCVALAVHLIKMLVRLFGEGWLTNILAVLEIIIVTFSIIVVVFIQYVAILFAACLLASMLWYFTKGRREAAKKKKEQEEAKNQQQQQQRAVPEAVPEANQQEVIQEANPPPFNPEVKDAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEA0</accession>
    <name>A0AAD2CEA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1926603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="123" mass="13728" checksum="6694F19D95B4D5EC" modified="2024-05-29" version="1">MQPPSKTDIPHGTYPNNVDAPRPSPILQQRLLGHLQNLTVDTRGRDSHEDDETAGASRSSMMLLSWIEQTSLSVGFLSPMSLPIAQHRKRPMDFVKEAIAVINSAKDDEDDDDDDNDHHEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEB2</accession>
    <name>A0AAD2CEB2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1906993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEB2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041917435" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="183"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="662"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="816"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="671"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1906993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="895" mass="97239" checksum="2F339CD93237D613" modified="2024-05-29" version="1">MMIVILRSLRLAIASVCLLAVVADQAYNDRPSFSEFEVELCDMPCQNNGNCVAFDLDNDGVLDPQCLCNTTFQGDLCETPRSCSLACENGGTCSLGDAWWLMGEDGSLGFIKEILYGCSFEGVRCEFPPPGMDERCDCSFGTNGPLCENTCDVACENGGECIFAGSEQRCRCAENFYGDQCENVCSKSCLNDGFCLGYPSSEAAGGFEEQCLCRAGFEGEQCETVTPCSISCQNEGVCKFSEQLLFQENGEDGFIVEYWQSIMERCIFRGLPISECFRLQQEEVAPYCDCPPTTFGNTCEITCDLDCQNGSTCQFHNAQNQFCSCETGFAGDLCQFECTMGCVNGGCNANATAQWCQCSPFYDGDFCETERTCDKTCFNDGKCEFDEGFRVYSEMYYKTCIHQSFSNCPGPDDIQRCACAKDFVGSECSQPCPCQNEGRCITRYYSRKLEDIEGGNYYNNGDDQPYFEDNIDDEFGGDGEDYYCQCPFGYGGRDCQLKMGSDNCDFNCENGGYCRDYAFNDCVCPEGFTGRSCETEIDACNNQCKNGGVCTTDAISTQGLGNRALQGTTPTFAPTSAPIIPRLFSGSCSCPEGYSGDFCERKACGSGYCSHGGSCIELPSGQTTSAGDNYVCDCSTSTLEETVGIGRNCDAIVYSTCPIRSNVNPNEAWSCAGYGKCFKEGQDSIPQCSCDTTFTGPRCEFDINDPKDVAWSECSLECSNGGVCLKGATKPIADIFIPFTEGTKKSGLFDYQTRPDFEYCYCPDGFFGVQCDKQYDICGNREHICFHGSKCENDGGAWGCDCRGTESAGLYCQYKATDDCGDSNLDTFCTNEATCTFDFSSDALCTCVEGWEGTKCETEVKLAAPSGGEGDYSSAPTLAGTLLSVLSVALLSAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CER0</accession>
    <name>A0AAD2CER0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000153">
        <property type="protein sequence ID" value="CAJ1931489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CER0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="400" mass="44692" checksum="CD854F9BFCB4CE14" modified="2024-05-29" version="1">MKTKVIAGFPNDAVDKVEIHKGVRKIFDPEYEDSEEEDAPIGDKDNGLVNRYAQPDGWDSDETGDDSEFDNKTDDDADDDDDDASEESVIIVESTRPTDNEFGGSRSGRGRHAETRTITDETVSELTGNTGDESEPELASPPRKKGRSQRVSIDEQATAMDVDGTDPSVGSRPSGKRLHPSPRSTKPATQEPAKSRPTTNVPGAKRKSQRTLTLEERLDDLRNVDLDGMEGRAMLVELGMVYNYPGQQEGNQSHASIILKHILDTLSDTLRNTEETLRILPLSDRTYKNMQMWIRNEADLRRLIPDYRGLSRYLDMSFGNMSYASTSNKPGEKKLRTRLRVGFEADVSSEMIQQYLHGELQHQGRGAGCYSSVLQFGDIEKIGALCFYPQEINIKAIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CES8</accession>
    <name>A0AAD2CES8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1914367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CES8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12531">
        <property type="entry name" value="RRM3_MEI2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034454">
        <property type="entry name" value="MEI2-like_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="675"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1914367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="808" mass="88266" checksum="972804E7A0868733" modified="2024-05-29" version="1">MASAGSINDRNSGDGAWDGGASVPSLHSGLPNDRNGLGESQHTTLGGSLSTPSFGAPPPGFNPGNDAPRSNLMWSNKEPPNIRDEGMDGHRSSSFNNLAAVFGSGLAESINDAVLTDSFFSPDKKQGDLNYARQSRQTALRMGRGGDSIGSAHKTQEAGNLFASYDAPNNRATGVRGPAGRDDYPRGQDRSVGGLYPDHGYGTAFAKDRNAAHQQGGYDLGMTVTEPQDSRSRNRPDDGTMDLQRGMKNLWSSDEQPPKIGGAPKDARIMQQEAEDDLRPFAWDIRHHEPSRALVIMRASTLAAADARAACELFGVVEAFRSDFADRGIFFVSYYDMRCAQYAAMELLPKLQRPGVDGDKILVQFCVPLNSSSQFDDSLVVLNDVPMDMNIESLAQMLSSYGAVRSLRSLGGNYGGTSFVAEYHDLQDAKQAVLELESTQPWGPNVSVEIGARNPSDRKRGRELLALIGRWRHGESPSDSNRRLPTSHGGGRGGATYGGHHDLRGTAYIPGSHAPRHDIRYDRGGAPGRGYGQSYGAVMNNSGYPQSYGNSMPPYQADHRSNHHGSYMNHGGPPSHQHYGGPPSHGRGYHFSSGGSVVSANSAYSDGHHSHHSHHSGHYPPTSSRSVPYFPDGASVGSQSRDYRSVPGGGTPDQKDNRHLKLDVDAVENGRDSRTSLMVRNIPNKYTQQMLLSEFAENGHGPGTIDFFYLPIDFKNKCNRGYAFINFVDFRDILPFHRRYYGKHWRTFNSDKICEITYARIQGKSAMLKRFENSALMEKDEEYKPLVFVSSGPDRGNSLPFPDPSNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFC0</accession>
    <name>A0AAD2CFC0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000215">
        <property type="protein sequence ID" value="CAJ1932246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1932246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="158" mass="18236" checksum="5B811FAC7E104046" modified="2024-05-29" version="1">MMLGIEVTPEQVLIYGFEIIGDSPTTITDDDFKEHNIGVFKAHFGQRPTGQRPSTLCILWQDILNCMNKDLGLRASDRSKEGLKRLLVAIHSLASATGICTQRDQDDNLWHWVKVLWALEANVISWSEKEYKQKNYGPRKFILNKLDPYLFTHLHCDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGD6</accession>
    <name>A0AAD2CGD6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1903756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGD6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1903756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="170" mass="18999" checksum="86ACCA907D4CAF6D" modified="2024-05-29" version="1">MSRSTGETDITLTIIRTADAKKLEVVLPLSTTLGELKEDLGGADLFGPLPEDHQRLFFLGRELKSNHRSLQKLGLDRFPKNRVLHLHAKQQGAASTTTTSSTSATSKRQRKTNTRPRSTRSSTQQQQQQQQQKVTVTQTSAGNAVLEIHDDSDVEIVIDESPRDKRRRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGT6</accession>
    <name>A0AAD2CGT6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1930257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="216" mass="22909" checksum="8EEA4EC85B2215DA" modified="2024-05-29" version="1">MSLPDDASHSKEEEHEVSELNIDAEMIMESIVRVSFAGLGGSLVGLGQKRRLETMRVLTGAAATAAARRRRSPMTSQLNMPWTMALSCMAFCGVVETCRLTSPSSIVLQSLESRKMEPFGKSEASRSAAITISDFTIGGAVAGIAGSFGKTSQKRIPVAALRGSGRFFGFGPGLALGMIAGAFQAAADYSINYLEMTAALEKETLAKPQVSEENVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGU4</accession>
    <name>A0AAD2CGU4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000191">
        <property type="protein sequence ID" value="CAJ1931908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1931908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="763" mass="81905" checksum="999A7E48563B3248" modified="2024-05-29" version="1">MASPSSIPPTKKQRGGSTPVSRNLPRGGRKTDVGIEADDAIARRRAELRRLAEQRNKKAASSSTARGRPAASASSNSRPPITSAADLMKPSANLTKTTRSRSAGRAPPPPPVARKLEFNNSSGKAVAVAPTMPAPGNISRAKSVPPRRPAAPPARAGSTKRGGGGAAAAADNRSQQLPPRRPAPVDPTTLLAKNTTTATTTTAAVTESSLSSKPTQQSLPPTTTTDSEPPLMVEEEEITSSSSKPFAAKTPATSAKMMPMEATPSMPTTTTTTEPSSTTSRRDRMKQLRDGLESPKTTASNKPTATTVEPSTTTTAATVNPLGSASNDRLEEELKKTEVERNEAFQKIKELEDKLTDISKSTILQQKQQKQQTPVQDMASLQEIMELYKKEGEEAAMQYAQSKLASTKQQAGFLTPMPSTPLSKSLSTVSQRVATPYPNRGIAAKGKAQPTDEDLERRFIHSFREAVNFVPHEFYGKVAIQGQSCVFFVRRPYGLREQNGIFELVSPTVLDAYAKRAHVGDPTTIEVAVGIPFDDSVLCLSGSMGVRYRITPTGAFESKPFVKEPLGSISFIDESANEQEYSLDQILQEALSVREQYCASMMTTALGFERRKPLPAAATEDGASVAASAAPKPEVADVAVDTSDMPIPKEIALDKTNKKEEKKPKESKPKPSDPEELPGAGDVLISFMGIVIKNIFGFIWWIFIGLPITTIRASIAITFAGVIVGMLYLYALQYHHEALLGGGNSFYYSSSASYHTNIAPGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHZ2</accession>
    <name>A0AAD2CHZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase sigma-70 region 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS1350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000025">
        <property type="protein sequence ID" value="CAJ1927774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050239">
        <property type="entry name" value="Sigma-70_RNA_pol_init_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30603">
        <property type="entry name" value="RNA POLYMERASE SIGMA FACTOR RPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30603:SF47">
        <property type="entry name" value="RNA POLYMERASE SIGMA FACTOR SIGD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="Sigma2 domain of RNA polymerase sigma factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="Sigma3 and sigma4 domains of RNA polymerase sigma factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042042849" description="RNA polymerase sigma-70 region 2 domain-containing protein" evidence="7">
        <location>
            <begin position="30"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase sigma-70 region 2" evidence="8">
        <location>
            <begin position="288"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1927774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="568" mass="62781" checksum="8D37C5EF2C3E7BB4" modified="2024-05-29" version="1">MKQTTRINSRAHSSAYALVCCLAVSTCNAFQASQPATALGSVSSSSTARTTALHAASRREAAPAEGKTESKKGARKWSGSRVKVNASANANESTAASTIGTRRMKKKSHPNDYLMMTDALMHDLLTREEERELGMKIRRASKAMAKVTKFAEMKQLRLQESNMEQEAYSNEFISEMQIDQYPSLGLDEEDIEGLSIFGVHCNRLEEMDARSLSGMDDDIEGWNFQRLRETDFDILGIDQSSSFQPNSSPLSIDKILTEEDVVAELNIAGGRDELARIILDGALAKEKLISSNIRLVLSIAKTWCQRSTAVSGNAQYAGGWDRPSLEEAIQEGILGLSIAADRFEPERNLKFATYATWWVTNSVRSCFNTAKEVGLRVPVYYHAYRQKYQAFVKQQYDLTGEGVTLEDAAKELDLTPKRLAFILQSTTSPISINAPPNQFQKVSMPGKAGGEEASNDLLGMAANLKSPEPSLEDQIEISLLRQCLENAMATELSPHERDILRLRHGLDDGVSRTAREVAEICGGSVSLTDIRNVEMRACRKLRSPYSVHTARLHDFLDFVGADMTTAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI27</accession>
    <name>A0AAD2CI27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000420">
        <property type="protein sequence ID" value="CAJ1934931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="580" mass="64480" checksum="C58255F990D80815" modified="2024-05-29" version="1">MEAIPDSTESTVNAASTRSSSRRVREFKNWIVTEENESKSSEFASGHETIQSISNSTEHPIQDNKQGVNSNRQEDTKSAANRKIMGYKQATKKRLRVDAAASLLATLNERAYSRSLLRDANSINHRIVLPMGLPWMHDTVPLSKTIPFDIDEMPDILAAGEGRDMPFAHTPSSMNKKERKSKYAFARNSASLHSVARRCSDPGIIDLTSIINYEDENNLHYRFKGNSASFRSIKSLPGEIALLSFEIAHRRKSTVQDHAKTISRKKEWSVRINSTSSKSSILPSDLAGYLEARLPAEVQDGRFLSMKRAKAIAKALGSYDCRHGLPPTNPTGKNANRITVGRTRRMWTAKSPPGKPQRVFFTSLLTGEKLDSGSQKRPRDVRLAIKVEGEYCYGENSSQYSPLSATHFWGMRTKKRCVVNPNNYASILLKHGNIREKDVLSDQERSEGEGESGFREPQFDCLPDNTGVICVTCTSPGNITIPSIHDILNNSARQNSLHCTVCWAPRSSQLGEVQTCAVCGLSAHLQCCLDPGEVSHIAKGGTISGKWMCAVCCLRRQQCANDTKMCPLPIFWRSYVSCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CID1</accession>
    <name>A0AAD2CID1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000080">
        <property type="protein sequence ID" value="CAJ1929451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CID1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="173" mass="19443" checksum="A28A4621AD25F725" modified="2024-05-29" version="1">MIAAQNGLDLQCADIQNAFLTAPAIKKCYMVVAGPEFGDKEGKVFIVRRALYGLKESSAAFRSHLAETLEELGFWSSTADPDVWMRAAVKPDGEKYYEYILCYDDDILCMSMKAKEVMKGIGRVFKFKKGKIEPPESYLGASLRKKYLDGVDMWTMSSYDYVVVAVLEEDATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ73</accession>
    <name>A0AAD2CJ73_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18352</name>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3241</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000258">
        <property type="protein sequence ID" value="CAJ1933286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002035">
        <property type="protein sequence ID" value="CAJ1959935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ73"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="333" mass="37935" checksum="2027215B4E494CC0" modified="2024-05-29" version="1">MFRKYTSYSQALGDIHHPVAYTASEDFPLSDIIPWDVRSKAAGGKDCLEYFVHHNYGDGFGHQLSDIAAAMVYHLLNRNQMCFLGIVYYDGDHHQFDHGCKSCPAIYNTLSRQWPGIDPNFSNKTIHMFDSTRLWRGVARAGGEKRYSYVPCRSCDEARMTVARIWVDVVKKITAKKKIPTLDVAIHIRKGDFPRPISKTYAKVIDEVFGNNVALDIFTENSNEASDFLMQLNRSKEIRVHEGGDAADVWLTLAKARVLFVHESSFSISASIASEGIIFSQNQKPYEGRYDNHHFPCKLNDGWWVSTGLHGNITCDVEKMFDVFRSIEDKYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJE6</accession>
    <name>A0AAD2CJE6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000513">
        <property type="protein sequence ID" value="CAJ1935797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJE6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="137" mass="15453" checksum="DE4D12F66F2AF6E9" modified="2024-05-29" version="1">MEVFVDDFVGMGQDHPSNPLTNQRAVLSHNIDKVFRPNRPTDNQWQKEPQSQSKVAKGDASWHTVKEALGWNWGATTKTLQLKEKRVSKALSLLGEVLDCKRISLKRWQQVLGVFRSLQPGMSGSEGHFSLLQDALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJL8</accession>
    <name>A0AAD2CJL8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000532">
        <property type="protein sequence ID" value="CAJ1935962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJL8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="114" mass="12731" checksum="0A9E811690C5170D" modified="2024-05-29" version="1" fragment="single">NFVTSPDISSPRILVLRSTRIGTKKKNRVHPPAWCRGTSAAVLLEGKDKIIPRWEKGLLVLLKTKKKELTNDGATTEAEPPRKASMTQMSTCLKIGCPCRHLFPSRAPRIKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKR6</accession>
    <name>A0AAD2CKR6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000591">
        <property type="protein sequence ID" value="CAJ1937043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="141" mass="15778" checksum="2EC654531A921C6A" modified="2024-05-29" version="1">MLSQKEKGLSQKHAKDLLASAIYCSFCERSTKNHCDLEKQVLPMSLAMHGGDDVGPNGWICLRKLQMLVEAAVMWCSKSVAAPSSVAWCSYILRLSVGENEHQMLLVTGRIEWWLLQVDADASSVGFRFMLHSTSTFQLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKW2</accession>
    <name>A0AAD2CKW2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="318"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1937934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="754" mass="83699" checksum="3A4F02122BE9D95B" modified="2024-05-29" version="1">MDSDDGDAFGSNGFQMMGMMNALKTGDMHTDMIIAMCVPFVLRILFSWIGKLEEIPNWEIWVKWWQADGIKHERFISHSTTRNSWGGTYDTDEDTKNSVLLKAIKMYLDQVVKLKLSAAHLDLTQLKETSGYYYDDSDGDDEDGEYQGSRKTLVGMLSRYKIINRIPDNEWHSLGFFGDPASKVLLRIEKQTRNEGDSEEKNKTKFEINETVFHFTADEEGSIDAFINGAYKWYIGELRKMEDNSRYLYEMKVQDRKTGMSDDDGGGDSTNGTNYKRYKLSDEKSFDSLFFKEKKNLLGLIDHFTNKTGKYAIKGYPHKLGVLLHGPPGTGKTSLIKALAQYTGRSIVNVPLTKVSTNSELMSIFFDRNYHVEGASVPVKMTFKDVIFVMEDVDAASKIVKRRDGRKTSNMLDDGQQIPLPTPKSLWRMFLESTSDDCKALVKELTSKSDRLKEDEESQRSDVLRSMNQRLAGLPALGLVGEGVAVQDESSPATQLCDNALESASKLQSRYSKLNDILSAHAKSIKSLLESGTNVDDDFINDLLGEVGSLTVPTSDSSTCSSSAASDESPIPAQAAEEAFPSILDLDGLSDKKGSKSSGFGPSLFKPNPDALSLSGLLNVLDGVVDTPGRIVIMTTNHPEMLDPALIRPGRVDKKLLLGRMRAADVICMLEHYFQTQLDNSQVMLVEAAINGESSSGVPMLKLTPAQVEQMAAEHDELDSMIAAIEKMNPALVKKSREPFSAVSKTSFDKTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNA3</accession>
    <name>A0AAD2CNA3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000636">
        <property type="protein sequence ID" value="CAJ1937384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNA3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="185" mass="20792" checksum="D938A9B8AA347272" modified="2024-05-29" version="1">MAVNDFTSKATEPEICFPRSFPNFLIWIYNLRITYPKEEIYICDDDVSGAFRHVKWNPNVVGMHMFMLFGFLFFCMGLSFGDNTSPAQWEVVAMVRQQLAQSLWYAAVTTIPRVAKYLPKLSFAPLPTPSDIATFTPAKPDSKNPGVVNADGSRKSPTFDHHVDNCPYADVALFLRQTISASILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CND0</accession>
    <name>A0AAD2CND0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS2042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CND0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31652">
        <property type="entry name" value="LIMR FAMILY PROTEIN DDB_G0283707-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31652:SF0">
        <property type="entry name" value="LIMR FAMILY PROTEIN DDB_G0283707-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1930697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="539" mass="60730" checksum="CAA1FBFC3D0C95C0" modified="2024-05-29" version="1">MADIFMIIVAIVAFVILAVVAIYLMINYQHPDDKNEAYFPKFIVIVGIMLAGFTAFLLPMDVANNDGYAGCTGYDTDLCGGLDMELVWSIFFWLIPIWCFVLIPFATFFYEADDGLLLNPGGEKQSRVKSAVVWTLGTIIIVGIIFVTTYFLFSEAQIPIKAYTAKTVAQGLTEQERGRIDFQSTVPAGVNFTTSFLADFDEGDRLYASGQVDLGEQTIPLKVSATTFFAGLMAWLGWFLFAIFGGIGMSALPMDLLLSFRNRPRKMDAAEYAEAQTSLRTRVNELVGIGEMIKVERDGQAPTNTSKNPFNKEKRKERQALNEFKSAVFLLEQDVQDFQACTSEYEKTNPLVPWISLIFGFFSCIISLFWLIHICVYVLPAKPIALFLNTYFAWFDGWFPLFGVLSVAIFTLYMLFAAIKGCFKFGMRCACIQLYPMIVGKTYMSAFLFNVGLVLLCSLPVVQFCATSFSSYARNSTIFRIFGVQIENLGFFGVFWKNNIFTYIFLVWSLLCMIYLWCKPKDGPPSSDALRDRLKSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ26</accession>
    <name>A0AAD2CQ26_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS6991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF6">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1940336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="551" mass="60319" checksum="670CAB3EF0EDE55F" modified="2024-05-29" version="1">MTSVAAEVSLHCMICYEEFNTRDRAPVVLPCGHTYICEVCAKRLKKCMECREPLFWAPPAQEQKTMPSGMNLNSGRSPQPLRYTGGSVNRGRFSPGPQTPPHPAYGGIAAAAPAPTPKKEVPLPLPRNIVLLEMIEAAEMQARMIEKERLKRAHSTRDGEDDDDKLIEPTLAGMTALAGACGTYAVREPLGLAVLPFDPNLQHDKRKAVNAGEEKKVEESREPFTIEDGQTVQVVAAEDGVYKLAREVGYIMASVNQLVKVGGPLEKSCRLEGMLDSVMEKRMQLQKELDEVDLLVNGLRNQIKDEQDQPEEHPVISARKESISALRDELDVGGGGPQTPTTPPKRSQTQDLLLHSSTTDSTDVGLDYHRTPEHRPIYENSPARSCPMPSTEHADVTDPRLQQPFMDDQTGGLPRYRVSNDDADLGITGGLLGFGCGSGLFGERLLEDGPQRNRIQGIDSMLPSFDDDDQTLGGRSFMTARTTGTTGTSRGYRPTRTGSFDGGTVNFRTGMSGHAGLLQSKKHASPNAHNRREVRMMSDHRGVVQARGNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ32</accession>
    <name>A0AAD2CQ32_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS6299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ32"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31403">
        <property type="entry name" value="PHOSPHOLIPASE A1-IBETA2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31403:SF7">
        <property type="entry name" value="PHOSPHOLIPASE A1-IGAMMA3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="8">
        <location>
            <begin position="179"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1938850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="506" mass="57092" checksum="C88293DA15ABE7AD" modified="2024-05-29" version="1">MAPKPKSIYQEALEMVAGALVIYIFADIRELAREGKLDGMTIDDLQAPLTAEQTLAIILANKDKLEEMAINNQDVEDLLKAMKHMQIHHADDQDAIEEGASSGYLSNIWNTGIDTLLTSKTGSKMGLDKVLGSFMNGKKDPPKKKSAKSAVMTNFVDDNSKEEIVHAIVVNQDRKRVSVVFRGSATPKDFIQDAKMSQKKIPNPVKSMMEKERTESMPETINVHTGFYQYLFQMNKETKKTRIETIMEDVKTQLKENPGFQLYVTGHSLGGALSTMYGFFAAADDEMIELSPNGVIVYSVASPFVGNWKWRFAFQELERRKRLQHLRIQNAEDMVTLMPFAVPKAGFFMPILAVKTGAGNLYKHVGMRLKLAQKAKEESELPYSISYPVDQRMDDEEFTKDVQDTLDQGKSLMKAFKAVVTKDFERVERYHSCTEYEERLEKCRDELTGITLDELYADTKIVGSMMEKDYMPKNGGVMSTAFRAMGLGKKKSDTLSSSEMVEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQS5</accession>
    <name>A0AAD2CQS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="191" mass="20864" checksum="FD243D07CF55588E" modified="2024-05-29" version="1">MKADPDACSKVDFVGMTPFHVLGLSQMPCLRLFQEPLSIVSSVDIIMRSQDIFGCTPLDYLFKNRSSHAVNVTKSLLPVVLKPRVSILGLPQWREELRSSLGMVDASDAVSIASEVASVCRKLAVHKWMEAQSLLEIALWGSKVTEQFMGLHKAGDCAAIVLESDQTLVTARENTCINCGINLVLSTRGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS60</accession>
    <name>A0AAD2CS60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS6514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1939273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="223" mass="25644" checksum="5567306CF7D4E7B6" modified="2024-05-29" version="1">MSQSTFPYRLHQVLATESKTGQPDSSSVISWTPSGNSFRIHDQNAFETEILPKYFPKQSKYGSFRRQLQYYGFTTLGLNHFGHPLFIRDQEEQLIHIKHKKGQATQAKKSTTKQKQKKERQIDATPSCSKIANHLRGAQSRSSQHLRNMKHSQQEQASKQLMLTRRQLDLDLLLALQQRRGYIPCAKQQTLLSQPRSTDYSTAQMRVDPASAFIQLARMQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSB6</accession>
    <name>A0AAD2CSB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03571">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="655" mass="69175" checksum="0DDDD3C5B9D7F433" modified="2024-05-29" version="1">MNFIKDLSIDKVRNLAEDAINQAKPKTDVEARVYEVLSHKNWGASSSLMHEVARDTFDAERFYMISRLMWEGMENQRPAAWKVVFKALTLLEFLIKNGAERCVDDARNHGHVLRALGKFNYYEGTIDRGLGVREKTKQITELLSNDDNIREERQRARKLREKFRGNVASSANAGGGGRGAGYENYGNSGGGGGYGNGGIDSGSATGRYGNTATPTFAAMPAEKKKKKKKKKPVAEPAAPAAAAPEIDLFSFDTPAAAPAAAPAGNDEFANFQSAVAPAPAAADDFDAFGTLRSANQSTPGSDPFSAPAPAPPQQQAAAFDAFGNSSSNNNNTANNMGAMMGNNNANNMGAMMGNNTANNMGAMMSNNMNAMSGMNTTTNNNMNAMNNAFGAMNVGQPQTGGMMQPSMQAAPQVAAPAVVGGGGDDDEFGDFGSAPTAAPAAAATSTSSDPLSKLISLDGLTKNPSKKTQQNNTGFNNFGNGGGMGQNSNNNMQMNNPMPSGPVVVSAGGSDAISSMFGPAPVQQPNPHMQQQKQQQQAGNQMNMMGQGMQGGMTPQMMQQMAAMQGGMTPQMMQQMQQQMAAMQQGGMNPQMMNQMGNMGMMNNNNGNNSMQGGMNPQMMMNQMGGMQGMQGGMNPQMMNQMGGMQGGMNNQQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSC5</accession>
    <name>A0AAD2CSC5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000802">
        <property type="protein sequence ID" value="CAJ1939534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSC5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="53408" checksum="B2DD5D197F51AD71" modified="2024-05-29" version="1">MPPKSNIDDEEEESVEHFEFVYDSEDQEITEEIRQSVTKLIVRGPNVKTIKEGGFKECENLKEVDFTEATALETIGEWAFFKCPICENLKKVDFTEATALETIGELAFWKCPSLLAFKCPSNVTSIGESAFQDCSKLKEVNFTQATSLQTIGLHAFLNCGRLLTFKCPSNVKTIGVDAFAICENLKEVDFTEANALETIQEQAFRKCPSLLAFKYPCNVTAIGYAAFSECEKLEEVDFTKATALERIGYRAFYKCPSLLAFNCPSNVKTVGQYAFQQCENLKKVDFTKATALETIEYGAFTDTGPEMVYVAPNVTVVGKNILQNCPKLQSLKIPSVNPAIHIRLYTALYEDQRKNVFTLDDIVSVYACNPIKNSELLENVGDEKSILDQLRAKYIGSIVDGSRRLLSIPDRNWWLQFLVNNVGDGTDDPDMRTLLDHLKTVDIKRVRQLAETKDQSGRVAKSVASKHIQKVFEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVW6</accession>
    <name>A0AAD2CVW6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001669">
        <property type="protein sequence ID" value="CAJ1946447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVW6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="580" mass="62937" checksum="DBBFA982A2391426" modified="2024-05-29" version="1">MASQEHLQQLMNDETDDSSSNSSASNIAGGDTESAIAEPVTTTAITPKFKLPAPNHPPAKKRVKISLKPSTTPVKNDDLEDEVEFPDAKPSLSMAASFPKVPARRRSQSPTQRQRLNKRSLPTKQKASPPKKEVSEREIEATIVDSDDGGDDDAVATAIADEPTPTLVASSERNQQKKKSNLPNYRSFRLPPFSSPGLLVPISHAVTMIKGKPAGDDPSNSASSGGLTTMGSVFDQYLTKLGYTEETRTKIPHIGSSVKRHVGDMFDSNVKFTTRFPKLIPEDLIPSASNDMDDNEESRFSLAERLISVLEVEPSEPETISNETIQESKAAAKDNHSEAPRKRQKLKSWKDMAPLSLTLPYPESFVRKQLEYVDEVNKRESAILAYKKEVETLERENPELLEENSNANQETKKKPATVVPPIPRPPSPPHLSDLATVETREFNDTAHPIYLPKSKELLAHLDKDCFHISEGRYFGLSSNVIADPHFVGPVAPGLNGLNLTASNGLATAPAGGLNMGSLPSQSSLPNTSVNKSGSGKKSASHSQAVSIPSTTSKKKKKKPAIALPLRPMSLIKNAAATTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXF2</accession>
    <name>A0AAD2CXF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS9225</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044581">
        <property type="entry name" value="TPC1_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46988">
        <property type="entry name" value="TWO PORE CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46988:SF2">
        <property type="entry name" value="TWO PORE CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="692"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="351"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="393"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1945081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="738" mass="84306" checksum="7C91B39796B4B69F" modified="2024-05-29" version="1">MQDDTVNEDTPLVAEDGTFTYNRSVSTYLDEAIGSERQHEIEKVWPAAHLIRDAILGEIDEPYDGWYDPHSNPANKMKNKCSLICIRAESRINGLIAVTMWTLILISFFEPPHWCRVLGLDTDHRYGSCGAVLEATDPSDESISYYPNFGLMMLTEHQAHTLQLICVLILVSRILIRIGRNGFEMWRFFHPEIRYANSLRLLSLILLCFKGTVMFHPFLRLLLLGSYLKDCQKEIVSLVKLIPDVVSIMVIVGAITAFYSVVGVLLFDVSEQGQRDFPNWIEGVWTLWICVTTANYPDVMMPSYNKSRFSGIYFVSFMVIVFFLLMNMVLGSVVEHYDLVMENRKKKMDQMLHQDLARAFELMDPNGTGVVTQDTILALFVILNADFLDIRRLSDEETVKLFNSLDVDHSNEINAEEFQEFGKAFAALAAEPDYTTMVQKRFPEIYASDEWQKVSAFVRSRKFEMIIECLLVLNAVVVVIQSYPELAGEYIANDTAGYNGEFNIWEYFESVFTVAYTVEATIKILVDGWTKYSESPRNVFDFTITVSVLAASIYVYYPNDYDDNRLITFVVLLRVLRLGRLLMAFPAFQDITAVALEIIPKSKSVLQLLFFVTYFFSALAVILYGGLITRDPENRLSELLLDTDFASNEYWGNNFNDMMSAMNVMFNLIVVNNWTTCEGGYEAVTEGKMVRLFFFSFHIVGVVLTNNIVMAFVINSFLSHLRAKKTGPESNQDESLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXH3</accession>
    <name>A0AAD2CXH3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXH3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121977" checksum="7EF1EAD8490C93F2" modified="2024-05-29" version="1">MNIIADDEKGPKWVTNELYGRKEELKLLNSIAEEKISSVVLLEGGEGTGKTALIHLVDWHQNDWVFVSRKFEKSLSAEPYSALKGALDHLVTIWAENNQAAQVCQMKSFLKVLGEDVDLLINVIPGVFRIVEKFAHGVCFSKGRSIRDLTRSGDHDAEEKVGVDSGAIAAAFLRLFSFLSSAKPIVLFLADVHYADASSMEILQVIAETAATNPIKYSSHLLLVMSYRKGALEKNTLASKTITSVQKIGDNVNCLHLQDLDVDTLNQMVASLVNADPEDTLPVSIVMHKKTAGNPFAVSQFLRIGREKDYFKFSSMTYKWEWGDPEILDKYASITDNVAELLATSMDKLCIATKVTLKVSSCLGKIIPTHVLVEYFKESYDDGKGHTTCEAIIGVQEHGLEPLLDRACKAGILVKSVSQGAYVWSNDRLQEAAYDMIPAQIRNQLHKKLGMLLWRLGLQEDEEWMIFMAANQMNKYAELRCDASLGNEVAKLNLQASKLSLKKGAIYPALDLLVKAERHMVTTGRWTDSYDLTLDILTTLAETQFKVGEVDAAFEAARSVVDNGKTLNDKFRAHVVLLEGRMSKTDKSYDVGVEKTLELLQLYGEKHPKKFFPGQKCFEKAKLKKMLPGGELEGLLELPDMTDQTALQIQKLLVKYLAPYSNFSTKYVTLGWFASIRALKNACKFGISPDSPMSILNLANYMRREGHYKEASEYADFALLLLERIPRKLGSNHGYVRMVASVSVFSAVRSFNKCLTELLEGRAECLRSGLARESIGTVIAYGTVYLCLGLPIGAFESDLVAYSQEAKSFGVAYTVQQVMMIQHQTILNLKHYSNRPTVLSGLAMDQETELSRVEGHARKMTLRDINTHRLLLSVVFGDWPTVEAMMVALEEYVDVNDAFLLRTHFRRCYLGLAGFALSRKAKTAKARKKYLSIGKKMLKYFTTDMKYGSVNAYPIVSMLEAEESPSKEKYDKAIKACARLGLVHHEAYMCERSAEFFDEQNDDGWSEFYAGQAILLYGEWGATGKADRLTEDYSHVLTKSSLRESVNSSLQGRSRYSAKELDSLRTIDWESFSVGSDFGNHDSSLLGSERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXX0</accession>
    <name>A0AAD2CXX0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001391">
        <property type="protein sequence ID" value="CAJ1945382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2239" mass="254315" checksum="A707265312464729" modified="2024-05-29" version="1">MFLQVCTVSDIVTADGRCIRQSAWCGERDGIHRSPYQWPRTVRPNRNHWRLWQDTLTRALLQSDDPSHQLRQPLGPWFDPIDDWNWLVSPTHGVFHRHGHAWRHYGHRSGSYSSSRRFHMRPASHRTAGIKRPIAALDVAEAPSPSVPFWTKPLPDDVCRVTTQPLHGVEEFVISGVGLEHQSPRPVLHPSLFTAWEAASAEVDEYFGWTPDELEIVGARLPDCPRIKAPIGAQFDLVSSLREALARSKASWEPSHVYGHLDHATPFSSLSWWSKRNVEVDNWAVAYRHQLEASNQLIAPNARFFTELAALYIGGVKQSRLDPDYIQELFALPALRKRWREKLTVTPGPRTVRPNRNHWRLWQDTLTRALLQSDDPSHQLRQPLGPWFDPIDDWNWLVSPTHGVFHRHGHAWRHYGHRSGSYSSSWRFHMRPASHRTAGIKRPIAALDVAEAPSPSVPFWTKPLPDDVCRVTTQPLHGVEEFVISGVGLEHQSPRPVLHPSLFTAWEAASAEVDEYFGWTPNELEIVGDEGRLVEALLSGHLCVISDGSYKRALGTASVQLLPRKGEKDRIIVRCQTPGLPQDQSVYRSELIGLLAGIMVVDWLLQQWAPMLHSKPRVRIACDGFSALLNTFSDNRVSPHQAQFDLVSSLHKALARSKASWEPSHVYGHLDHATPFSSLSWWSKRNVEVDNWAVAYRHQLEASNQLIAPNARFFTELAALYIGGVKQSRLDPDYIQELFALPALRKRWREKLTVTPGPRTVRPNRNHWRLWQDTLTRALLQSDDPSHQLRQPLGPWFDPIDDWNWLVSPTHGVFHRHGHAWRHYGHRSGSYSSSWRFHMRPASHRTAGIKRPIAALDVAEAPSPSVPFWTKPLPDDVCRVTTQPLHGVEEFVISGVGLEHQSPRPVLHPSLFTAWEAASAEVDEYFGWTPNELEIVGDEGRLVEALLSGHLCVISDGSYKRALGTASVQLLPRKGEKDRIIVRCQTPGLPQDQSVYRSELIGLLAGIMVVDWLLQQWAPMLHSKPRVRIACDGFSALLNTFSDNRVSPHQAQFDLVSSLHKALARSKASWEPSHVYGHLDHATPFSSLSWWSKRNVEVDNWAVAYRHQLEASNQLIAPNARFFTELAALYIGGVKQSRLDPDYIQELFALPALRKRWREKLTVTPGPRTVRPNRNHWRLWQDTLTRALLQSDDPSHQLRQPLGPWFDPIDDWNWLVSPTHGVFHRHGHAWRHYGHRSGSYSSSWRFHMRPASHRTAGIKRPIAALDVAEAPSPSVPFWTKPLPDDVCRVTTQPLHGVEEFVISGVGLEHQSPRPVLHPSLFTAWEAASAEVDEYFGWTPNELEIVGDEGRLVEALLSGHLCVISDGSYKRALGTASVQLLPRKGEKDRIIVRCQTPGLPQDQSVYRSELIGLLAGIMVVDWLLQQWAPMLHSKPRVRIACDGFSALLNTFSDNRVSPHQAQFDLVSSLHKALARSKASWEPSHVYGHLDHATPFSSLSWWSKRNVEVDNWAVAYRHQLEASNQLIAPNARFFTELAALYIGGVKQSRLDPDYIQELFALPALRKRWREKLTVTPGPRTVRPNRNHWRLWQDTLTRALLQSDDPSHQLRQPLGPWFDPIDDWNWLVSPTHGVFHRHGHAWRHYGHRSGSYSSSWRFHMRPASHRTAGIKRPIAALDVAEAPSPSVPFWTKPLPDDVCRVTTQPLHGVEEFVISGVGLEHQSPRPVLHPSLFTAWEAASAEVDEYFGWTPNELEIVGDEGRLVEALLSGHLCVISDGSYKRALGTASVQLLPRKGEKDRIIVRCQTPGLPQDQSVYRSELIGLLAGIMVVDWLLQQWAPMLHSKPRVRIACDGFSALLNTFSDNRVSPHQAQFDLVSSLHKALARSKASWEPSHVYGHLDHATPFSSLSWWSKRNVEVDNWAVAYRHQLIAPNARFFTELAALYIGDVKQSRLDPDYIQELVALPALRKRWREKLTVTPEAESETDWTSLARAMRSLPAGVQRWTTKHVVGMCGVGKFKVRWGYDTSAACPCCGEFEDHLHVPRCMAPSTSAEWDRRTVALDSWLDTQVTDPAIKHALLSLLKGVRDPSLPSIRVVPGRLRSAFRSQQCIGYQGLLEGRLSHQWAPLQEEYLQSRGSQRSPTLWASRLSHQLILLGFQLWEHRNSVQHSEDNVQLQERSQQVNNGIHNQFDMGPTDLPKVVQRMLSVKRLTVLNNPLVDREEWLKLLPIFLFVCLPFLPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FD09</accession>
    <name>A0AAD2FD09_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS1371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000025">
        <property type="protein sequence ID" value="CAJ1927915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FD09"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1927915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28435" checksum="A5F1444D76906C11" modified="2024-05-29" version="1">MRSLATSNVETVIVFRALCPVIVAFLDALFLGREWPSQRSWAGLTTLVLGAYMYANEDEKFQTQGYSAYGWPTLYTVVIALEMAYGKSIVKSVPLKTRSGPVIYTNVLGFVPMLLFANLGNEYGKLWDFWWASSEQRFPPASVALLIVGSIVGTLIGYSGWWCRSVVSATSFTLIGVVNKCLTILMNVMIWDQHATPGGIFSLFICISGGLIYQQSPMRGASSKTAETEGSEKVSADEETMELMEKDQGQSSTQKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDC0</accession>
    <name>A0AAD2FDC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000080">
        <property type="protein sequence ID" value="CAJ1929459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="197"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="273"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1929459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="357" mass="40095" checksum="B874528DE618A116" modified="2024-05-29" version="1">MGLNSPFASYHSPEPPQSYTTSMRPHHAVPESDKNAGPLCVLSNLFGDLPADAFEPVPIGESKKRKPSPLIDASVVLELAFMPYSPEPQPTGNLPCYPTQTDNAASSASNNQFGDRPADPFEPLPIGGRATKTSGPSVLDVSVLDCALELALVAVSKSVSNVRKASAPITASAPMVKRRRILSSKNDDQQPHFRGYQEKQWAEQFEELLNFKNEHGHCLVPHTYPKNQALARWVKRQRYQYKLKAAGKVPFTMTDDRIKKLEAVGFVWNTHAAIWDKRLKQLVEYRNKYGDCNVPSNCQENPKLATWIKCQRRQYKLFWSCNKESSMTLERMNALNDLGFSWKVGSDHSVFNRNPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE84</accession>
    <name>A0AAD2FE84_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000197">
        <property type="protein sequence ID" value="CAJ1932006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="11220" checksum="4EC2429B8EA4567D" modified="2024-05-29" version="1">MWEQRNSFQHSDDNVQLHERHSTVNEGIHSQFDMGPDDLPKEIQAMLTSRGRVLCKSLVDKEEWLKLLRQERRDFRRSMKAQRRSLRTIFSPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEC5</accession>
    <name>A0AAD2FEC5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000424">
        <property type="protein sequence ID" value="CAJ1934955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEC5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="272" mass="29515" checksum="D4523CD187656826" modified="2024-05-29" version="1">MIALLTTPSTSATSPTTTCSVLEFSATGKNTSPKTVMDFNSSDSPKKTAMVVIPKYLLPNLRNTSLTSALIQGTSLNGDATFSCTDDDSSVALSAISTDEEESTTATTFSKSSFSSSRRRRAIFSPYWKKSGEEPVEMIPTGDTDVTAIRSPAASVQSCLPHYEQIRELQVKPLRPRVVKSDPILARPMPPSILRKSKYTRRHTVGAVKLNKSADLVATSTAIAGALAAIDIEMEASNNRVQFDSNVDVRVFTKERPMLEPAQPGWSKMFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF93</accession>
    <name>A0AAD2FF93_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000347">
        <property type="protein sequence ID" value="CAJ1934605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="379" mass="42049" checksum="3C19AB3833288AC7" modified="2024-05-29" version="1">MGVKDGAAYCRSSQGFTHTVKLICTRLNDKFPVGGPHNPGVGVNLSCWLVAALKHNVFLMQKWGRFGEALVGILVKAVANNLKLDKQPALLPTLLLCGGGGYVAFETLTSRVDTVAWQTGEEGLDLIRDYFPKITEDFFTSVYGIRDSSRERCSRHLQGGSFDLEHLNLCSNMEPDTESMVVKSACAPCTGILSNRCAVKLAEDIHTLLGAPESRCDCAAGAFCCAHRRAQFLLMYIIQKCDDWDFATLVRKMPEPIHRIVSCAIAVSYCHPSNDKEEAARERKIRQKCLDKLFSQLKKADGNDEDEDEEEENERFEWEDGVPLANPGCKFVVSIVSGGATVEVIKVTALFLAEMEEREKITGRTQKHSNAMMLEEFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGQ0</accession>
    <name>A0AAD2FGQ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CYCCA115_LOCUS6459</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007599">
        <property type="term" value="P:hemostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000011">
        <property type="entry name" value="Coagulation factor X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041990463" description="Peptidase S1 domain-containing protein" evidence="17">
        <location>
            <begin position="18"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="79"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="344"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="349"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAJ1939163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="519" mass="55635" checksum="E35C462E540B2E24" modified="2024-05-29" version="1">MYKLGLLILAFLSRSNASQLRGTTNEANDERRNLYDRQSGLDKIRDSLTSDGADDPMILSDEVVDTDATFTARRPQSRIVGGQAVDASDTQPSFAMHLVDQGGYRFAGCSGSLVSNCHVLTAAHCVAGSRAGYPDALYINAFKPYEGNGGQPFHFSKVRSVQVHNRYNDRTNQNDIAMITLDSCVDNHNNAQYFLNNIIKLADDDMMKTISAGTMLEVSGFGKQAETGNKAVYSNVLNKVQVPFIPQSECYSKYYSGIKDGMICAGYAGGRQDSCQGDSGGPLFIKKGNDEYQVGVVSWGYGCARANSPGVYSSVAYFRGWIENIVCNYGPSSTSDLCGASVAFATTQPPTPPPTSRPVTPPPTPQPTRPPTPGPTRPPTPEPTPEPTRPPTPGPTREPTPEPTRAPTPGPTREPTPAPTPAPTPAPTPEPTPEPTPEATTAPPTLSPITSRPTTTPSTAPSDAIANLFGGQCSQVQGTCLYASDCCGTLQCRRRDNTCVVVNNNRRPLTDRTRMYQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHK1</accession>
    <name>A0AAD2FHK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS6413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004948">
        <property type="entry name" value="Nuc-triphosphatase_THEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146">
        <property type="entry name" value="CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146:SF1">
        <property type="entry name" value="CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1939075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="466" mass="51322" checksum="5D44BF93AD430476" modified="2024-05-29" version="1">MATFKFPHIFLTGHPSVGKTTIIKGVQSSIQQKCNGTDGNVTISGFYTEECRNKSGNRIGFDIVYWPTPATRTQKQPSEPQRVALSRMVDRIQKGKPFVGKYLVDIDNVAKYAVGSISAVETVTTSKNQRSPSLVILDEIGKMEMLCPQFIPAVNKLLDDSSNPTTRRVVFGTLPTPRYGRVIPDVESVRARDNVLVLHVTKDNRDELQKLLSEILSKVLLFDISNDDSSGLIKALEPYRYIRPIGASSLSGDKKKEGTNVHKKNQKADKRGTNLSTGESTATSVKPSGPLLSPSIPPKVLIVGETASPLPSNPEYAYCERSMWIVLSKMFDLPTYKPILDPSSASETAMASYKVVKNLALAKGICIWDVLANVHQKSKGRKKQKPVDTPNDIQGLLKKYPSIEMIGFIGQKAHAKYKSLLHDDPAHDDGRDVQLVTLPSSSPSNTRLSVVQKVDAWKSAFEKEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHQ2</accession>
    <name>A0AAD2FHQ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000791">
        <property type="protein sequence ID" value="CAJ1939416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHQ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="218" mass="25015" checksum="90387EBEA8355A6A" modified="2024-05-29" version="1">MKKLEAREADVEHLTGMLSQDPKPTDKDQPEKPPKRTREIVGQHAATIAQTKDGTQRRSVSKLFKMNQRCNVQGEYGNKTLNEAWPKFLSVTFFKDKVVEWPGHFGNVSSCREDPLVTCLGLHNRDQLCNFVEYLCKRLEDIQFVSDKHDLDNMVFGNRGRAVSQKKLLNMVNYVQKCRENQDTCGGLKTIDRRNSPLLLEEAKRPLRGEVDDPLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK47</accession>
    <name>A0AAD2FK47_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001546">
        <property type="protein sequence ID" value="CAJ1945838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK47"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="232" mass="26803" checksum="8D888AA9D9F00FF5" modified="2024-05-29" version="1">MAQNKILYSAKLDKNMRRSAYFETNKRSVKSNIMLKFVTQAMDIKLQCEADFTTTLEDPIKFLKRIEQFMKKSADAEYDSAVKIKAHAAIARTYTAAQDKFKDDIFEAVLTTGFLCNCNQTRTAPLMLDLQTNYCREVAYDPNTVSKAQDTFKIHMDVIKTCTKEKTNVIKVKVKEKERGNQRIYGKKAASYVCGNKDHIKDHMSPKCPDRLLPKIQWKNQDQYVDYGKKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKM5</accession>
    <name>A0AAD2FKM5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="106" mass="12209" checksum="614B16304A33A3D1" modified="2024-05-29" version="1">MNRSSCTPATEALNRLLKHQDSESLFREESQRVRKKARSLGKRSSSQHMFDLTSILEASEQIKGLHSFPIIEWPTMENNKDIADVRASQMPLIDSLIKSTIVRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNM2</accession>
    <name>A0AAD2FNM2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNM2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08023">
        <property type="entry name" value="GH16_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041968071" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="356"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1947411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="713" mass="77273" checksum="5223CC7966AA78FB" modified="2024-05-29" version="1">MALCLRLLLILQLAALIAAACNQTSNVVNGITTIVVQDNRTVDVLDRQLFYNEEGGQCSANLCGYYIDSDGNMEDMVSNCVYDSRGGGYRSRCTRKSFVNRIRRWESLESCGCCSASLTTRTSPYCEYPSNPPCGGDAACRIPRSRFANSQVCYRDGVSGELTSRCVNAFEDFLVGPTDSYTCGPCPSERIEAPVIDSPPSDSLTCGCSTCTNSVLETLASDGVSSISCRKRIEFMMNNFNMPERDACVFIGDRFPDTCGQGCNPLFCTSTGPPPPPPRPAPPTPPPSPITDCGCPNSCTNDVLASLATDGVASIECRTRMVFAINRFGLTPLNACAMVASRYADACGACDPRTCNNDAGPPAPAPVPVVSPAGPIQEGELVFAEEFNSGDQPNPEIWSYDLGNWGWGNAELQRYTNTRENVQVANGKLVITAIRRGSEITSGRIKTLNKFTFKYGRVEASIKVPDLRNGLWPAFWTLGNNFPVIGWPKCGEIDIMEMGNAAPGNPILNQRVGSAAHWFHDPEGRATYGLYLDAGEDLTRGFHTYSMEWTPNMITTFVDGKEIWAMDISPQQCPSEKCSEFHDFHFFLLNLAVGGTYTGGLLNVNQITAPFPARYEIDYVRLYANQWTEVGGASAGGDTGITPKFDLTNCGCPATCTGQVLDRIATDSNGSFSCRDRIQWVIANVALTEQQACERVGGEFPSVCGQGCNPAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNN2</accession>
    <name>A0AAD2FNN2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001732">
        <property type="protein sequence ID" value="CAJ1947565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNN2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="126" mass="14411" checksum="24564E499E035F3B" modified="2024-05-29" version="1">MMQNLSRLLQQKIESKKKKCMVGTHHKDDSKPFKKYCNDQEENKMDKDKYHKRVAQHAKTAKPTKICLLKPNHKNHTISKCKAINSYKAQMSNKKSNSFAVINLSGDKPDDDSTTSKETDSSNKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR04</accession>
    <name>A0AAD2FR04_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR04"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="859"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1950064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1152" mass="127564" checksum="2F5B7058092B05E2" modified="2024-05-29" version="1">MTITTMKRQRQQCPASASMSVIFQISILSAIVVSSAVDAFGSIGMPQAGRSVPRTLQQPPLHASELKQSSLTQFNDDDDDASSLTSSLQEQNNVLRRHVELGDESSLVGLNDEDMMQAMSEQMSDLLTTLDDGSTTTNYNKAESSEYDDDDEERSTSIPETLNETLLYDVDVYEEEEQEDYEEDPILKELEETLLATIQVLEDTLHETQVVNELETREFKEEQVRLEQELQRLEQFNEQIMAQFQVEQTLAATSSKAPQQLSSLGSLESLLQNPSSVPKEGLVLTQRDLTQLLELQQERHDQEKKELEQQLRHEEKQRLELEQVNLRLEAEASAAAKAMMANVEDKDTTTKQQQQQQQDTEGALLQTKLNEQQEALELANQNLEQVESELTRSKQALEKHTASAKSELAAFKTKEQQLVAKIDKLESEMTKLAVNDAKARETISNLEVAKQELEGTLEKARHETEASKEASTSSQKELTRVKQSLAERMVKIGRMETKLARAQIIAQSSSSSSSLQPKKTTTAPTKKQTEQPPKESSPVVTALKTPRLENWELTKDGEVIGSVFNHPSLPDGEPVRTSALVNPMGARDGITVNTKSGSRYKLGTKKTNKTIAPKQPAAAASTKPAPSVGVKEQVPSSPPTPAATKETKAKKSSPSIDLFANLQNKPAKKETSLKKDEEPKPIKAETPKSKKTVTPTISSIFGSASSKAKKKSKEDTAAKTKPPKTPDAAKSPPSTSIPLPRINFFGNAHTEKTQEGKTKEFNNTNNNNKEPEDQGTGSKRQPYTPFNIFGSKSTGSPKDKLLTHGNSIPAEKQTPEPTKATARTSTSAYGKRKAQKSKAISQQQQQQQQQQQHHKDELTLTGRTICDGKYLLAGKAKKSVTGRCLILGAYHADTNDKPTGNPIVIKLSENTDAMKKEHSIYKRVASGVSKGVVVKCHDFVSDVQDRPGKSALVLERGVRDLKEHRRWIGMEGNDLKEALYSVGQCLDTMHGARMVWTDCKTENFVVVESDSKEEDGGHKVKAIDLESAMNWKEHPRDFTPEASPPEFAKEYVSGDPHSFVLDYSYDVWSFGMLAYELATGIGYYDGNSPDAIMQKLSHKNVPNPSIGIEDDDLADLVSLCLALDPKQRPSAQKIVRHPYFASISKPTLFNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS67</accession>
    <name>A0AAD2FS67_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001790">
        <property type="protein sequence ID" value="CAJ1951608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS67"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="848" mass="94924" checksum="D38CED36763EF832" modified="2024-05-29" version="1">MSEIAVELDDLDGTLVHLQWLEPDESAKTLGILMSPCSNRKAQLAVMQGKAKAWADQIQPSFLHRYNALPLLCTTIQKTLEYPMALTFFSQQEWDQLLSPVLRAALPKSGICRNFPCAMVYAPIALQGVGVPHPYGLQVIKHLDMLLRHPANKTKTGTFLEAVLQAHQLETGTSYGLFQQVYANTSILASDTWAKRTWSELDSLSIHLEFDSPSLQPLRQGDQLLVDLFVDSLVDQLTLKWLNWCRIFLHAVTLSDIVNAEGTAITLQAWKGLRADSCSDRYQWPRTARPSNQWWTAWQQWISTHLTGHSNQRRLSSPLGPWHSVDLSWKWQYSPSTNTLFHREGQLWIPSVPLASTSRQRTFHLPRRFNPDLPPLPVDAVRASVSVFPSRSPIHKSRVLLHSTGPHQPAEPPAPPSSILDLWHHFGSLAESGSHGWVPEVITIEGSEDRLVQALRAGTPCAVSDSSYKAKVGTACAHILTEDRRDIIWITCQTPGKFDDQSSTRSKLIGLMASLLVLDWLSQVAHLKLFASQPLFEMACNGLIALDESFSEVHLSSSGAQFDLASTIRALLRHLPLQVHRRHVKGHWTSTDLSPNWTGGSSAMWKWAPKHNPTAACWSLRAARLSPTPASSTNLCLYSSTVLSLPNWIRLTSWSWSLFLPFKHIGPPRTASPSSPSAWANSWPFGTVRRRAPAPDAPPAPWKIISMPHAVLLLLQRQNGQNAIWPSGPGCRPSRLPQQTAPEIEAFLFKYMKTVRQPSFGVPTVRAWSRHPHLFQSAISSHATLGAQGLIEGLVSPKWRHLQALHFSYIGSKKSANLWASRLIQQLIRIGHYMWKNRNRLAHSEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVC5</accession>
    <name>A0AAD2FVC5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001859">
        <property type="protein sequence ID" value="CAJ1954234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVC5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF470">
        <property type="entry name" value="CYSTEINE-RICH RLK (RECEPTOR-LIKE PROTEIN KINASE) 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="21359" checksum="F7C550A9DAC5E8FE" modified="2024-05-29" version="1">MQLIGILRWLVELGRMDVCAEVLMMSLYNAMPRVGHFHAVLHLFGYLETHPSREIVMDSAYMALTDIPQSEWHEFYPWAKEVLPPDMPEALGRAVKIVMFVDASHASILVTRQSRTGVLIHLNHALIVWYSKKQNAVETSSFGSEFAALKTGVELVEGLVYKLQIMGVPIDGHCDTLVVNPSYVKWNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVF2</accession>
    <name>A0AAD2FVF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRTGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="entry name" value="HprK N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343">
        <property type="entry name" value="DETHIOBIOTIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF8">
        <property type="entry name" value="DRTGG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="HprK N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45206" checksum="A8953501A699814E" modified="2024-05-29" version="1">MYEGDVFQSSQNGNTGAPLYVAATRQHVGKTSTSLALLSGLQKRFDRVGFMKPVGQQSLQVEENGKIVDCDKDAVLVKHHFGLDHLKYGDISPVLIPRGYTRDYLDGKIRLEHQEELVYNAYRAVSADSEIVLCEGTGHCAVGSIVHASNAQVASWLGAKMILVANGGLGNTFDELELNKVLCDKEGVEICGVIINKVQPEKLDQTREYLTKALDLHWDGVPLLGCVPDRPFLGCPALSDLEKLFKTKLLTGENHKLRHYRVQDMNLVATSLQVFLHTLRKNPSRSLYVCHASRNDILLGFLMDHPLRKQGAGNESALVVTGTDEYPLSAQVLDIIEGLNESGNAPPVMLAPYPTNVAMDMIHRYTPKLNFEDDNRVNTTVKHYEPHIDFDLLLERTGHLDRANQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVF9</accession>
    <name>A0AAD2FVF9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001854">
        <property type="protein sequence ID" value="CAJ1954062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="227" mass="23764" checksum="93F4846B4D988178" modified="2024-05-29" version="1">MADQQDKAFANIAQTLQLLQQMLAAQAAAPIAVPAAAAPPAVAVPPTPILDSFDDATPFDISSRQGSAAVAHASAPLRTSWSGVLEELFQFAKHTARVDPRAIQNSRCLYNCLASSITGDLRIEIFGQPGNLPTHGDGPPLLRNLKWHTHPTADCKIRKAWLEEKAAAAAVANAGDVQSKIPIEEGSAASNANSGVTALLANALLMIGDDDALHDVISEALSALHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZD9</accession>
    <name>A0AAD2FZD9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001967">
        <property type="protein sequence ID" value="CAJ1958101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZD9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="853" mass="96638" checksum="10C1C7E93A120DE2" modified="2024-05-29" version="1">MEESNETTKTSVESLSEVVVAGIHGQALHKAPPNTVEKKWPTRLSYLKRVAGTTTSAQLPTLWHELAKCKKHESIGIVQSLLDDEAEKLNLNLEFIVSAQVIKSLVELEFCSRGDVEKGLNVFNSVCFQHYKNANAINDYNKSDYWLTGEKTTMSMKDHQAYDKIKHAIFPRDPMQFREMVNGMRVFYRLVFGKTHPLTVMYEKFAKNVDSIAQKMGVSQQERALERFLFGIYSQIDRYFEHLVRSRTNAEENLPDLGTYMETCYHGGSLPESSLFVVAKDPVGPSGTGDKTESQLKREKERAQKKSLGESVKNPDMNKEHRYTGRTTSELIKRTGEQPPKHANGKELCLIWHTKGECKENCEHDAAPDIDKLPHPAAPMLHRVMKNGAPVVVHSEPWSQSQLDMRVAWGCHSSANEFKEFLMEEFLDFGRKGFFILLPYDAIKDEKGLRLSPVGCVPQDTRRPRMIVDYLFWGLNDETMKLAPEGAMQFGAAPLRIRKALMKANPEYGPVYMYKNDMLDGFYRIRLSTTGALKLGIILPRFEGLPQLVALPLVLPMGWTESPSWFCAFTETVANLTNVDLQQNKRVPPHPLGRAAAITDFEVRDTQVVRPVPQSHQPLTYQRPLKKMEVFVDDFVGMGQDHPSNPLTNQRAVLSHNIDKVFGPNRPTDNQWRKEPQSKSKMAKGDASWHTTKEALGWNWGVTTKTLQLKEKQVSKALSLLGEVLDCKRVSLKQWQQVVRLTPEVREQLEIFQDFLHGHAKRPTTLEELVPGVDLHVGACDAAKSGRGGVWFTDDGEAIVWREPYQEAVKKEVISAVMAIYHTEVSPVLLNQCEASNPREVALIGYYIAPLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G061</accession>
    <name>A0AAD2G061_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1955936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G061"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="108" mass="11642" checksum="0B4377CE5CACF7AE" modified="2024-05-29" version="1">MPTADVTSSCSLPAQQRQQSLRGNPSASRRMDDESLLNFLSSFPPPPPPPPLALSATTIMPFGGGGGRDLVAILDEALELIYDTTSEMNDPCFRRLLDQQQNVLGPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G094</accession>
    <name>A0AAD2G094_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G094"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="179" mass="19838" checksum="43AF547749FC771A" modified="2024-05-29" version="1">MGNSKGVRDIPSVYKTEDSSFKGSSGMGRESCGGSTKEGLAQRSGFATHDPAYHQVCFQLNMNGDILKLSCLCWMLILIEHILHVNGYIFKGLVIAAEFLHISVLRGILMDTDTIRFAEQPINGHQDVSDSILIECYFSEAIELLTYHLTVSSIWTLNILQVDTVLVGTVTDAYSIECW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1H5</accession>
    <name>A0AAD2G1H5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-uridine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS17969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TDD superfamily. DTWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1H5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039262">
        <property type="entry name" value="DTWD2/TAPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392:SF0">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="9">
        <location>
            <begin position="56"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1959548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="364" mass="41021" checksum="0389F73566F8C3E7" modified="2024-05-29" version="1">MTQEEVEYQKEFYQNASQELQERLERLDKDEGLSPATVGKRKHELICAHRLKFGRHPFVCSKCWSYLPVCVCHLATRSSKEWKYKNLLQVLVWTHHREWGLTSNTGSILGLTLGNNDASSHVVDTTHIDPSTDENNPCRLLMKGLPKHDEILQNILDDSARKREGDDESHGVDHDGSTLVVVLWPSSNPENAITLPQLRRELEASDPNNCFDSNPHEEVSDAMVSSSQKKIVLLAVDGTWRNARRMVAKLPSHVKRLDLDESTIRWNDSKATGDENSPSEDSSSMLSILAPLRRRGPSGKENQKTDLKVNASSLDNEKRQVCTAEAVVAALHEVGAIDTELAQQVLYATQTKVDRVRRYRGKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1Y3</accession>
    <name>A0AAD2G1Y3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002015">
        <property type="protein sequence ID" value="CAJ1959744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1Y3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="40678" checksum="031DBF7670950BB3" modified="2024-05-29" version="1">MPNSSYIDALVRSLYDESQEPNVVMLSGSQPKIRSPHAFDSQSEPPRLFTRSANTWGGQFNPDHFQRNAFAMMSASPVNVENAAFPAMTAASHHKYEKNKKRSDCINEKSYLVNGSHVDETIAYNQYTIDTAVLAPTTESPEIKQVILQQSVNSIKQTKTTMEHKVDFLMRRYTSVCPEVRSRVNAATSKLFDVTSDVHEFTSLHVIDNLGQVIATGPGPGLPAPFRAAATYFRIELRLAPRLCSLRTDIGIDPTKFPPSSNRAVYVPVPRVQNQMDVSITRQKVMDQAHHKEIIAAMAALGEEFSMRAATRDGGPDNEAYEKWSKQQIAKTQFQALEQALTATYVGLQQGMETPNQQLAKLNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2V3</accession>
    <name>A0AAD2G2V3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002013">
        <property type="protein sequence ID" value="CAJ1959625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2V3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="314" mass="35587" checksum="43B008C0BEDB47BB" modified="2024-05-29" version="1">MVRIGQRELQALNIDTNNTQLPATSTTQPSGTRVTMSTAGNSTTNRNLPRVLQPEHLETSLVYILETVFCYSAGSILHLALDLYGCKCYLKLIGMDDADIDGLQYPVSQPCDANGDPQPDVLRDVPKPLKAYLHEIRGYVYHQETVLQDPVTLTNCVLIDPDDFAEEFDWGIKLDANLYPTLSDDKQWDSYRHNLEATCCTHGLKQVLDPKYQPTSLNEQDLFDRHQSFLYRVFVRTLLTDQGKKIVRRYNKTYDDQSIYRDLCKFYTQSIKATSTANTKLQWLTTLNSPQTNGLVVICLSFSIGLIPSASTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G370</accession>
    <name>A0AAD2G370_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002087">
        <property type="protein sequence ID" value="CAJ1961174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G370"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="280" mass="30517" checksum="8CF9F1DCA164FCBC" modified="2024-05-29" version="1">MIQNAVFWLNAFPALDGVSDMLLPKYIVTGRNINMKLHVRTKFGAYVQTHEEHSNDMHVRTLGAICLGPTGAAQGSHYFMSVATGKRITRQHWTPLPMPTDAIEAVSNRGLQQGMPTTLTFADRHGMERFNNNDDVDDDHDSLYSSSNASTTHTHTDDDDISYDSDASNVTLPPPQIPVDDDASAYSGNNSVDDADENDSTHSNDSDNDDPDNDQPPDNAGVLPAGVNEHQLQQHQPQFPDENTGVNARNTGVDARNTGVGRGNTGVDARTVLNKPLVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3Y6</accession>
    <name>A0AAD2G3Y6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3Y6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052956">
        <property type="entry name" value="Mesenchyme-surface_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46928">
        <property type="entry name" value="MESENCHYME-SPECIFIC CELL SURFACE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46928:SF1">
        <property type="entry name" value="MESENCHYME-SPECIFIC CELL SURFACE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="3">
        <location>
            <begin position="689"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="979" mass="105253" checksum="63848BEF417BE8D9" modified="2024-05-29" version="1">MKGDITKHDDEENPPTSTDGNDSSKPHPPASDSMEDNVKEREKKLRMALAVDRAPSQEAPSETQETASASASSDPMETAKEREKKLRLAPAFEDPTDHGPEGKIAVGGMKTSGDAGKGVIGAHRFGKSPPSKEKSILELEAQIVEPDEAEEMVTDLQLQVETLQRQVEKQQVAVVVGTEYGDDEEDSGWATCLYNRYVICLAILLVVGAGTAAGVVLASKSNDESSALIAGASDMPTTPTGSTEPISPTSTPSTVPTSAPTIPMPFQYFNRLSTASVCLQFDATCNTDIETSAEIVTATQDGNTIVYTDVPQESIGFMDITNPSTPIMGGLVAVGGAATSVAIKDKYVVVGVSTTNGNFTYPSGNIAVVDIDSKTIIHTMDLGGQPDSLSISPDKNNIAVAIENERNEDLSDGLIPQLPAGFLQIINCAPDDPTQWTMAKVELTGLRDVAYPSDPEPEFVDINADNIAVISLQENNALVIVDLVEAKVVKSFSAGIASVSGVDVDEEDIITQDGSVTVPREPDGVTWIGTEYFATADEGDLNGGSRGFSIFDQEGNIVYENGNGMEEWAIRVGHYADHRSENKGNEPETVHYAEFDEWKFLFVSSERSGLIYVYNVADVTRPRLRQVLPTGVEPEGIYAIPSRNLLVVASPEDNRDDKIRSSVTIYELQEAGPVYPSIIAGNDATGKPIPFSALSGLSFKDGFMYSVEDDNYKKSRIFEIDLSSYPYKITKGIRIKDTAGKLGAAISDLAGSQLLNNDMTVNLDLEGIDAVNDGFWVVSDGVARPFETPSLLLKVNFDGEIQEVATLPQALNGIQGLEGIAVDGDNIVVAFQRPWTGEETIGNRLGIYNVVTSTWKFVYYACEAPSSQNAGWVGLADMEALGNGRFYVLERDNQSGLDASIKRIYEIDLGDYSLADLNVVNKTLVRDLLPDLLSSNGLVMEKIEGLAVDDEGNVWINNDNDGVNGNSGENLLKNIGAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G472</accession>
    <name>A0AAD2G472_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G472"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="129" mass="14834" checksum="69F2D51C31C9D322" modified="2024-05-29" version="1">MGSNQSVNKPTEGTNFPSETPTESETKPRRQKQPPPNLSGPALVEWKCRKRKKAWNSCVGGWYNDRFLPGKALEDERSEQNCDELFEKFRHCYMRGMLTEQKKKGLKVEEGSMLAEFAEEEGMKTESDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4X0</accession>
    <name>A0AAD2G4X0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4X0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042105917" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53541" checksum="CCFD5818D7A147F8" modified="2024-05-29" version="1">MRFVSTILFSTLVIISANANHLPTADFGEGCLNVQDDGSRAQVPDFETHDSFLVSPESRFRFSSDGRHDNQAVRVEPTVKIVSDDNAWSIDAFSTTYQHDEHEAWYKSNNHGKFAASPTWSSESVCQCRCTPYFSDLGTRKDWCSIFDNSHHPHVDFLGGINENQSVNSLDHKPCCFSADKLKSMGPTLNFASLCHVLETEAGSNGDPHFKTWHNEHFASHDTGVTSRVPSFIRIGNAILEIEGSALEFDSVTHYWINYEYQGELTEFAGFPVKMFSQQGTAITKNRIEIDFEFYLSRTDKRLFFLPIRSLSRFLSRMQMKNRLETSVVMLGDFNTGQTLARDGVTVLDDFTELGHEWQVLRIPSGKHLFRVKRLHLKFPETCIDPEHPRGDRRRRRRRRRHLDSSFVSEEEAEAACYGLKDELDRKDCAVYDILATPTRFGHGWSLPTDWLGSRRDICRFPLSRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G515</accession>
    <name>A0AAD2G515_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G515"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="362" mass="41418" checksum="BE4A7901EB6D90BA" modified="2024-05-29" version="1">MATADSTSPCTEYIHIAYPVSPIDRVTWVDLPDALWHEILRFSAVQDLVRMERVCKKFNIQLDRKDRSHGAQEQGREREREREREQEQLSSIHDLWKTHCQHRWNDKPRYKLTDEREDWLRRHYDEHFATVDYGDTAGGATGRATGRATGSRTESSHVMMGNAAPFPVANTASSSPSTTSTPSLSKFSWKKTYFWMEQELARTTLTYDELESLDWYFNFTPLAGGRGKDTLLRCIFRHGLLSIGGAGFPSLPYRMLFLHPGDNPDIFSEQQVNATDQHSDTDTTTDATTDTETHDNPIFHGGIDTSQARRHNQEQAVLIADFPLHYVSRLHDSGEWLMTNAHVTFVSTDEAGALTYKDRNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G567</accession>
    <name>A0AAD2G567_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="15">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS19396</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="15">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="15"/>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G567"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="13 15" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="16">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="17">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1961837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="276" mass="31415" checksum="BE328854DA6FB235" modified="2024-05-29" version="1">MFKPALQNRALSQSFLSQAARSLSTSEASLKTGAAEALSKPEKIKYFKVYRWDPEQNQKPYLSTYPIDLNDCGPMILDALIKIKNEQDPTLTFRRSCREGICGSCAMNINGTNTLACLAYIEDDTAKATKIYPLPHMYVVKDLVPDMGNFYEQYRSIEPWLQPSEEKKEGQAEFLQTKEDRAKLDGMYECILCACCSTACPSYWWNSDKYLGPAVLMQAYRWIEDSRDGSTAKRLEELDDAFKLYRCHTIMNCTKVCPKHLNPGKAIAQIKKKLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6Y7</accession>
    <name>A0AAD2G6Y7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6Y7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="904"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="806"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="965" mass="108370" checksum="9B025D510B66E94E" modified="2024-05-29" version="1">MAEGSTIASDYSSFTGTFTASEPSFSSLQQKERIKYWNQQHLDKLKNEAAGGDTSQQPSDPPESSSNGDFRSGNSGSNDLASVLSQARSGLKSTTTSQASSKPPSSFGVGSSKPPPPPSSLTQPPQPNPQTLSSLPPTQTIEPPQPVDEEAPANVPAETAPAQPIIQTLQTFAETKTEEKEEGEPSQQISEQPIQQHQQPQEKQIYTGPLPHQDDNESTWLNQADDYFRSKYQYHKKEEESKSIGDEESTVTSQFSWLLPGYSFRDQAPKGVQLFYKMPPQPQDPPTGSTSSDSSRAPWNIDPLATLQAQKKSQSKKKKKSKVPPVLQSEPLSAFDSWVPSPYLEKPEPTNREPARIQKRMPLEEERWVLPKEDLEEQRRQREERERLKQEEEMKEEQALFQKQEAEIQRQEQMRQQELQMQQQQQLEQQQQELIQRQQVTEEEFVEEEEFVEEEEFVEEEEVVEEEEVAEEEDDDEEEDAIEEEVIEEEFVDEDTMDEDVSTFPDESISDVEYSSRRFQATFPHQQSQQQPPVTNPQQLPWNQPVPLPMSTQAPVLQAPPSAMKGPNSPRSRNSQSSRYSRKRVSDSSRNSTGNELSRSQHSRMGRLLRKQENVSNSNPVSASHRSRNIPATASKSRTGNIFNSNPKKQERRASTMIPSKASSPSRIGSRSIGSSDLFDDESTRSSSDDDSSAYYDRTKSWDGYPSSESENETDMSSSQRKVRNRRLRRQSQIMEQSTRSDARRRGTKADFLRQQSTAAYSGGRRVPIKSVAQPGYEEDPSSLSFGRKPPQEDQKERRAPGVAFSESDSVSSSSLPSSVSSMPSSEESFISSSSKNSDVFADEYPDIMGGAKDEESNRSESSNSSSSSEEDSSLDTAERRQRLKDKKYDDVLNVGWTPSSSCIGMLVLINCGMMAWGIYGILWLIRRDEETVIAAPTSAPEGITEAAASFGILEGHHNIFNNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7G5</accession>
    <name>A0AAD2G7G5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7G5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="70"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="457" mass="50185" checksum="7E3A17AB47CDA583" modified="2024-05-29" version="1">MTSSSQQTFLTGLLAGATISFAAKWLLDRNQGAAQNESSSKRITKQSSSDTKNKDKIPSIPAELREEQLSRHTLYFGEEGMKSIRNSKVCVVGLGGVGSHTAIMLARGGVEFLRLIDFDQVTLSSLNRHACATLADVGIPKVTCVEKVCHQLGVAGIDARAEMFTKDSGPTMLGDTKWDIVIDCIDDVPTKVALLAYCVKNKIRALSCMGAGGKSDMTRLHISDIRTASRDPLATKIRNNLKRAMKGESDAYLDDMDQLTVIYSSEKVVVKLADLTEEQKEQGDKSQFGNVDGMRIRVLPVLGPLPAIMGQSLASIAMCELGKKPIHQPVTGERVGRNVRNKMFQHITRREQQIEDNTIPGVWASYTGKIQIGPDDIDYLLGMWRNRCGVTGARLGTVLQLARWDLTKPATTDNLVIMSTHALKAYDEEGRGSIPHEVQKRIELRLAEARDVNSEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7M3</accession>
    <name>A0AAD2G7M3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7M3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="195" mass="21681" checksum="5DD13233AD562430" modified="2024-05-29" version="1">MTIGPISDQNNQTIAFLENEEFPEAIQSSSYALRYQRGLLLDEDTSANPNNSNTEPSSQRVDDCMVVCHELDGFGSNSAHSFIYRHGIPIPSTMNDHKIIAAILIFNTALAYHLSAISQRGTATAEKLLVNAKQLYELIIHCRQHISLDDNVMFQFAVINNIAVITRDQGNVAESNRQFDFLMALVNGLRIQNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7V5</accession>
    <name>A0AAD2G7V5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS21526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7V5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1965940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="550" mass="61405" checksum="DAFA2C244469CD74" modified="2024-05-29" version="1">MPSSKAKQYESPLTMAASSTNEEITDEKKKKRRELKSRKRARKEAEEDLEAEKLTAMLFGGNASLGASRLFAVEEEAAINDYHGQHQGDGEDLGFQIDRTGLDGGVVEESPLEQQLRGASALQAFQTKDDNAEEESPAWVDDEDEAELSLVESSNRLRKLRHSREETEAITADELEQRLRKRYEESTQKSARIDWANPSHVEEVEDPIAKFFSTAGTLLKSTRDRLPPNILKIVRCPDANQADYNQSVVRAVNFHPGSDPEKPLLLTAGLDKTLRFFQVGAEKSEKIHGVHFPRLPIYNANFLGSSGNVVVSGRRPFFYIYDAVAGKVDLVPRIQGRDEKSWESHVVSPDGKLIAFVGNDGYIVLVDSHNKHWVGDMKCNGSVRALSFTPDGRYILASGSDGDIYRWDVHSRRCVERFSNNDGTVSASIAATSKFMAVGAESGVVNFYSEQQGMSSSKTPLKSIMNLKTSAEDLKFNHDGQIMAMITKREKHGLKLLHVPTQTVFSNWPTSKTPLKYVWSVDFSPKSKYIAIGNDKGKCLLYQLGHYHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8M5</accession>
    <name>A0AAD2G8M5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein Ipi1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8M5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="889" mass="97924" checksum="DDAAE5874C248174" modified="2024-05-29" version="1">MSSKRKSGGQSQSDFKRLKAKVGKRAPKAANFTDTTFKSASIRMADQHALQQIGTGVASARGRSMVDLSLQLSHHAAAVRLSAVKGLGDITRHESTASLRPHLALLIPCCAKSWVDEDDDTRTAGLTTFGELLRKQSETSIRPFMPLIVAYLTSALHSLDSTMRVDGAKAVHLVCSVHPKLLRPHVAKLLKPFIGLLTDRGKLAAKAEILLGLVSLMKVSKVDASDRQLKRASIESCPHFTFVSGGRSRNAIVVEGRSIRPPVAPLSSIQDILSLDRSRAGRTDGENDDMEVIQELMEKVRNILMEILESETMEVAKTKKSPSPQSKEKLISLVFQAIGLLWKRKTRFYEGQPDNEPPEKLQKLAVQVLSILLDMLPLQRGDFKFVNDSTVESLNSTLCTTVMTIGATVPENICQDSEGKQLKWKSQLSSFLLPHLQRYKSDQDYPTSALNVTCDLLLSSVDSASNSLYDHGSAMLKAINEIFFQDSNAALARSQAGRKVAVTVCDILTSLNYPNLADAPLLMDMTSAMSSFLNFWGADCEFETNVTFDALLGIVRSNGTDSELGNTLRNRMEDLVLTEEKGERPAFEIYTTQSQSKFLALMVMLEKPSASCLKGLAKFCSKSSNDTSTADAIVSSLQAIRRSIPMKNYIQFLLTSIVIPKAKSKRKNQSSDEPFASFLSRMGTMDSGVRRVSVALIECGSKRILQMLLPFLKDLLKPKEELEAADSYLRYRASISLLALILLDIQVTTGETDVPPELNEPLVNALFASIDFISASKNSMGGATKLLSPLIGVCHAEKVLLLSLFDRIVDKVADYKTKQHQLKNIVRLLVDISNDDRITARLDGFDQLRGSVLALKQSVQKNGLQKLEGIDQLQALVDVRTGYKERQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G904</accession>
    <name>A0AAD2G904_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G904"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="226" mass="26193" checksum="3D8CE171693AD946" modified="2024-05-29" version="1">MPPSVDDYGEASVELECSTNNDNRTAKPIIITSANSQGMKRRVSFSDKTDIRHIESTKSISKKERKTRWMMGKDFLRIKEDCDNEMMRIFNSQKPCMRTDLRGLELFDPESICRSRSKHRKVVNAVIRMQDKQSDKGGVNPESIREMYCYLVQDSQDDARAIAWIDREVVEDYMATTMTEFEKVQQRNQRMSQLKAGSSNKSKGTKPALRHRLLKSFRMPKKVPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G959</accession>
    <name>A0AAD2G959_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21906</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21907</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21908</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002275">
        <property type="protein sequence ID" value="CAJ1966322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002275">
        <property type="protein sequence ID" value="CAJ1966323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002275">
        <property type="protein sequence ID" value="CAJ1966324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G959"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="25542" checksum="94C8F68B15DD9AFA" modified="2024-05-29" version="1">MMESPYRPQPHNNDAKDGAVSSLLPEDQPEPTSPKPRVSPRQQRRFSPWAVDLNLQRGGTTAGTAPSSRTQCSTSSWKMSMQQRKAVYGEVAVAEDEEEESDQENGLDQPSLDHDDEGPTPQQKALQYIQEQRKQKELEAIEKQQKQQEQQDPPSSAESKTAEDLSGLGTVLEDLVEEEEEEEEVTSPDAIETGVPATDTSTTEAPTTAAAVVNDENEGLSEMEIQRKFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9J7</accession>
    <name>A0AAD2G9J7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS22456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9J7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050110">
        <property type="entry name" value="Glyoxalase_II_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43705">
        <property type="entry name" value="HYDROXYACYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43705:SF1">
        <property type="entry name" value="HYDROXYACYLGLUTATHIONE HYDROLASE GLOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005457">
        <property type="entry name" value="Glx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="59"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1966871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="302" mass="33189" checksum="83434117DAC396DC" modified="2024-05-29" version="1">MKSRQLASRFSAAFTVLSTTQSPTAWAFQPALSNHSFGSRMSSTRVPKFEIAQFPCRSDNYGFLLHDPATGNTCAIDTPCATSYKKVLDEKGWKLTHILNTHRHYDHVDGNLELKTEGVTIIGPKNERKEIPGIDTKVGGGEELELGSFKAQVLEAGGHTDGHVAFYFPELSVIFAGDCLFSLGCGKMFEGTPTQFWSSLETMRSLPDETMVYCAHEYTESNGKFALSVEPNNQVLIDRMAVVKQKRARGAATVPTVLGEEKKANPFLRGDISEEIQQNVGITATDSPAEAFGKIRKAKDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9S9</accession>
    <name>A0AAD2G9S9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS22458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9S9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052085">
        <property type="entry name" value="WD-SAM-U-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573:SF1">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="96"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1966873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1180" mass="132461" checksum="4D89FBEA43A1CE41" modified="2024-05-29" version="1">MAPKKQRDAARKEKIAAKKKEAKEASAPIERDEKTKPSRDHWLVPMSYKDIPAVESLGIPSAGGLQPAHNIIELLVKERGAMIILENNTSDLYNKKLQEALDEAQTQATSGISRQFRKASIHVHPDRHGDLYWKEFDRLKSAYQIMKDVEVRKDYLDHMLHQVLIHQTDPRARTIHNFFQAMHDQWHEKYKKSQEQDTAHARYQQQQQQQSRNYNDLRNVGQQHYFIDTSERTRQPGHSSICKSSAVNRTIVLGLHIRNSEELLFSLHEVVIEAWPVEDEEDRNEVKRLNREDLKSILHEKEEDEGSHRFFRVPLEFDEHCKWCIQWTVILHIPELPEPYVSTASTRRLAFDLRHPAWKRSIHEYPILLNFAKIDATALSKFCQKLAAQEKMKPEALETESWKLHRLLSKGRSTGRRLHTCLEILEYSIDRCEPLVLLLKACDEGVHAKSILDQHVFAGQKKNALKSFKQSVATMIESGELSDWLDKVQMDQLKNHGGEANRLFQLLVEGKKANSLLVDSTALRKAADRLDLFSEKQCQTLLERAVQTDEQMAIETDRLVKEEHAKKKEETQRARLEARAKGMPLRGSEVELFGLQKRADLNGSVGLYMGIATTTEDRYIVKLFDGSEVSIKKTNFSLYERRNKVGIESMTTATSNTSSTAGPSGSSSTASPTRKNKTTKGAVLPKAPKPARAGKTSSNSVALKEEASTSSPNAISPPHRKHATWIPKDRFSAFIGPRGTNVRRLSLQTKVNYIKVMKEEVYMTSDGRKWLFVKIGGKIQNTLNAVKAINRWVEESESENTAQSIPDEARKGSITTPSNIKDDAPSQASAKKNGTQVKSSKKPKQNDIKGAKSPPRNATPSPTSTMEPMDEMTRYYSTTEGNNDPTTQNIKSSAGVRPIGPPSTTKIPHAVSPVLAPSALEVGQKSTFPGMLEFLTENVGCFKSSSKAFFDYLVSMDIKSMRDLAEATADNDLMADFIENGLKKFKKGSFKKAVVAIEPLKESISPMMMAASIPGLKEFLSQHAGSFKTSPKAFSDYLTSMDIEGMRDLAEAVEDDDVIADFIENGLKKFKKGSFKKAVLAIETLKASMIPNPNHPPVYDAATPDGLTCPISFQLMINDPVLAADGMTYERAVIEQWFERNQGSGCILSPMTGEPLPNLHLQPNIAVKTMAREHERSAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA20</accession>
    <name>A0AAD2GA20_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002321">
        <property type="protein sequence ID" value="CAJ1967282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="432" mass="50457" checksum="52DAADAA91ED8A4F" modified="2024-05-29" version="1">MVDASKEFVAEIGAYVHGYGHDTKNNMAARTIKGVYMGPTDDIQEGHRIYDLNIKCKARHAKIKVLPMTDQVIKIIEEDARLEGVTELCTYSKRNGELILDGDLLEGVDPDELWDENYVPVNKIERLSDVTLQNENIPDDKLDDLLMDAEAEIMEARFNRDRNPRYDSEANQYEDELEDKMFDRMFKKIKAKQDAEDLMDKDYQEHEWITANEDMDYEDKYKSELGDEETKQMLDKLAAELVELGKPEEEVLFEFDDDTQEDVAVESEEENGVARAGVRFADTDDNESNTEGIVRSYSDDGVKVGAKRVLRPRHNRSYFSQGVKMRPTERYRREKSRFGQAYLQRRNPPVPNVLRNRRAMRRKARMKRLQVLLYQAIKKRIDTRRNGAQLQRNHKYERSIQERMHNLAFQQVRNTNKGEYDADKALVVARVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAF3</accession>
    <name>A0AAD2GAF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF18">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="191"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="286" mass="30590" checksum="920586DD43BEA215" modified="2024-05-29" version="1">MSDNTFTYVKIPVNSEEPIEELSASKSGGLEKDALVKNAKAYFQQQSNSDQPSCEIMALSIPLPGNQYRAVSLYSSDLPGASTKENERATKLVTACGHSLPKAICGDVFIGRAYDNEEFEWERVDFRASDASPTAAWCRVARQKGGGGGQGGSASSLNSLVQQQMNVSGGPPHVVAPQTQALYGMDGAPAVVEDWGSWTQSADEVEAKLSIPSGTKSKDCKISFKRNQLSVAVHGETKISGILFSAIVPDDCTFTMEDAKDGTRDLCITLTKANEGSTWSFLTETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAP9</accession>
    <name>A0AAD2GAP9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="325" mass="35023" checksum="29561A0BDF0D4682" modified="2024-05-29" version="1">MGNCVTQEMPQPQQRRRAPNTEEDEYETRSVATTPTRDPEVRGAEDPSSSNGYSPSEKEITEKRKEGLSKPIQDSAGASVCEPPIEEPPLIKHEISEPAKDTKDSAVAESPAPKKEEPDIVIPPEGGESLEAADQAEMKHASSRNLGKMGAEIPSDTDSMSLSSQVSSNEVEPAAAAGSHTVDKKPAKAPTSNSTFKRSAGIFLSSIGLLAGSIMLTQSSGPQDIQSILIPKAESLPRPPMDCKGDDCPFLNWLDTREGLCSPDQKRSVADVKFTPCPPYSSNSTLPLASAPACNFASWVDAQDKIDKCSLDTDKRFDQIWSKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBP9</accession>
    <name>A0AAD2GBP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="9">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor 4 homolog</fullName>
            <shortName evidence="9">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS23525</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="9"/>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="124"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="180"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1969076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="681" mass="74945" checksum="59E583EC3010BCE4" modified="2024-05-29" version="1">MEDIRNFCFIAHVDHGKSSLSSRILEITGNMGRENQIAALQTAKGEDDNNSFNTDNGQSQEASSKISKQREQISLLYDTLLHVIDTLSVEQERGITVKASTASLLYPHPSAVGEEGVLLLNMIDTPGHVDFGREVARSLSFVQGAILLLDATQGIQAQTWTVHERAKSMENPPELILAMTKIDLEAARPIDVALTVSEWLNHDDPDSIIPTSARSRIGIVELLDAVCTRVPPPKPLADDDGSIMRAQVVDSWYDERGVNCIVQILSGKLEEGDRLSIVAADSTDKQRQSYSIQEVGLVLPKSIRTSILQRGQMGYVRFGLKDPRQADPGTILIDSKNEGKEVIIPNRQNMDSTKSVLYASVHPEEEDGFEDLCEAVERLALNDKGLEVSKTADMGSNSSESGGPFLGPGLRVGFQGLLHVEVFRQRLTDEFGIDAVVTPPKVPYHLTFLPTKSNNITEPYTEVIEDLAEWPAYGTKFKVEEPMVGVRIMAPVEYTGAVMEVITKKRGLNLESTPLDEDTWIFEAQMPWAEVVVNFHDMLKNVTAGYGSLDTFEGNPSLMEAKLSKVDIQLNGESVGPLSFVSHTPNAQSEARIVCKKLQEVLPRQQFVVVIQAKADGKIIASERIRAYRKDVLTKSGKMVGGGDISRKKKLLEKQKKGKQRAQKGGKVTLSQAAFNSVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD05</accession>
    <name>A0AAD2GD05_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS22983</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 16">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002349">
        <property type="protein sequence ID" value="CAJ1967885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="133"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="538"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="337"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="443"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1967885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="950" mass="104646" checksum="481FC4CB936DD572" modified="2024-05-29" version="1">MPGAFPSQDRGSAENSPTKSQIEENQPTTSLESTVGESSCEQDAIKNPVEVGFQSIAAFFGMPLDSTAQHSIDQAEESSSLGSTVIEQRSPIKASSPIKVGRSLYGNNRVETNSTTHDSDQEGEYTNFVDAANSPAEDFVDADGHIWRSRFCLLEEGVLYFYRNSQDANSAIAIEERQNVQAQPEQNGIRLYSPKDLSKSPVSKGMHGQSGSASTEEANSFTWEKRVFLNSVGSVRSAEQEFGANAFQLEAISGDQNVEKTDTLVLCARNEDDMKEWIFQFHRSLSWFMRSFMKSEIYMDIAYPITSHQAASFIPFHRSDKDVQRCFAPSPILSEEVEKKGSLSHGHGRIGLQRSRQLTTKSMSLDNEAASDSIASIPRTGLTSKQDQKTNSTSNGDGKSSKARAYIPPHLRRKMQASQNLADTNGLTYHTDESDVTDFPAEKEAKDSKHTGALREKVHGGTASSLKNGPKSTETPEPAIYHKGGCADPQLVPVSIVDSRYIPRKASRLGPNAGTPFGCFGGEGIYETSRSTAPICWETGAVSECGIRDSNEDAYLISNDLLHDQNYEQTSETNRAKTNLGSHEKVGLFAIFDGHQGDQAARFAAEKLGGFILEEIENSYQKQAMTVPSLDSPRLELTARNAMARLDREFCSLCHEGGREWESGATALVAILVDKSLVVANLGDCRGVICRGVVDAESYLTDDAWHDVDFPSSNNGMGDGLRIDTTRFFWRGITNVHSPSVETERERIEEANGWVTTETEIPIGQLRRIDFRDEDVVNILKRGFSEAEENLSSGVGKQSKAAPQRILEIFRVCGDLSVSRSIGDRDFKAEYNPPRTNPHKDDPSSQCWEGPLYLKYPDDHNGRFKGDLVSCVPDFQRIEVGEEGVNNEFLLLASDGLWDVLDADDAIRVTRELLVRKKIDAKQAAARLAELAIHLGSSDNVTVIILIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH29</accession>
    <name>A0AAD2JH29_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="142" mass="15601" checksum="079E516523CB0E05" modified="2024-05-29" version="1">MSFSALQGATLISAHCGLTKLIISFTYRTYNFFGPKFLGIEKEQIDKFNENFHVKEFQKAIANESEFAAFLAGPLFYLALAGVEASQGATLAVLGQVSYVWTRTALGYPCIPTIATAILRYAGMALTFVELWKVAFPAKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHJ6</accession>
    <name>A0AAD2JHJ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS12541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040001763">
        <property type="protein sequence ID" value="CAJ1950343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHJ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="98"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1950343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="636" mass="70962" checksum="4FFB0AF679A8773D" modified="2024-05-29" version="1">MHSLFLIVTHVFGLFLFVYGIVFRMISFSNGDECEMTYSMREFVEIATSFESTSPLASSYNLYKFLDRRDPRYKSLMRAKQPISDYPDWCGKSHAKVKVVLFIPGHWGSYTQSRSLGAHGLKLTGKAAGATVESIVNALERGSLSGTAQNEEEFIFEVLSVDFGEQGAALHGSFLISQTGYVSEAVRHISRVCDVDSVTLVGHSMGGIVARLVPVLHPENAHLVRDIITLASPHSNPIYAFDYSIREVYERLERTSGGEALVVSVSTGLKDEMIEPTSSFMQQHHSSFSVLAQDLLHNGEFGMDHQAITWCFDVLHSLRAVIWELSTAGVEEDVVTRLQLVKNHFGADSFATNYILSRNDLNTKFGYIHASSIESGMVYNIPHLFSFFCILSGLRCSFNSKWDTNNLILTVICGWCFCDINKGSILILTLVANTVHALISSTIPVGFYMAEDLGASIVMILVPSTAVTFLSVSLRGVVVGATTLQYYDSYLFLFVIDCILCCLFLIVGFSRSLHQRRDLSFVASAFLVTIISAVGSFSLILWGDRPQARNWQSLLLILLSVHLYLMQQRRRMDHELALTLNIRDYLILGTIVAGVSKLLLERGHAYRLVFFIPALTVSDIICNRLATKGRRRQKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIE5</accession>
    <name>A0AAD2JIE5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS14199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIE5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052788">
        <property type="entry name" value="RING-type_E3_ligase_ATL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798:SF97">
        <property type="entry name" value="ALCOHOL-SENSITIVE RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1953599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="196" mass="21767" checksum="857AA2B4143B8CF8" modified="2024-05-29" version="1">MDLSESRYLRFHDDSSATMHRFLDQVPPGSLPSETEQQSSLPIIFGMIVLFLFVCVAANMSCRCGHSRSNETSDDPSALASPDPKRREAIEANLFSGKVDATLQAGSNTSSAIVFQPRQPAKDEECSICCNHFFSDEAFCIVKSCNHLFHKACIEQWIFDQRKDFCPVCRREVSGGGDGCKEIEMVSSQENNQPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIL2</accession>
    <name>A0AAD2JIL2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIL2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="178" mass="19042" checksum="D30FD151420CC6FB" modified="2024-05-29" version="1">MLIPQISSALYAGMVLISPDVPSFTQSSYRPQPTAMITAAPPPPTTPSTFLVPSPSSNAARLLVEPKSGSFARMANPQSSSSFQNNFALQQLFQQRALQDARLEQCQETQEEDFEQCFFYGTGGIDRMDGMGLIGGGVGRGRGLVGARYPSNAGIASNQDGTNSMMLPSSKKTTVPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIU4</accession>
    <name>A0AAD2JIU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="15572" checksum="8EEE69B0DDCCD6FC" modified="2024-05-29" version="1">MSKAPMIAGTMQTDPRSGGVKRSSGVTILPVVTEAWAEVRDDGNADIDWILIGYEGNSKTDMTLLEKGSGGLEAIANVLPPGVPSFGGVKLSSGKFVSFLYIDDDCPAMKRGRTLMYKNGVFNALEGCVGEIEMKPGLTEADMGPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJD8</accession>
    <name>A0AAD2JJD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Isochorismate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS15590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07037">
        <property type="entry name" value="TPP_PYR_MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02009">
        <property type="entry name" value="TPP_SHCHC_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01659">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916:SF1">
        <property type="entry name" value="PROTEIN PHYLLO, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041947285" description="Isochorismate synthase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="9">
        <location>
            <begin position="310"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="10">
        <location>
            <begin position="622"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="1332"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal" evidence="13">
        <location>
            <begin position="1885"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="11">
        <location>
            <begin position="2203"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1641"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1647"/>
            <end position="1659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1955113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2360" mass="258712" checksum="D2FDB75EC2E25497" modified="2024-05-29" version="1">MKRHPLHKLAVLAATAASFTNAFTTTSSHYSNSVKLPFLPKTAQHASVETTNEGHLVNGKTNGAPSELELDTDTGRTLSPYNILYPEHFRITSSEIMKRESTLHTCLQLLRQVLTFISSGDATLPEQARVLRIEHAISHNIDPLCWLQAQKEADDKPPSLYFATAEGTLEAAVYGSSKIYRGTTFDDHFWDLVQELPEESHFYGGQRFDTETDHSHVADEWASFSKGLWILPAIEIRRTKESPADTMATTTVAVHLYKDDGDDSIGFSLAASRLLTLLTHVSDATTPAKAPTTLPPVLSRVSTYANRDGQEMYETGVSAALAEFSKDNNTLEKVVLARRMDLSFSQHATVDPLDILRKWKFGNKPGGHMFCIGAGGEGGDFFGCTPERLFQVQHGAVVSEALAGTRPRGSTQDADEELARQLYSSSKDQMENRITGKFIRSAFEELKERGLVTVGKANTLEDSSEDYEFGGTFYVRRLRHLQHLCQRYSCDLTDNTKPTDVIKFLLKQLHPTPAVCGFPQNQAIEFIREYESSNFDRGFYSGPVGFVSKQKTDIVVAIRSGLASKALERPKISVYAGAGIVPGSTVQGEWSETSYKLAVVSSIFPQSPITLQSIPTPNAAWAAAFIEELVRNGITQFYICPGSRSTPLVAAIAKTARTNIGAINAMSIHDERGAGFRALGYGRGFGQPAAVITSSGTAIANLYPSIIEAGMDGVPLLVITADRPYENRNTGANQAIDQVKAFSSTYVRWFRDILPPSDDVPVAVGLSDASHGVNVAREQRGPVHLNIQFRENLAPDAGPIRNDDRIGSITKFDGVRFTDTPGFQRWSFGGGVWTKSFGNTGAVDTNHVAYIAKLIKNSKRGIIVVGNIRKSTTQSHSDVAETFQMIDNLAKIIGFPIFASAQSGGLRFESSAVVPFAEHLLRCPLVGENLRPDVVIQFGSPLISTEVTKVIKTSTADDNLQHVLVHPHHPSERVDPEFTVSQKVDSEILPFVKYLCNVLATGPLSSSSLSPIIGLGRSIQNEIRSIVDTAAADVWMNENGTVTMTEPEIILSLSELISRQERNEYSLFLSNSMPIRDAEAFLYPLSTPSSRTKGWKGVVDIAVNRGASGIDGIISSAAGFADATKRKTILLVGDVGGMENSQTSCEGVNPDTFLLLIQQVAALHDINSLHGLKSGITGKDIYSQYGNHLTTVVVNNGGGGIFSFLPLSKHGTDVGFEEFFATPTTTFSFEKGAAAFDLPYQKVRNFDELFQSYLDSEKKEQSGLIEVEVVARDSNVKVHGKITREISDVVVRKLGGHAADDYSKEILPLAVYNNMHSEKSNRSSTSFERKTMVLLHGWMGDKSEWDGVVQFLIELLPPEWSVISIDLPGHGESRMRRSNQFHSIREALGLREESDSNLDVDQIARSVFVTLRKHNIDFVDAIAGYSLGGRVALAMKRMAMNNYHDGDLPDFSCLNDSSRLVLVSAFPGDISSNATEVPLHLQNEHKTRKHKDDRLSQEIQQMANNFELTPRSPSDAKIHWSKFLQRWYSAPLWGNLKSSGDLYNVMIDKRVSSLSNRAFDLAAVLEQCSPPLNRLDDWRAAQAERTLFITGDLDEKYSRIGDAWQSLSPTLSHKKLKDKGHALLTEAPSEIAEAINSFLQTDPGEENSQKEAGEIDDKISSIPPYPKDSNRMDSAGIAATASKFPHFQMEEVIGSLEFEPFAIDLVDGGKKTKGVAGIGWGDRSKTAESSMKRRHGFIIQLSSEDGTKVGIGEVSPLAGLHPESLGDTEDQLNAIASEIAGDRDYTMPGFDPAQILAMDGALDEFLYSFCVALGIERLLLSVRSGIEMALIALSSQIVSMPIHQALVKFSPSVYKVRSSSSFLPLNGLVTRGTLPLAISDKNAVAYDSWKFKIGHQSPANDLRAISTALQLPPSNAGGQKPLIRADGNRGFNETEALEFLSAIRDIGLDRLEYIEEPLRVASEMSSWSLREHTGRLQKLYEETRVPFALDESIVDLAELHSYDFSSIMEDLKRVVPTRSGCVALILKPSLLGLELSLRLARAAKIELNVGAVFTSAFENGVGLSFIAFLASLSDQTGGRETTRLFSHGLGTFEMLSADCLSPNFASYVNTKGQVNVASLSRAFFGLSLDEMESLSSSSLPLLQAQLSDEDAVTASSLNDVQSSGRMLSDEFEASTTISSDGREITVVASLPLPFSAEIANARFTDLPQQPRWSPWISSVAYLDDGETEWTLQVRGIHFRWRATSTLLEEPYKGIQWESVSGLKNTGFVEFIPEDDACLMKVTIAFISPRILSSLFRGTSVFFEDFLRNKIFKWSLEMFRDVVKGDLALEEGNIDLGDALFSSVEGKANAIQASLSAPFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK62</accession>
    <name>A0AAD2JK62_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001970">
        <property type="protein sequence ID" value="CAJ1958330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="174" mass="20158" checksum="8ED500447E3D4BB8" modified="2024-05-29" version="1">MMSGGFQNAGQNRSQQGQSNGQYNGNKSGNGSQKEKKFHPLTRGNIPEFSFDEVKKTLVIKMSTMKMDHIDDMIQSVRTMNLFDIQSVKPTLVLVTNDSNPDKEIKNEERRTNYLADQKDWKARKNAFDNNKRNVYGMIMKMCTDHMVDKLEREADFDNKLFNDPVELLMRIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK79</accession>
    <name>A0AAD2JK79_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK79"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="354" mass="38264" checksum="883DC520E22C9244" modified="2024-05-29" version="1">MDSDMMRHWGRRDVYDDWRHHSDSDNEDENKHLRLRGPLMSIAEVCEDSSQEISHHSRTHGTEYGGEGKEENKVDDRKEDERGHKQNSVMNNSHSNKVEEEDHEVSDHKDEDFMNVPLHSAYGLQAEDLMLKNSMALPTGDGGKYRTVSVFGGVFGMLPDPVDSDNLSLSSASDGFSSDDDVYSPPKRSPKRKVGQRRNAGAPPLSTIEPPKQTTPPAKAAAVSPRVVSPPSAASPPSITATGSENNSPPATATTSTEAGAEAKPDAATASVPSSTSSPTQPSEKRANDDSSMTRALKAFDQTESLLCKVLGDLESAPFYAVPPQVMEDAITTLQVSKQSLESALCLEDVVLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKA1</accession>
    <name>A0AAD2JKA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKA1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="514"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1957636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="78412" checksum="309369961B762B3A" modified="2024-05-29" version="1">MAALGIDEAKILQILENNIEDVATNNIRESNEEFLNTLHGYLDCRAQMDAEYNRVDTKQELASFEMESDSGGIEDDTLDDKNMYKYEYQQQSTEWEPVKDICELYAAAEMIRPVYMEKVESLVAQVKEIHGEGSKIKIKIPPLKGKERAMAKAEDDYGNRDPGPAVSWLYDIVRGSVLFSSADCLLTCVRLIKEDESIHIVKSKNRFANPTLTGYRDWNLQIKIEEPEEEFEHVCELQLHHESIKELSISSHSHHYYEFFRKYFAGATDTLTDRLEDLKIVAGGDKLDGAFLNQLLEETGDLERLKRLADLFGDFLCEFQWTNKVYAKILKQQLADASQEDSFNIAMTINNLANNFQQQGKLKEAYSMYEQVLQLNKTAFGEDHASIAVTLTNMANAKSRQGKSGEAMALYQESLEMKQRNLGHDDSSVAETLNNVGNALHKQGKWDDAMAKYKEALEIYSGTLGEDSSSVAVTTSNMANVLKSKGELDGAMEKYQEALEIYKRTLGMDHASVAVTLNNMGNIMEEKNSMDEAMHFYEQALSIKKQTMGEEHSSVAATLNNIAAILQKQKKFNEAMAIYKSVVKIYSKTVGEDHPNAAITVSNMANILKLQGKVDEAISRYQQALVIKRKAYGEEHASVAITINNISTLQEAQGRLEEALSSSREALVIFQKTVGDEHAHTALVKKRITRLESKIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKK8</accession>
    <name>A0AAD2JKK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SOUL heme-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF58">
        <property type="entry name" value="SOUL HEME-BINDING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25780" checksum="45783FC691BB0031" modified="2024-05-29" version="1">MGSVFGKQTVAEPFFEVLLDRNQAQTQYELRHYPERRYAATCVYDGDADDTSPPFRALANYIGVFGKPQNESRESISATTPIVYQGSTTKGESIAMTAPVVTEEVEDGKRVMKFMLPAEYDELSKVPKPINPAVKIEEIPPQVGVVHKYKGSLKAEHNKEMAIDLADQLMADGVEGISEEFVLDNFQFWGYNPPMTIPYLRRNEVWLQLTEEQVEYLTQKYNNRSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKS5</accession>
    <name>A0AAD2JKS5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS17662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000151">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042106318" description="Aminotransferase class I/classII large domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="114"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1959241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="506" mass="55267" checksum="51AA97B951B77AE1" modified="2024-05-29" version="1">MPIVSALLLSALVLTTSTLGVDGRLTLDTMSSSLKRMEYAVRGQVVIAADKIQADLTAHAPGSEDFDFEKILYTNIGNPQSVGQKELTWPRQVLSLVDLPNEVGVDHPDVLKMYPKDAVKRAKEIKLGLGSGSGAYSHSKGAKIFRDDVAAFIKKRDDGVASDPEDIYLTNGASAGIENVLKALIADPSCGMMIPIPQYPIYSALLDLHNGQKVPYYLDEDRCWEINIRELERSLTAAQEAGVNVVGLVLINPGNPTGQVLSKEGVQDVVRFCAANDLVLMSDEVYQENVYDDTPFYSAKRAAYDCGLLEDDRLQLVSFHSASKGVFGECGRRGGYMELVGFDQTVKDHLYKLASSGLCSSISGQIMISLMARGPEKGDESYESHELEKSLIFESLKRRSKIVEAGLNAVEGMSCQPAQGAMYCFPSVQVPDRAIEAAAKLGLPPDTFYALSLLERTGVCVVPASGFGQRKGRFGFRTTFLPQEEDLSNAVSAIRRHHEEFSLKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL29</accession>
    <name>A0AAD2JL29_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="135" mass="14936" checksum="C98D8C1F700A2832" modified="2024-05-29" version="1">MLSSVVRRAARPAFRTATRAFSASLSDGENVVVPLIANSLEFTLSSPPPLHQFEEPPLVVETDHLDLSPGKEVEEVLAAQGHEVTDIVGKEMWTLNDPAKYEGLIPQNLEWTEFVDEKTGEWVTLDEFGDRVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL40</accession>
    <name>A0AAD2JL40_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002022">
        <property type="protein sequence ID" value="CAJ1959782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="249" mass="27863" checksum="F05595EE2A3FDFE4" modified="2024-05-29" version="1" fragment="single">EHPTGNCMRYLAFNRLMFQLLLLAILTIGFAVLTDELEIYRYHEEQWADPSSLDIEITRNDWNKTFRTIKASLTNFKGVHGCPLSYTIPATTAIPADPDPSTDYASIEDKIIAHAPIVNTQGDFVATFRTDNTTLWKLLSALFKDTVDWTDIKHCAQTKDGRTAFLDLKSARLGAQYTNNVSAKIERRWLALSYAGPKSNWKFTITPATTSNASSSLPSSMITKNLMSEPEFASSLIRLSLESSTQLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLZ8</accession>
    <name>A0AAD2JLZ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLZ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="406" mass="47614" checksum="C6CA802B64B3DF4E" modified="2024-05-29" version="1">MMEFVTAGFRNFSEFARWKSSCLLHSFLKICLDRVEAARRLKTKGLSDTYLREYQRFVIWVIKNNRMPDPMQRPFRFTTRDNVDKYYIHDFTKREFGTQNSRSRVHQAIQRFWDSVESSFFKDFDTLSPLMDGEAKKFRVKDSEAVEASVIEQQRYYDSIKEDKFGGTDPFKGLKADLLTSTEKMKVMTYILNDRPDWKDIGCSFNWGCNAGLRGDSTRSLCFKDLYISHGFAPGQGRNLTAILRKDDQKSDFTTDRLVGVLRHRHYLLCASFMTSMNVIRILQLRSNEVHFKRPNKKSPAEFWQIPFVDFTKLADEENAMREIYVKTGVESCKVTHHRTHCVMHASTEGLQQYQVSTLTKHMNDKLTKSYWAEMERRSMTVMAGFDMDEAYNVLRTQIGLPLLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMQ1</accession>
    <name>A0AAD2JMQ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMQ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="124" mass="13563" checksum="BC993E001F0EC6AA" modified="2024-05-29" version="1">MVPLATRYYFLLTETPRRPKRRGSASGSMNTVSYAPEITSSGMSSRRPRRGSASGSTNPISSATGSKTGYKREIAALEFLLGIPMKAERDIVHQGWLQQNGMVDMKRNNKKADDAAAMNPALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMU1</accession>
    <name>A0AAD2JMU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMU1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042162591" description="Tyrosine specific protein phosphatases domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="188"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1964973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="298" mass="34055" checksum="8C100A7BB57C5AC2" modified="2024-05-29" version="1">MKGPFQIQRSRAVWLPLLLAHFSTQSAHAFDSVLLDTAASVRRKVPEFPKYEDLHYESDYLRPDNMGMRGMCNWIIPNKLMVGQYPGQSPEPFAPNARDVDNHIKSVVTQAGVNLFCSLQSEIPPQDDYAWVFNGGEIYFPDPYVRREFPRPFKHYAPMVKSYNPDCLFLHAPIDDCDVPKTESALTDLLLELLEAIDKDDRCVYVHCWGGRGRAGLVGACMLSLIFPERDANDILELVQFGYSTRAGAKNMPPGLQQSPQTESQREFVRMFVDQRQRHHFFFTKPTKLSMAIETGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNB9</accession>
    <name>A0AAD2JNB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNB9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71722" checksum="A883558B4C1E07F0" modified="2024-05-29" version="1">MENINDENNNEINHNNHGLGAGAPWDQEEGNGNNIDMEMEDGNDRDANGDLDGGIAVNPDGASNSNRTTTECDLVLYLECEEEISAAPNHPIIRPGATVFIGMDKNTKLAAVFKRFVEFCNDRQKRRDHIEVSDLEFLHCQLLNGSDTAETSALMKNDRIKVRANKSIEREIEAERKRQQRIADAHFFDQMRILLPDKWNKYADIVLDCQGKLVDDKGRNQKVLWTKVKAYTPILQARCPWIYDIIMKAKTDALAAALAQDTALEFTPNVEDTKSVVARVESEMKAVDEDEDDNSIEVMPFNENDAQNAEIAASSGANEIENDDEEDLRFDGCAKVRSDSPVLSSRHRGQSEPLKKDLFKVTVQNHSPEAIKLLLEYCYTNRVVVLGLNAFIVACKERPTGEKGPIPPLPMTKAGHPRYAQDSRPLVSFQVALAGIELAEEANMPRLSLMCEVAAAQLVTSINVVRALSLCASQKSKSGNDLPKLRKAAMDVVLRNGSRGVLELGRTAMFRKALEEPRAIIVPTLLQGTTEAVTRYGKRGQSKRTKPNVSIYSFDELDREDAIKRERERRKRRIESGRAYEIEEYGNDPSLRWKASYDSSGSRKRPLKLMPATRGKTISRSDEHGSKSRRESGSHRRRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNH4</accession>
    <name>A0AAD2JNH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS22390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1966807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="374" mass="40239" checksum="90335EE1E76F713A" modified="2024-05-29" version="1">MSLPMQSLSLKTFQRVASRQTRLFTTAVPGPSSTTGGAGIGNVESQLLPSMNDAELFKHCKYPRTTSIIGAPMTFGQPFVGTDAGPALLRDRGLRNVLTSLGWRVEDLPDLDFDTEQVSDARDPPNARNCSLVAQGTSKLADTVESKLRKGHFPLVIGGDHSVGIGSLTGILRVIPDIGIIWVDAHADLNTPATSGSGNMHGMPVGLLLDHSEENAVDFTKLPGFEFLIDGPRISPDQIVYIGLRDIDPTERLWIRDYGIKAFTMYDIDHFGIGKVMDMAFEHLNKGNPNRPLHISYDIDAVDPLLAPATGTKVRGGLTYREAHFVAEAAAQSGNLASAEIVEFNPSLSDDGGASETLELGEQLIASFMGKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNM1</accession>
    <name>A0AAD2JNM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041998102" description="SUN domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="234"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="67"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="472" mass="52246" checksum="D43BF5FF591562B7" modified="2024-05-29" version="1">MRINLVCLASLLLSIGNNHVNASNDTELPAAETPELSEESLLATLQAAQGFLQSLDAGKEDGLLASIDELVTKSQELENMQASLKERQDSIDELMKEANVMQLESLAERLVETLEKELELRASLDAYVERYGEIIEEEEEEDEEVVDPGEIVSLAELQKRLDVSRIMSQSEKKIQDWAMDIMKDEVEKYKTKLLANSVSKPPDCPSVNEIVQEVASAVTKYSKDGIGLVDHAQGANIVHSLTSATYTPPPDESELLGNSLWRKYIPEDWEQLLPKGWEKWNLGIPAAVYHSLNIKGAKVAPPEAILEDKTTLGACWPMEGKKGQVTMRLAYPMSMETVSIDHVNLNLIPEDMYGSAPKTIKVIGYPACTNKGDECYSMGFDMYDPIDIAYVDYDIEGPSVQTFNTIYARSEGSIEEGEEGEGSCSVDEAQEAACSSPPKTDIGGITLKILDNWGNDDFTCIYRFRVHGQPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU23</accession>
    <name>A0AAD2PU23_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001733">
        <property type="protein sequence ID" value="CAJ1947590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU23"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007454">
        <property type="entry name" value="UPF0250_YbeD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027471">
        <property type="entry name" value="YbeD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04359">
        <property type="entry name" value="DUF493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117991">
        <property type="entry name" value="YbeD/HP0495-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="204" mass="22371" checksum="460FA484564490A2" modified="2024-05-29" version="1">MVRKEGPAGSFFHKVPDDDDKKESDDNPSIVDDEFSELLRKRKKPSRASKPSTINGIPTAQATGFGKAKPGKQRPSKPYTAVGPSGIEKRGIPNSVSHPETDDQGYTLYTDEKTGKKSRVFEALLHYPSDFTLKIVGANEGSFVSEIVALVAEACETEPAKIAHTARSIGKWTSVTCTCPVQSAEMVYAMYEAVDRDPRVKFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU37</accession>
    <name>A0AAD2PU37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="751" mass="83974" checksum="35BCEC70084DDF85" modified="2024-05-29" version="1">MVSVSKSRRKKKNAGEKPKLRRRTNSNRQQAIVRVMMVVTVVSALLIVLTAGKMITRKDSMVAVVPNSGGQTTSTSSTSTSSTTISALPNNHQQIASSKSSSSAHKNKNVNGQHYSVVIVGAGIAGLTAAKTLETKNNDRILDTDDLVLLPGGVLILEATSQWGGRIRSSTKRSITNQRSKSDESHYYYPVDMGASFTTDPKWLPVILSKSGGDDDNDNNGGNTNKTKKGKIRSNAWDFTTTPVSEDWRNNISTSTTTAHDMMRNYSWYEFVQDFLLPSRRSGGDASSTESTTSSTSSSSTSSSTTKIEYNCIVDKIVAMKAASLEEEVERKNGNKKSIMQVSCGSMSVTADAVLVTIPLPLLQEPLDQQEKQREAMEGATDDADDDNDKIDGKPPPQDDIYNDDVDGDIFRKTGLQFHPPLPSNIQKRIHKHKATMLPALKIVFEFKHKFYPDYIDILKMPLLLAREDDDAPLIGSHEPKDLGVNPQRVYEYWADSEVRYDPKVRRPKGAKHYLVGQLLGQPAQAYYNFYYGPTRQNDFYRVSEFHDDMAQHLLQEFIDYMEQVEHFDEFLVRQNYIGYQIVHWTKETFTPGILDCSAVQFHSNHDKHGSKTKKKKKNFNQVGAVPHVNGQLYFAGEAFANLPGSWYHGCGQAHGAAISGKKAALQILHSLQTKKKKKKNDDNNNNNNNNNAAPEEKSDESSPSIMIPVPTENDSSTHRDLERFSILRPEDAEDLKFYAKMNELWKNFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU40</accession>
    <name>A0AAD2PU40_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="280" mass="31949" checksum="FD5A564D43C654C7" modified="2024-05-29" version="1">MVLNTIGPSKLPPRLELTPLLHRAGGGEEKDGEYEDEEDESCFYQDYEPMDHPSGSQRLKTMQRAHRHKIQTTQLRRSPTGTVGATGTTGRRSRKAARQQEASNTNRVPFHTNNPYVTMGFFSYIAYNLTDPCCGTSDWIYDHVGAGDDYDGDFEDVDVEENALFWRDYNPKRELYSLQLQVENSNLSPQKRSYLEKKIHHMSRDPLEFDFDDDDDDASQSDVSTLLTMDESLMEGKMSGMEVAVRKFKQYERSQRYHKSAAAATSAAAHQGNIRTTYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUU0</accession>
    <name>A0AAD2PUU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS13599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUU0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="305"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1952530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="62275" checksum="F2F43F7B8A14D0CC" modified="2024-05-29" version="1">MVRLELSIEASNLKNVAGAFKGTSDPFAVVTQVATTADERPHVLGKTEVVKNNLNPHWAKIFTFDYQLGSPAKLAINIFDEVRKSENKSMGSAVFEVDTLLAARGGTKTRRVRNGGTVTAVIRKSQGEGALRFKMSGVDLKNKEGFLRKSDPFFELVRRDDTAGGATFNTVFRSEDVKDNLSPDWKPASVEISQLCRGNLDLSFYVKIYDFESNGKHKLMGQFETTVNAMVQGAGNASIPVTLKGEDAGTVILHKAELSLPQSEKSSEGGMEERMAQMSISPSAIPKPDDKPTFVDYISGGCQLNVTVAIDFTGSNGDPRQPGTLHYLHQDGQLNDYEKAITSILSILQKYDSDKKFPVLGFGAKYNGEVRHAFQCGTATEVIGVKGVLSAYRDVFGSGLIMSRPTVFHEVMEYAAKRAEQSLNAALASGGQTYSILLLLTDGCVSDIPATAECLKKMADKPISVVMVGVGSDDFSGMDFLDNLGESGVRDVAQFVPFNDYSESPSDLSTVTLHEVPRQLTTFFQNRGIEPLSRQLVDESSVDEEEEPEIDISLDLSSDEVTVAGGGYQCKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUY7</accession>
    <name>A0AAD2PUY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS13729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041969081" description="Peptidase M12B domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="4">
        <location>
            <begin position="207"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1952813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="720" mass="78406" checksum="A7B259DC1D59674F" modified="2024-05-29" version="1">MLLSVSLFGWLLLATHLPVHAQENPKRFRMRGLRNANYEKDKLEKFKKDHLILPNANLPKQKVSVAGTVQANGKAYSLSDLQPFSVYSRDAVIMIDGEALVLEHESRRIRLFKSKGDQGETVLVAKEGYFNADNGGEIKSIDIISQDGSEVFMEALEDGTLVTIRPEDMDQDKLRTLDFGEGKGDFITSQLMDKNNRFLQESCNSFKVVEVAVAYDSTFCAQVAGNSESTARSLVELFIARADTLFEPICVRVRLSYLEGFCSQAQDPYIAAANADNIGCGGPGTRGALQIFQDFWEGSRANVNRDVAHFFVGRDFPGSAIGCAYVSSLCDSLSYGVNQLSFSTNTQLQGSVFAHELGHNMGAYHVSDPENAGDFLMEGRVNSASNGVSSESSNYILEHLNTRNCLSIEGTSNDDTPNPTPEPTPEPTPNPTRSPTPNPTPNPTPNPTPNPTPNPTSVPITPVPVPNPTSPPVNNPTDYCTGHEFRLELQTDQWGEEVDWQVEDPSGNIVVQGGSYPSGENFIEVTECLQSDGVHTFRIMDSYGDGMCCGGYYKLWYDGNLVIAHDGQYADGETVTVPGGQVNEAPAGSPNQAPVPNPTPAPVQNPTSPPVNSPTGSCNHEFRLELQTDEWGEEVSWQLDDPNGNVVVQGGNYPSGENFVDTTECLSSDGVHTFKIMDSYGDGMIGDAYYKLWYDGNVVIFHDGQYGYGESVTVPGGDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXF3</accession>
    <name>A0AAD2PXF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002265">
        <property type="protein sequence ID" value="CAJ1966206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="20578" checksum="CB99B0339B3BDEAF" modified="2024-05-29" version="1">MRYMHSTKKWHLTLSADNLHVMKWYVDASFAVHPDFQSHTGGVMTMGGGAMQAMSKKQKLNSRSSTHAELIRVDDAITQVLWTRMFMEEQGYPIEKNILYQDNMRPILLKKNGRSSAGKRSRTLNIRYFFVTDQVEKGNLTIEHMPNNDMWGDYMTKPLQGEKFPKFWALIQGDQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2C9Z1</accession>
    <name>A0AAD2C9Z1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS81</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1891841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2C9Z1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1891841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="467" mass="52247" checksum="EA9EA79EE9F83A3F" modified="2024-05-29" version="1">MVAESDEASDINSHDDGHDITLQLSPEDMLSPLSQHTGTGNQKQALMKMIAQEMVQAFVDPNQEGENDEALQRKFDNTIKQQRNLRKAKREEKPNSQHSESRPGIPSGSGYDLALEDVDFANETTENRRNRLKAQRWASLEGSECLPEPELRKVTDSPVKPMREKSTSRRGSDFADSVRADSTNTTSVVEDELSIEEIRRFVLENIPRTVRDQIPEEAWGKIFGGVSSRSSGVSRRSLEQASASASESEKNQQDSLELEIGPQDDISMISGLTSAFPDGKSLESKMMSLCSLDMDREDKIEETSESFTVEEPEDSSNHSLERSSRINIAESKERTSKGVAFGTVEVRYYERTGADNPAVTSGAAVGIGWKYKRGARRTLDQWESQRGTPLKSFELVMDRAEREHILKKAGYTQKEIAQVVRTCLKGRNQRQQTVSNLQHAGMEEAVEAAQSRIAKIMRFGKKKSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAI9</accession>
    <name>A0AAD2CAI9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1905274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAI9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1905274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="467" mass="52057" checksum="7F3262AB3EFD3BF8" modified="2024-05-29" version="1">MTEESPPLHPKSQRSSNPFSESCRNNFPSLENAFVLPTKGSSGGGGGSSSDDFQSVCSQGSSFLNMSIGAMAALADHMRHVAKYGIDGEKTSELTTSDDTENNEADTSRNLSDEKWNYLMDHSNVNTDGSFAAIFENATGVDISFAATDTSCDYFNTSRVKDLATPERARDIQGIVSTREDEYYFGEEDEEDDDDEEGNRSSPFDQGQEEDCIEGLSRTLSFESLNNVNISYISNAGSEFLRRNNPEDSFQEPEDAFNFLNIASPGSRFHDSSFSSSPKKKPLASRDTTPNFPSFSSRSNQKRYLPPRRPQYSTWDKENATVNRSFGKKNNKIVTKANSPPKPLEKNRPRDFVKVISGGGDDEDDPSPISLAQTTPSPENEKLESLLTGRRKYRTVVPRRVFLDSPQEFPEEQDSFSAFLPDEEEEDNSNHGDYDVEEEFDHFEDGEEGVIFSPVQALTESFEAFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBA6</accession>
    <name>A0AAD2CBA6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1888183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1888183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="374" mass="41066" checksum="EF6B136414E910E8" modified="2024-05-29" version="1">MSSSLQVSTVRSEDPSIDNSQVIDPASPRISAYLSPPRKEPKSSLPALHEQSTECTQSASDDSVFDNVEDTRHTQQSVTGRAGGAYADNSTRHAHNDPTRHISNLGGPYPTRGRATNSQHFPPGTSRLEHSHSTSTSALVDDTATPSKQATNQQGARSSEAAASQATMQQNDTSSSNNKNQRGSIEESLGIDYARFEDEPEEMAAWVIHAALIGFFSLVCLSLILSFVVIQSYGFLTLVFLGFLIGFCIGLAIFVDRTILQKNEKLKPIRNKIASAVTTAKDVIREEISLFKKEWREFHLLLTNGEDDMDGANGEADKDDAYVNVDTTTTVPKKKKKSVIFKMAKPFLGVKKKLFKRKRKQEKTNQSSAAVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBU3</accession>
    <name>A0AAD2CBU3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBU3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1926732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="714" mass="80538" checksum="307F005A386C32F4" modified="2024-05-29" version="1">MAASVEQEIEQVGEAIARVEREIEEINEILKSPTISDDDKTYHRQEKSQLRQKESQLRQKEDRLRQEKLLLIERTPVPNAAFDVTRMVQANNPNEMANRQQELGHLLATLENLERKTNLLETPTTPWVGRKATRNSIECIVESNFSKRQSTDHAQFAFLVASGHVRSGKTRTGIELPGIIDRVFESKSLDQKVLPTVYLKIDFLNGSKFNAQFDTPRRAPSEALGGRLLLSYFDISVLQPISHDFVMGQILRHVLRHNKAEANVVVPVVIHFDEHGEFIADRNKSENNSDGRNFFLKMLQCLGSLATSNDSAVRDWHRAGSFFLVPITTGTSSTDANFTELSKYQVHHLALPVLDTATRKKMAAECLQGNANVDKNQISNILENDLFQVALADTGGLPGLVEFACEYNFQQGNSSPVQHLHLKVAAYVNKKWDAKMKSIVSASLSRIRVSNAFVLMAGTDTTFTVQSALDGGTIFLQNHEIRLAPAVLGKFTNDNDMLHSLILKAPTRADPWTWQSFEKVHLLYLAATMGAMVKEREQFKDISLRTYLRNLQPAGNSYLSQKLVLPLEFQSNNYIEDERQCISNQKIRVTTEDHAHVHLAKAGTPIVDGYLNVKVLGGKRLTIFLQYKHSELLSSNARVNVSHMNEAAQNLDHCLDPQHGWDVEGDWIFVWVTNREVIQDVEAIHERLLWVDSNSLCEHCPLIGERGLVARENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCT3</accession>
    <name>A0AAD2CCT3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1917091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCT3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1917091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="196" mass="21952" checksum="84C49A5F9FCF293D" modified="2024-05-29" version="1">MSDLPTPVVFCGPSGVGKGTLIDLLMKKFPDAFGFSVSHTTRGPREGEVNGKHYHFTTVEDIKKEIAAGKFVEYAEVHGNYYGTSIASVESVQKEGKICVLDIDIQGVMKVKESSLSPRYLFISPPSMKELEDRLRGRGTETEEAIKKRLGNASKEMEYGQGEGNFDRIFVNNNLDETFATMTKEFKEWYPHLKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEU5</accession>
    <name>A0AAD2CEU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">15-cis-phytoene synthase</fullName>
            <ecNumber evidence="2">2.5.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1914845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042112590" description="15-cis-phytoene synthase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1914845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="502" mass="56217" checksum="04A81D53C7E1123A" modified="2024-05-29" version="1">MKISALAISSLMVMGVADAFVSNSRTPVSTVSMKVADVYDMKNQRGVGATSTYLNSLAPMPSKREGKSEEEIQTELSSGKVMEGGKVIDFEAIKGPSHAEQALQTAKDGIVSSGKKYIPPGNGILGINDDVVSEVGHELGQFATPGQIQLCASYLRSKAPKSLFEPNHNNSINREASSFTEEEKKTIDSILRKAYVESGEVTSAFAKTFFLGTQLLPELPREAIWAIYVWCRRTDEIVDAPRDSDEEMLNDLGSWEMRLEALWKYGEVEDVYDLCLLDVLVKYPNLPITPFTDMIRGMLMDVPGLGQERYESFDELHLYCYRVAGTVGLMSLPVFGCAEGFNDQIAREPALSLGVAFQLTNILRDVGEDAEKRGRVYLPREDMAKFGVTEEQILAKKIDKNYRDMMKFQIERAKMYYERARRGVFMLAPESRLPVQSSLDAYGRILDKLEENGYDSLTTRAYVGKWEKLSMIPFSWYRTQDISRSLPLPGDKTIPTLDEPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFQ1</accession>
    <name>A0AAD2CFQ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000271">
        <property type="protein sequence ID" value="CAJ1933452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFQ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="309" mass="34289" checksum="5DEE1019C99AD13D" modified="2024-05-29" version="1">MEGGYQTKEEIGVYGSRVSSNFLESGCGVEWEYSQVTCSDGAGRTGHTFNTNVSYAKILSQTKEYKCNYEVKTYYKWEYSVNVGLVCNAYHAGNVEGQCEAFAAEQWAKSEGTTVQSWLVENCEDMRGRALAWEEHHSTLGLVMNDCHGGMDGKPGLVYNKWWYADTPVDENTDTLQSVHGSLGIETGWCKGSSAYNTRRSHFRAVYSGWIGFACVEFNGNLPQGCDCSYGERVVLSDCAGVTHTDQFVDQYWAFNAASLTDCRIDVRKVRGPNILKGTLDVGGPDSDCYQDTTMNWPGSGECEQIARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGC7</accession>
    <name>A0AAD2CGC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1903183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGC7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041974684" description="Nucleotide exchange factor SIL1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1903183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="57458" checksum="71B7CA93C8839788" modified="2024-05-29" version="1">MIKSFRSSAAIALVCSILFHQNYQHGVWAKEIEVTKEWQLLGENDTIPAGMHVRMDMTTGEKWVKQQTEDDDGESATSTEAAIIQGDGSIQVVPKAENDAESAITEKSKKGEGTYDFNMMHRTLSKLPDQEKERIGGLPELPQSTTSRKITSKERKEFESRMADIWERRQKELKELELQLMDMPKLLKERIKSIQEYLKDPIAHLNGMELDEEVPYGQVSHIVSVLQDLEYQLGDVDMSRDFHTLGGWPLLSSLLSEEVHVPQNKTISRLSRSMETKIRSVQSNAAWAMGTSVKNTAEFSPYAVEPFVMNNSKERTTAIDELIAVVCKPYDDPGSWDIRNLMGKAIYGIGSLLRGNRLAQAHIVKSDGAMRLGKTFEAIASDQLQTLGQKVVQKLLSLAGDIVSDIILHPEMASPDVNTKILESFTTSEWCGATATVLENDLMVAPAAQQTVLETVHILTPYCRPSWAEKMSGMESSIEKMKTGWEARKDTIDADHLDQLNESAKQAIESLKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIA7</accession>
    <name>A0AAD2CIA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23539:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23539">
        <property type="entry name" value="MFS TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="50932" checksum="06F580924E290320" modified="2024-05-29" version="1">MPRRTSSNNDDTSSWRYISPRMAFLMVSMSLGQLGDGLNIFQGIYLVGIGWNESSVGKALSLMGLTALLVQPFAGDFVDRATIDRRVFLTMASIVTAISASTILMVRHGNTDHVLIYASKILEGISSSFIGPCLAALTLASFGPDRFDEVMASNIYWGHVGSVMAAGLAGLVAYMSFPDIKFCFLIIGASALIAIGFVQSLPQGDPLLGRGFRSAEDSDTVTRIDSLSDSETGDNMEKPPSENTPLVGASILEAVVPDMPEAAAYMDVFLDRNTCILCCTGFFFHFANANVLLVLGELMGQEGGGSDTQSRNAIPLTAGAIIMAQVTMAFATQIGDNYTAKGTGRKVLFMAGLLSLPIRCALIIMFSDAGSAFLLSTQIFDGIGGGLMGLIQPLIIADITFGSGRFNAVNGLIASCFGLGATLSNFLGQMVVERYGHIASLTASFFLSIIPILVFSNMTETYGLRGQSRATDSKTQTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIJ7</accession>
    <name>A0AAD2CIJ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000435">
        <property type="protein sequence ID" value="CAJ1934987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="122" mass="13804" checksum="B3732979CF278B59" modified="2024-05-29" version="1">MKTSLKSAPSTEVLINPLSHHRIVSPIEEAKIFILIPEERHTMSSYHNTSIFILSFILLIASTANAVNIPRVLQQQQMESHDQHPPNAIPTIGNFDDLGHHDWMASPSARRNGRATRMNNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIX9</accession>
    <name>A0AAD2CIX9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIX9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042044972" evidence="2">
        <location>
            <begin position="31"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="240" mass="26684" checksum="81E85F0C8F8EF16E" modified="2024-05-29" version="1">MPDTSKRHNVYQFLFLVAAICLNLPPVALGIMGCMEWCGYFASWLAANAALSATNAIAALYIIQRMRKAEAAGNEIASTAIDSQNSDSNQSPADELPAANIEQQGSAPQVDNTLEQLHNSDQSQQINQEEQQGTCCLCFVHTSHSTHLRHLIRYDGFVSTYCIFVIFWLFWLSDGVERVIHIDKADADDLENCSLFHEHNVLYSFCIGFVYLAITISSLALLHLPERKTRGTEEKAVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ28</accession>
    <name>A0AAD2CJ28_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS3975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000347">
        <property type="protein sequence ID" value="CAJ1934634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ28"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1934634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="142" mass="16017" checksum="A82FA62455269D78" modified="2024-05-29" version="1">MSTEAEWGEMFKMMDESGSGTIPAEKFPGCVRGAGLYPTEANIKEMLEKSNGASGKVTYDDYMTQMRWLANKYPIDIDQVGESFKMFDKDDNGTISKSELQHVLCGMGDRLNAEEAEEFIKEATIDKNGNIKYMDFLREVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJZ5</accession>
    <name>A0AAD2CJZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS4378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041970366" description="CBS domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="132"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1935041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="207" mass="22136" checksum="5E3120B2E0128543" modified="2024-05-29" version="1">MTKLLLTLIPLLLASSIDALATGGASQSRVFVGTPTQTDPRLVKDCMTPTPIFTLQTTNTVNEAIHDLLQRNLNGAPVVDEDDNLVGVITAFDFLAKENGGAVLPMQGSKEEMGRIMNVARKIVATTVGDLMSPEPITIHPHSSMREAAALMSSSRTHRLCVVNDDGKLIGTLATTDVMQDVLKAVRQALPESHGDPQDESVSELLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK89</accession>
    <name>A0AAD2CK89_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000616">
        <property type="protein sequence ID" value="CAJ1937220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK89"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041925767" evidence="1">
        <location>
            <begin position="17"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="307" mass="32174" checksum="7D34093E258A54E7" modified="2024-05-29" version="1" fragment="single">MRILPRLLAVLASCSGRSTLMDASGSLRLKTSDAKTTSQGVVSIVFSPDTKSFLTDSNEILCLESTDPPCLVCRGATLSGTSVAEGSALSTSSVVSDAILVDGITHGDVEAGWSNSRHARTITALFRARLSLDSSSKQLLILCIHGEIGESESLRLKGEAKSLFDATAAEVKSDAAFIEMYDVSVVSVDSKSDANAVLSKAFQHAGAIAGTDTSLASALEEAHNKVIRSGVAVAAKDPPHIAQAFVTVGNALTKQTRTVRAKVVAWENRISRGLWVEGFGSEAELVRQRVLASFDSETLAAAGLPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKN5</accession>
    <name>A0AAD2CKN5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000635">
        <property type="protein sequence ID" value="CAJ1937353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKN5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26467" checksum="960D13BC58951C30" modified="2024-05-29" version="1">MMLLAEKQFEKTIKGCIVYQEWLLREDTASPTALQEAITTTCVIDAHKGRDIMTLAMPNAFIQTYMPDAKEGEDRVYMKITGMMVQILIDMAPEYREYVVLENGKRVIYVRVLRAIYGMLQSSLLFYNQFQNDLEAKGFVFNPHDPCVANKVVNEKQQTIRLHVDDLMSSHMDPKVNDEFAEWLNMRYGSIQACKIVRGKIHRYLGMTLDFSVKGKLKIRMDDYVKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLB8</accession>
    <name>A0AAD2CLB8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLB8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="555" mass="61252" checksum="4B4BC57871E3188B" modified="2024-05-29" version="1">MRCYPSRTKKKSNTSDVESDGQFLDVSDDDHQDDLDRINEMIAEIEEAKLKKLKAEKARLEAKAASRSPTKKKPRATFQQKVPIARKKKLKGATPKQVTIEEGNNTLKSPPKPPTTARILEPELAAVEAQNNQPILQSVLEAIHPYFVKLQGSADKMSIAARQMEQEQEEARTRLAATNMGQEQPPPSGPTLVDGTRPLSTNPTHLSASMSPAILEASPRPAFHEAAIKSYQADSSKGNEEEIHGISITSFDIDRAMMPEGLKNAAIKGLWGRASDMAALPGKCSPGGGDSESGGAGEEVMNQLLETFGSDSTKIALLDMGYCRKSCHGLGLITSSNKLHEACQKILKKEEDTFKNQRFQFLHYLVQLGYSTEFVEDYVERGLMPRIIKETYINFLALLNNKIRHKDMGADEAWEDSEAYVILQVHSENLLDIRTNSNTTPSRRTNIERVNKTNQKLQRELESLPAAKGRGGREPTKDKNKEGDSTLKKCSQCKSCILHTALKLEHNKTVCPLAGHAGSRGKVVAEQVATAVLATKERPVGDIIKEVSDNWCKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNG0</accession>
    <name>A0AAD2CNG0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="449" mass="50836" checksum="5D46535707918BDE" modified="2024-05-29" version="1">MMNASARPEYLILEPGPRKHTKVVRSVSKNDDIIPRFAFQHVFCEDRTDLFIREGISTIEKGAFSKGRSLGNVHCPNSLQVIQKDSFAGCMLHMQSIELPPHPISFGNTVFSGCIKLRNVAIHKGSRLGRGVFKGCHNLEKIFSSSEEMVSALTDRFEKLPLHQLCYSHSFSSLKETIQQMEQAMISCTEVATSQQDCLGMTPLHILSHSTVQHISLYELLLQRDPSGLVVPDKWGSLPIHYALENRAPPEIIRYLLRVHRRLNQPVDYRYFLLVHGADFFETTTMETVQIILESETIEEIDWSLWIHSSNCSASIGIFRDVVMRSLQTRLDNLESNQWKEEIVEKIKNIPKDCLQMAPWSSTPYSQYQPLSTTILSSGIEPVDQIVSKLSLYEKKTVSHLLELAAWKLKVDTETTSGNMPAEEESLRQNCLVHCGSDCIISNVLASSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNS5</accession>
    <name>A0AAD2CNS5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000813">
        <property type="protein sequence ID" value="CAJ1939572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13369">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13369:SF3">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="358"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="665" mass="73911" checksum="FB471CD6AB9EF37D" modified="2024-05-29" version="1">MYGIHPIRGCYTNLAICLIGAIIIIHPSHAFFIVRQQQQQQNRHPEDPTTVRLTSSFVGMGRTDLCLRPHLNLRNQNHRQYPSLTSLLLRASSTAISGDDDILNDDDDDNVSPVDEESADDINNADKDDQETLLLVHQFVARVQESIHEQTFSSLVLRGVPKPKKAKSKTSTTTMESSSTLGSTANSLRGVIRQVQGRLIMSKQKNTDEVLLQLTWKYHGATDICKNLNLDEIPEILPQLILEAPSVVVSEWGAEAIATNPIQGAELHTLTHVVDLQLAGGGGNKKKNKPKLITRVSKKTKANKQQQQQQGQQQGQQVIVPTAHDREKQTPLDKRADFLQALGVTHANGKPKQGMKSKLRQCQKFVEIAGRLIDKVVEEGADSDDSDDSDDSDDSDTKRKQRPISVVDMGCGRGYLTFSLHSYLVANKQYAATRSRGIDVRPKLVEEISGIARSLGKDFDGLQFEEGTIEQFVAEVEEKKINEDELRVLIALHACDTATDDAIWSGICSGASLLIVAPCCHKQVRPQLNSHYVAESQTHPLADVLKHGVYRERMSETITDSIRALLLEAAGYKVQVFEFIGGEHTSKNVMITAVKTGRVSKDWRDHSNNKEMMEPIVKRIQSLAELGGIKQQKLADWMDIDLGHLSSASKAKLRMPHQMPPVQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNV5</accession>
    <name>A0AAD2CNV5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000458">
        <property type="protein sequence ID" value="CAJ1935356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNV5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="216" mass="24365" checksum="EF189BDC2B960185" modified="2024-05-29" version="1">MKDEVFAQGLGLQVHIRTKIVGYWSYIQSIAIQIGDDILEIEGSADTEEGDDDGAHPHYWSNYEYQGHLENVAGFPVTQELSSTASYKRSYTIDFSDKYSTGQNITVETYKEFVRVRFNGDESIFGNTVGLLGDCKTGKTYARDGVTGMEDLVELGDEWQVLPYEPRLFHESSHPQFPDKCLKPEGERNARRLAEESPSVGTISMEHKQQSLARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPA2</accession>
    <name>A0AAD2CPA2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000193">
        <property type="protein sequence ID" value="CAJ1931985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPA2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="142" mass="16446" checksum="A2C25C797853A24C" modified="2024-05-29" version="1">MKWMINASFAVHPDFKSHTGGTLSFGGGAAQVMSKKQKINSRSSTKEELIAVDDVVTMILWTKLFMEWQGYPIEKNILYQDNKSAILLEENGRKSAGKRSRAINIHYFFITDQVQKGNVKIKYWKGRRHQKDKFPEKSQEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPM9</accession>
    <name>A0AAD2CPM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS7782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPM9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="341"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1942108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="510" mass="57043" checksum="CA0259FCCC640976" modified="2024-05-29" version="1">MLARSAVRKVPACLKPRNVPTSRTKATNRAPINQIIVKHSEIANGSLKRKAPACGWRKTIVSSSSSSSSPSFSSVVDDDAAGTNTNTPDEISIGKERFEKLEVDMEELQKLAAMRCTPLSLADMYKYAVDFSNQEQRLRNAQFLHKELPIRIAQRAVDLLTLPHGLSDAHPVQQIAHMYLSYLQKFQEFPVPTTPEEEHEFTDLLQKIVVNRSSIPKAIARGVDVWRKNHGPAELQVVRLQQMEEALYRFFTARVGLRFLIEHHILTSPHHASRSLLQKSHPSMSENEDMFGCIQTDCDTIREIKNVVETITILTQDLFGICPEIQVVDATQGEHDSKFTYVPHHLQYMVGELLKNSCRATVKRYLESEANGETIQMPQIRVVVVKGKEDVTIKVADRGGGIPRSQMSNILRFAQSFSTEDDNKGSVLDFDSDDEVTGTTNLRGFGLPLARIYARYFGGELTLKSMEGYGLDAYLQLPRLGDSCENLPLPVKFSPGELNSNPPRRVGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPR8</accession>
    <name>A0AAD2CPR8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thiamine pyrimidine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38360:SF1">
        <property type="entry name" value="F12P19.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38360">
        <property type="entry name" value="OS03G0120000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53807">
        <property type="entry name" value="Helical backbone' metal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042107522" description="Thiamine pyrimidine synthase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49235" checksum="C843D71B074E17DC" modified="2024-05-29" version="1">MKLSYHLLLLALLQSSVNGNNSQQCVTSVDAANDYFPEKVQPTESEQWSIEYQNTYKVLTNSWANKTYLLYQCGTEPPQNENQYDAIFSVPVQGISLSSTPQVTFIELLNRRTSIAAWVGSFGFIHSPCLSKMIDDGDVATLQPDDGTNATLLTDSGLENTVFFAGGDTTYENEVQVHAYEENFNLATFEWVKFYSAFFNLEKEANEIFDATKTRYDCTVQNAGILSADQEKKPTVLWGSWCESCGGWFVAKSCPEYYCEFAESCGATLLTTEAGSVTTSWGVNYMTTEEFVEFGKDADHFIYTATDVLSTVYGTFKDDFANMKAVLNNEVYDTAGAGPNSWFEQRLAEPDAILQDFCTIVGTENPAVLHKLSFLRHVDDVVPVNGVCADIATQLEPLGTDCEALTDAPQEGNDAPADPAADEDTKEDSAPGAKFVLGMVGLLAAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPZ6</accession>
    <name>A0AAD2CPZ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="358" mass="38425" checksum="DD2D02B043429560" modified="2024-05-29" version="1">MREDSRKNDFYMSWSSDGADSSTSTTLPHVMKGSSSDDVVGDIVTPVSPSEAPSSPAAQVDFYTYSGDDEEGAVGELVDTKSEAKSHRWKGLIVILLLLALGFGLYILFRNEAPGTKDASNPPWNPADMPSGAPTSESETVMPSLTPTTPPLYDPPSVEDCIAIARGKVIDGQDEMLVERYEVVLDVALDSGGIAIQGILNRLVAETRQIILPEILGCGDASRKLMEIESGADDNPSASSAIVSMIRGSARRQLSLPTSPSSRFIMANAAVSIRNPSAEWCASGSGPLCYRVIMSFDMAFRSDDLKVLTVVQYIAEAFKSPDSLADKLLLGSPFQNIFVRDVYPAFHTAIPTLSPSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2024-10-02" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSJ7</accession>
    <name>A0AAD2CSJ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001247">
        <property type="protein sequence ID" value="CAJ1944795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="530" mass="58728" checksum="52E6D4E44FE5093C" modified="2024-05-29" version="1">MQTFPPCTLDAILQVGRSALTTVKDLPLELLRKTSSSPTTSTLISLVSAKTSSSPKRTDLLTLMAPMVPSGKSSALSSTDPPKDIHWPSGDGVFTKVKKFFPIYPGANIPPSLKLSTAPPSNLESFHPQFRLWYKAMKYLHDHNESQSLHSHAHIFSADTIPTDRFPDSDLATHLTYSPSTVSAFAAEVLTYKALFEEFKQHLALSTLASTNHVTTQEAPAAPLPAGAPFDSKLFAQIMANALKGANASTKEKDLARTSASAKDSFSLIFGRVKPVIQLDGSTVNEFHPSVLTDDFVTFLEIGSIKEALRHLHDTFAHITDTLTTRNNYDRNVNFDIALFQHATVTALKTCSFGVRPLTMHPHKATSLLSLLAWLPPNKNDVRYTTFLSEGRDIIRQEAMEEDKSKQAAXXXXNKNDVRYTTFLSEGRDIIRQEAMEEDKSKQAAKKTDIFVHGDISSVKALIKMLANFFAFVKYCVEDFTFDDPPLIVTLLEDFMNALHTPAAKDWIRYNAVVPHLPLCGSRQKQNDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT88</accession>
    <name>A0AAD2CT88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="73"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="641" mass="75358" checksum="27544FD31B5339B7" modified="2024-05-29" version="1">MATNKNKLTAILMAFFQVVRLLLEILFISTDPRPETFSGNHESRKHSRSSDGDEKKEEEHFSNSSDNQAALEASFKYFEIDNPKEATREAVKKKFRRLSLVHHPDRNNQSEESVKEMQKINRFYELLEQEFDRKEGKGGLFNENIPEEPNADTTEADPDEPGISDEERKRRRKVQKKQRQRAQQREKKEQERREEEFERRREEMEEEMHRRREEMEEVMHREWEEARRKMEEFQKKQKETKQQNKSKFYNSSLNTKKGRMKAHQTWKSKIEALEKEEEGTNNGSSQMGARSKPPNSIMECSTDDIAIALRLGATDVAIELVQESMAECMQQSLRDRARKGEMIGTFPYLAEEDTLKFNYEVYVNVLQSRLDADGNHALHYAVYYEDNEFLTYLTHQAHRLGYFGEYVTSTSKHGSKVLDFCVGSSNPGFDNRVKAFYEEGCKMMQEKEEAEARSSSVILSSRYYFQQLRQHANLDPAFFSVFGILLGKYIFCGRWYETILAILFSRFMEIAKDASKHEQYYVLIFSHCYWFIFKSTVYFTWKLFPWWLILGVTLVAGYFFSLSEVIFFVPAMAHHGSSIIVKHALNLFGYFVPTPKSPRLALMKDVIVMCSCILLLRYAWSLLPKWNCVESWKEEANSEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CX18</accession>
    <name>A0AAD2CX18_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000860">
        <property type="protein sequence ID" value="CAJ1939866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CX18"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="174" mass="19987" checksum="91B9CEA9A898C477" modified="2024-05-29" version="1">MQSDLVSSRTVLSLKKQSIMPKQSLDLTPLHCYNFFSPPEELYQHNRSITVCIDYMEIENAKFLTCIDTTVRYRSCIPVQNLKTDPVFEALDKIFRRYNKAGFQVKTIKCEWAFIPLTDDMLDNMGATIDPTAAGDHKPTAEQNNRTLKERVRVLLAQLPYKVVPKVITECLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CX94</accession>
    <name>A0AAD2CX94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS6891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CX94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042231987" description="EF-hand domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1940140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="438" mass="48909" checksum="25FB46A61D4541B7" modified="2024-05-29" version="1">MPAIKHLLFCILIPCSVFAFSNRGYPIRPFKLSPPQTKNFNQINNFSLTTATQKSLTFVVRSSADDSQEESSSSVDDGQEEQTSQGTDIVNRFITSFWFAIAAPYTDLRRLLPKRERDPQKMTLSLTVKDGVFAVIAYLAIGVFAYHKIFEKWSIVDSLYFTCVVFSTVGYGDVCPQTIGGRIFTCFFGFTGIALLGAAIASIGSKLVQVETETARRAERESRKRFVNMFDKLPKLVKADKEEKARIMSDVHAKNRHAPHLPKAAVALLKGARWIAQSLMVVVLGGMLLGKVEGWKMADAVYYALITASTIGLGDFAPATKTGRIIALLLIPMSVAAFGEILSNIGLAWISSRQKQLFDSQLKTGLTMDHLKVMDNNQDGKVDREEYVLFMLLEMGLVSKEEVAELTDQFDRLDRTGTGYLNQYDIMLVSRLREKHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CY77</accession>
    <name>A0AAD2CY77_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-L-rhamnosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CY77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042132444" description="Alpha-L-rhamnosidase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115212" checksum="60A3CA31DEBF82D4" modified="2024-05-29" version="1">MSVTRQQLLALFLPIILFSLRYSHHNRTCRGNPFQHCDDTSSSLRHKDLNSQLDCANSSYEAPEPFDFLHDFCTDCNPMVDHSPDPLVAMTWGPNVDDLQLYRIFEPAQVQVEAVDDKCRVDLGKQGLSSKGTISIWAKQNCTVRIDWGVERAAWLELISHSQKRSSSDEGYGDHSFQMQAAVSEFNRPYPGKTMPLEQYGNYTYRLETNANFYEGVRYTWLYITFPSTKNGKEQDVDVLQQQQQQQQQQQQQQQQQQQQQQQQQQPRRMKHTQNQEPNELIEVVSSISLVAKVKPVNYTGFFASSNTELTKAWYTGAYGVRLNMDQDYFNSILIERGDRVAIQGDGHPTIDAALVAFSPYQLVANVLNQTDSGNHPVVDQQIMAYPLYWSLSAIHYYMASGDQDTFDRLIPDIAKILDARIQDYLQPDLDMGWMGWDDRIGNGWCFHARNDKCPREAHLAFAGLVAMVCQHFYQSLLLSRNQPFLTQKYLGLYHRLGPKLVQVPEWPSKLGVHAAANAINSGFASSSDIESWMNTVLNDAVTICSFSQFNQYWILQALGNAGYMEHALASIRLCWSAPMALDKGCFWEQSSPDWKTFMKDGDVAPTMPSYCHPWSSGVTAWLSHVLGGIRPLQPGYQRFLAAPYLSQSYPSVAATIDTPTGPIAVNATLREVKVDGSWSYNAVLTNPPTLHGYFGIPTSILSSSNRPVAQVSKVQVNGKDATLLNATFIRNSKGFFPLRGQANNNSSMGLLSLFDKFQYIPIPKTTDRGGVSRVVLAATYLSTTNSDIESQRLRQESESFSKYAPFPEPSYPASIVRVDRTSGGDGIYKYGRDGYLLLGCNHNQNGMNATDEASSDVLKLPSYIRNATVLQHGYPGWIEPSREFVIDHDAHDTKAYLPECMPGKRSLGRVGVDGIGGEQPDLNSILIHVEVADTDGEVEGGADPVQVSLYFVAKTKSDKFAIQVMDLESLNNIAQTTAMDDYKGGVWWTVQYDKSMRLRLSNMQGLHLSGIGFSRRTGGATDRTIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D031</accession>
    <name>A0AAD2D031_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D031"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="304" mass="32825" checksum="A643895891DFD7C4" modified="2024-05-29" version="1">MITPTAGTKTSTSIEPPLESTLDTGSASSSQSKQRQISVSCSTNEEQWQQRQSSEKVSNTAITANTIATQQSTKVTPPPPTSKRIIIPDRHPSTSDHGKRLKVEKSSSADDDDNDNWHLVAAASGQVGQALAKVLMYAVDPIRIQTDLRQNVEAFVIHFRGGKKALLAKQEASTTTTTTAHDGTFHTLPAIIVAGNLKHLDSVVEAISQRPKEYAQTEQDPQELPNRRALLIVIEVQYGLLANGKAGVAVSGDAAHLGFVIHLLKLALKDRKDHSIATSSLSADLALLDSPKKVEKFFKAKRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FAG7</accession>
    <name>A0AAD2FAG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6816 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS59</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1890959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FAG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049213">
        <property type="entry name" value="DUF6816"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20670">
        <property type="entry name" value="DUF6816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042121748" description="DUF6816 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6816" evidence="2">
        <location>
            <begin position="140"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1890959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="369" mass="39864" checksum="B4B5B5042CF2A441" modified="2024-05-29" version="1">MKPLKLQPLLLLSLVVSFIINDGCSFVAAFQQQPSSFRELASSFSPPKACVDDRISFAGDYMEESAAASRRQFLKQSVLLGGGALTSTICTPQSEVAFAASDSSIFPGSSASSVELESGLLESRVMEDLLSPPTYGLEIPDIYYPSYFAGVWGTSSVGTNVEAPCGIPLFGGNRTYAAAKNEIGETNALKYRARFVTSSDRDAAIADREFNVREIAKATMGANSVVDVPLATPNKFCCLLAPAGSPNLLTVDIIALARRQENNEKTFDCSEVVRQIVAPANQNKPQAGIPTAGTNKGGVPTLLKEIETVSLYTPGPLINGQVQTIKCRQRTATFLLPSQDDPVAYQMWQMTRGRPIDVRFYDVTYTRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCF6</accession>
    <name>A0AAD2FCF6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS693</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="14">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1914643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCF6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="17">
        <location>
            <begin position="57"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1914643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="279" mass="30727" checksum="9891F4A207902E69" modified="2024-05-29" version="1">MAARLQGLIRSNGLAAGAAAVAAASTAKVTFLDEDDVVHPPHFPWRHTGYFSSFDHAALRRGFQVYREVCASCHSLHLIRFRELVGVTHTNEEVKQMASDVDVMDGPNEEGEMFERPGKPYDTLPSPYPNKEAGRAANGGAYPPDLSLMVKARHSGHDYVFALLTGYCEPPEGKEMMPGLHYNPYFPGGAISMPPPLSDGGVEYDDGTVATISQQARDVVQFLHWTSEPESEDRKKNACKYLTVVAFMALSAGYYKRWKWSPLKTRQISYVKGIGGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCQ7</accession>
    <name>A0AAD2FCQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1923632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="54005" checksum="405F707C5B2AA978" modified="2024-05-29" version="1">MDEEIEFDEGDLLAQKEDWMESLRQCAKTSSRDATAIEKAQGIFDEMFQAYVKTDDMALFPGPEVYNLLIETHAYGSDEKGGEEAEMILSRMEDSSVAFVALPNLQTYLNVMDAWAMRKNPEKAEAVATRLNERYAETNDDAVKPTIAVTNKLIKSYGIRGDIEKAESIFRDSLEKEGELKANHKTWVQIMKAYIPQKSGYEQVGDLFFEMRKAFRMGEEEYLPKTEAYNALIRALGYKRNGGPEAEELLFEMIEQYQAGEDDVRPNADTFRNTIAAQLNRRNFSSAKVEQLLQIQEGLYMTTGFPDLKIDTRVNNAALQVMSKTKDARKAIRAKRIIENMKNSGDPENMPTKRTYRSLMSACAFTRGNPEESLETFQVAIETIKNLKEFVGEEPDSGFVGLFLKACSNLMPPSRKRDAVVEKIFEKCCADGLLNDFVLIEFEKAASETLQLETLGGFLEDNVKLPEKWSRNVPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDD3</accession>
    <name>A0AAD2FDD3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS3248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040000258">
        <property type="protein sequence ID" value="CAJ1933300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDD3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050547">
        <property type="entry name" value="DEAD_box_RNA_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963:SF8">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041955375" description="RNA helicase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="9">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="564"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="917"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1933300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1147" mass="126542" checksum="94AABB7083CFA3E2" modified="2024-05-29" version="1">MTMLTRIQLAAITWVCCGGAFQTSEAFSFRPLGIGSSSSSSSSSIQRRPRSSQLASAINNVDWGRKTVLQLQNELRARGLSDKGSKTVLIQRLEALNTVKDHPPNENAEDGLPGSGSRNGRSSPGSSYTASSFTGSNSETSPDATYKPRSSFANNQTMVDMESDEARRIENYLKKVKQQQKIRQPRQQQQQQPPRRRPPRPTQQQQQQQQRPPQQQQQQQQQRPPQQQRPPQQQRPPQQRPERNAHSTSYGSPGQQLAADPFMNGRSPMQPIPSSSPQQRPPRIETIIDVTSTATYAPRPPPPPSVAQHRNEDDIYNGAAYASSQQNSWGRDDSYQPATRPPPRASPPPPPISSPPSNFGEQTVTATSSFSQPPPSPPPSPPKWDTSKKGESRAFLSIDKDDFLTPYDAAVEMTADGAAPTEEDPIEQEPIVSETTEEVFPPALDKTADDKSILDKNNVIEVATATVKASPPSPPSTADEMEERANGMNEVNGINGINGMTFPSKEIETETMASANGSKSVADLDDEDDSVPKEVSFSDSSQSEEATTNGETEEEGPWTRDEPYPFEVLGVEPGASMSEIKAAYRKKAMELSLADDSEEIAEKLRQVVVAFQVLSGGYKKGKYEQEYQMLQRLQRRQEKKQVPETNDDGTSNLADLLPAHMYEQVSLRFNCTEPHLLQLQKACYKAIVDGEDVVLNAPADSLEIVVGTPARLLKYIMMGVLDPAGIKTIAVDEADGLLDHLGVIEDIFVSIPSDDYQKVLTSVEMPSELLEFCEENMGLVPESSNFIIESNSKTLLDSQEDIEDDTSDETEMDFEEFVEDNTSDEPEIEVEEGFEDNTSYEMEMEVEEGLEDNTSNEPEMEVEDVIHNDFNDEIITVEFESVQASEVSVELNTAVLAAMDHWHTATRPADRPILSLDIIASMSPIPKVVVLFVPSDDDVESVATELEIFHDTLVKTLTDGSSNDYHAQTLDSIRAHSESGASGTMILVASDAAASGANLPPADLILQYGIPRQPSNPNLYDANVYMARVQRACGDNKDTQAMLLYDYEEEGRLLPGLQTEMEVDSDIVLKPRALPSPHHTLEASYSRTKSYCDKLDCLPIVVDSFEKQLKAELAGMDDMDREDELFHRLAITMAALSDPSKLSKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDX3</accession>
    <name>A0AAD2FDX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS3843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000008">
        <property type="entry name" value="Fe-S cluster assembly factor HCF101, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042012976" description="MIP18 family-like domain-containing protein" evidence="7">
        <location>
            <begin position="31"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="MIP18 family-like" evidence="8">
        <location>
            <begin position="66"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="9">
        <location>
            <begin position="481"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1934503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="62798" checksum="B110AF719B3AB341" modified="2024-05-29" version="1">MRTNPRQFLHSLAILSPLCLLYFGSTPTDAFAPTLWQNSKLSTMQLYADETNEKDLPGIPTEWRGEVLQSLKAVIDPDLNQDIVTLGFVQNLSLDEDTREVKFDVELTTPACPVKEQFQMDCQKLVEDLPWTGPVTVQMTAQPSVMETSTFGMAQVGAVIAVSSCKGGVGKSTTAVNLAYALQSMGASVGIFDADVYGPSLPTMITPDDDIVRFVGRQVAPLQRNGVKLMSFGYVNDGSAIMRGPMVTQLLDQFLSVTHWGPLDYLILDMPPGTGDIQLTLTQRLNITAAVIVTTPQELSFADVVRGVEMFDSVNVPCVAVVENMAYYKVEKENQFDMDQLKEAIGETLEAKGMLNGDEGDKTSKEKKKEKDALVDELVQVVMKNTKEEKIQIFGPGHKRRLSEQWGIDHTFSMPLLNQIASNGDSGTPYILEHPDSEQASIYKSLAASVVTEVAKTKYRQQRPSIVFDEDLHILVIDEEEAMTTANLRRACRCAACVEEMTGRQILKPADIPESVKPLKMAPTGNYALSVDWSDGHKSLYPYRQIRSLLDEQNEEATVEGKKEVAGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG67</accession>
    <name>A0AAD2FG67_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS1337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000025">
        <property type="protein sequence ID" value="CAJ1927684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG67"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="194"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1927684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="579" mass="63111" checksum="2CE48EEAD608ECBB" modified="2024-05-29" version="1">MKPPIASQLVTLAAACASGSSPAPPSATTASTGPFSSLPISSSFQVPCGVPFSSTTTEARAGHGEGVDKSRSPNDWSKALSYSPVLPLRGGASSDDKRNRNAHENAQAASDSNRSSPEKQAKNASSNQSKNSKKNRSTQSRKREKAASQSKQQGGEKKDEGKTTSNNDASTSNNENSQSYPNQRIVEEIVKQTDYYQILGIPNHKKGSLTKVEIQKAYRKRAVQVHPDKTGGDRRAFDKVAESFDVLSDDSKRELYDRFGKQGLGNGGASASGMPGQFQDIFQSMFQQGGQRQSYGRTRQNYTMRYQIEVTLEELYNGTTQDVLVTAPTTERRRQKSVQVNIPKGSIPGQSIVLSGEMDFANDIPGDLIFVVSQRPHPVFTRKGHDLAMELEISLEEAICGLQREIRHLDGSNLWIASASREGNDAPHIIQTGEVQVLKGRGMPKKSKVEDEYGDLYIQFRVEMPNPQRRGGAEALSNEEIIELGRLLSKLQDGGSNKKKLPKTDDKIHSLCTASSRDFGSASGPVHLEEDEHGHHHEDASPFSSQFFQGASGGSSFYFGSSFGGRSNDDDGNVQCQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGB0</accession>
    <name>A0AAD2FGB0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000703">
        <property type="protein sequence ID" value="CAJ1938334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="287" mass="31990" checksum="0755AC690727B7CD" modified="2024-05-29" version="1">MDGGSSSSEGSSIMSDNNKMQFCQLVAGTPGLVMGAILDETTKVAAEQETNQLLETQQEICNIFDETKSALNHFNDFLCIDWGRLRPGEPVPLEKDLHQYVQLEELTVELFGRYATYLVECNNKTEEKRGNVVPISLNSAIGYFSAVKVAYLEQPVIRNATTLPSVFWRETWSNLNCRMTNRVVERHKTTGTPLVSPKAAATTDDWKALACVCVWNGSQKLLEFWAVFVALVHMAAQVNEVAFLQFPDAKTTLVNGGGNTKNRVGLFSKCEQLQARKWSRDAHISPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHC2</accession>
    <name>A0AAD2FHC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000169">
        <property type="protein sequence ID" value="CAJ1931678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008990">
        <property type="term" value="F:rRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47313">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47313:SF1">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="166" mass="17937" checksum="A08D00AFDDA18D39" modified="2024-05-29" version="1">MVESAVRNSTTGDMNEELQILGTDRNEGAIAISKRNAARAGVDHLVKFRHQAISSNQWFENPSLAPSRTLVVCNPPFGHRISKDTKRKKDPSSSSLLSLIQTLGHKLMKLIGQSAEGNSRRQVAVNILGTNPNLIRRSGIPNLKVSFASKHGGINVFALGQASSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHV8</accession>
    <name>A0AAD2FHV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA-processing protein EBP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS6962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1940278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="48830" checksum="A59BEDCE001F592D" modified="2024-05-29" version="1">MAKKNKKSKQSSTNKKKQPKEAVVEEKVTLEAIAAMSDSDDEDVPESQWNAKAKGLASAIKSGKFDDLLKQMKESANDDDDGDEMEEATLDSSSAEDEEVEEEVEEVEEEEEVEEPKASKSAKKSPQKASDDNEEEVEDKDEEEVDDDEKEEGDQREEEDSDEESSEEEDKVGNAKIKQLRANNVKNSKALSVVTAELVAAHAKLPWAERLDIIPETPLPFGEHGDADANPLDVHDDLKREVAFYKMALEGVNEARKQCKKANVPFSRPEDFFAEMVKTDDHMAKVKDRLIFENKKMEAVAQRKTNREQKLRAKESHANKLAEKSRRKKEHFQQVEEWATSVAKNRGSALQDDADDMYLNRGGPSKKRQNADRKFGHGGKRGRFKQNDPASKNDFSGYNPRGNFPGGMKRTANNKGGADRQGKRARDASRSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIB0</accession>
    <name>A0AAD2FIB0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000316">
        <property type="protein sequence ID" value="CAJ1933943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="130" mass="14245" checksum="22DA6D0A6F30EF49" modified="2024-05-29" version="1">MDVRDHEGPFEPTPSPFWGSPSPPVPTMHDPFARAPSLYHTAPVQQSPFHPMPVQQHPHMTPGVYHMPSPYQPTPPSQYPHSPYLHPTFVPDGMGGYYQTMVNPAAMIPGHPHGGLVYSPVVAKPGALKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIZ3</accession>
    <name>A0AAD2FIZ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001194">
        <property type="protein sequence ID" value="CAJ1944073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIZ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="64" mass="6895" checksum="4593541B49A79006" modified="2024-05-29" version="1" fragment="single">MRFPSFSAIKSLPTDADSDALLKNVFHGSSSMHDRATAVTSALGLMFFDPQGKLTVVTIPKKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ57</accession>
    <name>A0AAD2FJ57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ57"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051918">
        <property type="entry name" value="STPP_CPPED1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43143:SF4">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43143">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, CALCINEURIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="620" mass="69686" checksum="8F8B78385BD6C667" modified="2024-05-29" version="1">MKFPRSKILQLPLAIMTTMMMMPTTVVSFAPSLQRGGKVSRHSTQAIRFSTLLFDKKQNKDTSTTDRSELVDANQWLEAAVSSTLKTGGFDESSFLVGILGDLHIDPRKMEDYEEGKNDWKPIFEAAQQAHGNTCLVSLGDLGESKNCDHNEANPAELFAGTTLCHEMAADFLGNMAEGVPYEVIGGNHDLEGIDEFDTDKENLEVFMKTHGKPTPHFCRQVADKTLLVGLGSTVFRDAPFTSHEVIVDQAQIDWFENLLKTHPADDDWKIFVFTHAPPNGSGLRIIQENHVVNGCCWLNHSNEGQCRKFIELVREHRSIKAWFSGHFHLGQDYQDSITFPTIPMEEGPYPNRGSCVFAQTSVMRKGTARDGRQQSRLLRGNKDGFEICTVDHQAGGKIRLDATITYRDNSHEVGIYMHDDKAYEHDNYFKVYQPTEGDLQFVCGADTDEVCSITDDDPVTMETKAWWRLSSNRVLGVLNGMLLEYDQSTLAPLGLVLTKEELLGKSITVVDSGIEECIVDDFDDENEGMEGAEHCIKEREQAVLVHDLETNIVTIVQPNEDGSYWRKIVRNKIARMKEKRREQAAIQYIQERAGMDDKEAKKSIQSTWGPYTSTSGNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK78</accession>
    <name>A0AAD2FK78_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001294">
        <property type="protein sequence ID" value="CAJ1944997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="415" mass="45001" checksum="8C24BD55C68D0C51" modified="2024-05-29" version="1" fragment="single">SRQRSPRANRSDDNRRAGLSSSRHGSHRSLRSEEDRLAKRQARAAGSDAGKPGAHTASNADERSLARQKNQADRPPKTNRSHEDRLAKDRARSARFHTSNPGAHTASNGDESRSDRRKNRANRDRDAKVRAKNSATKSSGNGAGSDGVVDEVERHVVVDPIKQRVDHTGAVELKAMAIEDVANEQLKEQQAQIEALKRQMQNMAQPNHGSDPGTEEDSDVDGTNAANEQYPKKRWKCIAGILFFLLAIGGGVAGYILGTSEKSPTEALQLQVGPTNPPTTAGGNTTAIQLPSTSPSNSPTELQIYRPPSQEDCEAIASGSTLSDQGSFTSREFVIEFDATLNSQMAEEDWVGPLKEQLQSIFLPVVAGCSTRRWLRETKSKQHRQLQLLPDFAIANGKIGDAIVTEGGCEDESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKH9</accession>
    <name>A0AAD2FKH9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001469">
        <property type="protein sequence ID" value="CAJ1945714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="223" mass="25241" checksum="2A244CC3C0BCF94C" modified="2024-05-29" version="1">MQRDDNATRDDNESGDSNTQWNYGRSNNGSHGGQFIQRGHTDNHPRQQGMMLFQHNNTGIHLDSGSTFHLQTNEDDFKEGSLQGIHGGFHYASNVEGREIYREGIDKVFDSVCKLDTRASDNVNSLSNMVQDGFDVFMDTKRENSFFVTRNGTTWRFGHRNGLYSLVDEPAMVTTMFHDHACGLDNNDVQGYCALQSVEKNKEGFTNKQVKRANVAQSGYHMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMZ6</accession>
    <name>A0AAD2FMZ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="672" mass="74096" checksum="863F5E572AB3B3E2" modified="2024-05-29" version="1">MSNQDENVDLVESSGAAEVQECDKTTDIEVMPQHLEASESSKRQSKTTKRETGTAKKTINRRKAANISSDPPGRISSKKGSRTANKGGNYRALKVTCPPPGSDSTRRVQGHDELMRLESRRRLEIAQQMEMYQDRWHVAKDILDFASESVGSAERLINGFIKASEAFASNLRAISEDKYIDTKGEVADTWKAQNRLTKQRDFSDTIDILSPISSAILESQSAMAKQAKAMENVCNQISSNVLAELQELTSTVQGGARTLKIHGGAILAEMKQADNDVTTIWDIFDGLVSNDLIEQSTHGGSMHGASVHGTKVFNDFMDMIDKSTHGASMHGGVAVSSIRGGSMHGGEILRRGNQGKKAMLKRMGGGKDCWLVAQFYKVAVQHQVLAMAATREKMDNLVDKIIALEEKRVSGLHTLLATGFLQRKKALFATFPKFNEIALKDLEGADISEESLDAFFDNRSLERLKHSKSHRSSIMNRRSVLTGFTGPLEIENTIEEFGDPFDDLSQILSSKVVELKKPGALYMMDAEWTMALVIVSKFGIFHVIQAPIGKSITEETSSVQAFQSLRPDMDFGSPNAWKARSELRLLETLTPVVSLDVTQCIFQNSTLQRREVQVLVTGEQTTRNKLFGTSGTVKCTLRLKSPMVAKAFTEALKSMKKSILSPNKAKAEPTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN40</accession>
    <name>A0AAD2FN40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS10832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000002">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001859">
        <property type="entry name" value="PRK00591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF8">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR APG3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042248475" description="Prokaryotic-type class I peptide chain release factors domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1946776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="403" mass="45025" checksum="AB1466CBB8480E76" modified="2024-05-29" version="1">MKFTGLFSSCLLVLSTSAGTQAFVLPNKSILKSVELLAMDIGMESRLDGIQRSYNALTERLGDPDVIGDSKLLQKVMSDRAQIEETVLAYEEYCRLKEESAGAKELFQEAGDDPELKEMARAEMKEIEPQLDELEEKMKVLLLPKDPNDDRNIMLEIRAGTGGSEASIFAGDLVDVYRKYINSQGWQAKIIDESSGDDGGFKNIVMQVNGDSVYSKMKWEAGVHRVQRVPATESQGRVHTSTATVAIMPECDDVDVNIDAKDIEMSTMRSGGAGGQNVNKVETAVDLLHKPTGIRIKCTQERSQLKNKELAMQMLRSKLFDMENEKREMEERARRGSQVGTGGRSEKIRTYNWKDSRCSDHRIGQNYPLSQFLNGDIDPMISAMIMKDQEEKLKELSEESAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP33</accession>
    <name>A0AAD2FP33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1135" mass="128175" checksum="9CC6BDAE8896378A" modified="2024-05-29" version="1">MASANNDQVKKRVSIPMSSKDEATITTYEYTLPGDDDDSFLVDESDLMSSRSGSFKRIDTTGSVFSNSSGSISMSARSTGSSNAQEMTSMRSKSICDDELNLIDRNSVKQKKSSQALAGLTINKLNTSNIGLIGREKQVKILHSCYSTIMDSKKEEGIYAKNRQLVFIKGYAGVGKSMLAKTLEQKVSSTDKGCFVEGKFDYNHSDEPYSGIAAAFGNIFDFIMKDSQGRDFSTITEKITSRLGEDVKMMMYLVPQLDELIGDYSTSGVESNEGAFDPTSAEQRWKYAFRMLARALTSTFHPLVMVLDDLQWADVSSLDVIEYLVSDVENPNPLMIVGSYRSNEVDENSILYNRIQSLLGKCDKFCFKIREIDVPSFDVNDVNKMVMSMLSIDDDEDATRDLAEICYKRTQGNPFFLSEFMLLLYEEKLVEFNLGLMAWKWEASEIDEKTMATANVVNLLQTRMRKMNLDVQNLLQYAACLGTSFTMSNLQLIWKEEGDMQNSNRLTVADFLNLTKQESLIESNGGSEYRWVHDKVQEAALHLSDTVNDAFRFDIGITLLHGMTPNEVEEKLFDMVDLINSGKVNKAAEFAELNLRAAEKARTMSALQSASAYAVHGIGFLPGDHWESHRPLALKLYTMAAEVELALGRVESSEKYGNEVLGQDNMSLMETLPFRLAKARNLCYVQLKFDDAINYCIPILRDLGHNLTWSRKAVPIQAVRSLLRSVKALKQAPKEMWENVSKTTDPKEQSVALLMRQLNYAGYNSEDVFLSILCNARLGEMTLKHGVNQSSASAIATLGGAILMVQQDYETCEQLGTLALSLERRIHGIHIAETVYCAYAYGLSWTRMLGDCVMPAMEGYTLGMQKGDTPFASWNLMQHFVFLPYTMGKALGPMLEEFPRILAQLENVAQSGHVLVLRLFWQMMLDMQRTLQPSTNQLEGEIFSRSKDNEQSPVHRGTVHLCEGELMIFCGDYESAATRAIKKAGKYEKALPGFFMIMIETFHRAVALYAMAQKTKRLKYRSRADAIRKTMMKWMKRGNPNVVYFVEFLTAEHYALASKLDKAEEHYRKSIVFTARTGYLHHSGLFNERYADFLLSKRKDVNEAKYRLEEAIRYYEEWGATGKVQQLKDRLTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPU2</accession>
    <name>A0AAD2FPU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS11841</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1948931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPU2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004790">
        <property type="entry name" value="PRK06136.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041946720" description="uroporphyrinogen-III C-methyltransferase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="13">
        <location>
            <begin position="87"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1948931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="345" mass="37863" checksum="1164952EC276C136" modified="2024-05-29" version="1">MKHFDQSFITLLVLLHVSLLLGLTQGFCPESSCRVSHHQSRQERQLQSSSDDFFGPNTERDNHMPSSYRDLDPLAPYPMDKLENGGKVTLVGSGPGDPELLTMSAYKLLQDPEAFFICDRLVSKEIVDMIQGEVKTARKIPGCAEMAQEEIYSWAHDALSRGKHVVRLKIGDPFVFGRGGEEVINFRRFGVEPKVIPGVSAAFSAPLLANIPVTHRGVANQVVMCTGYGREGSSPDLIQYHEEQTVVFLMSVGRLRELSERLIKLAGFPADTPVGIVEKAGCPDQRTVVGDMSNIADLAALHDIQPPSTIIFGKVVNVLLDSDQYEIIEGLVKSAAKPFAAKFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRV8</accession>
    <name>A0AAD2FRV8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001774">
        <property type="protein sequence ID" value="CAJ1950982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="13989" checksum="2CE6B3A099B8F4A3" modified="2024-05-29" version="1">MANWQVQLDAVRAAEEDVSVASTQSSNIQVGREVAVMHSQAHRGLKYKDSGNLVYLDSNDYKDGKIPEHFDMHDPKWFCLGATGLSLDTALTFHLCKDLMNAKMGTLKELPYMFNYETNVGGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUP2</accession>
    <name>A0AAD2FUP2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041925350" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="3">
        <location>
            <begin position="32"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="845" mass="95184" checksum="D7342ADC88CAF708" modified="2024-05-29" version="1">MGCSGFSTPRLMSATFLFTILLLGNIETISARKHEPKNLRLGGTAVDDTLEAKQISDLPSRATNTTVRELDATGLPSVNESINTEDRFAGGKGLAAEDNNATEIQESLSPELNDVDGEGKDEELEELPPLEELPPLEELPPLDSEADEEEEDANADEVSSNGTDSTAEDVNEDEDDTDSDEDESAVDEIPFVETQNVHVEGLPFGDINVLVVTDVHSHIGGHKHERNRDADYGDILSFYQHLKHFCDENGHDFWFINNGNWKDGTGLAMGGNASSLVPLLNQMPWDAINIGEHELYHQKTVELMQESMIPNFSHQFVSSNVHLVSKDGKKHMVKNYIILKGKKHRVLVFGFLHDLHLPNPRLNIQSVEKAVNEVWFETALREETYDAIMVLAQIDAEDRLINVINDKIRALDIGLDIPVQFIAGHTQKRQHKRVDQWSHSFQAGANLDTIGFVSFPVNATAKAKPKDAEKLFEYAYMNTSAQSLNHILGDLETFPTERGQNMSQSIQDTRHFLGLDEVVACPVQDYHLDKHILGKQSLWGLWQKQVVPNEICKHKTFCIALISSSSFRYGVRGSASTGDEMTVDDIVAIAPLLEPVYHLGKINDYAIQRLNSSLNIDSNQHHHTLPTFVMAGELDEKGDYDFYTHGRDLKYILPELERLFVKDVEPKTTGDKDTLYWLRYAQDTWLCPGMLKNTKVEPWFQNEKALELEKDDVIDLDDEDVEEDEDEEEWVLPDDGYYGYSPGGEHKVKHPGEGLVDKPKGPTSAELLQQRAEAAKQRREKNAKARRKARNIAGVIFGALVLCVPLYYIGRTIVGAEEEKEDFYDRKELKAFKKNKMKPMQIELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV31</accession>
    <name>A0AAD2FV31_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001824">
        <property type="protein sequence ID" value="CAJ1953204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042225982" evidence="2">
        <location>
            <begin position="18"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="246" mass="28050" checksum="09506E900FB092AE" modified="2024-05-29" version="1">MPRILPLLLLIATTCNAARPQMFEVESAVEFQKEEEAILLEEMRMMRQTQAKNANVNANANANANVNAVTTPEALNHAAMEREEAAAAVEGDSKESLTETETVLPVVNRNDDPPKQHQQQRQHQTLLRATREAFQREEQEAEQQHTEGTTPSRSRRLRTATTTGPQQLEQQKQQQRTRRTTTYLENLNQKTHSVAIQSFYQTTTEEPNRPLLESTGKRLNKVALEMLFEEELLEEMLEIAQSSMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVV3</accession>
    <name>A0AAD2FVV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS14893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="81"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1954300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="357" mass="39671" checksum="500DDE5E160CF9F4" modified="2024-05-29" version="1">MTTDDSSISTQMAKDLADSLYSCEKHPLFSPKYGAPMTNKAETKAVLNALLNGIRPASANVAGYGPLLLSDIPDSAKESKVVVVGVDEAGRGSVLGPMVYGAAYWSASVEEKIPKGFNDSKQLTEQTRDKLFDQLLDHEDIGFCMRSLLPSEISRNMLRSKPYNLNEMSHDSTMLMIRKLLDAGLKVKKAFIDTVGNAYTYRRKLEGQFPGIEFVVESKADAKYASCSAASVVAKVSRDKFMSGWKFTDELQDVSRDFGSGYPSDPKCKAWFEKLQDPLFGYNDFVRFSWAPIKKKIAESDEEAAVNVLFQADLDDDENDLKQEQQGMSSFLSGSKKHKRARYFEQRTLSVVTSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW00</accession>
    <name>A0AAD2FW00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MCM10 OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM10 OB-fold" evidence="2">
        <location>
            <begin position="159"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="708" mass="77100" checksum="D31D2CCD4D72B3FC" modified="2024-05-29" version="1">MDELLDLMDKEERSPTNENHPQLNDNDDGMDELLDLMDDEYENENAAATSQSQSSASAVQSSNQAQVVTPPPNSLGRPKSSTQQNSQRTTKSKSVSGSVDNKLGIRMMDRQVSSVDLLDMISINPYYTPAVISAMNLNALSRLLVEPPINIDPATVTGKMNMVTVGIVFSNTGTKQTAKGTSFCILEIGNFTSGPCVTVMLFGDAYSKYVRTCGKGKVVAIVNPNLLPIREGDKTRIAVTVNNTSQFHLVAKAMDFGICKGTTRVKGSDGKWTANGNCKNWVNMQVCEFCLHHRKQREKKSKTTNAVGGSLQQLRAEGQLAVASSRFGTAGASNRLTSGLQSVPTQMKKTLADQRKSVVMQQRQQASGSNRFLNGGGTSRQVASSSTLSTQPPQVAAQSGNRLLSGGVPRQMRSQKLSNVTNRANPYSKQSNLAPTRKPKPKTGIVGNATLRGDGDWFEQGSKPKPANSRSGSLAKLANKAAKKRKLVNTDGTSGFNGSVPVPKPSQLFAGGQRQMLSNSRGPKMPDRTKSTTSIMESQARLAKMRQLAEDDKKKHLTGKSKTSSKKGALSSKDSFYANVGDIDLEKVRNTKSKFAREVEAEEYAKSRQKVVELEKLEGTKNAAKKRQDIETKSFTVEYFCKTCGTHSVFLPNSCVNAKHNVKKRRKLAQQQTKEAKRTKLHQKSAADGGLRLGAGNEWARHMKDFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWD2</accession>
    <name>A0AAD2FWD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWD2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046976">
        <property type="term" value="F:histone H3K27 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="570"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1954556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="704" mass="79179" checksum="32CC8BE5FE119C48" modified="2024-05-29" version="1">MSANDPINLADTSSSEEEDNFGDSCTTENEANIYIKGDNGTDATDTKTAKAELQAAKSSDGGEIFREDSGTKLPQRVNIPERASLTQSNDIPPSEETRKKPKLVHNTLVKHDDDGNAFVADNVGSRNTNDNGDSNDDEIVWLGSRASVPKPDKVVPIAELKNSLEGLTRAQVFERMKNDPRIQQTLDSPIAESTEKGRSMEDTIDISDGSSIISVHSLVDVDARVNPEFDDVSVIEMSSSEEEDSDDDEAPFMGDTSFMMTNEQSKVRDELVVEETPELLEEAPTRPRVSIREMAETFKKDHDSKEDEKILVVVEEAVRKVHSKRKQTLRRKAKRFQRKTRVTVVAETQENIKKFPTQSSEKPCLIRGEYLDDPNHPLPKCQVTFIPIKKSTGCFDKHPTELLDVCYDFECMGWLDYKEGLQEQRMIPRYIIERRIKEAEEVVSRVCKRLGTSGELPKVAQSYIATLMNLSAKSIFHIWCQQLKKKATSGPKCVVQLICQDVNSDNLLASLGCQCKSKCLTPNCPCHRAGRECNPDLCKTCQTCTDPAGIPKERKQKCRNDNIRMHRQNKGLFYGKSTIPKAGWGLFCKTEIKRGEFIGEYVGEVINEDEINRRTATGENLDYLFDLGNGHCVDGLRQGNFTRFMNHSHENQNVRAAIMKVDGGPRIAFFARSRIIPAETELFFDYGKRYKTDFSTGATSRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWY7</accession>
    <name>A0AAD2FWY7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001876">
        <property type="protein sequence ID" value="CAJ1955039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="331" mass="37894" checksum="A4346578B341ED6B" modified="2024-05-29" version="1">MEQISYKFKFKKDKIEQPESYLGAGVKRKVLDGQHMWTMSSYDYVTAAVKNVKATLKDNQRWNLPKKAVTPMNSDYTPELDGSSELNAHDHTYFQELIGVLRWATEIGRVDILLEVSLLSQYQAGPGEGHMEQLLRIFAYLDQHPKMTLYFDWRIPNADFSGVKSSYKEFRTLYRDAEEQLPSNMPKPRGRQVGSLAYVDALHAANKKTRRLHTGYAIFLNRAPIVWHSRRQNTVEASTFGAEFIALKSCIEAITQLRYKLRMFGIPLDEEPTQALVDNEAVVKNLSLVESTLNKKHNSIAYHYARWNVAAWVIAVSWIDGAINIADAFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYB9</accession>
    <name>A0AAD2FYB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Plastidal glycolate/glycerate translocator 1, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS16338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001922">
        <property type="protein sequence ID" value="CAJ1956660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYB9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249:SF0">
        <property type="entry name" value="PLASTIDAL GLYCOLATE_GLYCERATE TRANSLOCATOR 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PUTATIVE SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1956660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="52599" checksum="F56E2B8972847EC0" modified="2024-05-29" version="1">MKVLSLLWLSTVSAFTVHKGFASANVRNHVQAIISRPHTRNHRIVNPLDTRGSPTVRALTIAKASNDGKINGVAKVSPPTPTIVSAFLLLALDVGFRRLFQKLAISFPSSLGGCCALFISLLTLPGGEKMFKILSPGAALLAKWLPVFFVPSLVTLPLVGNVGPMSEILKIFAVVVGGFFFTLLSTAGSVVGIRKILSPDAITNGADEGSENATLINEAPKIQPKAFSDETTTGLRLASIATGVAAIASNRLSSSFATPIRALFLLSATLHNFVFGARLPRSFSKVVHPLVTCTALTWATATAFASVTGSTFVSMLRGYKTGTLTPLKCGAGDVLLFLLGPAVVSLAISMYDRRKLMRENLTEVVTAITVGSLGGLFGTAAVARLLSISSPSVRLSLLSRNITSPLAMAIAGILGGDVSLAVAMVVVTGLIGANFGANILDAAGIKDSVARGLGIGTAAHGLGTAAIVNEKDAFPFSAIAMALTASACTCLVSIPALKRLLIQLALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G069</accession>
    <name>A0AAD2G069_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G069"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF496">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="4">
        <location>
            <begin position="213"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1958842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="554" mass="62358" checksum="476C8CE5F933F230" modified="2024-05-29" version="1">MSDPNNNEDIAKLQDQINSLTNQLEAANQANKGSTNSKRRQIAPAAVHIQQVDGGIGQRPFLQSRREMMGRTASICTRQVMSNLPTGENDYSNHPLALRIMDMFQRPSENLDYLNSEQFAKDLFKLCQKVRHVLEGEPRVVFLQSPAYIFGDIHGNLEDLHFFSDNIWRLGMSLTAGNFLFLGDYVDRGMSCLEVTAYLLAMKLQLPNKVFLLRGNHETRDVNGWEEHYGERSFIYQCRQRFGDDIGYRIWEACNQVFDRLPLCGVVDQDIFCVHGGIPRPVGENTTRIQDILNVSKVAGINPPYEHEDDDYQQVASDCIWSDPASEEQEQYSVDPESGFGESLRGGGAICFGNKAVTDFLAQQGFSYIMRAHEAHAEGVAVSKGARVFTVFSTSKDHNQGSQALAGCILVDGEKLQVINRSPAYKNQYVHRRDSVSLNALSPTEISKRIKLGLISQDDDESSEEEWDDFDESSEEESDEEPPVYAFSKERRRSSVNLGEMAARFNSEEWDSTHTSGFVGTSSRHLNALEDVIREDDEEEAEEDSRSTVEGDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G072</accession>
    <name>A0AAD2G072_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G072"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1104" mass="123464" checksum="E6AB1FFCFD35D26F" modified="2024-05-29" version="1">MQNSNCSSSRSIRLDQSSDGGSAKRSTSSNGGADSLSGVTNQTTVTISISDKSSESGSSSALNTTIGAGNSRRSKPKSSTVRDFSKTIRATSDHVPPLDFDAAGLVSRDKELATLKSCYDRLVKDGGKEFILVGGQSGSGKSSTIRSIEKNMSVEGLFVEGKFNMNTSNEPYTGVANAFGVMCRKIIEAGSETIADLRQDLRKELGDKPGMLVQLIPELNYIMAVDTTDDSSTESIGRADEAEGGVDRLRFAFRVLTQVFSAVFSPLILFLDDLHWADVSSLQVLEYLISDTQNENPLMIIGSYRSEEVDENSLLHNKMVALREKTEKFQFHMSELMLGVFGPSDIEKVITAVLPSLRADHIVSLAALCHKRTHGNPYFTIEFIKMLHFEGMMKFDKTTKTWSWDLSEIENETMSTANVVAMMEQSMRKLPEQVQALLQCAAYLGSTFSEPTIELVWSAYGRRLVDTRTKPVSSLLPPLVADSIFEKGEKQQYRWTHDKLQEAALSLSDARRGTFQLDIGKTLYYGLTEEQVEEDLFTIVDLINSGNALKRPEFAAVNLRAAEKARDISAFQAASEYALEGISLLQEIDWIQNKSTALSLYTIGAEAELLLGNVTAAEGYRELVLSRHDLSTLEMLPLQIGKAKALGDVELKSKEALEYCLSLLKKHGCRLTRVRQLAFPQAVASLIRTVKKAKAKPQSFYEEMEPSENTKLKYIGYLLSKVTYNAYTAGDIPMYLLATVKLVDITMEFGANEFSATAFTFLGMMSVIVLQDYEAMERFVNIALGMLKKFRGMHAAESIFAGHQLGLFWVKPPEIGRVAAERAILEGRRMGDLAFTLWSILQRVVYLPYITGRPIHTILEGCSNVLAEFEESKAGANILSLKIHYQMLVNLSESSCENPSWRFGTIYTDTKEDHEGNLIHLGEIIVVEGELVFWNKISEDCEVSAERALQIGETHAKITPANFWNQIESFHRAVALYAAAIKTKKSKYKRAANKIRKRMAALAKYENTTIQYFFMFLTAEHLVLQRKHIEAKLKYEQALEAVGKLGHLHHLGLFYERYSDFLRLELNLETESRYRLEQAIGYYRDWGAVHKTKALESKMKLNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0Q1</accession>
    <name>A0AAD2G0Q1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001991">
        <property type="protein sequence ID" value="CAJ1959303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0Q1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="458" mass="51565" checksum="05F6600239D36BE6" modified="2024-05-29" version="1">MVICGIDNVTLFQGRTQAERIAYKIFSDDFTTTMDSTIDKLNKEFKTLAGLTIAQGQIRLMPAIKKNIRAFIQWCRDEIRMGRDPTTTPFPVVDAAKLLRRMKTHEQYVYGSKLMSQQALPQDFTNNVQWEDWCPTFENYLRTIPGRDGVPLSYIVRMNNTGMPTLHKDFLETYVNMAPHVGEAYVMDNAKVLVLLSKFIVGNTKAEATLQAINIAGNGREAFNALRTHYKGEGIIASDIVEAEHTIKELCYVGEKPKLNWSMFERMLKKVYATCDKHEGTEVHSDAMKLLREKFPQGTSNATDRGRYLGETRADNDRDRSRSQNDGGGNKRRNKEEITLSNGEKIWYHPSYLFSRTHLQAFTNKQRERMAKERAAYRESQGLPARRATGQAAQTQQVETQLAELQAEVASIRSNNVPATIPAKAATQISQVTMGTTGTTAMGGCNQQANNQQASGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1N6</accession>
    <name>A0AAD2G1N6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1N6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="479" mass="52271" checksum="5403F3C92D05F967" modified="2024-05-29" version="1">MPRSSMQRLTIPVPSESSSSNNSNSNNAENTKNQHGVLEASVLSAYDLPRSEAPSHISITIGDIVQDSGPPMRKNRGRNTYRFSGNNNNDNATSSSSNKTTMDDDSGIVRLSAPIPKFFKSNLQVKVVYKNQPSKLLVGDYDLNQLRVWERQWVILTLSDPSKPIPSTAIVTTMDDDDDENESPNSTPTRRQARGGGGDTPPTFRMALHLSAPYRPEISSVLAFSKTWFEMVDKLQEHVEEIWGKLPTLPFDNIYLALPAVPILAILVVSSPILIGVLIAGLPFLLPLMVAIMAMFFSVISGIGFVCASSKGGRAFLKDLLEPVTEPLFHSRSGQSLLYEIGPRPTPVHIAKLLLPSGIWSTLAVSLAIDFIGSASYLLPLVGEAFDLLWAPLQTVLIIALYETEDWGYPSLKYVSFFEEALPFTDIIPTATIGWSLLYLAPLVLGKAGAVTVGQAIMARTNAETRTALTAEPTNVQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1W6</accession>
    <name>A0AAD2G1W6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS18263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1W6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="248"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1959844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="593" mass="65280" checksum="662828963C5F4234" modified="2024-05-29" version="1">MEDSESLLPPLQHAHTYVAGEDGSRLKKVARGFGLTNTEARIPQPNVRVLPLALKLLWSDDTLERARMHSVGTLADNERLDDYGNVHRTMTVRRRRRRRGEGLVPLGHVKPDYGGDLSNLFEHPSKIDEGDEEDEDDDDDDDEESVDETIDVEVGGSITAAVFGIIKGTIGGAVLFLPRGFQMAGYALAIPIMILSTASYLYSANRLLECWRVEKAKAAMIDEIRALLLEGSPKMYGSTKAGEELKQQPSEGGKLLSYPELARRAFGSGAFCVELGIATMQFGVCLTYLIFVPQNLYEATHQLFGWEMSKTVFLVCMVLMEVPLAWIRDIRRLAFFNFIATLLVAYGLFSCVVLAFMEIAKDPELTYLDRLADLPPTNPDTWILFIGTAFFAFEGCITLIVPLQGAVSREEDKQRFPKVNQTVTSSIVAFYIFFALTCWAAFGSNIKTALTASLPPGPYATSVQLAYSLAILFTFPLQAFPAMEVVFHYTAHGAIKTDPSVRKKLSIQATLIVCCLGVVAYLAIDYLGNVVSLLGSLVGIPIALVFPPIMHNILVRDLSTFTKVLNYSVATLGVVIIGVTTYITILQWDKGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2Z9</accession>
    <name>A0AAD2G2Z9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS18855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2Z9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF10">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1960710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="13183" checksum="C34C4B1F38D433A4" modified="2024-05-29" version="1">MAADPNTDPVDSALDKLKPIMSQLSFGSVLGYCSGMALKKLGKAAAFVVGVGFIGVQSAVRAGYVKVNWTKIKDDAISPLDTTGDGKVDMDDVKGWWKKLRVILTNELPGAGGFSLGFITGVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G330</accession>
    <name>A0AAD2G330_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G330"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="845" mass="94387" checksum="8E267C39DBF1749E" modified="2024-05-29" version="1">MATSYEREPEWQEAPANDASNFRSVTPAMNNIRRNASPAKGFSDDGMPEEKKGGPSSSGLIRLALRKPMGIVFEPMYDPNSPSVQRGVRICDLPRTGAAALSRKLEVGDELLSINDKTMSRLTFDEIMDFIIEADPEQVNLLFRRPRKEVLNARNGNKPPSGGPGVKWVDDDEPKPEKKKKERKDKKSSRRSRGKEDDETLQTEDDISYRRSRRARRRHNPYESESFLDILIDTICANPDSVCRDRRKMGDDETYYSEDDETYASRDDSTYVTYESEPPARNSRKSRKKNSRRDDYSSQGADEDTQEEKQRSKPTRGREREPEVRRPSPMREPKRDMTPIKEKAYEDDGTLETVDSKERERAMQMEAPEPEPVPVPPLGLVPNPEPTRGNLPPTQIDEDEQTNPAAPIRAVEFDEDADVGADVSVMESLGGPSLLIEKQRQAQILASKPEVTPPVPRDIADNFGLDYPLDFGFSREQTIQNDPLRFYSYVVKALLQEHEPEKVRLLDKLLAKYKGREDHLVQKLSVRYNTEEPADEQAAAPESEEQGFGEPANFDEAVIKAKGSAHSMENIETARERMNSFSPTNEWPEKETKEQEPLDEPPQMKEEQPEEGGSHDYSDEDIDGTSPAVIAQVSELLNYVYGKTSVPGQIDRVSTIMRAYEGREAVLLELLETKALIKANREKENAGNLPAFLRNSMNAQREVDEDAIAGGNMPAVTPMAMEGRPAINDDMSSMSGVAPPAPPDMQKGVLNALSSHSETQKPKPTRAPESSAYTGPSAASPPADTKQQVKTRSPTASAAPPMDSKKKKKGFLGGLFKKGKKDSKTRASSNGRNLRTPVKHTEASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3I0</accession>
    <name>A0AAD2G3I0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF3641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS19197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3I0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024521">
        <property type="entry name" value="ArsS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026351">
        <property type="entry name" value="rSAM_ArsS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04167">
        <property type="entry name" value="rSAM_SeCys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43728:SF1">
        <property type="entry name" value="FE-S OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43728">
        <property type="entry name" value="SLR0304 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12345">
        <property type="entry name" value="DUF3641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="146"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal" evidence="6">
        <location>
            <begin position="305"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1961439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49675" checksum="3577608CDCC9D0C9" modified="2024-05-29" version="1">MKFGDIQGQSLFWLALLAECATGFVVTKLNTVSSTAFTATSLPDYEVDKIKLEPKKKKWRREDLFGSSIVDQTLQELEEDDDFQATKEKLKTIGQEGMSKEERTQRRRALDNLGIEPFAKFLRKEMGTVDGKPFVLKRQTPTILQINIGLYCNQACGHCHVESSPLRTEEMMTADTAAQCLALLKNTQSITTLDITGGAPELNENFRYLVKMARSIRPDLEIIDRCNLTVLQEPGQEDLVEFLKENKVHIIASLPCYSEENVDQQRGNGVFERSIAALLALNDAGYSSQSDLRLDLVYNPLGAFLPPPQEKLEVQYKQQLADNFGILFDSLFTITNMPIKRFADFLHRRDELQGYMDLLVRNFNKDTVENLMCLETISVGWDGKIYDCDFNQQLGYAIGVDSIHRGGKTVFDLESLDELIESRIRTDNHCFGCTAGMGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G509</accession>
    <name>A0AAD2G509_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="7">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS19963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1963005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G509"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1963005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="409" mass="46472" checksum="A234D364F56FB46D" modified="2024-05-29" version="1">MMPSTTTRALRQGLVRPLPSLSSQAQAHAPRRAVSFRRNDDSSKRSVSTLIVLRHGQSQWNGPQARFTGWCDIPLTVRGRVEAVAAGQLMRSRGFEAKRVCVAFASELQRSHETCELALASMAGHEQETWNPYRIRKDWRLNERHYGAVQGFYKNDPDLKEDYGEETIRHWRRSMHGKPPKMGKMHKHYMPPPAPQTESLYDCQTRVVECWEERIAPALFEEQNLPYPPDQRTVLLVAHANTIRSLMAYFDNVPEDQVQNMYIPNSVPILYRFNTETRQPISVKLESNHGGSHARWMLGPENHSAIRTALTQGGTLTRAIFDALGAGRDLTITGRDIEVGVRELMRDDAPMDCVVMGVAKEICRNIKPDEKIHYSEFERLTQETLQKLTLKNLGPSDIVAKDSASHGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5T0</accession>
    <name>A0AAD2G5T0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1963932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5T0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031052">
        <property type="entry name" value="FHY3/FAR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669:SF251">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="783"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1963932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="897" mass="102053" checksum="52A729F692173674" modified="2024-05-29" version="1">MSLLAEPSSQSYLEHQLQNAKARELQWKAVLPFKGLIDHEDETVNLFDYVGKEQQWRRDHAIRFDPLQFPPTPIGRKELMNHLRVIACYHGSKFHADPKTGLLRCYRCRISATTNKDDPNDYDPCGIAADIRRKGLHNDRRNNRDNGQKRKRATTTAKDTTGNLLCRLKLTFGIHKDNALPGGGYIFLKCTGNNMHQHHIQPQNGELSIPANLLTKEQCRIIYAQQHAFVGGTQARKVLLELRHGFISASTHRRVIETAPDAITAKPGTGRSSASELLNWLRREASKPGDSKMSYCVLSYEIRPETLNLVSDFIRKPVGRPSKTNPPMAPIEVAKNLTYTDHSPIVGLSKTSKAKEACGQLFTIGNVNSTTEEGETDGLDSINQMSKEETKIPLKSVAPMEQLTTQSEIRLHLNSKCPWVNSNRSRVLIGASWMVEEDKRQFLRYPEVLFMDATHKTNNEGRPLLLICGRDSDGKAFVILRVFMPNETSAFYNWVFQEALPSMLGKEHLERVNLVLTDGDSNEFSALENSMLKLLPNALRGRCGHHLIKKTLQKKSIAPSYFKNRVLGEAILQEIEGWVRSWADGSSCLTEEEFMFSKNLLLDELRNNEQLQEVMGLESVGKLMDWVDTDVLPHEKNFAHYMKRDHRCLGEYVTNATEGLNYAAKHSSMSAKPDQKMVTSAGAMHSHDDMKNRERKKKKLRQFEDTPLFLERGNKRHNSDCFKELVPIGRSIMMDQVEQSAGNYVVAQISPDSFCVILDQSHVSRPHGCPAWFKGRPRFRSVNIVEVDKEDSNRVVLKCSCRHKQHYGLPCRHLLSIEHQYDLSDIACRWRNDYDLYAYSNGKEKTMTRLFAELSKVEHQGILVKSEFFGIRLMCIPHFIPVNKSGTGRLVDLGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6H8</accession>
    <name>A0AAD2G6H8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6H8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="299" mass="33887" checksum="29C4F0279AF60252" modified="2024-05-29" version="1">MAYNYQGQQGGNTTHASIILNHILDTLADVLKNAEETIRFLPLSDSAYKKSKQWIRIEADLRRLIPDYRSLSKYLDMSFGNMSYASTSNKPGEKKLRTRMRVGFEVKVAAGTIRQYLHGQLRPQGYSAGCYKSVLQFGDIEKVGALCFNPKEINIRAMEKELIWHFDWKIVIGLRYEWVNIPYNGRNFPWCAVTHYISDWKAAQNRTISVKAVGLVKDENLTMILKHKDFVELTQAKYCPVEIPGMLKQATTKAFGPHTCLSMFLSIEAQPVHDKKVAAAEVNSDSDSNGKTSLTSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6Y8</accession>
    <name>A0AAD2G6Y8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6Y8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="88"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1965163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="435" mass="48183" checksum="1D99F8720F487059" modified="2024-05-29" version="1">MAKQPNSQRQDLLQVIASNPFQTHPRQAKFWHGRVFSKEQDEENRMLLLLPPTMTWESPDKPRDDHHNTNIEDDPKSWLTASEYQDEDRLMQLKIQKLAELLRQSKKTVVYSGAGISVAAGIGQAARGSSQNGTKKHPIFGITKANKMSAKPTPTHYALGALASNDLIHGWIQQNHDGLPQKAGFPQDKINEIHGSWYDPSNPVVKYSGSLRHSEYKWMVKEAESADLVLVLGTSLSGLNADQVPIKAAHRSLQGKSLGMVIINLQQTPQDGKASLRIFGSTDNVFRQLFHHMKLAPVPKSISKQYKFPKDKKFLIPYDAQGDLYLVSNGSGGGGNNDGDSYKMVWDLNVNAKVQIVNHNVEGAGQPSHQPVLAQNPELIGRVIAWDNDSMSIQISISGAVFRLGYWWIETAMQGRALTLPLVNVSPKFGGDGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G760</accession>
    <name>A0AAD2G760_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G760"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042168453" description="Subtilisin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="40065" checksum="21395984D3B801EE" modified="2024-05-29" version="1">MQNRILLIALLALSCVSTTTGNQRKIVRLAKCFMSDGDGGTRFLAGHIASNDTDSMMTADTLTCLGNVSACFDETTVETVKTCIQDNNDTDSRFLAGHVMPDDNGAGFGMGGFRPQMGRDTRAGIAMGCLQDSSKDCIKQEVRTFIQDKLPACVRTTTTALGECYKTNAETCASTCSEADIPDSNPFAGVASTNVKACQGFQNQIMDPSCEIVDCCPQCDTEFSDLMTCVGQELLMLQPEPCELSCPSESTRRRKLSTTTSKQQQYAMRNLAGHLPTEPDASTVVDECAVYLDTEEETLSADAVAAKLLDGEFIGCVADVAILVAEEQTAFAMAQDDMGNGDGNENTTDGSSGNRVLTSSVNGLVAIVVVLGLVGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8E8</accession>
    <name>A0AAD2G8E8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002262">
        <property type="protein sequence ID" value="CAJ1966194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8E8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="347"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="824" mass="93967" checksum="DE5831F67E65DE54" modified="2024-05-29" version="1">MKLHATFSYFVTRKPTVEQLNDVHPNHVYMLTPEEFDPHKSSDAQTEDHLVNYDGEVADARNRSKLFISDIEDDPTMTVCAMSNMRMEEQTLVDEFVLEERDADEGLLGQPFNVDLASISSIFCERTLSHRLSTRREVLKIHRHLDTYDPNPAYEVEFDDGTVRDYGATTIAENLLTQVDDDGYSNTMFKAIVDYKRDPKVAVSEEKCYVMSKNGQRRTRKTTKGWKLMLLWNDGTQSWIDLSVLKESNPVDVAEFAKAHHIDEEPAFRWWVPHTLRKRDMIISAVKARVRKTTHKYGIEIPTSVEHAKRLDAQNGNNLWMKALSKEMSNIGVAVEVLAYGVLALPGYSKVTGHLYAGVVSRESVRIACTYAALNNLDVFAADIRNAYLQAPSSRRDYIICGPEFRLENVGKVALIHRALYGGKTAGRDFRNHLRACMHHLHFLSCPADPNVWMRPAMKDDGSEYWEYVLLYTDDALCVSMNPERVLRKELGKYFELKEESIGPPKIYLGSNVRKVELDTGVQCWAFGSSQYVQAAVKNVERYLNDRSKAGDERFKLKPKAMTPMQTSFRPELDVSPELEPSDASYYQSLIEVLRWIVELGKVDICLECSLISSQLAMPKVEHLHQVLSIFSYLKSHHNAELDLSYNLKEELPPNQPEPKGIGFVTTAKVDADHASDTTTRRSRAGFFVSVNGALVYWMAKKQTAVESSSFGSEFCAMKLCCEYLRGLRYKLRMMGIPVLGPSFIYGDNKSVLANTSIPDSQLKKKSQSIAYHFIREGAAKDKWRTSYVNTHENDADLLTKKLPYGQKRRKFVNRLIHHVYEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8F8</accession>
    <name>A0AAD2G8F8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002230">
        <property type="protein sequence ID" value="CAJ1965854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8F8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF101">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042028819" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="363" mass="41036" checksum="82754293EDFC653D" modified="2024-05-29" version="1">MPNIGPLLNFFLSLQICSAMTRMKTRIVSYNVLSSHLARVEQYPTLNPKHLKASARLLVIFQRLDEEVAKKSIICLQEVSHDWAGSFHTYFANRGYHLVSGLYGKRFNGYMGCVIAWPVDTSDVLQVDISRLSDKRKGGWPREPKQGILARSFTRIVGKGRDVLEALGILGRRATDHWTVAENRFNILLSIQLQDKLSGKSYFVSTYHMPCAFYAPMVMTLHADLAAQHVQSLAGQCPYVLAGDWNIKPYDSTYNLLTTGMMDLGHPNWPTPKHGTEWAPSCHPMRSAYSESQHGEPDFTNYARTREEEPFIDTLDYIFCSEHWDVDGVLPLPKRENAHGPFPNLDVSEPSDHILIAADLSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8L3</accession>
    <name>A0AAD2G8L3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002259">
        <property type="protein sequence ID" value="CAJ1966181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8L3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33802:SF2">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33802">
        <property type="entry name" value="SI:CH211-161H7.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="396" mass="44402" checksum="EC46D6D9A880C9D2" modified="2024-05-29" version="1">MSPTSIDSADSVPRTDPRQQSQSPSMFSPVGDPTRYSVSVDDDDSNGNGHEEEDFIHFPTSPVQHVLADQDLHDSSWQHFDDDIAEPPRLRLESDMNAPLLLQNGNRRHPTPLNGLNYLNFITYCANCFVSFNVGVRGLGSQLPKSVDVFLEVQTLITPARWAYILWAPILVFEAIFAIAQLLPYYRARPIIQQGTGYFFFWTCLVQTVWTLAFAFEKFIVSFVAVLCALISMACLLASQHYYRVRGKKSLVEYWLFRFPFYLHCGWLILSSVVQFSILFRYLTSNIGVQLAADVVALGAMLPPATFFLTGQPSGPDFVIPLVIIWSYIGIALPLHNPSDTLLATYDHSDIVAVRDSAYFFACTVGLMLIPRVVIWAFQEFCTINVVELGDASTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G915</accession>
    <name>A0AAD2G915_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G915"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="700" mass="77312" checksum="2B64B0DF425416E1" modified="2024-05-29" version="1">MESQQVDGGSEPKRLKTDESSIPKESTGNGEAVPVSEAAKRQIMIETELNGMIQEMMASEDFEEEDEMEPESYAAIMKAAKEICYTRKIYDVSADKIVFFPSITKTIVNMDLFEKAEEYYYDEGDEFPMEYSMGLRNVAFEKLEAEGDDDEEEMDDDMMERLSMAVQLTEDDKDELQEAIAAAEAADEEEADQQDTDEKEDFVMDPVTAAADQKEEDQDTDKKEDYITNPISDASDQEETDQGVGEKEDSATEPVNEVTDQEDVDQETDEKGVSAADPIGPQVESSSASPNENTASDTVSKGEAVPVSEAAKRQNMIDTELNGMIKEMMDSEDFEEEDEMEPESYEAIMKAAKEICYTRKIYDVSADKIVFFPSITKTIVNMDLFEKAEEYYYDEGDEFPMEYSMGLRNVAFEKLEAEGDGDDDEEEMDDDMMERLSMAVQLTEDDKDELQEAIAAAEAADREEAESAMDPVNEVTDREEDDQNTDDKKAAAIDPVTEAPGQEGADQEIDDKKQDPVVDSVTKAADQEEADQQDTDEKEDSAVDPVTEAADQAKADQQDTEEKKDSAMDSVTKAKDQEEADQQETDEKEDSAVDPISPQQLEASFESSLASSSDVGGDEPTLTHDERSAEVVTIGKSNLAPDESGTPETVPSEEPATKTKAGIFTKGLETAKGLFNEHTEMAAVACLAIFAAAAISATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9P8</accession>
    <name>A0AAD2G9P8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1457" mass="161857" checksum="FE83CCBFED608B91" modified="2024-05-29" version="1">MARKSSQDQSSAGIIVETLMKEARERVACDFLEACEGDEAKRAVVLELCKKVLSNEQYSKIVSAKRSEEDDSEIDEQDDNGNDESDGSGERDEGSSDDSSIPTMKDIKGKPYQDGISAETGELPFEEFEDLFEPDGNQQENQKEQMCRRKPSLIPNKDAIRLFGAEAAKKLVNWHHHVKHSGQLYSEEWLEGRIRDQNLGTIAKPMLLICLQHIKISRAPTAVLGKICHDLELQSLIKKALEVWGVADRFPRLWARKPADQYARTGDIKMCRQCEIFVARAYVCVTTLKHAAVSDDLGNKLLSCLVDMEKNLPPDLAKKRARRMSKDSPRRNGTPSSPASKAMAKSIASNTSKNTSMTPIGSLNDEKIIQQVCQHTGKVLGEFNSARDIVNRLGDSMNVDYICKVLKGKQKTACNYIWRYKKVSTSTNTISKARGKPKTKERPEDGRNGGREDEEMDSQVASLNKRLGKSISPTRKEKAGSLTDIAKTKSVTRNTSNEDTSDDTDDECNIEQLSLETGEVLGEFSNVLEIEDRIGHLLNVTSPRSSIFTVLRGVQKSACGFGWRYKKKSTTARNISSQTVSSKETKGGNRADSNKGDTQAASPNMGLDSSMSPKMKEKVASSTDNAKNNLAATNTSNADACDDTDDEGIIEQVSLETGEVLGEFSNVLEVEDRIGHLLNTTNPRKRIKMVLRGVQKSAAGFSWRYKKKLTSAGNKSNQTNKSKETKGDNLAEGSEGEKGYIRAVSPYKRLDKTEPTQQPMKKSSSTLKEVTKKTSPLSKPSNYSPYDEANDDRIIEQVLPDTGEVVGEFSSIRDIENSIGHSLTNKNPKKYIRRVLKGGQISFNGFIWRYKGDQNVHTAEAHRKRKAIFGVEGLPSSKGAKLNSRSRSPGSQDNYPSISALQHLPSTASSRALNVRAIASMVEIKESPYMKEASAEVGEEMFDHFKDLLLPRGSDGRHLEASQQAKDLFGETAARQMVTASTLIAKSGMVYGSSWKDGSIQGKKCGLISKPMLLLCLQEQRLASSSPNGLQIIISDLGVVTILEEALKFWKLGKNFPLLVGMKSLSAIQSRTKGLLGCMIFVARSYRCMIAIKRTKVSDSTLKKVRKCLSIVHDSLEQQAARKKRVQEATQETCVGKSMEPIVQKQKVGSNPFAHTNGVNLSRVDESMTSHEPFSPGIIMHNLFLKPAKVPGEAPKEKPRPATQKDTKLSTPPELARAGTTRANDGKRMEQDRGKKQTTAQPEHNFLQTNQRTQAQPTNRLLQPIQQTPNRPAEDIHTLANQGAQNPVPINSQESNKDRFPVTPSDPTTRAPNPKLPTNAPNPLQSINNVPLPPLYSVLEGPWYPPDQASLLNDAETELAWLTTECSFALRLPPKTIIWPFIWEYSSPLLKKELRQSRETKLEKLVRLHDGFVRDRFKVLKGEIQKELNMGKRRPLMEKIIPLLRHRSRLANRLKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9T6</accession>
    <name>A0AAD2G9T6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9T6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="440" mass="48627" checksum="A86B8580BDD5C25E" modified="2024-05-29" version="1">MASPRILCSRGTLRLRHQFTRRYRLFSSSSSNSAASDGLGFSVASLGLEKSFVQPVVASIRQLPEIEALYQDKKFASTSGVENLNRAVDVFASFSKGGREHLAVCALLAESKQRMAQHQDVLEILIEMEELAQQDGSIPNSFEDLTLAKAKTCWTKGDFDGSAELCETIISTYNDLDETFPTTNLHMASAMSGKALSQLASMKTIDDAYSVRDYFRIAVKFLERHPPSSNSLPQAVAYGNCGSAEAAYALFLEETNDVSVPMDAALRCWFQGMQHLKGTVPTHLEMSSNTLEANLQTNLAWGVLNFEMDRSDRLEKASDYAKQALSAHDGEGGANIWGMRRVLSTVADCYHQAGSAVTAEGLFQTAIDKKKVFLHPSVLLELQDSYLSYAKLCENWEKRGGDAKQLKDRAMEIENQLPDGWKGKSGVYSSLWFWTPGDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAB0</accession>
    <name>A0AAD2GAB0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002316">
        <property type="protein sequence ID" value="CAJ1967248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="638" mass="70274" checksum="F575F1341C7C5692" modified="2024-05-29" version="1">MEHGNCPYTATNSKPGEKKLRTRIRVGFLAEASVEAVQDYLHTGLRQLGRGAGCHPSPLQYGEIVKIGSCSFIPAEVNFSAYAKELMRLFDFEVPICIKMDWVSIPYTGQAKYDKRSPAVTSPHCFTRRIHAKRVDRTLRSILHPATAKPDFPFAAPATYISDWKSAQQGLLSVKAYGRVKDAILTLISKLRDYYILTEVLYPGINFTGMFKFATTRLYGSCTLFKLLLSIKATPAQADQASTAAKDRPPTTANDNSSEEEDDESQEGAGSLSGPFTKVTKKKVKKKKKSLISDNLENHFLKDLSPAQRKLAEATDRKLKNDIDRHKAGPLFLMILPGEMEGSYIFVCRKKYGQLARNVLRGIVPFLIHHLCELTNTQADRVLGKWIPKSEIQATRRKCLVWCTNTLRAIEASDQSTKVEEALEFLDDVIEDTTDVYQGQLSIDMDMANAKDIDDGQTVTGMLDEMHKHEQQLEDAFVEIEACDNALAAKDQALAQQKAATAALQAQLEVSPDRSEFTMPPKKRKSKDTSTTKRSVDRSKAGLKPPTKSTCTSTSVHFQQPKQRSWNMSQVQVDTTQMGGDTTTAVSQDESLSSLTAASPRGVHPFFLPSPSGKSGTSGSAKLPSLAGRGAPRSAAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBL3</accession>
    <name>A0AAD2GBL3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002339">
        <property type="protein sequence ID" value="CAJ1967698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBL3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="817" mass="91378" checksum="2945F4D0C277B2F5" modified="2024-05-29" version="1">MVTGKKTRILEREKAPIVTMVHQEEEQPKLVGRPKGSTKKATKDVVKKKDLAKIMLTERYANAKAAASPKRLTEGVYGKIHNEVMEELGLGRTGFSIPKTTIQSRVRGKTTTTKRGPTSPVAAFEPYILKITLYRQQAGQPLTQPETIALANSLVVGSKLEDKLKDFHSKHKAQPTELLGKRWFKGFMNRNRDILNTGRGSKQDRARKDWTTYENVQQMYGLVYEQMLQAGIAVRLPESEHYWVDNVGQIVDSEDKAAGHKCTIKLIHPEYLLFGDEVGTDTAQDQDGHIGGETYIKSADGQKVELLSTKATGRFTVMGLTAASGDPVMCIVIIAGKELACEDYIGFDHQSDVMYDGTKTLEENYGPGKVLPGLPVCVFRGKEVPGMVAVSPKGSMTSEILKKALETLDELGVYPRTRQGPTPMFLFDGHDSRLQVPFLEYINSEDEFQNPLWIGCIGLPNGTAKWQVGDSVQQNGSFKMAMTREKKRLVYHKIRMMHPSIDIKRSDIIPLICKAWAVSFARKVQNLHAIIARGWYYLDMRLLKDTDILNTRVTHVNTSEGTTAESEHPGTPVTPRTPQLVDCQVEESAFTDNIGPLALHMNVGNSEIMIDMIVHMRKNAGVQARLKERKKKIAADAAAHETFMKDIKLTAGGLFKSGEVHLSNRVLAVRRERDAKKLESVLDPIRRAVDGFHLRMQKYTELELKGITNPKKMNVLQIGTWLSVRKTKADKIPKGKDLQIALMKEWAGRPLLNLRQHLLDLGKQEHNIDTVFAERARIAAEVEAFEEEESDGDGLLVHRLDMTAVSNGGKKTMEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCW4</accession>
    <name>A0AAD2GCW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS24116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002458">
        <property type="protein sequence ID" value="CAJ1970093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCW4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1970093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="181" mass="20481" checksum="893A7304412C9315" modified="2024-05-29" version="1">MGVYRSGRCKCGNVSIAIDMKPFLAYNCHCSHCRGFASKYQSKPARYSGGGAVWKWNVTIQGSENIDYERSTSLGGLFAMSRGRCSQCHQTIWESGERVIFPFAMVMAEPLLGLKPDTEIFYNSGYKDWKASPNNMVVHSDIGSLMYEIYLIVFVAIPMIPWSLFKRMMRGDPFANDVKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDG8</accession>
    <name>A0AAD2GDG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="501" mass="56502" checksum="ED454DAA3A954227" modified="2024-05-29" version="1">MLPRRLSKTVARSLLLRQSPRHAPPPQLNLARRAFSDKLMGFSPMAPSAPSSPQQQGESRIPTAKDVTTAGGIWAPTSAKRDKLNELRTELKDGMESLDDAATESQLQDLYLVDGLQLISKTIDSTTDITTPVIAECSEWLVEQQAKMPEGMDKDKWEAHLAIVKEHIDTMKNSHISSTSNCLKDVRDYLDPTSIEEQDELEKHTSEPLLQVQDEPFSQAVLLLRFQLMEAAMEHFLASWDACTTVSDGDVDRAATQGISVEPQARTLPTAKVYKYLFAHLSGSCSERVDAAWDFIDKDDDGLLDESEITLVAELCLAPVQLALPRLFELALNEEPATEADLAAAALEASDGDAKPSPPQKGWRQRRREANMKKQLIKMFDKAVQKTFEDEVEMPHRLRCIYAWAEKAHQDNKLESIMVESGWSDRKRYVELSPKISLPEFREVQREHFTHLDRIGTEILKSYREDLWVLQGKGRERKELMRDSALFMAVVSLADYLILAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GEP1</accession>
    <name>A0AAD2GEP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS24490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002524">
        <property type="protein sequence ID" value="CAJ1970474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GEP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1970474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="238" mass="27365" checksum="DFB96390E5EC0A4A" modified="2024-05-29" version="1">MPKAPLKFPAKLYRILNTPEFNDIICWQPHGRSWRVLQQSRFEKEVLPVFFRHGRYASFIRQVNGWGFRRIQSGPDFSSYYHESFVRDSPESCRRMRRPTIQELADRKNADFDSTPNFCLPPAVQQPSKDEKNIEKAAAAALPPSSEAPPRNYMSNLVSRLLLCTSEEKGTLLSSELEALEEQRTSILQSLELLNRNDRRPAPLSYDASSFALQMRADELMKLSLRSQLLTCRAADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGU0</accession>
    <name>A0AAD2JGU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001740">
        <property type="protein sequence ID" value="CAJ1948092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGU0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="80"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="19531" checksum="5B36F9860984BF48" modified="2024-05-29" version="1">MVSRTGSNEPMHSIYPMTSRWEFTLQNGDKVSGEVYCTDPVAGLVVLIERGDIKIITAGTIQESKLLQKATTESLQSGNMMHSKKALDEREKRGIRLAQESLRHLNPKASPRGQAVFDRLLKACNEVVWKAESVIVLNQIQVDPPYAQENCKLLQPGSAQAGGSLERVQKIVSSTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGW6</accession>
    <name>A0AAD2JGW6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001737">
        <property type="protein sequence ID" value="CAJ1948022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1424"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1701" mass="187261" checksum="00676BFC6DEB8670" modified="2024-05-29" version="1">MPLPVAVGGRAVSAETLPRANCREEDSDDGIPLMPVELYQTIGWGVCPQNEWLVRVTTGYYDLMDFNKGGRDCTMCELRIQVSLLAKPLSKQYRETVHHLKLVDGASDDYPQFQPQIAVSQDRRNLAVLLFHPHQQSSAVVIFQLRKPRSDLTPKTSTTNSTTPMPMPAYCNKISYKRQAPAVATNPNIVSVWGISAICSIPNVLPSVFLAACNDGSLIWLDARSSTTIATGTLAISSKQLPISSLSVSAKRLERGCLLAVSSATGHCILAQWKLESGTAVQLTKLERNSTGDLMVRSQLSAKQVEHHQDCQDDQKQNHDLAESYNPEDTSTQGASATKRNATTHHTSSDNSEKSKEENHRALSSRSSTNKEQHDGIQNALKGLKSNRFWSGIAPKNLSTLASNSTNSKANNTKNCHSTTNAQLINWKSAFYQKDNSPEQNTKEGVPPEHEKETTEREARRQKNHMNQFVLQELRKRTTAASWVKHSTGRRAGPRTSLQRRRRRSDVAGQQEDPLRSIMNVGLLSVLEQQVVAARFGTIPTVICVVYQAARKHPQVAQMFSISEIGTLQPIVSLLLTSEQVEEATSLQSTNAIVSDEDWDVKNSINTKFGLDLHVESDTFAISTAVGDQWIGCVWNWRTNAIGLVVQNEANLSLWSRLYFGKEKQTGLKLCYLETCIQDLRIQTHKHLITAGVLSPPNSRAIQLESCPLFLAADFVAFPYLSHEINNGTQQLAWKSSTLPLSYINAYGAPKFAAVGRQNSATIAIASSSGVCLLDNKYRWKQFGTPIEESSFSIVSMEWWEGNGTKKSEENEDLLVTIIELRSGKQYLSCWSPKRLGTSHQLLVSASPDTGTETKWGIPLAEDVKVSSLMLLAEPSSKSDGAQQARKAVVFVASTDPEASELVYSSFQLQLTTLVKGRSEKRTNSVLTSKTISGILKDGTRSIGPISSIFLAGASFRFDLQDRCTSTLASSLVATVGVVRSPGGLEVISYDARNTACQSTLVHANELSKISLVDVVHGVNRLVDTFVWAIELLNGEIFCWSVPSLLGAAIDETLDFYSVPIGDDTLNPSVLHPPVRVCKRDRRNKLMRYAMGNLSHAGSSSDWMQRSAVGCQSDIFVGPIPHSSYGCGLSAGQRCRKYRRACLYGTSDDSYAVDISVSESYGPSNFMITPPAFVPSLFSMHVETAYRRIRMAQPGDSNMCQELKEDRARILSIERHIHNRMTTIQNKDAVTMTLRLFVLRTVEMVADLHKRHGKAPTDASQAFLLVATTVLSEVIESVRRFATDLQFASLFLEVGRQMEPSCLPHLFPPPPSERSASASQSSLQAAMSVADLFGICLQNGSLMASASALPLLGSRVQSRVSCLLLMTRAITSFIANTSSNDTRFDSTEEERSVMGDIFRFGIKLEDAARLEPDIEEDKGDEEAGDQRAFHPIPNEKPDDDSKSILSENTSNSSASDFSDDSSSMTDTRQLLCSTERQNRVMNVFSMFDHKSREEHEIRKSALSFIGVTMESEADFISIDQGGIRNGEESHKDMDTNIMCELVGNSLVELILSPQTDCPWKAMASLARILAQDDDDDGVAIFSKVADSLGSTEIDAMIPDLHPDLRAGDVMDRLTEFLVTETGHCGTEITVEDANLIVNLVLRLLQFLEGGHLPIEERSILPGLVVVGLVASSVAGREQQLLSTLREDCFVSECYKVIAYDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHF1</accession>
    <name>A0AAD2JHF1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001763">
        <property type="protein sequence ID" value="CAJ1950347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="269" mass="29223" checksum="D73E4D8A58EBB82D" modified="2024-05-29" version="1">MATAWYRPGVVPKIVKSWKVQVQVGIELDVEIWSTTCIVTNFKEARCPTLLNPANPSLSGVSKFPYFPVGGPEPDVLPMKDSHPIMGFVSQWGGMDVGKGMMFAANTVDGMIHLAGGKELAANLKLQLGGKERIVEGQAVWTNGVGDYKHLIHTVPPFFDNSDDDHSENRLLQNCYQTSLSLATDRLPSETDIRIASPLLGAGCRGFPLEEAVFHCAEALSDLNMTISTAVDGGTNAIKGLTLAFGVPSQDIREEMIKAFESRINFTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHS4</accession>
    <name>A0AAD2JHS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS12952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHS4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041993850" description="N-acetyltransferase domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="98"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1951194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="331" mass="37791" checksum="C83A9B8622F43BCD" modified="2024-05-29" version="1">MRSSILSAAALIFILGAGVDSLVQPPTSQRHQRLLNVDSVKRHSFPRQHQSIHERYSSFSQSPDWYTDSPTRHAPVSAYQEQKRIIQNTKTPSPNEVLWMRHATIDDIPALQQCNRALLPENYPDGFYEDYLRQFPDLTVIIESFSVEESTEGHGPNSSSSSVSSAQPVPIAYAMGCIREIKAATKQQQQWKYLNKRANSAVRYDNLGYRPLVRSGHTISLAVMPTHRKLGLATKLLDYLHDAMKHRYGAVVCDLSVRMSNERAIRLYENHGYNVSERLYNYYKNGKLEDGLKMQKVLSDYSSSSPESQITLPQQMLLQRPQKNFDSVSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ17</accession>
    <name>A0AAD2JJ17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L13a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000009">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22716" checksum="F2A6F815E56A279B" modified="2024-05-29" version="1">MVLEKTKVIDGRDHLLGRLASIVAKELLAGQKIVIVRCDEMTVSGSLVRNRVKYAQFRKKRMNTNPTRGPFHFKSPAMMVWRTIRGMVHQKTARGQEALSRLSTFDGIPQPYDKQTRVVVPAAIRAIRIKPGRHYTVLGTLADSIGWKHKDLLERLESKRKAESKEHYEQKKAKAALRRKAEEACAGELTKVNEVLAAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJC1</accession>
    <name>A0AAD2JJC1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001876">
        <property type="protein sequence ID" value="CAJ1955043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="844"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1132"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1200"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1219"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1955043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1857" mass="209446" checksum="4078FEF984D46370" modified="2024-05-29" version="1">MLNVSAKMNKALIEIGYMDKEAAAQHLEAEELTHEHICDKAEDAYRTLFDKQQWPAARPTIRDSKTPYAKMAKTFTPDDVQNHAYALIHQQTGSKGKAKPDDICLNCGEKGHWARDCKSDKKPKRPFNNNKKSKHQKDKHGSSWKTTPPAPGAPETKKVRGKDFNWCAHCGRWSTTHGTDGHTNDATKRDLKGSGPQANHLRFAGAWYTPFRNDQPSLLSLRVVWTILQHLLSYLPQLVVAFFLARSIGVTTPNVSAFIADQVSTASSFLADQVSFMMSQATAASAYLLTAASTVIAAFEGSPTNRLAPLLWFTLLILVSLPTKVQHRLIGSPPQEFRPFRMTKAKYKRYIRHCRRQRRPTSFSHRRHTRHYGLATRRRLDPRSQDIFDLVQHIIQFSESLTFRRSRREGDNWRSNRRHQRNHNDQSNWQRTNDGWRNMNDNEPSTPHATTSRETPRDDHQRRRPGDPNWTFYQGPRQRSEDDAFRFDPPRPRSCRHDSSRHCSDRHDPSSTPSDDIFRHFNTFPRTDRMRRRRMTRRRQPSMPRIYRPTVGVGLPMAHVAVLSSPAAKAFFKNADIPQRFSKVINCFRAAMNPDELRSDMSGDEKTTRYPIIWDSGATTSISPYKDDFVGKLEPAPLGLKLRGIASGLEIKGIGHVAWSVVDTTGMLRTIKVPALYVPSATARLLSTSSLLQTYTDESISMNADHLQLSGSDKTNSVHVDHDPSTNLPTSLAYSHGTAPNRFDAFASIITSTLESNHNLSPAEKELLRWHHRLGHLNFSQIQFLLRTGVLAHSESARRLQAAASRITTYPLCPACQFGKQRRRPSPGKTSRVVRDREGALKKENLFPGQKVSVDHFECTTRGRLLHTFGKEDPKTQYTGGCIFVDHATGYVFVEHQVHLNTQETLSAKISVEEQLRDFGVVVLEYLSDNGRPFTSQEYNDHLLKFSQIHSFAGVGAHHHNGIAERSIQTIMSIARTMMMHQAIHWPDVATTTLWPLAVDQAVFLYNHMPNQSSGLSPHDLLTKTRWKQSQLADVQVWGCPVYVLDKQMQDGKKLPRWKPRSTRQIYVGMSKRHASSVPLCLNPDTGAITTQFHIVFDPTFSTVATNVDDLPDFGSDAWSKLFGDSVYQYVLDDPEDPLHPPDPTDDPPPPLIERVREQTEVHNPPTPLDVVPPPTKPQADSSGAPIPPIQRETVIENPPAVPSVQPPPSQRENVTPTPTNPPKPSSPPQPTPPPAHKPPPTPTSKPAPLPSATRTSRRSNKAQPPKRFGYDGHGPAGYNAPLKSQSPETNNFYTYFSAYFNHSNIDLEHSHDCSFIPSSYKARATKDPDVFTYNEAVNGPNSEKWTAAAKKEIEELEGKLTWIEVPMSKAKTKIIPGTWVFRVKRNPSGEMTKFKARYCVRGDLEEMDVDENTFAPTVAWSTVRLFLVLCLILGWATVSVDFSNAFVQSKLDKPKWVHLPRGFVSPKGKGTCLQLNKSLYGTKAAPALWNKTAVEGFTKCGFKQSDFDPCLLYKKGMMVVLYVDDAGIGAKDPADIDKLIEELRELKFELKKEGDFNEFLGIKFDKRKDGSVELTQTGLIDKVLEAAGMTDCNPNRIPATGPLGKDPDGEPMNEEWNYRSIVGMLMYLSTNTRPDITFAVSQVARFSSDPKQSHATAVKTILRYLKRTRTKGMIIKPTGKLNLDLFVDADFCGLYNTEPHTDPNSVRSRTGFIVKLSNCPLVWRSQLQTSITCSTLEAEYNALSSALKTLIPLKRLLIEATDHVELDNGIRATIRASAFEDNQGAYFLATNQRITSRTRWYLNKWHWFWQHVTKDGVGPETVAIHELDTSLQDADYFTKAQSCEPFESNRFRVQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJQ0</accession>
    <name>A0AAD2JJQ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="527" mass="57717" checksum="3303D7C784F2B364" modified="2024-05-29" version="1">MGRSQVLYNRTKGRFRNKVRDHQSQQPQQPQQPHNDHHPRGYHQDQPRQGKEDNNSYESNHGKSADKKRARTRSTIGQNTTINESEMLLLADSAAPQYYVEDDTSTIFGGGKDKEKENKPKDPFATSASSLDIASLETTLLTCVSVMDRLKLPAHVAQSLQKEGSSMVVTTTISSCNSGFSSMMRTIDARGEADSEDMVRNARLRKQLVGESPTNMTIAPPANVASPELVENDSKEEDSFLASLSLADDDESADVIRPSYSGIQERGRTNLPAAPSLIYGATSSIIQTKYNNNKKKGNDDASYSIGPDKIKATEQGDIEVRMKKDDASRQSREFDVDRYAVIDEDDEDSLTTTDQRLPNSMRNVHVPKNRNRIAQPASGKLDPPTTTKDPPAGMIPPLRADPSDDSEMLENWLDDIVGVDAASSAAVHHPMDTDRDAVADRIGRAAPGNKNGPPVSSFPDFVGGTISNNASPMSQATAMPKEVTIPQRPVMVNALNHATAVPVDPRPTPPQEEVEDTLESWLDDVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK17</accession>
    <name>A0AAD2JK17_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042271203" evidence="1">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="201" mass="22341" checksum="F6C3084B7E83BDFC" modified="2024-05-29" version="1">MYRNETTLVLLLIIACSCLSNVSAWNNANNNKQGALNFFPLPFQTTALGGKHLVDAGKALKKASNCFQNIGDSYYAYPTILREAACSLTDAGNAWNQDHWEAVTYAMDDCASSFVMLSQLQRSVEMQKAYKGAAGELKVIAGLTEPMEATENLIQLSNYFKLVAKVETMEERHRQHVDTVSFGKYLKQASQSVQTLGREQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL64</accession>
    <name>A0AAD2JL64_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="227" mass="24907" checksum="19CEAF4098CCDE1C" modified="2024-05-29" version="1">MSVSAARNLVRMITPPSQVASALDWRKHTGGAILSLDIHKNSIGLAIAAHPSLQEHATLLSSIPLQNRGKVSEQDKDYLADVIKTNKVCGVVVSWPLQEGTAKMGHAAGRVFHTLEGLVNEEDSESSARIVSLLHLKPLCLWDSEHAENSEPEDIFGRSPAYCRTSSKQEHRASEEQYNQDEKIVATGVLEDFLHAFWPDVVSKQPTMMAVSSDDEQEDEGPKIAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLD0</accession>
    <name>A0AAD2JLD0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002083">
        <property type="protein sequence ID" value="CAJ1961135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="82" mass="9213" checksum="F3520C5C26D54898" modified="2024-05-29" version="1">MDKDEYHKRVAELAKTAKPTEICSLKPNHKNHTISECKANNNYKARMSNKKSNSFAVINFPGDKPDDDLTTSKETDSSNKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM24</accession>
    <name>A0AAD2JM24_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF26">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="666" mass="73832" checksum="1F8C0E14C4577915" modified="2024-05-29" version="1">MGSSWSSEDELPRNENGKRLRPISFEDDCDDDYEDSHDHERYERHERHAEASYRATAMAHRATTIREDEPPPVLRTRRAKRQRIESYNPAAATDDAATDDAHDAHDDDVSSSAANTSASYPTFSYSPSAFCRWTLRSLSDKLCVLLAQAFLSLAESSTARASSSSNININNNNGGGGGEANQYVNFPDEELFQSVSDMLDDFQSLEPDILTRGWRVLCACSLVAKKKAGEANHDNDNADENDENDENANNNNNNKNNNNATTDTNTNANATTNALPKLPDNDVATVIMGMKLHHSSVRLQLLGCRALKVLLDTERATWDQLVDEGFVSVMMNAMKEFPKDLVLQGLMMSFLGMMIREVNITDNSSSNESDNGNGNDNGNDNGNDNDNDEPQESSLQRELLQLGVVEVILAALQEFEDHTRLVHTGCLALLQITASLQEARQQVVEQNGHLLVYQIMEENKTDELLLIVSLNTLSRLLSVETIDGLPLQQVVQSILECMELYPKDEAVQMHALVSLLRLGEHTRIPTNACIQKIVPAMVFFRHSKSLVFIACVVIRSMIANSLEPASVLQDLLQFGGVECIVHASKDHPSNSGIQQIVQLLLSVLLVHQQTVGVPLAFRGTLRVVGMMSRIDFDSDHDDDDDNNNDDNDNNDGDDNDGEEDEDDGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMT6</accession>
    <name>A0AAD2JMT6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1963307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="260" mass="30021" checksum="95B0C1315E8713A2" modified="2024-05-29" version="1">MIPQALQVTKWISLSAPRIPYSILRYIYFTVAAPGSTGDARAVARCENLVEWINNLPNEAFVGGDNAYQLSDSLVIPFSGAERYEELKRTFNFYLSQLRIRIEMSFGRLSTKWRIFRTKLSFKMDKNIKIIQVASRLHNFVIDQQEIEKIQLQGTESMAQLRTIAAIDRLEGYDKFIGDNLGYLPSERPARLRPRMKDTHVSQNESSDSQNESSESNQSDEESTDEMSVDFETASKRQSILELVEELRLVRPDRNRERNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNI8</accession>
    <name>A0AAD2JNI8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS22544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="734"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="613"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1966965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="800" mass="88366" checksum="3D40A97965B49838" modified="2024-05-29" version="1">MNPQQHHQQQQGESAISASNASNIPTGQPAATASNPISIGPQRPDSAQRNSSRGSQRSSLQLDELGENWAEVTDVWEANVAQPSRKALREFFYPSRQSLQNNDENQQQQSRQQYAEGGGSNAANPSARSANPQTIRNASSPTSNGALSPSTFRQPPPSIAQNPDVIEQERQDKEFVEDFWTIYDDIIILSLFTQIGIICRLGVAYSFRVLDAVFRQGSALFTNLPLNCFSCFVMGLLCSGESLMEIVSTRFSPPRLQHDLHQEARQLLAEQSMDEEDMMDDRSTESLSSTYPRFGGTQARRRKKKNRRIMGWRPKSDDFYSELREVQLLALERRIRASPCLVLFHVRKEDVDLVENYFNNDISNNKNEDTSNQQTGTRTEENDEGNDGERFSLDEHDLVLEETQDDPENRRTFAAGQELSTASLPASKNANKNDQDSSGPIVPGRKRKVRIESRAYAQITQADSTESAATPTNAAAAADPAAQPLDLEQIVSNVATDVSQQISQLSRVTLADGWDVGTTPDDKKKDLMLGLRDGLCGALSSFSSWISAMVSLLRDGKVGEACVGIVIGIQLPIVAYRFGQHVAVCVFVWRCRRETKRDERRGGYGIRLSTDEEDDIQEQEFQSPQSGNLDNPYAEDNSETPSVRAVITALFVISVVAQVTSLNFYYEPDDRLLAFSLLFSPLGVLTRWRLSRYNSWRPNFPIGTFTCNILACALSGTLGNVLAGNPGPTERIALVALIAGFGGTLSSVARFIVEMLAGVDPILLRIDGAYYGMISIFCGLLVSFVFTASGDWADTTGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNZ9</accession>
    <name>A0AAD2JNZ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002265">
        <property type="protein sequence ID" value="CAJ1966205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="137" mass="14998" checksum="8C79678323F7BBC5" modified="2024-05-29" version="1">MMQVPSGMQLMQIPTQGGGTVTVPYSMNANGEIAFSGMQLSRQGFSGAQVRQGFDATQAQTLQAVKNGYFDMSNVFHDAIKGKDENGNDVYLIPCPAGTTNVKLQANWRYASEDEDLPDLATEADRGLQFIQSRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVC5</accession>
    <name>A0AAD2PVC5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVC5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="402" mass="45861" checksum="7A545A4B11C70F47" modified="2024-05-29" version="1">MFSRRNHPRILQYDAESNSVTTQNLETVPNLEPTKAPKEAGSSSSEEDEYEPTCQPMHEWQTRTFPVCNNVHEVNMRPESGSVVFINCGGSRCAFKILDNGNDWVVLKIPKYKKDIEERSFEKARKDGMAMERLQASPYVLDIFGFCGLSQVIEPGLDGGATHDLIKTTRLRGEDTLPVVDKLKIVYQLASGVADMHTFENDGLVSLVHNDICCHQFIFVDGIYKLNDFHLAHFQTKNKTSHEVCKAYNGYSDHYKLIRSPEEISLKVNRPRNQNVLLEKSDVYTLGNVMYYILTMKWLFETQGVSKGIKELMQGRRSPFPEKILKSSDRGIRAIRKAIEMCWKHDPEQRPSADTVRNFLGNELKAVLGVEELGVVRVTSISPLPEGYKYTDGDFRTMFYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVP1</accession>
    <name>A0AAD2PVP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042257581" description="Copper transporter" evidence="3">
        <location>
            <begin position="17"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1956483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49551" checksum="D11C6E9845ED3665" modified="2024-05-29" version="1">MKIALASAFLFSSAMAYEGHKDHAHHRVHGHHGRHGHHGHHGNLREEHPYQDKPHSHIAYHHVEQACAKDVQTFCTAPTAQNPLLIPNMEWAFPSDRELMDIAHTMDQMIESFFSMPPPSSRHHYGTVTIYTPKMIHESPKRATVHDLNFVADSTASQLASQTKPEEIPQLAEKLNMYGEHLMASSEEGKPDHHIGRRLTEVDSNTLESHVRLPFGCHKNACLMHMRSHVSPECARSIKELENISHLEHQLEEHQDAQLMYMFIYFALLMIFLALVIKKARKDMGKHRFGHKILEAVYANPELKRQVELEMGQSVGEQAPVPRMGGRKWKEQVAGMQRMRFFFLLAIVYAFIAAPFMILPICVLAMFVRVMHMCVIVHQKDSDDNDDHEEEEKDDMEKPLLEEYTPPTVGEGQKHSFEPKKEVFNGIRVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVR9</accession>
    <name>A0AAD2PVR9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="172"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="49564" checksum="4F9A9F8B70013312" modified="2024-05-29" version="1">MINDVQSWVIPKTRSSERRFHLRSTSKVNHNGEAPPVTCSSSSIDNNKNTAGAVVWWSDDEFQDWFYHELKEEAGPILHQTYGDELFVDLSHCVTKWRQRYRMGNNNDRNDADDDQQVSMESGDRRVDGGIWKRLFKRDRVVKEVLESIPIIHAIDKYVRSMPPPPSDEGGLNKNKITIVDLCSGKGYLSMILSEYLPPDKVEKFVLIDKAWPMCHAEPKPHHINWDHIYGSYTTAEDGTELKSYFSTWPIPLHTSKQNLKKTSDMRRLQQRLGQTSTGPCFVLGVHLCGTLSIQAVQMFYSVPSIHGLILKPCCLPGMAYEKQQTHFQAGKYAFPTKEVCSPGYWKKKEWEGPPRWHLQGKFDAWCRHLHEAMKYVSDSDVGVVTKLLEAPVQTNGGFQNTFLFAQKEPMTDLMWDEIERSELTLKQLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWS8</accession>
    <name>A0AAD2PWS8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1962006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1962006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1022" mass="115630" checksum="DAE18916FF40C056" modified="2024-05-29" version="1">MKTPVEVRQTLAKIKKNKETLFAVLLAGTRWYTGGLVMPLTFVICRLLLDRLMEQRISSIHRGKLATPEQLAQGDMNAQSLIQSYEEAMRMVDAEAKKNRDIQLEMEFIDSENQRLKALLDEANAQAIVSQYDSPRAAPSGNLQKKIDELEKLRSNLEEELKTERQAKQELESEKREAVAFRDAEARQNKIFKKEIERVKNDTKKMKEMETEISEKNDLIAKRDKAIAQLEQESGKKEQKIGELESNIQQLMATVDSLKEQMANLNESLDKERRVVQSLEGKLEETQQKVTEKGQLYDISMKSYGEEKEKNSSLQTKVIELNDTLDAERVKLQDREATIVARDDVIGRLKGFESKSHELTEELLSTVNELQDTKKRKESTEANLTSTMEKLSAVEEENKQIAVLNEQLDALELCVSEGEAALIAEKASLKTTAQERDATKAQLEDILAEKETLENQHNELKEKYEVVSDAMELLEAEKKTTVRLNGEVDTLTKSLEDSEAKNVSLQHTLNQKITITEAKVTMLAESESMNASLQQEISDLKKQVSKMSVALEDADVKEKRAEEIEAAFEAEKAKSAQLENKLEETTTALDEETTKASKLEKTLLDNKRMIEESEATIGSLEVFKQKAEEESQRAEEMKTEVSRLNNYLGSMRISVDDLQETLQEKENKIAELSAVNATLTTGKDDLASEYTASKAEQKQLHEQLEIMERKLKFENEKLATLSNQNQELKEVNLQSKEKLVQLQSSLSEKDAAIDSKDDEIVQLQNSLDESTSRFTEERSVAVDIAKDLRARNEKLQFKEAEALEKLEELKESSKETIQKLKASFEETKASLQEEQSKVQSLQEKLRSKEAERDEAIGGLTERMDGELADIKKQLADAKSKHEAEKAKVVVLESTRKGSQKMIHDLEAILDKKEILLERRMGEITTLKESLAESVKLCKAREARASEVEEKARKGEYSAELIAEMKTRENHMKKSLDDATQNTLKLKDMLLASGAFHGSTSKGPSLTSPRGKPTPETMSNWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXG3</accession>
    <name>A0AAD2PXG3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXG3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="16825" checksum="E29E504D1ACFAC42" modified="2024-05-29" version="1">MAPNLNHRTSSLHTLDLDLLVQPIKATFPPLTLEVAQQTPMTIESSQQDSSSYWEWSSENDAEINKLVDEEYLSADHIVSNILLSQPAVKASSLSAANDQYWGWSHARTDSVDYWNWNSTSDEQRRRSRVVQVRPASVQETDSYWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXK7</accession>
    <name>A0AAD2PXK7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="162" mass="17899" checksum="2610496EABBE1B02" modified="2024-05-29" version="1">MAPNLKHRPLVLQTAAGLDLQDLKTFPPLTSEAQVPQSQGKAGCGDTTIQTSPKQDSSDYWEWNGDNDVKVQQAMAEEQAAELVCADHIIENIIREAPSAGVVNTTSADNDQYWDWSPAQPAASYWDWPSTKNEQRELVRQFDATQTTTVAAAGASDSYWDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXQ4</accession>
    <name>A0AAD2PXQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002320">
        <property type="protein sequence ID" value="CAJ1967272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40971" checksum="0DDDD05B1ED4D185" modified="2024-05-29" version="1">MEEKKKAILVKAVYGLKKSEIAWRSLCADVLKEQLEFQPYRGDTDVWRRPCQHKDGSKYYEYILVYTDDVIAISENPKAIMDKLNNFFVLKPESIKELTTYLGATISKHKLDGDDYFTWVIGSEAYLQESLRVVKKRIAPMQLTLKKKVYSTLATGYKPELDSTPFVDDDTAILYMQLIGILRWLVELGRINVAAEVSMLSSYNAMPREGHFHAALHIFAYLQKHPDRVLVMDCGYADHLRPLKKADYSQFYDFTKDELPSDMPTPLGKAVEFTMFVDASHAANVVTCQSRTGVLIFVNKAPIIWYLKKQNSVKTSSFGSEFAALKTGVQLLEGLRFKLRMMGVTICPLSRTQVFLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAE9</accession>
    <name>A0AAD2CAE9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1903596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAE9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001202">
        <property type="entry name" value="Translation elongation factor EF-1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="175"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1903596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="615" mass="67700" checksum="3188B7E2AC137B6B" modified="2024-05-29" version="1">MNAGAPEWKPNAGAASWTPGGTPSFTVATPSPAAAPAPAPEPAPAPPAHQDSTASDIDEKDPLWQVVLKIAEGDRARALKMINNPDSLTKYPEVVAILASGDGGGDAMETDDWEKEKSTDGDLAKQVDEKMKIDEKPKPKPAPKEDYDDDDDDDDDDDEEREEVDPASLQEGDPREHLNLVFIGHVDAGKSTLSGNILYLTENVDKRTIERYEKEAKERNRESWFLAFIMDTNEEERAKGKTVEVGKAHFETSDKRYTIMDAPGHKNYVPNMIMGASQADVGVLVVSARKGEFEAGFDRGGQTREHAMLAKTLGVTYLVVVVNKMDDPTVNWSKDRYDECVTTIRPYLKRCGFVIKREVKFLPISGLNGANVKDEVSESDCPWWKKCWNEGANNTTAPTLLDLFDTLQIKDRDPSAPLRIPVLERYNDRGTIAMGKVESGIVRPGMMVTLMPTGNQYKVDGVWANEDPVSGARPGENVLVKLNGAGLEDCRKGFVICSDPPCRAVDKIICKIAVTDMPDNNRILTAGFQAVFHAHCCEEECTVTKIFETTNNKGIVVKGARFASEGMQCVCMLELDRSAPVETFETMPFLGRFTLRTEGKTIAIGKITKLPPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAZ4</accession>
    <name>A0AAD2CAZ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1911241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="58"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="176"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1911241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="285" mass="31837" checksum="1F775E19D400C5A8" modified="2024-05-29" version="1">MLSGLFGQLDSLTGIEGTFGYIVVIIVTVLGHNYMNPPHPPMPAAEEEKDEPEPPRNFTEKQLSYFDGKNDEKTDEPKPVYLSVHGIVFDVSDGRNFYGPDGPYEAFAGHECGVALAKMSFDKEHLDNLDGCDKLNHGEKTELEGWIEKFKYYRNYPEKGRLVPDSKLETLKDRVIDPKDLSKHKGEDGEEVPEGYATAPIYVALGTKVFDASFGGVEHYGAKGGYNKFAGRDVSRALAKMSFDPADLENTSTDDLEEKQLKVLADWIKTFEEKKAYPIVGKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBG9</accession>
    <name>A0AAD2CBG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS98</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1892544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1892544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="112" mass="12372" checksum="6833190B7850B332" modified="2024-05-29" version="1">MLMNNDSFNSSSYSSQHQQSTKHYFQSIKASGEVAKSSDDGSHPTHSSSTGLRMAHGAICPETIAIFEKNSNPAIRRFVDTYHKRGPLACEDLLSDPEVLPHLTKAMRDIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBL3</accession>
    <name>A0AAD2CBL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS1092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBL3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="346"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1924592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="652" mass="74436" checksum="8F975FAE21545993" modified="2024-05-29" version="1">MSSDPQPKDDEADDKGENCLVEKCAEVDETERTLGISEYLTSGKGFSAVMKARYADFLVHEVGLDGKIAKLTDTTVPTSSNQSQTETKAKEEAKKEEAKREEVSSGRKPYDWPALQSQLVDMIKDESIAEKLMHILQTHNKKEDCEEKYITMPALEKDQRRFVHEWVRNSVPCARSDSADGHIRIWHCKFEKEMSNYKTFADPRKKKRKMEWPKDRPDFLQFVLYKENVDTTTAVKDLSRKGGKARIGYAGMKDKRGITTQFCTLYRIEPQQIASRRNASGGGNTNQRGYSVVQVGNFEYVSEELRLGRLTGNRFDIVLRNVQRTDDDSVQKEQLLEAAKSMKEKGFVNYFGTQRFGKYNDTHKVGVAVLQGDYKKAADIIMEPKPGDRKDAAEGRLDWQNRFEKGESAEAEAECAKRVIRSLNRFMTAETSLMQSLSRKPLDYKRAFSCIPKNLRMMFVHAVQSLIWNKAASFRVSSMDKDNVMVGDLVLGEGRGNTKTITQEDIDKGTYTLDDIVAPLIGTKSVLPENELGEFMKTKMESELGVTVDMFKKIQDKDLAIYGDYRKIFCRPKDFDYDVKEYFDPLQPLLQTDLMKLNDENVEIKPKSEEHNQLKVAMVVGFTLPSSSYATIAVRELTKRPTSNEYQKELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBR7</accession>
    <name>A0AAD2CBR7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1926185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBR7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1926185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="309" mass="34679" checksum="F491B502D34737C5" modified="2024-05-29" version="1" fragment="single">QLLATVQDAERRELLDDIRAIELRIERGVCPSRVAKAHSVWTTCVAFCDSLTLDPGLSAVDDPLLIILLFGTQWRRGKIAPRKRQVRGRTAEDAMRQVGQAFSSLGLLYPRMNRYAPGTMNFPWTRLLKSWKKEDPAAQRVHPLPKSLLRQASKLATKPTSTHAAKAMNRLMWLGFSFLLRPGEFLSKAGTQFPFKLKQVFFCINDAEFRGDVIPLRLLDTSLVTFAGLIFEKPKNAVPDEKIGLGTSFNADNPTATLIAIVRHLQQSQHTTGDTPLFTYYSEFGVPCNVTDQMMTKYLRAVALSVEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBS5</accession>
    <name>A0AAD2CBS5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1899543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46277:SF3">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46277">
        <property type="entry name" value="OS03G0850700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="212"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1899543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40552" checksum="5C668FD13C06CAA8" modified="2024-05-29" version="1">MAMNPVFHSTSSEKPKLLTISFKDDPQGSLGAQLINCDKGEAFEMFSPGFAQIGRLLEGATVARKCGVNVGDCIVAVNGSGYRRFAADFKEEELENLSGDSHMSNDNNVFTAGTGEAYLALLAKIKFIKSMGDPPLALSLERYGWDAKINSWPRFLEARDGDVPNAMKMMQEHEQWKTGIFPIDLTRDGVQEVLRLKAVAEIDLDVMETQVPTVYVNFSKLQSVDSISPDDVCKAFIVFTEMMLARGKDPRNPKANQFIDLSGVTISSGFRVDMLKKIYNLFEPNYPETLQKMVMYPVSNMLAKTARTLLNFVNEKTQRKFVITNSLAVVCEELGWDQREVESCGGVTEFMHKHEKAGSALILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC24</accession>
    <name>A0AAD2CC24_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000026">
        <property type="protein sequence ID" value="CAJ1927947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CC24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1927947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="154" mass="17423" checksum="6B713FA973CF25D7" modified="2024-05-29" version="1">MDRTPIFMDHSLLDHLNQQSTLLGFGALFKECQVPEVGNEKEVFFSDYCTDQMERKKQEGVVASTKVCLCDDCKDKYESPQTTSVARRRSGIARVVDRSAAQPLPQQHMQQQAADHSTLLQCQAISPPVLPTIQLSILFMLQRPVFFLLQINLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE99</accession>
    <name>A0AAD2CE99_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="429" mass="48474" checksum="000BC774AB95A5E8" modified="2024-05-29" version="1">MAAPIDDARYFSTKLLDRYTLPSRESLVSFAADVTEHCSSQASDDDSSSERHNLGSLYGDALGPQVYVRLQWAIRRETSFDKRKNNLALAKKYAEESLEYTLASSSAKRRVALLESRWVGSMTMLIAIESRMENMENQRDQVCQQLLRRLTRNCQGLPSQECEVLYGRAGAIQAILWLRGELQLPSMGRSFCLDMAEHVLQVGIDNASAAPQLQLPLVWYWYDKIYLGAAHGIVGILQTLLQLESKELIELERRVPNALQIMEQTIDALCQFYCFDESGNLMSSVGNNNKKDRLVHWCHGAPGWILLLILASKVLSKPSNLELAKITAVQTLWNRGLLKKGLGLCHGIAGNGFVLLRLSHALEGDEQNLWYHRALQYASFGMAHYDRLKEIPDQPFSLYEGLSGFVCFLLACADHNDSRSSQFPLYEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEZ6</accession>
    <name>A0AAD2CEZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CYCCA115_LOCUS2744</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040000213">
        <property type="protein sequence ID" value="CAJ1932219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.380:FF:000001">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="16">
        <location>
            <begin position="87"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="772"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Valyl-tRNA synthetase tRNA-binding arm" evidence="18">
        <location>
            <begin position="986"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAJ1932219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1059" mass="119920" checksum="1B141A963C3E478E" modified="2024-05-29" version="1">MTEPAPAPAAAEGEPKLSKNQLKKLAKGKGKKKEKPQWNLDKKKEAPKKKVEKKEPFVNPTPKGEKKDMSKLPFADSYDPTAVEASWQEWWEASDFYKGNTEYALTKSQEEKFVMVIPPPNVTGSLHLGHALTAAVEDTLTRWHRMKGHATLYVPGTDHAGIATQSIVEKMLMKNENKTRHDLGREEFIKKVWEWKGDYGNKITTQLRSLGSSVDWSRERFTMDDMLSKAVCEAFNRFHEKGLLYRANRLGNWSCALKSAISDIEVDYIDLEGRTFLEVKTHKGNPNDPKGRYEFGTITSFAYPIEDSDEQLVVATTRLETMLGDSAVAVHPEDPRYKHLHGKKVVHPFSGRKIPIITDPELVDMNFGTGAVKITPAHDPNDYECGKRHGLEFITVLTSDGAINHHGGDEFQGLMRYDARIAMEEALDKKGLLKGKEPNKMRLGLCSRSGDILEPMITPQWYVNCSGMAKRSTDAVRNGELKIIPADHEKTWFNWLDNIRDWCISRQLWWGHQIPAWFATTKAEGETITKNDMAHNDRWIVARSEADAKEKALKLLGCTEDELVLERDADVLDTWFSSGLFPFSVMGWPDDTADLKAFYPTSLLETGLDILFFWVARMVMMGLELTDTLPFHTVFLHAMVRDKEGRKMSKSLGNVIDPLEVINGCSLDALQSRLDSGNLPEKEVARAKKNNQLEFPDGIPECGSDALRFGLLAYTVQGRDINLDVKVVVAYRNFCNKLWNATRFALRYLEDFAPTATLMEDLMSSGKMANRDKYMISRLMKGVEAVNDNFTNYKFGDAQQAAYQLWMNDLCAVYLELIKPIMNDTSEEKKDARWAAQATLWVSLEAGLRLLHPMMPFVTEELWQRLPGRGTLGESEKPSIMLAPYPECKEEYKNEALESAMTTIMDVVGACRSLRSSYNINNKVLTHFFVKTMDAEEIVKAQIDDIITLGKASKVDVNIDNIPESVGTSVVNDNLTVLIDLKGMVDYKKEIARLNKEMKKTKGPLEQLEKKMASDGYIEKVPEDLKKENVEKQEAYKKKVIDIEEAIANFEKLLSLEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFV7</accession>
    <name>A0AAD2CFV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MORN repeat-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000014">
        <property type="protein sequence ID" value="CAJ1927234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFV7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1927234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28967" checksum="5012F37D8A22F8DE" modified="2024-05-29" version="1">MSYSNIDDVYVRDNTDSGEGSYTGFVCKHTLLPHGQGCMKYFGRDNNLVSYDGEWDQGIWHGYGSLMFQSQDCYVGEFQNGSREGNGTYMWQDGSQYEGRFEQDARTGKGRFTWPDGNFYKGEFVNGKREGLGQYTFLKSGDMYSGHWKDGHYDGFGVFTWSDGRTYRGNWKNSQRHGKGTESDCDGNVVYNGMWENHHPVVSDKDYKEKVAAKEEEGESPTTTTFATPGTTTTTTNPPPARNIPFPSQQSHRTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG01</accession>
    <name>A0AAD2CG01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000296">
        <property type="protein sequence ID" value="CAJ1933724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG01"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="159" mass="18048" checksum="E9DE45FDC60B17CA" modified="2024-05-29" version="1" fragment="single">MATVRKNKEGFTPRQVKAAMEARSAMHILNAPSTKSLKYAIQSGLIKNCPITEEAINHAKAIFGPDASTLKGKPTRPTLKKTYDDFFGPPEELYQHNRSITVCIDHMEIENAKFLTFIDTTVRYRSCIPVQNLKTDPVFEALDKIFRRYNKAGFQVKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG08</accession>
    <name>A0AAD2CG08_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000153">
        <property type="protein sequence ID" value="CAJ1931493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="150" mass="16666" checksum="AA6544C0E59FF773" modified="2024-05-29" version="1">MMLFQLNNTGIHLDSGSTFHLRTNEDDFKEGSLQGIHGGFHYASNVDGRNLYREGIDKVFDSVCKLDTRASDNINSLSNMVKDGFDVFMDTKRENSFFVTRNGTTWQFGHGNGLYTLVDEPAATAGSSTKEKRKTKSTEPIGTLQTVFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG82</accession>
    <name>A0AAD2CG82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS3057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1932877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="32861" checksum="7670CE3E4347DC6D" modified="2024-05-29" version="1">MAIKNPLTKAIFAEFIATALFVWIGCGSAIATNKWGAVSSGADLLTIAIAFGFAITLLAYSIGGVSGGHINPAVSFAVFIVGGIDFKTMACYILAQFGGAVTGALLLWGCAISLTLACDDYEDPSSVPVCAASALPDGRDGYGPPFGLGVNSLSPRVGLGSGFMIEVMGTYLLVFTVCMSAIHKKSAAGNAAPIAIGWSVMMAHIVLVPFTGCGINPARSFGPMFINSIGGVNPWTKGWWIYYVAPFVGAAIAAMTYKIIFAEEEEEQVKEGGSLATEAEHERKPSVDDIEVGKESLAANIYKNAFAEDEEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHL2</accession>
    <name>A0AAD2CHL2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000275">
        <property type="protein sequence ID" value="CAJ1933481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHL2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="420" mass="46829" checksum="1A8253DA1769324A" modified="2024-05-29" version="1">MLYDLCDYCQFIYMVDRQHDPAFGTQANLAKINRYYSHLKNKSNEFEDISEVMPPKFDNKNTVKLMESLEQWLKRNRGKGGTLLTYVIHEHQNPDDNPTADPGFLMPSVEDEAIRRSLHREDQFVANNKAVWNMLYSVCHGTDAWPVIKGYKTTENGRQAYLDLVAHYQGEGQLNKRRDSAYRILNTTHYNGKNNFSFEKFAARVLGAFEDLKNCGDGMSEHAKVSMIKEGPQGAGLDACKTLGRGSQACMQNLRTAINTLQTEDTAQQTHRLTATSGTRALAAVNGGGRNSNRGRDRGRDCDNGGHDRGGHNRNRNQHGRGGGRGRGGSRDHDGTVWSNDGTTILNNGGYSQDTWSCFSDRDRRVVLQARERANSCLMSERDIAELNTLREQNCDHQQNEEPAPTPAPAPSSGNVGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI63</accession>
    <name>A0AAD2CI63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000304">
        <property type="protein sequence ID" value="CAJ1933831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1933831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="296" mass="32373" checksum="0B816C9D7B03FEED" modified="2024-05-29" version="1">MKKSADAEYNFLDFWEANQKFFAMKQGTNKNLMHCKEQFLRQAEVLQDLYGVAWFRDFAVKTKAYAAIASTDTAAQNKFKDDIFEAVLATGFLCNSDRTRTAPLMLDLQTNYCREVDYYPKTVSKAQDMLKIHMEVSKNPGVNLYQGKDQPNKGKGKGKGKGKPKDGKKAACYVCGNKDHMSPKCPDRLLPKTQWKNQDQYVDYGKKLNLNQIGATVPATIPAIVPGASASTSGASSVAGSVNTPLRLAGTTGNQMMQVPSGMQLMQIPTQGGGTVTVGLHDNGVPLEGIWGVLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIP5</accession>
    <name>A0AAD2CIP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS4415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041934406" description="Methyltransferase small domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase small" evidence="6">
        <location>
            <begin position="277"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1935077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="548" mass="60378" checksum="DE29C2D99422DFD1" modified="2024-05-29" version="1">MQQNPGKFISFAILLLWLILWTPACQSSTVKLQQQQQQQQQQQYAKARQVRALFGHDAAQPLYEELLATNPADTTAATRVASNPNARMVHSLLGTAGTKQERLAFTNKLGQLQFRPVPISQEIFGGGESCSRAAKSASRSSAPLYLKPLRAGAVPPPLPESPLVACIQLLLLAVCLPTRHCVNLLGGETVALMETLGIVYREKFSDNTHDDWLVPYCHVMPVRVEEGTVYIATDLHPDVLSTTTVPNGDGTVMYIGPDSLALLDHCNLQNGWISSPENMRIVDIGCGSGIQALRLSASSQRNTENQVTSVDVNPRALAITRLNFEWNGLETPSLVLGDITQSAGGSIVIDDNEDKSTTWQSVFNGVTHILSNPPFLPVPVQDDQISKRYGLFSSGGASGEEVLRRIAELAAESCSNNSEVKLAIVSEFMNPDERFSSKLQEWWKNGGNPKAEAFFFCNQEPLTAEEYSQRRADSDEETDKWIRHLKGEDITTVSPGLLYMQSLFSNKSTEADLRVHHHCVPKTDQGSIWTPTNEKARQSTQEVMDSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJA4</accession>
    <name>A0AAD2CJA4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000269">
        <property type="protein sequence ID" value="CAJ1933422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="167" mass="18579" checksum="DE74A13DE2B3FFDA" modified="2024-05-29" version="1">MALLAEETKIDERDYKLLEELCTEVLETAKEEAKALATSKPAPEEAALSSRANRTFLKENLLRHHIEHGKVFYLEKEGSGAIQLAHPKASGLVAIQSSSKSAGDVKMDNQQCVSLLIEQGTSVDSLEGKMEVAIVEAFRLEDNKMIQKLIKKKPSYIHYQLGQVQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJM2</accession>
    <name>A0AAD2CJM2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000386">
        <property type="protein sequence ID" value="CAJ1934793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJM2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="117" mass="13970" checksum="63A222FDB26F0098" modified="2024-05-29" version="1">MVAKCPEGRPAREADELEDEMFDRMFKKIKARQDADYLMDEDYQEHEWITANEDMDYEEYESELDNEETKQMLDKLAAELVELGKPYEEEVLFEFDDDTQEDVAVNQKRKMVSLVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKN9</accession>
    <name>A0AAD2CKN9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000580">
        <property type="protein sequence ID" value="CAJ1936949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKN9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042024695" evidence="2">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="155" mass="16645" checksum="5F5D55373C5A1238" modified="2024-05-29" version="1">MTSTLRAVLLIVSLSLTALAFPQPKPSYGGGAGVGRLILDDEKAKQYACCYDMVLVERLQKRKAPQDTEDGRLYVPDEDLPRLHLCKVLSVGPGREEENGSVAPNLDNLKPGDLVIAKQPWGIGPKDEELSDGTKLSYMRGLDVAAVIPGGSVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKR5</accession>
    <name>A0AAD2CKR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000476">
        <property type="protein sequence ID" value="CAJ1935468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="179" mass="20668" checksum="0F37A991A3A41AEB" modified="2024-05-29" version="1">MKAHDRAEFIKAMYKELGDHIGRKNWKVVPIKSIPTYSGKRAIPMVWAMKRKKNPLGEIIKWKASLCAGGHRSIENVDYWDTYAPVVSWSTVRLMVIFALINNWHMESIDFVLAYPQAPIKTDIFMQPPRVPPKFVIPDMPRPGDRFTSVYKLLQNLYGLKDAGRTWGQFLHKGLIDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLI3</accession>
    <name>A0AAD2CLI3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000324">
        <property type="protein sequence ID" value="CAJ1934037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLI3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041961958" evidence="2">
        <location>
            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="179" mass="19913" checksum="E2A70F5619867669" modified="2024-05-29" version="1">MTRLSNTIIVLLGTSLVPSSMAFSSMEQQAKKQQRRSISWSEYKHDFIDPIASGQGHDSNLEGHMDPAQRQSSDQFWLAYYAQEKERLHELNSHASAQQQESSSSSSSSGLPRSASSKVTSYDVYKSKYLDPMLKNEAHPSGLDGPHLDPETRASADEFWLQVVLEEKAKLHGKSSATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLM1</accession>
    <name>A0AAD2CLM1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042150383" evidence="1">
        <location>
            <begin position="16"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="174" mass="18904" checksum="2A6C2DC3CCE1CF4F" modified="2024-05-29" version="1">MRSFTALFLLPLASAFAPTTTQLNTHAIQSSFLQMAKFEIEVDMPPSDSNMRASLKFDPILDVPSEIVEVRYQVPFGLNVEPQKNLAVCTKDGEGGEKVGDVLRYTSQWTLGLPSGGGVIATVASFGGGVSWGCSMFNVMNAKAWEQVVEALVSNVESRTDEVVLIFERPLAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLQ8</accession>
    <name>A0AAD2CLQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS1074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLQ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="10">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1924233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="287" mass="31387" checksum="5F3BD8A3B1CF782C" modified="2024-05-29" version="1">MLRTRSSTYKSSSPSSTVIIHDRFFATIADTAASDAAAAAPEKMSGMSDQKRRLAQAALQQIPKYGWTQDALTSAVMEDPQMSVSMTGLWTPIELVNWLMDDWNSQLQEKQIHDSQRMSAFDAIQWRLQQVIPLVKASRWHEGMALGLSTPVTTRSQLHDFVELAAPKDATMAYKTGLGSIFLSTELFMLTDSSEDFEATWEFLRNRLTELDNGKMVHFVDMNQIMSTISTGAGNLSSSGSGTNVPIAAASAIASSLLEGAASLLRPPTRSSTSHRSGTKASDYKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM36</accession>
    <name>A0AAD2CM36_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="880" mass="98051" checksum="30CDF841DFBB8846" modified="2024-05-29" version="1">MILGQSPRRSSSLRIFVPRKGQQQIFRRSQGSRIIQKSHKRHLHDGQNDKKHQTPISVATPLVFAPKPSSKQSIHSLKGTASILDPKWAHLSPCIGAALSTSPLIGNLIKLASRYSPENDDSSATDHDDDDDDDDDDNESSPSSHHRKRLYDTATLANQVFFQIMPESSLFLKRTKSMPAAYLTPRLIGTIVGRSTIVAKAMDINTIRDYLRNEFDIRSNKIGNKWTGVSLNRWVDLFRLSSHHHHHHHHHHHHHHHHHHHHEEEEEEEEASTTPNLDWMPLSIWSVALWEVSHNLPPDNTQTPQESWLEYLLECDAHVQQQFGSDESIFRKEDDLAQALKRRDPSAMKKWQEQTFCANRDLREANFQDSMDQLLEIWEGTTTSCDGLSSEDWTKASLALEIVCASVALGQKVSGSGTISAPSNGKKDTTKLSDKPVVPNGYFSVDEGDLKADCVEVTIREIIDLLLWNEDIGAMDLLRLPSTASADLKIFYERLDQPEAAAFDVGQEWFNILSGLPGCDYLAVGKVRGIPYELAPTMDNVARVCQSLVMHGGTNAPDSTTGLGSISEESSHWKSLEDVANGWKGGPPLHVQSDALIHQDASNPGGDSKKYEIATLQVEGNPNCIEIRMRCDWAQKSGFSAVTHLKEGRSIYDNKRKETMRSLLQSKGANATKSFSFGQLGNLLALSQNSDLGLLSPLVVKNKDKGDLDLLLLDLLVTRFGCDRRGIVSHFSNSDPMQQRARQQEFDRQQTEQNHDLLRSALHQICDLCDHDRELCKMLLISFLQESADVVESSSGNATGTVDVDESLEVKIASLPQDILSSSLAQQALWNSRSGIIRGKVLAACAELKSGTISWWDVLLSDFSPSEIISVLALLRASHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNK7</accession>
    <name>A0AAD2CNK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000624">
        <property type="protein sequence ID" value="CAJ1937291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052530">
        <property type="entry name" value="NAD(P)H_nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43821">
        <property type="entry name" value="NAD(P)H NITROREDUCTASE YDJA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43821:SF1">
        <property type="entry name" value="NAD(P)H NITROREDUCTASE YDJA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="241" mass="26468" checksum="0EBD6D8631CF82B0" modified="2024-05-29" version="1">MQSLLQSRRTGTSMVFTLEDHQKEEGLLKEAIHRAVQCAQMAPNHKRTEPFSFLQIMNSSSSADQVAEIAYQVAARTRSVPVARKKKEKWSQIPAFLVTLVHKNQKAVLSDSSSGGSSSSSSRSDTVDEISDGTFEPLPYAPPETERQLEDYASASAAIQNVLLSLHADGIATKWATGPVICTPAFRKLVHAKPTDRIAGLIMVGGMDSTQFDSDKMEQITAARRRRRRDVDGDVLQSLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNX6</accession>
    <name>A0AAD2CNX6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="178" mass="20209" checksum="30BECDCF5585E0C7" modified="2024-05-29" version="1">MDDYNTTEQRRGSMFGGARRGSFFGGWAVDDGEKSPEATAHRRASLQDRYRGMEHATQRRGSLFVNHHHHHSSENHPTEKQGRRSSFFGNLHHHETSEEEKVDDGHHHRRSSISFFSHHNHNRRGSVGPMATLSSVTAKSRRGSMGFFSGLNKIHAIEQPNNEDLAYQVMAAFADFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP80</accession>
    <name>A0AAD2CP80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS6897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="3223"/>
            <end position="3794"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="4098"/>
            <end position="4428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2203"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2451"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2574"/>
            <end position="2600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2778"/>
            <end position="2801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2820"/>
            <end position="2843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2203"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2216"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2574"/>
            <end position="2585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2820"/>
            <end position="2833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1940152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4463" mass="502337" checksum="73856A6407D9BE46" modified="2024-05-29" version="1">[encoded data, 4463 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPR2</accession>
    <name>A0AAD2CPR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000968">
        <property type="protein sequence ID" value="CAJ1940870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="209"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="41512" checksum="F07C61869CC3F95D" modified="2024-05-29" version="1">MRAGLQVPKKGAMPPSNESTNKLKRTMPEPEGVPQQSNKRVRMETGVSEPMHINDDDMIGNSTPGETNKLQQPDESTSPVPHNEEEAGRSDPPMEDGGERQPESQQVPNTSSISHPAETILKVMAAELSSATKNGIEGEIFCFEAMFPAYSGEAEQDPLKIFKATSDPDTMYMHEAMREKDAGEFRKAMKKEWEDQLKNENFSIIHRTSVPEGATIFPTVWQMKRKRDIRTREVKKYKARLNFDGSKMKYGRDYDQTYAPVASWNSIRTLLIVSAMLGWKTKQIDYVLAFPQAPVERELYMKLPAGFKVVDGNSNEYILKLHQNIYGGKAASRVWYQYLTKVLVDKLEFKKSNYDECVFYKGNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQM4</accession>
    <name>A0AAD2CQM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000793">
        <property type="protein sequence ID" value="CAJ1939462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="138" mass="15467" checksum="F5B8865E2AAA1AC9" modified="2024-05-29" version="1">MGKSKNNKKVAIAAKPVNSTALTQGRISFSQKSRVKTAEIRSKKVSDNLDPPIHNNNNSDINMEEVEHPLKYDRIVPNIDLSQWNLQTLAYLCTIHWDTPRIGVKPISDGTREEFLHPCSTGLSNSSSTMYVHHLRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR72</accession>
    <name>A0AAD2CR72_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001046">
        <property type="protein sequence ID" value="CAJ1941632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR72"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="215" mass="24151" checksum="28226BDB6EF9C6CB" modified="2024-05-29" version="1">MPPSMPSICHCGDWSMEHVFDAYFKMLSTGDQYLGQILAGKDPNLASFKVLPPHWNVENPLQDLRICTALLKNFWKILEDHGEHGEGSYDPTGLLLCCLACMVWHSKEILDVINSNPSHKLSMVPLFQPDSNLEELRALVSTDPTPGVMTTVTGIPPHIEVACQLKNMRKDLLDLIKATEKNKKDRKAAEKEFREQITNAVQESIEQENVNNGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSL7</accession>
    <name>A0AAD2CSL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSL7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042273513" description="Pseudouridine synthase RsuA/RluA-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="81"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="330" mass="36667" checksum="C799FDDA9D4537B4" modified="2024-05-29" version="1">MSLVRFWQSIIILFGLHKEVGAFVSNGAKLRQNLFLQNSFGVNKYHASLQATKSSDEISAFSIDLPDNIPDISILYESDRILIVDKPSGISHHNDEADAPGVVTVVRHQQQKRLWGVHRLDKVTSGILIFAKDAEMASHLATAFAEGKIQKIYVGVSAKLKPKKRQGWVKGGMSRSRNKSWKLIRDPKDKENFAKTRFFTAKLSPKYESDQVQDDDDSTRKFTCILFRPFTGRTHQLRVAAKSVGLALLGDPIYKDGQDDIVSERTYLHASGISIPSIAGEAEVNLWNPPPFESLAGKSELDSVLSVLMQKHCDLPNLLDAASPGLKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWB6</accession>
    <name>A0AAD2CWB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF95">
        <property type="entry name" value="CYTOCHROME B5 TYPE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="91"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="281"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1939049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="377" mass="41371" checksum="30D581EBA73BA39A" modified="2024-05-29" version="1">MKASKGRRHRDEEMASSRKSSHRHVPRSVRRPLFEEDMQDFQRRKRPVYARLIALMLGMVTLVAAGFGAYFFLEKDEIVLQKGKSQHDNFQGVVAMETIVEHTQPEDCWMSIHGKVYDMTEYAPVHPGPPSLITNHCGTDATNAYDIFHSISLLPIVNEYLLGTLEEITTSPPTSSPSSVPSMVPTTSPPSRSPTASPSTSPPTRSPTISPSAAPSMRPTTPRPTEPEATPFPTSSPSTSPPTKTPTPPPTMRPTPSPTRPPTPSPTNRPTPRPTDQGCTMEFYTMSDVAQHPNSGSCWYALYGVVFDFTNYIDRHPGGRRTALAGCGIDSKSAYESESGHNRNLLRRYSSYIIGRVGTTRTTGTVPCNEVDLVAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWV9</accession>
    <name>A0AAD2CWV9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000824">
        <property type="protein sequence ID" value="CAJ1939660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWV9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="17280" checksum="5BF001D7DD66925F" modified="2024-05-29" version="1">MLPHYQYEHYYDQLCECCENEMVSQDERLEEGGECKKCHKTMCEDCREGELCDECEETICDNCAGSCEFCPNVKFCEDCLGEHKQGCSRLTRAERKLEKLNESVESKKWEQADLKRRLKEISQELDDANEEKANAELKLKKLRQRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZ44</accession>
    <name>A0AAD2CZ44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS8307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZ44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041964318" description="Bicarbonate transporter-like transmembrane domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="119"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="315"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1943162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="571" mass="62868" checksum="E0DAB253C3508CB2" modified="2024-05-29" version="1">MAIVGHLGCPLALLMILMTNVSSCFSFQQTLPITPHVRTSIGAIYHSGPASDWSSLNLGGLSGLRSSAGHRSDGPRIHGNGRRKAASLSLAKGFFENLESQSGKDYEWIAARPPLSRVMIRDILRRKECYISDWTDGLKDMKKVVPAILFLYFACLAPAISFGTIASQITKNSMGVVEFLLSAGTSGMAYSILCGQPMAFIAPTGLTLAFISGLFRFCSLKGLPFFPIYSWVGLWTSFFFTVLGLAGSSQLIRYCTRFTDEIFNALLSLNFIYEALASLRRNFKQADPMNLTMPFVSLGMALTTFFATMSVTAFESRGRNFLIPLNDVPIKIKLLCSLPAVLLTALFYMDQNISVRVVNNPDNGLKKGAAYNLDMVALGLITGVLSIFGLPWMCGATVQSMNHVRALTETQFNPETEEVEIVSVTETRLTGFVIHALMASSLLLLPVIRLVPIPVVSGVFLFLGRKLMSGNSFLKRCRDSFVEKKRLPLDHPMQKLGRKRMSAFTLVQILCLAGLWSFKQNPSTAIFFPSVIGMLMVVRSAVLPKFFSEEELTELGDATPSKHTDEDEINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC06</accession>
    <name>A0AAD2FC06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS1783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040000099">
        <property type="protein sequence ID" value="CAJ1929866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1929866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="328" mass="36996" checksum="F6AB82116238C239" modified="2024-05-29" version="1">MGPSRNDFLFGPTIGQGTFSNVIYAKHKKSGVEVAIKVIDQFTLKRRPEMVNMVWTEQDSLRRCRSPCVINLLAFFSDSDFVYMVQDLAFGGDLHMLLRFGLSSNRILWYQSISYYCRQIVDAISYVHTENIVHGDVKPQNILHDGRGKLRLADFGSSFTCDAQRATQIAVGTSEYSSPEVLTSCRLSIAIDFWSVGCVFFAMFVGESPFRAASEALVVESVIDYTNGKSKVAKDVTTKLPTSWKLIVDGLLNTNPVDRGKEWDGVIKVSRNWNEPEELLALEAPWRRNLEGASLKDGSLFYQPGIPLPEYVGRFILFDEHCRQDHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC26</accession>
    <name>A0AAD2FC26_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1910943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1910943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="715" mass="79063" checksum="DD2C35648036DFF5" modified="2024-05-29" version="1">MALRAFHDNPCIGGFGGESTVAIRSSESGDDHEERSKSGDALCQIIKELVDNAVDACKSKDGGQRVKVEIFPYEYDAQILKIQVSDTGVGMEDIQKSVEAFESSKGRSKNKTAGRYGVGLTLCMLHAQRLVSNSYCCITSATKDQKAYTRAFFVVDTDGNSVVCKKVEKLEKPSSDESGTCVSVLVPGGATAETAWPRVENYFTRFHLRPMTTNAGPNLEVLAPTLSKQPIFVISPSNRVDSGVDDDLVGAGEEQYEDDLEDEANNDSSQRQGKPLTPAQLRLEAQRKAAFHAAQSLFGCNVKLENVAHAVQPIRIPNNNNKKGLMEAPPKLEVDIIVRPDCTESLVGKEEPIATLRLIRMVNSVPMLDSAEGFGCGLVHGLANKLIWASFGLHVTQSNERNEQSWTPLFDVRDSDQVASFFQQRQHRQSDEIIRSTTDGNCVDDEKKTPGNNKRKQRSSDAANLLPAKVRLGDITVVVRIQAAPTTMPLPTLSKGRLPLNHSHIDVALQRCLRESLRSLQKTNTQLLLTPTQLRSTVREVRYIPALALAVSQIISRGADSEGSQQVLDDIHHWRNHHRNDKGKVRHTDISDLHLGEATICTFTEERLRCMLEAKQARIQERKVKKSRTAHVQVEENEYSDLDESDDGDEEEVVNYPRAASLHDEPSDFAEIFQNPPSVCPSSPECSSAAINETPEKASHRGSSPQHSVVDDDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCD8</accession>
    <name>A0AAD2FCD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sugar-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1912643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF8">
        <property type="entry name" value="HAD SUPERFAMILY HYDROLASE-LIKE, TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042285928" description="Sugar-phosphatase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1912643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="60188" checksum="12FFFD0EB05DF126" modified="2024-05-29" version="1">MHGLWILQSFTLLILSRICSASSFAPAKQTTHHALHISSSSLSAGATGDDDDDDDEKNDEFLERLTQQYLGSNHQLPEGKGSKRLGDLYDPEELSNLLNVHKDISSRAQEIQEEEEPSDEMAIPSIHDLVMEAVGETPDPSSTDENDNNNNNDEVVERLTKQYLGSNPGAGLSKDDGEKGGNRLADFYDADTINNLLELHTGVSAQTQDIQKDSTDDAGQAETAVRSSIHDLVLGAGGDTAPPPLEVVSSKEEPKEESSSSSSSSSTTDPEYTWLTEAIREKMNGVKAIASDVDGTLIGSASQTVHPRTKDAVSKAVQDSFSPLGKLKWFFPATGKTRWGAMNSLGPELAGLLQQCPGVFIQGLYCMVGNTVVFERKLPKSAIEAAENLVAKTQTSIIAYDGDHLYTTKITPQVRELHQIYGEPMSEEIPSIAGHAPGIHKLLIYDDDLDKIAEVRIELEALAKEHGATVTQAIPTMLELLPEGCSKALGVQKVCEVLGLDPTTDLMALGDAENDVEMLQLAAVGVCVGNGSKLAKDAADIVLEETSDEGAAGLAIEVLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDK8</accession>
    <name>A0AAD2FDK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000291">
        <property type="protein sequence ID" value="CAJ1933646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="297" mass="33203" checksum="718A27B51B3F969E" modified="2024-05-29" version="1">MMLQKQSDKSFVLPEAGTESTDSSSDVSFQSASLRTADCDESSPTLSPLKHCVTIGSTDSKDILSLMNRRNGNPRDNVFTTSSRKLSDRRVSEMFLKERRMSLYDSYARSSSKSFFVDDLQTLFDAPEEEEDATSSSTPSSVISINKTCTFGGVEIREYPIIAGDSPAGFKGPPLAIGWTPVSTVRFPNVEKYESVRSRHRRTAKDLTIPASQRMVILTNQGFARSEIQKCTKDANLARRQRKETMATLKYQATFEKIESVKRKTLNVVTFGQRNKAQKEYLEKYVPNYGVAPTPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDX0</accession>
    <name>A0AAD2FDX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="100" mass="10604" checksum="027DB9AC4A6850BF" modified="2024-05-29" version="1">MSFASAAAIRKSLQKPSTILVDVRTGLEAMISGKIEVEGHKTYQSSFVSSIAKEWDRDTDIIVYCASGARSAGAKGTLEGMGFKTVLNGGGYSDMKSMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEF1</accession>
    <name>A0AAD2FEF1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="290" mass="32038" checksum="F77A4386F1D49426" modified="2024-05-29" version="1">MATTAINTSANPLKAAWTWGAGTVVESEEEDHDSRWESARSTASDMQASWGWEPSHEDESQQVPNATSKVKEDEEDDWNLFEHRKGVEDDAESGTAATFMGDSISCVSSIQELKVAVRDGSLDNALEEARRSFELCQSLRFSQLVSGLPEEDEENDDKKKANDISSSNFISLANIDASDNKPLVGSSWWNLLPSPSEVDESIRSTGSAKRNKKMKDARRAKVLSSISLSLSLVSSPISESSIPEDIASVKSRRTHNRKSKSKSPKRSTSYKKKDKPDEDSKNQITISHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHP4</accession>
    <name>A0AAD2FHP4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000857">
        <property type="protein sequence ID" value="CAJ1939852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHP4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="100" mass="10992" checksum="45DCA951745F9104" modified="2024-05-29" version="1">MSMQNASCETSNDCPNHGDVLAPSQTKCYGKKGGNGTLDVLYLEESSFHSNVFRPLEDPVVSHEINSQQSCWNVLDAFGLAEQTEQPKQAVHIILLKNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHQ3</accession>
    <name>A0AAD2FHQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="170" mass="19108" checksum="E92B6A497BA10CF2" modified="2024-05-29" version="1">MTSNNCILESFLQLFQCGGAGFTDDYEQDAAVVQQQKHIFLEQARPIGSCSVSSPTSIYSIPSRESMTEIRQDSVNRFGRSRLFSYTSSTPMRFSFEDYHSGEYELEKRDDSIRTNSARTESRQYSPPMKRSNSIATVTTADSNSVGEDLQAHSSEDSPEFQVDVVAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIQ8</accession>
    <name>A0AAD2FIQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS8455</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIQ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042104896" description="ADP,ATP carrier protein" evidence="12">
        <location>
            <begin position="33"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="51"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="153"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="251"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1943467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38392" checksum="754CB374327CFE16" modified="2024-05-29" version="1">MTKNSVLGLPKRILSCLSMMALLMLSTTPVQAEGIAGAAVTKSALSAALKDIDLRYFIAGGTCAAFSHGITTPIDVVKTKIQADPKKYQDKNMLAVTKDIVQTEGAGALLTGLGPTIVGYGVEGAMKFGVYEVSKPILKSLLASLFENSNTNTEPFAFLLSSILAGAIAAVLLCPMESLRIKQVTDESFQNESLLTGLPKLIEQDGFLSLFGGVLAMLAKQVPYTFGKQVSFDVLATFFYQFYGNFLEIVNKWLVSISAAACASLAACLLSQPGDMILTETYSSTKAAKKKKKRRVAEDPASSTKPFGVAVGDIYQRGGSGEFFRGLSTRILHVGMIITSQLVVYDIVKQMLGLPATGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIT4</accession>
    <name>A0AAD2FIT4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIT4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="39575" checksum="CB8BE775B654A4E7" modified="2024-05-29" version="1">MSISNEKASNVPTDAADESTMSSVVGESKKGKPKHRNSASSATVSSITSNDIYSAFGVDRPSSGKVSKLLQPKQRKSVSSITVSSTTSSDIYSAFGIKRSEEEVSDMGIEIDFGNFDPKAAAKKPKKKKKKALKSMEKPTLKGIPDEMPALETIPDENPVVEAAADENLNPGKTTSKVQPTIEAVPENIISNSDSPMVPIGDLQDKDSIEQAAIETSSTSLKILPEPTNSNYFQSSYTAEMEGVLEDVEAQTSSTGQAKQEKCFHEPTRAKKGNRKLKLCLLLFLILVSASAGAAYYRLNKQRAVMITMTKTTAMKEEEVSPTTTVETTRAISLIIGAMTNDRCLFSFGVSIPWSWLSMHRTSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIY5</accession>
    <name>A0AAD2FIY5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12829</name>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8692</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001180">
        <property type="protein sequence ID" value="CAJ1944001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001771">
        <property type="protein sequence ID" value="CAJ1950933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIY5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="33280" checksum="2F42C046D25F69B4" modified="2024-05-29" version="1">MNGYAGLKMTSKMATVQKNKEGFTPRQVKAAMEARSAMHILNAPNTKTLDKIFRRYNKAGFQVKTIKCDWAFIPLTDDVLDDMGVAIGPTAAGDHEPTAEQTNRTLKERVRIALARLPYKVVPKVITECLGRRAAELLNVFPQKDSISSHLSPQQLIDIVNINYNSDMLAELGQYVHAIGTDFNNSMEPQSIKAIYIEPTKGQRTGHRVLNLNTTKMIFQPKVVVLPVTDQVIQHVEAWAATKGVTSINLLWPIWITIKKILIEEPMILGASVLIWKTHKNRQKKRLYLSLKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIY6</accession>
    <name>A0AAD2FIY6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000414">
        <property type="protein sequence ID" value="CAJ1934923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIY6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="16206" checksum="FEA9A40A97AB5154" modified="2024-05-29" version="1">MMYDSVATLFGRIATILNGFNHKNPPPTNLSDLAGVAFQAFTQEIKDVVAEHLETGAAGPLLMDYPSNLSRMHRLRERAEKEEKRIKQLVGIANSAGRIRPNRSYVPGRSAPPRPGGRAFAGFHQPEFQGFQGIQDEGGKCEWLDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJA8</accession>
    <name>A0AAD2FJA8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051049">
        <property type="entry name" value="Dienelactone_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46623:SF6">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46623">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="238" mass="25875" checksum="E78110C71BA893EE" modified="2024-05-29" version="1">MTVHLPPFVSFKPSSGGSDSLPVVIVIQEWWGVNDQCKAHAQKIADLVGAEAIIPDLYKGKLGLEAEEASHLMDNLDFKNAVDEIEVLCAELQKDNADRKIGVVGFCMGGSLALATAALFKKPLAAVAPFYGIPPEALCNVADIVAKTPIQGHFGDLDHFAGFSDKPSVDALEAKLKAAPGDKPFEIHRYEKEGHAFMNHDEFSMAQVKKLGFPGAFAQEDRDLAWSRLSEFLKKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJZ4</accession>
    <name>A0AAD2FJZ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS5286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="9">
        <location>
            <begin position="534"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1936629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="991" mass="108366" checksum="09312C720D9AEDD7" modified="2024-05-29" version="1">MKGYTIGGPLLGDRHQLHENDLVSWKYFEPTISPMIPLEKNKKQRFILLPHQHYISVLAYNTGAIIAYLVPQLENRFEDDDVRIESVCLVKQAKNAKVRMQNILDEMDEDESEDDDAESRQESSEEFIVMAGCSDGTIREFNLANLGALQNSGAVKCGRYHINGPCCYARRVIHVTKKEPIIQIASPATCNHQHGILAYVVSRTKNLEQAELEDTNAVSNVNVAVLRVVIPHFDGTASVSLVSKTADDIQRKKHIDSIKCRVGRDKTNKFLNTTPFRLLAVSREKPNKGTSMDAVFVVLARANTIHIYYEQLHSDKRFSPISLPMSATNPLSSISVAKNNTDIACGHMKGQIKILNDVLNNLESHNLALAETDNLIRPDGTPMASKPTDPRKQLITSKVHWHAHPVTSITYSANSSPVDPILYSGGEESVLVTWQPSRGTDKPVDMLPRLAMGGIVHVVCAHSIDSDPANGILVYCEDNSLQLFESHSKGKKWKLQGLACKKMDEDARCPIIEVDPRGSGSQDAPIVIAGLPEAPGFMQWYDSSKQKLLGSLEVAPFNRVSRTESDESSLPVPSVTSHAFSDNGNDLITLEESMTENEYVGAHDSDGTNNHGIVSTIRFWSWNNASTSTQAQLPYTLRAAMTYPHGPKNRVSALAIAKTGLVACTVSNDEKAFRIWNRAKSERGSAEPASWTCRYKVTIPAGFSNFETMKGGVAFSEDGSVLALSFGGMVTLWESEEARYLTTIRHLDDINNSSIDLVQFVSFGGLHDLLLVKSPSGVSLQSPFPQNASFTGWCWGIPAEAKGISVKDAALAASANCLAVALFDSNKQQSRIVLIDAASGNAGIKTESMHNVKLIGKIDGCIMSLCSTSAEPSAWDNAASTKTLDFFALTSRGTLLKFTDAVSESATTTLVHAAGRTESGGPRLGIERGDLKRERLGYYGLMSDASEKRKTAAEMFGITTLDDGTTVRPLTSDLPTLDDDFVSAFLRRNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL11</accession>
    <name>A0AAD2FL11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL11"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="932" mass="103671" checksum="56E1036584F29715" modified="2024-05-29" version="1">MEKKAIYAKVRVTDDCENTFSDYHDDDSGIELATLPTEESSQIPNEESFQDEPLDEHLWNRWDNPVVISTAISLLCIPVIVSWIVFGVQFTGRLWAVWIGVMHLQWNLRSSHHQVKQRVQRSHDGPSNARSNICSCSCWWSPSIVPCADVLLFGAGYPAIAWVLIELLFRDVDGTINFDWMAMTYRLRVMVGMGSVLVILRLGVGVRSSWDRNFQRKATFGMPFLPTNPSGATELAERRLLPLLKYINLTILLFHLLCLLSLASHFGPWPSSAIPFLPTAKDKDCDPLDTTLCAFPFPSFHHMAQDESTVTGWRVDLKGLAPLRGGIPLHPKFLNRLDGFSTMAPILFYMEGLKEAHEQQRNIEDDFHPRLQGPGHIASSVTNQSITLLLNVDDQTLIHHSAEIDYADSEAPLVLVIPAQPMKHATHYAVAVVNAVGKSGEKLPRTRGMQSLMQEKGGSPRLLRYNEVLFPSLRQAAPWVGDKDNGSDIDSVQLLFDFVTVSEESQLGPIRAVRDGVLQVVQDWDWSDHVELVAEINENECHLASSFTKVARTFHINLDVPSFLQSRSRYAFLDDEAVESGVPVSIGKAKAMIRVPCSVESAALGYEGGKQIRTIMEYGHGLFYNRLEVADGFLSQMAHENGYLLMAMDWRGMSLFDLPVVIKTLIGDPSQFQSVRDNLIQGYAEKLALQHFARNGMLDWLTIDDAKLPTVENKQPTSVFYGISQGGILGGGYLPLSGKTALIDRGILGSPGTPFASILTRSLQFVAYDLLLLLNLYNNREVRLLLSLVQMAWDSTEAAGLMASPINPEESLPPILLQAGLGDVIVSTLSTEAMARSMNSSILPNNPRTAIFGIPVGNPVNMTSFGPKVTLTEVQYKYEYSHLQEDNTLPVDNSVHFCVRWDSALREQVAEFSNTGRIVDPCVADRCMRSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN99</accession>
    <name>A0AAD2FN99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001722">
        <property type="protein sequence ID" value="CAJ1947000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="211"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="393" mass="43202" checksum="AFB3359C8BB11783" modified="2024-05-29" version="1">MPSSDVSERSSRRFFFKGRSKKKKSSKKANASPFQLMQSLGTGSMSPAGAITFVPSPTKLINFKMNFDAPPVKIRGNPKIFSRSDSSFIRVSDLDMDSEHTSCSTVQSEDAHPNFHHPAIDPPPGIETDEKEKWIALNDGDGAWSPIAPLAVSRLAALGLATSIDDCMWNPDRNTDKLLKKSNESDWMQNTFKPCQVSVEDPSHNHEVLVWTGTFSHSYYGSDLPAIRVAGVVDMSPQNLVELLVDSGRVKEYNKLSLGREDLVVFQNDMQEKGPFGCSVTKVMKSVSKPPMIRTNMVFVSVLHARELEDGSGFLIVTRAVHHPENEMGGSANVIKSEILMGVNLIRKINGADNQCLMINVNHIRSPMVPMMIAKKLGVSAAIGFVNDIRAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPL1</accession>
    <name>A0AAD2FPL1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPL1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="320" mass="35130" checksum="7D6742B1EF3B9777" modified="2024-05-29" version="1">MVQMTRKSIKTPERRGISISSLVLLCALLFGTVIFLTANITNDQVGAKRRFTLPWTKQQNKNDKNIFSKLRSALAESKKKKKTNGSKELAEPFDRDSTMTLKEQDYSHIGGPQVIKSEPYPSQFVDTYNAVNIAAPEEESKESADTAVATEKPKDVKKEEKPKDAKPKEKDQKPKGKTPEESKPKETKPKVETVKNAMKETDEATKPPPKTAKHSENKKSKKSATGGTRSSKKSTKSAPAVEGKNLVSSSAAEETKPQKSTKKSTGGSKHSKKTGGSVTKMSGSTENTEEKSKKNDSTGDSNKNRESKKKHTGIANNKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPP8</accession>
    <name>A0AAD2FPP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS11549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPP8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041922333" description="SGNH hydrolase-type esterase domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="435"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1948303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="989" mass="108459" checksum="CD4351EC73400452" modified="2024-05-29" version="1">MRRISFILSLFSWYALIPFTDASSAKGRSTAGIYNLNSCCSNIDDDDGCAHFNNHEELRVAVTDYLNNGCSDKKKCENAVVEKHGWPIGSWCVSRVTRMDFMFQNFRSFNDDISLWDVSSVTDMESMFEGASSFNQDLSSWNVTSVSNMVNMFQEASDFDGDLKLWNTSSVTNMEGMFSDALSFNQDLSSWKTSKVTNMDRMFQFAESFNQDLSRWDVSSVKSMSGMFEGASAFNQDLCRWGTKLPLQVSIDGMFKRSGCLDSNDPILQGSGPFCAVTCTVVVDVDESADADSDSDSGDEDVDSDSSNDADEDNGSIGAPVVDEATPVPTNVHFSNEGDIEGISEHTMDNATIEDTDDNHVHWEDFDMLLNPTTIEEKCFYSKESQRVGAALPCNCADPTKPLAKTGVFADQWKRHHGDMVSVANHSKSNLDVVFLGDSIIEQFSGTAGMGVEALEGRKAAFDRRFSKKAGGRLDGKAFGTAGDVGPNLLWHIQNGLIDNLKPKVWFILIGSNDLFTTRCTEDFVVASIMNVVKLVSEKSPESLVFVHGIFPRLDNPKTENTTVLGEIWRRGQRANNKLRKFCRNDDSFYYLHGGDLMLERSNVTGLLDIDPKMIGDGVHPTHEGYEKWGDFVVEELQQVLADGVETDGDESEVAGVDSIDESESSEDEDSVEDSDKSEVADADTTDENDSSGDEESVEDSDESEVADVDLIDESESSEDEDSVEDSVEDSVEDSDESEVADADTTDENESSDDEDSVEDSDESEGADADTTDENESSDDEDSDKTEIANAGTTDENERSEDEGSEEDSGESQVADAVSSDENESSDDQDSEKTEIVNAGTTDENESSEDEDSDEDSDDEGDADMSSEDKDGGNDRIKEDGDDGGQAGKSEGLEVKTNEIEEVVNKDATKPSSFGNATLWPPDKMVVGFAIVFVLLLLCVYQICRRWCCCQSRSNNQGQYRQVANQNGGTRYKDNSDDDESTGSEGDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQF0</accession>
    <name>A0AAD2FQF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS12011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQF0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002461">
        <property type="entry name" value="Zinc finger matrin-type protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1949273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="307" mass="34653" checksum="8B68CEDF45E7DCAB" modified="2024-05-29" version="1">MSSNLNYKQKVNVERRTWDLDVYEQKAKERETTKGVVGGKTNHNKKPKSSSKLKKEAKVGEKRSLDEVINKGEEEDAVQEEFLPAPKGRAGPELSKRAFLKPRQHRVDVIDSKVGTVEMINPEAAATNKAFGDDGASPSDGVVKTGVGWHCKVCDCFLKDSLAYLDHINGKKHQRNLGYTMRVERSTKEQVTSRLAALAEERKKNSTKLLDDTGEEENFYDIVKAKDEEAKRRKEERARKRKERKLQKQKEKMGEFVEEPKKEETGADNVDTKQEEQETEEYDEGGVDPALAAMMGFSGFAAGNKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTJ5</accession>
    <name>A0AAD2FTJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="167" mass="19285" checksum="CE813877DB5793FF" modified="2024-05-29" version="1">MNISDDSHTHSRRNEAKSTKDFNILNISNHHDKIVPKNMDFRNEFQFEGTADDMKALRGNILEMDSLHLAKKRHVPASDKERLNPAEGDCEEEVDDFEEDSELFEATTTTTIPLKRLSAQGKTKIHTISEEDKTKPTPKHDFRHRIEDSLCVDSIHLNKKRMEEQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTZ4</accession>
    <name>A0AAD2FTZ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1953035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="273"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="428"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="623" mass="71183" checksum="672751EDEB02C88A" modified="2024-05-29" version="1">MTSGTAMSGQTNGNGKMGDTESEATFANGTLVYWKFENGNFWGSVKDFKNGKYVTSWSDGDVHILKEETVRHMVYHAQATLINIPERFEKKTKVQKYFENDGKWWTGKIIGKDRDHNYKIEWSNGAINEWNALDTVAMVQDAKDFDVDESKEQETEHSDEEKEEEEDEETYANAKAEEVENDESERSADSSSNVPEVESVDESVDEVHQSTDASSYLLNDSTEVSSIATATSIGSEDPGDAILPSTFPRTEEGLKEFLSRVDGSADDDGHNQEATFEEEAIFQANLKIEASSTREIPIPTMVPNSLVQWAIRIDETDISFSIRLKRPSKPDQIEDIVEETVVYAKEEETEQEAAEDSNPLTNSVQVDPSERGEFMVDESSSTIILEFDNSYSWFREKTISYHVRIVPPLPHDVSDRAEKSYPYVMKLLRQAQFEVNFSKQAVAAAEQNVGFTEHHFGQMEVDIERKQRKLRQMKQAASKLDERRVGEEQKLLAHRKRLEDKELYISKLEEAMKELEKERDLCWGEKQQIQNSIYDQERQLMRFDDDCKNVESQAEEVKSDLCDLQIEVLLKDNHVADMEEALEKAKADEAEAIENVAFLERAEEALKLRLGERTVEALKMRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU11</accession>
    <name>A0AAD2FU11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU11"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="595" mass="68763" checksum="60C4F459357C4A87" modified="2024-05-29" version="1">MFLMKYLKHAYARERFLLKKSNPQGWICAQTRPAQGLHRVLQLYKNQSFPDFLIIMDDDTYYNMKLFVEHFRKVDSSKSIAIAGCRVRSPTKLINWTFAFGGYGLVVSMGWLKRMDRPIMCPRDDEYCRFIRQKNHIGEREVFKSGMTLADLSYAYALHQPFEQYRNWTTGFCLHSDWLLGYITNFYNVSRHLDAYMGSEINAERQGSRRLCDNLRGNCHGFSHVCHYSTPTEMIAINNIVRRRNPEEFRADTNGCVACEKDGLRHNNPSPTIDFFSFARNTSDFLAQKQVVGSHKSIRHFYKFSALDENDPSCFQSQIDSSEVIKGCKAKSMNSKRNWLLAGLRSPHSRDKHSSPPWLCEQKRLLRGVGEVLNQYRTRHGTIVLPDYLILADSRSYWNFDVFNEMLRNIEIEVKNSLTGAFAASTPLVVGGCTVEKKVFQFLYRVPLLSHGIVLNRGMLDSLTKPMYCNASIVEDPRCFVVEESQLWERETFRQGMSPIDLMRSDVIRRALGICIEAEWVFSFFFQFYASTKSSTLPLQASLAPADSTIRIYLRSVMKRSGPEMLCRYQNVNCNVDAPYCSDVSADQMLTYLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU18</accession>
    <name>A0AAD2FU18_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001819">
        <property type="protein sequence ID" value="CAJ1953132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU18"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="202" mass="23036" checksum="8E78FDA02981D52F" modified="2024-05-29" version="1">MYVEKDKNILTEIIFHLPGADGGEREAKVPLYLGKGSNLEPFCRMYISFKNLCAQWEITGNGAGIANLKFRLFCLHLSGQALNKLNVIETNVTNRTIVQFKNSVDRFITKMSAGANPRNSASRFLKSIACRKSMKTDVSRHIRQLELLCFYHDMLPGTSQKLCENDEFPPNWQNTFHQQKGTIEDPNVTLQMVKTYMQANKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU70</accession>
    <name>A0AAD2FU70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS14202</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU70"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="67"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="167"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="285"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1953602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42533" checksum="9851C1C2C58A9359" modified="2024-05-29" version="1">METKIKFPTGSANERHSDDHDNHNGNSPITVAKSIRRVLTKSSSFPEFPQEPALTNNDHPEDGRGWNHFISTLAAGVGSGALSSTICAPLDLMRTRMQVWGDMSSSFQGEKITPTQVFQEIYQKEGPKGMFRGLGATLVTVPLFWGVYFPLYDQLKYETQQKYPDMNISLVHCGSAVATGAVADLICNPLFVIRTRLQTQALHQLADAHAHHTQPANILEKSGILQTGQQLFRQHGPLIFWRGMSANLIGLSHVAVQFPTYEYLKKWCRDRKASATGHHQAVVQESPLELLVASGVAKMFASLLTYPHEVLRSRMMDSRQATAPTLRGTARHIYSQEGFAGFYRGLPVTLIRVIPNSCITFLSYELLLRWTKEYLKESSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUH9</accession>
    <name>A0AAD2FUH9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001844">
        <property type="protein sequence ID" value="CAJ1953829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="186" mass="21140" checksum="B4B7CEFA4DE94E69" modified="2024-05-29" version="1">MISRPKVVVLPVTNQVIQRVEAWAAAKGVTSMKFFDKKRDLETYQDGDQIAGVDDTEQGYLEEAFDQDYEPEDEDERDFNLHGQFDDINDSEREELLADADNGVDDMPELTVRFQGDDDYESDDNSSDEGNKEEEPIVANLDHHQENVDRGTDDIGSLVTDLEDLQEPPEEEIVFEPEEPQVAKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUI9</accession>
    <name>A0AAD2FUI9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001838">
        <property type="protein sequence ID" value="CAJ1953775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUI9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="409" mass="46247" checksum="3AF2BB0B63B6418C" modified="2024-05-29" version="1">MSILFHALLGTTNVKLQADWHYASENEDLPDLATEEDQDMQFIQSPRREKNPFGLYNHVIMDSGCTNTTICNGELMHGLRHAEKELDMQSNVGSRFLDKEGFLGRFPPPVYHDEDGIANVLAMREMIAAGYRITMDTDADNAFIVHRDGNRKMQFVNRMDVQNGDAGLEMTSKMATVRKNKEGFTPRQVKAAMEARNAMHILNAPSTKSLKYAIRSGLIKNCPITEEAINHAEAILGPDTSTLKGKSTRPTPKKTCDDFFSPPEELYQHNRSITVCIDHMEIENAKFLTCIDTTVHYRSCIPVQIWITPKEKSSWQVQTMMSMICQNSLSDTVEMMTMNQMRTIRVMKAMKRKNLENVDRGTDDIGNLVTDLKDLQEPPEEEIVFEPEEPQVAKVTRSGQTYAQAAMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV96</accession>
    <name>A0AAD2FV96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="164"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="347" mass="37935" checksum="67E4C4FF5052616A" modified="2024-05-29" version="1">MPGHEDSGDPPLGGPDDEPISSSRPRRSRSRSPPRRRRRSRSRSLSRSRSRSPESRRRRSPPRRYRGRSRSRSFSPGRSRSRSPPHGGRHSRERDRSGGRRGGPGFGGRGDYGRGYGPPRGPYGEPFHDAAGSGPYGPPRGGGGGPPPRRGGERRRREEGPPGVSLLVRNVSPDATTADLQRAFGKIGEVRDVYIPRDYHSQQPKGFAFIEYADPEMAKEARDEMDRFRIKGRELEVVFAQERRKTPGEMKVRGGAPGERERGGGGGGGAPSGRGRGGGGGGDRGRGGRNFERSSSFERHQNQQRNRDRKGSDNEGRRSESSPKNDRKGEESGNAAGEGNQGSNNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVF3</accession>
    <name>A0AAD2FVF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS14802</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="95"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1954207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="351" mass="38729" checksum="FAEFB00FCEE1E105" modified="2024-05-29" version="1">MEDESSTISEQAALVPQQDVHPSDHHQASSEAPLLNNNNNNNNNNAEDMAEAGLSTISTAAAAATTPPPVTTPRSLEMDEWNRTIQSLQRASLIAAHALIIVLLVLMAKWVSQLGGLPSSLRETGNAKLVFNWHPLLMILAFCFMTISSLSFRYHRYFGHYYWHQQQQQQQRTTVKLLHGIGWAVATVCMTVGLVAVFFSHNDRASGFIANLYSLHSWVGIAVLLLYLVQFLVGVGTFTPLLLSGGIFGNATISAASKAKILQIHAFFGPILYISMMLTILLGIQEKEGFIGCGYKVVDNKPDMVPFQHFSKIPAVCKQSHAVGFCILAMGLCTMFTLHQMDKPKYRQHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVK5</accession>
    <name>A0AAD2FVK5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVK5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="131" mass="14334" checksum="79599FCFFA1A0E28" modified="2024-05-29" version="1">MNSSPTGNNCQVENVSAPNRYIEEGNASPIDDSIAVLVDQRRVPSPNPTVLDDNIADNASRGFPGPYYLLPEESGPLHFHSREQAQQENLITILDQVLAVLETDDFLVDAGESEYYPSEPGSSLTTNEPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWE6</accession>
    <name>A0AAD2FWE6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWE6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042040461" description="Mediator of RNA polymerase II transcription subunit 7" evidence="3">
        <location>
            <begin position="26"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28901" checksum="EF28419E71472F3D" modified="2024-05-29" version="1">MRQTTASTVINFTLLALQLVSPALSFSTAPRVVIGTIGPQKEVRAITSPKRRSQLCMLDECFGAVTGSFLMAGSEMLDATAAAMDGTEMMTPEYAALDSDPAISLALGVMFVTFLISISLGAEQEETKAGLLEDEKAVTAAPANKFENISKIEMASKDSVTNQKAPIAVSASKSTSNSSQQMDRDIPLEVGAILKAYKEADDDLFLRALSLLVGRIKSTNSELNETKRLFRAVKEEKRKMEDQYELRKYQLEKAEEKLKQMRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX14</accession>
    <name>A0AAD2FX14_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="446" mass="50200" checksum="58783EAC486A2351" modified="2024-05-29" version="1">MECAAAFISVALADFFILGGKDEGRETKLSVDVNASKSVPSDVNWSPVTATTMDDEMSILSDDEEDHFVSPKQSKVILMGEFIDNRSNRLHSDTSYKPEFDAARSVVATSNKITAINFQPPLKFQSDEISSVRRKTKKLSSKLRKQLKTSKTDCVNEYHGDKGERNSTRVHIQEAKGQKRLSRMGMPYTIPNKTLSSSSRSKEWQEKQYAGSMRFASAAIRDSKHNFSTRVLRTKTSTGELQAKFSRNTQNDFRSILSFWESMANHSPQRTGDSQGERARGNASRGKAPPTAAIKAKTNQHKSLETTSATYIQCCFRQYLRRRLERFAAIRIQKQARVFFAINEVSRIREAERESRSRGVALNGKKKIHAFVKHFSGASYGCPVVKDAITRTIPLATEKMSLFASNPATNEATRSSCRTIGGTNAITNGIRQEDFWRTQRVMLQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYW6</accession>
    <name>A0AAD2FYW6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYW6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="13602" checksum="7BD5077A793D6362" modified="2024-05-29" version="1">MVVPAIKPGEVVHCSSEEDYFEILQLAGDKLVVVDCFAEWCPPCKAIAPVFEAFARQHPQVVFLKVDVDHVPTIKSILSVWAMPTFAFVKHGSKVGSFVGAKESMLKYGIENDGNVGICSSCAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZY4</accession>
    <name>A0AAD2FZY4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZY4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042034158" description="SET domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="233"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1958726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="546" mass="61725" checksum="0B084D3045482D37" modified="2024-05-29" version="1">MMRCMRMQFPFQLFLLLSFLTTSIASNENNEVVSETCADENASDGESSVQSSSTPSSLLVPDACGIVLAHVSENDWRVYSLMDRKRSSPIVPYGDVVQQLADMDIDATSLSGRTWNGQETGGQYEGYDKVDSLVPGIAMMARNVNSKKPNLLPFVPRVDEAGLTRQQSPGAGSITHYHNYTLFFTRDIGAGEELIMPNRATGDKSVRDQEVTEEDADENPTLFDLIQTGYCLDNIKPKKSRIKDAGRGAFATRDFEEGTIVAPVPVLPISRAALEFEASDGSPTYQLLLNYCFGSKDDPSTLFYPFGPWINLINHYPKTNVKLQWRNQKVPSASKDSVDMMMMMTMELVATKDIKAGEELFLDYGSSWEEAWHQHRQNWEPVTDHYSPGYVVDDTIRLLRTESEQKDHPYPPNIDTSCFYRYSDRTGEEKASIKKDSSDKVQTFQWKATKGLYDPKFLRPCKVLQRKETAKGRSGYAVRMFNRPGLDEAERIPKGEMHLVTHIPRNAIRITDKPGTTDQHLPGAFRHEINLPDDVFTTEFMKEFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G022</accession>
    <name>A0AAD2G022_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001978">
        <property type="protein sequence ID" value="CAJ1958411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G022"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="535" mass="59981" checksum="CC29B2D81CE83E59" modified="2024-05-29" version="1">MTGPSTGRDATAGTTAKKKRKPRETVVPPQMSTRSKSKQKTQINQSPGATLVDWYKMRNAHQPDAEKFVSKLKSKYFTIEGNDSYLNWQVFGGFAGACFNAPPSNVCFLNGLLDQGPNKIGPAANGLLDEEQKKISPVEKGAPAATIMREDGAPLDYWKPSSPTRRRRDIDNGEQSWAQQLRMKRELQPFMAGKESEEVGENFNEFLTGLDKMLQPKAHKESKKQFKARTEKARTSYQKKLKEHYGDVDHNASELLKKYNIEEPNAHKSKPGEIWKIRYEPRNAEKSLPTFTIFLGSQKKNKSSISNVTVGYVKYYLGSGFVDRCIAYGERCSERGLNQPAFFVPLGDSNTDVAPDHCLVQFKDNGDRLKTLPYVQGANDCCLGFSFANALHHLNFQTEGYGLYQQSHDLSGFDAITQLKWLSHWVRRSVRGVNPSSVQKCKDNCDGMVGVANCIKFLQQQELVVFVPKAKDGTNTHAVTFFNGLIFDSTQKYAMKLSPDALDFIAGTCGFAGIWRSRLFTFTNELKKGQLKIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0E7</accession>
    <name>A0AAD2G0E7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate-semialdehyde dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD(+)-dependent succinic semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS17367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0E7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000063">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="47"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1958820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="516" mass="54533" checksum="1D9A0FF13A1D18B3" modified="2024-05-29" version="1">MVLRTASRLVVSFAITSRNARSLTTGSTVVSRLNDSSLLDWNKESSSSLTSFPVFDPASPGTVLAEVQSVDAAEAIEKSKDALASWRDDTTASFRSTCLSEWSRLVKSNSEDLAIIMTLESGKPLAESKGEVNYAATFLDYYAAEAIRPTGAGGGFMVPSPFATPSGGPKGNVLAVQQAVGVCALIAPWNFPMAMITRKAGPALAAGCTAIVKPSELTPLSAIALDNLAKQAGIPSDVFQVVTVSTEETPSVGELLATSPHIQKLSFTGSTRVGKLLMKQSSETVKRLSLELGGNAPFVVFEDADIDQAVTAAMASKFRNAGQTCVCADRFLVHSSVHDIFVEKLVEKTKAIKVGAGIEADTTMGPLITLQAADSVLEKVRAAIEEGATCELGGNRLDGQFFEPTILTHVSTESDIWKTESFGPVVPVVKFETEEEALTIANDSSVGLASYFCTENLSRVFRFSNSLEAGLVGVNEGIISSCVAPFGGVKESGLGREGSHLGLAEYLETKYVFINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0L3</accession>
    <name>A0AAD2G0L3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS17663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0L3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050118">
        <property type="entry name" value="Pur/Pyrimidine_PRTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43864">
        <property type="entry name" value="HYPOXANTHINE/GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43864:SF1">
        <property type="entry name" value="XANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="6">
        <location>
            <begin position="515"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1959242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="674" mass="74218" checksum="ACE45C65E979574E" modified="2024-05-29" version="1">MERQRLTNLAGQNQDPYIAAAMSASSPSIPQGDMMGPSSVDALNAPPAAPSRTANSGASTFSPNSGAASGGGFGGLGGYGNGGTSGEDLAALEPRSKPASLEEQKAADATLSEYELFQVDDNWLDKTLQERMMSFEAEREEDELSIDEETELLLDQLEALPDDYGDNRDDRFGADDNNGEPWDMYGMDESEKSEIVGGRKIPIPEPGSEFYLDLDEPADPEEQARLDAEFWDRMKDCQLSSRRLERARRSDRAKAFFSRDPNRSQGFDRLWVTAFDNGVFRNIVGLMREYGVEFADNFGDFESTRPEDGLYTVEDVASFKARKVYEVTGLPTVSCHTSFEIEPVPPTSPIPKTKGSVTVPTNTPPPRSSNPRVLSGYRICDIGMHVDYICDAMRPVSEPTRVTRFSSCVCYYDGEMEIFEHAVCDVDLHFSNSLRTDIPLSKAIHDMTDMLKLTHGLEYQKYLRQHMDDVLGGSLGPASVKLRDRVLRDGKVLPNKIIDVSAFMDSQVDVNLMDDCAKELSTRFMDCKPTKILTVATTGLVIALPMAKYLQVPVVYARKERNVVMADTYKATYSSKTVGINRELLVSTSHIDPGDRILVVDDFLSSGATQEALLTIISDAGATAVGVGVLLEKAYLSGRQSLSGYNIPIHSLCRVASVEQQSIQLVEEEGYESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0L8</accession>
    <name>A0AAD2G0L8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0L8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="561" mass="63766" checksum="8EF3995E11F4731B" modified="2024-05-29" version="1">MPDPLEYDDKFEFLFQSEVLTYLSLKDDIQPGVRIVSKSWRLACEAYKTAWIEALDAKHSVVVLELMSAKGKMLNSNTAKITGKRDAKSHRYPILVNNWLTGESDILTIKICNLNPTATHRADPEADAPDLLQYSRNAKLRRSHGMMLDQMLMLARYETNTINGNLVPGEFRDFINLPRGHPALAQLNANMWTYWTVPPKLAGLYGRGTVSDLVSMALMNNDPSLVMAKEDKLWPQDGEKGVHLVRNMVRFMRTWSDQRVYGTFWVSHKFKTGSIMTEYRDGNFGQVYLVKGHNSVIAELGPQLPFCCRTTLLPMYDLWTYAGIITAMSVRPSAKQLKDLEAHVKKAILEKTVSWRSPNAEHWRYPPPPFPTNKNTSGEEADLDWSNHEDVYSNPNINTEESEEVTEEHMEIGRRIVKAALSKGGINPDPSPENRWVIRRWGYSYEENPNGMAMFMGGGGPLPVSPVMFEVDHERGKDPNDKYIPTYTLRDILHGVLDAATRWRLPGVIQPDDLGVVRPLEKVLKECFEEEDVNAISVQWYPPPSEEESDYATAFGNDNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G210</accession>
    <name>A0AAD2G210_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G210"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="141" mass="15547" checksum="3ACACA011DFF549F" modified="2024-05-29" version="1">MVQAAKINSGRSVVVESSTSSSVSSVSTNHRILEGDDDGDAGDEEEEEVNDNQSNQSNQSNQNNQSNQSNQSKQAVPQDPNTPIHDKDNHQPILFNRKQLVLFAGPHNSASTSVEEFMAQWAESGWKRGHPHTKACVRIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4P8</accession>
    <name>A0AAD2G4P8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4P8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1962857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="324" mass="36970" checksum="A6C55A2BE3C929E7" modified="2024-05-29" version="1">MPAEQQFGTESEGIALLKSRLGGFETEGGRQKGLDYQPRANDVAITTTPKAGTTWLQQICHQIRSASNGGDMSFSEISEVVPWLELAADQGQDLEAAQYGDKADLPRFFKTHAWADHCPNFPKTIVVLRNPDDVLLSFYNFFEDWFFEKGSISLDSFAEEFWLSRGVPETKMQNASYFIHLLSWYRRKDDPSVLILFFEDLLDDLEGQITRVARFVSNKKHNFDTPETIRQVVESSTYAFMKKNESHFDEKLSKLARNEACGLPKDAGMKKSKIVNGKKGEGKLQLSQRLRDAIQAKWKEVVQQETGCENYEALRQEFKARNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4U6</accession>
    <name>A0AAD2G4U6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="6 7">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS19667</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6 7"/>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4U6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="76"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1962397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="679" mass="74345" checksum="CB6B653BB7EFDADF" modified="2024-05-29" version="1">MPKKQWSTVVANTSTKDRGDIRRTGDPTSHPELGYQGVQTLYEAFRRGQTLNPLGPCLGFRAVSKSSGMATPFIYSSYTEVLSRIDCFAAGLETLKLVPPTDDNLTLVGLYMRNCMEWFIAEHAIFCVGGATVPFYDTLGPESVSFILKQTGTKTVVSTRDELERLCTVKKSGECPHFEYVVLVDGVIPQADAMAREAGLQVMSFAKVEAIGAQTIATTGHKHSPPSGKDVFTFCYTSGTTGNPKGAILTHENIVSAMAGAMNASLSLSIADRHLSYLPLAHIFERIIQCQVYINGASIAFYRGDPLLLIDDMQACRPTVMPAAPRVLNKIYDKIQIGINAAGGLKKKLFDAAVASKTHNLLESGELKHPLYDALIFNKIKKGLGLDCLRLMVSGSAPLSKTVMIFYRILLGIPVLEGYGQTEGAACATICDPEDMQSAGHVGAPNPACEIVLADVPEMGYLHTDTSHKGQPCQGRGEIWVRGPVVFKEYYKEPEKTRETVDEEGWLHSGDIGLWTVEGQLQIIDRKKNIFKLSQGEYVAPEKIENVVIQSLLVAQAFVYGDSLQSALVAIIVPDEEPLRSLLASDDSLSTLAKASFAEICKSPQVNKLIMNEISQEAKKNGLNGIETPRAIHLDTELFSVENGLLTPTFKLKRQQARDKYEKQIEEMYAAMPKPRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G592</accession>
    <name>A0AAD2G592_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G592"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="417" mass="47311" checksum="78C84DC1984B92A7" modified="2024-05-29" version="1">MKRRMSSRAATTKARIFMACCTSIMVLVSSIYSMTFVFTKSIVKEMILDRKDINLDLNLRSSSKNLILDFDMPTGLELADRDEDDPLITHSSSNLRKALEKSKNLRKAEERTNENPADKKSKDKSQKNKDKLKLGNKKKEQVWIEESNDIGEINSSGDIMNDTTVIVTTNWMPSLPSTDQLDKVIDSLSRVHGLPQDAPMIIAVDGAYENGARYESPMNVDNRAYVKAIKAKYDKPHVTIMAADTKIMLTGNMKRALRKVHTQYVLVLQHDLPFINEVNHTALVDTMETHPEVRLVRFPTARVLTRARDGGVCDEDEVDFESENGIQLTKTHVWSDRNHLTRKSYYAEMFQLPGWSGVRNMEFHMESFGKKDCKHWGTYLFGPRGGHPTIFHLDGRGGGKHMTSTKRVFGNLSGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5P3</accession>
    <name>A0AAD2G5P3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS20314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5P3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13704">
        <property type="entry name" value="Glyco_tranf_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1963763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41526" checksum="EF77E07E1CCBE8ED" modified="2024-05-29" version="1">MRSKRSTTTNEDETRANEMASPTASAASAATSASHYQVPSLTSTLGLFSVVVLVCSFRIFDKRMILPYANAIQNTDMDLENAYGHSAALCAIQKDGLRYIDEWVIYNLAIGFETIYLYDNSEHNELAPWHDQLPQSTKERVVIRHFPSFRAQRPAYTLCWEDIRNRKAHSWIAFFDLDEFLVIKDRTKYPQLMDLLDSLSLEYGGLAVNWVMFGFNGQTTYEPKPVTLRFQKRDANATNPLVKTIVRAQITPNVRSAHFVKYNASETMRTRDTNGKIVGGARNEDLPNDVAALYHIHTYSFGEFKERCGRGDVAKKKSEWNMVLACKPNQTILEEINYNETVYDPACWELLKERAPEYVAKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5U8</accession>
    <name>A0AAD2G5U8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002173">
        <property type="protein sequence ID" value="CAJ1964156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5U8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="226" mass="26434" checksum="5B9297C4DF161F3A" modified="2024-05-29" version="1">MYTMKGHARSQRPTLDDAHKGNISAFMNSLYANTQQPEAEAKVAQHSQDQQVVEQLVEQLVEQPPPEFVEQNDSMPIFPNLDTLDDEELVDEDLNTEKATERTIMRRYLEAIQKRLIHELSDKFPITGETWLLDILKSNDWWIPQHKYSFICKKLAIQFEKEEKEAAYFRKVYVWLPDVRWGPTCMRACGNCGSNKSVGNNGFRNNHFGRRAVALDHDYYCVSRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6E8</accession>
    <name>A0AAD2G6E8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS20436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050994">
        <property type="entry name" value="At_inactive_RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF58">
        <property type="entry name" value="RECEPTOR PROTEIN KINASE-LIKE PROTEIN ZAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1082"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="859"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="943"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="962"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="980"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1132"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1964028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1489" mass="164472" checksum="1677860B5D9F0F1D" modified="2024-05-29" version="1">MDQKEPAEQSLTENKDATTLDESAGDEPPVELPVPQVDQLNKEAVNMVVDVESPAEQVPTNNDKDSTKGNATDEHEMESNESTSKEQSEGRAPVFEKKSASCGTPIKLVFGMVLLALCAGAVLNFFFFDTTDTVLKTSRFNATDPANSSGPNPTIITSSPTTTSPPTRTPSKSPTMIPTISGVPTVSISPTMRPSSQPSNRPTLSASPSSKPSSGPSSRPTMSESPTKGPTSQPSARPTIRPSEVPSKSPTERPSKRPTVSNAPSNVPSNRPSTRPTVSDAPSEMPTTQPSNRPTMTPSDRPTVSQSPTKSPTESPTRIPTVSPTNPPTRRPTETFKMKLQSYLEDDIGILVESNKANQAITQIAEEADENESLTPKLVQRYAMINMELALFDSSAGGNLGRFKQDECSWTGVKCNGNREVVDIRLLGKGMQGSIPSEIGLLQALTQLNLASNNLQGKLPEELYNCLSLEKLFLYQNRLTGTISDKIIKLWSLTDFNLSSNRISGRIPSTMRSGGRGIYKIRTFNVYDNQMTGSFPAEGSRLRQMFYLDLGRNKFSGTIPRSVFATEFVRLRYLYIDHNQFTGTLPSDLMSAGDNRLKALAVNDNRFRGALPGNHMFINELMQITAQNNQFTSMDDQTSTMDPELAAAFKRRREQVQVHQVHNERKTILPVKKTSPTSTAVKEGKNPTFNDGKETERSAKKAEKQEKRRSSRSQNRQSEEKSDAGRKASTNKVQPKSEATVTKDKQQAEEHAPISQKRKSESSNVKEQSRRKSKREQPKKSDGEKATTSLLQPKSEATLLKDTQVDEQGPNIQNRKSKSADDRKKAKRTSKTELPKKSEAAEETNKQSQPILSPQVKSTDVDEKVKQPKKEHCSTPEQTKVKAQTNERKPNSPQLVQSKTVERKVAASSPAKTSVVKAQAQMNERKSNSSQQLQSKTFGEMGAASTLAKTAVTKAKAETNEGKPNSPQHVQSKTVEQKGNRSTPRGQATVMNKNEQTNEQTQRSHSPHLSKKSTTGQEKHIKKTAVKKESPRCQDNRDKKIDHVDIDEEAPRSKSLETDPVDKYYGCEGGNHTKWKRHKKKFCGAVLLVLLVTLVFLIWSLVQFREKYANPERGTNSGGFAPFDPFLDDPIAPSPTSPSTPQPTVVPPIKIYLEDEFGITIESDEAKLAVAQLMEEATANGGNGEILLTPKTVQRFALMNMNLAFANRVSGTSRQSEIEWGQFGQDECEWKGVACNDNQEVTDILLGRQGLAGTIPSEVGLLQALTQMDLSKNNIYGTLPEELYDAVSLEKLFLYKNRLDGTISDKIINLWNLTDFVLHSNRLTGSIPSTMKSNSRGIFGIRYFNVYNNQMTGTIPANLKLRHLYYMDLGRNEFTGTVPSDLETEYVRLRHLNLDHNNFSGNSVPINAGDGRLHSLLLNDNRFTGALPGNHKFNTELNLFEVQNNGFTSMNANTCKLWVFDGGELVNFKSDCTICDCGNKSTMCDQCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6M2</accession>
    <name>A0AAD2G6M2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6M2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="133" mass="14853" checksum="A22DAADDBEDFD9B5" modified="2024-05-29" version="1">MKNKLRMRRRPSMPSSLLPKCVFSQGAIAHGLVPRPKKPEGYNCDLKSSKLSWLSTMTQDSSDLSITGRCYSRRGLQSFASVQFSASLGESLKLEQLVEERNETSNTEGNQNSQQNDYMKWLEGNGLSPAANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7E2</accession>
    <name>A0AAD2G7E2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002208">
        <property type="protein sequence ID" value="CAJ1965623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7E2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="117" mass="12899" checksum="E46EFF6B2DC169A5" modified="2024-05-29" version="1" fragment="single">MVSNDEESSPDGRRSSSRSPRRSKPERDSKAKERSRRGPSSRSTPGAVRSSSTSERNKRRSAEDHNNKSSRRGGRSSRSNSSSLSPKRGEAGRSITHSSSDRKKERRSTRASTPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9K2</accession>
    <name>A0AAD2G9K2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="213"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="261"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="338"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="488"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="565"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="631"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="774"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="917"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1232"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1304"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1392"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1448"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1522"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1593"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1664"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1795"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1894"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1967"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2128"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2327"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2158"/>
            <end position="2176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2177"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2222"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2239"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2257"/>
            <end position="2287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2327"/>
            <end position="2347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2357" mass="265830" checksum="947908B7B912C13E" modified="2024-05-29" version="1">MAQSFHNQTKKIVIPANKEDAYVYKVGSKGLQRDTSKQHEGVWNAEPKGLSQYPLRTSPVKLWIFFYDHLKNTDVLDGILDNNPNQGEFGYSCQNPRKAKPEEMVFFLPKTKVPDSYKPGGIWVHPVFKLENLKDLDEGAAGFMVMGDKVEKTTRLGVGGAWNMMGHNAKVKLPKNEAELGGKQAKEPFGVKIRQSSTGEIFPVPLPSSKTKVDTLKDKIYTKKGIPSEDQRLSFNGTPLEGKMLKDYGIKNGDIIDLEPMKVYVKNPKGKRFLFEVAPDEQVESLMEKVEKEEGTPAEQQKLSFYRRKLDPAKTLADYRIKHMNIIDMTLAPPVKKARVFVEIPEGLNSEGDPNNKIELNVAPTKTFGQIKKLVEEQTGVPASRQRIFFQDKEVPDKKPIAKAKLQDGDTIRMEPIPEAEVDVKMPDGTSRQFVFDPEVPVGEFKEKHKKDFPAGTKLMFNDIEMVDEDPMGKYNLKKGDVLVAEPEDVEVATPTGKVMLSAFTTLTPSDIKDVIEEETGVPKSQQRIFFFDEELVDDDKPIDKEKLKAMGTQGLRMEPVPPEVEITLPSGQSRAFFMDPSDTVQDFKEKHKADFPPGTKLMFNDEELVDEDPLGKYNLKKGDVLLADPDNVEIDTPTGKVMLSAFTTLTPSDIKDVIEEETGVPKTQQRIFFFDEELVDDDKPIDKEKLKSMGTQGLRMEPVPPEVEITLPSGQSRAFFMDPADKVKDFKEKHKADFPPGTRLMFNDEELVDEDPLGKYNLKKGDVLVAEPDDVAIETPRGKVMLSHLPTMTPSDIKDVIEEETGVPKSQQRLFFFDEELVDDDKPIDKEKLRSMGTQGLRMEPVPPEVEITLPNGQSRAFFMDPSDTVQDFKERHKTDFPPGTKLMFNDEELVDEDPLGKYNLKKGDVLLAEPDDVAIETPRGKIMLSHLPTMTPSDIKEVIEEETGVPKSQQRLFFFDEELVDDDKPLDKAKLKSLGTHGLRMEPIPAEVQITMPNGKSRTFVMDPEESVRDFKKKHKKHFPPGTKMTFNGVGLADEEPLGKYNLKRGDVLVAEPEGVAIETPRGKVMLSLHPTMTPSDIKDVIEEETGIPKSQQRLFYLDEELTDDMKPLDKSKLQAVGTDALRMEPVTDDDPTDPKLANTSNPRAFYLTEPEDIEIMLPTGKKVALAVTPTMTVEELKAVVEEKVPEMKKSKQRLFFFDSDGKINNKTPFSKVMFERGSPLEVKPFEITILKQNNGTSFQLYPDPLEYLDDIKDRIEEITGIPPDSQYLSMMGSKLDDMLTLEAQAIEHMSRLTLDTMEILVDIPDGNRIPVAVQHDESIRSITEKLENTTQVPAERQCILSGPDQLQDDDTLDAKGIDGGDILKMELFQVNFLHWLGYEFSIDGLSPNSTLPAMKERIEEDKLILKEDQNFELKGQVLNNEETLRKQGINHKALLVMQEGKKIEVSLPRKKKMTLTIFPTTTMRDMKQIIEEKIPAMKTKKQRLFAFDMEDEIEDDTPLSKLKFDDGHPLELRAMEISVQHWNGKSFDLPCAPSEYIDDVKDMLEDLTGIQASSQRLTHDGKGVDDTLRLEEQGIVDGSTLLLEQMRIVVRLPDGRKIRLRAELKDTIKLIKKKIAKKSSQHHEKQSMLFAGEDLDDKSTLGACNIANGDELTMENFRIDIMDDSDGTIVTLVDVARSDTIDDVRQHIRKQFNRQVEPQQLFSQQSSSALDDSSSLKKLGIAHKSIIVIRTPEEKIAGYKADRLQFNKLFSTKKFDDLDDDIIIPVEPDWRTRTFIFDNDATPIDGFITITVLHWSGKSFSFDKVRPRDTIKDIKLRIRKKKKKKFPPYHLRLNGKILKESGTLLKLGVGHKSIFVMEEKTRKSIDMVPQVDKINIGTLDTLTEDSITVAIKLWNGDLLELAIGATEYLDDIRDEVFNRLSIPAEYQNLSFDGDLVDDTLTLKEQEIVDGSMLVLEQLEIQINLPFKGTMLLKVEPEDTIASIKQKVEKKTAFAAKVQCFLFQGELLDDSSRIMDCDIQHEDELDVELFVLNILQLQGAKFAISGAIHPGSTIYDVQQIIAKKQLIPTHLQQIRLHGKVLNPDLQLSRQGVVHKSILILEASGDKDQQQLKREKIQLQVPAAPIRRRLSNPELESPTFRGRKTVPAKGATKRNSSVDAASANIQSMSKSSAEDSKPDLDDGSKPVLRARKGKRSKSVDRSRDSTPVPEEDARPAMRGRKTDKRKVKRSKSVDPTTADTTDPADADDSKSLKKKKGKRPKSPKRTKSPKRTKSPKRSKSPKRASEKRPSAAASVDSKPDNDEEESKQEAYKLGALAGRVHIDKSTAKSEVEKVKAKEEAKKKEKKSGWWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA87</accession>
    <name>A0AAD2GA87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="285" mass="32943" checksum="714D02F72614BDF8" modified="2024-05-29" version="1">MHFEVINLIRDEKKSNNTSCKYPEMITFFHIFKNGGTTVRNAFMQEQTALPYFAKKLFTGVQFRIGTVKFHTRLNNTVMRLLDGQRQIRRLGEPQMFFGYTFLREPISRFLSGMGQVLHKYNDGILDNGFEMARCFSIGYPTSEMLDCSLAKLMPTVDSEQRLQNYKYLDFHLLPQAFLLRDFTGEQDISIMVMDMAHIPSVLNVLLPHPAAEGGVTEQIPKDRKFWGRKSRSKDYTGGHDLTNPEILTTEQKRMICLLYQMDVMLLAQTKVVPDTPCFELLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAS5</accession>
    <name>A0AAD2GAS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002330">
        <property type="protein sequence ID" value="CAJ1967484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="423" mass="46748" checksum="7291D05C91E4F422" modified="2024-05-29" version="1">MLALCRDGCINFMDLLSYSAAELLELKYDAPILDAQGVDTGQTQLTQLERPHRGTLRALLGYAYLCQNVHRDPITPINCMNIDVQAFFNYQCSGDFIVFNHSSLPQPLVSKPDHCKPIDSSPDILRPTQMETNPDSHLATVRNEFAPKHGELQRPMSDKSDRQATVDVISNQYSDTTSPTTIVSSALQPSIRTSDGVNILNGSRATQLVGAQSTMSRTTLNKHDIANDVIFDSNLEWDQTLLDPNIDRLDKQGKGERPFDRVGILKSSKTILTLNEASDDTLDRLDDFDTAMDLNDTGIGNATLVSNLDWDQPILDPHSGDLGRSVSADSPSHGLLHQLPEASMGSDSDALLPEQDETDEYPMDLENGEQQCVMSDELAVVPATKHLTTIATKNNLVLRQRRNRFYVANVVTTLATKTNLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAZ5</accession>
    <name>A0AAD2GAZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002383">
        <property type="protein sequence ID" value="CAJ1968459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="209" mass="23217" checksum="7CDB8E9A9E650478" modified="2024-05-29" version="1">MNFAIEKKPNDFRPQGMRTIQLFNSEAQANYKKAGRAAMKNAEEDDIIPKGQCGSRKQHQSIDLALSKRLIWDSLILERRSSGWISNDAKSCFDRMVHWVAKTGLRRFGLSVTVTNLMFDILAKAKHGVQTGFGNSDRTFGPTGDVPFQGCGQGNGAGPWMTPMSWSPMTTWSQLAKTSSRRYSRLWTFGQVASVPPVELSTRRSPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBV0</accession>
    <name>A0AAD2GBV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="279"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="407" mass="46289" checksum="350C3DF61C883C38" modified="2024-05-29" version="1">MHHHLKFLSDKYAYNLAESLSKDYVTDRRLRLKFLRATMFDPKEAASRMAVYFRHKLDLFGSEKLAKDITFEDLGKDSMKAISQGMMHQVLPSRDSQGRAVICGSQRLYLDQVDRFKDPVKTLTKAFWYVFMSVADDEETQKKGFVFVSYAADSDHPSDATRRETLKRCAIVGRGLPARATAVHFCSGSSTAAALFGILIKGANAYYRVRLRIHCGSHNEVRYGLMSFGIPINDFPFLERNEVKKTNHLKWIERRKRKEAYLRSRALPKNAVDIPFRVDVILGRGTPFNSHPGNKRLHEIVADHYDEYDRETRAGKTKVAEGIVAMVHEYGGKFMKLDDECGMWIEVSPVDARNKVAHSFRRKREFSVKGSKAVQGATGEDCGRGNKRLRVPNEAGADSIGCCVRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC05</accession>
    <name>A0AAD2GC05_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS23116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002369">
        <property type="protein sequence ID" value="CAJ1968177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1968177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45753" checksum="571D6A678CA2B0B6" modified="2024-05-29" version="1">MDGNEQDSAVDLKEIFERLLAIQTEDLDDDIIVAFTLTRMGITLMEQGNLDEALEKLNRALAIRMEKLGEHNDTSETYAAIGCVFAMQGNFEKAEEMFREALDIKRKLLPNDHYDLITLYQGLTYSLKKQGKYSAATKIYKLQLGAILQMHGEYHPDVVVAYNGIAQLLFLLNRLDDALQLLDRGIEICNHLQQLEGFDIAILETALNNQARALKVQGNLVAATEAFNRVLVIQMETLGEMHPKTAETYEQLGQAYVRQEMVERAIEAYAKAVKIRRKELGNDHRNVKELVFAVEVLELEKNVAALNEQGLAMKAEGDLEKAEQLFQEALELYLGTSNFCTTMAVVLENISDVRVDMGLLEDAIVVSAEALRIRRRMHGDDDADTKRRIKVHRSLLKRLLENRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDJ0</accession>
    <name>A0AAD2GDJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002491">
        <property type="protein sequence ID" value="CAJ1970305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="627" mass="71551" checksum="F2B4DB3CF69D1117" modified="2024-05-29" version="1">MTITDFTVRKKSYRYLTTQASYPNHDSKAVLDAFDPTKDLQLQDLNSLVEKGVQGGAPAWYTGWPKEQVNNFNFWHRPMIRYTTVGEKKEQHFDKLYVLDHDVLENGSDPLAFSWPAKAFSKTDPVKVPKLEAWLINEALEQDHSKLFVMEDITDEDPEMAYDLLVTRKRMPIPKEFLDIAWDGSSAREVLQLVIDRIKILANSEEPEKILEVHEKFRHFVNHWRVANTVIGRDQLSKNVGEPAVLTATSARRWVSGVINSDFAGLDSEDSIGNSPDKTYELLTKTLAAVEESNKTTKTSVESLSEVVVAGIHGQASDKVPPNTVEKKWPTRLSYLKRVAGTTTSVQLPILWHELAKCKKHESIGIVQSLLDDEAEKLNLNLEFIVSARVIKSLVELEFCSRGDVEKGLNVFNSVCFQHYKNANAINDYNKSDYWLTGEKTTASMKDHQAHDKIKHAIFPRDPMQFREMVNSMRVFYLVVFGKTHPLTAVYEKFAKNVDLIARKMGVSQQERALERFLFGIYSRIDHRYFEHLVRSGTNAEENLPDLGTYMETCYHGGSLPESSLFVVAKDPVGPGGTGDKTESQLKREKERAQGHPEKICRFQPKHPLPQEDMYFPWRSACRREQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGF1</accession>
    <name>A0AAD2JGF1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="720" mass="81806" checksum="A3192B8E59C6F7F7" modified="2024-05-29" version="1">MNRNQPAMNQNQNQHQHQPAMMNQNQHQPAMMNQNQHQHQNQLPPEDSTYNEGLGVQLHVNYHRRTRAPTRLVFARLLKAGLAISFLYAALSQAYILKKWAGQNPKAITDDDTPPDFFWKGGEEEEEEDPGGDDNWSRKKQNQDHQQKQKQIKFVFEGITVDGLSPPTVPPAPTQLFPPTSSMGPVEDGRDKSEEESKAESLVTLHPAAPKRPREIAQQQQQQNTNKSNATLHLIPRDQVEFLDKFSDSWLIPKKNLLGINVPTIDYVEQACFQIMIRNDARMTLDWTDFMVEHLSKWWSELKVTVDMDKHMFDHTIHLLQQYIDKQAREIVTTAARTRNGARIPNADTNTRTTRTEEEELPKSPLHPTVAMIAYQTYTSVFQERERLLSPHSLAASLMPLIHVGFGRILIVGYKSDDWKHAWGALELVASKIPGAILENINAINTTTNTTTTTNTTANTAAPNTSTTSFSMKVGHTEIAYVQIPSQSWVKTNAYEINVPKGALFGVQAAIKGNLTKQFHNASAEDWLGTTYDRSYWKYFYLTEPDTILHTKKHLLSLIRDGLDRGIMYMPHRLQPIPHEYNLPPAKKGANQQQDVTKGNKYLSKRYKGRYLPGDIHPFSNITFLDRDDHCCDAGKGWPGRSAEFGEKQIPCGTWWWGCGFDRVVDVRQLNATLIREKHKRLLSYSIMSLNSGTGVIFGPAEQGRRCFPSKEPCSFSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGR0</accession>
    <name>A0AAD2JGR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS11778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001755">
        <property type="protein sequence ID" value="CAJ1948779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002052">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="105"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="282"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1948779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="345" mass="37716" checksum="9C9A3D16065BFD5F" modified="2024-05-29" version="1">MMMQEETANHDDMQQQGDENDAEMEFAQFRTLEVLQEHGIAANDIQKLQTAGYHTVQSIAHATARKLSDVKGISEAKVIKLKEIVKSMVSMDFKTAADALEDRKYLVTLTTGSVEIDKLLEGGVETGSITEVFGEFRTGKTQLCHTLCVTCQMAVTEGGAEGKAIYIDTEGTFRPNRLQAIAERFGLDPAVALENVACARAHNSEHQMELLKVAAAIMAQDRYALLVVDSATALFRTDYTGRGELSERQMQMGQFLRQLTRLAEEFGVAVFITNQVVANPDGMSFAKDSTKPIGGNIIAHASTTRLRLRKGRGENRIMSVFDSPTLPEADAQFAVSAAGICDAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIJ8</accession>
    <name>A0AAD2JIJ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1952723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="170" mass="18729" checksum="DBBAAF9306F94D21" modified="2024-05-29" version="1">MCRRDDIMTSGNLLWEYKAAETARHSMVKINGMALVLAANSTVTSGLTTLYTKIAILADQTLTITSDSELFFGEDHPSVERRKKLVRGKGGLSLLVVRVTTNDASLSNDAAEIGDTSLVQKEMLSTCNPMWKTGPTWITISRLSPCLKRTREASLESTSSRNLLVTRTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIR1</accession>
    <name>A0AAD2JIR1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001848">
        <property type="protein sequence ID" value="CAJ1954019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIR1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="104" mass="11996" checksum="C3A692E62E051820" modified="2024-05-29" version="1">MWESRNAVQYLDDNVQLHDSHCAVNKGVHSQFDMGSTDLPLDTRCMLTCRHSVLCKSLVDKEEWLKLLRLERKANPRSLQAQHHSLWSIFSAPPSERLPTFVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLA6</accession>
    <name>A0AAD2JLA6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS18951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF8">
        <property type="entry name" value="CYSTEINE DESULFURASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="8">
        <location>
            <begin position="90"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1960923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="496" mass="54626" checksum="7BDB1846E017496A" modified="2024-05-29" version="1">MRYSVSILLPIALQYASPVLSFTKRSGSMSAPRSKVSQQHMVLKDPQQTEETANWWMEYEFAHADVAQKCRPDFNILSTTTIGEKKTPLVYLDSAATSQKPKQVVDSISQYYEKTNSNVHRGAHTLSRQATTAYENARDSIASFINSNSRNEIIFTRGASEAINLVASSYGRANLKPGDEIVITEMEHHSNIVPWQMIAKESGATLRYAPIDFEKGGMDVDHFISLFNEKTKIVAFQHVSNVMACVNPVKDIVKEVRAKAPEAVILLDACQSVPHMKVDVQDLGVDFLAASGHKMCGPTGIGFLWGKENILNSMPPYMGGGEMIDQVTMEESTYAPAPARFEAGTPPIAQAVGLGASIKYLEDIGMDNVQAYEHEIAAYMHRRMSEVDKVNVLGPPVGEDRAAVCAFYVDGVHPSDLSTFLDMEGVAIRAGHHCCQPLHQAKGISHSARASLYIYNTKEDVDYFIEKLDSTIKFFLGLAKGEGGEDQGDDEFVPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLY7</accession>
    <name>A0AAD2JLY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002130">
        <property type="protein sequence ID" value="CAJ1963096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20560" checksum="6B10CC0B375916A7" modified="2024-05-29" version="1">MNNLKEELPPNQPEPKGIGFVTTAKVDADHASDTTTRHSRTGFFVWVNGALVYWMAKKQTAVESSSFGSEFCAMKLCCEYLRGLRYKLRMMGIPVLGPSFIYGDDKSVLANTSIPDSQLKKKSQSIAYHFIREGAAKDEWRTSYVNTHENDADLLTKQLPYGQKRRKFVNRLIHHVYEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM08</accession>
    <name>A0AAD2JM08_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="236" mass="26975" checksum="D4C58E52438245FA" modified="2024-05-29" version="1">MPSNSNSNSDSDSDSKEMQPDDRVLKRHTYHARSSETKTNNNSNNSNNQQKTNNKNDLFAFSMHGSDPTLEFSEDSLPSPSQNDMYIDHDTSGGDRLVVLAESSLSTLSLDFEQDETTTDHDKNTKAKKKKKKRNSKRLSSDSQERDDIAIEREALQLKSCELESKLEEDYDDDPAAEDQQQANKRTPRSPLSINNDALLVENTILKRRLQRQDEIILEQSNRVVSDNLRRTDRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP17</accession>
    <name>A0AAD2JP17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS23168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002376">
        <property type="protein sequence ID" value="CAJ1968286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="175"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1968286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="347" mass="38466" checksum="0884B0893348389C" modified="2024-05-29" version="1">MNSGNTQFDQSNTPVAAFLRNNAPTQGMGVDMSGQFGNSNIMMNSQPQVNQLNNFNLAELKRLQQLQQQLQATNQAPNPMMQSSANPSALLFQNYLDQKIQSTRFNDSLNPLAGVGGFSGMGSQNPLINSNLFQEQLMINQNVMNGMKSPSGEMALPSPHSIFHRDGSRRMRGGVIEPFPEKLHRLLLEVEAAGRSDIISFVANGRAFAIHMPDKFFKDIVPLYFRQSRLSSFKRQLNLYGFELINTGPARGGYFHELFVKDRPDFCRKMRRVAVKVGAKSSKLSPTKESQGEDAIEKADKILKQLDDEQSSRNDKQDSMEKPLIESGSLHAEPAAVDISPATGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU84</accession>
    <name>A0AAD2PU84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS11750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040001752">
        <property type="protein sequence ID" value="CAJ1948717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF378">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1948717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="311" mass="35270" checksum="983D2D1A8BD4ACB6" modified="2024-05-29" version="1">MTSSSRHNLISGNERMLQKDQGLIFIAVVSSRETLASRVKYVRQSWAAQSYPIIVVRYFVGDGIESKVELAQQAGMQDPSDLVIMSGLADNEYPPVYKNTRMLRYALHTMIQLEKDHIIWDFKYFMKVDDDTFVNTPALMAFLQNEEVLGNTQEPSIWGRRGYGLPEQRQDLRSAGIDRPYCMGGPGYIMTRDVLGRLATGVRGCVQNLRKSEYKGVLWHSDVIIGLCAKRLSGAYCKGNGNRTQGGSEKHNGSFIQITGRYQLSNILMYGDLQQIVALHPFKDGEQMFFLQNSLDRRRSIDTNGAQMKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVS4</accession>
    <name>A0AAD2PVS4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVS4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="882" mass="94259" checksum="6806F8811601CC42" modified="2024-05-29" version="1">MSEVSKTKDPNKDSQSKSKSRRQKKSKGGASSNVSDEKMERQIVVMPELGKKLRLMNVDQNDNGPTSTRHDLPSRRRSQQRSSSRHSAEVPPSVSMTKLESKMERSQRQSGFSSPSADSEGRRRRHSHRNSSPNHGGGTSRRGHRSRRSYKRRSSHDSSALKSTMGSDSGDDTTAELTLSFNSRSIHDLASIAPDSASQESSQDITVDPLPGAFRVSSEGEVSVPCSSADGLFDGDDEDIDIQTNSISAGTFWSTSDTITMSTSYGERSRSGTITAHSRSNNPRTGSRSILRSVSEEHGIMLEAMVARDYGDELKEARQRGREEALEEVIGSRHRTAEIAVAMPSDNGNHDEDEDGGKGNKRNTFCLALICLGILITAVCVSIAMLLLGSKPEVSSQLDENEESNAKVVVVYTPPTQEECEAIATGIILDDQLSLVHKSFYIHYDITLASDEDLAPLFNAMMRHIQENLIPIMAGCGATDFLGTPIALDDGLKNATNAIVNGKVAKESEASCSSDGSSDNCRSYVLLLDLYLNEEKTSSSLIEVIRDSVNGEELAEALGFQFPGVDMEVNVPLIVSTIDATVVPSTSYDLMTAVPTEAPTPHPHKFEPSRFVSRTVSPTMGLPVTSPGTTSSPSMMPISPSLLSFEPTKGNGSTQIVTPSPTDNLSNTVTTRSTRSPTPFPTPLPTPLPTSLPTPSTTLVGSNPTKAPTRHPTRSPTRSPTLSPSMMFRTPTPEISKSPTESPSSSPSLISTPAPTKTPSLAPTNVPSSIPSKLPISAPSVFPSSLPSVFPSKAPTKSPTLAPTTTAGGGTWCCSNSLTTCDVAAGSCNVNQFACEDSCLGTWIQENSCTGLARWSECTNDVTGCCAPAVCTNQGPSYKQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW10</accession>
    <name>A0AAD2PW10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS17241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW10"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="236"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1958568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="356" mass="41980" checksum="5CB99AFEB7DF4506" modified="2024-05-29" version="1">MKNAKTRSGRAFPVSRKPKPIAVRMDHVEFLRRRRSPRKHLDSKEHDRTLKYFFRKDTRRRQRQEMNQEKEPEVVEAEQTDVASPQRRSNRNLHAIRLKGSGTFYRNLRTLFFGKRSDTGYQNIGGNRIQWLRECDNPPVYVIDDFLTPSELEYFDSRVKDLKFERSFVDNMAIDEMRGVDDATNLDDKSKKRQRRTILDTTHRTSRFFAFRKQQDAKIASLERRIAELLGCWVHQIEPLQLVRYLPGEFFNVHHDMGDLMDDDQVKLPKKHVAVKRRVLTMFFYLNTLTEDQGGCTHFPKCKNLRVQPKRGRVVIWSNVTAEGLPDPRTIHAGEPVNSGEKDFAKYGLNLWICEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX84</accession>
    <name>A0AAD2PX84_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="10667" checksum="F3D737504E4A23EA" modified="2024-05-29" version="1">MTNSFTPCSSSSPLHQRSLGNIRIPSLPDDLLNNSDSPVSQVQGGRLWWIQQGTPQRQERASMSRQQMFERSLFLLDQALEIMEDDTPHGPDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXD7</accession>
    <name>A0AAD2PXD7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="466" mass="52063" checksum="F10BE072BF5DB7D8" modified="2024-05-29" version="1">MNPSDMVTEDGRGRPKLQINLIKSTVICPKEERELLRTANPKAYHQLEKDASGTSADSRNQQIEDIPYAKTASEVHDVIKVENHITEHLTKFGIDWFFVNTVFPIKNRNGEFEQSKLENRAANLLSGYATLTLEEVFDSVVYLYGYGYDESQGENSWMPTDLQWSGTYLKNQCTSDMIDRIEEDLKSAGISKDFWGWGPLIYKVLMDRISASSYHALKALRDSLEEGDGINLYSKVYDGNIRKFCTEIELNLLNQWETEGTQAAAFTADISPPKGKSGSKCFGCGRDSCRQSNATCPRHNLEANPEGKKAKAAFDAAKAAKKASKESGKKGDQVSKGSEKGDKTNKTGKSKWPPAPKGDDPKEQEINGTLHFYHFKDKKWYKCRKQKTTGEDEPSPNTGPSAHLAQSNGVWNGNGLFAGMSGYFSEEFSKVKVGDATNEEVMLQERLLKNAVDRAIRNFNKNLGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2C9W3</accession>
    <name>A0AAD2C9W3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protochlorophyllide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS35</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1889680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2C9W3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1889680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35052" checksum="42F49188F6905A54" modified="2024-05-29" version="1">MVKTKLYPKFVKGLPDVSGKVFVITGTTSGTGNCAAKTVAKLGGEVLLLNRKSERSTKSLAAMKDEYPEGKFVPIECDLQSFESVKNAIAEIKSKYSSIYCLACNAGIMATVDKATVDGYDTQMQTNHLSHFLIVEELMPLLEAGAAAHGDARIVTHSSMGRDLCTTPDKGLEAKYFGKNGGNLGGDSLGMLSGACYDRYFQTKLANSVHMYGLHNKLKESGSKIRAISAHPGGSSTGLDNHLNYGFFWNTALKVVGPLMIQTAEDGAMGLMKGMMDPSAESGVLYGPKNSGTKGPAVPNPPKEYETNAKAIEMLWKTSTEAVAPFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAW3</accession>
    <name>A0AAD2CAW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1909040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAW3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="101"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1909040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="438" mass="49317" checksum="69AC64D8577D273E" modified="2024-05-29" version="1">MMDPDLVEEEEEHHEVQQQPTIAKLPISESDGTSNSNSSSLSNSETWDITRLDRCLEAQKAEAVVSHARDSLFHSRVAEAGDSLDITNFETVVPRFTNSEIQLDNRLARGNFSDIYLIRNFSPSQSFKSCTEQQFYDTETVKKTFRPHEIVVKILRAKLVINPALFASGIADLITEATLLAALDHPHIVAMRGRSIASIDGFTSGKRDSFFILLERLHGTLEDGVARWKERSADTGVMKRGIKGMQTFRLGMLLERIMVMSQLASAMAYLHDRNIIHRDLKQSNVGIDSAGRVKLCDFGLAKVLPVPNHDKEQFLLTANTGSLRYMAPEIGRGEKYNLKADVYSFSILLFEIMNLSIVWQGMNPQQVRQKVHCGSLRPTVSMFWPKSLKQLMKSTWSDAPSARLSMRHVHNELDRVVEELSVELSARNLALIEANNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBM9</accession>
    <name>A0AAD2CBM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS1121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1925063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBM9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042193838" description="Plastid lipid-associated protein/fibrillin conserved domain-containing protein" evidence="4">
        <location>
            <begin position="16"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="5">
        <location>
            <begin position="84"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1925063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="389" mass="42874" checksum="B68A85B55237CBAA" modified="2024-05-29" version="1">MKYLATLFLAKSAIAFQTVVPHPHQRHAAVSPFFLPQNPLLLLQMTMDGGDAPSDMDDSAYDSRQDVLDVARSLKDKFGPLIIDSKAQEKLKSVVKELEKNSEPPIDTKGMIGDWTLLCSTASTNKLMGIDTSNLPFFNAGIVKDIRNTLNKSLVVQQKIKGSPSFSGRGITRVDHVIQYMPPNELSEFSSMLPDALQSLNINPLEVTNQQVVLVHKAEVESTIPFIKTKLALESIVLNIAGKSQYLEPDGADLLGVNVPFGEFLNAGSFETTYLDDELRISRSKVGVVDQLRVFIKVPSTEEVVKEIEEAVETASMEQASDAAVEQLAAMDAPSDVEEENDDKDYDNDFDKNDDDTDDNEPDDKDYDNDFDNDGDDDDSSPSDVESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC19</accession>
    <name>A0AAD2CC19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1918923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CC19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="188"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1918923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="315" mass="33957" checksum="6077723724F9108C" modified="2024-05-29" version="1">MDSSSSKHQLWKDHKEEAISKCIPSLSDQSHKGSSGRVGVLGGSARFTGAPYYAAMASLHVGSDLSFVFCAEEAAIPIKTYSPELMVASVYSAKEFDELATNPDKDAEGPVNQMVQEVTSLMEKMHCLVIGPGLGRCPIVLQATAKIIQEAQARKLPLVLDADALFLLTQEPYHDLLQSTSPVILTPNTMERKRLQGLEESLQHCIVVEKGQYDDVRYQDSTLSCGEVGGTKRSGGLGDILAGTLGTLTAWNSILTSQGVSSEMDLQLACWTACCFVKRATNHAFAQKRRSMTAPDVLSQLGGAVDEMTTPSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC97</accession>
    <name>A0AAD2CC97_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000014">
        <property type="protein sequence ID" value="CAJ1927213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CC97"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1927213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="281" mass="31373" checksum="19DA98F2A1D308BE" modified="2024-05-29" version="1">MSCCSHLCSELKNPLFSVEEPPKGRLDLNAHFHVGQGVKSKVGITKLITFCISIAVLVYAFYKNPEPSFYAAYLTPWGVFFCIWYLGASFCVTACGFADNSTRERATVLVKFAWFFYSVAAVLGCCIAGLYWTAVWTPARGVELNNVMTHGGLLVIVLLQGLFVDRVPLRIKHNLFGTAPIALAYNIWLAIQNLAVKYNPNQDDDDDALYDAVKWRENPTGAIILTIIVLFVAIPFFTMLLWLLSLPGRRYLDDGNDYDDGDDDSKSPDTHNEYDAGDEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDL6</accession>
    <name>A0AAD2CDL6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1930975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDL6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="616" mass="70825" checksum="5DD5E414291A2E11" modified="2024-05-29" version="1">MSSWMTSGKARLNARQNRTFEKRAQQRARVMTAPETNSGSSVPQRILRERQISHPNANANATANTNTNTNTNAYYHPGDPNRGMKRNRNSNIEIISGEQAKAKYSPNNPIRRRGVIATARRIHHAHSLDEHHHWQQLQSQSHSYPPPQNGGEYLHAPPYHPDPHYDQHDHNQQHHHHHRPHRYPPHHQWSGDEHSRSYHHHSRRNHHYPNHNHSRHRMAPYIRTSTGRETMTYDYKTAQWVPLPSSPQPYEPPPSDPIKEAQVYPSAQEPLLEKYQHHPQQYYHQNYIPRPPFENRQPPHYKYHASGGWESSNRSKLDENELSHHHHTHIHPKPPFQDKQLPHYKHPGGASGGWESSNRSKHDEDDYLYYGDQTSVGNHHHLETATSFEMPPDPNENVYLPPPPPPQLAGYETMGGAALAQATITMGHDHKSAWDQDIQPPHLQHDYDRQHDDFQLEESAAANEHDVIPKVQYSKSEMEPWEVADDQQQLQQPPMTTTSRIERSNTWSPGSAAERQSFTLTSSSRGRRISRYSPPKLPYSPPRLPEGLERFQKKRRVFMTPTATSKEEQQVGEEEDEASLSSQAAALGPRLFNNGVQVNEDGTPLVFGPPVDASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE00</accession>
    <name>A0AAD2CE00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1923816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="186" mass="20438" checksum="0FC8850D1FB8F1EA" modified="2024-05-29" version="1">MNSCFTLEPFTIPEHRMTDEYPPPGDLESDSSMSTVAAAFEEEEDSTTMVDSTLMCVFDMPHGISAHSSRYFSASPSIVTPTFKSVSATFRDEPSFEPIPDIAHNNIVAFENPLHPLLEPAPIFQSTEDASSRSVSPSDASSACTSKSAAELDQVCKARIEKLRESLKRSSATRQAVMRQWQALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG22</accession>
    <name>A0AAD2CG22_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Argininosuccinate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1896066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000015">
        <property type="entry name" value="argininosuccinate lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="3">
        <location>
            <begin position="368"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1896066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50695" checksum="3FA7C26C3E9B05F6" modified="2024-05-29" version="1">MSGARGGLFGAGGRFKGGTDPIMEKFNESLSFDKRMWAQDIKGSVAYAKAIGKVGIISQEEANQLVEGLEKVRQEWANGTFEIKAGDEDIHTANERRLTEIVGPVGGKLHTGRSRNDQVATDTRLWTVDAERDILKDMATLLEAGATVAKENIDILMAGYTHLQPAQPIRFSHWLMSHMAPLMRDAQRLKEMIPRANQCPLGSGALAGNAFGVDREFLANELGFDGVTSNSLDSVCDRDFVVEFLMWHALMLTHISQFAEDVIINNLLKGIYIDDAYATGSSLMPQKKNPDALELLRGKAGIALGRAVGMTATLKGLPRAYNKDLQEDKVPLFDSVDTVKDCLAICTGVICTMKPKPEYLMKALSPEMLATDLADYLVRKGVPFRETHHISGACVRLAEDTEVGIDTLTLEQLQAIDKRFEADVKDVWDYEVSVERKCSIGGTGKASVLKQIDDIIAFAKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGC0</accession>
    <name>A0AAD2CGC0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000063">
        <property type="protein sequence ID" value="CAJ1928891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="594" mass="66418" checksum="C905AF480742D8A3" modified="2024-05-29" version="1">MFSQSSWQFSQDASMNQHNGGTSCPPDTQESNLSLDLSLNFGTLSSQTSTPTLTQLSEAYKNPLQSSPQPAAYTISASAVDESDAADACTAAALSILEMSQTTPNTASPQKDEPPPNLIFKTDPLANLWKEQSDLLRCYACPNSLRTATIAKLFFTEEQFGNDAVMLALGTTFLLRSNSPSYFSNFQVGIIFKTNLRCKNGAPLDMHVENSAELDREIDTLSSLASAIGKKDGRKLQLGFANVKRRLTVQLEIVYVLHHLIRGLLRHVLPLAAIKHDDCFWFLSLLMVSCPTENDYDDCFWFLSLLMASCPTENDCYETTLKVAVATQAIQQSPLLEHLRTLWENRSTEPSVAFLQKIHLLFSSLSHNFPTSDLSSSLRDTWGLLERAGLKTTVLVQQFHIVSFGIKHQRGVIVNPVHYFFTTVVAKAVHLSSKHSCTQGQLQGALILFKTYIFERKKERVTIGKEQRHVLAQKRPVQALKSTLSNTHLMLEESLDSALKSILVLPEILPRVSHGQQSTPLPKNLRSLCCLKQVSHKDKNQFFFCLWQNNGDPSTTVVTPAGSDSKIFLESVKRLRKDWLRDDIINYFCSILLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHN9</accession>
    <name>A0AAD2CHN9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS10183</name>
        <name evidence="11" type="ORF">CYCCA115_LOCUS1110</name>
        <name evidence="12" type="ORF">CYCCA115_LOCUS1117</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1925005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHN9"/>
    <dbReference type="SMR" id="A0AAD2CHN9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1924884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1925005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1946042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="136" mass="15312" checksum="F0A32B52D28F1AB4" modified="2024-05-29" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTDLLIRKLPFQRLVREIAQDFKSDLRFQGSAVLALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI79</accession>
    <name>A0AAD2CI79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000213">
        <property type="protein sequence ID" value="CAJ1932195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI79"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="193" mass="21136" checksum="B457E97BB55B417D" modified="2024-05-29" version="1">MSLKPEEEKLVISFRPFQLDDSLPAEGVDKYKFLSNLIPPAALDPMIEELGSKFKPLGVAFTGKGLIGNSAKAHCLMIWASETASQAQQLKLMDALFQIHCSIGKSVGDPEAIVEAAAKAGFTDEDQIRSILKSPIYKDKLKNLRKHAATELGISTVPCLTVVKKDGKQEKLEEAQQIETVQGFTDLIEEYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJA5</accession>
    <name>A0AAD2CJA5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000471">
        <property type="protein sequence ID" value="CAJ1935445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="120" mass="12927" checksum="256A565E153BADB6" modified="2024-05-29" version="1">MGSATVLPGEDVSDIVKHLLKGNPRLGIGLRKENNSVISTIAGNLQYRSDIVFVNQNTRRYRPSVEDRVIAVVEERVAGDGAGGDVYRVNIGGPHPALLSNLSFEGATKRNKPMLASVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJR7</accession>
    <name>A0AAD2CJR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJR7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1936187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="175" mass="20106" checksum="434D143740ED76ED" modified="2024-05-29" version="1">MIWKSILAPVTKRHVQQKTIKTHPLHLFRIIQDVDDYVNFLPLCSYSKILRKAPDGRTFDGKLGIGFGLFSEEYTSRVTVIPETLTIKMKSIESQRINSLKSHWSLEEKQGKNNEVHCGVTFQLEMEVSDPVIVAVLDQVLQEVAGRQVEAFEKRCEELPLPDDLIEVAKRFKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJZ8</accession>
    <name>A0AAD2CJZ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS3746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJZ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1934406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51122" checksum="E274268E04CE9694" modified="2024-05-29" version="1">MERVVSLTLKQEKPKIAIIGAGAAGLCTARVLSRDLGVDPTVFEAKSHGGGVWKYEESSSEKHPMYRGLRTNLPKEVMAFREKPWTGVKNSFVTHKDVAQYLADYEKDFDLKKSIKYSSPVHQLTILDEKDAGSSSFSPETESWPKIRLDYGESGDDQSDVYDAVFVCNGHYAMPSSPAVPGLKEYFDGEVMHSVSYDDPSKFEGKTVLCVGGRASGSDLAREISFHANHVYLSDTTCTLNEDSTPQSQGEVTWVPKTMEVLEDGSVKFDMGCAVTPKVDVIIFCSGYDYKFPFINKESNLNFQCVPGERRVMPLYKQFWHAQFPNLCFVGIPHSVVPFPFFEIQAESAAAQFKSLSLPDPAARAEEAASDSTSGGAKGGRIQDAHFLGSAQWDYCRMMAKIGGIYNDEIEGYIATNKAIYDHNGKARKALFPGGPDSYREIKYNRQGNEWSILQEQVSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLN6</accession>
    <name>A0AAD2CLN6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000719">
        <property type="protein sequence ID" value="CAJ1938439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="117" mass="13138" checksum="662D8E11847504FB" modified="2024-05-29" version="1">MENNNATYEVSIPSLAPLVSWHQEIEAPTAINQGDPIATNDIVSATAQYKMRKWLQSMHPTLSHFKRSHRSKASKACRGMNQHNLTARELDGTMPQDENAWFPATRKSNSSTLVMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMQ5</accession>
    <name>A0AAD2CMQ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methionine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CYCCA115_LOCUS5805</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000002">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000225">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008900">
        <property type="entry name" value="PRK12267.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042005977" description="methionine--tRNA ligase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="18">
        <location>
            <begin position="596"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAJ1937762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="759" mass="84208" checksum="456ED192DD9A3D4C" modified="2024-05-29" version="1">MRCTQIFNQFLVLSCTFGSAKAFSLSSPTKLSKQSNVALGSSAVEAVSNAVLGTPATAFDDGICPFEITTPIYYVNDKPHIGHAYTSTACDVIARFMRLSGREVFFLSGTDEHGQKVEQSAEKKGVDPQDFVDEVSKSFRELLDLMNISNDKFIRTTSQEHKESVQHLWKTLVDKGFIYKGTYSGWYSVRDECFYNESELVDGKAPTGAEVEWVAKEESYFFKLSEFEDKLLELYESSPDFIAPKSRKNEVVSFVKGGLRDLSVSRTSFKWGVPVPGDEDHVMYVWIDALANYMSALGYPDESPEGNFAKYWPASVHIVGKDILRFHTVYWPAFLMAAGLPVPKRIFAHGWWTKDGEKISKSLGNVIDPVDLVEKYGVDPTRFFLMSEVPFGNDGDYSDSSMVYKCNANLSNELGNICQRVCTLAYKNCDNAVPQPGDLTSEDESLLNSAKALREKAAEAIANQAISQYSQAMVTMVKEANKYIDVMAPWKLNKEDPRRMKTVLYVLLEVIRYSAILYQPLIPDSANKILDQITVPKDERTFAHLESSPVQPLTPMQPPVSVFPRFEIPGEANTAGKTEKPKPKKVAQPQVNREIDISQLDIRVGVITKAWAHEEADKLICEEIDIGEESGPRQIASGLRDFYNAEDLEGQRVLVLSNLKSRKLVGFPSHGMVLCASNGEMTEFVEPPADAAIGERISTEGFSGEPASENQVGKKKMLDKIFPDLKTDDDGVATFKGVPLVTSVGPCRAQRGMAGAEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN75</accession>
    <name>A0AAD2CN75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000900">
        <property type="protein sequence ID" value="CAJ1940516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31481" checksum="C2058A4B314C4433" modified="2024-05-29" version="1">MIQRILEMVGLTADQVKTHDSPASSANILDKDPDGKAHDYPWNYRSVVGSLSYLQAMIRPDLTMAVQQCARFCNDPKESHGTAVKRICRYLHSTQHQGLRFKPDPTKGLECYVDADWAGSWQDRTSTDPLSARSRTGYIITYAGCPIIWASKLQTLVALSALSTSLREVIAVMNLVNELRSLGFNLSMDTPKVVCTVFEDNRSCLEIATNHRTRPRTKHLSVRLHHFRSHILAKTIIIKHVSTKEQMADIFTKPLPKDQFIRLRNRFMGWDSLGERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP81</accession>
    <name>A0AAD2CP81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS7546</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001024">
        <property type="protein sequence ID" value="CAJ1941508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF13">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041896739" description="ATP-dependent RNA helicase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="77"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="374"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1941508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="65117" checksum="FFDB7C7EA6FADBAB" modified="2024-05-29" version="1">MDRQRLLLLSLLLSTSSAFLSKSRTSPRNIGYPLFLSDDLSFADLGLSPEVLSCVASQSDWRTPTEPQILAIPKLLEVGTSSEHVIMVEAPTGSGKTATYALPLLESFQRGSQDGRIAALILCPTRELAAQIGSVIKNLANNVASKKQMRKTVMVLHGGIPLQPQIQSLADCARNEETIDFLVATPGRLVDVLTYYQKGAGDSSARDAAFERRVLDALDQQGKQDVTLSKDQLEMLGLNDFQEDDGRAALVNLLSDLKLLVLDEADRLLSRQFEPEFRAVLDLLPKSIPMWMFSATFPKFLEPRMNHIVSEIGAKHVLKIKCSNVDRLPHEQEVSSSLKRKLERSSTSAETETMQKTGSASTISLRAIRLDKKDRTQALLSLLEDHPEWDRVLVFVATRYASEHVSRKLRRGGLFSSELHGKLDQQARERRLNDLKKGKIRVLLATDVASRGLDVSGLPVIFNYDLPRSTADFVHRVGRTGRAGKTGTAVSFVTASSEEHMELIEKRHLNQHIERETLPRFQPDEEKWMVEVEGSRTGLPGVQHSEKGLAHDRMFGGIKGRRKSKKDKLREAAATKESKETKKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPD9</accession>
    <name>A0AAD2CPD9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS6617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000802">
        <property type="protein sequence ID" value="CAJ1939506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPD9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040053">
        <property type="entry name" value="JOSD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291">
        <property type="entry name" value="JOSEPHIN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291:SF0">
        <property type="entry name" value="JOSEPHIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="8">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1939506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="192" mass="21985" checksum="930A0D5A48E16EF0" modified="2024-05-29" version="1">MPNADGLPYHESQALLRQLCLMHALNMLVGEPRLNQAHMDQVCNQLVQLSPEPSVSTTNPHRGRWLGGNYDVNVAIYILENEWNYQVNYYSRRRTPKNNSNSNENMDESVEESSSLSSMEGVLVNVPGTFPWTRHWIMYKPWNRGEGAAKQQWYRLDSKAACPIQVKDLQVQVDKHSQTGDTVLTIQKQQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ95</accession>
    <name>A0AAD2CQ95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ95"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="211" mass="22059" checksum="8A79DD6576DC2831" modified="2024-05-29" version="1">MIGNFFSGVTGQAPSSLNPPMNILENTNIDPQKSSVDLRCIYKASRDGWSALDFHNTCDGRGSGLVVVLTNSGKKFGGYNPVGWQSTDDYCASNAAFLWFEQGGKGVKCPVLPGGNAAVFDFATGGPQFGSSDLIVGPPKAAVMGGFAGPDMEDTSINAGSLKTGSSAFCSAYEDVNGWPRGSHRFVEVEIYCNGNISPSASGGGFSLWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRE6</accession>
    <name>A0AAD2CRE6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRE6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041949715" evidence="1">
        <location>
            <begin position="18"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="194" mass="21840" checksum="3CAF90FEC6971B75" modified="2024-05-29" version="1">MKTTPMMALLTIGVSSAFNASIQRKTTSHFQRNAMKNDENGHDVVPVTSAFRDIDIDIDRVKECTEHFGKCSVKEMRQLKNDLHDKRIQNVVFGESGAPEAIFEEKIFEDELDLQLSLLENEVPKSYLFPEVEEEMDDLPHLKDGTVAASLKKSVEKEKNILLFEELAEEGVLESLAICGFLGLVAFAPQVIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSJ4</accession>
    <name>A0AAD2CSJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="397" mass="42531" checksum="017FFC1EEAA972E9" modified="2024-05-29" version="1">MASMLWAVAECRIVGNSEVTSRELQGNADRQVVYLLNFDIRLALDGAPEDVNIFTLRQIVTSWLDDSYKAKSENDSLLSSGATFDYAALDFVTRRQLQEGAQATNFYKAVFRGFTVWNLESAMTEPVNADFVELIQKATLLEDKRLLDLLRNAEPGMGLGTAVLDVRAELSATNGDNSGGEDESATDKTLEIIIMIAIIVACLAFCLLMFAVIWAWRSDRAKREAYKANRGERDNGNMEKTRGGQHAPTPPPKHQPLGMVPPSTAQTGTPSSAREPPPQEIPGASNYPDSVISDSVITDSVVSNGLDSSYAGYSMPHQAPAGNPAATAPSAKFEPRELSDAHSVSSMDSYGYSLDGYASSLGGPPKFPGGALGGMPTDANDASDADLAPSINGDRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWN9</accession>
    <name>A0AAD2CWN9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS10089</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWN9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF35">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1945947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="210" mass="23602" checksum="F6AE2DAFC639DDD9" modified="2024-05-29" version="1">MSKSPLAPLAPVFQALNWVAFGGWSYVFLQLFKGCDAQDMDPYVKYLEGICLVEVLRIMVGDLKGNLKLGLFLHAIRLGSLFAVIPRLPEGHWTQDYIYFAYSVAEVTRYPMYLFPSSNFIRQIRMVAPLFTFPVGCYTEGLAAYIVLLQEKEEGAEKHPVWLVIVLAFILFVNGVLGPTQAMPALIQKGFFALGISKPPPPKQKEVKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXC8</accession>
    <name>A0AAD2CXC8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXC8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042164400" evidence="1">
        <location>
            <begin position="25"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="259" mass="29453" checksum="AAEF4C00635D56E1" modified="2024-05-29" version="1">MTISMHFWLMTAFLLTALVGVVDGLTLNRRSILLGSASAILPSIHPSLVQEANAIPLPFEKKDRRQLELCLVNVLRVQYWAMKVADILKNAPTDDQKKKAYLEVRLGAKAMVADKKIKIGGGSLLSVITLRGLQIKDCLDDLKYYAKNKKMDQYRDDLIESLASLVEFDGLETTQDPSPRSTLTLGMYNESKNIYVQRMLTERIIPLTDQTVNYFGKDQRIKCEGYVEQFYPRELPAKKIIQEQVKPTEGEEINKQVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXG1</accession>
    <name>A0AAD2CXG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS9240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052941">
        <property type="entry name" value="StomDev_PlantInt_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48004:SF59">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48004">
        <property type="entry name" value="OS01G0149700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1945096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="69331" checksum="A857E3605BE8738E" modified="2024-05-29" version="1">MGSRSSDEDCSHSKFTDEQSLDDIVEIPIGKNTSRPSRGERFGWWLREHKYQLIALSILLTGVIILVATMVAHLGRESNDGPTPPLTKEAIVYGETGSPIFSPTTVSPLTRAPFYSQGQASTDPPVVSPTKRPLTGGPTTNPTSATTQPVHPTMGPTMAPSPMPVLQSIHPQLVEAIGGDIERLLDLSNSPHRMAYEWMMNVDQLRWNENYPTIVQRFVLATFYFASGGGLITSTWEVCSAVPSETLPPDEADALDTRCISHGDEVVCAHSQDFEDCPEYYERFGLNPPWNLKKRWLSGTSECDWYGIECDDRGHVMQMSLSKNNLVGSLIKELSGLEQVQIVNLSDNNLGNLLPAWQGWSQLQYLSLSHNLFEGTIPTEWQQWTNLSTLDLSNNEISGLVILPNNWVELDTLILNSNVGLVVELSEQVGTLRKLETLELQGSLIISDLPSSMKGLTNLKDLNLAHCGLLGTFPTSLGTIENLVELQLQGNSFTGELPDNIWRLRDLEVLRLEGNQVWGRLSKDIGDLAKLKDLRLSNTLLDGYIPGEISKLRALERAHFELSYFTGKVPNELCKLRESTLKELTADCSGSNEMKCHCCTLCCDRADETCSVQTESSRKRALGSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBL0</accession>
    <name>A0AAD2FBL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1894987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBL0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="4">
        <location>
            <begin position="336"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1894987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="499" mass="57687" checksum="7C8BA6F48CC5AF54" modified="2024-05-29" version="1">MPFWKSISKLGFQKGSLVYLYSLSAIIIILSLATTTYLAAQLDDADQRSDHTDRHSFDRPIAIQGQGQLPISDGSITINNYGHDKDDDDDNGNGNDKTPPPDLLLSVPFYVYEELIWTNATINDEPIPHVATHGRHKTRFKHSDDYWFYEAAMKHPMRTTDIYEAKLFFVPIFLNFLDYAKYVKRDFCNLGTCGYDLLLETERKLQKHKAFRKHPERHVIVRSFYTASWERWYNEYESMDKGYRKFMNLIPKMSCIIFEGKEFIPSPPNPARVTLPSYYVGTACNQSQPWEDGTPVVPGAKPFDVAMIATLKEERLAFQDRRNVCNWLNQSTTVKTSLCGPGKRCPALSQSKFGIHAAGDTFGSQRLIDTMLSGSVPIFTSLDQYRIQGPWIDWKQLSYYLPVHDDTAFSGQPVTQFSVRKTPSQEAFLESLQKILDDKEGYERRRQKILEHNPLFDHETMYPFDTYMYLIQAELFPETRQRKSRWSALLLPPPLFDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC05</accession>
    <name>A0AAD2FC05_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1908739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1908739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="100" mass="10566" checksum="C29079701B0422DE" modified="2024-05-29" version="1">MTAKDEAKQLDSVTDRVKDVELDASKAQEAMTALSSANKGDDSKAAALASMSVSKEDVALIVSELEVSEEVAERVLREAALDGAEGDKMLEAALRRLVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCE2</accession>
    <name>A0AAD2FCE2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1913118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCE2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051258">
        <property type="entry name" value="Diverse_Substrate_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42920:SF5">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42920">
        <property type="entry name" value="OS03G0707200 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6824" evidence="8">
        <location>
            <begin position="43"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="493"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1913118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="63462" checksum="6529CBEDFF35A0B4" modified="2024-05-29" version="1">MDMKTTPIKIKIAKKRIRRPRRELPEDLSDLFIADGDRPSDLDVIAGRGGGSNHHEGNKRYWRRILAERPGYKQLGKNDNTSKNEISEGIYMYILSTGGRFLQLDTRTEKWFMIPKKISLDKIKQALRDKYVPHFLKGETIPPMAERLQASSAPTVANTSSHQATAHAAPQSKRKIGLLLAAGAICLAEKGSVCNAYQTNINYGLTVPRRRGIPITKSWISGTTRHVDSMQAWGTFEPAIRLVYKIQPEVPSFVLSLAYYIIATIPLCILAWRETPPDLENVETESEIKSNFSQLWGGLELGTYLFVGNALQVIGLRTVPSDRAAFLLQLTTIFVPLVQSILARNLLLIPAKTWVACCVALAGVALIGVENADGDVSFASFSLDLLQFSAGDQCIMLAAFVYTFHCIRLEKYAKEIPSAIRLAAAKASTETGWSALAVGAGLIAAAQTGTLENPVLGGLQTSGRGILEYTETFLDFLDSMQDVDISQYVTLAGSLSWIGLVTVAYTISAQTYGQSRVPPSTANLIYTLQPIFTALLAYLLLGETLSYTGLAGGTLIGSAVLLVVAEVGNGEPGGVSRSIDSTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDU0</accession>
    <name>A0AAD2FDU0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000138">
        <property type="protein sequence ID" value="CAJ1931321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDU0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="384" mass="42210" checksum="9AB0BD31846CD946" modified="2024-05-29" version="1" fragment="single">MSAAARHTNGQGQFVQQGNTGTCGRPPCPEPCLPPTGHITHYNSPWGHGLTVWRTGIGYCPPPQAFSTAMGQPGNTFALRAPTPRHVATHQGRSDRVLLTGTGRASEPSSSSSPSILHAWQTAAELCTDYYGWVPNEIEVHGDEATLADALLHGCLRVISDGSFKNELGTEAVQILAKHGGCHRIIIRCQTPGLPQDQSPYCSELIGLLAGIMAVDWLLEQWFPKISIGPKVRIACDGLSAIEMAFEERPLSPTDAQFDLVSSIREAILRSSVDWAPQHVYGHLDKSNLFDELSWWEKRNLEVDGMAVEYRKELETANHLIALNPRFFTELAAMYVADTKQSCLDPQFIQECVTLPALRSRWRDKGTISAEAESEIAWDTLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF52</accession>
    <name>A0AAD2FF52_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF52"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="390" mass="41496" checksum="D037FAC1C66773C4" modified="2024-05-29" version="1">MPYGRDKAKTQNVAAQAAFLSSKLNFGPPSKAAPQTPPRSKGVSKDPHFGANRDAIAAKLNFGGKKPPPGPKSPATIPKPSGGKEFQNQKAALAAKLNFRPPLPAGDPLAKPPNALPNRQPGPPIRPAQQVSSQNGTQDFSAHRAAIASQLAFGKSKPSSPPNSNPPPTRRRNDNYGTDFFNQKQALASKLVFRPPLPASPTSGGSQVSPLRPTTGMPRSPESPQETSYTPAPAAPAGHMGLAAQAAAMASGLKSRQPEDAITTTSSGAASPQSSRSMNDPPPEPEMSFAQPEMKFVRSYRIGGGGGGAEEEQPKEGPFTQVIPKQVVAGDENGRIQVVLVSEKFEWGTKPLNKKYRRNRVMVKRLTTNTPEEERKRERNKKGGGRCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFD8</accession>
    <name>A0AAD2FFD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="82"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="29440" checksum="1D13FEE82E37EC8B" modified="2024-05-29" version="1">MADFPIVPAIETRMKAYLDWRRQHELDSIRADKESDDTSAWLFAVQRARDLEDSLSESDKRTTTRKDSVDKWGATTCIESNDIDQVIFFHKNDTNGETICDKNAKRIMHMLPARIDPDLANARTYANIFAVYMDHNMDRDSTEKLTIVIDIRAGTGWGNKPVLKMMGILRAIINTFETNFCERVEKFVVFPVPRIARAIFNAIKRLFDPNTAKKVVLISGPDDIDAPVPREKIEKHIDFEVIDYMELARKSLFKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGZ7</accession>
    <name>A0AAD2FGZ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1930959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGZ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1930959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="119" mass="13691" checksum="4971BAE0911152D4" modified="2024-05-29" version="1">MGGSSNLNMLVVSFCESIKEDPSLSEFFGNFAFKDLSVLEEELLMAALVEPEGENEIQSRRSRVALRHYQLFQSGLNERHFDVLSKHLKFALEESWVSEDVIQDCERHFASLRPIFEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGZ9</accession>
    <name>A0AAD2FGZ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="62"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="62"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1937622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="471" mass="52158" checksum="A38C1CED12C5965B" modified="2024-05-29" version="1">MSSMGEQKMESQANTANTDVASTMMGGVTQQVESSNTDGVQKKKRKPRKPPAVAWKKPKGMPKRPLSAYNLFFKVQREAIMSARANDKSEAALKRSKKETVGIGFANLARTIGDKWQSLDDADKSEYMEQAAKEKARYKQEMVVWRKKQKDEKERQANMPPATVAVAGNFHGGAIPAPQPSSQQSSMVGMMGRSFYDDSRIHPALWQAGAGGLQNRLQHHQTNGLLFGMQQPHQQSPMMHSYLQELADNTLLQRQQQQLQELQTRQLFLAGAFDPSPRPHNPFGDAATASYPETWFELPSAQQHHQHQQQLPPRQPLAVEGESNQQRLAPHNDGELQKLQLLQDQHLQELQGGGHLQGVDLDMLKEQGDLKKLSESAMLLKQSSTEAPPTTLSRGSAAAGGGNDNTQSLHTLASKLDNDTISFLTEFRFNNGNANNGIIINNSGTSGSSQQATTANFEDPRTKHHQMRNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHR3</accession>
    <name>A0AAD2FHR3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHR3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="445" mass="51170" checksum="28068CC54693733B" modified="2024-05-29" version="1">MATTQNRMTMRQEQKPIPGILREVCTQSDWSLRLYRPGLGALLLMLPIIMNETWLMYNFICDTVPFFFREPKEDNFASNLKPEEWRRSHHACLKAMCRLANQIEFDCRVDETGESAYMLVVDDPSQEVPFDSEIPFPVDCVDTLDLMLGPENMEILGNHLRSSDLFDADTIDFIHYHDNNNNDVQSETTDSGAQKKKALFQLLPGQCGIWDILQQSWYEWHGDSNIDPPPPVPLVNFDNTEPGQLVRIKAREYLCYEEYIPKEAKNNPKYWISAYETVLKYRWYISFCAAIISSAFVEIMGLFVIMVRVLPLTICFAKFTTTVDPDPNYKMLRTMMEMWRIWTHLIGIHAMAFAIRGSEQVYVVCALATASMLLYGNTKASMEWTFLHIVSYGMEWEADAVAASNLILPSIEDALDLFIPAPGLCLKAIVVYMLYMSSSRILNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIN9</accession>
    <name>A0AAD2FIN9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIN9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="289"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="363"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="458" mass="51012" checksum="12CF83C178A4E7E2" modified="2024-05-29" version="1">MNFSMTTEPFFNSHQLSKEYPQQLNEAGQHSGAEKSLAQLLNLDYKSNPAVPRALSSNNTNMNTSNLLKPSDPTDYSNYNVNSLFSALAAQQAAQHTAPEAPAGILHQSLLSAPVPSTTPATAAAALDVCQHSSNEIQSLNASLSAPQTATAQDNSFTAFEPSPINENKMNVLQQGVDGAYALELWRQQQQHQIQKLFNMALQPGSAANLPQNSAANLRSLLAGSTRSSGNEAAKRASASILPSALVDPDMFHPAAAKKQRVEATPVAPPMVEDSMNQSGRFRDYQSCQWSIRFHELQLFRKEKGHCCVPHGYPKNIVLARWVKRQRYQYKLRAEGKPSTMTIERINALESIGFIWDSHGACWMERYNELKEYASKHGSCNISSRYIDLHGSQLSSWVKCQRRLYKMYMDNKATNMTAERIAKLESIGFEWELRRSRNSISSKQESQEVPDIQNFGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIV7</accession>
    <name>A0AAD2FIV7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000394">
        <property type="protein sequence ID" value="CAJ1934832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIV7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="183" mass="20703" checksum="D82128F80243DC7B" modified="2024-05-29" version="1">MSTTQTKLLQKVVGKFLFYARILHSDASYLTEAKARSRVDGHFYMGSAQQSSTNLNGPILGLTKIIKAIVSSPAAEAKVGALFYNCKEAISIRTLLTEMDHPQPATPVQVDNSTAVAIVNNRCRQVRSKAIDMRYYWVQDRVKQGQFNIFWAPGPTNLGDYYTKHHPIHHHQTHRPIMLHSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ53</accession>
    <name>A0AAD2FJ53_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ53"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="452" mass="50117" checksum="21AD7C210794BB09" modified="2024-05-29" version="1">MEESAPENNASGIEDETQNPAPSRNLVKSALFALAFWAAIFMMFVGYFAASNLQTRSYYQNQNMDGKKTKRRAKKAYKVSPQSSKLLKHHEALEDLLEAMEDLESSQAAEMEVLKDKMALVQDLQEKIGASVFHSHENVGNGVAPQATHIKKILGTQSISSLSDVETDVGMAIQELEAIIESIAAATDESSHIDLAVLDELLKQEFPERSPSVNNVKCGTKKTTEPKAYVPDDAARKSHLEDMVTILYELLDQRSKEEGKFYPMDGKTLQTSSLQTIRRWLNSKTKSVTSEIVKVAEGTADKDSNADGSCLDEEMVLDLLEGALDGMSQNIDLRNYLRRRAMELDPSAKSIILDADLPEIRPFVPEPKTLQLSRVLDKPILFEVVDWIDKLVEAVGGYNDSVDNYLDSVAGSSRASIGELVMEEVLKKADGVEIPNPKPTIEKVVKRILKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJR3</accession>
    <name>A0AAD2FJR3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000535">
        <property type="protein sequence ID" value="CAJ1935989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJR3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="527" mass="59436" checksum="38C69475CD2ED32D" modified="2024-05-29" version="1">MSLVDSESSAPSIERSSNTSSTSACPFSVEMIADENDDGSANSVHLAIPESSSMKSLRQEEEEDEETGPELVRVDSSENSASSTDDKEGEKPEMATRVSSSSSREVVKKSQEDAGMIDCLSDQFSNMFCPAGESHLCISKKENRMVSCEVPCQAFDPSDPSTDVFSHLQFWWTPSQEEKLQLKKSPKNRSMRKKHRHVKSLMDNWHPKHSEPLVRSKSILDAGHQQQVVPQSPTMDTACYDSDPEEVYKNEERRESMHFGGFKDRKPSPLNTSLGDDRLMSGGHPRAPTNATRKNFHFASTDRSPLTPSHLDLMSPENDEYIREFVQEVTNSRLNLIWHRYNEPEGDCLSDGLRAPMAVSATFEVGTHLDHKVVQPKLTWNASNSNQSPAKKSQLDSNWVELLSIIRVITPNKLNRKLYPFARTDRTLCIVANDNRNPYLVFEAESQEQRDWLVTALKMTVARLASIIIIKDESMLLEFFSPYAALISLREQEEADEEESVEEDVDLVNGDLNLMEMSPVLFNPKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKC4</accession>
    <name>A0AAD2FKC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1156" mass="126158" checksum="42A81816DF4B15A0" modified="2024-05-29" version="1">MTERRRIRLAAVPYEEEEEVEAPGNANPPQKFRRLAFKDEGAYEPSIEDPKQRMAHVSKESTERKSVSKRTRRQSQKKSRKSKKRGPVEPGNLMEELESTTWSLLKCGRKLIEKSIEEGKVQALKAAMRLRQESDRNYRGRGNTKRRTKRSRMRSEFGHGAVDPSSSEESRSIKSGSSYGSHSISSNIASSYSDGQPSMSLSASSSKSSKKKKNGSMSSRAKLNADASFDSLGENSIIADDSYTTEESLPSQDSSTDNVNSDDDRSIVSEAWTAIKDIVETPEADADRLGEKSTPSIAINMEVLLEPDSSDDSWIQSIKSDSNESFSTALNKELSYHRQMPSNMLQQCINEIKDVSTKGHQRKPTVELSDAEFLKVIRETGKQECDVDQTATTDSDTNFLETIEEPKALDQAPTLPSSPSTFSNSDFLKAMQQEHGVHVGTESSLAEPVLSNTDFVKAMQEENGVEEEVKAAPIAEPLLSNADFLKAMRQENGIADEASSGRSVSSAMSTTDFLKAMQRENGVEEEVEATILLSNADFLKTMQQENGVKDETGATSAAPPLLSNVDFLKALQQENGVETETEATVATSTLPSNTDLQQGSGIAEKSIETHDEQLKLSEDLSNADFLEAMRQSLSVTGGKFEEPKTRHSGDVDSISELEGGNSNEEGGFSDSDFLKAIQDTGVEDDDTFNGNNISTPVQTAINENFLSALKQMGGLDLGNTGMFSLGHLETIHEVDSDCSKSAQSSPSRSPPTSFTLIEEVAVVAMNADGSCLGNEITGSTQSDDRLMSKQQARFGHREQTNSTEALVVTEEKSDFGPGNELPDLKCVSSDESDTHCDRLRGILGVDGSESEKEEDIDDGDTGFMTADDILAEDDTNFFSAGAGDDSHFFSMMTENQGTERDSIGSNDSLDEILSFRNGGEQTATMTSQEASSAEAEVHGFDEAKAELETRAENLDQPENRMVEQLETIPGQRYVECRQDESSVPLADELNKEDIEQRKALIRAIEVDESLTPDEKALLVTEIESGVPIDETSSIEIDVDATSSSESQNGDRDAPEHSRMEINKAIGKKVIQGWTLLDSSCRHCALPLMTDSEATEAACIFCDYSRSMNGGHGTKNCSLAFPPPPPPIANKKSKNRRSRMAIKEAPVDPPSSFVVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FME8</accession>
    <name>A0AAD2FME8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS9755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FME8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="3">
        <location>
            <begin position="67"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1945611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21300" checksum="66AE25D42B3029E6" modified="2024-05-29" version="1">MSLSQQELLEKLGADLQKGLTTDEASKRREDDGAFNVVQPPIDCPAWLCIVLPCIKHVPSMKAFAVLKPDDAEIKRNGKWVRYEASSLVRGDVIRLEEGDSVPGDCVTMQVSGSEDLLVDLRSVTGEERLKTVATGSDSMTSLYYGGKVVQGSAIAVITAIGPNTLLAQLIREKRFPPKEPILEAQDETRFNSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMW1</accession>
    <name>A0AAD2FMW1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMW1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="3">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="583" mass="66801" checksum="0F6A62DFF412622D" modified="2024-05-29" version="1">MYFTTIRTRALCEQERRRNQSSTFTEPLPISSPLSTLPAASQTASLKPPSSSPEDELKSFLEEFNQPVVTPEQKAKNEKEMEEHPILKVHFEMLVPKKIVSYEDFWQRYYHRCYDLNRIVSELQQQDKQQEQQGAKDLDSDPIGDKNPKHQQSIPPSQTFKSVQDRIFQMTSSPARQDIEKKEEPNKDDKDTPNLETTFDSSSLSFGSASFNVIPIEAQNSTTQSLTEATSEMSHHDYLPSPWSMERQMQYENHENGDDSSSFGSLVQMPNCLSEVTSVVTNPDQIHRYPESPDYCDHVEEEVVEHSTAEALEQAQISDTASTLDDRLSGASIFLLNDDFYEQNDKLVDMIVAMGGKITLEMMEATHALWIPPPKEAESLIGNDEQKQKQESWEDFRENMILWVAESYKVPILDSDKWLPRIARLEFEEDWSDVNCEDFHPGHTQAKTVTRSSMGKKVVESPKEATMTVAGKQSKTQSTSNNSSTQRQKILSFAKVALLLTMVLLLLTQWHVVFPTKTFTPNLSISKEETTKYKGWPLFRSRQRIPAQSSSIANGQMKTNVQESRWNKILSKIKVRRQRQIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN16</accession>
    <name>A0AAD2FN16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF46">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042175411" description="Phytanoyl-CoA dioxygenase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="41133" checksum="EF6C83E8F8ABE821" modified="2024-05-29" version="1">MWQTAIIVAAAVILEVVQLHQSKAQSQDAIRFRGGAKHPKTPPLPSVTITPTELTEYHRDGFVLKKGLLQGEELSKLMDSAEEIYATANHQKDANLPNFFKKLTFDLWRRKDEFAQLAFENLPSVAAEFLGVGDAYEMINNEDNNNNAHEKEETIRILKDGFFGFQQKNNTGCGFHVDDKIFWPASYETTGVNFWIALSPMRIQEGGGIRVVNQSKVEPIFEECRQAITNVGERGYSPTCDMEEVSPECHEKMLEASVVFDMEPGDALIWDRWTFHRSEPFRPVPEGERSEEHQCDDPSAGADGDDYRLRYTIRYVPGKAKAWGRHHPSQVTGETFDSPYYPQVWPSVLKSEMKSIQKGLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQC0</accession>
    <name>A0AAD2FQC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS12027</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="358"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="587"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1949305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="689" mass="76601" checksum="FB8E565131869840" modified="2024-05-29" version="1">MATICPDCGSKNIDKQDASGQLVCTDCGTLLEENALCSALEFVEGAGGASSMVGQFVSNSSSKAYTAGRNVYAISRDSRETTLARGRQKIQDVASRLRLGNHFIDAAHRYFTIAVEKAFVQGRQTLHVVASCLYIACRQEKSQHMLIDFSDALQVNVYTLGTCFLKFRRLLGLKIPILDPALYVYRFAAHLDLDDKANAVALTALRLVGRMKRDWIVVGRRPAGICAAALLIAARAHGFSRHYQDVTHILKVCGLTVNTRVKEFELTPSAGLTLDQFNKVELSTEADPPVYTRNKMREARAKAIHENNVKLLESGALDDKLKGKRASKWREVLPQGKKFQEKQEEFEKLYHSIEQVMVEQGQQEKPKETFEFDTEDDDDDDDDDDDEEEGEGENDKEGAAKEVGESENDGEQQDDAQKELADGEDGPAPQNELAASEGDNAAASSIVAKLPPSDGEKGDGDDNEKDDPMLKKPPAKTDESSSTALVPAIAAPKVQQQLAKVAPQWRQAYPKDKYGNAMMLPNYATAEELQPSTCFVEGNLDTVTWRESMPQDMVEDVESIFRNPREIAEKEAIFNKINKDYINLQNQKRKHKVTQNQKDNQSDKDMEEQEQKARKYMTRKRRRALHGEETTEDALLEAVANRKISRKINYDAMSAIFDDDGTFDVGGGNATTNANELEAGHNEAVMAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQL1</accession>
    <name>A0AAD2FQL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1303"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1332" mass="147976" checksum="97C429A82AF53A6C" modified="2024-05-29" version="1">MWRSARHYRRLQAVPGRSSLTPLGYASRAQHPISQPSILLPPPSVTSSMLSVSFSSTTSSESAPAAPKRITKSQIMFERTNELLRTSPESITWEMKDWRLAEKYLHALSRQPSHTSDIIRLSFSLLERMVLMAERNPEFRMNTEHLNIIVNKWRIGTRYNVVHRKKYSAPKVLAMIDDFCVRIPTLRPDTKTYAMIMAVQTKLDPSRSPTFCTEILNRMKPGSSAPPNSIALTNLMDAHVRGQGKDFTLSTLAIFDHMVNSSDRTMQPNVKSLTRALESLLTSGWKNEEAVPHMNRVLGDMLSRKGRLPNSQFLSLALSFCLGDEVKQRKSTPQLADALMTVVEEKAKRYPQIAPEGAAYANTINLLAKSDDLSAPERAEYWLQQMLASSKRNKPKVGEPRASLYTSVIAAWERSGLPIAPTRAETIFDEMMENTTSVTPGAYYLLISLWSKSDLPEAPVKAEEKLRQMIAKSKYNPKLVPSLLSFVNVISAWKRSTVDEAPERAHAILDLLLDVKARNSHVELNEIPFNIVINAWASSGSNLAEAKVDEIISRMNAQASSNPGAAPSIVTALSAMKCLSCIGDGPKKTLKLLDMMDSGIRNGNTSNQHLRSRLYEEALKLWQKSTLADAPQQAEQILHRYLAEPNRYQNTKTTKACFEIVLELWQADGSAEASERLESCLKELERRADDLLKSGSNVELYAFLAQSLARSGLPKAATRAESVLDLITERVSYADRRLTEATISHTLDTFAFLGNFERLEIFLSSMGKGLSHGAGSDKIPNTYYSTISALVNINEMHTAHRVLLAMVHGFNESGSSIKPTARCFGPIMKGYADAGEHEKVHDLWTQLNQIQSENSEDPDFFPSTSILAALCKSEPRNAIRDHAILHHLLEQSQVNDDDTPDAELIYSVLDALVQSRDSNAGSSAEMTLLKMQELYEEGRLAQPTFQAFQKAIDCWAFADMDGSTERAERLLHFAEALSDDGDLHLRPTYEGYKSVISAWATSHMNEAPERIQRHIRKIKQRHDMGEEEFKIDSEIYASLIKAYANSGRDDATLMAQTVFDNTPVEYKTTILFNALIAAQGGDALQAEAILNQMHEKYLAGDVNSKPNTKTFNNLISSWSKSGSPMAPWRADSIFKRMEKLSNSGQLDVKPDGETFDTVIATLSNDWGADAASKVDRYLELMRDYFHSGPSDCMPSVVAYTSAIRAWGSNIDDPRAVLRAKALLDEMHELAGAGATSVKPDQNTYLVYLDALSKSAVEGKEGLAQDALISMQENGVQPDDDLLIVLQRCSIPVGAAATSFSVSMNEEPGEFSDVSTSDQDDPLGDKLNSLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSG1</accession>
    <name>A0AAD2FSG1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042247070" evidence="2">
        <location>
            <begin position="24"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="502" mass="54504" checksum="CD64187740719536" modified="2024-05-29" version="1">MMVSTHKLSLVILLISLVSFSLGAKLEEKDDKLSEFFEAREGRKLNGSPQLYFNHLSRTDVRVQAGHTGAISGHMPTNSGHMPVHPPTNSAHMPVHSPTNSGHMPVHMPTNSAHMPVHAPTNSAHMPVHMPVHVPDDCADSGKGGKGKGGKGSKKSCSKSNKRMGKGKGSSSSSSSSSSGKGSGKGKGSGKGGGKGMVHMPSMHPTPHPTHPPTHPPTHPPTMAHVPAGKGKGGKGKGGSSSSSSGKGGKGGKGKGGSSSSGKGGKGKGGRMYQSDHYVAPVHGRAGVDEEDTPDLNIARQSNIHPLDDGAKFDGDEYEMPEHHYNFGPRDAADGDEDEDEYEMPEHHYNFGPRDAADGDEDEDEYVMPEHHHNYDKSDEADADADEYEMPEHHHNFHPLDDTATTATFDGEDEYEMPEHHYNYEKDSDEDEDEYVMPEHHHNYDKTDGVDADADEYEMPEHHYNFHPLDDTATTATFDGEDEYEMPEHHYNYHPLDGDDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSZ7</accession>
    <name>A0AAD2FSZ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001801">
        <property type="protein sequence ID" value="CAJ1952153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSZ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1952153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="308" mass="34638" checksum="75A04A8FBF4D3341" modified="2024-05-29" version="1">MSNVKDAYKNGAEVPETISEKVDIGKKLKLLLRPESVSVIKMMQKTCVNKLARVLFDPGSDESYIHRRNLPTGINGKTVKKKIGTISGKQSLTTQVINIEGIVFPEFSPTQKVESTFETIVFDSDARYDMIIGNNILLPLGIDCCGSTKTIKWMNKHVPYKPPESGLSPQTTDPNEDTSMLMAQLMATHCYHSDPDESLNEHIEQQISHSFNIAESKYDLVPLEHVAKQQQHLNGKQQNNLYNVIKDFEPLFNGNLVRSGKLGPFKGPKAHLKLTPEAKPFQNRPYSVPKSHEAVFKKTIDEMVQWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTK3</accession>
    <name>A0AAD2FTK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001816">
        <property type="protein sequence ID" value="CAJ1953082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="314" mass="35117" checksum="1783641D776BEA11" modified="2024-05-29" version="1">MTITDFTVRKKSYRYLTTQGSYPNHDSKAVLNAFDPTKDLQLQDLNSLVKKGTQRLAKRKSSILINWLDHDVLENGSDPLAFSWPAKAFSKTHLVKVPKLEAWMINEELEQDCSKLFVMENITDKDPETAYDLLVTPKRMPIPKEILDITWDGSAGEVPALCGPLAHGKNGCRERSAFKERRRTCCSHCGLDLEDSTGDSTDKTYELLTKTLAAIEESNKTTKTSVESLLEVVVAGIQGQASDKAPPNTLEKKWPTRLSYLKRVAGTTTSAQLPTLWHELAKCKKHESIGIVQSLLDNEAENLNLNLEFIVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV10</accession>
    <name>A0AAD2FV10_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001844">
        <property type="protein sequence ID" value="CAJ1953828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV10"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="127" mass="14480" checksum="ED9B3A934D5DFDC1" modified="2024-05-29" version="1">METRSAMHILNAPSTKSLKYAIRSGLIKNYPITEEAINHAEAIFGPDASTLKGKSTRPTPKKTYDNFFSPPEELYQHNRSITVCIDHMETENAKFLTCIDTTVRYRSCIPVQNLQFDGTLKYRSNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVH6</accession>
    <name>A0AAD2FVH6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001859">
        <property type="protein sequence ID" value="CAJ1954237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17684" checksum="A3BEEB8A36854D33" modified="2024-05-29" version="1">MKWMIHTSFAVHPDFKSHTGGTLSFGGGAAQVMSKKQKLNSRSSTEAELIAVDNVVTMILWTKLFMEWQGYPIKKNSLYHNNKSAILLEENGRKRAGKRSRAINICYFFITDQVEKGNVKIKYCPTDDMLADFMTKPLQGEKFCKFRDLILGPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWY1</accession>
    <name>A0AAD2FWY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40184" checksum="D4B13F58C8C6F2B5" modified="2024-05-29" version="1">MVAEAGDKQCEVVLVGCGAPMRGMGWYHAVQMLKNKCPSAKLCFIVEPWFMGAGASGPGGPEFAVFQKEAEEKDGVQFFNSVKDLPPIADGKKRLALISGRTADNPRLLTECIEGKISTIYLEKPGAPTVTELSKMRDEANAAGVAVLMGYNKNVCKYVSKAREFAAAHEGSHITFVSNNAYENTPESLGECFERNREGMLKNMAIHELALLVSFFDVKVETIEKCVADKDFSSCQTLKGPSGNDFTDFDKIKFTITTKSGKSVSVSADRCGGDVSWAKVDVNGEEKFRHTMPDEEDNANVTVLQKEYPGAMPYFFSQDPDYITVKEKVADFCANGTEPTGIATIDIAVETLRVAEYLTPTLKEQLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXF3</accession>
    <name>A0AAD2FXF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001887">
        <property type="protein sequence ID" value="CAJ1955436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="81" mass="8278" checksum="36642706AB99F374" modified="2024-05-29" version="1" fragment="single">MRGARASGSGPIVAGHKVSGRVAGKRNCRQGTTVGGGEFREGGDLEVLAAPVEPQQVLLADQGINEDVHQETIVGTVEAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXL6</accession>
    <name>A0AAD2FXL6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXL6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF7">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1956339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31621" checksum="BB14B60568DF13B0" modified="2024-05-29" version="1">MCDDECFEASRTHLHEACVNGDVILVLFWLCDDHADFESKNTEGKTPFHLACEHGHLEIAIMIWSRGVRDLNETDNKGRTPLHLACCHGHLNVVRMLLQESACTEKEDYEGFTPFHTAFANRRVEVACMFLDRGADVNTKSNDGSTLLHYAAVAGAIDLVKLLLDRGANVEAKCDVNGYTPLHLASNTCKPGRFVDSVQLLLDRGAQINARDERAGFTALHYVCGSGDFRVAGLLLDRGADVEATAKTKNDTPLSIACRFGRLEVVWLLVHRYPWLILNQLNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYW8</accession>
    <name>A0AAD2FYW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="48548" checksum="7460961BF699B93A" modified="2024-05-29" version="1">MTQVDSGPGAAPELKDEHKSKSPVSVGQAPSPEEGEGDSATDGFEADTNENSVDVTPGHDTNDPPPSATEESKSESAVPLAFGSETSTKNPKTFCRNSSSFLRVSDLDLPSPDETTTTPYSKETPTGSADGDEEEEEDQLSHFHHPSADPPPGMDKDDKEKFIAIGSHDGVPTPIAPIAMQKLAAFGLETALNQDMWNPDRKTQKLIKKADPEQDWIPHTFSPGPLSVGESCNFHDKEVFVWTGTFSHDYYGCELPAIRVSGTVNMSAEYLVNLLLDSSRVKEYNRLMIERTDVHVFVNDLYNESNNSESNPFGPCVTKFTRATSKPPLVNRLMIFNNLCHAKKLPDDSGYLVCNRAIYNSKQPEVEPVNVINSEVLLGVNLIRHLRDKEGQILTNKCVMTNVNHMRSPKIPMMIAKKIGTNAATGYLNDFRGAAERLAAQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZC3</accession>
    <name>A0AAD2FZC3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042070394" evidence="2">
        <location>
            <begin position="24"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="46560" checksum="C37EA6F575E98B39" modified="2024-05-29" version="1">MITTANRRCIISLVIILVKLSSACLDAFTISSAVKAHHCSHPSIESKPSIQSLKQGENQYTSHLYNARLSYLTLRAGAVDNNADSEDRDRLSVSKIAQGVNTWTQKNFFLAGLVVVLGMAKLFPSWGVNGSFLRPELTVGKYGVGLIFLLSGLSLQGSELTKAVANVKLNGLIQAAIFLAWPFLVGSPLKKVLNVFQVLPPGLVDGLLILTCLPTTVNMCIMLTTASGGNVATSICNAVISNMAGILVTPALLLHFFGTSIQLPFVQMVGKLCQKVLLPVAIGQALRATKAKEVYEKNSKAFKRLQEVILLGIVWNAFCTAFTSGLGLKFHHTLILLTLLPALHLGSLVFLFKFFSIKTLGFSRDEIVAAIFCASQKTLAFGLPLINTIFEGNPNLASFVAPLMFIHPLQMTLGSILVPRISKYTSGDKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G123</accession>
    <name>A0AAD2G123_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G123"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="363" mass="41995" checksum="E78C22792DE3EB05" modified="2024-05-29" version="1">MTSFNLSQPQPQPLPTIVVQLRGELGNHMSAIAHGYGLQLYALELFGLETKLLLRHQVMSDGITSNPKWIPTSQTLQRCFSFDDWDFSQGGRWEEFNTRKMQQENWLDFLELKLMSSVNGRRMKGLVFNDNQPVTTEDIHKGLESFMGALRKQDKKPTIPSFADISLPFLFSESIDNTVLVDRYWKYLRSFFTLDLSSSSCCGDEEPYPDESVFHFRNFATEMPNYKGTLQEATPNQTAFELFGHLGAGDKVAITSRFNNERLQLYVSAMRAREINVRVIEGQSGIQDFCFLTKARKELVGNFQSTFVFWAAILGNARKVLLYTVDNPSLKQRFGQTRRDRFQYQWNSDSLRYRVILQLIEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1G9</accession>
    <name>A0AAD2G1G9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1G9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="358"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1959519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50393" checksum="A973769DF6815F4A" modified="2024-05-29" version="1">MQEGDNPYEILGVELWCSDEKEIKKNYRKLAMKYHPDKQTTEEDLAIANTMFAKIAEAYELLTDPVKRYDWRQANEDRLKRGSAPAVSAVQTTYRPQSGGAVQRPMRTATAPSRASGGSVPTSRAMATRVQQPPPPKKPAPKVRAGLQTTAATSSGRGGRGPPPPGRGYPHPNNPSASTYQQRAPEPHRQARGAKNFRDPFLIFEEVMTEEFGKDYKSQVHKEWSAEDGKKQQSKKSLFGGGKSDDKKDVPSYKDAFKDIDLNGDKVLSRTELRSFIEANETLHAVLGKSLNLHPQQSIDIATDVAFSLAKWDGKDEDAAMASYFLTQKKRKDGKNMDMTKDEFKQFYKNYVQSRKGSYDFFLRTMFAAYDLNGDGKLQRKEFENFLEIFYHANYQGKVAMPSKPELVRLAQLRLDKNKDGHMSFSEVRDLLQVAAVLTDKSKKPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G216</accession>
    <name>A0AAD2G216_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002031">
        <property type="protein sequence ID" value="CAJ1959919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G216"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF18">
        <property type="entry name" value="RETROTRANSPOSON, UNCLASSIFIED-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="658"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1078" mass="121319" checksum="2288371D3C2434BD" modified="2024-05-29" version="1">METHISALVQQQLATSSSRAKPSDKCNKCGGSGHWARDPVCPLAGKKGNNRGKNAGNNNKPKGNKKEDTKWKKIAPGPGEPQQKVVNGKTWKYCAHCTRWSTTHGTDGHTGPKKELMGEPQANLFMFPHAWHVPSMETPLALWNVFQYLMCRALRNIPLLIIVSFLSFKLGAQWSVLKPLLAQIPPMLSFGWSAVYTAFSASWLNMFAPLLWASLLVFGTLPHHLQHQLLGYQSPQEFKPFRMTKPKYKQLVRSCRRKRRPKSFSNHRHTRHYGLATRKRRPLSHRHDRFSQEVFELSQYIDAFGKAILFHCVPREGDIWRALHEGDNWNDWKNKSRKKKTNSETWQDCGGHHGDDPNSTHPSAHCPRCKPKKYRNRPNGAWETSGHWNKYSRWTYYNPNKRASANDWSPHSEAFSSCNIRRQRMRRCNQRNTVYKPTIGNGIPMSQLKVLTSPIAATFFANGNVPPHLNNITERFKAATDPKQAIEEYQKLHRVRKNKVIYDSGASHSLSPCKRDFIGPIQPAPIGLRIKGIARGLHIACVGTTSLLQAYPLEQILQSSTLLTMIGTKDLLSRDNVKQNEATNSIEVAIDPATNLPTSLAYDHGSNSNSTNFEAEFNNFLTTLPLCAGCQFGKQRRRPAPGKTSRVVRDREGALKKDNLFPGQKVSVDHFVCSTKGRLLHTFGKEDDSLRFSGGCIFVDHASGFVHVHHQVHLNTHETLQGKEAFENKCREFGVIVSEYQSDNGGAFTSRAYTEHLRQFEQVSSFAGVGAHHHNGIAERSIQTIMSIARTMMLHQAIHWPDVAAANCWPLAVDQAVFLYNHMPNPTTGLSPNDLISRTRWPQSRLADVHVWGCPVYVLEKKIQDGQKLPRWQPRSTRQIYVGLSKKHASSVPLCLNPATGAITSQFHIVFDDEFSTIATSVDDLPDFGSNEWMKLFGDSIYQYILDDDDDHEPPVDQAPSDLPPLVSRVRDQIEHHRPSEPLDVKPPPTTVPPSVGLSNQQPSLQREIPLSSLQKETPLPSLLRETVNEAPPSQPSAPQREMNATPKEMPQPPTREKTSSTAYTSKNETSSTACSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2G0</accession>
    <name>A0AAD2G2G0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002041">
        <property type="protein sequence ID" value="CAJ1960044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2G0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056761">
        <property type="entry name" value="Ufl1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25041">
        <property type="entry name" value="UFL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="2">
        <location>
            <begin position="149"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase-like C-terminal" evidence="3">
        <location>
            <begin position="663"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="771" mass="86592" checksum="AC88BAA82B1CAEED" modified="2024-05-29" version="1">MGGKSDLNTVPNSAIASLLDQGVSLGFFHTPPSSNDLNAERDDVEMYKQFQKDGPLKHSLDINCQLIEGCPGNYYSQEGMVNVIINELNRVGGRASKFHLCQTLHVKPVFLEANSTILKLLPLSIQVLGTDLISDIFWTNLREAVLRESLEEPVVVAKVCTERSWDVKLALDCLVHHTKNEEIKGEIHMDTESMNLATATFTPSSYTNKQQDEVANFLEANGFISKARALRHGLSLLKIEQLAKERHQDVIILEDFLIAEHTVLQKLQASIELCIENGISDLQEYIPAELIRQDIIFELLKRVTQSSNQCIPVICKVPLVQSFAKAKAEEIIDENRKRETDDDEDEITNHGGKKNKSRSRKQKEKHSNKHIDGVGVVPLQNVAQRMIDLYTTLTVVDADVEDIASLGDRFEWEDENDSGFLLIEFCKCILYTDAFQSQCQSAVLAELKRLESAKISKSCLSRKEAATKIRNVDSAFEDCFTDLCYLIQASSKFHLFASGYKDVFDVATVKGLQNELLLGYCADLTSRITQYCLYKNEEEPLFTFKSEVEEEKAKEESLIPSLPPFCMELDFTATQPIRSYLSCPPPREPLPVLRECLDSNKGVTLARQWILCGGESYRGGVRISEEGSSIVREGTVDGFLNHVQENCLTLCGLPFKKLDKKAEKQLLFRRKVALMTMLEETTDPAKVLNLTIMLLFQQVKHMVVYGKYLRGSILNALVKERKISESVGDVLQGLNDRIEKGLSISEGYLNAAKGCALCKDIGKHEIDFAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2X1</accession>
    <name>A0AAD2G2X1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prolycopene isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2X1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016116">
        <property type="term" value="P:carotenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045892">
        <property type="entry name" value="CrtISO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313:SF3">
        <property type="entry name" value="PROLYCOPENE ISOMERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="65758" checksum="FA2F5D09567F8AA0" modified="2024-05-29" version="1">MLKQQSATSSNKEDDTVDIAIVGAGIGGLCAGAILNTLYGKKVGVYESHYLPGGCAHAFDRKASNDETFTFDSGPTILLGCSRQPFSALRQVLDAVNQKVDWIRYDGWGMIENPGKENGNEKRWKCELGEDIFQQGPLKEFGGPNVLEEFEALREATKGLITGQSIPIMAMRPGPSALVPLLRYFPTLVKLIQQGPELTGTFEPYMDGPKFIVKDPWLRDWLDALAFSLSGLPSSRTAAAAMAFVLDDMHREGAALDYPKGGLGSAIDALVRGLEQGKTGSKLNLRNHVESIDFNDDATMATGLTLRGGQKVIAKEGVICNAPLWALRNLLKDDAAKNKIDNYLGDDKGDRSPRQTWEASGEGVSFIHKTRSAVFDKSKKEEDERESLLYDCDTSEMTGSFLHLHVAIDAKGLDLSKMEAHYTVMDRGLGGNENITIEGVTDGPCGELNMIALSNPCVIDKTLAPEGYMVLHAYGAGNEPYHVWEGMERNSPEYKQLKEKRSKVLWRAMESIIPDIRERVVLDMVGSPLTHERFLRRPRGTYGAATEDYLNDGSTPISNFVLAGDGIFPGIGVPAVAISGASAANAFVNPFQQWRCLDSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4P2</accession>
    <name>A0AAD2G4P2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4P2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="85" mass="8952" checksum="67BF2DFEF4DDBBC6" modified="2024-05-29" version="1">MAPNDKTPGSKLDSALNNATTKMNNVHEKVTEATEEHKEAAKNNAEKVGNALPDSTKEAGSKLGGMVDSGVQKAKDALSDNNEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4T6</accession>
    <name>A0AAD2G4T6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ORC1/DEAH AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002116">
        <property type="protein sequence ID" value="CAJ1962758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4T6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC1/DEAH AAA+ ATPase" evidence="2">
        <location>
            <begin position="158"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="780" mass="87269" checksum="110BAB62BAF2E26A" modified="2024-05-29" version="1">MPKTASDDDDTGGTKSSRNSQETTDIVPPDDEKTLGDYMANEDEWFKDDVTDIEKKTSKSQLIEALKVDEDYFKPTQMRLTIDLAHFLKTGESRPSISKTAAAASQRVTDIDYDIRDSKMVYKRDLKAFAARLDKLFEWKNIHSKEYMAPYFPLIQSSGTGKTKLMHEYKNLMTMDKADVHVELILCTDGNEAKIASAESIFSQILDIREIQSDQNGLTKLWNRLNRFADTEKKKVVLLFDESQHLTSNSDGWHFRSVRWWLRWPNKPGNVNVVCVFAGTTTRLANYYAEPKPSTTSRDANVVYLGGDKLYPPFYQLTTTGLVSRTDGFKFGTVGGTHKTPLQKRNEETITELDVAIQYGRPLFGRLYLKGQLKTSLGNILLRMRGADQELSLQKYYSLLATRLQMGQVSFDFASELVASGYAHLTHFSPDQTAVAGIAFLPDPVCAWLAMTQMIEGCNRFGIDDGIPTECSEPASVWSEKAIKIFSSALCRPAKGDVGEVAAAFYMLACGDELRFEQSTDLTQLSVPLEKWIARLQHADLNTTLNLGEAKASVNFIQVCQNYLRYSLKEMQDSGLLKHWYLGGRGSYMYFACAAYDIMVPVQYTVNGTLHYCPMLVSVKNKVEFWPYERKAAIKAMQKLFTNAGIQTGVCLLLLIGLDNTSEKKTRKKTRKKTKSGNSFGHGQIFTVTVVVPKEDRFGATNLALCSTCGGGQESEVMVSHAELALGADHSFDCLLRKKNEDDGLSQLLFEEIREGYANISIDEDDFGGATAPDESRGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4V4</accession>
    <name>A0AAD2G4V4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002124">
        <property type="protein sequence ID" value="CAJ1962820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4V4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="243" mass="27291" checksum="5C781E08BC555D29" modified="2024-05-29" version="1">MVAELGQYVHAIGTDSSNMMDPQSIKAIYIEPTKGQRIGHRVLNLNTKKMISRPKVVVLPVTDQVIQRVEAWAAAKGVTFMKFFNKKRDLETFQDDDQIAGVDDTEQDADNDVDDMPELTVRFQGDDDYESDEDLGDEGYEEEEPIVADLDHHQENVDRGTNDIGSLVTDLEDLQEPPEEEILFEPEEPQVAKVTQSGQTYAQAAMSGLNLSQVPKKSREWPSSRSGSSANKNKNRVATRRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4Y3</accession>
    <name>A0AAD2G4Y3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002134">
        <property type="protein sequence ID" value="CAJ1963136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4Y3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="434" mass="50111" checksum="6D53EA396EFC11BD" modified="2024-05-29" version="1">MVFDWLLDQWAPTLRSPPRVRIACDGFSALLNTFSDNRVTPQQAQFDLVSSIREALARSRASWEPSHMYGHLDQATSFSCLSWWSKRNVEVDAWAVAYRHQLEASHRLIAPNARFFTELAALYIGDVKQSRLNPEQVQELVALPALRKRWHERQTITPEAELETDWTSLARAMSSLPAGVQRWTTKHVVGMCGVGKFKVRWGTADSAACPCHGEFEDHLHVPRCMAPSASAEWERRTATLDQWLDTQVTDPAIKHAILYLLQGVRDPSLPRSRLVPVRLRRAFLSQQRIGYQGLLEGRLSVQWAALQEQYLQSRGSQRSPTLWVSRLSHQLILLGFHMWEHRNSVQHSEDNVQLRERSRLVNDGIHSQFDMGPTDLPKVVQRMLAVKRRTVLNKPLVDREEWLKLVRMERTAYRRALAPQRRILHRFFHPAQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G648</accession>
    <name>A0AAD2G648_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">glutamate synthase (ferredoxin)</fullName>
            <ecNumber evidence="19">1.4.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CYCCA115_LOCUS19893</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="18">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Nitrogen metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.7.1" evidence="19"/>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016041">
        <property type="term" value="F:glutamate synthase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000061">
        <property type="entry name" value="Glutamate synthase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050711">
        <property type="entry name" value="ET-N_metabolism_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11938">
        <property type="entry name" value="FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11938:SF133">
        <property type="entry name" value="GLUTAMATE SYNTHASE (NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="16" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="20">
        <location>
            <begin position="84"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAJ1962869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1594" mass="175002" checksum="48E85112DEAB2201" modified="2024-05-29" version="1">MLSSRALTRQGLRVNRRFLARRSQTSVAHKSFRRAASRPLGNSLKRLPSVLPYSTEQILKSRDSKIDLSKQRILYDAKDEKDNCGVGLIANLKSKPSRHVVDVADEMLVRMSHRGGCGCDPASGDGAGMLFGMPDSFMRLKAKENFGVDLPEMGKYAVANIFFPPASDTRSIMGDCKAIVTRLAKERGVNVLGWRPVPVDNSMLGKEPLNSEPITEQLFVTMDKAQDQRAFEQDLLLVRKMAETEVQEMLGPESGFYVNSLTTTHITYKGQLTPEQVSQYYLDLQDPDFLSHLALVHSRFSTNTFPSWERAQPIRMMCHNGEINTLRGNKNWMYSRGGIMESPEFGDDTTHLLPATSDNMSDSGNFDSVLELMTKASSRSLPEAVMMMIPEAWQDNDNLSEAKKAFYEFNSCVMEPWDGPAMVAFTDSRYIGATLDRNGLRPSRYYVTKDDHVVLSSEIGVCPELPDSEVTIKHRLEPGKMFLVDFETQRIVPDDEIKEQIAALKPYGDWIENHMIDLEKWTAASGTAREPMDFAVTNRKLNLFGYSSEKLEMLLLPMAVGGKEPLGSMGNDAALAVLSEHPRQVNDYFKQLFAQVTNPPIDPIREEIVMSLVCPVGPEGNLLDDPNETHCQRLVVKSPVLSLEEMATLKNDEFKATTGGPGFKTTVIDTTFPVDAGVDGMLAALERICDQAAEAIQGPAHGKKGVQGIILSDKFAGPDRMALPSLVAVGAVHHHLIGTKQRPKAAIFAEVGDCKEVHDFATIFGYGCDGVCPYMAYEAMCKMNADGMVEATAKREFTDDELMTNYRKAAAKGLLKVMSKMGISTLQSYKGAQVFEAVGLAEEVVDRCFTGTTTRIQGTDFEALYRDMERFHDDAFPRHSQEDDILVRSDGQFHWRDGGEAHLNTPGGMVNLQVAARTNSRDAYREFSRITNEQNQKVTLRGQLKFQFDPSKGIPLEEVEPVSEIVRRFATGAMSLGSISQEAHETLAVAMNQIGGRSNTGEGGEDPLRFKDNRRSSIKQVASGRFGVTSEYLANSDQIQIKMAQGAKPGEGGELPGFKVSQYIAKNRHTTPGVGLISPPPHHDIYSIEDLAQLIHDLKNAQPHGEVSTKLVSEVGVGVVAAGVAKAFSDHILVSGHDGGTGAAAWTGVKGCGLPWELGLAETQQTLVLNGLRDRIKLQTDGQLKTGRDVAIACLLGAEEYGFATAPLITMGCIMMRKCHLNTCPVGIATQDEELRKKFTGQPEHVVNYLFFVAEEVREIMAKLGYRTMEEMIGQTQHLEVNRKGQHYKSRGLDLSPLLTPAQELNPSAGIFNTTGQDHGLDKKIDNSLIVRAKDALENKTPVVIEDVVNNLDRTLGTMLSYEVSKRHGGEGLPDDTITVNLKGHAGQSFGFTLAKGITMNVEGDANDYTGKGLSGGKISVAPSPEVIKDGFKPEDHVVVGNVCLYGATSGKAFFSGKAGERFCVRNSGALAVVEGVGDHGCEYMTGGVMVCLGETGRNFAAGMSGGIAYIYDPDNKFPTRCNMGLVGLETIDTEAEKQEVFEYIQEHVAATRSGVGQEMLENWDERSKQFVKVFPHDYKRVLEERSKAMEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6C2</accession>
    <name>A0AAD2G6C2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002183">
        <property type="protein sequence ID" value="CAJ1964424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6C2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="351" mass="40548" checksum="ACAA62C23A386820" modified="2024-05-29" version="1">MNYASRGEHDPKAEQSNQHLKALFWVHFHRMPFKAIPKKLTVALMTRVAKISNYYPAKGGLSEYYSSHMIMHQRMVDASKEFVAEIGAYVHGYGHDTKNNMAAQTIEGVYMGPTDNIQEGHRIYDLNIKCKAQRVEIKVLPMTDQVIKIIEEDARLEGVKELRTYSKRNGKLILDGDLLKGVDPDELWDENYVPANKIERLSDVTLRNENIPDDELDELLMDAEADIMEARFDRDGNPRYNSEANQDEDELEDEMFDRMFKKIKAKQDAEDLMDKAYQEHEWITANEDMDYKDEYKSELEDDKAKQMLDELAAELVELGKPDKEEVLFDFDDNTQEDVAVESEEEDGVACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7E6</accession>
    <name>A0AAD2G7E6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS21234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002213">
        <property type="protein sequence ID" value="CAJ1965641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7E6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF92">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="74"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1965641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="200" mass="21733" checksum="29414F00AD38999E" modified="2024-05-29" version="1">MSNDADKKVEADADGDDDDEDLEKLQAEIKRMEEEAARITKETEELEKKKGDSKATTDTAKASAPADAPSQDGHSIYVGQVDYSATPEQLLSHFEACGTVERVTIVCDKFSGRPKGFAYLEFSTDAAVQNACKLDGSEFLGRTLKVHPKRVNVAGFNQQPDAGGRGRGGRGGFRGGRGYRGGFRGRGYRGRGRGGYHPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8D7</accession>
    <name>A0AAD2G8D7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8D7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="316" mass="34235" checksum="D2296A867BBB2A4E" modified="2024-05-29" version="1">MCKSVGTYTICGCLFLYYTGNLLHTHGSYNWKIGQHGIGFGADLEAKDENGDTPLFVACGSTDLRVAQLLLDYGADVEAPGGEGHFTLLHVAIWGCSLEITELLLTGGADMEARDVDGSAPLHHASVRNRLGHMDVLINRGANLEAKNENGETSLHLICRSSKNHVDNGVHLLLDRGANIEAKNNSGRTPMHVVTGLSASPMLLDEGASLEATDRRFDATLHRACSGHNSSLARLLLNHGADLEATANLGFRPLHFAAVNDFPNVVRLLLNRGAVVLVDAKTFAGMTLLSLACQKEKVEIVWLLVRRCPWLVDWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8I2</accession>
    <name>A0AAD2G8I2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8I2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="274" mass="30480" checksum="689612FCE0E0B05C" modified="2024-05-29" version="1">MATTTRPNQKPGKLSSKFGAAFAAFENNSGESNVPQAFRSATTTRKTKPNTTTGQTRRSNSSTPLLKKHHHPNVSSSSEEKPRTRFSQSNSFQRRSVSNTEKASEMDNNKHEQDQPSAQTPSAAAERTNSTAEDMIALPTTPGKRNFRVSSKLVANRAMVFESSNSKNNSSSTTTTTTTDTALLAEDKHIDDDDSECYGYIDLAPVKETVHSTIDGVCSDGEYEEFWEEETLDSTEEADDWTYQSWEEETIVDDRVLLEEEENEEEVVVAVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G981</accession>
    <name>A0AAD2G981_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G981"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="2">
        <location>
            <begin position="420"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="596" mass="66672" checksum="D04AF23A07F1C883" modified="2024-05-29" version="1">MGDPPIDNARAELGGGAKALSPTNKPKNKREKRKIANRARHRLLSIRKDANAIEDVIKPLLIADDAVTVHDDWPWIANKQCGSWYLPKPTLCSCYFKSTDGHVGTYNVSLKRLNLPLLKVLSGHQGCVLVDSSVRKLLPDSFSRTIPIWACVLNRIAKRYREELSGDGGLGSTSSITKYWNDTDWDVGLYTPASVVSPEEHIVISDLIDSRVDLLYQSKAIVDPEGLAKLLTKPVRAVWWSNGRYHTDTLSSAVNESLDWDKYHVIVCCNPSSYIEEDGKLLNKNHIQWQDGPGDNGFYYTPGAADDHDTWARGLTPELLWMHEHSLGDLSSLTEDHVDAIIDDVVKSACQDALGDTPASPQIDAKNANKIGESNLWIGSRRAGRPPECWDSFDAILNVTENEYPNMIKSMETSQKPCFYLQLVVAEGKRDKTQLERLLPLGLAFLLHHMRQGRRTLVHCAQGKDRSVAIAVASVALFCPKVYPLKLSPRCEEWDLELLCKGEVLSIGELEQGASLYGHSGLPLSLIRVLLSESARDDFLRWYHACSKVPTSTSLATKESIRISLHLIQQDREVADPTRSTMQKLNRFFMSSSMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB61</accession>
    <name>A0AAD2GB61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS23144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002369">
        <property type="protein sequence ID" value="CAJ1968233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="226"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1968233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="513" mass="56266" checksum="F4C6844E3FCAA306" modified="2024-05-29" version="1">MEDSDQDDIFASPSRKRGSDNGSSQSNGSSSQKKKKAKRTNDVVVVKEEDSFRSLAMNLPVASFSTTTGTTTTTTTTGKKKKQQLQQTERTSPTEEIDLSSSSGGFRSLASSLPVASFSTMGGGSTKSTNGIKKEEAPSPAPTTKTVESAPNSTGKKKKKKKQLPLPNSTETGKKWTKAVVKCREHDRYAPSFDFAACKERCIEAGVTAEWIKAKPFGKWCSGNPQVIAIDCEMCETTDPESGSRNTKALCRLSVINAERPDEVILDTLVKPSWPVSDYRTKINGISKEKLEGVEFTLGHAQSFMMSLCSDETVIIGHAVHNDLVTLHMEHHCVVDSSLLFRAKDSPTSSASLKDLVSGIFKEKMPAIHDSVNDARKALDCALHWVKNDGKVADIQRSTNNARAAQLFVHRVPKHCKADHFISMFQNHTSIVPDEVDEIDFNGDTGRTHVTFKSYQHANLAFNTLEGASEGDKSGRLQKKVYLKGGGYVRIRKMVHERSSETPDKQRSTPDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBA7</accession>
    <name>A0AAD2GBA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS23306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="VTC" evidence="8">
        <location>
            <begin position="183"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="554"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="935"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="959"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1026"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1968581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1130" mass="127784" checksum="247BBCE8056ACD5E" modified="2024-05-29" version="1">MRIAVMEGPKDLRKSLEQALHDMATQGPEKQEQFCQVFANALQFVERAISEEIAHHEQYASSLLRSIELTISVPEHQSPQQEADFRQAAQAQVHNSKLLSANAKRFGQMLLDVSRLADTKISTDITFEKTVQERLLFEPWAQSSFTKIVVLFSDVFEALRDLKEAASASGKAGVWVAPDSFERKTTKYWVPEENLPELLMTCASEAPFLVYGKTGRLSRAEDIPLDDLWKNLSSKISSIYFDSPSLALYKERIKRREGAQLLRARWYGEKPPKPDQPVFLELKTHHESWIFAKSVKERVAILERDMNAFLYSMDSVMSEGYAESLVLAATPKLKGEKLAKAIDLLIRSHTLVVRHKLRPCVRSTYDRLAFQSSKSNSLRLTLDRKVVVSDERGCKQGEQWYVPFEPYESKPDGSDRRTIPFAVFEIKLGEGQESTALNECIDNGTILDAAKFSKFLTGAATFNTVNHLPYWADHPAFQTFFYQASALSSSKLSSVRDVPYNNDGEISLTATGSSDEAGLPGDRKSSKKFLSFLPQRVRGNAFVAPKKAVRIEPKTYFANERTFIQWVSAALFLVTTSAILLEAENGEGYAKLTATTLLIFALIIAIYAVGLYYSRLWLLTNARPNGYISHFGPFVLTSAAIAGTWVILRQIRLVEFQEELERSVEEARNKVRFVQADPGMCMEHDISSFSPLEFEPSDALVDLQRNQLLVPSLSEIYGFPLPEWNSEGVLEIPNVSSSIVAQVELADFGSATLVDDDTLYAVSEIDITTLEQSPQMYSFERGDFGRFEVTGQWKLETPEPEGMALVSKGRSSSLLVSGQIGEGPLSAVIKRFDVPEPNGAPISLNDNSTFVPTTPTLEASRNLNEKLIDADMEDPKIGAMTYFEGVLYVLHEKGKVVRAWDMETGTFRAEWPLPGVPNSSGKQWEGLAFQRIERPRRATAIERSSSSNPKNNLRRRRIQTTDDDPRWRDDDVQGTDDDPRWRDDDVQGTDDDPRWRDDDVQGTDDDPRWQDDDVQGTDDDPRWQDDDQEEEGEENNVQLNEEEDEEAEDEDREEEEDEDQEEEDEDREGEDEDQEEEDEDREDDIEEEEDTSVLVLHLTHDTPAAIWSIVVKEGDMKGSIEYPPCADVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCJ2</accession>
    <name>A0AAD2GCJ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS24102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002458">
        <property type="protein sequence ID" value="CAJ1970079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="598"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="292"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="614"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1970079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1042" mass="111353" checksum="53750627C3CF4DBE" modified="2024-05-29" version="1">MPHKGKAPSSRRHKSGSSRTSSGRSNAKTREAGEDPSEPSHASNLERSERSTHSNHISSSHRSAPRSPKKDPERHSRASSGRSKTREAGDPSESSHASNLEKSERSSENTAELRSGRRSPAGSGKGSRDSADRKKKRSGPRATKPGAISSTSSRHSDAKSSKPGATPGKASSNADVRKKERGATKASKPGATPGKASSNADVRKKERGATKASKPGATPGKASSNADVRKKKEQRSTPSSNSGVVSEDLMTNRERQEEEWAVSSSLPSPEAFSDGNLLEATTVDDNLEAPEVVQMRREFEQKENRRQQEIEELNQRLAKQEKQKKRRNRIIFIVIACLVVLIGAGVGAYFGLNKDTNTEDSITTNGNAEDLTTAPSSVTNGGNNGASSTPTNAASNGPTVTQLYQPPSDDNCLAISRNETIDGQGDLDQSEFDMAFDVTLEANGDITDPQVQTFLDAIQETLLPTLAGCSGPKINRRDLLAKNELPTIRAVAAQPRQRQLAIGENRFVIFNAFVTGREDPDVVCTNTQDSNRCHRIVVKVSAILKGPVQLMDIVVLTSAQVTEKLKEDEQDDGNLKDPWGLGNPFSEVHLVNIDNQSATSAPVPMPTIDPGEDSSPTPTVETTLIPTQMSASGLTSQAPSSSPSMITPVPSVNPSAAPVTGPTQPPSALPSIMPSDTPSLRPSSFLSSSPTLAPVVGPTLSPSSTPSRVPSVVPTLSPTATASEVPSAYPSIKPSIVPSANPSIKPSMVPSAYPSIKPSMVPSAYPSIKPTMVPSSSPSLIPSVSPSTNPSQPCFQSSSELSSEVNNFFGTALQKAAVENTYGPIGDWCFGAGVTSMSQLFKYRAFNDDISNWDVSSVTDMGEMFNGASSFNQDLSSWDVSSVTNMALMFYEASSFSGDLSSWDVSSVTTMSFMFRRAYSFNGDLSSWNVSSVTNLSFMFRDGSFNQDISSWDVSSVTEMSYMFWNARAFNQDLSSWDVSSVTAMRGMFQGATSFDKNLCSWASRLPSNAHVLYAFTSTHSCPSSDHPSLSANPKGPFCHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDB3</accession>
    <name>A0AAD2GDB3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS24397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002503">
        <property type="protein sequence ID" value="CAJ1970378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDB3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="519"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1970378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="565" mass="62668" checksum="2FED42D148869615" modified="2024-05-29" version="1">MAELLLPGKDVDERLAAKAALESSEEKLRSLCASYAGTFVSVERRGHGLEQKLRKLLESAKSIESRVSTCEHSLEQEDESDGSLAALSEKHRVRRRTLLQHSTLLELLELPSLMDACVRSNLYEEALSIAAFANTLERRHAEKNDVVLKVISQVRSRQSDLRRHLLFCLKSYVSMPQCLEIVTALRRLNSIDLERQSESNLERVHGAMELSLQVDFLEARDVWLDQPSTNGESRPGSVGEDASIRAGSEQLLDSIERYRTRMFEIATQFNAIFRAQANSSAIAASLLNMWAVRRVRSFLATLEDQLCVIDNSASLRDALDSCVFFSTSMGRLGADFTSSLAPLFESKMHSLVVASWTDGVHQFADTLKICRDAVVAAPLVSSTVADAVSSEYIADGSTLPPPRQLMALPPLGRLVNAFLSGLNELRRCLLPGIFPKLRKSLQAALVDIDAILQANERAVLTPGLRGDASELRHIAREMKTTMKGIVTPYLQGALEHALGNKEGARRHNDMVAATMTEPVGGEIIDKKPEKDTEDDTETYSTEVKKSLPYQSKLMENESEKERTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDR3</accession>
    <name>A0AAD2GDR3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002505">
        <property type="protein sequence ID" value="CAJ1970387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDR3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="234" mass="26565" checksum="A46CF22DDB8B5DAA" modified="2024-05-29" version="1">MQQAVVDRSGNGTSDTTDVPGSYVVRGRSVADERSNGRITGWNLTQVRVRPILKKKAVSTEDRGELLMKKWQAQLEAANTFKDNDSMVSNGSVNMQIYKSTSKMYSLKHCSQWTKENKKPFKSNRSKHWDINLGVHLDSGSTFSLRMNKDYTKPGTVSDLDYMFKYGTNTGQCNLHQQVESSIIEGHTWLLDTEAQCNLDSLSELVKLGFRVVMDTDIENSFMVMKGEHFCTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDS7</accession>
    <name>A0AAD2GDS7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002513">
        <property type="protein sequence ID" value="CAJ1970417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDS7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="663" mass="69366" checksum="0133493BB633F46E" modified="2024-05-29" version="1">MNSNNNDEVLFGDADEKAKAKASRGGSSKASSPGAVSMSDSKETSNNKRSSRGSKKHRSKRHKDKHSTSSRSSSGKSKKSRSVDETLYGNDDDDAKAKAKASGGRSRAAKPGIERVEESAVPKRGDKGYVADPLFRGENQNKSPNHAAVVQNSSNSATAAGIVVDENGVPKVKDNPKDMDALAMGGNFVETDPDESKDSERRNSNKKWFILVAVILLVLVVAGVGAYFALTGGNDEQEQVAQERTSAVPSSAPIVPLNAAPTISPSWQINDNWPSKSDCDAIATNGTIVGDVNSETVDTFRISFEVKMSMNVAMSDYSATELAMAIQKWILPALIGCDVNTTTRRELSEVARTGIRGSTENRKLESEEWQLAISNAFVKGKRMPNQSCRENVSSCQIVEMELYLFLKDVIGDLSARVRQEFESGTPLIDVLHLDDPFVSVELVDLSVLEFADAPTESPSKSPVIPVNQSPTAAPASGSTPPPVADPTLSPITSPDANPTEAPVQEPTETPVPEPTEAPVATPTETPVVPPTEAPVVVPNEVPVSSPTSAPTKEPSPLPTPGPTPIPTPSPTKAPTKPPTQAPTKPPTKVPTNTPTPAPTPAPTPAPTNAPTPPPTPLPTRVGLTDNIPIGGDNGGLPGLGPGPGGQGGQGGQGGSRIPGGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDU1</accession>
    <name>A0AAD2GDU1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002419">
        <property type="protein sequence ID" value="CAJ1969003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDU1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1969003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="267" mass="29929" checksum="7D22BA56D91F4FF5" modified="2024-05-29" version="1">MTEELEGEEASYFQSLVGILRWMVELGRIDIITEVSMLASHLALPRRGHLKSIFHMFSYLKAHHNATIVMDPSYPQIDHSVFKTCNWADMNPGATEPIPPNAPEPRGKSIDVILYVDSDLAGDNINRRSCTGYMIYVNNALVIAHSKKQARIETSVFGAKFCALTQGMDQMRGLRYKLRIMRIPMEGPTYAYGDNMSVIHNTQRPDSTLKKKCNSIAYHACREAVAAGEMITGHVPSEKNPADLATKIVPPGQKRDGLLDIVMYDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GE60</accession>
    <name>A0AAD2GE60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1995 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002491">
        <property type="protein sequence ID" value="CAJ1970264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GE60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053021">
        <property type="entry name" value="Chloroplast_ADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018962">
        <property type="entry name" value="DUF1995"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF1995)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF1995)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09353">
        <property type="entry name" value="DUF1995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1995" evidence="1">
        <location>
            <begin position="9"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="299" mass="32254" checksum="732BD18D3A6E2729" modified="2024-05-29" version="1">MVQTDVSLPKDVKEAVSRCRAATQEALKDQLSRMDIEFPVGTKFGVEKIPKVKGRTNEGAPTQTVLDQSDRELARLFVDMFQPVGGDNIVVAFSEQSLADAAKKKWKGDPTASSRIMAMNKRKASGAAKKKNKSKARGFAAKLAAEVEDSPDSGGPFELPDGTQVALFVSPGPKELPTIEKICSDAGMGTCVILLNARLSKISNFGTDEAAKLFQGDFKSVFALTAAPQESAPDCLLYQAYPGPWTLARKPKVGQPKPILTQDTRPTTEECGAAYDNLELSDLEKGVENALENVAGWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGB8</accession>
    <name>A0AAD2JGB8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001726">
        <property type="protein sequence ID" value="CAJ1947428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGB8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="668" mass="76119" checksum="01863403943613C0" modified="2024-05-29" version="1">MAVTPKEKDIESAIDILFPKWSEQEEVECAGNLSFELLFMAMCQTFDLTTVGGWLKLLKRLVVNKSPPRMQNIQVLRCYTSLIFANRVNLSVALLTGEEFVFALKQQTMSAAENLLPDRGQKEVCTSFRLLKDDFGLDYPRLKRYSHQQRALIAESSESASLKDFVIENALRITEIGSNFVAKVNETTDLDQYTIYLQENHEFALNLLLEVVEYNSQVWAIVNSHVKRYLVQNGREGEVYGKGYPPCEEFLKKMKASRFNAAPSRKKVAKEVALVIHLLTQFDDRASASALFFLLCKDTECVFLPPGCTNQLSLNLSCYVSFWDDFFKARQNIAEIVYCTYEAKKKGKVKASKKILQDMLARKLSKELLDAIEKHGKGFVCTIMELLFMVAAESSQERTHNHIHLGSALTTMQLGSDIEFAKRLNASKLLAFSHHNQRSDKSLECCITQFCNGSPRLLSQIEEYLRGKEVTNDAKKAQQAHKKKARGSHTNSRSTSTPTSKEAEESDQGETTTPTQDSRMSHVDAREEEGTDSGPDENDDTNDLQLSTGKKRPREDNDEEARTSLEDEASVAAEVAERKMALDRKEQELLIREKFLQEKEERLKAEQQAFDNGKDEELQKSQLDKKRRDLLTLEEALREKEQQLEKQKEAQKKKVKKLKDENKSVNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGU7</accession>
    <name>A0AAD2JGU7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGU7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="24"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="226" mass="25760" checksum="E98698158EB94425" modified="2024-05-29" version="1">MAATSPSLLPVSPMASEEEREQALRDYKVTIEYKHLKSHAPGGVFLIPGMDNLRQFYGVIFIRRGPYSNGIFKFQLKLPPKYNAENQHPVLTFSAYVFSPYVDETTGILDIKNAYPKWDPTRHYLVTVLTYLKKIFYTKSFVDAKANDAAKELATKDPVAFRKKIEACVRESQKNMYSNDPGSTAKFTEEEVSHSVLRDLLKHHVKDESKVTKQAVLAQIEKARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH31</accession>
    <name>A0AAD2JH31_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="475" mass="53226" checksum="C30A518B078C1FC0" modified="2024-05-29" version="1">MDVNELSYRYQGNEGETVPKTVQKLTFSSGIQVLPDELCYECRDLQEVTLPERLVKISDGVFYRCTSLWEIKIQCTVESIGDVSFMFCKALKKVEFEESSSSTSPHRLEIIGNAAFASCSLQRIKIPSSVNTLGKSAFDACNVLIEADLSTTSITEIPRKIFSRCRSLQTVRLPNSLERLCDYSFFSCIGLVTVIVPIDSKPIKIGEKVFGSCRALANIVLPKGSTADEDVFVGCTLLHGRFGGESDGIVDGLVHRFDTFPVHRICYDNSSVTTQELGECIQRTKDNNKAPFVDEFGMTPFHVLFSTISPREDLLEGLLEKYVDHDTGILDSKDANGKQPLDYLVTNWTETSAPLLETTLQRWAIDPLVHWGTTTWMEDIQRKVQAILLAEDDNELREALYDGACSDFAHYRFMEITSIFEMALWKGRLKGICSNDGAKRQALEREECRCVCGSHIVIPNVVQFLEIPRATSQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHC3</accession>
    <name>A0AAD2JHC3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="596" mass="67880" checksum="5106898E474FB49F" modified="2024-05-29" version="1">MTNYITTFVNQESFKSISFPKLPRMSAITQQQQQQQQQPVQETIITGLVCAVAIVLLRYMVLDTYRTYQRLCRQWKRRQPPVSILRRPEGGSRKKKRSWLGVFTRKPNRVRFAKIFRRTFAPNNQELQSRRECWGLIQWRIQLHDEVIPEIENTVRFVPHTPVSILRPSRQDWGSPKPTSSSRVQFAPKTRRRNFIPDEQDLQSRRQLIRQIDRKIKRRNARRLMIDFKPTVLATIIEDPAEEDSSDIDSSLDTGFIDGKIDSETIAIALEDHRQMLPTVLQDMLSNIPVPMDLDDDDNNDDEPCMEEQAPLSLKRTATSCLISSRPTKCRKMNSSSTVPTCAATWAKRTNELFTPLLPVLIEDPEEGGDESDIDSSLDAGFNDDIAKERSTHLAKAGAIWVKKAEEIVAEKANLNKKTKTERAKWANKARARRSKGQNEKMSEKKIDFEPTLLVIIEDPKQEEEEVDDVNEKKESKTSLLVIIEDPEGEDLSTMDESPFDAGLINDDFDSLEQDGSDGEIFAAPTEQSDNAATNDIPSDGMGSGWTESGKRYSRRLQLKLSPDKKDPSTEALGSGMTEKGRRYSRRVVNRGKGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHH7</accession>
    <name>A0AAD2JHH7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001763">
        <property type="protein sequence ID" value="CAJ1950345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHH7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="533" mass="60890" checksum="3D652B1A37F5B73F" modified="2024-05-29" version="1">MNSTKNESSCNPESTGSCDGDEEDTKETMSLTTCTGSGYFAAIQSRIHIYDSFRLARIILGSNIKSFNGSLDSTAIFEAITVVAEMKMELVQLQGKVKQLEARNIIGEASSEDQFGSKTSEQQKLLEQNELLKDYNEQMIRLHASQSRTVDILSNWNGGHFDVDAGDASVPNEEAVLRVAKESTEKSKELLARANYLFETSQKQLTSCRKQIGKLQRQIQTKSTIQHIELESFRSKHARQVMDLCGQLEAYKEQVETQHEEMLRMQERFHELEALAVTPKQAHDVLQAINQIAEDSSVEEQMEVQSQVVEILQRMSQMYTKQVHDDAELHAILEAAKRKEERSNEELQDLKLQEKILLEETRVPAKDWREALAAQRTLCERQISDILSREESRLLEMEILELKLTELAFAAVEIEDLRDELQEIRDQHDDKITEINSLAVGAESVVARLRNQIEEIMEKQMQSIRHIEPSKSKKWRALLDRKKTIDNLDQLEMKLVVQNEELFSVKEELSQSKAKIQLLEHKLSIAAGTKGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHL5</accession>
    <name>A0AAD2JHL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001787">
        <property type="protein sequence ID" value="CAJ1951568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="165" mass="18481" checksum="19DE28B5B040E803" modified="2024-05-29" version="1">MRPLTGEAVAASSHEMHNQYGATDEFLKEANWINNVHMDEGRCVLTYMWGDLFRRSNAEGSILHDKLGKKGMEAPYLSSHYSNRGPNSRYSNGILGGERGSKMMTNSAARNHVGNSERRAPLPEQHIANREISKQLLVNSERIPPQPELHTPSRVTLDEESKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJI0</accession>
    <name>A0AAD2JJI0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001890">
        <property type="protein sequence ID" value="CAJ1955485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJI0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="131" mass="14378" checksum="16B7211B69288B1B" modified="2024-05-29" version="1">MVEAHAANNLQIGPIAEQHLATFNARAPKGTELAIPTDATTCQAQALDRDRAQLQNEDAQALADSNSVYRHVEIELFGGAKAMICMNIVLLRQALSLPNHKSFHQGIYNEYTDPVLPDGADMEDIDHLNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKI1</accession>
    <name>A0AAD2JKI1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001977">
        <property type="protein sequence ID" value="CAJ1958399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF24">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="179"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="372" mass="40608" checksum="EC98CDFAA36C7BEA" modified="2024-05-29" version="1">MSTSTDECNPATKCGCDHNWHAYSGTTHFKSKATIVSIDSDSEGAPMTASEGAPPSPSLVTEGDSSAIEGASTEGNSSAIEGASTKQPDIQPRQVTFDDPNLAEGAKTFDPDIAMTRRKQLRLFILHERYGHLPYPKLQMMARAGMIPRELASVDPPKCPGCAYGKAHRKPWRNSKKQRKIKPATHSGQVVSVDQLISPTPGFVPTHRGTPTLARYVGATVFVDHFTDFTYVHLMTAMNAEETVLAKLAFERECATHGVSIRHYHADNGLFDTKAFRNSITKAGQGLTFCGVNAHHQNGKAERKIKEVTEGARTALIHAAHRWPDAIHAALWPAALKNYTNLKNSLPTKYTPEIKTACKPNIRTTNGRIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKW7</accession>
    <name>A0AAD2JKW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CST complex subunit CTC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1288" mass="143334" checksum="F5480F9A70B18665" modified="2024-05-29" version="1">MNPAASIAPLQGRISHRLELDHECSNVGVRSEKTSSSNKIKRWKVCGFVFLPSERDGTFPEFLLSLPYGIRRLACEATISKQTVVLTRYTFIHSIDARQAGIMPLLEVHSGGMQVNEASDRCRNQQKTMNPPHPDAFTLRQFRRYEAVFAKEMKDKDKRKNETYDIAATVDAISPIISMHPTFPFAFVELYDAQYPEETAILLLKSHDDFIYSYGIAPGETIIMCNLRRKSWSAPNDFRRDKKRRFEFLGGRIPSLVFITTASSKIESPQSGSIPPIPATTVPLVSLEGEIAHVETTSNRKMQKAIHWVMISGDGCESPGVKLFLTCFPMDTALQLSLQAGARIRAINVHKLCDRGLVSSDSANFGACLRATVSIIRMSSESKCQKERGSKGRVPYLRSKSDSDPSPPRLQKQAKQWNMSGTGSIWYPVPFQLKRIETSYHEYIYQDHVDEWLHENFCRDATSQLPALPSAIDLVGSAQRSAHVLKGQTHRSAIRNPYAEFFDHGDERLGPNNLGERCSGCIMSRHDYLDNFETMFLGLGKIKSACVESFMKEFDVSLRGGNMLGLPVVWSGSIHIQAHDIISSSGHSCVAGQMCTGGRVVETRSDGSTPASISDSWCQIPVLMKKESNCAKGDFITLKIEKAVVSCLCLRSPKGLALSKNDNISKALSPVKTAFFNNEQLGGGCTVVRHHGYMIIVAVHLVSSESLNFDSTQKEIDQESSQNDGRRETIASLLSDPLLFSDCHAGDYTSGIVLRHRFAPKKINPMGYSQCCELNVCSLTEEIHLQNLYLNGLSHLQSIDVKVSVLCPDSIRDRFKEAFACISGGVTLAEDECALGASWWTLADSGRTCALTSGGYDELQPNAPKHMHNQLGIRLRIPLSAMQLGGRGYVRCSVHSTEVEADFAPTMGTVDTPSDVSSENLAGNEPLSGFHFLGCRRVYDGILQRRPPRRLIFGPDSLRSVGSLLYPPQVPTVEVSTLFSQLCLSLRGKDTNHIPLAPSLVRQISHASFLGVLFCQVQCVCSKCFKPLEATRIDKHKKRRKEESLEEQSFWHLPHPNRSLELDVWNNETNLDRPFPIPQPKIAKHIRDSPLKCPSGHSSVSFEVRWECSGIVDDGTGQAKLYAERDAALTLLGMDAFTIKNIEEGIWSIPSGTIQFQKSVPPPEFLRAKVMHSVIQNRRCKRKNPLSLLEPSFRAEYLLHHHCRSSPQPRRPLDYFVRCKPLSDQIPHLHHTMVESSVVTRSVNGSREYALAIQDVATYSLPPLKLVLVDCAIPSDEDAMPPLTHDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLA4</accession>
    <name>A0AAD2JLA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS18967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="LysM" evidence="8">
        <location>
            <begin position="77"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="1093"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1356"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1960955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1402" mass="152878" checksum="C47B144AC5CDBBDA" modified="2024-05-29" version="1">MMSEGGVYPWKRQDVDIHRGPPASYAGLQNPLPEPPENMRWIKDEDTREWSLERKLEKDTFFQEITPKPRLENRNYFEHEIQPSDTFTGICLRYKVSAAQLRKANGGFSGTNLFLAPNPLKIPRQEMTKQKSGENEESSKMRASDSSSIGRTSPSQTEISQSVNGVSSQATTILSDDEDDDDDSNAAMQVLQDSLRFESERQNPLQFESARLPPPQPMEERRTSSTTTLYPPIESIEAIARNQIELEETWKAAAEPQKMSYQETKAAAAMKSCCDDCDGSSCTCASSNPHMSPTRHHQFPFMALSNPHAAARATSLRGPTLYPSIFPNGHNTPPRALARRSRGIDYDDMDDHHNRHGQLRDDDDDLLAMKMAAYEGGGGRESMPPVARMPSQQAEATVVDYDVHPADISVHAVQADLVGQEHYHGDSQYNSSQAQVTDYPPTTVTAHASEFIETAQSVIATVAGDATEATVIESGPMDKVTADAWDATTTEALVLEDSNMDIVDLDSKPPAVEDRSLPREQNIAYDAQEGHMQEAAAEATVLEFDDHPSTFPIASNAVHAEFVGQDFRSSSQDICSSAVYEHSSSADSDFPPGSNHEDVAIQSAEVRADEMNNATEATVINSSQLNEAWDVVSAVEETSGTDVVFPSGEAEVVGITEDVHPSELACSVNRAELVGTDLNCAIAVASDHQHEESYDNNFDTQVEEAQVLDDAPGDTTFEPELKDVPMQDNDWTSRDGSGDSFAIAEGAAEVVGITDNYHPSELVGDAAQAELMGTDSNYAVAVASNMQQEGNAAQGLNDATIGDGEFVVEGPVGDVVATETAGQTGAVPRETHATFIDYQEFTQVDAYAAVMAELVGDDNRFSNEEPPMPVTVLSEPVENFDYSDGSALHARKTEVPIANQNSAVIETSAVHQEIALDSDHHYTQGNLSASSHNSPSHVVASPMLTNSAPAAEAIHGSVDADAGVDSIAIASQRTTSSGSIRLQSFHPSSIARNTSNVMARSTSSVIDLLFRCQNVTTNDELARSLYPRELLPSTVLFSEATNSWVTTVNTNQKALEQRDTEESAKSVRAFSVPTRKQAVCLAKAWSPPKMHAFEANPACTICASQFNVFKRASHCRNCGICVCNNCMVQWPQKMLPITYNIKKESMMNVCKTCDWLCSSFRLALLDGDKDRAIAIHSTGNINLTTPFANVKGELFYPVHCAVLGGNLELLKWLIEEHCCPLRSIRISSCRQRDAAGTYTPILTSKGRSLLGIALENRNIDIVHYLVVKKRMMLTAEKGISNEILTQNLDLVLRVLPDNAFHRQQTSLPEDLAIPIDSTIVRSSSGNQGIQTEDDNVITATSLSDVGEEIGTSRDECIICFSNPINCVATPCGHQICCLDCSRNIIRCPVCAVECTFMRVYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM21</accession>
    <name>A0AAD2JM21_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS20164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM21"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000002">
        <property type="entry name" value="Serine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="entry name" value="serine acetyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010493">
        <property type="entry name" value="Ser_AcTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053376">
        <property type="entry name" value="Serine_acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041874">
        <property type="entry name" value="EPS_EpsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42811">
        <property type="entry name" value="SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06426">
        <property type="entry name" value="SATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00971">
        <property type="entry name" value="SATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042023406" description="serine O-acetyltransferase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Serine acetyltransferase N-terminal" evidence="9">
        <location>
            <begin position="282"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1963442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="550" mass="60423" checksum="FB27021BABBAE7EC" modified="2024-05-29" version="1">MRHLNLNRRQAWKVLLVAFLSALQVEGWSPSNQNHGVSSFSSFLAPSVRKSIHPYLHSRQRTRSPYAVPLFSSASPAVNWEGNQTIQISNSNSNLSPAEDDQSKSETTTGDHANTPKTSGYDLGIGKNLPVGSDQVNTEEDADDKLHWYAPEPIRKPGMMMKQKNMEKTTNEEPTVSSSKTPSVDRRNRKGRTTRKMVARREEDQILRGALWHEDHFDDNPQAPNEHYVVAGEVKPTQGGVQDDTTTNHEEDENSPRQPALFYPDIDLSIPESVYSNSTDVVWDLMRWEAYQEAQREPLLVSFLYSSILNHDSLESSLAFLLANKISSPAMISTQVQSLVKEALQLDPSVGRVIRADIMAVRDRDPACTCLPDVFLYFKGFQALQTYRVANILWAKKGKTVLAHYLQSQMSQTFQIDIHPNATLGSGIMLDHGTGIVIGETARVGHNCSILHHVTLGGSGKKGVDRHPKIGQGVLLGAGASVIGNINIGDGCQVGAGTLVISDLPPHSVAVGVPAKIIGSFVDVTKQPSNVMNQMMDTGFTINPFQSEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMW8</accession>
    <name>A0AAD2JMW8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="123" mass="13560" checksum="BE688B802E0528BC" modified="2024-05-29" version="1">MTSTKVMDIPNEKATIHATVHPCTTSKQDAPLVESIILLHGGPPGVPEPFSELAAILTAKFQVIYFQQVVYSVYLFYSVLLFRFILDSSYLLYYCGESQPSEVSFFCGSSFFSGSSFFSGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNY1</accession>
    <name>A0AAD2JNY1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23065</name>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000824">
        <property type="protein sequence ID" value="CAJ1939646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1968056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="76" mass="8806" checksum="02E79EC206636810" modified="2024-05-29" version="1">MTTDMTILRRYSFLLDLESAKQNKTKQNNSAIVDTLSSSHPQQLRRCKCFQCHPYARRRAPPKLPMATTADHTDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPQ0</accession>
    <name>A0AAD2JPQ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002494">
        <property type="protein sequence ID" value="CAJ1970315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="447" mass="52367" checksum="C160A47582B3E4D2" modified="2024-05-29" version="1">MLDTTAVRRYLQLVHKGYEEYSISSRLASLHHQLQLNEGTMTAKMGRHYNCLHHQMYVVRRKAEEKCRRVTNVSVPWSPKMQQFWDRQSLWKILLKGRKGCRVSLRKIRRLMKKVEIPDAWTKTTTELEIALRQDRKEYLEAKTHYAVKWRKEFLTVQAAKSKKKQWRSRKARDRFLRLQRMKQREEARRRRRAQAKGSTGGLHAIQVEERLPSGEVGLRTVSERSQVEQGCMQENCARYDQTRSPHMTPPMDAPLYQMFNGHDAEQNSLALLEGRLPLPDGIDYPTRSFLSQCRFHKDHSTSLLEVSTEDHTYFWSRNPEHKGSEPHGLHNGHFKAGILSPMIAQCDALFRHIPLTTGFVPDNWRHLMNFAIEKKPGEFCLKKMRTIQLMNSESQANYKQLGRLAMTYGKDHHLIADGQCGSRKHHQAIDLALSKRLVWDLLILQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPS9</accession>
    <name>A0AAD2JPS9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24453</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002515">
        <property type="protein sequence ID" value="CAJ1970435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002515">
        <property type="protein sequence ID" value="CAJ1970437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPS9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="89" mass="9256" checksum="3592559D224D616F" modified="2024-05-29" version="1">MAKERAAYRESQGLPARQATGQAAQTQQVETQLAELQAKVALIRSNNVPATIPAKAATQISQVTMGTTGTTAMGGRNQQANNQQTSGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUC6</accession>
    <name>A0AAD2PUC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS12155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00317">
        <property type="entry name" value="cyclophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1949554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="197" mass="21842" checksum="FB0C94BBC9C8B688" modified="2024-05-29" version="1">MVTTVTFETSEGTFKAELFTEKMPITCGNLIDLINQKYYDGLYIHRIVPDYCIQFGCPNAINPHVYYGTLEEEGIGEGAGPPETSFKSCTGKKHTRDEYGNIEDELIKDFSNKEGTLSMANSGEPDTGGSQFFINVKDNPHLDWFNGSSESAHPVFGKIIEGYDTIVKKIEHAEISETNSEQPAKPIQMKSVTVTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV06</accession>
    <name>A0AAD2PV06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="54512" checksum="11AA7A1D60B41C55" modified="2024-05-29" version="1">MSRVPDLSDLDLQLEDVEDYTSEYPTGEADIRNSAENDVVKYRRGVVTAFIFENKKLVMIAGTALVVLIAIISIASGKGSAPAAVDDGHAPLILTDAAILDDPKTDDIKNELQKMYNNNDMDPIVLTGADGDNTPQRRALSWLSHDYEEDMDHATRMTRYALAVFYYSTNDVPTEETPEPKTWYEADKWLTKEHACEWQGIECNERLHVVEIDLSRNNLSGKIPKEITALDEHLTTLILSENFILMHEKDYDALMPLTNLETLLMDDNFLHGSNGLPTQFGSLVSMKKLKLSYNLFKGNMDSAHSNAVLANMNQLTHLEMEACYLTGSMPHHIGRMSNLVYLYMRRNAMKFDLKFLTTGQMTDLFALWIDANEITGTIPSEIGLLESMASLSMTNSSLTGTIPSEMGNMSALRRLWLFNNELTGSVPVELKKLSDLEILQVHHNKLKGEMPNGVCENIHNSGSDVKSLTSDCGTNQISCSDSCCTRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWU8</accession>
    <name>A0AAD2PWU8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002119">
        <property type="protein sequence ID" value="CAJ1962779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWU8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="128" mass="14721" checksum="FA4C8548702767A4" modified="2024-05-29" version="1">MEWENGEITPEPLSIIGADDPVACAIYARDNNLLDTPGWKRFKSIAKREKKLLRMINQAKLRSFRTAPKYMYGYEIPKDYNDGLRLDKLHGNTKWADATKVEMDQLAEYKVFIDLGKGTPIPKGFQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWX3</accession>
    <name>A0AAD2PWX3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="487" mass="53672" checksum="2F9F2F15843763E7" modified="2024-05-29" version="1">MAAFMECVKLEQVDIPRSLEILGQFAFHRCFSLQEVNMEEGNLRVIGQKAFERCFKLHTISIPSTVESLERKTFKNCDSLRVMKFQNGLKSVADEAFYSCKNLQAVALPGSVESIGLNAFAKCPKLVSLELGDGSRGAAIQNGAFEECSSLTNICLSSESRTSPSSPEDHGERINSFRGCTALEAQYGETNISLALGNRFENLPVHKKCYHASVTTADELAREIESSAQSSPQGNPTHAHLNLVDPFGMTPFHILLSAANCRLDLLQVLVDAYPPHVLGWTDAKGKTAIDYYRQQGWNLNEDSRRILQLALDGWLVGSISSWNGLEVWKSDMSSRVNAIVAAEYDVEAWKSDMWSLVNGPAILAEGKVNERERQLLIEEAPLALLRYERMEATSLLELSLWKMEMKTATGASTDNATRTTSDKDEREAYRIRCGASVLIPNVTTFLCETSLNETNRTKLIGLVIPGNPASIVTPVAGSNKSIVTEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX42</accession>
    <name>A0AAD2PX42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002175">
        <property type="protein sequence ID" value="CAJ1964169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="107" mass="12337" checksum="17746C05105228CF" modified="2024-05-29" version="1">MKQGTNKNLMHFKEQFLRQAEVLQDPYGIAWFQNFEGTTKDLIYFKEQFLRQAEVLQDLYGIAWFQNFAVKTKAYAAIASTSTAAKDKFMDDIFKAVLATGFLCNCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXM4</accession>
    <name>A0AAD2PXM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290:SF6">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="343" mass="38164" checksum="7E4417A188B301D2" modified="2024-05-29" version="1">MNSIASSVSRRPDVLVAGLATAVYLQRQTTNPAEKRVLCEAPGASADPSEQWKAPTKPPSWIRKEVLARIGVPLPIPRVLTPADSALKLPKWCIARRNKDEEKVIALLNTAPTLKGDPEKIQKLGEQIFEVTYGKGVTPQIREDFLIKYGCTGWTDEVLSTIIDKCQTRGIVELGAGHGQWARALTEAYAERIQTTGKETKRIDFVLAYDDMSSLPLNTHIYNQYTQPHHDHFGDVKKLESRTDTTKVLRSWACRGRALLLVYPSPGDMALSIVQEYVNVGPENDTIIYIGEGRGGANGSEVFFDYLESGAWVLSKVLNVKSPPGNKGYEKVYILQRRKSDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXR4</accession>
    <name>A0AAD2PXR4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002330">
        <property type="protein sequence ID" value="CAJ1967486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXR4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="448" mass="52195" checksum="3D3826873E230D19" modified="2024-05-29" version="1">MASTHMLRQTIIVNEGDSPLAYKAREVTNPVMQYVSFFDNNFERKRKVEVWNGASGKNVEPLLRSIQSFCNISSEWGLNQGRQKKALFKQFLTAEPHMTYQRISDAHGNSVQDFEDSVDEFICEYTGENPKYQANMYLFDTSNHIRKPYNTEIGIHANCLKTLFMYHDMLPGNCSNVNDENDPGQIRKRKLALFRSFPIDWQGDFINSRNDPANDDNITWKDIVSWMTQKKRTVDRKRLMQESSPRRTRPGNRTGGRGLHHNRFRGGRGHGRPSNGYQPYPRPSSSPRYSQGTSQSFQRGGNSHQQNQGRFQPRHPNNGGRGRGFNGQRSGRSQSGRFQPGRNYQGRGQSHQQNSQNFYAESHYNQEAESFAAECSVPEWNQDGMSYGGMPSAEQYQHQEQYYQAEENQQWNDQYNYEQEEYYPEEQEAHEHFSYDEDSPFSFHEEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY05</accession>
    <name>A0AAD2PY05_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042284875" evidence="2">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="287" mass="33284" checksum="21C06B6A27FBD693" modified="2024-05-29" version="1">MMPLRLIVFLSFVSYIQASAISSATSYRRQSARNRTTRGAEATQQPCNGESTFQSPRKACKYYVWDLRSALLYRWCHHLLKDHVYEGRGGKKFVRFESNSILQLLYPCSRYAPNRCLVCGGSFSDHLELWWSKHLYTPWDLCMDRTYKEGEVIMEEDTTKSRRGRNKQTSPLIVSPPRYAFHKQYVQDVSDLMKGATTLQEQKKLLKDKLESSRKGDKKKALVQQRLTRFPEYGVAYLTPQKPKENPSRKGKRSSFTLEFARALCLLRLEGLVADQEYENAVLKNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CA72</accession>
    <name>A0AAD2CA72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1896484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CA72"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="153"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1896484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="321" mass="35345" checksum="85EA1D0B31F3AC5B" modified="2024-05-29" version="1">MLWYHPLASAIVLSLNMVKNRIPLVNLPSDNDSSSEMMRQAARQVSEALETSGFLLVQSHYLSKDLQQDALVATKEILNDKDNSETILHPVDPKKYIMIQSADSIETLKAKDDQQKILKEYWDVMEKVKHQVLHCISLGLGLPPGYFSECHSKSNSCLRLLHYPPVPEESSSSLLDENISSPKIRCKAHSDYGSVTLLTSDGVGGLQAMIDGVWTDVPYVEGTIVVNIGSLLSDWTKGKLLSTLHRVVSNDKSSEPRTSIAFFADPDGDISASLGNNSSERAGMTVKEYIQYRAGGDNRGRVGVAFTSDETNRAEGESNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAX0</accession>
    <name>A0AAD2CAX0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1909604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007826">
        <property type="entry name" value="PSII_PsbM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03038">
        <property type="entry name" value="PS_II_psbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042203136" evidence="2">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1909604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="104" mass="10789" checksum="B195B33A1FA864BD" modified="2024-05-29" version="1">MKTFQIIALFCVISSAMAFAPVSMPEAAKIAAAAAPVAAFSAPAFAMDSIVEALPSTAVALEVQFGAYLAVLLGTFLPVLFLINLYISSETRKAGAADALKDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBT6</accession>
    <name>A0AAD2CBT6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS1227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="755"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="769"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1438"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1630"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1926554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1670" mass="186668" checksum="184CE3844977BF4D" modified="2024-05-29" version="1">MDDTTQEVQEMTSKGNQDHDESTIKEEEESSSSSSSSESYESEEESEESEESSSERDDESPNKDDEQEIDEFVEFVYRSEDQEITETIKQTMTKLIVRGPNVKTIGKEAFRECEKLREIDFTEATALETIGEQAFAYCPSLLAFKCPSNVTTIGESAFDRSEKLKEIDFTEATALETIGVGSFFKCASLLAFKCPSNVNTIGAWAFGECENLKEIDITEATAALETIGNNAFSDCPSLYFEFVYEREDQDIPLAIKQTMTKLIVRGPNVKTIKEKAFENCEKLREIDFTEATSLETIGEQAFSACPSLLAFKCPSNLKTIELAAFASCQNLKEIDFTKATALEKIGDAAFAHCPSLAGSFKCPSNVKTIGTFAFADCEKLKETDFTEAAALENIGIGAFNNCLSLEFVYESEDQVIPETIKQTMTKLIVRGPHVNTIGQEAFSGCEKLKEIDFTEATALKTIGVRAFAYCPSLLAFKCPSHVKTIGLYAFVGCQNLKKIDSTESTALEKIGFSAFFSCPSLEKVYLAPNVTVVEKDVLKECPNLKCLKIPSVNPAIRIRLYTQLGKDQKHLINWDATVNVYASNPIKSSELLENSGEEALILQQVRANYIGSIVDGSRRLLSISERNGWLQFLANNVGDGNNDPDMSKLIYHLKTTEDIGKVRQLAETKDQSERVAKSVASKHIQAVFQARLFFLGRYDIARGPPIHQSATCVVVKATDAKMRDYFEKKYEPYEGKEVDKKLFKEILSMIELIPHDKENINHLFQRADVEKDKKISKEEFVNFCLAEIGGTVVLKFMRNKDQFRREVDSRKDNKLDSKYVVGSIRSHDEESDANLVQSLKDSILQEDGNGTSSFLKKDGAKAEDYCNVLVMPYGDRNLDTIFRSERLDILTIQTLAKEIGEAVAHIHEKGLIHGDLKMLNVVRINGHMVLIDMDASAKIGEDFAGEKYSSGVIPPEMIYQLANHKEKEQYISYFQDQNEEEQQKRAPKFSRIPTIQGYAVKSFLGHDETTTFEDRQTGNMVPKTKRMVTSKGNLPMFELVGADKSFDVWSFGVLLYTMCSKEPLFRVNTDDDITDGNSMRELFHWGQDDVEVDSILENSIQDDAAKKLLKQILKRNPKDRPPMKKILLDPFFTGKTTDELTEVVKEEFRKTQSLVLENRQIMQHGFSKIHESLKLVLSHQKAANNLLKGIFQGKNNSQPKYLIILPAFEQDNQEKRFSRFLSTMKETVKVKTKARLCFICPVSLQPVLGKDGKAIGYDIELAKDWVKKYGPAILIGLKIVQVGLAVGRGFGLPLPSLSGAEEGLKETSNLFSEMQGLLVEGIGGDAEEDGLADMMLEKFTDRIDSAASADGPGAMKKNHQDRIQKSYEGIGTLIKDEKFERCGLVQAISSNGKEYEYVHPAVEPLFEKFGSKCFEKSMEEREKENAILAAKAFSEKKKHAEKGSAATGGNGTTKRGTLASSVAAPQPGSGSPIKLMIEHHKGEVEMTADNGEIRAKSAISSSNADNVFIARLEDKLTKLEGKIDSTNVLKLQGIPEGSNRVVHKGWLRIRSRWPPYLWKERYVVVYKDGSITHYPNAGSSFSFVNWKYMEDGATMELRSAKEKVIATAKLSTRCSSKVAEWLQGNNWKFNNERSTTTTTTNSKNRKARIGPTGNVTNIDPLLADTYEYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFN5</accession>
    <name>A0AAD2CFN5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS2876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFN5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF7">
        <property type="entry name" value="PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1932517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="307" mass="34046" checksum="0E5B2CC181BB08B5" modified="2024-05-29" version="1">MKAFSLSPGGLLLPYHLGALQSLMESGALQPTSDIVGGSSAGSIAAMSYGCGLKPTDILEATIKVSDQCHDLKRARGNLLPLLRHEMETRVGPEEFDFLMTSAEEGGGGRRIGIAYKEIFPQRKSYLQCDFESRQDLFQSVSYSCMFPFFATNYPCMMDSSSFPPRLMVDGFFSVPRARFGCPDFEPYLGDPKGQEQEDDGGTVVNGKENNKKPDRTIAISVFPKDMIGMEAFSDDNCISPSIITEEDSNQLSVTDMFRIATQASSREELTQVYEMGARDAEAWCRREEQRKSRVDHTEATIKLDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFW7</accession>
    <name>A0AAD2CFW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS3283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000269">
        <property type="protein sequence ID" value="CAJ1933386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFW7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="244"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1933386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="746" mass="81470" checksum="6E38C6E5225018C2" modified="2024-05-29" version="1">MEDELDAAQLRQTSDLNKNLRAGAGEGSLLHLYESRLRRLKQYEEIVYSRYHGAIPGELEEDFFQGPNPADNLNAKEEEEQKPSAEPSRIESLSKNNAAAGPPSVINIDDLETGTYEDISVSTGLNSLLTSSIIEPKSEMAQEEQDGFHDDRGGESQGTIHNSGIHPSGHNSNNTFHVSRREPSKEEEEDNNGSDENDTINRAYTYQASSDSKFEEYSCLIDPKRDDRAVEIMLYSAKRPHMRAFHLSWLGFFAAFFNWFGIAPLMSQVAHSLRINRTQVWTANTMAVVGSFITRVMAGPLNDIYGSRVVISVSLLISAVPAILSGVLIHGAVSLYIVRFLVGIAGCVFVTCQFWTASMFTTEVAGTALSLTAGWGNLGGGFSHLVMGSLLFPLFNLLYGGDGYKEVQSSVFPNDTNFETNKPSDRAWRTILAIPGILSLVVAYLSFKHADDTPKGNLGKRKKLGLITQESVSKALGRAANDKNTWLMFFQYGCCFGVELTMTSAASLYFQEEFGQSTASAAAIASVFGWMNLFARGLGGFCSDMASARYGMRGRLWVQMFTLFCQGGLVCVFSVTSTLTSAIAVMALFSIFVQAAEGSSFAIVPYINHDVTGSISGIVGAGGNFGAIAFSLIFRQTQNRTAFFYMGCAVVASSLLCAFVTIDGHRSLFFGEDATEVKERRSAHAGQLGKLPTVDFRNSEMQKRRNIMAESSVEEESRRTFDNDDIISVHGASFDDVVSGTEVANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGF5</accession>
    <name>A0AAD2CGF5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000202">
        <property type="protein sequence ID" value="CAJ1932085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041960226" evidence="2">
        <location>
            <begin position="17"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="664" mass="73217" checksum="4242B911BCA38852" modified="2024-05-29" version="1">MKVVQVLAVLFYMALGSSIATDAKHHHGERASVEGEQSHLRTKQQHGRHEHSEARDASSKNVVKTETHKTQQERFFDEDGFCGDTCEFCDAFGSLATATQKLQSKVAYPISLVLPFTSFASNVTTFRYEMAEKLLPIKHTLETIEVVVDNILPLVSAEPYIGTLMKTISVKLDILGLKLDVIVNDIPTLERNKNATTFLHNGLSTAKETIEYANIISSAANTTIGLVRTVGCSGCHQELTMSAVNVEKIEALSEKMYGMMDHFNLPAIPFELPKFDFNLDFLDEVKEKFSKFQDSMQDILDRTKKDIQTNYDFHKCCTPNVHYIATIGEVFSDMKDLITCVPNTGITGVIMAALNPLLKQVDMLFVDFNAAIAKLNVFGNQIVDLMNNVQVVPKFMNDISQIIDKSAALIAWNSSDSLAAWNALNASAAFNALNALVVFNSTTCNVGFADDIFSLSSICGEQRCTFPAIQPITFANKAAEPLSAIWESMQKECNRAWDDLKDIEEQTPCCEASRIALGAPPMGYPHGHSCAMSKTYICAYPHVCLGGAPGITSGTCQSGQVGSYCGRDVDCLDDAKCVLGSCRAGKVDDRCEFDSDCIDNKCVQLFCRSGKDGAKCELNSDCDSDRCEWWGHVGYCKAKLGYGSYCNEHADCQSNYCSWRFRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGW0</accession>
    <name>A0AAD2CGW0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGW0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="292" mass="33412" checksum="A844E500A4A575B6" modified="2024-05-29" version="1">MAPLMREEQQQESQQPQEQLASDRFSNCSNDSDSSPSSSHRRVRIRFNHTPQVETIESKDDFTPSELSASWYSGEEKRAMYEDYEKIVMRMEAGRRPKKNTTYRGLENFSETNSAQLDEIVHACIDAVMDDQDRQWAENGNEADWDSFREVSLQVSLQSASLAYKMAEYDEREARKAYIAMAKEEFERQQGKEVQQDDASVGTEVTEVTTSTMAQDVKSNHHKIVSPLKLGGRSKKSSKATNKNGKNRPPKARSSGSRKTLGDALENLNKKKAVYNDKLRDREFQPKVLRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH30</accession>
    <name>A0AAD2CH30_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH30"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="871"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1045" mass="114749" checksum="189AB8F08AB0841B" modified="2024-05-29" version="1">MGLRFADEPTTIEFEKMTWEEMDEVFYTDDEIGDFRYSAFMINCGLEEEDWAVPDVEPTPWNKEVDEIRIKNFATNLSELKEHQLKAKKEHQMAEMMPRKVVSPTNTASSSTFSGDDSEEAEDEPEPEEMEPEKEDEPSSSEKPETEGDKIENDDSKAEAAMDKLPPAPPPAELTSPGTPRKRPSALMSPRRSRNSKANLYSPEATTKPKVSAMVNAINLEPEEKAEEPPSAPSTPGTPRKRPSALMSPRRSRNSKANLYSPEPATTTKAAVSVTNVDAISLQPCSREEEKEDEPPSAPSTPGTPRKRPSALMSPRRSRNSKANLYSPEPATTTKPTVSTKPALSTINLEPSPEEEPSEATEIEEPVTEQDKMKEDEEEMEPQTADDDSKQDHVLKKKKKKKNSDAGLDTSSHSVVSTASTIESLDMTPPSSSNDADKKSPLEDVINTIASPETSQKKNLNNKNNNNESSTSSIFSGNRTPETKRSKFAVSNLGSSVHVESTSQRTRPTLKKTTSADLEHMKTTAGAANTNYEKSERSERKLMRTHSGSVSRGKRRKTKKKKTSSSSNDDDDDEDETSSPRKPARRLKKGDKAHSISSFPTAAMESPAGKPKKKKTRNSVSSTKPSTNVRELPASPKHPASPRQVRASSLKNMISPDTSSTAGRSKSPDRSKSPRRAKSPGRSKSPGRAKSPGRRSKSPKIKRSSLLNSDNGASDETDSPKPKKMSSFKRPSSLRSNASEASPKKSKKRSSFKRPSSLKLSEKSRDDAPETPQRKPRKGMKREESLKLKSDPDGTGHSTIGTTAKGDNDDGKPSSKSKSKSKNNMDGSTSEMTAEVDDENDEKPKSSSSLGSFKRSSLIGATKKTTKRFSKSISSRSQSMLSTITNKFKPGSNSKSDGQKKQPEVQHISSDPSAFAFNALPAELKQKVAFFLPIGDVMNLIATSKSMRSEMNVDVISSPLTDSDSQNKVYRTGMGTKCIVAVLPNSEASLHTMRFTCDVRVGLRPFGRVWVVEQNLPVKQDPENLESLGCINFMLGLEFTYTWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH37</accession>
    <name>A0AAD2CH37_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS3878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="9">
        <location>
            <begin position="45"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1934538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="283" mass="31773" checksum="25876C4969C88043" modified="2024-05-29" version="1">MMSNANKNLLPTQAASAPAVPPSGMKKERRRAKRKTSSSSSSKDEAPMFLRKAFHIVNTCDPTVAAWSEDGYSFYVKDQDRFASEIIPKCFKHNHFSSFVRQLNFYGFRKLREDHVELDNVDESKSKWCHFRHPKFQRGRPDLLREISKNTHKEVAEKTELDALRAEVKDLKALVQTMKKDMGVLATLVGDLSHQTRLQTATSTTTSQPPLKKMRLEVEPLKPDIAKSAIPAVPVKPVAFGGERTASGLSAVTFNSEDEEFITSLFTEEGFDDTLDIPDAIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIV9</accession>
    <name>A0AAD2CIV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidylprolyl isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIV9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042081004" description="Peptidylprolyl isomerase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="46213" checksum="55A67C2A0BDDE317" modified="2024-05-29" version="1">MQFLLRSTSQCFRTILVLALSLGCVVQQSGGQQVGIDICSCAPSTYEFQFDFSLFCPPINITQGDAVVDTSCLVSPFQDQSVGDLVPIAVQEITVLELDQNLDNLYQEIIRGSFKDGDTWSYTSVAAQPGRTDPNSLPRGIQFNIVGINILEQPIINTVIITFSNSCQAYPVLIPGQYAGWVRFLELEDPLADYCPFTPDEPSAAPSPFTPGPTFPPTPPFMSMSMDLGMLDLLEDEFGLQRSDCTESSSSRYTKKSRAGKGGKGGSSPKGSKKMGKGGAGKGGSSGDLSSMMTDSSLKSDSSSKGKGGKGGKGSESGSRRLLRSKGSKRIGDCDGKGGKGGKATKKDGSSGKGESSSGKGESTSGKGGSTSGKGGSTSGKSGSSSGKSGKKDSKGSKKESKKNGKGGKGGKGSKSGKSYSGSGSSKGKDKLSKKESSESRRFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJA3</accession>
    <name>A0AAD2CJA3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000358">
        <property type="protein sequence ID" value="CAJ1934662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJA3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="212"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="42340" checksum="48994EA93B0E1D86" modified="2024-05-29" version="1">MSCFASHFAACQRILCHLAVNWTDWQHNIIKNAPKIEQQTHVPRRSGGYAISAKFVQRTSIQKAFEYSQGEIWDYGHRSGRRMDSTLLKRILNDVKDIIGHRVTYYLQFGHIPSRKKAWKRGPSKRSSFAANDDQCLERLIAEQPQLYFDEMVTEMKKLTGTTWHRATLWKRMYSRGYSLKVAVHRARQASEVEQAFFYQRLNEFVLDPRQILLIDKTHKSCNASRRRRAWGLRGTETVVPSFFEEDFLQQFTMIGVANIFGSLPEACEIVHRNENLENRGTVDTERFGQFVEQRLVPILGQYTEKEPNSVVIMDNASIHMSDQIEEMISAAGAMLLFTAPYSPHINPIEYFFSTYKKGLARNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJB1</accession>
    <name>A0AAD2CJB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000361">
        <property type="protein sequence ID" value="CAJ1934692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="153" mass="18228" checksum="29D9F96F520027C8" modified="2024-05-29" version="1">MYTVRRQAEEKCRALAPGKVPWSPKMQGFWDRMSLWKLLLKGKKGCRVSSRKVCRLMKKTELPQAWRKSAVDLEDCLKQERSLYKQAKHTYAAQWRKDFLTVQTKDAKKHQWKSRKACDRFFWFRQMKQREEARRRCRAQSKGSTGGLQAISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJG3</accession>
    <name>A0AAD2CJG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000381">
        <property type="protein sequence ID" value="CAJ1934783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJG3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23009" checksum="DBECFAF148378C2D" modified="2024-05-29" version="1">MARKSEGFHSTVAYNTHQPQAANSTTQFGGCSTSAFNDVSHRVRSSGADSLGQWAWIRLQGRTQGVGQRDLVVISAYRPNPPNDGQQTVWFQHEAHFSRTNRDTEPREAFIKDLLTAINKWRDDGCSIILGIDANDDLSSYSPKSFRFWMSEVGLIEAIQSKHPGSHQATYQRNLRGYPIDCIFATPDVPILAAGYYPFDEHVASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJV7</accession>
    <name>A0AAD2CJV7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000569">
        <property type="protein sequence ID" value="CAJ1936861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJV7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="111" mass="12668" checksum="CB4755E7BE9346CA" modified="2024-05-29" version="1">MCQPTILVPLSKGMTLLSLRKDDCRRGTQSQAQSHSGNAKWKKIGDTEEKKQIRCSVELLTLLRNDLVACILSDVKDKENEKKQQPKKKQSQTRPPTKKRRKLGHEESKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJV8</accession>
    <name>A0AAD2CJV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033749">
        <property type="term" value="F:histone H4R3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106140">
        <property type="term" value="F:P-TEFb complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF22">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041972615" description="JmjC domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="214"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1936277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="526" mass="60498" checksum="82B846D6CCD19FDC" modified="2024-05-29" version="1">MNGLHQGFTLQFLFLCLIGWAVARVGAASAIRVRDDEPSLEYKRVHNHLDTWKAYSRKKHTAAEMCLKPKTTSEPSFLIRPIRRVKASEMTVEEFNSKFVHADRALPIIFEDDNFDDSEWTPSSFIEQCGDIPIEDSEDEELGEIHSVREVYESLVGEKWAGLGVPDLDKHNIVTMEDLLNAQGTPEGKGLYLHDAPLSWHCPPKVDKIKVPKYFPRNYDALLWQPKDLGKTAVELEFQWPSIFISKAGTGSRLHSDSRMTRFYTQVLHGAKLWRVTPPSEYWRLDPQSNPETTFYPTIFGADIIEPDFEKHEHLDGTLVYETIMKKGDVLFLPHGWPHQVLNVKESVMSAVNYYDSTVLDVAKQCLEFEEYETNDLYVIKAFFMPLDDPVFNDGDPEQDISWSDFLRGQHLQVAEVPKWLIEKVKKEPHWMINYRDLDGFPALHVAVEYNFMKLVAFLIETAGVNVNFIDRLGSTALDLVRDMNYPEMEKLLLNHGALSAEQIRYKKAANQEPQAKSPSSSWWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK16</accession>
    <name>A0AAD2CK16_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="421" mass="47613" checksum="A05D566C7335F2A2" modified="2024-05-29" version="1">MHGYRVTTNYDWLPWNIDSSIPVPEDYTDMPLQPLGDKQAFYENHMQGCRESMKAKGRSCKSYENARIDRCVRQPRGVHNYTKIGYHKMRAPEGLFQIIKTFWETNKDKEVIETWDSGDIAVNHWESPTYRVPLEDTSMEGGGPILMQQVYDGIRDIMSEWTGQYQVPNSVYGIRIYKQGAVLAPHVDRLPLVSSAIINVDQDLDEPWPLEVIGHDGLATNITMEPGDLVLYESHSIIHGRQFPLKGSYMANLFIHFEPIGPIGTEVNPNLDLPIYIVKGSEIEIQWQLLNRGIVYNIFDNNRVPTSKIHEKARQGNTKGVTRILDQAHESVFFRDINGRTPLHEAVQSGNVNTISVILSHAKKEKGYINQRTKQLGKVGAGGSALYYAVKFHGFGHPMVELLKQNGAKSIPPESTLSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK18</accession>
    <name>A0AAD2CK18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK18"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="425"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="518" mass="60276" checksum="22B7E93D79BD11C7" modified="2024-05-29" version="1">MASSLPNSPFAKQACLPCFNNDDQAPKDKNTPHHFQMPRKNTNNDYITIKPAMKQTEELLASEMSQLSVEERSKAMDDLHCVGEEIQETPEMIQKSLAEFQEAVKKERNPIYEMAFNQNRAYVEDPTFRLRFLRAKLYNVREAVRKMMLLLECKAKFFGHDKVARDITLDDLSEEDKQLMLSGLYHIQDGRDQNGRLILHFFGKMLSRCRADNLIRIGHYIMYNIMSSLPDVQRKGIVVVYNDSTLPEETFTLPGFSFFKEIQTTYDSEPVRFSGIHYCVQAKSHHLALNNVLVSLFLKGTPQDGRARSRIHYGSIMELRYQLQSFGIPLSTIPFGEQGSIRNDILNVWFDRHLRETNQSIRFHHSEAAQGWSQDMEIGSERLNHQHRHYEKNENDAKEALVAEPWQNTAQTNRVSKLVKPTEMDVLFGKGYRLQLHPGNVRFREFLQQHRGEYESTPRQNRRDIAIKLTQMLRNSGVRFLQKAGSDEWVESDSEHAETKIAQFFRELRKKRSKLATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKL0</accession>
    <name>A0AAD2CKL0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS5576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000624">
        <property type="protein sequence ID" value="CAJ1937255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="294"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="603"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1090"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1214"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1090"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1216"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1241"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1937255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1283" mass="143966" checksum="B9E8976B91561CD1" modified="2024-05-29" version="1">MQNHHNHVIPQSQLQLQLQSNQPQSSNPASSAANHHHHHHHHYAHQQQAYASYATMRPALSYPNHPPPQHQYAGYNHNSYCNHQAPPMTFSQPPPPPQSSSSSSSSGTTPSHQVKPRKVTPPKAPPAASASRRSERKRKSTLVYVDGHAVLRQNNYEVKGGEYVHGHVYSNAPRPSKRTRVDRNHGNIMATKTPNTEPAPRVVSAHEVQRKHHNARVQAVVRQNEGLRWNFLGQHVDLLQHFCEPKVLADLKNKNSSNRENYSIYQPLDLLTEAPKAVQATLRDYQLQGLTFMANMHNQNLSMILGDEMGLGKTLQTISFLCWLKENRGVTGPSLVICPLSVLSSWCKEMAQWAPTLKFFRMHASSPTEQMHQKHELTTNACHYDVILTTYEMAKVPLMRSFYSRLHFNYLVLDEGHKIKGHETQIAQAVRSIHAGNQLILTGTPLQNNMVELWSLLQFLYPAIFTTSEPFAKAFCLAENVIDKGFLQQSHQLLNLFMLRRLKQKVETFIPAKLETKVYCPLSKTQSFWYRSLLMKDLSKLASAEDQGSDALEGNAQKHTVLKSLFMQLRKCCNHPFVFDGAEMDPGQTTLEELVAASGKLSVLDMLLQRLFRDNHRAVVFSQFTSILDIIEDYCRLRGWKYCRLDGSTERARRSYYINRFNEPDSPFFLFLVSTRSGGMGLNLQTADTCILFDSDWNPQSDIQAMGRVHRIGQTKTVHVYRLVSSGTVEERMLQRAEKKLLLEMVNQESKESGEDERVRGLSAAELLEDIKFGSQAVFGDSANNELPSWQDIDTITDRERKESDSVGKLHGNKQHSAKEFDAEKAFGETQTFGGIDFRAVRKQQEDLLKSKIPQNLKGIGNLWQEISQLKSKRERKNRIMMVESNGSGYGKPVPVLKSNDYDLENGESSVFDRELKKDRKAKFKVAKKKVEGPTFDNQDFCQVCGDGGSLVCCGRCPCSVHLKCVGLKRAKDFLACTHHRCTGCGKNRQCAGGLLYPCQACPNAYCEDCLPKNGVTYLENVPRFDALKFDSANSPVVYIICSNQCRAVAKQEFGYVQKPSNGGKRKCLRPLDVSFGFGATKSLEAELSELQKEQKEQETGTNSTSEKVRRGGRIPSKIESLPQIKKNPDSNSCEEYRRWKALPISERAIEKVCLSTGKVLDVCANFKDAFKNSRLSPTTLYDRLRKQSPSECDGFLWKLTTVCEAGEQSVAKGNDSCATTASSSISSDSTSSDGKLSPPNEETSSMNLNEAQPKSPATSLPNEETVSMDEAQPDPAATCACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKX6</accession>
    <name>A0AAD2CKX6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS5000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000535">
        <property type="protein sequence ID" value="CAJ1936009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051084">
        <property type="entry name" value="H+-coupled_symporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="111"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1936009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="583" mass="62836" checksum="8B742393F6C2C0BE" modified="2024-05-29" version="1">MSSPSSWPSKYCSRPTTSTAATTTKKNYGSTTRTTTKDVATATATATATATTTTTTTTSSSTQQEQHHHEEQQHHEHSSYSSSSSSPGSSLHSNPTKKSSSSSSSMHETIKTLAGVAGNVLEWYDFAVFGYFSDILGKVFFPPHQAENVALMEAFAVFGGAFVMRPLGGILMGHLGDLYGSKTALQGSIFLMAVPTFAMGCLPTYAQVGAWSYTLLILVRLLQGLSVGGQLMSSLVFTLEGKPKKHWGLYGSYVMATANFGTLLGGLVGYLIRSNLTEEQLLQYGWRIPFLSGILVSVCGLYLKFYCDGDDEDDATFHHHAATTKRTSPLRLALRPESRRQLLAACLVPMLYSGGFYLCFVWMAIFMADLIPSDPFTTQQAFGINSLSLFVSVCLLFPVAGILSDWYGRRTIMTIGGILSGLGAPFLIMGIAQGYPTMTFASQSILGVSLSFWGAPMMAWLVESFPPENRLTSAAVGYNIGQACVGGVTPALATFLVDRYDDGGGYYLFSTGGVTGFLITALAMISLLGLWVISPQPSLVQLMPLLLPVKNNVDCLKEENSRLLQSMETAETLDSCSSAWPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKY5</accession>
    <name>A0AAD2CKY5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000413">
        <property type="protein sequence ID" value="CAJ1934918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKY5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="16928" checksum="03CC420B4D75E162" modified="2024-05-29" version="1">MQTTKSARFGITLYYVICPEEAPVDPAPPLKGKKAFAEVYGSHWDEQQLRASHLHSSFKTDDKTLFQKLDEALRSMNYVSCMEPFQQAKGQGQKAFFALIKTYLGDDKWLSEFTKYDNMMHNARVERSLQPDFGWQSSPSCRHPANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL19</accession>
    <name>A0AAD2CL19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1910601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1910601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="547" mass="61345" checksum="C6C9970345273AB7" modified="2024-05-29" version="1">MEGRPTMKGLTDGMSSRYLRGNRRLLIPELENLKQSGNHKSARSMHGRLEELLVFEIRKDGGTDYHTFSVRTLHRYILRAITKSDNTNDDSFNEALGQAILTPSPIVVDKRTKETKRSPETPSSENSSTKYESAEEEDDDAATEGKVRDVTYRDFLGGFLHPRDLRKLVTPFSASNAQEFIVRRHVILLHFDSLRAIILRDRVLLLVPDGADSIVEQLEKNILEGVDTLDATNENTAAMQDRQTLDEPPDEDDQGGDTLEPVTLHHSNLGSANKNDEVVGENNSESSDSDIVEEMNDQDLRESMRQDEWAELEGGAWVQWPFELHSVDAIMNRVSSILAEDVMDLQLSADKMILELLAPGADVGERAQEILRTIKNLVKEMMSRVTGFRRALENVLEDYQEMALMNLSRLLTHPDRFIQPVLPATLDEESGEPELILEAHLQHAYTLANALNLVQGQVNTTEEFVIRKSDGIRNRLLYINMLVSLLSLAVGGASFVGSMYGMNVPNPMEDDESAFEFLASITIGGSLTFVVIVFIILRMVRVLPPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL34</accession>
    <name>A0AAD2CL34_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041957006" evidence="1">
        <location>
            <begin position="20"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="298" mass="34155" checksum="BD882F4BA90FBF28" modified="2024-05-29" version="1">MSRLISLIAIVALFQSAFAARFLHFASPLQSLTLPDAEVKETLQTKRQGFLSKYRAGLQAEADKRRELAAKRTKDLQDAATSGDNWAENIKSRQLSRRALEEKLVDEAHDKAVAQVKGLKPAGRSSNKYQFVGVVNRKGDKPITWFARPKPEDSKWSVRLVHVNRDAVIKDLYNRGKVDIFAKYKNTGKIDEETKAPIVTSTYDVKERSWRNLWNFSPKHVFTDPSGMYWRERRLRPGLYTDGLSVYESSYRYSDGRNGMRRVSGFQQFIASKAVKDEQKQKILKKLKEAEPDVVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMK3</accession>
    <name>A0AAD2CMK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044999">
        <property type="entry name" value="CbbY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896:SF4">
        <property type="entry name" value="OS08G0485900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896">
        <property type="entry name" value="XYLULOSE-1,5-BISPHOSPHATE (XUBP) PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042142675" evidence="1">
        <location>
            <begin position="17"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="307" mass="34001" checksum="3906C6D509566561" modified="2024-05-29" version="1">MNSLIICFISVALARAFTPMNVFRKSTSRLQASNYDFALLFDCDGVILETEELHRLAYNKAFKDFDLTIDDEAVEWSVEYYDVLQNSIGGGKPKMFFHFKQTMGGKFPMSDDKPAPETPEEQQELIDSLQDQKTAIYQSLVEEKAIPRPGVVQLMDEALNDPKIAVGVCSASTKEAALKVLAVTLGEERQKKLDVCILGDDVNEKKPSPMIYNEARERIGIESDRCVVIEDSMVGLRAAKAAGMKCVVTYTASTENEDFYAAGCDAKIPDLLSRKVGLDSIFSSLREDGLDSELLVGIRDPKPSESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN71</accession>
    <name>A0AAD2CN71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RelA/SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="70846" checksum="E9516BFA4E1F0D54" modified="2024-05-29" version="1">MVMPSICERINVDINDPTFWPNDDDYDLTSDGGRAQNEWDKFKKVDSLLQTVNAYMDIYRKLLKSEGNRLRIIGSFPDPATKPPPPRHEIPKESKSNWAHLSTDDRMKVVLEAGNETSKELQKLGDELSTDLQGIKFKNGPLKEKDRATEKVKDDYDGDVLRVIDLARCSIFLESNSFEQANAVVDRLKSDIGLAKEWEIVRIKDGFEKAENYILGGYRDIKLNIRYKTNGHIAELQLHLKEYYDIKENGGHDDYKFARQQHISGITRATQLLDGNLLWPVIKLAWKELGTEQVAEKRARIARHLGDLTMMKGFVCADFFGKHSHLKGHIRKQVLEFYYASLQEIPAPDCNESPGLTALRIELLVWFVHGQHIQGDPIIDQVKADYPYPFHNIEAYASEQLGPLHPVTLHVMSTMNSIKNSYSLQKDIVNDLKTILGKKHNDTVQAMVKLGQIAYIGTSDEEKTESVEIMLDCLPALIETYGLQHDLIKMLAYQFGVLIVASPWLEVVQSDTIKDALRELIPDDPSKLNHRLKFVHLYIYGSWHQHMNLCVDVARTLVRPQIQEEVDFGIAAARGIVYYMKHNVWKPNGGAVSRVVTHIKPGTFDEIDEIVQMFREEGMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNP4</accession>
    <name>A0AAD2CNP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000946">
        <property type="protein sequence ID" value="CAJ1940721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNP4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="459"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="724" mass="79186" checksum="7756A13C87037C5E" modified="2024-05-29" version="1">MAYHSDQYALDATPLLNECIETLQVAINQDLLGNGKPLHKLKDVLVSAEDILHRHLRFLLEREPKQLVNGDSKFLSGSENIMDTLSALEHLLEEKRRQAKLSTPLLSGSHPQDPLAHGHYSSRSATGTMMFQLIVALQLCLLRLSDYVMTGDHLPSGRNSGGQFVFRGAWILCSGIAASIAVSRPERRGPIVAKLKTKETVLALGGLVFCKLIHSKVKALYIRDKIWKSTVEIEEWIRQWEAVRPRDEEEHEENFQQESMYIDHQSRRLIEYAAQRAPSSSTWQYSEGEIRFLMLKRFMDVYYASVSTAIDTKSTSYWQLPLVTGAAASFYSLTGASRKATEAVTSSSHDLIQHAWGMVSIPAVKGLMSQASKFIKGASVVDRITICGVSCFVLSREPAPELGAAIRKQRGGHQSALASKLSTIEEAEESVHEEAKSASPTNKKFAGSCGSFRQRDIIFHLTGGGFFSHIIGSDLPYLLDWSASTGAVVICPEYALLPKHAFPVALNQIAAVYSTLVNGNAAAELGFEVNRIVVTGESTGGNLAAALCVKIIEAGLRSEEKSFSESTGVELPRLPDSMMLSCAALNLSLEISYSRVIGKEDPVLPSGLIAAISDAYLPKGADKTQPLASPIFASDTVLRLFPPVMLFAGSTDPLLDDSVVFNGRLRSLGVQSELRAVRNVPHAYWGLGTAGFPEALQVQQECQAWLSRAFRDSSNAYNNMSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNR5</accession>
    <name>A0AAD2CNR5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000968">
        <property type="protein sequence ID" value="CAJ1940855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="232" mass="25848" checksum="E2C73748F365B043" modified="2024-05-29" version="1">MPSSSYINALVRSLYNESQETNVVMLSGSQPKIRSPHAFDLQSEPPSLFTRSANTWGGQFNPDHFQRIAFAMMSASPVNVENAAFAAMTATSHHKYEKNEKRSDRINKKLYWVNGSHVDETITYNQYTINTAVIAPTTETPEIKQAILQQSVNSINQTKTTMEHKVDFLMKRYTSVCPDIRSRVNTASKLFDMTSDVYEFASFHVINNSGQAIATGPGPGLPAPLRAAATYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPP2</accession>
    <name>A0AAD2CPP2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">subtilisin</fullName>
            <ecNumber evidence="6">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS7626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040001059">
        <property type="protein sequence ID" value="CAJ1941693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="126"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1941693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="421" mass="45867" checksum="228FB6C5C870FAC4" modified="2024-05-29" version="1" fragment="single">MDNNVKGEDEGSFDSDNIFEDLSDKGNHVKEILTSDPNKWTDEQITIVVVVSIVALALILMILWCYRYQPCRRKAVGSLVNPRHTLERPYVTRRGARMGNPNADDKLPQGCTLHGAEKLHAAGLDGRGVRVAVIDTGIDKQHPCLEGRVVRQEWYRLGTPLAIDDHGTHVAGTIHFMAPKANIYDYRVIGKTGDMDSDTAVAEAIRDAVQEGCQIINISIRISYPLVKDVKKAVQYAHREGIIMVCATGNYPGDADPNINHRLTYPAKWKETISVAAIKKGPGGTPVASFSDVLAGFGGLGFPADLAAVGADVVSLKPGGGYQVMSGPSVAAPHVTGMLAAMMTGGGDLKMLAKKLVLELKSTYSLEFTAKGSDNNGTDIDFPTFLTKWEFDKFWRRHSIGHANIHERPSIRKICNNYGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPP4</accession>
    <name>A0AAD2CPP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPP4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="8"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="322" mass="34511" checksum="609974A5D2E385F3" modified="2024-05-29" version="1">MKAISFVDTKPQVVETGKPTLKEDEVLVMVHYSALDTALDPVIKKTFVGGMLHKQTDPLFCGWHFSGVVEAVGANVGDFETGMQVFGNLPYASSTTQGSLSEYITVKSDALAVKPSTMSMDLAAAATTEPLTALQSLRDIGKLPKGGHVLINGAGGQVGSCAVQIAKALGSEVTAIVSTKDVAKVTNLGATTVIDRKKTPNVMGQLKAEQFDVIFDTPGKLSARKITKYLKRKGVYVNPSPDDMLDFLLGKLFTLFSSKSVKMVMVESKKADLEQIGEWTSNSNLKIDIDSVHDVRDCASAIHRQNDSSKNGRVVIKVKGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPT7</accession>
    <name>A0AAD2CPT7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPT7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="44983" checksum="AC8E227451E2535B" modified="2024-05-29" version="1">MVADSSSSPSIPFWGSSMATAMKSSIQNSSSTGGGASTDRVLGAAASLGLCLAILRVVGFSYTASRHLENGESKDKPSSPSKSSSATISHFLLSYVRHFLKKMLLEDDVDSFDDNFDDNLHPNRSSSITHAGSCHCGCVVFEVVAPRRLQARDGVGKIQYRHTKAKTSDFQVFKGQKYLKTYYIRSDSSYDRDRGAHAFCQQCGVHILYAPWKNSPHIFINVNCLGQGVRKVKSREEIDSIIDAVPADMDNQSTVSTVSGDSRWNLFLQHHDSSNSTLHDDVSISDYSYTRKPHQVSISQSLTAQTEMSSASSMTRIGSDDSTVRSYKSAKTTGSISLQPLHVPISTQHVSPAEQNLSPAMRDQMKKYMSRHLGGEKKTGGDRAKTIQTMKKQTIHSVSRAAVGEHNKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQS7</accession>
    <name>A0AAD2CQS7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000302">
        <property type="protein sequence ID" value="CAJ1933814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQS7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="55932" checksum="167672BA106F2023" modified="2024-05-29" version="1">MLISQDFFDDTLVESQELFEYSDEQAVIETINELKTSNPSVLLDHLSLTHPESQEGIDSRKKQKDFVECVRREDVSGAISMLATAIETERKTMPTYASLVLQNRLLAPDSKILLMFEQDEEELDTVLKFAAAILPDVTTNHPSAKELKLQFGKPLEESWCCSFEKYPSLSTPLVKWARICCNVCESNKKTFVRSAIEYRSKGGRSGLKLLLDSLPKEVPTDQNQQASAVELIIEVCKLINIVCKFQASAEAQPKDGETPTVSSAHANVKEFHKTGAVNVLHLLARKCTGGDREDLLCALLSALRVLAIDNDIVQNMVAVGLLDTANASLLSNETISAPLAAATLGLLRNLCANDEIKTTVCKKSLPSILHAMETHSSNPLVQEHGLGIIASMALRQPNNANAICEAGGAQFILSAMRMFPTKVPLQRQGALALRNMAVRLPPKSKQALLDAGAENVLRDCAARHQASLDEAYAALRDLGCSAVVYKVDEQGNMQGTQMFGKVTSNFRAEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRS5</accession>
    <name>A0AAD2CRS5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS16855</name>
        <name evidence="7" type="ORF">CYCCA115_LOCUS3922</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000336">
        <property type="protein sequence ID" value="CAJ1934581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001952">
        <property type="protein sequence ID" value="CAJ1957733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1934581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1957733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="201" mass="23211" checksum="89B3AF1C24B3CF03" modified="2024-05-29" version="1">MLETVEKEGKTSIISWLPGDPQDTFKVHDKDKFMQQVLPRFFNQTKFKSFLRQLNLWGFERILESGPRRGGYRHSLFIKNQPFLCTKMKRTKIKGAKQGDTGDSQQQQTEGEQHHREAISHRSDDAGGQRLTRNKTNFLNDEETSFDTIEYEKIPDHVPVAADLSRMYDEMSVLLLPPAEAEEHSPILPQPTTNLKRPAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSD4</accession>
    <name>A0AAD2CSD4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001046">
        <property type="protein sequence ID" value="CAJ1941626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSD4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="122" mass="13956" checksum="E27DB0B997FF5325" modified="2024-05-29" version="1">MGWTESPPWFCAFTENVANLTNVDLQHNKRVPLHPLGRAAAVTDFEVRDTQVVRPIPKSHQPLKKMEVFVDDFVGMGQDHPSNPLTNQQAVLSHNIDKVFQPNRPMDNQWRKEPQSQSKMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUL5</accession>
    <name>A0AAD2CUL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="162" mass="17783" checksum="FDAE8FF4481A2707" modified="2024-05-29" version="1">MALETYFATLKLERGVSSFTLVEDGATRRTPTSPPRQNDSRQALRDALARTSATKFSIDECDEPLYCPTRQLSSGFSSESVSADSLEVLINISAGSLEALLNIDDSYRTASPSKDHLALEKTADSRWSSEEFKNQTDYPMHSLVATNIRAQPWRGGAFPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV20</accession>
    <name>A0AAD2CV20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase 2</fullName>
            <shortName evidence="8">MAP 2</shortName>
            <shortName evidence="8">MetAP 2</shortName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS10109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="134"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1945967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="458" mass="51016" checksum="F8A21FBB671D5613" modified="2024-05-29" version="1">MPEEEKKDSIVNGEEEEDEDEVNGEGNADAGGAKKKKKKKKKKKKGGGNAVPLAEKKEPSEKPPHRGLLPTAFTDAHVKYGQTNPPTIPVADVFRGFEFPKGEIQNYALESQSYRETSAECRARDRLNEDVYKKCREGAEIHRQVRNFAQSLAKPGIKLIDMCTQLENKNRELCREAGLERGIAFPTGCSLNHVAAHYTPNNGDDTVLGFDDVMKVDFGVQIDGRIIDSAWTCSFNPRYDPLLESVKEATNTGVATAGIDVRLCDIGEAIQEVMESYEVELDGTTYPVKCIRNLNGHSIDQYQIHAGKSVPIVKGGCEESLIMEEGEIYAIETFGSTGRGYVVEDMECSHYMKRFDCPHVPLRMQSSKRLLAHINKTFGTLAFCRRWLERDDGGSATVNGQEGKQEKYMGALKNLCDVGIITPYPPLCDTKGCYTAQYEHTIMMRPTCKEVVSRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CX71</accession>
    <name>A0AAD2CX71_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001269">
        <property type="protein sequence ID" value="CAJ1944884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CX71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="203" mass="22043" checksum="7B52091AA6862258" modified="2024-05-29" version="1">MTQNKILYSAELTNHMNRAAYFETNKVQIKVKSQLQFQLQFLGLSPVTGIITSEGSSVVGSVNTPLQLVGITGGQMMQVPAGMQLMQIPTQGGGTATVPYSMNANGEITFSGMQLSQQWFSGAQMYDGFDATQAPTPQVTKTGYFNMSNVFHDAIKEKDENGNDVYLISCPACTANVKLQADWHNASENEDLPDLVTEADQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZA4</accession>
    <name>A0AAD2CZA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS8488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000009">
        <property type="entry name" value="Oligopeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF83">
        <property type="entry name" value="LD37516P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Oligopeptidase A N-terminal" evidence="11">
        <location>
            <begin position="73"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="303"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1943533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="775" mass="86839" checksum="1229D89721F2D4FE" modified="2024-05-29" version="1">MKIKASAVFFIASLAPSPSTTRAFSPRASRRVAAATLSNRLFMSSTVTANPLLEQEGLPKFESIEPKHLTPAVEELLKKLEQDFATLETSFTKDDSKKELDLDYDQVLPAVERIQAPLGYTWGVAAHLNGVKNGDELREAYEQNQPKVVQAMTKFSQSKALYDALEAIEKKAADASDPPFVLQQKKRAIDNSLRGMRLGGVGLEGAEKERFNEIKLRLAALSTNFSNNVLDATKSFSLTVETEDAYKLEGVPDSAKAQWANAHLQFLKSQQKEGEEVAELPEMNPQKGPWRITLDMPSYLPALQHIPDRELRKEVYMANLQRASEKSDMDEKNNIPLIYEILELKQEMAKMLGFENYAQLSLASKMAPSVDSVTELTDLMAAKAVPAAKKDLEEITALAREKGGVELKDVKELMPWDTTFWSERLKESKFDMKDEELRPYFALPAVLDGMFGLVERLFNIEVKVADGDAEVWHPDVRFFKILDKDSGKHLASFFLDPYSRPENKRGGAWMADCIGKSEATNREIPVAYLTCNGSPPVGKTPSLMTFREVETLFHEFGHGLQHMMTSATVGDVAGINGVEWDAVELPSQFMENWCYDRPTVYGFAKHWETGEPLPEEMFQKLCDQKVFNAGMMACRQLYFGQMDMELHSETFDSKAAQKGEGRTIFDVQKEVAAKYIPHSMPLEEDRFLCAFGHIFAGGYSAGYYSYKWAEVMSADAFGAFEDVGLDNEEGIQRVGRKFRDTVLSLGGGVPPMEVFKEFRGREPTPDALLRHSGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D136</accession>
    <name>A0AAD2D136_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS10237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001580">
        <property type="protein sequence ID" value="CAJ1946096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D136"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14811">
        <property type="entry name" value="bZIP_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="146"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="614"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1946096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="698" mass="77653" checksum="CE8C4E4F2185666B" modified="2024-05-29" version="1">MAPYNHEKSGKQDSSSSPQPSSSVDSRSSMTQQDTFSAASVSPIPMHNPSPAELRYNPHPLHTSARTQNSAEASAAPVNSQQQCPDWTMSEAMPNSSNGLLQMGNSVSRPAIQNKENTKKERQIAPTKKRQSAKVQQDRPKGAAVTGRRQKRLERNRESARLSRRRRKQYLEVLEERVTQLSIEMDQGRREHAGAAMETVIKKRNAIFKAEAPIEELIAKLDGGLNRTSSELTVLSTFYIQQLKSLALSPHSKFILWLTLQGDSYFRGGRAASERLSAARIGERMLLGGNDKVTPINSMWPLVCNEIGLSYDQEERVRNFQRTLLQTPTTWLDRHTSRAAGLAVEAFDSSLKAATQSIRKREQVVAKQLTPKQRLNFARWAELNSDRMKTLLKTKRDRLANEKNGKEFEVSITQHTSANLYILNHRLRKVIGTLPQNLISFNSATLKRLSRRPSFESLGQQKDDDGNLTREGSFASSGSLKSLKRSSSSLSIDDPDRPQCHQIHPEDGQREAEPLVKQELGFVQRIIPSSVLSNPASNAVPIALPPTSFHGYSKPYMTSNAATAENLFSDSRYQHDRTMQYPSTIPSLPISAGIHTPQYGTASTQQQPLFQHVQQTQPAAANATASQQNQQADNAQQEMQSRPAKVHKRKTSFLPAHLGAVPEEEFNPGDGGAEDFFMSLIDDEDWAIGEGVDMDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FAP3</accession>
    <name>A0AAD2FAP3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11261</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16586</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS23565</name>
        <name evidence="5" type="ORF">CYCCA115_LOCUS23627</name>
        <name evidence="1" type="ORF">CYCCA115_LOCUS240</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1898069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FAP3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1898069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1969158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1969282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1275" mass="145644" checksum="09AB1C3A43D7A068" modified="2024-05-29" version="1">MVPPRRRFHKTPPARIKNRWPGDWDWQYLPIRELPLKTVPCLPWGKEKKFNTPTKTLHENIPGNGQVQPTFMLIAHLVQASNYLDETDYNVLTLVTPALAKNSLLLEFPFSRPWKTTRKRQWGFGKVHKDRYSTHAKVNPRSMIHYAWGFLSTVDRHNVIIALPQWRQYASLRRFASVTSLACLKEPRVLPTTGIPTRLDPTRAKLNSAGLLRFDFLHGDFIRWLGGEYVNSDRDFNAEWDVIDSTLHNKEVPAEYPPLKLEMAYRIQTEGVPIKAQYTTPMSATVLREEYDNHPAVAANSSKVEEKFAKEEWKAYHIHYLRFVFQFIPGLVINPIQWVFDKGKGRICIDCSNGPDDLGSINTYIPKPKQDKSGEQCPPIHYQFAFKRFLRQVLRMRITKPTSPILVHADDIEAAFRRVLYHPDVAVAFAYVYSDYLIVPVGQVFGSRNAPSFYCVLADLREVLATCRVDVPLDKLHALVRKCTIAVDTSTPLCTVPADSHHPPLSVTELVRMYNASYVDDNAVAAFAEHIKQAINHSVMSAFEVFGHGDKRRGDCLQDKKWEPEVTETFLFLGFRINTHNMTVSWPLYKREDLHSQLLDILKRRPRCVSPREMAKIVGIVRSASEIAPWGNFLSFNLQNALTQAAKNAFSDKRSWWTCSRIYLSRVAVATIHQLLETLLAPEDSPLWSRPIALYLDRDYTHRAYSDASYGGLGGWSADFSFLWRLTRDTLVEAGFEMREIKISSNDPALPDGFLHINPLEYLGALINLWICIKCVILLGPIDGGYILALLIDNTTAVSWMSTASRTKDPLLQGLARIGSALLVEASQLLMKVCPKHHPGNQNGAADALSRPQLQGKDHENSLASVIAEWSQLQTCRICLLPFELLSKIALTLKEPPTGDQQELSEHDLQKLDDAGCILVLGTYLRDVKRGDNSKEKEDLKADTLRNYLSTAHKYLQYRLGRPIQVMDPAYGGKQNRYHPFLFQQIHDRRCWQQKNERYEPFTMEMFVALQQWLANSPDPTATFLGKVHCVYDWTRLGIFTGFRASEYSQGDLDRGKLFNTIPHKNDVPKAFRGMPLAMMAIDFRFFDKDYVLIPHHHLVTRYNRGDVVWLELCWRYDKSAFNFVKKRFKITGHQIYCPVDAAVCIIRRKTMLGVPGTCPIGVWSSGTMSSYHFLKSREVSEVMRRSVDLAYPNPNHYMRINRHLIVPHSNRVTAAVCLQKGGANNDEIAFRLRWLPSSVPTYLRDCFQSIGDTLERTIQGAMKLTFSSSSSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBY1</accession>
    <name>A0AAD2FBY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000080">
        <property type="protein sequence ID" value="CAJ1929471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042232810" description="Pseudouridine synthase RsuA/RluA-like domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="215"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1929471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="535" mass="59783" checksum="265836606D6949C9" modified="2024-05-29" version="1">MTSSLDPSSSLWLWVWAYVLITAPTTFSLSLSPAADDSKSASSSNNNKSYYWNGLHFQLQHFWTCPSNNGQSTERTGSKLLADLLLQSEDVNIGFVSKSQAKRACQNGAVWILNSINKGHFLELLQRDLKTKSMLEMKSLHLDHSALIEGPFLQAHPSTILQPSDEVWIMVDRQWKSGWNGYPVFVTKNWLPPPASRGLLDSLAGCVLYEDDEIAMINKPKNLTTISNPMAASCCSMSSTSDDRDDLQSLLGFLLQCPIDGTTKFHKGDDAYQPRPVHRLDKPTSGLVLVAKSARAMKILSKAFAERQVTKTYSAIVLHGGDESGLYQWELDQSENRKDDPSWYTIDYPINGKSAISSWRLIRSISLQIGSRVLQQFCKKNYDKGELSWDHSEPSDSDASRDDDCNQKLSLLQVRPHTGRTHQIRRHLAYNLGSPIVGDTKYYAAGGQKRKGPFWKDWHTNQPRMYLCCHELEFPYDLLIGTQSTATMITAINSKSKTAANVTVVVAAPNVQGAPTLRLRVSIPLPSSFHDLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCS0</accession>
    <name>A0AAD2FCS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS1086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="211"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1924475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="285" mass="31718" checksum="1485858AB5FD820E" modified="2024-05-29" version="1">MSASNGTPVVGIPAPPPLPSGLATGKPVPPPPPSSSGDETMSTATASLTAGSTNMEPLEIMEEDEHVDDTESLLPGGPSSSQSNNNNNNNNTKHAKMQAVSKEYFNGLIKPQTVGNMTILFPENYFNDDQSAPWGVLGPQPMGPFCVWLLICVATHLIVQRALTIGVLTTLTCYGFYCFCTYRLVDVAFRDPGMCFYQAIPETLDEEQARQWRWCDFCNIFQPPDGAHCTQCDVCIEGYDHYCVWMGTCIGKKNYKQFVKFNVSWLWYLLYYLVWVLLIGHFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FD56</accession>
    <name>A0AAD2FD56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FD56"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="160"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="628" mass="69345" checksum="D4B00D44E061AAA4" modified="2024-05-29" version="1">MKAIRSVNEVQTMSDLLLALTDMSLNNDNVEEEEDDNPAAGDDDLSFDDPVLRAMQLRDLAVTTAAAAVLDDTAANTNPANTTISTGVQGLKLNLSDSSSLLHASADSTPFASKDWVLDNQNTVPDIEYQTQTLDSEMRRLLVLRSYLLLDSDEEDDGDGSSLGFGAITRLASRMLDQPIALVSLSDIDRQWFLSQYGLGGGTNQICRKNAFCAHVLLCQQEDVMVVPDATLDPRFQNNPLVTGPLQVRFYAGAPLIAPEGYKLGTLCVLGNQARPQGLTLEEKQNLRDLADMVMEAMSRRRKEKIRAHFHNPKQTIALMAHELLTPLMGVQRNLATLSEDSSLTDQMSPEEQELLQNALYCSDAVSKICSTAIDDLRLQQRVLANKKRASFLRSSSALRGPDAFKTSHLIQAWYIILEAFPKYVPVSITLDESVPKEICADELKIFRSALNFLSNACQRTFKGSIQLVVKMIAGQNTTTTTTTTDNDTSDMEEDGAETKTNEDHSATQKGGSKNYLFVECLDTAPNIPIENYPLLFHPSDSYEEQLECVRPTANGGCEPICRMQTQGLGLYSVAVQIGSIGGEYGYKPRFPPRDENVDGNGETMMTQQEGSIFWFKVPLYDDDQEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEZ3</accession>
    <name>A0AAD2FEZ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000313">
        <property type="protein sequence ID" value="CAJ1933914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEZ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="93" mass="10918" checksum="E03D04CA252345C7" modified="2024-05-29" version="1">MISRSKQFRVTLEQIRIYKKQPKFRSNPCSDKLMKLVNALEASQGKMNGPVYKYVKDVEECFNKAKVEERKSGQAGTLYYLSQYLDVNKFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGG8</accession>
    <name>A0AAD2FGG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS1675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000080">
        <property type="protein sequence ID" value="CAJ1929406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02135">
        <property type="entry name" value="YdjA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052530">
        <property type="entry name" value="NAD(P)H_nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026021">
        <property type="entry name" value="YdjA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43821">
        <property type="entry name" value="NAD(P)H NITROREDUCTASE YDJA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43821:SF1">
        <property type="entry name" value="NAD(P)H NITROREDUCTASE YDJA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041931452" description="Nitroreductase domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="9">
        <location>
            <begin position="41"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1929406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="227" mass="25382" checksum="96D9AB3A30223887" modified="2024-05-29" version="1">MQLRKVLLFCYFLASSAEIANGFFLQARRARKAAKNVQDIITSRRTINEFEESLPTEWEDVITKGIEAACQAPNHKRTEPWRFHLLGQESVRNVCELNAKLVAEKKGQAAGDAKLKRWLAMPGWMVVTCLKQEGDGPVTMEDPMGLAREDYAACCCAVQNFCLSLHAHGMGTKWTTGPVNFDDEFSKAVGLSSDEFVVGTIWFGRPVSQPMAPTKKKSMDDILIRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGI2</accession>
    <name>A0AAD2FGI2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000091">
        <property type="protein sequence ID" value="CAJ1929611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="41214" checksum="78293867D48607F1" modified="2024-05-29" version="1">MHFEKKIKGRLVYRGNGTREWLSREDTASPTALQEAITTTCVINAHKGRDIMSMDIPNAFIQTYMPEAKEGEDRIYMKITGMMVQILIDMAPEYREYVVLENGKFHVDDLMSSHMDPKVNDEFAKWLNMRYGSIKACTIVRGKIHRCLGMTLNFSVKGKLKIRMDDYVKNMLEDFPVKFNKDSKQETPASNDLLEAGKGKLLSAEYRQIFHTTVARGLYVSKRARLDIHPTITILASRVQEPTESDWKKCIHMMLYLFCTLLYHLILSAESPQVMKWMIDASFAVQPDFKSHTGCTSSKDAKETKTKQQDPSQLFSNAQFVFVEFAHTPMRGLVFWCHCLETLKSIVKDWQRNIQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGM1</accession>
    <name>A0AAD2FGM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000558">
        <property type="protein sequence ID" value="CAJ1936814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="310" mass="34058" checksum="D6F7D36BF8BAF2C7" modified="2024-05-29" version="1">MDEEMLEAAVQFVDKLVELGVLRSTDEGLTVLANAPLFVVGKDGQPGQWRVIADMLRGGQNDCVGQDRVFMPRIAHIVDQMYTEGYSAVVDLSKFFYNFPTHPEDRPYLGLLHPKTEELLSYYGLAMGAGNSPAIACQIGLAFLGYGFILTSSDGGAVHIWVWVDDFLIHGPTHKKTAQGLQFFLDKAVDCGFLFHPKKLVPPQQVVKYCGFLFDTTTVPCLRIPEAKKERALAICDYLLQSPKHKKSSSLGLAVAVGVLESLTEATPRRLGHTHLKEFHTIVHPPGLGNGAAPYYTTTSLNSAVLDKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FII9</accession>
    <name>A0AAD2FII9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS8245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FII9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="201"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="391"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1943036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="62031" checksum="8853A8EB6A9F6B97" modified="2024-05-29" version="1">MTSRSRDNECYDYVIVGAGPSAMGLLYGLLVDHLPPFSICIVDQGDDSHDDTTGDPKDWYAASHIRSSKSVYQIFSTITNRVVDLPIGKGLGGTSNINATLCMPPLASDLESWPSPWKENLLIHVQEIQSVLKNNEVLQGAHGSCSNPSSFPFKEKSSLDIMTGVPTLATKSDGGTSSKFEYVRRNYFDGLVEPLLKNNPHLKDSVVFLLGSQVQRIIMDESNAAAKGLVYSSRNGELCTIHARKEVIVCAGAIESPILLQLSGVTLGGQVGLHLKDQVLIPRVFFATSMEYTKCKTVNGIRALGHWREGRDVLQVAILDTSTIQSIVPTTVAMAVRRNCNGFLFSQTWKRVFEFIYLVFKGLVSWTLWCMPVQRLVESYTVTTLVFLMHPVSEGSVRIRPRDNRESQDELMRRDVDITVNVNYLQDQKDIETLRRCWNSTCQDGRATEIFPRWMFQPVAQIFFSWNWFQGFCRLFSQPYYHFCCSCRMKTTGRDNWVVDSSLTVCNHSRLRVCDASVFPHTVSNPPALTCAALGYGLAKILVATVEKDKVCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK77</accession>
    <name>A0AAD2FK77_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000613">
        <property type="protein sequence ID" value="CAJ1937169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041962457" evidence="3">
        <location>
            <begin position="30"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1937169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="533" mass="59619" checksum="C197B43CD7572D68" modified="2024-05-29" version="1">MAIAGPHEIPITMKFAVLVMAALLGVTDATGISNRDLKVLQARAKSGKINKQTLMRGATPYSAAAKRKLDQEEEWEINGYYSVEFDTCISLETGNDNLFDDEIIAYAANGQVKSERSYITFTVCESSNCYYLSDDEKLTFITDVGTYFTALAEYLPNQVKNYCEGCEENYDYCSGNLQAEADEEDAAENEGEEEGDEGEEEGEEGEGEEGEGEEGEGGERKLKRNRRKLANNRYVEYINCDQCDAYECFADMDNNGERKLDQEQDEYDIDNAIEWLNGLAECQELENVVYENTALYAGLICNSKGDGVEIGVFMDDECSLYTTLKSFSDVMTYSDKQYYSMSQEIVQYTFTNQFDCQNIEIEYTNPYEENQDEDEEEEEDNGEAPEAAEYCTDLFDNTVNMADCDIDQNEEQQEDEDQDGDDNMANYEWYSYEISNEDAEDAQAVCKVLNGFDADSGKSKSWKGKTVYDSGNSGSLYTYKKSKSSRNGGGGGTFAFILVALLAVGGVAFFMVNKKKSDSKRAPLINASNGQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM17</accession>
    <name>A0AAD2FM17_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="839" mass="95179" checksum="5C70AACC53991A95" modified="2024-05-29" version="1">MSSDEGHDEESATYNDKPQDGQEPLHILVADLQEKMLTVEAKLERYQDQGVRKRPSTSRPSLKEAPVATSMISMQMDLEPMDDDEDDEDDVAAFPHSTVSFLLLAKWPLCGHSPPEDAIECSQQGHVVRAKHRSRDYMCLPFWFSWGIVALQAGIYALALSNAIDITNPKNPLNIPVNVDPFTRTAELIAVAITVYTQNNIFQGLDLFVQNFKYIREVPGVTVYKYYLAALTQVNIGIFGIFVTFLIIMQSQEVVDLLLNFTAMEFVASLDDAAFDLAWRGFFGRAMKDTASVVAEVKYAPKDKHKWLRKWPLFVVLLVLMGCYALIRIMQDNRMFGDNEVYIQLHDDAIPWLSTLSGMYIGCYLPMADYSDIRERTDSSIGRIIYTKLPTDRCEGNWQNEHAAFFYCGESWVFAVGDDMMYPCDQWTLRSFKSSSANIDAYDILTHSTDPWFAKDEKNISKDGVLETVEFLASFVPSEHVDLLCNDLGSEGFAFNFPVYERLDIFIGDRPVYYADAELLENEINGEYIIYSGRRWLAIKEKYLNLDCISDCSRTFIDAPCRTECLRSFDLYASNYTVHLISDPLDLRTTADTWVPTDDLRWYAAEGHGRASKPHIVKKTLLQHIQDIPVVLEAGSAKNATNQQLAEMEELFVPSANLHCACDDKHEEDCHGILYCPDGGTKVWIDLKTDSHAHEIHFLVTELGYFHDTLVQASQMHPYFEWGDLKKEANGYEVLNDTGHFDWHHVQSGSFAHLEEYMYVSCLPKDKCGVVYFEDTFGDGIANPGSFEVYANGKALHSEGETELVSKKNCAYHFGETCETEVICSDRPLDVADFFATGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN84</accession>
    <name>A0AAD2FN84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS10884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001717">
        <property type="protein sequence ID" value="CAJ1946886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677:SF59">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="122"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1946886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="344" mass="37973" checksum="48443E5545ACDDFC" modified="2024-05-29" version="1">MRPAKVANQTDPPFLPLEETLSKKKSSEFLNPSLGDDVEQKKKNGRTRWLPKLSARKVVAVTLVFLVSIVVFESFFVNPEDRLIQPDFSDRFLQWVQSHPRLGLWAISIVIAAGVATMVPVGTPLTIGCGYIYRGLYGWKLGMFVATAVSMTGSLLGAVSCFLIGRYLMRDTVQKWVRKYPLFDAIDVAASNEGFKIMSMLYLTPVLPLGLVSYMCGTTSMRLASFATAKIASLPLYLLYTFIGASAHSFMKHGAPEGNNVASALEGTKQIEENQGILLAGLALSTVMMTLITRHIRKELMQILETQKRDKNEKDVENGEKLAETSAEESGVETGLTARRRAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP50</accession>
    <name>A0AAD2FP50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="52"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="281" mass="31068" checksum="A9AED1902E5203B6" modified="2024-05-29" version="1">MLNMLSPNTKSDKTDGAPGKRAACSGKKRRRLRFEETINPNAESITNITAIDILFGRGRGYQDRPGNKRMRAIVATHKERYQALELSSKRTFVEAVYDEITRDGARFLHKQGDEEGFVMVEVPVALHKVRNLLRCKKSFGKMTDPSKKTEKAESSDSFQVRAIKTPVALSEGSSTASAIQEPSIRQAVAAMSFPALPLHVSSTPLLPMQHLQQASLASLGNPIGLQSWNAGMSLGSLPLQMSAIAACNAAEELQMLQQYHHHRRSAEMAHRLRSKQPPRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTU9</accession>
    <name>A0AAD2FTU9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001820">
        <property type="protein sequence ID" value="CAJ1953141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="448" mass="52577" checksum="678D28D90CB3B5BB" modified="2024-05-29" version="1">MVFKAIPKVLTIALLKHVTKVINFYPAKEGISKYYSPHMIVRQKPVDFSKECVAEIGSFVQGYGHTTNNSQQSRTIDGIYLGVIDSIQAGHMLLDLNTKKTVTRPYVTVLPITNQVIKIVEQMAHNKGVRDLRTYHWKNGEIILDGDLLAGVDPDELWDDTYIPRKNEYKQSNENLCNEKIDQDEIAALLEEAEEFIENYENEHTKNVEEQTEDRSVASIYEQLRQRNDDDNCDQDPNPNEKYQNDEDLNEKIQEIEEDIQKDKEDVESLNDEEQIKETCKTYQENDDLIDQIQDEIKECENQVNDVREFVANLDDNKNENNESDDNSDESSDNDNDENDEVNKEDIFSPRKTRSGIKMRPPERNNWDQPRYNQQYLNQKKLKSNLLKNRSAMRKKEKVKRLKGYLNDIISMKENSRKRIPKKSRNTIYYSNRLEVTRKPNMEKIRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU90</accession>
    <name>A0AAD2FU90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS14312</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041952889" description="ER membrane protein complex subunit 1" evidence="13">
        <location>
            <begin position="22"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="975"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="15">
        <location>
            <begin position="72"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="14">
        <location>
            <begin position="789"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1953709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1008" mass="107757" checksum="8A4BABF4C2AEDEFB" modified="2024-05-29" version="1">MRFSFPLSAVAFLLMQPIASAIHQEDAGVLDFLVSTSGHSVTQFVDASLEGSIVTTDVPSGSPTSCFIANRAVEDGSLMWRRNVCSAPGDEQNHDIAATADNIYTIDNDGSVRAWTKETGHLIWDARVQPSMSPKVWPVSKQGMQFVVAASNEEVSIFHAESGKLFDDRINVAKVAGSAKAGESLAWLVALPDTMDSGKIQSIFSFVKEDGTSSKMIMVELEVGNDTIVSQKSLGHAKGAIIASSVKLQKVHDSWQAVAVTTDGNLVYFGVEGSNFAKTLSASELMPEWEVVSAVRSTEVPSIISVQSGDQSALFNVDGSGGLTPFEIEGASFTAMAQCYEAQLDIGLTADSLRVYRDGKPMTLEGDLFVPDGDVIEQLSIVSCSADKASALLSTASGTTTMLGFELKGSSVDIKIGWSTEEGLGSISSAVMLDASHLGSDDLVEEEAAIMEKLSLPSRLSGQVSSILSFGGNGNNRRDHNFGFVKVAALLSQKADRIWGLSTSGEDRGMVRWSLDLPKSAEWHTMVHGTTNSNSAIHGINGGTHSREILVLSALEGSVEWMCIDGTTGAVNAQDTVSIPSPVVQVIPMYGGAGGCRQASLLLHDDKTLTPVPSDGATMDLVGEQLQKSPNGLFTHFVDKKASRVVSYQVIEGSNNALGSIQVGQATFAGEKIVKVGYPTRDEIVQSMSSVLGDDSLLLKYINPHIAVVVTVSEAKEQTPTEIATTIQKEETKKKGRKPAGAGSAAEQTAPSIVPNMFINVVDTVSGRVVHRAGHSNVDPSRKVTTLISENWIVYSFVNSVTRRTELGVLTLHEGIIDKKGMTMFTSPQQTTSFSSFDARESKPVVLAKLYIYPSAITALGATATRGGISNRKILIASTDGRVTAIDRSMIETRRPMGEAKETEKKEGLVPYRELVPEVSLFALSYNQTVESPSSIISTHTSLESQSLVMAFGGPDLFFTRTSPSRGFDLLPDTFSRVLVFIVTTGLIVVLFVVKNIGSKKALKQGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW51</accession>
    <name>A0AAD2FW51_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW51"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="247"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="33473" checksum="FE87E3B6DFA6BAC8" modified="2024-05-29" version="1">MDHVSKPQREDTATAKDVLNVYATNTRYKSTESHPWQRHSLPIDHDETLMEFRQRLVELFKPFYNNTDIPSHGGEATVTMIAVDSDGILLFNDALQEDESLYQNSFKEGQKESSERHTRNSKFRYRDFQALHELGIQPQSHIYAFPTFTTNHRCAVSLHLKFPPPNQNDPVLIKLPSLFSPCIMVKVILVDLQEQQRERQNVTTGTLLQGESHEDMDIDNNEKDHNKPGVMMASTNGPTIRRHRSIDRMRLLFAGKQLENFRRLVDYGIGWDATIFVLYRQEDASSSAGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWX2</accession>
    <name>A0AAD2FWX2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS15654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWX2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="275"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1955241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="350" mass="37370" checksum="5723C61FB2A14744" modified="2024-05-29" version="1">MAPPSNTAKPDAKPAASTVKRSADGSATAPVAKKPNTANPQQSQLQQQIQQQLQAQLQAQLQAAAARGQQANITPEQIQAQAQAMVQAAAQAQAVVAAAKSRGDGLVPMNSAQVAALSQIQAQAIVNARKSQGTPQQIQTQIQLQAQALVHAHTQAQIAAGIFKGDEVSSSPAPAPAAKPPPSAPMSDSRARAIGGSAMDSSKSIPNPVMVSSSTTMAMDGSTSIVPQAPAPSSSSPQFLAQLNSSLNSFWKEQLKVVQTYKQQTEQDFKTHNDLPLARIKRIMKSDEDVRMISAEAPVLFAKACELFILDLSIRSWNYSQLHKRRTLQKEDIREAIQKTDIFDFLVDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXU7</accession>
    <name>A0AAD2FXU7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1955989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXU7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="283"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1105" mass="122161" checksum="4D79CF57793B88A6" modified="2024-05-29" version="1">MAELFSRWRTEASNSVEDIYGTVMLGDDAGEADRLVVILQPPPLLFGRRSFGNRMWNTLGLTFVNIQNRAYVQQIEEGSPADLQGVRRRDCVQYAAVLANEWQNPLTEDYEEISKQALEREATGQRISYNDLKKILERGMDTSQSSTFISPPSVPMTISVDRTGSSSKPQKHDLATPRPLVLVLRRTRQREPSPSTSWSLSIWPRFRLDDECDVATKIIHALALDNSVEARSIRDNMQTCTGVAFLRSNKLTLGVSFHGGSGIVLSKLDDGSWSPPSAIGNWGMGVGLQLGVEVSHTLIVLRTKEALEHFLRGASFQVGVGIGAAIANYGREAVGSASVSGALCGSTHLLDFSKEDEYEVDNVAAAGETAPIEFNNNKLINGVTPMTAYAMSEGLYLGVSLDGNKLFTRHEVNERVYQFYQSGQNKGNRPSSATITPQEILQGKVPVPPEAQTLTAALIATEYRHDVQALPKLPSAPNKQWESKAPPMTLSEEQTKIVERLQQFLFGGIAVTQLPSVADSRRRDWGRTLWLCSPGPGMSLELGFISKHSERKHTSGSTSYSKANHHNGDTYSTTSEDLTLDSALMDNQSIVNGAHLNGTGNGPTTRVELSRKHSVALTDVITLDQEFFGITEDYQNQIVSLTTNANKKLVFLTHSADQATLLINALYLLLEYETAQLGARGGKGRKLPTTPSSTARSPRRAKRGAKSINQIIENGYSSSEDEYDHDEEEDDEQFAKLNSLPVGWTSWSRIPGRSYLKKQATLSSDECPKYVHGQLLVRDICKSVHLPLDLPMCRVLLLDSSSPVITQWEQEGGDANFEKTPWTFPPATPREMDQYQSEHQLIASGSMINAHRTISYERRRNGQNVRLTETNIVESDDSEKLSFTVSERMPRRGFSVKVKVIVRASNDECCTATVVSEMRPVGKNMSNPAAVHKAFLLVLDELEGRYGTAAGGLFGRFLSVVATLPKDSIKTQAKKEAPKSQAEEKKETDSGAVALEDMLKSTVSNDALDRIDKSSSVNEKRPTELKKGSKRASKSDKPAVVDEPMETTANAPVMIEVKPLPKIRLSLMPSPREEDEDRETQKKKEKKKEKKKKSKSWSKKKKETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYY2</accession>
    <name>A0AAD2FYY2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYY2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="558"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="679" mass="74790" checksum="44F44DCD096F5167" modified="2024-05-29" version="1">MSRKAQENRSEWKTPSIYAFSGDYGPFKIRRNEPIDNALVYFMKDGITAVSSAKAGSTAARTQRQHPMLEMAAVAQQLLLKPGDCSTQEYLFSAILVIHVSGMMVDTDEFAKAMAREVTERELCKSFGKPLLRLLKRLMLRNVTLAASHDLCPLAYKLFQALLAQSSSATAELAPQLWLLYPYLPAKFINAQMVEGAQTNTGRTMPKNRKSHKSELHLIFQSEVARDKRLDMLRHVCSVGTCRVMDSVPPLQLLLAAFDKNHIANNDKNALAPYNVDYCNGIGKSLFLSTVKVEMNRFTKQYERDCEEVTADLTVAVEMKPEPSDSVLPATAEDWSRCERQVGALVLRGNRCVLVRSMTAKWHGMRLPSVAPRPGEGDKEAVVRAVVELLEVDADKIRSLPMIPPVSIYGPNGQPTILSLYPLYAVQPPPDGPLEEADMEDDESPYDWYTFERAATRIDAASIAGLQTMASALVAAANVGILPCQWGGVFGQEMGMMCSTSSVAGQQLTVAPEKWTPSRQGDVLQEVRRANSALMERRLSNQHKNGTAVQQTSDFRLPVTILSGFLGSGKTTLLTHILSNYEGLKVAILVNDMGEINIDASLVKKQTSVSIHQAEEHMVELSNGCICCTLREDLLAEVSKIAQAGTYDYLLIESTGVSEPMPVAETFTFEDTTGLRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ53</accession>
    <name>A0AAD2FZ53_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ53"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF124">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="261"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="398"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1956379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="450" mass="50020" checksum="B699D4780B91C0AF" modified="2024-05-29" version="1">MIGGAPLHVACAKRNLEIAKLLLDKGADVNCIWKKKRRLKTDCLVDFKTLEEFEVAHDSKYEEGYSPLHFCRSLEMVQLLLDHGADLNKKTSCGYTPLHHACRKGHLKAFQFFLDLGANIDSVDKRNHIPLTMACTSGHFEIAKLLVDRGARYKEVEDSEWTPLHDACQFGELEMVCLLIDQHANLEARDKNGETPLQLACCRGSLEISRLLVDRGAIVEPSNEYNYTALHYACKMKGENGLELVRLLLDGGANMEAISVRGNTPLYIACAAVVHLKGGDNLELAQLLLEQGADIEAQTIEGDTPLHIACIMGRLEMVRFLLDRGADAEATNSLKSTALHCACTVEIVRLLLDRGVDMEAKDQNGRTCLFRECDRDDSSIGQLLLDRGASVSARDPRDESTLLHEACRNDQSELARLLVDRGASLDARDCEGCTPLHRVCERNPFMFFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ63</accession>
    <name>A0AAD2FZ63_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="327" mass="35956" checksum="695A9BE3A4B38487" modified="2024-05-29" version="1">MTEQGESSKYVIVSTRADLLITQEIACLISSEKPSSQIFIACPSPCIDEAQLWVNEIKNGSGDDDSPNARSIQVVPFDPHGDRTACRRASDELIKALGDGVVNALVMNWQGCLPGRFGVVLEESGMLEMAQIKILSQMYLIEALIEKKMLFDSSRVIVSGSEAARGIPPMFSAPILGESLDSYVSMLNGTGLDLNNGHSIYSHLQGILSLYIASLARKHSIIHFWLLSPGFTQDSLNKHIQIEENPQQFKFEDLVQYGIAQDYKVAATHFFRAMIGSPEWNYPSGILVAAAKGTRGDLCDQATLDDGKYLSDYKKQDLAFEAIHSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZM1</accession>
    <name>A0AAD2FZM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042015261" description="Peptidase M12B domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="75932" checksum="C072CC07D6716B02" modified="2024-05-29" version="1">MKLNLFLFFSGLGLVSSQNAHQGRKTIKAINCNDNSRAPRCQVELEIDVESNDDIDFTLPNGKKISYKKKPSKVEGWAGESPAGGAANIISSDNGFFGSLVDMEDGAWTVCQLRRDFAGSQVIDCKPGSDYPDSEDSEDAEVEVSPASRMLTDNNKVRQVLQEGRSLQITPVIDIMVLWTRDAECNASGMAGGCTTTSTTEQNMRGLINLAFSETNTAFTNSGINAEVRLVHAYRTSYTEDSVAPNAFVPALNALEAGIDDGMTNSIALRDEKCADAVAMIIEDDTRICGLARRRTSSPYILPINKMVSITRWDCATGVYTFAHELGHNFGCIHDRGAESSCDTSAFSNTNFAYQEPTAEFRTIVSTNCDSDRCGSNPLSACARIQYFSNSGFASFGGKATGNANNNNAAQINNAAPIVADYNTCAPSAAPSDAPSGAPSESFKPSAVPSESIAPSGSPSESNSPSGAPSQSFKPSAVPSESMSPSSVPSKSISPSGAPSESIAPSGSPSESMSPSSVPSQSFKPSSSTTESMSPSSVPSKSSSPSAAPSESMAPSGSPSESNSPSSNPSESISPSAFPSESESPSVVPTGSEQPSLSKSPSTAPSGSSSPSGAPTMNLVASAAPSKTPPLSAAGGGGGGGGGGGNKPRGPWGSDPNQIKSPAPSIGSPSESPSTAPSSTTGRGGEEGGEVLAPPPTMNQARPAKAPKMNKKAKSPGSNKRAKKLQESRKGAKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G090</accession>
    <name>A0AAD2G090_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G090"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="312" mass="34729" checksum="1ED2DE58ADDCD321" modified="2024-05-29" version="1">MGSLMADGDNGDDNNSNCEPEATDAGEDKATDESEYKATGAVSEATGTDGDPDEATAPPPDKATAPPAVRKGAKQNFDSIWCSPSMPNTISFIVACPVEGCHDPVVVGKGRKLCSLKGNDLYNFASLRHKRLPSGLDKNGGAEQLLPRAPEILLQKLKPRQVGVREKKARLSRKERYAVPSDDEEPMGSDTEMVLSRTLLAQPSKAGWLDLVLLPRFPTYCQKMRKHYKTHHMGHKLPSGCESESLTRMRSNVEMWNTSHSDRQIKISVFQQNYKNVCSEQLLDEMAYFVLDDLQKDNLWQRIIEDYDEKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0K6</accession>
    <name>A0AAD2G0K6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS17414</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0K6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="27"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="375"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="679"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1958912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="721" mass="81712" checksum="4A12308B2ED84637" modified="2024-05-29" version="1">MAAPSKMPGITLADDNEAKLRGFEQDYEVGEALRSGSFGKVFTTKHKVTDEEFAVKIVDRTKLNAKDDENTMREINIMKDLIHVPHIVKLVDIYIDPKTYFIVQIFAEGGDVFDRLGKRTAYTERDARELSTTLLQTLDAMHKLKICHRDLKPENLLLKGKWDDAGILLADFGFAKHIPNEGLKTRCGTPAFVAPEIIKGQVYNQQVDMWSCGCLIFMIIGGYPPFQDQNHRGLFRKIRAADYTFHKKYWSNVSMAAKKLISGLLTVNPKSRLTCQAALNTEWLEVDAMKLSSRDLTTSLSEIKSFNASRKLKSAITAVFVSVASNFRHDKVSDLMNAMDKRDESSGSTYFPVDDSKPEKFKMSHMHNKKFLDFYELGEKIHAGTFAVVYECKHKRSDTKYAVKVIQRDGKPETDEAVLHEVSIMAGLDHPNVVEVLDFFEDDEKYYIVMEFLGGGDVFDRILDRKSYTEFDARNLARFMLETVAYMHSQGIAHRDIKPQNLLLVSHDDHARIKVADFGFAKRVHTPKSLISRCGTPSYVAPEILNGKPYDQMCDMWSCGVVLYSLLCGYTPFADDNQEAMFARVKAGDFEFFAEEWSHVSNDAKNLIRGLLKVNPDERLSAELALESPWFTQTQHMLSERDLSQTIAEIKKRRPGLRVLAKAFMGLSSFPKNMKKSLETIQSRPGSRAVSRANSRANSRANSRANSRNNSYNEGSEIKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1L6</accession>
    <name>A0AAD2G1L6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002012">
        <property type="protein sequence ID" value="CAJ1959623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1L6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="973" mass="110878" checksum="83F9186F741A1846" modified="2024-05-29" version="1">MNRSGSSIVKKHLNSRIVENTTAILGDGATNAEDELGHDFKQRLKKTLSHEKTDKTRRDYRNRILRMTKYFQQKCFRYFEAGVHKNTSAEMNDPAMYFYDKYEYDLIYAGLNVDYVLKFLMDQERTAAGNLRTKADMQKFRDAIKWGAQIRGEALSQECWDKLDLYLFSYKRQVAAGKGNGDVQTKEADPITKELYMLICKWASEDGNTMVDFWTKTQWNCMSRCGNIDYLGFSNFRIVLDAHAVTHDTTKKDKDGDRCFAKHIYANHEYHYLCQWTAMGNYCALYKNELGQTQKLFMWNTKDGSAAKKYQEQLKALVNKTEERRNIVSSHCRKGHFNAYGLRKGAASYASSGTTCAPSLSSIAHRGDWSMGSVFDIYWRFLPVGDHYLGQILSGKDPMKPSFKTLPPHWKMANPMGHPLIREVMNANFGPILKTHSEADYDPTGLLLRCLACMVWHAKSFQEYIAHNPSNELVKVPFYNMRGSEIDALQQLITVEPTPDVMTTVTGVPPHIETTCQMKAIHDNLIQLLAQTRISEDNQKQRDEQLKADLVAAVHHGIEQNAISNGNITAKGINDIIQKHQDATNKQLTEHLQAMLRSLPPQFQGGQPAQIPPPGNQVQQGGGLLLQKPDQGKYFYTERFWSVPEDFEFPPKPNLPQALRCWLKGIRYGNNYVKPFRQLRPKDLPTTALQSQMRVEWQKFFKYLENNGLEMPSNTSEEVTEAQLERTTDEMWDLLEKKVSYAFTRKNAKSHCLSTFARKVSPSEIVKNGNPSDKTYLESRQKAKPAARQYKNRVRPLAKNPKYLRRGKQKTTANATNPARLQQATIHAGAGILLEPIDHSPRVLNSTRYSIEANAEQDRMMEEYGVGRGPTGPPAVAIGHHDQTSPTYLQELIDRFGIRHPYPPISVPGPLGPCACAGCSKELELGRHRCARCNIVIHNNCAMDRNWYMQKNGEEMCFCSDQCKKNLPGGRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1Z3</accession>
    <name>A0AAD2G1Z3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1650" mass="181424" checksum="7438B746C189847E" modified="2024-05-29" version="1">MPNTFKPIVNPYRKNKPINRPATGSSVPSTAAAPVKKQWNPQNKANVKVQGRPSSATKPVTPINRSNIRKTPSQQTPSGITPVVNANPIASTSPPVVRGLPKVTPTKRTTPIKPSMLKKKNSLKQQLKQELALLKRRKTLSSLQKEADERRRQKEKERAVKMKELQAMQEERQKMKDEKQRQRMEILKQKEEERIKKQQERGAERLRKQQEREKRLEEKRLKEYEMHVENCTAYQKYLLQCHQYQQKALQHRQEQQKYQAQYVQYTRMQAQVLMQAQMGMFRQHPMPQQGMMAAAGMMVARPTMVGNFMAPQQPVAGNWNACYQANNMVPQFSVAFPVAPSPSSGMITANPTPTGNSNPPQPLVGTGTNPSIQAADKLPRDSSAAPTVANESTNGSSMAAPVAAVHPPQPSIVAGNPQFPSRMSAFVRPPLQKVTTPHLLPPQFMQQMHPAYTSGPSYPAAAMGISPPVAPAPLPHPPVPPTGVQRIWKPWRQARPQAQPRPKPIEIARLCEVTKGPSPFAHYQLLEIKLVRPEDEKSFGVSLKLFQQSTLVDPEWYDEQIRKHLGLAAPTKTTSLVPAIAAAKTDDGSNISGVQNPPTPVNLSTAADQKESSGNSEEASKNGSNTDDKVQVENAAKAKSPKPAEAKNPSLPPGSSTQEEKQPEPQITAGGQSSGESTMGHSSLPTNLSNGPPLAKDSTTPDSAIEKSSTNPEGSTNLTEKEQPHSASTTPPTPEATTSVVLEQVKPTAISDRPSVVGDVKPTSDGSVPKASGSVTTAPTPIAVLSSSPAATAKSTRRRRRRVNFSVMLVVDTTKQNGYRDKAGPEYGTTLLQTGDIVVSIGGTSIANKTFAQACAVFASKSENSNGFISANLVVARRPKPAPKPLAPKLTSKLSSKIPKGQKPSNDPKGMVLANSNQPFQAYEFAAIADSIIRAIHQPSRLLGQHVSTLPAFEPMISMFQKIGTLKSFGFEEDQFPARSIPALQTQWIEQSRRMESELRVKHQAQWTKKIEAEGGFQDVTFSSDAQRSSLRQMPRPVRGCRCGREDHEYLHDPKCLLYRDICRLVPPNVLSGLLRTDKKVSKKKDAGLNTVEKGFKDRLVKLKAIAELEEQEANFVAHMEEVQVKQCKKAVFAPTALSSMILSAVFELQREFPTNFVHYDEDDSDSDDEEEEVTVSGDKRTAHSSKRPKNKRQKQNAAVPKMINFRYMLRMLQYISKTWGHVYREPSHEEFAWRWELFHGHHSSQGQWESQAKNPRTPNSLPFEMIQAGEIDVQSAADLTLLRSTVAEFYGSVGKEFDDVMKRIAAQKEAEKKAAMALSKPLTKEMRTTQSTTVNPPQASNAADPKIKADGSDFDMADAVTEMNVYKNTTKPTTMEGSKLMIVDPSAATTSNGVTSTKDLANTTNASTSPVEAASEDVKMVDSKGIATAKENIGPSPNAAATATSTAPSTLVPKVVSKNESNLLSSTNSTDSTATNTIFGSPAQTKNVNMSDVSTAVKVEEKKKPLPRFDVNQESADYFLMAAHLLYPSTSGLYDELMALLKMDVLKLDPSGIPGLAMDWYTNVDIVILEDLDRCFGSDADPEGRFCINDELRDTLEEKWVKLEYGWAMTDDSSDLVFEYDVIDAWREAFQGEMEEQANMVEGVGRYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2R2</accession>
    <name>A0AAD2G2R2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Strictosidine synthase conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS18666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2R2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="4">
        <location>
            <begin position="213"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1960308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="433" mass="47580" checksum="F7B54FDC51358812" modified="2024-05-29" version="1">MNSSSKLILGVVILAVTIQWRLYSLNLWPVANILPPLQPFPSNDSRLTGKVEIIGKGDLLGPESLVLGNYAGKEVLFAGLTDGRIVRIEETTENNNRSDLSWVSLVRTGSIPLSDSTSCGKGWFADTSNTEAICGRPLGMQLVKRSTVDPSHSDDSSTTQEDEDVLVIADPYIGLLMITGIYEDTAMRHILATRAKTDPEDTHFHLLNGIVQAPDGSLYITETSQTFQRRRIFYAALDGKPAGRLMRYTKETGQVEVVSTGIFMANGIALSYDQKYLIVVAGVQVLKYSLQARAMEPEPFIYAMPGTGDNLHTAGRLPTGEVRDCYWFGLGSKYSRPFSLLNAVSGQPFIKSIIGALVPYKNFVAAIPKFSALAVFDAATGDLIEIYRDVTNVAPWLSEATIFGEYLYLGSWFNNYLARVKVEDLKYNSSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5I0</accession>
    <name>A0AAD2G5I0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5I0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="544"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="751"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1963480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="850" mass="95496" checksum="3712F45AAD7C43CF" modified="2024-05-29" version="1">MPHHHHHHHHHPYYDFDQMSSLIKRLDVIENEAPSLLQAFYEPRLKSFSIKPEIGSRKRVCVTSTCYALVQLAISKIYDITSGYGAVITYDNSMERGKGDEDNENVKIPIPKVVDTLLRCPFRESDLFQIPLLAYSILQVDDDRSMIRSAAKSDPQVAAKFKTMLSTVLKAAPDRKLGSNQVHSDYVQYQVCKLIALLHDYTIKHQSDDNNGSDDGYGGLPEEVLPDNIATDAFWVLLSCAEVSSNEVCRQLAYRVADDLGSFDVMRLAYSLLTYVRSTTSLSGMSGKEMVEGEGPSPETRIPQLNQKLVAAALAAFFKEQNIDGMWDRGQPIYKSLSRGKRRDMGNAFVFPVNIVGSLLQMLPAEAFRPHLAALDRTLQWIESHQRFETVVNYCDEETGNVYGKPMKGWSSPHLNPSSGPEAWPTAQVLKCTLWMRQTIRELVHNDVLEEFNGIAFSKQSDKNGDDWDTLLDADLGGTSPTSDENMDSYDLGGSSPTSDGTKDPNDSDTDSGGRNSCRTIKDVLEQRVIQPFAASIENPSYGAAYSAILFGPPGGAKTSLTEALARKMGYDYVCIDTADFLADGLTNVAARIRYVFNRLMALQKCVILFDEIEEFAMDRKLPSLSMESRMLTTAMLTAINDLRRKEQSIFFIATNRLDAFDSAITRPGRIDMTLFVGTPNLESRVTQFRQQLARVRHVRRSETSAVDDATGDRDGGEPEDSLKDDDVKPRKRKRRKRKEDDENQAKDSRDADDDDDADASDEEYQDPLIEESISTFRFFLQSVWSEDAMFMNYLEGVQFASACADLVSSHQRPPTVREMKMILRQQAAVMTVRGAAREEFLTSMEMSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5P9</accession>
    <name>A0AAD2G5P9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5P9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="171" mass="18915" checksum="47EFEBEBC1B2B3C9" modified="2024-05-29" version="1">MKHKRTPIIIEDYSDDENLSLGPLGKRQKITGMAPEALTLELLIRAGEALKEEDKHSELREEASRSFGCVTPTHEHQDKAEDAPLYHNLVQTALSDSLAALEEPKCTAAGSDSDSSSKDWRQYCRPLSAPPRLPNAPFGSIISQKKRAASDSYLSRAWRLGIAKDTHALSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6P2</accession>
    <name>A0AAD2G6P2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002193">
        <property type="protein sequence ID" value="CAJ1964655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6P2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="16728" checksum="AE79958118F4C684" modified="2024-05-29" version="1">MISYINDNGGWKIIGWCKRGLLSIKGETDKVENRNVNLRLTSVYPQNVGILDDENFKKLLIREDFEIPDSALTNLSPNPETTEDDESDSSSSNDDNKRDDDVDDANDQRPNPYKTGDNDEDAETQEHTDVDVTHEHDDKSEEENELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6Q2</accession>
    <name>A0AAD2G6Q2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6Q2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1965045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43439" checksum="3E6248EACD68FEE0" modified="2024-05-29" version="1">MAGRGEKNVAIVIDTGSGRTKAGFSDDEAPRTTFASLVAHPTTNWGPNAKKVVGQPAEGKWGVLDVKQPIERGIVTNWDDIETLWHHTFYRELKTTPEFYPVFLTEVPMNPKANRERITEMMFETFKVPALYMNTTAALSLYAHGRTTGCVLECGEGVTHVVPVYEGVVLVNAIVRLDVGGKVLTDYLEKMISDHGYTLQDHEMRNVTGKGLSLTTEVVHLQVRGIMEKLCYVALDFNKESIKVVEDSHNLEKKHTLSNGDTVVIGNERFFLPEALFQPELADLEEESVVDATFGAIMKCDEYMHEEMLSNIVLSGGCTKFPGFKERLTKEMAALAPNTLEVNVLAMAEPQNTPWVGASVVASLDEFQNMWISKEEFYKKGPSIVHSKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7Z0</accession>
    <name>A0AAD2G7Z0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7Z0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="78" mass="9295" checksum="3AF06AE782FD50C5" modified="2024-05-29" version="1">MSSPSSTYQEEQPLEQEQEQQHPWAQEDDLLARQCEDYDPWNQFWGVSEKKTRKFSDMGLFVVMFLCMSSAMLRIKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8N8</accession>
    <name>A0AAD2G8N8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8N8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.310">
        <property type="entry name" value="membrane protein fhac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF42">
        <property type="entry name" value="BACTERIAL SURFACE ANTIGEN (D15) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042145994" description="Bacterial surface antigen (D15) domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="75341" checksum="4E1109967B2A32BE" modified="2024-05-29" version="1">MLLIQLLVCSYFGTSNAFLTPPPNGPPSQLNLNFGDNDDGAHSASMPIIYNKDDGFRNGFDEEDAENPSDHTQSKSSEASDSLRGGAGGGSSASSNGVVRGAQVTSARVTNFWSSAWQNFSSKVSQVFKSKETKKEEELMEQLRTMPVQAVSLPKDSVVPDEVARMAVKRSGQLGQPLRTDRVQEIAKGIKRWYNSKGYVLHSVTGATLKPETATAIITVEEPKVSQIPVDITVCKEMIVDDETGEIMTFKQYRRKEAARKSFRYDRIEKSDLNTTFVITQGRTSAKKISQAMNLKSGKPFKWDNGRWQRILSSGVFGKVLNAGPARTRDGNVCLQVLATEPPPRHLEYGLGKSLYTGTWEGEIDFEHQNLFGGGETVGLVVRRGTTDAAPSIRIQYKDDKFGLEGGHEMEVFTDYIGDSAEDTSSKATTSSDGSDSADDKFVDYEHDDLFNRRGATFRLKNPIDPGYVRNSLASISAERTSTRTGLHENLASTSLTLGPFRQSLPMYARSSFSTTLTGGTRLGEADGENEGIFGYEMLPYSQGSVTSRQILPLLSITKGDSRKPISLALQHIVATATPNLPRHEAKAMGISAQIRGVKPDGGATSTVKGTAELRIPFELPKIGGDATMLFFGDWFYVQKDHSSPFYSKSSIGVGLRKNVQGLPLKYDVSYTSEGDIKQFFGLGMDFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9B2</accession>
    <name>A0AAD2G9B2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS22322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9B2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="108"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1966739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="720" mass="78127" checksum="B6C6E10F321442B5" modified="2024-05-29" version="1">MSGTVFVPLQILLVSIDILLSIVTFKWVGVIKKLLASDPVRSVPLKDDPSHRVHADFKEARVSVPSNGARTMYEIANNGFVKHSDKICMRQREFVGWKSPKVKEFSSKVHEWTFADVQKKAYSFGAALRANGCVPSDPSTNLDKIEKPCRMAIFENTCPEWMVSCVGAFSQSIGVVTVYATLGIDSVIEAVVDNLVPVIVCNKTNVKFLAENASRMPSLKAIVYTNDLIAKDDKTDIPEAPSGLKIFSFDDFVKNGDVVQYPVSPPSTDTTAVVMYTSGSTGKPKGVVITHATATGGVAAFDVAIGPTSSHRYLGYLPLAHIMELMVQFLCFGNGTSINYADPKSLTQTGAYPIGALEQYSPTHMVAVPKVWDTIKKGLLAKVGQTSPVAQVLVHTAIQWRTFAVKLGLDTPLFNALVFKKFKKAVGGHLEMALSGGGPLSGEVQEFIRVAFDVPLIQGYGLTETCAGLAIADEGDGRPGVAGVPIASVEVKLQSIPDVCDKGGLPYMSTDRKDVEGNPVWGRGEILVKGSNVTSGYYMMPDKTKEVYSDDGWFATGDIGQFLSDGSIRIVDRKKNLVKLKSGEYVALEKMEMVYGNSSFVDAVAGGICCYADGDMDRPVALFQLSKPITMKWAKEIGIPGDFETVKKSKDLYNAIMASFIEEHAKSDLSHIEKLKAATILTDPWTSENGCLTAASKLQRRVVVDSYPKEFEAVKKKGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA84</accession>
    <name>A0AAD2GA84_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="242" mass="28112" checksum="D5F9C64D15FAF6D3" modified="2024-05-29" version="1">MSLQLEEALFENNTLGYFNLHCGNSSQALNAVAHRDMVVEKLQQINRRAAKASDENTTTTMLMNAYHGTRLSGEMSYPNFKGDCRKLNYPNVDLLYQACDMAKVDCGHILIYRDPYAIMRSTNRRKFHNDSSIVAGIHMYTSMLSIIQTQLWTHSHRTLGCWSVLDPTEDVWQSIQRIFGWESRIEMAKAVRKIYWNPKPLLEEEKELIVPTIYAPYMDSFLRHHEDSVELCRQQAEANTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAU4</accession>
    <name>A0AAD2GAU4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="780" mass="90104" checksum="277BD29E5596CD1E" modified="2024-05-29" version="1">MRSMTTSDDEVKKEKARAEWAKFEDVTQLLQFMEKFDTLYDQLKNSGSMFAMGASSTGDTLPPRHNVTMTEEIWNSLSLHDQYNLLANMSQQTEPHFDSLIRTIQEGFGVQVNKGPMTMMQGQVTERSTNDDFQNDIRRVIDLFRCGTSIVVEDLAQIRNMLDWLRHGDLAKDWQVNHVQNGFEKSEAYLTYGYRDIKVTARCLRTGYMIQIEFHLKSYHELMQDQGLKHYQFAQQYPFQPITDASQIMDMNLLPEIVDVGVEALNTTAAMDQKEKTAEILLRLGNLKLRQAQMLSDDDQSLQKAALASKAVYYFDQAIRILTQTMDGIMKDDTTFSSRVIASIYCRLLIGLSQALCSYDWSIYYAQRYHDDVEKRVELPNILFPEMNFESIHYGIQMGLAMAISQFDERHPITLYAKYVKADVMVGKEGRDYVAELVQEQQRVLGYNHPMVFETLISRFIKVKEVWATMDALNEIVPVFEVNLNRLGIHHPCVMRLLLYLCVFFQTEKNSFLIDAPGSEVKELVRVLSLDKWGGEEEVSVVSLVKYALIKTVHSPDASKLQVGARVAVWSWEYQNYWSGMITETKGDVCHVQYDLPENFEWISPLRRHTLLLSHGTHEPTSVIPQESFNSNNNNNNNNILDRGGVQVGNRLLLWYGFSDNSFYSATIDSRDKTEIEVTYDTNEHQVLALDDDLPDYLVTTRNDQGKVESVKEGDRIYVYWDVHKSYWLGKVLTVAEDDDKEDNMMELHPTKFWIQFYSGDLHACDLSKMNFYPEDHALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAU5</accession>
    <name>A0AAD2GAU5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002252">
        <property type="protein sequence ID" value="CAJ1966078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="630" mass="73578" checksum="261B91A458F81802" modified="2024-05-29" version="1" fragment="single">PTPEAVRDDWVEIPRELLVHNIDLNLHLDIAFINNTFGLTTIYGSVRYRTFVPLRSRTAELLYDAIDHVLRIYNHADFTIKTIYCDGEFRPVFDDVKDEMNVDMNYASRGEHDPTAEQNNQHIKALFRVQYHRMPYKAIPRIITEAIAKRVAQTSNFYPAKGGISAYYGPHMILLQRQLYYSKEFVAELGSYVHGFGHDTRSDHWSRTIEAIYLGPADNMQKGHKLYDLNTKREVTRPRITVLPITDQVIKLVEAHAGEEGVSDLRIYSRRNGEVILDADLLAGVDPDELWDEDYVPADIEIPPPVNDVNLRKNDAITDEELEELIKDAAEDILESRRIDGKRQHDYDETDRTVDRMLQRIKRRQEEDDEDDMDFVQDQQPESDISSVQDQQPENDIEMDVDDEELKDMIDEVAHELDRLSQPIEEEIMFSVEDEDDDYEGEYDAEEIQVYPDEEDDVCAGVRFEEVPVLSTTNDSNKDKKRRTPSGRSFYSNGVKYRPTDRNRTDRPRYGQTYLQRKKPKINLLKNRSAMRKKARLKRLRISLYQAIASKVKSRKKEEFWDDDVLSAEARRKITERAHNLMFQQSGTEKKATYNVDESLVISSVMQQIRDEVYTRDRVSFIQQYILTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAV2</accession>
    <name>A0AAD2GAV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4246 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002336">
        <property type="protein sequence ID" value="CAJ1967580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAV2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="464"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="844" mass="95151" checksum="24764B05ADD05C79" modified="2024-05-29" version="1">MNVPEEDNSQKAKRKAIQDVMKDTSLTPQQKQQKILKITTAARSNKTTIDTSNDKKAAPSALAAAPIIPESAPSPTAPAQIAPPSSSSSSVSNKTTITESASNTTTAKASPSITFKPKSLSSRGTEMLNNQGALIAKIFSFVIEDTKGLADLRLVSKEWNANVRLHVLQDFGFRKICAATRNNYYFCEELVKFGEGSFAGRNFNKFGSRSLFDFKFFISPKDEQTEGNGDAEDGDMANGDEAAWATTDALLFCKDDGGYGTQRKKCVIEKSDSYDFLKDEASRFANYCQRITETKSFEDFVTMADNGITEGLFLCLQDLEHAKHHEITINMSKDDYDTHRPVILKLRLPSNHGAKLVEIGGSKIVYLKVKIEMEPEDDTELDCAYPFVDDYKNPNLTRDETHIYPTFVGYNVKENEGGGLSCQVPMTINFNDGLAEEMWEWGAAESFLPLDILWSKCQEQPVREGVAIADDFVPKTLHINLMDQIGLLLESQAVDYHPHSNNIVRDIVHPALYSYVKGVSSLLKSEEEIKALSFDPSIAEDDRIELEPNDYWGREYEASAKYQWLPTYFDIAEDGSCIIRDYINNLVPRSDHEQLYGSLGQLFSQALPLIESVYGYCRVVKEDHIRDEEDDLDYNPKPAGPIEERPVSLRGKQLQVITKIVDYELGPGQSYEGVWHVEGMSHEEIVATAIYFIDRDAEIEGGDILFKRAFHKQEARYIFSSVDQTRPPELEEKISDGLLPLGQVETLAGRLLVFPNSHVHKVTELKNTSTTKDTETKKKRRIIVFFLVNPERRIVSTKEVAVQQEHAGGSMKRSDALEHRLKLMEERKYTKQDWNVREIELCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBU7</accession>
    <name>A0AAD2GBU7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002402">
        <property type="protein sequence ID" value="CAJ1968698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBU7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="281" mass="31215" checksum="AFA10154557315CE" modified="2024-05-29" version="1">MPKSTQARLQYHDFHCGHRGGLAPSPSTLQSMRSTTNFATSMSAPPRMVSFEDGHSDACSSSSSDLEHVLMPLHQSAEQHSNSEQTRGEGTKEVRLCRSTSSHKPRLLARHMPSLSLVDLANTLGMDDANRESGLLSPRRPHSAPVSPVSGVALDPQRCLVSTPTSSLLPPAMESSAEPWGHFVDMALPDKQLRRVLPNKTVPLSARASGKSNNRKRHERRANPYGDYYKTKHPLCFQPNKSRPGLDFVVPFSESLFQLQPRSYKEPAEQIVGDFERLHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GE66</accession>
    <name>A0AAD2GE66_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002471">
        <property type="protein sequence ID" value="CAJ1970175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="573" mass="65107" checksum="EF5797C9587B72A3" modified="2024-05-29" version="1">MMLFQHNNTGTHWDRGYTFHLRTNEDDLKEGSLQGIHGGFHYASNVKGRELYREGIDKVFDSVCKLDTQASDNINSLSNMVQDGFDVFMDTKRDNSFFVTRNGTTWQFGHRNGLYTLVDEPAMVTTMFHDHARGLDNDDVQGYCALQSVEKNKEGFTNKQVKRANVARSGYHMMGAPGAELFKLAIRGNFFKNCPITEEDVNISEKIYGPSVSTIKGKQKRPTPKAVVDDWXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXILRIYNHAEFQIKTIYCDNKFKLVFDDVKDNMDVTMNYAAPGKHKPTIERSNQTLKGLFRAHYHQMVFKAIPKVLTIALLKHATKLISHKGGNFEILQSTYDCEMKTGGFSKECVAEIGSFIQGYGHTTNNSQRSRTIDGIYLGVNDSIQAGHMVLDLNTKKTVTRPYVMVPPITKQVIKIVEQMAHNEGVRDLRTYHRKNGEIILDGDLLAGVDPDELWDDTYIPCKNEYKQSDGNLRNEKIDQDEVDALLEEAEEFIENYDNENTKNVEEQTEDRSVASIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGP5</accession>
    <name>A0AAD2JGP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uncharacterized protein YfbK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021908">
        <property type="entry name" value="YfbK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12034">
        <property type="entry name" value="YfbK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uncharacterized protein YfbK C-terminal" evidence="1">
        <location>
            <begin position="109"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="221" mass="24524" checksum="B7B736CC50562861" modified="2024-05-29" version="1">MYPSSPIPGCPELLFSQHLRLNRKTIFGVIKSLRASGSTHGSDGLELADRLAGWHFEEKAVNRIMLFTDGDFNIGLTQGNALSRYISEKRSAGIFLSEAQKALVQEAQSTLYTIAKDVKFQVEFNPNRVAEYRLIGYEKRLLAREDFHNDSADAGDIGAGHTVTVLHEFNPVEADLTASVVDDLWYGIANGAVGNHKKSPQPTEKAPLDNEYAFLKMRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHG2</accession>
    <name>A0AAD2JHG2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS13001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHG2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1951292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="229" mass="26209" checksum="83008DB756A2CE9F" modified="2024-05-29" version="1">MAKKKQQQQPKAAAVPSSENDELEDDDDESVEDVELELLQVDLGDMIKMKQILDETVAAAIMERLEEDHRLDNIKLSLMTAACLFAMVAQFAPVPFPDSRPILGVCCCCYFFLSGIMQLITTFIDKDSILLTKPISEATKKRGDKKPSLLQKEKIRVRTQFPRFSEFYTLILEYQEEPEKKPMVEAKWSVGQFFDEEGFFDEVGLQKSVLSLLTRLEKGENDKKKKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHL3</accession>
    <name>A0AAD2JHL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHL3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="293"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="441"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1950047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="62108" checksum="A82EED71E862ECDA" modified="2024-05-29" version="1">MGFLQKAFCAGPQRQLTHANSQRPNEYGFSTGGEASNECDYDNNPTQLYQLLEMKSWSQAMDFLVEGKYDSSTIDNNVCRIPYNKQVSVWVTRYDRNGIKIRWSHIPLHAAVIFGAPFTVIKKLVELYPDGVRCADDQAMLPLHLAFKHLTNVNSLRLVMNEFPDAIFTKDNRGRLPSDIRDDEISIIIQRVISCATSRIKQQTEDRDTKEITELRKALLEQKREAQVDDGVARRHQNDLQARDATIEVLRSQLEVLRFELQSMEKKSTYSFPFMQSAGHDSNGEQGYQLRRGIELEAENEELKAKVNALQKELTAMNTALQNQENRKNMIRIDDNDVHRFTELSEAMVSERNKYEQEKRKNNVLAAENERMKEEIARVRASVSESYRLSDYVESGGNSGAENRAPTKERFVPQERITSLKMAPVGVGSKDLESFLETRLLKELDIENRRLEKQLAANNNVDVSALLNKQSRLQEMEREVKHFQGNSQRIFGGGVLTTAPQQSTIKRYDEDDHSRRRSNDDAFVDEYNRVRKQASGAYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI21</accession>
    <name>A0AAD2JI21_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI21"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="288" mass="31782" checksum="10F62464C9E78806" modified="2024-05-29" version="1">MSFLFQEREPHDDDQSQIRSNPHPPRRQEQANDDEQDADGVVVVYGSTYTYDEELPPEMTTKFGGKVAIEVSKLQKKIKQDAERALAFTVEEARKAMRMFSGSLEEFRNTSSNSSAVSVSPYVLAVLEAGGTVSMLVALEKWYKKSEECSLLAMGGLATLVVSDPSSGLTIASIGAITTIEQVVQQYPKSQMVSSDAIEVLLSLAGQVVTRPLVAGEDCRGLVQTAMAQFPMDEDIQLEGCEYFLEIGKLDGIKEDLLQEKKLGKLLGHALDQFREDISKRAVQWYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JII1</accession>
    <name>A0AAD2JII1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS14306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JII1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF33">
        <property type="entry name" value="STROMAL PROCESSING PEPTIDASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041998101" evidence="7">
        <location>
            <begin position="21"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="120"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="273"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="877"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1953703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1198" mass="132720" checksum="EDDF070B9354ABF3" modified="2024-05-29" version="1">MKLSAPISLCLGVVVFSTAAFQPSFSFTPSQRAPRTKLSPVVLHQEGKGSFSLANLFGESGSAGPSLRGSKNLEPHPSVRSHISPLNRLGPDEKKEVKSEPLPFHSNVKSGTLPNGLPYVILPNKSPPGRFEAHLQVFSGSADELESQQGIAHLTEHVAYMGSRKRELLFGTGSQTNAYTDFHHTVFYAICPNTTPRTNIPMLPMALDALVDVLEARVESSRLEKERAAVLSEMTMVNTIEYRVECQILSTLHRENRLAKRFPIGKESLIRSWQTDDVKSWHRTHYRPDNVLLYLVGDVDTEEAERVIAEKFGRLSAEKQGADIKIPEIKEQAKDLADAVVGGTVKAAGSWHYPPVRHDWNIAKDMDVDGKLIIPKDQLEYDINLQNSYPLDETVSFLQTEEVAPGKKIRPHIFRHELLQSFSMHLFAKRPVEPIIDLDSFRKSLARRVALAALQIRLNVGGRSDDPAFTFVEFNQLDSAREGCAVCSLDLTAEPHKWKEAICKSLSEIRKLGVHGVTMGEMERYASSLMTDAEQLAAQGDRIEHGDQLSYLMETVANGHTFMSPEQSYLMTAKALSSLTLEDVNSAAAELCSHVMSFKEGEDPVDGSVVAVACLPKGLEKDDPAYCDEDSLVKAIYEACQLEVEPEEDVVVPFTLVPEDELVKAMEENPPDWLGGQFSDGTPNTAPDTITRPFTLRRLGNGIRIGVNQNPHESQRGHLRLVAPGGRDAEKRLGFKKGSMAIGARTMQEGGAFGPWTREQVELFCVDHLLMVEITCNEESITVDFVFPTTNVGNVGFGDDVQLGITGTESVMQVVREIIVGFKWEEDALGRSKSSFRGTHESMLKNLENLSTEKIMEAMTADDERFLSIEVDEVNAITLDEAKTAVMSQMSPENLEISISGDFDVAEVLEMIYKYIGTIPADANKEYLVEEVPADVKGAVVSSVPSLPLPGKFVELELPDSDPRAVAYVSGSAPNAWGYLADGRTVSEIILEKDKRASEYDLGRRKHPLFARIALLLLSEIFNRRLFSNVRERKQLTYDANFSFTGFERLMGGWFLVTVTASKENAQKALEACKETLHNLRKTNPITPDNAESAKRVVLNRHEFSLRTTQYWTEQMSGLQEESVPLKGPLSFTDFQAVVEAITVKDLQLVLETMGLDDNELYTAIGKTVKPDGVEEPEEELVRQAPVIGMRRGGALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ59</accession>
    <name>A0AAD2JJ59_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ59"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="396" mass="43953" checksum="FFEEBC0C1F00AB36" modified="2024-05-29" version="1">MTEEMVPKQFAISLVCLALAGAFDNHFWRLVVLYVHHQLWILLVPTSGVVGLILQVVAMVGIMWIPMFANFNYRKRQGCIMVTGCDSGMGQATVVHFAQTNDDSKKGSFEKIFAACYNAQASKEYFEKTLTKDQLRHVLVVPLDVTDDKSCKDAAKTVQSWITNETSSKGLYGIVQYHGVPFFGPACYMPVEMYERQLQVNFLGFVRIVQNFMPIMKKRSMTPGRIIFTGTGGGPCSPCPPLLSAYMSSKFAAESFVHSLRAECYMTRNEISCVVINPGFVKPTMLVEKGIELTDKMWKICEDKQGSTVAKDEYGELANHFTKYSSLQPGTHVSEVTKAAEHALLSNVPRTSYKVGIDSKLAPFVGMMPTGMREKIAIHGIYGILSPAGTVKGYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKM0</accession>
    <name>A0AAD2JKM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="4">
        <location>
            <begin position="560"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="4">
        <location>
            <begin position="964"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1959389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1254" mass="141537" checksum="450423393D11E4E3" modified="2024-05-29" version="1">MRRTGQTFFLCYLGIQTWLLFEIIVMITPPAVVHGFSLVSSPRQQITDAKWTMTPSVSLSQAIEPSSDVPESSRDEDSSTTTMTNIQMAAWCLSQQLIMVLQREELSWRIQQEEDDDDDLQSMGRIANKKRKKTQQMIRWLNTRLLFGCTALEWVQQQAASTTTMDYDNYDYNYDKIGEDIQEELQAMLDFSEFSSPFLDDEGGEEYFDCDDNFAQEFGTANNVSSEDERELDSSEAQMDNVQEESQSGASLPIFDFGKPLEIVQSDVPPLRNCYPMTAVTNTDSSNLRDSRAIKILADEEEYSRALLFHDRDTTDEADAMIEHQEDDKEDDGLWPETSSSIDFLDDQPTFETSNRYSIKQTPEIQSNSNMEGTITEPLTPQIIPMNDDDDDDDDDDENERLGNGLDHHQQHQQLILEATIHDIDVTEGKDAMPANVLTKQSEEMDSLVVQDGPVVDEEPSSISTSSALSHADKMKLYKASAVIAHSFPTNDFDPPIWTRNGNLQTIGGFLARGKNPALVEFEWDERKRMETPDGDFFVVDWKFSDLDEHVGRPSSEVPLVLLCHGLQSNSDSNVAKDMARAFNSVGMDVACINFRGCSDEINRGPLGYHLGFTDDLKLMLEHVSQSRNGSKLYLSGFSLGANVVTKLLAELKTDALTKYNIRGAAVNALPFDFLKVGPNFSDEGLTKSLYGDGLLKSLTERVLENYDDQNYTFSKEELMDCKTLREFDDLVVCDVYDFDGVDDYHRKCSTISVLDQVAVPELVIQALDDPFFQGNTNPTNNPSQPLRIQYTEHGGHCGYWRNEGPDHDATWMPLQLAKFLKHVDEQQSSLHALYDVESEGHDNPADVDDTRKQDLAEERRQRAALVSHSFQVKDYRPALYATNAHVQTVMGALYRKETMYASSDLPSFLSGISKFKGAVGGDGFQWENFHWDRRQRLETPDDDFFDVDWKTSGVNFASDDTPLVIICHGLQASSDSPLVKDMAEAFLGHGMGAACMNFRGCGGEVNRTPRGYHLGFTDDLHQLVTHVNTVYPNKRIYLSAFSLGANVVTSFLANLGSDAQKYSIAGAAVNALPYEVSKSTMNLNSDGITKTLYADRILESMYERIEEMYDYGIDFPFEREAIRDCKTIMDMENLVIAPFFDFEDAWDYYDKTSTLRRLDEVAVPELVIQSEDDPFLLGQSHVANKADRPLRIHYTKHGGHCGHVFHATDHAYPTSWMPTELARFLAHVDLSLKVDKFAFSSQYNQNTEKEILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLZ4</accession>
    <name>A0AAD2JLZ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042206852" description="SAP domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1961757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="217" mass="23602" checksum="AEBB3D2CC753E519" modified="2024-05-29" version="1">MRQTCLITLLALVTSFASVNGFILPSSSPFTSTRLYAELPDMAKMKASEMRKELESYGISTKSLLEKSEFVEALKKARAEGKTPVNGTTDASSSASSSTKAESSSSSSSTETPPESSSESSETRDKRYKEALDKAKKMKVGDLKKELEGRGISTKSFFEKPEFVKAYAEAVADNKKGKGGPGPRPEEPRDPAFKDVVMQKMSKGAMMGERVIDIMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM07</accession>
    <name>A0AAD2JM07_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="104" mass="11082" checksum="2F8DB23F9A2D673E" modified="2024-05-29" version="1">MNNQSSSSSACSSSANVNSSRTNESSSLQGPSLRSLRASIRRRSLPNSPPMFSLAHPADRPIRNQREILNAALAVIHADGDLVAQLSSSSSSNRKLQRGGPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM82</accession>
    <name>A0AAD2JM82_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002167">
        <property type="protein sequence ID" value="CAJ1963912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="305" mass="33691" checksum="9C4937BB1DF8DA83" modified="2024-05-29" version="1">MMQVPSGMQLMQIPTQGGGTVTVPYSMNANGEIVFSGMQLSQQGFSGAQVCQGFDATQAQTPQVVKTGYYDMSNVFHNAIKGKDENGNDVYLIPCPAGTTNVELQANWHYASDNEDLPDLATEADRGLQFIQSRRKERDPFGLYNHVIMDSGCTNTTICNGELMHGLRHAEKELDMHTNVGSRVLDKEGFLGRFPPPVYHDEDGIANVLAMREMIAAGYRITMDTDADNAFIVHCDGNRKMRFVNCKGVYVLEQLGANVKPGAKETSVMYRRQLSNLNNQPHFELSSNKQNGYAGLEMTSKMATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMI7</accession>
    <name>A0AAD2JMI7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS20888</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMI7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044600">
        <property type="entry name" value="ATL1/ATL16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913:SF1">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1964977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="258" mass="29973" checksum="46B1B84BAD24A5F4" modified="2024-05-29" version="1">MTEEEKERLEDLENLLPCILYYHRTEQKDDDDNDETMTRRSYSLYDGFDKEHRSLSLRLHQQECSICLMEYEDGEKLTSSHNLNCLHAFHRDCMKKWLVSNSECPCCRKGFLEFGDNDEGADDNEIDTISPLIASRFALLATTFQQQVGRMRQDIENQLEPIILRLEQQHQNETIDPPNANHHQQRRTTRNDTATQYDESSPYATGSSSIIQQRMERIREGLSDQFVNMMVRIEQNGNARRGAGDDNSGAGDDTSWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMK3</accession>
    <name>A0AAD2JMK3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS20933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="271"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1965069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="504" mass="55715" checksum="B182896A4E038179" modified="2024-05-29" version="1">MEIRAKSDHVCRLLKAATEGDIEVLKSASDDELRSSVCNSGCTALHWAAGTNQVTALQYLILERKLSPNILAVKKSKGRTPLHYACRNGAAEATRFLMDDCQANVHALAKHGVSPFQLAVWQNQLGICQYLVEECGVDPCQVNDFDCGAIHWLGICPVNRANNNTTVSSNGEKCTDKDDGSDLLPLAKWLAKQPGLDYTAKQKQGHTALHKASWGGHISLLRYLKEEHGLWDDSVDDAGNYAADLADMANTTRHTRIAKYLREECSRARAESCSILGIDASCSSPSKIRQAYLKKAHELHPDRNGTVLVDDDQNEDDVTDRFDAVRKAYLHLSEHQGHGTQSNPAHSLNLMLQVSGLDDTDTNKDNKDNDDNDDSEEAGTTNDFVISNSEENCFKARLIAVLLEYGDKGLDLSNVKRKWKQVWPKDPFPEPVAAARSHRGRSSKYSTNNQKKKISMKTFLEEQAGDVVELVQDGSGIRVRPKNCSQQKVALHHNAISKNDVASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMS3</accession>
    <name>A0AAD2JMS3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMS3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56047" checksum="7B9CEC0517099666" modified="2024-05-29" version="1">MMLKGKLDDQFFDIADRVPGSCDDSEDETAMQEYYGCVFPHSTMVLYSRRTGAPLAALTLATSDSNCQSMITRRPAPPEGSEAYFQGMLDKEGAFFEFTISNLSYRGSINFNILHTPYRVSATNQGPSFGMNEVNELSPNQSYTVRANQQNNRRMCLRGKTKTIQDHHSTVQCPMSVTEAESDTSQQGLYFCLSVAPEASCPALVVLFSEGTVWKVADGFTREVPIPKTRRSYRSCLPISPKRPLESGSLSDWSINTTRASDSAAFSISSRQRRSKCPLERASMKSIGIDNTVIPIPRPERRSMTYVDDHLFDNPSRSSFSRASMTSIDIGDMFASQQSPRQRQQRRNTTMQIPIDIGHTQAADLDYGEEIQIRSEGSSLVFDFDKASDPTVLCMSIWKEMSQHLLVNDDRHGSPRRVNSRESPGNLEQSRNCPALQSFEDEAIEYQLNICMADVMSPVDTILIPCGHQCFHSGNLNHHNITHCPQCRTQISAIMPLSMTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPA4</accession>
    <name>A0AAD2JPA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS23690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050428">
        <property type="entry name" value="TCS_sensor_his_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45436:SF5">
        <property type="entry name" value="SENSOR HISTIDINE KINASE TRCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45436">
        <property type="entry name" value="SENSOR HISTIDINE KINASE YKOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042061058" description="histidine kinase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="420"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1969402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="595" mass="65575" checksum="AB6E2CD1EB365EF0" modified="2024-05-29" version="1">MHYIRGVRIRTVVRVVACLLQLASTNPFPLHSSASNNGFETSATEFDDLSTNERPPIPPMPSDLFRKMAQSQLEVLANALNRPENSSESKVESMALYLPQENVFTGQLEFTPVVVYPDPKSERVFISYDAGSGKAPTLPRALTKLPGFSHAATLLPGYPMISSSGDCDPDVGSVEEVMCDPRFKYGPPALSVPLLSGPQTVGVLLVSGMTEPTKKQFWSENDRRQVSSAAQSLSMALTMDNERSILREQNQMFKDSLSDSLHQVKNPLQALRTYGKILQRHMADADSFRGDDMSSPQLLELVERLMTQSERVVDLMIPMDTLVNSFDQPGPYILAPAEKEPQPQPLVLWERRRKVETVSTPTNKTFEFDVNKIENNTELIGSLFLPRTINTTSRSDDSRKKQKVKTKLEPNQSSNAHTTVGDVETEMVFVNDILEPIISAFEAIASERNIDLKVVEMDPELPGVIAAPKSLQEAVANLLDNALKYVILPKSDSPFTSNPSPKVDIRILANQDPVGVTVLVEDNGPGISETDAEQIFQRGFRGEATRSVQGTGIGLDISQALVQRMGGDLQLASHEDYPQCLDGTVMALTLYRAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JQ07</accession>
    <name>A0AAD2JQ07_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS23625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JQ07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042148114" description="2Fe-2S ferredoxin-type domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="4">
        <location>
            <begin position="69"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1969278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="134" mass="13904" checksum="15124AB0E88DAD79" modified="2024-05-29" version="1">MSQSKLVFLFAVLVLCSTSVLGFSSPQLKIRQDTSLNIFGGLKGAFANEEMGAKKNEGLSNGPNINDNVTVNGKAVQGAVVGQKITVVAGRARVKIPVNCQKGDCGTCMAMVNGKKVKACQTALGAGKCTIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU05</accession>
    <name>A0AAD2PU05_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="903" mass="100185" checksum="597D45ABD66879E4" modified="2024-05-29" version="1">MSLLNTGENFDSVSPTPRQKQSVQIGSRIKQRIEAPGSNKKRSSFARKNRRSNNNDDGSADRTQPIIPIGRRRQGSDLGTMPIMFEVDEEESSMSTSGNKDLQSSSFHTARSTSRSRSLSRNGSSADEDDYGADVIGGEYSEDYVQLDTIQDLSESQTDNLKGSSGFQLDMVPATPEHRIRAVLTAGVIDHSGTEAPRQFPSLSLGDDSEEEGDDDENEAVEKRESEEEESESSNYEVESDEDDEDGDDDDKDDDEQSDDDDEDEQSDDDNDDEESDDDDADEGSEDDEDEGSEDDDEDDDEDDDEEESEETSAEPSESLDEDSNENSSSEFSSSVSSPLQQTTPPPRTRRRTPLHDTAMPFESSATAPTSLQLDSPPAHSTVQNVQNRDQDIFTNSIQLDAPPAQTRQRARSQDRMPSPIKATVSLQLDAPQAQTRQRTRSRDRILPPQDKFSNSLELDAPPIQQRQRVRSHDSHEDMGGTSSNSLELDAPPTRQRQRVRSNDTHEGSMSSSLELDAPSIRQRQRVKSHDSQDTDEDEAADTIADLPMPAPRTRTRTRARQQQPNRMISLDAFAVGNRSDTLQVDQTAPHQQGSGKRRMKAPARIKSMAPVSHNLPQQAPKRQMPPERRLSLDSRRKVYEDDNRFNTIPFAQRFAGKVQADSSGAASGAPSDGAPNLDSSQKKLEASPDAKNRRRLRSADDLADLMAPELESETSSGRARLSMFKRRVSGGGDDSPRREKAAYLLGMHKGSVALGRELESTMRSRSPHRVPSSMRGGGPMNTRQPRQRPAPNRFKPLKPPPTNDDLDMDDMAAIRRSSAQLSRRVSDESADTIGDGSVETMELGQAGLHRPNRMKKRKNPSDRSLDVEQKDPTQLDEKQFWLIVIFLTSLGVIFGFVAVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU71</accession>
    <name>A0AAD2PU71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS11617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="7">
        <location>
            <begin position="178"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1948439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="278" mass="30703" checksum="D2315FEECE11ED43" modified="2024-05-29" version="1">MTAQDSSNNSSEGSSSKTTTSVYSQGVTTKLASMNIQEATMDDKVGLYWPRMIMILLGPPGAGKGTHGPQIQQFLGIPQLSTGDMLRAAVSAGTEIGKRAEEIMKVGGLVGDDLVVGIIRDRIRHDDCRSGFLLDGFPRTLAQAKALDEMLAEEGSYVSKVIELRVPDEVLEGRIMQRWIHKESGRSYHIKTAAPKSMKLDDNGKPIPESMKDDMTGDQLIQRKDDNVKALGKRLQSYHEDTVPILDHYQPKGVVRTVNANQSIDGAWEEIQIKLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV18</accession>
    <name>A0AAD2PV18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS14279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV18"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677:SF59">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="116"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1953676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="333" mass="36307" checksum="0915C1A2950BBE84" modified="2024-05-29" version="1">MTAMKHIKLSQTTSTDSGDIDAIQCDAAVPLEPEEESDHHELPAPTEKRRSTTSMVIKITIGLILTGLVLFVLIDSMTNKRIPEMKTRMLTWCEENPLEGTIIYTVCFIVGVIIMIPATVFVVAGGFIFSHVYGFGFGVAIAIFVSLIGTAVGSTSAFTLGRYLFKDCLTPSVQKYKLLKVLDRAMDHHGFRIMVLLHLNPVSPFGILNYICGSLSISGKDYFFSAVGTTPGVILYCFLGASAQNLTALEHAGKDRTATIFTIVVGLIAGISLVKVMGNYAKKELEILEVQYALEEDGAEENVRPSTVLSTDEMDVEVVEQRSQDEGDIPTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV72</accession>
    <name>A0AAD2PV72_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV72"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="359" mass="40676" checksum="07A90A3288853F22" modified="2024-05-29" version="1">MIGIRVFAHCQVLAEVDLSATAIKEIPMCAFEACSSLQTVSLPRSLERIGHASFMECTDLVTIIVPLDSKQPIEIEETSFQFCRSLANLVLPRGSTKVSMARYNASPGPPLLQDRFGEDMDSVIAGLISRFDDYPLHKCCYDHSSTTTTAQELRLLIGKDQGAMEASSLVDAFGMTPFHILFSTISPRRDLLQVLLDKLPCSGIILDWKDANGKLAVDYLLLSNFWNSDDNKMILFQMTIQAWMVDRLERWGATVWRSRMISLIDNLLVVLLLPAEDHDKERRMTAFRETLWSTWKRYEAVESTSILEKALWKRTLKSKWNNDNALDRNGYRVICGAGFVIPKVLQFLDTPIGSSRRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVK5</accession>
    <name>A0AAD2PVK5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS15800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVK5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF205">
        <property type="entry name" value="ZINC TRANSPORTER ZUPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1955543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="414" mass="44869" checksum="0796845DC7543A01" modified="2024-05-29" version="1">MASPASISQQHEQDDEEWMFPLLLSFMAGASTCVGAAIVFCFDAKQIEGSMTFSLSLAASVMITVSVISIGPECLENIFVWQGAHLTFDVWLLVERLLSCGAGCFGYWLLSKALAAFPEPESFFVKSPATPLENTASTSYANHTTPRHSDMVDDEEVPETTSLIRRSTSGESTSSNASGRNTPQQKDKSSTSSSSKNPRSSPPSSRMRRTPSKTPMDTSVEDIDSGDKYESKRTKEEAASKKRSWRVAMLLFFSLLFHNFPEGLAVVASTVESRQLGVTVAIGILIHNIPEGIAIAVPCIAARPDMPWLAFWLASGSGLAEPLGAVFALFFLKSSKIPMENVLSCVAGIMCTVAFVELYPEALRHVPSESYSGSSNEPSSSSSPTTTTRKDYSQLIYGTLVGMAIMIATEWYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWM3</accession>
    <name>A0AAD2PWM3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS19130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF56">
        <property type="entry name" value="BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1961303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="540" mass="61641" checksum="C4BFDCB48BF3D1B9" modified="2024-05-29" version="1">MSFASQRRSTVSKNNKSATKQTHQITGRRRKPKQNGLGGLPLILRLTLIVLLCVIILTAAVLLRYFLQKCLLLSKNSPLNYSAVEKAKFYGLSQRKMNSGQGDASFWSNLSNATCDDQGAYEMLELGEIQRLQLPRAILIGVQKGGTTALFQYLDQHPSVERTKKELYFLDEDMDRLVGHAGTIPRKVARNLYHQKMRDGMVEARALEKQKNRHMHQLKQKLKQNGGAQLADSSLADNKQLRTRRLQQTDKLLPIVHGEENTQQKEDLDDGFSRSHHGPPPGDGQIKPIKKKTTPAALTTNKFVMDLTPNYMFHSDRVPNRIKCLVPWVRLLVLLRDPVARARSQYQMKLQMVLPKSHNSYGNPIPSLDEYIENDLNALEEVGVLKNWTEVDFESFWKSEECWKAWQTYIHKGLNAPVGMGLYALQLKPFLDVLVEIHHGSLELLASHGILSDYFLAIDSRDLQMETDKTYQEVLKFLRLPSFSLTEYARVNKASSKDHAQLKSKLSPAIQKRMQDAIAPYNRKLGDLLGEEWKDKWTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWP0</accession>
    <name>A0AAD2PWP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1961281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="368" mass="41524" checksum="AC8A65DC7BFD96DC" modified="2024-05-29" version="1">MNRQLSGVKSRSSSSKGFDLNGSDDEYDDVDLGNAGWASSSNNDGDVVQQWTLRIKSFQDLELQLPSNAIVSDLKERTKNALGDRAKNRYMRLICKGRLLSPDDSPIQDFNVNDGDVVHAVLAQPQVQAQQRRDKRDHVVDANTTTNNTTTTNNNSDGSTLQRRQRRRGRDTVVGPGGRVTRAQPPEGEDWGNSSSSEDEDTEMGRERLGFDRLRGSGMSRSEITAIRTYFSRQVDRHIEQHPNSHDEEPDLRRRRFLMEDDWMALQGPASEFRLNLNQSTLLRFTTGMSGANGIGGRNLRVPARTMGTSRDFYWGFMLGFFVGFGMLIWVWVPSIPHKQKLGIMTGITMALALEILQDEHIDEFDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXR9</accession>
    <name>A0AAD2PXR9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BspA family leucine-rich repeat surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002336">
        <property type="protein sequence ID" value="CAJ1967582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042078707" description="BspA family leucine-rich repeat surface protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1176" mass="128363" checksum="4A230648DE06E649" modified="2024-05-29" version="1">MVRVSSLFVSTILWCLMLAPSLTTSASSSSTFSCSNDDVSAQQQVNSNGCACFSEQIELREAVNQFISEGCSDTNNCNNWVVQKYGWPMGSWCVSSVTNMFQLFYGRSFFNDDISSWDVSSVSVMTYMFYQATSFNQDLSSWDVSSVVSTSSMFEGASSFNQDLSSWNVSAVGHMGKMFHQASSFNGDLSLWDVSSVTYMYWMFYAATSFNQDLSSWDVASVTDMGAMFHSASSFNQDLSAWDVSSVKQMYWMFQEASSFHQDLSAWDVASATDMQCMFYGAHLFNGDLSLWDVSSVKQMYWMFRDAPSFNQDLSAWDVASVTDMAFMFHDASSFNQDLSAWDVSSVTNMRQMFSFASSFNGDLSLWDVSSVLDMQYMFNEASSFNGDLSLWDVASVTDMASMFYSSSSFNQDLSAWDVSSVTDMAAMFYSASSFNQDLSSWDVSSVVNTYSMFGGASSFNQDLSSWDISSVTDMQFMFYRASSFNGDLSSWDVSSVTDMAFMFYEAPLFNGDLSLWDVSSVSKMGSMFSCASSFNGDLSSWNVSSVVNTKNMFDGASSFNQDLSSWDVSSVTNMAFMFKLAISFDQDLSPWNVSKVKYSEGIFQGAVALDECIVCQWSDAWKRHFNCIGCESPTSAPPANATLSPTNAPFSCSKDDVSAQLQVNTNGCACFSDDAELREAVDEFIRDGCSDTNNCNNFFVQKYGWPMGSWCVSSVTDMASLFDNVSEMGYLFNGLFDFNDDISSWDVSSVTTMRGMFSSALAFNQDLSSWNVSSVTNMRDMFRGASSFNGDISSWDVSSVTNMESMFMSLSSFNQDLSSWDVSSVTQMQRMFRGASSFNQDLSAWDVSSVTDMAAMFYEAPLFNGDLSLWDVSSVSNMGSMFSSALSFNGDLSSWNVSSVLRMQYMFSKALAFNGDLSLWDVSSVTNMVSMFYQATSFNQDLSSWNVSKVTRADRIFEGTIALDESIVCQWSDAWKGLFNCIGYPTNAPASNTPIPTISGSASPTNVPISDTTSLPTISGSASPTNVLISDTTSLPTISGSTSPTNVPISDTTPIPTISGSTSPTNVPISDTTSLPTISGSTSSTNVPISDTTSLPTISGSTSSTNVPISDTTPLPTISGSTSPTNVPILDTTPIPTISGSTSPTNVPILDTAASPTPLRPEDSSATNSKSLYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCJ9</accession>
    <name>A0AAD2CCJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RCK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS1132</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1925228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000036">
        <property type="entry name" value="Glutathione-regulated potassium-efflux system protein KefB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46157">
        <property type="entry name" value="K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46157:SF4">
        <property type="entry name" value="K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="175"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="13">
        <location>
            <begin position="571"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="831"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1925228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="861" mass="91198" checksum="F6DDBA78E5853743" modified="2024-05-29" version="1">MNNSPRTSFSTLKARHDVCVDVTARDDDPNEPSWAKRKVQSCRRFASKTKTWMSKVLFWKTKRGRSMLAAAAVALSLLVSSNHQVGESYHNPTAHMNNNAQEINVVRNSPTPDIEIRGGEASKPVLPIKMGQKSKVEKAVSTAAESTSKTFMEAMVELGNYMSGPKSDTMLLLLATALITPICQKAGMSPILGFLASGMLLGPNGWGLISGVHTTETLAELGIVFFLFEMGIELSVDRLLSMKRDVFGLGLSQFLCTALAVAGVGKMVGLPGPALVVLGGGIALSSSAFVLQLLKDKNQLATRFGKAAFGILLFQDLAVVPLLVVTPILAGGGGGLAQALGSAVLKAGIALGTITLAGRYLLNPMFKTVASAKSQEAFLGLILLTVLGMSFMTEGLGLSNTLGAFLAGVLLSETKYRYQVEADIAPFRGVLLGLFFVTVGFEIDVNLILSNLPLVSCVVAGILGIKAIVTTLLSLAFGLSLSVSQQTGLILSQGGEFAFVAFGLARSLGILDKPTTKLMLTCVSLTMALTPAMSSIGAAVAKKLEENSDFTHYLGEDRDANEIKESDDFAVVIGYGAVGKVVCDLLDRKLSKYVAIEVDPNKAIAARNAGLPVFYGDIGRQEVADAFNVGKAKAVIVCISDQAECTRAVIALRRWYPDVKIFARARDKDHAYRLQSTLDVAAMVPILPEDNVLLTLPFGGAVLKALGGSPEEVNAILETKRKEVMSGRMSEDDMALVQLGIERAKKQPVLVKKPSLPGDEQVLEKVISEEEKDEADMKDAIAGRLSEVSAKSPFVAAVIGQASEKKEEEAGPAVATVEAPPLEVVEVEIVDEKANGELSAEATEDASGEKTADSSAASDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCS8</accession>
    <name>A0AAD2CCS8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000095">
        <property type="protein sequence ID" value="CAJ1929834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="568" mass="61056" checksum="3F611B6182F35365" modified="2024-05-29" version="1">MKQPLHSSFSRTITKQGGTGGGSLASSWRRRRSSSPLRITTPSKSKCQLSATGNDDDDDEWWDLEEDMAEIAAMGGDPSFLLPVLDEPKSKNKGNDDTNQERSMPSKAPQEPLSSSSSSSSSRDLEDEIAAMGGDPSFLLPEDIESKDNNNRGGESYNERSIPSKVPPVPPSSWDLEEDMAEIAAMGGDPSFLLPPDEPKPKNSDGGKSTFQESSSISSKVPPPSPSSSWDLEEDMAEIAAMGGDPSFLLPPDEPKSKGKDGGKSKENQESSSIPSKVPPPSPSSSSSSWDLEEDMAEIAAMGGDPSFLLPPDDEPKSKDFVGNVVDEDTSISEFDRSNIGGDSFFSSSSSDNNNNNNNIMERDDRRFEIEAMGGDPFFLTNDIDQKVLQQEEEQEEEEETLPEAFLELATMAGAASPVMDLIDPAASSSEPMPSSDTKAPNKPPVAADTIPFVRNNSRGEMDLDDNDDNDDDMSVAAAEIDAMGGDSFFLTNNGDDEDDDDSNEDTSSTTKNAALDELKQLAMSGGGGVADMLQGGMDQDSSEKNNDDDDKWEWDGIVDEEAHLGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEJ9</accession>
    <name>A0AAD2CEJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000207">
        <property type="protein sequence ID" value="CAJ1932125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="132" mass="14702" checksum="12C392761391A425" modified="2024-05-29" version="1">MEMKNNRVAFEEFGGDIKKLIGYKRITGHMVFDVKLGENFRRKARYCADGHKTEAPAALTYSTVVAQDSVRILLTIAALNGLDVQCAEIQHAFLTAPNLEKCYMIAGPEFGDEEGKRFIVRRALYGLKSGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG50</accession>
    <name>A0AAD2CG50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">galactinol--sucrose galactosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS3549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.82" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000324">
        <property type="protein sequence ID" value="CAJ1933999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041949376" description="galactinol--sucrose galactosyltransferase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1933999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="940" mass="103886" checksum="B934C2AF4594B774" modified="2024-05-29" version="1">MKRLRMQSQHTDTLLCLPVILCLLLSSGITDNHNHHVDAFNVAPTTKRMSNKQKTFRPMVSRSLDDLNTEVDFEDFEKQDDMPFDFQQDHDITVIEKATSPDNKPAIWLDAEGKLSVVNGENGKDNLLLLDGLKPDTWTSVMSEKAQLQEDRSSLFLQVQHTDLQPLHELTLGNLVSCNRMLTCSRLTRYWMGPAFGNHAKDVPVETQFMLVEMEEHGPYALLLPLVDGGFRAALEPSTHNKDELNIMCYSESGEAPASSSAMKALYVAVGNDPFELVQRGMQEVSDTLGTFRTLHQKEIPESVNDFGWCTWDAFYSKVNPEGILEGVSDLKKAGVPPRNVILDDGWQEVSPHPADWDKTDKAAAATTKQPNLFSEVGNAAFSQISHLVGAYYDKCVQHAPHGGISNRVWTILAKTILKKGLWNFFDSETDFNRQLDSFEPNFKFQNDKGKTGSLSLKDLVHELKTDLGLKKVYCWHALHGYWRGVTTTLGDSVGIDVVQVKTKPTKHLKRMEPQMGFDTISLFGVGMMTHEKDLAKFYKHLHAPLVEAGIDGVKVDVQSGVSAAGSGIGQVGVQVGKIYTEAMEHSVSKNFASDANGAVDCINCMCHSTENLYRYKVTAVARASDDFYPLRPESHSVHLVNVAYNSLFLGEICLPDWDMFHSKHESAALHAAARAVGGCPVYVSDMPGQHDVHLLRKLVLPDGSVLRAQLPGRPTRDSLFADVGKDGKSALKIWNANKSGSGIIGAFNAQGVAWNFQRNENEEVDASPAPVVTQVRPHDVETLRTSEGPFAVWNHRSASLEVLDSGDSPIEVTLESRQWDIFTIVPVQSTCRVNWAPIGLGDMLNSGGAILYQSGLEEMTTIAGEEAVRKTTTTSFSARGPGKMVAYCDPCPSNIILGTDSVPSELPFNYNKETKLLEFDLPDEAVNMPEHQVTIAWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHU4</accession>
    <name>A0AAD2CHU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS3257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000258">
        <property type="protein sequence ID" value="CAJ1933318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="588"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1933318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="704" mass="73674" checksum="CF2D22F86D618167" modified="2024-05-29" version="1">MYSTTTTTVVRLKHRRLCDVRSQLQHQSSRTLASWNGDNVRSSSSKATIVTKDNSFRDRFFHSNNNTLQQSKFARFKSTLKPSSFSTSTIVANKDNKEQDDAANVQSQESSYILDFGLPKLIPEWRKMFSTETLFTDISAGLTVGCIAVPLSLAIAVASGVPPEVGLVTAAVSGVAGGLMGGTTLAVTGPAAAISLLVVGAVEQHGMEALPFITLACGGMQLASGVTRLGVVAKLVPVSVIAGFTTGVGTLILTGQIPKALGMATPAGLNPLEVLQFVGEHVSTINPSSAALALGTSAGMFLLPKIHTKIPSALLAVGGATLATHGLGLDVALIGAIPSGLEAFQFGLPLLPAVDSLPSLAATTFLIYSMTSVESLLSCAALEKMKKTSYKYSPDQELVGQGLANMGSALFMGMPVTSVIARSGLNLRLNAATRLPALVQAGFVFGSVVFFSDNIAMIPMPALSGMLITTGMSMLNPAEFKHCYAVQKMDALPFATTVAGMVSMGLAEGIGIGCATAMALSYQQASMAPGSTTMLPPLSSTMMNVTPVPSVHHALLPESALTNEATHVTSFTDANGEKFLLDADKSSVLQLDGPINFVSMFAIDNMVRDLHAQMSSATAEAEAPANDERFVVVDMEKVTNLEFTGMEELATRLIEVADANEGVTIQMVNCNDAVNNAMDQCDPKQEIQRFATLTAAATATTTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJW2</accession>
    <name>A0AAD2CJW2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Interferon-related developmental regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1887790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1887790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="255" mass="28196" checksum="E60B202926658B83" modified="2024-05-29" version="1">MAKKQRQKKGEQSKRKGKVVEIEELSLSHSIITAGSETAGSILSTDSWAGDNDDFDQADDGVTRTSEERERKLQDAFAMVEDYCSEKRSTRRESILRKWYTALTQYTSGSYETVECKLSDITRGCQFSIRSGSPSEQYAACRVLETVAVLLADESFFGQTYQTLLSTTRSTHRAIPVRIAALRAIGMAIFIGVDDDFIVQEVLDLCEALARSEYRGEKVASGLRAAALTVWSVLATTLHEFYISGADDVSTGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMI5</accession>
    <name>A0AAD2CMI5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000391">
        <property type="protein sequence ID" value="CAJ1934814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042229457" description="NAD(P)-binding protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="38924" checksum="C9502388783B4DDE" modified="2024-05-29" version="1">MLLPLLLFRCFINAIALSDRLSPYMSQGRVAVVTGASRGIGRAIAVQLGTENFTVYTLGRSSRKSSSPIPGQRPVAEGLDLTVESAAEEVSRRGGDGHAIVCDLSKDNEIDRILSEIFAAEGRLDILVCSAFAVPLGTSIRGDFWQQDMDMWSTLMNVGLRQVYAACRAAAPSMIETARTTKKAPLICLVSSFGGKSYTFNVAYGVGKCAVDRLASDMAYQLKKHGVASISLYPGLVKTEGNLAMVEDGSWDEASGGLDLSQGESPAFSGKAVVQLTKLNREEILERSGNVEVVAELANEFGFTDIDGSQPPSIRSLRYLLPNFVFPQVEKEAGKPIPQWIKNNVPDLLVPWSVFSSPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMM6</accession>
    <name>A0AAD2CMM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052636">
        <property type="entry name" value="UDP-D-xylose:L-fucose_XylT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032:SF1">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="3">
        <location>
            <begin position="332"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1939293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="618" mass="70405" checksum="2CAF705B633D52BD" modified="2024-05-29" version="1">MEIRKPANKMSYPSSVLLICVGLFGFFSGSLVTMYSGLTSCHEHYDTERLDPMTQCAHVVEPIVQKRMMDMKEKLSKECEASKKREEVQIPVATQRQAKESSISTSQSTFQFPSTMSRYLVGMARTDKMDFVDTLDLGVPVDDPSNNPRTGNKEKDVLLLYQKASALPTDYNNDSRSKQNDSSGLLPEFSTQEALEHCEYVNVILTDHSASRNQCWAMVPQYESYHVQKWMRVRPMQELNPKEPLRLVSRGTKSTGRNDFDPPARKHIDKGMEMLQNYFTNLESSLAELKPLVEKVATPKKTVTIMVVNFGQSELLVNHVCASKSRGLDTSSILVFATDEESKDLASSLGLAVFYDEPNFGAMPKEEARGYGDRKFTAMMMAKIFCVHMVSRLKYNILFQDVDIVWYSNPIDYFESNHMTFDLMFQDDGGHSVRYAPYSANSGFYYVRYNERSEYFFHSLLLSGDLILSTNSHQQALIATLNEHVSLYGLRVKVFSRDSPDFPGGYQFHQVSGKYMRQLFAGEVNPFIFHMSWTLNKDNKLLFLRQLGEWYVQDQCVHKTTSEIMGSGIFGSRSSSKSFLDTCCAAEPLFSCHYRDKPSKEPCKDSPSIDKGKGSWWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN43</accession>
    <name>A0AAD2CN43_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS7047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN43"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="345"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="636"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="860"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1102"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="872"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="916"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1028"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1940448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1139" mass="126689" checksum="EC56008CF8CC8EDD" modified="2024-05-29" version="1">MSSRKGETGRRKGSEKHGYVKTKNGFKFIGGAAAVRAAAVRKGRGNRILKPGEVEKAQQLVSGGLSPFERFFAGLLKGEATDFLNKGGTATWNSICKRLRLPFPEEPLKHYYCDQRQHFLHRASLVMEEARYALAEGLTKVQRLSSDEERFKRSQNNRNRRHQRHGNGSQSNTMLLSLTGVEVREKHGYCTLTFAKDRGTFSPKEIQNLRQGQIFACVSQNLAPTIANSVLGCILASNRDAMIDSNSFSVVVFKAVSKSQESTWRVTPVASLLTEQRKFEACVNNNTHNIPFLLPLLGGKKPTHIKFTEEETGDILAVKVEDEENQQPLYSRTELNQAGFHLPTLNPTQEKAALTFLNSQPNTITLIQGPPGTGKTTLLVNTICQYLMESIAGNKARCLMVCAPTNKAVSVLCTRFLDTFKNINQLPCNVLLIGDDDKLLDDENSRNFRCGGKSPLRSIFLYTWIKTVVDRLSEISQFLARPTAKEALRVTSLSKRLLMQLRQNLSQFPQDLGKAFDRVVELMEDGIEAGHRNQKEAFNTIEAMKSEILDWKQDLIWQDLLSSAHIIFCTLASSGAGILKRSIGEVDDLIVDEAAASCEPEMYIPFHFRPQRLLAVGDPRQLPATVMSNIAADRGLSKSLHERLMYDAGYPHIMLDVQYRMKPAISQFPSKFFYDGKVRDSPSVMSDDCPPDLLLNGENLSFLQVSGTEKQCRFGSFENYAEAQAVVKLVQSASRRMHGQWQSADRIRIITFYTAQVLLIKRCLRQCRLSDVVVATVDSSQGSEADIVIVSLVRSHGSPKHSSVGFLSDDRRMNVAITRAKYQLICVGNAERMAALTSPKAKTIRALAIDAIDRNCLLRSMHTRNSGPNKRQRADTNNEGREKRVRSRESIPDNTTKIPLSDSHRVNSNGLIDEDTSAREDDRKQSSEDQHENESKNEKRASGTRLGNPKTREIPNSSNFRNSNDKRSSSGNAVQLRPCSASTSSSSSNSSSSSSSDSDLSGQNEIPSIVRSSDVCSPSRSLENISTRSEDRYDNDPFERCSQDEFNDPIAQDSNVGDEETAAIQIEHSSKFSVLETRSLTAESGRSEIPLALDTAMVMSDDSASYGDNRSELEWNSDEVGGNNESRTNMDIGNNRDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNG4</accession>
    <name>A0AAD2CNG4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNG4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="425"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="533" mass="60042" checksum="311B7D032EEB2865" modified="2024-05-29" version="1">MQSSTSDTDGEGSASSSCSSMLPLSSNGGDDGRLKHRDELDAWQELVSSDLNALTAQERSEALEDIHCVGGEIQETEEMMDQLLAQFDRLVQQEQTPIYAQIARQNQFYVEDPSFRLRFLRCNSYNVQPSVRQMMAFLEHKVVYFGEDKATRDITLNDLTTEENDLLLSGVFHIQKDGDRSGRLVVHIMTHMLESWRVETLIRAAHYMWNSVILPHPTAQLRGVVAILYHGSADSKKQVLIPDSNLIILLMQALISFPLRYSAMHICLKPRTQHLTSLNGATSDQAMNILPRYIRVRTRLHFGTDASLQDNLRSHGVLSETLPVDSYGNVRDEILNHWFYEHQSSALGSIQLIGDTLSDDSRSNAKMCSMKTSSENESDASDFLHLFDDDNGGMGRDKMASTTKLAAHTNVSTKQKLPVGADANDILLGRGWRVQHHEGNVRFRALLERHCDAYDASPRLKKRQLVGNLVRSIQGKGMRFLKQASSGEWIDSTHEDAAKKVSQLFRTIRKNRQGDPTGRARSDKRTKSRNSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNX4</accession>
    <name>A0AAD2CNX4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000815">
        <property type="protein sequence ID" value="CAJ1939604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005049">
        <property type="entry name" value="STL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362:SF0">
        <property type="entry name" value="EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362">
        <property type="entry name" value="GLYCOSYLTRANSFERASE STELLO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03385">
        <property type="entry name" value="STELLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="221" mass="25711" checksum="11604FA761AEC49B" modified="2024-05-29" version="1">MTFDNSEGATNVLVPKHVYSPYNAQASIHTKPALWATLLPTTVPGRVSDIWRSYFAQCIFADPNLRLVFAPPKIEQIRNDHNILGDFTAENDLYTKSGKLIDFLSSWDSEHLHVPQRVEQLWIDLYERSYIELDGVLALQKWLEALITMGYRYPELKPRFRNVPLMGQFNFADFPNSMTQIMMLIQKMRERFQTTIAAAPLNETQLAYLETSYRRHTKPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP70</accession>
    <name>A0AAD2CP70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS2577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000184">
        <property type="protein sequence ID" value="CAJ1931854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP70"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1931854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="241" mass="26432" checksum="2E38D0A853C17A3F" modified="2024-05-29" version="1">MKQGTTENLMHFKERFLRQAEVLQDLYGVAWFRNFAVKTKAYAAIVSTNTIAKDKFKDDIFEATNYCREVDYYPKTVSKAQDMLKIHMDVIKNPGVNLYQGKDQPNKGKGKGKPKDDKKKAACYVCGKEDHMSSKCPDRLLPESQWKHPKRYVDYGKKLNLNQIGATVPTTATVPGTSPATSVITGGTLSVAGSLSTPLQLAGTTGNQMIQVPTGNQMMQVPSGMQLVQIPTQGGGTVTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPG9</accession>
    <name>A0AAD2CPG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000813">
        <property type="protein sequence ID" value="CAJ1939576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="490" mass="53926" checksum="5BD8EA6B9F2CD0DE" modified="2024-05-29" version="1">MDKEMIKMNQGGNKNGMTETSAKQSPTETLEAWKQVHTQLINAVLVAKEAIAAKKLQRRYWMEEICSNLNPETGKLNSSSVWKQPDVSNKSNSNGRTNKTAATKKRKRSTEPKTKKSAAEKRKKGSKKKPSPAKENALDDNEDDNKEEQVMEKVKKEESAEKSPLSKKKKKKVVKKESHDQNAEAKAQADIPDNKSLCMSIDDADDDDSSPDHSAIKNEDKHGKNIDPREESDEEMTPLEKTKTTGTAHHDSNPRASPSPPMHPHDYGPMGQHNWGATAHHPHHHHQHHDPYMPPGGGFGNPHAPYHHPHHAPHPHHAPHQHHMSPSGMHGPPPYGSYPPYGGPPTHHHHHPHHPHHAPPPHIAAMHHNHHHHASSSSSSYPPQHAYEMGGGGISATIPSPRASPPPASAAAAHLPSKNNNTAADDASSEDDDEEEEEEEEDEDDDHDDEFTNTSPGEKEGKSEKKVPPLAILGGADDDDDDEEEEDGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPL9</accession>
    <name>A0AAD2CPL9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000539">
        <property type="protein sequence ID" value="CAJ1936045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPL9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="204" mass="22827" checksum="14B9DC0936E11894" modified="2024-05-29" version="1">MPDSTKVRTQKASAGSVFDRLYKSSTAASRSRLKTHRAAARAPIKKIAVDEDCSKIFNRLYISGTISNTGKRVTPRHPSTPFKKTVRSPLNRTPAKTPSTKSRDSFVYSPRMKPLTKLTFKSKYHPSLGALDTPPLKLGMSFFQSFCQYETGEKDSKGLAKEIIVAFFKKDSPAGKQWELHDPCARRGAVPTREARSARRKLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPT8</accession>
    <name>A0AAD2CPT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxisomal membrane protein MPV17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF121">
        <property type="entry name" value="OS09G0315000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042169320" description="Peroxisomal membrane protein MPV17" evidence="7">
        <location>
            <begin position="26"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1940066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46633" checksum="FCC9067071A51A99" modified="2024-05-29" version="1">MMMIKSLQHLFLAISSLLLLLSANALVPNDCLSCRGSNTAAAAAATAFRARSPFTSLPSWKQPQTRSLSKHSSLVVLLSATAVDDSLVESKQKTQPPSLPPNDDNDGELDLSSRIINFVFLALAFGYAAYTILNIDNGMTRGWTTGEIAMRIPLDNWGAYEDYLANKPIFTKTLINVIIYLLGDWLSQTAFQGKNVLDFDISRTLRNGFIGLCFGPLVHEYYQFSDTILPPENGFVTRLEKIFMDQTIYLTVKCSIYISAVGLLGGDDLATVKQTVQDKIGGVVVTAWKFWPLVHCITYGLIPARHRILWVNSVDLVWNAILASKAQKTDEDEDGSEEGGEGEASSLVLDAVAVEIENDEQEPAQAHNSLKGAGDEVPSLILENNNKLSLVEEESSSEHNTVAAEVMELNGTMVSGSNSTEKGVLVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ48</accession>
    <name>A0AAD2CQ48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ48"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="2">
        <location>
            <begin position="254"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="682" mass="73746" checksum="4599B51134266126" modified="2024-05-29" version="1">MILVLSRLVQKLPLRPKLTSIPTNSMKIHSLALAGAFVQASAWMPNIASKHNTLLSIVHQKRTTHQSPVQKVQSQLHSTFTPEGIELPTPLVPTGNTIADGTVVSIFRGGFAAIRIKDDIDEAYATPQVVDTTGKLPKSFKMNSLGGDLIGHQVVFNSGQTGVIVTHRPPIVFVYTGDDEIQTMDGSVEILDSLAKVSVPDDLRSVDCFGTSLLGKSSSQKGAAADAETKQRAIFSPIPQVKDIKLINSPLITGVTMFDALAPIGKGQNMLLIGDDVEDMRGYVCDFLSIQAKRTRCVYASTQDNDKALEMLQKFGLQDDVITVSRTSGADSDKISQAAEATMVAATACSIAESFALEKGEDTLVIVDNIDQHKKLWDATTRVLVDVFGIESVVKSDRDGGASSEMRAFFSSLIQRSAAFKVKRGGGSVTLLLLTTIPRLSVDDDSREFTADDFKDSPAKIKDRIQLLTDKKVPLTTATLRKIQIPIPSDSEGMRRLSLQHVDDLISMSDGQIWLDEELKKSGRQPPMDFQRSVTRIGIGADTESRADAAAIRRVVEGLRLDLSQAEHMEGAEMGAKSSVKQVKSAKSWLLAMHQPPLSHSRSLSESIVVLLAASKGHLGDFIDKGYGAGTKEGEDLIANLVSHVKANAVNAMEEIDSTQDLTPESTKEIENAIKGFLSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ53</accession>
    <name>A0AAD2CQ53_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ53"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1942748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="160" mass="18191" checksum="5EB70D2813607C88" modified="2024-05-29" version="1">MRKRHSEFIAKQSRSSIFAVAKRTMPFIYCQDPASFTYLFCTSASLLYLTSCNSREMTDEESSLATVNLSKYIRDEILRSGIAKLVFGEEHRMKEACLKNTLRAMMKSFDADGSDDVNEFETWGDNELLNYNALCPYLVCGRSIASTIAAFLALEHTNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQF2</accession>
    <name>A0AAD2CQF2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000280">
        <property type="protein sequence ID" value="CAJ1933519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="363" mass="40745" checksum="891BCDC002A5EF14" modified="2024-05-29" version="1">MYRTIRKRIQPIASNNNNNNDNHNDTQDDNDDTDVPFDERINQKVVKKEPEMKSESLCRPRSIDLLALRQRQKQKQKQREGVAIARASTYNAESTYSPRRTRAGLISRTAAASNRDQTTPDLVPPETATTTTTTTLKTTVIYTPLPTRSETPKNKPDSTAQDDASNVVQENNDDSSSSSFCSNYTSDDDDYTSSFGSGVSSLSGVFADLQSSNYDDDTTKLLEDASHLQQEGETTLGDNTTQHDSMETDVSDDEDDNCDIHDEEYTSFRRNNNNANCRMMCFVDDASDSVGLEDFLDTDTNRHREKQQRHKSHWKKKQVTLEPEKPKSSLSYVCESLDCLGLWKGLCWGNEDATVGLTAEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSF4</accession>
    <name>A0AAD2CSF4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001324">
        <property type="protein sequence ID" value="CAJ1945048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSF4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="375" mass="43715" checksum="510364EB1D87CE90" modified="2024-05-29" version="1">MKMMLSQKQAILGLLGLAFTMRLPMMLLKQDFWREDFNLSPVTFSNEANITSDDDTAGTNSSIFKSQVLEEQETIAPGLSHYSTKASQESFNMTKVWDSSIMITSNLIPTHPNIDMLKDTIYSFYQFLKDIPLDTPIYVVVDGLPEKKLTDDNRIREKQYIEAVRSGDFSPFTNVIVSPMGVHRNLAGSVKYTLENYIQTEFLYIIQHDLPFSNEVDHWRLLKTMREHPDVLYNVRFRYNNKKNTRDSQCRSYKNMSDFPAKDFNGLDFFSVKAWSDNNHLTTKKYYTFLLSKMKHHRRAMETVLGWKARWNCTYLGQQIYGRRDDGQTHICHLNGRVSQSYNDENKTDMTGWERKAMWCRNQVYGGMNGTNHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTD5</accession>
    <name>A0AAD2CTD5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001358">
        <property type="protein sequence ID" value="CAJ1945331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="171" mass="19393" checksum="7A03E2A7CF2FCA71" modified="2024-05-29" version="1">MTKVGSNIEKFNLYVSEQFENLAHYGEESKDVLIHLFEGYKAASNKSFVSYIGRKEEKHEDNSKPINEARLMQDAKNYYKNCVHDQTWNCPDENQQAILLLKAEFKQIENSKRSESGKKKDNDKKSGGGKHEGTGKNNSKQKSSNVSAWKTTAPKAEDKLKAKYVNGDSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTP4</accession>
    <name>A0AAD2CTP4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000535">
        <property type="protein sequence ID" value="CAJ1935997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTP4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="16987" checksum="9323B18029003CD0" modified="2024-05-29" version="1">MEGTVTRLTYIFLLCVWLVLCRLIWDSGLFFKGNNSNNSKPLNWEDWMNLAPSVMSSLPSASALATELEEVLITESTKQKAVKERSHSDMEAKQLTPEQEEQLKDLIDFTLGDEIEREDLNAEEVQGILNLAIADAQEAYGKLNLRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWU0</accession>
    <name>A0AAD2CWU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VDE lipocalin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWU0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046422">
        <property type="term" value="F:violaxanthin de-epoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010028">
        <property type="term" value="P:xanthophyll cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044682">
        <property type="entry name" value="VDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010788">
        <property type="entry name" value="VDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33970:SF1">
        <property type="entry name" value="VIOLAXANTHIN DE-EPOXIDASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33970">
        <property type="entry name" value="VIOLAXANTHIN DE-EPOXIDASE, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07137">
        <property type="entry name" value="VDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042214484" description="VDE lipocalin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="VDE lipocalin" evidence="2">
        <location>
            <begin position="42"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="338" mass="36957" checksum="E01457E0560ABDE1" modified="2024-05-29" version="1">MLGLVLSSASVFGGSAALAADPAQYDGFAEYAKENKMEQSDVGCFVQKCGDQTKALFSNPRGIKGVTCLGRCKGEQACATRCFAEYGSEDLNNWLSCTIEENECVKVPKNVDNSAENVGYTAVVRKFDPKSLVGTWYKTDGLNPNYDKFDCQTNTFTSSAPDSSELDMGIFFRVQRPEEAGGGFWENSLTEHMVVDSLLSDASPAERTMHTEGKMYGLQFDENWYIIGESDGKGEVPPFVLVAYKGHTLQGNYEGSFVYSKEPKLPEAAIPAVREAANKAGLNWDDYFRIDNTCPVGEPLNDSKAGTGTSTTDWIDLVVGEGGVIDWISPGWRGEYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CY34</accession>
    <name>A0AAD2CY34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CY34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="77"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="315" mass="35466" checksum="80D0DAA549B1363E" modified="2024-05-29" version="1">MEGLQSARNEDIDSGYQCGEEGGSIPQHQTPSSNIGSDKGQQQQGGKKRDHKSSSRELDSVRNQGAAKGTTELRDDDIAFGRGHFSQNHEGNIRMRKIVEKYKIQYQNLRRPLKRELLQIVYREITENGARFLRRNEENKWEVAGKSNALKKVNQTLQSKKRVDSPSLFLSEPTSRVMPRSIVAPHSLESSLRPRSNLMSMPQHPTIPRNLLLGAQDLGQGIGHGMFLCDPAGFVPQPYALSSQIDYHLLQQERNRQQQLRLHCAISLLQQTRAATNAVSCQLASQRVPTRQADKQPITRSDTQGGKEQTTKKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D144</accession>
    <name>A0AAD2D144_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001591">
        <property type="protein sequence ID" value="CAJ1946111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D144"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042163002" description="VWFD domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="60789" checksum="2C22BA391E5339B5" modified="2024-05-29" version="1">MKVFNILSVLAALATVVNALPTETCAQQSECISFDIKKMDSDACGIGGDCVVEICMFVSGTSGNCIKGGTDTFSHMCMQSDASGCPAWKEDGAPALGEGDSTTCTASGEGYGTVTFDGKCSGNDVLMCQEGKPGDTLYWILKDGGSTIEEDVTYDLPYTVAGETEDCSNTVRCFNGEYNCGENDNKAQQARERTWSFTIPEGDGSSCDVCAPGTPPGDEPPTDETPTDTPPTGTPPTDEPPTDEPPTGTPPTDEPPTDTPPTGTPPTGSPPTDEPPISTPPLTPEDPEEPAVAAPTSENESTPTPGSNGDPHFKTWNGEHFEFHGQCDLVLAKDADFAEGLGLDIQIRTKLVRYWSYIKRAAIRIGEDILEIEGSVDEQNPVYWINFEHQREDAKTIGGFPLNIIASTGRFRKHHFEIDLSSKYPGVKIAVSTMKEFIKVDFVGATEEAFGNVVGILGEFKTGKTLGRDQATEVHDFNQLGNEWQVQPMDHMLFHDVSDPQFPKRCVLPEDPQGQRRRRLEESSVTVEDAEKACSTLADELSRKDCVYDIIATQDMDMVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDP3</accession>
    <name>A0AAD2FDP3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS2051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDP3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF15">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="70"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="70"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1930715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="536" mass="58932" checksum="912B9EFBEA3846B8" modified="2024-05-29" version="1">MSDDSLGIKTELEDINEDEVKYDSDGPGRGASPGRPPSSAASVGSVGSGASSGSGSRGRRRTWKKPKDKPKRPLSAYNIFFKHERSRIVEGREDNPSPAEIVRSIEQILSTSRETRRHRRTHGKISFGDLARKIAEKWKVVDKESKAVFEHYAEIDTRRYRKELQLWKDRKEQQALSGSMHEKFNTSISSLDGEVNDDNELSLDQLGPSNHSYGGHSSFGEAWGARYSMNSSFSSIDSTEISLEPLPINDMSRGPIGRSQHSTNTGSLSGSGSGASFPGLGMEVGVPVVQAGGGNTPIGGNTTVPTTAFSQLNVGGNMSNGMQNMQNGMQNMQAMQNLQNLQNMQNMQNSMQNMQPNEIALFNQQQQLLNNMQFGNMQNTMGQMGQLGQMGMGQQQMGQFGQTGQQPMGQVAQQMGQQQQQQQQQQQQQQQNMNALDFQQQQRSLQEQRQQLLLLQQQQQILQQQLIQQQNSLRMQQASLGQQQQGNFGQQQQQSMGMGQANGAQGQNNNMGGGGGGGGDMTDTLNTNHLDLSNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDR8</accession>
    <name>A0AAD2FDR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="32594" checksum="7218AABD95C9D2D3" modified="2024-05-29" version="1">MEPPTTTPKFNQSKKNKPRKKATHCSTTHCPSNTVAMPIAEQIDDERKISMKMICPYCDVVFIIAVLISIAALVMSLLQAIYGVLAVMVFIITLANCFFHSKTKRLGMILAGILEFSMGGICVLRLLHIEDQCDPDTIRYLPCSMLTLAITAGLWMLSGLLILYFVYSGRVGEYIKEGLDIEAVATPLGCVEEPLDQPPHDLEQGDHARGDPDGSENDGDEDQGNNRDRSTELAPASATICIIPDDDSNEMSAERKEKLEQSVPITPARPLESSERSTVSYLPNGIRERNDDEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDV6</accession>
    <name>A0AAD2FDV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000147">
        <property type="protein sequence ID" value="CAJ1931451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="491" mass="55059" checksum="39A618E180B9491E" modified="2024-05-29" version="1">MFSTRLRRRLLVPTTLPSLAMIVALMILVQHSSEAFFCASPILPLKTRLAESTWRTLDTARTKCSQRLYATPKLARTIPVLGPIPGSPPLLVGEDYVLEFPSPLQWNTLEECLHIHELYLKEQPEEVVGIDAAPLVAVMDDVTSQQTLDTRNSKYATIAAIVGVVTPSKVTLDTSSEESFMESLQLITANQKDTFLPSKSKIRLVGIGRASLCGFHSRLPNSYWQAFDKIQGIQGDDEGLDDGEYLDERETPLLIAQFNLMVDTDQRSEGAQKVGRARFVSPVHALAEMSQWTAKLQFMHEDRQRLVRGLKAADARLKASTGTTLEDHDGIGLLSSGFVLDDAENMRAAQPDIDTLLEDFPGQQHKAFSGQSALSQVMQWKNYGMGFTAAAFSSIPPLTHNMMEKLQAYYSPQKQVTEEYYYEVLSFMAVLSLKDFLPRDALNYALKATNTMERMQWAYEMMIEHKLLLKDASEEISAELRDCGEECTDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEI1</accession>
    <name>A0AAD2FEI1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS2991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042246647" description="Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="3">
        <location>
            <begin position="148"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1932746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="300" mass="33370" checksum="AEB5AC2EDE4E1EE2" modified="2024-05-29" version="1">MRSNNIMQYFARAIFCCILCWKASDIGVLGFKQFQRSSMVTTTTTSSSNNNNINANSIGGFHGQNSRNHLQKKDTTVVFQQHHDYRGGAAAADDDDDDNAMPLASTENHHGILFHCAIILNASSKWLLASANLYGVIRYRDPGAFLCTGCIVACFVAEHVLKPLWNQARPLGAKLADPGMPSSHSLGSFFVAIGWAHLLRDLEGNMEDPLLLFLGISSLVASLRIICGYHTVAQVVVGALLGLFLGHGWIDWIWNRLNVKTFLYTHATVRWIIWSAYISGSLLFICKIMSKWIDRQMLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF40</accession>
    <name>A0AAD2FF40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase kappa</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS329</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1901491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000004">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="14">
        <location>
            <begin position="129"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="297"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="699"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="786"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="704"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1901491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="810" mass="90285" checksum="2BF520C07BCAACB1" modified="2024-05-29" version="1">MKSLPSPTKAMPKSHSLQKLKLTATKTTTNKNLPSLSQDASALIISASDKAGMDGIDRSKIDAIILRESGNSLYIQQQKRRDAKVNERIAELQTKKQELLLTRSRLPSNPALDAQMQSWQASCPCRATKVVVDMDMFYMACELLTKPHLDQHPACVGKGMVLTSNYKARQFGVRSAMAGFVADKLVEELSHGTQRLIHVPSNFALYQEKAKEVVAVLKEYDPHLKSYSLDEAYLDLGPYLALHLQHYSCKKENENENEEIDGWKKSDAGDLGNGVLSALPDELHHWIRDQLTGSAVKAGGAANDSDMDIKKDKDAQQKEGEEEASSRAMDDEMQQENDMEELNEADSSGDQDLDGDPKDMNVKDTKRPHQYQNYMKMLKKYSVETCNRAIQSIVHHMRALVQIRTGGLTCSAGIAPHSGLAKMASDINKPNGQLLVDPHKVLEFLHPLPVRKVPGIGRVTQKILQHVFQVETVEDLYEQRALVQKLFKNASANYLLKACVGHIGTSSSTSSDGGSFKSFGANSEEIEEDDHQKGISRERTFRPEANYQKLQEKLDSIADMLSNDMVRKKVKAHTITVKVKLNTFDVWSRAKSLDRNVYIQDADELKVVANELFASIKAELAVKQAKSMKKKGEVHDDINYNTSGIGKSSSSSSKDASFVLCCRLLGIRCYSLEHQDALPQQKPMDKFLTRTDMASAFSSVKQGHIQDDPEGNDEREATQMPRNDKHNGKSGDAPSPENPMKVTQESYTCPLCNSVIVGDNDVLNRHIDTCLNASTVRQVVREVTQSTQEETMTTDPKKKASQKQKLTDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF94</accession>
    <name>A0AAD2FF94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1903911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="253"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1903911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="638" mass="71008" checksum="264F67457CDA9B9B" modified="2024-05-29" version="1">MARGKFNKRGGGKRVDAQSAQEIEQRNQRLEEFEEARAKRRAEAEEEDAEEEGGDDATEEAGNTSKPKSGGGGGPPKAPVQETSAADHKRNLAKLEAVRKRRAVAEQKRLEQEAMEKQIEEERMQKAQAFADENDSDDEEEDAKKKKKKNKKADIPKLSKIEIKKMKPAVMKEALKLRGLEIQGNAKEQAAHAWEDIGGKNTWETAVQEDAEGRIIVSGGASRADMIRRRRKRQEQNDYAQRNRRVVRDMIRYIYVLIDASRWTRDKDPVLPGGTRIEVVLQLLQEFISEYYDQNPLSHLGFVLLKDGEAEILTQLSSSSKTNKLALQSVAEITAREGPKGGGEMSLQNGLEVAGRSLGHQPRHGSREILILCGALASTDPGHLLTETLPRLKAANIRVSALALAAEMHVCRKVAEETGGSLGVCLDKDHLRDWLFGQCVPPPSLKKKHQQFACEMIQMGFPARSTLDIPTLVHATQDIKLLARTAYTCPRCYAKVSELPMDCVVCGLKLVLAPHLARTFHHLFPVKPFQEVLPDENTEVMIGDRVVSSNASIEKWDQTKPKVTTQLDSSLRLSKDGDKTTCFSCLRLVGVPRPTNNPDKVGEPVLRYECPDCTNMFCEDCSAFLHETLHNCPGCLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFZ2</accession>
    <name>A0AAD2FFZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS1055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053025">
        <property type="entry name" value="Mito_ATP_Synthase-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="67"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1923858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="476" mass="53798" checksum="ACA0B1FCA4364792" modified="2024-05-29" version="1">MSSRVARYQLLLAVSSLLVSACFGFVGKELTLRTRNAHLPLRYASPINNGDNQGSYSALKEEAKSKTLYEILGAPATATREELKKCYVKKAKLSHPDAQIANAGSNNTITDKLDFNEIAQAWNILGDDKLRRRYDRELRAQAFSESAQRFANENLERAVPAMANMVDNFAAPFLRRTTATTWAVGQAVAKEVSSHENVELSDTWKKAVQAGQEVGRFMDGVDLKEKSKDLQSQAQDQLKRGTEIEDELDALTERRLLATLQSKDFFLSSDEATDVLNRLSIESENPTLLGRAMMRNTIEQEIRLLQVAEAKFSEKLKEYEATDKEWNTLLNKQDEAKMNLSKHKMEEMEARRALERAQRQVSEAKSQLLTSTNALRGIEQSVRKNAFEMDRMTSTLSQKQEKVRASLKKKVDQARGGMEVEYLTEDDLTALRRREIQLVGEQNQTRRKATQLQTEAESLKKQADNAEPVNGQQGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGF8</accession>
    <name>A0AAD2FGF8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGF8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="165" mass="19165" checksum="EE37AA4794501ED9" modified="2024-05-29" version="1">MPILPTIATPFGSELSLSDLFAIDDTRRKRIDANSSKDSHDTIETTSCSKWSFSFLEAEVLTPKSILKKATNSSGSIDTNEDEHLQSWIEQPIPGCIESSIGSSNRQRQYRRRISGQSSNKYYACMKRRFLGRQTRRSRQEPRVRQIRTEKTVEEQWVRTCRFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHA9</accession>
    <name>A0AAD2FHA9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000713">
        <property type="protein sequence ID" value="CAJ1938403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHA9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="217" mass="24542" checksum="138936A73A2857CF" modified="2024-05-29" version="1">MGYGFECLSALESQLVTGQCFCFVNNTDVIEAGNTVHHSGEAICASVQDAATLCAWENPSYWRRDQPQEVLLMVRPNLLHKYNLLPLIKFAIMKKLEYPMALTTLDAQQWTEILSTVLQVCLPKAGVCRNFRWAVVFAPLSYQGLGLPHPFGCQVFKHLKISLRHMANRTKTGDYMEANFQAHQLETGTSFGILQQVYNKTAILAFDMWMKSSVSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJN6</accession>
    <name>A0AAD2FJN6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001125">
        <property type="protein sequence ID" value="CAJ1943749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="222" mass="24881" checksum="4EC0B8A17BB00198" modified="2024-05-29" version="1">MPGFEPDGGSEEDTAAMEEEKNETEKKKGSFGMLREATLLADFHQTCPSKLPPQVSQEGLRNYIHSRLNDNLDPSFQTEDDGESVNFEYDDDHEEEESAELSIESEARNNPNGSFVMDLDVGSQYGANYLPNDITLPTINFEVDDPHAPQPPLHNIPNPDSSNYLLDRLSTTGNSCHHLSAPKWKLTFTSFVSQGWAHKGTKKEPNLFLSDPTTRSELFTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKU0</accession>
    <name>A0AAD2FKU0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001580">
        <property type="protein sequence ID" value="CAJ1946090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKU0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="201" mass="22576" checksum="E1E50C0262F3127F" modified="2024-05-29" version="1">MLMLVDAKEKMDALGGYGSESSSSANEKKASNQKSSLIGLLGSPLSGTDDDDQQVEAPRNPQKRQKLQGVGRNETFARSIPSPRTTSAYGTSIAQLDEDYLSPMLKLLHYDETSKANMSCFRLSMAQKLRSANESMSCQTLAQNVRSQSDYHNPRFLEIVRDRFRIERSLQSRAKHVSSDLKQYEKQLFQIGHVDGLEQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLC4</accession>
    <name>A0AAD2FLC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="16"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="20883" checksum="89D714905E24A609" modified="2024-05-29" version="1">MSNIAGLNDPPTVLPIDSKEDGKLIDLSTLMEKNECFCRNEDPSFPYTNLFIGDSILGCKSDADEQMILHIAFRETVRVKSIKFKAFNEGNNPELNPTVIKMYVNRNNLGFEDIEDVDPTQVIELTAKDLEATSDPINTKFVKFQRVGSITFFIEENNGGEVSALGGLHIIGKGLASMNVNELKKQPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLS8</accession>
    <name>A0AAD2FLS8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS8080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042103960" description="N-acetylgalactosaminide beta-1,3-galactosyltransferase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1942704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="48159" checksum="D7B13C14C8EA0F87" modified="2024-05-29" version="1">MQGRNFLCVGIALYVSSHFLLQQSFNGGSPLDNNNADFWSWSTLDVPITKTVGQPSKEDEASSTSLVDTTRQHPHAGARFPNGSYGYIADVTMVRQQMLKSLEQNSNQEHTIDVMSYLPLNSEELETVCNSEPREPSLERKAGWRLLRRMKVNETTLPSINLPPGSKLLCAIYTYEKKHKAVKAIGETWGWRCDGFFAASTTTVTDPTEPGLGAIDLPHKGKEEYENMWQKVRSIWAYAYDNYIEDFDYFYLAGDDTHVIVENLRAYLESLGPRAKSEPLYLGHWIPDISGQTGDYFCGGGAGYLLNKKALRMLVKDIFPRCRPKLQTHAEDRTIGECFRKFGILGNRSVDAFGSQLFHGSDPHFISHYKGDKGYYQQVYDFWGKHFGHKTGLAYHLLRGPMKMKRHHAIIYKSCPQGTLLGDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLU8</accession>
    <name>A0AAD2FLU8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLU8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="588" mass="65431" checksum="F3444C8F5FC853F1" modified="2024-05-29" version="1">MDPDEDPGMDPGKPSKEKKKSRKSKSESRKSSSRKSKKKSSSSKESEDYSDEGQWDPVKFDEQTGDCWKDIDKPKRVADLPSPDIADYERQEGDEDWPYKKSYAVDERKSKSKKEKGLTAPSRAKSDDEGEVVGKEKRSSKKDKKSKSKSKSSRSSSSRDHDDDAAAAEVSDEEEDLHSEEEDEARARRRPKKHSSRKSDSERSSGEGHDDDVSDGYDEGSNNNADSDEFSEDASFYSDEDEPYSSDLDGSIDSDGTYDSAEEYGDYGGMPPETPAMMNYNQEINDLMHKANPEHTDHLMNRVNRQKGNIAYDQNMPMMTRQALMTRQASAQAARARVDANSVDRSRLGFRNESFHGKSGGGAKPVRRGPGGKRAPPRSKSSGLGTMAMAGRRAAPSAGGEDAGGADDPRSRFRGRGASTSFQRHSNKPNNVARMSGRRGEMDRSGHRPAAGSSASRGEPRRGNVGRAKSTTALSRGAPSAPQKPLRRQPRRTTKEEQMKTNEVSDESSEEYDSDEESDSDEGQRSRPKRRVKKVVDKQDMTIKKHRRKLHGMMYNIKMSVEMSDLMKEVKKGEIPKSPIKTLLMDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM58</accession>
    <name>A0AAD2FM58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001269">
        <property type="protein sequence ID" value="CAJ1944890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="438"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="617" mass="68561" checksum="5513697BF85CD037" modified="2024-05-29" version="1">MPIKKNKDEYDAQGVRFGLCHKSHHHDRKRNRVNGQTKPRATRTAKDTTGNCLCNCPLSLKFSRNKEFIYLACKGEKIHKYHPKAPGPLPLKANNLTDEQKQQLLAQQRAAVANPQSRKILLELKQGYISKSAYRTVMITAPDYIAAKAVAGANSSAAEFIGWLRAQAANPETNLSYMVLSYALTSKNCCVVRRYIQNPKGWRSNSNPPSNPETVMNNLTYRDELLLPIEIQEPLASSRKSTPTPPIGKGGLVAKNNLCQAAIDRVALPMWQDYCASVGVEDHLQNTKAIREKKEAIFCRAANEVDNQTIRNSLAYTSGDGKESCDEDTACSHMDCNAAQGKVGIADKLCAKPAPIVPKGLYSIANVSIANQTNDNFAQSVEVESTLKGVAPMVELVEQAETHLLASSDTIMSPTKVMLGGAWMTEAEKRHFFRFPEVLFIDATHKSNNKGRPLLLVCGRDSGGKAFAILQMFMPNETKAFYWWVFLEVLPAMLGVAHLKRVNLILTDGDANEYNALDQGIFHYFKNAIRGRCGHHLIEKTIKSHGPSDGELENQCNGRAIILEVKQWVRSWVDGSSCGTKEQFEFSKQLLLSWRRSCTKIGSNKFPDCITQKTTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMG0</accession>
    <name>A0AAD2FMG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(2Fe-2S) ferredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02980">
        <property type="entry name" value="TRX_Fd_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13025" checksum="0D099E88FAB9321E" modified="2024-05-29" version="1">MRSQILCLFILGNVYSFTFNNFSLIRPSELYAEHFEGRVVVCTGPTCRRGGGKKNLEMFNELAPEGVTIESINCVSDCAECGMGPNVELRAQGDDGPFYPIKNGVKTEEDVKKILGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMG5</accession>
    <name>A0AAD2FMG5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001482">
        <property type="protein sequence ID" value="CAJ1945746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="82" mass="9249" checksum="2A05E0D483764DE4" modified="2024-05-29" version="1" fragment="single">MAAVPPFFTIHDNMVICGIDKVTLFQGRTQAKRIAYKIFSDDFSTIMDSTIDELNQEFKTLAGLTIAQGQIRLMPAIKKNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMR0</accession>
    <name>A0AAD2FMR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001680">
        <property type="protein sequence ID" value="CAJ1946467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="3">
        <location>
            <begin position="648"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1262" mass="140315" checksum="FC2D5FC2529735F6" modified="2024-05-29" version="1" fragment="single">MTNAVSIFALDSDSEEDDNLHHNIGLNKQKSRAKGLPPSGQNTAAKLVGRRVWAKVAVSHSNGFCSIRNCKHDSLHPNHACIQCKCGVHNLCVQENMLMSISKEDGHWYCSKECGGSDVLATHDVGVRQVATPTSTPTTTTTPRSTEGAKIQEENLLAAEFEDCVVDLACPPQAEISISSLEELEESSEELEELFEDSDDMDDFELEEGLEELDESHDIDESELEGSGDMMSGSKDMLSSAMASSRVMPVASAQEESKHQLYPTLPAENSDFFEEFSDELQIVMDHKSQQRYKSAVSELSCDSSFGSSQADAFDELSMGGRDPSIRHISFAHEARSSQHSMETENQLSNNDERSFSKSPNPRRRKVGSQLSNSERSYLSPRRPRSSLALMEERNSGGGAKPGDPLSSSERISYNKSVYPRRIRRGATRRSSATSERSAKSSDFTDPLSSSERSSLSPNQPTSVLRSVSLPVMVDPLDNSERVCAMAKRQVDANDDGDQLSNSERFSRSPRSIRKPRRKRSTRSPRRTCDDDLYSIGSAGSCDLDNDYDDALSRSDHTSSFRDDGSTGHFSRRSRGRGNKVDDALSVSEKMMSTSPYAGKVRSVMDGLTINKLQYDKVGLVGREKETKRLMECYARLTNTTTNITDTYMQSGQKELVFVHGYSGVGKTSLVSSMLEVCDQSATGFCARGKFDFSSGDLPYAAFASAFGQILGDIERRGSLSVSTYDESGKLQTLGEALTAKLGTDVNLLATLIPKLKVMVQGSVPRKSSSRRLDVNGGFEANQSRWVYALRVLTRELNKIYSPLVLFLDDVHYADQSSLNLIDSLVSDVENENSFMVVGCYRSNAIGENHILPKKLDRLSRKTTHYGFNLSDIKIGNLDQEGVHSITMSLLSMDNKEKTEALADICFKRTHGNPFFLIEFMTMLTEEYLIQFSLGSFTWFWDEEEVERETMSTENVVNIVHSRVKKLSNRAQQVLEYAACLGSTIRVHCLAILVSNLKSDQGGDDLDDLLHQLEKGGFIEQIEPTQYRWVHDNVRKSALMLGDAADRFFQFDVGNTLYNCLDDDELDEVLFEVCDLVNMGQHARRVEYAKLNLRAAEKARSISAFQSASLYVTKGIAYLPNDKWTAQHDLTLQLCILGMEMELATGQVEEMEKYSEEILAQPDCTAIEKLPVYLAKSHRMTHMDIDHKGCTDLLQRILSEKFGIRLFKSKAVLPIQAIAKLVSVARTVKKLPRGALANLQPVDDSNLEAAMDLLVRLAISSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPT4</accession>
    <name>A0AAD2FPT4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001753">
        <property type="protein sequence ID" value="CAJ1948739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPT4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="721" mass="80016" checksum="29635D307452BE8E" modified="2024-05-29" version="1">MSRPAKYRQIQTRSAESDGDNEEQDFNSDHDATLSDGGPNRNPRGPTPDTEPEDTAPEDTEAEAEESAEEEEREVPLSAWVHLTHEHCWAVCKGPTSNSKKDRIICGKLKTKCRLHRVLREEGHRAKPMWHEGIVSTKDKNTNTGDYIIHGQQDGFSRSEERMDESLNRATGLDNEESPSEDEEGPEDTDREETDFEATDFEASEGEIEGHLNEDPKADALQELNDKIALMERETQLLRLKAERAKLEAESPKKKPARKGKQATPSKKKAQATARKQTPIARKKKLRKNKPPPKQVSIKEGNNTSKSPSKPTAATARKLDPELSAITTTVPSVLDTVLLKIQPFFIKLQESTEKMDRMMEQQALQENQTPSTTGTPNMIPMGSTNLPTANGHYNAMTIEGNGPAPPTLPTQTPPAVITPTRPTTYQGPIPTYQQDGSKGDSDKIHEIEITSVEIDKAMMPEAMTKNKEINGTYDRADDIAALPGKTSPGGGDSESGSGVSEDVLTRLAETLGSDNSKITMLDSRYGRRNRHGLGLITSEDTLLDAYKQCYKKEDVIFNNCPDRQDHVHSANLLDIRTNCNSKKMLLLQNYAYLCDAKKKGFVNDTITEKNFERQDRRNQRLRDELEAVKAIKGGPKEGRGNPHKDQDSSPKKCSHCKNRDLHIAAGLEHIKTVCPLKDKAGSWAKAAAGKVAAKYANNNKGEKTRPMEEVIKEVSESWAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRV6</accession>
    <name>A0AAD2FRV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053019">
        <property type="entry name" value="GATA_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353:SF23">
        <property type="entry name" value="PROTEIN HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353">
        <property type="entry name" value="RAB-GAP/TBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="595" mass="68725" checksum="BD767166A233097F" modified="2024-05-29" version="1">MNIVPSSSSLFWRNKNPLKRRRRRRRLKTKVYVILLVGTCLIILHIYEHWQWSEFRNVYWTEELLVYDGGGYNRSGTSSPSSASNNKNNNNLRAGGGTNNENHNKSPKMNDNNRNDNPNAKWNPEIIFTHRDVHLSEQADATATTKSATFMEDTKNKASFVRDSRQSIQFSDFVNKPNDNDNDNNDNTKQQDVSSSSLTYEQAKEGREPLLEILEHDLGLAKLTTTELLQLPKWSEIQDLYGSKPMLVGTDTCLKYQTKVPLQDRYIGVAGSFNSGTTAFGLSLQQNCRFPNRRHSRHNRRHNRDTQTAGEGNNKNPAGNIVTNVHGMLNQVPWAKHKMARERFGHTIDESIPKENVLPVVLVRDPYYWMQSMCKQGYGVRWDHNAKKHCPNLVPNEYDQKRFKRYASLNQTSVPVWMGQSYESGPHWDSLVHYWNDWYGSYYYNNNNSNNDNDNHQTANNNHQEDFPRLMIRFEDTLFHAKTVMKLVCACGGGIFSGNEDEEEDDGGEINIGFTNDNTAKQQQQQQHQMGSAFRPIVDEAKFEHKHVQNNLVSAIVKYGTEKGRYRNMTQDDLEFAQTHLDSELMKAFHYKQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTN6</accession>
    <name>A0AAD2FTN6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="108" mass="12445" checksum="7F7B7010ADA6F7FC" modified="2024-05-29" version="1">MKSSCGNNVSTSKMGCTAPQHSNPLANTKNGVFVEDTKEISCTLFESNYATSLKRRKDFDENSRRRELILDDAESLNQRMGEYRRQKKTGRYIHIFDTDSDDEEDLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU64</accession>
    <name>A0AAD2FU64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF252">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="102"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26242" checksum="CAC2D4BBA1F120D4" modified="2024-05-29" version="1">MTSSTSNEPVSKKPKLTPTSIKVYYWNMAFWRADALRAALYLQGIPFDNVTDKTEMDELKAQKKVPFGAFPVMEIDGKILSQTQACATFVGKLGDMYPSNDDPFAQANCDEIINGCTDVTDTVSSTFRAEDKKSAREKLMDPKDGRLYMHLNGLNSVVCKDGSEFACGKDSELTVADLCVWRLYNWFYNGTIDHIPIDWIGTSFPNLKTIYDNVESNEKIQAFKKEYYPDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU65</accession>
    <name>A0AAD2FU65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU65"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1953431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="119" mass="13748" checksum="68B9FD2C708E7A62" modified="2024-05-29" version="1">MLSRVSNGFRMWMPNMPMIMTSATNATAKEPARAIFRVLPRMTKHEIKEYLTKIYGLPVQKVNTMNYMGKRKIVRGSTKVLYFKYRDYKKAVVTFDKSFTDVGLGMSIPEIDDEPADEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUN7</accession>
    <name>A0AAD2FUN7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUN7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="193" mass="21879" checksum="B2B3D28D551F278E" modified="2024-05-29" version="1">MPSPTEQTLESRLLDLESKLGFGLPTVTKSDIAQRLDKVQTAVNQQTTAAFRETWNESQALFKELDPGMALTHQQQPLLYRRQEVLASAATLDKDMQELSKIMHLLQPHTEKGKGLREDQVTQAPILTSYQITPSDEQRLDQVRLTMDDLSRRLQQVIVRTDAMLESYHTIMAVASEKVVMADETIKAKERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV58</accession>
    <name>A0AAD2FV58_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001855">
        <property type="protein sequence ID" value="CAJ1954071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1023" mass="117879" checksum="EAC528A952FCDE00" modified="2024-05-29" version="1">MLDTAAVQRYLRLVHQGYDVYSIPSRLEQLHRQLTLNSGIMTEKMERQYNCLHKQMYNIRRKAEARCQRVTNGAVPWSPQIQNFWDRQSLWKLLLKGRKQCRVSSRKIRRLMKKTKLPDAWKKTTVELETALRNDRKEYLHAKKNHAVSWRKEFLTVQVKKSKKKQWTSRKARDRFLRLRRMKQREEARRRRRAQSKGSTGGLQAIQVEEQLPTGQVDLRTLTDRRQVEQGCMQENRTRYDQTRSPYTTPPMDKPLYSMFMGADAEMNSHALLEGRLPLPDEIDSYTQSFLEQCRFHQGHSMIPMEVSPADHTYFWSCNPENKGSEPHGLHNGHFKAGIYSPMVAQCDALFRHIPLTTGFVPDNWRHLMNFAIEKKPGDLRLTKMRTIQLMNSESQANYKKLGRLAMAYGEEHHLLADGQCGSRKHHQAINLALSKRLVWDLLILQRRSADWISNDATSCFDRVVHWVAVLAMMRLAIAWNALRMMFDTLAMSTHQVRTGFGDSEESFQPHTWLKRVWKELEDLDIYVALDTPVLPLRCEGDALLIEVFMELEVDQDALKWLNWCRMFLQFCTVSDIMTADGCSIRESMWHGERDYAHRSSYQWPCTVRPNRNHWKVWQEHLTRALLVSDGPQRLLRHPLGPWIDPLDNWSWLWSSTHGLFHRQGHGWQHYRHRRSSTRSIQWDYPRSTQLSGCKGPHNEHTDNGVSFLPAPFWTQPLPADLCRATVHITSSLGTLALTGIGTAPLQPHHNSQPSLLAASARVTEYVGWTPEEIEIDGYESLLAAAILEDRLCAISDGSYKLGLGTAAVQLLPHKGGTERIIVRCQTPGLTDDQSAYRIAPQQAQFDLVSFIREALARSRALWEPSHVFGHLDKATSFLCLSWWSKRNVEVDAWAVAYCHQLKASHRLIAPNARFFTELAALYTGDVKQSRLNPEQVQELVALPALRKRLHERQTSLDHKACRGYVWCREVQSPVGCRRLSCMSLRRRVGGPPSRSLMYGALSECGMGALDGVVGPMVGHPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVH2</accession>
    <name>A0AAD2FVH2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001849">
        <property type="protein sequence ID" value="CAJ1954029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVH2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1161" mass="128473" checksum="AE11282A9C049DCC" modified="2024-05-29" version="1">MKDSITNPPEKDPNSIMTVADQGQGGLEGKNRSNSTTQSSIALTKDNPAITTSQRRSKRYPSKTAEDGAMKGRSLFPSDVAQGQDGSMAKARSNSTTPSSTDFTEDNPDTMLSKSQRKQTPPSKTAEDGAVQGRPLVAYTKKLRVSKFHRLYKKAWRQEVFGNQAFITWSSRTAEHFGHAISKCPGWWAEASTDQADAHSYDEIAALILSGLKVYDPSLGGSMPQLRSSMQNLFSLGDLEDADNDKASWSLREYFLRLATQCPTVVFDLAAAQRVIKTDEKLPRFWEFALVFDPTLIVQRAEPLTWMWLAASEFFAHPWTGPAILPPIVEEFERLERESKISKAQSKSKKRPASTPENPKGAKANDSRPSPAVPMQTDPALKGRFQPFQRTPPSDATPPRQQVILSDAVHVIASTPGTQEASAPTDAVVEASKPCVRTSEEHGAEDHNSAPTYRDAAASLPASTVPLTTDERLTRLLAVTWNASPFRHITIFNVSIVFDWQGVGSSEFNQVQTAYNAFHQFASGIWGEITSTVVLLPFADGRFTRQQLWIRNLKEFDEKAKDWAHLKIYLDPNFGNPYILNKPGKTGSKTYKTRMRFGMDTAPPILMQELRSVLSSEPRAGVFPTPIQVSDMVRLGFLPLLPQELAIGPYCKDLMRLCDFQYPIGLMQEWVNNPRFFSAKFTGSSRGLLCWHVFVPKSFAREADLILAANLDIRKPSCAPFQAPTHYTRDWQAAKDELVLGKQCPQLQSVIEAMRERTRATRVLTATYRIPIELPGMLTSAVTENFGKLTLLRFLIAVIVTGAQAKKAEDAEPKKPPAKAIEVLSDSESSGDDDDDDGPPTFEWTTIIKKSLVASTPKPVEETKTSLLTAPKSPEDDDAWIDKLAQMNLTNNSPSPLFVMILPAKEDGCYFVVVRQRYLPLAMNVLDNLPSFLQFHLGKSSFPNFIRVIKNWSATDLAYQNRKLHIEWVPSELRSRCIDDPTNEQGPQVRDPMDFLLCTEDPVEILEGTLHIDIHAKHVWDVDDGLSVIGYLKDWNENQAQLQTALQTIETITDERNSLNRDLQSVCDELEAMKAAHEAAAAMSALATDVRPVPMLIVDVPTGPPGQTRISTTTLLSPSARTIASPATAQETDGEDGEDQPNASSPMDTGRGGISTPTTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVW1</accession>
    <name>A0AAD2FVW1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVW1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF22">
        <property type="entry name" value="OS07G0227800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042185760" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="196"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="548" mass="60800" checksum="FD7A899C094ADC78" modified="2024-05-29" version="1">MMPRIMFLSLVLLPYAVAFLSNPNGQMLSPVKTTTMNPKISHLEMSSRATTSSSSSSSRRKKSVTDRSQEEAVALIQDIIQAAVDAGPRAGPARTFQAYRAFADTFKEFLPTPPLPGMSREVPTFSVPKVLRTLFEKLGATYIKLGQFIASSPTLFPKEYVLEFQKCLDKTDPLEWSIIKRVIEKELGPISKSFDYVDTKPLASASIAQVHTARLKTGEEVVIKVQKPGIDASLKADLGFIYVAARVLEFLQPDWERTSLAAIAGDIRSSMLEELDFEKEARNTEEFRRFLAENKLLNKATAPMVYRDYTTKKVFTMERLNGISMLDEETISKASNDPTMGQEAIVTALNIWTESVMKMPWFHADVHAGNLLLLDDNRVGFIDFGIVGRVSDKTFQAINELSTALALADYKGMAEALCNMGATDEEVDTEKFGKDIETVMRRIANVQTDVTVAEMSDGSVSGAINFDETEITNLLLELVDVTEDNGLKLPREFGLLVKQSLYFDRYLKILAPELDVMSDSRVTGLGDSAKMIEGKGNNEDSKDVVIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXW3</accession>
    <name>A0AAD2FXW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXW3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="461" mass="51433" checksum="3CB037851F666181" modified="2024-05-29" version="1">MKSPVNKQVKPSSPSYTTSTISPNNKGTPYVYKKGGPVPPAIAARAKQVAESRSKTTTSIPIADGQLELPQVALSELKLGKLLGHGSYSSAYEIKEGKGISFINKQRNRIKMKHNSHKNNASSPTNSSHGSPTNGTNNNHQNHKKQILKQLSPKVKENPLLFAACAADLIQEGQILHLIGTAQPNIIDIYAWSGPNMISDYLQGNPDNCSLVLELLVKTLDKKFESWQLASTSMWYYVYEETTQPEYLKILAEKCRYILGMARALEHLHQHRVLHRDLKPANIGFNQEGVLKVFDFDLARVLPPPPTDGGDDLFQMTNNVGSPRYMAPEIKLKDQKYNCSADVYSFGILVYQLLTLEVPISTTVRDWSTENKYIPTEWSKELRHVMGDCLKGADHLLERPTMAKIVEELDKCPTVKQPKRTTPTKAAPKTELAETTNTNSNSNPTHAKPIGPEPEKKGWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYM0</accession>
    <name>A0AAD2FYM0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="445" mass="51007" checksum="B12C7B5976363B44" modified="2024-05-29" version="1">MADTSDRDSDDSSGDALDVSPETESVIVSLVDDEYIAKQITEFRQVLLDKAEEESEFYLEERLLSLRLGAEFSSDLVSNSNEEEALPPEIERRILVRLVEAYYIGQGDVVALGRQLTSFHKALQPFWKETNPGSSTFSRLPGETSADIFEHLRSVFSSEDAKNPSIFFRAFCYAHHRLDYSSLVDDTLLDAYCLCFFTIQVLQGSFHGIDLDIGSIHTMIDDEFFDGKSHDDIELTSEDILWCFCHLLLRIGSVIRSKHGLDFYNGIFAEPYSVIMKEELLVARLSMDLRPESPASFYAAYRMVMDTRRILPEKMQSGWLEPAYGFAIQGLSKAEKWNDPFFLYIFIVIRAFWLPTSMEAPDSYSFGEIRAKIETANEYKREAKEYIPSHQFWFAEQHEVLLRNILKAFPIDDDFEITFPLMDCTTFRPIQPKGKKTTDTPPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G014</accession>
    <name>A0AAD2G014_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001942">
        <property type="protein sequence ID" value="CAJ1957405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G014"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="298" mass="33936" checksum="FCBC9B1A5BB918AB" modified="2024-05-29" version="1">MDAKQQQIGKELKVVNAQQRTGNKLKTGGQSIAEDGNVDTAVERDTAVVWEQANGTLLDDDARQQQSCEKPPIASDKDGVTIPKKGVDGAMEQKQSVDDDDRSNDTSISNLNSDTKDNSSLMLLDDKVSKIWIDCSQDKESIPLPIQQDDMKQSPDFNQSQSTVSISWNQSTLPTLAEVLKRSVQQPEQNFGLEAMCFLRNIADRWFQLPPSAVLDNHISSWKLQKNARACFGYLFTLVQQKDLENRIKTMHEDMVDLRKKWQTTAQEYHREAMFFDIKVEKTFVQKSWDQLECIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G021</accession>
    <name>A0AAD2G021_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G021"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042270064" description="Nudix hydrolase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27259" checksum="7F6120D386F13E23" modified="2024-05-29" version="1">MRILSSPILFIIVSFLANCVIQAFCTIPPSLPASKKCGESIQTKNTLQLRGGSEDGDEESSSSFEILDEKIAYSGWRTIVQRKVKMRNGKVVDFDLVGVKTGDAAVLVFAFDTKTKTATLIREYMPASHKVLWGVGAGLIEEKHGHDAYLAAQHELEEECHLTGGEWIPLTNAATAMDKYALTNIHAYLVLNPEPAINPKPLDDEEDIEIVPGVAIGEIMEYIANGEMNLVGGWGCMLAISKLRELNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0Z9</accession>
    <name>A0AAD2G0Z9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001996">
        <property type="protein sequence ID" value="CAJ1959440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0Z9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="417" mass="48121" checksum="04AFB76AB66C099B" modified="2024-05-29" version="1">MDEELTVMMKITGLLVDMMIQLEPRYRDYVVIENGERVIYVRVLRAIYGMLQASMLWYKKLRGDMEKHGFIFNSYDGCIANKIVNGKQQTIRFHVDDLLSSHINPKVNDDFCEWMNKKYGSIKPVKSKRGKIHEYLGMTLDFSKRGKVKIRMDDYVNRMLNEFPVKFKENEGCKTPASNDILSIGKGEKLDDEKRETFHTFIAKGLFLSKRARLDIAPTISVLSTRVQKPNQTDWKKLVKLMHYLNGTKGMHLTLSAKDLRTFKWYIDASFAVHPDFRSHTGGVLTMGERGLQIISKKQKLNSRSSTEAELIGVDDAATQILWTKLFVEAQGYPVKENILYQDNKSSILLEKDGHDSAGKQSRALNIGYFFMTDQVKKENVTIEYCPTEKMWGDFMSKPLQGQNFLEFRSLIQGEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1U1</accession>
    <name>A0AAD2G1U1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1U1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042017932" evidence="3">
        <location>
            <begin position="24"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="488" mass="53315" checksum="00DC76536FF83582" modified="2024-05-29" version="1">MMVSRIQLLLLLVMAVVAVIVSAEEEHSSQIHEARTTTTKDRTKRRIRGRRLALPLDTELDDDWDYAIRAPKDDPHIHSSGKAGKAGKSGKNDSIQIETQSPSKTQNEEDDDGFDNGDSSSKPPNKGNSDGDSTKLPKGDDDDVSLDDDLASLHSMPSESPSARPSQAPAGLGPPSPQLVGMIPGGPSPNQSTIYPKDPQAPIPTDTESSVSNNATDGPTSTTNAGMMIGVAVSGVGLAAVAMFLFKRQKKRKRLVLTASQLEDDDMEHERGGKRRKIVKDGVVNDDDDDYERGQMEALVSNPTSSSRTSRQAPATPGPLSPTKVRDGVIEDDDEEGWSFTGVYKLQEHYNLTGFLEATGVPWAIRSAAARARPIHYITHEGNVITMKFKGVPRATYILDGPAVENVLRDRRFACKAIPIYTVDGYGFEVHQQGVDGGDYDIQLRWTLSEDDMTVQLTMTAIFKPDPKKNKTREPVRCTQIYSRIGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1W3</accession>
    <name>A0AAD2G1W3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002017">
        <property type="protein sequence ID" value="CAJ1959758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1W3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="668"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="737" mass="79630" checksum="7716562D69E9A3AF" modified="2024-05-29" version="1" fragment="single">MENTTGPSVISPTNKPVNGKFAYWSDNDGSESVESAPDFLAPSHSDHPPTEVVDGNSPAPAQRANDPSATVLVDSHLSKTEPPNPPRPSAPLSVKQQLTYVAASQKKAAIWTKYLSEEMKAREVTQMNLTGLPCSNAQFLCATINYEWDGDTSEGGSIEKCFTEKMVLVLSMAMDNAEGDLVILPVSELRVWDKKLWLTSKEKVEEPTYKKLKPYIDWSWNNGARFGYNAKNPGSKTLHTRICVAYNSSLDDMSQLLGQCFEITGTHAGIFCSPLQVSDPVQIGWLLNYPMGIGRLALEPELMHRFTFKRGIALEPAWPQNPGTAGQKLMPSKGPKAWHIWVAASDVDRVARALFAWLRPETKKCHMPFGARTQFVYDWGAITKGHLGDLAQPGGQWNGIIGKLINTHDTTSQTCTSLAPLFPIQGMLTKVFIPKYCKQGKGKSLLQFLYAIQCIPAVKKPAPAMPEQSATQDADTPDSPLPPSVSSTPPKLTLTNPSVTASTTAQPTLPASSTKRSSRKGSKNRRAKQPLEKPTETPQATTLTPLPWPTPALKSPPQAATNPPTASSAQAKLSASEQPLVTEAFDCSAWLAAMDAELNQGPAEYERDVNLDQQVEKDDNEWIEKLLAAEQASPEFEGTITIGLSMPATKDMDDGATVGSAANMAALLENMKADVNDLCTELETAAEKLAQAKDVEAAKDACILELEAKMAAQALVTGKHRSSSPSSSKATSSADSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G211</accession>
    <name>A0AAD2G211_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS17762</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G211"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046466">
        <property type="entry name" value="Borealin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10512">
        <property type="entry name" value="Borealin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="10">
        <location>
            <begin position="37"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Borealin C-terminal" evidence="11">
        <location>
            <begin position="113"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1959340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25606" checksum="B6AF5345A9E8B023" modified="2024-05-29" version="1">MSSTLYQRSYLPNSGRQVLGNVNENDSSSFDGSKIDQVNALLEDLDGKFDNICSVLKAELNQHKCQQEEILSTELVKLPRSIKQMTVKDFNESHGCDLLAILKSKDGVIPSSNTNLIPMKRAFNSVMSTPSIRPSNPALQGSVLRTVRKGEGIYSQNGSPLESFEKGSVIATVSKKRRGNESESASFEISVGDGKFISLTDPSGVQGLDSNMKATAATQLKVLQDQMASLMAQLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G262</accession>
    <name>A0AAD2G262_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dickkopf N-terminal cysteine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS16816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G262"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039706">
        <property type="term" value="F:co-receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039863">
        <property type="entry name" value="DKK1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113:SF6">
        <property type="entry name" value="DICKKOPF N-TERMINAL CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113">
        <property type="entry name" value="DICKKOPF3-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042190948" description="Dickkopf N-terminal cysteine-rich domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1957650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38213" checksum="15673EB09025E9CA" modified="2024-05-29" version="1">MKLFLVAPFLAALIGIANAESVGTIRGSARNGGDNRARSHDHRARSRTEEPRSHDHGRNSGEPRGQQDEMIRTSPHAKERNDDMPRSYDHGQEERGGDGSLCFSDSACDPGTWCVRGFCQECRKIDSTEDCPSGEFCSGPFYNCKPLLNEGQLCLSDNACESGDCDRGMCASGDITSPTPVESVSGDGEDGSLCLSDNACGPGTWCVRGFCQECRKIDSTEDCPSGEFCSGPFYNCKTKLDKGGLCLSDNACKSGDCDSGMCAAGDIQPVASPTPVKPVSGDGDDGSTCLSDSECENYCVAGFCQECEAHSHCGSGDEFCTGWPTYNCKDKKNNGSWCGTDMECLSGDCGITWAGVKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2B7</accession>
    <name>A0AAD2G2B7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002053">
        <property type="protein sequence ID" value="CAJ1960214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2B7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="347" mass="38959" checksum="590DF956802FCAB2" modified="2024-05-29" version="1" fragment="single">TTLSELTTADGCSLTAASLAGQPSGHFVTSYNWPRARRPGPSHWDLWRRVLSQAVLRPYSRGRRLLQPLGPWSDSLDRWTWLLSCTSSILFHRTASYLFIYRPINSRSHRTFRRDLHHNWTGPLPGDVQRASVDLHPRTAYVTVTVTAPVDPPDPETLPSSILHIWRDLAADMADKCPEYIYIEGDKQVLLEALEKGKLWVISDGSFKQQVGTAAVQLRTRHGGHVVWIKCRTPGKREDQSAYRSELIGLLAGILVASWLRLRLQSLAKPQVHVACDGITALRQAFSTWPLSPTVPHFDLLSSIRAALRVSNISWAEQHVGGHADRTKTWSGRLHGWPMASSSFVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2C9</accession>
    <name>A0AAD2G2C9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS18416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2C9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1959999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="572" mass="64851" checksum="1E665106F59939CF" modified="2024-05-29" version="1">MAKFPKRLFELLKLTEDKGWEDIFSWVNDGTGFKVHDREKFEKVLLQKHFNTKRYASFARQLHAYGFDCVRTGRNTGIYSHPRFKRDDPKGSAELKRETGRNISKAAVSRRNQECLGKRLGDRFGGTRNFVLAGDTIVLVPSLLDTSNESDDSYQHSSSVMSNLYNTIRSQVADRTKKALIRIPSEATIPGADLPFQSRNTGFWSGTTTSEGALMNDSSGMHDANNTFWSPSTNHQRKVSDADAALSTNITGGTTTMNGRSLMHTVSESEPNDVFASRNFIHDDHDNDLNPIPLNTSLEDHNLFHGVDWDPIPLSPEGSVSDEDEFGLPNQVDSFMEPRPINEMVQDPATMNNWLYDSVPMLGTPRKRAMLEFSLPISLPIGFYFLDVSTYGIYWVAFLILGHFVECLFTSWGGAEDEKDKTYTKDLSIKPTIGMLQHHIMDLLWFHSLLSNMMLTPRKFGSPCFLLLYLFIWPQPFNLCMAIKTHYCESNLEGTYSHGKWWIGDIVKNVFIGYALAIVGVIFMHFYDMTFLRIPLVFGFNMIPLFAFESYRYLLSTPAILSSGVSDAKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G301</accession>
    <name>A0AAD2G301_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein Abitram</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G301"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039169">
        <property type="entry name" value="Abitram"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651:SF0">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22814" checksum="2B294377A08AB770" modified="2024-05-29" version="1">MVKKSKKRSFGEITKREYASIQFEEREPINHPRSPHSFFETSHNIKFSDCRNSFEMQQVVHKHRNDLCIVTAGGKIPPNVKSIHFVACEAPAFSAAQKRKRQTKMLQGQKLEDAVSPSTTLVELELESGEKIALKACVFGTIIELNKNLTPEVLKDDPLLDGFLAIILPSGSFPPHENQDQAATESSHEARSKTKDNATTEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G355</accession>
    <name>A0AAD2G355_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G355"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000043">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="249" mass="27826" checksum="B0ACD1E1AFCEF05A" modified="2024-05-29" version="1">MESLATSGTPLHAPYTFSFMRRGRSLKPEEGMPTAAQPTEQTPNPYENSIKTISIITTVEEFWSTYNFLRRPNDLPTTTDYHFFREGIKPTWEDSNNAKGGKWIIRLPKGLASRYWEEVILALIGGQFVGVPDGEICGIVVSIRYSEDILGIWNKTSTDTIIVERLRDAIKKVLQLPTFANMEYKPHQNSIQDKSSFRNTHVWKSKSGGGGGGGSAPPPPGPDARRSGSWGEDNRKPRRGGGESDRAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3V1</accession>
    <name>A0AAD2G3V1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS19405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3V1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="105"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1961853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="325" mass="37314" checksum="965A828557985B14" modified="2024-05-29" version="1">MLQQTNTLHVAIRAASDLTATFSASVFGTQPPSSLTCGEPGSNQVQFFLDPFEDKECAGADFILVFMMSVVIFVLTWWGRWFIWEPLADLRISGSKKHFDPSVKKRFGVTLTSIIVHVCSAFFVFRILVPTEWLYKPSCWVDNIDDDTIDADLKFYYLLYLARYCSDSVSILFEERRKDQFLQMVYHHAVTIGLVVCSINARYTRFGGVIMFFFDWADIPLQCAKASKYLSVEPKDFYNYVANRLFELFAITYFLTRNCMFNFVVYTALRDLPDTSSGATARILLVMLAAIQTFWLTLLIKAVKKQIANGGNVEDIREEDKKKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4L2</accession>
    <name>A0AAD2G4L2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING finger and CHY zinc finger domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS19721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002108">
        <property type="protein sequence ID" value="CAJ1962509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4L2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF53">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="90"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="162"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1962509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40003" checksum="8633A0678D139576" modified="2024-05-29" version="1">MADEDEHMQDDVDIEESDEDPDEDGDEGMMDDAPMQQPEPVEEDGAIARRRAIQAIMRDQSTSDQDKRLQIQALMSGGRTEVAPPPSPVLPENNASCVHYERNCNIVAPCCIRVYGCRICHDELSPAGHAAMNRFLVSQVVCKLCNTTQQTSNQCINCKTIFGEYHCSTCNLWMSQSKKPFHCAKCGFCRVGGADAFRHCDECCMCISIGVYADHQCFKDKYKNNCPVCREDMFSSRQSPQDLPCGHAIHAHCFRKLAGFDYRCPICKKTVVSPQSMAAAWDARARDIAEHPMPADLQRIVDIMCNDCETKSHGLNWHFLGIQCPNCNSFNTVVEQVLSSGADGNTNGANQNQNLGNGSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5A8</accession>
    <name>A0AAD2G5A8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Plant heme peroxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS18443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1960027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5A8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042267197" description="Plant heme peroxidase family profile domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="11">
        <location>
            <begin position="437"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="669"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1960027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="718" mass="76431" checksum="3C36D97868DD1FEF" modified="2024-05-29" version="1">MRINLSSVALLALTGAIPGSQAGCPYMMSKESGPHQTHRASCPMSGAFVDQEQAHQLHNRRLAHDERVGDWGEPDEGYAVVKQDIADALTDSKDYWPADFGNYAGLMIRLAWHCAGSYRKSDGRGGCDGGRIRFSPELTWPDNGNLNFALQLLDPIKEKYGSKLSWGDLIILAGNVAIESTGGPILGFCGGRIDDPNGDNSLILGPNEMQEELTPCATIDQIGTCAYPLGPTVIGNIYVEPDGAHNFKGDAAESQKDVAEVFSRMGFNDTETVALVGGGHAWGKSHGPCMSPPCGEEGADLGIGINAFTSGFDGKWTVRPTEWTNDYFVNLFDEGLNWTLKEGPSGKLQFFPENGPDIMMLVTDMALAEGDYRAISELYRDDIAALEHDFKHAWYHLTSADMGPASRCYGSEVPPAQDFQYPLPDVPVGYGSIDFIPVRASIQDVIDADAVNIGHLANLAYRSANTFRATDYRGGANGARIRFSPEMDWEVNAGTADALALLEPVKAAYPDVSYADLIVLAGQAAIEAAGGSSMTFCAGRVDAIDGSGSKNLDPRTYAPSEVIGIRDNNNVRGLTPEEGVALFAMPGADGVLSNAFFTNLKAGEGTFTAEEEALLDPEFSSIVDMFVEDNAKFLEMFESAWNHLMIADRFDGPLTNACAGVATPTLAGDPTTAPVAPADPTAAPGDASPTASPEESGSFIVASSTALISSLVSAILLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5Z8</accession>
    <name>A0AAD2G5Z8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5Z8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="260" mass="27975" checksum="0D3E807B78D9C4EF" modified="2024-05-29" version="1">MMPGEGETSSSSRSSIGSIPLSISGSFHSLLSAVTIDDESSAGEGSLDNFSPLAMNRDWRFGSKPNLTSMKSRDSLGKFAANNLKERTTPSRMPSTMGLPMPTRKASSNQIMGLNMPTRKASLYNMKSKDNLRNATFENLNSSPALSNAKFDLITGVEPSSAESKKSLFPQVRKQAPGVKLYSTRTTGTSPSSTSTCNPAFGLPNDIFVVHSSPGTTVSKPSISPETMNGFRSIFRHCREKSIDHGVPSVPERKKSSCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6U9</accession>
    <name>A0AAD2G6U9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6U9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="465"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="549"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1964987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="71239" checksum="3DD16F89EEAB0D0B" modified="2024-05-29" version="1">MTSTPSLDPNVQAILDEINKQHPSSSTTTTTQKELRAETKQFLHTAQEYLECRKQMDAKYAEIDPDSTIANLDIQTDSGGIISDQTGTDNQMAYKKEYQQQSLNGAPVTKLTELYDAATAAQQVYQEVVQQLVDKVTESCAHVAGVSEGKIGADTAGAKLQFAPLKGRERAQEKADDDYSDRVPGPGTSWLYDVVRGSVKFSTAEQIAKCLELIQADPTMHIVKAKNRFKNPTLTGYRDFNLCIRIDTQRGFHHVCEIQIHLGPIKQLSIDLSSHKHYEYFRSYFDGSTDSLAARLEDLQQIVQEHTETVIRTRSIDSNGVLDEGILQRLLDKGQNEDRIDRLADLFREYLCEYDWSLRAYAKLLNIRLRKHNGPNDAAVASTFKEMAQVLQHQRRLEDSISFFQQSLDIQKRVLGEDHLEVANTLSSMAAVLRFQGKIDEAMDVLQQGLTLKKQALGEEHISVANTYNTIGGVYFNKRELDKAMKYFQRSLEIYMNVIGEDHKFIANTFNNIALVLVDQAEYDKAMQQYKGCLDIQKRTLGEEHAVISTTYSNIGDVYVHKKDPDTALKYYEMSIEIKQKTLGEDHPSVANIYRNMVKALKQKGDMTQAMDLEAKAYRIEKAAKKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7C5</accession>
    <name>A0AAD2G7C5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7C5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="366" mass="40148" checksum="67A00BABF86E7E89" modified="2024-05-29" version="1">MEEETPTLRSIAIGGPTALPPLSRSFALPGKLPSRPLHHHEQAAAAAPQQPISVQHWTVDSMLPAISADYMLERTNVYVNNSSAQQVADRIVECLSRQSLSYKESDENKNSLLGERHCGLRFYLNLFLDSQDSSTIILEVQRLTGCSFAFQQVCREVCRAAKGLSSSAPAMPRKFPMPSGLPRASSGEIAMRFEEEVARALDMISSPMVDSQLLGMELLEGVSKSPLAAPFILKENSLGMLKELVVSPAEDDDQVLSALVTKRALRKKRQALSIIANCLAHSELTATTDSLHSEIFVEKVFQCLKQIEDPHCATQAARCLHSLAASRQSTKSFILGTLELSQVLDNLQTSHHLLLKQECAKLQSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7H8</accession>
    <name>A0AAD2G7H8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7H8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="502" mass="56889" checksum="81C2E78792B09C13" modified="2024-05-29" version="1">MGSKRSKSTPLTVEESLSGEYQEQFGVQQPSMRSYDDRDHGARSYDQDAIGAHRGGASRGGGSYQSFQQGDYSYSGSYLDGDQPPEEQYYQDQYLSEHGSQCYTDDGEPYYGEDQGQFEQHEQYYGGKNGYNDQKQSPPYEAGYHQGHPDGYPHQYDDERYPEEYDGYQHGHPEAYDEYQIGHPDDYNPEYREAKSQDYRGHRQADHYDEYDDGYDRGHGQQRRDWPQPEEEFSHFDDQEQSYVSYGQNNKRYSSYEARQNAEGHWEEASEIDGGGTISSKTLNTNLEGMKYIPPYDNNTYYGGEESAFDYSEGPELARSEPPEIPFHGASTLESPLHDDEGSQGSGSVWDGTDLRNRSLVDNPVSPLSQTQFTIGNRTEYSDESRSTRRPVSRFIQKTKKNVGCAGVTYGDGEFQVRAKRGKRGGGGSRSKSKRGESATILDIMFNVGHDLIVGTSKDRGGRRRKRDPAGKIVDGFKEMFNCGVDNDVDDDDDDDYGSYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G930</accession>
    <name>A0AAD2G930_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002183">
        <property type="protein sequence ID" value="CAJ1964428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G930"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="200" mass="22642" checksum="3E0404B19C2D5A38" modified="2024-05-29" version="1">MGKYTSLKVVSTAAKKAGGSKSKLGSTSKKSGKKQLENAFSVDLRQPKDRDPKISNDSGTQEVIDTVRPLIDFGLSTQDLVAVGYDKNSTQIKFGNHVFTKWIDDHNARWSQALPRFDSPFQDFYAKFSVEVRVNMIFDEYNNDWQRVLGFLISIFEDDDKNTEYIWGVRAIALQVAQQIPFSFFDIGLLGDLTIQQDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9C0</accession>
    <name>A0AAD2G9C0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9C0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="264" mass="30419" checksum="11937012AE3E933E" modified="2024-05-29" version="1">MFDCPEGTTTLAKEESIFSVLNWGVLASLLSPTTTIVEAAHHHIMDRLLKVASWERQGKISFHLVCNRVENMSQFIASKKPRTMSWSNVPDYMEYEDFHSLARACSVHDNTRHFGYSMNWVMDVFGVNILDYSGPKGAIARGRIIDGSNQKFEKLFKSRGWEKYLRLPIPNNPINISSSVLRLGQCKMWARHFFKTGQHQGYCQVLETKYDFGTPLSPAGAYTLHFDWTYDPPVKKEDPLDTCFFILLPWGTQYLMMQKSNETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9R3</accession>
    <name>A0AAD2G9R3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS21950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9R3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="156"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="214" mass="24034" checksum="89ECAF8F9B4B4A72" modified="2024-05-29" version="1">MVIDAGVSALMAGPLVVIVCCAGGLRTYFHWMNRRLRSEVDGIESGAEQPRIRPHRTRRDRPTSIDLDKIDTSENGQDIIRARQTRTERMMGHFLFGVCVKVDGHMVMANSEDGSKDIEATVAVHAVYESSPQEKLPADEYVSTKKDDSTCGDECCAICLEPYAIGDDLCSGKTEKCSHVFHEHCLIEWIRRHNRCPLCRSNLMPEGELRKEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCG5</accession>
    <name>A0AAD2GCG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S49 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047272">
        <property type="entry name" value="S49_SppA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42987">
        <property type="entry name" value="PEPTIDASE S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42987:SF4">
        <property type="entry name" value="PROTEASE SOHB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041939009" description="Peptidase S49 domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S49" evidence="7">
        <location>
            <begin position="557"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1967132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="767" mass="85729" checksum="80F4ACF44BB4DC3E" modified="2024-05-29" version="1">MKASSRKVSSFSSSLMIVTATIICLGLSGSGSGRGSSSIPTVHAGHPWVSSTTATRKSKPTSTTTAKRRFLATDEDPIAVIPTSSKTRKHTRIKQEDEDAAETKPPKRRSFFFQSRKTDDETKTTEELEPKDKPQNKRKTAPWKETRKPNVDEPTKKRQPLFRFSNRPSKNSKEEKKEADGKSTENNDPKKDKDEEKARRKSRFQRAREARQERRQQQQQQQEKEATHKTTPSNATDTTEESATTNNSTSTDEATNDESKTTSTTSASNNSTSASNTNTTITLFDGVPPRNMPPTRYPPPSMYYHRPYPSRQSGGITLDGSGGPSSMPSNTAILATAIISIVGVASRLWLVLFITNKLASDAEDLLPPIQHFVWECLNDKYSKDARIFDKALRQAPMGFTKWQWKAYLKQEKQKHRRLRKQEKQAALLQLEQARDEMDSNSNTSTTQEERSNSNAAALAMGSLDENPMMSILRRQSPDFPTQTTIVVDLTPKNEPLNLSYLSDIVNLLIQVHSSKNHNKNLDRRIAPMQTEVVLLLTSPGGAVTTYGLAAAQVARLEKAGIRTTVCVDHVAASGGYMIASQTSQILAAPFAMVGSIGVIQEGFNINKLMEKYGVKPLVLKAGEHKNQLSTFGPVSDKDMKDETKRIEEVHESFIELCTSNRPSLDPAICDGSVLLANRALESGLVDRILTSDEYLWERICAGDHVLKLHRSRTDQRRVFARALDLLPHLKQRIQGMHLQKMVTYLVQGYAFFSMARNQLFPILLQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCH0</accession>
    <name>A0AAD2GCH0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1969544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="966" mass="108199" checksum="C498FA8C18E639CB" modified="2024-05-29" version="1">MFQSSRIALALSLVKRAQRRVLIGKLCSSFLCDEFSATQSHQFRGNRKRHVSSMKKNIGNDARNIRNTKVKSVQQALHTVGELIKSLDSSDGHQIEDQKRCHDGVERVLGDIVSQVDEGSLNPLGKHGKELSRFFEFILYAYSQVDIPEISSFDKSGQVLDTLKKWNLDIRSRHYEFAIISANREGRYKEATDLFLRQIDPEAGYNPINVSLDTPHGLVAIALWAQQEGLPAAEHVFDAVMKLTMVSPSDSKQYTLAAGTALGQAGEWESAINYLYDSDDIKQFGQPIVSAVMRACLMCNRPDVALEAFDHCMNDLGIIGGGEWQWGGGRDRIDPLCRDIAMRAMKGKNGTSETALNFFQEVLDEDVTISIEALQGIAEACERDRDWETALGLLLYILEHHSRPNWIVDGSKQEIQERYSVETKLSPDEPSWITKLGPVLASVMRTCNADSNFGTSIFCLLLIDNALGNAAASTEERSLSVKMTAYLSKSEFNNDLVVAAMTSLCGLRLYKTAIDIFETAERDTRMQGSTDARVTSDAALSVYQYALLENSKHGTIETGNPSIHAIFEIERLIEDSKSSEKQGAGDSQQQWKSTCSNLAEAMKACTYIRQSNLSFVLFNWVAMQMKGAKQEFSSLQKIAKPVDLDDAFAMQSDPLLAEVVSTRRWNTNTADSNNVFESLLRNDVSEVGDWANSCNAGVSALLVKGDGDAAIKVFHALDNKAMNPDLFVIIADHLAKEQQWAAVMDLYKAALQEGCYSEELSAIAMKAVVSSEVESRIIVLREMIQNVAQYNGTNSEKWLRERYWEIKGLIGFKYARLLMWWNDPSTCHLDELNFAIEEVNERTANGADVRYETIRTIINSAKRGLIEDNLEKYRWIPSSAEEWKELMQLVIYQAQLTNHLDSRLIDELVRSYIALDCREECIHFVMDSLHSGTRVNKFSLHQALEAAHLESSDAVNDLQMMLSTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGE1</accession>
    <name>A0AAD2JGE1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001732">
        <property type="protein sequence ID" value="CAJ1947559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="304" mass="33557" checksum="2670D85FDEFECC93" modified="2024-05-29" version="1">MDAEAAKDARILELEAKMAEQASVTGKHRSSSPSSSKATSSADSGGAAPPPRRQVAHSLLDAYLNYLPPGNYFGNDSRQKSPCVTRVLFQNVQGLPFPVTHEIQKGLFKCWTDERVGIALLAEVNLQWSVVPRGHKWFDRVKSFTNQGHFSSVSYYEHQEFPTPSAHQWGGCSATLLHKVARRAKSGGKDESGLGRFSWIKIRGRDIRQQESQTDGPLAGPLDLVVVSAYRPNKEGTNAGSVWNYQRNHWLSKGVTMDTRDKLTLDLVDLIEQWKAEGCEILLGLDMSPTTLPLPSAKRCGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGI7</accession>
    <name>A0AAD2JGI7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor MYC/MYB N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS10798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGI7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025610">
        <property type="entry name" value="MYC/MYB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213:SF3">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14215">
        <property type="entry name" value="bHLH-MYC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor MYC/MYB N-terminal" evidence="4">
        <location>
            <begin position="441"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1946708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="752" mass="83159" checksum="527BE0036AA1B41A" modified="2024-05-29" version="1">MAEMKDPAACRTCGYWGADIRINRCGCHIHSRCLPRNFVINGITKENGDGQGCPCCNTAVTGLYLKPLSFHDLEDSVRLRKADVLKKSKSKVYNDDDADVEARYLVFSQGRNTVSSTLSDTDNARTGRWTEGEVAFVDHLVQAFDKGVLPLPQGVKLSTFLGDVLLCKASRLTKKMKNARLSTRSFEVKQTQVSVPTKEDYEVFGALQDRFISSMPTKVAQLELKFNLIKQWRAYFSNLCIETGFKGLDANDWISSVDEFECMASKTEEQMRIVRRKRMGLGGCSTGQHRPLKQARSEPMLQEIASKPMPTSSSMSAFGMELTVKSSSPGPPIHQRAHCEDLDSAILSLYDQDENNFSSPFDEDDVALPVPQALPSSDDPFLAEISRFMEDRKLPFQHADVWVPSFAHGSGEEVQLLHAGHATRRDQGGILFDTLKTFGEFSKTFTFRPNQGLPGRAYTTGKAQWDSHLSNPAFFARSKGAEAYGLRTAIGIPISTPGVGRIVVVFYSSSKLEEDESLVSRCTSELVSYVPTPKWKLVIEMGNPRPKELNQEGHPAITEVCTGTSEHTGKSVVVDQMISLLGNELASASNSDRPPQQDMSLQMMGMRILLLKRPSNRSEKEKELVEILEGSYNAYAKDNTRSQSELARLLVSEYMCLNKTMDPGNSEFSGSEPPMEALHVQHQESATMPSRVYSSTQLEVPGAILPPLGRRNVRTKNVRSDANIRRTVSVSGIGPGGAPVPDPVFNDQAPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGZ6</accession>
    <name>A0AAD2JGZ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="127" mass="15214" checksum="757E2D7BE871D4A4" modified="2024-05-29" version="1">MGRNWKRNQKNKYNRGGKKPKPADPSKYGEHKDPYKLISGGNYKLEAYYAYQDIHQQVFDSQSNDFLECRSDEQKEEERVKWLESMKSILPASFRIGRDVDVVLRDRLKKELEFRRFPLIFTFSIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHB5</accession>
    <name>A0AAD2JHB5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHB5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="642" mass="70732" checksum="9934016C4E6A3D63" modified="2024-05-29" version="1">MVNETEPAETAASNGSNSREEEEEEQGLLQDVQKELTQLNIDDTTCSLSTIANGAFCDPRYLVQVFLEEACTEIGDGAFEGCAGLQTVEMASTIRQIGKKCFSKCSSLDNISLPPGLKAIPKNTFSECESLVSIDVPLGVVEIGKNCFHRCVSLANVSFVANDDSSSLSQLQTIGGGAFKCCLALRCIHLPSTVRSIGKSAFLSCVSLKDVQLPHHGLQVIQDHTFFFCEALEKISLPMTVYKLGTGAFQDCKSLLHVTNAQGLQHMGERAFKNCTKLGSVSTSLSGLVSIGYSALSDCHRIVQIDLQDGLTEIPARCFANCERLRYVSIPNTLDTIGTQAFSWCTALLGIRLPPTKVFIGNAAFVGCESLMSISISSCSMSSLPLDISATLFSKCKNLLSFTRGYDLRKVLCDRYADLPVHQACYDSWHTTVDDLTAAITAPSSERPTDFFAMTPFHILVTCAKLRPDLLQVLLDYYPAEVVWMKDISRQDILGYIFRNMKSLSPDANIFVEMVLEKTVLDVMHGYGLTSWRSDICSQLDSIIRSQGRDRWLPDLLDGVIGSLARYKKLEMTSVLDLALWKWSLDSFLQMDRAECWSLNRAELVIPSVVSFLWDESTLPTSIIGERSNRLVGFVGKSVIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHI4</accession>
    <name>A0AAD2JHI4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHI4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="283" mass="30700" checksum="A4A4A2307589AC72" modified="2024-05-29" version="1">MTELVVGESPGQLDKVILTIPEVDDDDLPSTFGDEDALLSVIDPSKAKRASSDKCSPPSIATTTTKSVTTVSIRSSELQLMQNPEGTMSVSSGFNIPKTCMQHLKLDFLSLGLIGRDGQVAALKDCLDRLMDGNASSSHKGELSTKHHLKQLVFLGGNSGSGKTTLSRSIEEIVTERYGGVLVEGKCEMQTRDEPFFGIAKALGKICIEVSNSGRDSKKLADELMVELGDKLEPLLEVIPELKQVIPDYKSAMLDADPDILDLENGLSRWKRFLLASFGLHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHR0</accession>
    <name>A0AAD2JHR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042280166" description="Dipeptidase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1951378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="66987" checksum="90F05BCB20928F14" modified="2024-05-29" version="1">MGSQYRIDPAMVGKSLLLMLLCLLSKEATGCTVFIVGKDASADGSVMVSHSNDGEFNTDPRLVKVPASSSVKGTQRPVFFSPEDYPRYVGHDRQVPEYYPTDGQTSFEPIGYIPQQVSSSTFAYLEETYGALNDKQLGIGESTCSGVFGAIPLGAPNGTALLSVDELTHIAMERATTAREAVQMMGSLAEEYGFYGAGEFEGTSESLAVSDTEEAWIFHILPDPTGKSCIWAAQRVPDNGFAVLANMFVIRQVDPNDDEYFLMSKSVHQVAKEYNWWSEEDGLLDFTKVYSDGEYSHKFYSGRRMWGAYHLACPSCNFPADYVDLQSDPVYPVWTVPDQPISVEDLFRYHRYTYQNTPFDLSAAGNLAAGPFGSPDRWKAGSGEKQVGGNWERAIGLYRTSDTYVVQSKKGSSLGGVLWFGPASALGTVFTPFVVQLDSIPKSFSTGYQGVFSRESAFWAACYAHNIANLKWSYAIQDLQTRQISLERKSIDLMKQLESDYQMSKDDQEDFAVVESAIMDNAASIVSSLWQLSDEIMFKYASGFVNEDDSHGGLSQMVGYPAWWLEAVGFKEGPPPPPTEPKCCNPPKAGKTAPVGGLRNAGSSSVVTSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHY3</accession>
    <name>A0AAD2JHY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHY3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36774">
        <property type="entry name" value="INSULIN-INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36774:SF1">
        <property type="entry name" value="INSULIN-INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="309" mass="33556" checksum="8893961443A60EFF" modified="2024-05-29" version="1">MRPLSPQTCVKLFVTGATVGPLVDSLHNQCLLKYDVLPISIVLPPMAMPMAMPIIENGYYDYWFTSSWTVPPLLGVAYVVLGGILPRLFEALLWKSGMVMMMGPQQQQEEVTTILQQEELPWESQPQQQQQQDEEPLKRRAILAVGTTALIIKLSEYLETTNNSIVDNGGGGGGGPLFNLLVLLSAALGQWAILDGSLSALLAASVTSIGGPLSELPFVGHGVWVYLDSARDYYPLAGLVPGSSWWSDNSSNGLLTWLLGVSDYTNLGLSSITGPCYFAVTMDAIALGRWFDAMQEKKEEEEGPASEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIS1</accession>
    <name>A0AAD2JIS1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS15002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIS1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="3"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1954410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="283" mass="31411" checksum="E8BC882FB033C4BD" modified="2024-05-29" version="1">MVLYVVGLGLGNEKDITVRGLEIVKSCDHIFLEAYTSILGGVPKERLEEFYGKPVTIADRGMCENDADDLIIEPAKDKNVSFLVVGDPVCATTHTDLILRAREVGVKVEVVHNASIMGAAGSCGLQLYNFGQTVSIPFFRENWRPTSFYPKIKYNRLGGMHTLCLLDIKVKEPDFDAMMKGKTKFLPPRFMSVSTAAEQLIEAEETTEEEAYNVESTLCIGLARMGQETQKMVAGTLKELSQVDMGEPLHSLIICGELHDLEFEVVKEFLIEGSSFSMEKQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIZ2</accession>
    <name>A0AAD2JIZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="3">
        <location>
            <begin position="276"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="377"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1211" mass="132857" checksum="4BF1CEF1E9AFB99E" modified="2024-05-29" version="1">MTGVSWFNGNNDNDGNGGKSFSIKEAAQALYPPKQGLIKASTQQGRFSTLLLEHGEEHIQDWAVIVYSSPISSSANPVFSNVSSPRHKKPPETTWAQGNSLQSSSTAAANNSNKKSKSKSKRKKYDKDSYPTVHMTKIEGRLHLCSKSIVLEPNDISRPIVRIPFSKMDEPPKEFPSSNLTTTTGDFDPMCIEFASTKHTICKANNCIGASEGVGCSTNFKVTFLHSSPTSCVKLCQQLFQIMQFYKPGHGTSPELEELLKPMLDRPFDPTNLYDVRERPLTSNLRCSIFTPLQQQRGCLVMTQERIYFQFAQGVLEGDSRAISWHPADIQAYARRYHGLKDSAVEIFWKDQTSTLLALERTHEREQVVRLLPNNVPCHTDREFLLQASQDWQKKIITNYDYLLLVNSAAGRSFQDLSRYPVFPWVIADYTSAKLDLTKESTFRDMTKPVGALNQERLNYFQQRYESMRDMEDPFLYGTHYSAAGYVLYYLVRSMPEQMLCLQNGKFDAPDRMFHSIDHCYRCVLSNHADVKELIPEFYNPNNDYDFLINARGLQLGATQTGDRVNDVSLPPWARSPRHFLKMNSKALESEICTQMLPRWIDLVFGSKSRGEAAKEAHNLFHTSSYMGPSDLASLATPEERFQAELQATEFGIVPDQLFIGPHPLRHETVDDSFVKPDIGRASFSGTEEGKGEGAWELLETPSTNFMDQPEQDQQPEFLNPIPTNSSESDFGSEGLNRHHPFNDLYGGTGPNPQKSRKNDHPGIPLSGTGDLSEKSDRTGTGFGGIPPALSNASSFSAGPLSPTATDHANARASASTEWDIKFIEKSRIHADTVSGCSVISGTPPNNQSILATTSLDGGLKIHNVSLAAKEAEESAKQQGITSTLSRFSYITMSRAAGSSSSQPKLSEFRSHTSRDALACLALISDGHGGKIAFAGGHDDVVFAYGITSGCAVASVYSHRDAVTGLDVMDRPYFVPESKLWRDQSTHIMVSGSWDATVKVWSVIVSNGETVSIDREPLAELFDADSPIVCVSSACVPNEESVVIGAGCADGSFCVWKIHGDGVKVVIHKEQAKRGSGPCSVLKWSTMSGKLHLFTGLSTGKVASFTLKDGSMKKISAASVGVAVQCLAYSENILLVGCSDGGLRLIPTREGAQFTTDLSLWPSVNNKSAPGLSCLSMSFVGNPTDGSGKCVCCTGAEDGSVALFELKRAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK70</accession>
    <name>A0AAD2JK70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK70"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14809">
        <property type="entry name" value="bZIP_AUREO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107:SF0">
        <property type="entry name" value="IP09280P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107">
        <property type="entry name" value="SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="420"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="666"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1958448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="910" mass="98427" checksum="CC177F9DF5F746C0" modified="2024-05-29" version="1">MSKAYDEFTSRDSNEEDDDDDDEIGALGSILSWDEDEEGGVGATSTNAALSDRETMQSTTLPDLVSFNMKGDGITSAYLQHFSTVPMNHNGSAADPSPSPIGGYQSQMSYNEGQSTAPQQPVEQKLEASTRPQALTPANAAQAQLQQQYQQQQLQQQQLNMINAQAVAQQTRQAQPQQTGLQGTSAATQQQQQQQVAQQAAVAQQAAVASNLAASQSGAYAMFQQNALLAQGKQQQAVGIAPAVTTMVMPNMAQAQTTDQRTDQQHTQYAIADPNAFLRQLQVAQLQQQFNAAAVQQTRPITQQVVATGQQATQVSAALQQMQYQGQLPIVSSVQVAAQSRQPAGSKKASSQKKPPQTASAPKQTRDLAAANKASIVSASDTDGEISSKVGSATTTIASKKSSSSMSKKLDLDTSHMSADEKARANRDRNREHARNTRLRKKAYLEKLKTTVDELCRERDTLVTERAGAANILVDMHNTRTEVLMSFFALRSANEKRRELWASILDESSFQCVLPVTPYRSFPASEVQVSKCQRTILGIDGMMADTASLHVLLNSLVDRSRFPNGTIVFQYTLVTEEAVIAGNQIMARWVMSTLNATQCGARMEVGKQGMLCCRFNSAHKITGVELMFDVMALMLQLKQAAGSETFSVIPNTVQTCQRSFDKPMVMTLADEPYTIVQVNKLWEEMTGYKAEEVVGKTSCRILEGEETDPTAVEVLMNEIRFKRPASAMIINCKKSGGRFRNFFLAYPLSTDSRITHYLRLSTHVDTVGEAKSIAPQIKQNVQYAASVATPGNIMVPSSMDGNRQAGSQPEFYGGVQASNPGVAATQATTEGAEPFQQPVYSIAPVLSETIPASAAGGMILPPALGANNMGMQQLPVGNLKRPNPSTNDSAAKQQKMSNNVDSATTNGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKS4</accession>
    <name>A0AAD2JKS4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002021">
        <property type="protein sequence ID" value="CAJ1959779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1963"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1625"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2017"/>
            <end position="2026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2508" mass="271834" checksum="3206FBF5E6B6DC1C" modified="2024-05-29" version="1">MNSELAAAFAKRRSRQEQAGSDKKKKLPSKKLDQHLASSSSTPPPGDDASKSSWARSTKSSVGSGETGGSHQRRQVTTPPESTHSRSGERRQQKNSSKSSKSGKHSVSSAASSVDSSTTGDTPSESKQQQQQQRPNWEEALAQAKSFQSNSQDPPKKTPVKENTSELPPQDPPESAPVEEENTFVASSQTGEAAPASSAVPTVEAQDDTRVSAFKSTTGAETDDSSSEEDEREEPRFEQSQPSLFASNEGFAAFPQDFSNAEQPQFEETPASNFASLEGATLDKFEKGPDSFGATFESFPADFAGTQSAFAAKDEVVVDGYVPPSFELPTSSAVGLVDKSPIEDPPVIPKPSKALRFENKEKGCVKIYTNGKLPTAPTANPLNGNVILAKRDRKDRELTLCEFNPHTKVQVASIPVLSMDLQRKVAEKFNVSVIGVDNVVTIACGLHTSSSGQTRARVGCLLDLLVLENNEVLRVIATWQWGYAGSIDSIQLQSLLSPPSGSDFSYNATSLLVADSCIFVSGASAKGPCVFLSKPTVRETWTANFVGKDPTRIASMAVTTTTISTTTKSKPQRLPYLAIGLTDGSLSIWTYQAATAVNSKTTETLRRLLYPLCRLDVRSLKKASATKLSGVAVHDGDTAADANVQQTGEIGYCTRLEWSGPNPTSSPIDTLLILVAAFQGGVLFYHVSLPKIKDKAKRAYVELKAPTNSTQLGSTIVLHPVAATRWPAVYHKTAVSFVDVGAHMPLTVAVLATGLSTNLEYSRLGLVSCILAPYKGSVKDLPSGTVHVWDSCEWSMPKSSADIPPSELMSCTNLPGVLYFSSTGLEVLRFSRFAHCIMRNPTSIPFGLSTSGTTYWGDAVSDKAGTLHVYTTCHCERRKVVYGEGSSEYLEWSVPGRRHWLIQTACGDCKEAVLDDVNQRVKQKKDDDTVYGGTYSKVLVELTPTDSASNLIPFRISRDFQGLYIAVWFENIIDGTQRIALVERVKDIMKVAHWFKDEREIVFLPNAMDEDEVTPIPQMLVVNSNGGSVNLWCRKQRKTSSKHVWQPAVGVECRPILGLPSSDQKGGEKVDIESQYVDVLRMTTYRSQDQVGLLVAGRGQDRRVCILAGPLQPDDDLVWSDLLPNLEGDPCIWLEEDEELCLVVPLPGEKAIRGGIAIGSTKRIMVLSASLEIIAQVDVSLPPTSLVPLGSFTVGYCSQDDHAIKYLSGVPSAFGCTGLIASLPLPRHTYSPHLILAVRPDRIIYTCYHNGSRLVERGQSTGIFMLPSATTRPALLLEPMVANAIATGGGAETATQPFFRTVIEKFGRKVSTMTHGDNEGIGNLGAGLTPKVFDLLEQYGLEAAASWLLTGTVNFGRSTNSRLLPSWMPVSAKAKAAMGDADTLMHIIANGDQYFSEYIKSPDSNMASTLPRPTDPSAFLSNGYGMNALKQGNFVDAMKLLDIAGTENSDAMVLQLSLALQMDHAIDATPVLEALSQSHDLSQIGKSIRSTNAASLAALSLELRKNMGIPNDDFRYKWIRPLAPSFQRGKKFGRLRPRIIGESAFSKMSKQRVRAGDELFATETSEMKLVWNEGPNKEKENLLVLDNMHDWFGRRKPAILGKEGVKSAEVRGATTLADILRKEDDDSFGDQDEDETKDGWVDGVGEGLKDEDKLSAYFRLSEGDDEESGWRTEGFADITKFENRAILVGCGDTTALEVSTSSVDEGESGKVKALYDLVFEESGVGIAAALGLPAPRGGSLDIGMMHSPDHLARQKCSMEFWFWVPASVKDSIVLMRRTYGVSADNLESVCKASDKASVLWELILSTNGELEFRTVSGSSLKTTPHTASDDDDEEEEIKSTIRFGYWNHVCLTFKQESMTSSKVNVFVKGASAISDTLNFAPPKFEIDDFSGAAALDPLLEKSYVAFALDHPAGFRIAELRAWALERAADDIRTMMTEYLYCAEIKKKFAVRIKKKGGASAKVGLLARPKGREQQSTTPQKGLLAPPKGSASTPTGMLAPPRSSEKARPRKGLLAPPKADEREESKIENAGFGNEGFGFGHSDFGATESVPPTFQDTAANAAFSADAFGGFGSKDSMPVPFNAAFGEGSNFETTGPISFVDQVEEPGMETFEESPEISPLWDSAIPLSEQVRSSATAALIRGPPATRHFGGNRGGLPDYRELERFGVGAISICGSEKTIVWRDDQIPPGLTYPIGASGAIVSDQMDEDGSEFLCCFLAKDKRMVVFELSTRTVVVELQMTTKLNFWRFLPPEAGEDTLCFMLVTPVGGFHWMPLDESPRPRQVWKRGPELQGKKIVCYEEGGTNGLDGPDMLSKVGMLLVTNTAVGGSVEAWLVPICGDSLALCAHDNVLGACLCSPPDIGYEAWMPLLLFVVEAEEDLVVCISAVTETSEVSIGLTEVMTDALIELGPYKGFDYEPPTLAMGNWPEVLCCSLGTTIVIIVRKKGLVVAYELAETGLELIAQENVGHFVVDAVMRYSAAEGGAEIVLLMSDEDNPKDGRVGTFCFRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKX1</accession>
    <name>A0AAD2JKX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002030">
        <property type="protein sequence ID" value="CAJ1959916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="721" mass="79188" checksum="2BAD571A7BFF80E3" modified="2024-05-29" version="1">MIFSIVCSVIVAVRLKDDNKMPVQTLQHLVEECMSSDNREVKELATLVSCFVVYVLDSSFHNAVGMTTQEHFARRCSQLSQMQETRKFPAYSSKAKAQVQWTFAQCYNELWLQTKEKHQRRIKSSAQEYPFVTRTQQVPRHIRKKRRNDKTTFYLYKNNEGKAGAFIQLLEYRKDKTWQELYFLACTQWTEHGFVLGTLVPSRAIVPEPDLLTRLTPPRTIARSRRTIVTPEVTPLLRSNVSAMVQNGVAIGPNINNTNTIPFHLPRSQVAFISANQQWQAAILLSEQMCTPESRTGAAAVQPAHPQQSLEDIVVLVALVTLTPPTPPTPQEPIALIPMTISATQQRQAAILLSEQMCTPESRTGATAVQPAPPQQSLENIVVPVALVTLTPPTPPTPQEPIALIPMTISATQQRQAAILLSEQMCTPESRTGATAVQPAPPQQSLENIVVPVALETLTPPPTQETIALILMTKRGVSMPPVQEADASSTSATICVGMNQSTAGTDGSKHLATPQQADTTAAEAAVVLATIERIMFVSTERSTASSDEGQNEEPNDKGALDAGDTDDANIDKGETVPTTKCSNKKAKPKKKKAQSKKNPTAKTKEPSVIATSIAIANKEWDVCGALALPKGHIKSYKKQLLELGGGRIEKLRFCQLYCKTDLLGETGAYYKEGGTTAFYCRDFLKYGGCCQECFAKKCESGLTVRRTRGKQQNYAILHNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKX9</accession>
    <name>A0AAD2JKX9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002033">
        <property type="protein sequence ID" value="CAJ1959929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKX9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="126" mass="13155" checksum="9EC54A7827F14C0E" modified="2024-05-29" version="1" fragment="single">MEQGNDPAQGNAVPDGANQGNAGGNQPAAANQPAAANQPAAAAADPQQQQQMIAQLIAQNTMLVNQLTNFMAQMQQPAQQPVIIVDLHQTGTAYNLAQRNGLAAFQEASAALLHKYDGSNATYPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM04</accession>
    <name>A0AAD2JM04_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002078">
        <property type="protein sequence ID" value="CAJ1960886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM04"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="168"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="288" mass="32147" checksum="D6C39A7AF88BA189" modified="2024-05-29" version="1">MQSKQDGPLVTQQQKSPLLTVEVCLAPVEVVQPAVPQQGVEAEAVVAAQNLMPAVPLAPEQPQQPQQAPQQPTAPPIQQEEQEEHNNHTILVPNEQQAPEPMTIGQELVLPTPPEQQQQGPRPVATQHGFEWFDAPEGIVIGNPIRQRKWVLKTPVNDEEICDGCDIGFSRSSSRATLWSTVASFKYIPAPAFGRTGMPHNRFDSIWECLTFSRQPEQRPEGMSAEAYRWLLIDDFINEFNEYQAANFIPGSTICVDELIARWYGMGGHWINEGIPNYVAIDRKPENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM44</accession>
    <name>A0AAD2JM44_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002120">
        <property type="protein sequence ID" value="CAJ1962787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="13045" checksum="2E46DD12372EE29F" modified="2024-05-29" version="1">MRQNVLSGVNIGGIEVGGSSSDVKAETKQKALGGKASDRKTLFYLKDAPGATICCVSVSSSAGGQKACGEKKDSATNLCDIASHSSLVLIDKLQFPALYCCCKKLGRGGETFYWDSMSHVGEMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMC0</accession>
    <name>A0AAD2JMC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042223294" description="WW domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="983" mass="109267" checksum="61F78CC169A2ADD0" modified="2024-05-29" version="1">MRTLFLNHTIFIVLIQLIGTSKAEKPPALIQFSFSSEQCRNGTFQNVGAEFESSPPFFIQRNERTTGCPPGMGVEASDMFATTTTANATDVAYLQTSQPLVALLQQNSTSAVSLSLWIQIPQTDVDTQTGPLLAIGQAETEQHDGDEDFQTTECDVKQVDFELSIRNGNVVELLYRTNDPYFEPCARMRVTELPLLRGLNHIAVVLEDGHQQVFVNGMSSISRNDPFDTRLRHWNEESLLYMFSFPGYNYPAWPGRLLHLSINTEEWNGNDFLADMAEGLPDAEPIANSIMYRMDEDANVISEDVLSPVEHNTPASLQLQVEYLNHDVSALLKALNATQPAVLLQELKYYIIQPPSRGALYQVDGPKQTKVSSTEGAPISILGPNLFYLPPHNEHSEMPGSIYDSFQYCVSKEAIFASSQCQSMGTIDIVVDSVNDPPTTSISDVPYLVHEGIHEEIKGLWLGGHDVDRNDGIAAIQVTEPPKHGFLFLSVPTARKDGLVHGTLLADLNHTILGQEVFLEYRYTGANQVVQSTMVHDSFRFRVQDRNGAWSDEAEAAIWTMPSLSIGEPMEFHANEMEPLIIRIEGQDESGLDRSIGYFFEALPSESHGTLFDEQSKRLTANKVVLPSLAEPGLKLKFRPSHDACSDPMVSTVNATFAYRVVALSSSKTVTSVSSIMAHHILVKCAVDPLRLSIGDDRYRIEAFSGPADDICSGYAYNASVSNFSNCTSAAVITTIKVKASKRHTYRALISIEASEGFLTLDRNQRSRIGAIRGPVEMRRTVDFLAFPSDLEEVLGNLHYQTAIPGNHKIKINIKSCEDGNPFETLNSRDCHVSTASISIEAVEPEMNLSEDKLYTKFPWFSLSFTLTMLFLFKSKGKMREALEEWKDPDDGVYQWREHYDASTGYYYYENLEDGRVTWRAPLNEGILPSPERGLPAAYTDPWGDDGLSETGSLISVSLTEACDSDDEFTLDDASVNSLTFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNW6</accession>
    <name>A0AAD2JNW6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNW6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="406" mass="45047" checksum="A1932340B50398B6" modified="2024-05-29" version="1">MYQQLDRLDFQDPFSVQVLAPEGAGPGAQEGSSAADDWYLPAYVNIEYHHPDGGGHIKSLDFHNCSFVSIPDSVWGLPSLEKVEIHAMEDLISLTTVTSKDNTTTTTTTTLQKCKLKELIVDECYSLDKLPPLPDSLTHISIKACHRMTFLPKSIVEATNLKVLQISNMMLPMGPSLPSTLEELKINGSEIQIRKLKMYLAGDGCGAMKNLKSLRLSMCDLNNEHLKAIWREILPICPQLQRLNLSGNNIRSLSSLVVVKTTPRTTKKSPTRTTRTRLRSLNLEGNPVVNKHNDNNNNTNEESNHLLTILEQNPELCCLGGDINWKLPLYQNHSAALQKALDDNFARILKASSSSCPLALWSNVLQCAAANTNSVKNNNVEDHLAASLIYNVLQGPAFVERLPHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPD2</accession>
    <name>A0AAD2JPD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS23703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="857"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1121"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="868"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1167"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1969428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1427" mass="156383" checksum="92C58C21CCD78974" modified="2024-05-29" version="1">MDLLAQVSADTSMSMEVDTETPVVKAEDGAESPSTTKVSSNTTPHKKVKKVKKVKALESQTPPSPATDQSATKTVVKTEAAAAAAATTKATKQEPIAEIIPPRPVYSTWRVRDAAHFLLQEKVPPPTKSRMNLSSQFDVDAALERLKRDKISVVKKAFDAAASTILDHIQQGSNNDGFYDHESIQDEDLPPILSDVKKLQTMRLASIERAYDNKDPTKRKLARQQETPLNLSSLFKSKRSAKKKTEAPKFTRNTPASSMAALDARLTSSRAILCTAANVTFESLTPPLEGLEVDISDVPQNPNKAGADKSTHKEDGDDEDDTTDAATVSNMGAVVVEAQSLGQRIEAVAENAAKRSSLRYKYRKDNARFDKPVKPFFQMKNPFAWKEKEGSDEEEDDDDDDEVPMYEYNPTGEALTEAWTTVCRPRLLSILHTGAGHAIYHDVNWPSRHGRIANLLSKLTTKDNNYGPHLIVTVEPDVDRFAQEFRPINSHLRLMSMDNVDSLRCLKYAGTSSQLCKLRKQFPDANGLPEAPFHVIVTSYAQFLRDYLHFCQMPFEAVLMDDGVSWLAAAQGDPNSPMGKIWDEAIWSKSDHQMGLAGTIEKEWDYSVDTFDETTIKEAWVGLTARHRIATSSILKVQQRASLDTLPVERIVNFILPHFAEVTREEWDRSRITNDTASMKHFRKLLTRAIVVHDSTNEDLDPYKLAIEALQGDLPSVEKSNDPEVPELIPDETFVSDGKVAASRRSALQWLGSSDESWLRYELGSVQFKHILEAMKNSSSYGHICEEIVTASILTSTGATGQVAGSMAYRPAVRCGRHFGSEQGLRQHHSALHAPPGTWLCRICSVDCVTSQARTHHERSCGQPNGGLDSSNGLGASTSGQIGRGGAYKGPTGIVGKKKSNKTSQANVPVKEKDSDGSIRLPGYRGVWVNQAGKHFVKVDGARVSGEDSDVIYFETADEAAKKHDEFMKSKKPKGKVEYNFKDDGNRILYEDVSTTSTTGLGGGANSVVPALSVINIKDLPPEVKPLLRDPRQTSRTGGNSKRHVYAYRGVCRQARKGHDRWQSQISFMGVNHYLGTFDSEWDAAAIYAWAHLILYGEEATKQAQKEGEEAAAAYEQEKKDIAEGKIPATPPKNEKKKKQGGKKKADGKDDDEGEGESKTGRKRGRATKDDAGGEKKRRASADKESLAPILAKGVGKAVVLAPRPQFAENGDMQLTSETATRLLAARKLRYCVSDANEPAPIAMQYRPCLPGNPDITNPAGAMLVGLSSVSFGWDDKEYVANCFDESSGTNADRALSALIAQYSDQGVNDSFRTLVQGTSTVIGCASERTRRMNESLGLRSAAIGGVIGSMDCHIGGSPIGCSEKAAYIRYSPTDSSDFQFCALSDNDLVTINGRRITPKMGCFPLCNDDVCTVGPRVFAFLLPTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPH2</accession>
    <name>A0AAD2JPH2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPH2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1969955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="389" mass="43823" checksum="728E4FBF6271484A" modified="2024-05-29" version="1">MKFLTDAFASDHRTRGQSFWDQLTGLPHKDSLIHDHIINSRRGMCLDKTIHQSFGHPVTDTTKPGYQVTCPEDFEPEDQQMEELEQQFDQWNDPTLTFAHRMKNGETMSPGFALLVRKGEDGQPCQIMFISNPVLTKPDVMEPNTFGAPAPFGEIVNNDLAQKYVGDPTKRTHCLLGLLSGHTFASYGIGNRIEFSNSLLPVLMTDGAAIRNKPLNRDDWKILFFPAMSACPVGFVWPASDGFEAFQESITNRKKIFTGLLHLLTSRKTIIENWFTAVKASPASFAVPVVDALPFWSCFPTEHDPVDACVLDVALLAPFQEQMDRFLQSHLMQLIYRSGSLPTSTLGFKMRAWVRMHNMRVAESYPSALGITLPDVWKVLITKTMVKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPV0</accession>
    <name>A0AAD2JPV0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002519">
        <property type="protein sequence ID" value="CAJ1970452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="182" mass="20692" checksum="6572D41068ED167D" modified="2024-05-29" version="1">MVDSYQRMFGQKPKTNMWSPLEKGDHPECDTSELLDSDGVTQYQLLIGQFQWAVSLGRLDVTTAVMTLSTFRSAPRVGHLNRAKRVCGYLVKFKEACIRFCTGLPNYSDVPEPVFDWANSVQGCLTEEIPSNAPPPLGLAVIITHYVDANLYHCQDRPVGYGYNLHDEWDSNRFLFKEKVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JQ88</accession>
    <name>A0AAD2JQ88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002447">
        <property type="protein sequence ID" value="CAJ1970014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JQ88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="65252" checksum="F493B5EB4D9EA52A" modified="2024-05-29" version="1">MACRKRTIREVASSHNSFKQEAESAENSDFARPSNGDGKPEDSCKKHCVAINREHSSALFTPSSMILSPDAVKEAGLKILLETERLVNPQHQSDIARNEDDGNDEHEGENDTNNDTSNSNKKTRQVAAGASLNLPLVPDQFSPHKAWSEQTAKWSYDVLDHLQLPREIVYLSMHILEKALLASDSAGGTGGGGACSDINLDDSGNVSNDSGDSSDDSNTAGGSEYRFGITNKHEYEKIAITSLYLAVRLSTRQTPPTSQEPGYAPLQRKLQISELLSISGSTWTEQEIQECSSLTLESLGLWKNKASDITNWNFQLHQAMVQATPHSFCKLLFFGFQKKGDDQEQQRDGTMVADHAFVPRQTRLAWLELALYLIELSVCDGSCHRLLPSVVALSSLQAACKILQAKPGAPPASSFQASKHVIEETLRKAKGVSELPNTTFVANRLEYIYQLSQNNGNISNGTQGNNPRRNAGAGGRNGRSNARIASWSCPTLVMDDDGEEEAEKQQQQEAAAFVANNRNNDIVYATRGTIASQTEEDRRPIQYIQCNLDMEQASDRKHRPISPCPMILDHIHRNNSKSNINNAKKAAAASKALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV86</accession>
    <name>A0AAD2PV86_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001849">
        <property type="protein sequence ID" value="CAJ1954033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV86"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="154" mass="17702" checksum="D65AD4EBE07FA1E3" modified="2024-05-29" version="1">MPISAIKDDGYPQYTQYEDHSQEDPRHKIEDDFEEPPDQEGDPVEFDKYVSAKVSFNADGIETFGVVQGRKRDSSGKLIGHYHKNPHLDTSIYQVEFEDGKVESFYANQIIEGIMMNVDDEGNTMYRIRKFIDNQRDGRAVKGDDGWYTTKPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVW3</accession>
    <name>A0AAD2PVW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVW3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF2">
        <property type="entry name" value="GTPASE ERA-LIKE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="798" mass="89816" checksum="25A52B0B745D1B28" modified="2024-05-29" version="1">MSKEDPPPMKSPPTFQIKVALIGNVSAGKTTVVNALFRDKFGEVSMKRTTAGINEFAISSRNEWALVSDAPRDSHSVLKEITQDNLELRTSEEVKTKRFEIELDEALCDMRKDTQLVVVDIPGINEADMSKKYKNYVESHWNTFDCVVVVMDGRQGVNTEEQVSLLRFVKSNLESKKDVPIVILCNKIDDQDDEEQEELVLEAQREVEKIFGVPDRQKSLQEVLQATTASKETTNGTKKHKWKKKNTKPSDQVSPVFIPISGVTAFIFQTCSNMPLERFREFDQKLIAKLGRDRIGKFRWKKLSKEDRIKEAHEAVSDPEGYQAGVADSNFDKFLMVLSSLVGGKTAQEKMIQNQIQVSLSTISSGPGIVEKLETIYSTVLALSLGDSEAKNAHLSEIKSTFWRLYKGMEQSCFAKEKSSTTLNSFGPLADELKKYRDFATAVGWNSEADLSVVFLKNAVRRFLKSMKSTPGFVKDLKVVYCAIKEMSLEAEDSPIVEALKESFDRLFHKLTEEKFAAFASADAVGNLSVLGDELVVYSKLATEAGWTNEHLKVAAKFKQLVLAQIGSLCELASNGPSQQVFGYPDSSRPTSFAALSWLDWKLVLRSILLVRYYDRQFCLDFGREIILMECLLESEPEVRAEKNDEQCTRCQSVLTFNRICTRCSRTQHNTSVNLEREKKYMCPSCVGQELDCNRRCGNCHVFYHPHSEHATFSVCPIDGYSLDLYTGKCHSCCKVWKQFPNLPVVKIRHDGNGLALSGSQHVVNIPSLLSDPNHFGHLAWRYCELMATGVGQHSGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXM9</accession>
    <name>A0AAD2PXM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS22469</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 12"/>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXM9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="236"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1966884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="666" mass="74364" checksum="C52677E6741D3EBC" modified="2024-05-29" version="1">MSSEAPAVHLDENGQPLSKNALKKKLKAEKAAQAKAEKAAKAAQNQPKKKEKEEEITDPTQFKANRQQTVAQLQKEGVNPYPHKFNVEYRLPDFVAEFESKTENGAKLEEKTVSVAGRIVSLRAQGKLKFYDIRGDGAKLQMMSDPGTFAGDADAFAKIHKILKNGDIIGIVGYPGKSKHGQLSIFPTEIQLLSPCLHMLPFSKGDSALGGISNMETRYRQRYLDLIVNEEIRDVFSIRSSIITEIRRYLDDRHFLEVETPMMNMIPGGAVAKPFVTYHNDLSMDLYLRIAPELYLKMLVIGGLDRVYEIGRQFRNEGIDLTHNPEFTTLEFYQAYADYNDLMDMCEELVSGLVKKITGGFKIKYSPKPGMPEVEIDFTPPFKRISMMEGLEEKMGIKLPAMDDPECEKKLVDILADFDLECTPPHTTARLLDTLVGEFLEDNIIHPTFITEHPQIMSPLAKYHRSKPFLTERFELFAAGRELANAYTELNDPVIQYNLFLEQAKAGSAGDDEAMVMDDSFVAALEHGLPPTGGFGLGVDRLTMFLSNKNNIKEVLLFPAMKPTDEQMQVIAKNAPKKDATNTNMSMTTDMSVFEGADMTSSEMLKALDDALIGKSFIQGTAPSKDDAALLEKVSKVDASTLEAYLNITAWSKLLSMFSAEVRASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAW9</accession>
    <name>A0AAD2CAW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1893416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAW9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="87"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1893416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="311" mass="34144" checksum="F99106DA73AD7010" modified="2024-05-29" version="1">MFRPSTVLSRSRRLAATLAQASHSGNSTQTTTAAAKASTRYLHQVASAASGNNSIHNSSNLHGNKSKSIDQFPTASHQQPQYRTVFVQTENTPNPESIKFVPTNTVVLEDDGTGNGYFVNKSDPMEDILKSPLCTELFKIDGVKAVYLGNTFVTVTKFAEAKWQFMRPDIFSCLMDFFESGQSALVDQPIITDTTIMDDDDEIVAMIKELIEQRIRPAVQEDGGDIRYISFDEHDGLVTVQLAGSCVGCPSSSVTLKQGVENMLMHYIPEVTSVVALEEEEEDGEGNEVEEVKTQKSYEERLAAAGIPFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CB84</accession>
    <name>A0AAD2CB84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein xylosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peptide O-xylosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CYCCA115_LOCUS348</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>UDP-alpha-D-xylose + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
            <dbReference type="EC" id="2.4.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 14 family. XylT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.26" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1902270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CB84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030158">
        <property type="term" value="F:protein xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043538">
        <property type="entry name" value="XYLT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025:SF3">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042294945" description="protein xylosyltransferase" evidence="20">
        <location>
            <begin position="16"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAJ1902270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="461" mass="52700" checksum="37F3A895AF9DBB6B" modified="2024-05-29" version="1">MRAILLILLIQYVLCGTCSSGDVVGAEDIHDLPDDPHWSSIAHDDVDCTCEERSQQQQELQELCFNNNPDNTNSTTMTSCGARIFYLIVVHNDRTMNDALYLFRGIRDSRNTILIHIDVKFGMKPYESSVLKQEIDACPCGSQVEIASVHNSSWSSWSMNAPTLWGLDKAVKEYEGKWDVFINLSGDTLPVYTPDRVASLFAGPLAKTNFVTSHSCETGLVPAPIHFFPKKWHKRGHYSQDPANLTYVDDDGVSHSNYAPETYFGSQWMVLQFDWCQLLVRQLDRPDSLASQYKEYLIATKKLMTDETFIPTILMHYMPKTIPEIDEEGYLDVDEVDMYAIRYERMDENMPNSQGVYTTVQRYNVPENSGVDAPHAWGPYFLGVYDLENIRESGALFIRKVSSVIDPNLFRLLPVDQPEDIPLIGWPKEVKIDPAVDWAHRLADFKKKYIHDHPEVLQKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE45</accession>
    <name>A0AAD2CE45_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1903128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE45"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1903128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="199" mass="22685" checksum="49F69C22818EF73B" modified="2024-05-29" version="1">MMTHSSRIEICGDSNRVERQKPRALKPYMNDEAWERLCNDLDDAMQPWVALTRLSSRIARALGGMFLVFVIVYTAVKVTNLTAAEVDITAYVLFPMLMFVVAGSTCWLIRVLPQTNGLVVERIERALEGATNQVNEHMQHTRIAMEYQEDEVNRSNGKSIKWIQIRIVNEHGEVIQTEEDHHEEGDHLGDNDDGSFTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEC6</accession>
    <name>A0AAD2CEC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000186">
        <property type="protein sequence ID" value="CAJ1931864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF498">
        <property type="entry name" value="DNAK FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="134"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="650" mass="72651" checksum="F262F28EDE374FEB" modified="2024-05-29" version="1" fragment="single">CAQIHGDETEWIDLKTAKEAYPIQVAKYAVANKLVSEPAFSWWVPYTLKKCDRILKAVKRRALTRKTEKFGLELPGSGPKGVRCAYKIDANTGSNHWGNAVEKEVKTVLPALRILGPNEPVPPAYTCIDLITVFDVKMDLTQKARICAQGDQTDPPLLVAYASVVTCESICIGFLLASLNGLDILSADIAGAYLNAPCAEKIYTVLGPEFGDLEGRIAVVEKALYGLKLSGFSWRSTLSKTLREEMEFEQCCGDMDVWRKPALKSNGKKYYEYIFVYTDDLMAVSENPRAILEKLGTHYMLKSDSIAEPTTFLGATISKRFVDPSDSRKCWSIGLTNYLLEALRVVKSRISHQKYNLNLKRNVSAALPSGYKPELDNTDFVDAETHTLYMQLIGILRWLVELGRMDVCAEVSMMSSYNAMPRVGHFHAVLHLFGYLETHPSREIVMDSAYMALTDIPKSEWHEFYPWAKEVLPPDMPEALGRAVKIVMFVDASHASNLVTCQSRTGVLILLNHAPIVWYSKKQNAVETSSFGSEFAALKTGVELVEGLVYKLQMMGVPIDGHCHTLVDNNSVVMNASRPESVLKKKSNSVAYHYVRSKCASDLIWVAWEGTKTNLADTLTKIHTGRERARLMGFIMYEEDKIPRVVQSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFF1</accession>
    <name>A0AAD2CFF1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Superoxide dismutase copper/zinc binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="160" mass="16280" checksum="4CB1FEAF060A2BC1" modified="2024-05-29" version="1">MASCTCTFQQEASSGVSGSLKITQDSESSSTVFEGQIRGLTPGQKHGISVCTYGDLSEGSASCGTSFNPFGKTHGAPKDDPSMRMVGDIGNIVADEAGNAEIKIEDSMVKLYGPHSVIGRSIVIFAGEDDGGKGGQEKSLTTGNPGPSVAFGVIGLSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH83</accession>
    <name>A0AAD2CH83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LSM1</name>
        <name evidence="9" type="ORF">CYCCA115_LOCUS2062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved with other LSm subunits in the general process of degradation of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH83"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="8">
        <location>
            <begin position="93"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1930737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="206" mass="21454" checksum="D3C417CBB384AC12" modified="2024-05-29" version="1">MASQAPPSDAAAAPTDAPAAAAAEAPTQTTPNRNQGGGRGGGRGRGGNQGRGGNQARGRGRGRGGGDGGRGDGPVSIAPNTGIPYGHVPGYLPGSSSLVEELEKRILIVLRDGRHIVGTLRSFDQYSNLVLDESTERKIHRHKDGTVYFSDVPMGLYIVRGDSIVLLGQAAPDDGMKKVEPAELDEMIKGSGQAALEWDFDKDLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI21</accession>
    <name>A0AAD2CI21_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000413">
        <property type="protein sequence ID" value="CAJ1934916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI21"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="129" mass="14485" checksum="0DD787EA58F9FD1A" modified="2024-05-29" version="1">MLLEVQVSSCSDADPISHKNTVNGSVRHPTLGCRWVHQIQCELVMGIHSHPLAQLVIGSSKYYPHWYPPCLDDMQRPPQDLKDQPRAHQSETLPRILIHENLPSPVSSLPPDFAQHATLLSDVAEHLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIY9</accession>
    <name>A0AAD2CIY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endonuclease V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS3792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIY9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2170.10">
        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511:SF1">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1934452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44524" checksum="55985A935EA5C70C" modified="2024-05-29" version="1">MQPEPKRRKNGTTTNHTRTVSVTMTTMATGDSKKRTISNSQREVWKLEQEIVASMVQMEADPPIDTSVVPDNPLFHVIKDDHKDVYSFSSNPEFYGGVDVSFPENEEDKAVAVYVIIDKRSLSCVYRDYKYFNLTIPYVSTFLAFREIDPLQELVHRQVREYPDMTPKAILVDGNGILHPRHAGIACFLGTRTNIPTIGIGKTLLYEGGWTRERLAAAIDDFLQNLNDTIGQNSQTLPPQLMHVRGTIVQRTSPDPTNGEAMSPKTASKTNMQEPMDRKTLVTELSHFCNGLAIPLSGADKRFPILGCALVGHGGHSNSKKSNQLSSGGTIKPIFVSIGHRVSLTKAIQITASLCQHRIPEPVRIADLYGRELMRSSDKSNVEVVDPMQVQGDREMAATMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNI0</accession>
    <name>A0AAD2CNI0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor Tu, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS2161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNI0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF22">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="37"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1930937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="423" mass="46317" checksum="0EC73C43837C1DE2" modified="2024-05-29" version="1">MLSRFATTSTSVFSRLNSSRHALNLSRGLAANFDRTKPHVNIGTIGHVDHGKTTLTQAITKVLSEKGWSKSMTYEDIDRAPEEKARKITINTSHIEYETANRHYGHIDCPGHADYVKNMITGAAQMDGGILVVAATDGPMPQTREHILLAKQVGIPNLVVFMNKCDLVDDEELLELVEMEVRELLSEYGYDGDEIPIIRGSALAAAEGKNPEMGADRILELMDTVDATIPEPERDMDKDFLMSIEDTFSIAGRGTVVTGRVEQGVVNVGDELDVVGFDMDAKTTCTGVEMFRKLLDKGMAGDNIGALLRGLKRDDVRRGQVLAKPGSIVTGTKFEAEIYALTKEEGGRHKPFMSNYRPQFFLRTADVTGALHLKAGTEMVMPGDNTTVDVELITPIALQEGLRFNMREGGMTVGTGIVTKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNI2</accession>
    <name>A0AAD2CNI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019309">
        <property type="entry name" value="WASHC3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10152">
        <property type="entry name" value="CCDC53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1186"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1583"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1675"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1782"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1949"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1433"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1684"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1710"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1741"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1792"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1949"/>
            <end position="1964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2003" mass="229050" checksum="557C965650CD8BF3" modified="2024-05-29" version="1">MHRTAIQSSAASSSGSSYPTIPSDYFGDGNDQSRYSNDDTVTTFSSSDIRHNNRVQRELHRAIRDSIVAERILDRQARKKYPLTQEEKEEQRLAKRQWELSNATLKKIAGEQEALLQLVAKQRISEMSEKKRMEMHPRMQQALAETITKKTERGGLVQQVFNENTPDIGDFIQQQEDALQTVRRKLRHQQPPAEAWEWEQPRQQHHYHLQRQQQQQQQQQQVQQPRSRDRVGAYVAAGRHQQYPRQNQKVEPNEADLAAFVRLQDREYRAAQRRTYEQRQQDREYRQQHNQSPAMSFPSQMPSPLTPSDDDRHHRSRTTGGATTPVSQESYGRYVERQNQELQKIAQTKLGASPKNIPLAASKPMSVDSNPSPTNSDLEVANLFRNGGGSVSGGSEASLDDFVQEQRMALESFRQVSSKSSHASSRTLKQPQQPPSVVPSRLAVPDLPGGGVAESSRLKQAPLETTRLQQAPPHGMLKQPPQSSFSSMQPKPPRRCESPSVGNGSVANSISGSQAKAPLQPSRPVRRRSSSSSTKPKPMDSDDEVSLPPPPRKVSRNPFNGSTSNRSSLTQRMKKPAPPLPMTFQKRPSPQKKMSPPPRLVYEEAARSAQHHPQYDQPDPQQKSMIQNNNSLSTKKAPPSVYSYNQNYQEDGSSLSRSIPSAPHLVDLHDSKGNILSPNYSIDHSLSLPSAMTDINSMMIPEMDEPSVYRDTYEDDDEYMEEEVIEYEEEEYTEEEVEEGDVNMNIIRSSLGMNDQSCCLRHPNQLICEYSPSFRFDLVNTCKVCSSERQAGSSQSTSSLGASKEMAKVIGDIQQLQSNKSQWRRKTNLMYYGDSSYQSSTRTDVVNNTDGNNKKDANLVVPLLESDWKNQVIRRVDQIQSWEKVTALKYNPRSARFFRMLKMGVPMGAVQIECELEGCDPAILQFDPERTVTEQLEEHCPNDPDTQANLILKFDQGSLLEDCTAAEVVDVITKAFETEYTRTEEKKARKRKRQPNVPPTLRELDFLPQATSEENIRQLEQEKARADDASKRRRIEEEARVRAEEELESARQAEKAAREQVEEDAEEIIILTQAQMLMREKADDASRRRRAEMDARLKVEEQMQMMKEAESQRRQEQEVMANEVQRLRKAEVEARLKAQDSSVRRRAEMEERLKAEEELRQLRETGIARNEDVQQTAEELTRLREAEATARKKAVDSSIRRRAEVDARLKAEEELQRMKDLDLKRKTDLERNDREIKQLKEAEENARKKAEDSSIRRREEVEARIKAEDELKKLANLESRAQKELGDLASELKRLQKAESEAREKAVVAIQSRREETDTRKKLEDELEEIKRTEAESKEAAEKNAKKLKKERSALKDLKKEHDRRLQELDTAKKEAEERAQRLEEEKASMESKLKSEASEHSASIRARETEALRRHEAEEATQMMIAEQAKHLQEEIQKRAGAEERALALEQEKESVEKQLAFQEGARRAIEVEVAQLKAKEQDRIQAVKRAQKKLESVEKEKTAVAQKLKLEVETRQIAEGEVAKLKAFQTKRESEGQQREEQAVATAQRQFELERLRLQAELKKEEQARLEADFARQAAEEEVRRKGVQELKSRSEATESLKREKDARLKVESEAKRLKNEAKMAREMIAVSEAAEEEIRERLEKEIKAKLEVETKLKDEAKARKYAESNAELLKASVAEESANRLKADEESGREPRVGVESDDQSGPKSPYPDSLPYLSSHSETSWDEMEVVDSASEATEDEMELVSDEEHEVIEEEIVMVEEIVDDDADFDDLQASRVAQEESVEGDGSSSPSLSVESTKPLSDARYRQQLIDAEFDRIIRDAEEHELEEKIEPEAVEALRIASNILPYRKKYYNSSEDRFIFYPSIRRLLIEYTLIEKAEQYYYEEDDEFPIEYSAALRAIACESTGDDDSEDEEMEQFGVDILFQGAAMAELVSPSEDAEFEIVADVSDVSDDEEMAEDSPSPLSRQEEEANNSEPPRPSRPSPVFKKIKAWKNPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPE5</accession>
    <name>A0AAD2CPE5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001063">
        <property type="protein sequence ID" value="CAJ1941700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPE5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="243" mass="27099" checksum="102E089F95C4EFE4" modified="2024-05-29" version="1" fragment="single">MDETITYNQYTIDTAILAPTTESPEIKQAILQQSVNSIKQTKTTMEHKVDFLMKRYTSVCPDVHSQVNAATSELFDVTSDVYKFSSLHIINNMGQAIATGPGPGLPAPFRAAATYFRIELQLVPRLCSLRTDIGIDPTKFPPSSNRAVYVPVPRVQNQMDVYITRQMVMGQAHHKEIIAAMAALGEEFLMRAATRDGEPNKEAYEKWSKQQIAKTQFQALEQALTATYVGLQQGMETPNQQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPI2</accession>
    <name>A0AAD2CPI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000223">
        <property type="protein sequence ID" value="CAJ1932290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1932290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="95" mass="11357" checksum="C2715C330F0E8BC4" modified="2024-05-29" version="1">MKKSANAEYDFLDFWEANQKFFAMKQGTTENLMHFKERFLRQAEVLQDLYGIFWFQNFVLLAPILLRKISSRTISLKQFLQQDSCATVIEREQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQW8</accession>
    <name>A0AAD2CQW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1941205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="630" mass="70752" checksum="7FB4BD6EEBEBD3E5" modified="2024-05-29" version="1">MVQTTLTQKFRRVNPEKGDDDSNIDQDDADAEELDESAVHLTQVELQSFTQKWDIFTQYYDEDNEVPDDQPDRIDFSQAQLTQPAADEEENAVEEEEVHHQRGPKRTRHNEFHLASLIQRVPVDTENKWHLDVDGTWKMFKVGERFSIGAQVDTRHPEIVYTIQDFFHDPKVGKMAMCHVAILAQATFIGKENPVFSVRDFEKKFGSRYVSCRYSQTKPLRKLHRIIDTTGIVAPNVYFDPPTRQTKRPGWTNAFSFNQSFGTNETCLIAESPNALDGFAGGGGVSHALELAGFKVTHAIDNEPIAVATLKLNHIPEDTRVVDQDINSFIDDALEAHANPNDPYNCDGTVHVHLSPPCQGFSRMNTTESEASKEKNNQLSLTFPRLVIGIKSTTGSFENVTGMLDDDRVHYVQRIAYEFIMNDDQVRVGILDSSEYGDPQKRQRVVMFVSKKGWKLPDLPEPTHGPARPLEPLQTPKDAIGDLEQVIPRNKPGILALPPRKSGSDGSERIIEVDHHVIMKSDDDRDCYSKTDSLVANKPANTVLCGHAIKQYKLNRACTNLEGARLQSFPDDYKFAGNPKQVQKQIGNAVPICLGTAIAKAVYSVYDVDPYLFDSPPDDALELPKKDVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR04</accession>
    <name>A0AAD2CR04_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR04"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="339" mass="37683" checksum="F1A541EEB701C3C9" modified="2024-05-29" version="1">MTSLSFMINIPSPGEKGYKQRAPINSMLTHRTIASNAAAVGANEEYIFPSASDLASVRSDDIAMTAPHAVPPPLSSSKEDMSLSARRLRSLRRQRLARDNRGESKEEVTYDYAFPAGSYILSMGSEGYDNRGGLDDDNNNASTMRYHDDSGSHATMEYSMMSGNMLHSKGQIRERQYEESKSNAEDDSVQVYYSRLEAAIQNFSTSIMESMSDGWCGRANGCDEDSSIIVDETSSNRNHPSNQEQRRQQQHPNDANTIEQPLDPFDIIQDPQVAAILKKTRNRHDAYGYVHASRPRDSRGDAGSYTSTDTHLRALEIVARNKTNNQNRNSKPRSTAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR91</accession>
    <name>A0AAD2CR91_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-carotene isomerase D27-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038938">
        <property type="entry name" value="D27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025114">
        <property type="entry name" value="D27-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33591">
        <property type="entry name" value="BETA-CAROTENE ISOMERASE D27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33591:SF2">
        <property type="entry name" value="BETA-CAROTENE ISOMERASE D27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13225">
        <property type="entry name" value="D27-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042036148" description="Beta-carotene isomerase D27-like C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-carotene isomerase D27-like C-terminal" evidence="2">
        <location>
            <begin position="153"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="285" mass="31921" checksum="329632CD5557281D" modified="2024-05-29" version="1">MNLCCIILLGTICISSSFFTSKYERRRSAAAAIYAQTVKGPDADTKPDYEQIHGPLGKTLDRLFLTIFRTRMAEQVGIDSSLPKDDYQGLMELTGAMNARFSDRTEVQKTAQNILRSLFPSWLPRQYASLFSRPFPQFSARMNAWATRVAGTWLMGECELNDVEVDGKLYKDQGLLVKRCRFLEESGCASVCVNACKIPTQNFFIEDMGLPLTMVPDYETGECQFSFGRMPTVEEEMEAKATPCLSRCPTGGSLRRWHDGNRESVDLSPISLNETSSACQFMDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRF5</accession>
    <name>A0AAD2CRF5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="321" mass="36700" checksum="DAEA5EC21802AEAA" modified="2024-05-29" version="1">MQHERPGEVFDQVRRGEMQLKGARESKNGEVGKASGNDRASEAVLDRMQSGESKETIAEEIDDIQSVGSPLKRPRTSVNESLGALDNIWNIKAVNSKKGRLDVIHETRELLTNSVAELIQDGKKAHHKWARVQQELDLANEYISSKTHEIERLRALDAKNRENISKLLRTVTSTNEATQEQSQAKVSEARLRSDLLQMTKSRDEARQRLSKTEKRCKLLEKDLAGVKSKLAQELQAKKQMQHHQQAAESLKNAFHGGNQSNIDYYKRKVTELNTHVQGLTWILAERNREIELLQHQKDRFLTQNQQSSRRKEAKGTTRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSB2</accession>
    <name>A0AAD2CSB2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001280">
        <property type="protein sequence ID" value="CAJ1944946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSB2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="93" mass="10704" checksum="107D31CBB2FFB4AC" modified="2024-05-29" version="1">MKKSADAEYDFLDFWEANQKFFGMKQGTTENLMHFKERFLRQAEILQDLYGVAWFQDFAVKTKAYAAIASNDTAAQNKFKDDIFAAILATGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTS0</accession>
    <name>A0AAD2CTS0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="170" mass="18209" checksum="D014BB6C1CDF1BC1" modified="2024-05-29" version="1">MSTTLVDEGDIDAKWTFNKGGRVSGQFSSAWGGVLVASGDNDEDDDDFALQPISKLDPKQPESPVQKMTKVQLEFVSPKLREIAEDKDSILNSAAGTVSTCRDSVSSHASDIASPNVPKSPAAQDELSPMERARLALSKKELTKSARSQQKASLKKSIDTLAFTGSPLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTX1</accession>
    <name>A0AAD2CTX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS8253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="374"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1943052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="595" mass="65360" checksum="3665D325EC666E60" modified="2024-05-29" version="1">MPNTNRPPTGQSIQDLMAQRYPQPNRARNPHFPPQHPPAYQQPPQQMNMPNQQYQPTQGVSYTNPPVNPQVPNRLSPYGSPPQASHPPPAGGMSGPPTTFPNPTPKPAQSKASTTKKIDKNIATGPSGFPYNTDEQNKLLSYCEWKDKVLWASRMILGGNSVNGFLRATAAAQRIKKQRARQSAQARKTAAAAASTGGNAEAAADADKKAKPVFDQVEEEKLKKDIMNPRTAKKIKSELEAGMEYCTSLHNVLRSVLYEVDPSMSQYFPAPLDKPALVPTLPTPQQPTVPHDSSIPWALNSKTAPKQRPAPAAPSASSAASSAQNVGSSTLRRSRRKKLPPSKEPPVNLPEFDSFGKRVCAKKEHSIRVFEVLRFRSLKAGDFVAARLSSRDLWILAKVLKDYSGFTMAPVEFVKLSGARRDAVFKEKVMVRDVEEKEDGGSTLVSRNLVLPLPRTYSEAAEWGQRCKKGSRVYAMYPQTTSLYPATVIDSTTYCRNDDDIIVVEFDGEEQDPTGKVPQYHIPARFVTLIPREFPASQESSSKQNKVKTQAKNESDPFTSSGFGGLDALGDIDSIELDLDAPLEGGEEGMDFPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUP2</accession>
    <name>A0AAD2CUP2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="361"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="451" mass="51992" checksum="782C40DBB1424FB7" modified="2024-05-29" version="1">MTVENPFGIVEPTPMFQSSYAEIKDSGAAVDVLPANIPKEATDIDHVDSMIAQQMSSMTVQDREQAFMDVHGVSPIIEETPELVSSKLEEMESQIQKQHRREAYDMAESMNPDYVRDPEFRLMFLRSDVFNAYNAALRLIRHFEVKRDLFGVDKLTQEITQDDLDQESMDCLYMGHSQQLTTPDRSNRIISLWVSSEDHEKYSVTALLRRQFYQNMHLLRTNKHAQKDGVVAFLYLLGRDSGNPFPYDTGLELPRLANAMPMRLVAFHMAHDNKWLAPLIAFIKYSFNLITRIRIRTHYGSHNECMASMQGHGVPPEILPLEEGGIVTNKDSYREYLRGVRRQERIQFPRRQQIYVPCSYDVLFGKGSSVQTYEGNKRMRRIVTDRQKAYEKAEKGRKVDVAQEVVDMVHESSGMFLKQADDGGEYWVAVDNESARKKVSAAFRTLRIRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWL0</accession>
    <name>A0AAD2CWL0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001638">
        <property type="protein sequence ID" value="CAJ1946179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWL0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="321" mass="35744" checksum="463338106701F4D3" modified="2024-05-29" version="1" fragment="single">MGAATPTKTVLMGAATPTKTALMGAATPTKTALMGAATPTKTALMGAATPTKTVAFNKKKKRKKKKTLTNDTMYDIDIGTMAAIPPLFTVHDNMVICGINDATLFQGRTQAERIAYEIFSDDFNITMDVSIDKLNDELKTLAGMTTAQGQIRLMPGIKKNIRAFVQWCRDEFRMGRDPATVQFPVIDAAHLLRRMKTHEQYVYGSKLMSQQALPQDFTNDVTWEDWHPTFVNYLRTMPGRDGVPLQYVVRTNEAPVPTYHEDFLEMYIQMAPLHGEAFTMDNAKVLVLLRKFIVGNTQAEATLRAINVEGKGRDAFIALRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CX81</accession>
    <name>A0AAD2CX81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001271">
        <property type="protein sequence ID" value="CAJ1944914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CX81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26257" checksum="4A85C72A62E194AF" modified="2024-05-29" version="1">MTDCNPNRIPATGPLGKDPDGEPMNEEWNYRSIVGMLMYLSTKTRPDITFAVSQVARFSSDPKQSHATAVKTILRYLKRTRTKGMIIKPTGKLNLDLFVDADFCGLYNTEPHTDPNSAEYNALSSALKTLIPLKRLLIEATDHVELDNGIRATIRASAIEDNQGPYFLATNQRITSRTRWYLNKWHWFWQHVTKDGVGPETVAIHELDTSLQDADYFTKAQSCEPFESNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDW0</accession>
    <name>A0AAD2FDW0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS2260</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; bile acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000125">
        <property type="protein sequence ID" value="CAJ1931147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDW0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024204">
        <property type="entry name" value="Cyt_P450_CYP7A1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF4">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000047">
        <property type="entry name" value="Cytochrome_CYPVIIA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000047-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000047-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1931147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57471" checksum="643C3C86F73BE4B9" modified="2024-05-29" version="1">MTASLLQTLATSSIKPNTAHVTLLSLAATAVTIYTVSSVLAFQKRRKLPDGVRLPPHLTSYVPYIGVGLQFVSRLIVDFIYDTAKKLDAPVFTATVNGTTCVFIEDPDLVFTPFKDSIQEIDSSSLRRQALVTLCGIDPVTAEEITNDEEVQKVVFADFHKLKADQLYKNMEAVQRVIGGRLEAMGLSETDGEWKSVRMFEFVREFIFFASVGPVISNGLMTQDQIIETYAKFEEGVPSLYAEAPSFITKENTDARERLVQMLMTPKVDEGLSEFMKARKPIYGHIPEVLARMNVGLIVATVSNSVPAVFWVLCQLLKTPKAFEACAKEVKHVADKKANKEDPFTLEELDKMPLLESCFKECLRMYQSAFIVRSVTGDFVLNPKESSGPKYLIEKGTRIMAYSATAHMHPSIFENPETFQYDRFLDPTKKALNGKRLLSYFRPFGGGMHLCPGRKFISYESRVFLAMLLLKLDMKLEDPSEPIPTIALHHQGFSVAHPNQDPKLLVKVKESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE25</accession>
    <name>A0AAD2FE25_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS2481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000169">
        <property type="protein sequence ID" value="CAJ1931646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE25"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="748"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="748"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="867"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="899"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="960"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="977"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1931646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="995" mass="105001" checksum="F15DBD98A7BB76C3" modified="2024-05-29" version="1">MAEHSPFYKSLDEMIAEDEQKKNAQSQQQQRQQQQQQQQQQQQTKGDPSNIPDQVVWGNHQSHDDGVSLISMPTALQHSYFNANQTTHDMRTYGQPDHHDPYYYGQIQQPQQPQQPQQQQQQQTGESSQAIEVKLKGGTTDDNGTISGPLSPRRDEIISTTTPAVAAAAPSKGHVRHPSNNYFDDGDTAPGFPNRSMRSLEPGQGGQQGGQPPNLLGPPQPQQPQQPQQQASDILEPYYPPEPPEVPQVSGVGGSAPPRPYSHHTYVRDPAQYHSNDNDVDAPFGPIDDLRIPLGLSSAPSSPIDGQQSPQSGMGLNLQDNDPNNNNPDPTPSWRKWLIIIIAILAVGAIAFAVVLLVQGGDGDDTKSNNNNNGIDFVPPNRTPAPTNTPPSVPPSTSPTEEIVYDPPSVQDCEAILSGRAVPGQVNMIERLYEIPFDIVINEGTELIGFLNQFMEGIRTLVVPALTQCDTVLPAGLRQRRQRRHLRDISNVVANAVATGEYSDEPCSRNNAALFCQRIVVNFALYLKGDERNLDIAILIRNAIAGTDGSSSGDSSLLERFGLLGKANSVQATEVVNLNPTESPSSSPTNLPSVSPSASPSKIPTRSPSNSPTLFPTTSMPSKTPSFSPTKMPSSQPSCSETASWLDTEIDSTPLRSGGLVTYSLNCADATDGIAVLVWDGIDKCTTQCLGYLDQADSDGTCSTSTQFIVSFNVPDGQDVTTSSFLIGTMDPITAGSFSLTCPGSILASESPSSNPSAGPTQLPSIQPSFAPSQVPSIGPSMEPSMIPSMRPSSVPSMKPSRVPTNPPSESPSRNPSESPTDSPSRNPTSGPTLRPTPSPTISASKQPTANPSPAPTVMASLTPSATPSNRPSSGPSSAPSKTSSGTPTTAPSVAPSKRPSQNPTGMPTNGPTKNPTFGPTMAPSHNPTSGPTKNPTSGPTLAPVPGPTDAPITNAPTKAPTSGPTSNPTTSPPSKAPSASPSISNVPSVVSLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEF7</accession>
    <name>A0AAD2FEF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEF7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="447" mass="48661" checksum="59DB011712C7BB04" modified="2024-05-29" version="1">MMDNPYQVLGLPLDASESDIKKAYHKAALKYHPDRQTNKENEQDAGVRFAEISEAYETLTDPVKRYDWRQKHENGGSGTTSTKPARAPASPSRNAAPPSTTSSTSSTSYQYSNPVSNSSKRAEFMAKKQESESTRASFASPVSLRRKRQSYAAAPPPSPMQSTPRASVRPSIRRPSSSSPSSSNSNSNWSNKQRMASPDSNSINMTGSVRSLNAGTLRAKNNSRVPQSAGATSQRRTVGRMSMQMPQPPLSAGAGTHKRRASVATPSQTRHVPQGPLPTVSTSRGLVLRQSVRLKPSAQPSPAPRGNLPAAPRGNMPAPPLSSPAVRRNSLDGSGRKKSHRDTSLDGSSRKVRREKTSSKKSTDMVVKRPKSQPPPRKSIFGINVGKKKVHNNANDDKSMKSNKSKKKKEEKDGKKKKKKPKSLSAPQQTLLTTTTTTTTKMKKKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFA3</accession>
    <name>A0AAD2FFA3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS5184</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFA3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="219"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1936423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="319" mass="35646" checksum="8F3A1FDA3398A05E" modified="2024-05-29" version="1">MASRDLTASFMQRRANARRRRGDRDSQSVPLTAGGSDHALMLLEEGSEGANGDASNGIEMSSLNKRPPSWVRDVDSVKEVLAEIKRQMGELQSMHASRVGSVFGKDLDHMEGRIEIMTREVTNRFRDAERTLKKVGTSTRNAGGEEAAIGANVQRSLAKQLQELSVSFRTSQRKYLAEVQAQKNGDMVGDSKFGISLDEGGGENSFFTSQQVQVVDDLQSAIQSRDEEISKIAQSIEELGTIFKELAVLVIDQGTILDRIDYNMEAVVEHTKTGITQLEKAEKQQKNARPMKCILSLILLIFILLLLLVLKHRRRHHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFB4</accession>
    <name>A0AAD2FFB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="335" mass="37458" checksum="8B45DEFD861557A0" modified="2024-05-29" version="1">MTDKLQGSDKTESSLEFGNPMTNENNPASSKHSTNDDESWDGCSNDEAPKLNRGRTVSFGGIPIPDETPSTKGPEDIPTTVVNPGLLLGMIFGCAKWSEERLRSTALGLVSSITVLVVRLLLDSEPTAYLIHSIVVFLDMALIHAFTNSIWLSVSGELVTIAMAFAFHMTKQTVWELLETTILAILCSFHLINSRNKYMDNAKELRHDLNTICHETSGLLSASVRLDDEDEGSVVENEDRRAALIRRQSSRRLQQIRSTMVNWDSDRSIEFDPADNDHVGDLEKPVYSKHGEKVKVWGEKFFEHFLDGSAGVMYTSFFGLILDEMIRLNDDINCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGE6</accession>
    <name>A0AAD2FGE6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000735">
        <property type="protein sequence ID" value="CAJ1938570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGE6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="18545" checksum="0423C1DB526B0052" modified="2024-05-29" version="1">MVVDWLLQQWAPKLQSKPRVRIACDGFSALLNTFGDHRVSPHQAQFDLVSSLREALARSKALWEPSHVYGHLDRATSFSSLSWWSKRNVEVDNWAVAYRHQLEASHQLIAPNARFFTELAALYIGGVKQSRLDPDYIQELVELPALRKRWHEKLTVTPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGJ0</accession>
    <name>A0AAD2FGJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000591">
        <property type="protein sequence ID" value="CAJ1937033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="274"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="846"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="936"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="851"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="936"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1937033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1067" mass="120243" checksum="9A6934155891C397" modified="2024-05-29" version="1">MTMESTPSKVATGSSSTSILCEIIGAQNLTVPTAPKEALHTFCTVQFNRKLVHTTRPEAGRNPIWTVTSKSLFLLPESKVETLSNPLLIEVYAVRNFAPNNSASSFFADRTDRIFLGSVEISRTSILSQCNGQRIELKIQKNRKDNVGTLAVRFRISQESDQQILNLLKSSKDGSQLKKEFLDQILHGQEKEQRSPSNNEKSKSKLLPIANLVTEKSDSSLAQNNFFSLVNNMFTASTVYDTKSYRELRRIKPYPNPKSPNETEFLSATDIKKQTYGPSHSWVEAGSGKLGRLYVEVLACHDLPNMDMGEAVGDYTDPFVCLVYEDTVATTDVIDDELSPHWLPWTQRAFSFGTMHPASILYLGVFDFDVGSDHDPIGRVAVNLSNLQHNTEYTLEYALYKSSNVTDRTANGSITLRLRMECYDEKAALMEVLAPRPRININVRMQKTFRVVRYTCFGEYDNEESFDLTVTRSYINEILCYKRKLYYAIRDSFFSLVFWRGQVDIAGDGTTKVPLYSFLFFVGACHLIENPHLVVPFTLLSISFIMMASHTQRIQHPSPWKRCQSIWHFVDILLGDLTKSPANAADPKSNLASGVSVKAFERHQEAEAYEKSLQDRVELDVLREQKRFELQQELENYGNENISTAVNNAGMLLPPDLQARLTRWQGIIGRICTWIRCIRIVTLWEESILSFWITAAFFVSGVVSMILPWKFILLWSARITVWGFFGPHMKVIDTFFQLEEESQKVLIRNIDRLFQEARLRREEAVKVQAIKVLAFGKYSVLVPSYNVARHFDQPLAPSFAKQSPESHSLHVAQMIPGQQLYGTMIPRPETEAALYSEAEQRILKHREASSLIPNTPSSDITPTTEPDSSEDGTNAQERGASRRPTLLHQEAIEVVAVVSDGEDEALATISNEEDNLSAAALRIRTVETNVTSFASSSYYDSSSYDNSTGSSEDEDDQNDDRKGIEIVPKASTYAEDEGLEIVATGRLQSMEPDELLLLRSKSLDSIIFHRRESQDIARDGSEEGEGLDASEMRRVSSEVGYSTSASISASKRRRPTLTVEVDENPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIE7</accession>
    <name>A0AAD2FIE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS3661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="140"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1934248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="262" mass="29380" checksum="7B2052B0D7C41C5F" modified="2024-05-29" version="1">MRGITRPTKAKIANPSTQEEEEVAKTDPVSPTFQKVQTETSAERNSSALVVGNESPGDRPNVQLFTGMKEDVAARIPLYCDDWKRPKNLFTTEGSLAVYEALLIGRIIGEVYALLRGHFLLVKSDKPAVKSGQPHTPHYRMRTVFAVYNMAIAIIVMSVLSFLPGVAQDTDLLHGIKRVETRCIPWDWRPTTETGTEARPWVTYPLDGIEVKGIFGALFPAFMLYLLFFIDHSILTQAPTYKLRKPPANHWDSFVLGLTIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJI8</accession>
    <name>A0AAD2FJI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Plant heme peroxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS8882</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041936478" description="Plant heme peroxidase family profile domain-containing protein" evidence="11">
        <location>
            <begin position="17"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="12">
        <location>
            <begin position="91"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1944427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="379" mass="41045" checksum="04B259CB5F525E44" modified="2024-05-29" version="1">MQFSLWHASLSALALSRSSFLQQSSSALLSLASPPPLHILEPPPPPPTTTTPTTTTTATATAAPRTGRVIIARATSNDGDSQIASVAKAFRNDIQTIVKNDPSLAGPLIRLAFHDAATWESSRGSTSSSSSNPYFWLRQQPSGGPNGSIQYELGRSENRGLSKPLQFVQNITHGYAASLSLADAIALAGASAVEAIGGPTIAIRMGRIDATQADPEFLRTPLKASTRRSIVTKTLPEAGLDSDGLRLYFGQLGFSEKEFVALCGCHGLGRHVSLLGMPKDCLRNLTRTCLEEAPVLLPFVTKSVDTFDNSYFQFLLKWNSNDIKLGDVAFIPTDVDLVVDTGLKRWVDYFAQDQNAYFNAYGQAYQKLVDRTATTQERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLF2</accession>
    <name>A0AAD2FLF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000924">
        <property type="protein sequence ID" value="CAJ1940639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="HMGB"/>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLF6</accession>
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            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
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        <name evidence="3" type="ORF">CYCCA115_LOCUS7170</name>
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        <name type="scientific">Cylindrotheca closterium</name>
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        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
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            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
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        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <position position="379"/>
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    <evidence type="ECO:0008006" key="5">
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            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="424" mass="47909" checksum="D0071052B1BB2A21" modified="2024-05-29" version="1">MSASVEQAIEQVAEAIARVENEIEEINEILKNPTISDVDKAYYRQKESQLRQEKSQLRQEKADIRQKELLLIERTPMPSIPENQSVNTPFLEDMQKDITVIKESVSKPDRATPQKTPASFGAEELSRLEGLGNVHNPDEKGIGDAVLTTEQSGSLLQLETEHQVVAFLTPFLTAVFQCNGSSNRVLVNSEEYKWLKTSGDEKSTYNQKPDMFICHKSLYQKRDPFAATGDSKLHQMRRSTDIFGQLSHWNLRRFLCVVLEAKKDISNSAFGQTINYAAHLSFEESGPITVRLVLFDRESFWLVETVKGRASSVRKCRWVDGGSKSRLEKFMLQDPLIKVLDKACFELGLVPEENGYLGSGAFGLVFKVCNQNGVAFALKIVPDVDDNVAELQKQMSITNEAKRKCPHLIVGAEEDSFRKFESYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLT2</accession>
    <name>A0AAD2FLT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8110</name>
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        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
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            <taxon>Ochrophyta</taxon>
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            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="80"/>
            <end position="165"/>
        </location>
    </feature>
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            <begin position="636"/>
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            <begin position="1"/>
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            <begin position="248"/>
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            <begin position="318"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF20710"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAJ1942764.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="662" mass="72906" checksum="8EBB37FDEDD86502" modified="2024-05-29" version="1">MSDDKSTKESETTEVKTEGVTASEPKKESEASVKGDEPMTEVKKEEDAKTAEEDRKKKEELKKKYANWPLKGIKDPHENDVMYGRGGGTNHHSGNKQYRKMVEDRKLEYVNSKRLDKPLVALEIIRIWRGQVPPGRFLKLDEKTGLWNDVGDKKAREKTSQALREKAPLIRKQQEDEKGEDEKSPKAADAKVTRFAAGTKTESSKAEKPVLARDHSLGREYLQDGEAVSVEGFSWRDPFLADSGKRTPSFGSAASPMAAPAAPGAYPPAGRHSSSGSLGIAPPHHGGPPPPPDYYGRVGSNQLREYSTGRIESWGSFPYPPPPPPPAVHGLTHQRSGSWTYNQTPPPAMPGHQRSGSWGGREHSLAFNPLIGASVALPADQRAFEPRPGPPQQYWATGQYRSPPRQLSPANSTPSPKPTYNVNMDIARTWSGGAEGNPRPGWVDQQNKPMAYSQPVPVPGAGDISPMRNNAGYMPKPQMVKRDTSHQAESSETKHQVKRAALNRDNSMASNRLKAQYMPEYYNGQFNSDHEVKKLSDNLEQSQLSPKRSEPPVAPKPESLKDSNRLTTLDINELMAKPEPLSTRTTTMEALGIDLENEPMFDSPIEGGSNIPRPNVMTTDNRLTTTEIYDLVNADPADLVKGSDGPPPLNQESVADNWLTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMP6</accession>
    <name>A0AAD2FMP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS10427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238">
        <property type="entry name" value="MEMBRANE BOUND PREDICTED REDOX MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="THYLAKOID MEMBRANE PROTEIN TERC, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1946286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="364" mass="39042" checksum="1628306897AA27E8" modified="2024-05-29" version="1">MKSSVRIIAIMSACGIVNGFVGPTIPITPFLVKQGSSLSTRPHTSYQQSRHSQLHVLSEKDLADSPSLSSTDPNGAGSITMSSEDKIFSTAIRRTLACVAAAATFGTGLGFAFGSTTSEEFFAGYLLELSLSVDNLLVFLLLFEYFQVPMKYQNRVLNYGIIGAVMMRAIMIGAGAVAIHQFHAVLLVFAGILLFSSGKVLLGSDDDEEEDLADNAIIKLANNFIKSTPSFDGNKFFTVQDGVRLATPMLLCTIAVELSDVVFAVDSIPAVYGVTENPLVVFSSNMFAILGLRSLYTILSKAAEELEYLETSVAIILGFIGSKMIGEYFGFEVPTEVSLGVVFSLLAGGIGLSLWEQGKEEKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNB4</accession>
    <name>A0AAD2FNB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS10866</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040001715">
        <property type="protein sequence ID" value="CAJ1946847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="14">
        <location>
            <begin position="121"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="14">
        <location>
            <begin position="295"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1946847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="468" mass="52541" checksum="B132A5AB4AAC2E4D" modified="2024-05-29" version="1">MTSEIENEVPLVASILLACKAFIIFLSESPLMSVLVELIEKMLLLVGATDSFVPSALDTSRSIVIISLTLLSYYLFFGKRHSRKRHRLATELQVAREKLHYLQEQVLRDESGSTNEVRIFLDGAFDMMHYGHMNAFRLAKSLGTHLIVGVNSDKSITSCKGKPLMNDDERHTMVSACKFVNEVVPDCPYIMNKEYLDYVIDKYSIDYVVHGDDPCFVDGKDVYAAAKAAGKFRTIPRTEGVSTTDIVGRMLLLTKEHHLHGGLGSQSKFLTTSRMLKLFSADVQPPTKDMRVIYIDGAWDLFHPGHVAILKAAKSRGDYLIVGIHGDGVVNRQMGANFPLLNLHERVLSVLGCRFVDDVLIDAPYTVTHEMIASLNISEVVQGTVYDDIGSDRNDDSRYKDANDAGLLSVLQSPCDFRLENIVHRIQDNQETFQARFKRKTEAENDHYKDKYGHNSANSTSGKIDKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNG3</accession>
    <name>A0AAD2FNG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNG3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="127" mass="15115" checksum="853393CEED9EAFE3" modified="2024-05-29" version="1">MYEDDEFLAELSLFLESPIFQSPPEVFLAPAIHQIVRGRSGVARHHIGNFDFLHRFLRAYDERYRSAHNGRKRVLAREILDRLRDAGYQFIEYSKVHQGYIEINNDRRLVNSIMHSMRDAIKSRIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNV0</accession>
    <name>A0AAD2FNV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1125" mass="126438" checksum="FA6922AF95C3BAFB" modified="2024-05-29" version="1">MQIPMMKEYTPPPKPPPPVQVDQEISIPSDHHAGAPSVFGDEDALLSVTSEAYEVSTKHTDRSGSNRTRYSQGSYYTMDSKELKASELRPKSKEDPAMILGDPNKDSHSGSRYGQDKPLNIASNRLVARDKEIATLKACFQRLMSNDDDDEEEAKQQIKNKELVLISGQSGVGKTSVVQTLEDDDIAKSGICITGKFTMTSSNRPYLGISDALNKAFQTVIGQSKNESVSKAIQDELNQEVPLLRALVPCLREILGNTESKAPADLDYEELENGLERLKYAFRFLIRVLCQEFTPFLLVLDDLQWADIQSLQVLDSLISDINNENKLMIVGTYRSDEVDENSLLYNKIMALHEKEEDFQFRITTIKLNPFSVDDIDRLIQTAISSTEESSQIKDLSELCLKRTHGNPFFVIEFLKMLHTERLLVYDSSKEQWDWTLSTIEDSTMSTANVVVLLHERMAKMPKQVQIILQYAAYLGSSFREATLELIWSTYGTMRALGNKEPLSNLLAIIIRESFFEKIRGGYRWVHDKVQEAALYFTGDVRPTVQLDIGTTLYYCLKAEQLEDDIFNVVDLINNGNAKKRPEFANVNLRAAEKARGISAFQAAAKYASHGMELLTDTRWSDNRSLTLKLYTMAVEMEMILGHTDVAEKYREEILKNGNYTVTETLPLKLSKAQSLAVVALHFDEAVGYCLSVLKELDCRLIVARALVPVQMPIKLLSTMSKVKKLDVDFFKGMGTMSDPKLRAIASITNYVKYAAFVGGDLFLSLICICKLTEMTLKHGLNEFSGITVASLGMTALLVQQDCELADKIMQMALSIQEQLGKTRATEVLYTSYAFGWPWLKPLRDSLDPMRRAYTVGVQTGEMVHAMWGLMANVIMIPYALGTPIETIVAECAGVVAQADEAKQMGQALDAKVFWQMLLNLNLSTKDGGAKLEGKMYSKANDNNDFTIHLSTVHLCEGELLIFHGEYEAAAERAISKGDLFAKQSPLMFFNMSETFNRGVALYVMAQKTNKRVYKKEAKSIRKQVDKWAKSGNPNVGHFSLLLQAEQEALEKKHDAADESYRKAITAATKGNYLQYMALFHERYSDFLLNVQSSKEDSAHHLNEAARYFEEWGATTRAQSLRDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPS8</accession>
    <name>A0AAD2FPS8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="140"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="325" mass="36833" checksum="B0796C43C718C244" modified="2024-05-29" version="1">MTCDEDYLKSLQAAVDSVEYQMTNLEQGQIQEILKALSHEEQQALADQYMTLRHLRAEKGDVQKAIVALQRTLKWRNEFQVQDLKHCLHKHKPPPNVVGVEEEAEAEAEADEAKEEKKDDGDNANSNNNKSKASSLDELASVVRKENETGKLYIRGYDKDGRALLYMRPGKENTNDEEGNIRHLVYHMEKSIACSAKNGQSKICIVIDYDGFSLRHAPPMSTSKYTLDVLQKHYPERLHRAYICNPPWIFKGFWKVISPFVDPVTKQKLQFCSSASDFEKVVHDMGGLEKANQHLEECAGGTVKPSTDFDTNAYLSLPLDMSLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ87</accession>
    <name>A0AAD2FQ87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="347" mass="36634" checksum="78347D6038089EE0" modified="2024-05-29" version="1">MIIEIEDSEASRASDTVEDLPTYDNEDPRAAFSGLSSDRILALTATGLSQGSSMMASESTLPSIDHEKDKEHISKLDDNSGSMQVTKLNPPQRPSTEPIQDQQQNGPKVSLSAAQILALSGDMAASRSAKKSNPRNSKVAVPNSSDTFATPKPVYPQPNDDAVARNDAQEDRGPTNASSMRSPGAYQVEGTQSTLSQNLGPAPPSPTLPSGRHSKGEQSVVMASAIDKEALKEELRQELLAEQTAAHVVMAVPAGTDDENRDSGDDEKHQTRSPRTSFRTNRRWWILLLMVFLLVGGAVAVAIIVTNNNSSSTSIATDKDDEKPPRNSGSGGDGGGSGKGGGKDGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQA8</accession>
    <name>A0AAD2FQA8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="722" mass="79961" checksum="7C83E11D5BBF4C7F" modified="2024-05-29" version="1">MVSTSTKGIQRDMPPHGGINEPFKVSPNSSQDDTVPTERGRKLSKLNQLQSGLKSGLNQTGQGLKTGLNQTGQGLKNKLQAGSNMLFNLGEKDHDALKDDDSEGDAAKSYSNDQVVWYKSKGKKNKKATILEIDVGPDGQAFYTIKLNDCGREKQTDDAHLEPLGPNDAAEDDSRSRFKTGQVVFHKPGDGAPIYLVQISRVYHDGDGQPLYEISMQGSNLKKSSIRESDLLELHEVPATGTNAPAQSPSNHSRKSSRKSRSPKRGIKKTLSSEGLGKLKRGIKKASSMDGLDQMRKAVRGAGHAAGHAKATLVKAAHLPLSRHHSGLSSKDGSEEMSRQSSFRSQHSTEQRTRNPRVKKSRSMEGMREMMHTGKQHPSDGHLDGVRVRRPGVKKTNSMEGLVRTSKHGPLRKAPAPSQSMMSMNSQHSQHSGHRSVRSQRPQPRTQAEKNKLDRERGVQRSKSLEGMHPRNLRRPTSRERLGHPPNRGVEQNNSWHKEPGDRRPPARTASGDRRPPARTASGDRRPPARTASDDRARGGAPLQSATWNAAQRPIRRQQSADGKGIRRPVPPPPPKASTPPIRAVKKPAYDSDSEESSISSVSWQEPKPQSFSRTKVPPKRETPKPTEITVDMDDASAVSSSDSSWESFRERPGQRKAYDMERKRREQVVKPKLVTHDTEIIGFDCITGVEVRVQNVYSSDEDSQSSEEYEFEPEELFNWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQR6</accession>
    <name>A0AAD2FQR6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="645" mass="71659" checksum="6F8751D6AAC4BDDC" modified="2024-05-29" version="1">MFGKRWTSDTTVRLYTISWDLCNETIVEPDYLDIEPDVGNNIDQKLYGVALYFDPFETTGNLECRHSTMAQVAEKKYPTAQYLLIANTDLVPITKYDEELDSTLALATVTLDDGDAIKNRFGDETVSSIATGSILVTVDATSRFILDTSITLEHIERGATTIITMTQISAFLSFIGSVYVLYTLVGNKQRRSKSMRVPFNRLLLAISIADLMSSLAMMVAGWATPTAPPGNYEGYYSIERWEVKFPRAVGNDAGFQSVMVHSFRFKFYFLVLVLALSTSSSSSAFQHQHSKLQLQPVHQSRRLVNELVSPEASSHKVQHLNTGSSSTRNRASSLLSNVNDTEGATTESESEVERMLFGWNRLVSGEAWGEPSSMQKLWASLEDIVGVWGHVPLIIASFQTAMTGKCNELEYAICVGAVLLTSLAHGKMTYDTPRDWRAPRLAEYRTVYEFSALYLIPFGWLTARIQPHFPMQLEVLDPAMSLLFSAITIYGVAYALYGKGVLEEANSDQNLMDTIDESSRILPSSPAYQKQAQLYLTGNVVINGLACLFIPFAWTLTIRGTEWWERVQMLHPNQQAFLGLSLLVATIGDVSGNLLVRLKQLGGVTASESTVVIGILSNFLLLLFPELVFNGIYSSGVSEIGFYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR71</accession>
    <name>A0AAD2FR71_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="617" mass="69817" checksum="FD49C754251A6203" modified="2024-05-29" version="1">MSAPSTNNNINNNSSIGNGKSFQRSVFIFVLGCFFGMQVLNFQVSHDGSLAVQHESHFSHSDNHHDAPALKTIGAENSDDASATATTSGTTNTITGSIPKDELKSLIRSELLELLQETKAELVSSTNTAATQTMVRRRQEITTNDNNVDEAKDDDDAVETAPKANPETAPKAAPAEPVPPAPATDDDSPDTTTTIAATATTATSTVINHGTIPKIPEPLVQPFTYTEEDRARNLQWKQLGRDWRLDDPEEKKVWDQLAAEQRTKWSDANGAPPQTYDKVALVSKVHSSSPFIGSVVQNMCLMKAAYNYDRNYPWIIFSTLPWKKKALERAKRWAYPANFTVVIDSEPLADVLDKMPKEEREQLESRCECCHKTNCCKDSSKLHWDWWCHEHGAGHATLSYLWQAEFRATHLWNHPALKDYKHMIWIDNDALPTKPWPRDPLTTMVDNDLVVMYDNFPQGSCGNSMLIEKMKMAYDNRAVCKLELTADGHFNSIPCKEDQNKLTRFGLIHGMFHITDLDVYRDPVNLEMNRLLTQHKGYKFSRQWDDQIAVTVVPAMVAPERAWDMRRNGFNMSMAHNGNLDGKEKNSRWSYTIWWKYFNHTWPLASRMCSDVMTFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR80</accession>
    <name>A0AAD2FR80_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001761">
        <property type="protein sequence ID" value="CAJ1950310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR80"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="236" mass="26858" checksum="DDABC5C47D1E2E2D" modified="2024-05-29" version="1">MAVNAVVEQNNQTLAFIQQGDFVNAIESSSHALRCCRLLIGGEAEMLLNECLDHCMLLRSPVNANPPPMPSGDDPVFIYRQGITIPLRTSFVDLTCVTPILIFNAALAHQLLAEQQQALQPQQQRQQQRQQQRQDREQDEEDRDDLIYMLQMKARQLYRLAHSTVDTEVNVLFHFVVVNNTAVIDRRVGNPAVSNASFYYLMARFLILQHQGMNERIRHLEGFWVNLPTSPSAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRT0</accession>
    <name>A0AAD2FRT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS12765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="164"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1950804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="32050" checksum="03178C41B1F44318" modified="2024-05-29" version="1">MKLPNPVSMATAACSAYQARISSLAASITPRVLVSTSGSGNYGESGKAAFYTIDELPMALIKEEKPFKEGELQRIDIDLGPDRQAFIIDNVLTPEESDALAACAEAILNANGHSRVAPGIRTPPGMRINEAAHWYPPHGSSFLPTIYRRIEHLVPKSLDGGLSLYNKLSEKVAHFKYNKGDQFNRHIDGLFPGQGANPKGDGVDEWTGVVSGFSLLFYLNDADDGLEGGETRLWSRDGSIYKDVTPRKGRVLAFRRGSHDAVLHAGLEVTGEVPKYMALVNLAYGQHAGTRPLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSJ5</accession>
    <name>A0AAD2FSJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042027711" evidence="2">
        <location>
            <begin position="20"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="556" mass="61716" checksum="D3B44BE079EE2385" modified="2024-05-29" version="1">MSLLRILLTAVWLSHAVFGFILAPTTRTNIHSLSSFISRHRDEFPSSPVSTSLTLALEGESHTSLVSENGSVLDQVLHNPTFWSFNVMLVIVFLLYSWESFVEYAKEECPPAIVPVIEKILGEMGGLGFIGLLLSALLNQAAFGEVVGNISERFLGEPSTLLESFEFLHEVFFQAAIAFFATSAFIIVRVLMSFKAILELSSEQSENFGGSDAASQELSCTVARILNAPTLEKATLIRNCDEQEGLECEVDLEDGFVRKLAVQQVNPLWRELTLTPRARASEILVLRERLKKEFNLDEDFEIRKYLEQGFATCNLDLVEISPLSWVPLIPLIALANSVDLSHDVVNPAAGNSVETSGFFLSTPLFFFPKLLIELLNIGWFAINFVKMTSIKNMLLPTVVRVEGEEGRGRLLPPAVEFDDQRKAFQANSSPFWISWIEKIYATPATNRLEELFGIAGGSGLSFYLNSIKFQTWLVVASLVVFTSNILPRDVYALTHLDSVQVGSPENLVPEVLVFGLFALINVTQIFVVPITVLNFCLISCVESFVDTEAQEDIPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTP7</accession>
    <name>A0AAD2FTP7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Oxygen-evolving enhancer protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS13186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PsbO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTP7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010207">
        <property type="term" value="P:photosystem II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042549">
        <property type="term" value="P:photosystem II stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2050.10">
        <property type="entry name" value="photosynthetic oxygen evolving center domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.30">
        <property type="entry name" value="Photosystem II, cytochrome c-550 precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_B-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002628">
        <property type="entry name" value="PsbO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34058">
        <property type="entry name" value="OXYGEN-EVOLVING ENHANCER PROTEIN 1-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01716">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="OMPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0793">Thylakoid</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041946868" description="Oxygen-evolving enhancer protein 1" evidence="7">
        <location>
            <begin position="17"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1951684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="32181" checksum="58BE92C8C2A9A423" modified="2024-05-29" version="1">MKIVAASLALVASASAFAPSSMDSRNTALQMSLKNDLANAGKVALAGAAALTVATAPAAALTKSEINSLTYLQVKGTGLANRCAEVVGEDTITPKSGQKLVDMCIEPKAWAVEEEIGKGGKTEKKFVNSKVMTRQTYTLEAIEGPLKVEGGNIVFTEKEGIDYAATTVQMPGGERVPFLFTVKDLVAKGNGGSFKPGFQMGGDFTTPSYRTGLFLDPKGRGGTTGYDMAVALPGLQSGEEGDDALFGENNKTFDVTNGRIELEVNKVNADESEIGGVFVATQLGDTDMGSKVPKKVLTKGIFYAKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU60</accession>
    <name>A0AAD2FU60_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001833">
        <property type="protein sequence ID" value="CAJ1953560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="490" mass="56497" checksum="287253BB6A98779A" modified="2024-05-29" version="1" fragment="single">YEPEDEDERDFNLRGQFDDIDDSKRNELLADADNDVNDMPELIVRFQGDDDYESDDDDSSDEGDEEKEPIVADLDHHKENVDRGTNDIESLVTDLEDLQEPPEEEIVFEPEMPQVAKVTRSGQTYAQAAMSGLNLSQVPKKAREWLSSRSGSSANKNKNRVATRRKHREREMKPLKDKLNSGIRTKEGSRSTKDSKAILEPQHNLCFQQIGNEMKADYEEHGAILIARCMMQIKAKFDTDEGLNFIQQYYINQGQKKFGDDGKDAVDKEFVKDMTASERKKAQSAMMLLTEKQFEKTIKGCLVYGGDGTREWLSREDTASPTALQEAITTTCVIDAHEGRDIMMMDVPNAFIQTYMPEAKEGEDRIYMKITGMMVQILIDMAPEYREYVVLENGKRVIYVRVLRAIYGMLQSSLLFYNQFQSDLEAKGFVFNPYDRLIWTHNRFHSPCPHFQLSIRVLYILHPLDLRHLEYFHFGGLHRSVFQFCLLGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUQ7</accession>
    <name>A0AAD2FUQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="244"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="50349" checksum="56B479B8D57887F5" modified="2024-05-29" version="1">MLQLNIFVKYRVLLIGLFVTRIFGAPRFGARWSPRRAIPPRTVVNSPRSTTMKNVRSRPRSPRSLCFDMQQTNTTQTPTRLQNALNVTGCGLRKWREKVARDLLFEKEKTAEPISNEEPRKRHPWYPSWMISGIRCFWKGVLHVLQNYGILWALESIGTEIVHTPVKLFLEHGAHRCPSAYRIFRNGLLSCFLSLNRLAIAFEETLLYLFPVLLCHRFLPRGERSKRYASRMGLYCYSLRSEFVELVDAVVAAPIYEEFVFRFLFRQIWMQVTHLRKLIEERFKSHTTDEEVTRRKWDDLDDLTESWILPSSVLFGVAHVDNWMPLDRKYFWDSILIFLRLVGRKDIHKYPMRRKHEHTLLCSLFQSQHCLVLSLICLAPVYQHLGMMGSIGSHAILNLINGCIPNHRYILAVLSVCAGFARTIRSSVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV19</accession>
    <name>A0AAD2FV19_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001840">
        <property type="protein sequence ID" value="CAJ1953788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="214" mass="24025" checksum="AAC2CAEC0D4584F0" modified="2024-05-29" version="1">MPGFEPDSGSEEDTAAMEEEKNKTEKKKGSFGMLCEATLLADFQEFVSKTLLPIILLQKASLATNKSRARHAQDNGESVNFEYDDDHKEELAELSIESEARNNPNGSFVMDLDVGSQYGANYLPNDITLPTINFEVDDPHVTGPNGENISLPHPINPFKFRPDPQDKPDLVETTVTILDDKRNIQQLSTPRATPFLFYLMDLPQRWPDKSVVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWK9</accession>
    <name>A0AAD2FWK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15413</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15415</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWK9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="432" mass="48997" checksum="E996C8D9D897A146" modified="2024-05-29" version="1">MEPTTQKIQIDERKFVSYSEVLTGGERTLPAGPGSKTMMNREQLEELVKHLSWKTRAELCEMERSLQGHLEGLRKRLEELESPRGGEGYKNPYFPFAEVEQDRQRHNAKTQTKLEVTAILARLGLIQFALHSDLEPLKNITRESLRFWITIDKSLKYTEIPEAIYRLSVALERWGLTKNKHFQPLLANSEFKRLFGEDGLITDRAKLPKSVKDCIVYLEYLVGRDIPELRNAIPLAQELAAMHGRLARKETTEEDLEHQDALKQDGNKIKEIKTVLKGQYRQAFQQAVEKKHAELQGILDASFVVYQAEWAQKNELQGRLRETVDKMKANDDEMKAMDAQMKAMDAQMKVMDAQMKAKDAQMKAKDAQMKAKDTLIVDLQAACPNSPAPFAFPVGDGNGDGLVAEVPANINALKRAPAPQDDPAGQKRHRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXY2</accession>
    <name>A0AAD2FXY2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS16361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXY2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="54"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1956715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="530" mass="56309" checksum="A58AEC7E04761539" modified="2024-05-29" version="1">MIGSRNPNKVMKPNGNEQQQQQDNTATETRMHHSTLRRTAEWMGYPRIAPQPRIVNGIKAPDPDRYPYFVALVDDRDRIVCGGSLIASNVVLSAAHCGLTNLKFAIVGKYHGQIDVQHNEAERIPIVDTYSNPRFTLSNRSHDQLLVLLESPASATRPVVRLNLLQGGGDAALPVLTDRVTVLGLGQTYSSTQQTQDPPKVLQQVTMGVVSNRQCQEMYDEYEFFVPKISNDMICLLESAKGQCYGDSGSPYILLGETPEDDVQIGTVAWGIDCAREEYPAVGIRTFLEDDSFLSDTVCSIAVNPPSYFGCPTLAPQPAILSPTISPSAALTSDPTVSPSKAPTIAPTVMASDFPTRFPSSSPTIAPTVMASDMPTRAPSSSPTKSPSATPTVKDSDRPTASPSISPTKLSSEGPSSSPSLAPSSSPTVVSSRKPSSPPSIVPSEMPSTPFPTSSPITCVARANSCTTGGDVCCGTDVCQGGFCRLIPSTSKQSGYKNDLKLTRATNSGVRGGSFQSVGIAIPDSGPEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY93</accession>
    <name>A0AAD2FY93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome maturation factor RimP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042012185" description="Ribosome maturation factor RimP N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25230" checksum="B08F65B58CCBD8E2" modified="2024-05-29" version="1">MRNASLILSFAALCPYIGAWAPGLHRLSLQHSSRRFPSTAVLLEALPSGYEDIGTQIIQEAGASCGMKSLEDLDIEWKAGRVIVTVRGKVYVSNPDKSAESDEEGEEDYEEVIPEAVSGVDITQLARAINFAMGENEIGNAIAETHEIEVTTPGASDELSGIMFEAYKGFDVICRFEDPKKKMVTEIAGRLHDRTDETTVINIKGRMKTIQNESIESIKLPKAKKEKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ29</accession>
    <name>A0AAD2FZ29_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="6">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS15582</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042024308" description="fructose-bisphosphate aldolase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1955097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="47026" checksum="083F2B5CC61F8EC3" modified="2024-05-29" version="1">MRLSSAFLFLSGAQAFIPGLNGRSPIQKLQSMAGDVGIPCEDECALESFPNLPPSVHPGVLSGQAMMDLLDHAKQNGYAIPAVNCVSSSGINACLEAARKNDAPIIIQFSSGGSQFYGGKGLDNSNYRAAIAGAVSGAFHVRTMAEQYGVPVILHTDHCSKQLLPWVDGLIAASERYFETHGEPLFSSHMIDLSEEPIEENIEICKDYLKRMDKVGLLLEMELGITGGEEDGVDNTDRPVEDLYSKPEEIYQTYDELKSVSDMFTVAAAFGNVHGVYKPGNVKLEPEILNNAQAYICDKLGDAAPENKLPVSFVFHGGSGSDVADIQRSLGYGVIKMNIDTDTQWSYWEGIKIFESKYHDYLQGQIGNPEGEDKPNKKYYDPRECLRAGEVNTVKRLEQSYADLKCQNILGLGMATEAKNVLGPRRGGLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZY8</accession>
    <name>A0AAD2FZY8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(2Fe-2S) ferredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZY8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02980">
        <property type="entry name" value="TRX_Fd_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19597" checksum="D9B7C2EA82D28BDE" modified="2024-05-29" version="1">MESEYDGQQGKIIEVCTGPQCSVSGASAVQLEIEDLVIEADDGFHIQEAGCRDFCTMGPNVYCSGSHFSKVQSPEECERIAKEIGMSSADDADPIQSTVGKMMRRKANRKRWQLLRNIARQKSAGVNKSEKWKKELHELHGLELRAAESSNSASELNQRADRRLKRFLNYVDDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G012</accession>
    <name>A0AAD2G012_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS17356</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G012"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="751"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="796"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="863"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="150"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="329"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="600"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="656"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="988"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1958798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1156" mass="130575" checksum="52213BB54659772F" modified="2024-05-29" version="1">MLARNGRLSTSDDENQEGFVSNIHQHQTSVAAHAISSLETTPEMDDDASSWDSFRSGDPDFTPPNWMVQFVNFRKQLFLQTVEPVIVTLLGPMEEELEDNFLYQEQFSYHAAGNISGVDATHRRLSFLPSYVEDAEFERETTMTMASCVVLFMIMGCISLVFLSCFYHNQKTSPLFISPRRHRLPKLVPPPLPIDGYFSWIKICFFVSDEEIIKRIGFDTLIFLRFHRLALRCIVKMSIFSFAVLLPLNYTGNGGANAQDITDYIQDVVFTDFMRFSMANIRSGSPRLWAHCFAAYLLTGIVVRELLAEYETYNSIRHTYLLSREPHLRTVLVTNIPRHLRSSSKITSYFRHVYPDAVKSVFMCQNLIKLETLVSQRTALLANIEKEVLILCRTEKKKLFQRSQWSTAQAYNKLFSLEELGIVESAQERLAAMYSQLEELNSEVEMEQRRRRRIMSKMDHMEAGEGKQDIDYILAAPFVSAEDANQRRVLGLKGGTSQQEDQDVDYQLSEADGGMQMETISGKEENPQLRSRSPSTVPKSKPSLEVDEPPTLNGKPRAKAKTAIRRYSRQISKEKSFFGRQINPAGPTEKAGYIEEHVNEVTDKAFVVMSSYTAATIAIQSMHSSKPGAMQVSTAPEPRDVLWDNIYISKGATRTRSIIGDFLVILIISFYIVPIALISLLVSETALVSISPRLAQLDKASALFASGIAMVQPLCIVSLQQALPPILMAIGRMEGCVSFSEVQMRSFSRYFLFQVLNVFLVTTIAGSVFDTIAIIVENPETAFEMLGYSLPRLSSFFITFVTIKSVLGLGVELVRTVSIVQSIIRYFLVPNMTLRKARSIILGCRAIDDPGWFPFHKILAQDMLVVVISVVFAVIAPLVLFPCAIFCLLSRIMWTHHHMYVYESVFESGGQFWPKIFRRFVFGLIIAQMTITGQFILKDARHEAYATIALMFMTYLFLRSTRARYDPTSSTLPLEVATVMDISIGQEREAKRKAQEQSDYSMNMSPSEDTLSPTITSVMSEDREIDTNIGGHDPYDLAYLQPVLRANPRAKPEQPFPPSQLGDENTLFGRQDTMVDESGLIDCTGTVRLKCLSQQDRRVINKWWDEQVKRAGPQNFGAILIGSECGTLTIGDRRSTYMNPYQGPETPAPAHGHQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0G2</accession>
    <name>A0AAD2G0G2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0G2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="26172" checksum="A850925F493164FF" modified="2024-05-29" version="1">MLTFRRKKQLSTDASDGDMSVVTKDKSTKSLSQSTIISAPATVVWESLTDIKTWQWNRSLRLDASYVMEGETGKSRIVLGGRRATAPFKFGKVSRRTFTFTWTTKLGCCESTNTVELKPIGINKTELVHTQTFEGKLLFLRPSSKKYQKAVRVMDEGLKNHVESLYFNTLLYDFSNSEMVTPGCSTSTEMTVLSEMSGTNFWDTPKHIREKLVNCFVDKDTEAREPTIYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1P3</accession>
    <name>A0AAD2G1P3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS18087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1P3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1959668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="526" mass="58493" checksum="A4C4DE135B3371E9" modified="2024-05-29" version="1">MNDSETVSKSQTASSETAVEVQETTSQKECCSWHRFDGVRKAQGYAFAGLGNGSIAISNVFLSTSFIYLASKEVGCIDENGRLTPCDIRVHGFYPTTLVTNVAVFAGLLCAFALPVIGAIIDYTSHRRLVGRIVGFLIWLIQTIQIFTLENTWFPMIILQAIVVALFEIHYCLMVSYLPDIARYEVSHDTMTRFNRIFFCLQYCGQVTSLLAVLVVSFVLKFNSIESAHLGQSISSIILLICYTTAWRRLPKVQGPHKLPEGKSLLLQGFRHNFKTVQLLLKSPNRTLKWFFLTVMISEAGGTSLLPVVVSFYSRVLRYNSIDVGLTFFVAVLMAIPGAIVNAYFCRRHNPKISLRVNFVFTFSITMVAPFVLTAENPPWLGYVWGVLWGFSLGWMYSGEQLFYTLCMPESQETEFAGFFVYCTVILTWLPSLIYSTIVEKGYKEQYGLGSLCALQLIAMGTIAMVPNWDEVIEGSKMKLLAPPEPAVELPTTTTVAAAAEGISSENTQDLGGERSDSSDVEIKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G234</accession>
    <name>A0AAD2G234_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002043">
        <property type="protein sequence ID" value="CAJ1960056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G234"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="89" mass="9839" checksum="5970BAB0805E0174" modified="2024-05-29" version="1">MSMGKGAVQVASKKQKLNTCSSTEAKLVGVDDVITMILWTKLFMEAQGNPIDKNILSQDNQSAIRPLQLTTDLQERHATIRPLQLTTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2S7</accession>
    <name>A0AAD2G2S7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2S7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="61"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="242"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="353" mass="39836" checksum="E2042FA14A69007D" modified="2024-05-29" version="1">MAYLFGTGRAHTICLFISIATGNLRHFTTAFVRKSVTTSSQRPSLLRGSNNLWSIEECLEQIDDIQFIDATWYHKGDRNGRQEFLDGPRIPGSHYFDMSDIAASKEVFPELNPKGLRTMFPPMSLFAATMDSMGIDPNKKVIVYARRGCWFTPRVWYTFKTYGQRDNVGLMQGSIEDWIDQNGPVDTQKLEGYDLWAQDIMDKISGGPFTNNPRYPITKTAQRQLLTMEQVLQELDSARKAEKPSRVVVDTRGSSFQKKGHIPGAIHIPYSSLVKPGNSLQLKEQKDLLDILETNDIPKDEPILLTCGSGVSVCHMALVLEECGYPTPFIYDGSWNEWGSDPSTPKEFPNQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3T7</accession>
    <name>A0AAD2G3T7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS19377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3T7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF652">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041976365" description="Amino acid transporter transmembrane domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="91"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1961799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="506" mass="54312" checksum="0068430197C6A6F3" modified="2024-05-29" version="1">MKVPILSLFLLLWTVNASDVVRTVPSRNRRLTSSINNDDNNNNKARRASISSRWGPHHQTLGSSEIFSIRSSVLDIGRGGARKSKKAEGGKASVITSIFNLSNNVAGAGILTLAAGKASGTGWIPSILICATLAFCSSHTFILIAKACEMTGEKTFKGLWSKAFGPKTAWIVDSMVFTQCFFVSIIYTGLLGDIFSALLSKSSLPASLTSRTSIILMAASCVLWPLNNIRDLSSLGFTSILGLFAVLYTVFFIVVRSLDGTYALDPVGKFVAEGLIIPPSFEKSTLWNFDLNSLVLISNLGLAFIAHYNGPSYWQSLADATTERFTKVSMTSYAILASIYLAVMTRGYATFGDVCQGNILMNYSASDVLSTLGRLATGFSIIFGFPLISNGAREGLKNASSALGNTSISDPKNHVKLVTALLIVTTTLAISLSDIKLVAGLTGAVMGSSLVYICPTLIYTKIVEKLKGRDSAEYQVAKRNLLFIPFGLFIALMGVTMTLKNTVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4D7</accession>
    <name>A0AAD2G4D7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002105">
        <property type="protein sequence ID" value="CAJ1962479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4D7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="296" mass="32665" checksum="D28EFAB8C7895D6D" modified="2024-05-29" version="1">MKDSIINPPEKDPNSIMTVADQGQRGLEEKNRSNSTTPSSIALTKDNPAITTPKRISKRNPSTTPEDGAMTGDSLFPSEVAQGQVGLSAKAQLNLTTPLLIDLTKDNPDPTNTKSQRKQPPPSKTAEDGTVQGRPLVAYNKNLKVSKFHRLYKKAWRKEVFGNQAFITWSSRTAESSGRAISKCPGWWADVNMDPSSDAQTYDDIAAFILTGLKAYDPSLGGSMPQLRSSMQNLFSLGDLEDADNDKGSWALCEYFLRLATQCPMVVFDLATAQRIITTDKKLPRFWEFCSCLTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4F8</accession>
    <name>A0AAD2G4F8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002112">
        <property type="protein sequence ID" value="CAJ1962546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4F8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="118" mass="12947" checksum="300CFC353C63279E" modified="2024-05-29" version="1" fragment="single">MSATGTLNNKRTRFAADNETQQIPSTTPLEAAKCVGISALTAIGSLQEPQTTFFLELHSEFLKIKKALENLHKRKTTLQKTAHIVSSTKFKFEPTASARLLEDDKAGVDAIKLQCDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G507</accession>
    <name>A0AAD2G507_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G507"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.590">
        <property type="entry name" value="CpcT/CpeT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010404">
        <property type="entry name" value="CpcT/CpeT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038672">
        <property type="entry name" value="CpcT/CpeT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06206">
        <property type="entry name" value="CpeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042004104" evidence="1">
        <location>
            <begin position="23"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="360" mass="41466" checksum="E85A1BA6633DA7B8" modified="2024-05-29" version="1">MVAKTALLWATLASWSFGKSLSFTSPQGTTAQYQTNFKTTLKCRFSTSLNAVANRNKKEDDDQNSQPSQRHTVYKHLLHHFQGDFDNYRQVLDDRKEKLTPREGGGHENFHCTLVPLSETSRLAAFYFDGNPQRIFRFRYYELLMTAEDDTNDISCGDIEMKLYTLNPELERELRSCSDEPLKWPAMFHSFEINEADKIKYLPNCEIRWSVDMDPVEHAYTLDHDNMSKLDNKKQDSIHAIMVHGEAIVDSTMIPGVKIRILDQLSLYEDTFYINDRGLDPESGAFIYGNQRGVPYRLDRVTRLVQIEEEDAQLERQIFDEDLAWTMGESWRSSDEYNAKIEAIGGLSAVMSGKKPPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5Y1</accession>
    <name>A0AAD2G5Y1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002148">
        <property type="protein sequence ID" value="CAJ1963579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5Y1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="541" mass="61384" checksum="CCD4F5893E199A74" modified="2024-05-29" version="1">MEDELHPEVRSDRTVIQSPKGYSCFCGQRGKKGYFKRHLQSKQHRLTSVALEDIIFEQKDDPICKKGYVCHPCQRFFGDKSNFVKHFLRKEDDTAACNGNRVDTLQECMVYETLHYCRPVPPLQSGDLLGDKEISTTIHVPTPSSNITNSATGSANMIARDTIKMTINAGKQLAKQLVQDYGAHERMVRIIQPFVLSSIEATPLLDFLKTGNEKMKETPSHFIAGAEEWLMEHSAMMIGQLMGNVRHEIVAFRVETEYESIFTCRDKTGPILTELKKIIQYTWRSFGLPSGFVDEHDPTEVPRYLHLLAVQSGQSVIHKVPAILKFLSFRIFSGTKQLKGSFVIGSTMATLLYLCRLGSLCVAYRMCGENFIQRQLDLCRQVQCGQVVQTISPLIRQLREFEKFRKTLRDGDYITNEGDIFVGGNKFEKKVWSRLVPKIEDRLCDLFGQLLIGNGQLLLSVLLDPATSPKTTSLDGGFGFQVTDQVGSANFCFEANETVMEKIHKLIQLVFHGLGFGAMRFQEILEMEDCSTPRFFNNQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G742</accession>
    <name>A0AAD2G742_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS20437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G742"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1964030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="93826" checksum="DCCFB0B85FAFE1A0" modified="2024-05-29" version="1">MNTESLVVKERSTENENGPNLSEVEFADSRTEQSPSRNDVRKEDIEISATEKEEIDTDQPFRESPVTENKEDPTKRNATIVDQQQSNKPEMYTESNDIAELGDSEPPVEQKSTEGVDLPAEEEKKDDEELVRDADQLKERAKAMVDVESPSEQAPADSHKDSTKGNAITMDETETKRNTISSDNNESPSVGQAEESRTRRGTCRNLVFSVLFLILCGGALLYFLVFNNNADTTTTSSLLNDINSGGSSDSFSPSSSPSTTLTGSTNASMSSGRPTRIPTRAPSLFPTISGVPAISDATYAVSSSQPSKLSSVSESPSIGPTVELSKRPTIRPSESPSTGSTGPSIQQSNRPTPTPTNHPSAAPSDGTLASTGTPTDHPSAAPSDATLAPTRTSTDHPSILPSEVALEPPTRAPTIRPSVAPSTTTVQPTRTPTSLPSVAPSQVTLDPTAPPVPTTSPTDLATMRPTKSPTRVPTTTPSRLPVTLPVTPPPTASPSVAPVSPRPTSPPTRPPDPIPELGVKLRNYLENDFGVGIESTNGNQAVAQLLEEARADGELPLTPKLVQRYAMINMEFALFDISASGFVDPIVRQNQRNWGALNQDECSWSGIKCNGNREVTDVKLLGKDLQGSIPSEIGMLQALTQLDLASNKLQGSLPEELYNCVSLKKLFLYQNRLTGTISDKIINLWSLTDFNLSSNRISGRIPSTMRSNGRGIYRIRTFNVYDNQMTGSVIPTLDGANLRQLYYLDLGRNRFSGILPTFLDFVRLRHLHLDHNQFSGSLGNVINSGDGRLQVLTVNDNKLTGTLPGWHTFITEMVQYTAQNNQFTTMIHRTCKLNVMETGEMPEFKSDCDVCVCGKDDQMCKNCYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G774</accession>
    <name>A0AAD2G774_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002095">
        <property type="protein sequence ID" value="CAJ1962171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G774"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="119" mass="13461" checksum="C5E5D3971ADC4175" modified="2024-05-29" version="1">MIVALPQWRQYASLCRFASVTLLACLKEPLVLPATGILTMLDPVRAKFNSAGLLQFDFLHGDFIRWLGGEYVNSAHDFNAEWDVIDSTLHNREVPAEYPPLKLEMAYRIQTEGVPIKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7R5</accession>
    <name>A0AAD2G7R5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7R5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="882" mass="96604" checksum="6BED08578EB25D84" modified="2024-05-29" version="1">MSRQSPIPAGRAAIADDDDPVIPRRLDLSLNPEDGSLLTAPLLSVLMAVTDSLYSDLYHMAQGEVDVTSSLPVTGADDPEESEDQPQQPQASSLKKERMSNLSFAQRRHELSWRLMSHGKSLTHVAALTAAAASADLATATQVSTKALQHARTAWVQADEAQDALFFFHAQLFPARQAPHDVYGALDLLLRGSWPDMPQDLQLLVDRYENSQEKSWPSMETADRWHMAVREKLLLGEMGWMKQKGIQVPWKISLRGGVVRLTHGTPKAIVVDGERKKTYPMEAVLTVLDSTSTPANWTLVSVEVHAQAKTGQSNHQLDTSNRQRFDIHRLCALSMAREEARNRKEGGEGKEQQPQQQPPARPLHALFQVAHTFCLSWQLEILSAQAQALRKGVWGSSSSSIVVTPAQFFQNRSLLGIVSISFWSIDDRYGPPCMGDLHVEDEEEDSSTNKESSGTKQSSSDSVSTVSRSINEPSVTNQLTLSVRAEANVGIRVALSGADTIMEFASAQPHTREAIQQLLNATSNPFCLSASEALLAATHLCAERKCQAMVNVLPDFLPHWIHLSLDRASIVVAASIEYDGIVQSEKRGPVVLFRLTCDARTGSFIPTFSRSTQLLQFMACNDPKAASESATLRIATLANHRRASRAVGASMATGRSVRDVFQGLVRSINVLGQRTGVGGSWKDKDDMSSSLRLRAVQTACKDVKVSLQNCCGMAAMYGLAALSFGVATGVSAIPDMAGGCLEPNRGNGKKFLLAPPLSLLIDQHMIETTQRTSDGDKTQKIYTEQELFGTCCAVDDSALTVYGLKINTRLDTPSSVPNRTSWELKRFHQSGPQLIPMEVEDVRPMKRARMTESSNGGLVAHDMTKEVEYFASVLSDTLEMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G899</accession>
    <name>A0AAD2G899_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G899"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="38"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="243" mass="27815" checksum="70777E102C34A3F0" modified="2024-05-29" version="1">MTTKSMPKRRRPRREIPEDLTNLYLEKGSVPSSLDVITRGRDFQHTYEKNQRYWRRILSERKGYMQLSKYEHEARNAIVESIYDYVRSSGGRFLQLDAKSGQWFQLPKKASMHEIQQALNERYVPYFARSQPQPQSSAPKKASRPDTSAFAAFLTNASSAPKPTTTSNFFSNFSQSSLQSSTGSIDFMACINNNNNNNNNMSNATYLQRVPKLKSMNAYLEDHMNSAFSNSMNNSNSSLVEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8F1</accession>
    <name>A0AAD2G8F1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M10 metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8F1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41090" checksum="0A6BA907D2D93B2E" modified="2024-05-29" version="1">MQVSDRTKHCLALTLLAGLASYVIWHFAGRPEVDIGTDFSGIWADLWNEGPELSDNTTYYWRTGGRGGLTLDLLNLLDDTWQGEYDIAANDWEQGDPDVLTLRSEKGVSNMPCTMAFGVMKICNENYGDTGWLGINEIIIGGSNQRTIESSLAKMNDYYLGRASLEERRYTMCHELGHGFGLPHTDENFNNRDLGNCMDYTNRPRNNLLPGRDNFLRLQEMYGLPNQRPLDPVSPNDQPVTPNMFDPNNRPQAEENAPGEDKKEKKENKEDRNLRSRTVEEPSEGQQEHSELPRHLAREYKKAMAELEHHMQMQQLESDEVQGSGWRRLEDHSHGAEFVRRLGQDHHIKVQMLYASPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9T8</accession>
    <name>A0AAD2G9T8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9T8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="162"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="380" mass="42822" checksum="FBE6BE07DB5E9FE2" modified="2024-05-29" version="1">MEYRGAENLGLGHDPMMEHLGFTSSFHNRPSYGKPLSTSHRSNHLREGSAGSYSEHRGDVRKQSYGSQSGGIPASYSWDSKDSRASQRSGQTTDSQSRRIAGGSNYNHNKRISRTKIAQEERSQRTSHDRRSRHEVRREHTTVDEGDENFLHTSDNVIALFGAYGTTGQHFLQFALEAGYRVRVLLLPGVQLDIPESKNLTVVTGTLDEEQKIERVLKKASYVVCMLGDCTKIIEEKDGESSHSNYRFIQRLVSILERVRSKRVLLYQASSVALDNEGSTPILSSLVKKMQITKAKREALAEQDKIVAYLSTQLDQDSCRYIITRPSDLIWDKPSKRKLAASKSQPGPFAITNIDLAEFSLNALKNEKLYNTCPYVVKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAF6</accession>
    <name>A0AAD2GAF6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAF6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="299" mass="34581" checksum="44DFA702BCCFCB73" modified="2024-05-29" version="1">MAMQEYLSLLLKERSADTIVFVRDDAKVEQDRRIEFNNRTKQTNTTCPWKPLSKCRAPTLPSRTNSVEDLGAVVSKLAECEKQVSRVSSKHPSFDDEEDDDENADFSPFDTLSKEFMLQRPLHKRNSLDTGLTKISSVPLKDPDESPRSRSRNRVFSDSYLETQTPNVLIQHERRRSEDYLTLSHAQHMNLNGGRKINRTGGSIRRKARNNSTEAPPVIPFRKESDDDLAWSSSKQNRKEDQEVVETSDSTILNSTWEPLQQEHQRVSNCQKKKNLLSFFTDTLSDEETRWLSLYDRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAU3</accession>
    <name>A0AAD2GAU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alkylglycerone-phosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alkylglycerone-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS22599</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycerolipid metabolism; ether lipid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.26" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008609">
        <property type="term" value="F:alkylglycerone-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025650">
        <property type="entry name" value="Alkyl-DHAP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568:SF1">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="13">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="14">
        <location>
            <begin position="1821"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="2205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="1924"/>
            <end position="1930"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="1937"/>
            <end position="1940"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="1994"/>
            <end position="2000"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="2142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="10">
        <location>
            <position position="2046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1967071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2289" mass="255702" checksum="4E5DCACE7A027699" modified="2024-05-29" version="1">MEEIFLTVSALVRNSDPSNGETTSTDEKLSLYGLYKHATTGPCPGDALPPVYQLKARTKYQAWEACQSYTKKEAMEKYVRLLASRNDDLGARCTALLDDFRKQQDMSEIGSSSETAEDNYSSSLKSEDASRIPGMDRTKMDSQSYTPKNLLSTTLDLLVSIFSSSLRLIGIRAMIPRGKLDVSFLDLFFALYHCLRWRGLQGRCSVMVKEIQDIWKNSTGYEVAVGFSVRSLFDLYLSSKQYPPNAEVVVFPPITVPGMIHVAKWHNLKLVPVDIGESTWWNGEGIEQAVTEKTVAIMIVHPFGMISTSLDQIEKLRILAAKHNVELWEDCAECFTGFGERCYLGSKDADVRFFSFGMIKTATALGGGIAIIRKKGVAQQIQRLQHSLCRRQSTIEYFKRVVLSLALNAVAISPHLFGFLVSCCSFFGIDYNNFVTRAIRGFPVSNTSISLNGDRVREAIMRQQIRKQPSPALLALLLRRFKQSTGIAPLVAERLARCTMLDTELRKDCQQIMLPNPPTFLHTYWAFPVFYDNREYVSSELRSRGFDVVSWASQLCHVSKFHGDNHLCPRAARLMDQVLYLPISSQLIPVHCTKRLVASLQCLLAGAKDPSLQRTSPRLSSTLTINWAMTCLAVILSVSWKYLGWKTVHFLQSFGTLVFLCISGCFGIMTLFFHLLRSRIAKLYLHHESWFQHFDMIEAATCDELLQTETEKHQGEGMLAKNEVLRLPNVSHNRGEERKALLTGATGFVGSLLLRDLLFHRKQLSMTGGVILVCRSRGSVSAKERIASLLAKPMFNFVSDDEKDRLVEVVEGDVTQPSIGLSKTDLSRIVQDDAISHVFHAAAAVSFTQELPDAAKSIISSTLTMHSMASKLKRGDVQFVHISTAFIHGNKKGSISSPLKEDLFPLDPYDAREIYRSMLGSQFYATKAMTELGFPNTYAFSKCVCEHLLLERNNLNTLIIRPSIVGPAVTSPFEGWAGGKPSTLVAASMLYLSVPWNIWHLPNHSVPYIPVDVLCRFILSQAYLTPQLLGDENSTTSNPSSSTGGSFQEVDNINEVCSDFSDATSSIPSASATWQQIKTATMQGGARGDTMFTWLDFGVAQCHLAVITGSVSRALAQFALFIAAKVMPSKPPSSSLYHRLHGCFIQQPIRLLVSILNWLNCADGGLGKISPFLELPLLFFPFVKEPFHFQTDLVAGDDFDAKRYAFSCGVAAHRFLLSLRTRRTKKSEKKRTQNRRLSTGSIKCYPIGGRRLQPKLSDSLWAISQPRGSYLTRLTGMLFRKILRHVSDAVTVDLLSFRRISGVIRAAEEDGTCIILAPTHRSFFDFLLLSYLFFSIPELRLDIPFIIAASEFEQLPLIGILAYYLRAVFIQRGNGSPEDGLSTKLATLKKQNSSVPGSCIEIFLEGKRSRDRRFIQGKTGVLKSLAESGNSHTIIPITVNYEAIPEQNRLSDEAVGSPRQPLSLSGLFLWLQDVLKGNVSVGKVHIAAGIPIPMKCQQPADYRTLVTQVQLAQQSQIHISDYHVSATASICMVDKSKAREALEQLGCTFWPVVDDERFQCNTPHLPSDESTLCSVVLQCSHLLAPLFIDEHKMWAVWLNYIVSENDRPSQMSQKVRPVYDIFRKYFIASDKLVDKTILEIDRRGYQHPNENYILQIATSLNDEKLPLLFVWASISMRQIAFTRGERKTSPLPESLQSYCLSDSMENLGFWGFHDSGFVLKSDGDRQSYVSMKGKRYGLCGKQLPNILPFMESEMRIRMATLNEFSSNSIVWQTPYDSKFTVAQKQNLAEEFSYISFATIERVRHGSGHSQEDIYLIRTGGSFRIPDAVIWPQSEIDVDRLVAISRRLGYCLIPFGGGTNVSSATRCPTTDVESRPIISVDMKKMQKILWVNEEDGIANVEAGITGRELGEELSRRGWTMGHEPDSFEFSTLGGWIATKASGMKRNRYGNIEDIVKSVRVVGINGKLWNGDESGKTAHGRVAEGFDLCSLMIGSEGCLGIIVSAVIRIWPLPEVREHDSVILRNFEEGLHFMRAVERLGAHKPVSVRLLDNAHFRLGQALRPADGSIKARLQKVIIQLASSMHKGYDFSSVVCATISYEGTASEVNLQKKMMREVSAAHDGMTLGSEIGKAGYDLTFMIAYLRDFAMTYHLLAESFETFVPWSRVGTLIRETKNRILQEHQLRLLPGLPFVGSRVTQLYHEGVCVYFYLCFSFEGVNNASEVFSELEKAARDEILKHGGSLSHHHGIGKLRAEHLKEVTAPTLSATIGAIKKAIDSDNIFGARNGPFAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB17</accession>
    <name>A0AAD2GB17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="106"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="311" mass="36054" checksum="4A19A846CF6DE161" modified="2024-05-29" version="1">MPGRSIVSTTRTTALPSFFSRSRTPSGRKDATINFSAQTNSRHSSNNKSSMNYGSHSLLKSLQNINIALKEASLGSSVSKATVYRYSSFYSFNEDQALKAICQAYHQRYLHLTMTGDLLAQFQTRTLFPLTGLKTRDLKCNVLYMRPCRFVPEEMKTSNVIDNLCYVLNDLSQTKEECLNGVAFIANLEDWTMKNYSHDYCIQFMEALQGKMVPTKVELFLIVNPPRWFGRIWKVMKPMLSKSFSKKVHIIKEQRLGDFFMEGYEQYLPMEFESCGWRQTEEIVEDYIDMKQYENEQKLTKRSKFSSDCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBU1</accession>
    <name>A0AAD2GBU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cathepsin X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS23630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBU1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="7">
        <location>
            <begin position="339"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="504"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1969288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="90272" checksum="715AB00A4DD79F9C" modified="2024-05-29" version="1">MAERQMEAAQRARRQPDYDSDDDVSSVDINSTSGQQQQLQQQQQFQISSSLSPTNELESFDPYRPRQQPASDEALFDATAFELSSMMGEKEIKKSTVPGGAGYLEIEEEPPRPVPFEMSLDNNEPIRTSSGLLLTHRRNSPTSTFNNRTRATPRGNNNTTAYDSYVKRRQAFEMENGLHGNPGGYGASSYGPSGRHSMAMSQGKQILSYAKVWIVVCFGALLVTTGALMHSFGSNEIENESVQKKNDAAQASNQNMGQYQYQNNVAGGQNAYYYPVSEQVLLVPMENISQLAAQQQGNENYPPRRKLGLSQLGHNQQHQQHHHQQHYEHMSLHKLRMEFENWMSEHKKNYHSHKEKEHRFAIWSQNHKRTKDKNRRHGRCKMTKQEVFGSNHLMDLSPEEFVGKFLTGYKGPRTDEMHTASLGMGFRRLGKQQTGKALDPKVQKAKIHETVKRRMLQQQEPVMKSKMNCKWYDVSCVLRWLYSSSGMQFGLIGTMEPKYDADTYPNAVDWRDSGAVSDVRYQGECGACWAITAVETVESAHFIGTGNLYDLSEAEVITCETSCSMCDGGWPQNAYQYVMDHGGLPLSNNFAYDSYTLLEMTYGLSGTSSYWTEDSVTSKRSEVCPAADEGNNDKSSGDEYYDGGGENNNYGDYSSQGRYGNIKGFGYATDRCICYSDGSGCDCDDQDESTAVRNLASYGPAVVCLEASLWQDYSGGIITSDLGCGTQFLDMNHCVQVVGYAYTDSSNNNDGENNGNSGSGSQDDSAREGYWIVRNQWGNSWGMNGYAYVAMGENTCGILNDMTQAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBZ8</accession>
    <name>A0AAD2GBZ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS23102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002369">
        <property type="protein sequence ID" value="CAJ1968147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBZ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1968147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="319" mass="34912" checksum="CA7F1C1FFA78569A" modified="2024-05-29" version="1">MMQVETATTSTSTTTTSPSNSALSPLSPRLVSICEEMNPSKRSTMEDCCVYAPEGTWDGPPDVAFLGVYDGHGGRDMVEYLEDGLQWHVAQELCCQNDDAPMATRLERAFLMADIHSEQLGVSMSGATVAMCLVKKHSTNKKDDDDSSSLRTIYAANAGDARIVLGHEGKAQRLTHDHKPDDPVEIERIEKAGGFLFKQRVVGVLAVTRSLGDHCMKDFVIAKPYCSELEIRLPSANHFFSEEEKEGESRESGESSSSSLPSFLILACDGLWDVLEDQQAVDMVWTHGAHDPHNVAKHLVKEALAKGSMDNISVVVAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC00</accession>
    <name>A0AAD2GC00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002369">
        <property type="protein sequence ID" value="CAJ1968181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042103893" evidence="1">
        <location>
            <begin position="27"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="392" mass="41072" checksum="847547FB0683E9CA" modified="2024-05-29" version="1">MVPTFTNVVASLALVLLYSLAQVVRSQSLSLRQWAGNENQGSIIGLTSNDKPPPDAFANQEVRPPFIGNDRNFNSGDIRNGSVRFFRKEQGSSASPSNELTNLTLFGNSLGGDFGHAISLSGDGNRVAIGAISSGNVGSVSVYEMVNEAWGLLGVIPGEVVDSIFGYSVSLSKDGSRVAIGDRLNTRRNAGYGRVYEWNGSSFLKLGANIDRESISGGKTPSDIALSEDGLVVAIGALCIDVGFGSYFTGVSVALSGDGNIVAVGINKRVQVFEWKDAEWIQVGQTLKDLGGQIYSGESVSLSSSGSVLALGSDRVAPQVYILADGTWLELGGIIGSFGGHLVSLSSDGFTLAVGDWRSDSVSIYNLNELLETTTPTPSPSAISGPTMAHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC69</accession>
    <name>A0AAD2GC69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS22413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC69"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="267"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="634"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="854"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="896"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="925"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="957"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1049"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1966830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1120" mass="123609" checksum="96A4112ADA816752" modified="2024-05-29" version="1">MGKKKSAKKRRSSVKSQAELKSLRRVSLLDSATPEPKEKAKLSKGTSPPSLPEKPVSDNGKSTRQRIAFVLPRVPGKKPQAYVFDKKRQKDKSNKATQPTIQEDDDDNGISNILKSTETIDDILFPNRRRDSSEDRQLLGAEPMETDASPRKAMISGGRFMLTQASTFNETQSTVEKRHELNLQSPKSKEDRNQRKLSDPTSPNSLGKLSGLSVEDAVKDKYGLRPRANSTDGELKLPQRGLCDERMVLESHRWKEDQNYVHQVVPKGFINLGNTCFLNATLQCLAYLPPFCQSILAISESKQRLSKKMKKKLSQGQRITTILSTLYKKIHSFDETNRGDAIAPHGIVKTLPSIGTCGSRNGYKFRPGRQEDAHEFLVHLLDAMHDGELKAAGINQQASGWRDRLPVPRLDETTFIHRIFGGYFRSQVRCGSCGYCSNTYDPFLDLSLEVSKKTCRSILHSLADFTSKETLDSDNRWKCSGCSKHVRATKQLTVFRPPLSLCVQLKRFSFEGGFGARGYSAYGTRGWKYGKSNNKFGGGGKITKPIEFPGHLNVPLSDSRSCQYDLTGVVIHVGGSASSGHYTAYIKKPGRRGKDQWFHVDDSFVEAVPEKTVLRQRDAYLLFYCRKEVKLEFPSPPPQGMSASEAMKVMRARAKARSDSFGKESPSEINSMQEKETTSSVARSPSVFSKGIIDQSDSDSYDSDFDPTKVADSSESDDSVSVDPEIHERISEGTTTVMKRTVATTHPLSSPLLTKKGKNLGKSESQLGQALFKMSLPNENVNELESDSSDSDFDPKDRLSDEDSDLDSSSVENKSTINGFGGSKPSASSGSDDSSSSSDSSSSDDDSSKSGDSQSDDDGSDDASSEAESSAKMNVPPTNRRADVVNLPQSRSNDGSINSKSDSEQSSSSSDSDRPNEQKNSKQNPSESSPIKSISSSKASVESSPSAEKATSKRTRVILDRKDAREKIQVMMGPKKKKHWQSKAATVGAKGDGFDLLGNLSVSKWDDEDDTPVGDSQSPSKSSTSAERQKIIAKIHKHESSRKRKHHLDRWDAHLDQGRLKKTKQDKANKQASMFGQFPKNNVFQKIQSSVSRMKKGKPKGFFQAKGRVTSTAAGHRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC82</accession>
    <name>A0AAD2GC82_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002370">
        <property type="protein sequence ID" value="CAJ1968244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="260" mass="29884" checksum="889B53659DFA61FE" modified="2024-05-29" version="1">MTGVGKFLAIWNRLAKSSCPRCSSCPVEDHLHVPRCSAPTAAAEWSKRHLAFRTWMQTQQTAPEIEAFLFDYLKTVRQPSLGVPTVRAWSRHPHLFRSAISSQATLGAQGLLEGLVSPNWRHLQALHFSYIGSKKSANLWASRLIQQLIRIGHYMWKDRNRLAHSEDSSWYTARKREIDIGIREQFAMGLMDIPPHSQYLFRDSRDTVLNKSLKDCQHWLRLVSRERAINRRSLARQRQMIFDLARPANPTSTRTTGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGG6</accession>
    <name>A0AAD2JGG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="199" mass="21562" checksum="02E9553CA9CAAA8D" modified="2024-05-29" version="1">MISLQDTLKLNNYAVALYQSGDITQASKAFSPKSHSTTSTPTVDPFVYQSLLILRESQAASSSLPHDEMQLMTLYCACILFNTAILHHQESIKTGSSACLDRAAQLYEASIRLVGKFPTTVASFNNNTISLLALAASNNLAQIEFQKGLLDQASTRLQVLKHLIQSLQHVVLHIFTVDEFDGMLSNSLSAEGVIASSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGM8</accession>
    <name>A0AAD2JGM8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGM8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1947751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48452" checksum="D2FB77E02DCC29BF" modified="2024-05-29" version="1">MNGSELDSVEKLLDDSIVYINQRNPQKAGELLERVLEIRTKEFGEDALSVGLTFYYIGNVLRMEERFDEALEKLNRALAILMKESGENHAYIVNTYELLGRVFLQQGNYEKAEEMCRKVVDLQGGFHAQESNLMDLSQNLALSLQMQGKFSEAIKIQKVVLVKLLQIHGEDHPDVVLVYIAIAGLLKGQKRLDDAHQMLDKSIEICYRLQELGDDFDTVNLVRALRTKAGLLEEQGNMEGSTEMLHKVTMVQKESLGEMHPSTAEAYEKLAVAYAKREMQEDGINALNKALEFRQTVLGEDHPDTKKVVGFLIMLNREKIAKALRLQGLALNAKGDSAMAIRLFHEALDVYKEIYTAHPKMATVYESIATVKVEQGLLEDGIAASAEALKIRRKMQGDDDTDTKGRMEAHRSLLKRLLENRNEMRELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGQ9</accession>
    <name>A0AAD2JGQ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGQ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="790" mass="87394" checksum="C1116F6D79C8C79A" modified="2024-05-29" version="1">MNARNYSPSNTTANSKKSLVVTIQHHGDSNNDGWLEDCRQPPAKSFRSFGSIRRQLGHRKKVLQQEKEQRELMEQPQNDSTEEVEHELGKPFLSSFTRSHLRKIRNKWKVEESESIVFSDDENVITDDIEPNSSMNQMQDMEVGSTCTNSKRWKKKKDKKRWLSRVKNRALTLSGKPHVSLGGTTKGNNKKKNRITVGNKLKTKTKPASEELRTSITRPSSSSLSSSLGHASALLPTPRRLQSQDEEYEVSSADRVAVGLDEELLQESTNGFLPSLPYPKGICHMGDKAVSQPKVHLQTAYTPYCYSSDDDSYRRETLYPKPRHPSGEKATVRLIGRATASYHSEFSDDSSMGSIASIVVRMDEASSRYSRDSSGFAGLLSQQGSLPDEEKGNIRIGRTIVGILDSDAQSTSSIESSMESIPVLLMDSALPCDILHIDGEQDASKCDSFVPAASGNEKALDAKVESSDPNQEEETDEQDIHHLNISFDSILSPSSSKQQRQAHHFHPQHAANDSSPPVSPIQPTILEVQSYDEAFRDHLDDIPVQENKKSSMIRKLLSCGSVINTTRIPSKRKALKEKAISLKRRITQKITSKNSVEANENASASPTTSLSFASSPISSTPGSPSSGSMVSGLSPDRMNENTRTTSPPRSISENKEDIFTTPEHTKNRKPFDYRRPAPTGPRECCRKQSSARNASVSLILDSFVRLTKKNHQRSARRTRRFRHAMSTLRGKKLPMLIAIGLAALCQSILTSLDASNSLNMLCGSSNPLVYGFTLDAISLTSFAQSMIAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGT8</accession>
    <name>A0AAD2JGT8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="334" mass="36704" checksum="B916205BE4C7B357" modified="2024-05-29" version="1">MADEEFLLDCDSVSNLSSLSGLTFTNNDAFHGTNSRMWDLLSVASDYASLEEMSFEVEYVDDLLISDNKQICFFDHISGPRSVVSDDGFTFETISTDDDNDANEDSYLVSAAHNDSTCFEVQSDSESSDDDENDTDLFSVHSKLTSLDQEEKAAMKAAKSPTSVANFGDGSRAIFSVTASSAPKANSAPANNWRLQRARERREQALKRCNDVLNNETAVPHHHSQLTTKRQDLINLVSAIEAMDGSDILATGTSQLAKQASAPASSSTLAGRRRRSLEELRSRQRESLQGLISAFHAVCDNKKAQTNTRHYNQYNNKKTSSAAPTTQQPIFTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHG8</accession>
    <name>A0AAD2JHG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS12015</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1949281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="48918" checksum="1A95B446D9B5E530" modified="2024-05-29" version="1">MANETTPLVARPAPGSKNRASGTTGSHARKRRSTMRSKKHKATKTGPPVLGNIFEAKDEPSSRPERRVKSWMYTLLNPKSLQLHAVIFKYFIATIIVADFLFYVVSTEPVYQKELPPLFAWEEAITSYLFLFEYIARLWTITEHHKYRGQITGRLKYLVSYSALIDLFATMPYFVEEFTTYELPQLTYLRTFRLFRILKTNSFMKAGDAVRRVLYYNRQIMTLSVFVGLYMILFTSLLMYQLRPRETESKEFESIPSTMYLATLMLTGQGGPEGDLPWYTKAVVLVTSAFSIGMFAIPVSMLTWGFEAEAERCAKRSRQLAKREASTNNIDDVSTDEYSTDEDYQKIIAGVESSSSSDGDDSAIARVMKAAFDTSDVDGSGSISFEEFMKLSQSRTLEAASLEGRVAVLEDKLDEAIDKIDKLCKHFAVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHT6</accession>
    <name>A0AAD2JHT6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protochlorophyllide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS13431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041907877" description="Protochlorophyllide reductase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1952200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="43209" checksum="0726EB419F1A2D97" modified="2024-05-29" version="1">MRSLLLALLVATSFVDPSQGLLLPSPKKVLVKKQICRKKFLAGVAGAAVLGTATAAGAAVAVNGQSNDNKKIYEPAPGSMDGKVVLITGASTGLGLESAKRLAAAGATIVLTSRNQAKGEKAVANVEEYVREQKGSTPKVYSLVLDLDDLENVKAFPNAYKALGLGNISVLLNNAGVMAIPDRQLTKDGYERTFQSNHLGHFVLTAGLFPYLSRDGSTVVNVSSEAFNFASQTTESGGGRGLDMKNLNGDIAYGPWTSYGLSKLANILFTQELQRKADASGNDWLTTVCLHPGAVNTDLGRNIMGEEKWNELKESGGASASPLTMFALKALSNFVLTVPEGASTQVFLASGAEGAMTKGAFYEDLKEKKSLPGFARDTAKAKALWETSETLGGVKFDPASIKAAGAAAVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJS1</accession>
    <name>A0AAD2JJS1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJS1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAG-pre-integrase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="290" mass="32741" checksum="4744D551B6BBBFE3" modified="2024-05-29" version="1">MDNKNFEKDPFDLCGETAPILADTIAGAFEEPALKDFNFESILSEDWDSTAPEARLPSLNETDKRTLMLRWHYRLGHMPFSHLKASAAAGLLDPCLATVQEHPFCPGCQFGKATRRPWRHRSKKKDGSRKKLCQATHPGDIISVDTAESQNVPGLVAQLRGRPTLMRYHYATTFVDHFSDLDYVHLHQRNDGDSILEAKLAFERYAGTFGVSVKHYHCDNGVFADTNFKTACRAARETSSFMGICNDFLLSNSKFHSSRGRETDSTAGIVNTDDRPDVKQFQHCRNCEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKF9</accession>
    <name>A0AAD2JKF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001988">
        <property type="protein sequence ID" value="CAJ1959283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051049">
        <property type="entry name" value="Dienelactone_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46623:SF7">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46623">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="247" mass="27295" checksum="6570A184A17126A8" modified="2024-05-29" version="1">MSEFRCGRNLELRSCHMLPLPPIGTSCCYNGANTRATNGLAEELGCVVIAPDTFRGTTTTFIPKAIWLALSTPQDRVNDDLDSICSYVESGMILPDSSTTALRPSGSGVAKANQSSPNKSKMRCKFAILGFCYGGGKAIRYTTQRRRDAATVVFYGMLVTDTQELQNLEAPVCGIYGRNDVQFPIPLLEEFQNALTKAQVEKDVKIYEGVGHAFWKNMEGVRHGNQPQQQALQQCTTFLRKFFDSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKH0</accession>
    <name>A0AAD2JKH0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="250" mass="28584" checksum="BB78A77AC92E5CB7" modified="2024-05-29" version="1">MGTKQRKNAKKDATTEPADKAGEVKPDVGEQLDRALEALMSGKRGMITLYVQWRQQLLRMGYLVMLAIMHQLQKPTTLCLKEIKEWNEIRKNSSEEPYSGLQATFMVLEDSIVEILGLICGICLILCLQSPVLNFKDFSTIYFRISCLGIPVIVYLYHYEKQYLGCLDDQDYDALVQSRRQAAEMDGGDGIDPAEKEKRGFPIILIYHVITTLALYFMKYQSEKTDKNIFELLHLKDELTEARKGSKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKZ1</accession>
    <name>A0AAD2JKZ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKZ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042074761" evidence="2">
        <location>
            <begin position="28"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="523" mass="59022" checksum="A3E7ED46CFA6BDC5" modified="2024-05-29" version="1">MSRIAESSLVLSCFLLLALVSLPTTESYITFKTYIPPTRQRQWLTQLTGDICDSPTGSRLIDSAPEVLRGWSMSKEATVENAMSVESLFKRLVEESKAGIRNVNPTTLDYNIILNLWVKSQGGVFAAERCEQILTTMQKLHQETNDFSIQPNLETFKSALLAWKNSRVPFAAIRAQRLLEWMIRLYESGENDVLPDSDCFDICLQIWSKSDNDPRAAHKAEQLLLTQDKLSQIVHSHKLKPTTLSFNAVLFAWAKTITKESPHKHKKMVALLALMEHLYFEMANTRVEPDRCTYNTVLCALAKGCSPETAKQADTILRSIETHYKNDEISWDPDAILFNTVISAWAHSDVPGAYRKAQSILDRQLNLYYAGCQDCKPDVIGFTSVLSSCASEPKKSERAKAFNVALSNIQALEKNPAFGKANHITYGTMLKACARLLPAGSPERTKWTRHFFQKACDAGMVGNMVLNRLREATTSVEEYKELIQGYSKSTLPKQWTCNVQERGGYFRNPKALLYANVKQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMF9</accession>
    <name>A0AAD2JMF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS20031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1963159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="338" mass="38206" checksum="737B1F8F5837518B" modified="2024-05-29" version="1">MANVTDPLIAAVSGTDPQNLMEYITRQKIYDSRFWKEECFGLSAADVIEKATKSLVCIGGTYGGNHKPSKFLSLTLKLLQLQPDLELVLEFIQQDHFKYVKALGAFYLRLTGRPAEIYEHLEPLYSNFDKLRYRDVTEWKLVHMDEFVHDLFTKPIACGISMPRLPHRATLITEGYLEETSGPGGLRKTALDEKISEAGGIKEYLKHKMEVEQSEGAAVLWEKFFPDEVDTKKKKKKKKESQKDAGVEQSTEDGELEDSSSKPQHESSKRKHGDSKEDKKKKKKKPKYGSLFKSDKPKKDKNKSSAPQEIGSGGAGEGTDEYWNEQRAKLGLKPLNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN49</accession>
    <name>A0AAD2JN49_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS21330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002221">
        <property type="protein sequence ID" value="CAJ1965738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN49"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="260"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1965738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="454" mass="50115" checksum="1FCB9B5E60767D3B" modified="2024-05-29" version="1">MGRFLSLRRDLCTSSSISRYDASRSSTFRPVEATKSDFHIEYMDDTIIEGTHGYDTLTLGDIEIPNQVFAQASSVINNTKLCNEVGLLGLGLREISSQNFPALLSNLKEQQITMFSLYLTDHNDYQLFMNKTTDSAYPIPGQPPASAESEFTVGGVNPKRYRNCLRWHELGQFRAKGKAFKGCWDFALDGVKVGSTEIPSSSLAMVDSGATWSVSSQETVGRIAKKLGVKCFVCTDSVEDFLEEVQCDDPFGYDFAATYCSETESSTSLTFVADGKSYHLTSSEPFREIEVDSHSPICTLNLEGVPGFPGWLLGMNFLRKYYTVFDFGRKRLGFAEATTNSATVCKADSSYFIHDIPDDAKTITSTPSASPTSYYTPTPHYATSSNKDVSGALSGFIFFVVGSFAGFLFVRFFCVGLAIGYRQQAPAPTTKGYLQVRTTDPEECTREVELSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP25</accession>
    <name>A0AAD2JP25_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hexosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002395">
        <property type="protein sequence ID" value="CAJ1968639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP25"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36387" checksum="62F9A985A6FBB794" modified="2024-05-29" version="1">METATSAVVCMLTAGVESEKKATRVVFTARNYIEGAMALGQSVNSNIDTSKTHMLLLVREGFFLDPDDARSLEAVGWIIGTAPDFHLPKQYIPRFPRYKTTYTKVTAIGLAEYECAMLLDADALVVDDIRELMKCKVFSQEQHRVAATLDYFRHSWYYFNTGSILWRTGVEEMNRVFQLSRDGKFMKRFSSDQEFLNHVYPDRMNKRLNNDIVAGKLDEANNGAVVALSWDYNAQTHVEVENTNFWKRHRSAVKVLHFTEKKGWQCEERYNDPIPWEEMPHPCDKKNAICFCREAHLYWRAFRDAKDRGKIITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU68</accession>
    <name>A0AAD2PU68_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU68"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="462" mass="52037" checksum="DD6FA881123EC3CD" modified="2024-05-29" version="1">MEYRYEGNEGEMVPLSAQQLTFSTGVQELPDNLCNGRGLLDKVTLPEGLIKIGIAVFAYCTRLSEIKICYTVESLGKAAFICCNQLTKVDLECSSSSPHHGLKTIGAFVFSSCRSLERIKIPSSVNALGKSVFDGCNILLEAILSTTSITKIPISGFADCPFLQTVSLPNSMESVGCKAFYQCFSLITVIVPLDSKPIEIGPESFYRCVFLANLVLPEGSNADEASFVQCTLLEDRFGEKADDIVHGLVHRFDNFPVQKIAYYNSCTTAEELRQCVEKLDKKESPLVDDFGMTPFHILFSSPEPSQDLFEILLDKFPHYVLGWKDANDNTAMEYLLNNWTRENKALLEDALQSWMYNRLDCWRSDDWRIRFLPTMNALLAQEDRVIRMSWFGIAWSALKHFENVESLSILEMALWKWQNKGERNNDGTKRRALDRDQCRSICGADVVIPNVEAFLGIIPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUI0</accession>
    <name>A0AAD2PUI0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUI0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="201" mass="22877" checksum="302810779F7347D5" modified="2024-05-29" version="1">MGGSSSLNEVMTYNALAQGYNQVDQDEFRAFMSIKNNMPEIPHEDLMKEGETKYNNLVSEGLWHLPSQKQQIMSLSASQAKDKREIIKDYTAKIQKFGSKRKQPPTDPKQSKKPKADGRKDKDNGDFDTWLVTPPKAGDEDKIIKKANKSGSMREWNWCKHHKKMVLAVSRDGRKHNSKTCSGVGTPIKKPSTKEQKRLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUM3</accession>
    <name>A0AAD2PUM3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="364" mass="40029" checksum="4C29A1FE888B27DE" modified="2024-05-29" version="1">MAEDSIDDVIRTTNRARPSLLARPSITEGDFANVVGRPSIANAIQGSLRDINGALDELTVTPGSGSGSAGRRKKSGWRPSLKKQISNKLGIVSMDEMDGIGEDDVYDRSQRYGDDDDNSDLDLDGASLGLLQKELDGAMSEYTGSQGATSKDDSSDPSVIEGEFDNGFENYSVEDEDDYELPEANDPNNFIDVGDKPAGDGSEKNKKQGAAAPSESEPSAVRNSIPGEISIDTSPSVPTLKSAQEPLKETEKENTKNGSKPKMEEKNVSDQEYELGMQQVKYRALQEKMATSQAQSERMLTEQSEELETEKKAKSLVELQLLKLQQDYDRLSKEKEELYKVNKVQQKAILSLMSKLNTKTKRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUU8</accession>
    <name>A0AAD2PUU8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001809">
        <property type="protein sequence ID" value="CAJ1952626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUU8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="357" mass="40213" checksum="7E7A5DB6C6A7F87A" modified="2024-05-29" version="1">MAGSSSGGKSDAGRDVHVTKRKQAEVNESDIRPFQCQEHLGDAAAKSPDNDMLLATSDVSKNGKVSTTLTAAKVPVSSQEEDDLAVVVAKCWNDFLSAEFSLGITYSGLPLSLNYGKYQELLSGQGNFVPKVNKALFVMFPEDYKNKCAKDLLIPVSNAEDYPCPIVIQVWLLTPPFLIYRLNWLKMKNLGEELDWIYWTGNKELKAVGGKKGVEGLGKILHRIKAIEKSGKGAAIDFFKDKKAKDTSKKVCLAEDLHHFWKPKENKRKRVNNIGLSAEQKQQIKNEELNTICYHEQPNQHMEIFEERLMQLELLLQAKKPNENNSKIISCVNKATQDYQKEIKKQYCNVDQGTLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV11</accession>
    <name>A0AAD2PV11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV11"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042200949" evidence="2">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="214" mass="23887" checksum="136F743910B1B517" modified="2024-05-29" version="1">MKLSAITALLAVGLFMDGSLAFQSQSLSQQQQRSTSLYGYVPSGFTPEQYKKFKEQEAKKKAKKKNLGSMGPKGFQSRSFQSFQEALERGEATHLMPVMNAEARVKSGELKREDIPYMQRGGKWDNSDVRGAKREKWLKSDKDYSEGGFRKEQSISIFGYGEGLDWTGSRGRTGPSESIPGAAPKFGKNYKPPTVSQLKGKSDDKPKKKFFGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVM5</accession>
    <name>A0AAD2PVM5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001906">
        <property type="protein sequence ID" value="CAJ1956196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="110" mass="12727" checksum="7C81E43E33EBDFFB" modified="2024-05-29" version="1">MARAIESSKDQNKKRGSVVRIDPATLTRMVKHILSFSQALSWGTKELRQNGKTETITFPRLTRTHPVEVMFMDYARKEAELKGIEFNEERQPPQCTTYYLLVKHLTSKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXV5</accession>
    <name>A0AAD2PXV5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23182</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001079">
        <property type="protein sequence ID" value="CAJ1941806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002380">
        <property type="protein sequence ID" value="CAJ1968321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXV5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="560" mass="62457" checksum="BE6BD6A6F7DE7BBA" modified="2024-05-29" version="1">MSSIEVGCTSCDGVGETVVTPDAGKVPTVDTRFFNTGDGHEGAPAPQVTPNEETAQPSASFKNYIDDDIEGEMSTSADTSKARMASFAEAFLKSLPWRPVKTAGRKRKPHPFESHLVNEYQEQSLKETMCRTYPNLKNQFHMKGIGYYPLCIRLFLCALGYLLCGLPSDYNVDPWELLATAFCKDCSSKEMKDACTRAIKEFLSLHSSNNNSIETTELMRTFMQKCTLSAKCRPKSESKQPDPLPQYLNDVYSKSDPFFKCVFGQKPKPSKWDINMQMFLFAIDALCSRSTKREFAIRSVAGCSDNQLRKLKPGPLLRAIPDIVPTNVSESAKLLIEVKTDDTLPRAIQDLVPANDSESGELLIETKSPAALLIGIQDIVPSNNSESGDSGISWIEEENAPEVAVDLSPEETMHKEDKLVVEIFCKRLAMDKNDRSSIINELCHLITSKTLEESKTSQEQISKLSFKNTKNRVIEKHYALLSQPAKDFTALTQSAKNKKANHMKNIVACLVGSDIAQQQALLKLVYRKFEDLILLHKEDFKWTEAQLALLLSIVDSANIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY57</accession>
    <name>A0AAD2PY57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002402">
        <property type="protein sequence ID" value="CAJ1968708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY57"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="251" mass="28560" checksum="551A0AC0FD194736" modified="2024-05-29" version="1">MTRNYRYKSKPSIHDSRLGPYDILCGRTSHAYNNVGNRRFRVTIRMYLLRYQRLQLRADRKIFIFYLTKLFREEIGFRFLKMEAGDFHDIGEVETRKKIGHALLDQTVKHPIQEATPTPAASSCSPPVLLRKVTDVQKKKPLRSILKAPPVSIQSQLMGSSSSLASSSSSSMTEDQQVRRVSLPLSEPSPYHKILPMPSRVQGVSKKTIATYPPPMKTKQCVTKLESEICMLLVGMNKQNDLPPNQQRCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CA22</accession>
    <name>A0AAD2CA22_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1893620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CA22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1893620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29418" checksum="182B574F84236D0F" modified="2024-05-29" version="1">MSLRLVNLVKLADRGLIRCRRRFSVAPTVLEADASFVDTRFAPSDFTPDVSVVYPNVLTEDEANLILDDVKGRLRRRRYEKGHWDAVITNYKEVELSDLNFENPEIPNIFRRIRQQLATNHLLKDGKDENRTIEWLPCHAIDLKKEGELNAHVDSVKFSGDLVAGVSLMSSSIMRLIPHMDGEGGNVNEESTVEGENKGWVDLYLPPLSLYALTGVGRYRYAHELLPTNSTFTQPDGTEILAERDHRISIIFRDAKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBD5</accession>
    <name>A0AAD2CBD5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TBC1 domain family member 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1904625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039755">
        <property type="entry name" value="TBC1D23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297:SF5">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="634"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1904625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1130" mass="126417" checksum="5D1B9026B446E984" modified="2024-05-29" version="1">MMTADGDTDDEGVMTFDDEDDDELANLFSFGIEASESMASTEKENEEYKKLMQRVLPASVTDDDDSNYSDDSLIQLMEQNKDASAFDPLAVTEQSAEANKDENALTEEDDLEIVDMQEILDWLDNDEELLQAQHEDIVLVEPPEEEPLEQMLPKVANVPATPTFETLEQAVKSPKSTIAQIRDLVVKQGFVVDRSIRPHLWCKVICGKTLDETIKSSVADSFQQWEKQWLKRKEEIKKEQEEKETRQVEEKVAQEEQKINHVEENVREGKKAKEQDDSKPSAEEKELDGEEEDVQSQQQEPAQQPQEEPEQDWIEEVSDALADRIVSALHVDKKSSREALISILHNHYDDGAPTNKNQTTEQNKSEQKAKDDQNDETKNANGNSTENPNDSDEKMDDNNGKKGKNKVEIHDPLLPPVACAILSAGIPKVAASVMLSKIVPNFMPILGLTHKERMKAANGLHSQFHLLVCYHFPCLAIHLDRYIPDWYKGAPVGLVPQSWLVSHLAGECGGTFMSPRRLHCLWDLVLTSSNNSLRFFLSMALLQSHAERLVLLTGDELQVETKKVLSLDDNTTSDAQSEEILNQQAVQWVHDWSDKAQALWEATPLCIVRQLKRLEDDAVNNALLQRQHDIEKRLQARLDAEARAQQEIVEAEREKKADEARLRLTRARLVAYYRQYNPEKEGNIDKLMELYTGRYEVLDKKLKTKYGVGFNPPMKPTSPTKRSDNAGGGGGGGFGDLFGKKQDKDNDGDDSLQLRNLVMEVQVNEAVSGVCWSKSAHRSKVLNIKEASKLEHDRDGLLPLKFCVVDSRPKEVAESQGRFPTSINLGPETFLDPDSLAKQIEMLESLRGMAHLCIMGEGYSALPELYGHRMTKRLSACIGEDNARNRNCALFLLKRGLPFVSIVNGGFATMHAFLSREGPGINLEPQLVLADYNPELSVFGQFETVYSSSGRQKAQRKLQNLFDTSMAAMTLNTMRLEKAVSPEAANDSQTPNSEQNLVSRFFGRGEQPSTVEKGGSGPKPEAEKSNEAADSSKPLFGGFSVNFNELKGKKDEESLLSRNPFSMFGNSNDKKKQAEKGGMAGHFAGFKNKMEKMKEEVLNEGKQEKPKKPVQATVVAIPTAPKDTSKSGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCL6</accession>
    <name>A0AAD2CCL6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1898463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCL6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042157960" description="Enoyl reductase (ER) domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="248"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1898463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="573" mass="61823" checksum="031A4F61CAB6B7C5" modified="2024-05-29" version="1">MRSLLALSTVLILSSRAYAFEAASPNNRRDFLASLSTAAVSLALSPNTASAVEVGGKLKYGDESIMTQKGHGTSANPVQSNLLYGVSEKLADKICSYNRQFAEFAGYFRSTNFEDVVLASKGPVTFYDSVTGKPLFMAPINRSAEDFIQESEVHGWPSFRDDEVVWENVRILKNSGETVSADGTHLGHNLPDRKGNRYCINLFDPNSLKEKMLSNFGRSRLSSSVNVIRRAFSAIPETMKAAVVREVGDADALKVETDFPTPKMGPGQVIVKNEFAGINFIDTYHRKGLYPRDLPFIGGQEGGGTVAAVSDEAAAEGIKIGDRVAYSVFGSYAEFTAVPAAKLLPVPDAVGLDVATSCVVQGMTAHYLTSSAHADLIKEGEWCLIHGVGGGTCQWAAQMAKLRGFKVIGTVSKGKASIAEGLGCDELIVLDEVPGMSFEDYESFDIVERVKEVTGGEGVKCVIDGIGKSTMDISIDSLARRGIFISFGNASGAVPAFPVLRLIGKSAYVTRPKLLDYTVNREELVWRAGEIFGWLQEGKLNVSVDTEFPLEEAAEGHKYLEAGKSKGKVLYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCQ5</accession>
    <name>A0AAD2CCQ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1926492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="262" mass="28806" checksum="660AF2F9F5FB3514" modified="2024-05-29" version="1">MKAPSRIAKSVVITNLVNSIRDSSTQPHGGFVRFDTSCGLWYEVGEKVARDKVGQALRDAARLQDEKQKSRTVDLSPSLSSHCQQDGQCQVVAEPNIFELEEEVSGGENNDVSMGKHSSRHSAIKWAHTEYIGKFSPASPTTSNNEDTHPRAGKNRSFWFRRNALQMPAYNSSNEVTTAFAESADEDITSIDDHDQQQHRQHQQQELAPGASSTMLFSSDDDVLLPSSLPSLPSSPALPSSSLGGILETADFLLEWFENDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCZ4</accession>
    <name>A0AAD2CCZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000030">
        <property type="protein sequence ID" value="CAJ1928026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="130" mass="14333" checksum="A1890167667BB795" modified="2024-05-29" version="1" fragment="single">MYDGDEEDDGQQADLGLTKTAGHGEETWNTNFYIYRGAHTLATIPGPTHVMVDISVNHIPNNAFFQQDSLMSVALPRDLHQIGDQAFSQCHSLLAMTLSLHLESIGRLAFAECTSLTHIDFAPDSQLKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDL0</accession>
    <name>A0AAD2CDL0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000091">
        <property type="protein sequence ID" value="CAJ1929686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDL0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="244" mass="27848" checksum="1FA41F655340DFC0" modified="2024-05-29" version="1">MGRSSSGGGRGRVTPQKVKSNSSSTVVKHLFSTKDENDGKARLLYKDAKERVIDYIQASGMKCSEDMVKSIRDGKSIDFNAIAPRLNAPTQTEAVARETEMAQNKIFYSAKLDENMRRSAYFETNKRTVKSNIMLKFVTKAMDIKLQGEADFMTTLEDLIKLLKRIEQFMKKSADAEYDFLDFWEANQKFFAMKHVTTENFMHFKERFLRQAEVLQDLYGMARFQNFAVKTKAYAAIASTNTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGU7</accession>
    <name>A0AAD2CGU7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS3774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S41A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGU7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.44">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32060:SF22">
        <property type="entry name" value="CARBOXYL-TERMINAL-PROCESSING PEPTIDASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32060">
        <property type="entry name" value="TAIL-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042296473" description="PDZ domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="199"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1934434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="531" mass="57843" checksum="9B927ACBD4F30DD1" modified="2024-05-29" version="1">MRKAVHFKILILCVCHFAASTLALQPAVPIQPVGLARHHQKQSSSTARWAQWKDNRMEETSQVCSSPNPLVKLLRDGPAVVFASMIIFFSAASPSSVVPNMSSMAWAETETTTTTVTTESKLLEPSSITKESSVIEEVWNLINKYYIERSFNHQDWNAVKQKYVDPNAKVDNEKAMKLTTEMVQSLGDKYTRILDTQQYAAIQKYDLIGVGVTLMPNPQKEIIVGGPPIEGSQAAKVGLLPGDYITAVNGLPTSGRTAFDIIDQISEAPNSKTVTFTVRRQGDKDLAGEGSKFDVTMERQTMQVKDPVQYKLSEQRKDGTNVGYIRVSEFNSLVNAKLQDALQDLKAQGANAYVLDLRSNTGGAFQSAVEISGLFFEDRVATYVLDSNNVELPFRTTTGKVAIDPEAPMVVWIDGMSASASEVLAGSLHDNCRAVTMGDQSFGKGLIQAVYGLKNGAGLVLTVARYVTPNGTDIQGTGITPDIKGEMPAPVQIPVLSSNTAKVDFNDIRQKLDPSMCAIPQDRVQAQTAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHE9</accession>
    <name>A0AAD2CHE9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000225">
        <property type="protein sequence ID" value="CAJ1932954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHE9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042057538" evidence="1">
        <location>
            <begin position="26"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="447" mass="48767" checksum="2EEDB38386172623" modified="2024-05-29" version="1">MFRTSLCYVLFISHIAASLLTGCHGLANDNGNKNNVISKDNLPPPPNRLQPNDQQAKMLEKMGYRWNGQKWARGDADSYLRRKASARSSNRYINFVDETTGLPDATSSAVFAAKRMNQVLLQARQKTMTSTKESLARDRDLKNLVQKKAAPFVLFASEVLLFGILSKSGNIDWNHQVQLLRDNPLGVAPLSFAIGLAVSYSRAVSRSMLPGVEEPSGLLSRVFSDVIAEKDPVALPTPSHVRYPNLKWRIGAFLGESLSAVNVALLLQGIVQPNLARTLIHLDNSSAFYEGPRTFAIILATILTALPSSVFSINSSSSPWDGIPAEVEALKLSNATIRAYFNMQRLPEDASADESTECFSTLAESWISKYDGVTDGAEWKVPLLAFAGSLAYATACTTSQIFVDQGDNVLAVPILARIVAAADTYLIRDEEESCQIKVPLPTPATTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHL3</accession>
    <name>A0AAD2CHL3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHL3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="352" mass="39740" checksum="7FCC2E3AD8B4D6D2" modified="2024-05-29" version="1">MQNNEECPQSIIWDAVLFRDWNLVKEECSKCPLNVGYVDGDYDETPLHLAIQNDAPLDVITAIVDAFPGSVRTSSRANRDLPLHLACRYQVKAEILKVLTSRDPATALCETKLGKKPIKILWEKAGAETKITPELWSRVTVMLSAVAKARRQCETQSDEDEKFLLHAAVSLGARSCPSTIIRNLLHGNPKLTGASQRDWSHRLPLHIAVGPTSWSNETRRKYKPRERVFISLLLEAHPKGAYEQETQSNRYPLHLALSNRHCWSEGVSDLMRAAPEVLLLPDPVTKLFPFQLAAIPVGDTCVDLDTVFRLLRSQPNVLGFFEPRQYHQVQGRSLATNWGIYNFPGYIQSFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHU7</accession>
    <name>A0AAD2CHU7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000289">
        <property type="protein sequence ID" value="CAJ1933621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHU7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="141" mass="15883" checksum="6770A2EEC2023326" modified="2024-05-29" version="1" fragment="single">MQMDNRSGGTRSLPSARPLRAQKHRGSLVMNVEVDNWAVAYRHQLEASNQLIAPNSRFFTELAALYIGGVKQSRLDPDYIQELVALPALRKRWHEKLTVTPEAESETDWPSLARAMRSLPAGVQRWTTKHVVGMCGVGKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI86</accession>
    <name>A0AAD2CI86_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000308">
        <property type="protein sequence ID" value="CAJ1933854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI86"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="442" mass="50159" checksum="5588D8BC76A3F728" modified="2024-05-29" version="1" fragment="single">MTFLSPSFKKGLLLKPFKKRGQSKKNHFKEDLESSINKDLSSSSSSSSLSIGTIEKDHDDDSSLEDPGNDEVVLDAEQLQLQQQAEAEVQPNVEYSSVLVENHHLDDQPVETELVLTTTTTYTHSNDFDEEQLFRMQLQSQEDEEEEEEEGSSIAQYYTSVQCPSLDVTSDDTEVILNTNNVSRFLARCTSVQSSSPSSSSLDEVNTTEVILNTQDVSRCTSVLIEEEGHNHHNNYKPSGTEMVLTKARMMVMMIESTTTTPTPTIQEEDHQDKQEEEEASVPEVIPPSEDDFIVVLSDHHPHPHHHHHYQHDHNNNYNNKEEEEEEIKNVQEEPTTMNNTPQDTTTTAIIVDHDHDDDDDNDNVSVSLLSFCNHHMANQHQTEQEKKEEEKASSFMGQESTTTTVPQDIIDHEDNVSVSLLSYHMNANYKNHPVPLQEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK79</accession>
    <name>A0AAD2CK79_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS4498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="613"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="636"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1935161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1543" mass="174233" checksum="39A4EF7FA2213016" modified="2024-05-29" version="1">MDDTAEDMISNEDESSPQQTMGDESEQEEQEEQESSKDEEQVIEFVYESEDQEIPKAIQNTMKKLIVRGPVKTIGKRAFEKCETLEEIDFTEATALETIGKEAFSKCRNLLAFQCPSNVKIIGQMAFDECTNLREIDFSEATALELVGNAAFKECRSLLAFNCPSNLKIIVRFAFMGCENLKEVDFTQAAALETIGEQAFCDCSSLLAFKCPSNVNFIGDMAFQECENLREIDFSEATALEAIGGQAFLKCPCLLAFKCPPSVKTVGRQAFENSFGECERLKEVDFSKATALEMIGEEAFIYCTSLGGTFKCPPSVKTIGYQAFSQCVNLKEADFSNARALDTIEAMAFYQCWDLHSFKCPSNVKTIENQAFERCYRLKEVDLRESTVLETIGEEAFYNCGCLEKFSIPFNVSVVGKNVLKRCNNLISLDVPSANPAIHIRFYTQLGEEQKHLINWDNVVNLYASNPIQRSELVENLGKDITVLEKVRASYIGSIIDGTRRLHSIPERNGWLKFLANNAADEEDPYMIKLCDYLKEKANLKRVRQLADIKDQSARVAKSVAPRHIQKVFEERLFFLGRYDIEKGPPIHQSATCVVVKATDAKMMEYFEEKYKSYEGKEVGKDAFKAILGKVELIPHDDKNINHLFQRADVDKNGIISKKEFVEFCLDEIGCNVVLKFMRNKDQFHREVDRRKNNGLDSKYIVGSIGSHDQEKSDTGLVQSLRNSFLQEDGADTSFLEQDEVSTEYRSVLVMPYGDRNLDTIFRSERPAPIAVRNLMTEIGEALLHLHEKDIVHGDIKMLNAVRTNRRLLLIDLDASTKVGDYIGSKFSSGVLPPEMIHELKTRKELDLYENYVEQGRNSEDEKDKRKVLTTTGQDVRHFVVRSFWEETQEVKSWDEFNERYNAVQTLVPIKKADLPYELLAAHTSLDVWSFGVLLFELITKESLFKVNNEDDITDGDAMRQLHDWNDEDTKSKLKLKVTDAYGRDLLQKILRRDMKDRLTMQQVLAHDYFKPDAVKSESEALSRIEKRAMENQEIIKVNFAQIHKSFGQIHDSLKRVMRYQAAANDLLKLIFKGEKPQPKYFVILPVAEEVNKEKGFSRFITAMKKASMPSSILTTKAMLYFICPLTLQPVVGTDGEAIGYDIDMPQGWIKKYGPAILIGLKVVQVGLAVGRGFGLPLPSLSGAEEGLKETSNLFSEMQGLLVDEMGGDNEEDGLADVLLERFTDRIDSAASAEGPALTKKHLNRIQKSYDGIGLLIKDESFERCGLTMAVSKDETEYVHPEVEQLFEKFGSKCLEMSIEQREKENATLSAVARNTNRDTEHGFSANGDVENKAESAVSVESSACIPEHEMAQQQENLGTKQLQSISADSAVIARLEDVKSKLTTLEDVSLKLSKFEGLNAKIDHMNYAIQNKLQGIPQGSTNVIHKGWLRIQSRRSPFLWNARYVVVYKNGSITHYPNAGSTFLEVKWIDRKDGTIELRSEDKMIAKAKLSARCSSTTTDWLKGNTWNSDYERFATNSSRKAAVASRTDLTGNVIKIETADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKC3</accession>
    <name>A0AAD2CKC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000631">
        <property type="protein sequence ID" value="CAJ1937325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="167" mass="19245" checksum="A0E084A9399A15E8" modified="2024-05-29" version="1">MGIQDQEKWRLVPCGYSQIPGVDFTEHFAPLINDITWRILLVAMVIWKLDAWLIDVETAFQHGEFDGGEQIFMNLPVGYDLMDSSIDMSEDCIELMKTAYGTVQGERQWWKKFVSILKDIGFEGGAADPCLTVRWPLNRTSVGGRERTDSENQKDPERLFELQRLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL21</accession>
    <name>A0AAD2CL21_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000671">
        <property type="protein sequence ID" value="CAJ1938148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL21"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="218" mass="23762" checksum="7B37BEA91F0EF8D2" modified="2024-05-29" version="1">MAASKLQRKEAPRSSARSSNFCECKLEGAFLFLLHSIASFPSYIPLQTMPYQPIWISGVKKNIMGGHHDLCEERTKRKNKNKATQQSNTLLDYTAVSAASAASAASAASAASAASAASAVPQRKKKAPPINIIAGSVGYNTKQLNSMGIDSNFVTDMKRSIGKRMDELERNQKPSWALGRQAPPRMIIATDLILSQFEHRRPQSADSVLPQTKGFLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLN2</accession>
    <name>A0AAD2CLN2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000447">
        <property type="protein sequence ID" value="CAJ1935309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLN2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47821">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47821:SF2">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28037" checksum="EADA7346FE737A97" modified="2024-05-29" version="1">MLQPHRFLPLLAGFQRTVFLQTGKHNPALGMQWRKNTSATFQSSSFNQLETCSGLQNSYYALRHGQSKANVAGVIASDPKIATVEYGLSDLGKEQATNAGQDIVKEYSSKGFEGLLILSSDFLRAMETAECASVAAEIEHDGVVVETRLRERYFGKWDLGSDHHYNDVWIDDAVDPSHTINGVESVQSVVSRTTEMILEWDQKYTGHMIICVAHGDVLQILQSGFSKMDYAKHRSLEHLETATLRKLELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLT6</accession>
    <name>A0AAD2CLT6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS4689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000458">
        <property type="protein sequence ID" value="CAJ1935354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="525"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="781"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="711"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1935354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1154" mass="129924" checksum="9800AD6575E4A301" modified="2024-05-29" version="1">MQPLDNRSLDLDGEDPILVPADLGGKSRLSSHNDSETDESASERRDEVQEIRNRSRHEDRSVQVWRLALLFLILVIGATVSGLTFHFLQQEEKKALNLAYDQFSDALSEAAIRQQEDIREGFQTLATIISDYADASNQIWPFVDLPKFEAYAEHVLKIAGTEVCTLLPLVTRENKEAYLNYTDNNYERIVAEAHMIENGNLDDLNPVGYKSFLTVGTANGFVEDIDRDFYHPMWHFSPPMFTYGALNWNAISVPDYASVFEAVKILKHEPLISKVRPYVTAGLSLSNAEHAAMHSEIEGSSTDFPHSFVFTPVHLESEDTNSPIVAIIGSAMGWDFSLQNLLPEGVVGINAILKNSCGQSFAYEINGPDAFYLGEGDMHQTKYDEYERFVNLALHTHPEFEDTQGHCRYSMHLYLNDKFADLYLTPVPLLYTVCIAGSFAFMIAVFFVYNSFVHKRNETLVANAARSNAVITSLFPDNIRNKIIGDESSDNKKNPRNFHELLDPTSDPLTDLSRPPLADYFATTTVMFADICGFTAWSSVREPSQVFTLLETVYGEFDRLTKHSKVFKVETVGDCYVAATGIPTFRKDHAVLMVKYAHKISRAMTHMTQTLETKLGPDTADLLLRIGIHSGPVTAGVIRGEKARFQLFGDTMNVAARVESKGAAGRIHVSLDTAEHLRKCHKGHWLVKREGTIVARGKGDLQTYWIGKAVGSGKESTGTGSETASVSEKSNNSLEEATPAAFGNQLDDAGDRKDRLVDWNVTVFTDILKQIVARRNAYVAAKKDSADLSAVDLRVVEDMKKDDFKPLHDVRETIWLPEFNQTVEDSQEDAHTIDIPTSVSTQLRDFISTIASLYRSNSFHNFKHASHVTMSVIKLLSRIKAPTDFEMMENENESDDDSFHVKANLHDHTYGITSDPLTQFACAFAALIHDVDHEGVTNAQLVKEGAVVAAKYENRSVAEQNSFVLSWNLFMSDRFATLREHLCATPAEIIRFRELAVNAVMATDIVDKDLKNLRNNRWDKAFKNQANIEELDNESRESINRKATIVIEHLIQASDVSHTMQHWHVYRKWNERLFHEMHAAYVQGRSDSDPALTWYKGEMGFFDFYIIPLAKKLESCGVFGKSSDEFLNYARSNREEWEIRGEEIVAEMVAGLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLZ3</accession>
    <name>A0AAD2CLZ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000480">
        <property type="protein sequence ID" value="CAJ1935497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLZ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="285" mass="30778" checksum="F216AE5691CAAAA7" modified="2024-05-29" version="1">MGDGSTSTSVHFQQPKQRSWNTSQVQVDTNQMEGDTTTAVSSLTAASPGGVHPFFLPSPSSKSGTSGSAKLPSLAGRGAHCSAAGSLEDPGRLLLGHTVQAEDLELVARPVLFPTLHLTNIYILFQQETDSLGDNHRCRSSLATRVTFQNVNGVLEDGDHEKQRQINSWLKDERVGIALLAEAKTYWPSISEGHGWNDRMRQATMKAKQKGFYLAVAYNKQQSRSLATTAFQWGGCIATVLSQVLHRAKEGGSNLTGLGRWAYVCLQGKKLMTGGGMTTPALCLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM20</accession>
    <name>A0AAD2CM20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1939175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17468" checksum="17FE41FFABCBA0F1" modified="2024-05-29" version="1">MHPSTAEAYENLAQAHVNEDKTEDATNAYAKAINIHKTVLGNGHPHTKELMNILHILKCEKTAKAMNEHALAVKAKGDLEKALQLFQEALDVSKKIFGDVHPRTAAVYENISAVQVEQGLLKDGIAASAEALKIRRRAHGDDHTDTKRRIWKRMDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM27</accession>
    <name>A0AAD2CM27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000757">
        <property type="protein sequence ID" value="CAJ1938689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="235" mass="26245" checksum="873BA05A77D39C1E" modified="2024-05-29" version="1">MMLLNKTAGPTTVTESSPAPRTRLMSFKRSNDQASKRIRSRYLHKLGVVDSSSSTSADSTSFSDETCSIGTTIDTTQSSKGSPKQRQLRRLGGRPVEIQFQPLKGSDGEDENHGPSAFAPLQRQRSLSLSENSTSTATSVSFDNYVVVHPIPSRNAYSEDMKQAIWTNAKEEEESMQRNYLEFASEGMIWQNTLEEEDFFVYNNELVHPVHIMSQHCSVNASFLMGMSADRRAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMI6</accession>
    <name>A0AAD2CMI6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000833">
        <property type="protein sequence ID" value="CAJ1939702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="434" mass="49736" checksum="239ED1A120BA9D29" modified="2024-05-29" version="1" fragment="single">TNEDLELRRTTIFNHFLKQVLLLSTQDSSEEEKLTHDDVALLRWMYYQSAGPPGTTKEEARRSYIEEFQKLLDDAQKSIEKRYGEVYKSLESEKEADEFFAIGRELYYTGPKQELTHSTFLRLPDFIRNQNGIQAVRDLKSICLQEILKEEFENKMSAIADKVEGVSFKSAPGVKGFLRSYEKTEEYGNIFSEDVDASMRVVDGLRCSFIVDSLSQNLQVGKLIESTFGVARTKNFHQRGNVRYADRKYNVVFVSDKKVDGVGDPIQVICEVQVLLKEYDAIKADGHLLYEFQREPEQKPPLNLRSSTRDAKNCVCAFGKFWIIFLVTLIIGLFVYFTYAQQIVGCQVNNCRPTCQISNHSLCETCNIGDDCLVADSTWKTVECYYIEDDWDVIDCFCTHPGNTITRCNHFNYNGTRTDAPTTSPSPFPTFPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMS2</accession>
    <name>A0AAD2CMS2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000791">
        <property type="protein sequence ID" value="CAJ1939454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMS2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="154" mass="16959" checksum="C3DD683F7B82DABB" modified="2024-05-29" version="1" fragment="single">AVSEATTVIQLKEQCPSLQGADASAERISVDIITSTNSKDHYELQLEPFPNGLCTLTIISTDQENPYLIPVARSFDDRQWQLAAGPFAASLDLDCPSDASACKILLPPVKNEEIYRLASNTQYTDNPRAHSIRFLERATFGATGDQPVIENFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMU6</accession>
    <name>A0AAD2CMU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS6641</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000813">
        <property type="protein sequence ID" value="CAJ1939564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="535"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="791"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1939564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1172" mass="132046" checksum="7CD8894395ECDA6C" modified="2024-05-29" version="1">MPNRSQSLASNESMRHLDNRSLDLDDDDLMGIPGDLGKSKFMSQSTSETDESASEKRDEVQEIRNRSRKEDRIVRLWRSALLLLILVIGATVSGLTFHFLQEEEHKALNLAYDQFSDALSDAAIRQQQEILEGFRTLATIISDYAATSNQTWPFVDLPKFEAYAEHILKIAGTEAVTYFPIVTKGNQDAYLNYTGNNHERVIKEAHMIENGNLDDLNPVGYKPFFTVGTKDGFVPDIDREVYYPMWQFSPPMFTYGAVNWNAASVPDYADVFEALRTLKSESPISKVRPYVTAGLSLSNEEHAAMHSEIEGSSTAFPHSFVFTPIYLESEDTDSPIVAALASSMGWDFSLQHLLPEGVIGIHAILKNSCGQSFSYEINGPDAFYLGDEDLHQTKYDEYERFVNLALYTHPDFETTQGHCMYSMHLYPDNKFANLYLTPVPLLYTVCIAGSFAFMIAVFFVYNSFVHKRNETLVANAARSNAVITSLFPDNIRNKIIGDESCRKNPRNFHELLDPTSDPLTDLSRPPLADYFATTTVMFADICGFTAWSSVREPSQVFTLLETVYGEFDRLTKHSKVFKVETVGDCYVAATGIPTYRKDHAVLMVKYAHKISRAMTHMTQTLETTLGPDTADLLLRIGIHSGPVTAGVIRGEKARFQLFGDTMNVAARVESKGAAGRIHVSQDTADHLRKCHKGHWLVKREGTIIAKGKGDLQTYWIGKAVQSVKEATGTGSETASVSEKSTSSFEETAPAAFGNHLDDAGNRKDRLVDWNVTVFTDILKQIVARRNAYAAAKKDSNDLSAVDLRVVEDMKKDDLKPLHDVRETIWLPEFDQTVEDSQEDAHTIDIPTSVSTELRDFISTIASLYRSNSFHNFEHASHVTMSVIKLLSRIKAPTDFEMMENENESDDDSFHVKANLHDHTYGITSDPLTQFACAFAALIHDVDHEGVTNAQLVKEGAVVAAKYENRSVAEQNSFVLAWNLFMSDRFATLREHLCATPAEIIRFRELAVNAVMATDIVDKDLKNLRNNRWDKAFKNQGSIEELDNESRESINRKATIVIEHLIQASDVSHTMQHWHVYRKWNERLFHEMHAAYVQGRSDSDPALTWYKGEMGFFDFYIIPLAKKLESCGVFGKSSDEFLNYARSNREEWEIRGEEIVAEMVASLNKRPATNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNG5</accession>
    <name>A0AAD2CNG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS6405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041904770" description="carbonic anhydrase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="841"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="933"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="362"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1939061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113129" checksum="5F939DE6AA7B3BBB" modified="2024-05-29" version="1">MKATGRLLSFPYIVLTAMVCSQNVSADDTDRFNYRETVGNNYGPKDWDKVTCLNMESCQGWPDGYELGVGWELGDKNNCRWCPADGNHTCGVHHQSPIDLLRTAAETGHDTECYDYHWIAYEDGACKWNHMVKNGYTTPSQSFRINRHGLQIVTPVDENTGELQCEGSTGRQFPRLDYPKGFPDWWYLSHTDITVPSEHTQSGKRFAAEVHLSHFYSVEHDTRQVGKVAILLDVEDGAEHRRRWGFLDKLICQWREVEEQTRQECGLESAPPYPGCRNPARQEDEVIPPVNDPYPFINCDTIENHQRICKPTSCCEAERSSTEYCVNDIYGRYGDDMVGSICWWCCPNKLLDREDPPPSLFPISSGPTTTSPTSATPSTTGPTTSSPTAAIAPTTSAPSTHSPSFSEVPTSEVEMTISPSQFPSLEPSLVPSSVPSVLPDDPLIDCEQYDGLPGIDMRRICKDDSCCDPARSATDHCHYVYSLFGDQMAKVCLACCDPPKHIGPPPPPHPTYPEIDCSLVPNPYRMCKPNSCCGPVRSDSQYCTQTYIDFGEVMGSICWYCCSEPKEVDPWVLPPTVEPRPMEGPTGLPTGAPSHEPTSTSTRVSTPTVYPHKSNAPSQSSIFNPQTSSPTTTTLTPSHEPTLHTPWLCSEFDGTNGIDMRRICKDGGCCDPIRSSTDHCHHVYKFFGDAMKDFCSDCCQKELAPPPPVHKVYPPIDCTLVSNPFRICKPTSCCNEERSTTLYCQDVYETYGDAIGSICWYCCSLPKEVGPTGFRRLESDGGTRTKIAHANSVDEIQEKDILLPHGLWTQDLQMDASNFEIADDIEEQHLGSIEAYREKRDAENEEKQEGSLRRLQSSQASGDNYINVPYSPYEWMREVRTEYYFRYEGAQMVPPCFETVHYRVMKDPIRIHPIQLVELERLLAWRIAPKGSGPNECQRDTAGRERPGSNGNAVDLNRPLQDYSNIHRKVFCECIDWESKWTEDQKWCQLDKKTRFFDRPFNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNR9</accession>
    <name>A0AAD2CNR9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000802">
        <property type="protein sequence ID" value="CAJ1939532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="201" mass="22388" checksum="D441888ADB3F09D2" modified="2024-05-29" version="1">MAVNDSNVSSLTSLKSIANSDTTATIITVVHPGDRLVLNYQYPQTVARYTANDCSEFSNETHFGIYGNSYRFQSKEVNKNFTFVCQQENNIHNTTAIMSDDDDDENNNGCNDDGSYTNARTFVVRSVPPPRKRSWPIQNPNRVGVVDHGLIFLMVVGALGLISLAMNCCMDYSDSQKKKAADDIAREIMNDIDNNADDVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ65</accession>
    <name>A0AAD2CQ65_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001002">
        <property type="protein sequence ID" value="CAJ1941411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ65"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="232" mass="25907" checksum="3C4B0846D18CCE6C" modified="2024-05-29" version="1">MPSELSNAITSEQWERVMQICNVKPSAAKTWTTRQGLFEGIKDANVLPIHEALVAGAPYPSIEALIRAYPDSVFCKESSYQRLPLHCACRKNAMQDVVELLLKQYADAALTADNLGRLPLHYALSNGANDDVIDVLLRYKSNSARGFDKRGWTPLHVACGVGASTRVISQILKCYPEAVLMRTTKGSTAKQCLNLTKAANKDEVKKMIKKYYMEVDQQYRLPKQPTSDRDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR49</accession>
    <name>A0AAD2CR49_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001033">
        <property type="protein sequence ID" value="CAJ1941533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR49"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="130" mass="14788" checksum="7CB0D7B063CDC9BA" modified="2024-05-29" version="1">MDVSITRQMVTDQAHHKELIAAMTAMGEEFSLRAVTRDGEPDNEAYEKWSKQQIAKTQFQSLKQALKATYVGLQQGMETPNQQLAKLNMIRYKGGTRTYDSVATLFGRIARILNGFNHENPPPTNQTWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRU3</accession>
    <name>A0AAD2CRU3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000979">
        <property type="protein sequence ID" value="CAJ1940934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRU3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="13404" checksum="E6AF37B533E2CA03" modified="2024-05-29" version="1">MMQVPLGMQLMQIPTQGGGTVTVPYSMNANGEIAFSGMQLSQQGFSGAQVRQGFDATQARTPQVVKTGYYDASNVFHNAIKGKDENGNDVYLIPCPTGTTNVELQADWKNASKSEDLPDLATEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSW5</accession>
    <name>A0AAD2CSW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001347">
        <property type="protein sequence ID" value="CAJ1945317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="135" mass="15150" checksum="626137757BF0014C" modified="2024-05-29" version="1">MLSRAVFSSANRRVWKIANVDALRHLSTSGPPPSVPPKSPYNIEPDTADKSKEEMRLHYRSNEESEFKLGKHRSNALELVEKFPIIEVEGEMAICDGGGGALGHPLEYISLERPGVVERCKYCGLRYASKKWHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT77</accession>
    <name>A0AAD2CT77_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS9355</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="11">
        <location>
            <begin position="82"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="12">
        <location>
            <begin position="395"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1945211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="593" mass="67980" checksum="816DE75CC0F636A4" modified="2024-05-29" version="1">MMDDEEMPDRPPTFDSMFINSIDALQGRQIDQKMNQFPEWNVKPPLFTAFRPKRQRFWQEPIDEDAMHYEEPTLLKGMIRKGIPPPLRCAVWMSNVIQSCNTHQPLKYAHEYRTLAKVRALDSAYDSLYSNTLKKEDVKPMLFGNTTSVSEDSVKEYKGAPALWRCLFALHSVLGVVEYAPMVPALTQVLLSHMGESYAFCCIREMAHHSTWYWPTSKSEHAAYKRAFLDILQKLHPSTYKTMTGHGISDDFAEAIFADFFQTILPEESVLRIMDVYTLEGMKVLFRAGVAFAVLFHRLWKEGACYKSVDCWKTLLEFGRKVNIGVLITKAYGVHGKGVRKRFRFPRRPILQRIIKLEEDRYWRENENAVIEAPNVNPLGLVVPPNDEDHAQPELSQSRAVRCRLAEWLPLSLRYTKLDLIFSTNHHGRTLENFYRESKKAKHTIMLIEPLDAPNTIIGCYASQAWHPSTKVYGDGGCFMFRIVTDESKSKENSKCWKWQYPESSKSFDDDEVSISSTTAILEQYQVGTREYISMGGNAKGGAGLRLNEDLTKGESNKAAGFENEPLSGEDMFEVGLVEVYQFVREMDGVPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTG7</accession>
    <name>A0AAD2CTG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38909">
        <property type="entry name" value="G PROTEIN GAMMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38909:SF1">
        <property type="entry name" value="G PROTEIN GAMMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042086691" description="PDZ domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="801"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="876" mass="95372" checksum="A31113E99650E640" modified="2024-05-29" version="1">MRRTLAPLLVVIPVSMVYGDIQSTNFGVRSLRRHPRNNPSKGRQGILTHSDDGRSKIMTAFFLDIFETQGEIEENSFPVVRLAMNNFLLAEMNAIYEPQNNELDSVSSSLIGYPATIEPSGQINKMGTEMLMEIKMTFDNEPSPDIAELEVVIREVMSDLSLFVTNLTRFEGADFYTVTEAYRREIPTAAPSASLAPSTSPVQKVAVSDVISDVQPPADESALTPEQIAVPAILIGATFLAVILFLLVRRRKRSNPDLSKSGDQILTDIEGGAFSFDKSLDSHRPPSPEFPSSSVSELGSQDSVFSDNIADASKRLKTAPANTSGAASQATVPSSNRMYNLLNFMNENEDLYAPTNGNANPTDGRPLPPAAVFERDGSSSSDTSESHSSSKNSFAEIAAYTARTGAHTTGNGETLVERQAQPPRPGNSRNAFSDIANFTACTSNGGGRDPTPRSTSLERKTQSTSPGGLMGMFHCAPTGGAVEGGRNNQERIGRSPERRIDTGNEAKDIFRPRSRSGTPSKHRSSSQSRNSTPNRSRPSTPTRSRPSTPINDHSRHSSNSPSAGYQRMGNSGAMAPGQGSNGGTRNYARKPAYLPSNDPQSQRHPFQDVNLRTPDVYSEEKKDEGLETPDRKRPVFIEGMTHEIFYPSGGRRHAGNNGVDGSAMYQANAMDPSEWSYKSYDNNSVGNSTISDVVALPKEVSRQRGDTAARNGNATNQEFSPHLEEDTEWIEKRIAAAKQYPTTTPNISIPIQHQHSTDSLSYASNDKDVYNHVNSPSDLYSSKDDSVMSSIVCRDCYAPPGKLNIVIHSTKDGPAVHTVKPGSSLEGHLFPGDLIISVDNVDTRSFTAEHVMKMMAAKSTQERKITVLHFEEESQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTR8</accession>
    <name>A0AAD2CTR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001469">
        <property type="protein sequence ID" value="CAJ1945719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="137" mass="15720" checksum="C8DD1A5F2F245F27" modified="2024-05-29" version="1">MFIGMPFTNDEVIHNGIRLQSKQVHAVVNLFVDPPRPPFPNFDTPIVKWGKTEDTNFYIIPCNRLVAPAIVVPNLLEQQPQGNVANANARRTYKKRRAKLMQEPGNEPLGDGYFVVDNQEQMAQRMEELIDDIMERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU23</accession>
    <name>A0AAD2CU23_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS7569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001035">
        <property type="protein sequence ID" value="CAJ1941563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU23"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="346"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1941563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="496" mass="55693" checksum="E418FE9307E8DE2E" modified="2024-05-29" version="1">MGKKSKRRLNQKSEAKRAAPSEREEEDYEETAENLRFEDPYIDEIEEEEVMDDDGEEEMEDADNQDVELVQSWHPLMGVPNDGPLEMDPSAYKMYHTLSPEWPALSFDFLRDDLGDARQRFPHSMQAAIGTQADRPDNNRLTIMKLSDLSKMPQEEEEDILGDEYDKQDDSSSSDEEENVDLDPIMEHYHVPHYGGVNRLRAMPQQSDIIATWSDVGTVNLFNVESIRSRFLASEGRSMRDSSAGCQKPFFSHSGHGAEGYAMDWSLVKKGHFASGDNDGKIHYWTPRPEGGYEVVPSYESQGGEAVEDIQWSPTEGTVFATAECGGHISIYDTRAPNRAMLRPCVHENKSDVNVTSWNKLVSNLLATGGDDGTLSVWDLRNFSQQNDKAMAPLARFTCHQTPITSVEWHPTDESMLAASDTVGAYIYDLSVEEDLEDANKASSTTKTLVADIPPQLLFCHSGSQEFRELHWHPQISSCIMTTALTGFSVFIPSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU73</accession>
    <name>A0AAD2CU73_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001309">
        <property type="protein sequence ID" value="CAJ1945022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU73"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="359" mass="39287" checksum="C415D0EBF579A92F" modified="2024-05-29" version="1" fragment="single">MLNKRNPLHSRKMEKIASAVDTGSRGLISKAASARKFSKDVLKGSNHEKKYEEDAIMRMNEDDSDDDFRWSVRPGIINSNKLSSAGAYEDDYNDDDSISDEEEEEGDLMKERGISNGKSSQNSSLEMVVGPSSAHSAQSLGLGTISEDDDDDGFATGSAGGGSVGGKKKKKKKKRGTSPKRGTSPKRKMKRTQSEKTSSKSKSTISETTEARMGGLSRSKSYSNDDDLDDDDLEVPRRTIKKSKSKKVKKGRAIKAPMKIDFTGQVTDAANDDDEPSEDFDDSVEGDTSSPTKTAANDNDDDGSDAYMDPIARANIIAEHLSRRSLNSRSDNNNHLEEIKEKQPLEEVNNQSKLESLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUT7</accession>
    <name>A0AAD2CUT7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001180">
        <property type="protein sequence ID" value="CAJ1944017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUT7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="114834" checksum="4818AB00BDFD9FCF" modified="2024-05-29" version="1">MSQLLVQCFEITGTHADVFRSLLQVSDPVRIGLLLNYPMGIGRAALERELMRHFTFKRAIALEPAWPQNPAFDRSAWLAAMDAELNQGPAGLFQMILPGPIDGFYVFVVRQKFASLAQEVLKNLAAFLISHLELWQDLKYQRKTCRTWLCLDHYNRTIARLEGRPLPLPTPALKSTPQSATNPPTESPARAKLSASEQRSRHARLRSLTVGRGQNLRNQHTSSQVAHSLLDAYLNSLPPGNYFSDDSHQKSPRVTRYLFQNVQGLPFPMTHEKQKGHFKRWTDERVGIALLAEVNLQWSAVPIGHKWFDRVKTFTYQGHFSSVSYYKHQEIPTPSAHQWGGCSATLLHKVVRHAKSGGKDESGLGRFSWIKIWGRDIRQQESQTDGPPAGPLDLVVVSAYRPNKEGTNAGCVWNYQQNHWLSKGVTMDPRDKLTLDLVDLIKQWKAEGCKILLGLDANEDVSYNSPSSFRQEMRSEGLTEAILRRHQGPYPATTQSRTTDTPIDGIFVTNGVRVTAGGYLDFQQYFKSDHRGLWTLGAPPVTSPSFQPRRLTLADGRSVDRYIKAAEAGYWHFRLPQRLTQLAEDILVRDGYLTANQQAQFNTIHCQAYEICRRAERNCRKLSMDKAKWYLEHQAYKEAKRKRAHQWRLEYLENRSAAVRRAKKGNIKARIRLKSSGWHKKEETRWRRKAQGKGFSGGLQQIKVTQVAQDGTSHWVTCQSKRLVEEGCMQENRLRCDQTRYPYPTPPMTAHLYSNFNGPNAKRNSQALLRGLYETADPYLVSFLDHCRRAEGLEDQPLEVDLEDHVSFWQTRQDSGGPHAHNPNDEFRAAGQQQESGEIGHCLCRAAQLDPKRTTWAIDLALTKRLTWDDLLHLQRRPAGWISNDATSCFDQIVHWVAIISLMRFGIQWRTLRSMFDTLMKSKQRVRTGFGNSDRVFTPPTLIPFQGYGQGNGARPPIWVAISSIRLGMMIRKGFGFDFLMSISWALLLADCFCFVDDTDICPAALPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUX6</accession>
    <name>A0AAD2CUX6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="572"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="899"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1458" mass="165759" checksum="4B6756065EB23604" modified="2024-05-29" version="1">MGVVVSEPASTTNCEFANAELTDADSEESDLLKIPTTATNTPTFVTMDWIPGFEASRRKRTPETGSRMQIRPPTPTRASTPTRNGGGASTPTRNGARSPTNSAYIQTNPSKKAPVVTRSKGVRFAADTRQGREPSPTSRSSTSETFEQALTVLDAIVDRDEQRNAGNSGRVRMAASPTRAASSPIRGGNSPRRAGNGREDPPQFELTEANEMNRILTEQLRMLQRKVNKLQKNGNVAVDDPEVELMAKRYNTMKKKLASVTAVLEEVTMTNRTLLTKNEELKRRIRGNDAPSRSEQAVEDQDRDELIATIRSLEAKVEDYKEEKMSTKATQSRKDAKFKDLENSLADATYENSQLNAQNTALELELVATKDKLENAEESFKKSEKEKQKQTRQISDLFEDLEQMTETNEKLASQISVEKTYKHEKSHQKEAQANFMEDIRDRKEALQQKVDQLNSRLGDAVKTAKEFEDMPQQVEEMKRKIEIQEVSHRSEVSLMQTEMSKLKTINSALEIEVAGLNVRLDGAHKEINVTRNAKNEIYEEFRMKQQSELVTKNEREAMAKTNEPKSADHTLFNNMDDHMNELERLNRRLENEKDGIQQKYLKCCAEYDEVNEANRKLATKNKELTEANLELEKIATHSKGTVNGKSAMISALARKIEELQYQRTELMDERTTLETQITVEKNAMIMANTNISELEARIAAYESEVSELNIEIQELNEENERLQKFESQTYEKREELKQKRQMIESLETKIEELENEKNAMEEKVDRAEAEVEAHKNTIAAASKQMADLGGSNARQESKIAELNEQLEASKRTLEAMMKTHEEYIEDQRKSDVEKLASWEEKLSDANSEWQEALDDIINEWQIKYEDANDLWQAKFDSSAKENALLTEKCATMKNVYDSKNRANKAWEELQGKLDQSEAKLAEAKEDNNELTKTNQELEKQVNAQVEQIKRLNEYSVTAAKKQNERMTELKERTMILQEKCVRLENRNADLQAKDEASRIEVNSLAARYKCTAIEVEQMENQFTTLSKEIVSNRHNNSNAAMTSIIAALNKQVEHFKKERRQLYESQATIEAKATVHRNAMVAATSQIAGIEAEKEALQDQLKDLKVKLNDSKEEIETAHQTVAVAQSTLTSLGNIDKERQAKIDDIRELNKNLAQKNITLSDELSNLQTAHSELQSKYDLCSSDLEALKVRVNTQETVKRSSVAMASTQVAELSARNSSLERSLATAKEELQEAHADMEGAREEMESTMSQYRSKLNAMTQLNVECQAKIYELEQTIDKNDYVADPSELKATLATCQQQLQDQTQSNEVYKNLIDQLTQMNDDLKAQVSSHKDSLESMKESEANMSAQEAKLSQMTDELATLTQENSDMKDTLKALTNKLTTVTKDRENARDEGKYLLARIDEVSTAKDKVDKTLKDWKRVSKGKMRELTFRNTQLTSSNQEKANEIDRLRNLISRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVS0</accession>
    <name>A0AAD2CVS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Bulb-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS8450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 99 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16317">
        <property type="entry name" value="Glyco_hydro_99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042271894" description="Bulb-type lectin domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1943457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="77839" checksum="E9EF72C29078FBC0" modified="2024-05-29" version="1">MRLSSNTVLLSLLTFICCHNDDGSNFAEASKLRRGSAKRNEEIEDISSSPIPEDSSATETTRSLLSYYSTLTDAEILALKKTPPSLQSSKCGNSMFRKQHPGCKTIEEALTKAPSEPLFSSPTASPTQPLTTTNGPTDVPSQSPPPKPTREPSTQPSTRPSTRPSTQPSISPSTMAPSTSFPTESPTRVQDRPLNCIQTVKGNELTIRSGINFRKGDVHCLISDNGDDGDSEAETYFGYTWTNQFGLFSNNTSVWTVPSAIVSSFDRWTFQDDGNLVLRDGSGKSIWTARTHGNRGAKLKVSVEQVWIESNDNVGSTVWSQPPYIATLAPFTGEYPDPSTGLQYYAYYYPWYLRDNWSRHGYQDEPLLGKYGTDEVAVAEQHIEWALQTGISSWIISYWGPDHLTMKHFKAGMMNAPSLNKINFCMLYESVILDDRGNWRDGSKEEALYRDLKVIVDEFFDHPSYLKINGRPVIIFYITRSRMAYDEGFDGPSVIANMRRRLGHDIYFIADEPFFDWDNKSPEDNGNAFKDGKQVFDAYTTYNMFRNSVVRQGETATDYQMREAMPIWKRWAEQLPLFPNVMPQYYDFRGHKPLLGNSADFMKQLREVACLPQTNFDGAPHIMMITSFNEWWEGTQIEPEDGSPDNWNNYGFQFMETLATFKKEMDSLGAYWCPEDTIVEEADNGKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWN1</accession>
    <name>A0AAD2CWN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sugar transporter SWEET1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS10074</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000004">
        <property type="entry name" value="Sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1945932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="322" mass="34605" checksum="98334442E211D5CE" modified="2024-05-29" version="1">MSSTQEIILEYVCPALGVVIANIMFAAPVRDLKAAIAKGELGTLNPTPWAFMLGNCVGWMIYGTLLKNVWILMGNGPGLLIAIWLNLGAIKLLYRGHYATDMRDTTERTLTASSLDLEQPAPVGGDMASIASDETKNTILVDELSATTPAPTGQENLLMLMCTVWVVFGTVLALADFMDLNSKVLMVGIVTNCILIVFYGAPLSTISQVLKDRHTASIHVPTMILNSLGSSFWCVYGIAISDYFIAGPNALGFVFGAVQIFLYMVFPRSPSAEGNTTDLEAKADLVLDFGTAERAEQVASSNLVQPHLQDVMEDYGTVAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBV6</accession>
    <name>A0AAD2FBV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS30</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1889363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1889363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="341" mass="37983" checksum="5F2C1246E085958A" modified="2024-05-29" version="1">MDARLLIKSKSGQMKQSRSLVVLNSKALEPHHSSPNAKWERDDDSNVYHRHRSKVKQNMQTSLNAALKSEDPKLYSWVTNPMQQAGRNRSKERRNKTSSGDRKNSVRSPGARRLRKVFSFNSKQKASKRDSSSNDLTSSTWHGDGSPTTSKHSGHGGARRMLKGKSKSFRQDPNASRFTLEEQNVCRESSLNIPLHLKAVCKQPARSSPRTVQRSTSARISKSKNSAPTSPTLQRSTSARVSSPTTTKVPSEQLPSQLSPKLKRSTSARMPSSNGPTSPTLERARSARLSRRGRRRSIHDDHGEGIFNDINREKGYIASFLGSSDHSSQQSNFEHSNGMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCA0</accession>
    <name>A0AAD2FCA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1908376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1930"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2179"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2230"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2892"/>
            <end position="2939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2202"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2234"/>
            <end position="2251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2262"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2892"/>
            <end position="2915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1908376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2939" mass="330368" checksum="2CA746924A221FDA" modified="2024-05-29" version="1">MDPHVKSINTDKRSNKRIKFASAKQRAKRASADVYRSYKRKLGATSAATREEFVHNIQGTSQAKKRHRTRHAPLEDSNRSAIVKLAYTDDDAGDEPEIELDVSSTFAEELDVAIDRNASEVFGKFHRAVWKLVRSLPEVLHNSQKIVEILLSYMLSPASLPERPCQMSDWQNQSLRKEFVINHATTDILHLLSVLARDLRHEIHPFLHEQILPRIIYDLLNPPPPPPDSGKQPIPLDVTIVEAGFRTIGYILRYDSEVMKDDLESMRKYYGATIANRREIIRRLATETFAPLIRKIKSKSSRQKHLKRVLKALASAERQPLTHQLKRTQSDAVDGISMLAFQVTKGVPGRLHSKGFQTLKYVFNLGTSDGTNGRLVLSVLSTLLERLCHQMNQETISMITQELIGLVKRSITLYLSDNENGERYSFTPVLNSVKLLEQTASFRSGNSLKGQQKEVRSDLFDSLESLCRAQLFRSLDADVKCEFVRRFCPPLKVLQSHPETASWLRKFLSELLKHDSSDSRENASLVCSMADILSKDLMSEVVEQSVFSAVAQALLQAAAAVSAHHPDSALLITFSVASRGMAANENEDADSISGGSTCVEAQLFAKGGDWCTVASSEKQKLVSNSLVELQGEKLSRELVARLVMALRCIPFVTLISLENEESDVQKKHFKRASNWLLETLDCLEKTSVNEGLERVVTIAKSIALESLTHLALGFWQISPAVEKAVLRAKPIAERLLSEQSGSMWAIRGVAVYARALSKTDKCLKNDLDKTFDALVPNLRSQSHSLRLHTLEILNTFPEKHFVTDHSDLDLTGDLDEDPGFQHAAASAKSGPSGPCDILKTMCRLEKIPIILANERAISALISRIEVLGRSGKLPVVYAEAVSNYMIGSFYVKFAPVWPEATRCLTSLLKGHEKNCWPALEAKLRTSMERSPQRDDNDQDDHISRSLFSFDGHLYNCEEWQSSNGTNVSIFGNSDSIEDLGTARHQITDEDTATENIWGVAAESQHLVGKNSRVIIPVFLAFLHNQYFGFHINDPDARELELKEHVPSDDFMTYSKIDKGIVYRRLLCFLKVFAVLDGPKQLVHHQLLERIFRCFLNHQDETVARLALTALSKYKVPYLVPYQSFFFDVLKKGQLKDSLLDFAEKYKEGKVVKSHRAQLMPLLVRLLFGRLSPKGKKSSKDTPASRRTAVLSFLSVLCEGEEDVFNFVFMMTRSFIPRNEKLVAMEQITPEDRENIMGVLMSIRPQDLVTLPSGVIEGFLHLLETVLTQLGHRISSYVPQFASIVLALCKMAGDGRQKGEENGKEEEAMSSMASHTPHINRYSSIRSLGCKRLSEIYGRFGDMIEVQKFGPLTWEALNRSVYLLPEMTVKTEKAPAILELLEVMSSDCRTIEMLAMHEAAVESVVKCIAETSMFSVMNSALSIVENLLTVDEPSSGAKESTGIRLIRKFVPLLMECFTARLERGGGQLAESKPERGKYKSKGGNRQNTWKRELEILCRVSELLSNDDGCLKDRSSILATLFSLLLPYLEPDRMTTDDDKMNIIGILKSTVLQLDQESMAEIYSSISKILSPSKGKAGIRSLTVRHAIAELVGAIAVMDEQYREVADSLLKLTAVNSKRVDEMDFDVVIPELNKLSQPDAHKAWLSSCGGNDPSPPILNPLIAMCFHFLHNEDGVVLRVSHSALKMLIDLAARMAKRNDEVLWTKLVESSIMPFTRAGLQSRDASVRRYYILLVKGIAASFKDFSSANLCGDLHVLVNDENPDLDFFMNITHVQIHRRARGFQRLRSSLNDPSISERLSLQSVSNILLPITLHPLYECNTRADETFALEAIATVGSISRLLSWSKYNNMLWAMLTHFDRYPEQERYLIGAICATIDSFHFDLTTEKKDEDTDMAIDGDDQEQKTAVWRSLERRMIPKIEGLLMKEKVDRSGTRTKTIRPPITLALLKLFQKFPASFFEAKLPHLLSVICDALRNKDSDARDIARKNMAKIVVSMDLKYLADVIREISITLNEGYKLHVRAAVLHTILQELSALYKPPLEGETSPLYFDQSIGGQMELIQEDLFGEANERRESKETNVRYVKEAGGSKSIDSVELICRLLKFRPSDVATNGRNGSSIHCVVSPLLERLRQPDVDIYTIRKIRQLLTRVVVGLSHNPSVDAEQLFPFVYATVEPFVGQQTIAAAQKSEESDDEDMDDAMKPIKVSGSRELKEQKKEKKAGKVELWRPSTLKMVGSAKDAQEQKLEEKRTLRKVKDGASAPKLTGSGRHQLSNTASHNGLNDPASITAVIFGLNLLNSCLKKLNLDHESMPSRMDPFVPLLTACVCFSRESDVALVGLKCLMSLLRFDLPSISSCSENLGTQALEFLNSSGSSLNQNSDLTQACFRTLTYLIKSGSTTESGESGKRDILLEGEEALAKNGRMPLNSDQMKVLISTLQLSVTDSDQHNPALGLIKAILARRYISSELYDLMEVMLKLVVRSHTSALRQQSSTIFLRYLLDYPMGEQRFEKHLTQIVANTKYEYQDGRLSAIQLMTAVVEKLPDELLSKHTQSIFIPLVLQMVNDESDKCHDGLVKCLEILFTRSSREILQVIHVYMDRWAEQPGALRSASVEVLGILVDARSDFIQQKNLLPKLVESLHSYLEESNSDWQVSNSSILCVEKLSKKFDVEVSKAHKVWKCIVESLVNDHPSVRLSSCRVLHQFFAANLLDSFLTENPGMLFEIGRNICFQMNSSEKDIKDEASELCIKTLSMALPIMKEKPDLCFAKEEERNGRDPVYWLLQRLSQIAKPKGSKHRMAVFKCFAAFCTLHSAIVAPYLELILEPLHRSSIETRNQLENPHAVSRNQTPQSEALDVESNYATEVMQVVEETAVSSEVLLAAMSVVKKKARDKKDERKLAVKLEAANDPKAAAERKIRKQSREKNRVKRRVAERKQDRGSFKKRRSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCH6</accession>
    <name>A0AAD2FCH6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1922754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1922754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="552" mass="61047" checksum="1EB5F48ED2E2ACBB" modified="2024-05-29" version="1">MQPEFQGSGRSPEEDTRESFPKNADLVDDISNSALLLALLPALDDFNCLDAPVYKGRRSPWVRAFCQLYHPSGPWGENTFKNVPNQTSNSRHSFKSYKIPRIFALLENCSHLESSEPHKRVYKRLKDFKEKESYYKEFMEACKTLAVEEASKEASERAPIPKNVSELPRSAPVAGNSQNVIIVDDATPYEGKRIFLRNGVYVTQSSSSQANGAVPNQDTAFANTHNAEKNNTSSETTQAQNTAANRDGDRNVDRTAGTVDFDRDAQGHDNAKDNATNRNRERNVDLVVDTVNNKASTHNAEVGASSETIQLQNAAVNRDGDRNVDPTADAVGDEASTRNAETCPTSEAMQVQNTAVDRHEDKNANPTADAINDDTVEFESSFDNDPDEQENDWSSQETDEVEAVQVPLTQDAVDSAGNNDKMALDKKSSGKDAHANNDTEPSGKKRGSSSSESLSPKRRRFEMSTPTGNEPHEPSSPGTKGTMASLVKPVSPDTRPTTPIDREQILNRKRDKLSNMLQQRESRYGQEDTIIKKLHGQIMIIDEELLEMILAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFS4</accession>
    <name>A0AAD2FFS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1919282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFS4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052732">
        <property type="entry name" value="Cell-binding_unc_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43883:SF1">
        <property type="entry name" value="GLUCONOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43883">
        <property type="entry name" value="SLR0207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA ligase" evidence="1">
        <location>
            <begin position="167"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1919282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="395" mass="44412" checksum="128A3AA223444FA3" modified="2024-05-29" version="1">MPMSDQSVCTDPTSMIRQCRSAGKKGDLHQVVKVADAFCERIQGEKAMSKRRNNQMATVLGYKGFALAKQGLYSEALDCLEQSKLHRDNLSSPIHQNDQRRSERKMVDACLKTCYRRLGKAPPLPKLVKYPRTTHLFDSGGTATTVDDLVLPDLDCIIPTFCDGKSTVIVEEKVDGANLGLSLCPFSGQIMVQNRSHYITQGEHAQFSMIPVWIGEHREALISVLGEGDLIVYGEWLAARHSIPYQKLPGYFVAFDIYCKATGKFFSRERFHSALQDTQIPAVPIIAARTYHPSKSDGQTADQFRKELLALLETKSEFRLDGGTVEGIVLRIDGDNITQGNDSHSWLKHKFKIVRPDFVSGIGGHWSRRQIEKQQVDFDFANTYLDSCYPFSTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGF1</accession>
    <name>A0AAD2FGF1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS5200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="177"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1936455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="351" mass="40754" checksum="F7BE70B74F32EC18" modified="2024-05-29" version="1">MGKPFFTKKQKAAMRERKKRKRLQLTTLEQTNDETAPRAVQEPLNGAADSNKRQRTESLTEHAEPEKPQHEKKTELEIQTKIVNGIIHVLMPSDLSSKDARKYRKDARRKLRQEGKDDSNIEYITSDSVMEPKKKKKKSFPSIQELLKQQKIEVKQQKEEQKIQKKINEIPDYEKAQYVALDCEMVGIGTDGKKSALARVSLVDWDGNELLDTFVKVPIRVTDFRTHVSGVEPKHIKDQNAMEVEKCRDLVASLLKDKILVGHALSNDLRALMLTHHKHKIRDTAKYRPFQRYGNGKWRARKLRDLVKENLKDKEGFQEGEHDSVQDARATMELFHLVRSQWEKELTGKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHH2</accession>
    <name>A0AAD2FHH2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS6322</name>
        <name evidence="6" type="ORF">CYCCA115_LOCUS6323</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHH2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025508">
        <property type="entry name" value="DUF4395"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14340">
        <property type="entry name" value="DUF4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="67"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4395" evidence="4">
        <location>
            <begin position="227"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1938896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1938898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="43443" checksum="C499F36C9DB8C38F" modified="2024-05-29" version="1">MSAEKNNTNNIGDDWRLELFGQHVLLNSTVDQSKMTKDVENPEAPQEDAPYTVTESQPTQEFFEGYEYIALFFGANYCPFCKKFAPSVVAAKQFLEGKKCKTIFVSNDRDQDNFDQSCAKVRGLDVMEYDTTKTAAMRDLFGLKTIPALMILANKDFESKKPKIYSNAREILEVDPQCKNFPWGSIESRQAAPVTAWERIWISGKHGNWWQLGHRNVSEVHPGDMYMDEHAVRTRAGLLNIVTVVALMNVFFIEDPELVNIIFPLVAWEFTSSLIFGLTPFAPLGWIGTIMSTILQPTPLWKPANPKRFAWAIGLMLATTCFILVQYRKELGAAYKPSVTAVAFTCFLATWLEGNAGFCVGCFLYNNVLTKYFHYEECNECKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHH4</accession>
    <name>A0AAD2FHH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000202">
        <property type="protein sequence ID" value="CAJ1932073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="234" mass="27262" checksum="E2C5620CF8A15405" modified="2024-05-29" version="1">MRKSDEENREEDSGERNSTLQPCRNGTDPPILLLSDISVIVHIRDKASGTYAPLCSRSFQELFHQPSIHYELSEPLLLPTRLSGDFRDHFCKSFEECQKFPQRVSDELGVSMRLWRKDTNKSFCLCNKEEPSEVAGFKTTHKRATLFPIVGANEDEELLESYVNCFILPTFPPSYDRNIHNWSIDKVHGWKQYDIDDWKTIRYSISSFQFGITKEGGFKTVDEILEWLNVLDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHU6</accession>
    <name>A0AAD2FHU6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000845">
        <property type="protein sequence ID" value="CAJ1939762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="101" mass="11295" checksum="BB911549FFCFE2BC" modified="2024-05-29" version="1">MRQTGASPFSFHRFVDRGTNDIGSLVTDLGDLQEPPEEEIVFEPETPQVAKVTQSGQTYAQVAMSWLNLSQVPEKPREWPSSRSGSSANKNKNQDATRHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI08</accession>
    <name>A0AAD2FI08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000001">
        <property type="entry name" value="DNA cross-link repair 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF35">
        <property type="entry name" value="DNA REPAIR METALLO-BETA-LACTAMASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="619"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1940226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="749" mass="83764" checksum="74E0579576604386" modified="2024-05-29" version="1">MVRTIRTCDACQSRFISFANKKLCTECRTAENSDVEVAFKCSTSAPKRLAFSNESSSSLSSPESVVARQDAKITEEELRPSNSPQECEAIDFCSPEVKVNENRSADDENESKLQILDDDIDNGNNDYGGAGVSEGEDEVHCTQLPNDSDDEGDGEEEVQVVEVDNSSNHRGQDQQEESNVANGNIAGSINDLGAESSHQETNTSDFLQSSKNNDICFICGADLTKLKRRVDHIKRCSKKHGITGRDVKINNDHEEFVDIEHLQQKETAKPTNNPYSKFRESDWHGNATKMLQEEANNDAAWSSVAVSAQPVAAVAAIAGDDKRATKQTTLASFVKMPIRNLNNVLLNGARRISKLGEITNQRAATRKDNVTPSNSRKRRRSGNSNFSSSTRSCPLYKRITGTDFVCDGFQYAKSAQTNNHFLTHFHADHYGGITSGWSHGIIYCSVPTAALVAQQLGVDKKFIHPLPMLTPTVIQSSRNNKPVTVTLLDANHCPGAVMFLFEVGKKKILHVGDFRWNREFMMQQAPLRALHRETLDELFLDTTYCDPKYSLPTQEEAIQATIKVFEAETKNKGKTLFLFGSYTIGKERIYMRVASRFGMKVYVDTRRYKILSALQWSREQLELLTTRKEEASIWVVPLGDINFKKMLDYIPLANSKPFSFPYKRVVGYRPTGWSMGGKPSSGIISTRQKDNMTVHSVPYSEHSSFPELLDCLECLKPQRIVPTVSVSKSDEQVQLLLGSLRHKQTKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIG8</accession>
    <name>A0AAD2FIG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1995 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053021">
        <property type="entry name" value="Chloroplast_ADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018962">
        <property type="entry name" value="DUF1995"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF1995)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF1995)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09353">
        <property type="entry name" value="DUF1995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042005994" description="DUF1995 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1995" evidence="2">
        <location>
            <begin position="49"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="367" mass="40294" checksum="06A9ADF25F3F67A5" modified="2024-05-29" version="1">MMNPLGCALLLALTGSVVSFTSTRPSHAQIISPLFSTPTETVSTPTELPDSMEDAAEIAAKACAQFAEASGPLGRCRITFDTSAGDETYTILKTSSEFMQNVVSYVCYQMIPGLQEIRQGEMMKVAQARAELQAILDQEEAGDADVDQEKKASCIQILETGGRDPDYKWEGPNVRVYFPDEGSAALARRDWMGNSAAESKVPPCVLFSSCGGVQMGDVSKDEIIFFFCPKASESGDVEKLLMKTETTSDNLKLTVFVNPNLVDMGVTGFGMAGRQLRERLLDGLVDTYYLRTLQWGALTRTWPNAYSVWQEDEESEGGYKLIKSLPYLPSNPEVEDIYDIANGLMDEREGGGFLDQFGDFVNGMMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIJ5</accession>
    <name>A0AAD2FIJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="388" mass="44787" checksum="B9B4BA87E3815092" modified="2024-05-29" version="1">MSENVSLNNNKGIRVVTVLLGLVLLGLLLNPLLGVSWICRNRGTTGAHPSEFSRRHDKNEALSESYSSTATVQTPPLLSTNDTPGDQVPVLSEPKIPHRFVFNSYKDFWNVDVNDLEKEEHRAIHRLLRRTVVMFKKVWREKGYTNTSMEEAIEIDFMNESLDGVEVVFLTDKDCEELIKSMEPKMTEAFLNERNGKHRSDICRVFSLYEKGGYYLDTDLLVHEAPYLMPHVTFASVIEPKFQDKFLQAFIAVAPKHPIIIEAINVMMEHYVTKKGEVTGESMGYNSNKNMGTWTLREAHKRVMRRLPNMANEMVLLQELPIDDYPNWFPEVPRPHKTKMKMMRFVTVNLAAHKLHFWSKGYRNRFLKEIYHLDDLAGFVPRNTTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIK2</accession>
    <name>A0AAD2FIK2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001024">
        <property type="protein sequence ID" value="CAJ1941506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIK2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042167">
        <property type="term" value="P:heme catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1941506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="348" mass="39061" checksum="1231F54A7BAE2862" modified="2024-05-29" version="1">MPQISTPLQIEKDEDGSFSNSSCRYAKAIHESEVSSSLPGLLELRQCPVFSEECPFKSASNPQDFRHQLKRIPLGHMAKDGPLYNSLKFFHESKENPSGNKCPVRGQVSVPEEWSFHQTVEELSLISIMAEMALAIEQEDFRSVDSEGNAETSAATDSSTLSPIPSEVRDTDKYPSRPSLSDALKTGTANSHQAAEGVQFVKQFVRGKIDRELYGLMIAQLYHLYGSLEIALDRHAPALFNSCHFSNELHRRAALQEDVEFWHTNTPTISPATRDYIDRIEHLSENKPLLLLAHAYTRHLGDLSGGKVLARVAKRALLLVDDDGLAFYHFPQVKSFKLFKDKYRAICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIP7</accession>
    <name>A0AAD2FIP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIP7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="21572" checksum="483DFAB410BCA9E1" modified="2024-05-29" version="1">MEPSTASNVNGPRPASELVVTVTPVRELVFDIPDATNACHGIPFFSKGSPHRAYQIEISEEGHTHYETADENDLGINYSKSDHDDHSPLCIKAQIRFSTFRRHFMSYPMQHLTRNSRPLIPPKGAVWEDYTHSVENVLERARRMQLFLWDVLNSNGPEILRSHLLQETLSLSPGDRQGLLRIAERRESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ90</accession>
    <name>A0AAD2FJ90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31154" checksum="4977608A50AEE7E6" modified="2024-05-29" version="1">MTLDFSVKGKLKIRMDNYVKNMLEDFPIKFNKDSKQETPAGNDLLEDGKGKLLRADYRQIFHTTVARGLYVSKRARLDFHPTITIIASRVREPTQSDWKKCVRMMRYLFCTLLYHLTLSAESLRVMKWMIDASFVVHPDFKSHTGGTLSFGGDAAQVMSKKQKLNSRSSTEAELIAVEDVVMMILWTKLFMEWQGYPIEKNILYQDNKSTILLEENGRKSTGKRSRAINILYFFITDQLEKGNVKIEYFPTDNIIADFMTKVRSFASSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK36</accession>
    <name>A0AAD2FK36_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001525">
        <property type="protein sequence ID" value="CAJ1945808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="131" mass="15163" checksum="B5596AE60B5FF477" modified="2024-05-29" version="1">MDDIKAEIAEVKKKLEACENDLKECEDKVKKCKDSIQNDDTDACFQNAHQGSKDVKKEKRAEFLMEEEIHLMKIGNHLRTKENQLRAEKSILDERLNNARQGSLVNNRDQSNANVIVPSNLRYTRYQGLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLE2</accession>
    <name>A0AAD2FLE2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLE2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000306">
        <property type="entry name" value="Putative ubiquitin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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</entry>
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                <person name="Bilcke G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Bilcke G."/>
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        <location>
            <position position="1"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAJ1946497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="7129" mass="811366" checksum="B86C1EF7D0255014" modified="2024-05-29" version="1" fragment="single">[encoded data, 7129 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPH2</accession>
    <name>A0AAD2FPH2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11605</name>
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    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPH2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPT1</accession>
    <name>A0AAD2FPT1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
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            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAJ1948901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
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            <begin position="324"/>
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            <end position="127"/>
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            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAJ1948901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="360" mass="40131" checksum="DA1BD9B6F2952C29" modified="2024-05-29" version="1">MTLDQPSNNMSGSRKRRYQDRREFRASRSSFSSVNSWLLTPLHCFAILLLHTGGAMANVQVVALSYQHSPRTSASPAFIIPSHPLVPPVRNTATSSSTPKKQKTVTTSQRAAKSTTASIQNNKSGTNKNEHKSSVTFVGDSTTTLELDAPMELVQEFLQSDSSNVYLLGTDDIQCHDDHDESQQLLYECKQPIIEFMGLQLQPTFRHKLYRQPNQVTASIEEGSKAEIVTHSRHPAKRVISSLVHDATFVGESVVTVHPQEAQDHATQKCKLSINLSLSLQIPMPRFIPIPPGFNALGGAIVRRAGRLRTQQLLERLKAAYYQHQQEQQQEQQGRNPAPTITNPSVPSFEDNFRRILAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPZ5</accession>
    <name>A0AAD2FPZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
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        </lineage>
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            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
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        <location>
            <begin position="101"/>
            <end position="146"/>
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    </feature>
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            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="146" mass="15848" checksum="681A84B1FD41A90D" modified="2024-05-29" version="1">MEAYFATLTKASGASGFLIVRDDAVSPVLKKTVNKQFSSSSESYCSSISSTSSNPCLGPPSLPRRKRSSDDLSSKVTTTRSGEKGAKTRVLKSFFDEVMGPAAESSKRDRSHDAMDYMHDAIHITSPSSSNSRKTTKQSKRWDANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQT7</accession>
    <name>A0AAD2FQT7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Meiotic nuclear division protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS12209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQT7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="7">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="8">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1949661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24355" checksum="D350DF735D62217D" modified="2024-05-29" version="1">MGGTKRMTKDEKRNVILGLYHKTQQVYTEKEMITLASKAGINAQTIPDIHQSLVDDALVEKQKIGGTNYCWSFKSKKDRMAQKQHKATLEQIEALQPKVEEAKARLADAKRGREEVEVGEDGGTEEDTRAAKLAKLSTLAQTKAALEQQLQALKENDPAALANLEKEYQLVRDAANRWTDNIFECKSYLVKKKGMDKKEVNKILGITANFDYPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQV4</accession>
    <name>A0AAD2FQV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS12252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQV4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="240"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1949747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="373" mass="42877" checksum="213DFAF803C99178" modified="2024-05-29" version="1">MSLRRSSGFVRYAISCQYHGSSFLGFVYQGNQEDQINQHGTDLRGYRSVEGRIREALEDFLGSSADYENIQVSSRTDRGVHALKNTFHVDILHSNSSAIKTQEEMERRLRRGLNYHLGRQVSSWDRDQHFQKRKRQRSKVPANYTYFSDSYWARYSANDELKILSVKQAPDFMDNPYSKQDTSQPPTVDWNARFSATERTYVYRLLCYPSQDGNWSVPFEWDRSWRIRSRSMNYEAMQEAALSMEGTHDFSSFRASKCIRKSPVVTMKSIKVHSQPYGPWNILGGDQGLWTGQDGLDSDYPIPQLVSIRIVGNSFLYRQVRNMVGCLAQVGTGKIDPGDIKGLLEQKDRRKAPTMAPAHGLFLADVKHGDFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUR3</accession>
    <name>A0AAD2FUR3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUR3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="46"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="233" mass="25675" checksum="A850D232420C8B97" modified="2024-05-29" version="1">MSTNQAKPSAERQPTKDSKLDDSQMKSSAAHRASNNSKAMVAKPGDIICGRGFHIANHRGNLDLHLIINKHRDEYLQSKRPNKTRIIKHILQEIKKTGARFIKSVSDESNVDTWEEVDYETAYKKVSHALRLKKKNETNRSNGSIMGETDSSQHRGDSNGGSGQLIPSRVTLPVVQHGPSPGQLQVSSGRFSHAAGVPPPQLGGPALSQIYRQVYLNTLYSLQHQPGKSPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUR4</accession>
    <name>A0AAD2FUR4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS14562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUR4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="91"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1953964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="693" mass="76616" checksum="6EDA5E4981398B11" modified="2024-05-29" version="1">MASSLSAASVSASFSSSLAMGVDVIPVQRTKHRILKSFHAQQLHHRNRRLEALDRRRRRLTEAEYSHPSQWRRSAKEVAAVPLSNCHMILWSGMISIGTPPQQFLVDFDTGSSDIWVPSMDCDNTCSAFPNWNKFDETSSTSFSTPVNLTGKFSAVYEDGESVHGSYADDIIHLSDDLNVRQVFAQVTSVYEFESCEGEDGVLGLAFTYDDEREYTPLLKNIKDKLMHPMYSLYLNGEDDYPNDSKLQGASDLYGNLESGLYSTPPNATSEFVLGGVNQKHYTGCLNWHTLGEFNDPTYGQKFEGFWDFSLDLVKVGGTKMTTANVALVDTGSSYIVGPPDDVAQFAVLNNAKCFVVDTTTNAFAPPQEVDCMRPEGFDASIIACNEPFFNLEFIADGVTYVMEKEDLILQIPTSFGDACVLRVVGSDGIPGWVLGDAFVNKYYTAFDFGNKRVGFARGVAESNDICEGDIGIDIGNKYKNPSTGDDDDTDTDPDTDTPTRAPSIPVIIDDLDGSELDEDLAQFEEELDEDLVQFEEDEAEEDDDDDDEYVFPTLSPTIFGAPTATPHHHHFDLGTDSPTDLPGGADENNVQSLAGNPPKDTGKKGAPFFSVVAFFIVAIGASALYQQFKKRQKKNLPKSEQNLRQFHDEFEDQLDEQNGGGGFRDVELDSDSDEENDDDVFILDADTLHRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVR4</accession>
    <name>A0AAD2FVR4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS14919</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVR4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="164"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="807"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="749"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="845"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="755"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1954327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1038" mass="112644" checksum="1317DA3FE963321E" modified="2024-05-29" version="1">MTKITEIEGKSAVAAWSPIQSCSDVIAIGTKDSGGIGFEDNGSALDLYDLDLSNGDEPRLLGSVKTEARFSSVCWSPETLGGKYPMGLLTGGMENGVIHVWNPKAIMKNQQSLIRTIKGHATGPVKALQFNPLNLSQLATGGSDGKVLIVNLDKEDEVFMPCESTQQNAQITAVAWNTQVSHIVASAAADGTVSVWDLKSKKSWCNLRCESAGKAVADLAWNPSEGLHLLTASADDNNPVIKLWDLRSSTSMPLTTLTGHSQGILSMAWCPHDEHLLLSCGKDNRTILWDLFTLTPIGEVPIDEVDHQTDTNSNSQEMFAAGGLASNHQRRYDVQWSPIKRGVTLTCSLDRKVQAHSILGLSSSSARPPKWMRPSSSVSFGFGGSLVSCGSTDRYIRMSTVVEEESFAKLSAEFESVLQTTNVAEYCYERATKTKVTSEAELWAFMQIIFDPNSRQQLLGMLGFDPEMIASKANAYAEDNLTNGIEKLAVDDKPAGPMTKTTEQMVKQAIMVGNFDAAVECCFRMGHAADALLLASYGGGDLWTKTQQRYFEAQVEKRNFLPLVSAVFGDGLADLVQKSDPEDWKETLAIILTYAKTEEYHVLCDALGDLLEQYGDDRHASLCFMCSMNLGKVGKYWRQQLDEVNKAKGSLDLAALHEYAVKVTIFLVAVGPTSKLCLEDAELFSKYSSKLAEQGLLVSAAKYSTPDSYEGKVLRDRLYRSKASPSCLAAMGGVAPEFPFDMTNVKMSRAEPAKTTRNTRQMRTQASTASNYSQYSQVSAMSNSYAGQSQQRSATPTPSVTQPASAGTLPDGWIELQDPSSGMMYYANQTTGETTWERPQPVAAQALPPAPQPEPQKTTPATPSRPNKLASKYGDGFVTSASHPELASQYGNVGTSNPYGGARAGIASVSTVEKPPVSGTFDPNNIPELSAELQPIKDCLIGVIDALKADPSMGGSDKRLLSESERGVAVLLKRLALGDIQPEICAKVLQMIGFITTYDFGSAQSVLTDLVSSEWRGHKDWLKGVKALLQLARKIWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVT2</accession>
    <name>A0AAD2FVT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS14949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVT2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF2">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="6">
        <location>
            <begin position="188"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1954357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43937" checksum="4E35CB8C6481A3E6" modified="2024-05-29" version="1">MDVVRSLGLEDVPEQQTRIGLFLSSGGELVEDVKVGFDVCVACGNSNPKIYCQACKRVKYCSDACKKKDTTPPDDDEEQALGHSSIVCTLLRTCNDDELVEGKEDKGMPEAKRTPAFDRVASEMESYPATLANIIFEGPCFQEKLQKNSGGEVEIHVIGTSPDSELWEGHPDSSQEKKVFKCYAEALSEMADRFKFESIQLKFIGPECPKIDMVDTILIPSMKNRKIKCKLNVMTKRVNYSKSLLNGKHFNCPDIVVFFNPGFTCPDYTWEEAVSAIPGGTPYLVTTNTELEGIADAQYLMENSFIAHLPEGLAHILEPDAPRTEIEDNETFFSINPFSGERVRQSGTMANDLYVKSRWILGGKLLGSESKESKTSKKRQKVTGSGNTKKNNPALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW54</accession>
    <name>A0AAD2FW54_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW54"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042203604" evidence="2">
        <location>
            <begin position="25"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="318" mass="35369" checksum="413A177FC285D2DE" modified="2024-05-29" version="1">MTSNPSRRLTVSLLLFCIATLAIAGQGHGSVVGAQSVPSSPGGYYQANHDDETSSSSSSCQDPLLVRGGDSAFESKISDFLSQKDVSMEKFHVHGWRWHTMSLVREAGRLKKLAQRSSSKDGCRPIKQAVDYVVGFNMKGLHKIEADLFFPWMRKKLTSVDQKDLAQAFGSVMDQLERDRKRVAKLGESIQQQVSLLCDESKALTLRADAVISIARDAAELETVARTMMETENTLLVPSVAEVVPEGEQKSFNNKVLRNLGILDSRLHLVGMHEAVWESNITKEKEMFKKAIPSIPQGLIPRWKRNLYIPKTNVLDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW81</accession>
    <name>A0AAD2FW81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS15221</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052:SF63">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="12">
        <location>
            <begin position="239"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1954627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="658" mass="72781" checksum="5305D1B003D17757" modified="2024-05-29" version="1">MDPAGKAFIYDNVEQDDAPDNPPDADGDVFEDEIVFNIEDEEADNGNEGLMFEEGAEAGSPTSPPVSGSNRKVICSCLVLAIAVLTTLAIILTVDVEEVAERNSAMEGDYSKKDQLIDVLMMRGIAVEKVLRSFSDAQGQAVGFLAEEDWDGEMSWLYGDFEGNLPLIIERYVLAVIYFECEGIDWFHAYEFLTAQDHCDWNTVFEIDGEATIEGVTSCNGDGLVERLYFPINNLRCQDGLPDEIRYLSNLEALVARGNTIEGEFPFFVRELTNLSVLSFGYNEMEGTLPVWLGEMTLLSVLHLSDNTFVGEMPPSLNQLTNLKYLGMDDNFFTGNLNDYLPSLVNLEWLYMEDNQFTGPLDWLNSLDSLSYLDVSKNKLTGDLPSNLFDHPNLSIMDLHGNEFTGKLPTVTKQNGELQLFSVHSNDLTGTIPIELQSIVNITMLDLSFNSFTGTIPALSETTRLRFLMTSGNSFNQQEMPFIAGLTSLVELSMKGNNIVGNIPQWVGDLTNMKWLDLDANELIGTIPSEIAKLSGLYALLLNRNDLDGTLPTEISQLQGLEVFLIDGNDITGETSAICNKADKIDFFISDCGSAEGQQPQLDCPCCTVCCITGDTECSDLAWTSMHDPVVENEFSRGYSFNYSDASAQFTKLNDVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWA1</accession>
    <name>A0AAD2FWA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWA1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007346">
        <property type="entry name" value="Endonuclease-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33607">
        <property type="entry name" value="ENDONUCLEASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33607:SF2">
        <property type="entry name" value="ENDONUCLEASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04231">
        <property type="entry name" value="Endonuclease_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042027712" description="Subtilisin" evidence="3">
        <location>
            <begin position="19"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="56895" checksum="934971E29AC5BA96" modified="2024-05-29" version="1">MKYTAATTFAAVVSVASAQSSYGGCAQGAYYGGLDLGADRASLRTYLGNLLHDTHRGIWPGTNVNEPGVADTWAALMDLDQGSFPGQVRLLYAQQDVDAVPFAGSRGWTKEQIFPINRGVGVDGIDLNDLHNLRPTTYLSNVVRGDKYFGECGILTPAETCVNPAEGGTEGTCTCNRIYTPPPEVQGDIARALMYMDLRYDGRDDNTLNLRLTDCPFQHERDMAYLSQMITWHKADPPDDAERARNDKACGTWQGNRNPLVDFPELVDLLWDPPLPLPAIGERQIYEACELIPTDPPTLEPNQCEQLLPGDIYFWLINSQSPATLGLFAFVEMDPGFKLFMTTNPWDGEKFNTNQGGTVSLEVPGDGVDGGTPFGFGESALLFYNSWLSESGAFEPSSDGQPIFLYCLDNFDNPRPLLAFLYGNSKFSAPGQASYPTGESARPESLGELGVIKVAPGFSNAVFNEDVDGYANDELKAIIRDPDSWKVSNEDRFGPASSATINTTTSIAMVVIGVITLATSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXK1</accession>
    <name>A0AAD2FXK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipoxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1955964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="65026" checksum="18039FC48224E85D" modified="2024-05-29" version="1">MSFLLKWGAGAVCHQSVIDALVDMKTRESLDEETELTDESKKILSQKVGEDSFVLILSLKGPAAIIESNENAPTDADVMTEEVDLGWKKIGDNFDDPWIKIPIIPKVTKKISKEFTIEILAEDDMMTKFSLKERIKAKVYTSRVIFPLTDLDVSIGDETAKVLLDDLDYSPGKALPVSYTSDFDMLSDESFSRIFFAGMGCVLLAKQEKVFDSKHGPFMVDMPLQDLKLRDKDKYRPYGARIHFSADRLVTAIYDYDKAKEFLPGEVGWAAAKMLARTTAFLLMTAREHLIWTHFLVSNVATREKTIHLPPNHPIRRLLTVFTYGATEVNINAYSTLIPDTCILHRSTALKYKSLKDVFASSFTSSNIYEPFSERKYNPALQKLIDEGKFPYASEGEEYYEIVRKFVKDWLKKSGDAATDAQATAFYNGVKASTKGQAYELPEMSQENAMVNLLSSIIFTVTAYHEIIGHVVDYAILPSKAGFRLNKKDPLHIDLQSFLYTEIISASTSTKMPQLFGFFRNYFSSAGAPSWEREVWNSFQSDLRSQSTKVQEDDAAREVEFKYFDPANFECSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY41</accession>
    <name>A0AAD2FY41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="86" mass="9673" checksum="2BE87A1DEAAFCFF8" modified="2024-05-29" version="1">MVDSKMLELNSGVETNETIGVEQLDWASEMEEDGTFAGMLQMQHSEDRVRVVDLRMEETQLGAARLVGLRQCDLELTTIFLALVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZF0</accession>
    <name>A0AAD2FZF0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZF0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="332" mass="37352" checksum="E78A3F62C711691F" modified="2024-05-29" version="1">MSTHRIKRGRHQPVETPKATNTNNNKVKRLTLTDWYELCEKFVAAKEEAPSLSRNAFLRSKASGPNFEDNQTMRNGFHRSLKKYNSGELKPCNRLRMRSRKYHAIEEKLLQYMQQQQQQQSKRHHYHPAQDIINNTMMLPYPEIKKRCLTWAKELGLDGFKCSNKWISDVLSRRAEIATVTNRKEGSGDRTTITKVDNDATATASASAGTNEQQRQQDHTASPVIGNKASEKDAATATVEKQVPPAKASVEASKISRTQTPVVVVAAAAATTTTSGKDFLEQGDNRSSDDEDISLERVLTGLKDVQTYCKKRKLDDASSLLQIVKKFINEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZJ0</accession>
    <name>A0AAD2FZJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001968">
        <property type="protein sequence ID" value="CAJ1958104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="234" mass="26457" checksum="D3F8C82E8205DA7F" modified="2024-05-29" version="1" fragment="single">MSVAPKDIMNFVCLLSSLTHDFKKRQKGEKKITFEHVVPSCVIEMGKESRVHSGERILKRAIRNTLDPGTQRVDSAKFIFGYFQGDPCLVVLDHKVKASMRNAEYSVECAFTAEHLVASACKCKAGCRNRSLANLGTQRVFCTLGLFPLLQLSHLLFTFLAEHLLYELRIRLGRDEEAFSRLDIEDRTRKVQSVGIALLETIHWKLLDRSSSTRPIGQTDKCPFGPFIRGIPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZP6</accession>
    <name>A0AAD2FZP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001928">
        <property type="protein sequence ID" value="CAJ1956970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="181" mass="19649" checksum="B72E8D9C68460844" modified="2024-05-29" version="1">MSEADFLAHAQDGIMGSNETSTLTPAQEPEDGPPDKLLATQHTTKPGELQRVMSDKLAVAPATKHLPPTPQQEVKQDEFMLNGVKYRSVNNHTIIYSIQKVNTRKHLALIDRGANGGIGDDACIIHKTNSGLIHTQRGPAIAIMHQQAYIGKGQSILSSGQMEHFKIVVDEKSTKAGGQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0W0</accession>
    <name>A0AAD2G0W0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0W0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="171" mass="18569" checksum="F099F346DC5244C3" modified="2024-05-29" version="1">MSTSGGETSKTIYGVPESGWTSPKWNWGYASGTGHDCAAICRQVYSAKQSREVLVNDLIAASGQPEDFEEVKLVLGLAFQNGRWDGSDGGQGGYGVVLSHLAEAQRYEVGSEEQCSKNFVQDMQARFQLLGPSPEDQALMDEQLDEPNVDAARRRCSGLVLKTMGFLKNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1A8</accession>
    <name>A0AAD2G1A8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002004">
        <property type="protein sequence ID" value="CAJ1959582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1A8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="106"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="493" mass="54235" checksum="56ED06EC30977881" modified="2024-05-29" version="1">MSNGASSKGTDSQTAPTQKSSDASKGIYPAGEVSSLSYTDLCAGPSSNGSESRTAETQKSSNASKGSYQDGDINSSSSRHDASYSTANSQSSKQNELGVKMAQLGLFGRNKEIKTIRKCLDDLVATGQKKLLYISGLSGTGKTALAVTVADAVAKKKGIFSMGKFDQKLRGEPYAGIAAAGRHICGEILHLKHSGEQMGSLSFEDIQETIIEKVGPELATLILILPEIEDIVGDSSEYLAQDDPQGGDHGANKERLNGAIRSFFRTIASFFNPLVMVLDDIQWADLPSINLMEVLMTDNSSNNFMLIALYRSNEVDGSHVVNKLIRNLDEKQDEYDYDTTKIAVGDLKVEQVEEILAGIFQIPCYRTSDLAEIVHQRTGGNAFFVLNFIYMLSNEKLIAYSRAEKSWVWDENQIELETVASDNVVSLLKEKMKNLPPKMQEVLQLAACLGASFREDFLSRVVKDYFKERPLKPNELSKWSNVDGRKRSNQWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2U7</accession>
    <name>A0AAD2G2U7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2U7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="169" mass="18957" checksum="6DA4AB29322B09CA" modified="2024-05-29" version="1">MDCRWTLTDDSSPLPFPQKTLPYEIHAPQSCYALVSMLTLGEDYGDDSILDESPTKLLFDRHTKRVNATLGNEERLLREKRNSSMPMMKPQRKKSMEDLAHLESALNAVFDLIIEAPEGAGCQWDCEESSIPSAAGAKWSTHVMTEVLKKPVRRSSLGYAPHSPHRSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5E2</accession>
    <name>A0AAD2G5E2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002142">
        <property type="protein sequence ID" value="CAJ1963379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5E2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="405" mass="45105" checksum="B2B66C7A2612F7F0" modified="2024-05-29" version="1">MVITNAQNTAFFTHDDQMAIPPGIFAPHLNQQGITTIDSLKEFNDGMLDDIHKHITRHGPPNVVFSALSLSRLKAAASAVRFYLATGRALTAACMRWTNTLIMYQEEREALKIAQEREDPKVPCVSKALPIMKWLAAFRSIIHESYGDNARVFAKLEEALRGTTYALSLTPFEQTRDGRGAFFAIVAQYLGKEKWSKEIEKNTDFITVQKWKGNGTFPLERFIGGHCNAHQALLTASQHVEYQIPNEHTRIGYLLRALHTTDPGLHATIANIEGNEDPNGPRYSFEECARLLQLADPVAKKNKRSHAQISDTTVTIDESANQTIEIASLRSGIGKTGVHLRFYKKKELDKLPAEQRAELKAWRLTPEGKAATARDRAAKAKAHCGNSSSKKEGKISAAAFEKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5H7</accession>
    <name>A0AAD2G5H7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS20270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5H7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130">
        <property type="entry name" value="CYTOCHROME B561 AND DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130:SF171">
        <property type="entry name" value="OS01G0895300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042292245" description="Cytochrome b561 domain-containing protein" evidence="10">
        <location>
            <begin position="30"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="11">
        <location>
            <begin position="43"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="11">
        <location>
            <begin position="234"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="350"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1963675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="61357" checksum="4FDF10F827C3CFE9" modified="2024-05-29" version="1">MHPFTNLLKRGWLLLIVAAFCLNVKLASAAFTSVSLAGSLTGATLETQINLADPNASGQDTITVRYTVPQTSWLAVGVNPAGTMPNGEVVIGKPDDNNSVRKYKITARGAGAISEQPNQTLINPSLQQTGGNTVLTFTKLLVEDGEFTITAAASNTFIAAFGSSNTFSYHQGFGSQAVTLDDGSNPGPDASPTPPPTTAAPVPTNPPTTAAPFEAPTNPPGADVLELTGDLQGSSLSYQFTFGDPNTGDKDSITVTYTAPVTAWVGVGASESGFMLGSTAIIGLPSTGEVKKYSLNAKTTPGVSVMPDDQQTLVNVGITQANGFTTLTYTKILVEDGEVPINRVGDNIFVAAHGSSNTLGYHSVRGSFSLSGKVIERDNSLWVVHGWLAAIAWGVMCPLAILAGLFRKYIPGEGIWFQIHRVLQTLVIVLTIASVSVAIAALNKETPASLSADHFNSDFSDGHRLIGLLVLIFGIVQAANGIMRPHLPPKPEPNDDEQGNKSTPPPAGEKSGTRKFWEVLHRLLGVGLLALTWYQIKLGIFWYHEIFNNGESESTLNAFYGVIGVLGVLIVIGVAMRVLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5U2</accession>
    <name>A0AAD2G5U2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002062">
        <property type="protein sequence ID" value="CAJ1960551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5U2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="573" mass="64125" checksum="F2591154C771EDA1" modified="2024-05-29" version="1">MGKSTSLNVVSTTANKAGGSTPKSVSVAKKSEKKRLENASAVDLRQPKDRDPSVNNDSEIQELIASLPPLIDFGLSTHELIAIGYDYNSTKISFGNSIFNQWMENHNDRWTQALPRFDSPFKDLYANYSVEVRVNMLFAQYANDWRRVLKFLISLFDDDALGNVETNTEYTWEVRAIALQVAQQIPFSFFDVGLVNDSKVPQEDLYFLRDNRTNPSLRNETPLVQFWLMCASIFDHPWTMLFDKFLEGSPISCIQEIKLKVIKGFPNDKTNKVDIHKGVKKIFDPDYKDSEEEDDPMGDEDTGLVNKFGQPNGWDSDKTVDDNSNHRRNDMEIDGKLDSGEDRTHDNDDDKGEVEEDDEDTDESTKDSVILVESTYKLTDTANNKDTNNMGLNTDEAVSELTGVTGEDKDPELASPSRKKGRSHRVSVVAPSTEMDVDGSSLSEPSAKRTHSASASQSTTPTAPKTDTTSTTQSSKAKRRLQRSLTLEERLDGLRQVNLDGMDGQAILVELGMAYSYQGQQGGNTTHASIILNHILDTLADVLKNAEETIRFLPLSDSAYKKSKQWIRTEADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G619</accession>
    <name>A0AAD2G619_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002118">
        <property type="protein sequence ID" value="CAJ1962773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G619"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="609" mass="68746" checksum="308F166305D33A8D" modified="2024-05-29" version="1">MKPNTTEGRLCLPKARHAENNGLWKCRQYYYRTLESPLTCGLGSSPAPDKFYLPDMVRIWKPKEQFHSIQFDYKCPHCKSCSIEHNAQTWRPAFEHNEIRWVYCHCLLCKDCNAMFSSTDPSFLGMLPTSIAESFEFVFPPQGPGVHRVMLRRLSLQIDNHVLFGAWAREVNDLLWEKYFQKCNQYYEVLNDWLAKWPSPSCYDSTVPLHARDGKGQYDGRPIVPYSAFGAAGHHNGIMMTEGLAKTLFRLVEGGKRFQYNQNSFAAWHDGGLRADDTFKLPKKVYVTTSGGNRTSMSHAANRLILQGLKIARDHVGAPPLRLLQTDNPIGEQAPYYEVFPELEQGIVARASLPMIEIPPDDIVSFDVGSVLNAYILTLIDIFIQHDDQEIFYGLDTEFGRDSKLTVLSLAFPQSLRGSELGTTVPIAIVIHLHKIGKEQFPADLKRLLELPSMIPTGRLIGGDCKKLEEQYGIKFNRMIELGNLCRLDNGELSSFSLCNLIKVYLQCMYPMNKSAAQLSSYAKPTLTPTDKQYCTLDAVVSLWVFHRMVESLANGIGNQHPTLQVGKRCTVTHNAKDIAFGHLIFVGARGEQMVGWCDIGQKGLPCCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G634</accession>
    <name>A0AAD2G634_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS18930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002077">
        <property type="protein sequence ID" value="CAJ1960871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G634"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042120560" description="Transcriptional regulatory protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="4">
        <location>
            <begin position="45"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="3">
        <location>
            <begin position="121"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1960871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30326" checksum="342E953662F2F4EA" modified="2024-05-29" version="1">MRSTITFILSTLLIHNVTPFSPVQQPGAVAKTNGRLQPLFMGRAAAVRAATKSKTDAKKAKTNAVFGKRIIMAVKQGGSPDPNANRLLGDIIKQAKAGNVPVDNINRAIKRATEGNAGDFSESTFEAYGFGGASFVINVLSDNPNRANADVRSTVNKRQAKIAEQGSVLFMYDRKGKVEVPAVLDEEQLLDAAIEADIDDFLLLEGDEEDTSVVYVEPTDSANMLGVVNTLGYEEAKMSLAWVTKAPVECTDDDFDKNMEIIEALEELDDVDSVEHNMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6Y1</accession>
    <name>A0AAD2G6Y1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS20997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="52"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="798"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2284"/>
            <end position="2400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3069"/>
            <end position="3115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2347"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2373"/>
            <end position="2392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1965199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3115" mass="353489" checksum="20B38C61DE8FECE2" modified="2024-05-29" version="1">MEAAERQPEKDEQEQPMFVDTSMLESDIQTLESEIMTPSPMMMKTALHEGLDTNYQTPGGKINVEEDNATVSSVRTPADNLLDKFQSLNDSWVDVKTRSASTKKRAIDTPSMEDLMDSPMPNFASALNDYCTAERDDENDEHDDVSSMGDSTTSTISSQESVFDRLHRHGTSQQRRRRRNQKSSDPFTSPREHTSTNDFFTPSSATSSVSSTTSRSRKSASKQQTKKVRNRVVPTSAAKSSATRSRSNSESKVSPASSQDSVFDRLYRNQKRTEILWHAPPTPQLVSRSIDRKRSGRRKNDTRRPSKIPAPSTPQTASKPQLKKKRISSTPATVVPKSQGMTIEDSEGNNSIEPLSETASAAAASSLAEDSTTDSTAVRSPAAETLDAVSTASEKENKLRPRAVAAPREQPTALKNANWSTTSIDEDLAELAAIQLDLDQQQQHLAPTPRKTNVPVGKSIGKTSSVEPKQLYTYNPSTAIANSLLGDVEDILKPQVTRSTAPSVASTATHTHVEDDDATSRASSGFFTLDHAQSSFTLQPLVSFPKDSIGSKQATVQESVPNEKAAIAIQSWWKSCLAQVSLANLVIEHRNTTFPSAHDTSPRVLLRIISSTHPHDLMTEQHHNVLVAESSQLSLEIRLAKPSFSKLRRQLSNSMLLRSALASARLEFEGIIFVEASQTIQRWWRRRKYIERKSATTPSSTHKVMGGARKKELSFYLEDVTGGLLDEELLETLSKDSANQYTLDRASTEPQETPICKELSLLGDVGDSDEELLVSPSKPLVSSPSDVNIGRELFPTPPSGADLAHGSGYEEASPVGYFDPVPVETPVRSQNDKGEQNRENDKREEAASVIQRSFLMSTLTSAIEHNTPTRDHMRRALSSPKSLLWIEDDPWLFKDPSDGFQLWVGSGDLIERNAARLATHNIVKAYLNGLRKYRRTKLATLIQSNFRRFQCESEYRQKLWAIVGIQHGWKAFKYRRMLKSKATKIKSAYKMKSAKTKFQTMKFAAILIQNQWRSYHATREYLKAQFLAVWLQRTCARARGQRQRFLALKSATASLQYRFRVYSTKKQYKLEMLKATRIQSVWRMSCAIRNRMLSIYFTCKIQALVRSHFKSRKYLGLRSCSITVQSALRKHRALRTYQQQRYGFVKVQALWRRYLAARWYIHQYQSVVRLQALGRMQQCLCLKRNALQAVVVIQRETRRLLAERAFIIIWRSILVIQAQQRRHTAQNAWFKTKAASLCLQSVGRAYISRRSFEKHRDAVVKIQSHGRSYNQRRCYKAARRDVILTQSISRQWLAHKSWKKSRAAAVSCQKTIRCHLSSAAFRKTKTACTNIQKTYRRALAMQNWKIATRSIIRIQSFLRMIHARDAFSFAMFSVWTLQRVIRGYQQKSKFTIQRHAAVRIQSIVRCTMYKAHYTEQKKASIVIQSIARRNAASYRLNNAKSAAVTMQKSMRKLLHRASFLRMQSSAMEIQSAVRGFCERSRYTRTRNGLLTIQRIWRGATARVRSSKKYRAALLIQRFSRGRSSRILATKRADRIVALQRYSRAYVARRQHERLLHTRLLLAQSSWRGAIWRKRFVARKKSALDIQTMIRGYLARKEALSRSHSAIVIQSHWRMAFSRENYSKTRVSAVMIQGRIRGICVRNTIAGLHILATCVQRHWRGHVGRLQYAERVEMRNVEIAAARLVIQSTWRMYVARVEFGKVKDATISIQKQWRVFSAREEFELALLSCILIQAIARGAVVRTRTKLWHRCSLEIQRSWRGYLGAKRVQLLLEEERLAKVEKAERMRRVELMGIVICVYHGLACISIVVQKDFARQQCAHARTHKACTLIQSAVRGMLIRSQISNRPSGISFSNGRRREELAAATKIQSMYRNRFARKQYDAKLRSATVIQKHWRSLQACRQYGISVANCMMIQSTFRGLLARNEVKTWRKSATCIQKNWRGHVGVQNVRILRTATMEKAATSVQSKWRMHKAAKRYQKVFRGAIHLQKFWRASFWRSRFELVRIASVMIQSAIRGSLVRREVKIWNKSAALVQKTWCRYINVKKIKSLSEAILLKQSLAATKIQTINRMHVARKSYHSRLRSVLVIQNHWRSAQARERYEMCRASSVIVQSIARGSLVRNEIKSWQEAVVIIQKYWLGALARERYELCRGSCVIIQSTTRGSLVRKKIGAWNESATCFQTTWRGYRSAKKVQSLAKHSSINNVNAATRMVSPPSTPVAEPAFHLSIAEQKPENEDRNEGSPSAKTVLSLVEHASADNLNVATSLISPPSIPVAESALHLSIADQPPEDEDRSVGRPGAKKVHSLTEHSSFDNLNAATRMLSPPRTPVAEPAFRSSIADQTPEDEDRNDDRPVAEKVHSLAEHATNMQSPPRTPENEDRNESRSSAEEVHSLAEHSSTGRMKAVTRMQSLPRTPLAKQALHLSTAYQTPENDGKNERSPVENVDWDSISAIDVVHDLLNRSATPIQKVWRGASLRGSFAKTRMLSTSAATLIQASFRSHRARQLCQATLMVQSASATLIQSNVRGLLTRNMVAGRGEAAVSIQRFWRNRSLRLALLQRSMDEILTKELEDSYRTQAAMVLQSFARRQVAQELFCATRSSIIIVQSFARGRLFRMRLKNCTNAAIIIQKNLRGATARSRIRGLHNGATIVQAVVRMFLVSRLFWFLRLPRANRDMVNDAARKIQVAFFLFKMRLAILSMQSSAIILKRCIRGQLVRSAAKFALVHVNSAFHNPVILSFARVVAGNDPGYAPTYVAWRRAVTQAEKSSTIVIQSAVRRFLVRTRISRKFHVCFDSHMLLDQTLIEEEDMSALAIQRAFKGWRSLKAYKLLLENHSHKRNQAAIHLQRIARGRISRILTSSYRKKTAHISRNATAFMFEVIQRSGTARVRQLLASQSSPTSLSSSLQRIADRTKWAQREAESLASNPLPAYAIAVLKNLDTPNDPPSTFEIKKTQIKPIRVETSARLQAQLEPRRPSTPVRCNKTPMVKTAVQHNVANRKTVTKTAHDVENTRQIVVNSQSAQLKAHTKPGFDGMSLSDLRKIHRETMKKTQEVKTPVKRSTMELPNTNVTLATTTQVPKTPSPKRATNEAGKNSLFGDPNNMPSPIKKENDWDWADEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G799</accession>
    <name>A0AAD2G799_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G799"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47100" checksum="67DCB2F5622A8B88" modified="2024-05-29" version="1">MIANKKTAATPTSSSDLEELPTELLLQIANSMLNPAERTRLSSCSQRLQKLLPQYLRVKILCSRDDDGGAIQQDLFVSCAKSSSFDQFLTSSENLRYGQEYYFWSFDYQRGNKAFLGRHTRHAHEPSDANHHSDGGGRLQYLYTIGLRPCTPNQTWKVVGGTDGDMVMWGEEIALTVGGLNPKPRQPDSNQRGTLCCMPKMANGPVWIVLDSHHNTSGDSGSGSCGSDDTNNSIRGGESSKLKLMPCNQYSPSPKTPEKELIVHAIPRVCDEGEYLLHSPCSTMHGSIHSDGFHVIVDFTFWIHKGIMYFGSPVLPFSLGIPILETDILDNGACPLANLLNIKSARWGCVIYYMAVAADVGEGKNLNMQRFLQRVTEHRDHQVIVNESKDLVYINVLHKRVKTMANPIPRNDDALWRFILSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7E0</accession>
    <name>A0AAD2G7E0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7E0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="998" mass="109774" checksum="E2DECA56D426B4B3" modified="2024-05-29" version="1">MTVPLEATSLAKEALKAADDARKAQQRLQMLKKRYGMMKTKGGATTAATRSTTPTKQVEEAPVPIKNVIAPPSPIKPTVVDVHKQHHDHNHHEESSTDYTVETRGTGSVVGSVATHENNHESNYENNHESNRIEDALASLGPPPPPPPPPKVIRAVSPRNSSEETSGPADETRCDEQEVHHKTSMMTSQTKEAEIVAASRSMETEEREEHAVTEKDETKVVVEQKQQLASKEPAAAPIESATGQEIDVDESSTDDDDSHGAAVSEWTEPQPQDEKQTDTLLEEARNEELPTPRLPQEQPTPVTTQAPREVPEEKPVESQPIPEPTPQPSATVVEEQLVVEASPKQEVTQKEVRQQERTRPKVFSFYEAQTALPVVQEGSEDSGHSREEAELVQPVEMAPAVEPVITMQEPKKEIPSSNPTAQIAKKKEDPQEAHPLVTTVQPNQQEALPAHHRREASGVTRPAYLEASAIIDGVETGPKPTSPQQQPVVRQQPVGKAMPAMAVSTPPASRYYVASETLQPVDELQQRVAAIPETKDDVPAPHVHENYGAYHHPYQFGDDVSVLTEHMGYPKQISPRHVNREPIAEEPLMYQEPIAEEQLAYREAPMPMQMPRRPVNEESSLYGDAPEMDMRHQGHQGHQGHNQGHQGNFGEAETPRFRNSGPLSPRSDPVGQLEPDQNDPRQPDLQDPPQINTRQFDHEAGRGIEPSEIKMQPLVSHLRGRAEPEARNQRQRNNVPRPNRRVQLSVDPYSPRQVEAPETVSPLSASGQSTAGRYPQSRAAPLGYNTPYGGYASGSPIVSNMPQVQHRYITTRSGAASVASYHRNYYPGDATVMSHQPMMHSHGSGSPMHYGGGRSVSSMPHQHPQFFPPGGGGHASFHEHHYVPSGAGSVAPSTGGETIISVRTNARGNRVVKKLVMVEEENETDPVVAFCDMMSIDKMCGIEFDEQYKVVEEELPPEPLTAADVGRNAAMGKKVFNENNYTDPFAGRHNDSSLCGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7L6</accession>
    <name>A0AAD2G7L6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002220">
        <property type="protein sequence ID" value="CAJ1965736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7L6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="99" mass="11161" checksum="5A45248666789F29" modified="2024-05-29" version="1">MDNSKVLILLSKFSVGNTKAEATLQAINIAGNGREAFKALCTHYEYKGILTSKIVEAEHTIKELCCVGEIPKMNLSMFEQMLKKAYAAYKARLQKHFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9R6</accession>
    <name>A0AAD2G9R6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS22357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9R6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00298">
        <property type="entry name" value="ACD_sHsps_p23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="92"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1966774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="211" mass="23946" checksum="BB7D27305561DADF" modified="2024-05-29" version="1">MPSAEGDHPKEGESSKSEGSSFFGRLFDHDPQKLEEEIHDQLNAEEIQPRRTIDDEMDNLFQAFAGFGSQRQDPMTEHDSFPFPAAAFQNAFHGGFQRASYRMHQDNQNVYVEFDVPGTKKEEMNLEVVDIPSCVIEFGQSANRRPTMEGDARFRQFSSSSFSQRLRLGPSVDCEKMSANLSRGVLRLSAPIKEEKDRKPVRLSIPIDEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAX6</accession>
    <name>A0AAD2GAX6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002362">
        <property type="protein sequence ID" value="CAJ1968099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="86" mass="9757" checksum="E1ABCFC75A097686" modified="2024-05-29" version="1">MTSFETNSPFSYVQQGKDILHEIVFYLPGEDGADRERKAKVPIYLGNTKNLESFCTMFLSFKNLCKHWSLTGNTNAVGALKFALFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBV4</accession>
    <name>A0AAD2GBV4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002402">
        <property type="protein sequence ID" value="CAJ1968728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBV4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="800" mass="89463" checksum="67E7EA932F6B3652" modified="2024-05-29" version="1">MTIHLRQNQPSKQYAQDGDASSSSLLYAASSTTASWKRSVAVLVMLVLAGAFFVFQFQDASKAQELEQDNKFKFEESKTTTTSSNNENHENHNDNMTSNDRGKPTTIDIQNHLRQQQDETEAETTPTPATPATSSSGSIRATATPDAVNTPPPPATTTTTTTTIKTENKKPFCTLDCTNLKQKRTAEFGGDLSNRHTMLALAVEARNKMVASIQLHYGDYFDAIFQHGFRPVSETGKSQQGLLRKLQIKALEVQTKFANEEALCQQDCASVLNPNYPLPFYHYRNYQTATAATAAAASQQQQQQQQHSNYYERYVWATGGHSASAGHGNLFNESYTAFLERDMKPLFRAIGVEFEGRNFAMGGTRSGLEIAMCFEQVFGTDLDFFAWDYGMTDGRKDSLLFHYGYRGALNPGRPAMLGVWTNGWKGRDERLLDLEQIGLPTFHRPTKSIDAMNAAFPDSGEMTEAQLQELPDYVRNFKCQGKIEKGDPYCQDDKYSKGICDNRASKAGWHPGIKQHGVDGHMLAMFLSDNLIKALQGLADHSNQDAESLLKELRAEEDELMDRIRSAHLGDEAWKIYDGGTKGGKLEDLDPDVNLKLFYKGKSICHTGRTPAITRFMGYLTNTDKVGGIAPYQSEQYDTGIEKNDADTTNADGQMRLVYEFNGKDRQQCEVPLRPDYKDFFYTHHRDGVVQLNFPNEKEKAAYKYKQSEMEGVVILILSECDWGKCKVGDLKHEDIEDGKVNIRINGVSVTKVVNIGSGCLVLKNKDGVKWEPSRNDDYEIAVDVVAPDSYLRISSVVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBW1</accession>
    <name>A0AAD2GBW1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS23660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBW1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="612"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1969348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="715" mass="80585" checksum="A5F5F6565436FC28" modified="2024-05-29" version="1">MGLSTHPEQLQNKSSKQRRRPMKMDTASNPTNKRRLIPHLFRPFHKSSSTEKIVAKIMELNNKAVTLYCEGDFSTASSLFQEAASLRQESDPWPVIELERNEPPPSSYIYQRMDFDEGMVLYPDTEAVESGDHPKSVQAKILFNAGQARRKLEDLCGASGYYERALRTFLLADLNERTPIAMITVHKVIIPILHNIGQVYYRKGNLKQAIVAYKIALQHCKSLLGEEDFSVGITLNCLGVLYYHVSVEQSQDAIQCFMKAVKIQQRVLGKNSKEEATTLNNLGRVHVQREEFDKALNFYEQALEIRRECLGKDSIDYAATAFNAGQSLHQKGDCDRAIELYQEFLRVALVKFSKNHRDVAVVLSGIAQIHQERKEYDKALKLYEESLEVGRGALGEYHSEVAMLLNRIGNFHFERENFDQALIVYKQGLKIEKRVLEKTHPNIIVTLSNIGEIYRQRGDFDLAIKLYSHALSLQRKRFGEGSAEVANTLNVIGLIYDQKGDSNMASKKLQGALLLRRSILGDDHLDVSATLTHLGTIFYRKNMISTAMQLFDESLRIRRAKLGDDHRDVSFTLYNLGLCHQLQGSYKEAISCYSETLRVEKLVLGANHRDVSMTMYKLGEAYKADGNMEQALIHFKNALAIERSTIGREDPATVARTLNEIGNIYLARGDVVPMMESFNEAARIFQEAGLSAQSVTVSGQLYAFGISVPAAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD16</accession>
    <name>A0AAD2GD16_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042032187" evidence="1">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="209" mass="22886" checksum="C58E6FB721D06E10" modified="2024-05-29" version="1">MQSFKMIRSIALCSVTALLLHLPSSHGFTVLPSVGRTPTQVSMPGVATTTTSLKMSDFGSDFASAMPEKPTLTVDERIAQAADETIATLSSALGEGVEEPPELGKLRDARKNGAPTNELALLVYELMIERGMLYDEEPETGTLTPTNFNIKEGLDIPEVKAEFGHLYKYGMAMMKTGLLTADQVKETVLERLIKRTGLEPEEFDKWLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD26</accession>
    <name>A0AAD2GD26_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS24383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002502">
        <property type="protein sequence ID" value="CAJ1970364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051169">
        <property type="entry name" value="NADH-Q_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42913:SF4">
        <property type="entry name" value="ALTERNATIVE NAD(P)H-UBIQUINONE OXIDOREDUCTASE C1, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42913">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041944277" description="FAD/NAD(P)-binding domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="49"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1970364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="574" mass="60444" checksum="14D0E0712EA57AF7" modified="2024-05-29" version="1">MRLSHLIAISYIALAEGFLSKISQQIPSGGLTDFALHGTATTTNINTCDVAIFGGGFGGLYSALSLSREAQKKGKKLDIAIVDPSTQFVFLPLLYDLTVGTATSAEVCPTYKDILKGTGVRHIQASLDCFTSDDFQSATLFLCNHNNEISNNSTKLELSFRSSILAVGSSPESTLASVPGATENVQPFYTQKDAKETSRILEDLEDQAIGSMPKTSPPKIAIVGGGYGGVELAACIKRRIPESKVRLLTRGPPMKGTRAEQLVDKALLKLGVEVELSSVQEITKGEEGNDIFVKRKLVNAGDDDNDEENDKISKEPWSVVFWTAGAGPSSPVSGDMDGLLKSDSGRLAVESTLRCISNNQQSSASSSFPKRNSVWALGDCAEILVNKEYAGVVVPATPKTAQAAMQQADIVAQNVLAELTVNSEAASKEFQYQDLGTMLSLGGPNAAVMAPIEESPLAPVFKPLLDTARLGFGFADEAFVNLSKSPLVATLGLSPVVDSIETLGLSLGGYGLGVDSDTSPGTLSGTLTGAARRALYAVRMPTNKQRATAAASAAISTAAALAKEAAQNLEKQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JG97</accession>
    <name>A0AAD2JG97_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001716">
        <property type="protein sequence ID" value="CAJ1946867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JG97"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="195" mass="22822" checksum="B3EDB314A8994E5A" modified="2024-05-29" version="1">MMYYWFELDDASKELCTIVTPYGKYQYQQMVMGLKPAPAVAQYYIEKTLHGLKEQGVEVYIDNVGLFSNSYEEHMQLIKTVVEQLQEAGFKINPLKCEWCVQETNFLGHWLTPEGVKPWKKKVDAILKMDVPCNITELRAFLGAVTYYRHMWPRRSHLLQPLTALTGTRTFQWTDKCRQTIVLYKEVVPRCPSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH83</accession>
    <name>A0AAD2JH83_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH83"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="118" mass="13415" checksum="16A05CEE38625D29" modified="2024-05-29" version="1">MTSGDEPYSAIADIFNKAFQKVKGAQRLESISSAIRNDFVRDELQLLSHLIPSLKDILGGSSTTTEPVVTLDYDELENGLERLKYAFRALTRVFCAKRFPQSFSSWMTCIGQTYRHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHS0</accession>
    <name>A0AAD2JHS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="256"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="364"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="480"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1629" mass="186837" checksum="D3FBE974E48C08A9" modified="2024-05-29" version="1">MNLLIRSEGSDSVEETDADGTDLRRPLHDSFPQSKEPTIQQIASELENGVPVRDHRWRLRIYKNCFIGTKCVDFMVRSQLVENRSQAVELGRRLTTELNLFEHVTQEHEFKDEHLFYRFVEKERRTSPGETLEFDPEVLPDPSLERLGEQLKRDLEVKKYQMHNMKVYRDCFLASDAVTYMVEEGMTNTRQDAVVLGQRLECDLHLWYDAHQKRKFHDEHIFFRFQKRMDKEDSSRSSGGFRSTSKSQMVQVANLLKRGLKVKNRTYRLKTYRKCFIARDAVDYMVSEGLCSHREEAVELGLALQHELGLWHHVCDDHEFCDEYLFFRFSATYNRNESDFDESASSSLTGSRHMHDFADIGPLLLRGINVKDRTFKLKKYKNCFIGFEAVDFLVQAKVATSREDAVQIGRKLMADFDLFHHVKYENNFEDDYLFYRFSQDHTLTSSQDSFEPGMSEELSTASSNLSDFGKEELIQIGERLRRGVRIQNRQYRFKTYRNSFIACEAVDFLVQSKIASSRGHAVQIGRQLEEELSLFHHVSKGHQFKDEYLFFRFDSGDVNHDIIAKTLKKSISEFQDGLSQFTEALHIEYDSTLRREEAKQMKYVYGKVHDKVCTLLIEGPSGSGKRSLVTTEFADNPSVLFASAKCEANENAPFATLRILLSDLCKQVADRLQIQEKLVAEVKQIHQVSLVTWIPEIVSIFPEAADVVASGNEVPTFDYMCLMQALLSFCKITCEFVPIVFLLDDITSTPACTLKVLNFLLKGCRNNLLLCITQCEEVGEKHHFTLWKSEMEEKIDFEEMTFRNLDEQQVKTFLARTLHREPEDIESLSVLLKERTHGNFFFLIQLLESLQQKGLLSYDFAQLRWTYSVENIRKYTDVSDNVGKLLAARIWQLPRCVEQTLKLASCFGTTFDPEILKATKSVLFVFDDISYTLSEACKEDLLVRISDREYKFAHSEIKETSYNLLPKRDERRRIHWELGLKLSKKRSLITDQEMLFVCVDQLVQGQSIMIVSCNDDMRSNLAHLLYVAGQNAIELSAFVVACKYLKVGMNLLGKSPEDAFGSHYDSAVQLFTAYAKATLSVGFISESRDAAEAVLQEAKRVEDKREASLTLFRCFTAESRMLEQLDFATEVLESVGHKFPKEPNGRVVRHEWEKAKAGIKSDENVLSLPHMTDKTIDTCYDILTDLILTSEVTGSAFGSYATARMMLMTLRYGLSKFTPLVLVLVGMDFIANSNDLKAGNRVIQLGFRIQSEVDLAVKGRVLTQACMAEGCTQPISNCMYLALDGYKASMELGDIQNAFHGARVYLWSFYCSGLPFGPLLDDIEKFARQMLEYGQHYIFHMTIPLFQMLLNLKGDSEDPHNIEAGAAYEMTEVKHSIENTDRCWEFIRSYGMELAFYLGDIEKATEYYDVLKDLDMGFRKASILYHTRVFFFALINIEKYRRTKKMQFKSKATKLTNFLRSIVEQGGVNVNQKFQILQAELSSLAPRDISDAIRKYEKAIVLAARTGFLQDSALGNYLCAKFCLSNPASIDSAQRFLTEACEKYAAWGAVKVAASVQKRHPEYFPEGEYEMLSPRRKSGGGLRSRTHFRPSLGDMHKSLSTARRLRDTSKAGDNEGLGFGAFAQFPFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIU9</accession>
    <name>A0AAD2JIU9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="362" mass="38988" checksum="AA4807724CE52471" modified="2024-05-29" version="1">MSTNPLTTAAAAAAAGSSSSSTPTTSRTAMNATQTQQTATTSKTRTYQHSYPVVPPPPPTRQERSRAAYDEVVQALSVDMPLIMHASGDPGEADPDSVRLLSELTANYIGNLVHAAMDAHAMMHQGHQALPPPPFERVKRRFPPTSETGSSAPYPSLTPEDAAKSGSAAAANATDATTSTSTDRKEAKRRRITGDLFDEPLPEPKIKKPTSANSANEADDEEWVGVQGVDLHESSRTRTAYTAEAISTAAFIFPICHDPGLYGRVMEVQQTARRSVAPLLVDPIVQAVVAEEGKEMGRRIIKAPKKKKKEAVPEGEENEEDEDEEHDTEALEEREQVQGATWPGLESLLPVHVTADFKSEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKA7</accession>
    <name>A0AAD2JKA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS17360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001989">
        <property type="entry name" value="PRK00784.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="COBYRIC ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343">
        <property type="entry name" value="DETHIOBIOTIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobQ/CobB/MinD/ParA nucleotide binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="CobB/CobQ-like glutamine amidotransferase" evidence="6">
        <location>
            <begin position="332"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1958806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="66514" checksum="DC443BFE0CCC133F" modified="2024-05-29" version="1">MSGSPRRSKQHKPCKSIAVLGTMSDAGKSIITAGICRVFSNHGVRVAPFKGQNMSNNAAPALIPERDRREPLYKAFEQVISKKKAGSKSKKGEGSSSSSLNASKSEEQGYGEIGTAQALQAEACRLVPRVEMNPLLLKSGGKNEKGEYMCSVVVLGKQIVRETYGDLGKRTGPMKEMILQSHRALAQATDASVIVLEGAGSCTELNLASRDVVNLSLVRALKCRWILVANIDCGGVFAQIVGTKACLSKEDWDACAGVIVNKLRGEAKYFEPGPSILEKMVSKPIFVVPYLYNLNLPEEDGLGIERRLAWETSGTVPNPTGPDANKDYKKPTVVVVAYPHIAIADDLCPLENDPRFEVQWRRRRIPARPYPDVTAIILPGSRLTQLDLKWLHDSGWAKFIQKHAAAGGVVLGICGGYQMLGWSVDDPHNVESSHSSDNKDVAKNTSRPGVGLLPIETTLKPAECKIVRPLKGKLLPSNLPVNGFELHCGISKIVLGSIPTKPKDTAPLMEFENGRPEGMVHGLNQNVKGTYMHGILRQAKAREELLVPRKEDYQNLFGINESSTESIKVEDPLDRLAKHLESCGLTYDTLQSMLQPQEEKSRKSTPVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPP9</accession>
    <name>A0AAD2JPP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spore protein YkvP/CgeB glycosyl transferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055259">
        <property type="entry name" value="YkvP/CgeB_Glyco_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13524">
        <property type="entry name" value="Glyco_trans_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Spore protein YkvP/CgeB glycosyl transferase-like" evidence="3">
        <location>
            <begin position="459"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1967747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="598" mass="67599" checksum="2EE79D585BE0FFE6" modified="2024-05-29" version="1">MYTNIRVTGRSWRRERGLPSNFDLAVLIIVAYGVFITLTGFGMTKRISHFDRAQHDFHRRQQHRPRYKKITLNKMGKVTAENSVGVMKPLIPKASDAESIIQTEAGEDGDTNKEESEETNGSPTEESSSVDTTPEQTAITKSTIVQPKKNVGQPIEKSYLAIPGAAAKKQSPELTGDANRLQWYDVIKNSPMYDEIPDQPLKVGLITRDLKAGPTNHVMMDGMRNSNHLELTKICYVTKKNGCGLMAEDPSIDLWLIDANGIKTKAKPGDLVHQLLDVVNPHFQMLFIDYSDRFVPKGGFLENHYPDVPATKFEQGHIRFAIRCIVKSRIFRVKTMPYVKLGTLVSPDYHDNLSTKQGLPFHAPFAVRTDFVNSIQDLIGSLVANQTSVKTNPSSIPYHPAFVMERPLDVTHLWEVLLPSKNNDLRNLVTEKVQAMSNLPHPLEKDRKIVVDTSIQGDRAHKGRWGVSDAYATTLLHSKIVVVTQRDQWEDHFRLFEATASGAMVLMDVMLSLPHSLQNGESVVFFTSLEDLQEKALYYLEHEDERIAIARKGWEISMEKHRSWHRMEEMLFGRGVTDTRIEDSWNPPPPPGGENNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU69</accession>
    <name>A0AAD2PU69_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU69"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="594" mass="68047" checksum="96F40B2148216308" modified="2024-05-29" version="1">MTNYITTFVNQESLKSISFPKLPRMSAITQQQQQQPVQETIITGLVCAVAIVLLRYMVLDTYRTYQRLCRQWNRRQPPISILRRPEGRSRKKNRSWLGVFTRKRNRVRFAKIFRRTFVPNEQELQSRRECWGLIQWRIQLHDEVIPEIENTVRFVPHTPVSILRPSRQDWGSPKPTSSSRVQFAPKTRRRNFIPDEQDLQSRRQLIRQIDRKIKRRNARRLMIDFKPTVLATIIEDPAEEDLSDIDSSLDTGSIDGKVDSEIIAIALENHRQMLPTVLHDMLSNIPVPMDLDDDNDNNNEPCMEEHAPLSLKRTAASCLISSRPTKRRKMNSSSTVPTCAATWAKRTNELFTPLLPVIIEDPEEDGAESHIDSSLDAGFNDDIANERSTRLAKADAIWVKKAEKILGEKANLNKMTKAERARWAKKARARRSKGQKEEMSEKEIDFEPTLLVIIEDPKEEEEEEVDDVNEKKEFKPSLHVIIEDPEGEDLSSIDESPLDAGLIDDDFDSLEQDGSDGEIFSAPTEQSDNTATNDIPSDEMGSGWTESGKRYSRRLQLKLSSDKKDPSTEALGSGMTEKGRRYSRRVVNRGKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUC0</accession>
    <name>A0AAD2PUC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="294"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="619" mass="69689" checksum="0F6AD6AA05835689" modified="2024-05-29" version="1">MKLSRSTRLSRPSFKVGDGKSHNERRDSSRARVENDDDSRDATLRYHDTRDITDSRRESDESRDCDVSSSGGSLDDQIPFLSESDLPEEASSPKKRMGWGKKKFKGFPIIATIKKKIRRKKSKQNERNMNHLEIVPDEHVASRAKDPEPTQWQKFMDSVAFPENQLGKLYSNFVDYVSNHEKTTPETEIMNYDDFVSVVEERQQSKREPLITDKQWENFMDTIAFPEKSIPALFGATTTNAKSNTEDNTKAIRALEPIEKYSTGAAAATAAADDDDDDEYEEDEQTKDSKHPVNVTMFKKTKFETLGLCPQHVYGRTGIYIVDIVEGSKSANTKLRSGMKILTINGKPCPDTVERTINMLSNLEGYVSIKAVPEAPYSAVSSSIEDIAFAMRYLFTGGGIAEEDNKVSGDNSTTTPYVLGDDSTIGTNTYREARAVARAKEQEEDDDVDDETMSMSMSENVSIPSKKSNTAVARVAAAAPPLKRMTNEIDYVELARQQQKHYELVFDIKKRRGEWVGLSLMRNADWPGVYIEHIDPRSKFASTQLAHGMKLVEINGQACPDDLRQAIYKIFDTNGRLELTVEDSDGLYCHEDGSVVDTLSHDDFRENYGGFLVQKLRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVY6</accession>
    <name>A0AAD2PVY6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVY6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="956" mass="109397" checksum="FBF41AD562E5326B" modified="2024-05-29" version="1">MPSPNRKKTPPRTATPNRAIPLRPVALIGLLLGATQLAFVHNKAMKPFQHETSEVDILHEIPTIRDLSETSKQIRNAPEHHSAKTDSSADRKADDANKPRPIATTAKPTPQPSEVKVKPIVITNPTTETTTNTQQIATAATAGATKEPLPYPPQHLTDILQETTGTKYQKAKKSSKHDYLKMKNRNKNYVPGYYPITNSNNGVPVKYPPFVHVDPYPPHYQPLLSEFLVQQYPLHPGHDMDAVVLASSPDSTLAASIHNLYHLQGFRRFIFVVDNSTKTCPQVFDLLPQHGGEPIKRTIRFGDGYGKGDGEGDDSSSDEDEDSSEDTPEEIEAEKRKNKPFLEMPTTYDPRKKHVCLSHTDFYTPEQVQILMDPNGRYSNIMEGPPTKVKRGGKMYANPRMGWYLQQFTKLLIPRLIPDLSSQYFTIDGDIIPNRPFDYRKFNYRSEELTFVMPQVYNDQFHCRKFVDEVFPELVGTRYHPKATNVVGWMVIDREISDAMIENLDRNMTNVFGYQDTFPFNVLQYANELIKEDMYFSEYFTYGLFALDYDKRNEDYNHKIVIQEFEMPARNQNINKSCLMNRKHYIQVQKHITLPPWIIWEMHKYTRFNSCPDDDIFLHFSTVGIWHDFHKPPWGGGNQFLLALRHGMDEVGVRVIGKNDPDNGQQRLLNESQIMLANSITFKGDTTPLDNLKAANNLGLVHRVDGPYYVARYFKALNFTDEQGPGPLDKEDNATRKINRRYACSTIFQSHWSMEANIKIGLDLRNPVVIPNMIDETIFYPPKEPRAPIEGRKIRIVATSHSDNQRKGFDSMLWMDENLDFDRYEMMFMGGYPKWFTPKRLQIVTANGSAAVADFLRSGDIYFAPSRFEPASNAVSEALACGLPVLYQQGSSHGDLVGEAGLGFKNVGPALLKSLDKMVENYSKHFDAIYVPRMEEITDKYLSIMRWCFYMKRLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXP6</accession>
    <name>A0AAD2PXP6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="639"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="376"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="936" mass="106825" checksum="DA7F8AA99E5E96B2" modified="2024-05-29" version="1">MRRHSPDNENDVEVTYGNDGRRSPKENFYQFNPFGHSEDDDVEEFFDENSYNEYADDDENPNRIFFDPKKTAVLNEGVHEIPGSPWAKPANRPSTRPTEPLQIARYASAIAFTLTFGWCISIFVLAIWNYSSIGRIIVEVILGILSFFGLFWNSYFTVSSIFKCFIPSRAFKTNTKYCSMIPEEKAATASWSNVTIQIPVYKESLQEVVMPTLKSCMRSRDYYMRKSRARCNIVVCDDGIMAFLKNNFAAAEMLWETISKTDGKIFKLSQLLQRVPRPSRRHLKGLKSHSVYEVFHRMLFYYHYDIGFVARSTWDRRGKFKKASNLNSHLRLVWGAEQVAKTNDFSLEQSFLEVSHNSDGSRDTMFGNDISIGHLIIVNDADARMAETVILKTVPEFLNDKFLGFTQHATKTLDDQRGESYYINMLSAYTDALYQGHFLLSSILGCHPPLVGHSIFLRSEAVKQCGRIRTLRKTQRWLHNIGLPFLSVDQVGLNNLQDHGSTEYWSECHVSEDFELMIHLYNLGFNGRYVAYPDCEFQEGITRTFDEEAGRHRKFALGGHELMFNPINSWIGQGIFSPLFNTFLRSDIPSYYKIFLTAYLFSYTSGGAYLLVFSTAAIAKIIDKESEVSYLMAFNSAGVLILSIVVYYVIGYSTFLFSMVRMHMINKNLLFPKYRKRGVCHLIYKMVRYSMLFQILFYTVMGNYFFLGSMDHLMSKSAIVSATNKDTIHISRCTALWDTLRFNSGSLMIAFYLLCLSYVTVLESMDWDYTAIPTGDDLLSNALFAGPPALMALFAVVVPIILNPYILGWPFYPPFGGLCGKKKEVSGRDDWKLSKNKRTKSGKVVDLNTFMTSVQAEQKLEKEIGRVQNKPDVELGSLATYEQGGRFPMSVATSPYSPETTRQLALKSSSQPLIQRAHSGQPKAKPRRPNNVKAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBJ7</accession>
    <name>A0AAD2CBJ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="128"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="202"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1924014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="284" mass="32231" checksum="19DCC0B7F4CB9D43" modified="2024-05-29" version="1">MHTPSFLNVHPLFLESVVFSIDCDPCQQSSFAGTKNTTVIPDPTPIGPSGVEKVSTLSIHNTPLASDPSQINALHQLFSPFMLSNHQLIGSSGIRALPEGQQSSSSPKVRVGGCGAATPQAQYGRQQTAKWNKRYGELVQFQKEHGHCLVPVHNYQNVLLANWVKRQRNQYQRKAIGLHSTLCNKRQRALEDLGFVWDAHTACWDERYEELRQFWKDKGHSRVPKNYKANPSLAMWVKCQRRQYKLLKGKILSSINAERIRLLKDLQFEFNPAARTSGSQQVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC37</accession>
    <name>A0AAD2CC37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1919798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CC37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1919798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="197" mass="22506" checksum="81E643C638FA4271" modified="2024-05-29" version="1">MFRSRTPPSSSRSRSSRSTRSARGSTKSRRAGSRGGFADRIRRAAESGPTRKWVKVMRSPAPRIRFQVTKWIPINELTEEERIEYDREQAAIQEEKQKQQMQLQQEQQQQPQGDEHQDQKENEVKEVASTPESCKNGAPSFEARNVDSSVTNPQLSEEQTSAEKGEFPHSSTAPADEPPTKRTKFDEQVQVEEFPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCG2</accession>
    <name>A0AAD2CCG2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1910824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCG2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042034152" evidence="4">
        <location>
            <begin position="23"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1910824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="454" mass="51235" checksum="EF8E0A1DFAD6FA4E" modified="2024-05-29" version="1">MNFSSSILVAVLLALSAGFVQSEEEEQPITYGADVSYPMQHEQASKNYPWLPWNKDPNIPVPEEYEGMPLQPLGNKQSFYDDLILGCYEYYGKKGKRCLETEKDRIAMTLRQPKSMYNYTKLGYTKIRAPDNVFSLIKEFWDKNKGKEKLERWGIGNTYTNHWDVPTHMLSIEDENLENGGYVLKQHIWNAARDTISAWTGQQLAECSLYGIRIYKEGAVLAPHVDRLPLVSSAIINVDQDVDEPWPLEVIGHDGIAVNITMLPGDLVLYESHSIIHGRQFPLKGRFMANVFVHFEPIGAVGDPMYLDPDLPGYIIRGSEEEKNWRKNNPDGYRLVEGKFTTGSTDAHNAAGLGKHEEVKRILQEKPEYVNHRDINGWMPLHEAVRKGHIETIAVLLEHGADINARTKNAGRGAAGGSALWWAIKIHGEDSAIVEFLKQNGAQNFAPNEGNHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCZ0</accession>
    <name>A0AAD2CCZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adhesin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094:SF1">
        <property type="entry name" value="PROTEIN FAM185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1930254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="55924" checksum="7CD35F627DC2E861" modified="2024-05-29" version="1">MGRKESHVMINLDPKDAIQIEKESKQPLSHPRARDRVETKRVILDDGSIFPDSEHWSNLPEGFRRIEYNDDITHVKEADENVEEPETLIEVDVPEKVNLECDLVNGGSVQIQNKIEGDVRIITADGDVVVQKVRGHTIEIQAFGQGNSIAATDLLEAESITVNLPNPGRLRAMKIHANSFEAQIGEDRAQESEQLTTEIFGDDDTGAVCDISSLYVTGEALINLISSHEKRQAVRVKSNHGHVVVEAVGIQSSAKNYITGETLPTVYMGGVNGSCEVFIRGDASKQNGSKWTSCQVHFDSISPQSVSVVQADVGNVTVTVDRKVETDLRMLASSKVSAVDIDALVEEDTNDGLSSDLKGRILVLDNSVAAGVRKAINIKTKAFTEREIDISLQNSEYIDGWLENKSEEPDSRFDRKTRGTADGSVGKIRLEGAQDQALRGFQDKEQGTNIFQRPLLLVTSAAEITVETLSWLGNVARRYGLNDNRDKEMLGRTATRRGRSFVHPPGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD65</accession>
    <name>A0AAD2CD65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS1938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD65"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="78"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1930431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="188" mass="21247" checksum="AC5406726A75FE47" modified="2024-05-29" version="1">MLHKTKFPIFTKEECERIVNEAEDIASKIEWTKNRHGNFPTTDLPLVELPETMRFLRLALVERIYPMLKVQFGEYLPDPSKLRLADGFVVKYDAAGGQKELKPHRDGSVVSFNIALNSADDFEGGGTWFASLDDAVKINQGEIVSHSSALLHGGHGITTGKRYILVGFVILEGYDSWSMRFYNQVRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDL3</accession>
    <name>A0AAD2CDL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS1109</name>
        <name evidence="14" type="ORF">CYCCA115_LOCUS1118</name>
        <name evidence="15" type="ORF">CYCCA115_LOCUS14900</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1925023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDL3"/>
    <dbReference type="SMR" id="A0AAD2CDL3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="12">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1924876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1925023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1954308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="103" mass="11383" checksum="84E4A9C498B9758F" modified="2024-05-29" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDSVTYTEHARRKTVTAMDVVYALKRQGKTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGU1</accession>
    <name>A0AAD2CGU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000302">
        <property type="protein sequence ID" value="CAJ1933782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAG-pre-integrase" evidence="3">
        <location>
            <begin position="262"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="886"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1933782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1384" mass="157993" checksum="42239E3E3D170344" modified="2024-05-29" version="1">MNTSLIFEHDSVPVGIDSCTSATVCGARPMFIGELEPVLGLKLEGATNTSIPIVGRGTLLLTFVDDAGQTHQHKVHNAYYAPRLKLTLLSPRQWSNQGPKKGRSADPVRTTVLRGDKVELHFEKDCIKTIDYDAQLQIPLLMTKPGYKSFSTHLCSQHLTAREARIRPTALTIGNVELPAGSVLRHQEDRELLNQEMDNKNYEKDPFDLRGETAPILADTIAGAFEEPALEDFNFESILSEDWDSTAPEARLPSLNETDKRTLMLRWHYRLGHMPFSHLKASAAAGLLDPRLATVQEHPFCPGCQFGKATRRPWRHRSKKKDGSRKKLRQAAHPGDVVSVDTAESRNVPGLVAQLRGRPTLMRYHYATTFVDHFSDLDYVHLHQRNDGDSILEAKLAFERYAVIMASEKRIRDIRDSARSMLLLAQHNWPAAITANLWGFAMIYASQIRNSTLREGEKRTALQKFANTDDRPDVKQFHTFGCPVYNLDPKLQSGNSLENKWCDRARIGIYLGLSREHAHSVSLVLNPDTGLTSPQFHVKHDERFETTKIPAMRNVGKWQGITRIHETVLKPKRARSNKRTKLSHTPVSEPIDTTQTPTPESNGENGAPVQESMGAHSIDRNGQDRLGQPERNGQDRLAHDRNGRDRLGQPERNGRDRLAHDRNGQDRLGQPERNGRDRLAHDRNGQDRLGQPERNGQDRLAHDRNGEDPMHTQQENEQLIQRETPASSQRETQSDPQRETQLFSQREDGSASQRETERVSFQHPALQGTVNSQTQAIQALKAHKSSSQKRKRGREEMEETETATSLEEHRREMQLTIRCYKTEIAREVHAEELVEQCMTSNPFAFAATLADEDTMYLNQAKKEPDWVQFHEAMVKEIQDHTEGKHWEVVPRSSMPEGHRAMRGVWSMKRKRRVGTGEVYKWKARLCIDGSSQEKGVNYWETYSPVVGWETIRSLLTLAILNGWTTRQIDFVLAFPQAEVECPMYMEIPKECYVDGSELNENNVLLLKKNLYGTKQASRVWFEFLKEGLEEIGFVQSSEDKAVFYKGETIFVVYVDDGILMGPNGREIDDVIGQLGHKYKLTDEGDLNEYLGIKMKRTKDGRELTQPALIQRILQTVGVSLNRGDRQEVKTPATKTLHKDEGGEKRRMNWDYRSVVGMLNWLARSTRPELIFAVSQVGRFMAFPKKSHEDAIMRICTYLRDTRDKGMIMKPDKNKGFEVYADADFAGGYNKHNAEDPATAKSRTCYHIMFNNCLVYSHSKLQTEIALSTTEAEYICLSQALRTVISLMRFFKELAKKIKSFKYKRPRFKCKAFEDNNGAIAIATTENLRPRTKHINIKYHHFKRYVRKGYVTIERIDTIDQLADIGTKPLLPHMFIPLRKALIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH99</accession>
    <name>A0AAD2CH99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS3149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000236">
        <property type="protein sequence ID" value="CAJ1933075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1933075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="262" mass="29739" checksum="64C2510D3956BE95" modified="2024-05-29" version="1">MPLFPYKLNELLTEMQSNARLSPIISWTHSGNAFKIHEPLLFEEILLQKYFPRQTQINSFKRQLLYYGFDNLGNGIFAHPCFLKDKRHLCGQINHTNPTKSQREGKALIPSRRICGKRAKHALTQRLKVSRAFTKAKNTSTKKKQTPQMIACDVSSFKTSTAAPPQSLLAVPLISPLVHSREIQNQYWSRWMETPCVPLIAPFKMLLLDLPKEDQNLPLLSTGGSMLPPMNRLSGGLSQMDRLAVSLPQKKLDSLVEEQSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHB4</accession>
    <name>A0AAD2CHB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000247">
        <property type="protein sequence ID" value="CAJ1933145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1933145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="508" mass="56507" checksum="E2B97F8961AE85CB" modified="2024-05-29" version="1">MRVRKSNPRRILYSIFVISILSSGGKRSSPTYFPVANGLNSSIKRNAKGQPRLCSVMEVSLNGFTRLCFGKATQKDITIQALSNRKVLQGKLESLQVSMKKSKSSLIALDSVTITGNDLNFGYLPLVIAASLPTLFFLLSVREIFYLALFVFLWRNQRQNLLRPERIKAIETRMERQRQKVSKFLLGEGPCRLNYQITMTNDSLKDSAWVQVLAKSLVQTFMANSALPLAAAVSDVTNNLMLLEDSSSPPSSPSNLRNAGASGGSLSTNNPKDNPILTLWKEQEEAQNDQRRRNQQQQQQQKQEAASTASPSFPLTDLFAATSFELRQAPVFAKDGHIWLPCVANLPYASNNNNNNNNNNKSQLDFTLRTKPKVASTFPQQQQQQKQQGLEFSAAECSLDVKATQTPEWAKQFLPSIVWLPIGAAGMILPIGGFNKHQLKRVTVQDDACQIQGELDLFRKKSSDGSSFMGEGRIIGKTFGNLLQSFSSRKRREKGNDTDDRPKLPGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHQ2</accession>
    <name>A0AAD2CHQ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000147">
        <property type="protein sequence ID" value="CAJ1931435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHQ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF2">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59903" checksum="2219F9BAF7EFD0BD" modified="2024-05-29" version="1">MEEPRQENNDHSLEDPSPLNRDDLLGCLKTLQRLVDGNRHGLDLLNSEERLALVIAAGRLSRPSKEETSKRKKQAKDKLASEQRALDRKAREKTGIRVARTQPVFEAPEALLLESAKEELKGNATLGSYRNCYICKAKFTDLHPFYDTMCTPCGDFNYQKRFQTADLTGQVAIFTGSRLKIGYHATLMLLRANATVIATTRFPVDSATRFAKEADYEEWKDRLHIHGLDLRHTPSVELFCDYVEANYERLDILINNAAQTVRRPPQFYKHLMDAEQMPFYEHSSEVQHLLKSHHQCLDRLSGFSTDDGNHTSSSALAVVDWNTASPGIGLRASAQLSQIPYKYDGAIQSPDVFPEGKLDVDLQQVDLRTTNSWRLTLGDVSTLEMLEVQLVNAIAPFVLCNKLTPLMQRHNTGCKHIVNVTAMEGKFYTFHKPTARHPHTNMAKAALNMLTHTSAGELAKYGIYMNAVDTGWVTDEDPAQLAQKKVDQHDFQPPLDIVDGAARVVDPLFDGINRGEHWCGKFLKDYAPIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI65</accession>
    <name>A0AAD2CI65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000282">
        <property type="protein sequence ID" value="CAJ1933593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI65"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23100" checksum="AA031FE9592D9B70" modified="2024-05-29" version="1">MTLYFDWRIPNADFSGVKSSYKEFRTLYRDAEEQLPSNMPKPRGRQVGSLAYVDASHAANKKTRRSHTGYVIFLNRAPIVWHSRRQNTVEASTFGAEFIALKSCIEAITHLRYKLRMFGIPLDEEPTQVLVDNEAVVKNSSLVESTLNKKHNSIAYHYARWNVAARVIAVSWINGAINIADAFTKRLTQMRRENLFGSWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIJ2</accession>
    <name>A0AAD2CIJ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="644" mass="71580" checksum="9D04B26CDF135CB7" modified="2024-05-29" version="1">MQLKKQRSLRGLRSIQPFSINNKGSKSLRGMRSFGRKTTTTTNPEDPTTATYYTEGSSSSNSSVGSLEFNLDSMNDKREPPTSSTGAKEVKASLNNDNQWAIFPPSPTVGRESMKSKTAPSMKLSKDSIGQQKPPVAEVSLESKKAQTYSPTSTQTVKSSTTNKIDQQKPRPSAMERSQKNNEIKSSEPKSSSTIVHRENQKRTQASQVKTPTPKVIRESRRDKNRWGQEAMSSTKKDSKPANSTRSRPAAVLATGAVVSLQTNDERASSGDRIRMAVEKYYSKLEAVKQKQEEERDYLFDDALSASEDDYTDAGYTVFSDMTGNTDGYTVFSDTATGHSRMVDIDDIIEDDEFKRATFGDDMASVDSMATGISGGEQWGTGLFDCVLLRYNVTMRPSFTALSLWKHNSVEWSPKLTAVQAHLRANTRYVLPDLPHVLTSEEREDFMLQVSPPNRVVTIATCHHTPSSLKEFSLKADTILLVGGNDKSDKTLSTSDAAILLKEQNEDISLWGVTNPNDPYSFESVNKKIDAGMEGFITQPLLSTPALDIFESYPRDADTRYVAGLAMPRSAKNLQFWLKLLDQPELEQDALFKAHLAFFSQPYFTSMAWLGRELENLSTRATLDGVHLMPMGNTEDLINVSRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIS4</accession>
    <name>A0AAD2CIS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIS4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="213"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="288" mass="33701" checksum="569ED40725621FF8" modified="2024-05-29" version="1">MNIATLNILEPRPIDTRRMIPVENLPLIQSTLNDRILLDLHPWLVIDRTDFRSSHNDSQSKKIRPKASNDDSPKREHISHFVNDTISPLVASSAVDETENGPKTQAPARKQALADESDELSAAGAPEASSDPLVFRSSQLEQWNTRYQELIQFKEEYNHCSVPLHYPNNPSLAHWVKRQRHQYRMKKEKKRSTLTDQRQDMLESLGFIWDSHATAWDERWDQLSKFRDEHGHSRVPKKYTPNQPLSIWVKCQRRQFKLFSQGKPSNMTIERIRMLKALDFVFDPRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ60</accession>
    <name>A0AAD2CJ60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS4837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000491">
        <property type="protein sequence ID" value="CAJ1935626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041933140" description="N-acetyltransferase domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="47"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1935626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="312" mass="34916" checksum="1F0D2368113E5ECF" modified="2024-05-29" version="1">MCLLLTVQSILFLQTLAFQQEKFAPSLRNRVASTMNAAANEKIVSDLTFRRPLAEDIPTCFEIESASYPGDEAASLDSLYNRQSNAGDYFQCAIFDGNIVGFVCATRCSLFEEESMSTHDPEGKLLAIHSVVVQEKYRRKGIASAMLKCYVEKVQVENIDGSIESMVLLAKAHLLGFYVKCGFQVNRPSPIVHGQELWFELEKSTVRGLPLDGQETWFCKTETFKRPFPEVKPHLEAHKDWVKQLRQHGYCITSGYRVDSEGKPGGGGLMFLAAKSYDAAQKLVLQDPLVASDCVDWQLNGWIGQVGDIQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJS6</accession>
    <name>A0AAD2CJS6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS5081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJS6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="6">
        <location>
            <begin position="189"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1936217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65043" checksum="2F54BD20B7ACE932" modified="2024-05-29" version="1">MGIAGFLAKVLETAGRPVDVRDYAQGKVRSHKRSRRRKFRIGVDLTSSIYKAAFGFGDMLGDERHLTNFGRAELLEEQQQNMVAKNDKKVDEYIARCAEFVMKRLEMLRKDSDCDILVVFDGETPPIKAKEAARRRDIRREHTRQRDAPLDPDQSDFRAAEEVRVKANRRAGAGKHFGSIVCGLIESLKEANIAYLFAPYEADGQLTYLSKLGFIDLIVSEDSDLIAHGAKAIIYNYISGNGFPDEGKLLQFEDLGEVPGKFDLSDFSPVMMAILFVSVGCDYIGKLKGIGLGTASKIVREAFLGGSVSPLATIVAQLCERSWERDLSEDKMRDYERRFVAAVFTYQHPIVFDPVQGKALIQGESEMVTQTELTKHEGYARLCRDQDQRSQVIGIVKEPEAARIAAVTPYVRKAAGPTKRNGEEKTANSPPGEGPTNLKVHNYKRHDQAASSTGKPSRSIGHSQMLLDSEIFCSHSQEIGLLTAQSQSPPPTSGSERVEAGDSQTFVESSRYETQLNSEQSQQEPEFDSTSKKDSNSLDEIGSVEQRNQTLQLGSPNLLYSSSPEKSQTQRSEQSSVVATLSPNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK06</accession>
    <name>A0AAD2CK06_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010865">
        <property type="entry name" value="DUF1499"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34801">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34801:SF6">
        <property type="entry name" value="SLL1620 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07386">
        <property type="entry name" value="DUF1499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="24676" checksum="E3D70361D7E00477" modified="2024-05-29" version="1">MSGNKMGSPLPRNELMLSRRSTIAATIGLATQGFLVISSASAEVSDPPKSFPTQAGRRGCKTTTNPSQTVVTCVGDLQVNNADGRLSRVSATENGVSTSSVKNPSRFSPPWTYLTETSDATKAWKSLQSAVLNADTNMQIVELTDSYLHATVPTQSPPGTGSLDDLEFILRPEDNLVLYRSASRTSVFVYPLTQPVSDSNTNLKRLQKIRATLGWEELGYAQKGSERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKH3</accession>
    <name>A0AAD2CKH3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000659">
        <property type="protein sequence ID" value="CAJ1937529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKH3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="571" mass="67297" checksum="6AE27D7F9DB8297F" modified="2024-05-29" version="1">MSPGGEAFKPTAASLTSNNENDNNNNNNNDDDHDEEDDTNTTTNKKPITEEKKQEHQRDLGRMRSQRYRDKQKQETDDEKKQRQRELARVRMQRFRDKQKLDEAKKQQKQGTNDDGNDSDDDTKKPILTEEEKRERQRELGRLRSKRFRDRQKQLKKQDQAREEGGQKNNNQNNNNDPEDETASATSAASKLSLTDEEKKERQRELGRIRMKRFRARQKEEKERHRELDRIRSERSRDNEQNRETQEEQGGDPPAAKRARTEDESSSKDDGNDDSASAATDPYSMPDKPTLTEEEKKQRQREQGRIRMQRFRAKQYKAKISGEVVAAKPKLTEEEKKERHRELQRIRSQRHRDKQKQDTKDEAEKAKREHQRELNKSRSQRFRDNQKRKKQEEQQGITLPAKRARTEQQQEEEEDNDNDDTAEPSQETTKPAASSESTAGNPKLADEEKKQTERKVSPTPRAKKQKQDNSTPVQQELSEEEKKERQRELQRARSQRHRDKLKQETDAEKKERQRELGRIRSKRFRDNKRKQEKGGEEEQTLSDDDDNDEDHSQKSPVKKSGKSDAEAAVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLT1</accession>
    <name>A0AAD2CLT1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS3763</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLT1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="10">
        <location>
            <begin position="524"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="11">
        <location>
            <begin position="793"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1160"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1934423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1189" mass="133490" checksum="221FB112079B6988" modified="2024-05-29" version="1">MPSKLTSEYILPSQLSDGDGDGDDDPSAERDDSSSSKSGSNIHQNHNIVAIAERENELVVRSKKLMLLTLFLSAIGMGMATYYVSSRTYDDSFTKSYSDDASLIINTIESRLQNAFKVMGMLSKIMSSSGNEVNSTWPNHTFTQFDTLASDALSIMNAEQIVYAPLVRDEERMGWEQYSMEHQNGGFDMVQIAEDGFDGASQRPEFIHGQRLNGPITREVFREKYSPVWQISPPQNDITLFNYNLLNVATFDRLVNASVTLRTGAFSELIDAQYIFGPGTVPDNHPRSIVVEPIFEEVNDRESLIVGHLVALIPWSAFLEDILSESPSAVIDAVVEQTCGEEFTFSIESRSADFEGYDDEHDRVYDKFERSINLSMFEGNSASTFGVPDDCQSILYLFPTAEYEESFQTKDAMNLTIGTLFVFGFVIALFNLYDIFVGRRQKKVYSVATKSNAIVSSLFPAQVRDKLISDDNGNQKKGKRSGDSASFDFGSSDADFWTNEMHKSTLGMQDESSPPIADLFPSATVGFLDIAGFTAWSSQREPSQVFILLETIYRAFDRIANRRRVFKVETIGDCYVAVCGLPEPNKDHAIVMARFARECLEKMNQMARKLEVSLGPDTAELAIRAGLHSGPITAGVLRGDRARFQLFGDTGMCKGKERFKRIAFSRIVSLHNWLVFGDTVNTAARMESTGLKRKIQVSKETAELIIEADHSDWVRPRQDIVIAKGKGEMQTYWLLPQRVSPAGELDKSIATSNGEVSDAFESISAAAEEGNESGTSDAEDDSADKIQRLVDYTSEILQQILKRIVAKRANKGNISPTMELKLSALEDEIGKTGICLDEVEEIIELPAFDQNAYSQGVELGSDVIAQLVSFVKMVATMYRNNPFHNFEHASHVTQSSSKLLSRIVAPKHIDEVEKLHDHTYGITSDPLTQFAVVFASLIHDVDHRGVPNFLLVNEEPALAAMYRKQAVAEQNSVDVAWNLLMDPSFTALRRTIYKNEDELRRFRKLVVNCLMATDIFDKELAALRKARWQDAFFTEHNEENQISINRKATIVIEHIVQASDVSHTMQHWHVYSKWNERLYAEMFSAFSTGRSSKDPTEGWYEGELWFFDNYVIPLAHKLKDCGVFGVSSDEYLNYALANRSEWEEKGKAIVEKIHEKYQNSFEKPSSDKGHRMSIRGGVSESAPTPNRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLZ0</accession>
    <name>A0AAD2CLZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS3853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="99"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="478"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="622"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1934513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="799" mass="90134" checksum="95330623CA6E6067" modified="2024-05-29" version="1">MSNWLTLPQLRGEADNVPGPSPAAAQHAPATWEAIAEVAQEVQKQHHQQQEEQRMRQEQQQQQQQQIELRQGQLGGAVALDGPIDPGIEQKMPGSGGSADSTYVMRIHDMLEDADREGNTEVVSWQSHGRSFRIHKESEFVDKIMPRYFKARLDSFKRWLRAWGFVRQTEGVDRGAWYHRYFVRGVTTLCKNMTRIQMLQAMENWIPTGQAPDFYKASTSLQGWYENPVPKLGAASDMDGIASTSSAISKAAKDPKRLRGRVLEDIRQMLEETTAVENEREIVSWMPHGRAFKVHQSDAFVKLIMPRYFKTAKITYFSDALRLWGFCRLKNKGPDKGAYFHLHFVRGDATQTRHLSRKQMKEVMANWPGPKGEPDLYSIQPLGQIGVLATPAAGGAMGTQQALLQTTNVPPNAGAMVGRTPIDPIEFLNMPVEGTQNPMLLNQAANAMDPNAATYPTVAASVSERQPLAPAGKSVTSGDTTYVIRIHELLEDSEKMGFQDIVSWRVHGRAFRVHNEAEFEEKIMPRYFKAKMASFQRWLRAWGFVRMTEGKDRGSWYHRYFVRGATDLCRNMSRLDMFNSMKNWLPIDQVPDFYNSGTGQVFSEAPKKEAPATANPKNPKRLRGTVLEDLRNMLEDAEQENSTSVTWLPHGRAFFVTDKASFVTLVLPRYFKAKKFTYFSDILRIWGFVRLKKQDKGAYFHRLFVRGKPELTRNLSRKQMKESMAGWPPPSGEPDLYGSEAAGLTSGSTKGLAPSTGIVGIAEALPIPAYAPGIFAPNEREAGDKQKVDEMIEPMRVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM01</accession>
    <name>A0AAD2CM01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS1223</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM01"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="70"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1926506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="388" mass="42210" checksum="6DB185B037B7A117" modified="2024-05-29" version="1">MIENTDSEIQELEAIQEEIQEEIEELENAALSRSAESPTMITSDRLRHHHAHRTNLRMKVFATLNDPRIELLAAASVILSTFLVAVSTLDNLSIEAYAAIDDAVIGLNVLFTIDFFVRWYAAGQFKFIYLTKPLAIIDLFVVIIPLFLGSVMPMLDGFGLMGDFVPNVSESSGLQVLLLLRVLRLKRVLTDIQTFRRFAGAIGIRRSDVRPYQLQLSRVLLSIFTLLSVASGLIYTAEHAVNPAIPDYFTALYFGLTTLTTVGFGDIVPVTFNGRLVVCGSILVGIAVIPAQAAKLVDAIVASQGLAEDETIGTMTRSTSLLTTKKSRGDTDSPTNGLGPSGADLEVPPKDVKMENTGNAASYKVCGNCRATGHRMDATFCFNCGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM90</accession>
    <name>A0AAD2CM90_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000652">
        <property type="protein sequence ID" value="CAJ1937468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="199" mass="23155" checksum="EFBCB7559DBAE6E5" modified="2024-05-29" version="1">MDTEIGGRGLHHNCFGGGRGHGRPSNNYQPYPRPSNSPRYSQGTSQRFQRGGNSQQQNQGRFQPRHPNNGGIGRGFNGQRSGRSQSGRFQPGRNYQGRGQSQQQNSQNYYAELHYNQEAESFAAECSVLEWNQDGMSYGGMPSAEQYQHQEQYYQAEENQQWNDQFNYEQEEYYPEEQEAHEHFSYDEDSPFSFHEEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CME2</accession>
    <name>A0AAD2CME2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000813">
        <property type="protein sequence ID" value="CAJ1939566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CME2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052920">
        <property type="entry name" value="DNA-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43358">
        <property type="entry name" value="ALPHA/BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43358:SF4">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="3">
        <location>
            <begin position="186"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="353"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1939566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56719" checksum="95B9A4E738BADC6D" modified="2024-05-29" version="1">MFNFGKQRKLDEEKKKQEDLIAAQLKALELDHELEYEKMTQKGLVKQQEQRIQKEKEEIEERQRQEKKKKRELAKKSSAVSSPSGDAENGIAIVDHDGDSDSSVDENAQPNQNQDKNYLEMARMGYQQLINAIIRPPRANYEMRQLGPSKFNFAGKAFEREDWTLMTERGYNLKVSQWSLVGGGIRPILIYLHGNASARLEVIPQLTSLLAMGMTVVSLDFVGSGKSDGEFVSLGYYEREDLATVVAHLRRLHHQQQKDTGDEVAEFKIALWGRSMGASTAIMYGARPDARVNCMICDSAFSSLQNLAEELVETARKQGVVVPNVVVSAAIQMIQWTVQKDADFNIRDLTPVKYAEDCDVPALFVHGEHDDFIKPHHSEDICEKYKGSKNLLMVEGDHNDPRPHSCIVACESFLQRRLEMKEEWKLLDVASLKHPMYPPWVQDSTMGKYKTTAASNGFDDKTMGMTTKRQQEIQSSINTMLGSGAAPSTPDAHAEQSSVEVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPN6</accession>
    <name>A0AAD2CPN6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1942138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="176" mass="20545" checksum="D990F17D80D28B11" modified="2024-05-29" version="1">MKSLHASSVDSLLNFVHNSSDHSTPLLIRKPLHDNGERKNVRFADNLEQTVSTISRDDLSKEEIESYWLNRVEMWDIECEKERIVEMIDYSLPKEKGTSYRGLEIHSGGGIFRKKIIDRHFNAVFFTQEAQKQKQKEHCDEELARSCEETSKESLRLARQFGLKDQKDAQKFLCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ60</accession>
    <name>A0AAD2CQ60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="33322" checksum="394F62F528B49B24" modified="2024-05-29" version="1">MELDDSISTSFRTPFTESLRTYQPLDESNELTIVERTSRIKKIADSRLSELTINKLKIQSIGLIGRETETERLRSCLRSMMDNQAAEDDDETEMNEDTIMISKVKKELVFIKGFSGVGKTSLARTVQQEVNSMKGGYYAEGKFDLNESKETPYAGIAKAYSQLVAELSVTNPDVLLGIGQQLCDTIGPEVEPLTYLIPELESFVTGYSNYSNENVDGMQERWRYSFRVLTRLLTSYFRPLVIVIDDLQWADKASLDLMETLIADSQNVNPLMMVGCYRSNEVGEKSDLAKSQYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR06</accession>
    <name>A0AAD2CR06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000093">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin C-terminal" evidence="2">
        <location>
            <begin position="196"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="366" mass="41808" checksum="E657260FA84BA6ED" modified="2024-05-29" version="1">MLKLTMIPRKRTKRMRAYQGKPRQQMSQMEVEQRHKEQKDMLADNLYALIHQESSGRYNCVDYLAFTSWHRSVYDLLKKDRFSPSQRGESRIDEYCREQIVEWSFRVVDYFRIDREVVAVSLSMLDRFLATCKCDRSTFKLAATTTLQLAVKLLHPCRLGDLGILSDLSRGEFDMSDVRDMENHILKSLGWSLHPPTTVAFSTLLLDYVFADRDVSMTCADIDDLHDISSFFTELALCDYFFVTMRPSAVALACILNALEGMYGERNRFSAHILAVARSLNLYTNQDLTAACHRLWELYERSEECALHNGFAAPMEDEKNAGTVGSYVNKATSQDMVMEIASTSPVSVVTKQCPIATDDIMSDVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRW0</accession>
    <name>A0AAD2CRW0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000349">
        <property type="protein sequence ID" value="CAJ1934641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRW0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="123" mass="13964" checksum="76B2B6584E05DA61" modified="2024-05-29" version="1">MPEDDYHVKSISHQKDFAGLIAPPVVLMPPDQRSKADCTKGRRSSPVVSTLSLDSMTLVSSTKQKHKAKNSLLESDEDEDTEDDDPNDRESIVDDAMEEDEDDERGKPLGRTRMMRPWTTIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS15</accession>
    <name>A0AAD2CS15_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS15"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="215" mass="24000" checksum="943AC669AD48E488" modified="2024-05-29" version="1">MGVVVIIPESLIKTILLEDGEDIMTDDGDGSETNMNIHHNPALTTRRAETSSVTDSVELLIERRPLLFNPPHPDDTVDGKNYDEYDFEEGGSDYDENDDDDYFDDYSDTEYNMPLNDSFEQEQEGRTTTASRTTDPSIIRRQSSSIASSELLLDAEGRFHDGETPSRGIDFGDDYPLDDDDQDSIEFPSFRNSQPVPRTVILPGGTTGTRIGTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSU1</accession>
    <name>A0AAD2CSU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001291">
        <property type="protein sequence ID" value="CAJ1944982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSU1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="85507" checksum="1AC2C7B8ED7144AC" modified="2024-05-29" version="1">MQHSAEQETSKEERRKKRQEEDRRAKSRGARTTTSGGGSSSQRRSDRDAKEKARGRRNRNDPPVNPGVVAEKNSSDARQKGRARRTGSGPVVPGAVSETKNKEDDARERSKKRKEKNSQNSSSRSTGGSNTAQRERNRKIKEKAAMAAVTPSAATLDQKKTTSAAEDEEIIPMAAAIDIEDEPAKQEEYAVDGTCCMAPAMSATLFASNEAAESARDQEQADEKLAATPTPFYCKAWFWLIVLLVLVGGAVGLVFGLNSSSNDTASSAASISTTTAPTNSPDKGLPPTNVPASTNAPTGTDSPDTGNSAGVPASPSDAPTSVSQPTDPTEPTDSKTPPSIPPPSMSPSSNPTDAPVVGPSPPPTVFPTATPSVTPTGLPPAEPSSNPTFAPFPGPSPPPTPSPSKVPTVSPTPSPTKMPSQSPSSRPTTTPSLRPTRAPSQQPSKGPTQQPSVVPTVAPTDRPTFAFDGQGVPVYGDWENEVNIGDDIGQYFLYVPNDWEAVFGSLPPAYPASAVLNAEQRRNDQVIWQGQMIAWTHGGSRSDIPVGFESGRRNPYSNSAIGQWETGDVIVPRYVTPNVDWRSSFNANSLSGQGKYFLYKYEEWEATFGFDPRSADAQTPAIVCRNGQQVYSADIQTWPLQTYHGGYLHARRVSGSTTGDFEQGDYLLPPNMACPKAIRSSFTSPVPITAADATKYKTTSVAAGSYFFFDNSDWEQAFEFPTFGDCATSCSVSTRDINLAFFNVRQCRNGAEIWTGLVATSASHFYYPSESRAVGRRNNPTAGDFETGDTIVPFSRSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU50</accession>
    <name>A0AAD2CU50_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001460">
        <property type="protein sequence ID" value="CAJ1945707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="264" mass="30127" checksum="2326ECB09368C9AC" modified="2024-05-29" version="1" fragment="single">NLKTDPVFDALDKIFRRYNKAGFQVKTIKCDRAFIPLTDDMLDDMDVTIDLTAAGDHEHTAERNNRTLKERVRKDSISSHFSPQQLIDNVNINYKSDMVAELGQYVHAIGSDSNNLMEPQSIEAIYIEPTKGQVIQRAEAWAAAEGVTSMKFFNKKRDLETFQDGNQIAGVDDTEQGYLEEAFNQDYEPEDEDERDFNLRGQFDDIDDSKRNELLADADNDVNDMPELTVRFQGDDDYESDDDDSGDEGDEEEEPIVADLDHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV27</accession>
    <name>A0AAD2CV27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001702">
        <property type="protein sequence ID" value="CAJ1946490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="472"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1072" mass="120911" checksum="310E7B0838C1229A" modified="2024-05-29" version="1">MEQQPQPQMEDCRDFPVMDHSDDMSEVTLSTIGSSKSDKKKKNPVSESRKWGLLWKTKSPLQTAKKLKKTMKKKIIRKDSRDEQSPEMMDTTIATSTIVEENSKSWGVHFLSTKSKSNKSSFFEGVLEEEDDGEVPDDEVPGRHHHHLETSEEEEITRSLQELNEKFRNQEKVDEYHLCRLELQEKNLNGRTLSAEEVYELSLLERHASGEKLYAEVNDLDDFVEKRMLYKRLQIDLADMRSQQLKGEQIDEDLLFVLELFEKRRTGQPLFTMEKLALDLLTRDRLGDTLTDAEMDELIDIMDLLRDKKNSAVTVSTTTPETNATPSGSNSSLMIEVDGAELEDSDATPGLDPWSNGASDDEVRNDVDKEHTAVTAAGGEGGWLTYWRSNHEQQDAEKTRDKIQKELLDKAILKAELLMEIDNLKTDLKKANASVLELGGEADETTKVILNEGGLPDESMPEQPSLISSESLQLVRSECEELVDLNEDKESKIASLEAQVRELRAKTVTSARKGGSKWGKKVEDQDSETISQLSAECAQLKEQLKEVNKKYEESRESHENTCARLEELQDELDQCSEDLQAARDELKIREKEIQTAAFEFSALNVRYKAASSKIERLEEEYPESIKERVEELLEEAGKTGGVDILVDCYESAVATIGALEEKLESAEEKTSNSEKLQTEYNRAVQMSKELEKDVERLQSKLKGAQSEYSKAQEEKFRVSDEIEEVRLKMEDLEVKLMSAEKEAAAANKRQAEYSESVENNKKLERDMAELQIKLEAAHLEVTTAHDEKQRVTNEIEAVIMKMKDLEAKLKGAEGEVAAANECQADFDDAVAMCKKLEKESEELQCKLKAVELEAAKATEEKNRAYEAIAEAKLQITDVGAKLRATEEENAAVANKKQADYENAIELSKLLEENAKELQSKLATAESEASDAKRERENVLVQIATMRVQMRSLEAKLESAEEEAATANEKQAEYDAAVKMCKKLEDDVGDLQSKLEAAEAKVTKATEEMKIISEQAATETKLKMAEHEKKINALAQQVQYLEGENFKLLEENVELKELCEEMIAGIGDDALDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVW9</accession>
    <name>A0AAD2CVW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000720">
        <property type="protein sequence ID" value="CAJ1938442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVW9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="161"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="676" mass="77356" checksum="176CF90FCC083F65" modified="2024-05-29" version="1">MAELFDLDPTYVTPIIPPEFEVYESRRRPSVLFVPEAPTDFDIESTPLRDKLIDSSHKSSCPEPQRSSRRKTRSEDGRWNSKDKTEQPSPPPRDPNAYESVPVVEPVYKNPSSAVKSRERDWERLRKYFAWLPKLVIQKTFDCTTQLARIPMSAHLQRHYRSPFPALNVNRRSEGVATDTVYADTPDIEHGHVAAQFYVGISSLVSDVYGVNTDAQFLQTLQDNVRKRGAPSKLVSDRAQAEVSKAVKDYLRWLCIDDWQSEPHRQNQNPAERRYQDIKRLANRILDQTGAPPSLWLLALRYASFVYNHTAVQSLGWLTPIQVLTGITPDISVLLRFAFYEKVYYRTEEPSFPSDSPESIGYMVGIAEHVGHAMTYKILNPETNKILFRSEIRSAASPNDPNKRLDPSDGEELPSPTVIKSKSDNVKSVVYSSDDESDKKDVVVENKDLIGRTFLMQPNEEGHVHRAKIVELIDKHNDKTTNNPAHLKFRVSINNDQYEDVMAYNEILERLEADEENPIVWKFKRIVSHQGPLQPDHPSYMGSTYNVAMEWENGEITPEPLSIIGADDPVACAIYARDNNLLETPGWKRFKSIAKREKKLLRMINQAKLRSFCTAPKYMYGYKIPKDYNDGLRLDKLHGNTKWADATKVEMDQLAEYKVFIDLGKGTPIPKGFQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CW65</accession>
    <name>A0AAD2CW65_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001339">
        <property type="protein sequence ID" value="CAJ1945304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CW65"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="405" mass="42543" checksum="3B0C5A5CC5412DAF" modified="2024-05-29" version="1" fragment="single">SDQMVLDEAPDKAGPTNGANSVSVEPKVEPTVNSEASNVFKNTKNDANAEQSVQKTNEQSPPQVDQELKQSTSIRTGPENDNSVVKKPSIDIINVDTVEKDTPIRTVSETDNSVKESSASQDINKDAPLQTIAEKAVETSVDSHIQNDAAPAVQPPSDTPGTAPMKKSAEETPIDNATKDTPNIQTTTVQPPADTPGATPMKKSAEETPIDNATKDTPSIQTTSAQPPSDTPGTAPMKQSAEETPIDNATKDTPNIQTATVQLPSDTPGTAPMKQSAEETPIDIATKSTPSIQAKSSGADTAVIKESQDVQVDSENKDDTPMEAAGSEGDTSLKEPQVTLADDEKKDAPMQTAAELEAPDNSVKEESASGNNTEVNNVKNVTAMPNSPPGTEHSVKEESSLQTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYI6</accession>
    <name>A0AAD2CYI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43211" checksum="4AE5A9080B16CF05" modified="2024-05-29" version="1">MFSRLLSSRNAPIASRKIIGRKWMSALSTVSLSTAHQNSHNSKTSFHNMRRRTQHENKFLHTPLSSDGFHIHQRRNFASNSRNIKDKAATPKLNLKDEVLPCHEHLDPDGNILSKSEWIHVNGTLPICSVEEVIDAFETHVLRESERWGIIDLDAPWNPVEEASVPTLSLDPWLTEDGPRIVEAAHVVISPFGRPNGWYIKFPNRSFSNALLSRAQQEHFHMSWKVVQVSEHHYDPVREQEENYAYKNGFVVDDTMVRFENCPPGMRDEDIRLRLSRYDLAPEGKTVMLWKAWTNDGKRAPLMFVVRFASAAWARAAIREMQGLRVNGKSIKMIQYPNQLVYKNVTKEEEETRGKDDPEAPSDAASDDSEGEAKEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZ99</accession>
    <name>A0AAD2CZ99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS8473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZ99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041973838" description="L domain-like protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1943503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="52856" checksum="E17AEBF36063683A" modified="2024-05-29" version="1">MVTVRLWLISLLAIHVVNGETIRRERKREKESKHESIQLRTRWFMHAAQNAKASAAGFDTEDETLMLQFEAMIEENMSIATASPSAASIAPSPTTRISSFPTTLPSEGGMTPSPTKSPSEVPSSTTAQPSESQSASPSEGVMDGTPIGVPMNSPTSIPSLRSGVPTLSPSLSLPEVPSASPSVIPTSSSTTPCNMSPQNRADSMLALINVISRQNDVIRGGSPQNLAANWIINGDEAKLCPQDDTWIQRYIMAVFYYSTNGNRWFQCQSPSDTGLSISEANEACNLTSTSAEGTYAWLTPDSECLWAGITCDDSENTIEQLAIESNGVSGTIPFEIRSLQSLVNLSLERGIITGTIPEDVGFIRGLETLDLDNNIIEGTIPLSIYRLTNLQQLDLDQNELQGTISPTIERMTNLRLLQLNSNNLSGTIPTELGKLPNLSVATFERNQMDGTMPSEVCANVDVLSTLTTDCLGAPNRPSPPFVACSCCSGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FD91</accession>
    <name>A0AAD2FD91_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000233">
        <property type="protein sequence ID" value="CAJ1933001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FD91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="207" mass="23142" checksum="AA4AAB0489D6130F" modified="2024-05-29" version="1">MTSLIQQTQIPSVRPPGLLSPQPQISWYNVKFSWQKNHGEEKLLSSNPRNPSRDALRSLHNIVSRFARIVGLDKTDIPLAVYKGSFGEKFFIHSKVIASTLRTLAKKTYNLTDRNLQQHYKCTFHSLHAGASVILQAGAAVILHAAGINAIQIKFLLCWRSNSFFLYLRNVAHLSEQQNRAINQLASATQSEVTAARAASRLIPNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDD0</accession>
    <name>A0AAD2FDD0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000100">
        <property type="protein sequence ID" value="CAJ1929872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="313" mass="36418" checksum="0F065D29D7BF2757" modified="2024-05-29" version="1">MYLFDTSNHIRRPYNTEIGIHANRLKTLFMYHDMLPGNCSNVNDENDPAQIRKRELALFRSFPLDWQGDFINLQNDLANDDNIAWKDIVSWMTQKKRTVDRKKLMQESSQRRARPGNRTGGRGLQQNRFGGGHGHVRPSYGFQPYPRTRTLQDILKGIHKVFNVEAVPTNKIKDDFNQEAPTMVAEAVDSMASAVDAPKLVAFSQDETIKAEANNSNNRDKTTMLSRTTIKKLKALLRKAAFLNGTKTMSYGGMPSAKQYQHQEHFYQAEENQQQWNNQFNFEQEEYYPEEQEAQENFSYDEDSPFLFHEDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEZ0</accession>
    <name>A0AAD2FEZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS73</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1891559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050680">
        <property type="entry name" value="YpeA/RimI_acetyltransf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420:SF47">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="112"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1891559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="328" mass="36896" checksum="FC59E5ECF0EB3854" modified="2024-05-29" version="1">MATRRRPQNTIRLICVLPLTIVGNNRGVLALAPMDSSRTRRSLSSHHAPSASFNRQQPVCNLFFRSGTAPPKSSERRQIDPAILGQLESPTLRLPFEFSLTRGEEQDDDENLIIRHMGMDDLDEVVKMCMAEFGPAADKDPQSLPDWLDKIYFEPSIRLALQAKMRENRISNENMSKDPAIMVLCRQVEKSKVVGLVEISLQPADANKNPPKFPQPLAIKNLYSKFKGVKIEGWVTNLLIDPDYRGLGYSKLLMAATEGIARSWDCSYIFLHADASVRSGKVSQTLYESMGYEVVTDSDPDYAWMPKNTFSSVRMIDGVALLCFRKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJR5</accession>
    <name>A0AAD2FJR5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001422">
        <property type="protein sequence ID" value="CAJ1945432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="134" mass="14451" checksum="3433075F261F118D" modified="2024-05-29" version="1" fragment="single">MQLKAIYFITLLAPNIQHVVSFLPQQHVPSDTTVPHHQEKRHQQQHPSVSTNLSQQAARSIPRGGSALNMSPSSMVSTIVSSMQTGPWGILALSAVTWSVVLPLTLYKKIYGIGVAYGFSVAAAGLTMLKVLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJS9</accession>
    <name>A0AAD2FJS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-mannosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000546">
        <property type="protein sequence ID" value="CAJ1936091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJS9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057491">
        <property type="entry name" value="DiatomPyrShell"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25192">
        <property type="entry name" value="DiatomPyrShell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042040457" description="Beta-mannosidase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40888" checksum="215BFC870F925DF9" modified="2024-05-29" version="1">MKPLRPSVSVILFFMLSTIKTFSSAFPSSSAGLRRTIHGTTLDSRTPPKSDGFMILTESAAKNQRSTETKLNYASSSIREVVQGSSLRVFPFSSSRTSRSLRIDMMTDGRPLEARVELWHGPDHCPQKVRVYSENGYDRPFRACIEPPSGDSNFAVAIKNTGKNFEFPLAASVQDLEAMDEADANPFYDSQLLLEDGDDSYGNVLSRTNGRVIQGGAIRSFNFAPKVDKIQVLLETSGLPLCARIEISQGPDSNKQVMDIFSEDGKQFPLYLAIDLPHSSSSSSITATTSSPVSSVDGQEHVMRIINAATMEYPIKVWTDSYTTVGSNDNAASSRIVETRRLLEASMDDNTNIPALRVPNVEESKSYRNTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKM0</accession>
    <name>A0AAD2FKM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="1">
        <location>
            <begin position="87"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="286" mass="29733" checksum="73A93C03CA7F711C" modified="2024-05-29" version="1">MPFPSLMPQRLTMEGMIENSNIVLDHAATVDRNGSMATLFQRAKGIMMISVVESAVILSGAAGTGICMVKDEATGKWSAPCSCGLAATGYGIGFGAQVKNMIIFAFDEKSVHSFTSKTGLKVNAGTQATLGTYGCGAGANLNVSASGIGADGSVANYRTGGTATICFTKGAFACAAVSGAVVGPRDHVNHGFYGKKDLTAQQILFGGTDVHELLPKDKQTAALEGLYEKLALFSKGHVHKVNPENFEETAGDVPVASINMIENVANEVVEQLDDRPPQPAAIEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKS5</accession>
    <name>A0AAD2FKS5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS9803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="1495"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1820"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1824"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1854"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1865"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1892"/>
            <end position="1931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1945658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1931" mass="219039" checksum="C3D4415E95EF3FDD" modified="2024-05-29" version="1">MSSNHDDDDGLFDENDDSSDEEVAVVRKSSKKRKGNDKSGGEKKKPKQSWIDDAAEESGDEGGDDDDEEDDDENENDYIKDDFVVGEDEVEFKKKQKTGDLEDSDDDDEDDDDDDTGGRKLSKKKRVKKKRNNLELAEEDLDLIAEARGDTERDSKRREREEAARKTVFGRDQDELQKGLFYDSGDDGAAATAAQSKQTKRRMVEQFDEDGMDDFIDDDLNDQSQIMASARSDAYDDEGAGVSEAQLNEASEIFGTDYLEFMANEDQNMDEEEELGGKYRERGVGVDLLDSDESSDEDDDDDDDLFGDDDRGGDSVQASQKREALKLKREKKELARQERRKQKLQQKNAKRKAQLRRAFEPVQLIENFCTDRDDEIRRLDAPERFFDWKSHFHGSPDGGDPTEEEEEEAMWIIGRIPEIASEYFAPTQNMEEMEEREKRVMNSIVQALRLLHVDKLEPAFIKRYREDQVASPAVRENLYRIMDEDDEYNTMVTARTKVGEILESVIRDVDHIEARGAEADFVKKLELDLMNAEEKLEEAAKQESQLKTEIEQLDSTDAVDDDDDDELFGDDDDNDNEAKKEKQETLKKHLSTIQALMEDRAEKVTDVQTKLASAQATSRESMQDQGPAQEVMRKTCRESLWNAEDIVDYLSGLTDMRHAVDLNMYLSLIKEGNDAIRKKEMPMLSQSDKTKDGRKKSRRFDRDFYRTCVSEGLRSICYKFLLPPNRVGIKIEDMSQSQNFDFNKAMPGEQNPSPQNWVAPMLESQSPDEFANDLIGSGELILLSSSGGTDPGDQETSDPLRGCRYVAAMELAHEPRVRRHLRNIYRRYAVLTTRPTKKGNEIIDAFHDYYGLHLIKDKGVKEHFPMDEKEAAEKKAMLGPDECRELDREMKKREHESCLQYLRILKAEHTGHISVHVHLPLKEQFDDWYTHEEQYATRDKQDIGALMEELERVYFPLDGDTEEWNDERRKILTQALIQFLLPRFEGEIRRELKEACMRIGVEAAGENLYNLAMEGPYRPQALMHTENRFLYPTGDLPMVGICCSADPKEPTYLASVTERGAFNDHLAIPGGTRVDSGKNREKVITFLLQSRPAAVLVGTSGGFESRILHRKMNDLISEAMQRWKDKDIQGEDEDDEDYESRRASLDKLRYEDDEDEEWTCNADLIDDNVAQLFGRSVRAKKEFPDHQTNLKIAVSIARYAKDPLGELTYAWSVASDTGNFGAELLYINIHPMQQQLPRTLLLRQYERTLCEVVAAIGVDVNAACSLDHLQGLLSFVPGFGPRKAASLKQSVEQLGETIGSRRFLLEKRLMGPIVYNNAVAFLRIRNVDVDDGHIMNPLDDTRLHPDVYTRHNWAIKIATDALERAEDETRNKERASIKALRDVMDNSAQEVERLFLATKEEWEALYGPTFKVFEWNPKVSVPSDKWRDKVEELDLDAFAGMIEESGHGKWNSHLQMIKWEFRLPYSDPRAPMEPLTGDKLFKLITGESDQSLRPGKEVTGKVMRNGDFGSRVKLEGDIPAFIPLRNLSDEHVETAEDIVSIGMVVTAVITEVKKDHMCVDMSLKMEDFKKKPSAWDRPATLPPLDDHFDWRASHSVEEKKSKEREARLEAQQLSLGHTNVGEDGAPKKRAGRIARRACAHPAFRNSRHDEVDKELKEGGAAMVGEALVRPSSKSSDSLAVHWVVQEGSIKVVEVIEEDKDNDAAIGNILKIKDETYGSIDELLGRYVAPMNDYVEELMSHRKFADMPEDELDEKLRKEKTANPKGIFYNICWMEMHPGYASLRFILSSTTRAHPIGISPNGFVWGTIKYPNLDKLLNDFKKNPRGSSTGKRTASSSGAQSQKPTEPRASRWGSRPPPPSAPPPSWGSQSAAQPAPAQQWGAASATAQGQWDRPPPPAAGYGQPPPPSYGPPPGGPPPYSRPPAPPNYPPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLN7</accession>
    <name>A0AAD2FLN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS7779</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLN7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="50"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="518"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1942102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="555" mass="61566" checksum="469E244B665BFA93" modified="2024-05-29" version="1">MADEISVAPSATPTVYVNYTDGFVQAELAEEAHEFDAISALVLNITIIICLLLAYFVKRYQIYYLPESAGALLIGIIIGGIATLSTEKLTLFKFDPELFFFFLLPPIIFEAGYSLDRQGFFENIGAITLYAMFGTMISTFVVGIMCFYAAKLGMIQSIDKENPMEALLFGALISAVDPVATLSIMGNDDLNVDPLLYSLVFGESVLNDAIAISLFRTFAKYYKPDGPDWSESEIPGALLSFLVVTTLSIVVGVGLGLVASWIYKHTDLNFFPKLETSLLFCFCYLCYATAEAVELSGIMALFFQGVTLSHYNSYNLSETAHVASEEIFSTFATITETVVFIYMGMGVFTGRFSNWDVGFSVLSLIACLIGRFLNIVPLSFVANFWRKGRNRITGQMQVVLWFAGLRGAIAFALAENMPGNHKEVYSTATLSICIFTIVVCGGFTERMLTMFGMKEDQTPSLGMSPSSGDRVLTRITYEPHTPSRRESLVDRHRRRLHHGIKGIWQRVDENFLMVHFGGDADRPRSSPEPEYEMGSIQNDSSEDSSENGEESSFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLS5</accession>
    <name>A0AAD2FLS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="267" mass="30000" checksum="6A50251D09060712" modified="2024-05-29" version="1">MRLQPLPRDELLDIAERGSATAVTVLLFWGNTAPAIIFDKTEDVPRLCRYGALTTTIVVIGCFRSSYRKLLTPDLSENERKLGFVLFWSVGSAFCEVISWLFIEWHARLFATARLLMHGVSWQALTSLGCYDSSSWYESLKMENAMACLHLSGKLFFLALACSKYNQQVRSELEFREALFWFSTLGIFQGYSLVIQSFSLSRQMDGLESSWPDPANSLDQCLVWSIFVIPILGSLVSSTFAYQLLFNKGGVQPRQQQAETRPGAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNE8</accession>
    <name>A0AAD2FNE8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="283" mass="31491" checksum="2AEDEEFE89D8A6C0" modified="2024-05-29" version="1">MAQAHASGSQTVPSTQWRRRDVQEPHCPHQRGVADDTDVMELNDDVEVTGKDLLPLVQLALDLWSGGISATGGAINPAKSFWWLIDFKWRRSSGTWVFQRKAEMPGKLTIQEPTGLWATLRRLQLDEAERTLGVMMAPLETGTAPHLPLQENAKNWAAKFCPQHLLPDDVLPLIKHDAPSLILQVSLHKTGVCHSFPRVGVFATLKYQGVFHHLSVLMRHSASTWRPTYSPTNSKRAPPFPCFNKNPPTQGFLPLKNGSNRFGSSLTLLASNPPFLVPSPLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQQ5</accession>
    <name>A0AAD2FQQ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SKP1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS12324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1949905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19134" checksum="D81FD10EE0C803BA" modified="2024-05-29" version="1">MDSEEGTVVLVSKEGDKFPVPKAVAYMSGLAKDTIDDENDDDEPEVPLPNVKADVLRKVIEYCEHYLKEKMTDIEKPLKSNKMSDVVQEWYATFVDSEEHEMLFELILAANFMDIKPLLELASAAVAAMMKGRTPEEIRKVFKIQEGDFTPEEENRVREENKWCEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQS9</accession>
    <name>A0AAD2FQS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial ribonuclease P catalytic subunit</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial ribonuclease P protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CYCCA115_LOCUS12322</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18718">
        <property type="entry name" value="PIN_PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033495">
        <property type="entry name" value="MRPP3_PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PROP1-like PPR" evidence="19">
        <location>
            <begin position="968"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="PRORP" evidence="18">
        <location>
            <begin position="1312"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="103"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="277"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1502"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="666"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="717"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="747"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="792"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAJ1949901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1532" mass="168176" checksum="8B6790D9208A7985" modified="2024-05-29" version="1">MGLSNNNLSATSTSQHTKTEESFLFSSTMNHENERSTDLCTKRKAAEIEVDAMDTSLKASNIVGTSDKIPQQREPPLKKRFSLDLLSEASAMLAQGFGPSKIQEIVQRQENESSAIREQQQQQQQEMEKNDSAPATSSDQMVLDEAPDKAGPTNGANSVSVEPKVEPTVNSEASNVFKNIRSDANAEQSVQKTNEQSPPQVDQELKPSTSIRTGPENDNSVVKKPSIDIIKVDTVEKDTPIRTVSETDNSVKESSASQDMKVDDINKDARLQTISEKAVETSKDTPNIQTATVQLPSDTPGTAPMKQSAEETPIDIATMSTPSVQTKSSGADTAVIKESQDVQVDSENKDDTPMEAAAGSEGDTSVKEPQVTLADDEKKDAPMQTAAELEAPDNSVKEESASGNNTEVNNVKNVTAMPNSPPGTEHSVKEESSLQTAKFTVVQEDTPMPSASLEADDLIKEESSSHDAEEANDVKHVAAMPTSSTETDNAVNQEVSQPVKVNGVKEDIPMQNASSEPVSSVKESSSDNAEVDDVKNVSAMSPSPKTDNSTKEEPSRPTKINGLKDDSPMQTTSPEDDTSVKESSSLDAQVKNSSDMLPSSNDGVSNGGIPAVASEAVESSATNSGEDQTGETVAQTMVANGPLVKDAKELNGQQEQSGESMAIGDTIKEMEKATDEPKTADEPKTAETKVEEAKKDTTGEPMSTDEIVKETKEESGATVSTDESVETMTQETRGPVSGTTSVLTETQQEKEESVTNGEKGPETKEENRQAEANEKLIEPAQQESGNGIGDDESAKGTKEMPDKSVEKTKEEERDPMAMDEKVKEKAEGNEQPVASIESGKEMNGESCERMACDEEAEKVEEDKSEPMIIDESAKETTAANPSTSSRETENEIAMEKPAVSDAPTMSRDDTADPSQGSSGVIESSAEAAMDVDDTKTGEQAIGNGIKLDEKETACENQSAQADKKIPKKRTNPEVLEIRKRIQFGCRDNDLSAAMAAYDEAIDKEIKVEAQSFYNLLNLCDGTERNVHIGTPKAKSTLSDGIDGVPDVDEATRLKFAFRLRDHMKELNLSLNEAAYSAIVKLLSKSREFDQALAILEESENVQQCKPRLRLYSSLLIAYCEEHRMLDALEIWKKLTQQKLQATEKEYAALMQCATSTGDAIVFARVLTDLAEDVLVPSKGTVSRILEWFEFAHSFHTASLTKRRADETKVCECLEQIHAGEKEAPPNMGPVVNVNAWQISSACPIDMKSGTLQTGCLKGCKLSPVNISQRAWDEMRDMNEKIVTDGQVEGHNTQFQGGKKGKKRMDFSPEERKQEWDRFTNFLDSIGHVDVVIDGANVGCFEKNFAGAPKHIDYRQIDWIVQHFSKMGKKVLLVLHERHFAKHMMPDNFRWLEQKWLNGRNLYKTPRGMNDDWFWLHVAYKHQSLVVTNDEMRDHHFQMLAPRTFLRWKERHHAHFDFGNWITAGDGSRQREVLLTLPEAYSRRLQRVEDGLVVPLAKQGDSNRFMDGGHAASDDEPEEETYLCIRPNKPQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR01</accession>
    <name>A0AAD2FR01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS12474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR01"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="4">
        <location>
            <begin position="341"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="451"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1950204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="556" mass="62444" checksum="9209BCB104371362" modified="2024-05-29" version="1">MVFYYSIRGGPCRNANSHIILDGNKDIICYVGRDKHENEFLIKYGWPGDIWFHVDSLSSAHVYFRIKNLHSNTRIPVDGIPIDDLPTDTIYDMMQICKNNSIAGSKLASCKMVYTPHSNLKKTFEMDSGTVTYHNTKLCRYGRCDKDRPRIKELEKQKSEDITIDFYEEFQQHERHMVTRKKHERKQGTTSSAAATAIYDPVMEDLKHLKHKSKRQGDELSGIDAALEEMGFAKSIATPNTTLDDDGHHGDGDDDDDSRSRDPLWMQEDKRRRMETSNPYLIFLCERGYPLDQAKQTLETHPKKLAALKALFFSCAEDKGMDSSSTGGDVDKEELKSARQEEKEVLQAIFGEDDPNVQFQEGDESNLDSVFPITIYEPPDRYELPPPLLMEVYASNTNYPLHGPPVLAVKGGGLSEAILNKLTHLLVKEAMTRAEEEAGDPQIFNLIQFVGEQVEALVEEESVELKKQEEERRAEQAKAAKEAAVEKAKKEGPSQTVFHNDAERRAYALGIVAAGAALAAESGNAGAGSMLPKAKKEEKHYDTGVSDKSLIEDMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR17</accession>
    <name>A0AAD2FR17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS12023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="44"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1949297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="311" mass="34788" checksum="A7F09D690F14E17E" modified="2024-05-29" version="1">MSSPQDNTMQADAANALATLQKANEAPKDNFIIPQRFTKSGRKKAIPFPLKLMKVLSNKEFENIITWMPSGRSFSIVDSKAFVADILPEHFKSAKYASFTRKLHRWGFMRHYRGEEAGAFYHNMFRKDRLDMVEQMTCHKEQLASQGASNIPKVAQVAPRPVMQQQQQQPQQQQQPMVPAQLGDEMMAKLRTQLSISGLQAPPQVGAAQRLNAAIELEVHRRIQEHIKAAAVSRQTFALVNQLQQQQQQHQVPQAPLAYGLQAHLLQQQQLAMMNKGMHKPVGLGDRSAPSEVSMGLGQLPSVNVPSARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSP9</accession>
    <name>A0AAD2FSP9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="666" mass="75381" checksum="7E96BC804BD465C9" modified="2024-05-29" version="1">MREMNRWGVDDTSPVRSTKPDHSLRSLSLTPERGRQESKDQPAPFRSEIEPHDDADCVPPQPHTIRSGVKTREVIKRHCRTRSRSLDILFSSGNDDIAPSKPKRVLSKRNVFRQEGGNKEVGHRRMRSRSLHLHMDSIFAIATCEKSRGMCEPPPSLTKSPPQDRESAETKHKASGNKKRNLHRRTRSRSLDLNLLNASNLLTTNPTCENPSDLCYPTPSWMENLSMQKFPNTRGRRNSSSNHRGKRSRSIVKRDLPPSPPDRRDSHKIPDAALPTESSNTETKLGDQRTDMCIAPSFPQRELLRRISSLTMDNSLRCQRRTGAPVVVVDTDARHVRRISSLSMDDSLRQKRTLGPVVVADTAHHVRKISSLTMDESLRQKLTVVVDAVEPNPRNAHIAESTNPQNTDATDPIPQKTVREDQDPHLEETNGHVQKFPLVVMPLEEEKRGDESFEYETSNGPLSAHQEGKENESSEFETSKASLSLHQEIQAKEKEQSALPPPPPPPTRRYTPPSPLCFMETHSRISPRLKYNRKNKTNKPKLSPFAYSIRKQYLAASQRYEESKEAPPAPTKSPRSSMDSMSHDMWLLADRTSASATQYDETFDGELSGDFSSQPHDTNKHESVKPSSLQSQVSRKSSGSDRNRFRKPPFPLQTVSTFLMGWKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU07</accession>
    <name>A0AAD2FU07_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="178" mass="19688" checksum="1FA67D91D21E5CF8" modified="2024-05-29" version="1">MSEETKTAEGDYVMMGDSNGVKMPGLDDPNLSQEDRDHRLAIALQQEENAAAYETHKRRHDQRVAANTNRTARSGTFTRLAAVRDKDQGMLTVPADYTTENAYVKNDGEYLPPGGRSDEEILRGATPQQIADYKLAKEIQKVEQAGAGTAREMSKIASEDAEEAEAQVTRTGYSNYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU78</accession>
    <name>A0AAD2FU78_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS13974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="108"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="203"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1953326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="296" mass="31557" checksum="42B2D29E4A1CBDF7" modified="2024-05-29" version="1">MSLKSQSPMATSAAPGLLTQVGMAGGAAVITVSFIHPIDVVKTRIQISSEYGKLGMGGTVSKITGEEGVLALWKGVNAAWLREASYTSLRLGLYEPVKVIFGANDAGAPFYKKFAAGSAAGAIGSVAGNPFDVLKTKLMASSGKEVPSMVGTAKELLAKQGIAGFYRGIDSNIARAMVLNGTKMACYDQAKGLVVESTGWTRNAPQTTFLSAVAAGFFMTCTVSPFDMVRTRLMNQPSDSKMYNNAVDCMIKIAKNEGPLTFWRGFMPIWSRFAPTTTLQLIIFEQLRGMMGMKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV15</accession>
    <name>A0AAD2FV15_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001856">
        <property type="protein sequence ID" value="CAJ1954076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV15"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="111" mass="12703" checksum="60A3CF21E1E6E667" modified="2024-05-29" version="1">MRYGSIQPCKIVRGKIHRYLGMTLDFSVKGKLKIRMDDYVKNMLEDFPVKFNKESKQETPAGNNLLEAGKGKLLNAEYHQIFHTTVARGLYVPKRACLDIHPTITILALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV87</accession>
    <name>A0AAD2FV87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001851">
        <property type="protein sequence ID" value="CAJ1954043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="288" mass="30442" checksum="7C504CD3C345EDCD" modified="2024-05-29" version="1">MDTLLDAHVKQYGDPEDIVKIFRQQEAIIRSLQDRIPADSAAASHIGDVRLAQDSNPQGEGDPFNVDDAPDQGNNADNGPEGNFDNEVEGDPAPDNSQEGDDVAPNNGQGSNVDNGPEGNVDNKVQEGDPAPDNSQEGDDVAPDNGQGSNVDNGPEGNVDVDNEVQEGDPAPDNSQEGDDVAPDNGQGSNVDNGPEGNVDNEVQEGDPAPDNSQEGDDDDVVVAIGRYVPCPFTTISGMPCRAFGNVSVCYLDRPRLTTHVNCPLWWPKAESTLVNAVHQSLLSILEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVJ4</accession>
    <name>A0AAD2FVJ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001864">
        <property type="protein sequence ID" value="CAJ1954267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039101">
        <property type="entry name" value="TMX2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15853">
        <property type="entry name" value="THIOREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15853:SF0">
        <property type="entry name" value="THIOREDOXIN-RELATED TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="74931" checksum="C7ED94C0629FB86B" modified="2024-05-29" version="1">MSVESVNSEIAELNAELKVCLKALNNYDKDEFFIDHPVYRYLDATDHGARREYLWKDKEQKEEDLRKEKEDLRKEKEHLRERDMHLLRERDMHLLRERELLLLKAVPPSTRPPLSPFSSRKPSEVPPSTGKDRPNATTPKDSPSSNEGKIEGLKHASDDKNTTMQCTSHPCCVELMKLLYATIEERNNKTTSSDAQDDKFAIASKIVIANKNLIGKKDADTLSSERFFTGLFANAMNAVLDEGFTTLHQACIGSGATHSDLSVCRFKSEPKWPITLLVGEGKKTAEHLRRDTRGQLFNELLRHRSIEYSLNKDPHYYGPILLLAFDKSTIDIDLAFPSKRGGQLERDTAVFFHEEIVKETETFWTVQLLRTKISSRNYAKSNLAIVLQFLSSALKRLDSWQSEGFSRVHFKLPMPLSLNDKIEHAIYYNENVSKVTLIDRRVLLFKEYCYNLRQDDLTGNQLLEPIIDQISKEDQRVPPPDELLQCLGEPYSSDWKVYTEPFGCVLQYPFIDCSSSSPNVLGWIQILCQVAKMHTAGYVHGDLLPRNVLFGKKNSGFLIDFDLSRKENKPYVRGFNFADFEDFRHPDAKPCKQMKKIHDVHSLCQISHYFFDLGEKPIQEGITLKGLIAHFKANEKLPVNAIEESKDSSGSPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXG5</accession>
    <name>A0AAD2FXG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS15846</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the plant globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001032">
        <property type="entry name" value="Leghaemoglobin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22924">
        <property type="entry name" value="LEGHEMOGLOBIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22924:SF98">
        <property type="entry name" value="NON-SYMBIOTIC HEMOGLOBIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="11">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="231"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1955631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="501" mass="56036" checksum="829EAFCE2CF5FD26" modified="2024-05-29" version="1">MEVYCASIEKAVESWKLIQSDPNYYVTFGEALFRRIFEIAPAAVSLFHFAPEGKRSETVQGFESSPKFHPHAKAVLLMLEQALMLMLESQLYDLAEALSSLGLRHLVYGVGKEHFKVLETAVLDTLELFLPHPEWTKCLQKDWQGVLHFICKGMIVGADQGFSIKRKKRELGELSVATLRLQPTPSNSNDTSAPIIMSPPPACGSRFDLHVIKSPKDPPKPAMRSRFENFFEDSLPQTPKRSSMPKRNNSDPVLKTMIPSATLRLGRGTNSPAPTVTPSPSSSTTQRNNQRRRRHTSTDLLGEMSAVQQRIDRLSFPSDRSLLDKSSSSTTSNPTSLLSLRNELCDDIGLGPTAGRPIRKHRMSRSHPKRPLSVQKHIDTALRILNEQEQQEEPMTPNNNNNNNKTNDNSTSMTFEQLDASTSTWPILGLEQDPPSTLNTSWPMLGLEQDATPVLPRRQVSPKPIKKKKKKTITARPTFVIIDPSISVDDTESPIFEPLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXK9</accession>
    <name>A0AAD2FXK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXK9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="151" mass="17306" checksum="7E8036F2152E7FDF" modified="2024-05-29" version="1">MFQSESAPTRITDNVMRHQGRASSRYDIHRRYPVLHGSSETEKDSPRTVVGKTENIPIANKDQASPAELAKIKEAQNRDTRFYNRINGGMKTTDVSQSCHQNDFLLQQQNGHVKNNRHRDFGMQNDCFIGYEDGPSIDYDTDDEAIFELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYF3</accession>
    <name>A0AAD2FYF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001923">
        <property type="protein sequence ID" value="CAJ1956673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="290" mass="32599" checksum="DF464FE4E9FB0C4D" modified="2024-05-29" version="1">MNCFTFHPSDYKAGPNSQFAPLQMIFEAKQDGRRKGRLVCGGHLVDPRGISTKTTVVKGVSVRLLDMIAHRDGLTILHGDVGNAFITAKCLEDIHSTAGPEFEEHEGAVVTINKALYGLRSSSRAYREKFAAFMRTIGFEPTRYDRDVWMRLFEDKSGYDCRCTHVDNFKVIAKDHQQWVNAIAGAFQLKCSGAPDYYLVMDYCFDVANMDWLTGSKTYVEECICRIQALVPNKSHLCVHYTPAPSEGPADCRKVLFLQALFEHGHKKEDPIDIPICNCKAPTSLMFCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYV5</accession>
    <name>A0AAD2FYV5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001935">
        <property type="protein sequence ID" value="CAJ1957059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYV5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="752" mass="84544" checksum="2C339946BA69FCAC" modified="2024-05-29" version="1">MPETQQHLLLEQALIAVPYLDEIQRLSRILETQTGMAIIFDDYVTLVESAAQSYDTRQVSKPNPKNNPSRDVCFTGVASGLDDDNLNIEFNIDTDIGEYQAYRSSFTPGHRPSLPQAQWSQLDDEADCHWQQPKAVILGASSDPAQPPPPPPPPLPPRCLVNLHDISAAALLDHFQDASMGSASGALPPEVVDNARDSILAHVTERQSLKPGGANGEIAGDDVIILSQTNRSVEVRAIDDHQLTDVSIKTLPHIVLTSDKNWDPGVLDSRVDEFDTRHDDGLEDLDPKVDDFDKWTDCITGDGLEGAKSRFDQVDILKRNKTKTTSKDSIFDEAIHFFETFQYASPFDEPYKDSERTDTGTDCPDTGPDYFDRNMVESSCPDPYYIDPPIFVMLEVNKSCRHPSLLLVTDASIKFDVEVGPLFTNESSQELTHDLPTRPPKPKDTFTIDVPSKPQCNTSRKVRFGHGNRPGNGEQPGTGPPRRNKQEHKTLPLADTMVYKNPSSAVKSCERNWEQLRRYFLWLPKHSFHCTTTYLARSPTNDHHEHKYHPLSPLPEPISCMVVLVGIAKHDCHNMTNIFLFLETNNVLLPSDICSALPPTGLHKRLVLPDGEELALPTITNSIDLSDGEELTPPTKIKSRDHKSLKTIVHSSDDESDIEDVLLEEKDLIGRTFLLSPDDEGYVQRAKIVELNYKHNRNTDIQPARIQLCLNIDKGEYEHVMAYHEIHKWSETDKDNPIDTKLKQVVCHHHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYX2</accession>
    <name>A0AAD2FYX2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYX2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="162" mass="17723" checksum="4748D0C9C4A9F2E6" modified="2024-05-29" version="1">MMTASVPSLKQQEVPSLVLLGAAESPSNSLVSTLSFKSREDIAPRVPKRKPSKDLDKVSSSKQQGDNFVANTRFDDGCISQDLGSSTRMASVVMDSLSCLSHIAKKECRMTSTSTSVHLMDDLTTKSDTSPTIPRREPSSESSGAIRECNDAFRMYNRIMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZZ3</accession>
    <name>A0AAD2FZZ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS17326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZZ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041911096" description="NADP-dependent oxidoreductase domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="96"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1958738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="449" mass="50094" checksum="BD74080B82EE87DB" modified="2024-05-29" version="1">MMKFVILCFSLSNTLVEGSTNLFDGYKKRSGLIADVPAAILSNEVEFPLVGLGVGNLQSDRVENMIYEGLKGENRIRLFDTSQVAGVDNEIIQGIKSGTKRFKEADGIDDRVQVHLVTKIRHTYLGYERTKFAVKSILQTYSPVLKDSNIDFRIHFLIHHPRCIDSVDGMDCEKDEDELPGKVKRVGSAPHLGDGDAWKESWRALEDLYSSDDYPAISSIGVSNFSVEEMDELLGLSRVKPHLVQMNISSLIEDTTLVDRCKMHDTHIVVFNVMEHIVMRAAGTPRAFKSVALTGDALSNGRNAANPGQIILKWLTQNGISIIPRTHDLDHLSENSVGALARLSDISSNANIVLQKAVEAIHMGVDLDEDPRVQMSFYASDGDIFLYRYKENLADQTYVAYVGKGNSAKIWVNPNDTFRVYNAYDPKLFKDYVLLEHDGDDRHIAVGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3Y0</accession>
    <name>A0AAD2G3Y0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3Y0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1961473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="241" mass="27145" checksum="E450DE0295D1C6CA" modified="2024-05-29" version="1">MSLKTIVANLPFAHLSLTTISIGVGIYGLPPPPWSSDNDNNRHESLLSTKQESFDAKHYDLLTELVTQMYAGRGSHHPHCHFADTAKFQDAAVICKSPKEIHEAFRLHEKLQPKCLRPPICVDVEPKGSSILVTYALNQHYGSLNLDMRSLVQVEVQLRSLVRAEVPLEEQEEEEKEPQLVVATSTPSNISYLVPESDFLVLDVQELWNGNALLGTPLFWIVRRINGILSWHVSSRVFKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4B4</accession>
    <name>A0AAD2G4B4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4B4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="358"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="450" mass="51301" checksum="018B7C818B901DE9" modified="2024-05-29" version="1">MNNNSWLQRLLGGTSATPISPLSADNNNNDLGATRQQLDSFLANSITQLDVRQRESILEDLHGIRNSENPENNPASVDLWLQLLDMHLQNIKRGTVYETAEAIDRVYVTSRKFRMMFLRANRYDSQAAAIQIIKFLELKRSLFGQEKLAKKITLADLDEDDKAKLQSGTLQISSKQDRAGRGVFLMFPSLRSNGTEYQLQTSLRARYYMVMNMLESEENQRNGIVMVYFGALSQPTQRESNSGLLWDLPFRLVGVHCCFNSLAAYLFISVAILRLPFAIRPRMRVHYGSCADCLYKLASFGIPKEAVLNESDEPNMIAHMQWYRRRQELELTYVSDSDTDMQLLASRAGGAIVPRPMDVLFGPGSRKNEGNVLMRNLALKVLAEYNDSTNRDKMQLTETIIDDITKKGGRFLKQNDDTKEWEEASHIEACRKIAHTFRNIRRPSRAKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4M9</accession>
    <name>A0AAD2G4M9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS19834</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4M9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="109"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="212"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1962743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="300" mass="32375" checksum="39EB6DF62DC0C5C0" modified="2024-05-29" version="1">MPSDFVINFLAGGVSGAVAKTTTAPIERVKLLIQTQDANPKIISGEVARYTGIVDCFTRVAKEQGVKAFWRGNFTNIVRYFPTQAFNFAFKDGIKAMFPKADKNTEFLKFFMINVASGGLAGAGSLMIVYPLDYARTRLASDVGGGKAQFDGLFDCIKKTVASSGIAGLYNGVGVSVFGIIPYRGTYFGLFDTLSGYNPYQKDESNVLRASSKFACAQSSAIAAGYVSYPFDTIRRRLQMQSEVPKEKWVYKGTVDCFKKIVADEGAAALFKGAGANALRTVGAALVLVLYSEITAAFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G636</accession>
    <name>A0AAD2G636_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Amine oxidase</fullName>
            <ecNumber evidence="12">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS20424</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 a plastoquinone + 15-cis-phytoene = 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol</text>
            <dbReference type="Rhea" id="RHEA:30287"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:48717"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
            <dbReference type="EC" id="1.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; lycopene biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chromoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="12"/>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G636"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000091">
        <property type="entry name" value="15-cis-phytoene desaturase, chloroplastic/chromoplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014102">
        <property type="entry name" value="Phytoene_desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02731">
        <property type="entry name" value="phytoene_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF45">
        <property type="entry name" value="15-CIS-PHYTOENE DESATURASE, CHLOROPLASTIC_CHROMOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0957">Chromoplast</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042206845" description="Amine oxidase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="14">
        <location>
            <begin position="84"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1964004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="606" mass="67401" checksum="243D8F3A5AC90062" modified="2024-05-29" version="1">MKLEFFSTLALLSLQAAWGFVPNTQVRTNLKSESTSLKMVDYPKPNVENTENYRNMEALSSSFGTQLKAKESEKKKVAIIGGGLSGLACAKYLVDAGHEPTVYEARDVLGGKVSAWQDEDGDWIETGLHIFFGAYPNMMNLFAELGIHDRLQWKIHQMIFAMQELPGEFTTFDFIPGIPAPFNFGLAILMNQKMLTLGEKIQTAPPLIPMLIEGQPFIDAQDELSVTDFMRKYGMPERINEEVFIAMAKALDFIDPDKLSMTVVLTAMNRFLNEDNGLQMAFLDGNQPDRLCAPMKDHIEAKGGKVVMNSPIKEIVTNDDGSVSHLLLRSGEKVEADEYVSAMPVDIMKRMTPKKWQNMPYFRQFDELEGIPVINLHMWFDRKLKAVDHLCFSRSPLLSVYADMSVTCKEYYDPEKSMLELVFAPCSPLAGGNVNWIGKTDEEIIDATMGELARLFPTEIAADETWPATMKQKEGKAKLIKYAVVKVPRSVYAAIPGRNKYRPSQRAPIPNFTMAGDWTSQKYLGSMEGAVFGGKLAAEVVSKKAKGMQLPMEKVIQQNIVDSAASYEAKEPIGIMGDGAIAFGAGASLKQENESLLRTADPVQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6K7</accession>
    <name>A0AAD2G6K7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6K7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="958" mass="102794" checksum="A4944DE2BD4C8276" modified="2024-05-29" version="1">MSKEEKKGMSKEEKKGDTSPEASMEATETKTTHRKSGRSRRSPTRSDDGSDVKSKELHGSPSSDTKERSGERSGRSPKPRHSGRRRSTHDNKEKDSSRKSGHGRRRSSAARGSRSSSSDRHGGLSGSEELSPTRRSVGDEDRSTSLSPRRDTNNKSDDRDSKRRSRRSTRATAPGVENVLETTPTREARKSARAGAMDSSPRRTNPNDSGDRDSKRRSRRSTRAATPGVESVNDVSTRESRKIARRSTAAARSSSTSCPASSTPPPATPPLDDAANNSQLDENLETIRQQEERNRNGATVAEAKKDPERKRRRRLLWILLCCLLLLLIGGGVAAFIVLRTEDIQSASTTTTDQPEDVVPTGAPTNDYLFDPPSKEDCTNLRLRRPVGDREGTIEKSFDLHFDATLTEANDVDVWNLEFLTAIEEYLLPSLLGCEDAAARRSMIRGGPNNHRRKLSTLRYIIGDAVVTGRVDMERPCLPENESELCSRSIVTLQLFLKGDVSVDDLIRLIVGLIENDTFRGVSVATSDRMLQQESQADVYIPLVTRWALPDTFESVFYILIEELTSGSSPNSAPTLSSPVPSEEPSSNPSSFVGVGGGSPVTPTTKSPTTTGGTTMAPSASPAPRPTKRPTLAPAPGVTQEPTLEPSLKPTTVPSMEPSQNPTPTPLPSLAPAPGVTPPPSPPPTTEPTAPPTKQTTLSPTPVSAPGDTPSPSKEPTPGTPSPTLASASPTLAPTDAPSSTPSLAATPDPTAAPTSEPTPTPTSQPTSTPTSEPTSGPTLAPTGAVATPRPTPAESANPTPGREVRILNFDDLETQAGDCLVSTNEITDGYQGFQWDYFAVSDITCVTGGGDHSAPNGVGPLSDPDNGNGERMSFQLEDGTFDLISVEAYNGDPGCPFFLFGYEQDAISPIHDLDVIPESAEWFTIDLSSFTGVNKFEFISTCTGVLHIIFDDFRMHMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G719</accession>
    <name>A0AAD2G719_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G719"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="191" mass="21381" checksum="D839A14BB93F4CA5" modified="2024-05-29" version="1">MPNKQAYQKHIHKVFEINSNNNSNNHKMSAPGPDFARQQELAGKKHADLKDDEKMYLMRREIDHLRSVIRDQNDGSLQSAAKPRASTSTSTSSIESSTSSSTTTSTASNAMDRATVLTLFLFVGLVVVAIWKRRTHRRRSVQHRTNARLQEEVMTFELQNSLAGGYRYEAPTTTSVTNTTVAQGNADTIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7B2</accession>
    <name>A0AAD2G7B2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7B2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042097682" evidence="2">
        <location>
            <begin position="34"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="373" mass="36707" checksum="56EA85C0B0C63299" modified="2024-05-29" version="1">MSTNANIKPYSVFSRTLTLLALIASHQFHSILAGVITYEANCDTLLDSDTNQCCGPSTASNVCFDIGGGAGAGTASVAKGSCKNDDACRDAGNDGQISIGGGSCIGSESCNRAGNVNGQATIGGGSCIGIDSCTDAGNNDGQATIGAGSCTASNGCSAIGSNFGNAVIGSGSCTKSLACLNAGSRSGAVTIGDNSCTGDRSCQDVGIRGDTVTIGFNSCTCDDCCRCLQNGDNIPDNSCNGLVEECCFGPGGNTRRDSFISGLSNAPSVAPSGDPSTSPSITPDSGGGGGGGGGGGGGNKPRGPWGSDPNKMKSPPAPVTPASVPSESPSSTPTVPATSDTPPLVNTNRQSKKSQSRADLLRGTKLSAKKSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7B9</accession>
    <name>A0AAD2G7B9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7B9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="500" mass="57230" checksum="AE7BDB154BAD168F" modified="2024-05-29" version="1">MARTRRQARRRWRPQRYASSDDEAQDSFRAEEEVQENDSDLGERGDADEDQDPQDDPDDGDDPDENEDPDDSGDDDSNEEDTDDEKEETDGEAPGSLTPGLASMGRILRYEKKSDKSIFNKATSKLDDEGFDCTSDQFLQIMKALEHRGNNFGWNDTGGLFWVLTPGRQPVNLLHSYGSVSLPRIQRYERTYWDSGNRKSQDDRMLYECIMNSLTRDAKSKLNIHWEDFQLGPNKLPSGLCLLKTFIREAYLDSNATTGMIREQLSTLDAFIPTVDHDINRFNNHVKMLLMALHARGEKTLDLLTYLFRAYNACKDENFVKYIGDLQTDHDMGTKAIDSRTLMSLAEKKYRIMVTTKTWEAPSAAQEEILAMQTRLNKLSDKLAAKTKDGKQRKRKELGADNGSPKKKVKFEKGKGKKQMKEKPDWMSKPPPKTELNRPRSWNNKQWHYCCKETGGNCGGVWRVHLPKNCKSKPKHDDEKEPAIVAKEAIDDLVGGYYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8E7</accession>
    <name>A0AAD2G8E7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS20200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8E7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="585"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="814"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1963514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1198" mass="133253" checksum="667315CF622C257C" modified="2024-05-29" version="1">MSFTSNHGKPLNGASVATNSVSGGGMTSSSSGAESKTMSEVQETTHMLQRDHKVRRIRIMAISVLFIAAASVCGGVYTSLKRSERREFENRFADQASQIGHALEAELDNKLRAIDALSVTITSFARSRMGQWPNVTVPEFPYRAASTLSVGRAISVALQPTVSMNQVSQWEAYSNQHQQWQKEVLEFQAKYPEAIRPESVVDDGPNTGFNRNAFKPEAASTISADSISDFVYRIDSNGFPTRVISDAKQGIALPLWQHAPVHADGLLPRTNFDTYSVEKNAGALDQVIQNHMAVLGKTFELSDSSQGHDFPEMDATLETQSWNDVWTENGPSTSAIRTRQSPSSNVKQNQGSNGVSSSSLSNGLDGPAVNIFYPVFSDLNDNRTVVAVLALTTKWDSFLLPNLPPDPNGLIVTLRNECDQSFSFEITGEEVIYLGTGDYHEEAYDKYGKDFMLVADSSVFTEVPMASSYCSHTATVYPSSQMREQFATDAPTFYTVGAAIIFLFTMFVFVFYDYLVQRRQNHLADKASKTNAIISSLFPKIVRDRLLEGEGGNNTSGMAGIMKVNGDTVGKPAGPPIANFFANTTVMFGDIAGFTAWSSSRQPSEVFTLLETLYGKIDSIAREMHVFKVETIGDCYVAVTGLPNPQEDHHLRMVKFAKRVLKCMGPLTREMEVMLGPDTTKLGFRIGLHSGPVTAGVLRGEKSRFQLFGDTVNMASRMESTGKRNYIQVSNSTASLLAVSGKEHWITKREDTVQAKGKGSVQTYWVKKMVTHAEKTDANSIGDSSHSEKKSSSKTFVSVDGDLHGENENRIRKTLIEWQVELLSRLLKRIVAKRSYHSNEVQHSFDVFASEKTMPREEIADEVTMPSFNSRASLRIATSQYTQLPSEVLDQLEDFVTSVAFLYRDNSFHNYEHACHVTMSANKFLTRVVDPKVNGLDDSSPQAPSYEYAYGLTGDPLTQFAIIFSALIHDIDHQGVSNKQLTDENNRIAVMYNGKSPAEQNSIDLAFEVLGSSQYHDLVSCICANEEELKRFRQLVVNCVMATDIFDKDLLAIRNKKWKKAFNSEVEGGSSSDLKATIVIEHIIQAADVAHTMQHWHVYQKWNEKLFFEMCTAHETGRGPAKDPASGWYEGELWFFDNYVIPLAKKLEECGVFGVSSDECLNYALENRKEWETRGRDLVTSMKERYVEKKEEKSSGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8H6</accession>
    <name>A0AAD2G8H6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8H6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="394"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="574" mass="63111" checksum="101BD77C66EBCBE2" modified="2024-05-29" version="1">MHSYHSIISNNSDFVLDFDNDEEKDTPVLLSLVESDDETAELSSGEEAAAEEVCDMEFLHRLIADAGRWAFGIIFAELWVLDDTGTQLFRPDCGWWMDHYACATHAFSKLVDSSLPDYIPAEPCMPGIGLPGYLWAQATNKAGNTRQSVMSGRQSLFRKSSVGIRTSLLGAGGGGKMSSAATRSSMYGTISNLHSSNGQHQQNHEQCCGHQPHSKMSWCELKPLVNDPNQPYDERTQYLVNKAGLGLAAGVTFDVGGTRGIMIYMARDTVSLKDLADSTNEEYLQRATSVIGSAYSLRRARIAVVKKRRKDINKCWRRVRIKLLAIRCMGLSLAKVVEREEQKAALQKGKPQSMKDVMKELDGTVDKVAGYFKAKIKQETKKFMGANVKAPPPMGWSASAFTFMGCFLTFGMLTNFSNVMVKSFGPEYFIALPPFGALMGLHYGLTSAPASQPRNAIVGQVLGLTIAHLIGTHLKAELWMRQSLAIACAVGIMVKCSAIHPPAGAAAVAFSTGNFTWVQVGMMLVGNVLAILSSTLINNWNDQRQFPTFWGFRPINDYFSALFSAKKESMDKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBK9</accession>
    <name>A0AAD2GBK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002402">
        <property type="protein sequence ID" value="CAJ1968714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1389"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1588"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1626"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1659"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1734"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1791"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1852"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1885"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1918"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1933"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1986"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2014"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2044"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2072"/>
            <end position="2083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2087"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2125"/>
            <end position="2142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2142" mass="234709" checksum="94048D58C41722E9" modified="2024-05-29" version="1">MMASDDPQQGWKRLLSNFSKTDIVDLESAKSLQSLHRKAYSKVYRNQMNQRTFFLISVVAWMESCNWFEDDPATGRVYVDLASVIEDISNTDSMVSWMIPSVTHVPNLGRAFDPKQAWISFWMGYYDQCNEAVEEGPPKAKKIRMASSSPRTSKTQESKHGLPCTLLMIALLYKQEVSSSTSTNINWDQFHESVFRSLSPRFKYTKEYTNSGLFLFGLHCILSNIKIDDLNPLGLFQKYLVSLGFSPLSDAILQVYLEQHDGLNKYALRASICEDLLETIYESDDMDDAAEVKLIHACSTFLSQESATRYLADLSSPKAAAAAADVAESRKRDRSSEIPSRIGSPGYPVIVQAELYLQQQREEDAIELVSLLESNTNLDPVTVDQGWLTIFQHFFNQGDMFLERNFVSSPEYCRKRDLLFFAAEKMGPLGRHSMFSFYLDLHNEMVASPVATPDEVHYVEIACQQTLLRLVYKACGLRSSTIEYFFSETGRQWPSLVPPGDGDWKLMNLEQWVADFLIRIPEIPESLKMQDASFGGKVDLRRFMTLLQNTDRPAEEPILIEPEEAPTRDLQDSTTANDMAQNALPPLAAPAETKEPEPFQDVGPSPSAAAGISGLLFAAQAPVHSDEEQEDETLGYGQSTMGEAAAQQEDSYGKLGVNMYAPTNVAQDYDDDDESEEEIIQADEYADEDNQEEKGGDSDVIVLDDTSEEEEEEIAPDSDQDVEEEEEDVDDVASAGDVYDDESEAEVLAPPFVPLQHEEGSRGDDDDQPVGSEEEDDDEGDDHDDDNGAAAAMEASNSPSMSFDDGGEDDVEVIGSSPEKASANLSADDKRADSDDVEAVDSSPDKALAAANLSAEDKGADSDETEDIDNDEDDDDEKGRSVSKADLGDTTEDEGDEKGTGAANKAAAASRREDAMAVATEYASQIEEGYEPEDTHGYTEEEVSEAMHTEDEEEDRRKKEEANRVTIQEEPEVIVPVKPVDHKVGNSSDDMDADDEHTEQEEDLGAESSELEEHGDGPTPVKKYSPEPPRARGDTTTLWQYAQTAQRQHEETLMQDGKGKSVGFEEGTKKGDDDDSKKRSKSDDSDDEGGEAGTESNTVYTTETAEAEPAKDSEDDMSEEMTAPEDTEEKHSKSTGAMDASFGARGVQADDEADTADDSPEVPRDDAHVESPKDDVAMDDDNKGEEKTGGAEGETPAKEEKAIAEELTAASSDAQEEAAFLDKSINDVAIVTEAVGASESKTSDNVQGPLNDDDELSGEAETEAPNKAAVADETTETGTAEIPESPEEDLVSTSNDEVEALAKDEMLAAPIIDTAEDDIASTAIDEAEASAEAEISPAAETNEESDEKNAELASDKIEEDTANPESTPTKDPTEGYNNGSKEDKEASVINESSDNKTCNVADDATGDDIKADVSNVASVASNDEEIDGDEGPLEDEQSDEPVPLEAEIAEDAADQMVIVKSNETEMDMMDVAEGDQHQVAMAESNVQDDEPQEDKMVEDEDDVQMGDAAAPGDEMQVDDEARSTDDIDMQSYVADDADMAEDIQDLEKMEDAPMIDTANLTDEAMNEQSMEDANIVASAPAPAVPKEDEGEQDQEEQENENEVGQEQEEDDAEEEEKEVAYAGKSDEEEDEREEDEPVAQPPAKATRQSSRLIASKEEAESEEEAESEEDEPVSQPPARATRRSSRSVASKEEAESDEDEPAAKPPVRATRRSSRSVASKEEAESEEEGPAAKPPAGATRRSSRSVASTESVESATPTRSTRSRGKETDDADDSDEGSVQSTSSRRKTTRATRAVTKNSPARSTRSTRSKTSVSTRSTRKSSRAKLEPPVIDENAEADQDGRPEVILTTVMDDQERDTKLDDDEEENTKADEDEQSVMTEASHSSSKRSRSTRSTRGKKAAEEVEEEDDDDAGSKNTRSSRRSTRSRKVKDPVEEEEDAESDKEEVKEEEPEPKRRATRRSSRSAKKEDSDDEEDDDQSIASTISRTRRSTRGSKKKQLPDIPEDESIASTVSRTRRSTRGSKKAAAESTDDDEAQSVASTASRTRRSTRGAKKKADDSEDETQSVTSTASRTRRSTRGRKKKAAEQDDDEDDDDDQSLASTASRSTRRSGRSSKKGDEVSSPAKRTRSTRAAPARKTRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBR6</accession>
    <name>A0AAD2GBR6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="438" mass="48400" checksum="9DA3B9F2A17631A7" modified="2024-05-29" version="1">MERKRRKSNLTTEGTSVENRTADPSDSPTSSTDGADDPANVPLAQSFPSSGESSEEEELARPNPARPTEKVISRQGLGLFLRGFETIESKARKKRRFGSVEEPAEPAHVRRQKREYYDSDNSYEALDASEYSKVNVETVDYYDVAAGPSCDESIFINFDRDEVSELIGYATDAKREASISAAAKYASLPALMHDKSRAAAPSLAGQSLVSSLTSVTTQSHGVDNPLLGLPSTPLPTSHLRYISKMAAQAPEFSVKLENRFSDSALVATGMLVEEMITASLMPLAGYHVMRCRELEVRREPRATEDSGKAAKIDQKPLVHPVTGRVMQSDKILVNPLEKSSEEWTLPPDEAMMKLLEQDAIPPEGLYLTPPATQTLHDENRKALDKDWEAVQLFSTDNKITPENAIENMDIYRLFLQMANYKRPTEEFSDGSSSDEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCD1</accession>
    <name>A0AAD2GCD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitinyl hydrolase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF95">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="7">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="274"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="658"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="798"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1136"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="670"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1175" mass="132250" checksum="005DB37566E20DB9" modified="2024-05-29" version="1">MVEFAVSDNRADGLAITEAFRQASDDDVRNAMNAMSNPTDVDSLKFYIIPSSWFVKAWRLFGARSEDDVDENWRESIGSIQNIELLNIEHEVTSDEEDPAEDQQKKMFEKLHLRMAKNLQEGKIMSELEHTKDYFFLGASAWLLVKEKFGFDGLELERPCVTNAANGSLEIQLKLEESNGTTPKLITIPPSGRFAYEKVMSSKVSNTVAIISEGTNGNASRMPNVTTSNPGAIIPFNSTSKSKNGKSANEPEDSNDQDMETDSQPMAGRKRHASGLGNIGNTCFMNSTLQCLAHTEPLLHYFLSGEYQADLNKDNPLGTGGELASEFANLVREMWGIPIRRHGVVTSSSLSAVYPRQFKQCVGRHAEQFMGYDQHDSQEFATYLLDALHEDTNRVTKKPYIEKPEKVKDESDDDAANKAWELHLKREDSRVLENFMGQVKSRLECCTANCDRVSTTFDPFMYLSVPIPGETDRQLKITFVPLEPNEKPRNFELTVPKTAAMGKVFSMLNDELIALGVRSDPIPLHDFVAVDVWSHEIFSWYQLDSDLDRIRETDTTFIFELDPQNEISIESKKRSDAPDDVEKSLSKVSDRSRVNLDVETLTSLNKNDHWQSEIEKYVKVSHTVYILFNEKRGTVEDRLHFYNKLKIFLEQCQKEVEDHEESSAKTDAVKDDDEMKDEGGNDGDGDGKTAADAGEIQGLIDRTDASPTFTNVKTQRDVEILGFCANKIRQLILKLITDKKNLYSDGITIQISMRKHKTAYSSSTKLATPIALRIPSTMTVYGLRKELAKRLSRSLQSDLKDRANNSAGSADTLEDKSRPMNGDHVFGSPELSIMRQVPLSFDRKDGTSYGGTRTTYNSKQLGMLEKTHDGEGTMADPNDDAEMAYVADILGPLGNVTLEWPGDLCDRCFDEVEYENVEESTTEEDGKKEEKAVTNVLDCIEKYCQMEQLEETEMWYCNQCQQHVRAWKQFHLYRAPPILIIHLKRFHYSARTHRRDKITSFIDFPLRGLDLTKLVSSYTEEGKPIYDCYGVSNHYGGLGGGHYTAHILDEDGSWNYYDDTRMTKAEEKEVLSEAAYVLYYRRQDVPFERNVAFPTPEAIPPLPPAPAAIEGEPTNAMGNDESDLSSNVSTFGVVADDEDDMAVDGDSKADSSPVESMDAEIDIAGFTNEDFPPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCM4</accession>
    <name>A0AAD2GCM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="212" mass="23405" checksum="AD73B3978F19EDE6" modified="2024-05-29" version="1">MRSTRTIMERNNQTIAFFNDSDYLNAIEASALALSSLREASAVDPTESSPDEEGSRTSNTDGSSHSNAPSGSDRLDQCMLLPAAVQNDFKTLLHSTNFIYDNAIQIPPSLEVDTHILGAIVIFNAALAHHLASESQETPTPPEALHKAQRLYRLSYQLYGGGKSLLFQFAVLNNLGVVERRLGNTSISNQYFDYLASLVEQFENKQQHQEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GEN0</accession>
    <name>A0AAD2GEN0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS24492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002524">
        <property type="protein sequence ID" value="CAJ1970476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GEN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="279"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1970476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="356" mass="38481" checksum="92E202E355AD852E" modified="2024-05-29" version="1">MEETMARLEHLGINNHDVNDVNDVNDVNDVNAKDDRDYTALHKACSNGQLELVKLLIAKGADLHAKGYDGSTPLHHGCRNGHLEVVKVLLEKGAGGEDHTNDNTQNNTTTPLHTACDEGHLEIVKWLVEKQGTATVNSKNEMGETPLIMASLEGHWDIVKFLLENGANAVNDTASYGMPPLYLACRGGNVEIAKLLLENGANVNHKDKGGGFGGGTPLDFACQQGHLAVAQLLVEKGAEINTTDDCESTPLHAACSEGHLELVMLLVTKGADLHAKNDTGRTPLHQACEKAALHRRNYNEIKEDHLEMIKLLVDNGADVHAKDENGNEPADLFKSDDGSDEDLGPQILQSLLKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GEZ8</accession>
    <name>A0AAD2GEZ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002480">
        <property type="protein sequence ID" value="CAJ1970202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GEZ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="591" mass="63461" checksum="32DB3ED23E671184" modified="2024-05-29" version="1">MKSNNEKQHDGDSEGTPLLQQQNQPPQQDTTVPNYNYNYNYNNAYPQPIPGQVPVAPQMPVTMPMNPSMNPNMNLNGNDPNSMAVFATLAAQYEQAGYNPSDAAAAAASMTAYQQQQQQIYGATSAFGYPTHAQAPMYYSSQAQQTQQAQQTQQTHQYQGMAAPSTNPLPPGPPVPSPLSPQAAATSSRPPRSSRRASSPILTETNGNGNGNNSSSLPPLQDIFSNNNSGNNGNNDSVTSFNSASNNNSNNSNYGSIAQNNSPIWSAPPLSTPPNTSASGGAKRVKPVLIRTSSSGAIARLQNSPNPAGRRKHRRSSSDMPANSHRRNGSVESPLLLPPSGSGHRRAGSFGGATGSGSSVISGGNRQRAMSSGSNSRPRRGSGHRRTASSGSVGTFASQVSTTSVRSNIVKSSMFGGFDAHTGQVQMHFPFEAVRLVFVDDEEDPNFAKQNKRAKQPPPPVDPHSMLTQGHLYMEGRASDYDDFEDYTDITNAIEEGLTPQWETLDRVPTNENNNLDMNSILKPPNYVLPVSAKVYKRLVGEISDAHYMPCGLFFCGHHEDVAHPSITIALVIVILLFGFMAYVAFFIEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGJ0</accession>
    <name>A0AAD2JGJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001742">
        <property type="protein sequence ID" value="CAJ1948121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="143" mass="15341" checksum="49D7DFFCB86CE40A" modified="2024-05-29" version="1">MQEWVNNPRFFTATYSGSSRGLLLCWHVFVPKAFARKANLILAANLDILPTAPVSDRSHAGKDSGDPSSDCHLGMLNSAATENFGKLTLLRFLLAVIVTGAQAKKAEEAEPQKPPAKALEVLSDSELSGDKDVDAGLLGYDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH18</accession>
    <name>A0AAD2JH18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TspO/MBR-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS12215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH18"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041969330" description="TspO/MBR-related protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1949673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="33903" checksum="27A4316FC45BC202" modified="2024-05-29" version="1">MRNFHLLYSFALLITCSRGFTTAWAPATTTRRTTTTNSIHQQPFGNQIQSTSASKSALFFAPQRSNRHRPSIVIDIASSKISVIDKSSSSTRTQTTKLDAAPTSIANSLPFANSPKALIAISIIGHVLGGLIGTPFVIRATRGPVSWYRKISLPSWTPPDAIFGPVWSTLYALMGLAIGRLWNATASNPQPMNILALGLWTVHYIINVLWAPTFFGMKKLRLASIMNGLLLSTLIPVIVLLGFHIQPVPQPATAALLLPYLGWLTFATFLNENICKRNPTDTKFGGYNEARLQADLAKLQQQAARFANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH67</accession>
    <name>A0AAD2JH67_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS11944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH67"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000002">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1949137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="174" mass="18647" checksum="BACBB8FEDD96BF72" modified="2024-05-29" version="1">MSAENPVVFFDITIGGSLKGRIEMELRADVVPRTAENFRCLCTGEKGIGRSGKLLHFKGSAFHRVIPGFMCQGGDFTRGNGTGGESIYGEKFADENFKLKHTGPGILSMANSGPNTNGSQFFLCTAETAWLNSKHVVFGKVISGQDVISAIEQVGSDSGRTRVQVVISDSGQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH90</accession>
    <name>A0AAD2JH90_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="97" mass="10551" checksum="6F344039B641ED1D" modified="2024-05-29" version="1">MPSMLSRPELSRRPRKLYNQSSMKNSSGKLSQGSPALSTRSSGSAAMHSNSSSGGSSPKRSSYYYLDSSTIPLSIESTQIPRVESETSESWGHFVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHG1</accession>
    <name>A0AAD2JHG1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001779">
        <property type="protein sequence ID" value="CAJ1951072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="495" mass="55201" checksum="8D066ACB7FFC493A" modified="2024-05-29" version="1">MSASQLPRGECASILDSSVNKKNTAEFTCLNGLISTPLVEQYLFHNSQLPQPHVDRMSPEEKKNLKAHVPGDLYHNSDDRKAVATKLKSEDPAAAAEFKADPVHYQARQILRNNSNYPNNMIKDKEVVALKIHLEKFCVKLARKIKLKVESVLVLEFNILNLKDDLGNPLQTSSLDNLRIMATSKEHGSAVREAIEHLFQYTLWPAIGMRGAKHNRDALAKTLSEAANLVFITSGKSCIIKQIGDQLTQVKRKVMGKTGKNKKKSPQSHEQRPPLAPTTTRASIPWRTNSTFLTNAPPTHDQAFTPDPAVNYLKTSPPCNESNFNEISGDNLVGFGTLVSDHFDGIPTGPKNTPVDEIFYSDDNDTIILNGPFETKDLQKSELTASQERNPKRLFERQVANSTYNNTTRNVSAVSRKDIDAIVAHGVTQQNLLVTTSNAPKTKSQEEKITKGQQKKPLETAMSKNADDPKQSRDHAEDPGFRFDVLCIRRSWNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHR1</accession>
    <name>A0AAD2JHR1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1952002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHR1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34730:SF1">
        <property type="entry name" value="PARAQUAT-INDUCIBLE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34730">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="655" mass="71530" checksum="40D9F1F1E042EDB1" modified="2024-05-29" version="1">MEESKSSPSSSPSSSKTKRNINSYYGHKVGFWQSLSLILNAGLMVYAHIGLSGVIFTNQDPSAASGGSSDTPVIINGTGVCTANDISIWNELGGEAMRPIHSTFCSREFTQEDTGGALCLSNPACIATCFQAQYNYSEDCSKCLGSIPQCAVGDGCLLVCAGDSLGQECQDCNADCIAQMFVCSGLPQETNGTTTTADATATATANTLGVRRFLNDNTTTTNDDDDVCNDWDLNNVPIWYRVYDLTFVGSVNDAWNGDAQLLAVIVVFFSGFWPYAKNVILLIVWYLPMTIEWQTWSILWLSRLSKYTLVDVFAVVVVLVGVQLQLNVGGTEAIIRAEPRFGILAFFVATLWEFIQIEVIKAMHEDKVLNLHKHANDGNDATNKENTKETANPETTASTTATTTDAPAIPAPTPTSPTTVRLYFDDRLEICAVLWGLSVGLFAAGAVTEIVQFTSKDLTATEGCTTSYNLVTLANAMVNELGLLDNSVAWQTWVLYIVYLLLNLAFPILVHLMQLWSMVNWKKWYQQKGQEQQQQDKQLLGNLQKVSLWTSAIWCFACIEILLIGIFAVEFKFSDLVARLAGDSNAVFLDITSGLGAGFYILLAYSFIAGFLQFTLRVIHDDPIMPSSCNDADDDADAEEGAVSSIQEKDTSDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIV0</accession>
    <name>A0AAD2JIV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">subtilisin</fullName>
            <ecNumber evidence="6">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS14795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041978095" description="subtilisin" evidence="9">
        <location>
            <begin position="29"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="158"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1954200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="527" mass="57074" checksum="99D18E2EBD29B48C" modified="2024-05-29" version="1">MILRHTNLFQFLILQSLLLSHLLLTAQAQEQEDEEEYVRVLVGFHDVQQEKEYVRRQRMQPRTAGRPKSKINYTFKQTEALAMQVTLSELEEMKKDSRFSYIEDDVLVPVAGFSNPTNVTALVEETHRQLAEATNYGIELTQANRIISPDPDYQECAVYACVVDSGVFIDNADIPYSRGDGYVDGATFGDAVGQDWYYPRGTSHGTYVGGIMIAQGGNDRGVVGVIPQGPQRSNVCLRVAKVVPDGEGVAFVSSLLEASEWCAQEAGGKPLVINLSFALGFETAPEAAIYNRLYDQGALIVAAAGNAGGTELMYPASHDSVISVAAIDAGSRRTDFSQYNDKIELSAPGMDIQVLQAQTNEIKVTRGTSLASPFVAGLAARVWAAVPRCSNKQVRQALRDTARRLGSGVPNREYGYGLIQARDARDLLVNSGCNAKEPTSSPSMTPSASPSAVPSPLPSQNPSVSCLGYLESCNSLNVCCEGFRCARMTDSLDDSLVCRRDTFSQSRPRLGSTDEKVCRGGYGGGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIY0</accession>
    <name>A0AAD2JIY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIY0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042242680" evidence="2">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="205" mass="21280" checksum="E85349AD6AEEA566" modified="2024-05-29" version="1">MNFSQVALIAALVGSASAFTPVSQQGVSTALFNGPTIGAGGMADTRDPDALEHEDARKSISAAPSFEEYLKMRDGGGAAPAAAAPAPAAPAAAAPAPVAAPAAPNASGLSYGKYDGEMWDMDAKTEIYNAWDPNSPRSPMNFNPFETWDGNSPDASGFYPGEGRYKDPARPNVNFEIMMAERELSDARNANPKPGDVPGCPGCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJN7</accession>
    <name>A0AAD2JJN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS16461</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJN7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042291281" description="Ionotropic glutamate receptor C-terminal domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="11">
        <location>
            <begin position="217"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="606"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1956919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="659" mass="74917" checksum="1D804B836D1861D5" modified="2024-05-29" version="1">MDTYNRWLFAFLFLFTASNYECLRKPSAGSILFAAAQDKPTFTTAQFSNITHRTFVCDRFASYANGTTDIRDLLEGLELSVGIVDQGNDIFFRLNRSDPDPNNWFINEDDPGIFVKILDELAFRGKFTWRNSFAFVQPPRTLDINPATGSNFTWTDVLLDAVTRYDFSFAEWVHNQERRRLGISFPVGWFDASTILVQNSVEKVAEFEYTAFLRPFSTEVWYLICAVIFFSGIMYWMIDKVEYPDDKINTVVYDTFLTTLTFTQHHQYWDPSTHGKRIFGYSAAFWALILASGYTANLASFLVAQQRPVLLAETLEEVQQKQLPLCVRAGAAVYGQVSRAFDKVDFRPENDFEAVYSSLRAGRCDLMASRAADFDAFKNDNSKNPDCSLEWVGRAQFVNKGGPGTLVDTSIYCTSVVRHVLDVHMHEMISEGRLDFLWKDHLRSLDNYQICAASTLDDVQGLDGDYSLQVTDVGGVFVFHGILIFISIVVTLIESPWRRKRHRKKAARAAEDDVVYEEKVRPSMESLSKMRSMKNLVGAEMSNFYQVYSDKDDSYALTATDKIHDSIRLDESFQIPPDGLLRYIQTMQATINTVQMQVEAVQMRKLQGEDGMDNPDETKKLNSRLSIIEDENEDGPTADDDTPPNEDDLSSGGNPNEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKA6</accession>
    <name>A0AAD2JKA6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="830" mass="93714" checksum="754AB6A406F9625B" modified="2024-05-29" version="1">MQSSNNRPSPSKRQRMETSSHDGETQSEDDWSMFRLFQELLLNGTTPQTPQDMPMQINPSSLPKSLLQSGQLRNNISKWSTIFVNHGFRTSLISSPRQGISVYKDSFALEDVNKTDMNGDSSTVGRIFLVAMFALHPHQEEMEKVYKMYLRNLYSLFLFCQRMRQVSRKDGDQLEEIVREEEKLLCGLLLLSKKPTCTREGIEDERRKRMEEISASIPSRIPTFLQEIHNAHPQQHRIEVLEHEYQRICSRTSTLSNALVTLFQSQHQSSIDNMVFKASPSVSKYERIAIYLYDAELDHKKPPHFLFLPSLHVALTKGPGTIVETMMDFFWSQMLNQGYYATLALKRMLHNDLANFFRSGLTGSISLPLLQMHAHFAPTAPLSLYLYGKAGSGKSSLVRNFPSALEATIERFADSEMLVRFVKQNLNKKHETLELELELRPNNNDLSVMSIIQGRRMTMGQSKPGLVVVNLEEMPNNEPAADPNQLQVAKLISQRFGGRTGDYNKQSKVPRNSEKRGIQNDASLVTLFTSNYILDPECLEAMKRLPLFNNLSAHEIVAVSGADRMAFAQAYLQNCVNNHITDRKVTTCIEGTMQINAGDTRPIVRHLRMLAAYIGELVPVASIDCNGSIQAMVKHVDSRWRVQVGTQSLELQVGPNLNLYPTNEALFEFKRCKSVNLLRQKYGTILGEKELHIILNFWLSKTLAPAVIVSNKHGIINRVLGAVRELKGVTCFTGVDSSKYKMTKSLYDPRDTPNLRDDILKVGRGATVAVELNCPSSDSQLCIREMIEDSPSMTAFSTSRSALHKEGLLFLIHVTGTITPEVKSRASIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKN7</accession>
    <name>A0AAD2JKN7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKN7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="154" mass="18018" checksum="AFAC06309F06C6D6" modified="2024-05-29" version="1">MQRTSTRHLPDNEKLQNSKEMIQKSSKGNEQTIAKLEAKLASIKEREEELKVSKEELKGAQIWNEKLQKNNRRLQSSIEGNEQMIAKLEAKLVFTKEREKGLEEHSKQHENAHESLAKKYRAFEVKLQDAKDCFENEAKRRQQVEDQIESILAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL91</accession>
    <name>A0AAD2JL91_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="393" mass="41389" checksum="5E9E2B26A13444A6" modified="2024-05-29" version="1">MEHESKNDRPDVKRISSLNRTDHTGNSSSCTAYNNVMDLVFNEKWAAIHPSRQAVEDENTSLSALPKPAPQGETKPSKESKLCSRIIPGAFQIDGIGIEAPRISLSSESHDESESSFEDSGIFLMPKANLIEQGLKDVEAPSAGGASSMTSVQMDNIPVAIAQKKDSRCFRCCVIIGILSIAGLLIAAISLLAQEKEGEAVTMEPIPAPTLDPNSADLQSGLSTVSPTDVAILNGDRGDTSDSDGGTIVTLSPSPQKDLSHKPTIAPSHWPTLKPVIPSTPSPDPETIRSPTLQPTPNLTPGPTSNPTPDPTPGPTRNPTPNPTPNPTPEPTRNPSPNPMPNLMPRPRPTRNPTARPTSAPTKAPQPRPTRRPGGDGDGGGNGGPPPPPPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLA2</accession>
    <name>A0AAD2JLA2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001999">
        <property type="protein sequence ID" value="CAJ1959449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLA2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="29050" checksum="073BE6B39553E644" modified="2024-05-29" version="1">MSHKGFCVMLCQCQSNLHLLDRKGKLPRAGRVKHLLWALYYMKCYNIEQVNKIFTGTTRKTFRKWTDIFMEALADLHENVIRFEYRLINDNGAPAKVTVDGTDFRSPEYSPFNPGRLSHKFDGPGFRYEVVIAVATGLICSINGPFICGEWPDIKIARNHLHEILPQGEYYLADAGYRCQHSPSITKFDIPDHERETMDELMAYHENINGKFKDWRIMSDRFRNSEEKHGGAFFAVAVLTQLEIAEGMHVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLH0</accession>
    <name>A0AAD2JLH0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002064">
        <property type="protein sequence ID" value="CAJ1960565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="230" mass="27177" checksum="EDF4B3B398EF32B5" modified="2024-05-29" version="1">MRNQLHLRNESITREEMNNNMKSGQFFYEQVVEIYNDPTQCTEPISPEIDDSPLDEIQGTFHWTEAKAKFNSIVKLYESARRVWKTSGNHGDFAEYTTADYLLHLHAAVEKYPGCLSQLCSKLPEEHFNESTNGSKAMPPRYQSGNTTRERKRNSDTIEFIHSPEVVELSKKKMKLLEEQFERQKEKAAAKKKEKEEKKKEKEEKKKERKEKEERKKQKERTEVLSKKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JME5</accession>
    <name>A0AAD2JME5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002168">
        <property type="protein sequence ID" value="CAJ1963919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JME5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="180" mass="18701" checksum="5112186B16BD2417" modified="2024-05-29" version="1">MSWWERRNSEVDDIAQGYADELIATDDTIATNPKFFSEPSSSVNDGVSTPRTDAPCADWRKTTYTSPAALPTGPRPSDNSYSKNSKNGSSPPPLLHPSPTSLGPFFAPSAPLATSLKQRLRGTASTVCLLPPSPKSARPNSALAPNASSKAFSSTAGPTSSNNSTALAVVADPVTAGLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMQ3</accession>
    <name>A0AAD2JMQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS20708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02930">
        <property type="entry name" value="DCR_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051793">
        <property type="entry name" value="NADH:flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42917">
        <property type="entry name" value="2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42917:SF2">
        <property type="entry name" value="2,4-DIENOYL-COA REDUCTASE [(2E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="10">
        <location>
            <begin position="52"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="456"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1964596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="793" mass="87544" checksum="43F3EC08347F44DC" modified="2024-05-29" version="1">MIHSRKLSKANPFCLRTTRITNRIQPSSFRRHKSSAAVSDHDDFRHSLYPHLFEPLDIGLAGTLPNRVLMGSMHTGLEGHSMPMWMERMIFDKNASHSLDRMAAYFQARAEGGIGLMVTGGISPNRKGWVGPFSSQLTNESEMEQHKVVTDAVHSVQVPVFGSDDSITSRICLQLLHTGRYAYHPFSVSASSTKSPITPFPAKEMSRSQIQQTVKDFTNAATLAARAGYDGVEVMGSEGYLLSQFLSPRTNHRQDEYGGSFANRARFPLEIVRSIRAAVNPDFIIIFRISLLDLVEGGMSWEETLELAPALEEAGVTILNTGIGWHEARVPTISTAVPRGAFGFATKKLKESNVVSIPLVSTNRINDPLTAESLLGDNASDMVSMARPLLADPDFMSKAMKEEANLINTCIGCNQACLDHVFVGKTASCLVNPKACHETELVTKLLPESDRLTIGVVGAGPAGCSFSIAAAETGHNVVLFDQDDKLGGQFNLAKRVPGKEEFHETLRYFHEQITRSDRIELKLGTSVDYDVMLQKSNDIDKWVVATGVKPRDPKIPGQDHPNVLSYIDVLKGNKPVGKRVAIIGAGGIGFDVGEFLLHHEKDKTHKDVSIPEFWEEWGIDEKQEHRGGLKERRQSEPKREIHLLQRKKGKLGAGLGRTTGWIHRATLNAGNVNMINGVNYDEIDADGNLHYTRDGKKEVLEVDTIVLCAGQVEHRELQEMAVEKDQPSVPSKYVYTLGGAYAAGELDAKRAIDMGARLAARIHQNDVAQGNHVFKAPPTTEEKMFKLLRKFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNN6</accession>
    <name>A0AAD2JNN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS22665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051158">
        <property type="entry name" value="Metallophosphoesterase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="185"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1967206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="508" mass="56790" checksum="E2E71A949EE4A268" modified="2024-05-29" version="1">MSLASMEISSTEEPASTGGSFWQHHRSTILTVILFVILFATGFFSALVYMLIRYLWLRLVRDPFLSPTDNLPSVLWEMFTTCPPNSKRTWPTIFFLVNVANEDNKSDDDDDNLQADDDNNDIMEQEREKAKYLDENRREARQRLVLIAIFYAIWTGLSAYSAYNPKLVKLTIPVPKLPAACDGYKLAMASDLHLGSMSGVNEAKFMVQKLNDLEPDGIALVGDVGDQTVNSVLKEKLAPLADLKAEDGVFYTFGNHENKQHVEDYRQLFRHEAPFKDKIVLLENEHTILSKGGMDGCQILLLGMADWSGFGTLRKRREGQVEPSLTEALHTTPGPDGTSIHVEEGPSVEDLPVIMMQHQPKNMTGAAEFGVGLQLSGHTHGGQLWPQHFVLFIYDAISGLWEYDVGKKYGPSYLFVSEGIVGYGPRLRFLSKTDYALLTLRSPAFMNADGLEPDTHITYATMAMYFAWIVFPISLLACMVPCCCWAKSGCKTYQPTLGRSSGEGRQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP04</accession>
    <name>A0AAD2JP04_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002385">
        <property type="protein sequence ID" value="CAJ1968478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP04"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="263" mass="28829" checksum="440E463BE7241120" modified="2024-05-29" version="1">MSPKCPDRLLPKIQWKDPDQYVEYGKKLNLNQIGATVPAIVPAIVPGASSSTSRASSVAGSINTPLRLAGTTGNQMMQVPSGMQLIQIPTQGGGTVAVPYSMNANGWEDWLFCYVNVYLIPCPAGMTNVKLQADWHYASENEDLPDLATEEDQGMQFIQSPRREKNPFGLYNHVIIDSGCTNTTICNGELMHGLRHAEKELDMQTNVGSRVLDEEGFLGRFPPPVYHDEDGIANVLAVRKIIAAGYRITMDTDAGQRCSLPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPC9</accession>
    <name>A0AAD2JPC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS22841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002336">
        <property type="protein sequence ID" value="CAJ1967586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF81">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE CEPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1025"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="745"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1967586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1299" mass="140580" checksum="E5FE54246937C52A" modified="2024-05-29" version="1">MSSAPAWKKATEKEQSVVYLEEEEDDIAALFFGDGGGGATDDNDSEEEEEDAAALYFAEQEAKAKADNEGAQDDESSSSSSSSSSDDGSNDSSSRKSDNSGSSSGDDDSSQKENNDDASRSSHSNSSRGSENAGNSASGSDSDDRSQRSDGSSRSGSGSEEEIELSEDDDRSRSDESSRQSDDESSRRSDRSERSSRSGSQSENDDGSRSKSSDSGSERDDSGDSASDDGSRSTRSSRSSTSKNDSDSDNGSRSKRSDGDGTNSDASSRSSKSGSKASADDESAQGSNTSSDDEVEVSSDTGRDDTKGKDKEEIKEEEKRENAKPASTPAPFPKPINTKPVKSFPKVATTIPTTKAPDVKAKPAFIKSEDGLAPWQSELKKRKETGASLPGWKKPKKEESTIYVEDDEDDIAALFFESAGGKPKSAKFSIGGAGQNTTGLGNDDDFDAAAMFQSAGGQAKAATEHSNEDDAAAMFQSGRQTEAAVAYSDDDDAAAMFQSGGQTEAPVAYSNDDDAAAMFRSTEPTKAAEDSFQNHIESDPSEYATAQTENQEPDPMPANSGDEEFVEVWDDEGDAGDEEVLEEVEIVEDVEEDGGAYTEEEMIVEVEEEFVDDETVGTSNEQEIERRFAHKSAYDEMDKTESQMRNYIASLAHGESARSLHSDQSSVPWGMPTIGDDDNATRYAGYVQAARERRMDDQSSFFRPDVEMPTDNSIADTETFASSEQRSIPWGLEVREIDSWANPVRRLQPTKKSEAKEDTDTINKESTSVLSTKSKNAETAPTISRKAPKGKKRRAPTGVGEMVSAEVYKTSVPNPERETELWYHPGFAFLSQNPNMGPYYAPPPPKISQSNSMNESEGTDKAIVSDLEVAQYMYNTNVPAISKVTLLSYGQETISQWNKLDSFGRRRDDQSLSTSSESTEVKLPDLSKTIMRTASAWTPNGRDDSEASSESLSYDMLVPFDDEGSDEDKRRNVVFSRSGSSVSIDLEVETFEYVPESSLSLRPESESTLESSSVKSTRGRLPCGIYGFVSCCFFLVLIPTTVALVLLMTGQNNEVAPRTTNNNFTSPTGAPSMAPTLLNEIMEDTSDAPSSGPPLPTMQPTVFDPVVEEPVTEDLLFRLLASASVDNGEALRNRRSPQFAAMEWLRTPAGFSGVSNDAVFLQRYALATFYYSTSGESWTENDLWLSEADVCEWFSSGGSLLCNNDGQVTALTLTNNGLDGNLPNEIGILSRLETIMLSGNTQLIGSVPRTLQNLSNLRSIFIEGTGLSALPPEVCDLPLQDFWANCEELGCTCCNECFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPS5</accession>
    <name>A0AAD2JPS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002472">
        <property type="protein sequence ID" value="CAJ1970178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="407" mass="44925" checksum="7BB9C3FA738FF255" modified="2024-05-29" version="1">MGSMATVLQDPVTLTNCVLIDHDDFDTYRASSAFIVFRSRTIPQPLVSKPSRRSPAEEFDRGINLDASLYPTLSNNRQWDSHHDKRLTSEEEHPQYPSLAEPFVPDLASVDLGLDLEPDPVVDLKTKSRHGTLDLSSVDLEPDPIVDPETKSRHGTLDKDHVQYPCLVEPVATDLASVDLEPDPLAYRACLASLATLPCKTSLCTAKLEAAGSNNQPPAQPPPSPQHSVNFHEMLTTTDFLSQFQHSSMGRSENADTLTSVTSEETKSDRLALVPATKYREQSPFDRVDILTKSNTTVTTLKDSPALDDAIGFFETHHCVMPTNGLYKLHPGQASDLDWLECNMAGLFDLDPAHVPQLRPPDFEAYKSGRQPSVLFVPETPINFVIESTPLQDKPIDLTCKLSSSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV68</accession>
    <name>A0AAD2PV68_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS14721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV68"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1954126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54927" checksum="AF24CC79D4BB540E" modified="2024-05-29" version="1">MKYKSEVCPYTKSLQSCIACDACGIPNPPSRCATCQMTYYCHEACAKNHWQVHKSYCKSPKDILQQSNLILAVECKSGNDKVSPSKEPYSHSVKPSGETSTTPESTNISCDMCKIECKAPLYNYKTSDSDVPCCDLRFCLSCINHYETISTSLVTSSSSSNSSSNANPKCPCCRSTEEPNADVANDNDGENASTDKRKFQLLQAALWAAKAASASFLIESDGTLANEKFRRQPHQHPLLVKYANKGLDFVETLLDEDSSNTAAKVLQGRILGLIGAPDLGLTLLKEAVTKLFKSSSSTSVPVDQQKKVDELMEQVKQHMMVAEMEQAEALLEEIQNMREQKFVLFVQPNDIMEVRLTIARLELQNKDFVACLAALKEIVAIASSEEEEEDGSSSAASSLTPDQLLNAYLLFAKCFVEMKQYDKALEASKLAIGMNRHYPRVYKELVEARYAKGEVELAKGAAGRAVLYETPWDEQMKRSVQQTYADLFGDPIYTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVH9</accession>
    <name>A0AAD2PVH9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="634" mass="69033" checksum="522E69A3B14C8082" modified="2024-05-29" version="1">MSQTIAPTGVSPPPSITLARSLATGVDELSGMGPFDLYKEQMDNGNTEAKVDAMKRLPVVAFALGSAKMQSELLPYLKTIALAQPPIEDELLLLMAKQMETFVPALLSDAKEILELVPIVERLGSIEETVVRNQAIALMNHLCESLEKVLPLDPSIVSSLVSMSKRLVGADWFTAKVSAAGMLPALYTVSDHADLPYLYKELCVDETPMVRRAAAEHLGKMLKALGNKDKANELIPVMQQLARDEQDSVRMLALASMSDVGDVYCDVPEWTKEFILPLLKDASTDLSWRVRHHLSKVFGKVAQSLGFQGKPKFINDQSLVMACFVSLLADVEAEVRAAAVGHFATMVHWGGSDLFVNHLLPLLPALADDVVMEVRSKCALAIMESSEGGTLEDTLIVQSFGPLIEGFLQDEFQEVQLQVLGNLHKLSHLLHGMNGVVSSILNMSKATNWRVRRGVAKLLPHLAEARGLDFFANVLMEPAWLVLLLDPVACVRVACVEGMSVLVKVAGQEWMSQQIMPQHVRIYSNAETGSYLIRITILQAHAETAKAVQENPGSGGSLWMDCVTHILKGMEDKVANVRMVAAQGLAKVVTADDADQRAVIESQIIPALEKQLADETDMDCQAACAEALEAAQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWI9</accession>
    <name>A0AAD2PWI9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS19025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1961071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWI9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042171116" description="GOST seven transmembrane domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="9">
        <location>
            <begin position="443"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="722"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1961071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="747" mass="79408" checksum="B9BD2B2FFB7324B2" modified="2024-05-29" version="1">MRILCTLLSVSFVYLQVARAEIVPLDLVLDADSEEVHYVRGWLEAPASIDISNVKFLTSPVPTEWETDDEEADDDEDEFPYDETPAPTPFQERFPTPSGAGTKSPSAPSSDFPFPTASPSNSTSDGGDTGGGGGGGGDLPFPGDNGGDASDLPTASPSNSTSDGGDTGGDGGGGFPGNNGGGTFDQPTASPSNPTSDGGDAGGDGEGSDFPFPGDNGGDTSDSPTASPRNPTSGGGDGGSDGDVNAPSTGPVGDGFGDDGDGSSTGGDGAFGGDLDGGGGGFGGDSSPVPAPTGFPRELQGVTQKLHFVLFAIPDNCKEDMFGNCDWTALGVGATDSLVEGDISYCCSEDTASRNICEEENIGKLIVDPVLFAGEERFLAVPQTVNTPFDFPEGDSVFHIKEKGDYVLLMGNCFDDGLDVLEMGTMEWKAENRGYVPGHLYGLMVFYAALTVYYFVLAFFYKCGMRMFQDAAIPIQKYIFATILLGFLEVLCRAVDLGFWDVHGQRSIYVLYAALGLGVLKRGISNSLGVMVAKGWGIVRESLGLALAKIIMLGLIYTGLTGFRDFSLIVAEEDVEKISVTEETELFDIALILTLVIMVLDLIFYFWILDSLNATTDYLRNMNQTSKLRRHLRLRCLMLTSMSIAAAWLVFTIVDKVMGGILRRDQKWFLDGVMQLNYTLIMTGVAFLWRPNANAKDYAMQMEIPTMGEDDENDLELSCVVPSAGDMDDGNDPDHPSGIKANMGQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXJ8</accession>
    <name>A0AAD2PXJ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="849" mass="94422" checksum="EE40EB2E46A77EBE" modified="2024-05-29" version="1">MNPEVFNDEDEAAACEDVRRMAEALSPQMSALEDILKDYSAESDVDMDHQPQSGFLDDDDSIDGEMERLLTSEQSLRDELQFAEDLNAMMTPSRAEGNGTTNQFSLETLDSVQKRLYEDPPDNEVPSSYTLDDHAGYLKIRTEKVGGWYYCDMTKYLAPAGADDNELVKDYCLPVPFRKLKRLYSGLSYQEVAHSKRSSLSTPAKLLQTPTKVYQAVAGTRTPRASLTPITPSRTRTPGNAPATPSTPMPPPPPPPMPQEEPLPVRTVAIRLRCDVLCGAVMDAVHHAFDVLPEDTTSQIIKRQGGHLRGAVYHASKSLAYVADIQLCTQKSDALERRLIVRYYHVQDDPEAMNELGQALQRKKKIEPEEVTLETIGDGGAEQDLFGNQHMKQSCSLIQRLMAAQQGGGASKMDQKQQSSWLGLQNFSSYESKSEMQRSIGRHLLSNFKACPSVREENKKANPTIRRLTLPSLSHRDWPLLEISWEFTRIILDELDNRDCTFNTLSTLPFGQFPCLPTLDVHYCSQLRRISREAMITQLLKSAKELEDYAKTAQYNCAVCITLLAPMLDLYGIPPMGLPQVSKPLDHYPLEFTPPQVSCPPWGSLVMEALNKVAARTPTGEITDDEAVKMVYQALVKQDDEEQAARLGRKNAQIMDRLAKLQSHQRLLVTKIRDSHAFSAKAKAEADSYLKRAQAASNEGTQAFPSHLESSVPLLSFRISLGASSSGYCYVTPSQILFTTKSIPIVGGKTTTVFDLEKVDFQVIEGATSTLLNPFPYTMNVVSKRSGQVFYGFRPAVGPVRLQKFLSVIQSFAGEETPDEFSRVVGNVQAVEEDGDINLSEPQSDELSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CB41</accession>
    <name>A0AAD2CB41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS273</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1899287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CB41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="10">
        <location>
            <begin position="170"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="10">
        <location>
            <begin position="338"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="11">
        <location>
            <begin position="539"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1899287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="963" mass="107709" checksum="D8B1D57C0D23B8DB" modified="2024-05-29" version="1">MNVAQQPYDERVALAPNSRPQYYYVYGSVEGDDHVEPGDHDPELEDSLFGEQLITTDHEDEVPARDERDIPHLVITNGGEKNNQYYHGRIMNRCWPYRIGWVPIISLLIVVGVVLILIVIPKEREPMRAYGFVPYGHVDRIDYGDAVEDILSMDLFHPTLISDTKPRAFKFPFPTGAFWTNLVMPTDETDGLSFPIVVYPYAYKWADSGLQLSYPAAHRTVNSTGVHDAFKPDVTIHMVEESRNRYVTKFDPLSVTLRFVSSETSKWETPLVQGSPYSTFRVLSATPVFTSLTTFKSIQCPGADKEMFNDFTDNDDDYRRRLFGVCSIDESDKKKTTIRGVQFIFTSAEGLGWIMFASEPMILEFDTDDRTTIKASTQFTGVIRLAHIPTNSPNEKTTDSDTSTGLRRLIYHAGVYPTGCHVSWDFHSPSPSASSATNSQTPGGGANTVRQASVTFTFGTQTMLDTSHLPSEAAKQLLMLALPHHVEKLPSNVLLKPKKFDLTFRCIKGKMTPVVGGTWTYTEPLLDIGLNSGYKDVDDDVYEILLQQIDDDMGQLLPTTAENIYGFGKQIARLAQLTNIAKRIDREGATANAFLTGVPDRGIALLTNYLEMFLSSQVTDKLLFDSNLGGLVSSNGLLDTEEDFGNGRYNDHHFHYGYILYACAIMGKLDPTFLDRFGPNVDAIFYDVAHPLNGDATEVQPISLFFPLARHKSWFDGHSYGTGLFPIASGKLQESSSEAINCYFGAYAWSLVRHSTVHVDSDMTDFARLLLSTEIRSAKTYWQMVPPTALGVPGSAGVYNREFEEQYMVGNVGMLDVTAKTWLGNDPLHVHINNVLPVTAVTAAIFSPDYVRYQYPYLMKNCKDVEMTYKGYLVVLHAIINTTEAWKEAQELNSWELEKSLSKSEVLYWITQRPGFSNPSLDADDFDESNDVGSASCESHPKCSNITGFCCPTKESVYMGCCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCC4</accession>
    <name>A0AAD2CCC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000042">
        <property type="protein sequence ID" value="CAJ1928396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="187" mass="20866" checksum="34234559746FA423" modified="2024-05-29" version="1">MRKDVECTFGIITGIPLHGIEVCDRIWLTCCALHNVLLAEDGLDEGWNASRYLGGEDGDHDRDDICDLFGTALPQIPPRVVEDMLTHDSSGMGVGIDCTNKESDDSDDSDKDSDDDNGDAMDFMAIDDKTVAVPAAIPVCTLSLKSFRRKLIQHFDILWHRHEIYWPSRIGDKPPPPINKPNERYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD60</accession>
    <name>A0AAD2CD60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1912457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="9"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1912457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="183" mass="19149" checksum="8A6C239433770B57" modified="2024-05-29" version="1">MDGKDALPRLPAILALVPIAIGIAAASWDHPTFEPLGLIAAFISCTAQSLLNILSKKVMTKSNIPGAVAQRAMISVGLVIVGLVSAFQFAAAANAKDPVKGQEHPPSLLAGAAATAYHVEYLLSFTFVKLVAPITYSTCDAIRRLGIIVAGHYMFGGHPFSTMNILGMFMALSGAATYAILNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDU4</accession>
    <name>A0AAD2CDU4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000136">
        <property type="protein sequence ID" value="CAJ1931299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="235" mass="25748" checksum="476EB03E40E1E167" modified="2024-05-29" version="1">MISLQETLNLNNKAVALYQSNDMGGAAKAYYESLCLAKELLTCTAPRRQGSGVNYQTPAPLATTLPQHECFHTSTETSINTPIQEKFFLYRSALLLQEAPSSFVGAEHRVQSMNIYCAGILFNTAILHHQKSIKTGISAYMHRAEQLYQASLQLIVGLPRSNDTLTLIAFAVSNNLAQIEFEKGLVMQASERLRFLVHLFCSLENTAGRVFAVDGFHGMLSNTLLANGMSSSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE09</accession>
    <name>A0AAD2CE09_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000014">
        <property type="protein sequence ID" value="CAJ1927242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE09"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1927242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="142" mass="15736" checksum="AFE4910A518F7A2C" modified="2024-05-29" version="1">MQSLSSTRPKQGTETPSSRSTSSDPLFCSGAFFLGGALAPMRNVTQEFDTRAICMSTSAMRDIPALTWCPEETSDNSDDDEEEMIPTFSLVRRKEERGQQCNETEQDASNITRSTPSRSFKKLSLLSRPTVSPIGEILFKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF12</accession>
    <name>A0AAD2CF12_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS1906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF12"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="15"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1930335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="326" mass="34201" checksum="CE734848D1A798B8" modified="2024-05-29" version="1">MCKPGAATPSASPVKLATLVGLWYAGNTFYNIYNKQALNMIEAHWFVASAQLVVGIFISLAMWLSGIRKMPNLSQSDIMACMPIGLFASLAHCGTVLASAVGAVSFAQIVKACEPVFAAAVGVLVPPVDVKPTLAYIMLIPIVGGVGLACIKEGKGVDINVPAFLFASLANAAASLKGKLGGSVTKSLKSDPSKNMDAANVYGVMNIISFFFTIPFVVFTELPTLSETFAKAAEVHGADAIIKNIVISGLFFYFYNECAFAFTSLVGSVTSSVLNTAKRVIIIVVSSIVFKEAMERNTVIGSAIAICGTFAYSLTSKKPAPKTKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFD4</accession>
    <name>A0AAD2CFD4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ubiquinol oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS989</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1922689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFD4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF19">
        <property type="entry name" value="UBIQUINOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042205406" description="Ubiquinol oxidase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1922689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43693" checksum="C01572427F0E80EF" modified="2024-05-29" version="1">MQTKPLLLIVILSLTSVTSFQSTAIRRAQYANPSKLRSQTVKDEEISEEQSSTPFLEDDDGIYFKKGVGGGSNRPASAFILGSENFVKQSKAIGLQTLAKMGLTGKDFNPEEIPPQSLKLTLSNQAVKDAEVRRETQEGRVETNAVARLLYDVGCYVLDELFTDRPIARFWFLETIARIPYFSYISMLHLYESFGWWRGVQLRKVHNAEEYNELHHLLIMEALGGDAVWSDRFLGYHIAIGYYWALIIVFFFSPAVAYEFMELLESHAVDTYSTFLNENEETLKKLPAPAVAKGYYTSDDLYLFDDFQVSKKAGSRRPSCDNLYDVFQNICEDEAEHVKTMVACQDYARVGKLVESPHVPAMKRKTGSKKDEEDWGSRNDEMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG49</accession>
    <name>A0AAD2CG49_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000313">
        <property type="protein sequence ID" value="CAJ1933926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG49"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="75" mass="8934" checksum="FC0266C31AAD1CD7" modified="2024-05-29" version="1">MSGLYTETSEKEFKTIETNYFGLRTYQLDRKKNFLCFEKEQIQESSMPIPCWKEDCRLSPVTCNRNPPRSDYHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGJ5</accession>
    <name>A0AAD2CGJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000209">
        <property type="protein sequence ID" value="CAJ1932131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="153" mass="17793" checksum="44DF7F0C6E9199AA" modified="2024-05-29" version="1" fragment="single">MPKLKLYKTSVSSKTDKHLYTEEMTLDEPLKIPHAEKNEFGKSICFKLPNDVLHCTVYPLVRFDDSMEITISPDGKFIEKKLLKRIPKDASELLNGAVDQNDLLYASAEAEIRRMKKEMNEWEKVDDDPLLQFGEEMAPFFVDRHGRHQDSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHV1</accession>
    <name>A0AAD2CHV1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000009">
        <property type="protein sequence ID" value="CAJ1926962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHV1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1926962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="263" mass="28687" checksum="C6E3255B166D79C1" modified="2024-05-29" version="1">MQIDSTATQGTPGRQQPPSSSSFVPNSANTCSFSNPTQMSPNQKTAPLFPQPGFSPPATVRAPENMTNSPAPSLASTDTLSLFAGGSRGVNYDREGTAFNRHQINVDFQFPEAHKGFIVEHNPRKVCNGYHCQTMVLTREIGMEDLQSQSAYMHDGCIIFQGPTRPLHIMKRLPNLPENPLAAKSDIRNVHHQTVAHLKLSPMCGTSFWKMVIPEDWELDNACLSNDASEVVMTVLPLGDNVNSVQVNAPLAHGRLLESAPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJK0</accession>
    <name>A0AAD2CJK0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000524">
        <property type="protein sequence ID" value="CAJ1935894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1295" mass="140585" checksum="2E1E7155607C7652" modified="2024-05-29" version="1">MNSEESVAESSRKSRSSDSRSSHRNSTSPKRNEPRRTKRSEEELKAKEKARAERDSSVAGSNVADRTDVEAPIEGQSGHSTSKHKTGRRRGQQDRLTKADAATKAKEILDRPSQPVTGPIPGAHAASRGTDAGKEKLSGKERRKESKARGSDRTDAPIEGSSGHSSKHRAGKRRGQQDRLTKADAAAKAKSLLDSSSQPITVPMPGSHASSRGTQVDKDRSAKDSASKAKNLTINGLVPGAHQSGITTKKGRGSRPVSAVSATEESRVERRARLEAEKGDHLDPMNTDGLVTANAVEDTDGDEALELDGKGPKKAKSTATGIFVPESSENNEAQNGNSNPRNWERFKQKKSARICCCLLFIFVVAIAGIGAWLGTRNTNSSASNGPSQVESDTIAETNITDVPLETDPPTQDSSTFTSSPSGSPSTNVDVDFDPPLAEDCAAVANGTTIQGQEAMPVQRYKLELDATPFLPMELSVSADIVEEKFRELLALALTGCNRVVRNLRSLRSLEGSFVYAIGNVALNASGVEGVQCDEASNLRCHRINMALDIVVKDDSVKVVDVIGEVSAFLGDGVLAEKLELAGLYERIIVTNLGYIDFATPPSSNNVAPSVVPTLFPTAHPSLLPTQAPSQMPSLTPVIMVPRSTPMPSQTMSRNPSRSPSSVPSRVPTETPSEAPSNAPSIARTPGPTLPPTSPPTLQPTTAPPTPVPTSSPTVTCFRYNSELSDAVGNWFLDSAQSKASVEDTYGPIGDWCFGTGVTSMVDLFRDRTTFNEDIGNWDVSSVSDMSGMFQSASSFNQEMSSWDVSSVTTMEAMFDGASSFNQDLSSWNVSSVTSMSVMFRNAQSFDQDLSSWDVSSVTDMTGMFHLAFQFNQNLSSWDVSSVTKMPSMFQYASSFNQDLSSWDVSSVRDMSFMLEGTVSFNQDLSSWDVSSVTTMTNMFHTTSSFNQDLSSWDVSSVTQMNGMFFKASSFNQDLSSWDVSSVRLMHYMFAFASSFNQDLSSWDVSSVTSMNYMFAGATVFNGDLSAWDVSSVRDMTDMFQAASSFNQDLSSWDVSSVTSMNYMFAGAMVFNGDLSAWDVSSVRDMTDMFQAASSFNQDLSSWDVSAVASMTNMFHSASTFNQDLSSWDVSSVTQMNGMFYNEMSFNQDLSSWDVSSVRLMNFMFGYASSFNQDLSSWDVSSVTDMSWMFYSALSFNQDLSSWDVSSVVDMMRMFESASNFNQNLSSWDVSSVMDISRMFVGATSFDQNLCVWRSRLPSNTNVADVFFSATSCQSQSDPNLSGNLPGPFFFCSACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJM3</accession>
    <name>A0AAD2CJM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS5024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000546">
        <property type="protein sequence ID" value="CAJ1936073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1936073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7676" checksum="4198B4CA6F351AA3" modified="2024-05-29" version="1">MGQGASTPVEPPKPKKKLGIKTGKPICCCCPDTKKARDECVVFRGEEDADCIKLIEAHKICLRDEGFDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJV9</accession>
    <name>A0AAD2CJV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000435">
        <property type="protein sequence ID" value="CAJ1934981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJV9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20551" checksum="1AEC9AD502A16452" modified="2024-05-29" version="1">MKPKYWFNFDYQEDTKTIGGFPLRITEGYGANRKHGFEIDLTSKYPGVKIMIGTMKEFVKIEFIGASVEAFGSAVGMLGDFETGKTFARDGATVLDDFNDFGNEWQIQPSDNMLFHDISNPQFPKRCVLPEDPQGQRRRLLTEASVSIEDAEKACASLTDAIDRKDCVYDIIATQDMDMAGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKD5</accession>
    <name>A0AAD2CKD5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="226" mass="25553" checksum="C993A25170FB2F45" modified="2024-05-29" version="1">MSTNKRRVQFNPSHDSVLEISNREEYTEQEILNYWYTKPEFKAITTRCYKQASRWESGKSSKNESFHRGLEGFTQEAEEITTASIEQCIDSVMDEQDAQWEEEVDDCDRLAAVSKEVSRFSVAWALEKAIADEQDAQNIYRRMEQKTKLQLKTKSSKGSSGLDSSDHTSICSDLSHPEADSVRSRESSSGTRVNKKGTQSITRRVTKALKMPKLAVGASPLLGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKQ0</accession>
    <name>A0AAD2CKQ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000447">
        <property type="protein sequence ID" value="CAJ1935320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="172" mass="19320" checksum="4355A037AADDDC4C" modified="2024-05-29" version="1">MSPKPASSAATTAIVHYFFQAGVQLVAITAEPGGSDAVRQRLLEREVSKLDYEIRSDPEHSFLTSGPPTPPKDLFIMKDHQWEVSGDYKMVQPALVVYDADKEVISETTWSWKTMGLDDNNTNWDSRVDTQAWEGEADKKVLLVTMRPVMSDLLAAIQEKRAVKLASTHKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLG5</accession>
    <name>A0AAD2CLG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044518">
        <property type="entry name" value="ARF_GAP_AGD11/12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46220">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46220:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1937984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="402" mass="43051" checksum="73D564CAC4BEDA27" modified="2024-05-29" version="1">MPSLDERVDNLISKVDNQRCADCFDKQPANVTILLGSLEKPIGAFICFRCARVHEKFPNDVGYVLNARNEADWSEEEVQALEQGSNKIVNAIFESKIAYDHPRPDVNSQLDVREKFIVDKYIDRIFFSESKAAKLMKAPAKESSARFALKAPKDSGSTRGFNSSDSSGDFSFDTDDGLGYENSTPDVAAGVNDLSLDAAAAAPRQRRTRRRASIGINDSKGPPSRTMSLQVEGAGAANQNVRRQRPGRRQSLGRTSSMGGAGLAPGASGDAQGGAPRARRPGRRGSVSGGGPPSLAGSSSNLSQSGAGQTRQRRPGRRGSVGGGGPPSLDNHFNSSNNSLDISEAGDGNRSVASRDRRRLGKGSADPLGGSSHQERRRPRRRGSISVEDANAKLNEKKEMVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLM9</accession>
    <name>A0AAD2CLM9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000757">
        <property type="protein sequence ID" value="CAJ1938691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLM9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="225" mass="25738" checksum="A4917BDED7CAF016" modified="2024-05-29" version="1">MMLLNETRPTMATLSSPSRPRMMSFKRSNDQASRRIRSRYLHKLGVVDSSSSGSGSMSCDDEFSVETTASMDTLQTKGSPERKHVRRTSRPDEIQFEALKGSDGEDENDLSGPHMLRTLSLASETSTSSSVSFEQYVVVHPIPNLDAYSEDMKQAIWTNQEEAEIEVMRNYLEFASEGMQWQNTLEEEDFFEYNNELVHPVHIMNRHCSLKQNFLMGMSARRAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN30</accession>
    <name>A0AAD2CN30_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS1860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN30"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="442"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1930198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="564" mass="61505" checksum="A67F0B4DDEDEDC0F" modified="2024-05-29" version="1">MNLELLDPFRRQIPDRVDATLNLPDDLDSRLKKELNEGDGEDQMYATHVAFNRRGAYIAVGYGNDMIGVFDVLSRTLSGFYRNSNHEALMALPSKSTPIKKGLNFVSWSRRSRTIVSGSSGDTEIHIIDTTHPLGPGECCVGIVTDEKKEKIDDGDQNDTTTPETSSQNRTSSSFARRKKLEDHHTKTRYLSVAVVENNGISIGETGDKVVEKPHVSVTASSNKRYPSLAFALPLPIGGFLQAHPRLTSAGLAVLNDGSIVAFWVPSTGWEDYGDDDQAPSVKVATIFRDESHFITYAVVDPQGEKMYAGTKEGKIIGFDASAVFDQFEVASSVSNLTVGFVVSVPGRSSVWGLVISRNGQKLLINSADGALRLYKTTDCWATPEVVDKPFMVFQDVVSKAKFASCDLSGDSEFVVGGANGGDNKYELYIWNTSTGELMDKLTGATVDLLDVSWHPTRSFIAVATSDGVVDVWGPRINWTAFAPDFQALPHNVEYVECEDEFDVVEGSIDEANERAESCSQATDDVDILTIEPVPVFASDSEDESDVFAFETKVTRILGGIATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQG7</accession>
    <name>A0AAD2CQG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="69032" checksum="6A32F946BB66A6EA" modified="2024-05-29" version="1">MGQTRYSGGLKTLQYFVLWGTVVQWHCDSFVLAANDDNQRPENWYKKYEHYPPYCSIPKEMETRAVPPLPEVSRSVYGETRIQHVSAIIRHGARTPWSSNENCFPKFPVDITDTEWNCKLTTIMTPPSSLTIGEEEGLGDDSKGLDNSFFLFEKFYDALPYLKDGLSNELNGTCQVGQLLLKGYEQELKNGAILRDAYTYTYDTMDHDERMRLIELSFHEFSAWDPNHLRFRADADQRTIMSGQVLLRGLLENEAEAYFRDTGEYPTIPLHIADRERDIMGPSAKVCPRLDEIANRARQSDEYQTFNNSKESLEVNYFLDNTLGRMDDNKILDCLMITMCNDRDLPDVINDYGKPDSWFERIGALDIEEYNRVMKYNNSEHSRLAMGPLWAEMKDIWELFLRRDKRGKNPSGEDGTVPPRLALYSGHDTTIMPLLASISPDLWNDTEWAPYASMLLFEIHEFIDSWNTTLFESRYAFRMIYNGKVLTGQVPGCHADLELCDLQTLMQIIQPFATRATDCTSGAKQKAGYMSSVAVVNTKRGIMMFFSLILLGAIVGAIAAYVLVTGSLCGKRILSYTPIEDSTSARFGLRDAPSFSGPVGFQDEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS74</accession>
    <name>A0AAD2CS74_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001097">
        <property type="protein sequence ID" value="CAJ1941882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS74"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54739" checksum="4A3C515B01289AF5" modified="2024-05-29" version="1" fragment="single">MSTLPWNTQRRDDAVARGPHKSAKDEVSFVREEFTDFLNKKFWTILPYRLVRHLQNLRLSPLGVVPQRDRRPRLIVDLSFFGINQESVPIAPSDSMQFGRALHRILQRILQANPLHGPVYISKIDIADGFYRIQLAPYAVPHLAVLLPQHPNEEAMVAFPLVLPMGWVNSPPYFSAVTETGADLMNRRLKQRPQEPPHRLEELALFPPALEKPASSLPPTTHRVDDPIATPPSKPIHQPRFRRPMRYADVYVDDFISLVQGTENDRRQAMRTLLHVLDSVFRPRDSTRDLPFRQEPASVKKLKKGDASWSTKKVVLGWLLDSVDKTISLPPHRIERLQTILAGIGPTKKRISAKNWHRLLGELRSMVIGIPGARGLFSPLQEAFRTETPDHRLRLNAMVHQFLDDFRQLSTTLGDRPTRIAELIPQDPSVIGTTDASGTGMGGVAFLNTPSGLRPILWRHRYPKHVQSKLITFDNPRGSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS91</accession>
    <name>A0AAD2CS91_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000380">
        <property type="protein sequence ID" value="CAJ1934762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1098" mass="121451" checksum="49AE5DF51E348FE6" modified="2024-05-29" version="1">MSSSQMTTTEPSASLLSSTFDSEFLLEDEDWMDGPLHCQWGQSARRIAHECLQRSSAGEVSNHDSFSPINHLNDYVCNKTDLATGSLGTFAYLQYELSKHCTNEEHRLRLLTSARDFCHEVLNTESDIKAENDEECDNETPGSMSILTNTEIGAHLLLTVVYNEMDQVYRGRDHLRMLLRIWKQANGGCHLESNDNSKRNNLWYGRAGALQGIFFLRRELYSPTGARDLAIDIAKELLVQLSANSSIDGDDGMILGRIGILYTLLGMEEEEWNRLETEIPGCRQTVQGIIEANYIVSVITDGCDPSWATGVAGQILLLIRASQIFDKELYFDFAKHLTKRYLLPSCYNPKIGKIGLSDGIVGVAFALRYLQQESASERFVKLAMQNLSSNKGSVCGLFDGAGGLVLLLMDMADRIQPSSFPFLHPPSSCSMSLSLPTDNTDFDESGLLAVDNFSFHPKASLEIVQCCQNGTIEPEFQDSNTHLHSNADTQHDENEAKQHRFLESDHSRDCSPSRQKSEPRPNANSDSSNAIQSTDVSYSYDYSSPLRNSPSRTATVGTPPSTPARDSRIPTYSSPSSISVPSQHSNASPNPILKAALRPTRIPTPTKPNSVALQLSRQSRIRTPPRPTAKSNTVQVPAEKSSTKTQSKLRGQPFSNQDKGPRSPPRPNRLGTEYKVISEYQFRDRNGKFGRRIMSRCLDNSTAEGNLLNGGLGPCIYLRLQMSKASENNRTQLLKASLVEAEKALKVAKGRAGAVSQNMFNDEYIGAKCFYIILLHRLGRPNKALWHAEDLLELLRKGCESLPPEACGVLDGRAGVLKTIWFLRSELESPGFGHNLALHISKQIMYQGMLTAQKYKSESLVMWEWKSKPYLGSAHGVVGIIDALLGHSDEEMSILESMLPRVRDVILQAIESLDSCCDDSGNLRKKLNDEDDNDLTNMVHGSPGYCLLLAKASLAFPKKRKEFVLRATRLADSTLRPALQPGRINNANGGLMRGVSGIGYIFLALAQIDYENASKWISKAESIAHHAVDQLDSLISNSRRPYSLFEGIGGLASLLIDLLHPEAACFPFYDVSKRLEISSAVSTNGIQPFDPVPQSCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTK4</accession>
    <name>A0AAD2CTK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="87"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="279" mass="32876" checksum="6AED3362571C1E02" modified="2024-05-29" version="1">MKETSTSNDYSKRFKLDKLTSDVFGPENPPKDWADASLLVPHEALRMEMNCMIQSVDKLSELTKSNTMQSWQVVYFCEWYLDVFAPFCHEHHDVEEKIYFPWLQTRADIPKKELSKEHEEIVEILDELTSICKKIICKTGYDCKDEVEEMRTKTNVFVLNMREHMAEEERDIPPLAKKVFTEAEEKKILNKIIRRSKPTTTRKFSPSILISVSEWSTPEYYLEFRKEIPGPVLHVMEKYYRPDFETSIKPKRDAPFLQEEPILSRRKCFGLPFGPSCIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUC4</accession>
    <name>A0AAD2CUC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS9226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000073">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1945082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="538" mass="59022" checksum="9EE49B54A3665EBF" modified="2024-05-29" version="1">MASMGAPPGMGQVMVLNTKTQRQTGREAQLGNIRAAVAVANIIRTTLGPQSMLKMLLDPMGGIVMTNDGNCILREVDVSHPTAKSMIELSRAQEEEVGDGTTSVIVLSAQVLAQAEQFLLNKYHPTVIVQAYTKALAAGLKICEDLAIEVDVKSDNAMISKLVLSSIGTNFSSRWNDMLVDMAIQAVHTVTQTTPGGSPSVDIKRYAKVEKIPGGELEDARVIKGVMFQKDVTHSKMRRRIENPRILLLDSPLEYKKGESQTTMEITEEQDWNTMLKLEEEYVENMCIQIIEHKPDIVITEKGVSDLAQHFLQKANITAFRRLRKTDNNRVAKAVGATICSRTDEIQDSDIGTECGLFEMRKLGDDWFCFLEECKEPKACTIMLRGGSKDVLNEVERSLQDAMQVVRNVVYNPRLLPGGGATEMALAVALRKQGQLVEGIQQGPFMAVGDAMEVIPRTLAQNCGVSVIRTLTALRAKHAADPKCHIGINGITGELVDMNELGIWEPFAVKVQTIKTAIENACMILRIDDIVSGSKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUE9</accession>
    <name>A0AAD2CUE9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001591">
        <property type="protein sequence ID" value="CAJ1946110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUE9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068">
        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068:SF14">
        <property type="entry name" value="CELL WALL ADHESIN EAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042162123" description="VWFD domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="929"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1269" mass="131365" checksum="5B83D5A7CB2D1CAA" modified="2024-05-29" version="1">MKLNLNLVSVAALAAAFAPTAIEAQKGGKTVKANLGLCYAQAACVDFKVSKAADGSCAASGTCGIEVCMVLDTTTPGCPKDGSISHLCAASDGDGCAAYAPDGLTPLTGKGSSTDCLSTTFDGKCEPETQGSPTRIEMCQTAEPGQTVYWALKDSDVEDIGYYDYSASANYTYAADDGTDCYSPKIACFGNSTLSCADPKNDMHLSSRVWSYEIPANDGTSCDLCDNGGTVPAVEPSSPSEPAASPTSPTEPVATTNPDGTFVIPDTDTVDTDPGDADTVGADADDSGSSGGGKTAKANLGLCYAQASCIEFTVKKHDSTACALTGDCAIEVCMVLDTTMEGCAKEGPISHLCAASDGQGCAAYDTDGITPLTGKGGSDLCDLTGENGSAAFDGKCEPSEQQAKITMCQEAEPGQTVYWALKDSQVQDTGYYDYSASSNFTYPAEDGSGDCYSPKIACFGNTTLKCADPNGDMHLNTRVWSYEIPSNDGSSCDLCDAPSPSEPSSPSEPSSPTEPSSPTEPSSPNEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTVPSSPSSPTEPSSPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSTPTEPSSPTEPSSPTEPSTPTEPSSPTEPSSPTEPSSPTEPSSPTDPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPAEPSSPTEPSSPTEPSSPTDPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSQTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTEPSSPTDPSSPTEPSSPTEPSSPTEPSSPTEPSSPAEPSSPTEPSSPTEPSSPTEPSSPSEPTLPGSPTDIPPSEPTEPSSPTDPSSSSSGAFSPTAPIAPTGPAEPSSPTEPAATEPIGPTEPSSPTEPAATQPAGPTEPTLGAPTSPNTAPSPGSNGDPHFKTWRNEHFEYHGQCDLVLAKDDSFAHGRGLNVQIRTKLVRYWSYIKNAAIRIGDDILEVEGSSDNEREVSNYWINFEYQANKKKAATIGGFPLTIFDDLVPVHPKRRFEIDLSSKYPGQKIVIATFKEFVKVDFVNSSQEAFGNTIGMLGDYKTGKTLGRDGVTVLDDFHEFGNEWQVLPVDDMLFHSTEQPQFPRKCVLPEDPQGQRRRRLEEYSVTVEAAEKACSTLTDELSRKDCVYDIIATQDMDMVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUG0</accession>
    <name>A0AAD2CUG0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="272" mass="29017" checksum="FAEA26015975764F" modified="2024-05-29" version="1">MIETRRISTIRRHLASSSSEGPPTIPSCKIGDLLSDLPTPSLLLELSLAEKAVARRSDDDDDDDDEHDDDAALDQTLANDSNLDCLEGALFVHTQVVDTSTRDAINQQQGSGSSIVIGELDVPYSSLEKGAVLGIGLANHHVGGYYWARGMGIGASLPAHGIEVRSSSNESRSELYWLKRGPGLNAQETTEESSNSNDGKRSEWADFLVAGDTVQLVPKATSALLVPSSSSRAKGSFATLIGVRRIGRPLGADPIVEKVWIRSEAGGWVVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUH2</accession>
    <name>A0AAD2CUH2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentapeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUH2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044213">
        <property type="entry name" value="At2g44920-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47200">
        <property type="entry name" value="THYLAKOID LUMENAL 15 KDA PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47200:SF2">
        <property type="entry name" value="THYLAKOID LUMENAL 15 KDA PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20612" checksum="5F7743E4A295469E" modified="2024-05-29" version="1">MSATRVEMEQVEQQQQQQKQQQQQEQGSMLKTALASSLLAVVLAIAPNAGVAVSGGGLDFAGLDISGQDYADKNYKGKDFTQVIAKGTNFAKSNLQGCRFYKAYLVNADFSDADIRGVSMEDTSMDGASLKNAIAVGSYFGDSILEVKSLENADFTDAQFPVKALPQLCEREDMKGTNPVTGADTRESAMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVA8</accession>
    <name>A0AAD2CVA8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS10434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044665">
        <property type="entry name" value="E_coli_cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43246">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE CYP38, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041784016" description="Peptidyl-prolyl cis-trans isomerase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="92"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1946293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="268" mass="29172" checksum="B8506372515E2757" modified="2024-05-29" version="1">MKASILDFAILLSLFMSVSSFSSNSPITQQSRTPTRLFAEEPARSLKRRSILGNLRKAVVGSATLAAFRQKPAPVNAEDILASPGRTVQLEIANLEGVEGNTGIVKLKLQPEWAPRGVKRFEELTDQKFFDQCRIFRVLPGFVAQFGINGDPNVQSKWRSSSIPDDPVKVSNTRGTVVFATAGPNTRTSQIFVNTNDKGNGFLDKQGFSPFGQVVEGMDVVDKFYAGYGEGAPSGKGPNQGLIQAKGNTYLEASYPKLSYIKSAKFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVQ7</accession>
    <name>A0AAD2CVQ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="255" mass="28444" checksum="69EC3C0C1F1D56F3" modified="2024-05-29" version="1">MGTQRSDKTSGDGDSSWRDTLYVWDGIMVEVGWDLVKNKEETQKSDEIPLNWKGAWVPCENCADAKKAEAPKRVGGALDVESAHHFEVSGSAKPIVKDTKKVADAEDENKTSDDEENCSTAIPHQATFTGGDGWDMGEGSDTKKYKDEVHELLLSNIKWMGNMRDQRDNLVFAKGTNEFGPFISAGWMRPGCRLTLARRYLDESDARVKWTLDDLKNNVISGIFDKDSGDVCTPPWKCDALHSDVQQPGKRKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXS9</accession>
    <name>A0AAD2CXS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001346">
        <property type="protein sequence ID" value="CAJ1945306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXS9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="283" mass="32821" checksum="2FC681936AADBDF0" modified="2024-05-29" version="1" fragment="single">MDYNAIAPTLNAPTQTEAVARETEMAQNKILYSAKLDENMQRSAYFKRNKRTVKSNIMLKFVTKAMDIKLQGEADFTTTLENPIELLKRIERFMKKSADAEYDFLDFWEANQKIFAMKQGTTENLMHFKERFLRQAEVLQDLYDKFKDDIFEAVLATGFLCICDQTRTAPLMLDLQVTYCREVDYYPKTVSKAQDMLKIHMDVIKNPGVNLYQGKDQPNKGKGKGKPKDDKKEAACYVCGREDHMSPKCPDRLLPEIQWKNPKHYVDYRKKLNLNQIGATVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYG9</accession>
    <name>A0AAD2CYG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="132"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="324" mass="35857" checksum="65222B2051C53CB9" modified="2024-05-29" version="1">MNFEKYPWLVDLSSPEAVAAIEKAQQSFQQTGAAIFPNFLSGLALQECIQDARAQESTAFTTDDVHTAYLRPINENTDPLSVENLEMRTQVASIAYDELPPNSILGSVYEHPLLRKLVSKIVGKDTIYLSDDSLGCCSINVFRAGYHHSFHFDESEFSTTLMLQESEIPGTGLFQYTKPLRDSPDDLALTSVANAIHAYANDAVTTKSRLLLEASSAKEQTISDNNNNNDDDDDDKSNSSSFAPSLHTLDFAPGTLSIFAGSKSLHRVTRVKGKRSRLVAVFTFASQPGFQNTSTIQNMFWGRSSSRTRPRRGGQKEAEEKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D058</accession>
    <name>A0AAD2D058_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS9383</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D058"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1945239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="579" mass="65444" checksum="6A468C99D31BF863" modified="2024-05-29" version="1">MILGSLLQLTQISEAGRRCTSSSEWKLVGLVVWFRLVLLLAMAISCHFIPDHNPGGNVLRFDMRLLNNEEQQQQQQQPQQQGEEEEDCFCIKGHFCEHFGGNDESSSGNCAIASGNTFLPSPIWHFFLAPLTKWDAARFLNLALDPTMLDPKCSTTSGAVHCNFDASEEAHAFFPLFPAIVGQLAILAMNLVPLEFLPPTFEALLTLCGFLSNMTCAVVATLCLFQLTLSILPEEMKPEQQRHIAWTTCLINGVWNPASVFFVSNYSESLFSATTLLGHYLFQMENNLIGMGLGVVVWTIGSNVRSNGILQSLWLIVYALAKTCAYAITRNKKNSGLKYHHFYYYYHHHLVHAVFAIVAAVIIAQPMKWHDLQGFNRHCHGSLPSNQVPEWCALQQEGNESFSLYGFVQRKHWNVGFMKYYEWKQIPNFLLAAPILLLSVKGVYQWIHYSLVTDFGKGKLPLPRLILMDWPIQALAESVSTSIKTTNSNPLRPEEWLIHNPWLLGHYAILAIVTLVGAFIAHVQISTRMILSSSPASIWYLTFLIMQREEPKLQIAARTYPCLYILLGIILHVNFLPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDR5</accession>
    <name>A0AAD2FDR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000125">
        <property type="protein sequence ID" value="CAJ1931125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041981978" description="Plastid lipid-associated protein/fibrillin conserved domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1931125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26067" checksum="6E1923BF6D07C0D6" modified="2024-05-29" version="1">MNPKALLSFLLVTYPSVIIGLTTNFNSRSTTSLFAKKQQNRKSSSSKAPASKSVGGFGSAPKPASDGKVRTVSGFAGSGTKPLRVAANTFDKLRKDYGKEYTSDVYCKSPLNDPELLWFVGKVNIRPNTAATPDQAVIAQKRLILEYAKRELRPQNLGGKYASSLELWLAPGDSEMDAVQNKVSITKVDGSVADLSEDFSVNDVGYNPEIYVGDEVEKGGLRIKRDDDGNPIKPVFEVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEC7</accession>
    <name>A0AAD2FEC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS2781</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEC7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001224">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="66"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="425"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="461"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="498"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1932328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="63617" checksum="FBA2FA70D9EA7806" modified="2024-05-29" version="1">MGNTSSSKVTKKGDRKEEAKAIESSKPNNKITTTTTNTTKSTETLHSKLSVTDHTGDTTRNVFDYYEKVKVIGEGSTCKIFAVRRKRSSSFQEDEDDNDEDQQSLLALKEISKDQVDGTFLEELRNEVAILRTLDHPNIVKVYEMFESKRAIYLIMEYCYGGDLYGRVPYTEAQVAKIMTKLLSAVAYIHKKNIVHRDIKMENIMLESDKPDAKAKLIDFGLSQSYCISSSSSNNKSKMTHLSELVGTAYCMSPQVIRKQYTSKADLWACGVVAFILLSNKWPFEGSANKEITSKILKNDWNKDFEGEEWKHISSEAKAFVRHLMAYDEDKRWDAGQALRSKWLTKAFPSDEGPPEQKVLNSVTNALIQNANDGKMKKLAMQVIAYNSSTNDIEKLRHVFDQFDANHKGTINYWEFRTSLNQCKYKDADIKKIFKNLDVNGTGVINYTEFIAATLETLGKIEDERIRAAFDKLDEDNTGHISKENLCTVLGEKCTASDCDNLVNELMEEVDIDGDGTITYDEFLNLFRERHRQANQNACCSPMKSKEEEKSNGCGGKTCGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG46</accession>
    <name>A0AAD2FG46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000011">
        <property type="protein sequence ID" value="CAJ1927005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1927005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="166" mass="18238" checksum="EBF0144BD988E3E8" modified="2024-05-29" version="1">MARAIWSNLNKLREDGKSASNVPVVLLRKQPSVLCGTGLKLKAQDNFAPLNSNLNILGCVLIFGLISNKAPVPCVSAEGNKYVAVYAAACQWARGYALKKESEVSNSLKELFCDISFPRVLRPDDAQLLATGEFRRVANKAQVPIHPSEPYNPDQARRGIPKAFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH41</accession>
    <name>A0AAD2FH41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186:SF38">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1937892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="405" mass="44154" checksum="39CBDFEAEC2BEC0D" modified="2024-05-29" version="1">MNALSNTCFLKSPTDRGVNQDNSNSNSNNQAGASSSSTALRTLGRSDMHAIFSMCRKNQWNSVLSCVQTNPQIPVTSMIMDNHISTTILHQAITSKGNTEHRAKVIRTILDMAPQAASIKNGYGSLPLHVIAQRNTKMDAPTKELLITELVLAYKGALLQPGGVGKRTPLHIIFTDYISPRVTELMIQYGPQACFMRDKKGYLPAHVACSRHCSPEKLRMLLAVHPESLVAKTNDGQSLLALAIGTATKSHPNYALIDAIRTKLDGIGVGMSVPNGMAVSPRRRMAPVAIASTIKSNRPKQRCFRKTLTRRRATTSTSFWSNSASLDVASLAAPSTSVATISNDCLEDFHLSNRESKTRKVTDESTDESTTASDDCKQPALEEDPVSLLLHFSRHTDGKTRVEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIB3</accession>
    <name>A0AAD2FIB3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FIST C-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000321">
        <property type="protein sequence ID" value="CAJ1933979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIB3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14939">
        <property type="entry name" value="F-BOX ONLY PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14939:SF5">
        <property type="entry name" value="F-BOX ONLY PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIST C-domain" evidence="1">
        <location>
            <begin position="411"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="555" mass="60877" checksum="CF35AE391F217487" modified="2024-05-29" version="1">MEDFNSDLVLHMVQFLNAMDSGRLAASAKRYYYLVHQYRSLSGPQLVTSSSWDPSTKEQIGSKEVVQQGIEGLQKEPNLILAFNSPRSALGDELPRRFHCSPDTTILGAIAGDIQVNQSSNVEHKSNASAMFASFPNAEVVPFAINHGSQMEEDIQSMKQKIQQQTDERWWKAMIVYACGHGSSFAEYFVSTMQQSLPNAAIVGGICASGYVSKSTGSKTKDELSKMTTRQLKNLNRSLGGDVNQPFVEKSELVDHVYQLCQTQQQSSQAPSLTYCEDTVFGVLLGGDAPVKSMVSRGVESVLQGPAQPTSPFVVETVELARPGDDAYLFRGDDLKPMHMIHRIRNTEIGQVLTAAEMINQVAQTADFIGLKRPGSDGFELHIMTPYCQMAQQFLIMTNGSQEDIKTMQDAEIDFFKLTGEACLADMDITVSKLKEQTTGERILGAVMYSCNGRGPQRGGLIAEAMADATRFSNIFPNVPCLGFYAGGEIGPLALAGNEKVFQTGRVAVQGFTAVFALFIVPDVEPPESYHLDDSDVNVWQFVQSHLDKSSTSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIZ5</accession>
    <name>A0AAD2FIZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000424">
        <property type="protein sequence ID" value="CAJ1934953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="221" mass="24644" checksum="1C44D3E9CB38F74C" modified="2024-05-29" version="1">MAPVAPTNTPTRAPVVQVTEAPVVAPTQTPVVMVPTEELLSLSTVKSTRNTFNKRMVYQGSISDIRMYGKPRRIVHRPGAFGGLPVVDHAFSRPPVGTRSPTIEPTKAPTPYPTPRVFHKVCRDGRVVEIDGTHSPTVLPSMAPTYSPVVQQQTRPPAFVGYVWGNGYGHGNDDDNPRWSFTKNEGKLLFDHPNLEKAIYRGDFSQVRRQFKRRVDTMSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ24</accession>
    <name>A0AAD2FJ24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000416">
        <property type="protein sequence ID" value="CAJ1934924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="381"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="935" mass="105305" checksum="43BCE1656135CBFF" modified="2024-05-29" version="1">MDCPSDDQVDVALLPPPGGAVPQNDDQDDSSDGDDQDDSFASSDDGQADSSEDSNAADDSEDDEDSEDDDEAESGDDDDKDDDDAEEQNENETALLVTDLEDAAAHNPNESTQLLQAPLTSLRNDKDTDKNNTKATVTARMQRAINRAAAIERMNNRFNQTGRYVEALEEFPLPPEEIGAQDPEEAGATEVEPSAETGAQLEVEPSKETGARHLEEEVTFDPPEQQPLFHDDMEEQIENDSLDNSDSSSIVYERGDVALAHMAKERQLLCSVPRRIGRFALAKFLENAYRDDRKYWWRYVPEKLQNTADVHRCMHLLLGNQTFNVLLNQMTAKSGIKKHGELAIAALVKELSHNLHIKDVIEGKMFNELTQEQRAKALRAIALTKEKRDGQLKGRVVADGRPQREWTDPDSVYSPTVSCEGMILSLGIDAHEKRFVSVCDIDGAYLHAFMDKFVLMVFEGDLADMLVRACPMYAKYLHVTKTGKKLLYVRLKRALYGCIKSAMLWWLMLSEFLIEDGFELNPYDSCVANKTLSCGTQIAICWYVDDLKILSKNEQAVHDIIKKLEDRFGAMRKSFGKKHTYLGMEVEFCDDGSVRLSVPDHIKECIKDFGEDLGRSAANPASKKVFHVDPDAERLPEPKRKLLHSLVQKLLWVTKRCRPDIMVPIAFLTGRVQKASVEDWGKLRRVLSYLDSTIDMPLTIKIDDLTIVKTWVDVAFAVHEDFKSHTGNMISMGKGALYARSMKQKLNTTSTTESETVGASDCLGQTIWTMNFLEHQGIRTRRRYYYQDDESAMRLEKNGRQSASKRSRHIDIRFFFIKDRIKRGDIHLLYCPTEDMLADFFSKPQQGSLYKRFRDMVMGITPVPPVEDPSFTCPTSQERVGSSIFGAGGRRTDGEIMTKMARPTVTWADRVRGFAGGIARPESLGPAHKNKKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJA3</accession>
    <name>A0AAD2FJA3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJA3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="370" mass="40045" checksum="95F9426BE2755A12" modified="2024-05-29" version="1">MGFFQNKMSRNGNVRDALAKLRTRHNAIIERRKTEREAAKADKASTLASSSSPSSSPAGSVIGRNSLAELDSVCPRQSNNSSVAELDSVCPKSPSKTKSATKTASKSTKSKSSTTNNNTTNNKIPSVAEWLLWGDDESVKVPQTPQPNHTTRRVNTKPTNISANLPLQRGSSASPVASKRSPQVERMIPAISESHSFDNSQLDSHFYSEFTDDYTVDDSLADVTLASSKEPGLFAHGLMAVGELFTGAPSTPAATPSPQRRRKSSRSPRRIDEGDDESDVDEESTQAYSTYAKDDSCLTGKYARDDQSATTATTASSSPSAGFDAVPPTSRWNGRRNAPVKYHNMTNVNIIESFGMEVEMSLETVTRIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJS0</accession>
    <name>A0AAD2FJS0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001426">
        <property type="protein sequence ID" value="CAJ1945447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="85" mass="9536" checksum="DF27304AD73D5CD0" modified="2024-05-29" version="1" fragment="single">MSERHSKNSKKSNAERQREVDRQLELMKAAIGDDNFDSDSESDSDDSLEQLKERSGSSSRNAVESARKFLWDEADDEDDAVLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKB9</accession>
    <name>A0AAD2FKB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS10234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001580">
        <property type="protein sequence ID" value="CAJ1946093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKB9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1946093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="220" mass="24984" checksum="924079E77178723A" modified="2024-05-29" version="1">MMLSKRVLHTSFGLAKSQIVKSNGPALLIGLRSFATTPRSAKTGDPNVEDDNILPTPWETIFDRASQIFFISEIARAMTMALEIGLKPKVTINYPFEHGYLSPRFRGEHALRRYPTGDERCISCKLCEAICPAQAITIEAETREDGARRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFATETHEELLYDKEKLLSNGDKWEKQIAKNLMNEFLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNI5</accession>
    <name>A0AAD2FNI5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042085357" evidence="1">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="200" mass="21276" checksum="3E9EB29902DB2E68" modified="2024-05-29" version="1">MKKSTLISLLATSLCCSEGNALVDIALPTAASLIASQSHAAFSPATTFAQSTIATSSISMADSLSLPQMAGPDSFTDVAHFALDFSGLLSNPSRLMMRLSALGSSSLDIAETIPLTTEPPSSPLVEAEVLTDMAHVALDFSGLLSPSKSMMRLYSIIGRLFALSADYLPDHTVHPEELMIQLFLICVTMRELIQEKPIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNL4</accession>
    <name>A0AAD2FNL4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001721">
        <property type="protein sequence ID" value="CAJ1946981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1241" mass="136412" checksum="50CF0167225AD91C" modified="2024-05-29" version="1">MRSPQARPYGNGGRKPSKYEDDTGYSAHESGRRTHYSEYEKSTTNGKRTVFSEYTTDADYTDEDGSSYSESDNGKRTPFSEYITEYTDETDDDRMSGTLGIARNQYCTTLNALVEGSDSCSSESSYSQSTFASDFDRMCNANVNTNCMATLFNRNAEVPGTIHCGGEHSDAQQKVSLPLPLHYMDHLVPSKQEFSSALDNFAQKFDTGDEERPGFPQVYKSLFEANLSQTASVEDDERMAENVPRRKGTERNRSQDLAFPKTKRDVLPKVEKDKDPDILSPPSHIIINDDFTAVSSAESFGFAPETQKTSSGVKHKNDRREGNNRHSSPRHSSPRHTAPHRPSPRHVTPHHPSPHHSSPERPSLRCTTEKNKYEYSSTKVDAPTTTRHGLDRLMRKQTASPSKRREEIDEEEAPVFKGVASMKLPLSGGKVSSNGKPNVFSFRHVDESRQDAHTPEHRIASARGEGATSRVNTQPDKRDSAGLINKESLSYNELVPINTSIAKAKANRTKNHLMMNSKAPSQSYPPRNKTSIMRDERNGAPGANDTNAHLWRNSANSIPHVLSLKQTQTGFSELTGEPDAFGETKIDSTPLETIVTSPQGHGAVNVQVLSLKPTQTAVSELTGEAGDFGEMRGYTVPLDTIVSSPRGNETPPTKKQPREECTRSPLATSEIRVQTPSRRNRDLTNDMGVMKSNNAAPKESAYPEPSLDGYVVARRATPNKKAETLDKLEDALMGSRKSASSDYMAKRQGSNETRVFAFDESKSCARPTMSDSAAAADIGQAEHQSTTITAEGQEAKKPSNDIKSKPTQVELDDSTPSRLGEPIEVTKAALESTEEKHPEKREFEKASGREKDDRDVRAHATKEEGADTAQSLYPSSFSDYCKDLSSNDDKTSGDQDGVNGDSAVHKLEGGGPASLSALDNEISLLQSQITGLEQQDQMSEIYNDQMTSASHHFEPPIIESEDPVMPIIGTTKIDDDIPRLQSSLDPPRASSGPPESGRMTSGDHHHFKPPLAPTEQGPTSKGKKQKNSSGFKPASKQNKSTDATLVTAPTVMSIDTPFTVDGPLVLSPTVKGPEEIKWNRNSSMLVATAIALPFERSSSHGVEIDASFFFIFVIGTRKYISDVLFIIVAWLRHLSSLGFAPREQARFRVGLMVPPITEDDVLREHQLQSKSTVTSRLLSPASEEPGIVVESFVPEMWAENESAGGKRGAFLPPLTSTNSIWNRIFRKQEVVTAATRWGSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPJ9</accession>
    <name>A0AAD2FPJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="271"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="593" mass="64257" checksum="711D5FB6B0A7E881" modified="2024-05-29" version="1">MTTTGSVLSPEMKLMSKPGPTSSSSNATPEVVQQVPAIMTTQPAGNPAILNRRSSWSDPPRQLRQENTATTATTTTTTTTTNSNHSATTATTTKTQIKPVVSADASIIDSALLAALRDPRERIGLLRLEQTLCDFVTKQPQDPFVDVGGPYNSIVKSPTIGYISPGAIHTNTNKSQTSFQRCILHRLADRFEITRENNMDGTIRLLKQPQTKVPSRLLLDVKSDEYSLVQSMDQVSLNAGTTVNGKPTFASAVSGNSTKSKTSSSRRNSSDVSALKSKNGSSSEKGSTSGGGAKKNKMKIMKRANSCPVSGGAMNRTNSNTSLKKKNSSLTDREKAYAEARARIFQQEQEEQQQQQAAANANSNAATNAGASSKDALPPSSSGIAPNASAAPFEPSTATTTISSAATASNVTASSNTTTTTTATNSKATFRDRNQDVIDPDFRRGNAVASVMDYDQQQQQQQHYTNPTNDYYGYYNAPQHYPRNQYAQHQQQPVLQQQQQQQQLHAWVPSGAKDKAQHLQHVQQQQGYHHYHQYPASSAYPKQQQQPQQPQVQYHHHHQQQLFSYIPSPPPTAKTTATTSTATTIASSDKVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQI1</accession>
    <name>A0AAD2FQI1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protochlorophyllide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1949624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31214" checksum="616F20876965A0C4" modified="2024-05-29" version="1">MSNNVEYSIPDQVARFSKAKADGNQRYLDITTVYDGSSLKDKNVVVTGGNRGLGWEIVQELVRQEAKVVVLCRSTNDELEALIGKSYVISGVDVTDTKAVQDACSERMPNIKFDIVINNAGYFYEPCEKILDNSLNFAEQLKQINICGLGPLRVNSAMVQNDKLNDNAKLVIITSQAGSCEWRSTQNKDAGGDYGHHMSRAACNMAGVLQAEELRSKGYSVILLHPGFNRTEMTAKYKESWDKEGAVEPAMGAKRVLFEAMKSNIETTGHYVNCEDGKQIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSB0</accession>
    <name>A0AAD2FSB0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13022</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042440667" evidence="2">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1951338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="76" mass="7978" checksum="592090DD8699B0EA" modified="2024-05-29" version="1">MFKLSFLLVALISVIASVTADKPKALRRLQTAAPVAVPVAVVTAPIAVPVAAASKSSKSSKSSKRQLVHYNTPYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTM0</accession>
    <name>A0AAD2FTM0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="843" mass="92967" checksum="9BBAE88622055242" modified="2024-05-29" version="1">MTMDFEFDDSVDSSRASSRSSTLVSQRSHKRRRQQESDDDSSTVSSRRIAVKGAGKSASAVQDAGSFQMLRDECLDLCSTIISREDKGDGKSLNAAVDLALLLSNKKTRSILWQNDTLQDLGDIDSNCGDNSSVLMSILNAVASHTPKKSRGARNSTNPSRNRSRTKSARRKQKQQSQNDSVTSVGNQKVIPTSPQMKQVLACIFYFLSWDCTLSKDHSVAAMGTKTNPNIARKIRMSILQNGDALQGAVQLLFGKEALSTANSIPSLSVASSSMQTPKPNSQQRVVAISGICSPASNASTISSVSFQEEAQQLVPIESKRKLGDPTAAGRQKRRKRRLMQSIAEDETVSNPNEDMSSKKILPPPKLNCSSTDFSFSDERDTFATPKAPPKVSHRGPKSCDEHHTTTSGAATANPKLWKLLSKIKFTSKFIPDHLQQDKWLSMLFLQSLNRVIEGKDLEGPSCMENENDDDNNEASSDDESNEEFNPILLTNSLLYKSGVLPLLARAMSDSFQEVTRMLIEDDTFASTMDWDYRQEQMSVLASLIDGACLFCESNRRAFCEEDPFSFEERNQGLLCHIFLFLDQCAKRCCKTPNDKMDAVMLMGLRMLTSLTHDNEVAGEQLTSWSGQGATGDGSIRGLDTLANLVFVLEGSGDETKKESSLTSQEAYHHRYDCIVFCLNTLANIVEGSDVRRLLTEINVDAPSCRILWLEWLCRWLKIQTASFQDAIMDGGTNNGQSSSQERELQKAEEDRLVAAGNGCVLLACLMKEPESISEEPELTNTIRQLIVDQMPKSKDGGSTGVIMIVNTLKAFCNFYQLSLGDLSVAIVAPVKKLIQELQEMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU53</accession>
    <name>A0AAD2FU53_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS14012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU53"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028307">
        <property type="entry name" value="Lin-54_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446:SF34">
        <property type="entry name" value="PROTEIN LIN-54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446">
        <property type="entry name" value="TESMIN/TSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRC" evidence="5">
        <location>
            <begin position="245"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1953402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="698" mass="74084" checksum="5C2DA9E0E1B990B5" modified="2024-05-29" version="1">MTLPKTTESNSQKGSASGQAQYAKLPKNLAPPPPPTITNVAPGAMGGPTGPPPPRHAAHRFYTFPGAVPFDPTDRGAPGPYTAAQYEKARAGMGLPHYAQPPPPPGARGVQASNSGSPKSQLNRGRDQAPPRPHYPPPMHGPPDRHSVAQPHSGSYPQMEHRPPHWPSGGARFPPPTFAQPYPHPPGADHVHHAQPGPYRYSDSSLRREAVSRLTSADRYNVQLDDREGATSPSQIETSHREEVTTMGCTCKKTKCLKLYCQCFAVKIYCGSNCRCLGCCNTQAYEKDRKEAIRNILARNPTAFDTKFKKTSDGQIIIDKAVPAPAPLDRSLAHKLGCKCRKSACVKKYCECYAGGVKCSANCRCSGCKNMPIGGFGNGPPSMTGTPILPSTATTQPAQGGKTNGSPRPGWMMNAAQNLAFLKHASPAAQKAKRMSIESVDMGSMPSLASEGSSSPSAEAHGNGSTKTKTNAGAGISASIPANATSGANTNQAGDRGKATAATATKGAQKKIEEATSSEKTAVSALLMAAVAMTEMVSTDDGETATPPAKTTSSREPMEVDFETPQKNLLDKFNSPKRKVGDREVPKMPAETGSMSEAQSSSGDDDSPKRDFEGNNTPHSNQQKVKRSRIGSHKKFSKTLGNDLDPKQVASDVIASTDFSTPNTKGQFKTADLTPVSARCIDFRNMHVNETTTAKAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV18</accession>
    <name>A0AAD2FV18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001855">
        <property type="protein sequence ID" value="CAJ1954068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV18"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="272" mass="28431" checksum="D69B8160329024ED" modified="2024-05-29" version="1">MQIPTQGGGTVTVPYSMNANGEIAFSGMQLGHQGFSGAQRKGEPKDGKKKAACYVCGNEDHMSPKCPDRLLPKIQWKNQDQYVDYGKKLNLNQIGATVPDTVPAIVPGASASTSGASSVAGSIPTQGGGTVTVPYSMNANGEIAFSGMQLGHQGFSGAQRKGEPKDGKKKAACYVCGNEDHMSPKCPDRLLPKIQWKNQDQYVDYGKKLNLNQIGATVPDTVPAIVPGASASTSGASSVAGSVNTPLRLAGTTGNQMMQVPSCRFQLKVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWG2</accession>
    <name>A0AAD2FWG2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWG2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="638"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="731" mass="82854" checksum="D7A5863EBE1B6186" modified="2024-05-29" version="1">MGKDPTQHGQASQGWQFWSIGGDDSEQPASHEVKKAPTYQVVNDKKPVKPARHDAPTKLLKSSTNDTNSTIIMKRDGWQFWALGEQPTNDEQTSISVSAPIHKASSSQVIVTSGPKKGWKFWAIGVTDSPNSMNPNDLIPSDNFNNTDQASVALNAKDPVDSRAECAWRYWSQMHHQEELIASPSDFDCQEAWQFWAIGVSDASSQVSLLTEAFEMDPPMVKVVKIRTLQPIEPRNESGWRYWSSMKKDAAILKSKEINTKQGWRFWAIGEANRAAMMDQKQLIASEHFAVEPPIMKPVAPKMSLSQDESGWRYWSRVQQTEDVTKATATNAVSKKQGWQFWAIGSTNHQSSSARKKHQLSSGLQKDSWVIKTKERNEKEARGESDWQYWSKLLTEDAALTSANVGKKQGWQFWALGSSNQASAYRKTVVSEGRDVEFPAIMNSRNTTMDPIEQGGWRYWSRVNEDSHEDLQRDDIMPLSHFPLYSQGATTAATFSANPKFYTIQKKLERIDEEKGSKDTLSCDEDLKIEDSETSQARQPLHADGDNANDSIPLSSVTAAEATKLTTIQETKTITMKKKASNAIQNFKKSLPTFEKQKEKLLSMDSKLRPNKKKHTHSEPPIIPKRGILPKDWVHKSQTRTRNNLASIKEKQERYKQEASLLFAQAEQRKQEERRLNEDMSDWIFEDAVLRGIAATVTNAVDAMEYVVSTFRQTKSTMKEEEEAIQFSNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXD9</accession>
    <name>A0AAD2FXD9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXD9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="173" mass="19838" checksum="B9704642F7ABE988" modified="2024-05-29" version="1">MRQDYLDTCKSSHTSLHVLDWSLDMQQEPPFQIKNQQEWELGEIDVAAQSPKRITPWPRRHRVISRDNGTEEPQNDEGSFDDIKPNSLTCCFETTIDGTLSELPILSLEPSFEGTSSRPKRSRDESCDDYAGEEAQLCGERQRPLSRKRRRVGSRNNALCAQDYDDIFSQLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXH7</accession>
    <name>A0AAD2FXH7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1955904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXH7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="217" mass="24198" checksum="6D2336E31BA481A7" modified="2024-05-29" version="1">MSLQTVINQNQQTIAFLEAREYDNAIVSSSSALECLGSIPMMMPQQDDDDLLHQISSSSSPEFSFDQCMLLTSIPEGDDQCGTHAFMYNHAIPLPSNVTDRGIITPILIFNAALAHHLVAMRKDERSPQYLDRAMQLYTLVYHSQDIVQNPLFHFVIYNNAALIDLQIGNKDTWKACLGHLVHIYMILVDESCISELRHIQGFLGSLMATMPVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G049</accession>
    <name>A0AAD2G049_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G049"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="102" mass="11461" checksum="816A533FEC62984E" modified="2024-05-29" version="1">MFAVRPITTSFQRAIMNGRPASARFMATIVDGVDFDTVAREWRCKWSSDDDKKSLAEAQKALNEILSEVKGVDGFKKIDRVVCGGCLDFKVITKFLEEARIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0I0</accession>
    <name>A0AAD2G0I0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0I0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="79" mass="8536" checksum="34FA1615A2F61131" modified="2024-05-29" version="1">MGVFAKLKQKSAVAEGLAGSVRDNPNPQWQPPPKQHVELGTIDYVNLTADGKHGDFDAAINIARLTGKTIFANFVEWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1K8</accession>
    <name>A0AAD2G1K8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002016">
        <property type="protein sequence ID" value="CAJ1959753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1K8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="360" mass="39805" checksum="4AD7A7BDA37AC3BC" modified="2024-05-29" version="1">MALTFFSQQEWDKILSPVLRAAVPKAGICRNFPRAMVYAPIALQGVGVPHPYGLQVIKHLDMLLRHPANQTKTGAFLEAWTLSAPQSLSSLAVPRSTRAGSSSTLRVLTYQPKPSSILDLWHHFGSLAESGSHGWVPEVITIEGSADRLVQALLASTLGAVSNGSYKAKVGTACAQILTEDRRDIIWITCQTPGKFEDQSSTRSELIGLMASLLVLDWMSQAAQLKRFASQPSVEMACDGLIALDKSFSEVHLSSSGAQFDLVSTIRTVLRHLPLQVHRRHVKGHLDKHRPFFQLDWWEQRNVEEDSKAQAYHRLLESTGRSAASNPRFFHELVSLFIDGVKSSKLDQAHIMELVSLPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G288</accession>
    <name>A0AAD2G288_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002043">
        <property type="protein sequence ID" value="CAJ1960054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G288"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="93" mass="10579" checksum="EB53FCC5208DABE2" modified="2024-05-29" version="1">MYEQDHDTSRGNDEIDDQLTKLIDELQQMKNSKDEIQRVLESDNEDENKSEGERQDSDKESIPSSHGHDSDDEDNDKGGDDTPTLQATQTRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2H0</accession>
    <name>A0AAD2G2H0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2H0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="71" mass="7918" checksum="A9B19185FFDB0D43" modified="2024-05-29" version="1">MNPERSTSQRGQTSASSRPTSIHDFGTNPDSGVPSTIVETSAKQKRFDLTFMHQKVFLAFPDDFDLKDLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2Q1</accession>
    <name>A0AAD2G2Q1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2Q1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="126" mass="14003" checksum="3E53FA854F6F04AA" modified="2024-05-29" version="1">MSPNMNNSFKDASATASPSNYLSPSDSLIDILLEASRPHDTLPAPPAEEDELVVPRMMIPLLPMSNQRMTERTQNLQDTLTTVIGILEDTSSFHPRHRCAVVSRRSALLRNYKKERGSKGGPTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3G8</accession>
    <name>A0AAD2G3G8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS19202</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3G8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="88"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1961449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="279" mass="31835" checksum="360B4F9F2AFA1145" modified="2024-05-29" version="1">MHLNNSNKKRNRRPRSDSQGSTSSTSSASSLSDGEQGHSYHRAPQSKGNLNQQEKNNVNNKCRRSKGKRRSRSHKREKNQLSLPEEAKFVALDCEMVGIGEDGHTSSVARVTVVDWDGNSLLDEYIQQAEPVTDYRTFVSGIIAQDLDDATLSLEDCRDMVLQLLQNHILVGHALKNDLKALGISHPWWLTRDTAKFEPFMKVRFDDGVLWPRKLKELVSEKLHQEIQIEGKPHSPYEDALAALDLYRSVRTKWESAMTYKIDKTNQIRLQHHQPVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3K5</accession>
    <name>A0AAD2G3K5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS19262</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3K5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="180"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1961569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="362" mass="40726" checksum="E9F672C3C5DA3506" modified="2024-05-29" version="1">MSFTQAEVAPLVGGRRESNVPRRRVPQHVPTFEQSMYSVDASEKMDRRSLCSRLCTQAKHDCCVGKAGELDINYYEDTYNDEPWGCTCGTSESNGIWTNHGDKVGTIMSSMVWILYMFAILTMSLLAKNNSIRPGIAMTFITLATLALASHGKTMLTDPGSIPQEAVPLPILFTKGVTTHAMCSHCQTYKPPGAHHCRICNRCISGMDHHCPWMNNCVGANNFKHFILFLCYTWTGCAYALIVFGINYFFCNSDECVFPDLVVLLVRVMTILCIMTMLFVSSMLLNVIYGIMTGIGTIDRLKKKASGTLYDAEDEPMPLKDVFGLQGYWTWFLPVDPVFEDYDRVMGYAIPDRLKRERDINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3S6</accession>
    <name>A0AAD2G3S6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3S6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="178"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="388" mass="42132" checksum="C6EC5ADF7DFF64CF" modified="2024-05-29" version="1">MNVSNSSSNSRDLKQGRRHQSLVEPQPIASCVSQGAEVLDSSSSSSSQPTEDDAIIAAPEPTNDRANQQESPAEIPVGNGENEQDNDEEEDQDDDDASEYSYEDDEDAAFSGFLSAPAAASHSSAAPANSASSSSANIVEEDTVVPNVAAAADAKKKWKEPTREAVSMSLRAQKETSGSKRRLAQDLYRIMNQDTKDAGFSLAPQSEDAMDKWTIKLFQFDKDSNLAKDMLVLGQNHVELEMKFPDQYPFAPPFVRVVKPRFKKQTGFVMNGALCMELLTNDGWNPINDIESVIVSVRSLLVVGDGRLQAASELSKKRYEALLEAASGESSSDAKRQKLATGEHSAKPVAKATIGAYTSSEAQAAYSHLSDYHKKKGWDSSGWWARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G532</accession>
    <name>A0AAD2G532_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002109">
        <property type="protein sequence ID" value="CAJ1962520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G532"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="160" mass="18925" checksum="A6E20044D5BE3A51" modified="2024-05-29" version="1">MEKELMRHFDWKMVIGLRYEWVNIPYKGRSKWNKRSSGCMMWHVYVRSRDAKRADRELRLWLHPSTPKKDFPWCAVTHYISDWKAAQNGTISVTGLVPFFTHHLGELTTTQANRVIAKWLSISLIHTTRRKELVWCLETLRARPSDQTLQGIDKAITFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G535</accession>
    <name>A0AAD2G535_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G535"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1963287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="401" mass="45643" checksum="64B09C9C0A70A038" modified="2024-05-29" version="1">MPRSSDIVVPTKGNMKSNDRAPPRRHTYAASDKNVLDDLFAFSMHATTEFYDDVLASPTPNDMYTDDFYDDDTAHYSAIGSLPLLSLDEDQEVDANSATTSSSSSRRKSLSRSKSKKLKKRKSSKRLSSDSISSKKSTSSEGKSKTKSSKSKKSSKTPETKSVAAMLKKLEEYEETLKEERRLLQKERDEIASERETLKLKSCELESRLDELEDNGGMMSPRSRHDINDDAIRIENRILQRRLQRQDEIILQLSNLEGGSQAVVEQEKNSDEILRLEKELSQAKDLISKNEKIIKGQKLTIDRMNKESFSKSYSMIFPTKKKDDDTVATLPFEDSFSSLDDSSSSLRFSSDKKETRKSSSSKNDRIKNLIKLQRHNSSRERFRNRIMTPEEAALSHLLDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5B4</accession>
    <name>A0AAD2G5B4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS20242</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002151">
        <property type="protein sequence ID" value="CAJ1963605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5B4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1963605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="238" mass="26291" checksum="806B505E5221A21D" modified="2024-05-29" version="1">MESHLSPLHNNAIVCLFMILSFKLCIELACWTRLRLNRGISRPLLHILLSSGVIFWPYFDESDWSWRLNALVPAVVGVRMIYKGGIVRDPVDADVANMSLSNSPGDLLFGASFLPLVMCYLGIYQFLKPECAIVPAAFLGDSLAPLIGSRYGRHLFQMPFGQSKTMEGSIVGVFLGTIMGCYFYSYMMGMQLLPLRMILAYSAIAAVAEATSPANMDNLAVPIVLLFSAEWVQLLIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G766</accession>
    <name>A0AAD2G766_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G766"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="143"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="463" mass="51210" checksum="950A0976D759D8E8" modified="2024-05-29" version="1">MQAASRQVTKQTVSSVQSRYQVACRVQMLGSFFWDNPDVLMGKLKKAESKLMEYAKTFGDRASDDNSLQMTTHDTPIPSKALPFNRENVLTNDLSIHSLRVTTTTTTEDENANANADADANADANANANAHNISSISKKHPTPLVILHGYMNGALYFYRNVVGLSNYFQTVYSLDTPGCGLSSRNPGLLSHVDKTVEATEAFFVESLEAWRKANDVDKMILAGHSMGGYISIAYCEKYPERVEQLVLLSPVGVPKEDEEKTKAFVNRMSWTRRSVVNSVRYLFEFGVTPAGFSRRLPSARSRSMIESYVQGRLPVITDPLEQQSVIDYLYYLAMVPGFGEDMLSRILTSTANARKPTVDRIPKLGVKKVSFLYGDRDWMDIQGGISVYEQCKLQGNENGPDIEVYQLQDAGHLLMVDNWRGMNAGVVAMCGGISTLSPHYPMPLLVRSTLVSSPSLSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G772</accession>
    <name>A0AAD2G772_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G772"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="379" mass="42030" checksum="422AE3C2D3B1AF4E" modified="2024-05-29" version="1">MSSAAAASSRNRNHHRSGRSNANTPDVSKGLLVSRRVPTPQRSTKNSNSNSSSNSSSSRSRSNGSNSKNSKKHKKGSRKQLPARQKSFRQRMSDSMQQWKSVPSLKVDMDDEKSHASRQSSSSSSKANNKKQRIIDIHQEAIKGSNNSKAGFRRFLSRGSSSRTDDTFESLATISDRLNPGPPPPLSACFPPSLRTERYLIRRPVAKGEMATIENQHGTIVAVVEETHYGRRLLKTADGKVCAMILQHQEKYGPITYSICGSSPIVYKQSIKFDQVGLGYYKWADVQNAGGMGGTISLKHVKDEIIPKDHTFCTKMFGSVFRLKKTRGHVVLDEDKKECAKLIALPNTGRAVQIAPKHDVAMMLCYSVIVDEILENRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7K6</accession>
    <name>A0AAD2G7K6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7K6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="334" mass="37274" checksum="52A1BCCDB974A9D8" modified="2024-05-29" version="1">MDTSTTVAATAAAVIVLVSWVASSLYLFSCDKRKQAMTDNENKSFVYSWTFHVESLRFYGMLFFLIVLAAGAIVTEKSGIDTIEDPTETVIFELFGFNHSCNWIDHNPVKMIAAMLFVPLVQIPFMLYTVFWHCRLAKSAKTGKVPKWLLNVSRILSPYNFIAMSQLHLWFVNNPTDTYGFTAHYIPYLVFQIAISFFKLLNLLYLIYEEKLPWGVPASVASAYVAFYTVVVIVSAIFVSTTIAGNPIIDATRSSGEKLFTNILSYVWVILGIFGTLILSAKERLDGDNITLTIGDGILRVGSSSDEEEDMTTKKGEAVIAEQPSETAQEVDHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7M5</accession>
    <name>A0AAD2G7M5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PRKR-like endoplasmic reticulum kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CYCCA115_LOCUS21224</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002210">
        <property type="protein sequence ID" value="CAJ1965632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7M5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="13" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="743"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="292"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="884"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="888"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAJ1965632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1234" mass="135688" checksum="90EB0ACDA42C5737" modified="2024-05-29" version="1">MTFTALQRRRTRGTVLLTALWTMLSIVILTTHAKKGRCLSVAEAKSIDIAADGSIATTSSMPWQRGGAQAQPQPYMVVATVDGSVMVLDAQTGTSVQIFGSGMPLVSPSSHLPSGRRIVPGLDGRLYVTALPQQQQQQQASSNNHNNDGMPGDNGGPPSEDSGGGTTAGNVLQPLGITVMDVLHNPVKTCNANNPQQEECGIVTATKSTSLFAIDSASGNLVWHQSPNGETIQHDPPSDQDRHNREEHPQQAKFTVLLQREDIMVQQISTDSGLSVWNVTLGSFQGLEFGCNSRKERRGGGHGDDMFLPGGRKPLDTNSNFLLDSSLSSTPNRHPDDDEENNDHLPSVVFGSDGMTLTAVDPVHGTSLWNREFTTVVASVFGLNGKSWRPLTVLEGTSEDPSSTSSPGSQSAALPEGATGMTLYRPPSMEEIFVQNEGYLEHLDFLYKLAEEQPYNLKQQQEQNRLLSPFPAIPDDLQSRRHAMNKLLGWEVDDETISATTPRPDQLALPSPDDYTLPQYDIRSEGVFLQWPVILALLCSAAVVFQKWYEHQKKQWYQDFEANAELTVTATSTDVTHGILEPEKPGGNPMRFLMHKERTINLRQQLSMPGEDQPPPGPPQVHNVSMTWVQPLSPNGVGPNGQPAVPEAAAPIVPAAGVELQPVAPAQSQQVQERWEKEALGLSFNAKTFWMAFQQRLQRTLREVKSLALLDHPNIVRYYTAWLELGNNSDDTGTDGGAGVSDYYLFSGSNAGATTEAKTLTNRVTSWRRPSMEQVRRMADYNPLGGWKMEDEEISFGHNIPGVPKSLEDYGFTFDRSDEEVHENNDAENSEWLDEDKDQTEGTNHNALVQYPMSFASQSSRQGMFSRHHSMVSIASSVEESESRSCSNGYSASAQKSSTNGKQGQTDGQDTPSLSTKHLLYIQMQFCSQKTLADFLTNKDARQGPSISDAVDIPYALNLFLQIAQGVEHVHTQGLIHRDLKPNNCFIDESGVVKVGDFGLSREAGETQEDDNTVDLGNDVSAIGDITAGVGTRSYASPEQMKGSDYDSSTDVYSLGIILFELCYPMYTGMERYIVMNQLRNQCFPDQWNNCMKPAFPGLHSLLVSMISINPRDRPTAHVVVERIQSILGGLTISSLDKKHQHEGAILLRIEAQPREDVLRHTIELLKESARPTDVDVLQYGLRGGTNEAVMEFAISLVGGTSQDTSSMVEILVNRMKEYPEILLIRQVSATKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G894</accession>
    <name>A0AAD2G894_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS21687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G894"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="691"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="766"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="697"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="766"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="839"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="896"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1063" mass="113394" checksum="54F0A1B3BC598751" modified="2024-05-29" version="1">MDDIETGKLHSSSHSNHSMNSGHCKLRRKRSKDSQNWSERSKQSHHHHHGEHHNRHHSKKYDHYRNHHRSKSHDRSENLQHSSHSKKHYHSNKNHHRSKSHDRSENLQHSSHSKKHHRSNKKHLRSKSHDRSESHDRSKNPVRSKSHDNLKSHDYSKGHHHLKNHNYSGRSRNPKPSKSATRSKSPKRAIDELRKEKRRIEEMMFRGTKKIGMKIGGSKLELGGPFDNHSSLGNSHGTFDTLECFEIAKEQKQFTKEEQIRDLDEALALYGFAEIAARRIQAVFRERQQKRELLKELEDTEDESDELKTGDDNDDASTKDKSNTITIVLLALFFIVMTGPKLALTCWNGIKKCFGGNDAGGEEGMANVTVPHGGEGAVGGTGPAPTGGEGGAAGGAQAGAQGAMATQAASSAASGAASGVASGAAAGAAATSAAAAAGAAAAGAGITQVAAVVVVSTAAIAATTAAVVNPTPEPILSVCGLATPDIRSGRMVMLFEGVPRPFDERESGLVSNLVLEAYNEITFGTNVVVMGCLDPLAREMRSVSIVNQTLSILTDRLVSTMLEVVFEAQVSCDRCSETNPLFSEDQLDSTDTSGNNTDATDNNTANFDVASNATAEGVVQLDKDQSRLLQTGGFTVDFSSQKFFQKLIQLVIFETEELSDKGELPEGFVQISKALVITNDAEEEELVTEIKYKREPGQGGGISGGGGSTVGGGGGSSGSSGGGSSSGGGGVNVRATFEFEFVDASGQVQKETVAITVEGGAVPTTSFPTFQPSHSPTDLPSISPTNVFSGQPTTFPSARPTNMPTGTPSIAPSGVPSSVPSEAPSPAPSILNSDTPTLSPSMEPSSMPSMVPSARPSRSPSSIPSLVPSEVPSVVPSFVPSEIPSFVPSFVPSEVPSMQPSMVPSANPSAAPSESPSSQPSSTINLIVPGFPGSQSTTHSAGYEAFRGYDGNFASITHTALQNDPWWQVHIGAGWGNRPCTVKTVIVWNRRDCCPERLYGAYVQLIALNGNLIQQQQITNSIGFGSQTLNFGAVPNVYFIRIHIYGAARILTIAEMQATGYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8T1</accession>
    <name>A0AAD2G8T1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8T1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="333"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="454" mass="51953" checksum="1A46A1AA6963223A" modified="2024-05-29" version="1">MSENMDPQRANEKIIADELSKISFKEREEAYEDIHGVSDQGKETSELIESSLGQMQHYLKSLSDKYAYDVAESLSKDYVTDRGLRLKFLRASLFDPKEAASRMAGYFRHKLDLFGWEKLVKNITFEDLGEDSMEAISQGMMHQILPSRDTQGRAVICGSHRLFHDQVVRYKDPVKTLTKAFWYVFTSVADDEETQKKGFVFVSYAIDSGHPSDATRRAAAQSCAIIGRSLPARATAVHFCLDSQEEAALWRVMILSSPTYTRVRIRTHYGSHNETKFRLMSFGVPINDFPFLERGEVKKANHFKWIERRKRKEEYLRTRSLPKNAIDIPSRVDVILGRGTPFNSHPGNKRLHEIVADHYDEYDRETRVGKTKLAEMIVVMVHEYGGKFMKLDDECGMWIELASLDARNKVAHSFRRKRGFAVKGPEAVKVATGEDCGCDNKRLRASRTKLDMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9M2</accession>
    <name>A0AAD2G9M2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamideisomerase</fullName>
            <ecNumber evidence="3">5.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9M2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="259" mass="28528" checksum="BAB12C2201DBB913" modified="2024-05-29" version="1">MKFRPCIDLHNGQVKQIVGSTLNDETESDKLNTNFETDRPSQDYATMYQKDKLLGGHVIMLGPGNTEAAKAALGAYSKGLQVGGGINDTNAKEWLEAGASHVIVTSHVFANGQIHMERLKKLLEICGKDRLILDLSCRRKPDAPEGDYYVVTNRWQTFTDYKVNAESLKELASYCDEFLVHGVDVEGMQCGILEDLVVLLGQHSPIPVTYAGGVRSIEDLELVKRLGNDKVDATVGSALDCFGGELKYVDVVAWHNQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9P2</accession>
    <name>A0AAD2G9P2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9P2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042153925" evidence="2">
        <location>
            <begin position="17"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="378" mass="42003" checksum="E0726CEB50D0F41C" modified="2024-05-29" version="1">MTRLIWICLLWPYIFCFSFNARAHTKARTSTHLFSSVGINDCLVVLSADAVLDTVEHRSQLGLEAALCAWPSLKVEKEVLLQDPTWLLNKLKALSHVLDAPSASFSTTCEFALAARLLLEEQALDEGESNNKRGKYASKFHPQGIEDSPSSAEPSSSSTRPLTVGEIAANWDDFFRETLQMRYHANYKDPIPVLQSIIDEKIVDWGELPVFYPQVQHTLNSKRYQNFVMTVPPSDKQLVRQSLEGANVSFIETASALVAIESLSLETNRRTVVVLESDESSLQDILNSSIGETVIVVIDGSYKRLEAMASLFGDSIPRQGNIGNTPFQKKLSLNLGKWACGHPTTVAKATMNPWTDVMTMEALQDNFLSGQNSEEAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB22</accession>
    <name>A0AAD2GB22_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002362">
        <property type="protein sequence ID" value="CAJ1968101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="494" mass="55622" checksum="2ECC052CA631325E" modified="2024-05-29" version="1">MANRNASYVFGQDSIFDVQDDCNANDGIDSMLSRDQRRTTNHYYGQPPRSKAAPGKYHNNNFYNPNKYPILEQSNFHNHQISEADYLDQMVQSVERRGRYSTQDYDEEKQHSQLNSSYDNEDDEEETQDDGEFYLATANATRMIPVDGQNKLATNNGPNNVLAYILGGFGLCPPDEHGTKADAQVSHFETNFGNGGEVIGTTNHTTSSSGGGGGFNICAPDPKGLATDAQVQRFTATTEPEEPASVPGGVEVKRPLPKPQAKKTTLQQFRERKLKLRQKHPLQEEKKESSDLQDTAAFPFNTRQFSDAKKQEQQQQEPEEQLHHQLQLQEEEEELLQQLEEEQRKEQLEEDKKMDAVVDSGMDLCAIPGCPTSSPKRPPGNLALPPNASDFPEDPFEDKEQNLFDDGEEQSRLDQIRQKKRIIEHQVETEYSSQNRVQVDTIYAASSGVLQTAPMSLQNKAIVSFLLFLFVAAAVLVAVSFFWPDLMPNRGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBG7</accession>
    <name>A0AAD2GBG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS23308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="102"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1968585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="243" mass="26374" checksum="35AD3E6F254D247A" modified="2024-05-29" version="1">MLLLILSTYCSEALDGVCKANRDCLHDGYCDDVSNQQSHVYDSKCICTQNYTGPYCETPKIATALDCVANADCQNGGTCKFLSISSAGIQSQGICECPSDHYGYHCQEKCPCHNGGSCNTEYSTGAYECQCTKEFYGPLCVFRWEGEREEADTGKAMLISIVAISFGIFFCLVCSIASSSRGVGNENIGKKVGLERMEDGTIVYRSKEEEGENKAEGGIPGTPRTDPVLDDSEPDNLTDLELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBS1</accession>
    <name>A0AAD2GBS1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBS1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042262881" evidence="2">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="122" mass="12942" checksum="BB82FD79F217BE55" modified="2024-05-29" version="1">MALQTSTNATTSFKILFLFAVLSFCMLMAGSSSGSGPILFAEASSSADATTATTTTTTTTATATATATSKTNHNLNKMFKGMSPGMQQKMSFLALTTSKIDAEQKAAIRKQFQRTFQKRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBV2</accession>
    <name>A0AAD2GBV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protochlorophyllide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBV2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1969318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="38063" checksum="14F9A84FBC7B3594" modified="2024-05-29" version="1">MMISSLQRTCAAFAVGIAKQNVRALSAVPPLHHSRSIVLTTSSKSSPSSALRLASTFQAPEPPQSKGHAVYNDIEISTTEQESVARNSDADAVFVVTGASRGIGLQFVKALQTRSKGTIVALCRNPGSAQGLNDFISSLSADQQSRIKVIQLDLEDQASVDSAVENIKSSFDRVDMLLNVAGLLGDGKDTPGPERSITKIERDWLTKTMNINVIGPVMLSQGLAPLMEQRRRRGKNDDSDGRAIAVIANLSARVGSISDNGLGGWYSYRISKSALNQATRTMANELKRKSVWCIALHPGTTDTDLSKPFQKNVQEGRLFPVDFTVDSLLGVIDSMKEENTGGLYDWAGKAIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC81</accession>
    <name>A0AAD2GC81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS23834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase C-terminal" evidence="6">
        <location>
            <begin position="359"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1969676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="57054" checksum="52CDB0CBB775AE77" modified="2024-05-29" version="1">MFWSKKLSSNTVIASPETNPRNHSGNGGRSHQNLLAEARAQVRFEEESDSVFMALANFAGNAILAGVAIVSAFGMATIVLCLYLIVRPFSVSIARRLSAQLGASSWLDALSLIMPNVQIKLTGDSDIPSPVGTSILVSNHMMDGDWFAILMLGRCVGLRGTIKAFLRNEILNLNQPSERSLTRTNSTSSTRMMRSPSHVTVNGSPQRTTTSSGTSNGRHPHPVDLSLAAKFLHTFLEFPLLNGDDYITDRENLFQLLRSFADNDGAAAPVHLLLFPEGWSLYNEENRKDVLARSNEFAKRERRPQLKHLLLPKTTGFNASLDSLRESSPVVYDVTIAGRGYDGSLPPKFDLSIISLWNLLRRDYPQQVHVRIKRYSMEEVLADSSWLDKKWAEKDRLLHHFARHQSFPADRGFARYRVFESRTHSIETSLVSLFRLLLVPCFIPVLLLLSIPIVWTVTWLWIFYSSFKIVFGTDGRPNANTSDGGATPRPDSNPGTPFVPATPFASPMLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCI3</accession>
    <name>A0AAD2GCI3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCI3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="296" mass="33846" checksum="409F6E8CB1E00091" modified="2024-05-29" version="1">MSTTTNQVPNNNNEVLLAEEKLRASDGDLQQEHPTNTTNGEAGSGCPFAHSSTSSSTRDEEAMPYQYIPLRMGGRGGTHMVSEASRALIDNEVTLDDLKTMTGAFYELAFQDQTLDKLIRSHEDPHGNRFAKWIHQKLSGSNVWDMDRRNRDKTPVQVAGGRTAVVHDRSSAHAAAWYSPKRPREEVGRHFNLYECRVWMRLHFYAMRKTGIMEKSPSFADYYVRFIAHFVAVYERSAPMFARDSLRWSENPANVEKYIDDGRIMTDVLGRGYSDSTRDLPESELYDDDWPYYVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GEF2</accession>
    <name>A0AAD2GEF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7640 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS24432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002513">
        <property type="protein sequence ID" value="CAJ1970414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GEF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019524">
        <property type="entry name" value="B-solenoid_diatom-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056057">
        <property type="entry name" value="DUF7640"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22534">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22534:SF5">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24646">
        <property type="entry name" value="DUF7640"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7640" evidence="3">
        <location>
            <begin position="654"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7640" evidence="3">
        <location>
            <begin position="737"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1970414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="877" mass="92320" checksum="A7B25AF654870485" modified="2024-05-29" version="1">MSNHQQCKVDDLLFGKEDEKAKYRSSGGGSSSQKRSKHKHKKKKSKPGVTQVKSSSPTDQVLFGDDEKAKAKASRGRSGKSKPGIVRVSDKPAKNNGRGQMSSNNSNNNTSRTAHDNNKLTPATIAPGSAPYSLATAGIIKGSAGHGDAADPMNNFGTELYSDTKEKKKSPSSEDSPSNTKKYAIIAIAVLAIVGGVVAAVVLSGGNKSNNEDKAAVTSVPQVIVTPSPTTFAPTVSTQSPSAIDPNVPSQRDCQNIASQLHVTDQDQLISKSFRVDLDVVPLTFDSDPADLLQQVVTAFRQRFAPSLAGCEPTTPGGGGSRQRRQLRNHQQRILLEVSDYNVRNALATGKHLEGMSCDGDNNAQSTCYRFQIILNLFLKEETSDFGLINLIMQLIGDPEQAVQRLDLVDACRDIRLTVSNINESSAPSNASSNAPTPQQAGLPTSSPSTTPPSKAPAVGSTPDPTASPSILPSAAPSTPLPTQSPTCSGVGRFFEGGSFDGVSGSDTVFGHSCRTDDKDLIVLKEEDNCGVQCIGVLEGGNLDEDRCASGDVEFAIAVDTRNQWLLIGYRSTSVNDELASSLNCPSNVLQLFTPAPTPVPTPEPTPAPTPEPTPEPTPGPTPPPTPGPTQPPTPPPTPFPTESPVSLAPTCYKCDGGDRQFLACQGALEELVGCNSCIGMGACEGMQTVRGIATNSCLGPFACWLADIVSIGQRSCSGDSSCQGIGATSPNNGQGSRIGTESCIGKGSCQGAFDVTVGAEACRDFEACTVADGTIGSGSCIGIRACHMRESKISPNSCKGPTACAFAEDWLSEANWCLCRSQGPANWCELLYQEIQLCGIGEWSRLQHPKSQQSRGQSRGAEQSHETSDGSGRWFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIK5</accession>
    <name>A0AAD2JIK5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001834">
        <property type="protein sequence ID" value="CAJ1953567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIK5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="113" mass="13209" checksum="7E808062239A9745" modified="2024-05-29" version="1">MASLQKRNGVARGNVDCDMLRLSIMTMTVFAIGCITLLSLLDYYRLIKPSLRTIHPAEVTQQEEKWSMSRLSIKPSLKRIDPEEKKWCPSRLIKPSLRRLHPAEEKWRRSRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIN7</accession>
    <name>A0AAD2JIN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001866">
        <property type="protein sequence ID" value="CAJ1954277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIN7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="584" mass="66234" checksum="BAEE341904382175" modified="2024-05-29" version="1">MYTGGFSSVVDLSKFFYNFPTHPEDRPYLGLLHPKTEELLTYYGLAMGAGNSPAIACRIGLAFVRLVKEKFDVFQGEAKANCYWTGFQNNGFDPKLGYGFILTSADGGAVHIWVWVDDFLIHGPSHEKTTRALAFFLDTAVDCGFLFHPKKLVPPQQVVKYCGFLFDTTDIPCLRIPESKKDRALAICEYLLQSPTHKKWSQLSLAVAVGVLESLTKATPRRLGHTHLKEFHTLVHPPGLGIGAEPYYTTTCLNSQVLDELKWWKQFLLRSEGRYVRGWEAATLVPTFGDGSGTGTGGTLQLPNCDFEMWRGKWKPAVFIFALKETLLRIKESPQAHLVIGTTVFYFTDNSGVYWIATTGSSKRRDLHQLLSEIRLLELDLQCVLQVIHVPGQVLITQGTDGLSRGVWMSTLQDIMDSDRLTQAIFDPMPLDWTLVWQHLPHLAHMAQYRSWNQQWTADLCLHQTTVWCPPPELARQLLTFLLNSWVECPFTTSAILFVPRVVEASWRHMSRYIEEIGTIYPHQTQLRFPPLLPIPIVVLHMAPHTLSLTPSRLDKTPTTAPSWHAAQATLMRRLRDEIHQESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ60</accession>
    <name>A0AAD2JJ60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19946">
        <property type="entry name" value="GlpA-like_Fer2_BFD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052745">
        <property type="entry name" value="G3P_Oxidase/Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42720:SF1">
        <property type="entry name" value="GLYCEROL 3-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42720">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="370"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="BFD-like [2Fe-2S]-binding" evidence="3">
        <location>
            <begin position="594"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="76623" checksum="26E723CF48998943" modified="2024-05-29" version="1">MVLHHQHGVKGVYRGGEWLDIEDCDEVFTGIEDQCSGCKIEGACPRSRSRPNASSKKSKGTDYDVVIIGAGCVGAAVARELSRYDLTVLMVEAADDVTQGATKGNSGIVHAGYDDKPGTNRSKYCWPGNQMFPQLDRELNFGYQKNGSLVLATNNDEVKILNDLLKRGETNGVKNLRIIDKKELFEMEKFVNPKSIAALYSPDAGNVIPYEFTIALAENAVDNGVELRIRREVTTIQRITDGFELTMNYWEPRDYAIFKKDGDQRKITKVEMFIIIVFPMVGIGISSYLGIIQPEKFIPKIVTFMAVMVGISMLFNWYFVPATVFVRRHTNLIPLVAKAGKLESEKGPKVTVADMKVGGSGSKEIQKGLTMENEKVTAKFVINCAGSYSDQIARMIGDKSFKIKPRLGDYLLLNRNQGHLTTRTLFPCPDPVLGKGVLVQTTLWGNLILGPTARDTSDPAAWGMKRNEIQHYILSKCKNLLADFDPKETIHAFCGARAKSDRGDWIIENSSVDGRMIHVAGIDSPGLAGSPAIALEVVRLLEESGCELKKDPTFNPRRAPIITPKNGMRGLKMGVVGLHDSYDQTNEAVMAKNVICKCEKVTELEVVRALRRSLPIDSSQGIRKRTRAGMGHCQGDPKNYNCEARVRAIIARETGMPMRFVGGRPWPATSTLMQRWPQEEELNELERLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKY7</accession>
    <name>A0AAD2JKY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5672" evidence="1">
        <location>
            <begin position="154"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="332" mass="37630" checksum="E681B45ADEA8F615" modified="2024-05-29" version="1">MVSSGSTFWRFIAVSFAVAFLAQTLLFATYFHHSASNADQNAVPAVQAFVVDSKKHDDMEPSTPNRQLETVLEGVAVSVMLKAPKWFHRRYTVMLHNALANFPISWKIQVFYNDRWLEKDVLPLHPGLRKMKSGHDRIIWTQIPEKMTRWKPKDIMKSVWLWENMEHDNVFLFGGNGAFCGNTDVSLDRFLSYDYAGAPWNAYGGNGGDGSSHSFRHRSVMLEILKEHPPDDGDQDYKYFLKHMMKDSTKYKIADRDTTLAFGGVSNVTPLLLSGTQPHLNFTTRESILFICPELKVIFPSLHEPTCFGAHPKPETCQSSICALNDIPPQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL00</accession>
    <name>A0AAD2JL00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phycoerythrobilin:ferredoxin oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HY2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016636">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010024">
        <property type="term" value="P:phytochromobilin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009249">
        <property type="entry name" value="Ferredoxin-dep_bilin_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34557">
        <property type="entry name" value="PHYTOCHROMOBILIN:FERREDOXIN OXIDOREDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34557:SF1">
        <property type="entry name" value="PHYTOCHROMOBILIN:FERREDOXIN OXIDOREDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05996">
        <property type="entry name" value="Fe_bilin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042205439" description="Phycoerythrobilin:ferredoxin oxidoreductase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37885" checksum="A43707C6A39FBA29" modified="2024-05-29" version="1">MMVIKLIFNHLLLAFLALELVQSFTTTTIQWQPSIVSLSATPEYDSKDYFVDPNNVGLYRRFCDHVQEKLQESGMFESIDDLPSQLSLNQATQNRGGTSSMVQIQNFAMKPTGSFKDVVRYSRVALLETIDLSNSSSGDDGTVVTHTEGIQVLNFIIVPSAQTDLPVLGIDLVRLPGDKNLLLLDAQPMVDPNPYQENWKAWYAEHVGGDAPVFSWGGDFPPPVQQYVSPYALWTRLQPPQEVSGSEDKWDPTSIIQNELWDAFTSHLDIYLDLLRQQQQQQQLQTDSSKTNNQAGYLEYRRTTDPAKPMLKALYGEEWTQQVLDEVLFPTWME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL66</accession>
    <name>A0AAD2JL66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">subtilisin</fullName>
            <ecNumber evidence="6">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS18793</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040002065">
        <property type="protein sequence ID" value="CAJ1960575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL66"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042087540" description="subtilisin" evidence="9">
        <location>
            <begin position="29"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="11">
        <location>
            <begin position="92"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="192"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1960575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="586" mass="63304" checksum="7430181802D09066" modified="2024-05-29" version="1">MMVRHSHSMIVLLSQVLLGCLLASVANCELFDFFDGGVDRTDTIDTAQQSSYYNPQEAGGGGGGDDEEMIKIMVGFRDKGDGNNYKRNQRMQSRDGSSKSKITYEFQNTNGMAMEVTRAEFEQMKQDPAFSTVEEDVEVRVATPATPTANNNTMEAHERWLAEARSYGLAMTQADQAIPVPPSEWSQCVAYMCIVDSGVYVNHNDIPYNRNDGYTDGSAFGQAAGDQWWNPIKTPHGTNVAGIMFATGGNDAGMVGVIPQHPSQSKVCLRVAKVFPNGQEVTSVSAILQAVEWCASVTARNNKPMVINLSLATDIKTSTEERVYQRVYDQGVLIVGAAGNLGNAKVSYPASHRSVMSVGSVSSNKQRSSFSQYNDFLEIVGPGTDILATNADGSSIGTLSGTSFAAPYVAAIAARIWARNPHCSNEQVRSSLRDSAIRLGNGVPNQEYGYGLVQAVAAYNNLVNKNCNKPTPAPTPYPTTPPTPPPTPGPTLSPSKMPTNVPSMEPTAAPSIEPTETCQQRLFSCERDEDCCRGLVCAIDSLETTENWVCRASTDSGMRNKPRLSQMDNSQCRGGFAGGCSKYDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLD4</accession>
    <name>A0AAD2JLD4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLD4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="128"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1130" mass="128347" checksum="6317D7169CE3EAB4" modified="2024-05-29" version="1">MNQSTRRKDSNGSYDGHAANDNTHAEEQPTARTALESTFFEEWKDHHEEVEDSSVITFDLMTRNALHLKDEESGSFRSYCASPTTSRSSLRTSSRLSEVQIHETGNSRYERVLEELTINKLNISSLGVVGRNKEKWVLQNCFERLCQGKDGEYVHELVLIKGYSGIGKSVLARTIQKKVETSSGVYVEGKYEFTSTDEPYSGISQAFGKLCNKFKDCPSETRNKISSAIKENLREEAFMLMGMIPEISVFLDCDESRSTGLGCITIPGGREHERWKYAFRTFTRILGSHFSPIVMVLDDLQWADISSLDILDHLLSDFQNPHLLMIVGCYRSNEVDENSILFNRIQTLEGKCQKGIFRLTDIELQNCDVDSVNKIIMSMMDIDDESETRELAEVCFKRTLGNPFFLIEFMRMLHSEGCLEFSLGLLKWKWEVAKIENMTMSTDNVVDLLKSRMSKLSNNVQLLLQYAACLGASFSISILEFVWNEYSRALRFGAEGGNVESMMKTAQNVQLVESCGAGELRWVHDKVQEAALSLSNLVTPSFRCSIGMFLFHGLDPIQLEKQVFEVADLVNKGGVTGLLDVAVLNLQAAEKARKIAALQSAAKYAEFGIAQLPMGKWKLHRGLTLQLYSLGAEVEYALGHINKAEEYIAIILNREDLTAMETLPLKKMKAQILATAHLRWHEACDYGLVILKDLGYNFVWSRALVPVQMLMAIKNLAKRVKKVKVEDVENMKVIKDEKQRAIIDILKLMKHLTYSANTLPLCFLCVCKVIEMTLDHGLSLCSADCFATFGGVLMFLFKDHAAASHVCDLAFAFQNRSGRRHIADTMHGAWAFVLVQTKPLHEGLHLTMKGYSEGVRDGDPLDSTNCLINRFVLLPYMMGRSLESIIEQFPKIAPQLEESGITNNILTLKVWWQMMLNLQLPSVRTATRLEGEKFRQSEEKAESNMYIGNVNLAIGELLLFFGEHEERAKRLLGEEKGKTYSELVQGYPPHGIETFHRGITWYAMARKTGKRKYQCRAAKVRKEITKWVKKGNPNAKDYDLFLRAEQAVLDKKYDKANTFYKKAIVHAARIGHLSHVALYNERFAEYRLEVHGDGDDYEYYMTEAMRYYAEWGAHGKGDLLKHELYKIHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM94</accession>
    <name>A0AAD2JM94_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1740.10">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="AlgH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31984:SF17">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31984">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (DUF179)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="514" mass="57140" checksum="268C9708B10F6346" modified="2024-05-29" version="1">MKQGSFSLCRIIGSGLMMTTTTTTMMMMMTILTIQLEQVQSFSNPPPALLQGSTSYSVATMPRRVPCTSLRNALFDDNDDDDEEEDDFIDTDSLGDWRTFRRNLALETPPLQEFDDDDDADQETPATTAAATAPIKSVSKANEEILLSQNEKLAAEYLTGVWAHPVATPEVGGLVARMPLESELFANYKHSILGKHLSKLLDGERDVDIWYKRAKKLIQEEMKKIAMKADEQGQIDATTLDEVSSEMLTLFLDNQDNWQEVCLVVEHANSIAKTVVLNRPMAFKLTDNIARLVLQGAFATRSSDDDDDDDDDDDDDIDDDDQSGYRLMSTDYYSRPSDAFADRKRLVRFMTAFSSECAVYVGGPDKQNMPALMIHGIPDLPGAKEISPGSKIYQGGIEAAVSGVLEGEYSPLEFRFFIGCHLYKESALDVAVRLGKYQPIACARSLALKQCISLPKPLWHEVMELCDGDLGDLSALEMSSSDDVQFQVVDETEFEDGPDGGLDNMEDEDDDFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JME4</accession>
    <name>A0AAD2JME4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JME4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="170" mass="19136" checksum="7CEC76F7F6554827" modified="2024-05-29" version="1">MTPTRTIPINRDPQILRREAQEAQMVRMAEVQDHMFYNRLVNGMRERQAQSASLPTNSKMEGERQASFMEKLPSTPSLSGVPVSVLMSPDRSRRSFHYESHRHQSTASTVSTSPSNSVLSSSPRYAMPMQGHLERADLCNVLTQSIQILDEENGCGGGAEEDELMFEMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNL1</accession>
    <name>A0AAD2JNL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNL1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="222"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="297"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="372" mass="41745" checksum="FFBDE17489B333E9" modified="2024-05-29" version="1">MAFLQNNVNAMNSNASFNSSLRMYVEMIEACTALEQQKLLQNLRHQLAPTPPAPTGVAAMPNNTHAISPLLVAEAFNTLIKHQQQQQQQQQQQVNANPLVLALAAAANQPAALASALTQALVNPVGSPAPSVHGILNALTRQHPSVSTTSSASSPLPQSPAGILQSPYPAAAISGMVFHQSEVVAKRPVSDISSSDDSSGSHPKRQRLACSYEKDTSFLHYHDEKWNFHYNELVEFKTKHGHCNVPYGFEENKALSRWVKRQRYQYKQKREGKTQAMPESRIRKLDQLGFVWGAQELLWQTRFHELKEYKLKTGHCNVPYIHDPNPKLAIWVKCQRRQYKLSQEGKPSNMTVCRIKALADLGFVWTQRKPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP88</accession>
    <name>A0AAD2JP88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="161"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="227"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="294"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="390"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="456"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="531" mass="62849" checksum="9781D0BC1E3BC7D5" modified="2024-05-29" version="1">MACRLSSHGMLRLIQRQLCTASRFTHCHIHQSQWNGFRIQIAAPLIIPSRQFSSVETSALSESIDDDELQKHLSVEDEAMLNQLLEYKNLHGDCHVPSGRGSFAMLERERLGGVSDDLAEWVRKQRTLYRSAQRQKGKLSEAQQIRFLTLESLGFMWSDRDAQWQRQFNRLERWALENDGSHEVDRDSDPQLARWVEKQRKEFQQGKMTQARVDLLEELNFVFSLRDAKWWEFYDKLLVYKEEWGHTMVPADYDADPQLGHWVSRQRQRRQSGLEEDRIQALDDIGFSWDVLSDTWDKNYADLCDFYAKNGHTRVPTSSPLWSWVDRQRRTLRQLGLDESESFDAVQKIEKLNKMDFGWNDTEGLGEDDDTTHMRAKKLLELPFQAAVYDDTWVQHFQELCEFQSKHGHFAIPYTGPYSDLSNWVRHQRYLFKRDKLPEERIAALDGIEFAWTAHTARWDRMFEELVRFHAENGHARVSPRNSELYRWTLQQRRVLRAKKEGDPDYQVLPGDREDRILELERLFFEGKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPF7</accession>
    <name>A0AAD2JPF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPF7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="417"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="59135" checksum="4E5F62E3CA2D7F6E" modified="2024-05-29" version="1">MTSSLSNNSFAIQACLPYFNDDDQAEGNNIPNHLKKKNNNDRIASKPEMKQTEELLSSEMSQLSVQERSNALDDLHCVGEELRETPEMIQRSLAEFEDAVRKERNPVYEMAVNQNRAHVEDPKFRLKFLRAKLYDTRKSVRKMMSFLECKAKYFGNDKVAREIDLSDLSKEDMELMLSGLFHVQDERDRRGRVVLHFFGKLLRRCKADNLIRISYYIIFNTLSFLPDVQRKGIVAVYNDATLPGETFSMPGFSFIKEIQGFFDSGPLRFSGIHYCLHARGHNLALNNAIASLFLNGMAQCDRVRTRIHYGSIMELQYQLQSYGIPLSTIPFGVRGNIRNDILNVWFERHLKETNQSIRLHELSQDMEIESDLMGYHVPQEQKDDDARYALLMDPWQEGGDTVHTSGMSDSIKPTEMDVLFGKGYRLQLHPGNVRFREFLEQHRDEYESTPRQNRRAMAVELAQSLRNNGARFLQKAESGEWMESDNSQAEKKVSQFFRELRKKKAKEAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU33</accession>
    <name>A0AAD2PU33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="169"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1172" mass="132306" checksum="D77420C0DB25B9BB" modified="2024-05-29" version="1">MLSEESIIVQDDFMRIKEHHISAVPGTPSTTASTPQTNLRYLHHSGSMSNMPKIKSLLSSDDDSSETSELEVSRRSGPGSIRMRKRVKFQELIKIKMVEKPDPLVVQKQRKRKEELAAIDNKLKMDAIGVVGRQEESKTLKECLERMVTAKRSFDKAMKFDSGFLKIPSKELVLIRGNGGVGKTTVARKLRSFVARSKGGLFVEGKFDVDSKVPFVAIANMFRKVCREILSMCEQSASHIGDILYTELGDQRDILLCLVPELAEILGDHIDSDDEDSGSGTETFDAEHVQQRSKYAFRVLSRALSAVVSPLVLLIDDIQWADMASMDFVNHLICDEQNPNPFMIIGCYRSNNNDEMLPPNSPLMERIQSMTESQDNFRYNLTEISLKNCTFDNVQEMLMAMMSIDDKDKVEGLAEICFKRTKGNPYFVIEFMETLTHEWLLKFNLVSWKWTWNEKEIEKRTFSTGRLVDMLQSRIQHLSVPAKTFLQCAACLGSFFQKSIMTVIWNEYYNGSEAASVEDLIKTLSDQRIIEQASTGDYDDDFNNGDDDSDDSDDTFQWVHNIIQEVAQDLLLLNGSNKSVRPKVGRILLHFLDKEQLQDHLFIVADLINHGEVTAGNAIECATLNLRAARKARNIAAFQSASSYASNGILVLPRDKWTSHRELTVELCTMGAMMELALENGEAFDDYSAMVFDQKDCTEIEAMPLKVSRVCKLSTVDVEYQEAVDYGLATLKDWGTSILRTKWRLPLQARTKLSKTICMAKSAPAPEDIHDTLGTITDPELLNTMKMLSNLGNACWVSKQVFLNILVICKIVELTLKHGLNDAAAPAFASLGMLTIAVRHDVKTGSRFARLALAIQDHMNASSKAETLFIAYTYCLCHTESLESMALPFSRAYSSGLSVGRNDYAVWSLVCNRILVPWMLGKSLVSLRGYCPEVLSQAEDVSQRVQGTVVKIFWQAMINFFTSSPDGSSEPMDVRQLSQLEGKIFSAKNYKGTDVVALACVHLVQGELLLFFDVEKAGERALEHGDRFVNDAPAMFIGVMETFHRAVALYAMARKTKKRKYRKAAIGLRKRIEKMQDTGNPNVKHYDIFLNAEQAALDNRNDLAETRYRRAIVYAARTGHLHHTALFNERYAEFLNDVKDDEYEARHRKNEAIRFYREWGAFAKASELSKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU91</accession>
    <name>A0AAD2PU91_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="229" mass="25150" checksum="F59D2C693DCD6250" modified="2024-05-29" version="1">MASLQDTLQLNNQAVVLHHSDNLAQAAKAYHESLSFFKRLLKECYHHNQGIALSTVTQYECFHTAAPTNAQRDVSTQSDDEPFVYQSALILQETQSYLHNTQAMTIYCAGVVFNTAILHHRQAIKTGSSASLDRAAKLYEASLQLVLGQHIPAGSNSTVSLIAMAASNNLAQIELEKGLVCQACRRLQFLKILIQSLQHIVTRIFTMDEFQGMLSNTLSAESVTASPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUP0</accession>
    <name>A0AAD2PUP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS12738</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="8"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1950750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="380" mass="42626" checksum="82672A7A732B2D79" modified="2024-05-29" version="1">MNTSVDDGDSRCAICYEEFGDCSEFDEEDARCMRVNVKGCQHLFCRNCLLHQCSYSLSNRDYPIECPASPTNCDNTITDEQVRDILLRPSAEKADDSRRGVAKWRDYLRLKQLSKDPTLMPCSRCQEIVSKAEHIKDEITCPSTLECPSCRHVFCSIHGDAHPIQSCAFYNKQKTSCLDRKSERLIRTNTKPCSHCGAPIEKASGCDHVVCPSCGDDMCYRCGKHDLTGNTIRVCQNCDRSYVDHRRIWKYRLIICLSLPLLIPFVVAYVVLMAGISIVSLCCCFCQCVGLELDEEGHKSFSLKRGAARVTLVVFLPVLDLLDTFGADCGISAMLQKHGLEQHIPSSQHTITMMTRTGADNGKDDIDSEDYESDSSHEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVG8</accession>
    <name>A0AAD2PVG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS15620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1955173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8282" checksum="C469655704082A66" modified="2024-05-29" version="1">MAEETNPSSPAANPPNKWKLPDGIEDHIEDGLIKSAIGATVGGVFGMILFRSGGGMRSASVAAGVGAAVGSTYERFMSSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVZ8</accession>
    <name>A0AAD2PVZ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001974">
        <property type="protein sequence ID" value="CAJ1958366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVZ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="YhbC-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="344" mass="38953" checksum="1FA89C89B7D7FBE3" modified="2024-05-29" version="1">MNQSRLYAGRSRSRVTDPAGPTPVEEEEEVEEISLEDVEEFKYDPNNHPIPHQPWRRGITAGCEDPIDASWRIRAEALIEKSIEMTGGKLIGVTWFLAHLLITIDDDFSEVPRDLLKTSGPVINVVEPENPIFRDPADPVPEDIWADEEIEMPSNDEVMEAAEDLKSKMYARPEEGEEPLDLDEEDIPTFQSAETREDKALRVAEEASERINDLEYQIDIEALRINTPAISSIAGAIIEALETEEKELRILERHEIVLCSPGAPDVLETQKEFDSHRGRDVAVETVDPWDSNRTLRGKLLDRNSMDILINQKGRMVTIPQNFVKCVRLPNEKGKHEGIEDSKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW96</accession>
    <name>A0AAD2PW96_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002018">
        <property type="protein sequence ID" value="CAJ1959763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="772" mass="85993" checksum="617AFA4231A288AC" modified="2024-05-29" version="1">MWDKAYSPHDFRMFFRWNINRDQLKATVDDLVKFLEQGGKKPGTNVYQQERQFVGISHKVIDTALTHDFDMLELHEKICFVFLTFYKEGNEGEYYGPCICFVQSSGTGKTKILYKLCKHYKMNEEGTSKSGKGKSKSGTNIVGRLILCRNAKGESDENKKEKDLFDAFIDLRNGIDSNQSFQQVVDGVFKKLDDMIALFNIADEPTVLVLFFDKAHYLLDEGNYTKEKEKEKEKGNGKGKGKETKTTTMDAMLFCIVCLWIRKKRGNLQIVAVFTGTTAKLTNFITDDDITNKTDTNTCEYTSPKLEFYMRGEKTSYTPFYTTTTIGCLRFVKMDDSSSNKSGYSVAVPCGRPLFAAMSEQELKAGESIIVQRIVQDASPSSFKNTATTWLSVLGTRVQMRQTTFDAASGLVGRSYANLVSVSPATVNGNDKQTAKICFPPDPVCARLAMCLMDDSWSMALSKDTTLNGRPKVCGDDGDDGDDMMTQNNDCQVHFSAIQVCCNYARAYDDSWSLVQNEVFLENMYKTGVGFYVFAGCSVIDVVFALQISVAAPRKGGVTATSSSSSKRYQYVPMFVSIKLQSSFCPKSASIQCDKMKAKLEAVKGGSELGALCLLVVFGSSVKSKDGDYTLKPDCVKNLEEGMAVSKVLRIPTNDEFGLTEAFWELTGVHDEMSEVLASHSFLGAHREADSETTTNNFTGQVLRLRPKLKTKKAAETQGIVRKTDEVTGYLDKLLAGLDDIVRGQPSDGEKEKQKKRKANKEKTNKIQQPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWQ5</accession>
    <name>A0AAD2PWQ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="313" mass="35151" checksum="D1D634DB3937F3A9" modified="2024-05-29" version="1">MNTETDTLLPHHHHHQPQNDQQNNNDHNDQKMGYGGIISRVPPTIIEDDVSSSSTNSSQEVTVTVAVTAQTRQGRLLLAMTLLLLYIGLVISLLAANNFNQETVIERFYFLPFHMYEFWGSVYFALVEGYILLVADDSFFTMDPSSQSTLIHMLSINVVSTMTAASLFTLNPAIFEVTAHYIEYSSQLTVTLIDAYFMFLPRNGSKELRDRRKMGDNVPVSVQQGYFGLLLLADLAKFALYAGFIPTAISKERSSHYVEFTVEILNSLWAFMYIKDLYLQSLQSSSWQKNGNNSNSNSSSNNNNNKGGGVLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXB6</accession>
    <name>A0AAD2PXB6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002227">
        <property type="protein sequence ID" value="CAJ1965843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="236" mass="26505" checksum="2F9EF27770AFFB21" modified="2024-05-29" version="1">MTTKDTEHKVEFPKLLRNHLAYIYNARISFKSEELYLGDDNVLGAFRHRKWNPNVIGMHTFSIFGFLFFCTGLTFGGNTCASNFEIIALSRMALARFLWSQASTIARVLRYLPAISTSPEPTPDEIAQFTPAVADSINKGVFNSDGSRIPPNFDHHVDDCLYVDVAKTLRQTIASSVLALYLILGFPDASKGIRDCVSWEKFTTTFSHRRHCLGWLILRNEIVSSNGSGPFYGNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXQ3</accession>
    <name>A0AAD2PXQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002323">
        <property type="protein sequence ID" value="CAJ1967298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042047206" evidence="2">
        <location>
            <begin position="30"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="113" mass="12475" checksum="CD062C600320A417" modified="2024-05-29" version="1">MFKFATTWLYSSYTLFKLLLSIKATPAQADQASTAAKDKPSTATATDDDSSEEEDDEPQEGAGSQSGAFKKVTKKKVKKKKKKKSPLSNNLENHFLKDLSPAQRKLAEAAEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAW2</accession>
    <name>A0AAD2CAW2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1892826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1892826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="273" mass="31025" checksum="3FF484A856FBB965" modified="2024-05-29" version="1">MAVQHSIGPYKKNLEGVCITSKLKQLWSDCYENTSLTATSTTEGNASSSIHELQSEKEKAMRLVRKHGNPKQTRVKYVPFEILRALELLVEDGDQLENGLRGSSLYFTPPPQPQEETDEQRRYRLRIDRLKLRREETKYSKLTSNLQSKRNEDDITAKSMTYAASVGLNMIIAPLSFGCFMYFFAGGIFDYLWGDNASSRTPGGTDIKRVIVGVVSGVIMLFIEMILFVIRTHEFEVHQRRKQKKKGGVQPFGVYSKKISDPVALHGRPLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDF7</accession>
    <name>A0AAD2CDF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">YqgF/RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS1892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDF7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317:SF4">
        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgF/RNase H-like" evidence="6">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1930292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="230" mass="25810" checksum="1E632782C914F03B" modified="2024-05-29" version="1">MSAAAAITKESCQLLGIKSVGVDYGLVRTGVAATIGYEPTPLKILSNLNNTEVSQHVVQMCRAEQASQVIVGLPLHKNGTEANQTTITRMFAAELADHVIKNLGPSVSVLLFDERYTSKEAAARAHSKDPNRNLQGQLDAVAACIILESYYNDNGHGAELVEVDPTLYEECVNVWEEKRIHEEKRLQEEMRDRDARRAWRKEAMERDRTMEETASTNTNTKKKKKKRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDX6</accession>
    <name>A0AAD2CDX6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000147">
        <property type="protein sequence ID" value="CAJ1931431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="221" mass="25265" checksum="24FCDC65C10E8264" modified="2024-05-29" version="1">MTKKRSNSSQHEEEESVSEDQILLLENHHLGKEELATLRLVETTDRALELIDSLSNEPQRFEGDDPGDLFDKMDEMRQSLQSAWKDVLNDNDDNENDTDDSSNPRGSKRTRDGPSEEEYRSAYVETMAEVLEAPLDAMRQQHEQDEQQSTNGGKKAVLDMDVDLIVEALQSGIDLLHPEEKMLFLEELQAIENEGEQDDNEATNKGESIHMMRRKELGYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE81</accession>
    <name>A0AAD2CE81_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000033">
        <property type="protein sequence ID" value="CAJ1928073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="127" mass="14386" checksum="32076D797D838979" modified="2024-05-29" version="1">MCLFRYGSFVSFMNIIFKSRGCHAVGAFGSRGQRPSTDKYSLDLQTGAQLRFISSKLQGSVQQELKGDQSFPVQPNDVVELLESSEEYMENLRIAKELKELCKVEHKMCAAWALNGECERNPQWDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEF1</accession>
    <name>A0AAD2CEF1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000069">
        <property type="protein sequence ID" value="CAJ1928957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="113" mass="12593" checksum="8986DBB771F4D563" modified="2024-05-29" version="1">MLDDRSTSNSAFSANESEPPVTWNKAKLENLTKGVVAQHLGDVWAKVNNNQRELFPNGASSYGPRILMLLTQQNGFSWWMVLISGRIDIAVTEGMLGVVVECWARLRCSHMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEL2</accession>
    <name>A0AAD2CEL2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12693</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1397</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000033">
        <property type="protein sequence ID" value="CAJ1928085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEL2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042440649" description="Subtilisin" evidence="2">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1928085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1950660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17841" checksum="328EE17BA0035D44" modified="2024-05-29" version="1">MVPTKLHCFFAAFAAFLAFSSEAFSPHSNSVRQQTLLFSISDDEAKNIVWRHVKKPLLRLGSKGASASHGNSLKQLLEDHTAVKVKVNTMPYDGSLQNAYDALRDLAVENGAPETIELIQMKDSDKIVLIGSPGIIDQVKAGSFPPPPPPPPPSPSSSDEREEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFD7</accession>
    <name>A0AAD2CFD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apyrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS1004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1922972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24003">
        <property type="entry name" value="ASKHA_NBD_GDA1_CD39_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042080543" description="Apyrase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1922972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="61880" checksum="3402C4210AA73CE9" modified="2024-05-29" version="1">MGRTMNLSKNKIRVLVVALLVVILALANSIVSANTVESKSPFKIILDGGSTGSRLHVFEFVKKRNGEEKIIRRGSSKANVPISSFGSKASPSEVAEHMLPLFDFAAGVIPRKYHAATEVKYAATAGMRLLKQEEQDAVYTALHQGLTESDKFVFTSFQLEDLATLDGDLEGFFGAVAANYLHGIVDTNLRVKEEIEHDGPIGALDMGGSSTQIVFLPGEGNILDQQEGTCDPEDCLWDGDGIEHINGDDFFTTSYLSYGVDQFRQRLWNTLIDEKQSYCNSPYTAIYDGIDQLKKLLWSSLVSERLDEGLGSSDICVSKEVQNPCANKGFVAEFEGFHLVGTGDTEECIRHTQRLIPHPAKAHDNHAQIGNQVGGVKHPPVRGKFLAMSLYYFALDSLRVFSKANDEAHQALNLSWPNPSIEELHNALDGLCSRDWHEDMASEVGSHSFTREEVLPHRCLEAVYMVTLLKDGYGFHPESRDITFTFDVDGSEVEWTLGMALSMNAANSQIEAQKEEQASINTTFDDRDTESSMQALSSSNAAIIVTSSPSLGDASLSPSTYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG45</accession>
    <name>A0AAD2CG45_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS3508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000313">
        <property type="protein sequence ID" value="CAJ1933896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG45"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042233504" description="Glutathione peroxidase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1933896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35048" checksum="DDA695F8767597F4" modified="2024-05-29" version="1">MMLPKSISLIISLCAISVNAFAPFHADASRSLRLLSTESDFEEGSSVERRSFLSSVAAAGSLLLAESASADDGEESFADIAARASKLSTTQSEIAPTGGAKTMDDKTAYDFELPFKGGNVPFKELIQQEFDEEGRAKIKAILVVNMKEDDPISRNNIPEFISLAAKYGRDGEFAVLLSPSDQGYYEPDTSQLIRLKLASEYGYGINPATVLTDKVIFLGTGSTPFWRWLQKNCRTPAGLGRIEANYEKFLLDGRTGLPLRRYPRLYKPLDIKNDIEALVNGRALPPAGANYLEQWRQAAVAAQADTYRFQKGLNYYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHT5</accession>
    <name>A0AAD2CHT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS1230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHT5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016849">
        <property type="term" value="F:phosphorus-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003193">
        <property type="entry name" value="ADP-ribosyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912:SF7">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02267">
        <property type="entry name" value="Rib_hydrolayse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041968053" description="ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1926590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44298" checksum="105ECB9C3BA7F9F0" modified="2024-05-29" version="1">MNPFKRHQPVTSLLLASALTATILLSTPANAQNNNNNNINNNAGQSLFLKEILSGRCYEKMVNANQCPQVVGSIMSVLDGQSDANIDAITSFAPYFRQVDMSSPNNQALIWLTGNDGSFVGGSTNNNNGYQNGNNNNNMSGGYGGYGNGGGGGYGGYGGYSNQQQQQQQQQQQQSSNFALHREMAPVELVTPEQTPGGFLMHDLVFCGVDRKNDCNKINSNAYSSFWAAAYSQFARTASGRVQIVIEPYADLSFFRTNVIQQLNAYQVTEVILYVQNCQDPTYSQLTDTFPITSVQCNDQYSDYAFFLLCQNPGSGACSMLSQVDTTGAISTQQEAAIEQQEEDQLVLEKKTAEGGSGGGGFFFKFLLFGIACTLVYRYMQKPRGPPQYYQYDNVPPAETTSMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIP3</accession>
    <name>A0AAD2CIP3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS1882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIP3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="334"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="832"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1930262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="956" mass="106497" checksum="13D4A34DE76AA126" modified="2024-05-29" version="1">MEESHFDEDKMINDYVEDYDEPPPDDYDAMMLEEFDATSPASNSSPTNRATQVNETPDDALRDQMITTGIADYRQYEPQDDVESIQEAQNQQRNADAVFSFERYKKGEWRRELLQSKNSANRTRSPTSVIQSAVQLKKMGKATASDAALLDILNTVGASSSPMKLSRSGSITSVLMNPKEGERAYPITIADGTRVFVRERNGEESRAQYSHNQQRSVLTSTSFLGVSINELKRRADIIRLKKGFSQNRLRNRNGVIGDGRLWVDKHAPSAFPHLLSDERTNREVLRALRAWDPYVFGRDPPSRPSSHTQYQRAHQQEENKEKLKNPNDKRPDESSRVILLSGPPGVGKTTLAHIIAHHAGYRPLEVNASDERSSGVLTDHVRRAMESKTIEINSDRQDYGKPNCLILDEIDGADARGAIQALVEIIRAEIPPKGSKGRKPPHLRRPIIFICNNKYSPVLRPLLPYSRQFNVEAPSANRLVGRLKAVLGREKISMMSGAPLLHQLVMSSGGDIRSCLFTLQYASTQAGDGGDISSPLQSALGGAGLKDNRADMVTTLNGIFRKVKTKAAGRLVENSDKFSVRRVLDAVEGLGENSNTMNALFMNIPRVSYIDPTFDRCSTAHELISAADIGNGAASFSRHDNVVAASIHLLCRVELKPDLTYSARDFVDAHYQRETNVGMVQKLIEGLPAKSGSMKCLSYMAQEFIPYAMWMLSAGRDKSSLSRAASSIDMLTKTERVSLDSHVALLQSLGLTYSCDNEEPVMKKDFTTNFQQHQQHKQMVLEPPIDRLVIFKELRVSNYFRRVEIPSGMKEIIAHQVKLESFRHMELPTKAGTVNPTGESDKSAQSQDMEKKEKKDVPVIKVNIRKLDDLAASAPVPKRTKTSPTPTNTKNFLGVGAKRARQMKSARKAAAVGLGSKKNKMAHTGSGLQLNQVIRLRYVKGFTQAVRTPCRREDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ13</accession>
    <name>A0AAD2CJ13_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000473">
        <property type="protein sequence ID" value="CAJ1935453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ13"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="434" mass="48889" checksum="43FAA019693017D1" modified="2024-05-29" version="1">MQISLQNPFSFFDIDEFEKNQNNNQFFEGDKPDPHLCLENPLVGFWLICSEMFDYPWATTFNEASLSIIHGIKQKRVAPFQSFFRPESSYHHIQHAIQKISDPMNDHLDNAVGQSQLNKTTLVDQRKRYRNLTDNRYKALADEDGLSGGNADNAEAEDDDATTIDGDAYQQPNQDDDDHEILVTAVQNNPRRPPLSSDDEDDGDEDDDDNEDDDAVSNSEVVQTESVEALVRSEDDNMAVDSLTSPTQVSQDSSSLIHTPPPTRRLAPSPTLAEKLNKLIQVNLDGMTCRCHIFETTFATNFSGSDSGTVAEAILSAVLTSMEEALNNSFHELKILPISDDTYKQQNRWIRNSVELRNKILSYRALSLYCDMEYGNSPYAATNSKPGEKKLLTQMRVGFARDTSEEAVQDYLHTGLRSQGRGVVTRRRFNMGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJD1</accession>
    <name>A0AAD2CJD1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000491">
        <property type="protein sequence ID" value="CAJ1935650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="306" mass="33351" checksum="6B02EA41FA732D7F" modified="2024-05-29" version="1">MRDVAGAEESQSRTKRYACIAAVVVALFFVLSLSGGSQDAGAEVVGGQAKHHIVNHPKSGGGAAIDPGLDEDAEFSDAQSKFERTVKEQVSMNENMLSEEMGKELEIIEGRLSDLLSESGVDFSEDEITTLKEGIRSQLEDDVHKFINDQADETLEKEKTEFQNDLDRDADDTKAEGEKEAETQKSEILVVLRDKVDEICISAKSQMKSFAAVAEKTILEQKFEEKTSKSYVANISDENTVTSVEKSSDVAAKSTKKGTKKAPTPSPTEAPKTGKKGGKKAPEPESDSESESESDEDEDEEEEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJF6</accession>
    <name>A0AAD2CJF6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000380">
        <property type="protein sequence ID" value="CAJ1934768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJF6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="279"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="601" mass="67592" checksum="028046E98733BAED" modified="2024-05-29" version="1">MADGSTTPNPMVDQSPQGDESMMMEDHVSETSHHGEEEEEEEEVEEDDSNNDDHDFFDHEPSKVEKMEMRKASKRPSEWLKLLCKEWALHNMQVVEATDKLFSDYKPYLKGYLSSQLLCRLSIPPLITKHGANGDTSPPLPMVDFWGILQITDEFDKAYIVAQIERFSALYQIHATTILQDDAPSPDHHHQQHHQLLHQQHHQQHQQHHHHHNNNATIDLPYDDHAAAVAAAAAAQANGSLQLPSYMTEAAAVAVAVSNDVQKLTKKQASEVTKAHRMAKDAEKALELERRQNMKREQKRISLERKEQKAREREAAQMKKAQERMARENSREARRKRKLDLRLEREKFAQEQKEAALKRAAELVSSNRVPIEITRGAAAAKAAANAAMMQQSGSVNHHHHHHHNQVPEMEHHQHHHHVAPTSASAASPTSQPRKRRRSAIVVSTAADLHQIVTHSKNLWAKYNAIAKEHNQKVNWITVAKELGIHVKVREKYARMHSRAEQRGFDWEVNGQMKIKDHPEIFLEPTQAEQKAKMPPPPPDAATTVLINEDTQKEVIRTDEAAVAAAAAVVDATVDAGATAAAVAASLAADPAHLTDNKAVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJJ2</accession>
    <name>A0AAD2CJJ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000534">
        <property type="protein sequence ID" value="CAJ1935969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="164" mass="18878" checksum="52B60527CCE997E1" modified="2024-05-29" version="1" fragment="single">QYYINQGLKKFGDDGKDAVDKELRQMLLRDCFTPEFVKDMTASERKRAQSAMMLLAEKQFEKTIKGRLVYQGNGTREWLSREDTASPTALQGAITTTCVIDAHEGRDIMTMDMPNAFIQTYMPEAKEGEDRIYMKITGMMVQILIDMAPEYRKYVVLENGKRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJN0</accession>
    <name>A0AAD2CJN0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000391">
        <property type="protein sequence ID" value="CAJ1934808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="87" mass="9735" checksum="8D6BBD58F9CB619D" modified="2024-05-29" version="1">MFAVTRHASKFTTQISQGRAAYRSFSSDVVTPRRGAGLMERLSSFFVGAGLTALVTQFYIFQEIKEGNEAMIEKQKDLEKRVAKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJP9</accession>
    <name>A0AAD2CJP9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000173">
        <property type="protein sequence ID" value="CAJ1931706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="217" mass="23127" checksum="CCF5651A0C078BFC" modified="2024-05-29" version="1">MADNPPQGGNDPDPEVVEENQRQPALAGNAEEAAQANQQRRQQANPPVPDLLNNLIAAAAVAANPFNQQGQQHGQNAGQPQGGTNNAANLLGQLLAHPQGMNLLGQLITGATNPNATNPTTHTPQYGAFPSTSGTTPIDIGTSYGIKQYSKAVDSLYSSGEDKFDLQPARLLNFIERIQTRALEAGWTIIFQVQNSARNNATDDFLQLHGKISIEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKK4</accession>
    <name>A0AAD2CKK4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000624">
        <property type="protein sequence ID" value="CAJ1937287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="16521" checksum="3B03D1C013BA25D1" modified="2024-05-29" version="1">MPGFQVFTPSSTRGIQRMEKNVHLNYDLWCGEELPFLHDMVFKQGQAAYVALHGDFNATGVASLLMYGDSFAAISTSEGGAQNCTIFGSTEYDCSVGIEGLLPPISAHPSSSIPSNKRIDPSNTANQTDGSDAAGFAVGLLSPAFMSVLIGFLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL40</accession>
    <name>A0AAD2CL40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000269">
        <property type="protein sequence ID" value="CAJ1933366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05300">
        <property type="entry name" value="2-Hacid_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="143"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1933366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="355" mass="39201" checksum="A6D6487B5A7204DE" modified="2024-05-29" version="1">MSQFWNREDSAKQNFDMTKAVIKQAKILSLSDANDPANDPVHKGDLPEGCSLLKIGSKIEDFDIPALQKEEPNVLFVSHPLSRQPLGELLEALPSIEWVHTRSAGIDFVASEALSEANKRVIISNAKGSFSSTLAEYTMMACAYFAKDLPRLLKQKNNRNWKKYSVLELRGSTLGIIGYGDIGRAAAKLATAYGMKVIALRRNPDRSSEDPYCDTVYGNDKESMNKLFAESDYVLCSAPLTPQTKGMITKEQFDAAKNDCCFINVGRGPIVDEDALTEALKSGKIKGAGLDVFATEPLPESSELWDLDNVLLSPHNMDQTDTFMLEASEFFVEENLPRFLRGEVLLNQVDAAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL91</accession>
    <name>A0AAD2CL91_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1914225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1914225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="405" mass="45012" checksum="8C79DFC9980BB235" modified="2024-05-29" version="1">MVHEGFLAALFAGSAHKLKKLILSRSQVKSASIQAVQKALEHGECQIQHLNLAGVYRDSNITPIAKALEVNTSLKELILSCNSYLLDDGADALANALRVNSTLESINFCDADIDVEMTFSTNGWKLFSKGLKEAKSIQRLDISDNNFTVEGMQYLLDGLRENGSITDITMQDIGVDPEGFDLIGDLIRTRSFKYLNISNMSKSMGIYMAYQGLSDRFLGSVAHSINGNTGMEVLKASHINMEGPNGLTPIISSLANNTTLRELDISGIRQDHLLRELTDSLTSNEHLLKLNLKSIPFSTDEFEYFAESLPKMKSLESILFGELDHTLAIALLNGMKDNDTLKHVDGPLGNESCWRMIDFYLRLNRGGRKSLKLLLPSVLLPRMLSRSTNYPDVLFEILREIQLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL92</accession>
    <name>A0AAD2CL92_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000713">
        <property type="protein sequence ID" value="CAJ1938385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL92"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="136" mass="15459" checksum="E2EE14B0E0205A37" modified="2024-05-29" version="1">MLQRNESVNKLDVQAIIALALDLTTIVLLIMAVKQMEAFAMETLAMAIDNLALVSLILATRIKDSRMMEIVIHQDLQTIIKEDQVATTKTCVVLEIKLRTTDLQETLSEAVFKIIIMLNRISIKKWDALFRMELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLA0</accession>
    <name>A0AAD2CLA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000713">
        <property type="protein sequence ID" value="CAJ1938415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="115" mass="13249" checksum="9EDBBDA36046EBE3" modified="2024-05-29" version="1">MDPKVNDKFARWLNMRYGLIKSCTIVRGKIHRYLGMTFDFLVKGKLKICMNEYVKNMLEDLPIKVNKDSKQETPAGNNLLEAGKGKLVSAEYRQIFHTTVARGLYVSQRARLDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLC6</accession>
    <name>A0AAD2CLC6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS4495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="543"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="586"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="712"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="754"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="796"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1935158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="941" mass="106196" checksum="B1FC3A87CE15F48E" modified="2024-05-29" version="1">MDQLTTGEQQEIVKRLQNQLNFNREHPFGVSLLALDNQYNRRLFPNGPFGTIDVAESDCLHGSCPHYSKQADVKLENARKTPIHILIPAFRDKLCSRTLHYAFTQAENPSRLFIRVIDQVQPRSDLEDDAGCWELYCEKHNRNCKEYGSQVRIVKIDSAQSMGPTYARSKLSAMVHWDYIYRNESDEIDLQPVNEQDFCMNIHSRMNFSKRFDTRLIEMHHRTKNDYGVLSTHVTGMESNDQDGRIVPNMCTVAFTESIHHWGTKQCSFLTRPKLTNAMWGAGLSFQRCHGELVVPTDPFLDNAFDGEEVSRGIRFFTHGYDMYTPDIVLVSHDYSTDAENLVMGVKPRHDEDDSEEEDEEKDLSLGKSAWKWVEEIEKSRLGLAVFGTDRVNMLLGIGSHHNNTEQERKELDLIRNSRFGLGTKRTMDQVREFTGIDLLNKKMECNKCGNNYWVPFEESPNYGVQELLERGNIGKAQRQKTDVVVEEPNREGQREQKIEQFQGLVQGIMGNDGAIQTECTSEFRRLLSIEKNPPIQQVIDAGVVPRFVEFLQRDDSPALQFEAAWALTNIASGTRKHTKLVTEVGAVPIFVRLLTSPNADVREQAVWALGNIAGDSPPYRDFVLQAGAMEPLLQQLHQKSNLSMLRNAIWALSNFCRGKPQPDFEIVRPALPILSQLMFSGDEEVLTDTCWALAYLSGGPNDKIQAVIDAGVVRRLVELLLHPSPSVQRPALCTVGNIATGNETQNQLIINDDVLPNLLALLSSPKTKIRREACWALSNILAGNQEQIQAVIESNIIPPLIQLLTNGEFEIRKEAAWAISNASSGGNSQQIKFLVQQGCIRPLCDLLTVNDPKLVTTLLEGLENILKAGEEEANASNGQNQMAVLISEAEGLKKIEDLRQRSNDDIYEKCIEIMETYFGVKEEEETNSLAPNTREPRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN97</accession>
    <name>A0AAD2CN97_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000929">
        <property type="protein sequence ID" value="CAJ1940659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN97"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="435" mass="47882" checksum="A3FA6F29B3930EB5" modified="2024-05-29" version="1" fragment="single">MTGRSLLPSEVAQGQVGLTAKARSNLTTPSSIDLTKDNPDLTNTKSQRKQPPPPLSSAEDGAVQGRPLVAYNKNLKVSKFHRLYKKAWRKEVFGNQAFITWSSRTAEYSGRAISKCPGWWADVNMDPSSDAQTYDDIAEFILTGLKAYDPSLGGSMPQLRSSMQNLFSLGDLKDADDDEGSWALREYFLRLATQCPTVVFDLGTAQRVSITTDKKSPRFWEFSLVFAPTLIVQRAEPLTWMWLAASEFVAHPWTGPAIIPPIVEEFERLERESKIAKAQSKSKKRPASTPENPKGAKAHDSRPSPSVPMQTELTPPKGRSKPYQQTPPSDATPPRQQVVMSDAVHVIAGTPTGTQEANVPADDVVVANTHHGRTSAENGAEDHNSAPTYRDTVAALPAPTVPLTTDERLMRLLAVHWNASPFRHITIFNVSIVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNZ3</accession>
    <name>A0AAD2CNZ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053019">
        <property type="entry name" value="GATA_zinc_finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353:SF23">
        <property type="entry name" value="PROTEIN HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353">
        <property type="entry name" value="RAB-GAP/TBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="885"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1331"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1796"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1892"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1959"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="447"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1337"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1810"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1828"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1928"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1999"/>
            <end position="2010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2054" mass="219288" checksum="7BA027B0F892F3E8" modified="2024-05-29" version="1">MDKKESSETGLPSKNTGKSTTTPQPAMARSLPNANSQQQLVNPQARTTPDSTPRRTGQHLLSTTAVAKQQLPSSTTTNTNTNTKATNTSSSQPSQNPPQRLPPQMATAAAGLHYQQQQQQQHQQRHQHLPQHHLVQQHMQQHQQAAAFNANAIKGGMPPQTANLARSQSNNSNSNNNNNTGNDRVTVDKAAHKSLVNSSQSMPAHRAAEEAVMRRMRALPPGHTSRLGGKLTYQPRPAHMAPPTAASALTNKGGMMNLPPNNNSNSNAAVAAANMAAANRAAAAAANNPASLVRQPPPNSMMTATAKNLSKKSTSSTTAPPLPGIKAATPPTAINAPIPMPMPSSSAIAAAAAAAQQPPVLDEATLIEEAIRYAREPLAEKYAPYIVPSDKTLVEARSRLKKAIEQTRQLRAAFSERVYGKYRVCLRPPPTTEQILARIQSNPAATHQQLLEEIQTLKAEKEIEKKEAQKLNAEMTVANEQSAEGKAATAAAVNAETAEQLMFVSAGLSLIILPEQDVAGTIDMSGYPDRAPVNPETGQRVRSISVAAAAAGEVMLDRARKGATMRMERQRRRQLQIMAGEDPEKEHPENTYSRLSLLTSTNTSTTAVVAASSSAAGAANNALLGSKVAAAKVLGTTAAAPGVTPSTTSLLHHSTFHYHNSLTPKSFKNHIGSAALQKPKVDNPTAPIISAKAIRARVQATMSNNTLLSLNPTAEEVRPDGKLGPATMAMIELGVTTTTGGSNSNNNNNNNSSKLSAQQQQQQRFRHPFPTSVGAKRRAFLGTPQATNYAVPPIPTAKERRAIRPHPVEDTEHVRTERAKDAIQGVLNQYMVVGPQQQQQQQQKNXXXXXXXXXXXXXXXNKEEQPQASFPPRKRQRTDISFLYGLEYPSSEEATKATTNESSKEKNKEPGIDPMLTFNVLRAVGLIQPSASEDTGGGSSSPLSIIDQSLMDFAEQQSMAMDSSPSHSSVSKLKRLTEKLMLAEQGGKDGKNPNTVLSMFFPKMEQHDVATKDAAEGLDLKDASGSTKENSEESAMDIDSDDKDNATAGNGADGDSTMKTAPTVAIRGGGSELHSTTEAKPPPVAATMNGTKTPEPQQVPEQANPQNGRPTNLPPQAGNPMHAKEMASQQQRIVMMNQQLARADQNFRMGNAGHQNAMAQNGKAGNSGNRNNRMQGLPADGFNRTGAAAMQMAHQFRHASASMQRLSGHPTGDLEAYIGNLHAQQGAAGYEWSQIAALGLNTHRAMVNFSAQDRARAMIAEQQNAAAAAATQVAAAQRQQALAMMGGGFVPAGAPHFAQFSGRTAALMNNSALMGHSGMAGVNQSAQMQANNMDNSNNRKDQGMTKERSDSDSKNSQKDSKSSKPEESGTKRKLSTASSGSGGSDKRRNVTSQSSFKPSDANGTVKAANGVQEGQKKATKAKAQPKSTPRAMNANKTGASAKPGDPKQVGGRPEVPKVNKPPRTSGMQFYVPPAPIGIPSDMASLVLAAKVHSVIDAWENGEAVFDATTIIDFLLAVGIAVPIPKALVVNPLKERIGSTATKNNPFANVPASSRDVVVALILLWLWKHHEQCFQKAFAKSGRIDVDPECKWLINAAVDRSVSSLGKEITSAGSALSAALSLAKGKGGSSQKGTAQANDADRAQGRATRVDLLCASIVSRSLLEGSAIDDTMDKMLPSFHEMLEYLDECRTGSLHSKAQERALLASLISRKATMSLPFSHAYASSMVRAGEAIGHGELFEIVQNEDVKVSTMIPYDVFTDESGAWEDPCRPEGSFTKGLTGDDLMRRAHARAMIQKSLKKLQDRHGIKGGTPNSGAYTDPPTSTSNADSGKSPSGPGSSSGRGKRRNSFSEPKFPPGTGSAHATSMALYEPKHHSSPLEWDCDAPENLPYGIFSSKKSAGSVKRRTSQGAADSGGKSPRGGNVVVRSESVGSASETAPTYPRSTHAISWNDIASVFESQNVQLPIKKKKKQTEEKSISKNKTIYAPFVRQTDSIPSGSESESESDTEEDISDSMVLSRHQEVLDDMKEKLSDFLESRKKSVERKKKKDNLKKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP53</accession>
    <name>A0AAD2CP53_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000987">
        <property type="protein sequence ID" value="CAJ1940962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP53"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="143" mass="16506" checksum="433A5BFB305DE122" modified="2024-05-29" version="1">MLVTLDSAAAAKKIDHLGMSPFHILTSSANLREDIFKYILSGLDYLEAHQCCWQKDYQGKTCIDYLLEQPRRSNEVSNSMIQMILKKSVQDRLLGWGLESWRLEMSGTIDRICTNEDADANKELVDELYKKCLSMRSMRTYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP67</accession>
    <name>A0AAD2CP67_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP67"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="452" mass="48841" checksum="D91870C5CD49E281" modified="2024-05-29" version="1">MKFSAITLAVFAVSGFQNGLFGPTCAFQQHASIVSKPRPKKSMATRESDLAAHSHHSQEGAPVCFINNEEPLIPLSNIGKNNDFGRHLRQMGAGVVAATAVSFAAVTSDSSQLSSTVANAAELNLSKGAIVIQLTAPTTTKESDGESTQSTAKGQFKKFDASQEQKLLQTLLKNRKELGASIGRIQQSIQNELQLKDSTTAGPTAAPIWTEIYQELLSIEGDVVPKVQITPPVDLAATVRDLRNGQLNLLVDGEIINVSVEPTFGKDEDDLIIRIKGFKGGMIPKATKEAPPPTAYYGPIRSWLSRFDGFWSFWDSPTALFGTDGPGFLSEISNGEVVISGATSAIVLSYVVAYSYYLQQIEEEAAEAAAKQAAIAEKAKQKKAKVVKAAAVKETASTKESKQTKADVLKSLGKDQASEEEESSPPPPTSKPKKSTRRHRFRFWKNRQTESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPA6</accession>
    <name>A0AAD2CPA6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000788">
        <property type="protein sequence ID" value="CAJ1939402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="134" mass="14536" checksum="E2D4DCBB71D2F426" modified="2024-05-29" version="1">MPELNVRFQGARRYASEPSHPSCPWWTAPLPSDLLCATVRPITGSDSVLLTDTGRASEPSPPNSPSILQAWQTVAELCTDYYGWVPDEIEVHGEEATLADALLEGRLRVISDGPFKNELGTAAVQLLVKHGGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPD3</accession>
    <name>A0AAD2CPD3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001057">
        <property type="protein sequence ID" value="CAJ1941684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPD3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="155" mass="17693" checksum="2B0DD1F86195A716" modified="2024-05-29" version="1">MKWMIDASFAVHPDFKRHSGGTLSFGGGAAQVMSKKQKLNSRSSTEADLIAVDDVVTMILWTKLFMEWQGYPIEKNILYHHNKSAILLEENGRKSAGKRSRAINIRYFFITDQVEKGNVKIEYCPTDNMIADFMTKPLQGEKFCKFRDLILGPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR12</accession>
    <name>A0AAD2CR12_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR12"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="309" mass="35435" checksum="7E637F4105B56C28" modified="2024-05-29" version="1">MLWQRPPEPAVRAVSTLAQVCGVERIKEAKTIADAAIGSQLHQSRSLVHHTADGNLLRMTEELREWADPMSKDGNGKSALQMAIINGHQDALELLISFRALPNIDEMCDAIKYNREDFWEILLEECDLSVLDLGTLVKAAHETGLQSVQAWLHRLNQYDYFDLSKLGLQTPFNGIYIIQNAYHGESHYISFTQHEKRLRATYAESDAMPLEFFPTGEPDTYKLYNQWPGEKKWVSFSTDGKWLYARYADESEAMPVKFVATSTAMVYKMVNMWGGQENKWISFTNDGRWLRATYAKEHDAMPVRLSFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR39</accession>
    <name>A0AAD2CR39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS7044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="6">
        <location>
            <begin position="153"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1940442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="84093" checksum="298A7B5E982B26DA" modified="2024-05-29" version="1">MGIKGLHKGLSFCTEKGNMTQFQGRRIAIDTSSWLHKSVYSVSETYVESTERNCVDPKCILVSSRYIRKRCEELLKVFKVAEIFLVMDGKRCPLKVNESAEREHRRQQNLREARVYKRNGRNDKAEEKYKMCIKIKDELTHEVMAEVSKAFGGSRKVSVIWSPYEADAQLAKLCVDQMADAVVTEDSDVLVYSVAARVAFPVIFKLDRTSGVCDIISMAWLLDPPKVQQIGKARSALEGLLLNFASRESKRPGFGARLFVQGCVLAGCDYAHSLPGMGLVSSMKSCRNHSFRNEEVRFKKILESLPKKSKQNIDIDAYEATLAKSEAVFYYHVVLHTNGHKKHIAVPRLSNEGSGTGHCATDHSPLLGRFGDELNFLGEIDTSRLQSARNAMPPQHASSDNRKPLQPSNSSKKPISKWFQPVTKMKNPYSSDANSTNLFLKSNHKTNTLTSNIQRCNELPDTRYAKRVFPTFTADTSNHGQRNQQNLLSSTERKVGKSAQCSAGAFEYGADEDDSGSVCVLDLMAADNGKKEAVVFGTDDAYRIDEIHDENDCIIVSRVEKQAGTKTLSDTSECTIHNQEQHKDYISDLGDSDFSPPLTVHASSEADEVLTESRFFAKSSARRITLEPADVKDTQKYEMTGQNRLDLQGRKRRKNSRSIASSRESTDSFLDDVVDSPSVEDCVQQRPYKVGRKLGAPKTFGAIEAGFAKQRKRSSFEGVCAGKKVEILRPSASKSRGQVDCYFKPRSLYIANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT87</accession>
    <name>A0AAD2CT87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002258">
        <property type="entry name" value="PRK01192.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12782" checksum="8141C4D4DF6C9F61" modified="2024-05-29" version="1">MVKTDLVTRDYTIQLSKRIKGQQFKRRAPRAIKEIKKFAQKAMGTSDVRVDSNLNKKVWATGMKNPPTRIRVRLSRKRNEDEDADESLYTLAQLVEVSSFKGLQTENVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUK7</accession>
    <name>A0AAD2CUK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="364" mass="41704" checksum="FC7EFC0620C496C2" modified="2024-05-29" version="1">MTKRSSLIRDLEVDCVPAFERDEIIPFLGDKLGKGGFNTVYELEKINLDEQSPCNEAQRQQRGLVVRNVSKKLAVKFLNESAMGNSNEFCNGAADLLLEAKYLSALSNHPHPSIINLHGVAAAGAAGFATGQMGGYFLIVDRLYDTLDKRIELWKELRRRKLRHSSESNVKLLQAMFLQRITVACDICSAIRHLHRLKIVFRDLKPDNVGFDFDGRVKLFDFGLAKELDPLQKTPEGDYEMSGGTGSRRFMAPEVSLGEPYHLSADIYSFAILFWELCALEKAFGRMSQEEHKERAIYNDDRPPIKKEWKPEISALLQKCWKRNPRERIDAADLYQKLRHEVNLYYEEGFEEVEELGQERKLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVA5</accession>
    <name>A0AAD2CVA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="5 14">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS9767</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="5 14"/>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000006">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF23">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041968555" description="Phosphoglycerate kinase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="394"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1945623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="438" mass="46323" checksum="7F2C833D87032863" modified="2024-05-29" version="1">MKFTKALFFLLAGTASTSAFAPAHSFGRVAVPSPFELEAKKSIEDLTEAELKGKKVLVRCDVNVPLDGKKITDDTRIRSSIPTIEFLKSKGAIVTVCSHLGRPKDGPEDKFSLGPCADRMGELLGQTVTLAPDCIGDAVKKIVDEAKEGDVIMLENTRFYKEETKNEAGFVEKLAAPFDLYVNDAFGTAHRAHASTEGVTKFLQPSVSGFLLAKELEYLDGAVNNGKTPMAAIVGGSKVSSKITVLEALLDKCDIIIIGGGMVFTFLKAKGLSVGTSLVEDDYVQTAKDVLAKAEKLGKKILLPCDIIVADKFAEDAETQVVAVDAIPDGWMGLDNGPETTKEQKEALSDCKTIIMNGPMGVFEFEKFAAGTFGIVNILADLTKEKGAITVIGGGDSVAATELSGRAGDMSHISTGGGASLELLEGKILPGVAALNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVS3</accession>
    <name>A0AAD2CVS3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVS3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="198" mass="22358" checksum="4F9EF5406153A3AD" modified="2024-05-29" version="1">MQTTLKTKIFEHNNAFYTTDFSESSDYYDEASSRSLASQDPTTTSTVPPTTSPFRIGDFITSPISPGRNIDRMMMQQTKITKYDNRRTLLQRFKSISRKRKVNMSKDEEPLLVALPLEDNHSVVPDEKGGQATPGGSSQQEQQEDEEKPLSVLALPLEEEDNNHRIVPLEKPPAPAASPATPWEKYSKKNYFRGVFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVS7</accession>
    <name>A0AAD2CVS7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000700">
        <property type="protein sequence ID" value="CAJ1938277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVS7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="362" mass="42549" checksum="A7D2E2ED2D5C41E4" modified="2024-05-29" version="1">MEGLEYPQIMISSIKELNEPDWDGLKPKLDLAGQEDKIEREAKKEELKTESVEYHRQKRYWSKAKWHVHSLIMESFVTSKMKDKILQEVDYNEKIEGDPIELLRRINKFMTTSDVTDWEPITLWEALQKWVNCRQKGNETVIEYRKRFEECATTVLSFMGDSWLDVFASKTTAYHEIENNHPTNGLSDREKKRVAAEVEALQEEFQEEFVKLFCAAGLLHNCDRARYQPVLDHFVTAYAVEHVDYAQRDLFPRDVETAAKALHNHWVKKTTTPKHNNNNNTNEKRTHHRTVLTLHRITTRGVSVNVFAVVWRIMLHRDVNIDSDPRNNGKIRQNGDRIPGMNRDANRYTCRQAPRRDLCSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FAS0</accession>
    <name>A0AAD2FAS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chorein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1900951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Chorein N-terminal" evidence="4">
        <location>
            <begin position="244"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1445"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2329"/>
            <end position="2352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1196"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1455"/>
            <end position="1464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1900951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2806" mass="306717" checksum="83856DF11282B268" modified="2024-05-29" version="1">MAKKALQQVLEDTIGKYVKGLEAESLNVAIWSGKIALNSVELNVDAVNLELDRQAEEAPNLALPFKVVSGGFESFHVEVPWSHLASSPVILRLSGLSIIVEPYNRDSQARNESVSIAHAQKERQSSIKSSNDYREQANAVKKLAEAESDSSNQSSGSFVSRLVRRIIENIQVEISDVHISLAGKEGSAGVVLESLSLVTTDKDGKRTFVDRTITSNAENLFLHKALELKGFGVYVDESIPGEPQPHSYIISPLSFQANLRQADGNICIDHSKYHLSSELSTVSIEVSHNQLDVVDKVSQSIATRGNRANPLFPEYRPAARVSSKNAHEWWKYAKRCIGRMSGRSSWAEFFRAFKKRKTYIQLYKRHAHSETCSWIEPLSVSEYSVLTDMENDRTISVNGLMVWRDLADGQVDLERSKRTKNEKGKKKGLFAVFSSERNEDNNDAPLQLTIEELKELEDMSQQGFLDDELSKDSRLCDASFILKSLNIVLTSYQSRQIAALQMGEVDLGFNARADGAFAFNFDMYNLKIQDLATAVSLFPNVLRSLPKDNLVTTEEKKGAVHLQIDKSSTGDQSLKLNIAAFEAVASPTFFKELIKFATLTPAATTEQVKSASLQSASGSVDDISNALVDAWKAKTETKISWAMDVDIDAPIIMVPEACNNTKARILVLDLGHFHLTFGQFSPNKQVEQWFQDNKADHKVDVSYEHGFLGTSDFCFKVGTASDWLERSNFKGFNSGSNIIEPISVKLDFGIEQSHNAIDPPRICCIGVVPFISFRFSPMQGKKLFPVVKAWLDFANEMNSKSEAALPIEAGSSVPVAADGGFQTQSIAKVEPEQGDTVQVPSLEDQSKTDEEYLATFFFKVGLQRLSTTLSLDENNRLEAHLVSVYASTVVRSNGSSSTSLQMGWFWVLDLLESDIRRKQRLLAHSKLTKDPSSFAEGDKYDMLGHLVEQGVFEEDYAGSTDLADISYDQLVSEYGKSRMETRVDQLLDMKFCSLFIHWNPKGLEGVLSMIDSFRSIVDGDETIDRETVVEVVSQNISSPSADAKEEGDSTVEGKLLIKLKAESFDICLRSPRDDLPLFVLAVLDGNINVISGQNELSCHVTLKSITVEDVRPESSHRQYRRIIGQGTGTSATSGSDSHLFVIDYVAELDSTRAELVIGSPQIILIPDAVSELVTFFRVEDQKKQGPSPSSAELEDEHDRKESVDSMKESLCVNEAGNIEVLDGIKYEPSPSLTKLDDENGKKDNVDGTESICVNEAGNIEVVDGTVSYRTRRQTYAVKTQVCSIVLVDLGSELSSARETEARQPSKLAETVVLQGIFDVTVTMDADPENSEMINAGVQGQAEAMQIFSALGKEMLSPMQILAPTQSSLHVSMHKNADESTEIELRVAATTDLEVFLSMHNAAMLSSIIESLSSSFEAKETRNGKSQIQELSAIETERIEQLSSVLDQKDNKKPTQHQSNSSVSTDEAPFQLQPDVEVKIAQKIQTKITMPQFRVTVVNDLLGLDEALFRVSVAKFVAVGEVAFPIGPNPMQNMSVDFRMSTSILADYFDSSINLWSSLLIEPWEVSLKASRASTRRFKSPRLSSTIDLESFPCHLSLSPEFLVSLASAQRMWSVYSVATSKSPIAGGPKDDTNDENAKASMVASAARNLLTSLPYAIENHCGCDVIFSLPHGRIKQRECPTGSIKYFRFQPPQGRGHGGRRVYGQDVEFEKSVTLSIGDCEIVIPHLDGMLGSRKEVHNLSDGRVLVTYVIREDKTTVLHLTSNVSVFNHSSIPFAISVGMIDPQSIGTCVAHNEQKTITALTAIDGVASEQSNRCSVPMDFLTTFSKEWADTSQSSLFLRLSPNLKSDTSVVLSGLLDIASQFGELSHSGKVWRVDVFCQVTNGGSGNIDPFVVQVLVKGTLIDDKSINIDVFLEPRAVIENLFPIDISLRTKMPYTFSTAAQESGAGEHDLKPMNRVEVFTKGDSIAIAMKPTDTASAGSTLEWIDLDLPLKSDFRLSEAVACHFPFAGSKKRNSEFFIAEGYEGLDQLSEVMADEVPKESGSKSSVRKVSLEDPLRSFHVTVCCYGVDHTGEILFESVESMNDRKQYHPFGAFSSGKDSIRLTMLPRSNVMLRLLQLTMEKQAGYKATLPFTMNDLVIGEGGVNALPILWENKKSSGYCAYRRLVNEHQSEIHIVPEFVVFNGSGEAVIISEQGMEDIRIEAGSFAPLKCVSRAGGLELALSYATEECKTKKVRVDQLGMKMELVHSTAGTPVGSVCVQTALDSSGNARLVVKIGDITAGAKGAKAANSSFILPAFLADDFVRFRVRWAKLQIILNESREKRIGEGLSAQDLSSPNHTGKKGPKPVQSDSVMSVNFSQFSVDVQRVFKQQQGGDIKSKTSALPSPERCQISMIIHQLQVKDLTPNSPFPIVFDSSSDANFIDVCARTRGPMDADIVNVDLFDLSLAHSKGKSEVIQLTTSEEYVWRIVDMITRITEASSEVGNYSLVLTEDRDHGGFVVEIKDGVDEIDERVMYTPPRVDQLYELDLARVSPFTLLVSFRRTPDESRYEMARNVRGAALTNYFTRKLKFSIDKAKLKFGKYENRSIKGPPDRLLESLGAVYVGRMKFKVLALLSSASLQDWQFLAARDGDDAYVEGDELRATGNIAGMAAGALLGTVGRGLGDGVSNVTRTLGNGIEGATGLVGARKLGAGVNTVISGVGGGVGNTLTGVGGGAGKVLHGAGQGVGQVVGGVLGGAFQMGKGIGEGIVKGDGKTLVDGIGKGAGQIGGGVVKGTGSILKGATDGVLTVGKGLFQFGKKKPDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC56</accession>
    <name>A0AAD2FC56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC56"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39116" checksum="B8ABA49A6C781BF8" modified="2024-05-29" version="1">MTSKKVKPLASLFQQWSSQQQRESSSAQENVPQSSYRILIQSTHGLATRIQAAEAVENPQVYQRAGVPTPAETAIRDSQGGYAWLEHLVELAQKHNHLIWVATKSQPSPITNKLISLSNDENANVTVVNVAVDPWGWDDEFKKGSPSLHNLHQLYDQLSNVMQQQESSAVLAWESLTPLIAVHGFEMARQFLTSFESCMQIWPIRIELLTPFQHSTLEDDAQALLHLKGGEMTMIRQGLRERGNILRKMLPFRLDGGKLVELEAGDSSPEPDEEVMDKTSAAEKTSSSSAPVPVADTSSRKIQLKMEEDDEPKKEESSQPNRPRIYLQDDDPEFDDMDEEDPDDDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FD99</accession>
    <name>A0AAD2FD99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000080">
        <property type="protein sequence ID" value="CAJ1929336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FD99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="176"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="251"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="349" mass="39851" checksum="850C90F88F697B07" modified="2024-05-29" version="1">MVNAQYEAPVALLNENKQYQTHCDFDEADSLLLGLEKSMKTDKHLAAPEAVGSSMYYNLDGCISKAGDIFESYPMAPPMAPPSTKDTSVSSHDLSLFMDQVMRPTLPTLPQPRPFDLNLSIELEPHPQNDKKRFLEEPTFLNTEPPASKRSRICNVVEDDESSQEEESLPKFRNYQEQQWQEQYQGLLEFKAKHGHCCVPNSYPPNPVLGRWVKRQRYQYKLRESGKQSTLVAPRVQALEAAGFVWDSHSALWEERLNELKQYRIAHGDCNVPSSYPKSKQLSTWVKCQRRQYRLFGKGKNSNLTEERIAALDDLGFVWDGRTIGNRCSKAAACESTRPRSTRFLNANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDA7</accession>
    <name>A0AAD2FDA7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000240">
        <property type="protein sequence ID" value="CAJ1933100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1933100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="305" mass="33304" checksum="22DC4D84FD478B93" modified="2024-05-29" version="1" fragment="single">MLSPKTQITFRSSLRRLQQPTMKSSIVAILLIIHAGSIGVLGSRMKGKIIRGDDHQNRDLQTFPLRKEVPYSYRLKQRWKLAGQAESLIMPSIPGAPTHSPSGSTKAKNPAQGFFTLAKSPTITAPSVFPPQTPFPSYSPTKSPTKWPTSYPAPVPTLNPTPEPTKAPTKPPTPSPTKPPTKPPTPSPTKPPTRRPTQQPVRVPTNTLSFVGDNDTNRNGFPLTMCEGDCDSDSDCMGNLICMQRSGTQPVPGCNGSGDSGKDYCMDPSLTQAPTDKPTMPPQSNSGSFMLRLYWQSSYFWQETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEV6</accession>
    <name>A0AAD2FEV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000291">
        <property type="protein sequence ID" value="CAJ1933700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="344" mass="39153" checksum="435AAE333019EBC5" modified="2024-05-29" version="1">MHDEPLYMSNTRRGQRWVVFVVLLTILARGLWDVGNLQPDSLATNDRLSLVTISSARISSTNNSSDNGMLAAQGSKSSHHQSSCPSGNNMKHFDAMYIMYMPQRREYIEQVVEYYGFAHCFDIIYVPAINKSSIDKQWFQNKGFVASPFKLGIGKIANHLTLLKTLRLFLYNSENGDDSFSNNNNNNNNEDHSWMESRCIILEDDIATLASSEQLSGWWRHFSKVVGDMKRLDWDYVNFGRCYASCKNDNHVMNDIVHYNQAACTHAVGYSYAGALKAMQTYLPLRDRSNDLMIADQITSGKFDGKAYQITPILFKQNETMKSLLTDHGKSWEKPECSDTVNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGZ1</accession>
    <name>A0AAD2FGZ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1930961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGZ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="589" mass="65664" checksum="D3406FFD54D0F1ED" modified="2024-05-29" version="1">MEHWASQFVEPTIRTNNDNTKPWNKDMSYLRASPPKQIRAPATEQRDEPAAYDVPNDIPSLSQSTSSLSLSVTDVDRERTTPTDITDNEILQGAAMLKAQLLKEQEELIQQEARYMASPQSTPGRSREYNNSAYFSDTEDEDEQDDYNVWGIEKATPSHFSFVDVNNDGKWAEFSNQDNVFTKTPQGHFSSNESRASKLSSSPDAYIDRPPKRSINLGEKKLPQQSIMNDIPSIESHRTTASKEPGVADAAYAMFMSGTPMSSYAPPRTNTQTSPSRVNTSSTSKPQSPPKSYPLSRNQSAISAAESDALDFLASQFSTEVEPVAPIRKKTESPIKPKQAKKVKKKEPGFPLVVKPMPMPGDLAQSVVSPFTKEYRLLLKDPGYLHAQGAGTLWQSLVSQHVKFPSKWFNGSRAPPMGLGERRLWQYIGRHRVGGDKALNLIVNNRGAAGRILMHIVVKEESTLAPALDVAIGCFHPNARGVRTTAAFEPILEDCRDIWLATRRRFPDDLDVENSLRYQQEKNATLGDSPLGPKHAVNNTNMRAIFGEKPPLQTIFVLESELKKILIDQVATQDMPPSLVLLQRYLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH83</accession>
    <name>A0AAD2FH83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000689">
        <property type="protein sequence ID" value="CAJ1938207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH83"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="220"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="307" mass="34351" checksum="F0BB2FECF852030C" modified="2024-05-29" version="1">MYSIPELIGGASAESYCRVAYYVYFNILISIPEVQMKGLVYVLYDISKKEKQPTMPHINLTMASIDMILSLPIRFSATHYCLKARQEKLGPFNSVLKIVFKVVGDYSYCKVRSRLHYGSDTELQYQLRSHGINVDSIPIDAEGTLREDIRNDWFYEHLAGMGRSSIVPDASAHSLVSAGGSKGAIAVNHDPEALVGNAVAHGASGNNVEKYSPIIPTDGDILLGRGRLVQYNPGNIHFRGLVSKYRDAYDTAPGSRRKEIVSEVSRIISSEGRRFLKQIDSGVWVKSNDKETNTKIAQLFREFRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHJ2</accession>
    <name>A0AAD2FHJ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000802">
        <property type="protein sequence ID" value="CAJ1939508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042000463" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="950"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1939508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1117" mass="120660" checksum="6A252587EC39D68C" modified="2024-05-29" version="1">MTKSSHYAATTMLMFLMALLSLSAQAQPDDIFHCRDPKEVDKKTQLKCEKDSFEWKLDDLEADQPPEICGPAYIAVGQPQTMPAPGETPDELEPCLLWSIFYGSLVTDVPTISPTSLASATPSAPTDPPTTEDGEDGGIFNPPTLAPVDGADTIAPVVPTMAPTLAPVVPTNPPTGLPSASPTVTDPTRLRVEAFTLTYAFNRNLDFNIFNGPDRLELYDITLQHFETSLRAELNGVPIDKIELNMQTAITAGGPLTSPAQQQGSPGGGGGKTWTELVSGFVQFGIPAPIESSTLQTLVSGTFSGNALDVYEFRLQLANDDILKQIAKVSMGLEGIDASNDDNEDAIDGGGGTTNSDDGLTWSPLLIAIVACVVIGVIMACVFAYFLLYGRRRRRRSRQAKAQEEYVTRDIPELQTDPTPPSDDAGLEYSAEDYQKQNDFEQQQEHIEQPRYPSTLPTPDGVMIDADHNLHEPYLLNPVESDAGSSLRNDGDTFYDMENQSLAPSLYSYREEMSILPGGDKQQQAPAAVAPPYTTLDSVPTQLSSLEQPVSERGSPSKKSNTSAAVAGGLLGGIVGKYIGNNKKKNQSALGGDDASSSEDEYGFEKEANPSNDDASLLKNVDDASLLKVDTANSNQSVTGNSTSPSYIMDDRSLISDGRVGQILGDVHSIQGQESTQNFDDIWNDDDSDDDDGIKSSKSTITDPDGTEQNVHDVLNSSGSSKPFDEPKEGATTERPFDEERIEQRDIVIPDIPARNMALVNSQQETARFSNNSNSDRNNNQMLGPLDDDEVSQLGDEVDLLPPELLVRDDEELVEPEPPVVEDPAVKNIKASPFAENETVAEKAPVEDESVEDYDHHHKIPDDSTYEGSSMLTEERSIAEDSYGFVDQKFYKPSVPTKPVSTSSEDVKLALPQNLKQERGVVDSVPNGDVVLASSGSGDDQSIEAVSVGAVSTEATPVAATPVEPADKGTKKSGLTSNIKSLASKPRQLVKGMSVRKKKNSDWTMPSKEERPPRSVSPTPSQGSTDSAKFRALMNEPNVFDTPNSTPDQTTPKEAVEDTKRTTPAPLLQRMPSDSDEDDCYLDEPVIPYPAGVLPKTSYEEKKDDGSVEFSLDEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ50</accession>
    <name>A0AAD2FJ50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042065916" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1944463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1059" mass="117525" checksum="BBB2AED464572318" modified="2024-05-29" version="1">MPVEKLNRAFSHGIFFCLICLLLLVESFGQSLSRQFNKCDPNSNSCIQCWKADVIEGSAPKEASNMTEASCISPDMTFEISKGSTNKIYDWSGNPNGWLIHDRDEFKIMVKASVDWIDSSQFSRLAFEVQLCNIDNIMLCQPVLAPTTFFDEDITAIDEIQNLRTTQTPSVTRFVDLGSVASDTVEEELNFAEVTVPGTYRILTSLVLSNASSVSGVTMISNIKYLNVVHNDPMELSSESYTAIIVMSSVASTVILFLFFQTFAYRNAQVFELTQGKFIMAMQICALVATSSLIFFTPKDPFCQLSPLIYLSTHMVYAILLGRMWRIRAVISPLLLLTLERKDDFTTTIVDLISRLTACACWQGRQQKKIRMQITDYQLARVIMLLILPQLLVQLLILIVYYGNKSILLDVERDGLIDGVYICEYGAFYSTLHIIAVSLIGLEFFLLALLMWSSRELPSLFNETKKVWQILRATFIFVLCGTLLIAATIDHYNTAQVRVLVPAFVLGLNMCQTCWVITWSKLRVAWRGKKILVTKLIADHNFNRGKNEAMGMGSTKYFSHDANCGNKFSGYQTPAVKTDQTPAVKTETHEYYNTADVEQEPSIDIFKNDDQTENVASDDRSTDSSVFLAESQETLLDLEESEENENEGVAPGSSDASIPTGDAPSRAGTHRRKNHFSPLSSFTLFRRERRDKRGSNASRTNSVGPRGSIAIRGSTVSRGSMVVRRRLVGRGGLASSTIPAQADDGNKNRFSVFGNASMPAAVIVESIDTNPRLSQDKIRISEAEAPGRRLLLRMIDVQRMLANVNTSLLTGVSLGRDDWEELRVGCVTLGEVFENEVVFAWDDEDTGSVQTPQSLSQSHTSLPSRLQRHRPGNEPGKNRPLHSSMPPKSKVTSMTNAGPNRRSVAFKTTENIKNEEQDEFVESMLNKPLQTIMSIGSPIVQQKDETLAGGSESSTSDEIHELKDATANDTGLHGEQQQNPDGRNENLAKHRVRANHQNVSLPVELPIIEKLPVGVFGKGAILSRQVSGLSESSEQEKSDATSEGATDVATDQIPLGEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJN0</accession>
    <name>A0AAD2FJN0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001114">
        <property type="protein sequence ID" value="CAJ1943712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="14350" checksum="5DE0669D022CCE64" modified="2024-05-29" version="1">MDPKVNDKFAEWLNMRYGSIQACKIVRGKIQRYLGMTLDFSVKGKLKIRMDDYVKNMLEDFPIKFNKDSKQEAPAGNNLLEAGKGKLLSAEYRQIFHTTVARGLYISKRARLDIHPTITILASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJV6</accession>
    <name>A0AAD2FJV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="251" mass="28596" checksum="DF39139C4B606413" modified="2024-05-29" version="1">MAPKDRQVSIYDTYSNCENECGSGSLSSRYGRKINRVSFHPTVDFHHIVNRDDYSSEETNACFYSLEEKELMCESCEMAVNRMEAGKRPKKDTSYRGLENFIEANATQFDDTIHAYIDAVMDEQERQWDNDMFDGELLREVGLGVSLHSASLAHKMAAYDENEARKAYISMGKAHRKLQDDVSISTEITEVSRSTMVHDIKIRHNKTSRTETKKSSSRPPKSRSSRSQKTIGGPLESLRNKVHDTKTVLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM05</accession>
    <name>A0AAD2FM05_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001133">
        <property type="protein sequence ID" value="CAJ1943780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="75" mass="8781" checksum="F6374E87869139DA" modified="2024-05-29" version="1" fragment="single">FDKKRDLETFQDGNQIAGVDDTEQGYLEEAFDQDYEPEDEDERDFNLHGQFDDIDDSKRNELLADADNDVVYITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMH7</accession>
    <name>A0AAD2FMH7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001546">
        <property type="protein sequence ID" value="CAJ1945852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMH7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="274" mass="31369" checksum="F21EA927358C4DFC" modified="2024-05-29" version="1">MAAGKNPRAGEQGSIEAGFRSVDGSRSRSRCSTKDSKAILEAQHNLCFQQIGNEMKADYEVYDATMIAHCMMQIKAKFDTDEGLNFIQQYYRNQGQKKFGDDGKDAVNKELRQMLLRDRFTPKFVKDKSASERKKAQSAMMLLAEKQFEKMIKGRLVFQGDGTREWLSREDTASPTALQEAITTTCVIDAHKGRDIMTMDVPNAFIQTYMPEAKEGEDRIYMKITAMMVQILIDMAPEYRKYVVLENENRAIYVRVLCAIYGMLQSSLLFYNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNH4</accession>
    <name>A0AAD2FNH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="252" mass="27619" checksum="7E60C9DFEE714C78" modified="2024-05-29" version="1">MMDNRDESRNTVTASSTAGNANALSIFMKDLQISPSFRIVMDNPRTRSSPQMLFSKSKSEGKGSTRWHATTDKVDITSMVSLSSGSSISKTSTSSNSSNPSGSGKNKKLRRKLKSSVKNKSNNFEDEEEPSRAPPRSSSFDASSIACQRRNNPLNRSYSDHLTPTKHNNTPHAPTLPKRRLSRDLDKAPQMVVRKVGAAPNVSTANARIPRRRNTSRSPTRHDATNTNSSSSSSRSPSRTTKDLLLDQVIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNP7</accession>
    <name>A0AAD2FNP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001732">
        <property type="protein sequence ID" value="CAJ1947567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNP7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="326" mass="37175" checksum="BF0A72EB7D71213C" modified="2024-05-29" version="1">MANHLIAPNPRFFTELAAMYVADTKQSRLHPRFIQECVTLPALRSRWRDKGTISAEAESKIAWDTLGRAMQSPPAGLQRWSTKHCVGMCGTGKFQVLWGLETSAACPRCGNFEDVPRCRAALATAEWDRCTAAFSAWLDLQLTGPSIKTAILQLLQGVLTPPSFPPRTISSSVWPAFLAQQVIGSQGLLEGRIASSWLPLQQQHYDKIRCRRSVSLWASRLSQQLISIGFYMWEQQNSIQHSDDNVQLRERHSIVNEGIHSQFDMGPDDLPKEMRPMLTSRRRVLCKPLVVDKEEWLKLLRQEQRDFRRSMKAQRRSLRTIFSFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2024-10-02" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNV6</accession>
    <name>A0AAD2FNV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="191" mass="21169" checksum="9C539B6C5BA50A05" modified="2024-05-29" version="1">MMPSLSTEIEFTHLCRGNGLLNVAAAQPLREQFARYVMGMALDCALFGPCDVDDRQAIRQRCQVGAWLERARQCYPPALGYHGPPDHFAYLSVLCPPEDGWPWPEFSTWLSDLPFDALPDRYQRFEPKAIPVKARAVFVPAILVEKEDPDSDLDAYANVFATTAPTVTATPNIATVPAPAPXXXNNTSFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPL3</accession>
    <name>A0AAD2FPL3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001750">
        <property type="protein sequence ID" value="CAJ1948693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPL3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="250" mass="28892" checksum="CD0F63933A6E513E" modified="2024-05-29" version="1">MDIANIQVEIAESNQKLKNCEKELIECKEKLNECKEKLKECLEAQNNSNNDEYFQNEESTYRRLKDLSPEKRLQTLQDEEKNVSARFTALEQTRAALEQTRAVLQGERLLVLQRSASNSEQGLFMNTEARHKSDQEMDSNLRFTRSGASSRLSYKGKDAIVGLCCPRDQKPSIELKDIEGYEDLWKQAEGDGLEFDEDGAMDDATRRRVKEALRKKFPHSFEQRYFGVSVEFLVQKHVRSLDGVGEMFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ27</accession>
    <name>A0AAD2FQ27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS11816</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1948883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042000907" description="Ionotropic glutamate receptor C-terminal domain-containing protein" evidence="13">
        <location>
            <begin position="22"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="207"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="605"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="621"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="638"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1948883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="680" mass="75199" checksum="DC4561C1CDBF85FC" modified="2024-05-29" version="1">MKSLQCVLALLFFLTIQKVESNIEWSGNWEGRTNWTEIPDGAFVGPGVGSAQGADFCDVVRDNSIALNDALRGRNLSIASQYGPGFDFFQYDPDKPLSETNPTGMIANVLDELASRAGFSWRSSFVAYNATSADLLVGAGTGKWDRMLKETTRFFDVAVDKWRLTTERLENETVFLHSWFDASLILVDTGDKPEINWFGFADPFGARVWLAIAGTVLSSAIIMIVIESLENRRDGRTMKSWFSDHLYLTTLAFAQQFLFINPTSAAGRVFLASFAFWATLIGATYTANLASLLVENALSSPIQSIESAMDAKLSICIHEGSASETIMETSYPFFKGYPNLVKTKTVPELYERLAEGSCEILVGTRQEYEIFRREEKYGCNLVQAGVELLGGSASFAIEFDPLNCDSVLAHVLNIHLNEMTVDGNMTIFWDDYLNSRNGMCGQISGRRMTEIDDVYGPPRSEPMVSRQLGGAAKTSAASSSSFSEEVPTDTSLTITGMAGVFAVHAVGTGIAILIALYTHFRKTYMQKQQARQKEVFGSDSSKVAKYELDEKYDALKMDMLALVAQMDRFFEEHRETGMHRKSEVQMRSIIEERQSMVLARSSMMMAPSTPNNGRKGGLFDNISSRGSNTPNNTTREVASGHDSDNLESLRLDPLDVSESKECQGEAKSQTPGGAENIYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQH1</accession>
    <name>A0AAD2FQH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase NYN" evidence="2">
        <location>
            <begin position="271"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="481" mass="52784" checksum="6C98857EB7819F0E" modified="2024-05-29" version="1">MESRPNPPPASAPSRLVGPHKMSSLQRAAGASASHRNAKYRSSALSKKKKTSYTIGGSSTLEAKTTTSSSYSNDPPLKSQDGMESRTQQQHSHNYTVGNPQHEQDAPSHNGAYQKTVENDHMMEDDPMSPYNQNNNNHGYNHGNSSHQYHRQPIPHASLGPLSPTPEPPTSFIIGGSSPIPPSHQYQQQPIPHPSQPISAPPTYYGDSSPLPPLHHYQQQPIPYSSPGPIPPAPATQTSYAIGGSSPASQSRPQSVEKMEGVQDHGSKTPLVVLDGANVAHYYADALAAMNTTFSDKSRRRGKPEPDTRGIQVATDYFLSVGVRVLVVLPQYWMRKKPRPGDTSSQNAMMDTNQMDILKDLNDKGLIVASPPADDDDAYALTIAKREEMRAVRQRNGEGPGFVLSNDMFRDAQARDPTGVMKEWLKEGRNETIGPGRISYAFCDMGTMDDHGDRILDFVPNPRHPLVIYVEGLHHQTILNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQP3</accession>
    <name>A0AAD2FQP3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS12293</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQP3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="9">
        <location>
            <begin position="51"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="10">
        <location>
            <begin position="430"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1949831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53656" checksum="D2D6F3ADB82BE6A3" modified="2024-05-29" version="1">MDHENDIPFMDDSEDDEPPMLVDLNPPPTPELDPPPDEASENELPVCFPCPVTILSGFLGSGKTTLIQYILKSPDHGKRIAVIENEYGEGLAVESMIARDGVGNNNLQDLIELPNGCICCTVKDSLVSTLESLLDKRQDLDYILIEASGMANPGPIASVFWLDEELESRLQLDGIVTLVDANKILEQLETTEEAAQQIAYADRLLINKVDLLQSKGGGLDKVLAALKQLHPTAPTQQTNYSKVPNLDWILNTNCFGGTDRLAELNTIWQDSIPQASTHHHDHHMVDGDHGNEESRENHSHAQNDSGHDQQSENHEHTHTHSHDHNSSDPCVVCEAVQHRHTAGVSTIALHQHGSVDLSRLNKWLAHVLWPNQDAEDTVLTAMLHSSSAPKPKQDNETVIFRCKGIVSVKGNLDGDEDDKVHYDTSTGLDKRRFIVQAVHDLWEVHPASAELKWGDQEERDCKLIVIGKNLNEPDLRRGFRSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQT6</accession>
    <name>A0AAD2FQT6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042075957" evidence="1">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="109" mass="11670" checksum="123C8EAD82528E6E" modified="2024-05-29" version="1">MFKFCSQLILGLSLLFALLAEPTNARLTAGHRHLKSCEESQGLYGRCCGFDLSACSCPIREYEGFGDFIVKYLWDSACSKLEGKIAECSLTVGNITAPVDSVVGTAGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQX4</accession>
    <name>A0AAD2FQX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS12345</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF375">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042152934" description="Peptidase A1 domain-containing protein" evidence="11">
        <location>
            <begin position="17"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1051"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="223"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1949947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1139" mass="129151" checksum="0592AFF1F65A4A7E" modified="2024-05-29" version="1">MLDIQYLLFIFLLVTAWEDAKVTTNAAAAAAVVSDGLKQDWTSFTFDLQPASARLHIPQVSKTNSHRRRHWQHFGLNDTIRRYLGRNQRRHHNKRERNDGVLLSTNDFNREDLPEEWFHPNSNAVYATFHGTDNDDHPARIDFDKFRHWSRYERLMRHQLQESLESSSAVGNNQTLLQPHWDGDYEKLKPLLLPLPHPEDRNRDLQQFERYQSAPLSQGFGTHYIHLWIGSPLPQRQSVIVDTGSRYTAFPCEGCKDCGQEHHTDPYFQPSVSESFQPLECPLECMGHATCSSEIDEDSDNNSNTNNNGHCYFSQAYTEGSSWMGYQAKDLVYCGGRDLLQAASQLDTNYSIPFMFGCLQEESGLFVTQLADGIMGLSAQEHTLPKQLYNLGKIEYNMFALCFRRELGSSKRGVTAGTMTLGGVSSTLDTSPMIYAKNTQTKGWYTVSVKRIYIAKNGGRQFLFDSRKAVSSAKEDIVPILIDEDVVNSGKGVIVDSGTTDTYLNANALPAFSKVWRSVTGMEYKHKPIALTDEQLQVLPTVLVQFQAASSSFENYLKPVLGQVGMLDPKNSMDVLLAIPATSYMEYMPTMKMYASRLYFTETSGGVLGANAMQGYNVLFDWQHHRIGFSQSSCAYDLIEKEEQEKFGEIRDANPSGVCRLGRPILTTPCMDSIDVSICQASDNPTNVKIMGTETWTRLVLDPGKETDSCPSVMEDWSLRQNIQMEPSEIRCDHDGHCQEIRPCQVPCMVALDLASATAGIQSTKKKAGKTNVEGTGNCASTTKVWSACDYKCEQTKVSAALDDQDVCVESSREIRSCHTGACCRFDACLVPYLVQTILVLEGIEIDDWDMHKVEDFKTQLASLASRKSGWTRRRRKFFGAGDINVLSIQPWNMLDEAKRRTVEEDELSKENDDSAGIQLIIQISVFNPKAKTKPQDKLHRSLLREVEAQWSNTSASSDHLASSNCKALEMYSLAKDAVYLSTEWLKQPKFEVALAKGLPKVSRARVISAWTINTQIYDDEINYFGPIGSRWGPYIFGFRLFFELIYKACFIWIVCTFLFYSLDRCCILFNLVPLRQRWRSFILRVCKWRVGNKRSKFEELTPDDFEEIVESFEFELTTADYSKERSTTPKRRNLSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQX5</accession>
    <name>A0AAD2FQX5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQX5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="247" mass="27267" checksum="4FF49F918F31704A" modified="2024-05-29" version="1">MSNPTTSSQEFTTVPIGNEDTVASANNNNNNGNNNDNDNNNNNNMSSKEKAPNRMMRTTKNAWRKAVGCCKKSTPRTKIRLREHEIAKRKNAFGMQYIDLVCTHATEEQLQQAVQACLQDIEGLMQEIIDLENKIEQVSEETKSKIKTQPTGSSSTNNNKALYANSGLYSGGDPSIEETEDEDDVNHHHHNNNNNNNKSPPPQGAFSITENDDDDNADLNKDSWLPPPPSSLPPAVPVEDKPSASAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRA4</accession>
    <name>A0AAD2FRA4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042024306" evidence="2">
        <location>
            <begin position="23"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="333" mass="37032" checksum="7B9ACC9352118AE3" modified="2024-05-29" version="1">MFPLRSIIMIFFLLAMQPMAKPSLMSANYTRPSIQVSSLAKENVISIVDFVGTTVEMESTIDIAFFSFMEIIQSINYESIKTFAEEFNKKYEAFTDSISDAMSPIFEVFSKKYEASIQSINYESIKALAEVLNEQFESCTREVPAVISARFDMISFEYQQVYEKLVPFATYVLAAAPAWPTGSFDPNFIVRDVFEGMESYTTKDSLVPAPIPPLISYKESQSIAIKFLEAISFGAIGIALLVIAVVILRVIRVINRELIVSMGVFLFSEQVLVIQAAFIALKLKEKKAASVKGSTRRPDMSNGAAIAELCDLCANTSPLKDTTTNDPSKNESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSH5</accession>
    <name>A0AAD2FSH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1952010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="474" mass="54608" checksum="C99B3D811F521D8F" modified="2024-05-29" version="1">MPIANDASRKVVFFAGPHKAAATSVEEWFYNYYTKEDSDHFALRHWKWPIVEGPKTDQLDEPWKVFQELVLAPDDLEMKEEIMVSIQETFDESHTGIILGTESFDQVGRYSKGDATKAMKDILQRLGVSDKEVTVVINYRSPRLDQWISVWKHSGVPSYRSFMCDSQDRHQLREERIEQLSTLMDPLYMAQTFVKEGWDVRLIDMEGVDRANKDIVNVIACDILGGKCLMKDSIVYGHRGDETHFNVEDKDFRELTAEQRHEADKLFRARDCAFEEYLSKHPKFEVGYQNNLWSDCDKQDLGREDVFVYLAGMPQAIYSGLVNQFNCSEEGLTIDELLDGEHLENLTPEDVFADSKASNFFTIIMLPILCILAIAYQVMKRSKDDIGDGIVMGNIRPNMSGAKEKMSDAGKKIKSKLKRKDMYRDEFRDRRGMTVNEMSEVFADEDWKMSVDDDNQFSLFSKKKGNPTSLDLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVB4</accession>
    <name>A0AAD2FVB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="317" mass="34551" checksum="41155D69AC6E33E2" modified="2024-05-29" version="1">MDPGMEPMQATSGDAFVATEDESPTMAFLRAKKTGGVMNSGSNHSVPLVDKPEVVIPSEEPLDLDPMMDFQVLANHQGEGFHDDAGSIDPLDAFDIQDLELSGDDANLVDMALRSPDHSHSTDFDNHSHSTGFHGSVASGLSLDHGHGAMYENDEELQRKTEQIRKETMESLNKSMSSLNDAFGRLTASMDRTNKTRELLKQFEDQQNPLEELRKDAALTGIAPTPSITGVAIGGSRRRRGLERRGSNSSLTSLGSRGSLGSRGRKSRDKTTRKAKRNVKSDARSRSNSRSSLGRLSRDNSNRSLGGMPDQIIVRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX99</accession>
    <name>A0AAD2FX99_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042276582" evidence="1">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="126" mass="14125" checksum="78784034F318E927" modified="2024-05-29" version="1">MIRILNFLLLSILVVSASAQSYDYQDGGGYDEQYSQDSLYHDYAMKQQEKDVGAAQGGWAKVAAGTAAGWLLGGKIHSSRKAKNLNSKHKEEQKALYTQYYNDVYTLQQQNQELAQALEQMGVRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXJ6</accession>
    <name>A0AAD2FXJ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001911">
        <property type="protein sequence ID" value="CAJ1956269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXJ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="275" mass="30394" checksum="7F65E975D0493F6A" modified="2024-05-29" version="1">MGSDDDQSDEMALNLTKAATDQGQGGLEEKTRSNSTTQLTVDLVKDDPSDDPMELFETVWHALIPPKSGHKQPPPSKIAEDGALKGQPLVASPKKLNPSNDPMEFVEIVWHALTTAFPPTIDHSLDRFSIGWSTKQGRTQNKIFNYLHTTTILFYDVCAAHQKWPTTMGSNEAKSQETALKSTRTAPEHAQEGLEATTRSNSTTLLTVDLVKDNPNACISSMLYSLFVLFLSLEKIQQTDFLGLPFQIPTNRVGAPICPWERKAVVAESRRSGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYB7</accession>
    <name>A0AAD2FYB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS15645</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="73"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="274"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1955223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="423" mass="47791" checksum="BB374663EE0BB96E" modified="2024-05-29" version="1">MADNEDELVDYDEEEEAANVSADKSGEAKDTKKGHYVGIHASGFKDFLLKPELLRAIVDAGFEHPSEVQHETIPQAVLGGDIVCQAKSGMGKTAVFTLATLHQLSVEDDKVACLVLCHTRELAFQIAHEYERFSKYLPQVKTAVFYGGVNIKTNREILKNDCPHVVVGTPGRILGLARDKDLKLDSIKHFVLDECDRVLESLEMRRDIQEIFKLTPHEKQVMLFSATLSKEIRPVCKKFCQDPMEIFVDDETKLTLHGLQLYYAKLSEAEKNRKLNDLLDALEFNQVVIFVSKVARAKELNRLLTDCNFPSICIHGGMKQDERIKQYKSFKDFNARILVATDLFGRGIDIERVNVVINYDFPDESDQFLHRVGRAGRFGTKGIAVSFVSSDQDKEILSQIQSRFEVNIPELPDEIDMSTYAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYF1</accession>
    <name>A0AAD2FYF1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="825"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="102224" checksum="A4A511B2C349CD7E" modified="2024-05-29" version="1">MSAAKVSSSVCTGGRTRDEIVPRTRKLATTNDEKEQFMLILPELAEKVRRERHHESNHGWQYSSRRRSRRDRLRSRSSCSSNKAKSSGSSSTESTSRSITSSEQSSSDPVMDELQEKMARMQSPTKSSSSRRHSSSSRRRSTTSHRRTSNSRVGNSLSPRRRGSSSASSTRSFSNHQSEAIEMSSPRPRHSGERSRRSRSSTSHSPDNNNSSRRRRHHGGQRSSTRRSSSQNSSSESVGSLDLEDLVVPVGALRVDSIGQISVLSTSFHGSGSIPSEVSMGSDDHIDDGNNDSTTVVLENEDDGSQSSGTTRSMSRSNSCSLRSNLRSICEDQEEPMVEAVFAQNYEDELEQAREQGRREALRRAGGTNEIAVAVAANDRPSLSSRVDGDDEEEDDQTVDGKRKRTLLCYLALLCCIIIAIGSIGTLLFLNGSDTSDVSFVSDLEDEDDQSNLKAVIIYDPPTVEECQAIANGTMLDGQLSSLIQRTFDVQIELTLASQADFSALLNDLIGHIQQKLIPIMAGCQGINLFDATMAISDKLGNSTTTTPGNAITNGKVQEGSQQTCEGTDSIENCRVYVLVLDLYLEEEESNAILLEIIGENFVGEELTRTLSALHPTVQTASVPLIAPSSDIIHGGGDDVTSVPSDVPLLPEIPSPTQSPVQDDSTPTPTAPMGAAATGVPLTPPTHVPSMVIVVPTDEDSIALGPTRAPTSETITSSPSNATPVTVPTATPTRIPTAAPSSTPTTVSPTTSPVPPISKATSSPVSNPTTRPVPAATPPPTDEPSLGPSIMVTTSMPSKSPTLSPVVGPTEDPSGSPTKAPSRYPSARPSKSPTTAPSKSPTASPSKSPTTAPSKSPTTSPSKSPTKSPSESPTDAPSQSPTKQASPGLTPAVGTFCCSKNFITCGGVNPSCQASQSACSSCNNAAWIEEGTCTTGLGWNDECTNNPSGCCGGSCVTVGNKKRCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0W7</accession>
    <name>A0AAD2G0W7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartyl/asparaginy/proline hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0W7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051821">
        <property type="entry name" value="Asp/Asn_beta-hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332:SF5">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="4">
        <location>
            <begin position="82"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1959408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="288" mass="32085" checksum="5ED7424947EA69EA" modified="2024-05-29" version="1">MQFWEDVDEGLDGIESFYAKQGQDIDRIRTFSKRARGDLPKPEGCGPGHKPSEEHIDGLTAKPFWDLSENPELFPWAAELEAKSDIIQGELEDYLLNPAQLFKADSAVSATMGDGWSAVRLQRLGKYTENVKIFPGTYQIIKKLGIPLAVRGLCFARQAGGSGVAEHSDGRNFILTAHLGLKVPEGCWIKVGEEKRSWELGKLTTLDTSFVHSTGNSSNEDRHVLIIDFWHPEITPAERAALEFVYDLRNKYESGVIPLRKPKALQRQEQEGGLASIFNVFTNGNGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3B3</accession>
    <name>A0AAD2G3B3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YbhB/YbcL family Raf kinase inhibitor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3B3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL/LppC-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00481">
        <property type="entry name" value="YbhB/YbcL family Raf kinase inhibitor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289:SF1">
        <property type="entry name" value="PEBP (PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23720" checksum="DDE2C984603352C3" modified="2024-05-29" version="1">MKGTSHLDYAGIKKDHKLKSSSTVSKPMILISTAFVIILWLSSASSSKSEDPTVGKEKANKAKAAFELTCSGFANETIIPMKYARDGDNLSPPLSWSGIPDGTQSFAMIMDDPDAPTPKPWVHWIIYNIPSTQTSLTEGLKADGTMKEGQNSWSLSKYDGPQPPKGQIHLYIFKLYALDTLLFSGDTSSAGKTKEQLEQAFSGHVLAEARWTGKFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3Y9</accession>
    <name>A0AAD2G3Y9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3Y9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="249" mass="27464" checksum="A6017FE857E25904" modified="2024-05-29" version="1">MSEANKKTTAKGLTLNLIAAHVVGLVTLALIIKEAAAFSNATEALAFYGVYHREPGNQLIHFFGVPGILWSGLIFLVHLDVPFLSNNKTIQYLLPGSQQLTYGLILALVYLVFYLNIDPIGGSLYAPIIYAMYSSACYLHDQDQEKSGSKSWAGTGKLLRYALFIHVFSWYTQIHWGHKLIEGAQPAVLESIGGALTVAPLFAYYEFLWLIGLNQDLQMQTLQAVQEKTIEICAAGNTAMRVCETLKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4M4</accession>
    <name>A0AAD2G4M4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002100">
        <property type="protein sequence ID" value="CAJ1962210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4M4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="124" mass="14661" checksum="72BE6165C0BC883C" modified="2024-05-29" version="1">MAQNKILFSAKLDKNMRRSAYFETNKRTVKSNVMLKFVTKAMDIKLQGEANFTTTLEDPIKLLKRIEQFMKKSADAEYDFLDFWEANQKCFAMKQGTNKNLMHFKEQFLRHAEVLQDLHGVAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6L5</accession>
    <name>A0AAD2G6L5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002173">
        <property type="protein sequence ID" value="CAJ1964150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6L5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="239"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="516" mass="59244" checksum="6EC627F03D40B9CC" modified="2024-05-29" version="1">MFVYFPGKDNAIADCFSWLLQMEKPSEGKSPNKGKLIAFDKLQVSVDPEDEIYKFEDNVLVKENDLIMPPTEAEFNSTFRCQFSCCRDGDIHEHLTIDDIEMEESFLNPPPLQTMPNPITMPNIQQHQTQDQLLMQQAQRDAQHYQITTIDERLIITYQIDPARQDDWRIYLPLSLVDDVITWYHLVLGHRGKTSMYATIAKRFYSPGLKQQIERFNCEICQLNKAANVQYGQLPERHTDLVPWFSVAVDLIGPWKIDVNGRELEFNALTCIDPVTNLTELAFIENKTATHVASVFEMLWLSRYPRPYKCIHDQGGEFIGEAFQAKLATWGIHDGGTTSKNATANAICERMHLTVANILRTRYNNAAPNFQVAVEEVKRALAACNHAMRCAVSTALMNNTPGETVFHRDMLLNIPVIVDLLSMQQKRQYKINENLRRQNAKRKEFDYRIGGEVLIKNTDGRKLEVRILLQMFTLMVQWKFSAQMRSVRGSTSDGLCRSVESNGRYTCIAHCVKNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7Q3</accession>
    <name>A0AAD2G7Q3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002117">
        <property type="protein sequence ID" value="CAJ1962766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7Q3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="148" mass="16284" checksum="890F5F0FAB65AE4A" modified="2024-05-29" version="1">MPPISATAVSSLEEGAGMNISANSSIGSPSQIFGTTSYGSHSFSSPCGFGSPPTRTRPCYPLPDYHQDGSKKWPNVIYNFPEHGHRHGNAFICQGLIEQDHIEYQTITVNCSCPPDDYKFYELKIANSFEVPACFKSISVVFFCFESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8S9</accession>
    <name>A0AAD2G8S9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8S9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="555" mass="58601" checksum="29053D7864C5FF9F" modified="2024-05-29" version="1">MTDVVEIIEGEVAQKELQSAASRVRPRPPAHSRIPARNNSHQSKLKPVTERDESDDIEDLSASVRSFDGIDTDALKRLSAMSIMSTIDDSDRSIFSASSSSSSGKRSGSLNAKHVPEQFQSMDSLGGSNERYSLSSNDISYNSQFDSFSCSISSHAFSKSSQSTLGISGDIIESMGDLGQLLEPPTNIYQAQGTNRGPRVSGGSGNGSTATLPSLSEFSAMGSTSSMPSLADYSMDRSGHSSIMPGLGGIVEEDVSAGSFSSFNTGASFSTAATEEVGVIIGGRSVAEILKEQEHIAGRNLDVLEPTIRPKKPQMQQRWSSDERESSTGNAEIIDDAPPAVASRQESDTSSVYENSDHVQDLPPRMAQRRTSNSLSSRGLSQTPPSSLSSEGLSQTPALSPVGPPRKSVSGRTKRTMLPGIGGDTRVSDTSFRLSSIPLPTGFGELSEHSPVPNVAAPRMVLRQDTASSSVSTIGGLSQIPTLSPHNHSEGRKIVVPAQAESIETVQEVVPTNGRRAGKFAGGSEMDSPPAVAMRRISDELDGPLVDAPAGMVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G984</accession>
    <name>A0AAD2G984_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002298">
        <property type="protein sequence ID" value="CAJ1966540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G984"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="153" mass="17407" checksum="E0BD72FCCE523586" modified="2024-05-29" version="1">MEGDSFPLPPHPPKFNNRDGQIMMENIESCARTAYGYHGIRLDYIFRENSELVGDPGFLKANDSSCSIEEELVRRAAHTGAVFRRNNQKFWVMLHAVTHETDASNHVRQFAPTLNGRAAYFALFAQYRGRGHFTNERQAAVRVLATLHWNGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA37</accession>
    <name>A0AAD2GA37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="208" mass="23320" checksum="BABCD52031A3425A" modified="2024-05-29" version="1">MTSCPLVRNQFIRLEAALSMHTIPIFSSAALPQPWDEKSEATTPNKRYNHRATPNQHTTTSMTATVSALNANQTAIPTSPMHQSLPVKRHCSESVWNTRQAQDHQQLMMAFQRNQKEHDGAHSFQSAARKRAYQGDLQQTSFQQMEYTSSSVERIVKKSRLEASSSSLDTMRCDDDEAVSETMLTQGESPSSPSMQDAEEVWNFIGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA82</accession>
    <name>A0AAD2GA82_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002321">
        <property type="protein sequence ID" value="CAJ1967280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="119" mass="13712" checksum="466E34389EF6A130" modified="2024-05-29" version="1">MHTNVGSRVLDKEGFLGRFPPPVYHDEDGIANVLAMREMIAAGYRITMDTDADNAFIVHCDGNQKMQFVNRKGVYVLEQLGIKKMLIEEPMVLGALLLIWRIYKNRQKKRLYLSLKCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBN9</accession>
    <name>A0AAD2GBN9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002350">
        <property type="protein sequence ID" value="CAJ1967889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBN9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="89" mass="9561" checksum="885D4643EC321185" modified="2024-05-29" version="1">MGKSTSLKVVSTTANKAGGFTPKSVSVAKKSGKKRLENASAVDLRQPKERDPSVNNDSEIQELIASLPPLIEFGLSAHKLIAIGYNYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBP4</accession>
    <name>A0AAD2GBP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS23555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBP4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907:SF1">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="8"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1969138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="448" mass="50435" checksum="DCD194C81B850276" modified="2024-05-29" version="1">MDATKLSLAPMMEYTDRHFRHLVRLVSKKTLLYTEMVAANALCHERRNQVEEYRTNNALATEEEVQENYSDQYLQRYLKQGKVDPLEGASVLQLGGSDPKQMYEAAEVVMDMEKRGWCDYTAINLNCGCPSPKVAGKGCFGAALMDEPKLVEELTRALHDGTSGTMPITVKCRIGTDSQEAFTKAGYAQADEEVEYRRLCEFIETIAGGGIVTDFQVHARIAVLQKSFSPADNRKVPPLKYNLVRRLVHDYPELSFSINGGVESVVQAQQEFEACPDLAGVMIGRAWAADPWSFAMTDRVLYNDSHAPKNRLEVLQAYGKHADAEEMNGDPTKIRRFIIKAITHLFTGESNSKRYRIALDQIAGIPKKMKAEGKTIEGQPPVSELILNAAYEHLSEETLLRSPEESYERKLHEEMNRLGSIDGMNTRSNAVAQWQTQRKEEEEELETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBP8</accession>
    <name>A0AAD2GBP8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002299">
        <property type="protein sequence ID" value="CAJ1966543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBP8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="284" mass="32879" checksum="5C804E8C41D36CFD" modified="2024-05-29" version="1">MGPTLNFASLCHVLETEAGSNGDPHFKTWHNEHFASHDTGVTSRVPSFIRIGNAILEIEGSALEFDSVTHYWINYEYQGELTEFAGFPVKMFSQQGTAITKNRIEIDFEFYLSRTDKRLFFLPIRSLSRFLSRMQMKNRLETSVVMLGDFNTGQTLARDGVTVLDDFTELGHEWQVLRIPSGKHLFRVKRLHLKFPETCIDPEYPRGDRRRCRCRRRRRLDCPFVSEEEAEAACYGLKDELDRKDCAVYDILATPTKNGHGLSLPTDWLGSRRDICRFPLSRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBR8</accession>
    <name>A0AAD2GBR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1967986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="179" mass="20296" checksum="C864B145C42AC39B" modified="2024-05-29" version="1">MKEAVVIHCDRNVHPYDEDTMTNSSVFKNKKQHEPPAKYRSFNDEFMDSIDDIATRGIVPLDPLADDGSVELPDEDRYMAAGPIDPIPVQRREKKEILPKSKASSKEPTTRKKKEPEAFDRVKSFQTMDMTASVAMTEAGGCVNFFDAFFICVEEEEELRKTQSEGSEYSESTTSHQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC01</accession>
    <name>A0AAD2GC01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SLC26A/SulP transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS23692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC01"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF2">
        <property type="entry name" value="SLC26A_SULP TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="7">
        <location>
            <begin position="149"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1969406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="577" mass="63677" checksum="8F7B4BD6980B1BE4" modified="2024-05-29" version="1">MEESEQTTDSSYSFLSKSFESGGNFLRNYEQHDTKWDLVSPMTQRVILNRSTAPTQLKRRRSQSFNDFIDIVATETSSLLPPTKSVQLPHHHISEPLIGHADTQNGKHQPQQHEQNNDPEQQKELTGPQEAKLIDEPPRNPAWICVLFGVINASIVIPVVMSFGNIIYQNAAFAPYMPVLIKLTMVSGVVHQLCFSTFSSLPFAVGSVQDAGLIFLSSMASDMVVYCRQQGYNDEVMLATVTVGLGLAAALLGLGLVVVGKLRLAGYVQMLPICVVAGYLAYIGLFCGKAGIILMAGGRNGLSFPKLVVDNYLFIAPGIAGGLFIYYSVRKLKHVAVLPTTILLLFLIFYASLSMSGCTLKEATEDGWIRKAEPSPVWYRTWDYIQPSLVAWSALPRLLLTELSMIFVVALSSSLDVAAIELEVKRPLNYNKELIVVGISNMVSGLTGGYTGSYIFSQSIFTLRAGIRERLPGFVLAFCQLAVIVIPFPILAYVPNFFYGSLLFMICLDLMYDWLWDIRTKVTKAEYLIGLATFVLIQLLEVEYGIIAGVILYVVCRKAGVDVGELKIATTEDGIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDX0</accession>
    <name>A0AAD2GDX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002447">
        <property type="protein sequence ID" value="CAJ1970010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="43247" checksum="D4AB7624CD697073" modified="2024-05-29" version="1">MRIRRPPSSHEISNSNVNDNHNEEMESRGGLIFFLHVPKTGGTSIRRNFENLEHVEYIFGRNYSVYWNEAPKVEDLIQGKSLLQRNQNRKHKNRLRAISDEGNEQGKVLFFEVHASTAPSFYNLRQRLARWRQVAKRNQVPVFFFTVVRDPIAFAISHFNYFHVDVRNPSFEHVNATQENFLRFSLHNPQCQFLFKGEASMRKQLNKRKTKETSAKLDDSADSESSNPFNASAIISSDECSKVQDQMLELFDWIGTTETLSNETLPLLADILGRDGKFATYRVSDKVKKVPVDLWGKEHMTDFGRQVIQERSQLDLELYHRIQEEYPYCMWKTKDPQRQQYQQSPQGNENYEPQGNENYEDYEDYEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGX5</accession>
    <name>A0AAD2JGX5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGX5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF154">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042144792" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60206" checksum="EBF771552D1B6BBF" modified="2024-05-29" version="1">MTAQSFKYLFCSICLFSLQVNAFITTWNPAGNQHTIQTSTTTRNNQFPDVTPTLINQPIRSTATRLFESASLMDLLDTLEDKRDIPSLQDWAVEQGVHFAEGVLLVDNGLGDWGVGLSANHSHVANTPIMTIPPHLILSSQDARIAPATQSFIENKMATISPGMDYYHKECLLMMVVLLETFNAASSNWSPWLETLPRSFSIGLFLDPLERSHVGRMAPAFLEQQDKQWNACWNAIQQVVDDELVELPIGFRDYLRNYMMNEKSSSSSSSEEETADDERTLKELVQWAFGVVFTRSWRSPDGKAATLVPLGDMFNHDSSMANVFPSLLQQNDDDDESLAAKMPEGSIQMKLKQNVEVGSPLFISYGMGDQPARFLVNFGFWDRSASLMDANLTVPNTEDWIVDPSELVVSTRSGGVSEEVWNLAAYKFLLLNEQNAMTATKLAQARKDNDQASFQAILDDYDIPAIMYLRKHALQIISETYPDMDLCPEGNPIESPRRFGMIARYNNGMRESWMRVAESLEFELEDALAKRQEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHK7</accession>
    <name>A0AAD2JHK7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001767">
        <property type="protein sequence ID" value="CAJ1950438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="237" mass="26605" checksum="1E2421E59422DC0C" modified="2024-05-29" version="1">MSYTPRSADVYAYDPALPPTNAPIVSGATALYYGNRLDHSLINPNQVRKFRIPLWDNPFDEMRNIGIETKPIFVALKAKGTKLLFDSRAPTDQELANCPHIDMTSKVPWNPDTVQLGKISIVHEDPIDDPRSNEAELRQLDPIMQGMNEWRTVQQTIVNGERFFQQVGQMDDDAQFADVPVRPSFVSTERHTKATAENLSERLGIGFNRARATYAGRKSVGQSVSTQTGKDPVQVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIE8</accession>
    <name>A0AAD2JIE8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="341" mass="39049" checksum="46143C84A4BE64FB" modified="2024-05-29" version="1">MPQYSLLGLTPSGAGNKNSSKAKRPRPISKRAFLFGLGTSLYAIAGLMDLVSYWSNVNDEEDDELNDSLTENATPIAALAAFLYILMSILTLSVTPSALTTSRQHHHHHNKRKHPWWQKLLEDHLEVRAEYTLQVLFLIGSILLFGAEELKTHKLMRSLRKQQRASQYCFVGSLHLFWLSTYGLYKIIPNSDSESHDKKKTAEDEPELEQQQQQQQQQEEESTTTTPANTEGSLEKCGRLLLIMGTTIELSLIYVEYFSQAKISTSTILMGTFCSALFWWTNALLVCMKERYYYPDHLLIGLDKNDGNIVDFSFEDAMNLPDRLRQRLQAHRRHVTHIRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK91</accession>
    <name>A0AAD2JK91_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS17434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042030218" description="Peptidase S1 domain-containing protein" evidence="5">
        <location>
            <begin position="33"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="37"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1958952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="539" mass="59215" checksum="0DF9CA464835696A" modified="2024-05-29" version="1">MIPFAISNHRFLTMQSIYLGLLIASSSIGVNGQQPRIVGGTEASEGDFPFFVHNGHCGGSLIHGDIVLTAAHCHHKSTRRTVQVGALQRESLDDGSKYATVESEMLHPDFAKGNNEFDFMLLKLGGWVDPQHVVPLNNQFRIPPMNDPDVVFDIMGFGQISEGGPQSEILLHTTVKPVAAEQCQEVYEMYAFDEATMICALDNGKDSCTGDSGGPLMYNGVLVGITSWGLGCARYPGVYARVSAAYGWIIQNVCRLSDQPPAYCDDDWVDTPITQPTDGVHWVRVDLQYESDAIELDWSLVNTDTNEIVAQSSNEKERFDHTVVSTYAFVETGNYDFNFNGQGSYKVSVIRNRATISGDGEETILAQGTASRPLRIADPTTAVPTRAPTPPPTVGEQQVETQIPTFGMTESFAPTPVVSASPTAYTGPTVDIEIWISIAQHPEEVVWRLLDFSGRSVIERMSPGFYTEEGGWISTITLRAKGIYTFVVTEAKGRSNVRYSILAVDDKAEVTDYLVDDQTDRSLDPPTERNFHRTSTFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKU0</accession>
    <name>A0AAD2JKU0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002024">
        <property type="protein sequence ID" value="CAJ1959797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKU0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="259" mass="29554" checksum="EF031ADB5A7D5F5F" modified="2024-05-29" version="1">MSQDNKVLYQDCQPTDSLSFHLFAEGMVARMGDYSRPSVALLDRHIQALGRFLDRQFHEATSNIQRQDIALAGLANLVLWLGWLCSAECFGLNWEDCSILEPEDYGQADLPRNCGMVTFRLNPVTKSERTRTANVIIAYTAWSGLCTGKWFRRALSYRVRCTGPVFCHANGIAWTSFSFRSTYLYPSLYKQRLEGDPLLLPFDGTPSNTIESRFWSLHCYRRGGRSHVSPGEICGGRRLTIASETQVYEHSRWRLMETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLZ1</accession>
    <name>A0AAD2JLZ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002127">
        <property type="protein sequence ID" value="CAJ1963059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLZ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="100" mass="10225" checksum="4489F3848EA51709" modified="2024-05-29" version="1">MNLERKAAKQGPDGGGQVKLRARRGQMCFTEGGAGSWEGLGGAGSDKWESISTIAKGSLTCWAGAGEFPTTTSVGGRSELDGAKKSGDDSTDSEPSLSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM78</accession>
    <name>A0AAD2JM78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29914" checksum="EC02ED1135C87E7C" modified="2024-05-29" version="1">MPTSYFDVDAILAEEELIPCTTLFEFSHLKHLDPDASIGGGRSSSSKKSRAKNYLEENSRIKLPLWALEKWANLGFVRLQLPRHYGRKARERLEADPGDADLRKKNERFFLAGKVLVDLILTSSEKVATAIASSPRWRQNARRTAHTRALEQVSEDATLLKRTLLKTFAGERLRQMFNWALSTGGDDDVSHFLAKLTEMEKRLFHTGATAVANKEHWSVFGSRRLVSANASVNKRRSLTANAQEEASRVASPDANENGPKRQRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN19</accession>
    <name>A0AAD2JN19_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="887"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="810"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="892"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1127" mass="125924" checksum="994C10FDC1241A65" modified="2024-05-29" version="1">MSSRPRRKHKLRHPTGATPPHSPFAQSSSSSTPFSSPLRFTPKKSLLRISSPKATKSPRLSSSKLARMMLPGSLPLDGDTTNDTTNNSKENVVTLPFDDSLRHYHHQDESYPEVPKTPVPEHKKLLNGDGDGDGDLPDDISSVSSGSKNGKILVTSPDEKNDDKSRSVNGSSNGGGEEWEYKQFTGTATTPKRSKMGKLLGKHKRRFMFRKKKKNATNPSSSGASAGGHQEQQQQPSETSFEMQQSQSRSLPSLERQQLSLQDLDQLPQEQPRAPPPAPQRQQQQPRPPRQPMLSPIRIKRQRKVQPQSNADAAVNGDDGEEQDNDDDQEDGEEEEEESPRKTPRRILIKGRHRAAAAKKAVRSDALWTQTILIDSSSSSADEEAKEQVNDKHDDDDNNKEEEEEDIPMKDEAEKEEESEGSPLPITTPQKGEEKEQENVKATLATNDSGNAPINANTTVDTPDTVRSDSLWAQNMMLGGDDQNDDADSYDNILTPEAIMSPKTMTTASPATIITSTALAASKIPNLEEHDEQDENNENGEKNDNDKMDTRDTISMGRRVDSDRDDTTRSSRTMTSAPGEDGNIVDEDDLLDLVPSDEQEDHDDNDDDDDQYGEEKIVEEKDNNSTDGNYYLQQILSDDEDDEGGVVSEHDEELILEEQNNSRRGPRSGSFDDGDLILSDILSRDGSASFGIGPTDEESNGDNNGSVAGQDNGGIVSAPQSPVLSEIEMDKDDQHHLPVHQHPEICEEPLKAAIPENETVAENVNTSFDSNFTLNDSDLADMEKEKPLSISDRSSMTNMQHRLLSMRTIKDTYKKKLLLQEQETEQLQLQLLASQYEAREAKMSIQASEMALANERSKLRASENDREQQKALLLNLREQLSIVQSHLNKSQLKREDGPARSGDHSEPPQTTSALSSSSSYDMKLASMEEQLLVQDEEMDQLAMQIQDLKGKTAELEVSKREAEQKWKEALAREKILKEQLVSLQMGQQISNEKQGENGSDQQHHEIQRLEELIRANEERYQSESVALRQQLENVQKDHESELSKLREAVELNQKLVDSSQKEAQVAQTKLLQELAEAKLEHARTIEELKESLSSTHEQEKRKLHTQYSNELERLEDEIAGSRSELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN82</accession>
    <name>A0AAD2JN82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="47358" checksum="C5ECC45D2AD723C2" modified="2024-05-29" version="1">MFTETFLQAKNQDCLEQVLSFLACKELANVGRTSKSLHHSIFEANETEGNVSMIWQGAEQALTNPGRDKREFFSAKTQRIGSNAREHCRLFATASKAAKVFEMIDEMVEEEDRVMVDGVLANLMNVRDHDAKNVAEKKAIGAKDEQKTLEEGASEQEWTRVEMDEDFAKSRKEKELRREERINELRQLSPPDAPDNHEVFVRITRASSGEVISQGFCGTGQKFPWWFGLDIGKEAVAFGPPQGFQIFLDFESLKQSEEMQSFQEYYSEPEGQHGDNSTTGFMTLGFNMTALIIDKRNYKVHCLFQHDQTEDITCRRSMNQSFGFTRDLDVYEYRLNPKWGHAVVQLGPSMCDDRYYLSYSLSLYVAHLKNGGCLFLPSLDVDISPDSSVWNLSMQRLMESDSSMIPSASPQTTNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNJ7</accession>
    <name>A0AAD2JNJ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37524">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37524:SF2">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE FTSJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="481" mass="54979" checksum="8F13E47B3E7D19EE" modified="2024-05-29" version="1">MSTQGEENPKYVKGTRIFLSEVDQTLGEGKLRIELAKVFEVFGELREVFVPTRSTKAYAFIRFNLPEEAQKALGIVTPHPLFKRLKPAKDIAPRNKKHDKQKQKAVSEFEFYFSAISRSNIVCQVHTSHYERLFGFLEKHAEKVGFSVVGGMAKTKSRTISLVFVQAKKRKSFYGWLNSFWFLQNSVHRIFLVDATITPKTPEESIESSIMDTLSTLDQGSVRLQIFPPRLCSSLLKSIDARWDSFEKRNSVKLLPTNTTNTMGVVQLLTPVPFVHNGLYCSGIWESNLTESKSSSRSRIDTVDNDISRAYWKLEEAFDRYDGSLPTTSKVALDCGAAPGGWTQFLERRLECQTIYSIDPGDLHETVLGLKGVKHWRKTIQNSLPELQKQKSRIDIWVSDMCVKDMEQQVDWLLKALEMDVVGSGTFIVLTLKCIHGHSSSTFDFLVEQQLKRLKPLARDLQVIHLFYNRFSERTIMGYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPJ0</accession>
    <name>A0AAD2JPJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002453">
        <property type="protein sequence ID" value="CAJ1970045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="89" mass="10535" checksum="2CAAD078F9622356" modified="2024-05-29" version="1" fragment="single">YHWKNGEIILDGDLLAGVDPDELWDDTYIPRENEYKQSDENLCNEKIDQDEIDALLEEAEEFIENYDDEHTKNVENRQKTGVLQVFMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPQ4</accession>
    <name>A0AAD2JPQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002480">
        <property type="protein sequence ID" value="CAJ1970224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050744">
        <property type="entry name" value="AI-2_Isomerase_LsrG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33336:SF1">
        <property type="entry name" value="(4S)-4-HYDROXY-5-PHOSPHONOOXYPENTANE-2,3-DIONE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33336">
        <property type="entry name" value="QUINOL MONOOXYGENASE YGIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="46"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="289" mass="32721" checksum="8C6AA3A2BAFE2505" modified="2024-05-29" version="1">MLKSRLSIFTTRSRRLVFPTTQSLTISSSSSSTSTTKRTINSDSLFALNLQCKVRPEIRNEWLKQIQEDQLCSRRDEPDCLQFVLGQGVDDENAFYLFELYRNKEAFQHHGQTPHFQIYNNFIESSQPYIGEPEVCFYHPLEETDSTTKRSIQKNSFGLNVNLYPKASVRNDFLKAISDNKKGTDTTEPLALQYFYGEATNAPGQPELDGDTTTSTSTSTTSTSTSTTSTSTTSTKPFYLHEQYSGDNHGKEGFDAHASSPHFAAWEDFVATDPFEKAPEVFFFRILEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUJ9</accession>
    <name>A0AAD2PUJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS12331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1949919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="486" mass="53020" checksum="28574839B879EFD7" modified="2024-05-29" version="1">MSSNTPYYNAAEGPAILDQGNAEWKRGTKQGAKCQDLIWGILFYVQLGVIGILTAKYAPIMTVELAETYATSNYNQGRRLEEQNEQNNAFEVNVGQIWFLVGTSALISGLLSTFAMTLMSKCAQVLIKMALFFNIFVTAGVTIVALVAGGSSSVVLLCGVSFVFALYYAYVVWNRVAFAASNLVTATTAVQANLGLTFLAYSSLILSMLWSVWWAVAFVSTNYVLGNCNPDGTCEEELNGFIVFLLLVSYFWTAQVIKNVVHVTVAGTVGTWWFAPYEASGCCSQAVRDSYTRSMTTSFGSISLGSLLVSLVSATREMLYAMREQNNSLLLCLADCLLGCIESLLEYFNSWAFVYVGLYNYSFIEAGSNVMTLFKSRGWSAIVADILVDTVLLMVSLAVGILTGLSLALLASFANWSQEMRGVALIAGTVVGFIFCTTMFSLISSGVNAVIVCYAEAPAEFQENHPHLAQQMLGAWKQAYPNEFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVP6</accession>
    <name>A0AAD2PVP6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS16299</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001916">
        <property type="protein sequence ID" value="CAJ1956576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.530">
        <property type="entry name" value="DNA polymerase alpha-primase, subunit B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043034">
        <property type="entry name" value="DNA_pol_alpha_B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013627">
        <property type="entry name" value="Pol_alpha_B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08418">
        <property type="entry name" value="Pol_alpha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="10">
        <location>
            <begin position="195"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="338"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1956576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="643" mass="70333" checksum="79CD3DC70C34EDDB" modified="2024-05-29" version="1">MANSTEDRSKHEIREALKKVGLKKVDNKALIQCVALASTLNVQPEQMAECWEAFSLNKGVSELTDHTLQAYRLQLIKVSEASINPTIIPGAVQSRSTKRQASNMVTPPNTKRPNHRQTAASTNNPAAKSASTSNKLPKYESRTRVGEVVASFNLSHFDPIAPGNKHASCTITPSSDNILVPYRHMFTTLEDRASALEAKLNELGEQIIRQHGIGSGDNGIAPLVEINVPGHDKGCYIGRICNEAHQGKMNQTSVVIEGSSLSCGGARINVDLSTLKSEKIPYSLFSGQIVAIEGMNPTGRSVVAHRICEGAAHGCNKSTIKDLRHHHYEKQDGSAAKVVTACGPFSTSDNLDYQPFVDLIHVIMEQSPDVVILTGPFVDMRHEAIKAGNVQLEVDDNVHQVVPHEALFANKISGLIEEMYTTETEISTQFVLVPSLEDATARMVYPQVPIQDHSGRPEVLKLQGGNMVEVGTLGLERLNAGGLKRIHCFSNPCTFRINETVFGVSSTDTLFHISAEEVNSNLEPGSRLRRIAQHMLQQRSYYPLYPPPASVSMNLDVKKMDGFKMPCRPDVLIVPSRLSPFVTSVLETSVVLNPGHLTKGRSGGTYAIMDIHPIKREKLDGAGDDVQLLHNIPDRVNVAIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVV7</accession>
    <name>A0AAD2PVV7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001950">
        <property type="protein sequence ID" value="CAJ1957699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVV7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="420" mass="46789" checksum="313327EB144AADAD" modified="2024-05-29" version="1">MTIHRISKYGKFLILVQRTHTPALGTIPNLLFIGQFYDENPDLMEGDSYPLPPHPPKFNNRDGRIMMENIESWARTAYGYRGIQLDYIFRENSELPAAGDPGFLRADDGSRSIEEELVRRAAHTGAVFRRNNQKFWVMLHAVTHETDAYNHVRQFAPTLNGQAAYFALFAQYRGRGHFTNERQAAVRVLATLHWNGKARGFTWNTFISRLIGAFNDLELNVDPRSDANKVDVLLEKTVGDSSLSNGRSHITGDAVLRSNFQGAIDYLTTQVLAAGNDNTQRRNRQLAAFTRGGGGRGGDGRNGGCGRGNGATNRLQSNVPDRFSRNGILLNDGGYSNQIWREEFTQEERDICLAMRRNCRNGGGRGGRGREGRGGRGRGRGISAVHDGRADQEETKEDNNDGRGGGAGMSRCRRNNRDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW84</accession>
    <name>A0AAD2PW84_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35399:SF2">
        <property type="entry name" value="DUF839 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35399">
        <property type="entry name" value="SLR8030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="PhoX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1023" mass="111767" checksum="708BD33750B07313" modified="2024-05-29" version="1">MPEPALPSVTYADYKRAIRGSKRKNDTSQSSSASMKEEAVAYPVVKSSSSSQNSKKKGRTSIHSGVKASKDSSSLLQNDVATSSAQIEKDVSQQNTSETNTHNNNNTDQQDEGFEVLEQQHSGELETSSLTIQHTISGESESPLEQKQNNTNNNRNNSCDEGFEVHDSTLIISSQRQQGEPQHSTDNAKTEDPIQITESISFKSADDSIFSTEGQQQKESPPRKVVHTAALASDSRLRLFTTSAIDMTGCIRKSDSPESSSNGGGSDSTRSNNIRQLGFPHSPNKKSSSHSSSSSPEKEEVSSEPGKSLDQRWQDFGASLTLLGAPVLSWFSATTSDGVVANDDEQQVTTQPTTSHDDKDKRTRQDSNSSEYADMVLDTAPVVDDTCSSSSTVSKKKITTSSLSSTDQGSLSSHDGVVGETTPRAQIALPRQLSRLFSAKGGAGGGESDNDKQDGFSIADWSQKTWNKVVTSIPSKDENPKRWYQLLLGLYLISASIFITIMVLVMKSGGGTAAFMLSQNSSDIVRSSAPTVTASVVPSDSPSLVPSNIPTNSPTITGRPTSSRAPSTVPSEAPSHKPSIEPSGNPTMTAMPTSEPMTYVPGKLTVESNGLKLSEGLTSRIIARSGQKVLLDGRGFLPTNQEDDWNHTTSSSTTTNSSSIAPSSSPTAWSIESDEVFHFKPDGAAAYLWPENDDYNGKGWVYVSNSEVWDQGDGGVGAIYFDDQGRVVDYKMLINGTTANCSGGKTPWHTWVTCEEADDGRIYQVDPLGIRPPEEMTIGMGQGKWESFAYDIRDQTKPRYFATEDKDSGTLRRFTPDEPDWDDPWTMLQANGTVDFLIFEPFDLDGRTSGTFFWTTDLRAAKENARRFFRNSEGIDVRDNQLFVVSKVQKELFILDLDAMTYEVHSTVVGLFDGQPDQMKRLISDDGKAGTKHDKSLLYFCEEGGRNNGIHARDSSGWYFTVLESDTLDGETSGLAFSPDGKHMYFSYQHRGIIFDVWREDGRPFHGKTLSVKYHETGEATIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXY1</accession>
    <name>A0AAD2PXY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002413">
        <property type="protein sequence ID" value="CAJ1968896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="59547" checksum="7924318B4AA29022" modified="2024-05-29" version="1">MSFSSFSTHPEDEKTLAENAQSSPSIPPPSPPEPPSPNPPPPPPQLLNVPDLPSNQPDNDNAMDYPPGSPSGPLDGQSLILMGDDNTISSINTDYHTLQMRAQDIENHNDGYREPEHPTGSPQKSQQYQSRSPNPEMARLPQTVDMKTTSQNKEQPKQQRQQQDDEGSCLPQWLVDAPFWLKLVIVTSTALLLGAMVLIGVAASLEVQSRENEAQNNAAVSPPSLAPGNFFPTQPDLEPTNIPLTAEPTSSPLEDMPPWQPYNTSTSVQFFVAGGRFAGDELANLPAELSNLPNIDGNTVLFHLGDWNSPSLTRCEESAYSDIATLFANSSLPVYFVVGDNEFNDCPDPREAFEFWDQYLLDFETRHWPAPSVWNIARSEDYPENFGYLHRNVLVLGINLVGGVVHDNREWERRHAANLEWINTNYFENEARFDTMVVLAHADPEILANESFFLSFFRLVRDVYTEKQVVFIHRNLGSDAWGLETGYDGIPNLMVAVVEGTVWPPMLVTIDTTAGILEIDQRQWYQEYKTGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXY6</accession>
    <name>A0AAD2PXY6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002421">
        <property type="protein sequence ID" value="CAJ1969016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXY6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40841" checksum="AB9A5C65DA4497B8" modified="2024-05-29" version="1">MEQLLRIFAYLDQHPKMTLYFDWRIPNADFSGVKSSYKEFRTLYRDAEEQLPSNMPKPRGRRVGSLAYVDASHAANKKTRRSHTGYVIFLNRAPIIWHSRRQNTVEASTFGAEFIALKSCIEAITHLRYKLRMFGIPLDEEPTQVLVDNEAVVKNSSLVESTLNKKHNSIAYHYARWNVAARVIAVSWIDGAINIADAFTKRLTQMRRENLFGSWISFYERLSTFLYLYHPPSKSIATRRILHFPVPSNRKKNRAKVNKKWYYYHVKSKSWKLCDDQSKATNRPHALLSGAPTPAPAPAAPAPAPPAAAAPVAPAPPVNQVPSGDASALTAATSATNLPQIRQQVSTIATGMNQLIDQVNRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY99</accession>
    <name>A0AAD2PY99_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002478">
        <property type="protein sequence ID" value="CAJ1970195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="159" mass="17973" checksum="77BBBEFDD78FFFF5" modified="2024-05-29" version="1">MRRTRITDEESRTNESPRKSKNRRANNHPSDGAEFAREFGHKAVPGVAPAGEQEHDAASQMQTLYLRAREDAQARVHARIRRTTQPTAGGKYFHFFSKYIFLDFTPPNLPLTCHFGLGAFRGRYVFHLAVRSSTGTGLKVSLDDPLVDGTGLRNRNRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBQ2</accession>
    <name>A0AAD2CBQ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1894691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBQ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042261508" evidence="2">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1894691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="266" mass="27235" checksum="09748EBEB270F779" modified="2024-05-29" version="1">MMNQFTKALLLSAMVSMASAVDDDISHFESPLEEDVPIVSIPCFANADGFGGSITDTSFTVEYYYEMVYREGGDPVDDLVGSFERDSTNFLLQSDLFESPCNEVIARQAGAAHGITSNPPDVALDGIPCTTISGDDAVATECVVVNGAFEVFYIDDGSGSEALEAQFKAGIEEGINNGSVSISNPDIVEVAAVPDPESTPRGQDPAVTPEGIVANPDDDGNSTPVIIGAVVGGVLIVGAIALYKSRQAGAAASGAADAGASAGADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCJ1</accession>
    <name>A0AAD2CCJ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000077">
        <property type="protein sequence ID" value="CAJ1929309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCJ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1929309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="397" mass="45455" checksum="CC684EE8C6B4C22A" modified="2024-05-29" version="1">MNRLTGKKKQRLSATSIFIWIAVGCGIAMLVVSSTTSGAYLRNNMSRKLSEIYEEAISNNSTRTNGLGSMLSLGPEEDRLLISELTQSPTPGSLECPEGFIAIYDRIIPETNSTTVKRKIPKILHISYKSRCLPAEVFGAGVQRWMDELPDYSVYFHDDDAVDRLMEAEWPEFPQLHRIMRCLQYKGAMKVDLWRMLVIYRFGGLYTDIDNVPAEEFKGGEVIDPEDTFFSTSDSWNRPNQNVFAMEPFHPIAIFTIQTIMKNLYEMTSLRKPQVVFVTGPMVFRDGYISYLELSYPYKTHEQILEAGLKKGKLGKQIHKEGQWNWGNIIGSEGVEYDGKNMSKKERDHLLAGTYHWSKVVYWNRNGLDLSCREYLYQLEHPSPENGIAANWTVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDM3</accession>
    <name>A0AAD2CDM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS1124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1925111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1925111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="155" mass="16744" checksum="A21ADE91075B56E9" modified="2024-05-29" version="1">MSYKEGIILAITELKDRNGSSMIAIKKHLQGNLPKDKKWINGTFLKVLKTGVANGEFVQIKNSYKLSPEFKKKVTKKPAAVAKKTTTKKAPAKKAAPKKKATAKATTKKAKSAPKKKATATKKAPAKKAAPKKKTAAKKTATKKKSATKKSAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE95</accession>
    <name>A0AAD2CE95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Catalase-peroxidase</fullName>
            <ecNumber evidence="9">1.11.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS2116</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="9"/>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE95"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="183"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1930845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="787" mass="87095" checksum="BAD9F7CF0506B56E" modified="2024-05-29" version="1">MVSFHRRSNKMTASDFDRVRLEGVERTTFSRKLSETQSNIPHLDTFTKRQLKLDECTEATMSSPKCPFLHSGNGTNNKDWWPEQLNLKILSQNNEKTNPMQKRFDYSSGFLSLDLEAVKKDLRALMTDSQPWWPADYNHYGPFFIRMAWHSAGTYRIHDGRGGAGAGQMRFAPLNSWPDNGNLDKARRLLWPIKQKYGKKISWADLIILTGNVALESMGFETFGFAGGREDVWEPEDDVNWGQETTWLGDNNRYKDNRELDNPLGAVQMGLIYVNPEGPNSNPDPVASAKDIRETFGRMAMNDEETVALVAGGHTFGKCHGAGDASNVGPEPEGAPIEQQGFGWANKYKTGKGGHTITSGLEGAWTTNPTKWDNGYFDVLFGYEWKLTKSPAGAFQWTPIDKSASNKVPDAHNPQKRHPPMMLTSDLALIKDPIYRQISERFHKNPAQLKEAFAKAWYKLTHRDMGPYARCLGPEVPPPQKWQDPLPTLKFAPLTVADQAQLKESILKSGLSPSRLVATAWASASTFRQTDKRGGANGARIRLNPQKTWLVNEPDELAEALVVFEGIQSTFNATGKKVSMADLIVLGGCAGVEAAAKAAGHEVSVPFTPGRTDATQETTDTESFAVLEPLVDGFRNFVHPKLGKVEAEELLVDKAHLLSLTVPEMTVLVGGLRVLGIGASGSSAFTDRVGVLTNDFFVNLLDMRTKWSPAGENFFEGRDRSTGESTMTATGVDLMFGSHSVLRAVAEVHACKDSEEDFVHAFCLAFAKVMDLDRFDVLSTRVPSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEL4</accession>
    <name>A0AAD2CEL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS1567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000063">
        <property type="protein sequence ID" value="CAJ1928896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990385">
        <property type="term" value="C:meiotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051257">
        <property type="term" value="P:meiotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="9">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1928896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="631" mass="68876" checksum="FD26792759BD7809" modified="2024-05-29" version="1">MVRRVVAVKPIMDNVRQIQTSIRRVVEEPFHPKTNVEKALLGEIEVCRALIWQCVGGQEVNRQDSPPTCTNDKHSKGIPLPNSDRISNSSETKQQPNCVEIEFQVNAMKVAELRKELKRRDLETNGLKKQLQARLREAMATENTTQRAGSVPHHPDCTSSKQPIGAEKSEASVAQQGNIKGSKESCQLSDGNDNFTEMRKVSDQQKTGSLKSSVNSSQSSHEAKVSSDEVQGMVGSEGVEEEKWSTNSTSPKQTLEGEGASNIKQYWKKLSKPANASTVTSPIKVAMMTHSESKKKKSPIRMVVKTVQKVLPAANDDPVQDIVISDIVISASNSDLTDDDFDGPISEFSETSAPLVPVQISKAGSVRDLVSKIQKSTSSASNTTGGVEGSGSALSKNLQAKKEARLARMAEIRGKSKPVMTSKHVLAPKEYASTLSSLNAVSAPVGLKKNNLAAQMREKAATMRKENVLSGVNDVFTSTTESGKRDLQSSADSSDDQKNLVVSMSMQGFLKKQKVASPMSTYEISDREKSDSDTSDSEAGNEKQKKKIPVWAQKANLLLALEEQYNGCVGGLRVDPDEMFPEVQTCDLEAIFGGKKSRYTLRTSSGNWTRDKVTTAEKLVYKRTMGFTLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEM7</accession>
    <name>A0AAD2CEM7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase of the ABC class C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000069">
        <property type="protein sequence ID" value="CAJ1929059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEM7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046834">
        <property type="entry name" value="ABC_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149:SF1">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase of the ABC class C-terminal" evidence="2">
        <location>
            <begin position="164"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1929059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="666" mass="72412" checksum="16793C23F0B697F7" modified="2024-05-29" version="1">MWNITTLQDPLASYVKGGNDTTSSVVISASVAHVNIFKNDDASAFQEGGRPAKVALADFIARTLVKQRSQAMKEVENFVLTLEPLDRIFLKGKRRRQNLSAPYPPYVLERSDIWSSNDQVHLSLRLIVESQSKQLDEKSDFLQTAVSSILASLLPFNQVDWTQAAMNHISCVVLQDKIRQQLDSSNAVGFIANNSILPRKSGTSDAPMSSPPAVPFQAPPDSSMTQSLTIEMGSLAGYLPSNVVPSQGSSIALSGLVIPKGITLICGGGYHGKSTMLRTVALGIYNKIPGDGREYCIAVEDAVSVRAEDGRYVNNCNISAFISNLPTLPGATKTVDTTHFSSRDSSGSTSQAANVSEAIEMGCSAMLIDEDVSAANFMARDGRMRALVMDESITPLLYRVNGLYNAKGISSVVVVGGVGDWLDVPHNVILLDKYVASDATEKAASISYQFSYGHVQYGGKGVVHRLDWEYGGTPIPRRPTDEFANRFSSNIEISLLDGGHSIALHPHEDDDETMDGGHVVLEDDHDEGCIEASRMEQVMGRKHLYTCGLCALWIIKASQQQKTLGLPDLLNKLDETLDSSGLVKVVEDLSSSGLSPKTWHHLVEAVGFAQRPRKFEVGQALTRLHGIQFEELPVENELAAKLAAAKAEEERKRKALADLWAARRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGJ0</accession>
    <name>A0AAD2CGJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000334">
        <property type="protein sequence ID" value="CAJ1934096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="16031" checksum="F014D793D9C9D2E1" modified="2024-05-29" version="1">MPDANMSEPVPAAHVVTPQRNGGQNVAPTRVPFVNATAAAAAPAGAAPPLASVRTRHELIIKRGIYKGKRGYLDESRGHGGYSPTRKSVYITYIDEDGVEKIASHCVRSTSITLVNWSTPLNSTNPILQRHPELMREILSNGVLDPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKD9</accession>
    <name>A0AAD2CKD9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000451">
        <property type="protein sequence ID" value="CAJ1935340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKD9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="334" mass="37453" checksum="A53CD8CD39AE6F18" modified="2024-05-29" version="1">MMAHLKRKNIESQEGAVSLSGAFTKVTKKKVKKKKSPLSDNLENHFLKDLSPAQRKLAEATDRKLQNNIDRHKAGPLFLMILPGEMEGSYIFVCRKKYGQLARNVLKGIIPFLIHHLCELTDTQADRVLGKWIPKSEIQATRRQLSIGMDMANAKDIDDGQTVTGMLDEMHEREQQLEEAFVEIEACDNALAAKDQALAQQKAATAALQAQLEALQRQTAHHLAFDSQPPAQNNKVSPDRSEFTTPPKKRKSKDTSTVKRGASTGLRLVLSRPLSQLAPARLFTFSSRSSGLRKSLRFTWTQLRWIYITESLIGIYATSRVSNCRCNTAVEARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKU6</accession>
    <name>A0AAD2CKU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="2">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1906295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1906295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="783" mass="86856" checksum="4B6FBE1F44C3FF3E" modified="2024-05-29" version="1">MRTVSLTQLLSTCVDASHQGCKIIRAFQEKGYGEGKLKEEGDARSVLTQADLDAQAKIIGSLRGTWGSELNIIGEEDEGDAAPTFDGNLLNMNLLDETSLQDEELSLDEISLFVDPLDGTREFVEGRLENVASLIGIARHNKTLAGVVGLPFAQAPEADIVIHYGAAHQKGSAGTWPVLKEKDGSIDDNVVTVFTGDSKDEILQKATLHALNLAENTRHVIVGGTASKFQRLLSVPNSVAVLHFKSQLWDTCASESIINSKGGKVTDMFGSPLVHSPQRSFGNIFAVIASSGDKEASELHDKLCAQMRADTKAVHKIFGKWMGSTEPSTPQAVDVIRNLDGIPLSTKEIEDFVLEGRKGSLKGYSAPESGAWRGMMSNGGRLLLEWENNDDGELPSSVFYKRIVMADLEHSRNKLMNAPHKLIRDVKSYQVETSFLTSRACQEGLIKEAGLKINKVFGSDLRPVASTFGPKEQLQSKFSILLDDFNAEDGWEQRWLLDESAAKASIAEFAKMHAYFWDGSNFWKQQGGQLAEELEASVWENGGYMQPSLQGFEQYEIVAKGFEARLPTFEEELKQIPELKDADLVNIGKRLESLVARAGRESHPFKADKATSDEFKRYRTLIHGDPKQANIFFRKSSQGSYQVGLIDFQWTGFGLAATEVAHHFSASLLPSCLSYDGVKEAELLDYYYSSLKKDLVRFGAASSEKDVEERVFPREILQAQYEIALLDICRMVFAYAWRRWKAETEPTAASLNRNAYNKSTESALWLITRCHVLLQELEAKRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLN7</accession>
    <name>A0AAD2CLN7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLN7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="101"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1936385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="434" mass="50212" checksum="4CC753B7E7AA7897" modified="2024-05-29" version="1">MDEAKEEEVDIYHDSKGSSKTSVRKSLLIPMLGGNSAGFDGYDEFKNYALLDDKCDKYKKASKDGKRQIENDIIEHLEKQGYYFAKKEKKGDNRWYRETDAKRKQIKIKNLYDQVKKAETMKNLEAEIQESKGKIEKLEKRDLFDEYLREVMDSKIDLKFTDCLGRKGIFHGKAPASDQQFRGMMLYPRDYGIQMFQGIWTKERSFHRGILEYSNRAVYCGDFIGRNDETNDYRHGSGKWSKCHSLKFSETYVGEWQEDLRHGKGEERLVRDGGIELYEGNFEGDQRHGQGTCVYADGSKYTGEWFNGMRDGRGTEYSSDGARRDGIWVQNEHEDTRLNCEMSVDKVFGREITDVDGDVSMLSSKISSLGFPSNSNEDAKTRISDSKENHNRIESRNRNTTQSILSQLMHDDGSFPSVEDINVARKQYHPNRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLR7</accession>
    <name>A0AAD2CLR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLR7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1936595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="182" mass="20006" checksum="A49A00EA04FDF84E" modified="2024-05-29" version="1">MNNVILHVYELQPDTTSRRPHEISNTDRALLMVTGLLPSIGMGAYHTSLEVMELKYTFAANAGIMCGRANGPDVGVPNGAKGPVQSVNLGPCLRTKQELIQIIKKLSTLFYTSTSYDIMHRNCNHFTETLATCLVVHDPRERLDTYPGWLNRLANTGAMVITKNDNVVTSNVLAEARVASGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLT2</accession>
    <name>A0AAD2CLT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000754">
        <property type="protein sequence ID" value="CAJ1938678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLT2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="414" mass="47174" checksum="1C2E2955CC1F4A98" modified="2024-05-29" version="1">MGYKKITGHLVFDVKLGENFRRKARYSADGHKTEAPAALTYSTAVSRDSVWILLMIAALNGLDLQCADIQNTFLTAPAIEKCYLVAGPKFGEEEGKVFIVRRALYGLKSSSAAFRSHLAETLEDLGFSSSTADPDVWMRAAVKPDGEEYYEYILCYVDDILCMSMKAKEVMEGIGRVFKFKKGKIEPPESYLGARLRKKTLDGHNMWTMSSYDYVVAAVKNVKETLKDSPKWKIPKNEPTPMTSAYEPEMGGSSEPGREDHTYFQELIGILRWVTEIGRVDILLEVSLLSQYQAAPREGHMEQALRIFAFLDTFPKLTLYYNWRTPNVDYSKLRSSREDFEAYYQDATEEMPHNTPKLRGRSVGSTAWVDTSHGANKKTRKSHTEYIIFLNRAPILWHSKRQHINVIVTLLREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNP9</accession>
    <name>A0AAD2CNP9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000660">
        <property type="protein sequence ID" value="CAJ1937532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="18080" checksum="14F06B76CD96552F" modified="2024-05-29" version="1">MTATGTLSTNKRARFATDKTPQPSLLTTPSEAAECVAIAALTANGSLQESQRTYFRELFAEFIKLKKNLKNLNDRLITLNQDDYVPRSTKFKFQLHSSARLLEESKAEVDKVEHACNTAVALMQTTICDELKKLVKLDIASVRKALHCPQCCCYCNHTCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP68</accession>
    <name>A0AAD2CP68_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001005">
        <property type="protein sequence ID" value="CAJ1941430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP68"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="244" mass="27031" checksum="39077FBE9939F1A1" modified="2024-05-29" version="1" fragment="single">MSPHETADSPTKEEETLVFGKTITRKEASANAGGNLVTDPSALSTAAATEDPAMVTKTIASMGRPDIISLVDLEDEHDEHDLVPVHEYYCTPINPSSISISRVKSMTPTTATSVASSISSSFSSTPIGLMNSSSSSLSFYGAGGGGGDEQEQQHSSDAQQLEQHQALHLIQQESSYTYNTTQQQQQQQDEYELPRRRIPLSPRTKLQNWEVCLKPILMKYLHDEQLLYFYKLYHDHDIKSPQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQB7</accession>
    <name>A0AAD2CQB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050154">
        <property type="entry name" value="UbiB_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566">
        <property type="entry name" value="CHAPERONE-ACTIVITY OF BC1 COMPLEX CABC1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566:SF113">
        <property type="entry name" value="PROTEIN ACTIVITY OF BC1 COMPLEX KINASE 7, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042075951" description="ABC1 atypical kinase-like domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="407"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="917" mass="104309" checksum="D5F2CCF2986FB5B3" modified="2024-05-29" version="1">MTTNWMILHLFILTLSIGNNVIEGFNTRTISPFCSRLSTERSFGCYATTKERKVVEDDTTADKNRGDTVTNGAMEIVNGVNGVKEDKSSTSTSAQESTTDSLTAYNITQMMDEISRKINDGSMEVFENITDAMDERFHTVALTETSAQEMSEYITDLAKKMQVAQQRELQFQLEELNKRFLEPIEQIAFSDAPLFDMPSTPVKQKNVDEDADDKPLNILFGQNSTISMTSRMKTSEILNNLNVAPLYYSVALTLRYLRKASYPSIWLLSTFKGLANIFKSGSPKARTKGKLSYEEYIKDAAAMQSGWKRTGEIAAKGSVAKKWAILRRSLEVWAYFSSFYLKDRRIARKFESGKWSEEKFSEERSKLGAEITQNLLRLGPTFIKVGQLFSTRVDLVPQEYIEQLKLLQDNVPPFSGEIAVDIIENELGKPIDRIFDTFEKKAIAGASLGQVHIATKGGKTFAVKIQRQFLKELFEVDLGQLRQLALFADAIDVTSEGGLFDKNTKRDWVSIYEENRRLLYEEIDYTNELKNCERFRKNFDAPRFKHIRVPETYPEYSSGKVLCMEYVPGAKITDMEKIQELGLDPIDISIKSAEAFLEQLCRHGFFHSDPHPGNISVERAEDGSARLIFYDFGMMDKFGVQERKGFVDFAFAVYYDANVKDAANALERMGMLRTGADLDRVAIERVGQDFIDRFQSTLSRDAGWENELDPEEQRKINRERRTALGEEFLSLNRDSPFIFPPTWTFVLRAFFTLDGIGKTLNPKYDMTRIMLPYLKELIDLKDGSAIKTTLLRIGKRVGLRPEDINQLVTQPRRTANIQDVITRLEKGDFKLRVRALDVERQNERSKIVLKNTYEAIILGLLFQGGISMLTIGSGLKGARPLSRILLGAAAFLALRVPFNLNKLKKLDKYNENYGIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQP2</accession>
    <name>A0AAD2CQP2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="264" mass="29450" checksum="FADB6DAC213648DD" modified="2024-05-29" version="1">MKQPDVEAPSTAPNTPQRQPIVRIAGANTNGQIYGASNYMKAGTYGNVLLGETEFEDFAPARCVCCGCFVNDKMRKRTYYRVYENRFEYNEVNAPCLCFSKERCIGDYTRVHYFDQQPSRSANVCGCIPCICCGPPVVYYHVPKLWGCFDLRSCFGEGVYSSPCNCFDLRVFICIGRPCYQMWACRLARGTKNTEAFVSKWRGAVEEYGSSRGIPKEQQAVFRKNVDRICSCDYARTVPATHPADAAAAAGAPVAVTTGHTMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR51</accession>
    <name>A0AAD2CR51_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR51"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="324" mass="37205" checksum="9A0F58FF48D0C0D2" modified="2024-05-29" version="1">MRTVTILGRRSIQHGIRSWNRQQQQQQQSALLLPSSMLTSIQRVQSLPRKFSTDPQDDMSTTTAEKLQRFEDANPDRIRDIQVNPEGIGSQILPGNLVYKKYRFSGNTRKVPLELVHGYFWMMWDLRRTGHKTTLSNETLIPAEQAQLFPVLQGVQSLNDTKTDLPFFFVDDSPAAKKVTLLSIAFRDSGFKSIPSWTDPFQEAFDDNEKVGTLKLSITERLSLYPFRGPLTRVMKKNTPENEHDSTLVYFGTDVDDFRDVLRMHNIMTNYVFLIDDLGRIRFAGSGPATKDDVAKVIQFAKELAKEEEERSSRTAKRSKNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSH5</accession>
    <name>A0AAD2CSH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000825">
        <property type="protein sequence ID" value="CAJ1939675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="165" mass="19070" checksum="C2F63106C4B27423" modified="2024-05-29" version="1">MGDYQAAAERAITKADMFAQYAPSMYFVMSETFGRGLSLFAMARKTKKRSYEKEANAIRKQVAKWLKAGNPNVEHFYYLLQAEYEALENKHDNADESYRKAIAMAKAGSYLQCIALFHERYSEFLLHVRSCREEAAHHSREAATYFEEWGAMARAREIRESLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT98</accession>
    <name>A0AAD2CT98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Plastid division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS7938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000001">
        <property type="entry name" value="Cell division protein FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="CELL DIVISION PROTEIN FTSZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314:SF3">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN FSZA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="4">
        <location>
            <begin position="95"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="5">
        <location>
            <begin position="289"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1942420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="43281" checksum="B5E173AA2174BEBC" modified="2024-05-29" version="1">MFSVTAARIVPGLVSRRSLAPAMQQIASFRFSGHSTRKQSNVADEQLKSLMKNKAKPPVEEKPKEEKPIEFNETLIRKEETFPVDAALINQFAPKIKVIGVGGAGGNALNNMVTNKLKGVEFAALNTDAQHLATSRADTKIQIGAELTKGLGCGANPDAGRMAAEESREEIKKAVEGSHLVFITAGMGGGTGTGAAPVIADICYEMDIMTIGVVTMPFNFEGTHRRRLALEGIDRLAEVVDTLIVIPNQNLFEISGPETTFADAFQMADDVLLGGVKTVSELMTSPGIINLDFADVRSVMSDMGNAIMGTGVSDDPEDRAIKAAEQALGNPLLGLSLDISSAKGVLVNISGGSDMTLYEVDRAAQLITGKVADENANIIFGSTHDKSLEGKIRVSLVATGIDRLDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTI6</accession>
    <name>A0AAD2CTI6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000979">
        <property type="protein sequence ID" value="CAJ1940938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="166" mass="19270" checksum="3E2408A8A2FA03B3" modified="2024-05-29" version="1">MAQNKILYSAKLNENMQRSAHFETNKRTVKSNIMLKFVTKAMDIKVQGEAGFTTTLEDPIKLLKPIKRFMKKSADAEYGFLDFWEANQKFFAMKQGTTENLMHFKERFLRQAEVLQDLYGIGWFRNFAVKTKAYQCKTCCCLLAIVVRKNRVITPSKLPSLKDKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTU0</accession>
    <name>A0AAD2CTU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS8208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTU0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1942962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31557" checksum="4ED3A38B36D7838A" modified="2024-05-29" version="1">MSSKKNTMSFDKRNTMTSRKNATSSKRHTMSSKKNTMSSKKKKGRKLEIVFDPDARKDHLRGFSERKRERRAFGLAMQRVKDRKEKIEQRKQEKKDDLERVQEAERQKEILLEEELLNAGVLKDGDDDNNSQASVDIIKKSVDAKSEDLVVKQKKYDDEQAEKKWGGRVTVTTSLISLDDLSDDDDVEETQSKKKAVDHHQRKAGDVQKYLDQLKANMPGKRKQTRRLTTKGKNGAADMRGMGGSSNLKMAQKVLGKAKARAGGGNFTKKGKKTKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUD4</accession>
    <name>A0AAD2CUD4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUD4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042112593" description="Subtilisin" evidence="3">
        <location>
            <begin position="21"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="915"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1936668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="950" mass="104380" checksum="F43834574FB10DB5" modified="2024-05-29" version="1">MTNFAKVITITLLCASAAQGKLADRSRVVKARHEAGVIDKYHDNEIPIEGQSYRVNRVTGGVPEKTFSAANKKKNRRRAKEKKAPWKNLQGALGDPQMFSTAEAQLNRQDALEKQGDRKLSSQLTGCCYNYEGYSASDLCATYGQDCESGETPSHDSGDDGCEQEGLSFIGVSFSVNTAQGNPYSYQLNDQFPMENIIDRDYEFVMSMDEDGWLVGGGYKTFDPSGKMPYIDSSHTELLRIGNLNPDAGGTSIDQVYGAMDSVTFAPFSIFPEYLKGGGGHGSGDNDDGTVPSGDITLVVSVVETYEDNDSYSAYEYFLDNLFDALDSYGGGPCMDDHDTDPHVSMSRGVKFWSSYHSQEYAYQANLEVAVWQAMYPYGVPIGSGGSASFPPGGGGSKQYVGYGNLYFFFDRANITKAFNPNRDLSDNESYYATLYMTTDVSSFYSSTTSIGFDYQGSGDGNGNSWEHNPYSWSATMAMHDMTDGWDLPPNCLQEGETFFGIPLSRASESKMQSTSSFQEQFDFEYLTDRNGTYITSFGTNHGWLVGEELGNAVGSIVDKDTSHIPIFYTGTTNPDMGGMSLPDIIKVVQHIDFGTLYIKPAFVFIDEDGHAKLQFEVDTSSALAYLYDTLCKELGIAWNYDSPSNSQGSYTNCAMHAAGDRASYGCGPDGSNVGGYCPQMTLAYAPRFTSEDAAAAYLDKCNNYVDYWRSLYPSGVAVGTSSFCPNGGCLALFLNRLDVYEVFKPDLGGSWVEYGGASMPPTYSPAPTWKGGCDEPHNFHLDKCFRKKHKAKASAVAWDSLGNVGQFSVMLVLFMAITLSISIFLARARKKRRRGESYLGFFFRDLTRKKRKKRRRRVAAGMDNPMLDRSSSHGRRRSKSRSRSKSKTRSGTSRTRSGSRSRRRSSSRARDGSASRGRSAAAAPGAPEAARAGVFDLSNQEDDSRQQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUH0</accession>
    <name>A0AAD2CUH0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="196" mass="22103" checksum="6227CD28BDFB02F9" modified="2024-05-29" version="1">MESIIPTAEDLFLIVKEANKSFEKKVVFDTHVIKYGSESEFEPNEVSTLWYTKPEITALQTQVHQARSAIIRGEMTAQDIEKEGDLRGLEAYVSVSRLTHKRKVIAHVLEAQKTIKGNKLAKISHDSTTWHKKIALIHALQDYCDVHDPSLSQGIPEMPGSPPPMAKLPTLKRRPSSSSLSSLHSKRVRRRRLSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUK4</accession>
    <name>A0AAD2CUK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DOT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031151">
        <property type="term" value="F:histone H3K79 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOT1" evidence="2">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="427" mass="47082" checksum="A7FCCB6BCEC02DBF" modified="2024-05-29" version="1">MSKVAAQRRSVAKGKGSKATAARTISISPMEATANAIVTPVSKTPAERGKAKSSKSNARRTLFPASAPADSSAVLVSPQPKKGTIGGEDDDTEFAIMQRKRKSTITARPPAKRRLIFGKLVSIPEPLPNVRQVYKIVNKLTGSLGGNGYSGPIYGELTMGSMQKMIDLMMEHTHLNEHSRFIDVGSGIGKPNLHVSQYPGVEFSCGVEMEHTRWSLGMTCLKAILDEAQTQQQQNITADKSIRGGNCMFLHHNILEAKTFDPFTHVYMFSIGFPPPLWTRLSEMWNKSGRSASPAEPEGTQNCEYLICYHGPKAIIEDYEFDVELMAQMPTSMHGSKEGHMGYIYKRMTKSSAGKGKNSKDSGEKQKASSRRAIKCDPLFQHSFHLVQQGLNPLHEHVSQQLEETLGGGRRTRRSTKRVLTRASGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVD8</accession>
    <name>A0AAD2CVD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050154">
        <property type="entry name" value="UbiB_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566">
        <property type="entry name" value="CHAPERONE-ACTIVITY OF BC1 COMPLEX CABC1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566:SF118">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042218121" description="ABC1 atypical kinase-like domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="240"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="924" mass="101191" checksum="EADA6494BF7C9A23" modified="2024-05-29" version="1">MKLSAGILCVIAGLGNAFAPQSRGKATSSSKLSDIPTKLSFEATFPSWLVENANAASTSLNDLKDFKDTLSSQVSSDSVMMPVNVEETVNKILNSELFHLATTAWHLEAILAFGIGSALLWFVTTPEKFDDAPYEPGTTTYSPEKAAEFYAKRPLQVGKRVLKLAFLTGMFNAGVLFDWLVLGKLLKDEDYTALRRNEPRRAKVALSLCEKLGPTFIKLGQALSIRTDLIPEPYALELRQLQDAVPPFDSDIAREVLKNELGVSDLNLVFSSLSDKPVASASIGQVYKGTLVATGKEVAVKVQRPGILAEIALDLHVLRILTPIQTTLQNAANGAKTSPEDIQAAISLVDEWGRGFVAETDYRLEAENTINFESAMRKRGLDAVCAPPVVTELVRDKILVTEWIEGTRLDRDASPDIPRLCGVAINAYLTMLLDTGVLHCDPHPGNLLRTTDGKLCILDWGMTLDVPPNLQYALLELIAHINIEDYDAIPQDFINLGFSPEGVTADRLKSSGITEGLTFAFRQLSQGGGPKKIQERVKDEFKSRYGSDLSDEELRLAAREDMVQQMQKQLASEGVDVQGVSNIMEEVSKRNRDLFKLPPYVLYVARAFSTLEGIGLSIDENYAIVQECYPYLARRLFTDRSPRAKRALRAMLGLAEDADPEQTLVAMNLMETGNKSGALSPSKLFEMSDGFASYTAATANVDRDGAGQEAAVLEFVKLLVDEEGSTLQDILVEETARLGDAATRSALKAGFVDSAAAKVAANVLRTPRDLLQQSPLVSVFPKFLKEAIVDRPAELPDLIESLLSHNEEDERILSTATELRDILSSRLAAQEDREGERISSPNASLDASAIRELLADEKTRNLILEQVPGFAALGRRLGAGLLRRAAYRTDRAHALPEDARNQLADMNRRLAKALDVEEKESVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVN1</accession>
    <name>A0AAD2CVN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001379">
        <property type="protein sequence ID" value="CAJ1945360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="385" mass="42199" checksum="8684990A0043749D" modified="2024-05-29" version="1" fragment="single">MLDKANQTYAMEFKEYEQRNEYPTTIDQVAKALIKHKPDNRGKGPTTPRHTPRTNTASGSVPDGVSNAQANARTTTRTTSSRPAFSCWCCGDTGHGVTRCPKRSTRPQAEWNDPGRYSDTPTTTTTTTSRRAGRANLQVPAAASAAQSDAASSVTGTQSTGQQHQSNMQRAVVDRSGNGTSGTTDVPGSYVVRGRSVADGRSNGRITGWNLAQVRARPILKKKAVSTEDRGELLMKKWQAQLLAASTFKDDDSMVSDGSLNMQIYKSTLKMDSLKHCSQWTKDNKKPFKTNGSKHWDIDIGVHLDSGSTFSLRMNEDYAKPGTVSDLDYMFNYGTNTGQRDLHQQVESSIIEGHTCLLDTEAQCNLDSLSELVKLGFRVVMDTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXJ2</accession>
    <name>A0AAD2CXJ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="167" mass="19903" checksum="8D731468637A097B" modified="2024-05-29" version="1">MCYDHSSITALELRRCLEDHDDIKEESLFADDFRMSPFHILFSTVEPRGDMLEVLLKKFPYHVLGWKDADGKLAMDYLVSNWTYQNKILLQMALQSWIFGRLERWCDQSWRTTMIPLVNALLAEGHYRKLLHKSEEYSVPCDLLHHDKSMKIWRPRQSWKWPCGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZT6</accession>
    <name>A0AAD2CZT6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="63420" checksum="C97CE87EBBE489C7" modified="2024-05-29" version="1">MSKRGIDTLLTSQGKRLKTGEEIRFTLVKGPGYKPRADPVNPKAPKQQFPLIAKFPQSVPTPDLSTLPWNTARLFQQDIPKADEDSDDDANEVKKRWRPRQDVPKRQWILQEQVEFLEHMMLKSQRKPLPKDQISSQYSGIPEHNPSHFALFEVSKTDGQVIQVTTMAPPNTTISFSQPRGHKTLSMSEAEVAIQDQRGKMSRYMMHNKQRMLHNPSAAMPTESRKRLFGKLTKINKTDGDDDEDDIMGDVAFRNRKGAGRTRKELLDSVGDSGLKVDADGVLGGTDDGEFGKGQRFGRFKANEQTANEKSAQDTGGESSKGNDGNAMADDFYQRDVQAEYEELDYDVNEQFDDDDVDVGETEVAVEGAGFADEDEDDDFDEDGMENQIISGAEGLASVAGFRLLLAKARGEVTPEQIAESEEKRKKEEEDKKQRAAGAQQKQKQNSNEPVDHLTKIIAAAQDARVRAEKEEQKIAAPAPAAKDLVNKLDAQGQRVITIDSVRREIWLNHGTIKLKRLMKLFDIGKKSSKERRATFQQMVKELCTLENDPTGGRMLVLKQHYSNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBY5</accession>
    <name>A0AAD2FBY5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1895164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBY5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1895164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="200" mass="22025" checksum="428DEDA85F7197D5" modified="2024-05-29" version="1">MDTVVGVCYEGGVVIAADQSNGRSILTYQTNLDKIAKLSSHSMMGVSGPNCDLVNFTQYVAKNINLYELSNDGTKLSTKAQANFARGELATALRKGPFQVNVLLAGYDDKTKGSLYHLDYMGAMQKVKYGAQGYAQYFVSSIFDKDCTENMTEEDAVKIVEKCIKEIHTRFLMSQPNFIIKKVDKDGVKVLSFDADPADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCE7</accession>
    <name>A0AAD2FCE7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000136">
        <property type="protein sequence ID" value="CAJ1931257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="106" mass="11840" checksum="161F432927E0743C" modified="2024-05-29" version="1">MSNEYKRITIAQDGGVYDISNEKQFHRLLEWLDAKFLENSESKRRVTGYAALVDGGTYTVTSRNVTNTASSNAAVHPHKTTVEAQQPTMNHRSQAEAPGESNQEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCM4</accession>
    <name>A0AAD2FCM4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1921580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36971:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36971">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1921580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33705" checksum="BCEBEDBD261268DD" modified="2024-05-29" version="1">MSEQPETIEDKVTDWTTDPPSSNDEIELSNTPADRDSNGKEEDQEHEKEIENTKPTISVRQMRKLKNPQRKRHGARNQHKNKIFVKWLIDRFHLKTVVSDEDPISSSPVVLDVAGGKGEVAARLTMCHLQKVVMVDPRLADVPHCFDTLVYPKIPNKWQKRLDDQRKENPNVVQDKLANRFQQLVTTFDEYTITSNPELQSAIQNATLILGLHADGATEAIVDAALQYSKPFCVVPCCVFPNLFRSRQVENEAGEMVPVRSHGQFCKYLADKDQRFQTEILPFDGRNVAIWWDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEV7</accession>
    <name>A0AAD2FEV7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000491">
        <property type="protein sequence ID" value="CAJ1935646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEV7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="274"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="816"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1935646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1116" mass="124605" checksum="4E5B40AEC4F46367" modified="2024-05-29" version="1">MLMSARRLPNIVGWCSIGLFSACIVQSLKDDSKEETDAISKVRQLVPRDRIVGTEYNLLTNHPQHAFFDERRLAQSSASTSSESIDGEDLVSLKGSTYDPQKVHASGSSAAFVGMQLHVYHHMPQHLSDASSVVSGDECHEIEAQTTADIDQLGDENERLYYDSFVYEKAYQLIEPLSLELGVPPRHNLDFAYKPVIPQDKPFTQQLESDEKDDGTDSPPDTPWVDDDKKDPEKLACTDVSPTENVFSNWWKWWLPWSHNKWWQNHGSKRSDYKMGDSAFAGGSHGEIWKGHRICHDLSSTDCDDKKPLILKRLRVEKGYRLLEAGLREIYMGNWIRHELQEAQQSLYTAYVDHFFREIPVKRSFGLYQNTKLELWIVFEHAGGPSLRSYIYDTVTSEGGGFVMYQPSRLWSSLRSFRRKSDHQDSSLSVNLREGKSSQSDLQDANSNDQPKRELASRGNGGDVLRTVLKQVLSSAALLHENGYVHRDIKPSNVMCSTDTTPSYDWNEIPQLSNIKCRLGDFSSAWDNNYIAAHLYTMGPSPAEQTDEYAPPESYISDEWVPFDKDRPQSYDSWSIGVLALELLLGTPNVFTVDQRTTALLTNKMKKENASEEEIQRALYLAALSNFCIYMPGNTRNNNPKNNLSGPSTGRDSWPLRHGDPLHKTSISQQSCTMRDFHHALRARDPLGLGFDSSADLLLHLIWQLLAWDAKDRITAAEALLHPYFSSPDGSLFDSLEWDAPPATMFFPSSDPRLDFYPAAYSVDEFVCPKCGRSFSDWRSCHVHVNARKHGRFCTYDRTNLPTCINTHSMLPAHPTSGYCDLQGRRSVIEDFHSIQLDATVQFYGIFDGHTGNLASKYVASTMYDQLLAHLHLNGLSNLTKTDSLPTIWKEEIRANVSGAFAQLHEDFVERTSRMNGSTVDRSGTTATSLLVTDDVVVVSSIGDSRAVLSSINENGEITAIPLTKDHVASDPSEQSFVIEKGGFVSSVGGIDRVNGTLAITRSIGDVGLAPVLSRVPNVKIFTHYEIGDLCGANQHQSIPCFVVLASDGLWDVMSNQEAVEMVAIVIASYDATDRVSWNNGGAFQEAAEVLAVDAYVRGSNDNIGVCVVALLSGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG21</accession>
    <name>A0AAD2FG21_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG21"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1926628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="110" mass="12168" checksum="FB1063156328E7DF" modified="2024-05-29" version="1">MQPSKTNIYSGSFPNNTDDRSGDGQHDETHANWHQQQSLNVSSAPLAFLHSPIILSRGDGDSNASPAEQRRKWVIDIVDEALDVINGKYDDRESLLFNSSSGLSPNFPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGC9</accession>
    <name>A0AAD2FGC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000058">
        <property type="protein sequence ID" value="CAJ1928835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGC9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="120" mass="13329" checksum="AE15C9FD4C68574A" modified="2024-05-29" version="1">MLYSVCHGTNDWPVIKGYKTTENGRQAYLDLVAHYQGEGQLNKRRDSAYRVLNTTHNNGKKKNCFEKFAARVLGAFEDLKNCGDGMSEHAKVTKFLSMIKEGPQGAGLESCKTLVRGSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHI0</accession>
    <name>A0AAD2FHI0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000213">
        <property type="protein sequence ID" value="CAJ1932177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHI0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1932177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="264" mass="29757" checksum="3DA5CBF4682C4C5B" modified="2024-05-29" version="1">MYLHQIMEMNNEAAACIVQKEYAQGIEKLIFGVRQLQTHLVEMSELLDGNSADIHSDSPLDSWMYPAMEAIHSDSDASFFVYRRPLVVSPLDIGRARVQAENMKFYHQYVTGGNVNLVVAMLFNYGLACHLSHIDFEGRLNDGSRPDYDLLQRASQMYDLAITNLRRLAVPKSTERGSVVSDNIQFFRAAMNNLAIAEQTRYVMAASPIVGIPSNKGFERLRELLLRHPPASDDAPETTLWNCYLSNILRVTNSFQPNYCAAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ82</accession>
    <name>A0AAD2FJ82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1995 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053021">
        <property type="entry name" value="Chloroplast_ADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018962">
        <property type="entry name" value="DUF1995"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF1995)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509:SF4">
        <property type="entry name" value="DUF1995 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09353">
        <property type="entry name" value="DUF1995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042270831" description="DUF1995 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1995" evidence="2">
        <location>
            <begin position="72"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="346" mass="37961" checksum="EF9B6AA5ACE52ACC" modified="2024-05-29" version="1">MQFKITSALSVLLLVPSTFGFSNTAGVSQVSCSSQSLVTPNKSLHILQSTNDVDNEAKVLTKEEITESLYFPLTFDDMVKQTSSTMQAAYEKGMTRQTIRILLPRSTDSENLGQFYETDAENEMGDSVLVPPDETWQGGIMQLYRACSYSCQEILRQFTRNAAGGVVPRLQEDRSVDESGVDGIGLWLTQGSTPADDVSCFVQPAQETVSAIESISQQAGSRLVTLMNPQWRITDDALDTASRSEGAWGTFASFLGGKGGSLRKLEELGFTNVFVMEGYVCRGGNTRMMKRFDSDWAVFAENDAGTEFIKVGTSETRPTYQDIDAMLEEKGVALKYARDIGLAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJJ0</accession>
    <name>A0AAD2FJJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000478">
        <property type="protein sequence ID" value="CAJ1935475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="340" mass="37341" checksum="56EBC3F75C65640B" modified="2024-05-29" version="1" fragment="single">MVRIGQRELQALNIDTNITQLPATSSTQPSGTRVTMSTAGNSTTNRNPSRVLQPGHLETSLVYILETVFGYSAGSILHLALDLYGCKCYLNLVGLDDADIDGLQYPVSQPHDANGDPQPDVLWDVLKPLKAYLHGIRGYIYHQETVLQDPVTLTNSEEFDRGINLDANLYPTLSNNRQWDSPHGKHLTSEEEHPQYLSLAEPFVPDLESVDLGPEGKYGTLDKENSQYHRLVEPFVTDLASVDLEPDPVVDLKTKRQHGTLNLSSVDLEPDPTVDHKTKSRHGTPGDDHVQYPCLVKPVATDLASVDLEPDPLAYRACLASLATLPCKKSLCTAKLEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKI9</accession>
    <name>A0AAD2FKI9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKI9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041934913" description="TNFR-Cys domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22654" checksum="730DD2BBD60CACA4" modified="2024-05-29" version="1">MMACQSRVSLLSSIAALFFGIILLLDNAAAAAAAATDASSSSSSLSSSELEVSMILPTWNENAQERSLRELQLTQGKCWSTRDDRKPNRYCMFEDTPRSGAFLSLSCPTTRDDYSMAQCQCTIGIGDSQDAPNTNTCWKCGFCRDGSLAYDCRNVAEGTCIGRNCLDECLSSFNEPEDLLLGSDANKKASSFLLMVPSIIVSVFLLCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKY1</accession>
    <name>A0AAD2FKY1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="640" mass="73244" checksum="797DC08A2E0057B5" modified="2024-05-29" version="1">MNENAATYYAIKSCSRLHAPVLFFSWDDASQFLHSSTLSSTEYAEFDDMYHALEYMSSSDSSNESPIAQEAIPAVSTSCVARAAHCYNNTFQRPAEVWKATTKRSLPESERRIKRRKRNRIKDDLCATTKALSALNFDRSNGNPMLTKNNSNNSTMNNEFFLYTGQIHDDIPKTVTYVRTQTSLDFIPESTFRDLKQLGTVEIQKPVRVIGRRAFFSCRSLTEVSLPSTVKVIGDHAFRSCFPSGSLALPEGLETIGKWAFRQCEFRSMRIPDSIEEVTEASFSNCSKLLSCEISEKMIRIRDGAFSYCQRLRNIAIGKNTRTCKRGVFGGCQDLLDLFHSEDALVDALKHRFDALPLHKTCYYQSFSENVEIVQMLDMNSDDGSKQDCLGMTPLHILALSSRQDIQMYQNVIECSPSDLVTLDRWGEIPLNYACHNDIPVDILQCMLEGHLSMFHTEHIIWGRLIDILCSIGASREKFQLVLESQQRYSPNERLDWAKILETTLHMNANPETTRFLFECSIHRRLKQLGLEKWRSSVINEVAQIDDFSNRQACNEVVHEKLVEMERREILSLVEQSVWKDRMMDGGEDSMKIGYQEEEPSATRSNPYWRELCRVKCGADIVVSNVLPFLGNYLQQHPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKY9</accession>
    <name>A0AAD2FKY9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKY9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041953813" evidence="1">
        <location>
            <begin position="19"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="462" mass="52791" checksum="C27E25D700255540" modified="2024-05-29" version="1">MLTIFLWLLLLTIGDFKAALCFCRNYESATAKRHYFSVVESSQYSFDETHSGINNDKFHKQDGNSILGTVCVDYSAANEYIRAHYGDQSPRLPLYFEQEESIETVHDARCGVPCTTTAAATTTTNKENPLIGDDTTTNTVASLKTCGFTLVSPPAISPEDVQQNNWNNLEWIQRNRLPQWRKSLKQLYNHDAPNHQRTIRHMLFWNPMLRGPPRKPITTTTPYNNDYGGNTESFSSTPKASYAALPHIDMDVNAYDNFEDFLDLMENNEVEILDASDGGTLSANQERIRQRRQDILDSIQNKHRGFAIVNAWCNVGKHPVRKDPLGLFSVQYDDDKTTSSIAAFPMAAPNMNKSHWYAFSDMIPNEVLYFCQYDRDTSWPSDLWHCSLDGIVTTKHQGQQTNLPPRESFDIRCLLVFDEEVPLEQDRFQRANRLSSLLSLEESGCFCEGQFEERRREDGVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL66</accession>
    <name>A0AAD2FL66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000802">
        <property type="protein sequence ID" value="CAJ1939510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL66"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="44605" checksum="0341AD1DFD6BB161" modified="2024-05-29" version="1">MNPPPTAPMEHIVPLPPDYGNASAPLSSHSASHDKHSLFSDYQIQQLIKQGFTKGLCTALEDAKKVFALRIWIVDNSGSMQQPDGQRMVPNSKGNNNTIKMVPSSRWDEIVDCVEYHAKLAGLIEAPTRFRLLNNPGANVGPQQFSIAEEQGTSSSSSITREIGQATSIMRKAGPSGCTPLTSHILEIHTEVSKMAPTLRRQGQKVAIIIATDGLPTDERGYGGLNHNQEFVEALRMLEGLPVWVVVRLCTNDDAIVNFYNDLDGQLELSLEVLDDFCGEAQEVINHNPWLNYGLPLHRLREFGCHDRVFDILDERPFLKSDIRDFFALLFGRENFDGMADPLVDWDAFVQQIAHLLQTESYQYNPLTRRVSPWINVSRLNWIHGRTKCFPANNCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLD5</accession>
    <name>A0AAD2FLD5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS6979</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000407">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="613"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="384"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1940312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="697" mass="76824" checksum="1D1C14F3D24F3879" modified="2024-05-29" version="1">MDQAPIQIGQFILGKNLGIGAFGKVKEATHVVTGHKVAVKILNKAKIKQLGMEEKVQREINILHLCTHPHIIRLYEVIDTPTDIFLVIEYVSNGELFDYIVSKGRLSADEARNFFHQIVSGVEYCHFQKVVHRDLKPENLLLDENLNIKIADFGLSNLMRDGDFLRTSCGSPNYAAPEVISGHLYAGPEVDVWSCGVILYALLCGSLPFDDESIPSLFKKIKSGMYSLPTHLSQLAKNLIPRMLEVDPMKRITIPEIRLHPWFQHKLPPYLRHPPELMEKQERVVDSEVIEEVLKLPFHKAYGTISHSGSNHMLDGGVNMAQHQFPQGVVTRELVERAAALEDNRDSGTPKLLRDLRCAYELILDHKHTRLRVMEVARAIKEATSATPPAFSPGGSRGTTPGGQYGGMRYSSSGGSYDGRYGGAPYSSSQSPTALNSNSPSNQARLAEEATRALMQPGAGMQQSQQPPQSIGVSSHPVVQMTSSIPGNTGMIAQHQHGRRTRRWYLGIQSKKDPAHVMTEVYKALTALDCEWLQLSSYRIKCKWRPNSESARLGMGYNTMPSAGGESIAAAMDTDGAMDMDVEKDKKRTGGARVSLMKVVGGENGHDVPVPILSTPDYAIKIGLTLYKVQQNIYLLDFQKKTGDAFSFMTLCANIITELKTLSAASKQQALLAQQQAAAAAQQQAMQQAGFPQGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLD7</accession>
    <name>A0AAD2FLD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS6994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="7">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="6">
        <location>
            <begin position="155"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="8">
        <location>
            <begin position="386"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1940342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="502" mass="55419" checksum="69338C526EDD28E3" modified="2024-05-29" version="1">MAHAEAPERQRIDPLAVVKDYATVPRLEYRTIAGVNGPLVLLDNVKLPKYAEIVNLTLRDGTTRSGQVLEVAGNRAVVQVFEGTAGIDNRKTRCEFTGDVLKMGVSEEMLGRSFNGSGKVIDSAPKVLAEAYLDINGQPINPSSRDYPKAMIQTGISAIDVMNSIARGQKIPIFSAAGLPHNEVAAQIARQASLVQQKDTMDSHEENFAIVFGAMGVNMETARFFRSDFEESGAMQRTALFLNLANDPTIERIITPRLALTTAEYLAYERDLHVLVILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVVGRNGSITQLPILTMPNDDITHPIPDLTGYITEGQIYLDRQLHTKGIFPPINVLPSLSRLMKSAIGEGMTRSDHGSVSNQLYASYAMGKDVMAMKAVVGEEALSMEDHLYLSFLERFEGKFIAQGPYQARTIFESLDLAWSILRAFPKELLKKIPKKTLDQFYARRREAAEAVNKADGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLM1</accession>
    <name>A0AAD2FLM1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001079">
        <property type="protein sequence ID" value="CAJ1941794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="16540" checksum="659AA9E621A58F0D" modified="2024-05-29" version="1">MKVRMNNVKGVPGNNYNTPSTTKQLIERWTLCGDESMLTLEREKVMLRFDIEIPTCDGIVFRIYIKPLTNDDVIKHVVNHMLGTYYTAQTGEDPLGCGRAHTQIPPMKSQDTTSWASKGVKAKQCQDHCQVSEAAEGETSGTATSETSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM44</accession>
    <name>A0AAD2FM44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related protein Rab-7b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS8958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000751">
        <property type="entry name" value="Rab family GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1944579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="233" mass="26000" checksum="6F3B0B45CC7D1A3E" modified="2024-05-29" version="1">MQKKTLKIVIVGDSGVGKTSLMNRYSSGKFTGQYKATIGADFLTRDNVVVADYYGINHLVTLQIWDTAGQERFNSLGTGFYRGADACLLVYDITDPHSFDNLNHWRQQFLEKVGGGLMGLTDSSGTFPFVVLGNKSDKAMERLVAPEQAEEWCRNASGATIMGSQPLPHFETSAKTSENVEDVFVEAARRALIYEDYKKRSQPQLFIPPAQEPIDLRHQTSSVRIENHEPCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMB8</accession>
    <name>A0AAD2FMB8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001374">
        <property type="protein sequence ID" value="CAJ1945355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMB8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="104" mass="11878" checksum="E39A8B19D53A62C6" modified="2024-05-29" version="1" fragment="single">MSTEESSASASATPTNELEKHHGDDDDGNHNDNNETENHKDIDFLQAKCSLLKNQLAFLRSQQKQKKEQRKKEKGEIVSTFKSMKGYIDNLERENKQFKALLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN26</accession>
    <name>A0AAD2FN26_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS10807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000010">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF94">
        <property type="entry name" value="ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1946726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1218" mass="135946" checksum="1304EF3D382AF38E" modified="2024-05-29" version="1">MSATSATSKVVTEGGALSHVNFRVRCETLGHGEAVYLVEEGDASMQKIIPLYTTAAAYPWYHTLQPLTIGLPRNEQDLKNPNNHYFRYRYAVHRGGKFHRYENESDAPSQKDVGGDSDTAMDIGSEDDEKNDDLIVYHQMPLRLFANRESYVVNDVLGKTTGPPDIDHIRLETHTSEGRTSSIASMHSRNASFGQSTSFTGISNKGSTSTLKPASSARKKAVGFAPPPPPYHRPKAAAALQNIHLNSTDGLVVVSAFLPVVLHRTDAGKWSADWDYEALLSMQTHLRVTRIGVVKWRGWHGNFGMTDKKHASPEAAGVPVNERHLVDECLRPFNCVPVWMDTKVFGEMYNGFCKSVLWPVLHNVTSVYSTQKDLKEKNPGGDFQNSDQEQFSEVSMDDVEKGPIHGGHGRERELWSAYNTVNRKFAEVVVQHFNEGDLVWINGFHLLILPSYLTRRIPMAKVGIFLHTPFPSSEIFRTLWCREDLLRGMLNADQVGFHLFEYARHFLTCCRRLLGLNYGMIPDASGGHTLAIDTNGRHVAVTSIHAGIEPHVLNQVVDHVSTKAEAATIRSRFHGKTVFLAIDRLESLKGIPLKLLALQNFLKQYPEYVGKIILIQIGISAFERGSDYDQTKNEVEQLVKRINDKWPGSIQFQECSESNMRLQQRMVLMRAADVVVVTPIRDGLNLLPLEFTMAHHDALTPAGLADKRKRGLCILSEFASCTRVMRGALHVNPWKVSELATSFHQALTMTDDERTRRVQCSIEFVSRVTTQRWALAVLMDLKGVQKSHNPIQYSGAGLGLGYRILGMDVGFVSLDFSKVAKAFKNARSRLILLDYGGTITANDNLDSLYRFKMVKERKTHSNPTGAMINTIKELCADKKNTVFVVSGKERHSLTKLLGDIPRLGLAAEHGMFISWPTPKASEKRQWETLVPITDTTWRALASAVMEVYTSRTHGSYIEETEMKVLWQYRDADLEFGYVQARELEDHLSNVLRSFPVDILHGGVQEGGYVEVRPKGVNKGMLAMKVIKNFPSLSQVNKVEFALVLGDDHCDEPMLSVMRQIGRRVTDARLLKKGDDPLPDLPASLTLVDVSGCDDYLAPNLEVFTCTVGKKPSAAANYLRDVTEVQELLDALKKAASRDQKYYSAVNLQDFSQENTAVQNTLHRFDNTLAGASIKRHSSLGSLSSGVGMYGSDQKVSANLGEYLGGFDDVAEEDDNIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNL2</accession>
    <name>A0AAD2FNL2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNL2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="406" mass="45142" checksum="9335B857AF2961B4" modified="2024-05-29" version="1">MDGLDDRAQATLSSIVEQLYTSETVQVKHKQIDQRPIVARRLVLRSGISIQGLVWLQEALLYNHEQQKRQDRKVKQLFRIEALEVCSLQDTTVLAKVFKLCRTCNITQLTLTSYLSYSRGRHALVAQTIRSGLLGIDLESLPLEEGPNGSNNNNLGFYDPMTGQHGETQQALDRTRTIRIGNAPSTTNLEYLELRQYPIGAEGTKIMAAFPVCTATPTTSSSSSSQLKIGNGGLHTLKMIDCDLQSDCAKDMAKMIQYSTNLRVLDISDNRSLTGASLVAMEMFLKTLVKHGMQDNLSLVQVDMDGVDPRKLNRKRLNRHLDINRLLWAYSTLTEPPPPLEGTAESSPSTDDVGPLHPPPIPRVGEDTQSVYGLHPALFCQLLGRVSIKPAATYYFLQQNITTMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQD9</accession>
    <name>A0AAD2FQD9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQD9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1949243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="43360" checksum="DC09285605483CF8" modified="2024-05-29" version="1">MADLNHEGASTILYNTEYLTLILGWLLPEEIMNCAPVCKQWSTGVSQTWKRFLQNISPLLYEATVNTINKNEQRMPPEQIFKQFALREYKLRQDAYCIPTETTISYRNAVKERALKRRHKEAMSIVHKQGCSSESYCPPGLKLEDVFLVLHLYHAPTRTRMGYAIWNLNDVMEDGLIYGKGSPILMKDIDFQIPIGSFAEHEGPLPATASNSPRSAFWQKCVATSLDELGVEMIKTAIVCVQMYRCDSGKTLSFERGQMMWAKYERLLGLVRTDLQKSWTNPNPASFPLPDEDDQYFDPNNVNPAMSKVSKQYPCIGFEIGVAKVAPMNVSNFTPANKGGRMTVEVHLSMYELFPGHHRTTIRWKEDLRKHLQFMDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS52</accession>
    <name>A0AAD2FS52_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001782">
        <property type="protein sequence ID" value="CAJ1951475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS52"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="653" mass="75091" checksum="08047B0AC880AD64" modified="2024-05-29" version="1" fragment="single">EEHQLETGTSFGLFQQDYSNTAILASDTWLKRVWKELEDLDICVALDTPVLPLRCESDALLIEVFMELEVDQDALKWLNWCRMFLQVCTVSDIVTADGRSIRESIWHGERDYTHRSSSQWPHTVRPNRNHWRVWQENLTRALLVSDGTQRLLRHPLGPWFDPINDWNWLWSSTHGLFHRQGHGWQHYRHRRSPTRSLQWDYTRPAQLSGRKRPHNEPANNGACFLSAPFWTHPLPEDVSEVTEYVGWTPEEIEIDGDESLLAEALLEDRLCVISDGSYKLGLGTAAVQLLPRKGVTERIIVCCQTPGLPDDQSAYRSELIGLLAGILIAPNTRFFTKLAALYIGDVKQSRLNPEHIQELVALPALRKRWHERQTITPEAELETDWTSLARAMSSLPAGVQRRTTKHVVGMCGVGKFKVRWGSADSAACPCCGEFEDHLHVPRCMAPSASAEWDRRTVTLDQWLDAQVTDPAIKHAILHLLQGVRDPSLPSSWVVPARLCSAFLSQQCIDYQGLLEGRLSVQWAALQEQYLESQGSQRSPTLWVSRLLHQLILLGFHMWEHRNSVQHLEDNVQLRERSRLLNDGIHSQFDMGPIDLPKVVQRMLAVKRRTVLNTPLVDREEWLKLVRMERTAYRRALAPQRRILHRFFHPAQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTJ0</accession>
    <name>A0AAD2FTJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Golgin-84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS13095</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001782">
        <property type="protein sequence ID" value="CAJ1951483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000301">
        <property type="term" value="P:retrograde transport, vesicle recycling within Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019177">
        <property type="entry name" value="Golgin_subfamily_A_member_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815:SF7">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815">
        <property type="entry name" value="GOLGIN-84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="701"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="437"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="554"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="626"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1951483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="819" mass="91876" checksum="B297A31145A0E3BC" modified="2024-05-29" version="1">MSRWLKSVNNLLENLDGQAENVDIDGTIGQLIEKGQQVAKTLQRDDSFDGQSHDDDDFLEDEEDFEDDDEDIDFTDNECNDNTFDGNCSHVKGEPSSKHDDIEEEELSDSILQEKLVVGGRAAIGTSDCQASIHTDSVSELSCTERSEKTDAAELYEEQYNYDRNSNQPGRTDSYRKQVVPPSDSVSATVSKIASKGQPRDMDVSPRPPRRSADTDGIKRQVAAAQLEAENDSDGASSKHRNSTDSHAPPKPPTRQSSISLPKTQPVSFVQTSTLDGKQKHKSKTISNVEMRKLTAKVQSIQDRLTQTSEELKTSQTENRKLEKQVSALASQLEAANSEIHAQGEELRRAGERMEKDRRLAQEEREELLDDQDEEVEQLKALHTTEIEILKASYEKQLNDVTNKLDSEEARRAQESGSWTKELDDSVKREREALENLSLAEMKQSNLELDVSKLEEKVKGLQSKLEAATLCIKEAETRQGEAEDKLDVALSQHARQLNLRQTREAELEKTILDLGSALTETKRVYHGSTIPSPEALPSDGTNFKEKYDAALEESDTLRVQLNMETQRRAALEKELNEISKERSEEISLAQAKQLQQDRKVADLETNVAHLKSSLHSLKVMGSESNLEKNRRKKDVSSAEIEEARQEIAKLSDQLMRQQRMAEASKSEVLALKGRLQSATSRAEAAERSLFTAQSSSDYPARRSFDVENAGSSSSRRRMKGARRRPVSMGRTIRASLHLDHGALGSIMEQVVSTIDALDKWMVETGGLMRNEPLARLGFLAYLVTLHLWTFGLVIFHTVETPHGDFGTMDANPRHWRNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTL7</accession>
    <name>A0AAD2FTL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTL7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="3">
        <location>
            <begin position="178"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1952811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="598" mass="65879" checksum="0399F3533B9DF006" modified="2024-05-29" version="1">MRGVGNGNNEKDKLEKFKKDHLILPNANLQRQKVSIDGTVKANGRMYSLNDLQPLDVYSRNAVIMIDGEPRPLEDGSHRIRLFKSKGDQGETMLVAKEGYFNADNGGEIKSIDIISQDGSEVLMEALEDGTLVTIRPEDMDQNKLRSLDFGEGNADIITNQLMDRNKRFLQERCNSFKVVEVAVAYDSTFCAQAASNSESTARTLVEQAIARADTLFEPICVRVRLSYLEGFCSQAQDPYTSAANAENIGCDGNRGALQIFRDYWESSRTNVNRDVAHFFVGRDFPGSTIGCAATPALCDDVSYGIDQLSFTTNTQLQGNLFAHELGHNMGAYHVSDPDNASEFLMESSLNSGSDGVSSQSSNSILEYLDTRSCVSTEDVGNGDDTSPDPTSGPTSAPSRSPTTPNPTTPNPTTPNPTAPNPTATITPAPVSNPPTSPPVDPPPGDDDTNNSFRLENFKHRGYCVTVQEEEGPEAAFQNRQQNTTPIHLEPCDDASLAQSWIWNEETHVMQSLLGDNNKCLFAMNHAANRAPLVLWDCDSDLLFYAQWSYDSDDQTLRLDFDTTRCLDVQNGNQDRTTTLQMWKCNNGAKDMKWLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUH1</accession>
    <name>A0AAD2FUH1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001829">
        <property type="protein sequence ID" value="CAJ1953534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="302" mass="34420" checksum="3DAA4828C9E8F4F9" modified="2024-05-29" version="1">MEDWATSSRSQAGPPFPFHKSSYPFDGSKVDSTYPFQASDEELLSVYAEERARAQRARFEESKEETKEEDDDLDYRFQTSFIRPGSEQSKEGTKEGDDTLDNRFQASFIRARSVESNEETKEEDVEMDTGSTQCLDYYEEELEIDPTILPTGSANFCIVNCESCTPPPISWIIQAIYSARHDLRFKLKTPQGAHMLLYADEIIDCVLVLIDEDDGSAYFQIEDLYGNILFADCDQVEAHILYIISTETRKRQATVEHATMDHETFSHHAKPKRRRKHSGPLVSGLRKLSGLVKQCRTSSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUR6</accession>
    <name>A0AAD2FUR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13369">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13369:SF0">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="402" mass="45453" checksum="FCE45060B2A99296" modified="2024-05-29" version="1">MMMSQSEQKVESGKNKRKEILDDPSSNAQEEPPVSKHRLHKRRQRKRNQDRKQNALTELMNRMIESMDGDPSASKVENLYSSIPLDPNAKNHFWSKVPCMCDPCRAVMDKAIADDPKLDRDKKYQTKYKKKLAVMQEMGKITETEKEEMWTKHGRGMDDTAGVSLLSARRGQRKAWQIENFAFLLTRILKKRPANNKPLTVVDFGCGSGNLCLALAAYFENVRFILVDMKPYPLKLAERRSKEAGLTNVEVMQYTFSPQNLNDFCPTLDANNAGSGNNEVVAFDVGIGLHCCGSFTDMVMELCLRRGATCIVCPCCNGAMTSKTTGGYQYPRSSSFRGIMSQDEYLGQLSKSADDLGNYEAKCLIEYDRALWAKESGFKEVSMWKLNPTECTPKHHVLCLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUX0</accession>
    <name>A0AAD2FUX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="54"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="286" mass="30902" checksum="82FD47524EBB445C" modified="2024-05-29" version="1">METADAVRQVEEILNLQDRWFAKDGGVTIQTPALFSRLQKVAGNASNMSSNKRLEVKKQLALDIDCSILHPDDLSDMILEVEFPSNYPSTSPCHVRAVKASNRESEYVPCSAAIEAYLQPFAGCECIDMLLDWLSDNKSTCLSKGPGGGDISGGRNDHEGQALCYLLRYNHLLSGPEHKKEKAMIAAAKKFQLQGGLLWGTPGLVVVVPPSTEEDAKEYASECRTIGKRADGPNEVWLPQSGLDEAGMGGLAQQKRGGKLQELDTAGLRIGCGGNESLLKQLLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWH4</accession>
    <name>A0AAD2FWH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent transporter ycf16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS15356</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000082">
        <property type="entry name" value="ABC transporter, multidrug resistance associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="913"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="126"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="459"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="784"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1098"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="705"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1954764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1358" mass="149823" checksum="EE9E6EC8B127757C" modified="2024-05-29" version="1">MCENGRSSNQVEEAKTTSKADLSRWPEDPDKTSGCVASPCRFLLRQYQNWTFAYMGAVLQKGARQNKTGGSNLSQSDLYVVPKAMRSSVLVQLFEENYQKFQSIDKDDKRLIKILWNIAIPTYIPAGFCELIVVLCGTGLPLLVRELIRVIEANPRTKIVDEGMPFAISIFLVSVINGLGNNRHRHLALKTGVALRATLVSLIYDHVLQLSPEGKQSLTSGEVTNLVAVDTQKLYEVAQDGHLIWALPLSIVLVSIFLYRTLGPSIFIGIAVLICFVPLIQKITEQMLKARGKRIKFTDERINLVSNMLQGIKVAKLNNYEENYLQRVTTARNRELKYLRTEMAIWATTLAMTVVSPVLATAATFIAYVYIDESHILTASDTFGVLLLFSALRFPINYAGRLIGKLAQALSAVQRISQFLARQKRSNQKQITNGGHVPEDSTRASAPLIVSQASFRVGSTLSDIDGTEEGVVDDTQKEDTGFTVTDFDFSVDKGEVLCVCGPVGSGKSTLLNGILDEAEAIGKSAVVKEGKVSYVPQTPFILNLTLRDNILFGLPLDKERYERVLDACCLRTDLEQLGEAGDLTEIGERGVTLSGGQKQRVSLARAAYAKSDILILDDPFSALDSGTGRIVFERLLLSKDSLFRESAIILVTHGSHFISNKGVDKILVVVDGANRFLGIWEELVTFEPSDDTTKRAVDHIRSTVREDNTEAEGGDEEVKGDELSKETSNSKATGRLMQVEEREHGLSSTKTWLLWFKRAGGAKFLVLQVIFMAIDRTVYVATEWVLARWTSATVNPVVMLGWEFPPQSDGFSAQTEYVKVYAILLVTMVVAVTVRSEWAVTGGARAGKHVFESMLSSVLMAPMSYYESQPTGRLLNRFTYDTEVNDVVLTQAMVTLMISWSWYFAGIAIQFTILPWTAAAIVPVSVMYWVLALHYRLSGPDLQRLDALSRSPLQSMVSECLEGSTSIRVYHQDKNFVDRFQSIVDSNSSALLNFVSAQRWLGIRIELLGSLVVLVSSSLVVSLNDVWQLEAGMIGLLIMWASHFTITLNFLVDTFAEAEAAITAIERVDAMADLPREKPMKTAKEFEVDQEWPRTGSVSFEGVSMRYRKGLPCALNDLSFQIPAGKTCGVVGRTGAGKSSLTVALFRLVEIESGRIMFDGVDLGNLGLSDVRGRGMSIIPQDPFLTGDVLRDCLDPFNTHSDEDIIEALKAVRMGGDTPEENAKILTSHLEEGGANYSVGERQLLNLARAFLSQPKLLVLDEATASIDGETDAFIQNMLRSRFPNTTLITIAHRLNTIMDYDLVLVMDAGRAVEFGSPKELLDNADGIFSELLDATGTESSLYLREMANKAVTDGDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWN8</accession>
    <name>A0AAD2FWN8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS15433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="403"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="786"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="971"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1280"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="824"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="852"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1039"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1059"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1298"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1954841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1392" mass="155712" checksum="25D47F4E48E18128" modified="2024-05-29" version="1">MKRKAKPSKSSKKGSSSRGSRAKRSKTGIKLPRESCAPSSSDSEYHSDPEHYRLNDTRPRGPESARLPRELCVSDFKDGTDPILHDFERTGREKYFELNGLKRKSTNSEKGSEKISANEKIETSLVATETSDSAKDDSNGEKKSSSRRRSKSPSSDLLQSYRRRSSRRSEGAAPELVSLSYIYPGKMDWDSFRNCWVKKGTAAKAKPKELATKKSTAKSAPAAPTVKVEPPAPLAEEKKELERKSKAVEETKEEAKEESKEEAVEEAKEESKEEAVEEAKEEDSQPVINDGDENEKDSRKLSPPTDEAEKETKETDEKTSVEATKDNALYQFADPDEDEDSVEVASKTAALKGDENDGHGSDKQSPSAPETNDSNNSAVDKDTTEREKNQETIVVNPADVNINDFCFVCRLDGDLMECFAELENGTEAGCGKSIHIGCIGRAKIPSKDWLCSQCARKQGLQIKPGEHPQYGYAFGEDEFEVENGTVVIKLSLGSRIAVFWRDDRRYYNATVVNHYGESNVEVLYDDGVRESLDLSDERYKVLPNDDTAIGSSEIPKSADEERKVALLGPNDIVVGRGDSQKGWANQQHGYHVFRKLLNTYHTQYEALSNNDTSDRRTLCKKVYSELDSMNFRFVSWDGNGWKQLAYSKGVDKVNQGLRDFRVGSVLNNGNEKDERGLRWNDVPLGYSTKKGLAYRPGYQTLRRIVRSMEVEFKASDDKRVVCSKVLNRLAKEDVRIVRIVKKDGGDDWVQVEKEKAITRVFRAFQEESSESTYHVVSRAQGVMPSQQIHIPPLVSPKTRDRDRSKKIRSKKSRKRLPASNKLALDNRHPLIREDPSSKRVSVEIDPTFLVQSDNDSVASGSSDGSSESSIGSAMNQIDLYDEDFENANIKAPLVNLCSKIRVGHLAREDRPTSSHFDPAIGHESANYYYQPPPFQRITKFSYQHDMICDLMYSGPPGKPPMLAAAHRNSRYGSHHSVPKRSSNVTARGVAWSPPPVQATRPTSQVPRALPKVAPTSAMTAVYPHFAVAGALAAATYGRLPPPPPPPPPPPIASAIGGSSRKRGKSQSPRKKRKKTPNLGSPNSKTLGKPQLSAHAIAVLGKAAIADNDDHPVRFRNYQVETWTARLQEAQEFRRKHGHCIIPHDYPENQELARWAKRQRYQYQLYKNNSAKSSMTTERVKVLEQLGFCWEHKSTIWHKRYAELKGFMKEYGHTLVPTNFWNRKLASWVKCQRRQMRLLEKGSPNTLNDERVTLLNAVQFAWNINSADIPDIVANTKPMATTAAGRGRGGANYPGSSSGEEDDDEEYDYGYDEQEEEEAPPPPGPPGMGLEERKIRAKYLKKNTSASSASAAASLPPGIGEEEMKIREKYKKTTNFTEIGEEELKIWAKYKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXA5</accession>
    <name>A0AAD2FXA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Folate/biopterin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS15720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1955369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="81735" checksum="789025BB91D7F0C8" modified="2024-05-29" version="1">MKDEHHDMATGISGPRRTTQEPLETAAANAEASRLADLYGVSSTSKRGPPFLRDNASPIASKVSTPMVTQRRGFGIRLFGKKSNVVVEQGVTEDYQALSPDTNPSGVTTANSERKSQPSLASVYSPPPRVKCGTEDEVHNKADEHSVRTRTFSVETGELAAFDANGNLAPYRDGPYDIHHDYYGRQIKRRWYGRLEDGYLAWSSIFLHENFGFTIYTPLTEKEEEKMRQNEFIPDWMEYFTSLPNLAIPISYFCIGVALQLLRTPLIVYFIQDLGASAAEVNVLFTVMAVPWCFKVLYGFLSDCLPISGLRRKPYFMAGWVVYIASNFALSAATQPSIGMCISLVFVQTAGYMLADVMTDALIVERSRYESEAARGTMQSRGYIVRFFGSMIGAAIGAVVYNKDTWEWFLPMPLIFFINGAVPLVILLPFVPYLLELENHCKPKQFWKQCEELFETVQLRSVWQPMTFVYVYNALQLTNAAWMNFLVEGLDFKPWMIGLVSVVGSIMAWVGIITYKKFFFASNWRVVYFWCTTLASAIALGQLILVFGMNRPIMIPDIVFSMGDDVLVEFVIAVQFLPMCIMYLGLCPPGSEGTTYALLTTWSNLAGSLAFDISTALTAIWDVSSETISEGDFSGVWKLSLLCGLLGPLPLVLLKLIPKNKEDQQKLQKDETRSYSAGVVFIFVMIVTLLITFVESVYEVASDEDNASMVADGMEGGDGVQRRLKRLLIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXL3</accession>
    <name>A0AAD2FXL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS14950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042085358" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="29"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1954358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1316" mass="144372" checksum="12EE1E50F94C8E41" modified="2024-05-29" version="1">MMLIIWTFLLLTISAAIAERNLAKVSPRIIGGFDAKQGRYPYIVELVNPDGSPRCGGILVATDMVLTAAHCSGGLGFAYIGRWNRDSNEAYDNFTMVEMEYIHPQFVEDLATSYDFMLLKLTQQSSKAYIKLNENPDIPTGQRIDEVTALGFGTISTNLEEYPSTLQQVELTYINNNECEKSKDPNYADSYQGVISSDMLCAGDFGQDTCRGDSGGPLIVDGGSPDKDIVVGIVSWGFGCALPAFPGVYSRVSHEVQWIKQTICYVSENPPTEYDCSLYTPPVDGENTVPVTVTLNLDDFPEETGWSIRNKAGGTIYGQAKPGDYTTKRDTVIETVFLPAGSTCIFEITDIFADGMCCNNVPGTYVIMMGRAATGTVIATGGDKFGASQQHELIIPTDYNESNGPVIGEGQIAMTLVLQLDNNPLENGWRVDQLGGVESNEVVRVPPGAYRTPRAKIVRTMALDEGELYAFRVSDLGNDGIQDGYVQIFLGTTNIKDESRMIFENNGDFQGSLDFSFISSFDTDPTSPPRLDSEFFLTLELRLDLYPEEISFQVRANSDETVLSRQNRDDSVIFFRPPRFYSDKARQTVTEIIPLPTINSGTSRDFTFIISDEHGDGLCCNWSGSNGELPGYTMYERGPGLNKVLFGSNMEGTSKEVHEFTIEGPPLSGEKTLSPIESLPTVKIKITIALDGYPTETGFAINELSGKRVVDRPSGSFSSPNFLMEEIVTLEIGVYEFFIFDSFENGLEGQDSFYRIDIVDGQDRAPIVRGSGRFSTQESRVFVLEGETADAPLDIEFTLDDHPSDFGFFLKRLDLVAPEAFVAEVPPGYYSGRNQKVTESLKIRKGGLYIIVFEDAGRDGIGGEILVNVGSKLDGKTYSIDFSNQQSWQLKFLVGVKPATASGGKRLELKVKFDQFPQELEWILVADVNADLINQGRALQEQQVVAFSNEPYSQDLENKNHVETIPLPPHIGPRTFTMIITDSEGDGICCEFDSGGPIELFDNGRLVFTDPFADANKGRFEYGQVSLQLGGLHVCGGALVSTNLVLTAAHCRKSFDTVVVNAYNLSDSSETRLQYKPRRQFIHPAYNRESDTHDAMIVELDGIIEDIDPVVINKYSTVPSVNDTLFVMGWGMTVFGDESSYAEVLQIAALRYINPDACKSMANGNGQSLGDWILEDHLCAWEERKDACSGDSGSPLIVPGNSHKGDVLVGVVSWGVDCAGPLPGVYGRASYIYSWLEQIICTLSSAPPGNMECKAYDVLGTKTTPNTTGCKGCDSIKIQDDDASEKRGTSGIPVGNGISCFSVCALNLTLWFWVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXL5</accession>
    <name>A0AAD2FXL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="275" mass="31352" checksum="AA50EEE34C539493" modified="2024-05-29" version="1">MPNRPQQMQDQSMTRQETREDETLLMEEEQEYQENIHKISSMEAMNDGIDNDNDDNEDPSSIFVPPIHHVSEESRQQHESPVLLSARFDSMLEDYENNEESCREQSSRSIALMYSTLRSPEEERRSSPVSTNFLRSEAELPSNLPPSFPPFLSDAAASNAALSPSLVPSPLNGTGSARRDKPTLLRSLAWSQDSQEERRITKRRKEEPMVMFTTDTSTNDDDDNDDGPSTPEPQQHHRRTNSSSPTMVHWEDEVMELSDFVHKAIQHQQGTPTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYI6</accession>
    <name>A0AAD2FYI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS16457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053238">
        <property type="entry name" value="RING-H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF627">
        <property type="entry name" value="OS06G0192800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042188271" description="RING-type domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="312"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1956911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="367" mass="41381" checksum="1B9587B1F08DFD79" modified="2024-05-29" version="1">MAVQKRICVWFLVVVTLATTMDSTCARNVEESSSSSASSNNNNNNNNNNNNNNTLDIMDGMIESSSPSDTPSVPPSVPPSASPSSNNSNSSSDDDDIGGGLPKYDDNYIIAADDDDHTDDVGKVLGDFIRSGLLVIYWTIGTMCTSYLLCTIYGKRRRRRRQQRELLSRRYEEELPNQYDDDDHIIAHHDNENGDDDLEKTGSRSEQIIKRFYFQTVLSDKSNTTSESIRSLVKENDSRRQNHDEENPSNDNDDKEEKEKAVTTPKKVDCDDETSATTTEESSTSTAGQEKGDWFFQSWWNSTITSPTKKECCICLQGYAPREIICVPITTKCNHVFHKDCVLPWLHRSNACPLCRVDLMKVEEQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZS5</accession>
    <name>A0AAD2FZS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001977">
        <property type="protein sequence ID" value="CAJ1958401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="107" mass="11925" checksum="1A865E736863BE03" modified="2024-05-29" version="1">MLTNFRPFKGGIKGINGSPTNITGIGKLSLPIPGTTDQIEVDAVVVPTSPFNIMPPQLVYKAMKSAGWEPEWPRHNDSEYKIAFTAPSQKEQHEINVKIDNRDLFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZZ5</accession>
    <name>A0AAD2FZZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="319" mass="34985" checksum="859AB5496E21544F" modified="2024-05-29" version="1">MVTKKNKKSTANKKSKAVKTEKVAAAAAAAEKEPVDEPQGDMFTPSQLAGLIMLGVGAMKLYELWNAYDEGTSEDGYWCMAYLNDEVTCSHPSFPSMILAKFYSSVNLWVLTCIMIMVVWNSETYFSKLTTCLCMSPLSTTILGITMSQGDLVSGKYISMMLICFALLCTCVPNSREKIPFLSDKPLSLTSQPSMCLMALFAVSMFDVVRLSGGEFGRENALLETATLLPEKAKILVNFWCLDKLSMALIYLFALYHFPLGIQANFLFLVSGMKLLEGIVQMSMMSEPFQNGGLYQAITVATGIFAAVASMSPTKTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0B5</accession>
    <name>A0AAD2G0B5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0B5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="300" mass="33761" checksum="B44128A02F1752DB" modified="2024-05-29" version="1">MKSSSPGPTRRTDDGDDSPDSPKSRKQSKDFSHNNQNANSPIHKLNAIEEQVDIDASEGMEQSLDTVQSLDDDRIEQAPETDNNRVLFSEKDEAVSSPHKTNSTAHNSGASDDDDGTVVQENQSESDMKKRDLLFLKIVLGILLLLLLVAGIFLVYFFKQPTSTEEKLKELGYPYRKDMKSGWLFDASRDTGSTSYTHYNTDELAREGLGANEVDCASKCASEGAFAGAWNTYYQDCWCFLDVPNSNYCFERCIIEEGIEFSSIRLQSSFEWCPQSFCDVFDAKAYCDFRPKQNVTDCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0B9</accession>
    <name>A0AAD2G0B9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0B9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="10604" checksum="A850313D910AEC54" modified="2024-05-29" version="1">MHIYEDGKEVEEVPIYELTTHADIVKKMEEKGFQLKSSQELLKDRLLKSDLANLEASSLAGKSTLYMVAGTIGIVILFLVVRGKTKARKLRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G440</accession>
    <name>A0AAD2G440_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ApaG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1962086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G440"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="1">
        <location>
            <begin position="304"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="416" mass="46899" checksum="61330547AF37EC0E" modified="2024-05-29" version="1">MASPISKTIAARGSILQHQALKKIPSHRLNPRNFQLSSFSSISIDSNEIMSERVRHDGRQPFTINAMHDKSRVRTIRFYRMLLRQCQSLAATTTPKSSITSSKQDTSERFLLQPRVATSAESLYFRTAPPVATESLDLFRLFYILVERENVLKTGRPIRLPPSHPHAIKRSYSSASYAAPSAQLDTSIDDWFFEVTGGQMPVFQNQNGDVDDEMRNLLVNTCWTSPGQLRSVVRDAFKTDYNRIDTPELHKWTLRAIQILQDQEDLWKRSSVAVTDRIRTVATCQLGRCLGALAKFNTWPSKRFTYKIRIENLTQDHLQLMGRSLSIQGIDEDGKAYEAPVLNSKMLNRPYVPSTVLKPGQCFEFVGNVNLKTEKGTVQGCFHMNKVLANSAVAGMEAIPIGDVIHAEVAPLELTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4Z0</accession>
    <name>A0AAD2G4Z0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002122">
        <property type="protein sequence ID" value="CAJ1962808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4Z0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27884" checksum="26DC80D2FF9AF841" modified="2024-05-29" version="1">MTLDFSVKGKLKICMDDYVKNMLEDFPIKFNKDSKQETPAGNDLLEAGKGKLLSAEYRQIFHTTVARELYVSKRARLDIHPTTTILASRVREPTESDWKKCVRMMQYSFCTLLYHLTLSAESLQVMKWMIDASFAVHPDFKSHTGGTLSFGGGAAQAMSKKQKLNSRSSTEAELIAVDNVVTMILWTKLFMEWHGYPIKKNILYQDNKSAILLEENGHNFFITDQVEKGNVKIEYCPTDCWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G550</accession>
    <name>A0AAD2G550_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS19957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM151 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G550"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026767">
        <property type="entry name" value="Tmem151"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14857">
        <property type="entry name" value="TMEM151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041992125" evidence="8">
        <location>
            <begin position="24"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1962993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="358" mass="40358" checksum="7585F5CF9CDC0631" modified="2024-05-29" version="1">MKSSSIGVTVAILLCGHTNSTVAARESSSSSERRMVTILPKEEPKVHGIFQKHGRSAELFSVPKGSSLLSDSLSDATAATATQLPIQLSSRTRHVSHILASLLTACLFGSILFCWKVDGVAGIGFFICSIVAYFVESAFSSTARYLRNSLTRDGVDEYLDSIKAAIPRVIWDIQCFHYRRRRVKYSSGSSKRVRTETEKIVTHRASGEYSFDRWKDETDTRSLSRMLTGGGNTDTKDDDSTQAQRSSMPKQFTKITLDKLLLFANDEMYHDFMDQESRFRQLHQHRDLHHSFSSRLEVDGYLPKILVVNHSLGGAGTGLIKNQWYWIFTCFGLTVPYRIWFSQHCSNTEVTITKEVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G596</accession>
    <name>A0AAD2G596_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G596"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041975392" evidence="1">
        <location>
            <begin position="30"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="358" mass="39780" checksum="0BCE15FC9D11B587" modified="2024-05-29" version="1">MVHLKRSCSPSLAFLVVMSTVMLSSFAAAFQLQQHQQIQQQQPSTRRIPASVPYDRICLKAEMGGTDVEDNVGEEDDFTAVKVESTNNPAKQALFDSFQDPTSTSYYRLHTPTKERTALVTEMTNTNPTASPGSTKSFRHLAPGIWRVVYAPHIATFGMVVSQFLSALFSQSPLFNTVAADDVTNKKGTTNKNSPGVSIGFDPVYYLMRPDGTMTSHARLVVKFLNNKPAESVTWFSVAGTYSSQDEDQICRVDFDEAWIQTSSEKMNDDPLELPPYASLDEVPASLGKDIINALGRFFFVDGVSVFPVSYLDDDCIVFDFELLGTRICAKKVHQLLNDEDDENNDPVLQFLAEKEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5M1</accession>
    <name>A0AAD2G5M1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome endopeptidase complex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5M1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041936486" description="Proteasome endopeptidase complex" evidence="4">
        <location>
            <begin position="21"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1963494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23391" checksum="FEE7B38ED6D0E945" modified="2024-05-29" version="1">MHTKKIVSIFLVAFTTLAAANFEPYELNGGLISAVAGDGYSVMATDTRMIGPGGYLLSSRNYLSSRIWSVDDTSIELMSGIESSFRSGDSDVGVVMDNNKQTTAPGIITMTMKHGDTLFGSTMIGAAGCAADCEALKRAIRADIKKSTQQGQLSSSPTADQVASCLSHTLYSRRGFPFYSFCCVAGMGGVFVFDAIGSYEQVAVASAGTGRESLQPILDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6G8</accession>
    <name>A0AAD2G6G8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6G8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="171"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="265" mass="29785" checksum="ACE59D47BD505C2A" modified="2024-05-29" version="1">MSTKQVTDDEALRALLSSAAERDEERKIERKGNERKRWESRNDDRQQGRGSNKRSRYDDRSGRGGNQQNNNSNENSDYYGPASEQGRRDDDGSSGKNNKDNEKPPPTHKPNFGLSGALAKDEGGGGNVYKGVVLKFREPPEARAPNTQWRFYLFKGKDLVDTLHISKQSAYLMGRNTEIADIPMAHPSLSSQHAVLQYRALPTKDGSRLSCQPYIMDLESTNGTFLNGVRIDSARYYQLKKGDVLKFGASTREYVLMTENTTLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6P1</accession>
    <name>A0AAD2G6P1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MORN repeat-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6P1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="85305" checksum="07E2ABE460E83D12" modified="2024-05-29" version="1">MAESSSQANMENPPANSQNASQAASNSTPLPKCFCNWKHCRTYQKAFREYKHPFFNGVIKLKFTQNDSRSMGLKSTVDRVLHVDSARRNDWKDGENGEPFCRYYVARHHFTEALINEYFQDRRGWDWNKPLSMREAKKLLWSLDRDDVYLSDDEESNEEDDRYVQAPNVPKDKVREMLKEFKDQHKKALAAESTPNEQETVDTARSTLSNSVADTLKVFEDSVGQEDPDTKDVILAEKEEENRRLRDEIQECQQQLNSLRDMVKKLVDMDRSRSSEPTKKKKSKSKSKSRRRQESSSEDEDEDSSSEEEWSQERERNQQSDDDDETISTLHVNGEVGGQQARVPVTKPRRPAQPVRKTSIHSRRSVRRTSVHSRRESIHSRKSLRRESYHSRRSMRGGASDDASVVSRQSLASVSPSIKSLPREIELNDEEEEDSFFDDSYRKPDDDARSVGSRSAASKASRRSFVSGQRSRGRNSRRPTTASTGSSRKKGAPGPPNANASTSDSRSKGSDGGSGNGRNVPREIDLSGDELEDVTYSNVSNDTSFVKDRQIVDPYGEKGVYTGELSKSTCMPNGRGRLEYEKEGRWYEGDWIHGRWTGTGCLSNGDGDFYEGGLKNDHKHGEGIMKFADGRIFEGEYIRGQMIQGQMTYQDGSVYGGSWVDGMRHGKGKCVFVDGSEYDGEFREGNFHGHGKMTWNDGGWYVGEWCDGEMHGRGKEIRPDGSLRHDGEWARGQPIRSAADSRRRRQQMPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G815</accession>
    <name>A0AAD2G815_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G815"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="86" mass="9586" checksum="C634B060DFFA0FC3" modified="2024-05-29" version="1">MMFVLLLQPFLGEAFQLSPSSSIQHPPTTVGLFSATVGTRKADATVTTTDEEPQMSAAPWDGQFEELLAFKEEYGQLQHLRRNTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8D6</accession>
    <name>A0AAD2G8D6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8D6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="96" mass="10385" checksum="5F79BF8C2E06E8F3" modified="2024-05-29" version="1">MSDQASRSRNQEPFLLPTHSAVINFHLEESNKAVQESESMAKNGKMKSKAAEDTKKTKSDAEAKGAKGKKSAADKKSKPAEDKKKKPAGGKKGKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8G6</accession>
    <name>A0AAD2G8G6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylosome subunit pICln</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS21840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8G6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1966257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27294" checksum="F45FDDD547DB593B" modified="2024-05-29" version="1">MTEEGNMFMVNEDQFPHVILREEAADLSALKTIDSQQAFLEQRGDPVFVASPIACRLEWQRSSSEEKPAGETEVNKEDVTGNVFISSSQILFACEDASNDVAIGATCILMHAMTEEPELSIYLQLQEDGCETLEATFTPLDSNMCQDFFNALCKLVSLHPCDGDDDEGDEMFGQEDMIWAPASRGFGTDAFEDEERGATDDERQAMLDRLDSILVVQPEYEIQEGQFDDPILDGQFEDAEESGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9E1</accession>
    <name>A0AAD2G9E1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002278">
        <property type="protein sequence ID" value="CAJ1966335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9E1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="21717" checksum="231F0069FA7F22E4" modified="2024-05-29" version="1">MKTTFVAKKSVKKRVESDLQQPKDRDPIDSKMVSETQTEEKRVDDNEAQRMADKIEAQRIAEREARRSGHYNSIVPNLSEWWMQNLYSGDAVDEALERHDRIHTGNALFMAWEERFPGAWNQPCLWYDNPFNDITGTATCEDRFARIFTSMNSDNSQLTIIITETLIVNMLLCGHSIAGEIFGCKGQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAZ4</accession>
    <name>A0AAD2GAZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002346">
        <property type="protein sequence ID" value="CAJ1967739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1192" mass="134399" checksum="D1DFEF9BBE4BDC54" modified="2024-05-29" version="1">MSRIQQATEVKTPVATRLATGELVPDNTGVEEARLFEVVGLERSSYHHMPSVKVRQESNGLEQILMMVHSDRVCDELVLVMDHIYEECARILLPSDAKWLQDQHYLKLSKSRGLPVDQKKRVKILEGFAKGLFVLVKKMPRHTMAHQIARAIIVDNATDAELANIFSHLSPPTFCKIARKRGHEDMTGAIESGKEPEKKRRSVARIDTETLTRMVKHILSFSQALSWGTKELRQKGKTATITFPRLTRTHPVKGMFMDYARKEAELQGIELDKNQQSPQRTTYYLLVKHLTSKAEKSITCIDYVQDILVNVRVTGLVVIIEQVIAPTQHKTMKRYVLILQNFLKYQYDGHLQKGSAICSHSIHYGLGLEPQSNTGNTESTSVQIQGVEHCPACKFVEYFMRIVLPDAVKANRSSANSRSIDDALDYIEDSLDCFHRYQAHHVRVVNQQKAIQEVDLKLKDEVLRSKQRGTTAKITMDFKQKFVEKRLRSSQMNDFGQRGNSWHIGVIEYYDYEAPCQANSSKARAVPMMFPIDQILDTGNKQDGPCVLSMLEAMMKMVNVQFGFVKRIVLASDNANCYHSKDLIFPICFINQLSSSPRIVKYIHPETQDGKGSCDSHAAVAGTHVDRHYICTRKDDTLTKNEACTPTELANALCTNGGIKNSSVQLIALDFPRLDKISQLCSGAGEAAKEYFARANEIRFFPELDELADWSRLDLKNESTWSAAQPLIQVINYSGISDGMVFRAGFSGWQNGKGTFTPVVAPSDDPEWHVRMEASIMGLNAIQRAKEYIDISEVGQSVIARLNAHVQAAKVGKAVIMSQVVSEIITGKNKTNNNEDVQHGAGLLENLMDDDDDDVSESDCFESFYGEIEHTTAYVDECQQDDTAFFSDVEDGDIGCSAGVDEEAANSKAMAGDANGTITATSQLLDKAPREHYEKTTFFTRVEVIRYKPFRTFQPTKQRATKDQKTKKSVEEDEEAGKGHESRRVEDRAIGLALHYINSPECSITPALNDNMKEYKVANHWRPRETLMRDQGWARRPLSGGLYGRNYMNDEFKKIGIAQFNRGLVNKGDKQSPTQTLALMKEEHQGFYCYPGLHEIVRMFSGLVQQSKQNGNKIISFQKKSGPLVSPEIKAELQSILDKKPDYTPAPLVDAWKKAFAANREYDEEKVRKQATRLRAKLMIDMKKRLKRSMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBI5</accession>
    <name>A0AAD2GBI5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS23452</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CAKOGP040002413">
        <property type="protein sequence ID" value="CAJ1968902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000002">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041973158" description="CTP synthase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="CTP synthase N-terminal" evidence="12">
        <location>
            <begin position="70"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="412"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1968902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="654" mass="72372" checksum="4048E5D8547F9F8C" modified="2024-05-29" version="1">MIQISLLLVLGVIIPGLLAISATQGIHLTTTPKYSADPIVENAFHQLRGGSTQSSTIEEMAQELIDSNRKLVVVTGGVLSGIGKGVTASSIGVLFRAMGYRVTALKIDPYLNVDAGTMSPFEHGEVFVLDDGGETDLDLGNYERFLSVCLTKNSNLSTGKIYQQVIEKERVGDYLGKTVQVVPHVSDAIQQWVLEVAKAPITHFSKATAMATDTSRQDNDSMEPEICIVELGGTLGDIESMPFVEALRQLQEQVGYKNMCFVHVSLVPVLGSPISEQKTKPTQHSVKMMMQLGLRPDFLCCRGKEMLGDDTRKKLALFTSVPEQAIISLHDVSNIYRVPLMMVEQNLCGMLAQRLRLPKYRKHGLKYNAAPDLCELRNSKLFREWTQLANSVDQPENDCTIAMVGKYCDQGDAYLSVVKALTHASIATKQKLTIEFIDSSELEGGNEETMARLLKCDGMVVPGGFGSRGFEGKINAIRKAREEKIPFLGICLGMQAAVIEYARSFGGMPTAHSAEFQKDLVEGEDDVVIFMPEGDRERMGGTMRLGARETILRDGSLARKLYGHERIMERHRHRYEVNPIYARKLEGLGLKFVGKNTDASGERMEVIELDNDVHPYFVGAQFHPEFTSRPEKPNPMFLGLLEVVKKQKGFDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCH3</accession>
    <name>A0AAD2GCH3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002392">
        <property type="protein sequence ID" value="CAJ1968624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCH3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="138" mass="15175" checksum="DC386C9593237943" modified="2024-05-29" version="1">MGIGTAPLQPHHDSQPSLLDAWMAVSARVTEYVGWTPEEIEIDGDKSLLAAALLEDRLCVISDGSYKLGLGAAAVQLLPRKGGTERIIVRCQTPGLPDDQSAHRSESIGLLAGIMVVDWLLDQWTNKNRFELYQKQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD56</accession>
    <name>A0AAD2GD56_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002458">
        <property type="protein sequence ID" value="CAJ1970086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD56"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="159" mass="16886" checksum="086A3F8D615B7DCD" modified="2024-05-29" version="1">MGFLSIGAGTTTTVPKSPIDDGASRQGASLHSSKSKSDSDENPKNTVAHEISSRQGALLNSNESEVDSNENVQLDEWNNSGPTSPPVSRAESPTCQQFTPERVSMTAVASLEEDSRKPAVTASARNQTNAPSFLLGIDDAINAMMTEMNRAEVEEESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDG0</accession>
    <name>A0AAD2GDG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF27">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="210"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="432" mass="48835" checksum="059B57ED5B07BBCF" modified="2024-05-29" version="1">MQLHRTKGRPHGCERYLTFKALFPASVLLLMFAVSFTAFDGGISVSDAGQISPDASNPKASVENITAYTPIPKPSVENICPQALHLLKDDSSKLASIHEELKSFHDGGGNVKVIEEYLNSYMDKTIDRLDMKYYPKGQSEPLEAAGVTKHIIETQKEVDTAKRGGYDQFRLPGYFKTVKGKRLKDFKIDVMEPFTPQRWRIGLGPIAKTACKSVDRIRSGEGKNYDDKFMCSYTDLTKNQNKPTMQQEEPSSECSMISIGSNGQWGFEEKVVASTNCITHTFDCTVQDPKKPNVDAINFYPYCVANENKESEGRQFRTYKGMVEAAKLTRPPDLFKMDVEGFEFDVMTQMLEEAHKSGTMDLLPTQISVELHYATRMYDIPWKMRTITAAEIALFMGMMYRRGGYVPVHYEKVGPACVFCAELLFVRMFCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHH1</accession>
    <name>A0AAD2JHH1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001780">
        <property type="protein sequence ID" value="CAJ1951104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="135" mass="15219" checksum="95CEF9B95861F78A" modified="2024-05-29" version="1">MESEDNEAAVTKQGKRRKNSGKKTSAVTPIESTLDESEDKVSIVGRNVDSEPANPDGNDMSNSDSEDDNDKEEVTDYYDKMKLAKLWAVNKEHFGKQPQKLRMHDIVQVLRKDDLDNEKENHTANNIASRPTTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI67</accession>
    <name>A0AAD2JI67_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001789">
        <property type="protein sequence ID" value="CAJ1951595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI67"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1235" mass="139577" checksum="0064E50E5561172A" modified="2024-05-29" version="1">MPSPTENNNSVVTPNKNACRPDASPNDAVIPVNDTTTAPLPPTNNKFTDREVSTIARIVWNEDPATAAMATELQGIFTVMQLSKLSDFEGQDATELIGFAGIPRPGGTIGPIQSKRLKDFFDYATAPSASLPPDLTYTKIRTVLEARAKELEVAVLGSMTGDGTSVAPTGSDFKFKAPVCDLFTGEPEEFWGWWDSVLLEFGQSGISEALTDPEYHNKSDSAAKASSAGWYAIAKSLQCGHANWMSGEVSRHTNRKVAHDFYTKLMKTFNTEENQAHFMVHAIDSLNEIKLDHTKQVHEFINDWKQIINRLNENKNQLATNREILRVFLLRALQSDAFEESRQFILRNPLKTIDDYLDHIRNRADSMRMLSGDPPIRDYGDIVPGIIRRAESRTKTKGSEPPKWHIPFFPNGWKQALGRGAFRRLEEWRRAAHGTNKRPRDLEREFDMKKVRNKSYDPNLDRKTKKARRGAIDTEEDDNSQDGTTDSRSHKFRIRVLRRTTSPPEPNEPVLITDSGADQFFAGYIWRRLSTTGRLVELMGALAGRHSGTVLPVASVVGKLIDAAGNEWCAVANEVLHDTSPNQHESLLPPAQVRNAGNAVDDCPSDAKTTCGDFGTQCCVFGSGKAKHTLPLFFDGLKCYYRMEAITDDELTSLPRIVLTGDAEYEPTSRTTIRRMNTDEIDWKRTMAFPPDDVLKHTLEATTQLIPVVEAESPQQNLAELRGGRLKHVVQHILLLTGAPAEYWCYCLEYVAFVKARTSKRVLNNRTSWEAEFGAVPDISKCRFSFWQPVWFYTPHGAFPRQRMMKARFLGFSPDSGDAFTYVIVTEPDDEKAHRQFFTRSVIRPRYPREDAPFVFKQGKSLEIFKRDERTILTAVSDSDFPPALSDRAHNPLPTIQEEPQPLDSVEEYERGIEEVYGPPASKRLRTDPTSDEVLLRTDQEELQPLSAQDPLRTPSVPTAEVELPTELHPQDQEMLVANSTATVDATPEGPRLPQTGPVPVTQEEPTNSFMTEQGESASISPDGDEDSVHSADEALDDHQVSPESLDVHLRNLAGLTEDEDLFDSICGHEFRDGVLFLQILWKTDETSWEKYRACREDFPYDVAKYICSKKIGSASGNHSNGPHQRWARTFLKKTRRVMRRFVRYHGYSKPMLNIHDFRCPREDNSDQIQLTKMHKKSQPRQVRRAKKKGRLRRPLPIRFGIPIPRTVNEALALDDDNGNHFWREAMEKEIASLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIF3</accession>
    <name>A0AAD2JIF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="552" mass="58578" checksum="29402960E7A9F583" modified="2024-05-29" version="1">MELVVQVSFRRKKKDESKKESAKSSSAAPASDKAPSSKGTSSKPPTLDDIPELIETMLNSKGEKSAAATKRIYELCDVGHKQNRVPMVCSGKYDVLTPLARCLTQESGDGRHLACLALNNLSIPTENKRVMALGPASKEVIGGLCKVIAEDKQESYLCCICLMNLSFLEASITSILQHSPSPSGKEKAPLDNPASLIRVLEKLLSNSPAAPKTSSGKSEGVRWACGLIKNLAKSEDNASIIGKTDIPKCVIENIRASTAPPSRWTSNSLEDFSLFVILNLAQWPGSREALMKAGAVDVVKPIMAEGDLQGLKATMACAFLDASWSSFPDGGNPAAKSVSELMTNIVEKKGKDGQYAYGVFKLYTATKAYADLAKSASKADGAEGDANTKVLAVPSAVALNFQIISDLVLSAMDDAEGGSKYVPDAMSAEHAVTAIEAMLPAILQAGEPPRKSVQSEKACGEISQMLLTYADISGTSPQAKTSARAAAEKIKESASSARPILEISHDLWTQYRKREGQPLDQFVSNDKGVEVDESGPLDFLPCASSDGGCIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIP6</accession>
    <name>A0AAD2JIP6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS14339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="12"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1953736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="361" mass="39313" checksum="11B22CB0BD9A267B" modified="2024-05-29" version="1">MKSLMNDVSFVWLMLWMANNIGVTLLNKASFATVDFHYPYFLSFIHMVCNSIGSLVIFRSIEHDARTGTTGFFQSLLGTINRKKLDDKGRKYILGFSVIFSLNIAVGNVSLRYVSVNFNQVMRSLVPAITIAMGLCLGKEISNKRIIAVVPVVIGVAMATFGDNVFTALGFVYTVLCILLASLKVVASGEMLTGSLKLHPVDLLGHMAPLAMVQCIFLSFVTGEIGEIATREDLFESFYPAAVVLTSGVFSFSLNISSLMANKLTSPLTLCIAANVKQVMMIAISTIIFATPISPLNGAGIVVVLLGSGRYSYVSVLEKTAAQRKDEEPLDKKADDVERATEEEHVQLMASEPDTSAVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKU9</accession>
    <name>A0AAD2JKU9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="265" mass="30121" checksum="4FC70BEDBC3E6DF5" modified="2024-05-29" version="1">MISIPPPIEPPTRQSMNRQSSLFGSMRKLLSEEFEIQKSVLTEDLMVWRAGCSKKELEFRDQIRSFEDDLASPDYINKLNTTIETRMSSCQESTEYYQSNPDLKEYTLEKELDRIPYTLITTDGKRQLTKSDDIRNYVATEETEEEKESHSILYRAANQSIFADVIVALTCSDGLVRPQLHAGTFVDKCSLTIDLSKKDPHVRATCFVNVSIPDAEGHRLSMASVLVSIFYCPSKEQLRSGIMHLLPHKRLTDEEVAGAARSLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLK6</accession>
    <name>A0AAD2JLK6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RCK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS19418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the castor/pollux (TC 1.A.1.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044849">
        <property type="entry name" value="CASTOR/POLLUX/SYM8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010420">
        <property type="entry name" value="CASTOR/POLLUX/SYM8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31563">
        <property type="entry name" value="ION CHANNEL POLLUX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31563:SF10">
        <property type="entry name" value="ION CHANNEL POLLUX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06241">
        <property type="entry name" value="Castor_Poll_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="9">
        <location>
            <begin position="159"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1961877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="697" mass="77821" checksum="518C9270EFEBD682" modified="2024-05-29" version="1">MFSESDAWSYLILAGGFLPILKFLWDEYSLAKSKQRFADKVHFTWSEQVEYRLDYHLSSSQLAKPGLLMGFTFLLIVFGSLLLTIVDDVPVSVSAWLAWTYVADPGTHADAEGLGHRLVSFVITIGGMLVFALLIGIISEVIGEKVDHLKEGKARVLEADHTLILGWSDKALAIVQEIAYANESEGGGIIVILAEEPKEELEEILATAVEAREHGLKLLGSKVIFRSGNPRTEKALHQVSASTARSIIALSQDDLDPDEADSRMIRQVLALKALQELQCHVVVEMQDVDNQNLVSLIAPNISEVVVAHDVIGRLMIQCSRSPGLANVIEELIGFQGSEFYFDEWPELVGKSFFELTCRFDDAIPAGVKTSKGNIIVNPKSDYILKKGDKLLCLAEDNDSYEVNDGSFPIHESKKFSGTPSPTQKEKMLFCGWRRDMADMIKQLDEYVQEGSELWLFNAVPTKERRELFLDKGNKEELTTDNLTIKHVVGNPIVRRDLLRLQAADENGSTGEVAFLDGFDSLLILADVQNGTDMQSSDSRSLSSVLIIQDVQKQLHEKHKKEGKSTRPLCSPISEILDTRTRSLLSVANCTSYVMSNQIISSLIAQVAEERDLNFVLSHLLCAEGSEIYLRKATCYMDFKKDDRESFWNIAVRARCMGQVALGFKRKEDGFKVILNPPDKADKQIWSREDQIIVMALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMR9</accession>
    <name>A0AAD2JMR9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="695" mass="75496" checksum="248E8454A8F9E71D" modified="2024-05-29" version="1">MSEVGSQSETGSQSLASHGDSSQDTVPITNSAGAGAGAGGQTTATAPGQQVRPLGVNNRLPSKRALGKSVRGQSVRHLASSGGTATNASNNSNQPPPQQADAAAGTLTQPENPKDKEIAVVLHKLRRTKKEDGDRQSDLLSRLRILLQERVDDMDDKRPLSNDAAGLGAAIVEIMRHLPPGEEVAIMEECTCILFFVSEVDPAYKKGIARLFKAMGEHVDNVAIQKASCAGIYNIIVANPDSIPRIAPSLPGLLKTMDAHPSNSSVLCSVLQVLGEIARCSETKPFFVSSGALQHVFQAMKKHMSNSKLQSTAYLTLVALSKDSSSKTKRHMAPSIALVMQGLQTHPQEKDVQLHGIQTLGNLLPPANLTEPVVNTFCQSLSAWKESEEINEAACLALCHIVLHCPFDILVGMSVSEEGFISYVVDAMGRFEDHLGVQYQGLRVLVHLSSRVADNMGKHVEDFRQVHERLLSERGLDSILKAMHKFGKSHSLVAQIGCELLVNVTRNSQDFQRAIWAKGGIELLLVCMRTHVKNLRVQDLGCCAVRNICLNKDNRKPVEEQGGISTLLVTLDFFVTNSTIQAYGLDALGRLAMDEGCRQAIMEQRGIEAALSGIKHHRTHAGVQDRACFMLLNMTQSPNVTQRMLEMELLPIVQECKVPPKKAAMDRWNVLIQRLESAKPAGIGAWFGRGKQNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNJ8</accession>
    <name>A0AAD2JNJ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="558" mass="62183" checksum="838031569F6C5D12" modified="2024-05-29" version="1">MVFLTASKRITSLIGSPLLRLGLAARNSKLFSPLVGGEGSSSSSSSSSSSLQSISLQQKQLDTPYLDMALLIPFAQKLLSLALYDESQKRVSQHYSSTGKDGSILKSLYQGQQKQSSPSDGDASVATATKELSNLRVQSYDHVIRKSLLPKETHSNLQSWMGHLRILKWARAEFLISKYGPMVKEAMDAYPQLRGSPQFQRNPNQNFFLQLARGRLVLPFSQSTSSSSSSPSQEDEADHANKTSNSMMLLPTTDTVVKAFDMKDWAIQKDSQGLHESTNVILDKLSSSSQIIDQQQATTTTTTTNNSDDTAASMEDISTEELLHCLSGGHVQYCGPLNAICEEANLYQLWTKEYVQHLGDYLLQEYSSNTDKTTIVDIGAGDGLLIRYLQEYMGGKLRKGNRRKHKNAITGAALPRMVSTDDGSWGIFAKAKVEKLNVEEALEKYGKLSQDEHLVVLCSWMPQQVDWTAQFRESKVDEYILIGEADDGSCGHGWDTWGNYTFAPSESDIPPFQQDGYQRWDMDSLIPFQFSRFDSAISRSSKTVSFRRKRSSTKKQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNY4</accession>
    <name>A0AAD2JNY4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002377">
        <property type="protein sequence ID" value="CAJ1968293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNY4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="883" mass="99705" checksum="614C817F65DBD3C6" modified="2024-05-29" version="1">MSNRSHNVITLDRKAKRSKADPDAIMIESEVKASSSSTSNEDTDMANSEHGNEEEKESTAYEMLVKDSVQQQWSEDYDGTLKKYLTIIGKAKEFPDAQAVNFRHDAICEAVVAAFQGNQDMISAANSAMKTTSALAITSLNFLKHQQERLKIENEMPLYGFLHTVCMEVLKEDYKRKSEAQKQSANKNIENQRVNLFHDDLRKHEDPNNVVFKFCKHLNGQIAQWGGGDTYFAGYTVLFQSSGMGKTHLIFSSLKSKIFGVYLCFRRSTDGRTYPPRSPVMNWLIQSEVEDGNTTSLFQSSALAAGTLPSAKTTRHMLRFLAVMRATQELFESWFDEWKKEKENPPTPEDWFNHQKGGEETDFLVFQTKLKNRANVVWEERRFENQAGSKDGFEDNFIFFMDEGRTLLEENIFRDVRRCFCKGYFSTRHLDSSARATSVNQGYLLPPFYFVNCLDLFIDSNNNNELSKYGRPLWHAYEMFLQKNKNRLTMANLLQFARFKLLRSEKLLAKLDGDHKKAAAIACLACRAALRIHPGRRFASELVGGHMAVCSHVYNDREAILINYPSEPILAEGSRSALLGPEADFSGWKTSLEQLQLAIQEADVDTGKIGELIHRIVLLLAMDMAKMEMAGRSKHKGVSAYDFLKVLVGDSIDASGNGGTQIENLKTKYVWFNHFLPLYYVPDASAFEQIARRRAATVCKPGQNGIDHEIPLMDATYSNVVGTLAIQTKNVVSKHDSDYPASAGWKLGREFAFHGSDRDGSSDSASDFYYFALYHNIGYQRSHGTESFECEQIEPSTHAHVWTCGHGQRDCYSPIGLKMVGLDLPLFQSTNEKLCSNVKQMQKSLKQMRDQGRSPIAHFTDEMKTSIGQLTPLAYATVAAPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPD5</accession>
    <name>A0AAD2JPD5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS23832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1969672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="179" mass="18391" checksum="FB4E5427B292B193" modified="2024-05-29" version="1">MGDSITEGTIVEWTAQVGQMVKEGDVVALIETDKVTVDIKAEIDGVLTQCFGELEETVEVGANLYELDTEAEATAVASEGSAEPAAAEPAPAPPAKAAPASDAPVAAKKAPSSTRVPSIQFLGKDGWAQKLSGADAAVVYLPKNYGRPVFSEAEMEALATGGANIAPQVKDYSHGALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU10</accession>
    <name>A0AAD2PU10_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU10"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="133" mass="14745" checksum="A4D750198306F830" modified="2024-05-29" version="1">MTPPFTESSPQASPALSSFLRSNFRDKEITSIVDDRIRSPSCVRLRRREAHQAEALTRSVKSCNAIDSSATSKWVTALAKDSTRNAGFNDEGLQHASRFASITAEQSLYRPSRRASITGILNLPILKESHQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUD1</accession>
    <name>A0AAD2PUD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)</fullName>
            <ecNumber evidence="3">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS12199</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000003">
        <property type="entry name" value="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042261198" description="phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)" evidence="9">
        <location>
            <begin position="21"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1949642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="728" mass="83553" checksum="B6C9C0E4268E1B95" modified="2024-05-29" version="1">MTRTIPLMQLLLVSFALARGFPVLPRSTSSPPPSTVAFLSQIKDGDSNTESNLSTLSRCLVEEYEGYSNSLSQGQEKNRVLAELEPQESIWRRMFREISIKRKTRPGSLVLLRCCESTFNLNETFTGWLDPPLSDEGVKQSQHAGRLLLSEGFDVDVVYTSRLKRSITTAWHALETMDSLFIPVYKTYRLNQRMYGALEGLPREETVSKFGIDVVKAWRQSMKAQPPKLSRDDPSHPIHDRRYSDVPPEMIPDSESLIECHRRAAPLWEHQIKGDIKNGKTVLVVAHKDTLRGLLKTIDNIDDKDISDIKMPRGVPMVYRFDEQMEPVEPSDMSRKLLHTNGQFLQKPGKTLEILGHESGPISIQNNCQMQRRELTLQDSMNSLRYGATSETEERVGLVSGEDSGRAERWSDDPCEFEEYDVFAEEIEGDGEEIVPTILSSNKLLSNQTLEGPFIVLIRHGRTPHNQMELFTGWEDPPLAEEGVEDARNAGRLLKRHGFEFDVVYTSWLTRAIQTAYYTLEELDQLWLPMVKSWRLNERFYGDLTGKSKKMIANKYGEEQLKKWRRGYTIRPPPVSSYSLNYPGNDERRAKHFKDLRFSFRESMARSLEMKRLSFHRKFPKTESLKDCMDRSIPFYTKRIKGEAIRKGKRVLITSHENALRGILMHLCEIPEEAMNQLHLPNGLPLVYDVKRKCLYLLDNGSGKNPAESHDFGPAAKYLFSPCETKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUJ5</accession>
    <name>A0AAD2PUJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042263776" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="130" mass="15056" checksum="DA5898748E36AB49" modified="2024-05-29" version="1">MKPFLLLLSLLFLIGTVHGNTRYETDELTGHVESSREEILSTRKLRKQQFADLLAGYETQLEDHNSGETLLTEKQYNKVLHKIKAYKHKLQELDLDADPRFVDRIVAREAHLNEVTRARILRRSSGADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV50</accession>
    <name>A0AAD2PV50_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="882"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1050" mass="110272" checksum="5B68EC4C3C773FD1" modified="2024-05-29" version="1">MFASSEEDSEENEVLERAQEQLKALSADKVQTNQKALQTKQKAAANQLTSEEQIGVVAAGIGGAVLGLLLGGFADLNIPDIDLITSPIVPPIVGSVALSIFGIAGGASTGSTGKFIRVAFGGPVRLIVNFITTTFKNYVERKTNEIKAIPSNVVNAAKAKVAETKQGIVNIPSKIQTAAIEKVEEVKGEIKATPGRVAEATQKAIDDAIDDTLDAVDNAIDVVKAIPTKAVKGVENSVSSTVKSIEGSVSVIVPEVTSEAPPAPKVAPKPPAKKPEPPKKAPPLKGLSDTKLEVPKLDVPKLEVPKLEVPKLEVPKIEVPKVDIPKIEIPKPDPAEQKRKQEEAAKKKLEAEKAKEAAARAKAQREEELRRHKIEQEQARQAALTEKQRGAEDKKREQEAKKAAMEQQKKKAEAARQEAAAEKQRIAEIKEAQAAADAEERKRIAEEKEAEAAAKKAQAAAAAEEKKRLAEEKKAQATAAAEERKRIAGEKKAQAAAAAEERKKLAEQKRLAAQAQATKTQEKARSQPPRPTVSLGDLFGGFVAKSEETLSPLAAPVKEQLVKPAAPVKKSPATAAPNGVPVLSAWRQLSSGAITGRISGSANFREGETITTSPVAMGAKGGSVVKTSSGSSYFLEGTVATSKPTGGFRIPSFGGSPQSGTRPVSSSGNDRKAALAAAAEAKRRAAEERKAAVAAAAEEKRRLAAEKKQQAEERKAQAAAAAAEKMRIAEEKKAQAAAAAEEKKRLAEEKKAQAASAAEKKKRIAEEKKAAAMKKTQATTAQKKAAAPKVERPPKGVPIIRGWKSRRDGGISGRIYGSPNFEDGDFVETTTISGGKIENGGTVTTATGSRYFLSAEPPTKVASRFAAVLGSSPTITLTNQRKAIEDKSEADAPPKATFSLFDLFGGGDSGGKPKQAPPATSAPKAKSAPVKKAPTLSLPKIQVAKPKPVEAPAKETPPPPKKAPAKKTTPPPPKKAPATKKTPQPKKGAPRGVPALSGWKANADGSVSGSISGSPNFRDGEKVTTSPIIKGKYASGEVVTTGSGSRYYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVE0</accession>
    <name>A0AAD2PVE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-dehydroquinate synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS15395</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVE0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08197">
        <property type="entry name" value="DOIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF1">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="10">
        <location>
            <begin position="109"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="11">
        <location>
            <begin position="220"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1954803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="55741" checksum="F0BDCD4CAAD22B1D" modified="2024-05-29" version="1">MKTQTLNLTQPKVTPGSIDEDNVYRNRFARPGKPLESNIIIESGALNKLKTRGREYVPELCHEAKNYLLVDEIVDSVYGDKVLQGFRDAGLEVYKIVTPADAVDESGNPSAERHKTLAVFSNCVNEILDSGISKHSCIISLGGGVTNNLAGYIASSLYRGVTLVHFCTSMMSMTDAAIDFKQAVNHQLGKNLLGSYYPAANIVIDPEVLETLSKRHILNGISEALKHALCQSRKVTEAIVNPLDEDLHQALRNSDFLEMVCRDCIDHKVPTLTHYNESDFNEMVPQYGHAIAHAVEHLSFHSKGVSPLLHGEAVAIGMCVTAEVSRILGVCDESTVDEHYSYVSRAGLPVYVPDGIGIEAIQNKLCYDKHYVKKPTMGLLAEIGKMHCNRDGSFSVEVDNEVINQALVNHMKRRDNADRCTDLYTIEASDTLKSGHPSSAGFTVSSDGSDSNPASDRSHSRSASLDSESNRSYGPATTFDWDPMTAKSFGTRQQGISNCYCNPWECSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW25</accession>
    <name>A0AAD2PW25_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW25"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042217089" evidence="2">
        <location>
            <begin position="21"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="334" mass="37459" checksum="331C2CA424A2C41B" modified="2024-05-29" version="1">MFRSLILVAAFASSLLYSEAFLTHHRVERRSLSPLQHAGHDHNHDHGTHDHNHDHSIHDHNHDHDESDDPPPPPLDEEEIREIENAERRKKVKFRQLVADSVAVSNPEHLPKLLANNIGAIAALQGQEGAAIIKEIVEDAKAEGEEQFNRTVIVIESILSFAESFVEEAESLDSKNKKLLGKIINAMKSSEDAMDELMEVERDNFTAGFLRHIEGECERIGNAPKMTTESTRLIELLRVIQARVLEEIGADMGEATLVLGQLMGYDDRDELLGVLDAGLTVQGREFAVEMKGLTEEALRGFESVHGGVEPELLDRVSFVDQRLTNYLEETNEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWC7</accession>
    <name>A0AAD2PWC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS18141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWC7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1959722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="471" mass="51957" checksum="1FA0DA66B1BAA391" modified="2024-05-29" version="1">MPGGKLQNQRYRVAFILCLANALCYACRMNIGIALPHFVPDNGDRGIVLSAFFYGYICTQVPAGYFAKRVGVKQVLATGVLVWTFCDFFTILTYPSLFLLSLVRAGMGCGEGVTMTSLHIFASYWFPANERATLVAMVTSGSDLGNILALLISPWLIQMTDGRWQVIYIVFSILSMVWLVFFMRHVTSNPQEHSLVSKLELDLIQLGSAGLPIIEETYSSSSSQGKIKKATMPWRILLTSRHLWVIYASHFAANYSWYILLCWLPTYLTEALGWNLSEHPGLTVAPYVCGYLGLLLSGRLSDFLITERKIPTLYVRKMMHSIGSFLPAAFLYVLPYTPPSASITAIGLLSGCLFFGRACTSGFWINMIDVGGPDHAGSIMSISNSIGTLPGILGNVVTGYLLQQQQQQGTSGKESSWIPVFHLASAVSAIGGVIFLFGATDRNVFDTVQLRKHKDDDEGVEFDRDPLLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWR0</accession>
    <name>A0AAD2PWR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS19659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF79">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041964352" description="Methyltransferase type 11 domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1962382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27027" checksum="2727EF60C21DAC4D" modified="2024-05-29" version="1">MIIQLILVCSLFYSWLSQTASAWTINRYLFSGRRITSLSSAAFDFSSPAEWDKFYQTEEETNQEHVEWHSSIPLETIASYVTPDSKCLIPGCGNSRLPDVLLASVPGIRISLQDSSTICMSQMEKKYGSSIEGYYCGDATKLQDQFPSMEEKFDTILDKGLSDALFCNEAWDYWISSLLRGACKILKEETGIYLLISYKLPKSTQEFLQELGAEIGLEWTFDVLEYSNNRVGLSMAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXB8</accession>
    <name>A0AAD2PXB8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS21480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXB8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004825">
        <property type="entry name" value="PRK06181.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1965891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="287" mass="30251" checksum="7D11E5956392C147" modified="2024-05-29" version="1">MPHCNEKTKACFAGKSILLTGASGGLGSSLAKHLASCQVDTLILSGRKKEALDKVAKECQSLSATTSIHIITCDLADKESVRKLGEEALALCGTVDMLINNGGVSSRSDFLDTQLEVDERVMQINFFSGAALAKALVPNMVENRSGKVIWISSVQGLLGIPSRTSYAASKFAVQGYCEGLRAEMASSGVTIHVASPGYIRTGLSLAALTGDGKPHGQMDDTTASGADPNEVAATTLDSVAKGKADFVLAASFSSQVAIWLRLLFPSLLQKLLVKRFDKAKAVKEKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAB0</accession>
    <name>A0AAD2CAB0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS278</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1899461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000029">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1899461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1042" mass="114535" checksum="A3E9CA1B66DBA61F" modified="2024-05-29" version="1">MTSQEKQSLDEKATSIKDLAKLINEPQSLPLNLEHLKAAGGVTGLLKLLGTNADSGVEEETVEERRALFGCNTLPSTPRKSFWQLFVDTFDDATLQILIVAAIVSLIIGIYDNPSTGYVEGCAILAACLIVSVVTALNDYQKETQFRELSAVNDEVDVKVFRAGKFTTIPVGDIVVGDIVSLDAGDDIPCDGVVVAYDGFEVDESALTGEPEEISKDAENDPFVLSGCTTVAGTARFVAIAVGKNSQWGIIKSHLEKEQDETPLQEKLDDMAAMIGNVGIGAAAATFVAMMCIKIFINPEYLHDVTVFHHALEAFIIGVTIVVVAVPEGLPLAVTISLAFSTKKMLADQNLIRVLAACETMGNATNICSDKTGTLTENRMTVVEGIFANTKDINCVNPLAISVNAIEIILECIACCSTARVLPPAPAHSINSDEVVDSRPKLIGNKTEAAMLLLAKSSWGNNDDVDQRRESANFGKDGGSRLFPFSSKRKRMTVLVNKNNSWTLYHKGAAEIVMENCTTYMDVDGSEKQMTEEKREFFKRVIAEYASKALRCVALCHRKKIETVVKTDFSKISLAETEEKLEKKMCLNSLVGIADPLREDVIGAVATCQRAGIFVRMVTGDNIETARAIAKQAGILTEDGLSMTGDEFRKLTPAQLDEILPRLQVLARSSPEDKHILVQRLNGGLMPATKEEWDEVHPGRDYETERDLLLPGYKQEWDESRDGVGEVVGVTGDGTNDGPALKAADVGLSMGLSGTDVAKKASDIIIMDDRFSSIVKAVLWGRSVFDNIRKFLQFQLTVNVVALTITFLSALIGYNPPLNAVMMLWVNLIMDTMGALALGTEPPQLELLERHPYRRNASLISRPMWRNILVQATYQLSLLVYLLNKGPELYDCEDGSTRHFTILFNAFVFCQVFNEFNAREIGDIFDPFHALDKSPMFLFVIGFTCYAQWLIVEYGGDFTQTAPLSMSEWQWTVGYGALSIPMGYFMRLIPVSEDPDSFAGLPEKGEVKKDNSHLRATFFAFLPIIAALVYQLSYEVEELREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCB7</accession>
    <name>A0AAD2CCB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000016">
        <property type="protein sequence ID" value="CAJ1927479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1927479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="66427" checksum="77E79D741CDE3502" modified="2024-05-29" version="1">MSEPLYTMFTGPGADNNQQLLLEGKLPIPGGLAYPTQAFLRHCRLHDSYRPRPFPLTVEEHVDFWSRTPENKGSEPHDLHNGHFKAGALSELLASCDTAFRDLPLHSGHVPELWKNLMNFAIEKKPGDFRPQGMRTIQLFNSEAQANYKKAGRAAMKNAEEDDIIPKGQCGSRKQHQSIDLALSKRLIWDSLILERRSSGWISNDAKSCFDRIVHWVAKTALRRFGLPVTVTNLMFDILAKAKHRVRTGFGDSDRTFGPTGDVPFQGCGQGNGAGPCIWVAISAILIDAMEAEGFGYKSRTALTNEEFFASCFCFVDDTDVMESNDNVETTGEDLLPSAQSALDLWSGGISATGGAINPAKKAEMPGELTLQEPTGLWATLQRLQPDEAERTLGVMMAPLETGTAQHLALREKAKNWAAKFRPQHLLCYDVLPLIKATALKTLEYVMPLSTLGRSDWASIMSPILQASLHKAGVCCSFPRVVVFAPLKYQGLGIPHPFALQVFHHLSVLMRHSANRTKTGQYLEANLQSHQLETGTSFPLLQQEPTNTGILASETWLKRVWIKLDSLGIRVEISSPPLSLHRANDRLLMDIFIDAVDPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDP3</accession>
    <name>A0AAD2CDP3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS2014</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDP3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041947684" description="Fatty acid desaturase domain-containing protein" evidence="12">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="13">
        <location>
            <begin position="118"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1930641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="479" mass="54274" checksum="B8D19776305FACA5" modified="2024-05-29" version="1">MMMFRSATILLAMSSSALAFNIGGKRQSPLSTPTVASPKKAVAVPMDTPNFGVPNLSKTKLDPKDDWVRNLDYDGFAKEVSALGKELRKNTGKDDVDHLNKIVNWRNMAAVFGLATIWLPVNPLTVAALSTWTYASWTMIAHHTCHGGYNRVDAGRFNSRGFALGALNRVVDWLDWMQPEAWNIEHNRLHHYRLNESKDPDLVQRNLDFIRDGKYPQFLKYVVVAFFLPIWKWFYYAPNTYKELKTNEWIRSGKELPEGYDPELAVTVVSMLDPGRKATRKIVNPLDFYKNVVGPMFFARYVAIPGALALIPGVGPTLAVRALTSLVLAELLTNVHAFVTIVTNHAGEDMYTFDDAVRPNSGSFYVRQIIGSVNYDTGDDVTDFWHGWLNYQIEHHVWPDLSMLQYQRGAPKLKAICEKYGVPYVQENVFERTRKTIDVMVGRTSMRRFPTQFEPADHKIADSSLTWKSTNGAIEDESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFR2</accession>
    <name>A0AAD2CFR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000280">
        <property type="protein sequence ID" value="CAJ1933555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1933555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="821" mass="89846" checksum="7FB339B100EB4271" modified="2024-05-29" version="1">MEKDSNESELSGHRVKERKSYSSDLDEEASDGNSQQEVSEGDHQDREEEKEVNAVVDKAENNETQSTEITSNEAVHDADRESEVVAEDILLATANSSSRRSSRIMLDGSETIDAINESEMEIDDAAEEKIMAPESTIVDDAPKIAQESMVISFGAAAAGEEVRELRAYTQRPKCEQQNKVSEKVSPKADLKESIDSIGTVQLLKPGLLSTAMAKNEEENDRDGVPTVALSPTMNAKKRIDGNGDEEVGWRSDEYDLGMDDDSSSPPQKPGAFQIGTQQNGSLALSEEPDDSKQSPSNSPSSKLANSGRSTSAAVIDEESLQREFDNKLKADMMVSAEYDEADNKQGFWQKNASEICCVSVVVIAGLVIGLFVGLGQASSRNVGNITKAPTTSPTLLDDDQYLQVLFSSISGDEVFRNPSSPQSKAFKMISRESHDDIFDVREIGDQYLAERYALRVLYYSTGGDAWLINDHNFNSTLNTCSWMNVTQGNRLLCNDLGEVTDLFLNAVGLNGTIPSELGVLSSLSELSLAKNSLYGTIPSSLGEMKDMKFMQLALNSISGSIPSSFERFAKLERFIMHVNRLSGSLPNLWGDEFRRLRINRNKINGTIPEMPKQMALDWFQVSDNAFTGTLPLNLATQSRLITLAISNNRFEGTIPNEYSALTLMENFVVDGNMLYGTLPSMLGRMTAVDWFWVHGNNFSGSLPASFETMTNATQMKYHNNNFNGTLPDEWSALESLVSLEVFNNPYLEGTVPSSYIGLEALKSFALAGTRISGGLSDTLCNTQELDSLSAECGGATPFIECPCCTTCCDGDFCALQNLNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG79</accession>
    <name>A0AAD2CG79_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000169">
        <property type="protein sequence ID" value="CAJ1931640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG79"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="226" mass="25884" checksum="8F8B4F4912265558" modified="2024-05-29" version="1">MSQRLNNTAAHQIESGDYDKAIKTLNNALRLSRADFRQSQTSHLFMLEACLSYSQNLSTQQAAAVGEGDENSSNNSNSSNKNGLVIYQQALRVPSEYMSHPMGRILPLLVMYNMALANQLKSLKETNDDKQRRVLLNRALKLYELAYQWQSKEEHKSLRLNMILVNNIGDIHRRVNNKTKFQRCMQQLMRTLLYVRVTDGENIQQIQPMETTFRRNIQMSSSAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGK1</accession>
    <name>A0AAD2CGK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS2436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000158">
        <property type="protein sequence ID" value="CAJ1931544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF2">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="40"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1931544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="251" mass="26913" checksum="00C2D4C0645F9273" modified="2024-05-29" version="1">MSTQSPPTSASQRSSSVESFKVMDVLKRANELQAQGHKVWHLEVGQPESGAPALVASAAQAALAGEQTMGYTDAFGLLALRQKIADFYLTKYGANNIKIENIVITTGSSGAFLLAFTGCFDAGDTVAIASSGYPCYRNILQALGCNLASVEINSEFKLTAKELKQAIDTRKEKGQPPLKGLILSSPSNPTGAMLSPEELKDLCQLCDEEGIHFLSDEIYHGISYGMPEATAITYSSNAFVINSFSKYYSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHS2</accession>
    <name>A0AAD2CHS2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000419">
        <property type="protein sequence ID" value="CAJ1934930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHS2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="666" mass="75618" checksum="6C5BE4E897BB440B" modified="2024-05-29" version="1">MFLQVATVSDITTADGRYIRQCIWNGFRDDTYWTPYNWPRTVRPGRPYWELWQRTLSRALLPSHGQHHPLLQPLGHWHDNFESWNWFWSPTVGLFHREGAAWTHLALVGSSTTSWRYAPSGSHSGTASLRRPRSWWTCPLPSDVLCATVRPLSGSDWVLLTGTGLPTLPSSAFTPSILNAWQASADLCTDYYGWVPDEIEVHGDEAALADALIQGRLRIISDGSYKNDLGSAAVQLLPKGGTARIVIRCQTPGLPQDQSAYRSELIGLLAGIMAVDWLLQQWFPALSQRPGVKIACDGLSAIEMAFEDRPLSPTDAQFDLISSIREAISRSPVSWSPRHVYGHLDKSNLFDELTWWEKKNLEVDGMAVDFRKELEAAHQLIPPNPRFFTELAALFVADTKQSRLSDHFIQECVTLPRLRQQWRNRNVISEESENLIDWETLGRAMRSLPAGLQRWITKHWVGMCGTGKFKVYWGLASSAACPRCGEFEDHLHVPRCPAAPARDEWDRRVTALSLWMDAILLLLQGVRDSSRPPCLVSRTIRPAFLAQEAIGCQGLLEGRLASLWLSLQQNYFDKIHSCQSVSLWASRLSQQLISIGFYMWEQQNAVRHSDDNVQLRERHCVVNEGIHSQFDMGSADLPPDIRRMLTCRHSVLRKSLVDKEEWLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CII9</accession>
    <name>A0AAD2CII9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000097">
        <property type="protein sequence ID" value="CAJ1929846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CII9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="185" mass="20762" checksum="7C1534C110269868" modified="2024-05-29" version="1">MRTRRDKNSIEFCRWVEVKNGSSEPNSKKMFARRKFEVGDAITFLCKDEEHCGFPVLGGFHARIVSMLAESNTYLTSNGTLRCSKPILKGEEITRFDGNSERDEILESVDMIVVRFDTMKVGRVGCVNRSHPGILVCYPNGSKELECNNHLQCFSSTRLFPSAVLGKTGICVGLQLQQLGYKTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJQ3</accession>
    <name>A0AAD2CJQ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="153"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1936195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="343" mass="38407" checksum="22CD4E24A1429916" modified="2024-05-29" version="1">MVTTRSKKRPYDSTEEGKETNQRESKDTSDDVSKRRTTNRSKQAQAKQQDTTAKETDTKTPKSMNPSDVSSFVDKILKEAGIEETKTQNGWCLKEAMTHILKADSGRMFPLVQQHGAPTIFASLQHCKISTGGAAEAMTEPKTCFESLCRIVAGQQLAGAAAMKMWKRLLDLADNGKLTPEKVLELVKNGMEEGLREPVGLSNAKARSIVNIAQAFHNGDLSEEFLKTSEEQKIRKELIKIKGIGPWSCDMFCMFFLELPDIMPIGDLGVRVGMKRYFNLKGSDKHGYLCQKKDLEKMGNATGPFAPYRSVVAYYMWKVADTKDVYQSNSNSKKQSPKNNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJS7</accession>
    <name>A0AAD2CJS7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000413">
        <property type="protein sequence ID" value="CAJ1934898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJS7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="817" mass="92130" checksum="8FE88F1D6006FD4F" modified="2024-05-29" version="1">MRPPTDRELSNPDIPHVVLTSDGDWDPSALDHSIEDMEELAKSVPDYNSEDEERPFDLVGVLKNNKALTSFKEPKLDGTIDYFQNFNCVLPTDGLYEQRHRASEDLTWFDCNMADLFGFDASLEDSPIPECFEVYEACKRPSVLFDPGQPVNYDIESATLEANSFKDLILDSDKPTLKRNPRHKAWTTPHGESDRCPPPRVHFDDTLTVHESSSQTIATIKNSTLEGTVAFLTDFVLEDDLLQQLPETSMGRDDATSALSPVHGGNKSDRESDQTIDEIATDESILVCTLGILEATLDCTLDSLGPLDFDLINRGLSTANIPYAMRIPKHCADHHQNVLDSTAIATGEAKPAFNQVDSDSLGPLDFDLINRGLSTANIPNVMLIPKHCTDHHQNVLDSTAIATGEAKPTFNQVDSHNCNRALPFTTMNGHPALDCAIDFFQSFVYANPIDGLHEVHHPPTSELARLERSMEDPINLDRTSATQVAPPELEIYQSHKQPSTQEAHFELVLYQSHKQSSAQEARFDDDTRKPDGRNGPPPCNSFEHGLQPTEVELKNPRSAVKSHERNWERLRSYFAWLPKQVIQKNLEHYLEDSTQLATITTIDITILVPSNFVSTSNWTYIDDWRTLSIGRKQFEQRLLAKDEMVKFIHLATCLSTNAFHMKQSTTSTEDQMDSDRIVAQIHGEQTTGLQPLLEGNEPLLDGLPWHITKQYKTTLYQLHIWHTLLPLHHMNKVFHLQRFSLPHIDGPKATETVANSSPRPNTKADNQHVVLSLHRVREAIASNMLPFLYTEDAKHQANILSKQYQQSGHSYMHYFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJU4</accession>
    <name>A0AAD2CJU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS4346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000437">
        <property type="protein sequence ID" value="CAJ1935009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="426"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1935009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60876" checksum="BDFE33ED2A633D33" modified="2024-05-29" version="1">MNNNGEEFVAASNQGETRGHPSCISVHAGDVPTLTSTGGDGSQSRPTKKRRRNEISAAEKFDSQRRRHWIALDDKVQQTGLINSKVALLYNEIARLFLEEARLDEAMELFEKRLEIEKKLFSRKDHPNVASTYHNIGSVLRSQGKYEEAMELFQKARAIYKQVDGPMHTSTAAAATGHEIGTVLEYQGKYDEAFQQFQIVRDVYLKEFGLEHSSTAATYHSIGHVLCNQGKYDEAKVQYKEAIKMKLKVHGPEHPSTASSYHCFGNVLSDQGKHEEAMKQYEKVLAIKLKTLGPNHPSTADTYHCIANVLCNQHTYVEAMEKYQQALAIFLKVHGPVHSSTAASYHCFAVVLCKMGNYTDALQKYERALEIKMKVYGPEHPSTASTIHCIANVLSEQGKNEEAMGHYEKVLAIKLKTLGPVHASTASTYHCIANILYYQHKYGEAMKHYQKALEIKLKALGRNHSSTVATSDCIRELSRTSRIYNGTIMNKKIHDSGITKYSRKSPVVVSTEIQPTSLSASHPIPTVPTSSPLPPLVQEQKASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKJ8</accession>
    <name>A0AAD2CKJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000624">
        <property type="protein sequence ID" value="CAJ1937257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="262" mass="28568" checksum="740F8AFDC4F05871" modified="2024-05-29" version="1">MKSAVPALLAQALVSFLPRIFSLVHLFSLRNIFRLDADGSATFSIQGSELDTKKSQLGFYGRQKETKAIQKCLDDLVNTGNNKLIYISGISGTGKTALAVTVADSVVKDSGIFATGKFDQKLCDEPYAGIGAAGRHICGKILHRKNYSEHMDFEDIRKMIINNVGPELPTLAMILPEIKDVVGSSDLLLAQEDIAGGDYGANKERVNHAIRTFFRSAATFFKPLVMVLDDIQWADLTSINLIQVLMTDESSSNHANTLGTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLB0</accession>
    <name>A0AAD2CLB0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000535">
        <property type="protein sequence ID" value="CAJ1936013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="170" mass="18804" checksum="17049C2CB1ED8E44" modified="2024-05-29" version="1">MTPLPLSTALVQGCTLSTTPPEAVSLVSKRTIRSSPPSIELPTCYPGTTTATTTTTTNNTNGPSSRIRITSFENNEAAAEDDDSSNSSSVHRNSRLLLLQEEEEQQQQGSLSLLFSSFANDDLTPSILLNTTHHHQSSGSRTSRRYRRQRNRALSDEDFCSIIDDIYFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLF9</accession>
    <name>A0AAD2CLF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS6045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Bilcke G."/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
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        <source>
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        <source>
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    </evidence>
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    <sequence length="5572" mass="540845" checksum="C46BE77243DC3D7F" modified="2024-05-29" version="1">[encoded data, 5572 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN85</accession>
    <name>A0AAD2CN85_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protochlorophyllide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS4512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
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        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="29"/>
            <end position="51"/>
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    </evidence>
    <evidence type="ECO:0008006" key="7">
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    <sequence length="450" mass="50590" checksum="FD1938075DABA8A6" modified="2024-05-29" version="1">MNFDQLRASTIASFLTQLLFEEAYSPSRVLLLGPSITMVYALSIWFTYALSHEFGWISSIPQVLFPPLAIQLAAVAAAWKTVVDNNQVDPDMIYRYNVFFWILSIHQLYHLRQSLVVGIPTSKIPYYGGKHLKGQTILVTGANAGIGKETVYQLSCMGARRIVLLCRSEKKGKQAEWDIRMKLSTQPPYEHGNDTELIVCQCDLSDFVSIRTAVHHIKTNKKIETVDVIINNAGLVMGTHSKSKDGYELMMQANYLGHFLLTQLLIQEKLLNPEISDGDDPSSRPPRVINLTSSTFKLVGKEGFDFDDMFCEKGRKYTMFGQYSQTKLANVLYTKELSRRYPKLLAYAVHPGIVRTNVTSNMSWYLRVPNAIFSWYIAAMQKTPTQGAYSSVYCAAAFVDNLPPSGSLVHNCHHHADDAATTPASESIPDAKRLWEVSEHLTGLNFKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPY4</accession>
    <name>A0AAD2CPY4_9STRA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942468.1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1942468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="232" mass="26092" checksum="98DBDF03D58382E7" modified="2024-05-29" version="1">MATPKMVPEFLVGLWHRDYIKRANKNKEDGIFGPPQTNVQVWYLQTPFAFIDVRREPGTTKDAMAFAGVTTVELTDPPLVKWHACLDLDPLSDSAERWEQADKATPKLTEDEGFFTRLKENLYRETDPAKTLEEQWAKQHDGNKRLLAVRRDTSLFVVVGDHFGYAAQGGSNGNDQASPQFLAGHVEDWKVAISPSHLELEGSSFSLPGKQDDWHLLPGSTLELGSLDILFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ35</accession>
    <name>A0AAD2CQ35_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
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        <location>
            <begin position="207"/>
            <end position="230"/>
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    </feature>
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        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="354" mass="39963" checksum="82D5728F12C05A07" modified="2024-05-29" version="1">MKSPPILNRANQDPELQAAEARAAGESIIRDHLDNHLVHNSGASSEYISWIATLHPENAQIEIDERFFIPGNPWWSIYEQTVNMPCATAVAVPAADGEREAHPPNAHQYNATSDGEAKYVLSTTTHASDDLTEQSTPADRQEEPEQKLPHYCLRSSPVDMCIALITTFHATFFTLVFEFSASIFYFVAASFYHIAQVFSPSNMFTGFFYSIFMIMYFAFAAADSALLLGSVLGTEAAIFVGWILGVLFGGIWVANKRHQFVRRVCHRIRWAFRHKHLEPPRTFCKQSQVGTELVDQCQNTARANAELDTEFEIDDSLEAQEHVEPAYAQHREESPPRTQTQPKEDFEQKSAKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR03</accession>
    <name>A0AAD2CR03_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000325">
        <property type="protein sequence ID" value="CAJ1934054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR03"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="109" mass="12396" checksum="E6C6052AE61BC4AD" modified="2024-05-29" version="1">MAAVPPFFTVHDDMVICGIDDVTLFQGRTQAERIAYKIFSDDFTTTMDSTIDKLNEEFKTLAGLTIAQGQIRLMPAIKKNIRAFIQWCRDETLPQHHFLSLMQPNCSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRZ6</accession>
    <name>A0AAD2CRZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001035">
        <property type="protein sequence ID" value="CAJ1941551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF31">
        <property type="entry name" value="OS01G0873500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1941551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="733" mass="83148" checksum="D7DF1524D052F894" modified="2024-05-29" version="1">MSEYKERTPRFQFSGEPEDYDTFGLKYVARASIKRFDGVITGDVTLRTKPEMDAETDAAKIKEDEEIKEMNIKAFSDLLISMNTDTAEGKVAFNLVAGSRDKVNYPKGNAKEAWDKLKDEYEPKTITSYIKMKSKLNKCHLEKFANPASWITELSKICVRLEEMKHPVSEEDQFIHIIGSLPLKYRQEQKDFEKMMKANTLTIKYIKEELNSAHEDFANATEGDDDDEDKEDKDVALVTGQFKGTCNNCGKYGHKKLNCPELTPATRQGGNRNTNNGNRNRHNGGERGPFLGTCFHCGIRGHKKHECRRNPENRNSGNNNNGSTNNDDVAEVMLMATESFIAPDEPTKKKNVWFEWNEECEESEESDDEDEDTADEVIVHTIVEDANDKVPEHGNFLHDDFFDNFMANFGQNDCDAKNDETFRATKPTSEYAFVTEEIEITRYSDVDGSGTYDSDGDEIPQLVERKMNAKHYASDEWDHDNGMPGYDTDSDDSDDDDIPPFLVNRHGVVHGHDEVPLIDGHDNISDDDSTYDAIPQLIARRQYDSDDDDSDDDNDDSPHNEDEPYFYDDDGDDESTVQTETSLQDEITSTLNGIAMANMDKWKSEEMKLTPHTWFGDSAASTHMCNDDTNLYDYDVIREEIKVGSGKTIVATNIGKLKLRVKQTNGKVVMMVLTQVKFVPELWCNLFSLTAAMDKGFDLGNQGRIITVTHGPTTIGFDMVRLWDRVLDSHFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS33</accession>
    <name>A0AAD2CS33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="78"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="375" mass="42494" checksum="7EA359F58F6A25DD" modified="2024-05-29" version="1">MSLCSKSCSNSMRSSKLKTATFVSVAIGIYYLLSLSGHRSIIEGQLGILSTSEGDSNGDGFNREYLLAPEVQYTPKIAWLMSFPNSGTSFTMSLVGRASNRSFATNYADEVTPRDISSASLNIYHHRHDGPFWPGMSGKILSPRPLPESFVITKTHCGSRCMYCGPEVYVVTADDFLSSCSSGHARIANKTEAVDVHYPPERVASAIHLIRDPFTNIISRFHQRRKNQEDKNLTEWLSQHPNNSTGFQRWCKELDNQYRQEDIEYFGLEHVPKAPCHGEFFKYAQWHSLVEDALDLISHPVPVLTVYYEDYASKLEETTETILNFLDLDLVGRIKVFKAKTEVSEYFTAEQKDSIKEFIRDVASSAAWAHIQHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSK7</accession>
    <name>A0AAD2CSK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS4295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000424">
        <property type="protein sequence ID" value="CAJ1934958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042290382" description="Sulfatase N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="30"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1934958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="627" mass="70915" checksum="045DFAA977DD9B12" modified="2024-05-29" version="1">MASCVAPSLKQRHVIIILIFTITIHNVIASTSENPKKLPNFVVVLTDDLDLTLGGADASTLKKTRNLIADQGITLTNWFAQTPVCCPSRAELLTGRMLHNIRKPSMDAIGCMSVDVQEDLNIPFYQEYYFARHFSEDLNYTVGIFGKHLNTKNPKGCPRGVDRWLINGGGDYLNPSFYWASKGVEPTTVHFDNCTDTTGMPCYSTSVIGNATIDWIREHYHKTRRRRGGDDNDDNDCTQQQQQQHEQQQQEQPFFALVSVKAPHLQDGDGFPKAIPAPWYENCTIPETIAPRTPNYNHSCPDHHWLVRNQPPLTQLQGKEVDELYQSRLKTLLSVDDLVEGLVQTLQDLDLLENTYLLFTSDNGFRLGQFRMPEAKFHPYENDIRLPMMMRGPNLPSATRTGTTTTTTSQKNSILGTHVDLMPTLLGLATQTWNNSIVPPTMDGSNLAGALVVDHSTSIRSNNNNNKTNNASFGVEESSPSMQANPSSAILVEYPSLGNVVRYQHLMDTYNHTFLALRIIVDNDDDDDDDRRWNIKYIEFFDCREDWNLTGPALEAEYYDLDQDPFEMQNLIPTISLPFRRRLHEAMMMLYKCKGDSCRRALGRGALEHVMNDNNNNNNDKVSTSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSS8</accession>
    <name>A0AAD2CSS8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001079">
        <property type="protein sequence ID" value="CAJ1941784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="193" mass="21595" checksum="46D458526604CE76" modified="2024-05-29" version="1">MLEIAVELDDLDGTPLDLQWLEPDKLAKTLGILMPPAQTGKHNLWLCKGKQKHGRTRSNLASFTTMMSFLSYAPQSRRLWSTQWRSPSSLNRSGNRCYPQCLVRHFPRPVSAATFLVLWSTPLQLKKHLDMLLCHPANKSKTGAFLKAVLQAHQLEPVPPMVSSNKSMAIPPSPSTWRLVLPPSNKCAKGTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTN7</accession>
    <name>A0AAD2CTN7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTN7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="158" mass="17686" checksum="1CA56DDFAC949FA1" modified="2024-05-29" version="1">MTTVTGIPPHIEVACQLKDLRKDMLDLIKATGKNKKDRKAAEKEFREQVTNAVRGSIEQENVNNGNVSGSCMISILDNHKTQTKNELKKMLTDFKTTYLAMTQGQPQAPPIPPIQGATTTNCSLSSDTKMFQYINKWWFVPEIFQFQKPPNLSLLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTU8</accession>
    <name>A0AAD2CTU8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">60S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS5082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTU8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000002">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1936219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16810" checksum="879283325C1BD483" modified="2024-05-29" version="1">MFAKKFRQHGPIHLSQYLMSVKVGDYVDIFADPSIHKGMPHKGYHGRTGIVFNVTKSAVGVRVNKLVNGRIIEKRIHIRIEHVRKSKCQKEILQRKKDNEAAKAEAAKTGVKINLKRQPKQPKEGYFLKAAGEDGVLTTIQPLPFSDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTY3</accession>
    <name>A0AAD2CTY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTY3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="471" mass="51925" checksum="47F824B780766EA5" modified="2024-05-29" version="1">MAESFNSTPSEQVVRQVATIIGVDDAIVDNVCKRMEEEFILQEWQMSALDASEWKALEAPIGLAAAIRKLASVEDRNDAWRTNKSGSAPSVIASRSPYAQRLTDATKGSFANRSGHKDPKSAEMFIKTIHEEKEKQGGSDDDDASQIDAESGRTKPPPTKPHSLFKLLYKNHHEACKAFHSTTFPLSDTFDRALLHSKSGADLKAHTVFKMEISVVVAALLLGAAIELWGIFPQDAVAQKHEIPDGGEPYVPYIMALIFHTLSGLTILTQLMTVFLNVGQLYVATAISENKFPKFFQQILATTAWTNGLFQLGVVAFMVNIGILVMGTILATTSDKYTIIVCGLIIPLLVVIPCEMLFHVLLTYVGRTAFNGFLLVSHDNPNSDDILSFDPTSASVAEGTLCQNYFLDVNTNDEEVLDRIQRLRQQHTRSTSTRGVESTTIRNSRLIVPLANKHNIGPDYFPKFQGVKKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTZ2</accession>
    <name>A0AAD2CTZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001013">
        <property type="protein sequence ID" value="CAJ1941451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="607"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="917"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="921"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1941451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1129" mass="123995" checksum="F33734D3BB1109E6" modified="2024-05-29" version="1">MAPNKAGANTPASYMPNVPVDPEHEKRIKAEARAYALSGISSTAKRKSPSTIQTSEPGPIRKVARQSNVSISSISSTVNPQRTDAMLNYRDDLKPKAQVPVVGPPRVTTFEGDEDYVLFVKSLNLDDAMFAAADNDDEEFQLSDVDDDDEDDDENDLSEMYNTDLPSTTEVATSTPTLSSPLSSSPVQLPDFEASMYHDLEEELGSLLEEDLEAAVQSLMTSKTTNPSNAITPSSPSCKSPEVTIKPQCTRALPDTRTDSPATPLRDAARQGPRAQVTYQQTQQLRHLLAQHYQLLVQQAILGIRAAHFQKLDKEKSDFLSGETADDLAEILDGAVGMLQDLDQNRKDAIRNSIQLGDTVSKSDDSTISLPGRRSLLSKFAETSNSSHQNQKDRPLTRLAFSQSLQQGSNWPKRTTFDILGLVKLKETFATIDRSVAGIKKPGSILELPTHGEACRMVLRQAGANIEEMLVPGERKITDNFCDCGEFFGELFKEPCKDEQDLFLRRNRNLFTSGEDNLVLRGVNLYGEKQWILIADRYLPDRSVNIISQRYSKLCVMLYKAHGITIDEKGCLDEPPKLESVDDIDEAKVNELELKTVDPPAILNVHRWSLEEDLTLLKAVPLMGHMWAELGARLIPHRDRGHLRKRYQVLERRVKATVARNSKWEAVSSKPSKGQGLTRKLFTPAAALRPPPTKTGGKLSNAVAATKISVQLKVPRMSIEKAAASLAFLRPPKADSVSVSALKSTPSVQSAEVVNYDSGAPLSALHCLKPPADTSRNGITAGRMKLAPVAQASTSKQPSAKLSTHSSKLSFIDTNFGSELSSSRLAFEQLVDGTGEEWSQLSRVKKMLENDPASQPDDVIENSLTKSPMRSNLSKLPQMELDSDSMSGLSILQSEASRQHDTEPPTVARASIMSRVLESSSKNEEHSRLNSKEIVSKSVANKADPNKNTPKKQARQKPNPATPLPSTPKRPNFFSMTGTPIGLSPGFRPSPNGALNSIKNKSLRASGLLSPPPSSVSRLVNDQSVDEFRYCDFNISEESQQRFEGASRDQRANVPSTPSKSTAFGEHLMANDLDAISALSALSNSPFKKGLERRDMKRKEVKQSFFATVVGGTKKTERQGSYPKHKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUX5</accession>
    <name>A0AAD2CUX5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001571">
        <property type="protein sequence ID" value="CAJ1946083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUX5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="142" mass="16050" checksum="4F8A370F52D40D4A" modified="2024-05-29" version="1" fragment="single">MPFKAIPKKLTVALMARVAKVSNYYPAKGGLSAYYSPHMIMHQRMVDASNEFVAEIGAYVHRYGHDTENNMAVPTIEGVYMGPTADIQEGHRIYDLNTMCEARRAKIKVLPMTDQVIKIIEEDARLEGVTELRTYSKRNGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV50</accession>
    <name>A0AAD2CV50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS8091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="869"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="1003"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="1217"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1942726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1302" mass="144929" checksum="A1B3C56DD57FF07E" modified="2024-05-29" version="1">MSTAEKKRRGRRRGGGLRKHQEIENVKVEESFTLHHGPTGKSGEGCYVSATTSNNKRYYGVMVDQSALKEASSLWFQDQADSLELNRRMKLILDKEKEEEAKQAEEGDDSQPNKRQKVEEKTELPPSAKNQSVQKFKYVRSTSSSLSDYRQLLATFLNVNEASEGDSAKRERILNACESGGDFVGPDYYQYEVPPATLTSQIEKAESNEGWRASMSLSTFLNDTQLPPFYPLSNLQSGNNRVLGMLNMKRDNSGNVVWDKNSTTNAEAEAALLAGGTRLQSVPMQTRSGEYYKIGVIGGGIAGLSCCLELLTLLKNEGIKAKVTLLEARSRVGGRLFTEKFVSPKDGSTVPMELGASWIHGIDHNPLAAMCRRANIDFVTASEEVVMIDEKAKTVDEKMDERMGQLFDDLLDHAAEDCWTPSDAGSQQKAVKWYASVFAKPKDEKSESEKVPQPTGVPLHRKSTDQTVDYEIGKAISKHKLREFSKLGSAEHRMLLWNTKNVEYALGSNLADLSMKFWDSDERHAFEGDHVMLKQGYGAAVDYMLETLQAQSEYFELVKDYPVGKVEYARKSATHQYGGDSFGTSRKLVEMSDTCSVSKQDGTDTKYFDFLICAAPLGVLKEATQYPSLDGSATTLSFQPALPFSKIDAITNVGFGLLNKVYLCFDSAFWRSKGLFESRDQCLFGNVTGKHPHHYMFFDVGKIIGDKGDDSPAMLMSLISGKEAVKCEHLSDEDLVSEVMESLQIMFSNQTLPKPKFHRITRWGKDKFSRGSYTFLPPGATDQDFQSLQSPINGNGDSLWVEGNETMRVFFAGEHTTALHPSMAHGAMLSGQRAAAEVISTILFKSDSEKEIDRLIPEPLFRYKNPLAELKCSLCHKDGGTIREGRLVAFKRGSRQVLVHNNCAENCPEVEVVDSKWKHVIKAVNRGKALNCDICKKNGATVGCTGENCFRIFHFACAEDTGWRFDRDSKVFYCDLHRPPPESTDQCDRISLEFYLRKNSSSPVVCAFCQKGNSAVSSSDLLAFQCGTRRICAHENCIKLTTIIDTSEAEHSRMGKEYRNVFRAFDMAKTCTCCERGGATITCSEVSCASIYHYGCAIESGCSFQNKKPFLCKLHRNRNLKPAFKEVQPAEEQDVDPNNFRHDLFKPITSASGQERVSLPSNEGMGFTVPVINSSENTIEISDDSSDASESSTEEELDPQVVMNARLSCEATDPRHMVRLKRPLSDSKWDMSLRVDGKDQSHYLVVASVSDTGYSNGLKVGDKIVSIDGKKIGTCDIRCFEDVLVQLQKELSLEVEVARPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2024-10-02" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVP3</accession>
    <name>A0AAD2CVP3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000669">
        <property type="protein sequence ID" value="CAJ1938140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="216" mass="24795" checksum="C68A2BC5C18560BC" modified="2024-05-29" version="1">MPEAKEGEDRIYMKITGMMVQILIDMAPEYREXXXXXXXXXXXXXXXXXXXXXXXITILASRVREPTESDWKKCVRMMRYLFCTLLYHLTLSAESLRVMKWMINASFAVHPDFKSHTGGTLSFGGGAAQVMSKKQKLNSRNSTQVELIAVDNVVTMILWMKLFMEWQGYPIEKNILYQDNKSAILLEENGRKSAGKRSLTINICYFFITDQVEKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CY46</accession>
    <name>A0AAD2CY46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CY46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31675" checksum="1089326E3AD06C6D" modified="2024-05-29" version="1">MASEDEEGGGGYEWLSSCCNEEQNAFLFLYLIYYVAVLLIGETIFAKPMRLLATAIHELSHAIACWLTCGQVLNLEVYETEAGITRYVGGWRCFIASAGYLGEAFFGGWFVVLSGGRKTATAAAIGLMWALLLSLCYKPNRVLVFVTVFYIILTIAVVAVEWFYFTPCLTYLTLGYGVFLGTFAELDIFNHLILHSIPSSDSYSIYEESGQSVCCMPRCVGISWLIVAIGFQLFSLYVALILMSEECEHQGWMQCLLHSDLELRFDKFEVWPDDWQWKIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYJ5</accession>
    <name>A0AAD2CYJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001523">
        <property type="protein sequence ID" value="CAJ1945802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="82" mass="8881" checksum="2F9F0E1C2FD533E1" modified="2024-05-29" version="1" fragment="single">MVAELGQYVHAIGTDSNNSMEPQSIEAIYIEPTKGQCTGHGVLNLNTKKMISRPKVVVLPVTDQVIQRVEAWAAAEGVTSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYP3</accession>
    <name>A0AAD2CYP3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYP3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="13856" checksum="9663782ABB0EB3CB" modified="2024-05-29" version="1">MTSSSSVNQDALAKFQKINDWNNSYSLEDELSHSDSLHDSTASSFDLSLSNTSFSSLNSHQPAAVTSKYHGKSALRKSLKEKSPASVERGMRNQGWVGGHTPHGSQKPRRSYKLKNPSDEIYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYS9</accession>
    <name>A0AAD2CYS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S49 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS8039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYS9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047272">
        <property type="entry name" value="S49_SppA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42987">
        <property type="entry name" value="PEPTIDASE S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42987:SF4">
        <property type="entry name" value="PROTEASE SOHB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042242286" description="Peptidase S49 domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S49" evidence="7">
        <location>
            <begin position="353"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1942622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="576" mass="63466" checksum="2B12F9EF30D0AB0D" modified="2024-05-29" version="1">MKLTLLLWCAVLLLQQPFCARASDIESENSHNSSQIDDADVSPIEMNPDFEEYYGSEDSDSDSDSDSDSDSDLSDDEADSKLNPKKLAKSSISAALKKKKTQIAKKRTIITLALAVFAFRREILYSILHFLNKLFVNPRTGKLNLSLTQILKLVLFIDLMRKLQNTSGMRNGSWMNNSTNTNSKHAIEMLGLMNPLFGILVKSLITPNPAYIPSLYQHYTFERVNERHLKDGLALHKAIHSTHDEFKWPSSQSQVYENIERPIIKMPDGKKSNETAIILDLTKLGPSPSEDIRDKVSFVLSQYRHAAMITKDNISTGIEIVVILESPGGSAVDFGLAAQQLLRLRNEPGVLLTICVDRVAASGGYMLACTASPGRLFAAPFSVVGSIGVIGQIININELLERSGVSPIVFRGGKNKAPLGLIGKVTKHSIAKTQSMVDDTHRAFKQHVVDSRPILKERIENVGTGDVWLGSDAITLDLIDRITTSDEYISEKVSNGVRVLKMIKCPPRSLLFGRQLPPGATSMQAGSISALVQGFLAFVKNTVAMNQDPRILFREGMDSEKLPIAASTMDTPKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZ49</accession>
    <name>A0AAD2CZ49_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS8322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZ49"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="44"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="259"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1943192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="59935" checksum="F370F8771CE4DD50" modified="2024-05-29" version="1">MVEAYVAIRDDSGIRSLSVNERDFLRTCVHGNTTLRIDGRTGQELRRVRLQLGRWDNGAECTVQWGNTRVSSLCSAQLVPPSPDRPNEGMVNFTVELSPMAGSSFRQAPVVSTGPLPMGARGPNYSDRNQRLLANRILRSVERVIILGGALDTEALVLAPGKWVWRFTIALTILDDGGNILDASILAAMAALRHYRKPQVQFSGDDEKESGAMSLPTMIPSIVKEATPLPLHHTPLSVSFALVPADNSSNAGSTSTVAAIADPTDREELVQHGTVTIAMNTHSEVCLLDFGGGCEIPPSKLKECWKIAQTTTKQLCQFLEQTLQDANGKAQQERLEKLKQQQDGKFATSAASLPPNAPYFEQSKIGDEMNVEVEVDVDHIAEVEKKAEEAYRQQALDYSRGHVASKVREDSTKEKSSQQKGKSLIAAMLRSVNQGDKGESTRRSEEYASDVAHSVVTGGKQRQVTNREDSCKVVDKTKNRVAMDLNDDEDEEAPTILQSEFHSSSREEKAPTEYALTPPPNTNDEANDLSMAIKKKKKKAKKKKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDN4</accession>
    <name>A0AAD2FDN4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000305">
        <property type="protein sequence ID" value="CAJ1933840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDN4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="51211" checksum="3CCFF50608959B01" modified="2024-05-29" version="1" fragment="single">MANEFLYNSDRAKYQSRIDGMTAQYTLKHLDFKQRCTFPTTLENAADVLNQHKHDNRKKNSNGGNSNGQGKQNKSNNNQNDGAQFTQQQTRACFVCGSKDHVAPQCADKLKPREKWKNPDKYRDYSENGRGNRQNMQRDENATRDDDESGDSNTQWNYGRSNNGSHGGQFIQRGRTDDDPRPQGIMLFQLNNYRGIHLDSGSTFHLRTNEDDFKEGTLQGIDGGFHYTSNIQGRRLYREGIDNIFDSVCKLDTQASDNVNSLSNMVKDGFDVLMDTKRENSFFVTRNGTTWRFGHRDGLYTLVDEPAVATAMFHNHARGIDNAGVDPRFDIEIERYKGMAFILQRDRINMGEPMNEYYDLWKWTKFAQWCYELAKDRRWDFDGLDIFARLPDTFAEEAKRRGILKDFHEWTDGRGFIFDEVPAGMELDQIHIVPNNLNDDMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE91</accession>
    <name>A0AAD2FE91_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000213">
        <property type="protein sequence ID" value="CAJ1932181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042237292" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="59170" checksum="85691D04ECEF4091" modified="2024-05-29" version="1">MKSFGLLLLLSASQVAAKLGESHAQQANNADQQERRMALQFHGSNPSFKLGRCEGDCDRDSDCFNSNGEQEGMVCFQRYNPNEPVPGCSGGDSDISLSDYCIRTSDLNRGTPTNNNNNNNNNNIDTSNNDNANVGKSATTTTTTAAVPIKWSTNFPLALCEGDCDTDFDCQGGLVCFQRGGKQSVPGCLGAEHDWSMTDYCVPKPGSNPTTPQTGDLKIEWSTTFPLKRCQGDCDSDIDCQGNLKCFQRTGGMTVPGCIGAELDSSDVDYCFDDANRQGPPGPPANPPAPTNPPAPVDNGRTAYYVGDGDFSGNPLSVCQGDCDTNADCQDGLFCWQRDQDEAMPYCTGAAGAIDYCLPKSESPGKKIRLYWDNYFWQETFEEAFWCMECTACDTLTVGDGWEGGCKDPPTGKCEEGHLIWIQKCKEVRDRFDIVQNSGSGDQIRVHGTNLCFTNRENRWLELRPCDKNISNQLWAPMNNRGKFEIRPWYQRSFSSKDALCVSQLHHPKATEVLSMKECWLNIHYETNYWTEWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF42</accession>
    <name>A0AAD2FF42_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1898029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1898029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="375" mass="43408" checksum="931FE4E6675C04D6" modified="2024-05-29" version="1">MSSSSQAPFSAASPMYMDDGTQSDLSDDDDDDSYENPPAFRINQKVLCRDVSNGAHFYEAKVIKLKALGNDEWEFFVHYHGWSSRWDRWVNAEDLCEDTQENRALYLQKKDIAVQQHQAEQKKKRKEKLNDSARKKRRKGDENMPPNGEYTREFAEKRIAAYQGYCELPFTLKTVVVDEGDKVTRKGYVNPKFYDHNSISLPPRSVHNLPATVTVQQALLHYQKKRTGSAETESKREQIKAFCHGLGMVFDSALPLVLLYPEERPQYNSLQNDPNCKGKSPCQIYGCEFLLRLMIRLPTLLIAEPVHLMKINGPLIADLIILLQKNRQTCFKPKFRDPKYCELRDWEQQLVDQQEQKQQQERNNQTNKPKVADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGW8</accession>
    <name>A0AAD2FGW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Right handed beta helix" evidence="2">
        <location>
            <begin position="354"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="526" mass="58296" checksum="DC1709C4AEF27F72" modified="2024-05-29" version="1">MSLVQQPQPVEATQSRPVPQNLASPKSPSLLKRMMSARSSRMSALDSSSFSLDDSERFMLPPSTSTALTSPLPARFFRPKKLPCCDPSSSDLMEWLQGDCPQDLLPKILAFAGPQMVSKLSQTNRFWNALVSQEQTWRTLSEELYKWTEEDETPSCWRDYYRYNPCVPVDFPSITRALASATTHKHLQNRSVRVLMRPGRYILKEPITVEANHGVSVTVETMDLPDSFNHVIEYPNDEKPKKRKTSLRKLLSCRTVDADDEDEPPLEFPERSSEFGMVLGKNRAVLTLRCKKHNQPLVKVRRGSCVLRNLELRHITYGLDIWNGNAAVQIQPPLSPDEQPIPVAPMPTAVLDHVDVTSESGRGVVNIDGGDLSIRNCYIHDCAATGVYVGAAASKLTIQNTDVVRNGNGNRQHRRGIARGHSGIYLEQGLAEINNSSISQNCLTGISAVSPSNAILHLSESELVSNGSTQLEMPDIGTLAQRNSSTRDVHLSNVDSPRLRSALVEEVDSMMSSSIMSSELSSEFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJY3</accession>
    <name>A0AAD2FJY3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJY3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="313" mass="34025" checksum="4F40C3960F5BA921" modified="2024-05-29" version="1">MRLPSRHLGYKRLFHRFALSATVLSNRSVLAFSSMSTHSTERADGTITVAPRNEAAQSALIVICHGLGDSAEGFADVAEMFAAQMPYAKFILPTAPTQPVTMNMGMPMASWYDIVGLDERSNEKCKGLPESRARIEGILKTEHETTGLPYSRMVLAGFSQGGALSLFTGLQLEQSLAGVVVLSGYLPAASQFKPTQLSTPVYHGHGTMDPMVQFSLAEKTKAAVMAHGVTDYTLESFPIPHSVSPPELKKVVEFLSKVLPSDDSFKIQLKDPKDMSVKELKAAIRKAGLGNKAVGLMEKSEFIKLVQDHRDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKQ9</accession>
    <name>A0AAD2FKQ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cystinosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS9742</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKQ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1945598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40974" checksum="D22486460C50ACBC" modified="2024-05-29" version="1">MAEEHTPTTDEPITTDDNEIMNDSNDDMEQEYQVEISEAQVAEHQSVPGFCYRALSMFAAPLLDESGGIMAVLAGLFSLFLVGTTIGLIMPKNQDLSTEWYRTTSACIGWIYFMCWSVSFYPQVISNFKRGTTQGLSAEFCGLNVLGFACYSIYNGAFFWNKTIHELYRERHGADAEISVQSNDVAFAFHALLLSAATLFQIGYYDGVRAMMPSKTILGILIALLCVCTFYPWLVVFNIGDHYNWLDYLYLLSTVKIMISLIKYIPQVILNYQRKSTAGWSIWNIILDFTGGLLSDLQLIFDCKDLHDFSAITGNFAKFGLGSVSIFFDIIFMLQHYVLYRQTSEAVDERQPLLSDEERNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL78</accession>
    <name>A0AAD2FL78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000819">
        <property type="protein sequence ID" value="CAJ1939618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17619" checksum="CBDCFF958E3CBF4D" modified="2024-05-29" version="1">MKWMINASFAVHPDFKSHTGGTLSFGGGAAQVMSKKQKLNSRSSTEAELIAVDVVVTMILWTKLFMKWQGYPIDKNILYQDNKSAILLEENGRKSTGKRSRAINIRYFFITDQVEKGNVKIKYCPTDDMIADFMTKPLQGEKFCKFRDLILGPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLH1</accession>
    <name>A0AAD2FLH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7285</name>
        <name evidence="6" type="ORF">CYCCA115_LOCUS7287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000979">
        <property type="protein sequence ID" value="CAJ1940940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000979">
        <property type="protein sequence ID" value="CAJ1940944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1940940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1940944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="155" mass="18131" checksum="FD965C346B5FCDBC" modified="2024-05-29" version="1">MKDAFNFYLSSCRIYIECAFGELVMRWGILWRTLHFRLKKCMEIIRVCMLLHNFILDHQEESERYNMSEVQNFDIEMDQLQQNITQATGEIPLPTVSDNNEPKPSGRRTKEEVNEKALGENIRFNLAYKLASAGLSRPMVTGMHTNKHGHVYMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP15</accession>
    <name>A0AAD2FP15_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP15"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12748" checksum="A5906D28F9F93B0D" modified="2024-05-29" version="1">MSVAAAAPPANAAAPPQIQYRDIMAECQRLMQKIAELEVDRNEHLLVEETLKPLDPSRRAYRLVGEVLVERSVAEVLPSVTANKDNLNTTIAALRQRLTIRQKEGADLKAKYNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP87</accession>
    <name>A0AAD2FP87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="695" mass="77446" checksum="7B963D6C819A9F04" modified="2024-05-29" version="1">MNDDRLRSLSDTSDEDESENQTENENKRRRCVFIYVGRNSEKLKQGNDTVTQHMVIDSCVSVIGKSAFQDCQRLVEVIAMDGLTSICESAFESCTALKKILVPDTVVEVGNRAFALCSALRDVEFPKFGSLSCIGEEAFLQCSSLQFFPVPSSVAFIKARAFQQCTELAKVLFEEELDGMNKSLLICIGDGAFEECESLGEVCLSANVMLLGKRAFTGCRSLQDADLSKTKLTVIEEMTFSHCRWLQTAKMPPTLGKILSDGFASCRHLSELVLNEGLKVIGQHAFCDCDSLIKFPTPSTLEVIGQDAFSGCGELKDIPVSQNLKSLGGSAFYQCHKLSTKMSIPAAASIEGGTFFNCYSLVELQLAIGLQRIEDDALRNCTGLMGVSLPMTVKKIGSSSFSGCISLLVVEMSKHCSEWMEWGDHAFFGCDSLMNISIRSSEGSGTKNPLYANNKNEGDFFDGCEEKDQLFDNVAESLLNRYSNLPVHEACYHDSETMGDELTQKILDLQASGEKEELVDRFGLTPFHVFATSANLREDLLTVLLDHYPIELLFQKDKQNNTMMDYLLIDQRCTKSIPLIKMILNRIKAYLSSVGLEKKWEMKRCHKILSEDGWADSYFDRLAAMQELREVVEYVTRIEVTSILELALWKRMSQCHSVKSVGRVKCGANVVIPNVMAYGSTEGPVERDPFREPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPH0</accession>
    <name>A0AAD2FPH0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="165" mass="18758" checksum="FC49AEDC439004EE" modified="2024-05-29" version="1">MQETFLHLFQCGGLESTDPYESVTQQKKVFWEPRASSRGQRIGLSSRPSSPTSIYYIPSREKMIEIRQDSMNRSGRSGLFSRTTSSTPMRFSFEDYEYDMEEGANENENNSIRTFSIRTNGANQFSHPVKRVNSLSTVTTADSASVMEDLQQDEAHHIDIVAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPT8</accession>
    <name>A0AAD2FPT8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11607</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="379" mass="42411" checksum="919FB0A46B5D8EE7" modified="2024-05-29" version="1">MPSTTPADNSFVTPSKTVDFSGENPEETDNTVDENVAAALPPVVHDKFTKPEALLITKIVFNKENPTKPMFDALQTFFDHIGVEKPSDLEGQDVDDLLSHGEDALPDGGLIRGVITGRLKKFLLYASAPSVVIDPSLTYQKIVQFSIDQAKQNIPTTPIDLTKAIGERQGMKFRCPEVEPFSGESTVYWPWTSKVALEFGQSGIELALTDAKFHEQSTWHKDASSQGFYAIAKALNDGTASHIADEVKEKRGQTVAYDLYQRLLETYNSPEDQAHFVMYAIDELTSIKLTHEVTVPDFISNWKSITTRLRKSNQSLATSRELLRVFLLKAIVSDTYSDMRRYIVKYPLASIDEYLEQLRSHSKTQALIDEDSPVRACIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQB7</accession>
    <name>A0AAD2FQB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS12094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val/Trp_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="LEUCINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722:SF1">
        <property type="entry name" value="VALINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042160711" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="190"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1949438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="807" mass="87403" checksum="09CF354CDB693AEA" modified="2024-05-29" version="1">MFIRILISSLLLSGALSLVSFSVPQRGNAIGTPSFGELFNVVETPNKRGATVLEAPVRQDGVKLYIAIDSDSFNYKERPGNGGIRLLNYKSTQDAIDDAVRLAMGMTRKHDMFRTGFSGAKVVVDTDHANLETIDREALMKDAASALKALEGQMYTGCDLNTSDEDMDYLVEATDDKFVLAGRNSRVDTNVATASSVIGSILGVLDCMDDTDFSELTFTVQGCGKVGSTVAKELVARGAKCVQTCDLLMEATKIPGCTSIEDWTNTPCDFLVPCANSLAITENVAINFPDGLKYCVGAANSPFSSVEARLIFDARGVMHVPESISSAGAILADSVEWYDINLYQNVQPELMYGWIRDQSKAKASDLVNKADKTAKSVQAVIGDVVPNRSGDPVGKDFPEWIKENTMKTDTLIVGGGVAGTATAFSLGQRGIKTVLVEKGKSVAPADASSNGDSRMYRKMYSSEFFSRMQSQALERWDDVEKESGEKLLQENGLLFYGEDTGETVEGSVLGAKQVMENLNLPHQFYATGDAIAEKYPALSGCKGKDYSGVCEDTAGHIRASKACHAMVKAAGDTCDVHINSKIVSLDVSDSAVDGEYTVKAVKQDGTTIQAKNAVLACGPWTNDVLQMASLPRIKLDIWMVQWAHYEVDTEIGASIPQAFHFKKENGIDGGLYYIFPSSATESLESKDGKSYVKVGVDFPTFEALNSMDDFNYEGSEDVLSLMDAWVNEHLPQVGKRINAYTSPYTMTEDSYFIMDKIAPNVAIFAGGSGRGFKFGPLLGDCMSSLLHNEDGPVDLKPFSLEREALKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQV6</accession>
    <name>A0AAD2FQV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="25"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1949875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="282" mass="31050" checksum="63141C40346EE1E3" modified="2024-05-29" version="1">MQAALSRLSRLSAVGATGVFTVSQCLYNVDGGERAVMFDQLRGGVRPDVSGEGTHFLIPGIQRPIIFDVRTKPREIPSVTGTKDLQMVNIKLRVLWRPMIDELPKLYRELGTDFDERVLPSIGNEVLKSVVAQYNAEELLSKRAEVSARIKSEMIKRAKTFHLEFDDVAITHLTFGREFMNAIEAKQVASQEAERQQWVVKRAEQERMAVVTRAEGEAEAASIITKAMEKTGNAIVEVRRIDAAKEIAGKLANSRNIVYLPNTSGSGNGNGGGANLLLGLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR23</accession>
    <name>A0AAD2FR23_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR23"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="797" mass="90786" checksum="B5844F3AD06ADC55" modified="2024-05-29" version="1">MSLFSNDSSLQTEDMPDRLMAILIMHRQDETENKKSNKKVSKAEARKAEYQHSEQAKSKAVAKKKAEVKKKAAAKKKAAAKKKAEAKKATKKAAREQEVDESESEPAMEEETYEPIAALAYDDDEEGPRTEELSDTLKCGFAYNEDDVEKATEDFDDLDTIKKVVGWLSSNEEYRPPSDKKFNADTKKAMKVNKAFGAYKVESKELSAEKKAKELESSLKWLQDSTTKYTEDAAEFEYNQGTFKKVNDLFGQWAPKGVPSLDWESYDIREDPNDSESRANDLKGSLGLVLSGAFDTNHPNYNCATINRIKDLFAGWKLKENDGVEGLDDALSWWKLNATKYDPLTASADEIDMYFKSKKMLAMFGLKEGDEWDKRNQEIEEAMSLWEKYKGKPLDDLDEPTVAKMKKVKDALLPMKRDSLGMCDMKYMAKEMDDALDWYLDKGYKIEDLSKVNKKYRSSFKKAQALMGLWGKKADPSPDLLKEIAESLLSFRRNMYNPEIIDKFDGEEGAKCKRLQEAIIDWRLKGAESDTIASDEGEALAHGIENAMDWWVANGENFDFETADKGQIFMAQMAKSTLEMWIPLGPEDAFTYKKSRDAVDEIKEVLALYHDTGKNFDVANLKVKSGERASLLKLKHAMLQWRRGNATNISQVESEQTVNEMISAMNWWKHKGKDYDVVADRMETVPVMLRHKEATNALEEFHGDFGAPGQTPFKCLSRKEQKKVVKELDGSVSWWQRSGKMIDTTQAEEDFEMFGKAHRLKANMTEDEREKLCKEISADIIARKQIAESSSYAVETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRR9</accession>
    <name>A0AAD2FRR9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="68"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1950774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="358" mass="39462" checksum="7C54660B6A934114" modified="2024-05-29" version="1">MSEQEAASDDFSGLTSFFFYTFIVHPCTAWILRPGRFERKKSIMYAIAFLAALAAIKTGMEFAERGPNHYSLLGVTRDSNPLEIKRAYRKLSVQLHPDKNDSPDAADQFDKVKQAYDVLMDLELREVYNKFGNEGIQQNKRYSETQFLMEAGIFYVSWGVMTFFLTMGKKSGQARDWTLTGLILMLVVEVVVMTSVTNPLPSSIFPTLTEADLVRVLHSLFPAFMNGCRSMGAYLYVDLDAQLRQLLLALQEQNQDILLVLRDVQIGVQTIQSSGGGGGGGPRLATGPISTSNIPVATDGGALGVTPTGKLKELQARLHHSNGTVAQAVQSLKQEQKSSGLGFYGMILGYIVISYLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSF1</accession>
    <name>A0AAD2FSF1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="188" mass="20273" checksum="1478910750B64FD6" modified="2024-05-29" version="1">MVAKLPKGVGELPEWWMELCPHNIYESPEETARMQAAYEESQIFSRVPDNFKQQYGGDAFPDWNPAEHGPMGDEMTKDWEKKGYKRDPASNKWVGKDGQPLVGRQFTIKPPKGYVPGKSGGSGFGGGGGGLKSPSGGGGYANDKTSWEKPAWTTKKLRSTGKSPAAKTTPAGGANKAPGKVAKPSWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSL1</accession>
    <name>A0AAD2FSL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSL1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051760">
        <property type="entry name" value="KMT5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167:SF1">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="91"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="263" mass="30182" checksum="07706629BE5C0DC8" modified="2024-05-29" version="1">MLDTLLKNSKRYTLVLFSALFIHPAWSSFFLANHQRIHHDHRRDLRAQSRNNRRPLEWSSSTLLSLSKHKSQHRRPPLSLESPSRASAKLHKIRIAEAGKKGLGAFCLQRIESGELVGEYKGEILTRNQVEARYWGTRSKQTSDRRWIKSRKKRDQGLSGDYLFELGENKFLDGEDADISGWCRFMNHATENSKACNVETSYSVRKCTAEAAAAAEEARIHGVVYSSDLEAAEPRVWFVAMRDIEAGEELSYDYGDSYWDDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSP5</accession>
    <name>A0AAD2FSP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS13341</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1951992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="262" mass="29663" checksum="C9DBBA9EC3F859EE" modified="2024-05-29" version="1">MISLRTVAARGINRLPSVLAKGQSKRTMVIPIKKALVKAGETEGEEVPALEKRMEDMADKDPLMVYDSGNELADPILPDDASEVTALDPAHLTSQRMPDGRMRMVVIKQMRARPNQAPLNPEKVWKISFNDDGAVSERWKNSLMGWNSTADTMGCDTPLYFRDAQEAVYFAEKRGWKYLVKEPVIRKLRDDEAQYQDNFLPQAIASKVQQEGKQCSHWERKAAGVSHYFRPLKYHGDGVVRQHGPNAHAESVPHTEGYYKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSZ9</accession>
    <name>A0AAD2FSZ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS13451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="4">
        <location>
            <begin position="482"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="5">
        <location>
            <begin position="570"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1952236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="91955" checksum="6F5E00766B95AD68" modified="2024-05-29" version="1">MNHIQDQKLQSLLNTWKGSHVIDDDGSNIIIYKPKRKSKKSKQEPSQESHEDFSRRASRNAEMDHANHGYASLLPNASQQRRSLSPSMNNRPDEASASGPKKKKKKKRQSLPETQAIHQFSSEQNDKAQPVAFDPYNDDFDTGDRKLNQLNHFPNASSNQDHDQEQPSGYPELIPIKRKFTTYKMPVAPEPVQPMNANGNGKSNIGNNSKSLGCCGSLAYRMRSTNASLFRFKWLKLTQLLLATYIGILTFADMGPPGGLRDTETGLIMDKASPERTAKGLILVNGTERAIVAASLTQVACIGVARLSAWLMYPTLVMVFFTKFRATIGFLSTTPIGMYMHSDSHEVHVYCGWSILILASIHSLAHLVRWTEQGNLSLLFYHFSGLTGFFIISSCLLICIPMTLFRKRIKYEVRKFFHYLFIVFALALCFHTPTSAIPNGGFTFWVFGTLLVWYFLDFMFCQFFMTEKIETTKFSVLPSGVRVTMEVSERFQKIGAHGGICYICLPWVSKNQWHAFSLFENPENPAERQVFIQKTGDWTTKVHQILQRDTVRPAWIHGPFPSPYDNAIDYDNQILVASGIGITPALSVIRAHKNSRRINLIWAVRDPHLLGFFLRHLYLDHQGWNLIFYTGKEKLKSGLLESIANTNICIIEGRPKLDQVIPNIIFGIESGHGLPEWYNQDTRAVASEMLIDRLKHADRPEDVAFYAQELGFNLPADAAHTSFQISRSSEGCDIDSSRNSTSEFVMENLGIGFRPWEYHPGATRYIRNLDKKMVISTWGMLYCGGAKPVLNDLKRISDEYHIGLHVESFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT48</accession>
    <name>A0AAD2FT48_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001774">
        <property type="protein sequence ID" value="CAJ1950988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT48"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="287" mass="32342" checksum="9C8F695C35ECE4AF" modified="2024-05-29" version="1">MLVYSCFSAYAKELMRLFDFEVPIGIKMDWVSILYTRQAKYNERSPGLTSPHCFTWRIHAKRADRTLRLILHPASAKPDFPFAAPATYISDWKSAQQGLLSVKAYGPVKDAILTLISKLRDYYILTEVLYPGINFTGMFKFATTRLYGSCTLFKLLLSIEATPAQADQAFIAGKDKPSPTTANDDSSEEEDNNESQEGAVSLSGAFTKVTKKKKKKKKKKLPLSDNLKNHFLKDLSPAQRKLAEATDRKLQNNIDRHKAGPLFLMILPGEMEGSYIFVCHKKYGQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTY0</accession>
    <name>A0AAD2FTY0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS13785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTY0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF21">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1952925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="286" mass="32797" checksum="9D6C3C14868346D3" modified="2024-05-29" version="1">MMSTKHNLPGAVNTESNSVYADENAMASRSRRRNRRRHGAAPRQLNPLKPQYCNLVNLWREADAKKSHPSEWVIQQYANFHQPFVLDIGCGEGEWALKTAQECPDLNILGLELRSEALTKDRRRQAQEMPNLALLDANVLSGDLKVLLQDIHKVGGNVAAVMVQCPDPHWKTKHRKRRILGPILLQTCYDCMSLQASLFVRTDVERVAQDISILSRHLFVEDAPDNLLERLCRIPTERMLYVNRKGGSMYQRTFRKRSEPLPPSDDENDEQEDFGSEEPLFGVYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU75</accession>
    <name>A0AAD2FU75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cysteine desulfurase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24138">
        <property type="entry name" value="TtcA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686:SF1">
        <property type="entry name" value="AMINOTRAN_5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686">
        <property type="entry name" value="SULFURTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="79"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="383"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="3">
        <location>
            <begin position="947"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1271" mass="141936" checksum="CCBA41209FBB7514" modified="2024-05-29" version="1">MISNDKDDALILENGWSLSERAHETGPLHDEATPTSDVGSMAMDEVRESVAQDMLGSGTSFSSPLEWKAGDAVKVPLVYCDFTASHRPLKSIEKYVENTCMPFYGNTHTNTSITGSQSTAFCSEARQIIAEACGAKITGKASQDVVLFAGNGTTSAIQLLTDCLGLKLYKATDEKPLIILGPFEHHSNMLPWRELGFDIETVNLHDGNVDLQHLEQILIQEAYRSVKIGSFSAVSNLTGTIADDLAITALLHKHGALSVWDYATGASYINMNMNPTHPDYPDPSLLAKDAIVFSGHKILGGVGTPVSLLFVPMLRTQGLHPRRCRDRKVSLASLHKFPLQKKAVILFETIASIFNSCWKILKVIVFKGATTILIIFCFFCCKGVLVVKKRLVSQLNPPAMSGGGTVFYVTKHSHRFLSNRVERYEGGTPNVVGIWRLGLAWQFKQRLKKMFPAGQTLEEYEIKRANTIQDRLKEIPNLMLLDGHFDSRKVPVFSFLIKCGNRFLHYNYVCALLNDLFGIQSRGGCQCAGPYAQMLLGMLEHNQAVQHWLVHAKDESLRPGVTRFSLPSLGTSPEQQEYVLNAIAWVAKHGWKFMHVYCCNQRTGEWRHKSRPGAPLGKKERRWLSHYDPFRSKQADNGDGAAPNYEKALENANILLQMVLKDHSSLSQTLKMTEEIEEKSLRWYVYPKEVAAFVQEGAEDVPGTFDRNLLVGAMRPISWFGSETPENMSQQQKQAESARRCRFKDGEHIGDAPLHEIIEGYEDGELSELCQIYNPNADAWELLQHFMKSQSQLAPSLSSWTGDKAPTSDHKEDGSNDSLDTNEKAADDSTADCTSGTGSSTADTMHADEFTTAKDASQTMESTPSIFAELEDLPVVEKREKKKPSRDSATWGQGVKMSLQPQISLEERTSDATRRKGSKHVKPPAKLMRLVTQGLIQWDMLQEGDRLLLGLSGGKDSLSLLHILLEFKKKLPINFDIEVCTIDPMTPSFDPSPLISYVESLGLKYHYIRDEIVERAMKSGKDGEVVKSLCAYCARMKRGNLYSCARRNNCNKLVLAQHLDDLAESFMMSVMHNGFLRTMKANYKINAGDLSVIRPLVYVRESLMTEFAKSANLPIINENCPACFEEPKERARIKKMLSREEALYPRFFDNIKRSMMPLMHDDATAILRSYTEEALAKSRKVDKKKGGKNQPSKETTASTKESTADPKKAMRLQDCSDQELIRELARRRAEQFRLAGASPGNKREGLPVDPTGQVCTLNGGDGSIPCRELME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVG1</accession>
    <name>A0AAD2FVG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS14918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1954326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56154" checksum="7E0A980AF96CB6AD" modified="2024-05-29" version="1">MTKQDTQEQLNIAAPDLPRWYPKWRGKPWYDGNQEALAWMFDGIARNVSFLGAGAFFATALLRLAKESLGCATEPLEGSIVIPECEGRVLGIKPSSLLTTYTMIIGVASALFLPLMGAMVDYTRHRLLFGQITSAIICLCIFPQIFMNEDNFIVMAILQVISSFVGWAQTALSHAYLPELTDDELILNEYNKRYTVVFFSFGVAFLIVTIAITTVIGYADNDLVTSQVAMSMAFVVNATLLPLAWGRLFKRREPMHPLPEDAFLWSAGFVQLYRTGKKIAGNYRGLKWFYLAIAMSDSGINALATIAITYNTDVLQFSALENGISLIVILIGCTPGAFLSKYTTEKFDPIKSSIFALLLLIVATALFAILIVRPKQFAQTYAIAFFWGMGMGWKWTIDRTLAALIIPEGQDAELMGFFLFSGQCLSWVPPLVYTAINEAGVSQRVGLASLDAYFILSLICYLLMGGYKQARIEVGRDKNLEKELKEMPGAETPHPDCDAIPNPNDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXZ0</accession>
    <name>A0AAD2FXZ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="609" mass="67199" checksum="6668C6B4C199A8FD" modified="2024-05-29" version="1">MGGSQQVPKDTVRAHIHPTVKKIEPNAFSDCKELRFVEFSDGLEVIGHRAFYRCAQLAFVRLSSTTKKIETGAFRSCKKLKHVLFNDGLEELGTSAFAECKALQYLAFSSTIQLVGQGAFLGCSGLEKVAFNLGLEKVESGAFSNCRKLKFVYMPSEVCFLLSDAVPDEVIIENTRNEKFWTKVAVAAEEVEADLVEQYRTVESSEGGPPENDTSDLVHASELAEARKEIDMLKGLLNDMKRKAKTTEEDLESAAKDKDSLVEEIKKGRVQLEGALSLAEELQEELTFVDEQRQATQELLEKALDQRDELAEAKNMLELDQPNMVDVKDFEEHIDFIEAQAEETRKEFEKTARECAILQKENTALKKKNKQLEQVMQLRNKEYMDLLSRHVEAKLNSMEAAPEQVLAAVQSPKTPSKKKKAVNAVKSSQTPSKKKKASKKKRPSLSPRATKEPSDDSVKSKKATVGIPAPELVEIVKQPSADSGKIEKATTGNSTVHITEIGKEPLDDSGKNKDSMIPLPDQMQTPSDPVGELSDGALSESEFGSEHDILDDLEPVAVISENVEPDDDWEASSHQSSCHESIDWLGKSHGVIISADGADDSGGNDLFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYE9</accession>
    <name>A0AAD2FYE9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS15251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYE9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="77"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1954660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="292" mass="33184" checksum="A5B7B60FB6D48F87" modified="2024-05-29" version="1">MCDPTAMRSSPQHVLKGKTTPQATKQISGFDACRRQIEVTLLLMAICYSVMVSLNIPIAPNAELCPENEVSCERPDLVAYKITSFIVMSYMGTMGVRNWYFSKEVHDASKGTPEDRLFGYLKAANNQNVANLSYQIWDLCVSVYIPEHREPVFLVHHFLAGMTAFCSLEFQMVPYYSVFYAGCSEFSSIFLVWADLKDFIPVKEGSPLDTFIFACGALFSITFFCFRIIGWIGYSFPLWKDVIHVTKTGSAAKHRPGKERFLYFFLTLDVMLGVLQLYWFREIVQMTMGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYV8</accession>
    <name>A0AAD2FYV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="107"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="411" mass="47049" checksum="10A784D262E1F4D2" modified="2024-05-29" version="1">MNVSATDLYPVVQDLTEVEYGCCSSAEMVFGSFSIQDLANPNAMPISPSPRNGSRNNYLSPRLSPRSVLDREKSLIDSLDERANKDREGVDEMTRRDDLNSRFEDTFVLTRQICSCRISTVWECVDRSTGVRRCVKVVDRRKFTSPQDEDTTLNEMSMLSLLRECNTSPNIIQAEHLSQDQHHFYIVTNLVEGRSLASFVLQERMPADKVRLFAKSLLENVAELHSLGIGHFNLNPENVILRPDFQVSLCDFGNAAFVEGMEHRSRQSKLAYSSPEDIKKMPDFASDLWSIGVMLYVCFCYHLPFRDSSRAKLKAKICRHSYDFSSRHWNLVSRVAKQFISSLLHPDPQIRMTAQEALNHPWLAVPDKKPKVKRRRRGRLMEQVLGRLKRQSQHDSNELKTTPTFSSNESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ86</accession>
    <name>A0AAD2FZ86_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ86"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042117968" evidence="3">
        <location>
            <begin position="23"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1957913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="288" mass="31516" checksum="76BD9F3156D01547" modified="2024-05-29" version="1">MFANRMLVASTILVVLLTTVNAFTIQIKDYECQDKAIKADFTDICDNNMTCSFGQTAYISGVLNMTNDGSISSDTMVYLDSRLHIATYQTSLLKMQPIYLCNQYMTDYEGRRELAQSSYGTYGDEYETNNNSNSNGGQQEAQQTSYNYGGYSSGSSSGCPHSGLYSFDNVALQLPTVPNKVYDWVATGWTGSISVDMYLDSSKYQLIGRCQLNVVTHMDDSYSNSTSTNSLVNTVMSAIPEAGVTGMIILGTFAACAFLGIVGYAMSNADNNGDDMDFKPMKHHVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZG9</accession>
    <name>A0AAD2FZG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16382</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16515</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16519</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001934">
        <property type="protein sequence ID" value="CAJ1957032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001934">
        <property type="protein sequence ID" value="CAJ1957040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="17661" checksum="D7822DEE2FB9A29F" modified="2024-05-29" version="1">MCRPIQEQAFQSQPNLIKKLGGESEMGFLLMNFCDSINEDADLQMVFGHMSMTRLSAVMSSLIKSALESNFVVDGDARLRVIMKNYAVFELGINTKQFKKLKSHFETALQGSWIEESILEECTQRFAALRIIFEEEGKDFERTAIATRVLAAQLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZZ4</accession>
    <name>A0AAD2FZZ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS17317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="235"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1958720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39087" checksum="5F37B46EFA740DB3" modified="2024-05-29" version="1">MYSDLFDALGGGGAASNSSSSNANREEVKPLLSFKAGKVNLSLQENGKYWAAPDTRRGQVNLKYNDEDQLTWEWYDRREKKVQDTIIITDPVTLERTDVPKSTDADTNDRVYYWKLDNVWRMIWLQDKEEDKELIEKVNAILKKPKKPAEAADAAPGNGPVSARSPGNASTSSASTTTRQVDALSNILENLGTPSGGAAATASAPAPAAAAASAAAGGGTLTLADLQGVMAGLQTQPQASPAGLQDVVSSDAINSLLENEDVRNRLIQELPEEQRTAEHLEENLRSPQVQQTLRSLTAALMPDDNGNMDGYHSVLANFQLDAADGQQALTQSNNPIQAFLDCVLASVEKEKKDDSKDEEMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1J7</accession>
    <name>A0AAD2G1J7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1J7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="203" mass="22924" checksum="8EF5B5A0D3D7F9AB" modified="2024-05-29" version="1">MMMMIREEGPSTPSEKRVSFSQDVLLYVDNKYSLKQRRDMFYTAKELKTFGNEVYTQIQLARAIGDRVVKNLNRDCCYRGLELVSDEASSLGKKRRKHMGELAVFMEQDRQFLEDRNVCPIDFDAMAHRYGNITKESKQLARERGILYQEMETQQVSSSVLAAPSSSTSSKTTKSSKTSVPRKPISGCPVAPRSRHAVGPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2F7</accession>
    <name>A0AAD2G2F7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2F7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234:SF5">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041942710" description="Serine protease" evidence="3">
        <location>
            <begin position="23"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="727"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="797"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="95747" checksum="104337085C3B065F" modified="2024-05-29" version="1">MKALHYSFLFGIWQSVLWVALAAEDGNIFNHTARAPGPFQIGEEALLTVSTDHEISEIQPMTIIKEKRVSHTYTVYHEGATYISLHFASLDIQGQCRLLLTDLVGKEAFALRGKGKSGLTSFWARFINGDTVVLSVTCAGDNGVGNFLIDKYAAGFRDVSSPRKEIDRPSLRGVELLPWEQRRDLTICGADDLRNSQCYRDSHATEYKMARSVAKIIINGRGTCTGWLIGNQNILVTNQHCIRNSEDALNSYAVFNLEVQNGGGDCSGSGKDSVPSDIQDVYEVDFLIEAIRLHDYTLVKLKDRPTAPLKRYGFLETEPRDPTIGEAIYIPQHPRGHDKAMAIMDSQYGQEQRCRTLQPVVSCYGASGYLDVRYTCDTEPGSSGSPVLSVETNKVIALHHCGEANLCSGNEGVPMTFLHNRFANNAEIGLDGSLPPTQPTEQCQASQYEMILELETDLFGYETTWELRDSSGGLIAEGGKDAYLRSNESYSLKYCLEAGTHTLTIDDSSDDGMCCQHNTGGFNVVFEGEVVGTGGDFGSTASVTFGSNSPSERPSAAPSKSAAPSNFQSNSLMPSNTPSSFPSTTPSFLPSKVPSALPSTAPSVGPSKLSSTFPSLHPSQSPSTDSSTLPSLKPSEGPSQLQSSEPTLSNGPSHEPSIMPSTMHPSQGPSTLPSLKPSQGPSQLQSFEPTLSNGPSHKPSIMPSTSPSIMPSNTPSVKASDKPSATPSLQPSIQPSVSPSSQPSQTPSIMPSATPSAKASDKPSTIPSFYPSKNPSSTPSSGPSDLPTSGPTPIPTSGPTSKPTPVTSSNPTSGPTPLPTAGPTTSGPTSDPTSGPTPIPTTLRPSSSPTERLVIGPPTNPPVFNFITPSNGVGFDGPREAPNAPQPPVIVESPNFFQPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2L4</accession>
    <name>A0AAD2G2L4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2L4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="209" mass="23993" checksum="020FA16A8D95C806" modified="2024-05-29" version="1">MTIRSSSSSSWNPYAEQSSDKDDDESAKKNKKAPQHNQTTSSNYTGVRIDMAGQLLSGMMMNNNNSSNYDYNDIIGSGEEPMDSVELGMKEQEEQHRWRNDNNNNAKDDDFPIPPPPLTTSPRQQNHKETNTSTTTTDEEEGRNYAQAMELSVPPRTLNVERTNKELRLENLRCWKYQGRMVIVCAVIMIIFIFLSFYTREGHNELAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G312</accession>
    <name>A0AAD2G312_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1961021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G312"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="212" mass="24227" checksum="87A9FAF281AECDAA" modified="2024-05-29" version="1">MSSDEEQSWRSLLEVSIAKSRKTRGSNYVQISTVEEGEPRCRTVVFRGFQKTPVHHDLFHELDEKPCLFKMCTDKRSKKVAQNAKQSVAEIVWWFPKSSEQYRVRGNLILVGGENEDRALEIARKELWGNISDPSRESFLGQVVPGEAYEKDNSIIPVGGRDDDGKVLVPPDNFLLMLLDPMDVDYLRLTGDQYRQVDSRGPSGWTKQRVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3A7</accession>
    <name>A0AAD2G3A7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS18284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3A7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="357"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="917"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="588"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="743"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="827"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="840"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="860"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1959865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1046" mass="114922" checksum="88BF97C8774D8BDD" modified="2024-05-29" version="1">MRSLPASEAVLRNMKIAETARVKDGQTTSSGVNLEAEIAILRRQLLQATVENSRKDTVIDSLEKKLSGEAKNESHKQMNGYLNGHLNRPLSPAGRRRNSGSLRGKKSQSLWNLSQSERSNTSSLHAAEDDDGEEVQDAEKVVSEIQGWLFMEGGTLRDVDSLLTRYCELCRKHGIPLDRLFVAGMMMHPHTSACVWKWELGCDFTEDVVPPEAFEPQNFNEEEPFAVLMQGKAMEYRMTKDDEIPAGCDWFKDGGFQDYYALPMYHNGKFKGAMAWSTKCRYHFSDDHQRIFTQSLGALSTVLRLYANDLVIDNAMLRLEEAVQAQTSMLAEANQELELANRKIVDQAQKQLKHFAMMSHEIRTPLNCIVGISNLMLDSCEDDAMKESIEMITSSGDLLLAVVDDVLDYSKLAAGKVETKIAPTKLNVPVNTVETAIRTKAIENRVELRTFYSPDLPEFVVTDARRLQQILYNLLGNAAKFGSTGKYIDFSVVLEPTDRNFLRFSIKDYGRGIAPEEMHNIFEPFRQLASNQPSHGGTGLGLAITRQLVRALGGSVSVQSDYGHWCEFIVCLPCDSGVRRPMGASAVPNTLVQDGSQSESHMDDYDDEDESDDDDAGSTGSMSIESSTEGSSYADMPSTTSFQRLVNEASRRQVNSMTGDTRNHQMNPLAPTAVASLHKLRTNLLSSSSLKSGSTGGSSLASSSGFGSNASSLLGISGLNRNRQQGGSNTSLRNVQFQHFNKSPKQTLGLDGFSGRTGSFGQLGNAIGRKPSGSRSVRRGDRKSGANPHRSASLKSRKRPVMTPRRGSGITGGTISLVGVVDEEGTPRIIPAKKPPTMEPESKKRSVPPTKEEFTKPTMKNSTATASNTAAAKAKAKDATTATSTTTTTTTTTTTTTTTKEKNNSKESLESQMGTIKVLVAEDNKINQKVLQRTLIRVGIKEDIDIVENGKLAVEASDDKVYDIIFMDMQMPIMDGLEATSIITRRAIHPKIVFLTAHALSEYQEKAHEAGGDCFISKPFKLDAIRNIIQKLVLSPQEEEESEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5K9</accession>
    <name>A0AAD2G5K9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5K9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042231062" evidence="1">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="269" mass="29294" checksum="F4F863D01CA42BBD" modified="2024-05-29" version="1">MTSKIEQMILTCVVLLSLSAMISAEILENDSCIIGNDRGQFFSHSPGEIVTLNPPVCGFSACACNPTQENQLLCSFCYDSRLDDCLLNGESKTYPDQNLHCTCSSDSIDFSCMELAPPNKSPTQKPDIQIPAETPCVFEDAFGNNVLLDTSNVKGPCSGTKFPYVCNVERNLLLYPYCQHRTITGATICAKNDEYVVFINEQGDNTRCDCSIDSNTLQPSSDCYPQSDRTLAPSPAVPTQSSDATTIIPRLKSIGNIILVFGILGALWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G618</accession>
    <name>A0AAD2G618_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS20275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G618"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1963685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="47617" checksum="418D35E2FCBA8475" modified="2024-05-29" version="1">MTILADPSGLIVGDAETVGIRYFPGEEDKCPPFRVLYPASFNVRHSSSLGEENEQEGSTTTTRASNQTSRRRVSWFHEHGVAFFWNGYLHVAGIKKGSWLFAFLSTAIGAIASIATFSCSVLGWNGLHFPRGLLSVDAPPAIVIETKKKDKKPLIVFSHGLTGTGEENLLLMSAWAKMGFVVVSVHHTDGSSCRVRIQNAASVAAAAAADGFYKHGPPFANYDATFRPKQILHRTRDIQQALEFVATSPDLAKIRSICNIQEIISAGFSYGAATAVLVAHTIPQRIKGLILLDGWFYIDVSQAAGIEFEFPPQAFLPEDGSDLSTIVPSVFINSEAFESYTKIYQATRRLARQFSGSGSVPRQNETPLSFDNMHVLKGTQHNNFCDVIFWFPTRLLRYLGVIGQGCDPRDRYREIIRISSDFLKTNFHETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6K5</accession>
    <name>A0AAD2G6K5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS20480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6K5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009220">
        <property type="term" value="P:pyrimidine ribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="109"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1964116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="471" mass="52055" checksum="3865E2E324697507" modified="2024-05-29" version="1">MFQQAMKSLRRTMIKGVLAVGAIEVTTHLPTEGRSAEVYHFVCDEMAMPVIRRFINPEDAHHLALAVAQSGLAPTYRPTAQEQKIDWSMPNLWIEDDKSTKDSKSMAPPNCIGLAAGFDKDAAAIRPLFDMGFGFLEIGSVCLKSQPGNPKPRMFRLVPDEGVINRYGFNSQGADAVEANLQAYRSGGVDKTKEDSTSNEKSSLWSVVSKFLQNNGLDKFLPRSSDEQAVQGLLGINLGKNKNSTTPTEDYRTLIQQLGPYADYLVINVSCPNVDMKNLGKSTSAMEELLLACQDERNKVLQNQKGSKKKIPLLVKLSPDLTDGELKDICICLMKIKIDGIIMSNTTSTRPNGLLSSSSIVAERGGLSGKPLKERSTECIRKVYQWTDGSIPIIGVGGIFTGSDVYEKLKAGASMVQIYSGMVYRGPGMVSKLRHELSERMLQDGYRRLDDVIGLDHEDLYWKRKNYKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6T0</accession>
    <name>A0AAD2G6T0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6T0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1964927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="19512" checksum="2A340FE05E3FDBC7" modified="2024-05-29" version="1">MLYRGADRRSKGHCWKIAVACCNVFATGDERRSMWLECFLQLGMSQGADVEARDEKGNTPLHLVCNSFIYFDENARLLLDGGAIVEARNNDGRTPSLYLADRGGAILEAKDSGDNKPLHIVCSRDNVDVVSLLLGEEGADLEAKETNWGCRPLHLAALKSFITPIMLPVYSWTGVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6Y4</accession>
    <name>A0AAD2G6Y4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6Y4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="25563" checksum="2298FD03AE13EE23" modified="2024-05-29" version="1">MPKARISLFGSLTIWGVILCVGTLMTSSIESFAPIPSLTSTSTRTSRTFSTSLRSIFGDDDKEEVKDGVDFQSFNPLNYQAAGNTKQNQQYSIQISLRQVQMKEMTGELLEAVGDEATTNEILARFKDFLLEPLDDPDAVLVSEKKDVHDSILTGGTKLGKHLLSDFLCAYFRRLQDPDSIYTPQMSRAERYDAYRSSMDERIQNSKNGGVRSILQSMRDFVLSFEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G873</accession>
    <name>A0AAD2G873_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS21281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G873"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1965688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="738" mass="83921" checksum="3C525ACD158F99FB" modified="2024-05-29" version="1">MPFTLFGSNGHEKRHKKSHGKKHNKKHNKKPVQQEKRPKSPGLEKRSYVSERHIDSPRLAARKLLVSIMNDCENGNDDDSFDAPPSMECTDAKARNIVVPECAAYKNVSGSKSIDTDDDMKPILLQMGGDSVAGDGSEAPSMLSSRSGGPPKEIFQETLLQEQTNLEDERSPMVVKKRLSQNEKDESRREEFQTLMAKFKPLDDQDEVRESPAEKERRNIYDMEWFAKVETGMKRRYSNDDNGTPTTHDDSFKSDPDTLPDAPLLSESETSAKSYRKVKTSSESFSSLKNEDIYRQQSSKGAIARSYSDLFQAARAAKPVFEEIMKKIFDHICFENADGMIARFADIKDQERAKEKANGLYSRREPGPALSWLYDIVRGSVVFSSPEGPMRCIEAFQLHPDVNVVNVRNKFMSDGGLDGYEVLNLHLQIDTKKGFRHVCEMQIHQLDVDSLDLEQVDKERLDDLLEDRLSLAQLERLSYLFNDQLRQYDWAEVVLRKLLKVQLDKASLGRLGHGSLQVAETSGRLGTLLQEQLDRPSEALEMLEKELEILKKQLGNHHMKVAETSAQIGDILHAQGETERALEYYGKSVEILQLQEDQKQYSWVNGTREDISSLMSQEEEIRESLEMYSKSLDKYKMTVEEGLSNLHETFDEMHKCASDDNSLDQVIQKNNQSIDECQKTLLEYIPHCHHGLGETTKVQGKVDEVFEVYAKSLIQSYQIRKLQEADGPVKVQVVAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8Z8</accession>
    <name>A0AAD2G8Z8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8Z8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042154957" description="Subtilisin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="999" mass="105040" checksum="3A265F7442CB0A6B" modified="2024-05-29" version="1">MRLSTLFLIVLTTAPALSVHGQCMVCPDGPDSSAAGTPACTNLDTRYKNITFAEECAGIQMAFMPSCCPSQLATIAKDNACGWCTNGVSEFDAVVELPFSTESVTCGALMFGILGTQVDPDVCTFYNSIAPICCPNGEEFARCDFCPFGMDHPDVVLPSSDGSSCQDIKRYADLVFEGEMCENSLKPVETVCCPSTTDNFVCDYCSGGLEFPDNMLDDSIQCSELTLFSKLANETQCEDIKISEALCCPSSTTNSLPPVTEGDYCYLCGSAEVEMKRPEYQPFALGDSVMTEDDLMTCAQIEQDMNDDRQPGSSCMNAVGSFTLFFSPSICGCGGFEPPNACDICNGGTVNRAAMAPGQNFTCGEGIDFLKHTSAAFCASAEDVDLDEINAACCIYDDADADDGDGATNNSGAEIYGQCVTCPGGIEFPDATPNNSNGLTCSTIDTAYASVDEASCKQFQYITMPACCPSQIPFIAQGNACGWCPNGVTNLQGQVDLSAFQSDIVSCGEMMTVVASRDDQPGVCDIAQSTAEICCPGDSGGTGFDCEFCTMGVEFPDLVVPEAENLTCFQIEAAAKIANETICSTLVQPIEGECCPNSVIAPTDPPVTAMPAPTDMPVTMPTDFPIPTDPPCVFCPLGIETEEIDLSFLDILGLPIPGGLLGNFTCSDLQLSAALSPSLACDDDIILFENFCCPSTSGGYQCNWCPGDLGMEFPDRQVPLLGLDLPALTCTDILSFIPAVTTKETCSDYQTAESICCPTTVGAVQCDFCSGPGGLEFPDQSIDDSGLTCTDFASFALGAPNEDFCQNIEAAQGLCCPASSGVSLPPVAEGEYCYICGNADVVMTKPDYQPYAFGGAEDPDDLVTCAEIEALINEERGSEESCGSAIASFTFLFSPSICGCAGVEPPNVCGFCEGKSVKRDVVLPEENVTCGDAYDFVQHFTSSIACDGANTEFGEAERICCGDELEQGGGDGGSESAARSSGAGLFFVYASFVVGFVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9H4</accession>
    <name>A0AAD2G9H4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002267">
        <property type="protein sequence ID" value="CAJ1966216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9H4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="108" mass="12434" checksum="82D9E8C2FA5AC4AE" modified="2024-05-29" version="1">MVRGKIHRYLGMTLDFSVKGKLKIRMDDYVKNMLEDFPIKFNKDSKQETPAGNDLLEAGKGKLLNAEYRQIFHTTVARGLYVSKRARLDIHPTITILALRVREPTESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9L9</accession>
    <name>A0AAD2G9L9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS22475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9L9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007378">
        <property type="entry name" value="Tic22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33926">
        <property type="entry name" value="PROTEIN TIC 22, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33926:SF4">
        <property type="entry name" value="PROTEIN TIC 22, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1966889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="269" mass="29501" checksum="CA92F3990EC459E5" modified="2024-05-29" version="1">MMDDEGNGPGTLTSIGILLIMILFVGTGLAPMMGGGDRDLSIADSVVTRQDSPQKLKNYESTQDRLSRATIQEKLSAVPVFYLSEGGNMQTDIFLSYQEANDVAAGKNGVSVKVTSLDQVMYPLILQRGRMRMAPPPPEIEKAEAQLSENPGKKYRLIPSKPSVEQANEYKLNLLENDVPLFVADRLAFAGSKGPQLPLFVDKSDCMLSYQRLRSGKSSLPEQPNIRTTTLLDELYSMEKGTRPGVSQLAFYATAEDVNQAASLFDTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA14</accession>
    <name>A0AAD2GA14_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="506" mass="56460" checksum="1989428BB3A75892" modified="2024-05-29" version="1">MQIEHLKETISKQQDEIHQTEKEVQQAHQETQKYQAQAKTSQNKHEALAMQLHNLQVVVQETKKSSQLLLDQQDELTHMARSMEEQYFQTQATNMQQQRQHSHLQQEHQALLQDKEKLQNRVKHLQNDLKAKERQIQQHWQQSVKTLEQKQVWNVQRIEALEDELQESKTLTLQALTTTQKSEATSQQLQTELATLQSTLDECQQEYKSQQEQLQAQLDESRQKCQSKEHSNQKLVAQMKQVQHQGQDFRLELQAMEQILKEQHKRRNKGGSTTSIISPATNSNTTTNQQQVLCAEKCRACQLPYALGLPQHYATISSPTNHHPNAAKTNTKTITPTTAALTKAATFRLVQSTSATTTTTTSPLYVCLHCVQAIAQPILASTSSKRKNGGKSSSRGRKRRSAPGEKIDCMKKAVPVGSGIGNSDKQAVGPIPGGDDGTNNSRKKHCFMTEAAESMVSSTTTGTGTDAAKVATNGQEASLHLSPKTRLTSAVARMVGPPSSNQVISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAS1</accession>
    <name>A0AAD2GAS1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAS1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="229" mass="25811" checksum="CA401B66B7C9C7FF" modified="2024-05-29" version="1">MMLNMDYWNDSIKLNNLGVESLQQGQLDRAAECFRKASELNAEASYDSPLEGYGVYSSQWITLAHMPLHQMAVGSISATPPCVLAIGDKVPKDSCVHDSERQSNVFVTRLDWIIEFNLATTLQLYSTHAALSGCCSLLLRESFQLYGEVAQDLLEWNNYSATMDLAMFLMTIYSHQASICAQWGERKLALLYRRRLDRIRHCCAHTTQAESQRQQITLALCESQCAPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDI8</accession>
    <name>A0AAD2GDI8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="611" mass="68712" checksum="ABCB722CE4E6B755" modified="2024-05-29" version="1">MMCLLNNTNNIIAKLALTLIVMLLAVAPIILQQLVHRAQIVIAPVRDVIHNEIATLSTTIFTTIAAITDAIQTIVNRAFASEGDAFTIINNINNNNTFLAVPINETYLQLILRARPRHWILRSPQKIIFWTPRHLIPTSACATIIAALSIIDAIQTVANKALKSYSTAVFNNNKFLALPVSETFLQLIPRAPRHLVIRASREIIVWTPARRLIRTSFRATISTAFLQTIIDAIQAMINTVLESDSIALFNNKKFLALPLSETFLQLVPRAPRHLVLRASREIIVWTPARNLIRPADPAMVIVRIIELTQELVNTTTIGAAKPFALTSLPTPVPQGWVQHYFSLGAIMPLVPPPTFCSNRNFVSSLVNIMIFDHHEDNKQNEAAANPIATTESTDSPIVRSSSDMLANIAIAADKEENNLDDDEDDVGHVDATAATTATVPVVPSITTKEPESFVVSSKLPFWMSKRFIARAADKKVKGRRRGQFKQCLGAQKKAKIQQQRQDAKQQERMDGGQEDMEIDHEEDEMKMEIDHERSTTTDTCCSITASNFKRRRGEFKERVVAQNKAGRRKIDQQLRNAKRQERLRQKRRMDEMMKIDYDWMELDGDTIMNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDX1</accession>
    <name>A0AAD2GDX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS24107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002458">
        <property type="protein sequence ID" value="CAJ1970084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000:SF642">
        <property type="entry name" value="INACTIVE LEUCINE-RICH REPEAT RECEPTOR KINASE XIAO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="97"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1970084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="75651" checksum="6BFAE5FD5D153387" modified="2024-05-29" version="1">MEHDTSSGSQSDTFKDEGSIGEDAKLPPSHEENQKEIAPEISDEQQNSEEHRIKRVAGTSEAKDAKDDMNKSDLPVEERNYADAWNLSLEHANATYQSSTSFTSSMMDSERSNQDRKSSVSERLHQQLQRQSLLDESKQNQLLASDGERIANSIIAEKEEMAGLHQSPSQEDSQPQNAKEGESEALDLEQPSALPLAGPTVSSSASTKAPAPPVLNRLNHLRPSTPGAVAMVGQQTQANVPEDDRTIQVGIDDDQPQEKEAHSPLVDAVLVPDHDDAMEAPTSPQSVAATTAVPMDESDLPRWDFSSRRVKGIICVLVVIIVVLAAGLSLLFLQNNDDDVPIETDSPTTTATISLVPTASPTSRMAALQALLSQYVDDVTPWENTESTQHRALDWLANEDTWRTAFPESPDADQIMVERYAMSVLYFSLGGPNWNESESFVDLDRRVCDWQVEDCDSIGQCEIYGVLCSGGQLVSGLILDEVEAIGTIPSEIGLLSSLSSFLVENNAITGTLPGELFLLPELESVSIVDCDLTGTLPSEILQAPSLSSLHLLGNALNGTMDNAANSGIEELDLGHNEFTGVIPESFGDLTSAFYLSLEYNNLSGPLPEKLSNMLQLYYLSVHNNVGLTGTVPSTYNKLSLTNLFLDGTNVTEVESVFCGTGLLDYEEFFADCRGTSPKVLCRCCTHCCDENGCIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGW8</accession>
    <name>A0AAD2JGW8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS11598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842:SF0">
        <property type="entry name" value="ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842">
        <property type="entry name" value="PROTEASE S51 ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1948401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="512" mass="56348" checksum="734CBE07B36EAE97" modified="2024-05-29" version="1">MSRPLSPVLSAPTSGPAQSYFFFLLVATFSCCVNRCHALLPPAPATESSIQSSVISNNVVASFSRLSHYNGKILESRTNFRRRTTIRYATEKLAEVTKTSSDTSAPSSSSEAPKRRQLARGLLLSSFSDGLVPNPQALDFWMDSLVESMWNQYLQGLQEKVESSAKASPCCGPTDVDSVNQLLDAISDESSSSFTDEATKKTGQWKVKFQKLLEMQQHQQEQEQSGESLSLSSSPLELRFLYIPTAMYALRKDSTNSPGKQRQRARADGKKRRTQIVQLIQDQFANAYHEMNDCSDDDIKEQMKSSPVKALAVSFDLDDGSLKQPEGSKNTSKFPSTGMDALKDWKPNLIYVQGGNTFWLYHCMEKGGWRDALVDAVTVGDDNNNQAPAVYCGTSAGAILAGSLMETATWKGWDDPTVDPDRPNYEDWKGIAGLDLAGENVSVFPHMGEQWQDIVDGKMAQLNADTNDDGDHDSSDFSLPAPEVYCLRDDQAVCVNGSGSVLTRTLLEYAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH00</accession>
    <name>A0AAD2JH00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS12302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041781576" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="36"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="212"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="445"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1949849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="535" mass="60766" checksum="F3B5941333864A98" modified="2024-05-29" version="1">MAMMMLSIFTVISTLIVLQTARAAEGAPRVCNAAVKHLHLAVGQNPSREMTISFASTWTDIDSGNDVEKPVGGVFVGLSPDDLKFIPQQEFPFRYHVLMEHKTKPNTTYWSPFQHHITINDLSPNTMYYYVAVVGKSGEEIESMAGVKRKYSKTRQEEKDSLFGREWKRGVNGTVRRNLTPSPYNGTAMPCFDNRNVRSFKTAPEQHIDEVTFAIVGDLGQFQHSIQTLKHMTSNRDTIDAVILVGDISYANGHHENWDTFFDFLDDSLIFHQIPLQVATGNHDIEKQENGSDIFQAYEARFRMPRVKPARLEAFDVPGKLNLDAPPYPLPYNWGNAFYSFTYGPALHVILSAYSSMEPGSEQYHWLEEKLDDVDRQTTPWLLVSLHTPLYSSFAAHKHDPQIFAGREHLEPLFVKYQVNIVFTGHIHAYQRTANVAMGRVDTKGPIHITVGAGGRQCDAPFKSLEVEDWLLARDASFYGYGLLSVLNRTHAEWSWVPLSASDKHDYNYVKDDKDTKLPPLRKDYALISNQFFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHG3</accession>
    <name>A0AAD2JHG3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHG3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="453" mass="49823" checksum="ADD04DFEEC0ADABA" modified="2024-05-29" version="1">MTTSEPYWTTAFQPTGNRWAENCNGGSVLSVKKDAADGRLEWVVGSQTSDTQFLGLHSNGKVIRFSSTDESDTTFNLNEDEIVFTRPLVATGDPLMPIFSPPSGSIYSNAIPVTEGVLYVDSSNTLRFDTENTTSTIEGITDPLLDAHITYSSTNRMWAVYTYMTDQRYDHGILGDRAEGYHLTILKQVGDGTSLLQVVNDIVLQDDDFIVFEDLAPVWTDVDQDGIDDLLTTIATSRQGAAMRVYLLNADGTVKGQVQSHYIGKGNRWLHKIAHAPTGPNGEWEILDCRTPHIGGIVRYYQYDGTSKLVEVARLSSQSYTSHKIGSRNIDQALVADLNGDGIPELIIQNQRRTKIVGLQRTSSGIEEVWSVPLDSAIHSNFAVSCAEIGSAQLVFGTTDDQLYTVSFTTKNGTMGMNGTLDLDGPVAACRSCSMQWSGILSLFIVIYHLWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHW9</accession>
    <name>A0AAD2JHW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHW9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="157"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="56981" checksum="883CB293A7D0A2BC" modified="2024-05-29" version="1">MQGSSETGALAALKPYLESVFSIEAEKPFPNCRVGIRVTKSNRWKVFYVSQIREDSIFVNTKLKTGDVLVTINGKPCPDTLPNVLGMLASMTGPVKLTAAATKSSFDIEYDDEEKGEEKGIATSFSTSSQSTHVNFAGEVTSRRLTTFEVTKKKKSDKLGFTVHVSRFKNPDGSNQLIVTRGQRDGSFPDLKSGSILRSVNGKPATDYKKTVKQLRSSRSLNIAVEEPLRPSLLGQDQRSIMFGKRHIKIETPPKGVIIIWFLIAVELLFDLVTTSFAFKAFFEESRTCCGEKIDSGAIPLATALPFAFLVVAELGFLLRAMRLTMWPPTVSEEELDPNRSCISKLFFGSNPGIVIFVINFLTVINPFFGFIIAWMLIYQSDEKEAYFVVGMESIAVILHFISVHYEGQARTMVGKLIHSLVIIPFLATGVLLSWFLQVKGICYNSEVNLFWFEGCEVCPTGVPPENGLCPIIETLNGTNTTVGYEQYYLWELEQTNYCDGEFRMCFFPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHX5</accession>
    <name>A0AAD2JHX5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001787">
        <property type="protein sequence ID" value="CAJ1951562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHX5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="109"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="262" mass="29873" checksum="8C748335A4B13B80" modified="2024-05-29" version="1">MRESAVFIVPDEDPSYTLHYTKILPRNCPRTARRAKKPGRNRRQVTIKFGVKVPMSVSQALEFDQENGNNKWQEAMKKEIAQLVALNFFTFHASDYIPDADSQEAKLTMIFEVKQDGRHKGRLVCNGHKIDPRGISTRSTVVKGISVRLLDVIAHRDNLKIIQGDVGNAFITADCLEKIHARAGREFGEAKEGCIVTLNKALYGLRTSSRAYRETFAKFLRNLGFVATCYDRDVWMRLRETNDGYDYLCTHVDDFKIVAKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ89</accession>
    <name>A0AAD2JJ89_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001877">
        <property type="protein sequence ID" value="CAJ1955051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ89"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="858" mass="97171" checksum="B6DBF3B4E05F268D" modified="2024-05-29" version="1">MMLEEGCKDEPAFLNGWFTDATKASFKAMKTEVESTSGRVQKAKVRDQWLANALTNCGNQPMLVVDNCSVDAWMAFLQTFRTSKGKLLGKTSLGVKCSALYHLFRCHDAMGMPGQFKQELSVKKKGLYRLIANAAQNEGGHDSDGKLPMSYELYVKCCQWLLEKGDDRSIFCHCFLVLTWNLMCRANNTVTILFEHMQWQADHLELLFCQQKNDTTGEKQRFPRRLYANPQQPEVCPIFALALYLGLRDGRSEMNGKLFQGNSQYKHFMDGLSNVLKEHESELLYMGYVSYTEIGSHSIRKGATKWLSGQPGGPSSISICIRGGWSLGGVKDVYMTYEAEGDAFVGRMLSLLPLLKSEFAVSAPEFTDLSTEELDRHITRVFPGLAEHNQMKPILHLVERLKQKARVIYPWEDNAADVRSLSGIPPHVCQTVYIERLVKFAEDFKSGWQQKLKDTMNDLFNDRNVANASINGSTWYLPEEYEWPQGTAQSLWNAWSTEDTVNKIPPLKFLKGADFGFMAGKVKRTPRRKFNDIKTLCKYIETQAANKGLETANLTIEEADDIFLKIATEENCLKLPDGKRSVRWATTLKKVRESRKLARQPQETNEANPTEPSVNQDEEIEENEEARRNPETTRNSEMTTTPTVVTAETRQIRRKVYRRRNRPAAASREEEKSKRTSHRNGNSRTISTRDCNQKTSRTRSNDRHNNPARKRRRTRNATIYNTPNDDDSEAFAAAFASIEGPTSVDAVNRQRDREEGKDGEEGLNAVMRREAAQVRAARGEPQEEQPVALTDGTALHLNLSANGFPIGPCGIRGGCDHPHQELRPIHRCVHCQTIVHLLCAGEPTDQEQVTCGCRDDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJG1</accession>
    <name>A0AAD2JJG1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="694" mass="78170" checksum="F99B122B20465075" modified="2024-05-29" version="1">MSAFASGRAALRLSRNRASTSHWQSLYQSTHTVATRGLIASHNIRPYGALCQPPPSWSSPASRIFSTYDGSSMTPAQLQQLVLKHSLQDDPMEAHTILNQLFMMDSKEVTPEIQTAVMDSWIVYQSKCQQQLNESISSGSNESNLSEVHRNVHEMGKAAEHASQILESMDSPSRHHIVAVLKALANVSEASHTTSVFKGDFVRGIPQRAQHFWQIHENLPIEASNQLLRAWAYSKEYLRGTMAEQIFQQIEHPNGESYKNIIRAWCWSKERRCAFTATGHLMRMMRLLETGKSDMEPSLDDYHVLFHAWTTAEDKNAPSKACSVIQIISGAHKRGHTELAPDETCYRDTLTTISRRVNVPEVGELADNMLKEMKEAMFIPDSECYSAAIQAWNHVATARESEDREGAVQRALDLLQEMTKAYHRTTTVTIRPTVKDYNNVLEALTISKNTKATRHAETLLTALEEADTSAVDGLKPNAESYKFTFDVWKNSKSPNKVPRSLNILRRMTDRAEFSTDADQTYVPAFSSFIDVCANCGSTENSRKTMTLVLRIFDEMRSNGLQPDSSTYAALLEACNNLIQDGQERQKVLKRVFVKACDDGYVNQTVLEQFKKSASTYSFANVVISHSREVEGMKVVPESWTRNIQGFQVKTKGGKQVLPLSIGGQFTFTKAAAEYKMRKLRQRHNQRLLQGGRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK19</accession>
    <name>A0AAD2JK19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="319" mass="35807" checksum="5F35666D5865AED2" modified="2024-05-29" version="1">MRGFGSSSIPKGELEAYSRQSLVSDVDALRKHYCGDDGSFAMLVGHDWGGVVVWATLEAFGHGPTKIAKSAVLINAPHPRIFSNYIYTPKQALKSWYIFCFQLYWFPEFFLHRTQSLYYSSHEVEYQHLVNGLGLSISNDKASCTAETNVNEEESTCSVSKDAKMPYTTIEVERNLAIFKEALTDRDRIHAMLSYYRAMTAGFWSEPRVELSLVNQAIRWLHNSNGNGNEGSDEASEQPMDSSTLSSRGVSIPTMILWGKKDKFLGEELASAPDGLLENYQGTKFFDDAGHWVHWEKPLETAEALIQFANTHNKGQPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKY0</accession>
    <name>A0AAD2JKY0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS18421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1960004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKY0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1960004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="301" mass="33365" checksum="253260B0F683A616" modified="2024-05-29" version="1">MMKTNNRPCFPQRLFLLLKLVEEKGLDHVVSWVNDGSAFKVHDLKEFQDVLLPKYFSTKKYASFTRQLCAYGFSCLRTGRQTGIYSHPGFHRSDPAGSFQIRRESAKKTAKSHVSRPSVETPMLTKHQGIMKAGVPNVQAGIPQSTAKTFEFPAVFGSNGRYTSADHTNQLSHLHNLLCAPKTATSISQPTVNQTAQAPAIPHARKISQYSLPVLDSSDDSQSDNGGYRTGVSMDDLEPIPVFNWENALLPQKREFSASLNGFSSMFSNNNNKSNYVEPTDEELLAGMYEPQSISTVSTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL25</accession>
    <name>A0AAD2JL25_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002016">
        <property type="protein sequence ID" value="CAJ1959748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL25"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="314" mass="35479" checksum="8A7F03240B2257D7" modified="2024-05-29" version="1" fragment="single">MEVNPSEEIWSLRILAMRISLQNPFSFFGIDEFEGKPDDNQFFSGEMSNPRLRLEHPLVGFWLICSELFDYPWINEFLVEYYDDPPSAIVDAIKQTRSGKSINNAPNRESVKEPDPPRIQKIYDPMYSIDEPGTDVQRESTSSEGDQVQNPNRFAPLQSDDDWFEGSGIQDFDEVEVVAVKKNAPKAPELLDEDTEDDDIDDRENIVDDAMEEDEDDERVTTAGANPHDEAMVDNTPPLTSSKLKAKQDSAGTGTFMEPSESTPSRWARRNYAHAFASASRLRPRSRPSKTIFIPAYVNWGEALGATLLPCSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLU6</accession>
    <name>A0AAD2JLU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS19809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1962693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="62442" checksum="BA82ABC75D68CA6F" modified="2024-05-29" version="1">MKKKPKCDIWIVGLAFSAIYFALLLTQVIHHDPTAMALEHSPQEDLVMPRIKSSSTEPKESRSIHGTNHLPLQEEESELRMLHNALNETLTSSPTATTTKTTTRTSTSTTTTTTLTLTTLSPTVIAIETRERQDHNYSETNALRNQTRIPLSDSASSATSSPNPLPTLEYNGTNSFGACLMWMDDYERLIEWIAYHYHVLPMRHLVIYRDPKSDKDPTKILERWKPYLEITYWTDIHQLSFIPQARSILSQLNGVSRFYKLQGIVATLHGNIRSVDLPNMLIWARFPGLFYRNCLNHLKQNKWTWTFVGDTDEFLVLNAKVLPAAPEMMEQSGIILKTLKAAQSGNEIMKMQNTTVKLINSQKQNIRWGNKATLCLCLMRQQFSGFESPQEAVTKDVPAVFDPFRFQTMRFRYHRRKTIIGKCIIDASRVSVNVYTRFSQHMLIRECGSAWGESQDLMHVNHYLGTWDYFDRPNDVRGGKDRYETFMKKNLEVNKTITGKLGDTPRKWLASFLQTFGEEKASVLLEGVGFPYNNKTALPTMIVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP10</accession>
    <name>A0AAD2JP10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002380">
        <property type="protein sequence ID" value="CAJ1968353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP10"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="388"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="503" mass="57123" checksum="F68465F75EE5A270" modified="2024-05-29" version="1">MMYLNTPTESPNSSPFEFERIRKEVDSIIAQCMNDTTHEERQKSYLEVHGVTNGFDETPAAVQDALEGMKMEIQKITKNRDALTLAESMDEEYVNDPSLHLKFLRGEKFNVKKAAQKFVRHFELKLELFGKSKLVKDIEQEDLGEDDMEALHLGYVQWLPLRDISGRTVTVYFTGKTASKATLLSKLKVFFYLRMIAMEDEVFQKKGMVFISQTGLESEVMEDVDQPAEEFGVKETARLCEALPECTQSVHVCIPNVSSIGAIVAFGVYRFAMAAYNKLVAIRTRIHIGSSQEECFSKLQAFGIPVAVIPKSPADNDYHINLMQRRKRLEHKRRQRKRRQGDGGIRFSSQNDQESEQVEDSDDEGFTVSFDPLDERCNWICAGPAPSDVILGRGRKANNHPGNIRLRTMVDDLIGVYKNTSKREKTEIAQRVVVSIQTNGRFLKENEMIGWVEVPDKVARIKVSHAFRDSYRVKRKQGGDNGQSMVGQKHQLEMPAGKPTRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPL7</accession>
    <name>A0AAD2JPL7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002453">
        <property type="protein sequence ID" value="CAJ1970046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPL7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="529" mass="58706" checksum="119C06A8C22243E5" modified="2024-05-29" version="1">MGRSLFVDETLVGKTSIPLDQFIVNEQLAAISENTLSTASGYEFCDAPTGSESFYKYITSFNSKVDALSHAHTDVSAKPSVPTGAAQPIDHASIIKEAILASKTTATKDVATEAQERVLLSWRILFGHFITHPDGSVETDKDLASHINEDEEACMWQHVIDLTGVAVHILHDLQTVFQVIASEAKDFTLHAQAQPLGTIQRAKLFSGARAQTQLLLDKIDEGLRNCRRPNYPRMSALSALISSTAAPDASPSGKRSSESPSSKQDTVASPAKKPKRSNEESTTRGMLICTSTRRPPMPDQKWKVNGVEKTACVNFLFQNFPCTNTCCTLLHLHKRVFQSRPVSEQESFKTWVQSTLNVKWGLLGRNHIPVINFLLSHGWLLLPHQVAAASVSTLTQQVNYYASRPTPKSHCIDPQDECALQDYPPTRTIFDELDPADMLVAERFRHILEQGAMVTPTFTRLEQSHFLRDLTSRTAVESPNGKDSNDRCFKTESFSLQERLLGHNDRRSLGQSFLRSLTSSSVTQEPRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU96</accession>
    <name>A0AAD2PU96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001738">
        <property type="protein sequence ID" value="CAJ1948051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17374" checksum="6DCA7A92DE333941" modified="2024-05-29" version="1">MKWMIDASFAVHPDFKSHTGGTLSFGGGAAQVMSKKQKLNSRSSTEAELIAVDNVVTMILWTKLFMEWQGYPIEKNILYQDNKSAILLEENGRKSAGKRSQAINIRYFFITDQVEKGNVKIEYCPTDDMIADFMTKPLQGEKFCKFRDLIHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUN9</accession>
    <name>A0AAD2PUN9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001791">
        <property type="protein sequence ID" value="CAJ1951625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUN9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="148" mass="16555" checksum="A9F9A283D201DE58" modified="2024-05-29" version="1">MGIGRAALARELMRHFNFKIAIALEPAWPQNPGTAGQKWMPSKGPKAWYIWVAASDVDRVARALFAWLRPETKKCHMPFGARTQFVYDWGAITKERLGDLAQPGGQWNGIIGKLINTHDTTSQTCTSLAPLFPIQGMLTKVVIQKYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC03</accession>
    <name>A0AAD2CC03_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000023">
        <property type="protein sequence ID" value="CAJ1927625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="554"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1927625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1371" mass="152792" checksum="28C7FF5A12013E58" modified="2024-05-29" version="1" fragment="single">QLAEQGYMRYNIPGRLSTLGFDVARQQGVITKSQAVRFDRIHGMEDPVEILEGTLHIDIHAKHVRDVDDGLSVIGYLDDWNESQAQLQTALQTIEIITDEKNSLNRDLQSVRDELEAMKAAHETAATMTELSKTVRPVPMLTVDVPTGPPGQTRVSTTTLLSPLGHGSATPATAHETDGEDGEDQPNASSPMDTGRDGFGDNHLVRAQGSARLAFQNINTTPDESDDLKQAQLNHWIRSECVDFLLLAELNKFWPVITPTNQWRQRASTMARKGEGFHSAVAYNTHQPRAAHSTTQFGGCSTSAFNEVSHQVRSSGDDSLGRWAWIRLQGQTRGVGQRDLVVLSAYRPNPPNDGHQTVWFQHKAHFSRTNRDAEPREAFIKDLSTAINKWRDDGCSIILGIDANDDLSSYSPKSFRFRMSEVGLVEAIQSKHPGSHQATYQRNQPTKSTHVPRRLVMHNKRVVQRYVQLAEQGYMRYNIPGRLSTLGFDVARQQGVITKSQAVRFDRIHGMEDPVEILEGTLHIDIHAKHVRDVDDGLSVIGYLDDWNESQAQLQTALQTIEIITDEKNSLNRDLQSVRDELEAMKAAHETAATMTELSKTVRPVPMLTVDVPTGPPGQTRVSTTTLLSPLGHGSATPATAHETDGEDGEDQPNASSPMDTGRDGFGDNHLVRAQGSARLAFQNINTTPDESDDLKQAQLNHWIRSECVDFLLLAELNKFWPVITPTNQWRQRASTMARKGEGFHSAVAYNTHQPRAAHSTTQFGGCSTSAFNEVSHQVRSSGDDSLGRWAWIRLQGQTRGVGQRDLVVLSAYRPNPPNDGHQTVWFQHKAHFSRTNRDAEPREAFIKDLSTAINKWRDDGCSIILGIDANDDLSSYSPKSFRFRMSEVGLVEAIQSKHPGSHQATYQRNQPTKSTHVPRRLVMHNKRVVQRYVQLAEQGYMRYNIPGRLSTLGFDVARQQGVITKSQAVRFDRIHGMEDPVEILEGTLHIDIHAKHVRDVDDGLSVIGYLDDWNESQAQLQTALQTIEIITDEKNSLNRDLQSVRDELEAMKAAHETAATMTELSKTVRPVPMLTVDVPTGPPGQTRVSTTTLLSPLGHGSATPATAHETDGEDGEDQPNASSPMDTGRDGFGDNHLVRAQGSARLAFQNINTTPDESDDLKQAQLNHWIRSECVDFLLLAELNKFWPVITPTNQWRQRASTMARKGEGFHSAVAYNTHQPRAAHSTTQFGGCSTSAFNEVSHQVRSSGDDSLGRWAWIRLQGQTRGVGQRDLVVLSAYRPNPPNDGHQTVWFQHKAHFSRTNRDAEPREAFIKDLSTAINKWRDDGCSIILGIDANDDLSSYSPKSFRFRMSEVGLVEAIQSKHPYIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC92</accession>
    <name>A0AAD2CC92_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS85</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1892014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CC92"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="HUEL-CATION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414:SF9">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="133"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1892014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="524" mass="57729" checksum="57DA12299D900450" modified="2024-05-29" version="1">MAAFSTSNPLGNPLGNPLGQNNPLTTDTSAVALKMNSSGLLRGKSHQYHDYSRHHVFNKKLNEALNRATRIVLDQRRQLSDGDEKTGKDDTSWMKPPRMRVPNYGPDADKAVKNLQKARKDRARAKTAANVRRALIGNAVICAAKFGAWLTSGSSAMMSEFVHSVVDCGNQSLLLMGLRDSKNTADRLHPYGYGKSIYFWALVSALGTFFLGAGVSMSHAVGELMEPSLSDISNEVWAVLALSLAIDGYVLSETFKDVQETKPNHVSMWNHISNLRDPATMAVLLEDGAACLGILIAIAGIGTAHYTGMPVFDGIAGVGVSCLLGGMGLALVRVNHKFLLGHGIDREMSDTIEQIIRSRRSIDNVNHIQSQWTGPETFSFKAEVDFDGTYLAAQLMPRYRGEFEKASENIDQELEVLLCWYAEDVMRAVEREVRHIEAMIRQKYPGAEYIELEPMSTDADRFAIDDSFEEKLLNVEREDVKRLIRVLYAPTESSSKGDPSTLGYGTVEGKGDDAVVIEPPKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCN4</accession>
    <name>A0AAD2CCN4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1925916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCN4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1925916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="363" mass="40782" checksum="38717782F6BF3A88" modified="2024-05-29" version="1">MLQQRLATARKVLALLTCLSYLLICADALLLPRFSSVIDRNEFLSIVIVSTGQLIPSSWFVEKQLQHDDSSSVIIPLRFLPVGGSWAIKILVANNDERDDKYYAVVDTGSPFLTVPSSLASVTERTTYPMTKEQYGQDISEMDWKKIPYVTILTNSSVIDTENLVVGMEETQQPNQEAGSAFAGLVNIDDNRPTFLEQLTRERISAFTISFARNYLQLSQRSLIDKRNPAAFPLVDLRPYGPDLYHYAVDSPRLVGARYRIDRMRVLRLINGGASQQARQQRCCPRRNFSLYSIPESTTFGIDKFGSILGVFILSTSMVSGRTKPSTYCCIGLYILDPVREFDCGHGISDSKDHSSSTRCFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDN1</accession>
    <name>A0AAD2CDN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS1999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1930606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="99311" checksum="C2C92B7BF7FE987C" modified="2024-05-29" version="1">MTSVSSTKRHPNSGNGVGLRGGRGGMDLQGMGPEVKARLFLFVACLWPLWVMALYGASARGVDVAGPNAAMKTSRMMKLRNVLDRVDIMGYGPTHPRVAVIIVGDTRESLLQSVESIYRTTDMNRLFLICAVLDGHGNDSTLLAELDKIEKGSVPHWHGLRPEIHIGKSHEEHSKKIHVLFNPHKRGVAASRTDAADFISLLQHKHESAGLKSPQEDLILLLLEGGTQLTDNEWLPAVTTSLIVPPPLIHTETNDDATENIAMKLANAVALRSQDHGERMAADEHLQLVQEPVPAAHMQQSSGQTYLTPVWNGGGLALRLDTFLNFPAQDASLRDAWAANLDVTMNLWLCGDGIDVVQEALITQPLAPTKINADLAARFAAVWMDDKSAQKFLQWFSPSTKSLDWETKLTHARNSPTFPKKVQSRCRSFGWYVEEINTVLSKILTEEPPKRDEGEADTSNESSSEDAQAVARKIFGGAKAGRQNGRQEEEHKAPPAQEESSSSKDEDGRKKPTFPLRKINLEIVQKAKPIDIKFVDVSGGHKEHPHMGANDEDGKIGYIHNEAILHRNPPTFHFDSDKKEHMACAPRDNNWKMMTKRVKVESEYDQKMENSGVKRDKIFCLVYTTEESHGKIPNIRETWASKCDGFMVGSTKTNSSLGTVDILHEGKEEYENIWQKVRSMWSYIYDNYYEKYDWFHIGGDDLFMIVENFRYYLESEEIRTAGNGGMYLPFGNETMQTPLLLGRRFAYMGDMNNIFDSGGSGYTMNKAALKALVVNGFPNYFPHMHTFSEDTMVARVFRKMGVYPYDTKDDNGGERYMPFMPGHHWSYHLPKDPSKDWYAKYSIDIKEGPEHSSPQSIAFHYVKGDDMKRLYALAYGLCSDEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF99</accession>
    <name>A0AAD2CF99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS2726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000213">
        <property type="protein sequence ID" value="CAJ1932183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042176681" description="SAP domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1932183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="413" mass="46401" checksum="07ACFC86637F011C" modified="2024-05-29" version="1">MSSLSSLLLLLRVALLIHLSGAWTTTTTTTSNIIRRPSTMIPTRSKKTQLQSGIGIAKDYTWREEAFEIEVTVQVPPETKAKDVGFKARANSIELTLTKKVDGGDDDNKNETTTEKVILLDPTRALRGRIVIDGTYWVISDSIEDEVKNSAAAETDDDDDDDKESSAKQPGRQVTVTIEKQIQKAKDDFDVVDYDWNGVYREEEKDEVSYRKYDEPEEMDVREYAQSLGVDIDNINMSMVDKSMFSSGLNTTSAKSNMESMMDAGLMKEVTQQGDGSEWTMGKDGERVPFNSMLKDKDKDDSLYSAEDEEGGRENDAIPFLDTDSPWHDAPDATAAEEAAKDDKKKNKALEEKKKQLEKKRQKEAIDPISTLTVARLREILRSRGLKVSGNKKELQDRLRAEVQSLVKMDTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFB6</accession>
    <name>A0AAD2CFB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000236">
        <property type="protein sequence ID" value="CAJ1933021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="69"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="18355" checksum="10132499EE947AF2" modified="2024-05-29" version="1">MQIPTTPSHLLLPTSFDHDQNNMEAQQQHNFVFSSFMDLLLIPKKLPREDQAEDTVEEEENKAGIRLFQEKQWQAQFQKLVQFKLQHGHCCVPHSYSRDPTLARWVKRQRYQYKKKMSYKVGDTTTSRSTTQSTFSTRRIQELEAIGFVWHPPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFS2</accession>
    <name>A0AAD2CFS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1930981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFS2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF958">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WNK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="131"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="459" mass="53252" checksum="888E8C5E42157541" modified="2024-05-29" version="1">MMMIRHISKPTTIIFKHPFDSNTSPLVYPPQLLYLQDDEAPASDYENSNIIDLLQDDETHDRQRDNMDHVKDSRETQSSDVDDDHVSAYYAFDDDAIKGGQTETEEPCRRISEHRNDFQNCNNFHEQHLLEGGIKFLGEGAFREVFGLSHPFREPNEQFVLKELRFDEDINDENSEFIRMDAAVAERLSASPRTFDIYGFCGVGILSEYFFHGDIEEVAYEDEGEVSEDLREIEEFEVQTNLTGREKVVLALEMAEGIALLHGNAGGVIVHDDIQLSQFLLNKDKTMLKINDFNRAEYMLYDESKETYCKYHNGGGNGNWRAPEEYKNEGLNEKIDVWSLGNNMYTLLTGLDPFPWLHSKEMQVRESNHRFFRSLYRWLNICVYPPVLGYCSHWCIDPRFWARSKEEGRLAEIIKQCFEYNPDLRPSVFDIVEQLREVVTESLGDENVTRAQVLQGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFV2</accession>
    <name>A0AAD2CFV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L9, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS2921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFV2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="entry name" value="Ribosomal protein L9, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_bL9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_bL9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="Ribosomal protein L9 C-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041948949" description="50S ribosomal protein L9, chloroplastic" evidence="7">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal protein L9" evidence="8">
        <location>
            <begin position="103"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL9 C-terminal" evidence="9">
        <location>
            <begin position="163"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1932607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="259" mass="27818" checksum="414411E3FB865ED3" modified="2024-05-29" version="1">MKTILYLVGIIISALALPASAQYTSWHATFIPAASPVATRRNANAEALSFARSQMISGGYGLYPPTTTSTTMTTSKNTAAAASTSTQLFAKKKKVAPAAAKKIQVKMLKHVAGTGQAGEVVLVTPAFFNNKLRPQQAARMITDEEVAEETAEKQMKEDADRTKANELKETLDELELKLVRTAGPDGQLFGGVGPKVVMSELQSEIADDFLNNKWVKVTEVMDENGKKMRGDIKTVGEFGARINLLSGISAKIGIKVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH27</accession>
    <name>A0AAD2CH27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1917770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1917770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="148" mass="16009" checksum="D1F9D8D49EF7B28A" modified="2024-05-29" version="1">MAEKSEKTVLQKLMAVNSKPTAETFPELPDALVWLRAGLAVAYACWLGMSTMATEGAGLLMGINLITFVPFIFCSTYLGANTDSFGNQILTAGTFNALALLLLIWIWFFTANHESEENAIIAALKATAPIVAEEIFEPEAASEAQVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHG2</accession>
    <name>A0AAD2CHG2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS1036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHG2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000453">
        <property type="entry name" value="Leucine-rich receptor-like protein kinase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053038">
        <property type="entry name" value="RLP_Defense"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48064">
        <property type="entry name" value="OS01G0750400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48064:SF6">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="319"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1923541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="483" mass="52889" checksum="FD5862E49BA48C8A" modified="2024-05-29" version="1">MTQLDHETPFDAVAVDPASRPNLDDQLSTETDHWETNKNKCCYLFHHQEGSNHWKKAAAVAAILLVTVLGIAYAKAFSLTSNNSDDSSLSRMEYRAKMESMAEMISDPLTLLDPFSAQSRALDWLVDTDTLSIDIDYDHSSDNNNNNNNNNFKQRYALMVFFFATNGNGWTMVETWDELTGTSECSFSGIDCDSKMRVIALSMSARRLSGTIPEEVGVLSYLETLILGRNDLQGSIPSSIFTGCQRLVRFDVGFNRLSSTLSTEIGTLVNLQVLLVSSTSISGPLPESLKNLSQLLSVGFVRTNLEGPIFDFVQRWPNIRALLLDGSNVNLTIPTEIGKLTNMQSLRLHALGTHGGSIPSEIGNLEKLEHLVIEGTTYTGSIPSQIGKLSNLTYIRISGGLITGTLPTEIASLTSLERLDLMDNNLDGDISADIGNLEQLTEFSIAGNNFEGRLPGTFCSVQAIFYDCTLTCDCCACTCFACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJF0</accession>
    <name>A0AAD2CJF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000513">
        <property type="protein sequence ID" value="CAJ1935827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJF0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="45009" checksum="869E142AFFC51DAE" modified="2024-05-29" version="1">MSEQLLQGDLSPILPDLISSPSPVASFPSWDDDSVSTSCFSEIDAHDSDPPDPTPSVLINQHGTVSIYNATTTIATSIAEFAQDHLFLSKTSANMEPAFPVIWDSGASVCVTPHQRDFVGTLHSPPNSSTKGIGGPIEVTGCGHVAWTFKTTTNTFRTLILPAILVPLANQRLLGTSSLLHCHSKETISLSSDSMLLSGTTSDGASTRPIAVDISPTNNLPTGTAYRVIDSPQPTPEAHADDVTVAINNLHSSQGPAPTSSRTDRNSFMMSSIAKVRCHNINLDDGDKEWLKWHHRLGHHSFAIVRFLMRTGTLAKSQRMRTLHTHISKQVEPPKCAACCYAKAKLMLASRMLPALFAPTLFIPVKRYPSIILFHLFLAEPTLATGKFTSLRCSADLLSSSTMRQDISSFNIRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK36</accession>
    <name>A0AAD2CK36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS4511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="8">
        <location>
            <begin position="137"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1935174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="226" mass="24243" checksum="91D3067DC2F8BC98" modified="2024-05-29" version="1">MTTTPPKKMINVNGIMRLNPEYNKWKKMQDDSGGGGGQVAPSAPPEAEMAAADASGVPMVAAAYIHDSDQMQYPAATTGAAPGYSAPSPVVVAHSNQHEPMSTVPAPNNNGTQGYSSPVNHGYSSTVAQQTPTHTPNQATGQRPPQYLGKFGSRPFDITCPNCHRQGLTRTDVVISTGTIVAIILLLFFFWPLFWLPLVMTDCKQVDHYCPHCRVKVGEKPSSCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK51</accession>
    <name>A0AAD2CK51_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS5231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK51"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="148"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1936517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="432" mass="48454" checksum="19D158B868EA307C" modified="2024-05-29" version="1">MCNPNSTIAAFRRRARAQQLLELQTGAVNAQYLMANSLNESALANQARETVPTRTVQTDNNSTMPTGKAEYTGPSYGIPTTFSALQSYQLARSAIPTKPKPKRRRKPQKPGKTAKQNDRHFVVHDYHDHANDTEEYDQADPTDRRGGVSISFPIKLHAILDQVEADGLSHIISWQPHGRCFVIHKPKEFADHVMPGYFRQTKLTSFQRQLNLYGFNRITRGDDSGGYYHELFLRGKTFLCNRMVRTKVKGTRFKAASSPEREPNFYLMPPVKSPMHVTPQTSDCDNSDDGYPNQMYAREAIAPTPFASSPQQEQDVWRQSYQEQLPQAAATIVENSSNYSPLATMSRSLIHPGLAAARLPSPAKYQMPPMLPNQNSLDDNEISELLLDSFSQDSVNNSVQQAVDFSNIFDPIGDNALSSDAELSRVLCRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKU9</accession>
    <name>A0AAD2CKU9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000402">
        <property type="protein sequence ID" value="CAJ1934857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1934857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="384" mass="42093" checksum="9E1A363C66CC2AD3" modified="2024-05-29" version="1">MLETFELFYESASVGDVLGVNRYLDSGEIDINLRHPAMDGRRTALHVACNNDHLQVAKVLVNRGADISKEDDNGDTPLHLACEIASFRIVRFLSSRGAAMEKKNRRYGLTPLGIACSSCDSELIELLLDQGADINTKDNDGNTALHVLWNSNLVRLFLDRGADVHATNDGQQTPLHCACQKSFLAISRLLLDHGANKETKNEDGYTPLHSACREGHSAIVKLLLERHANTEATDEEGITPLCTACESGHSDVAKILLDGGANLEAMDGGNQTPIFYACYGGDAAVVKVLLDQGANAGVKDNDDTTPLHIACQHGYSEAVILLLDRGVNVEAKRKDKMTALHLSCYNNHFQVVWLLLSRFPWLVLGRPNVVEAQKKKKTKKQRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL79</accession>
    <name>A0AAD2CL79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1938082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL79"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1938082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="956" mass="105946" checksum="598D3047578286D2" modified="2024-05-29" version="1">MTTIEVIFQPDVHSDSCYTILGCGRSGSPEELRKAYRDLSRKYHPDRYRANKDTNHAFQRVYVAYSLICKSPQEGEDVKFERQAMRQAMRQVHLEDARRAYESAFGDFKEKYYSKGAIVALPYPFELRERLERGKCFREAFTLQIGCLQFNLFRSFLIKKELGVLFLLSEIICVWGSLSLAVWNFLLEEFPEVIDEIPYVRDSGIEEIPHISIIGGLAVLIGSFVQHFWYGFTRHPILVDDGYGNWLWDGESSSSGELGEILRICSQYYHSDVHKRSQVLTCLLCLPFLLVDQIPAILLSIPVYLFFLCQNCGTRNESTQTHLAYQFAKSIGGLLVVVGTYLAWVLGGNYAKLACAGVLYVNQHLYSAILFRKSVFGFLQSVIFQGFFAVSIVRTPRKQTIAEGKGNAGATDIEQGVSREKKESAPNAVNNKPEAPAKAATRAPAPAVKRNQVSPQKVIEEEVIDIVPVASESPRKKPASAGMEQADPDDFGATFDGFYFRPSPSTTKSQGSRPSTSTKSQGSLAPTTTASGNTESIGVDHRGKKYIKPVPGWYQKGEVITDTQQAAKEAQLAPKSKGFDNINIFQCGADTTLMDEEEKYFDPALSLSGDKETATGFTSTKGSTKGSTKASTVVTSFTSKMDEKQSPEAEAPDLVNLARSAKRRIEAEFYARIYGTPAGTGISSPVSPERKGVTRLAPQPYGDDEQDEFIVPRTIEMKTPPKEKMASKSASPISPSTASLADNTSDNGSGKNGENTRISSDESTSRMDDSGFIPMYKSPDRQGGNAYPAKQKRSMGNRADNRPKSPEGEIDNLLGPFVPFVKSATTRSNNYSVGASQTTRMQSNKERETQGEESSGFVLQHHPGKGLSGYRHEEEEKIRSEKSDPGGRKFEEVKPIRSRTTGQIPDLVVGYEQPSADESEITMDKRQFRKKQDTGPPTFWDYWTSPTNSTLTRSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMN8</accession>
    <name>A0AAD2CMN8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000069">
        <property type="protein sequence ID" value="CAJ1929167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMN8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="115"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1929167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="544" mass="62653" checksum="109D0E7D688D5474" modified="2024-05-29" version="1">MEDGGERQPESQQVPNTSSTSHPAETILKIMAAELSNATKKCIEGEIFCFEAMFPAYSGEAEQDPLKIFKATSDPDTMYMHEAMREKDAGEFQKAMKKEWEDQLKNENFSIIHWTSLPEGATIFQTVWQMKQKRDIRTREVKKYKARLNFDGSKMKYGRDYNQTYAPVASWNSIRTLLIVSAMLGWKTKQIDYVLAFPQAPVERELYMKLPAGFKVVDGNSNEYILKLHQNIYGGKAASRVWYQYLTKVLVDKLEFKKSNYDECVFYKGNVMKPDGSIHLTQPHLIDQILKDLNMQEDTATRPIPAASSKLLSKHSDSPEFDGSFHYRSVIGKLNYLEKGSRPDIAYIVHQCARFSTCPKKEHGKAVRWLARYLKGIKDKGLILRPDRTKGLEVYVNADFAGNWDPKEYEDCNTARSRHGYFINFAGCPILWKSQLQTEIALSSTESEYTGISYSLREAIPIMNLFKEMMIKYEIPIESPIAEVHYRVFEDNTGTLEIARVHKFQPRTKHLDCRLHHFRSYIGNGITIHKIDAKEQPADVLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPN4</accession>
    <name>A0AAD2CPN4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000546">
        <property type="protein sequence ID" value="CAJ1936113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPN4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="17242" checksum="5827E7C8B01CDC99" modified="2024-05-29" version="1">MNRSGGSIVKKHLNSRTVNNMTVILGDGATNAEDKLGHDFKQRLQKTLSHEKTDRQDQERLYCNQILRMTKYFQQKCFRYFEVGVCKNTSAEMNDLAMYFYDKYEYHLIYAGLNVDDVLKFLMDQMRTTAGNLRTKADMQQFQDAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPR1</accession>
    <name>A0AAD2CPR1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="216" mass="24727" checksum="2717DE06BE84B9E4" modified="2024-05-29" version="1">MMATDTEVKFPGSQIYNTVLNGCKLHHDQEGRPSYTFCLIGDHKSVKGNPSIVWLVKKLTGMSSVPKSHDEFSFEESETIAKTQIRIIPESXXXXXXXXXXXIMMKLQMTVQFATHLQFPERFLGILPMPKEKVEQKGSRSMRKVVERDAVDALKAVREAWLSRTVETTSSRTNEDNDDADAHDTLTRQQQDNVPQKVPVRQRIRSFRQRFAQARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQK8</accession>
    <name>A0AAD2CQK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000786">
        <property type="protein sequence ID" value="CAJ1939394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="176" mass="19622" checksum="F707F6D7E06DD5DB" modified="2024-05-29" version="1">MKKRKETIVSTKNCIGSTKAIVLGQPKPPGQSITYNHYTINTAVLAPTTESPEIKQAILQQSVNSIKQTKTTMEHRVDFLMERYTSVCPDICSRFNTTTSKLFDVTSDVYEFTSLHVINNMGQAIATGFPPPVYHNEDGIANVLVMRKMIAAGYRITMDTDADNAFIVHCDGNRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSZ3</accession>
    <name>A0AAD2CSZ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001369">
        <property type="protein sequence ID" value="CAJ1945348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSZ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="17497" checksum="3D2C7A8A3D3FE906" modified="2024-05-29" version="1">MQGFWDCMSLWKLLLKGKKGCRVSSRKVCRLMKKTALPQAWRKSAVDLEDCLKQERSLYKQAKHTYAAQWRKDFLTVQTKDAKKHQWKSRKARDRFFWLQRMKQREEARRRRRAQSKGSPGAFRLFKLKNTYQMVLQVSGPSLTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTE1</accession>
    <name>A0AAD2CTE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS8014</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010304">
        <property type="term" value="P:PSII associated light-harvesting complex II catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF113">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042194227" description="AAA+ ATPase domain-containing protein" evidence="16">
        <location>
            <begin position="20"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="226"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1942572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="672" mass="72017" checksum="AA2E61048ECA8431" modified="2024-05-29" version="1">MKFSITALMGFQLAQQAIAFAPNTPLAKQFVQGPTSSSRAMAVDMPPASDVPVIEKSTYGPTGVRYSDFLKLVDGDKIEKVTFSSDGSELLGVDVDGTRIKIEALPNDPELLTQLTSHKVDVTVLPQQESGGLGDLAQSLIFPAALFAGLFFLSRNAGGAGGMGGGMGGPGNPMGFGKSKAEIQMVPDTGVTFDEVAGCDGAKLELAEVVDFLKQPEAYTKNGCKIPRGVILDGPPGTGKTLLAKAVAGEAGVPFISISGSEFVEMFVGVGASRVRDIFGQAKKNAPCIIFIDEIDAVGRQRGAGYAGGNDEREQTVNQILVEMDGFDGNPGVITIAATNRVDILDSALLRPGRFDRKVTVDLPDFKGRERILSVHARGKPLEPDVDLEAISRRTPGFSGAQLENLMNEAAISAARKAKTTIGWEEIDGAVDRIMVGLEKKGGNQVAKQKELVAYHEAGHAIVGALVPDYDQVQKISIIPRSNGAGGLTFFAPQESRLESGMYSKQYLESQLAVALGGRLAEEIIYGEDMVTTGASNDIQQVANIAKRMVKEWGMSDKIGRVALSEPSGGGPFMGMNMLRRQTMWGNKILGTVEEEVERLVNNSYLIAKEILISNKDLLEHLTQTLIEQEVVSAEEFQMMLVEFKSKTVDYAIIGNERNREQLPFQGLPASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUY5</accession>
    <name>A0AAD2CUY5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUY5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1942516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="180" mass="21260" checksum="6C4A28EECDE0D1DD" modified="2024-05-29" version="1">MANENHEEEGESAPLPKNITVTNENLVTKHPLVHRGLGLTDNFGVELAIVVGSAIFFRRLWILHGIHFIVLRRTLRLAIAWIDYFFEAGIYEEIKRTAVYIFRFYLNHTEKALSGDSMRLFFAASWLQTYNAWGYHIWFAILRRQYKHVNKLELNEQEDKLQTTEMLVEKRRQQQGQQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CW63</accession>
    <name>A0AAD2CW63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CW63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042190940" description="Lipoprotein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="18642" checksum="B7579AD77EA5B927" modified="2024-05-29" version="1">MKSASLLFILATTANAFSAMDRRQWFGQAAGAAAILATGAPDAQAAMKTGAASAFTGDYDDPNHPGCLRQVKVIGAPLRADGTRSKYPVVEVTGYDGKGNGAMCTDRPTRPDLWKIQGKLLSETDAVIDFSPKGGPQNLKASYDNGIVFPDGNKWTKVTGGTDDRRPEDMSTLKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWI5</accession>
    <name>A0AAD2CWI5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001547">
        <property type="protein sequence ID" value="CAJ1945857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="44" mass="4592" checksum="030346F9E55845C6" modified="2024-05-29" version="1" fragment="single">HESSSDENSGEEELEAKAEEENYAEISVANDRTAGGGNQDGPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC22</accession>
    <name>A0AAD2FC22_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxisomal membrane protein MPV17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1910410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF116">
        <property type="entry name" value="MPV17-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1910410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19202" checksum="CC6F839EE1B198E5" modified="2024-05-29" version="1">MMLRQAARAGAQSGTIMTLADMGTQLFVEGETKDEYSVERTLRWTVVGLTLHGPYFLAGFSMLDKQFGAATSLRIVAMKTATAQIVVFPPYLVALFGAMGYMEGHPDIAEKIHTQVPKAFTAGCVFWPIANVVNFTFVPPALRVPYLACSAGVWNSYLSWTNSKSNEIGRQEKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE81</accession>
    <name>A0AAD2FE81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15839</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4171</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000396">
        <property type="protein sequence ID" value="CAJ1934834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="341"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1934834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1955617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="505" mass="55938" checksum="DF398F04B22B3705" modified="2024-05-29" version="1">MYRPTQRRTLNQVKPNSAFLNHGQQQQMPPPPPPPQQFHHRRSTGSSLGKNNGSTNSLQYNQQQPPNGSGQPPSIIHRPPPRSPGDMSFSSAGTSTSTSNLYGAGAASHTIMQPSHPAVASSLASASTSAAAAAYPSATSSSSSSYPQHNPQNHYAEVRRKPANAYSQSRNGGGISCGFFLLWTCLLAGGGWLYFNYFLLPSLVKDVTREEVEHTKHHWMTKYHSLQLSHEALEKSHVELKQTAEAAIVAAEKAQKLNGSTNSEQVQSLSRDLEETTNMLMQERTWAGEWKAKAIGLEEHANFVKQQIQEFSRRRLIQKYGYRQLAVELELNFGENDSAWITVELAPMDEMPHSVFTFLEQVEMGLYDDGGYAFHHNGEHIIMGAPVYNQLTPPDMDPAQRFADSGVASVLFQEYSYNYPHGAYTVGFAGRPGGPNFYFNTRDNSELHGPGGYAEDGSADPCFGRVTRGTDIIDRMHALTGTNFEPGDWKEMNPYVAVRWIKILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFF3</accession>
    <name>A0AAD2FFF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="603" mass="69071" checksum="BDE1818DB3AABFCE" modified="2024-05-29" version="1">MKADKIHAQSPSDNGEQDGKELLSPGDSLENEKVDETPYLIGEHNGKPQNSDEGGSQTQPLDSTSSTIAEPINSKTYDDYSWRRLPLEIQEAAIRLGYTKEMWNEDLEPESSNKDWEELDPEEQEAAKALGYDKTTWNSEDEEKTPKDYDPLSWKELPKQIQEAYGVLGYDNELWNRDRSHATLEKDWDELTEEEQKAATTIGYTAELWNEDSGEKDRDVESSQIERAPLVEEPANAKKYRDCSWDELPSEARDAAELLGYTKAGWNENKEPDVTNEYWEELKSEHKEAAEILGYNETLWNFGDKEVSPGDYDDMFWNQLPKKIQQAYQLLGYNDDLWDRDESPAAIDKDWDDLTEEERNGAMVVGYTETTWDDDDSDDEDDVAGHQNELIGIRGEVAEFLKGSSYILLDCMSMSAFFGVIESIFLIGKLFLSDHAVNAIKILFGLSIMQFSGQLRKWLGAEKQTKKARSRKKREETTLFRSFLNVFSWWTTFAGVSHFFNAFKKDYLYKQAEEWFQNFYELAEEAFEAELTSGTATGNITCSYVENFDFNQTIGGYIIGKACALSDSKWESIGHFYCCLVFIASALPLWFLFGDNFLKGCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFM0</accession>
    <name>A0AAD2FFM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1917869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="4">
        <location>
            <begin position="99"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1917869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="202" mass="22291" checksum="E936506F3F6EE880" modified="2024-05-29" version="1">MTSSAIRIGSIVSRRAAAHTQNQKFLGFSPVASERLFSSAAVAQKPRRRITEKKDPIEVVGSAKAASFYSETLGPSLTHVVFFFPFVRVNCEYYFNRKTERAAERIKGILSGDNAAGALGIRLGVKRRGCNGLSYTLNYAFEQPEKDVEMEAHGIKVYIEPMALFSVVGTTMDWEETELASEFTFHNPNSKGECGCGESFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG65</accession>
    <name>A0AAD2FG65_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000697">
        <property type="protein sequence ID" value="CAJ1938270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG65"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="206" mass="23265" checksum="A23313ED6F8EE4C6" modified="2024-05-29" version="1">MEIENAKFLTCIDTTVCYRSCIPVQNLKTDPVFEALDKIFRRYNKAGFQVKTIKCDRAFIPLTDDMLDNMGATIDPTAAGDHEPTAERNNRTLKERVRVALARLPYKVVPKVITECLGRQAAELLNVFPQKDSISSNFKPQQLIDNVNINYKSDMVAELGQYFHAIGTDSNNSMEPRSIEAIYIEPTKGQHTGHQVLNLNTKKMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG84</accession>
    <name>A0AAD2FG84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS5076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666:SF1">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="5">
        <location>
            <begin position="200"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1936207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="452" mass="50927" checksum="C01A052A5A764E6A" modified="2024-05-29" version="1">MSKVSTNQKSFLNRKEVDKSLASNIDDVTRAVGGFICDEFDCVHNNFTGKLYTGPSAILFTGRIFFFDWCQRISWMDVVQVKKKKRSVDIVVKEPKGTTFTFDNFFDPDRVWSSLVDLHSDSILDTPPKPATPRELSRSLRRNNSDPFSLSQAAFTFEKETNRESEDLQVLSTVSTEESIGNSSVTDDLSWISLLNDATSYSQVAVKDLELKCSLDTFFDLFISDSAKLSIPKYMQGSGEENVYSSSWKENDSLMTRVVEYSHPVNAPMAPPLAKARKEQSYRKYGRDGVALETKTIVEDVPMTDCFYVVDQIRVAAMGDKVFVTMVYDIRFVKSTMFKGIITRTTKADMEKSLQGLAAFMSKSLHHDGDTVLSLTKSSPPQQESQDYRSVSPASLQSFLSSTVLFLLFVFQLYIIWTLVCIQHDIAKLVANSLGHTALQDHILLESARVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHC1</accession>
    <name>A0AAD2FHC1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000724">
        <property type="protein sequence ID" value="CAJ1938503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHC1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="107"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="227" mass="26441" checksum="D3754DB3B495B8C7" modified="2024-05-29" version="1">MALDRNVLDIYNDDDADDAFIMDAKYEATSGAEVADKQQHLTEDQRKLLAQALKNTDEIFDGQLGHYKHEKVHLELIENAQPVFSKAYSVPKQHEPAFLKELKHLQEIGVLERTGPSEWASPTFIIPKKDGRVRWISDLRQLNKNIKRKVYPLPLIDDIVARRSGYKYFTKLDLTMMYYSFELDEPSKKLCTINTQYGLYQYNRMAMGLKPAPDFAQYYIEKTLRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHF9</accession>
    <name>A0AAD2FHF9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000768">
        <property type="protein sequence ID" value="CAJ1938784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="237" mass="26620" checksum="42083935F9382E06" modified="2024-05-29" version="1">MNLRRHCQLNVGLISKPDIRLQEFLTAQTKDAKKKKWKSEKAHNRFLWLQQMKEQEEARRRCCAQQKGSTGGLQAIQIEETLQDGTMRQRTITNCALVEEGCMQENAAQYDQTRAPHMTPPMAEPLYTAFSGAKAKSNSIALLKGHYSFPALLDPSTAASFPIANFTRIIHPYTLRLRPPITCTSGPGIQRTGVLNPMGFTTATSRQLPSHHLLPTVMLCFAIFPWQLDSSTHIGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI28</accession>
    <name>A0AAD2FI28_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI28"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040192">
        <property type="entry name" value="CUEDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13467">
        <property type="entry name" value="CUE DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13467:SF3">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29350" checksum="B5A37EFBFB28BEA7" modified="2024-05-29" version="1">MSITYEDALSTLEAMFGAPWTRETLDTVLRHEKGHMENTCERILNHGDKDPQILVDRLQSGEPDPQQAIDEALALQLSAQEQGGGRGGGSRPAPATSGKKKAQAAAGQKGRGVPTSLPDDFLRVPGFKIPANAGASAAATPMDDESLARMLQDELFSEELARNPDFAHLARGRGGGRSAPAQRRSNATAPPPNPFEGVNVMEKLSEMGDNTRRRLQIMARNFELKLNANKAPVGGGGGTGIPENTSSAAERRGLLDDDDDMEQIEFEMHKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIX8</accession>
    <name>A0AAD2FIX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS8197</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIX8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="10">
        <location>
            <begin position="198"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="430"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="808"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="851"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1942940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="903" mass="103260" checksum="7BB33066BAC5A79C" modified="2024-05-29" version="1">MPSNKQSLYELIARYPQLLHHEENVSRSPFAVSTWMVYLDDIDSLITDRNDDYAELLLVRDLQARRAVQILPKSYKLWKVHWEFCTYHKDKVFSHSTLMNMWEQALQTLHKFPRVWMEYLAYAHASNKVHPTTLRRLANRCLEALPVTQHGKIWPILLEYYQTPGEYIPKESKLAILRRYIQFNPNATKEVAEFFFETLGNWGEAALLYVELLNQPSFSPVERKDLWMDLAKICSRHPVSQVGLDFEAMTRAVLKTPKHYNLQELEGVVWNQLADSWIRQGEFQLARSVYEEAIECVSKVRDFTILLDAYLQFEEGLLEATVEAQAENEEDEEGENADGDDWDLLLQRSTGESSKSTTTMADLELALARAEDLTARRPILLNRVLLRQNPSDVGEWLKRGRLFMENEQIPQAAAALEEALQVVHARRAVGGKPSQIVLDLVNIYDHGMNELTKARDLLDRVCVQFSYEFKDVDDLAECFAAWVELELRHETWDDALDVIRRSVVVPPKAPKMARGLAKSLRLWDLLLDLEESLGTMQSTKDAYSKAIENRVATPMHILNFGSFLTEHKYFEESFSAYERGVELFEFPGVKVVWKAYLDAFLKRYGGDKVERTRDLFQRCLEASPPEESVEFFLMNGSFEEEHGLARRALGVYKQMCENVPPSEKFEAYQLFIAKTIKYMGQTASRDVYQSAIQNLDDASSAKLCLDFAKMETSLQEIDRARAILTYGAQMADPRRNDEFWTGWNDFEVSHGNEETFREMLRIKRSVEASFSTVNYNAAEMSGTDGKPETLSNEEAMRLIAEREGVELEADQTKETVPGFVGAKRSAQDASLDDMEERVAKLRKATGAEPTTNDDEDEIDLDDLEDDGEEEDEAPPSKSIQDISTKLVPAAVFGGLAELSSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKD8</accession>
    <name>A0AAD2FKD8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000626">
        <property type="protein sequence ID" value="CAJ1937304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="18353" checksum="1BFCD7100C9F58EF" modified="2024-05-29" version="1" fragment="single">EFEDGKVESFYANQIIEGIMMNVDDEEPAFAWWVPYTLRKRDRVLKAVKRRAVKRQKPEKFGIEVPGPGPRGVARAYELDAQNGTSHWNDALIKEVKTILPALKILKEDEDVPVGYQLIELMTVFDVKMDLTRKARICARGDQTDPPMSVTYASVVTRESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLA3</accession>
    <name>A0AAD2FLA3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000876">
        <property type="protein sequence ID" value="CAJ1939929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLA3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="343" mass="38175" checksum="534843F4AD53DE52" modified="2024-05-29" version="1" fragment="single">MLKIHMDVIKNPGVNLYQGKDQPNKGKGNQMIGMQLSQQGFSGAQVRQGFDATPAQTPQVVKTGYYDTSNVFHDAIKGKDENGNNVYLIPCPTGTTNVELQSDWHYASKSEDLPDLATEADRGMQFIQSRRIERDPLGLLDHVIMDSGCTNTTICNGELMHGLRQAEKELDMHTNVGSRVLDEERFLGRFPPPVYFNEDGIANVLAMREMIAAGYRITMDTDFDNAYVVHCDGDRQMRFVNRKGVYVLEQLGADVKPGAKETSVMYRCQLSNVNKQPHFELSSKQNGYAGLGMTAKMATVQKNKEGFTPRQVKAAMEARSAMHILNAPSTKSLKYAIRSGLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM22</accession>
    <name>A0AAD2FM22_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001202">
        <property type="protein sequence ID" value="CAJ1944106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="615" mass="70489" checksum="67853F1D1A07C892" modified="2024-05-29" version="1">MIMEYRNQLGMDDGFEFKEEVINSLPDNKPVVQHVRPYLDCVYELLTNKVILGPNSCNINLHHPIVSALDEMCHGSNSHKTHIDCPAKLLHMLQKGGQMRAVESFEYQFRNGTKITLDDKSFASKKKGIKKGLENLNFIGHQMGDFLSRQSDRNKLRTKFKNSLFSSAKKCGHEHARVILSILLTLMTDRGRQICLEERTMEEDFLDNFVYLFEIVLVMEQWLKSPSFPADEVLDGTRLSKALGVYVENIGAICQRKGMGARLIKNHLMLHLPHCIMRWGPPSGWDGSNLERSHKRQAKRPAQLIQRRQDCFIAQLSARYTEMRLMQYATQFCGLCKSLWATNTGRGRQSTKPMACTGSRFTIGLDTTNYRPGVKWTKDPGRQVHIQTVIDTAFDHIVSNLPLNNSKSARTVDGFTEYKKEIRGESVIFRAHPSFRSKSRQQRDVWYDWALFDLEDQGYGSCFIPGQVLMFLHVPHLQREVTVNGMRVRPNKPHAIVRLFKEKPRSDFQEVKTHSETGEENEYSLLVEFGDTQDELSIIPCDYIAEPTIVVQNIPMLQPQMPLNPKQRRAREKMDGIIKPLGEGYFVVSPQSTWSSCFSHLIQSYPSTLGFNSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNF5</accession>
    <name>A0AAD2FNF5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="190" mass="21618" checksum="EED982DB16A2132B" modified="2024-05-29" version="1">MSTAVATPMQPPMISAETPHQVPSALSDTISRKVHFPRNMKTVVSVLSRRDYSNSELRECFYTPDDRHRIECERERLVRRFNKEPNKKHLHSSLRGLENSTREGSVQSEKRVWAVVDSVLNEQDDQLELREFDCYRIASASQSNSTESTLLALRAAIGDQLAAFSIYRDWASDNRAILNASTKGDRSCKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNK9</accession>
    <name>A0AAD2FNK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNK9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="85" mass="9889" checksum="DBE6A6F565CDCE8E" modified="2024-05-29" version="1">MLKCDIHSYSNDHLEFVKRYQVTSRATSRNLQVQHEFGPPFFRYYKVGLVGRWYCSGFTLTGLSFFQFLNTEYGSSSMGVALDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPB7</accession>
    <name>A0AAD2FPB7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="268" mass="29819" checksum="20C58BEF552635FA" modified="2024-05-29" version="1">MNHVPTLIRSNNSRRRTSLVSEITFDDDDFLSGEISYGSTGSKCDGSKCDHKWSAGTQPCHAVLESRRIFILTSMPHSTSLAMPERKCSTNRLSDRPVEDANNVTLKPLRSKHQEENPTDKFWRSKRLLLSQLPGALAPGSKDRMPNAKWDLGVTGSGLEVKESLSSGCSSDGRQSCPNRKFFSKVRTSFSRRISACGPSVELRKPIRRRSKDRDLEETSDLARNMIPTPIMPIFPLPGRSSFVLSKKHSIASPHKGEGACHLMPPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ90</accession>
    <name>A0AAD2FQ90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46873">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46873:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="86"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="277" mass="31455" checksum="BB4DD4C0B19BF017" modified="2024-05-29" version="1">MSLSSLSKNGHVKSLWDELVTSHSVRSNNLRNKAWGQSKFSLGKSQSFSSLSSSGLMGTKPFPIQPPEQLVKGELILTFPLFYNRQIRVQLRPEWSPGSVDYFHRLVQHKCASCSLYRLARQHSDDPGEGVILGVMQNLKSVPLNTQRGICPEGSHRHYHDPDANNEEKDENKENEEEKRNPYDDDNPRENCEDCECQGPILQRGMVAWVGGAPGGPEFFINLYEDAVKYEGSRHAVFGEVVDYESFDLLQEIMEENTALGDSRVLHDELHFYIDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR45</accession>
    <name>A0AAD2FR45_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS12465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR45"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00596">
        <property type="entry name" value="Peptidase_M14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF138">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041965330" description="Peptidase M14 domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="7">
        <location>
            <begin position="27"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="623"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1950186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="766" mass="83129" checksum="1E2F58B17C459CB4" modified="2024-05-29" version="1">MRFGASFRLLAWTLIWFQLQSTVESKSYQLYSSSEIHAMLDKWKVKYPDLVRLTTAQEAYGLPTAGSAYDCPFYEGNGCPNAILTIQDYQTHPVGSASSNALPEVLWSGSVHGNERVGPTVVMETALLLLEAATCESFLHEESLSESKTNTTTTTTTTTTTTTTYCGAPLAESGIGDIQRRWLARLVSTRRIVIVPTANAIGYDRNRRTEDGIDPNRDFPYDLLDPTLCMRTIAGRTLNEVFREHLFQMALTFHGGIEVVAYEWGAPSWYGFLSPDDLAQNQIAAAYSKYGGSWPGGSGPYKYGTMNDMVYYVRGGMEDWAYAASWDKDRVRSCQPTTFNGYPLEKTVYNNSTLRVFNMLIETSASKNPIFNLGRPDDLLNQDNVDSFGSGHIARNIRLSLLSADLVEPYVSIVQVNGATLPHDIVPLPSKSENNCGTTTTVAMNATNNTWDNNNNNKLEISFSVGGALTIDQVQLWFANKNDIVSTKPLVNDDCQAQPTLAALQFFQRATIVGPSSGSGQFSSSGPIPASILTDGPLFVGTIDIPNTVVGATNNEWIVMASAKVDQDWNIVPAEAGPDYAQPQSHMANVRTDPNWKHGSEGKVVQGRLDWFSRPLTVVVEMADDNNDGGSTSVPTTSPTMTLSTAPSVTPRLRPVSSDQPSARQSFEPSFHPSPKPSMSPTDRIVTDAPTLASLSSSQVPTRPGDDKSSDPTNGLPLMIPINDDNDGSGTTKPPAGTIDGDSSGAMVFVYSSIIIFISLVGAFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS32</accession>
    <name>A0AAD2FS32_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001782">
        <property type="protein sequence ID" value="CAJ1951479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS32"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042045728" description="Glycosyltransferase 2-like domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59193" checksum="6290D9561D955CAF" modified="2024-05-29" version="1">MTKLRSAILSLWLLNHIVLGSCAIDDSPTSRQLDDENSASSRRMSSLGSKMTTPMDPLIRRLNYPENQPHICLAFLSCCGRTDLLNATIAGAIRHMEEDEPYFLRFEIAWVDNGSGKEATSSISNSYQIENALILPSNSGLAYGMNLLINNLCKAPYILLLEEDWLYLDEVVAKQTEERKRSVATSIALLESMEKNEISAFDGRRVSGVFLREETYTSFLQWPHENLWETAHSINIEHELKRMGAEEPSCDKGSSAESNMVADIDYRIYCSDPSLQKSHIWGSYTNGAGLYKRSSLKHIGRMYGEPGDAFHDRYTEGNYAYRAGLKFCHASIRLTKDVSCDSISNVDCTGAFHHIGGGRGTRPMTAHGSVCEDFGWNFYRTPMYSRYHKFVEASTGTAVQMCSREELKQLQDRKFRDKDSESYRRQVKESNAEVFQREQKQRDNMRREARLVLQYVDAGRSDALRTQVSWMAGKSEESIRIMATRMIKLADSPHPLTGFWDSHGRIVSNQDTEQHERTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTB1</accession>
    <name>A0AAD2FTB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="711" mass="78340" checksum="DFDC456BF3A0CEFD" modified="2024-05-29" version="1">MNGPWKEEDSAFVDSFFLPGGILDPEDEEEIGILSTLPTGQPIPSNPWGNEKAPSTPSSAASYLHAVKQIEIESAASPNMFGERTVGEAEVRMNSPLRSIVRPPPGYDGYVNGLAPNSQHFPNNVSRMGSNHSNVLPTSHMNQASPVHCDGLSHLQNGFLINMNRTCSPNQSNMRYQLSQQGSIPAGQHLPPVDSYSTRGSSLSVPSLAIEVNPKQRNVQCVQSDQSTSATLKSNEEASTSKQNVQNPRIETSVQEIRLKLENEGSKEEVPERNSITSTTVDTGDSIDASSHMIPSCDSKDEVSEHAPQHIVSGVLSHEQNSVGEYSESQSTIDDHSTKDTAVLNKSSSLLEIDDEMSNVDGKTEGRRHSAATCLGHHTSKVAQGAATSSSSNVTQSPQIRYSMSLLQGILRPFSLVFRMVTLLLLDLPRTGANTIASFFATVYYWILSTARRVRVEVVPVTKIIAHSISDNAKRSGASAKGGALLLVRNLSLVPSFVRMMTKASMVQVMEEPSSGFCYLVLYLLPSWCNSLAENFDVPHWSAHFIITIAVYLVSHPVKPGILHRGEFPLAEVIEALFRNGNHCDQAFIDKDERRAAARKRNERICSKCLRVLRYCLPIFCLIDGFSYDGATMIGDSGASRLTTAFMMSLVRRNLAFSPIGWVSWAIQVLVATYLDVWVLRDTMVLLLGLSSFRLIRYFDQKRLKKKRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTW0</accession>
    <name>A0AAD2FTW0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTW0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042152936" evidence="2">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="158" mass="17192" checksum="2C6959E1D5F3E7CF" modified="2024-05-29" version="1">MKFATLLIAAIALFGADAFTPQSQKTNPAVELKKAAASTFAALAIGSSVLGSPFVADAVEPFAFSSTNVVAEKVVRQGLYQDYEVDVVQSVDDASSTFKSAKETKTKKGKYTAILAILVVGSFIVPMAQYFWYVRDDDSSEKFFAEDVPEPPKKKKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV14</accession>
    <name>A0AAD2FV14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF1">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="408"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="738" mass="81864" checksum="1CE3547C100DF3C7" modified="2024-05-29" version="1">MLGLSAESIMDQASTKDQPQSPWDVMWEYILDDFESDDDDDNTVPTVSTRGTIETAEENVMSMTLLKDQWMKAAKEISDFAQTHVIEERDESGSSIYPWRRHQRKLDVREKNESRKVKWSGFGIKSKMAKKQDQQLTAESILDKASMAAVAISTGVKKVKWEEVGGHMINIFDVVQPRHVLSGGQSSSDSSCGDSESKGYSVNSAEDDSISHHDARVDKSAKRASGRHHHRDGYDDPESFLNGSKSMENCFKKPAVRQVEHKTTTQDTNHPKSGTSVVRIPISSPLEEDAGHGKDSSGTGRKDGDDGPSQLTRKFACFAKIENNELDAIHQLDDDMGFFFPAARMVSDLEGQVPISLQMSAENGVMGIPSDHFLGTKGPQSLYSYEYEGRVHMDISYTKFGDDPHECIALRKFEFMPTLKPEDGNRVLLQVEASTISIRDCKIRQGKLKIEEYGSSPVTPGVDVVGKVIGVSQSTSSSFALYPGQSVLSLVQVGGNSRYISVDPERLVKVSEGMDPAQVVCLCDTYLSAFQSLHYGQIAFSRYAAKSLEGKTVLIIGSIASTFGKAVMELAVDGNAAIVFATAKRKYWRMLLGLGIIPLPDDSTEWLNRVEGTVDLALIVGMEEPSRVAAFHERALRENGRLIICGCDEPKKFAKSSERRVVVYDVYDQWGKNLEVSKRDMQHLIALLEKEKIRPKVLDRLPLAKVADAQKLIESKAKLSGILVCEPWMKTKKRALYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVD7</accession>
    <name>A0AAD2FVD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="229"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="529" mass="59974" checksum="C4AE445DE05560F3" modified="2024-05-29" version="1">MGPFRTRTVMAVPMEQNDFSSSASQMGLEVPLMEKQSGWQARRKRKQQQQQQKRKNEEQELAKQQRVLRQQRQQQQQQQQQQHQTQNYYSNKPSPSSPPTSKTKQNPDTPETIPDDEFDDPYESDPGESYRDRCERMEAESFQQTRSCLTIPKFLTNPKRRSRSEPTRTTTTPLVEEIANHADYINPQSLPKDLQQLKYSEQSEIGDGSQPHDWSEISQPLRPNRTHLNISHWSDFGKRGYMEDRYAIQNLGAVQVEVSPIHINSNSQDHQHEVTQRTSRRLKLPLTWVGIFDGHGGEKASQFCADWLAKYVQNEDSYPFDLGLAMKNAFTSIDRDFVHSGHPDGSTACAATLVGGRRIVCANAGDSRAIVVRKDGSVVRLSRDHKPGVPDETKRITDMGGRVIYWGRWRVEGLLAVSRSVGDASLKPYVSAEPEVCEYDIGKDDWFLVISSDGVWDVMDNEEAAHVVIASSCVMQDGRLKIDTRRFQWAARNLIEHAKSCGSTDNFSAVVVDLKSCGNPSSKSGIYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVN2</accession>
    <name>A0AAD2FVN2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">3-dehydroquinate synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS14993</name>
        <name evidence="13" type="ORF">CYCCA115_LOCUS14994</name>
        <name evidence="14" type="ORF">CYCCA115_LOCUS14995</name>
        <name evidence="15" type="ORF">CYCCA115_LOCUS14996</name>
        <name evidence="16" type="ORF">CYCCA115_LOCUS24007</name>
        <name evidence="17" type="ORF">CYCCA115_LOCUS24008</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002445">
        <property type="protein sequence ID" value="CAJ1969983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002445">
        <property type="protein sequence ID" value="CAJ1969984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVN2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08197">
        <property type="entry name" value="DOIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF1">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="10">
        <location>
            <begin position="109"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="11">
        <location>
            <begin position="220"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="436"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1954401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1954402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1954403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1954404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1969983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1969984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="55689" checksum="E440806C8866A4FD" modified="2024-05-29" version="1">MKTQTMNLTQPKVTPGTIDEDDVYRNRFARPGKPLESNIIIESGALRKLETRGREFVPALCHEAKNYLVVDEIVDEVYGDKVLQGFRDAGLDVYKIVTPADAVDESGNPSAERHKTLAVFSNCVNEILESGISKNSCIISLGGGVVNNLCGFIASSLYRGITLVHITTSMMGMTDAAIDFKQAVNHQLGKNLLGSYYPATNIVIDPEVLETLSKRHILNGISEALKHALCQSRNMTEAIVDPLDNDIHQALRNSEYLEMVCRECIDHKVPTLTHYHESDFNEMVPQYGHAIAHAVEHLSFHSKGVSPLLHGEAVAIGMCVTAEVSHILGVCDESTVDEHYSYVSRAGLPVYVPDGIGIEGIQNKLCYDKHYVKKPTMGLLAEIGKMHCNRDGSFSVEVDNEVINQALVNHMKRRDEADRCSDLYTIEASNTLKTGHPSSAGFTVASDGSDSNPASDRSHSRSDSMESGSDRSSSPATFDWDPMTAKTFGTRQQGISNCYCNPWECQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVP9</accession>
    <name>A0AAD2FVP9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1033" mass="117496" checksum="59C66C17B6E509DE" modified="2024-05-29" version="1">MINHLLLVSCCHRRIRTIGAITLILITTNIGPIPSILFFVEASSNGFPGTLEGSPTSALSDNWWLSSPTAAASFESSSSSEWEWEADDSIDAILSSSDTGESMNNNENEMVVQEVLNNDNNNQNNNNNKTQSSINSSSSNNNIQEDDQTEPIPSESSTNAQDAESKNKPLQTLEKLQQMLDETDYMTTGRNSNTNNNNNNNNNAATLGGGERQELWTSKDRSKYKKQQKKNSAQQQNKQQQQQRILEMVQEEIEEQQQNRVPPPSSANPTQAWNQQQQQHHQQQQHDWYQPPPHQYYQPHFNPGNPNSGDMIQQAISLEADTTEHSDTDGDGLGYTLPNLPIYLSDNEDEDTDDSDASTTITLTTATDDSTTTGAQNPGIIGNDTIGGNSYSAVPPNTNIVTNYVPPQQQQQQQQQQMSTISSPYHASSLQQRQQQIQQQFQNQQQQQQQQQWYGYPYAPPPPPPTGYVVPGQQQPYYPWGPPPPPQAFYYPRPFVPRVDSTMRRGPVQQQQQQQQQRQQQQQQQQQMPQDIQQQQQQQRRQQQQQQQQQQQQAHLYYQHAHDQGQNSIIDTSTQRSDESQSQAMQFTVMDPRSSPSSKRRGSGVWNLMQIASCISWAMFMAYSAVSPGHNLSMYEFNQRYYEVLRLVAWTGLPPLATFWFGMVDVLDERSIDGISKKRSSQITLDNYDENENDENDTETDRPIRRRNPHKTTMSKLVSAFFNSFTWGYCLLFALQVVATTFARLAIFFRWERSVFDLSPKIPVLVIPWVLRENGYKPKRITLIVQDFVSSCLLGPIIEEYLKVLLLRMTKLPKNFQWKKATKSQKKKHGTKHIAELIENPKGEVTNVNAYISNMLAVTLGIKLADSIRRVCMYTKPQNAAKTFYAIFRGVFPVRELCGTITALGLARRDVLGQHVPLWKILLPATVIHGMANFRGMKPVFKWNSATPWVEMQLSPPTVDLSSMKRLELFNLVFPKVLWLIILIRVTGYCVKNYFMVNRQAVKRTTTYAGKHSAFSAELAATEMLKASSKKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVQ2</accession>
    <name>A0AAD2FVQ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS14820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVQ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="69"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1954225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="203" mass="21089" checksum="1629C7A1B559D491" modified="2024-05-29" version="1">MNYNNCNRRVSSILLGSVLKRHDCAIVSPSNFTTKPASSSSSSSHSFRNFWGAGLLKSKNLENTGSVARDLLAAERTFLAWGRTGLGFVGAGTALFAAYHQETMAGIRTDIVLPAGILITNGTFLLLFATRRYVVVSQAIQSNMFPLNVTGTLGAILGSGVGTVTSLALVLNTELKKNASPAESPAASPAASPAASPAPSSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW07</accession>
    <name>A0AAD2FW07_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS15056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042093095" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1954463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="202" mass="21380" checksum="53F787DB454214D7" modified="2024-05-29" version="1">MNCFQTVILALAVFGLAHTVEAFTRISAPLARPTTTLGPVARNGLGYEEIEIGTGRNVFPGDAVLCYYVGQYKTANLLGEKTVTFDETLPGEPAEFIVGKGQVIPGFDIGICGDMTLDIPAMKIGGDRKLVIPSALAYGERGAGDSIPPNTDLEFQVSVLSATSKEGLSKDVLLKGFAGLGGFLVFMAGFGYILLQTVFLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWH6</accession>
    <name>A0AAD2FWH6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="383" mass="42165" checksum="0F63A38295E1926C" modified="2024-05-29" version="1">MMTKNILITLPNTRQGQGICNAFLQEDDDSFKLFGTVSSSSSSSSSTHESIMLKQKGITPIKCEIGNPESFENALKESQASVVVLITGDEFGPRNNISNNKLTTTLAKKSQEDCEFENAKILIDTCTEHQDQIDHLFFISLFACDEVPDSLTSYKAKHHIERYLWQQMSVNMGCFHYDIIRSGVLFEIMDGGRPMNSLSRPGKLMSAFAPKVKIPYVSSLDVGKAVIAMLNDPDTWGSGQILHAVSSIASGRDCAMALSTVSGGETCKYQQVPTMFLWLAGFGAFAKYFNQFASTHASKRQKEWHKEFLEVVPDTVTLRTFFSGIGQWSNGTNKFGTPPPTGADSGLQKLVRPFQTLKIADEGAEPQVNDVGVPTDYAVIRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXU9</accession>
    <name>A0AAD2FXU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS15087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="154"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="415"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1954494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="621" mass="69412" checksum="3E4F0040FBDFA035" modified="2024-05-29" version="1">MEDLFTFLSSSARLNKKNNKPKKRPREEEVQQVESDDEQDNESAESQDDDDDDDDEEEPSRQLSRDRTGKRDTSEKKQQQIHKEQIAAFRKSMHIRVANKHDPDLPDPMPSFSDMSPPTWWKKQQSFQGIYNAIQRNIEAGRWKEPTAIQMQSIPTLMEKRDLIGAAPTGSGKSGSFLIPALYISSAPHDIYYGEQPNTSHSPRKKKKKKKLDGNTNAKSSREGEIRTLVLAPSRELAAQLHREVERLGMGKPGGLTSLLLSKSNAAHVISNTAGGKSGLDVLVSTPLRLVDAIEKGMRLDSIRLVVLDEADRLLDGADGKESTRGKPNEKGSDDEQEEEEEDATNNASASGSRQTQTFLAQMDSILSALPTTATRALFSATVTPTVRSLAESILRNPVDLKIAAKGSYGGANTDIEQELMFVGREEGKLLAMRQLKERGQLKPPAIVFMQSKERAQALFAELLYDGMHVDVIHAGRSRTARDSAVAKFRKGETWVLICTDLVARGVDFRAVNMVINYDLPTSGITYVHRIGRTGRAGRKGKAITLFTEADFENLRTIANVMKQSGCKVEDWMLQLRRSNTKQAPRRSTIDTTPNYDKKKRFKKKQMINHSKKMNQGHKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYA4</accession>
    <name>A0AAD2FYA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041936038" description="Proteasome alpha-type subunits domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="3">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="277" mass="29840" checksum="9FA9C541D2553D87" modified="2024-05-29" version="1">MHHLARYRWFSLLVLGFAMVSPVRGSSMNGRHSFSLTTFDPTGKLGQVERAMEAAAMGTPIVAIINEKTNGILLAAPQILPSVFMVDDGTARFSSVAPHIAMTHSGISADGRVLIAAAQRLAVEHSYTFEEAIPIDLLLEEMSLLLQEYTMKPGSRPFGSTLLVAHLPSAVSGSDPDQKPQLFRIDPSGSVTLLEDGVAVINGKVSEDTKSKLKELASQSTTSKKIGGDDLKQLCDILQDSISPKVFGKMDAETVQLPSCTLGVSFTPKNGLRIQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYW3</accession>
    <name>A0AAD2FYW3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYW3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="490" mass="56771" checksum="13F46AAA6DC56912" modified="2024-05-29" version="1">MMSLLSVPASPSTAAPTSHLYRLRKALIPLLCFVVGFNINFGGIYHDISDGSFGGHPIIDATKEWKSLMVKEKETLSLIIEKGEKDNKKDNLGLNKDQAKADEAERRQYEEESAILRDHMKRNIEDYGFDPWANQVYDDDSEDEEYWCGEYCSTPKGTCWRNTTITDHYRPPNITHTTTTATPAMTTERTKIRRRRGGKPIIPRRLIFTYHTNLFDCTFPPHLYDNVQKTIQTYADLWGIENKSNVEVMFFDDQDCARVIEASEPKLVPIFWAETNGSYRADICRIAALYMYGGYYLDVDIEPIQALDPLPQVDFITAQAANRVFFQAVMASTPRHPLMKHTLETMLVDWYMIPKIMKDYGKTEYEPLWFRSQTYADMRLEHVVQYGFDPHHSIGILMGPATLRIAYDRKANLTTPWLLDEFENKAEKVYPALIRETSHWGCNFMVHDNATKTPYFYSRCKGTANCPNYDEKKKSHDEKKKSYDEKTMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZN7</accession>
    <name>A0AAD2FZN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS17092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZN7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="794"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="808"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="885"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="916"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="931"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1958240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1223" mass="132903" checksum="3ECAF63CC92A37B8" modified="2024-05-29" version="1">MSEEVEKQRSRRGSKSTRANGEPKHRSSRHHRSSSRDSHDDDILGGSERKSSGSKPERRRSKDDDDIGGSRKRSSGRPSRRKSRDSHDDELGGSLANSQPPEKRKSTDSDNVIGKSDRRSSERPSRRKSRDSHGDELGGSSGNAQPPGKRKSKDSNDNVIGSRSDRRSYERPSRRKSRDSHDERSSVNGSSTSQDSNDSGSAKTEDKKAKAKSRRMASIPAMPGAFEAKSTEDKAVRRKRDAAYKGREAGDNDRESSDREAKNRARRQPGETKPGSSIEIMDRRAKDQAWRSVGSDIRPGASSHESMDRTVKDQAKRSVGGAVRPGASSETRGSREAKSKRDTSRQSTEAHEDEISLPPASKIGWTGDVEAVEAIAVDEMEATIPSSPQEVREEAPNETEEEDGRATARREKKSRKYKYMLAAFVVFAIFAGVLVWLLVLRDSSEPDGVSISWIFAPPTTEDCLAISQGVETADQMGATVKYFGVEMDFAVAPNVDLDFLESELQMRIQLDVLPLVAGCDKEGSISTENDSFIVENSVLNSISIGDLATCSSNSEGVCSFVYLQLDLFSKDANVQSAVLLALISDVFQDEGLLELLNLLSPVEGIDYITAYEIVLSGGPSSSPSIQEDGSPPIDNGSPSQETCDAIANGTPVSGREDLVVQEYDILMDVVLDSETEELSPLTTELDEKIQRFLLPSLVGCETKQRRRLQIESFVVNALVDSEGNVGGSCLPDSETPCHRYVIHLDIYVQRTVSSADFSQDILEKFREAPLVERLGLLPPFQNITVVDIASDAASFSPSIPPSAPPSINPTTSPVTYPTTDVPTKTPTTAPSFNPTKAPVAFPTTAAPTALPTKFPTRGPTSGPTPVPSLQPIVGPTLEPSPSPSLEPSGSPSVSPSAYPSSKPSAEPTTTASSWPSVPPSFQPTPSPPSSQPSTSPSTQPSSSTTNFQCFETSSDLSNEVGNWLTSSELKASVEAQYGPIGDWCFSAGVTSMARLFEGQSTFNEDISKWDVSSVTNMEYLFYRATSFNQDLSLWDVSSVTNMLAMFTSLESFNQDLSSWNVSSVTNMDVMFRDTPFNQDLSSWDVSSVTTMSAMFAQTPFNGDISSWDVSSVDNMFSMFQDASSFNQDLSSWDISSVTSMQRMFQRATSFNQDISSWDVSSVARMQFIFNGASSFNQNLCAWGSRLSSSVPVMNSFLNTNSCPSTSSAPDLFANPPGPFCHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZQ1</accession>
    <name>A0AAD2FZQ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="7">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="7">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS17122</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZQ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="10">
        <location>
            <begin position="38"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="9">
        <location>
            <begin position="304"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="363"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1958300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="428" mass="45159" checksum="06A349CFA2852586" modified="2024-05-29" version="1">MFHRLAARSLRSVSASASASNSSSKCHKVNFQSKRFLNLHEYQSSAIMEQAGVNVPFGIAAHSVEEAVAAANQIGDEEVVIKSQILAGGRGLGAFTNGLQGGVHIIKTSEVEEYASKMLGGTLVTKQSGPAGKPVNTLLIAKKMALARECYFSIIMDRASQGALIIASAEGGTSIEDLAESNPEKIIQVPVDLQRGITEADIETIVNGLEVAADNKAAAGEQIRALFNLFVEKDCTMVEVNPLAVDFDGNLLAADAKIGFDDNASFRQKDIFAQRDFTQEDSREVAATKHDLNYIGLEGDIGCMVNGAGLAMATMDIISMKGGTPANFLDVGGSATTEQITAAFEIITADPAVKAILVNIFGGIMRCDVIAQGIIEASKTLELKIPVVVRLEGTKVNEGKKMLNESGLQLISANDLDDAAEKAVAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZX8</accession>
    <name>A0AAD2FZX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS17039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZX8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="65"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1958132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="316" mass="34714" checksum="50E6E1C429097CED" modified="2024-05-29" version="1">MQSNHSKTSSDPAANTSSPSINLNHNFSIQTMNRPQNAGMETEGVVPIVALPEGNNSFVGMRISSGLPFPFKLHAMLDNAAEGNYETIVSWSGDNGFLVHDKDAFVEAIIPKYFSQTKYRSFQRLLNMWGFQRLREGPRKGAYYHEQFQRGNSSLCGKMKCEKIKKKPTPGGANANGNVNANANAKSKEPKQYKANVLALESSNEVEPAPSKIAEKKVVTFDKATKPAAKVLDAAAPLPSFEDTFGEIKQIIPVGKRKTTAKVDHPHADTFDPNKQQSNQSAPLPTYSDLFEDLQFHEVSKGDKIARVYGPGEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0M5</accession>
    <name>A0AAD2G0M5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0M5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1958972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="344" mass="38835" checksum="ED2D24CE53044AB0" modified="2024-05-29" version="1">MANKLDILEEIRKHRNNCVDLLQKLQKAHVNGDDVANAKNKSGWLPLHFVMVFCKGPGVLELVKFLWRMHPLCLQAKTDRDTLAVNLMPPTTNPQPVIDAMQRDQLEARVWLMKKYPQSIRMEDKDGETPLVRAIIGRCNILVAAMIQRFPELTQETNNRGRLPLHYAMESANAGAVSMLYGAYPDGIEEADNMGITPYYMFAKLPNKDPLIAALVDLMCEVFELDEATQPSKDDSTEVIYKQMLPQYAIDSNLSVWTEKVIWRLIKNWRETIQMPIPEIPDTPKENQHSTFATSGALNAAKDSSVGDVGKPRTTRDPTSFQKYTKKGQFEALRASFEAASVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0R1</accession>
    <name>A0AAD2G0R1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="13">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS17740</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="13"/>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0R1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="159"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="92"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="515"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="679"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="753"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1959318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="819" mass="88292" checksum="66D07F921CEF219D" modified="2024-05-29" version="1">MNNRFVRATTTTTVTKQKAKNPLNQAGLDKLQEVYDKASSNPNSNYVFTVRRAMKSLQSCPTAITTQKEACQLKYVGPAVAKVICPTFLPSPTSSTNNYNNNTNNNDSNTQQPSRKRSRKTAASSTVEQGPSKKEKVYKQERLAAESLDLSNCGPWKVILIIDGREHKSQHVVSKCKQSGIPCEERNLPIGDMAWIAQAQDKISGRTTEVLCGTIVERKESSDLVGSLFGSRYLEQRMRLKSCGVPQLLFLVEGNLASNINCPQETLEMAIMETRCLGFHVIQTENLMDTVRKLKGLHRRVLQRTFPEAFSQLPTYTRSPTGTFGLHRKRRPTSLLEMTFDTTPKPALGAKRFITYTELKAKVELDREAGTRTVGAIYMAMLKQISTLSHKKCEALAKIYPTMNALMTAYATSDNPAKMIQDISLGTQKMGPKSSEAVYTAICTQRDGTRPNGPTMEFEDIPVAKKSPTSVGPPAAANTYTGALDSFFAPKAPSPPKAKTASMTVPGSAALAALKKPASQSYSPPSPDRKPAPSVLCVDLTDDTPPRPSFAKKPSYLTDPPPSTGSSAGYNKSSTAALKGSIDSQKATPKAAPKTAVQLNFSSPLFSSPDDDDSLLHSAPFAKRPKTSTLDVALARSVSSTPSPAASSTASNSSTTKKKAPAVAAKAISSPSIVVMIDSSDEEDDDELLMKKPLQSKANAPSTVAAKAAEAAAAATYSIPSSSPNTIRRVSDGSSISTASSSTTTGAREVQQSKKPTATFDQTTANVTMRRTNKNSNPPNRWQDALDSDYSDDEDDLGISLDLRSRLAKRSNTETIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0S5</accession>
    <name>A0AAD2G0S5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0S5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="237" mass="26046" checksum="3EAC5FC5E825A9D7" modified="2024-05-29" version="1">MLRTRTTAVRVARTGILHNLSKAPKAPSIFHLSSWEDQQSCCFSSNTPAQEDEKSTFNYEAPMGGLITRLKIVSISSCVLSLVGLPLLIFLKSGDLPTAKQAGVGGIALFGATGSTLSLHFVFGPYALSMEEVPAPEGTDDAKNTAFLKATTRSVFGWKNEYVFDSLSAVEPYSGTRPFANFMINGQTLLYAHPELLDEAMRRRLIYPDGLPEEIEAANMERNEGLPKRKEDDDDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0Y6</accession>
    <name>A0AAD2G0Y6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001975">
        <property type="protein sequence ID" value="CAJ1958383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0Y6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="528" mass="58080" checksum="2E29AE89CA49D18F" modified="2024-05-29" version="1">MDTDTREYTSPKLEFYMRGEKTSYTPFYITTTIGCLQFVKMDESSSNKSKYSVAILCGRPLFAAMSEQELKAGKSIIVQNIVQDASPSTFKNTATTWLSVLGTRVQIGQTAFAAASGLVSRSYTNLVLVSPATVDGNDKQSAKICFPPDPVCAWLAMCLMDDSWSMALSKDMTLNGRPKGDFGEVMVALYFLFFADIVRGSLKDNKDYNTFSVPLNDWINCLINGGRSGDDGDDGDDMMNQNNDCQVHFSAIQVCCNYARAYDDLSSLLQNEVFLDNMYKTGVGLYVFAGCSVIDVVFALQISVAAPTKGDVTTTRSSSSKKYQYVPMFVSIKLQSSFCPKSSSIECDKMKAKFKAVEGGSELGALCLLVVFGSSVKSKDGDYTLKPDCVKNLEEGMAVSKVLRIPTNDIFELTEAFWELTGVHDEMSEVLASHSFLGAHQEADSETTTNNFTEQVLRLCPKLKTKKAAEMQGIVRATDEVTGYLEKLLAGLDDIVRGQPSDGEKEKQTKQKATEAKTTKIQKPCIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1M3</accession>
    <name>A0AAD2G1M3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002010">
        <property type="protein sequence ID" value="CAJ1959609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1M3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112103" checksum="62B3221C92ABCC59" modified="2024-05-29" version="1">MGDVQTPLKSRSDAPVDDSDSSQNSTLSQDDQTLPSTPASRNNSPQLPPRLKYRPGATDNFLESLPSNHRFTSARIQPLDEPVCNIGNCRLEISTQESFPQHVLNQKNEKMLYQVVYRGVVSLLREPGIKSGVHIGYGEIFEGIALESNDEHAPSWTRVTNILTGGYAVDAANTKNVAILDQTPKRTNVANVAAVRTSSISLPIPLPSSRSGEESSVVDVTKSESDSDSRYGYIFETKGDIPICIPINFIPKVEVGEFVYKVISSNPVPIRTGPALDAPCTTVALMPGTSHEVCLRVLAADRSLVFLRLTRRRGWLMEKRQSRKYPERLVRVMHDITDSKESQSCNMSFASSSSSSLVATPGSAARRRHRPPRRRREMQIDESSHSPSHVNTSSSFWQDSPNNSFDMSSFGRGIKSPSSNASMLLEGSSLPVVQREKEGRTDTESAPLSDTSQTGFFLIRVSAPRGLKILDAPHFQVNNLIHGKHTPISNKIQAKGKNEPGTTKQSIFQTMTGHHTTALTSKTGSPAVFDSVLRARKLPRGCVFEASKRMDSKGAFGEGDGLIKLSDNSGWAIVPKQEELEMQYKTYSGSLAKAMEGEVTRAFEEVGNAIVKDKTQPVFMRVYNKGGIAVSCPPASSLMTDDETSITSPGSSVAGTSAVNGGFGHAPSQDSDIASSVGSSFIDAMFRTPKKKDFDHVSLASSKDGAQSNKIPPIDKTAISTVIPCGMYFEVDPWVDVRNSEQSYCSNDFARIRGGQGWIPRFVQGKTVVNVIQGPNVRFGSFWFRVSQKEGIKVRKGPSTRAPSIRREDGVYFRFECGEYLRASEVVTFSRDNIAYESFAKLYRNRHMRFQSGEDGERTLASLTAQSEWVQISSSKTIQLVECLVEPRIERHRQGWRYNVVLDAKVKVRRGPSFEADSKGIVLFGGESVLVNERVIVPNGNVIWLRLRDGRGWVHNVGIDGEALMIPHSLKNRRTTGGNKQSKSKERDDDIAYNTIIARLFHNESDSGSQQNQGNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1P6</accession>
    <name>A0AAD2G1P6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1P6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="220" mass="24355" checksum="CC167139072AF019" modified="2024-05-29" version="1">MSLQCYFKRLASEKGAASIILISDNARSPDNSVRRSSPRPQLDEPHREGVFPSSSLAFHDETGAESNPHAKCSDSERSRFKVDTAEHDVNETSTTYTSDGSIARFSDDSIGVISPMRLSIPSAAVTLQASTEDVLTVILEAVPSFAKPVRSSSEPIYSSCDCSLTRFPVRQANSDECCLQTTRHSLPDTIKRPRRRHHSDEREKRSDPFSKRPKESALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G214</accession>
    <name>A0AAD2G214_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G214"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="235" mass="26490" checksum="EA24401DA5E91D05" modified="2024-05-29" version="1">MNDPPNLYRDPDYQIAQGWPFEAAQQAADGNIQALLYLAFTAFNDGNGSVALKHYRKAARDFNNLEATLNVIKIYEFGQGVGADLDIIVNYGYYMLGARTSARDGRTQIELPENKRNVNDGLKWLERAAQIGRGDVASNLGNMYMTGGHPKVPRNYEKGMELLEKAAELGDGHCAYQLSISYKIGIIPVDEGKHRFWLKKAADMAHEEAVQEMARVWTPKEESKADQENSKRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G258</accession>
    <name>A0AAD2G258_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G258"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="180" mass="20439" checksum="2A318E4ECF0F230D" modified="2024-05-29" version="1">MKIIINATRLRTISDGSSSIPTGLPMVKNRPLHADRPRQPAVTLAASVVIAKRNRDSKIAKKQRKSTTTSTAGAIQHHSRTSSNKKPFCLDFNGNWRSEADMPARRIIIQKIVRSIRTRRPYAPQLLKRQLPMIVKRIEEALYKNAPSMEIYSDHSTLELRLEILARQVQEQAAATRNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2T5</accession>
    <name>A0AAD2G2T5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS18862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2T5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1960724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="419" mass="46894" checksum="5ED205638176BA51" modified="2024-05-29" version="1">MELYAESIENAVASWKTVQGLPDYKTLVGELLFREIFKISPGAINMFAFGEGVDCYNLPETLFNLPAFQSHTNGVVTMLETGLEMMLGNNMESLAEALSSLGEKHVTFGIQPPHYIIVESALIRTLEVGLGENFIASLRKDWQAVFRFISRTMMMGSENRVEIVKSKRRSAEQKKVATLRLHSISPGQRSKALTRHSRTDFGRFEGEPKGKHRRRGTSSDPPHKPMRKGTEESLRRARSVSLHLDDDDCPALDDDDCPALDDLTIDITAETRAMTVSDHDESDNAETIWAWGNDTNVEPPKMPLRSPSPKDPPRKVHGSPPRVPLLVRNNSFDSVSTLGSLDFAPHFPKRLRSPTRELRKPLTSAHHVEQGRKSSFDSRSTLESFDSPPLFPKRSSSPTRVPALLHFSSTFTKLLGESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G356</accession>
    <name>A0AAD2G356_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase PGAM5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Serine/threonine-protein phosphatase Pgam5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS19001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1961023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G356"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051021">
        <property type="entry name" value="Mito_Ser/Thr_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1961023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="327" mass="37252" checksum="2EE5A716393A056B" modified="2024-05-29" version="1">MSSYAFRFARNSPAVAAIVTSSWSFSSSSKCDDAPVAEEKITTGLPYTGMKLDSKGDFHNLFPRRQLWQPKQEYPWWDKDWDGLNPARSGDDEEDRKKMRKLRKEGVTRHIILVRHGQYDESEQDDSKRILTEVGRQQADYTGKRLKEMLDGVNEKFGPCNIKVVRVSNMARAKETADIIASHLPGVERSLPDPELNEGRPAHNVPGGKASPSTIKKTDESHPRIEKSFQKYFYRADPPNEEEEEGDADRPKHEFEVIVCHANVIRYFFCRALQLPPEAWLRLCTFNCSLTYLTIRPTGTVSARMMGDVGHIPYGLTTFSGHPGFNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3D5</accession>
    <name>A0AAD2G3D5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3D5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="278"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="75836" checksum="7084C0CDF9B3E9F3" modified="2024-05-29" version="1">MGELEEEMPFPAGGKVIFSGFMKPSDSHEDKPIDSHEDTPNSQKTEKTLPESVVSDSSDEGVDIPHFLQPLLGMDFMPFVQSTGSRGTISKNSPEPSPKGEVLQPNTSAIAVVTDEPREEQIAEEDLDGYAQEYAEIVKAAKRKKKKKKLIRLIRKSLGGKSKASSKSEEEDVEPSEEVNLSMSTCESFSLQSLDGDCDDASVVTSEFLNSSNLDTSIDCSVSSTTSKKNTGRSFFKRKGKKSKAASTNNETSIAAHTSGHSGAEGTLKWLKTQQSCMQNHQSEMNQVQSDMLALQQRSNGIQKRMFAVTDEIAALQSALQMAEMKLRNELNDFEATKTEMTRLEKSAEIAAKAVLESFKTIQNGPPGEFQNIEPLTPSHAADAATAPTPKIGNSDSTRQLASFQEPQLDYEIKADAFMRVHDLNIENSNTSDNPGFLYVDDNLKPILENLAKLGLDNIRDESERFKATRDTKKTLSKYEENGTATNSVQGKDVLVWMGDCGHKNHGCRWPVVKARGLIQTSPKELTEFMLDSSRIKEYNEMSQGRDDVVVFQQDLHTSAEESAIGLPGAIKVLRSRNKPKLLPKAIEITSLMYAKPLEDCPGAYMIVNRSIFDDAEGTLINDKEKITSEMLLGVNLIRPAEDGKTGNTVSEFNSITHIYPPGVPEFLAKKVAPASATNMIKDIQKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G551</accession>
    <name>A0AAD2G551_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002131">
        <property type="protein sequence ID" value="CAJ1963105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G551"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="52"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="221" mass="24695" checksum="F4FD54D30F5BEAD0" modified="2024-05-29" version="1">MYGFEIPKDYNDAALCLDQIHGNTKWQDCTKLEMDQLAKHKVFVDIGKGTPIPKGFQKIRVHLVYACKHDDRHKARLMADGHLTLVPVDSVYSGVVSIRGLKLMIFLAKLNDLDLWATDIGNACLEAYTSERVAIVVGPEFGELEGHTLLVSRALYGLCLSGKMWHQRFLACLEEEGFFPCKAEPDISGCAPLPMESRMSTLASTLTTLHWQCETPSHSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5K8</accession>
    <name>A0AAD2G5K8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5K8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1963207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1093" mass="122622" checksum="582D1CCC59B44632" modified="2024-05-29" version="1">MDTITNSDSYGATTTDHVKGAAVNQQRNKMDMTICIDPNRGSEDADDMSSSRLSKATLLRGNHALNFQFLREGTLYDRDHQVEALTGALHRRLRPDSTPEFVLIAGITGSGKTVLARKLKQPVQDKDGVFVMGKFDRPKQSQPFAPLVAAMTEFVRLVLKKSNDVVDEISAEIVSQVGNDIGVLTVLVPALEDLVGRPAEGSLFTLKSVDAAVRLKEIFVKFVKAICIRPLVLVMDDLQWADSGSLELLEAIVCDKENHGLVVVGICRSNEVFYTHDLAVMLRRLEDEKHIPIQTIDVKGLSIRAANSLIASVLRSPEQDCFGVTNIIYRKTKGNVLFTVEFLKALFEDSVLKKDPVSRTWLWDDDLWAAKFEQADSILHLTLRRIQRLPYECQSLLLYAACLGTELDEDLLSKVFVDSLTVGAEEKSVLYDIAESVAHVDLDRAIERCAAEGVIIKESHACTYRFSHDQLKEAAYNLVPQSELPSLHVSLGRFLCEILSRDELEKYIFVVVDQMRIGMDRVCSDFERSRLASLCLVAGRKAMTSSDFNTTLKFLELGISLLDLRQSWRDEYELTLSLYNTIAQATCCLGRIDIADKAVATVIEYARTFHDTVHCLMLQIYTYGTRMRLNDSIDLGLDVLERLDEPIPRNAKTQQFAIELLKVKRILKKKPDTAIAGLPDMTDPVKLSVMGVLNLLIAPCFIARPKLFPLVAFKLFKLTLNHGASAVSSMACAGVGIAMANVGDHDTAYRLGQLALMFIGRYNSVRNDWIPRVYVAHYGLVALSKERIGPVLQKLAHAHQVGMQCGDVEMGTIGLHMCRKYSWNVGYSLIELEPKMKAALDQMKAQNQLLWYEMTHTCYEAILILMDRTNNPAVTNGCLMTFENEKGSDRFNEILQTANLEIEIYLCEAAAHKMVVLYHLGEYGKALEMAKRSRNARKILGTSMVVSYQVAYDAFTCMAVLRQRNTSSPIQKKRLLVQARNCLAYLKKMAVSVPENYLHSIRLIEAEILAYQRKPQQAVAMYVKSQELAREHAFLGVLAIAFDREAFARKEFGMEGQMECYQKAIGCYEEWGAFAKSSKMKQSVERDHSTPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5Q7</accession>
    <name>A0AAD2G5Q7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS20344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5Q7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="601"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="672"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="270"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="683"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1963823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1061" mass="116174" checksum="45DE655EFA14F534" modified="2024-05-29" version="1">MPKKQKEHSSGRHKSSRSIERSSRQSKAREVDEEPSESSYASYIEKSERSNKRSSSRRSKAREADEEPSESSHTSYFEKSERSTGSHHRSTHGSRSPKKDSGRSSRRSSSSRRSKTRETECDPSESSYIEKSERSTGSTRELRSEPKQRSPKKSPGDRRKEQSAARASKPGAIPDLNATNNSGDRRKERSAEKASKPGALPENDGSVPADRKKGRRSTRSSNPAVVPEDRMTHRERRKEERASRSSNQARTVSMTGGMLEAATVDDDPEGQQVQLVRREFEEEIEQLNQRLYAERAEREANEDAQQEALQQERTKRRKRNILVVMVCVVVLIAAGVGAFFALNKSETTEDSKAANSNTEDPTTAPSSAANDGTSAISSTPTSAVSNSPTVTQLYDPPSEDVCLAISRNETITGQVDLDQREFDMAFDVTLETDGDITVQEVQTLLEAIQTRLLPPLAGCSSQTVNRRRLQTANEQSMIRVVVAQKRQRQLAIGENRYVIFNVFVTGREDPDVVCTNTQDSNLCHRIVVKVTAIFKGSVPLTDIVVLTSEQVTEKLKDEEQHDGNLKDPLGLGNPFSEVQLINIDNQSATAAPVVGATWNPTQMPAQAPSSPPSMVTPVPSVNPSIAPVTGPTPPPSALPSAVPSDPPSVRPSYLPSSSPTVAPVVGPTLLPSSAPSKVPSRVPSLSPSALASKVPSANPSIGPSIAPSANPSKLPSMNPSLKPSIKPSMVASAIPSTKPSMVSSVAPSIRPSQTPTVYYQCFQSNSELSTEVNNWFGTGLQKTSVENTYGSIGSWCFDKGVTSMSSLFLFRSTFNEDLSSWDVSSVTNMQQMFQVARSFNQDLSSWNVSSVTDMWAMFWGASSFNQDLSSWDVSSVTDMQVMFDGVSSFNQDLSSWDVSSVTNMQQMFKRAESFNQDLSSWDVSSVTDMSEMFYAATAFDQELLSWNVSSVTNMASMFESASSFNQDLSSWDVSFVTSMWAMFYRAESFNQDLSSWDVSSVTDMDVLFYQATSFDQNLCVWGSRLASNAKVEGAFEASSCPTKSDPDLSVNPRGPFCHVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G629</accession>
    <name>A0AAD2G629_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G629"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="43875" checksum="7EC23B35D712A249" modified="2024-05-29" version="1">MNRKLEKLAKRKQEKQEVWRDEGTKEDDDNFGSRNITSRTDGDPDRIPIFNILEQAGFDTVNDPRFTDEVLQSLPKWSEVKELYGEPKVMGLETCEYYRESVDEAKWKLAVAGNFNSGTNFLHELLRKNCVSPPLWQVPWGKHYPAYFRETNQVQKMKDVHYSNVMPVVMVRDPYTWMQSQCRQPYNARFDHNKSTCPNIIPYNTDIIDHPRYASMKYVPIHVTYSKEPHLKYKHPSLAHFWNNWNNEYVYNRTSEFPRLIVRMEDLVFHGETVVPQICACAGLKTKGKFHHKRNVANWNNGIDKNPLHGAGLLQSIIRYGNPETKRTGYTPCQLWAAKNILDNKLMNAFGYNYVEKFGDSPSDWADCFGYLKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6A0</accession>
    <name>A0AAD2G6A0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS20319</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6A0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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                <person name="Bilcke G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2416" mass="264543" checksum="7776C046B1A31F1E" modified="2024-05-29" version="1">MGKKKRPQKTKGRKSKARNRQSNKVTDSSDEGDESFQVDEFSSDDDEALIIHDEETRADRALQQETVAEEPQVGAVETETAKEDSKVDNTDGKNESPESVPKSVPEAAEEKETPVTEGDNKVEETEKTEEQTPESVAESVLESILDSATPVTEEDKPAESPEDVDATETEKSKAAEAPKNMFENIGRFFQKPEGSKPEAIKTAEREPEAIAKPFEETEKTPNASEEQIELTEADAPPEIGTSEPTTNVTGTSTARDSQNLLENLGRFFQPKPQESASKEAKDVTDKNEEEDADIHETDDKPEAKSEQPVSNEESEPTTETSTTTEEPKNLLENIGRFFQKPEVSADKELKDATKSDDIDTDTKDQATKDQPEQSGASEKTPSSEAVERKDDNKEDEKGPDLISNFKRLFGSDNDGAAAKTAAAETLSAQEPGKTEEETKEPAEEDTGPVTTESNGDDPSKVESKKEVATPRESAIMTGIKNLFGGQDSLEQGDARIDPKEESKDQGDESSTQVESPDKATSDLAPSKKESPIAEKSLDSVEKNTDVEAPATEEPNEAKEETKELVEDDANPVMSESKAGDPPTAESKKEAAAPRESAIMTGIKKLFGGQEGDAKDDEKEESNDQGDEPSTQVESPDKATSELAPSAEESATADKSVESVAENENEKNSDAEVIKTLRKSSIVANFKNVYEGKEAPEREDPVPAVEALAPDESDETKEDMRETGEEVTSESHTNEKPNNENTESNKEAAAPRESAILTNFRKLFSGQDGSEQGVAKDDPKKENSDTADGQATEIDSPDEPTTESSASPTEESATADKVVDSMAENEGEKKADAEVIKTLRKSSIVANFKNVFEGQEAPKQDSSSDDSNEQHNELAATHDKRKKSDAEIQDDEKIGAEIDQGAKTVRKMSKVSSIKHLFESPKPAEKPKMAGGKHLFESPKQDKVPVAAIDIPVDGTYKSAERKASEVKGDEKPDKESDPGVKAVRKMSKVSSVKHLFESPKPEKDSVASRIIKSPAATGISRDRNAAEVRRNEKTDEESDHGTKSVRKISKVSSIKHLFEGKDAPKQDEVAIESTKANGQIVVGGESSKGDDTAEQSQVELEVSPEEPAAVYTLDEYVSDLKEDHKPETEAVEPRESVIITNFKKFFAGQDTSKHHAATPDPKDAPDDQVADADGVEPSGTDDVVDYSKVHSLEETATESDNLVLNKGSPAEVEGEKHTETAAPRKSMLLSSFNVLFGGQADDGSSRPSEHDDDLSALIDNLDSTKSMDKDEAKQQLRGAVATGMAANMLQNPDKEEEKPTGAKQLRGAVSTVMAANMLQDPDKEEEKRTGAAQLRGAVSTVMAANMLQDPDKEKEIPLPSPTQKLRGAVTTVVAANMLQDPEKEKEISPPSPTQKLRGAVTTVLASNSLTSHSPELESEEGKVKAPTNANEATFDQSARSEDSGLLSNLKRLSEKLYTPSPATQSRKLEMEKQEKLKLLAEHLSLDEDETQETLIRDSVFDRNVRFLEPGIEEDDAEESNSDSVSSSESSESDEEEYTNEEMYEQLQQATNENMEMAEVLDALEESHRAIEVLQNENKKLEEESLRMQLTLEEAIDTNLVLEQQIAKGAAASDASGNSESAKLTATIEELRAELNDLYDQNENLVSQLSEIQRKAIDSKSTMETFGTPTKLPDEFLRTPQAQTDSSMDVVVETFGTPTKLSEEFLRKPQAENTHLVEAANGELATLLAAEKSEKEALQRQLTAMESQLQEDSNKLLEQLNAGKDRNEALKAEVAALDLKQATLSQTLEELAAAKNQNEELKKKAQEVESKQLEENKKLSKVVEEKEIEISKLQNELSDLNEVKAAMDEPQPRSSNRRPSEFEMTALQVQKNRASSEKEKLEETLMSVLEEKDELEASVESLGREKRKLEMSAASFKGKHEKSNQKVESLEAELSEAEEKIEQLGAKSKQQSAELAELVEKISELESSLTELKEENTSLEATLQSTADSLKSEKETTEKTIADLTAQANSKAEENKGLEEKLKTTEESHSVEKKSLEDTVAKMKDQIDVQMEENNSLRINLEQSVADLTSQVTSQAEEKKALEEKLKATEESHAIEKKSLEDGIVTMKGQTDAQMEENKSLNNNLEQKIADLTSQLASQAEETKSLEEKLKSTEESHAAEKKALEDTIAEMKDLTEAQLEENNALHKKLEEALATEIELASVKKADEEKAQKIAELSSEIDVVSADRTKLRSEVDQLSSEKKNLEQQCTGLVVERDALTASLKGKEKELKAAAGIVGNKENTKTKAATGSAPKKVLKEVENPVSATKEPTVHKQRSKVDSNAKSAPSPAKTKAKNEQAIAKKQAPASPGMTAEDDEPVEENLNSKKRGYVKRALNNKYSISTEDKIQQRKQRKKNRENFKGMKKLFLGSTKKPVHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8I3</accession>
    <name>A0AAD2G8I3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8I3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="309" mass="33096" checksum="458B6EBCFB12B90B" modified="2024-05-29" version="1">MIPLLIAAAAAVEEETASEIPHDDPTSNWTAVLLAIVSLIFYWVFLKPTAQDTGAPPPTVAENNSRRVRSAPQQQRRPAAPAPAPQVMADRRLPTPQNLSDNALEVLLDCQSKPSFVTSTQDKLGLGGHKALVDGLVAFGHTEAAVTTLDASSRTERAKVLSRLGSSPGMTLSAPPSKGSTMVVSLPFLTPADSSISKLQHILQVLGSYYNLIVIGSIDPSKPAPASLKEQQEQQDSLQNILHAGDLKESILPSHRILLASSKVGRIALVRQLVKVELMVDYQPEVQAELGRFGYKVAIVPQLGSLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9C7</accession>
    <name>A0AAD2G9C7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9C7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="138" mass="15576" checksum="683E95464EC3446D" modified="2024-05-29" version="1">MSSICLTIFNQFLANKTFKLYPRIRKIFSSLLSPKAFGDICQEVHTGRLYDHHVEQLVGSTGLVEAKKRISARFSCQRFDEIFQRRLKERKNSQQQNGGGGGNNDDYREGSAMEQIVDALIEMGCTGEEKDDDDGVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9F4</accession>
    <name>A0AAD2G9F4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002304">
        <property type="protein sequence ID" value="CAJ1966631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9F4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050166">
        <property type="entry name" value="ABC_transporter_ATP-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42788:SF13">
        <property type="entry name" value="ALIPHATIC SULFONATES IMPORT ATP-BINDING PROTEIN SSUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42788">
        <property type="entry name" value="TAURINE IMPORT ATP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="117"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="391" mass="43388" checksum="30A41F3F5E42B9C9" modified="2024-05-29" version="1">MTRVLLYRYLLSLSFYRSITVQSFSIQHAYYDNHVTNNNRIPVTFSSSLLLLLQASSGASDDNSNQNDDNEDHNDNDDDGDICWHPCSIEISNLSHQYPVTLWRTLTSSEPRREFALQDVSLKLGPHEFVLLLGDSSSGKSTLLRLILGLEERKIVQPTFGTIQIAVVVPHYSKEEEEEEDDDDNATEILPPPAAVPVLLDQKPVYSNNRGSQTVQMILQEKLKKMNKASTIIQHHDEKSSQTTLFLIIERLCELMDLPLTKKGSDLSPSEAYRCAMTEASLESILTGKAAAAAAAAVNDDDDRDETSKTISSFPAPILLLDEWLDKETSTVVQNVQTSILKLVQTSGAIVVSITHKPNLYKQSIKEEGEGGEESSSHVRSITLCRGKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9M5</accession>
    <name>A0AAD2G9M5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9M5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="137" mass="15708" checksum="41AD17F40DD5D8C1" modified="2024-05-29" version="1">MYSRPVYVSHLPQTEGKRFLSWVIIFNFALCHHLMALRAADYKDKHENLLQALKLYEALVALPMEGTFQIETTYFMAMINNSAQIYQMLHRPRQAKQHSDQMLSLLMVTIQEGEADTVDGFDGFLLNATRRSLAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9N0</accession>
    <name>A0AAD2G9N0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9N0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042139028" evidence="1">
        <location>
            <begin position="18"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="413" mass="45582" checksum="1EFF993F16370CB7" modified="2024-05-29" version="1">MKFTTIFALLSASMVSAKISRQPKSPNNPKGKYVSELLQGAKPTKNSQLERRLDQNYEVDISQYSVKFQKCQFVKSYDDDLAADEDMPTVLATKRFIVFRLCPDNNCESCSNGYGEYLVDLETYLAATVDYQKGIQQAMCNACQNNCVFDDDQYNNNGDDDGAQRKLENYPYSLNCNTCYEECSKIENMEKNGYRDATDFLECTVIHDPEDDDKTALYAGPMCASSGYKIKIGVFTDQYCSILDADKDVDDYLMSDDGTQSKLSHALLKTVYTDGYCVSCAAYNNGNDDGGQANDMCDELYQESAKCEKAHGFDNGYANYDSDYQNQLAQEEIVCDFIDSIKAGSYDDYGEIVVTGANLSSSGTTTTSGQKLALSFFVFGTIGLAFYAGKLHRELTKGIGPGPGLAEQGGTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB54</accession>
    <name>A0AAD2GB54_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS23232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002380">
        <property type="protein sequence ID" value="CAJ1968423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB54"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1968423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="11363" checksum="6613E6C439266EC3" modified="2024-05-29" version="1">MKEMATYLMLVLGGNATPSKSDVSTALSAVGIEADDAKLSALIAELEGKDLDEIMEAGKSKLAKFGGGGGGGGGGGGGGAAAGGAAAEEEKEEEEEEEAEIGGGMDMFGGEGGGGGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBM2</accession>
    <name>A0AAD2GBM2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002402">
        <property type="protein sequence ID" value="CAJ1968744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBM2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="517"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="795" mass="89157" checksum="6B487BD8606B6FE2" modified="2024-05-29" version="1">MTNSTHSPTSTSTNWKKRAEAWNLLLPPSDTLNSCNFLNPNTSIQECIQSTLGIKFDDDNTGQHPFVEYMKRFRDSFKALQGEMRGIEQEQKPEMLNNDNQEIASIENPSDEDSSQKRKVQKISSRERELERKLLESERKSLEEKQLRLMVEVQQEIGEIRRVHDLVQVMLNWCATWGNETLSITKSDSRLTSNKEMSSVDDNDLYATPPKNACQPSIRYVKEDEFLKDLIARSSWGDLEEKYKKSLDNLATSLSDLIDLGEKSATDAHKATNSEGSEERKRQVGHIVTTILGSDFVSNDNANQSFERLQIRGSDQTTVAQPVLHAIIYRVLDIVGLRELYVSKENNTRGGSGNEKDRHVGFLVHEVQEHLSYSLPSIIESLFEVKKCEMVGKKDVKLIELAVKQAIGNSARRMRGEFNFLGIGADCELYGIATSLSKISIVKASLQKVGTKSVEISWSRTKGTDLLSSVGLQLLALAISVSYDLSRVQHSIATLKPKHISKQIDDGSRTVAEMPDFSICEYLGSGAFGIVYKLSATIGDTVKSPQQQSDFFLKIPSCQRASVSLHDEANILERLNSDKPITGKVSNIPSFKLLGSFDINLNDFTGETDGLLLNGIIGTPAHKVKYNKGQLWSVVRKVYATLTAAHERSVYHLDIQPANIIVREVSSSSSSSSSSDNDLDVLVIDWGVAISDDKQILFRGCIPYAHDELLAKARNKSMAKPEYDFASLMYTCYHLDVGFLPWNVVMDEHGKQVCDVGQRRETVLQWWEQKLQEECHHCDEDKFVLNSLQNSISIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBQ7</accession>
    <name>A0AAD2GBQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="3">
        <location>
            <begin position="381"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1967859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="468" mass="50536" checksum="84A2043C79E23D84" modified="2024-05-29" version="1">MMNQILQSITNNNNSNNGNDQSPSFVSILEAYQREKTMNEMIFKSLLSSSLQSQAQQSQAQHSQAQSQAQLQQNQQQHHHQQQGPNYAAILAAANAQNELNQQQQFLQQALLGRPMNNSGLPALMPSSANTVSDSTLLAFLQGNHANGLNALSSSPSAPPPTAQDHANSNPFGQASQQSAADTKLFLSSNKDNKIDLDNFKASSLLPNLKSSNAAILNANGLSSNGSNKDLSTLDTAALLKLLTSVKTGGPTPAPAPSMAAPVAPPAPGDAALLAMIQQVQQHQQQHQQQQQQVQQLQPQAKINITATASSTPRTSSPVNSFLSPVSPNNNTSTANLAMAVEIASSSSNSNNKNTNNSRSNKPLPTKSTASCSFIETQNEDVLFGKGRTKHQGNRHLQKLIENLMAVYEAATKHQKKELADMVVTKILNSGGRFLKLDDDAQRWVEVEREDAHKKVAHAFRNLRRRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC42</accession>
    <name>A0AAD2GC42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002380">
        <property type="protein sequence ID" value="CAJ1968341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="352" mass="39640" checksum="5B8F9A4A75E02AD5" modified="2024-05-29" version="1">MTGQLIESFEVESSASSLRDALLVGVVEDSSSTMRQNSCWHPNHVCWPSILLRARTIGMALAGVMVFMLLFSAFPNRSSSATLNEELQSQASPVALLPPYDDYDDDDEITTPAFLIGDISSSICHLWDNHGDLGLKPFGEEIDRTFCEKQQEEEGYDWLESLKYSEMLRCYNMTYRWCFVNELPEGLDSSILAGSVNSGIADLQSKCVFRFYDHQGILYSTSGQRMPKAFNSKCSHNLISELWHSVNPISGCGIEHRYRFCDNEGNVDWDKLNGPGPFNCREFDAVDVYQMGSADESGMEDLCKAQAKGCAKSIQQACKDGKYHEELLDPMSEECMNFVYFMDYDQICIDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGZ9</accession>
    <name>A0AAD2JGZ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="335" mass="37272" checksum="4949E20C59CA900B" modified="2024-05-29" version="1">MLGSLAIVVRSASAFSTIARNPICRRGRPAFPGRRLQQAMKQQSIYTNQRSFTGIFMSSDDDGDSDSDSKTVESTWNLGGLKKEVSRLTVRCHKKIGKANTRLEKANAEVERLTGDPNVSLEELDKCPNVGEMEQDLDNLRERLTQLNQLEVSIQDIKGKKVVLPEHIAQLAIDLDVRDEGPAPKARPPKKEKGPRVMNSFRLPYRRYYTDNKTEIRVGKQAEDNDELSCSPEHREGANWWMHASGCPGSHVVIRITDQNVDEEVVKDAAALAARQSKCTGNTIKVSMTRARDVKKPPGAKAGLVQLTGSVRTIAVNMKEAQVRLNRLDKTCLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH77</accession>
    <name>A0AAD2JH77_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS11988</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008376">
        <property type="term" value="F:acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="703"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="392"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1949227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="732" mass="82158" checksum="8CD297E4D69AFD12" modified="2024-05-29" version="1">MEPGQGKEVQISSQVLERPWVSSTGSSSSSSVFELEPFGNVHGDKKLSKREKSVIEAIQDRFHTSCPKCKSKLDVYKCSSCSKSAWYSAIANDGTGSVHGYFDGRAKVDTLATTNYKIYDSKFKRLDIVLPISATEEKELDRFCEHLGSTIGTIPKSLPKGRNLAIRLLLTRYGSGIASAPVTELRKLVLDLTRLQPEEVVIVDVPGESTTKYSRANAISLLHQNTCTEADCMIAVVDVGHSVSPSFLYHATEFVHSSHSAYIPIVWSEYNPELVQLELEYYSHQGLKLRDPHDHHRGVWSNHTFQAYAISGADGSKMMMGGTPAELEDGLVSCQRGGLNVVRMKDYGLVQRFNPKDQTKLEPEMGQHLRGLRSQNETAFNAIIGRNRYDGDVFLAVVTSRQNLESRVAAIRESWGQSSNLLPNIHVRYFVGNGTVSESELLRLGGIQDSKQLVVMQEVADDEYPPVRKNVNMLKTINRMVQSPKGPLRDAKIGYIMKVDDDSYVNFDGFLRFLAYHHNSSKAYQFWGDRGFGRKKDREGIRSAGLEKPYCLGGPGYILSKEALAEASRGFDDCVNEISRSPHKKAVWHSDVVISICITKATGIGCFDNDEEYHRNRVFANNYFGDEDFVHRDDLHRVVTMHPFKKPGQMVRQFKRFPRRMIEAAKTDDSSIILRQKDAVVLSDQVYQNIGLPLEAVDSKRNGNVWTLLLLLIFSIGVGANKKRILRKVHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHX0</accession>
    <name>A0AAD2JHX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha,alpha-trehalase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="151"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="245"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 C-terminal" evidence="2">
        <location>
            <begin position="540"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1951262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="72175" checksum="FC16027F5BB59B40" modified="2024-05-29" version="1">MRQETDQTILKPIKEIETDQTILKPIKEIESXXXXTSIIKSSMESLCITPTLLLVFLVVSTISIFSLAEAQDVDRGRFHVIQPSQYAHLLKGDYPWAIKNVPFIDFPENDDILNTYYYRWRMYRKHIEYIDEEDIYVVTEFLPQVSWSGLYNTIPAAAGHHIMEGRWIHNERILNDYIQFWFTKAIPVAYTNWIGHAAWQRYLLNRNATFVKSIQDGLDHTFQEYYISKYLKEITSNNNTVNQCWWQDDGRDAMEVSISGSGCRPTIAAAMYGEAETIVKLARMEPLNRTLELDYMKWQELSRSIILDHHWNQKLQSFAVIPTVPEMKGSEKHEVPDGVASDCDLSNVRQLNKTVDVRELLAFMPWYFDTLIPEEQVSKFLPMWKELFDPDGFDALYGLRSAELRHPCYNYSYDHGDCWNGPSWPYETSRVLTGFANLLNRDIIRDKTTHKFPSVSPEKYWHLLKQYARQHTRTYAVNDTANPIGSGHVFENLHPDLGYWNNRQRMYESNDDNKNMGDDYNHSTFVDLILSGLFGIRPQEDGSMEVSPLLPSAVSAFAVDNVLWQGKFILSVIWDKTGTAYDRGQGLSVLLDGKTVAHSRTMKRIVLYPEDLKQGQGEGQSSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIF9</accession>
    <name>A0AAD2JIF9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="481" mass="54477" checksum="9040D18320B679F0" modified="2024-05-29" version="1">MEIAEYVFHFNDKSALDNQSIETSIKVYNHFWQSFEKNPLVKEFLSKDLFDILESYLLVSFYPAYGAAVLYQNNNSLQVFVRTIGLDGWKKRIPSSSHGREQHAVPNLEESAIMDQGPISRCAVVAIGNTLAKSLRESETNNRGDRRRKSNDHEGNQKTPSFLNEKLGQSIKKVISGSEVTIGEQSAYGGTTDVGMHTGAKKKNTAAPLAFATASTMLRLAGRPQHEFKALMAAYLISFLDVLPKLATYDARAMDRYVIVMREAKPFIEGLRNKAFQQKILHKMRTHHEQLYSVSYGPPQQLNLCGVSETVEDLFPPEFPMEPWTPQIQENETKVDRFRGEAEKNLLWVDMESTAFSGHRSEAWVQLHSLNLKFWNAASSLKYDYTTENVALLKKDLDRLSIIVEVAMAATDEGRYTMSVVIRSYELLAAIICFCCAHVEMEGNHEWFKKYTPAFNPKNLHHLVLDDNRAVDGCSSTTISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIS8</accession>
    <name>A0AAD2JIS8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS13999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000073">
        <property type="entry name" value="High mobility group protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF15">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="113"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="212"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="113"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="212"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1953376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="325" mass="37227" checksum="7DC6C3C320D3105D" modified="2024-05-29" version="1">MAKKPGRDPSAPKRNMSAYLLYQNSMRAQFKAMNPGMTFGQLAKYTSAMYSDISPSEKEAWVARAEADKSRYLQQLSSYIPPPGYDEKGDAIVSSMYTRPGRKGKPERDPNAPKRNLSAYLLYQNAMRNQFKRENPGMTFGQLAKYTSHMYKNLTPDEKATWEARAEQDKARFEAEMAVYVPPPGHDARGVLIMDQVPKKRTKRGPRDPAAPKRASGAYVFFTNEMRPQVLKEYPGIRFVELGKVMGERWRALAPEEKRRFEDMASEDKLRFQVQMQDYQANQEAAQPPPPPSPPPIPVSYDQMHYAPPQAHHFYDPYAAHYHHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKF1</accession>
    <name>A0AAD2JKF1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="221"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="329"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="456" mass="52457" checksum="0AEBC67914811C75" modified="2024-05-29" version="1">MDFEIKQLITDFLEWQVTNHGKGEGVLAAWKEVFAPKDNNGSVTHPSSRTIQYVAMRKSKQMKSVALFFDKSDVVACIPTIRDSEETDSICVNKEFSSLFQALTYMATMNSSELTTGRIKANEIGASNEFSNSKDTMTTLAQVDKDDKCSNNNNNNNKRDLQGSSANGHVDTLEPSSKRLKTEGNDVMESMNPETPEKDSSEPDGNKKPSQFTKIRFKEKERQWQGKFEALASLWKNGATIYQRDIAPFNGLSNWVKHQRKRFKQNTLREDRKKKLDSIGFKWVGRNTIVLSTEPNNEKELAAMKHAYLTYESQQKQGLDVEKEDGWEILWKQRYQELVEFKKRFGHTKVPKEWPENKQLAGWVRKQREQSRRPPEESMLTESRKQRLNDIGFAWFLRPSRLKRPPPPDLTPKPDPKPEMAPEPEEPAGQTCIMGKEDESHDVEPYSVDKNGYLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMK2</accession>
    <name>A0AAD2JMK2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMK2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042151352" description="VWFD domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="2">
        <location>
            <begin position="310"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="567" mass="62969" checksum="FD2D3ACAE895D3D7" modified="2024-05-29" version="1">MIKYNLLLCLCLIIGSAPIADGAPFDYQAPATGSAKCALINIIMDESASMDGDQLFMKTTALPRMAHTLYSSAYGYNNVFLCSSGFGHGSNKDDAALNTARWRSHGCTTYNGHGVAHNTAVTDWESSGQVEDGWYSMQMGMEDVPDVIEGIDLLSHCGRIDKNMILVTDEDRDDRDSTQTASGLKNLIKSNGYVLNVIADVEIDNDLDNIGMKIQNGGYNNTIYTADSSAPLKYVTTVDTRSYKIFADGFKDTNTHYSDLVVDTWGAVFNIESMRTQGEVFADVFVTIKVEEISEGSGGSSGGCGSRCESNSEVGGDPHFTTWTNEHYEYHGQCDLVMLSDPKFADNLGLDIHIRTKIVRFWSYIKSVVIRIGNDLLEIEGTLDDNDAEAHYWINYEYQGDLDDFAGFTVTQALPANYKRQYKIDLSPKYQDAYIVVQLYKEFVRVQFHGGEEVFGNTVGLLGDYNTGKTLARDGSTVMNDFVELGDEWQVLPSEPKLFHEITHPQFPEKCIQPEDPRGERRRRLDESTVSIEQAEAACATLKDPLTIKDCVYDILATQDLDMVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMK9</accession>
    <name>A0AAD2JMK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMK9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042225640" evidence="1">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="263" mass="29114" checksum="1978476D3CAD24D9" modified="2024-05-29" version="1">MATAFQLFLITFLGMLSDSDGFHGYYCLPHHYHRSTTSRRWALHAGADAIVPPTVWIQDAEEDFVDEDENLEDGEICLKSVKAFASPVLVEDVVPRFLSAGALVQRPTIVEDIRSVCDAWTADAILEEGGPNLQLQGASLVLDDLFQFHLEQQPADPIGALQTFVVQCGSIENETSCASYMAANSRGFRPLKDLVRESSIYTKSAYLDGSLDGMVLEINKARVAYGRLIEMGCPNHGTISKILQLLPDDDLIQRFTIKRFSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNP3</accession>
    <name>A0AAD2JNP3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNP3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="181" mass="20499" checksum="5F5D6674DF512217" modified="2024-05-29" version="1">MQFSRLATLALISVPYVGIGALIRYYKKTDGISLDDEMEITPLQRKAMWVHLGYFAMVPIMIEAFQDLPGLDVVIGSRSTEPSNISYMMICLASENFFVSCTCLGMLLTQTKVPRWAMMTPISQLAWNLKNHVAWYFMSGTFAPEGPLLFALLDMAVIWPITAVYGYNFLYADKKDLNKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNT0</accession>
    <name>A0AAD2JNT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxin-14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46713">
        <property type="entry name" value="F13M7.16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46713:SF5">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PUB" evidence="3">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="61396" checksum="6BD658983E502227" modified="2024-05-29" version="1">MNSEMDSDREEPPLPQPMEEESEANIETAIRFWNHPSLANISSADKRSYLHAKGVSDAEIHKAWERIVERDIPNNAGGTNAITTTVPVAPIVAQGQGAQGALDSAAARQTPNLHTPGQMSYPPASNNYVQPTPTPYYNNNNNQYPPAPQEMEEEGPLTLMQGASLVTFGGFIGLTAAAASRWLNGGDFEILPGPKYPADIGEQRSQFLKRLEEEAEEEEEDDDDDDEEDVEEDGVDQEIVAALSQQKLIQQVESIAESLRVNTAVQEKLLNKLTSTGTSITDETMGFLRSTDSSKSKETKTEYDKSDVQMIWKELVQIQAELRSLNSAMKGKKSEKRVESTLNNLDVCIEGITKKMLSSAGDSTPEPSMAKPSGEDPQPQPPQDASTVSVEEIGKALEELQMQNETATTSQSILDAIRTVAEKNDAKARQVGCQLLLLYVANLSGNPNNPRYRKIYTSNESFKKVDQLIGGKDLLMAVGFEESGNYLEWFPNGPPAQESSAIEVLKKATEALRILKSGEKSDDLTNSALAVFPLNTTASENTEQPSSNETAVPDSAVPDTVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUI4</accession>
    <name>A0AAD2PUI4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUI4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="484" mass="56088" checksum="5E2CFC0D0F6CF7E3" modified="2024-05-29" version="1">MKSHPCLSNCFAWFIISAIVTALIGFNSDEGFLSIDYDNHRILSEQSPERKLRILYTVTTLAEYDGGSRSTTKGSDRMQNVLIPVVKESVDSMLSHGFEVDVFIVAFYKMTRFELIRNALPPSVKISIWDEAAPLSYKGDEHMKPNAKLHHNTIGLARQHRFVVKDHLFEYDFFCNWEDDMVIHGDHIENYLDMTKELYRLRELAPDDKLDNRQGSNNFFGPLNKEQLKRTLPGFIRVEALLDEETYGTQPELDPVPVKERPEIDPKPCCHLRNESFASPTRPAAPLSNKLFMWEVGIKAVGIRHMPDESNLGWVLLQRGPSRGKDVVDDHTMSDYWSNQLNKYFKERRPSSISFHGINNQGGWMGTQRQIWEWHTEVCPGGFLPPYEAPHYRFDGLDMRNVEWWSGGISLVTARHACNMQRLISLEPSRFARHLLYHSANNKQRQLQFKKKTFVKVNDFYAQLLTVQNDATKDMNKLKRMKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUL5</accession>
    <name>A0AAD2PUL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="75" mass="8066" checksum="8B112174BB540D6B" modified="2024-05-29" version="1">MSSNEIVSEPEYLRSVGTFDSLSTEVNPKDSQDDESPVKKVLGRIQEGAAAIFSCGKAGDVDDKQEKVKSSTESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW65</accession>
    <name>A0AAD2PW65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001988">
        <property type="protein sequence ID" value="CAJ1959282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW65"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="314"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="951"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="972" mass="107506" checksum="490D6190D5E1E890" modified="2024-05-29" version="1">MMNHQHDVERIEDEGSGFISDSKVAKEEKMALAPKSDFDTGTARRTDPCNPSRYPTTPASAQYPHGEINDPCHPPPITDHMPWPDAIANPTPSPPYPQQPSHLLHFFETQMRDHAAAFANAAAGAAWVSAQIAADMASASTTTNAMHYPVAPQFLPRPPYMFQNVPMMQPYLVPQNSPTQFVGFDGQLQPENNFYGIHEDDAFENSSSSECMHRRRKRQQCGPPSAIPSSSSENASLSYLSPVTGPSGRRRRRARNNRSSHSESQPSCHNTRSRRRNRRVALTSSGSDGGNAYNITKKKQRQPEPDNSSLLGKTGVAALYVFCEKRRTTPHFKLKDRSDERIGPTVGGEDFEIVVSVDGRVFGHGQGKNKSGAKQEAARLALQTLLPGVEFDKASGILINLPEASVSRKSVQNLWSQREAATTAEELAPNLAKLLAIGRENERDDQASWVATADAEKTHGLHRRKNMYPETSTTSEEENEDTYYASRGASVCSALLHAMVQIDEKIPEPPVYTYHVSAVGPPLRHKHHLKRKAGGPLCTTSVIHRGSFNCTGTMSVEISNPDPGKPSFDILQAIGIGGTKREARHRAAAKLLAMLFPECEGMVAVKQAAEAFREKYAADKALKQQSKRHRPYVDISCSSRQTLIPYSDLKTEGQRGYQFALATNGPAFSAAGDHILCALQCTTQKDELNAFFSVGPSQSRQQSRQEQLDSAVSLALQKLNEHDEDGRTLPDELTVDDVGRTVLRRSTLADVHWIMNLIEGDGQLLSLFSPLRRKLNSPKRTAVESGEINISLLRHWLSSSVVLLLCRAIAPFEDPPLGCAALTMGFSMEKGCSLQITQIASKSHLPRERFIEVLQSFSQEMSSILEFPKQTRSAAATKIRRNDIEDIIQSHLLIPERPTNARRQKKSVCQVLKKTVSQVSKQDEQEHLLSTRLQSVQEEIEDCGDCSGLEFASEKRNSKQGQVKSSKRSRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX13</accession>
    <name>A0AAD2PX13_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX13"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042254769" evidence="2">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="174" mass="19767" checksum="6BC92124D808AA40" modified="2024-05-29" version="1">MKYSSISYSLFLILLGLLLSQESTVQGFQPATSSSSSSLSFSQGNQLLALTNDKTASIALHASLIDPEQEPEKASNNNSPTISTNNATWKKICDINEKFWDYTVNFFYIFMTVGILMNLSGFAYKVDLEEGFTVQTVNERRQELQWQKEIQRYDQQAAMKQKSLLEKVEMTNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBU5</accession>
    <name>A0AAD2CBU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="3">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CYCCA115_LOCUS1031</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000510">
        <property type="entry name" value="Phosphatidylinositol 3,5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="18">
        <location>
            <begin position="296"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="20">
        <location>
            <begin position="1496"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="19">
        <location>
            <begin position="2037"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="89"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="340"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="413"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="470"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1032"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1283"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1474"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1724"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1204"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1037"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1283"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1477"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1724"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1741"/>
            <end position="1763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAJ1923469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2212" mass="247687" checksum="488B2528A04348E5" modified="2024-05-29" version="1">MLTNVFQNHMTKSGSNPTGTAGRLPPKGPKQIEQGKTEQQLEDEIADEMFVQFPVYGSQSPANLNPTADWLLGGTSNIPNQQQLLLEKEKEKKQQEQEKQQVPPMDNKPANSTTLSPTTANTEKYKGWDEHEQDLWRSQKQPKGNVQSSAASRARGRDKYLRGRPSESKDDFSQDWMMAYYYHTGVKPKLDIKANSIKKPTRQRQMSPFSTNMNATASANTPSITSAMTTSVTRQPGAPTIPEQDETASIKTSDTASMYRTVTTAATSAVDTDGSFDEEEDAIAEADDDRQHWMPDHYAKQCYACDTQFTVFRRRHHCRICGQVFCNVCSGYFVPATSNQELPQQNNHNNAPGQPGSLQQPQQRTQSTPVPSTPTVVGSPVIASSKNLLRTCKMCHDQVAAKQLAQNKVIQQQAEVPRQKAPQTQQSKMKTPQRPSLQAELETGDSVLKDLSKKRTESAYAKRRLLSQQKAMEEEEKEQTSLLLQGQKEEEDRQLYHEKASSRGVFMSSPRHEERKNAQGIAIQDSSDDDRQTAVKEGNRQLGLSAATHLEQLAEALLASDAPLLWNQLTKDSRDLGDTKLHKRWVNKLMHLATKCCTTVQPNVKKGDLLDIRPYVKTKVIPGGSYKDCAYISGIMFRKTVSHKQMARDVDQPRIMLLSGGIEFTRTENRIASLDSLLVGENKYMEILVGKILKLKPDVLLVGKAVSRRAQELLLKARVVLVQHVKASLLKRISRQTGATIISSTDHIMNKFGAHVLGKCHRFRTVVARDNEVWVDKLEITYGTKSEKREVQNLLMNPDLPNHKRQEALAANMLGENVMDGSDAIQSGLAKRGVAQTYVMMEGCPKHLGCTVILRGADREALKQVKKVFRFLVNVAYNLHLETTFLKERCACLRPDFAVQPENLCSSSLCVDYGSPPNPRKARPWNGGPNNEGAQRSITGGISVFDHQSILVSSVWMTSKTQCCPAEVKGICYYSVQDVSLGQFLRDSCFNLSLKCQNSNCKKSVLDHSLSFVHNDGFINITVDYMDEPLPPASLDSSRHRNETTRKDANSGDDEDSPIATWTYCKQCGEVVTPLVYISDKTWNYSFGKFLESFFYNGDTIMNPKQHKCSCSVQTETNLFFGCGRLSARFTYERLKPFNVFVRKSLPLDISYHRTDALRQLDLISKASSSLFVNFDEHINKVSREAMALFGTSTSRPEHMDTVLSELQKIASEVDNAAKTLQEKIASVSDKCTNEDEEVISDALFRFPWFARRYLYMLTSAWNEKLSAAGQAIVAMKKISSSASNRNDSMSSNVPLGASDQNDELHEGMRRLRQLREVYSSYNITDITTVIPTIPGTGNEKAQIEYDDDFDDHDAAVGDFSETVDADVLASRRRLQTEEKSKAKGSAETIPNTTITAKVTPGGAVKSAITRFFNRGGDESDPYIVDLGIFNEGRPRLEPGVNGIIIPVVDEQFSTSIAYSLSSKEYARQFDEFSKAEPTTSEPSTTPTVSAEHGTLSTGQQDLPPTGRNAFKESKTSGSTSSRDKEGIERRILVRNKSHVKHTFRDFDEKGNNLCKFVVTTYWATQFHAVREAFLTPSGSKNDSFVYPPGMNVEQGYVQSLTASYSWAASGGKSGASFSRTADDRFVIKHISKTELQMFLECAPAYFEYLSKVFFHGLPTVLCKVVGVYTISFHNRVTGKRSMEQVAVMQNIFCNKKITKTFDLKGSLRGRFAALIQKAKYSSSNAGSTSFSESASAKGKGTGDKGSENEARTNEGEDTEKPIRSGRTLLDGDFLEFTAGRPMPMNDRAKAVFHMSILNDTLFLSIINVLDYSILVGIDEENNELVVGIIDFMRQYDILKQMERVGKSLPMVVGSEAPTIIQPPLYKARFTNAMERYFMTVPIDQSLLYHQKQTNCLTRTMCTPDSERDSYDERPLVDDLLDKHAKAIASVRESILADDECKELYEKGDNTKRYDDIWILRYVLSHKGHTKAASKAAKSTILFREEHGMNELGDLRPRMKQHGVPDSEAMAKMEPLPGYELFEKYCSENAVCLTLPDENRGLIMYCDVGALDQHGITENIDESVIREIMLYTNEAIFQILDDVTRRTGRLTKVTKIIDMGNTTLRGMSRTYLKRDAACSKSLEDYYPQLLAGMLIFNGPTWVSMLWAAMKPFFPKRVAEKVDFLPSVSKLKGNKKALKPFLKHVAEENLPEKYGGLNKEWPLPCVAERYITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDX8</accession>
    <name>A0AAD2CDX8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1898934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDX8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1898934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="475" mass="53601" checksum="B0B59809A4A28718" modified="2024-05-29" version="1">MDMDFHLPPRLVHQVLLTDPSELESLAPGLKSRTTTFSEFQENLSQDNSNPAHVMKRAYLQNVQRQIDDTLDLHPLHNLLLELHKAIRALVPNRPDLHSFLKDDIELPEPEDAIKFLPFIIKAAQALAKLESEARSQSTIDWLKVANSETAPTKKTIDFMIASIFYLIDKAELCSKDKQDFYLTEVFAPRIRNTQEGLSMERKTFYSKFGKDQVPPITKKWVQGLVDSSTADVSIEDLQNSSKHRRDLIKRGWIDDILFQREKEVILPEVFFMDLQHLQAIRNTTRIAAAGCALGYFACIAAKVDPEVLLQDGDKGVALVKVMNNKVHPSIESYEQSVEDCVVSLAKEWAPLGNTIDPQALETLKNQTRSVLKGQSPVLKLLDNRMRDIVSNLVIHEFEKDIPKQLQTGIGSVESKSKESVLVMKGKKVFQERGLAFYAVELALATELAAKVANLACDLYMAEILDRLILDSLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEJ1</accession>
    <name>A0AAD2CEJ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000058">
        <property type="protein sequence ID" value="CAJ1928740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEJ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1928740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="302" mass="34871" checksum="8F03C17864FA5CA7" modified="2024-05-29" version="1">MAFRRSIISLVKNNQISAFRTSLIDEASSSTIRLIHTHNSNIRAELFKLPRRIILIRHGESLGNVDDTSYASIPDWKIPLTRRGERQAAHAGEELHNLIKGERLFTYCSPYKRTIETWDIMKESLKEKDDVTLVGTREEPRIAEQQFGNFQNPKKVRTAKVERRTFGRFFFRFPNGEAGLDVYNRASSFLATLSRDLQWLEANSVPMEDLNILIVTHGLTLRLLLMRYFQLTVDEFENSYNSQNAKLVIMDRLVREDNSEFFRLDDTSTEALNLKGEVSSEKPVYWRGSALDVDPYNDASDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFE3</accession>
    <name>A0AAD2CFE3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFE3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="117" mass="13293" checksum="A33D29C88B366043" modified="2024-05-29" version="1">MSNKTEEEESTRSQKRDAIETDGSPISSSESSDTMPGVEGRILKKQKKLPEDDPVVVARKALEMFKEIEAEDAPHTIDSKENLEIKSETKIERLDSPRGPKIHYRLPIISQQEEFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFT4</accession>
    <name>A0AAD2CFT4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS39</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1889905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFT4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23539:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23539">
        <property type="entry name" value="MFS TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="258"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1889905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="474" mass="50944" checksum="12F7CA2AE8D3FB9B" modified="2024-05-29" version="1">MSSDLEKKEKTEKTKSILRWAALFLGELRDGLTMINMQSAFLIVAKEYHETQVGVLFFVFGMSQFLFQTPAGYLYDYTENKVLWLSMAGIATTTMTVLTAIFATQDNFLLMVFIKFLQGGITSFIPPGLNSITQGIVGSSGMTGQVAVNEMMNHLGTAIIVGVGSIIAYSLYPNIGVLFIVSPIACLFFVYFLNQIKSEDIDHDAARGLVAEVSDEAANAKTTSQVEPSYAFGDAATTHNADGTQKATSPLQLLRDPILLLFIVICFLFHLSNGTVLPLVMQTLAIGNGKNGILLSGMCITIAQLVMVASAKTCGTYSEKYGRKGLFLVGLGIVPIRCAILAGLLAIKGDSDAGFFLQTVILSTQILDGVGAGLFGTMYILVTSDISGGTGRFGLTLGMTTAAMSIGGTVSGFLGQYLAQYYGYLSAYVILMIMSLVPTLVYLIFMPETLPEKQKIESGQGGEVQPKSDYMEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG05</accession>
    <name>A0AAD2CG05_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1894937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1894937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="264" mass="29237" checksum="D740DA57BC925180" modified="2024-05-29" version="1">MSSEEGSHQQEGSNDPPATITNDEAAAVDPNPLMEVQAAMESMQLSSSRKEDDVTDENDGWEAAPTKNSKKRRNKRNQNSSPQWSSPPIMVEPIPPTPQTTNFSPFMILLIGLPGSGKSTFSNLLVEAMPYKFARINQDQLGTRQKCIKAANEALDDNKCIILDRCNFDSAQRSTWFDLAKKRKIPVYGLALQVPKLLCIQRCQGRGNHETVAAKDAAKVVNIVARGFQLPSKEEQQGKFRSYLTLLNSSMLDDAVIHFLNQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJM4</accession>
    <name>A0AAD2CJM4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS5025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000546">
        <property type="protein sequence ID" value="CAJ1936075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1936075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="99732" checksum="F11842F7EAFDA28C" modified="2024-05-29" version="1">MGRDLSSQQSPSCFSQIMKRKRSLISSFVMICAALYFCQMKHAVGLLDEVIESRILAEIDLKKEFTQQKTVSSLSTHPAREEIFWDRNRRIAESLLARNDDKGLPRKIITAYLEAPMNDTIPGTGDQGDPKREIDKGTPPEFYEPLPLRQNTPEDLKKYEYPRFRTCHDLPAKLPVDRGLQFDKLGNVVVHNVGNTPTPDDYPWQEAPYCPVDADPFLPWIHDIFPSLDGTRVEFVAQNKRRCKSGSAYQKDILRMTPQVALLQSVSVEVIDEGKARTLAPELWSESDKDATFYPPMPRYRLAPYEEASPEGMWTRFICRFHTTDFQSGKPKILKETLSEYPINYELAGYRKNRPQLLTPKGRETNLFWTSTLLFSCPIPPELQPLVLDGSTILSDGTPTLHVDVVPIRTSPRYGSKEVYFTEDMVGPRARWETSGKLDTFNNSGITSNGFNATQRWGKNHVVPPVEASGRWANLPICAPPTIPLEEKTIDVADNVKDDMNKNEIASKEAMMPLQKEKPHQLTACLWSAASFSERGIKDVRNKQKDTVERLREWIEFHLLVGFDHIVVYDNSGAHTNETSLEPITSQYPPSKVTRVDWPSLCCNNNVPGHPNTGERSSQYAAENSCRSRYGPYTEWMASFDTDEYLVPMGNYTNLKDVVKDAAKGGTNILTFRSTRGKLRHDFTREAEYHEKARDDSTKIQILDKAANVTFLEAYNCDSSPLPKPKYADRAKKQIYRTDYVLNHFVHYATVTKPYMEQYRATKSQGKRWQRILRENAPSERVTDEIHEAVMVHTKIVTWKNTRDTNIRCHKTARADRAWRAKGCYIGFPSPNGTATFGRPADDGMVYNCFINEKVENYWLPQLKERLERWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK23</accession>
    <name>A0AAD2CK23_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate/glutamate/uridylate kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS5265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK23"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010167">
        <property type="entry name" value="NH2A_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602:SF12">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE NAGS1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042144031" description="Aspartate/glutamate/uridylate kinase domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="5">
        <location>
            <begin position="145"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1936585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="482" mass="53119" checksum="CC228BD429EEFCBA" modified="2024-05-29" version="1">MLSTSIIQRLVLVASAVISVDAFMSSNQMRSFSKRVSGMNGIADHIDDVASEIKFFNDTVIGRNYVLEDYVNGPAMNPPKFDVSKLEFVSTCGADDPDESCSVNELYSDMIEEHKTGEEDDESYPYVDMIRGSAPYIANHRGELAVIHVPGDLLSGFDLSDFMNDITLCWLLGMKIVVVVGCRKQVEERLNSMGQESAISGHTRITSKEHMRIVEEEAGFARFEVERRLHRSLRCSQLSAQTGNVVSGNFFKASRFGIVNGVDFESTGRPKQLNVKRILDYLKSGEIVLMTSVGIDLAGDVLNVNSEALAAFTAASLCANKLVYCSNTGMVLRNKETKMTVQNFRSKDAKKILEHFNMDIRKDYFMSHVDTEGLAGGASEMLVKIGWACKAIRDGVDRAHIIAPSNGALIEELFTAKQGTGTCISEDTFESVHPDDDSGDFVSANEFAVNLSNGVQSDDDPDWPADVPKDTFPWQARADTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM88</accession>
    <name>A0AAD2CM88_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="614" mass="66417" checksum="C82F5A8B53C96980" modified="2024-05-29" version="1">MPSQWYSNQGPSAAHAHPQHPMNPSHYGRMYYGAPGAPGAPENGQQNQPYHNRSSPPILHPAPSNSSAPTSAAPGPVSGNAANNHAPIQSMSSSGAGMPQPHFQHHGVHPNGHYSLPGSAAAPNAHLIRPVPRGPGPVMQHSYHMTHHDGAGHPQRVPGHGGLPHQNMANFPPVPSNFHYGANHHHMGRVQNHVHHLGPHHGYASMGNAGSAGPYYQGGHIRDNSMHHNMPHHHPMHGQLHHADHQFQRVARNFESPMNTSIDHSAIRQSPSPPPAPPSTSTSDPSNNNSPAMVERVVSVDSTSPSAPAPNTDALKEQTNQADKTKERTSKEKVKQTEDFTADAASILLQLGAMVKKPESPRGNNKTMENDSNDSLNDPIATVTPVNEGPLTIEPTTSCDATAEDSTPGITSKPSHDSVDSAVSTESDFPAPIPENYPRRLALPQDDSKLNSLHCFLRSDLLDIFVVQKSQNKSPTHSPGSSVGRVGLRCVHCAMTRKSRDDRDEAPMAVFYPKSIAEIYRLVTSWQRCHLRKCRNLPPGLRSQWQALRESDKSRGKTHYWVTSAKQIGLVDCYSRAGGIRFDPAVVDAFNKKQCQPVAPKDTAATLAVAAVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM98</accession>
    <name>A0AAD2CM98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">2.4.2.10</ecNumber>
            <ecNumber evidence="8">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">OMP decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CYCCA115_LOCUS5554</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="7"/>
    <dbReference type="EC" id="4.1.1.23" evidence="8"/>
    <dbReference type="EMBL" id="CAKOGP040000613">
        <property type="protein sequence ID" value="CAJ1937195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375:SF1">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAJ1937195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="54040" checksum="819B230FF32D90B8" modified="2024-05-29" version="1">MTSFFAKLEARVNDVDSLLCVGLDPHSKDIGSDDVKTPEDKCAAAFTFCKTIIDATLPYAACYKPNAAFFEALGSQGETTLERVLKEIPSNVPILLDVKRGDIGSTATAYAEACYEHLKADAVTLSPLMGWDSVAPFVTESYAHKGAFLLCKTSNPGSNDILALNLANGEKLYERIAKLAHDWSTSSGASLGLVVGATDSVALANARKAAGEKAWILAPGVGAQGGDLEAALRAGMNSNGTAMLIPVSRGISRAEDRAAAAKELMVKINETRKKLKSEEGSSSGDAIQPYQKEFLEFSLSQGVLKFGSFVLKSGRTSPYFFNAGLFASGAALDKLGRSYASAIMAAPQLVDGKGGVAFDVLFGPAYKGISLGAVTAAALYRDYGIDVGYAYNRKEAKDHGEGGQLVGAGMTGKRVLVIDDVITAGTAIRESHEMLTTIGAKMVGVVIALDRAEKRSLEDPVSAVQAVERDLSVSVTSIVNLQQLQLFLEKSPDYGNDVLATVKEYRSKFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN67</accession>
    <name>A0AAD2CN67_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS1920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN67"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1930377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="626" mass="67805" checksum="36389FCE008CCD59" modified="2024-05-29" version="1">MPTLVEETNSGPDMAPVVADPSELTLTVGGVTFSLTPSDNDAGLSYKRNGHEVLLSLSSFTGSIKVSLKGEVITAADSPKYKQPTATVEVESPVFPSGPKSKRGKASQTKLSFVKTTSTTKKTNKESKRTVELVTPSASAKKSRKAINHEPPNLGQTEKPTQEATQTQPDLSQTMSSQADDAAMSNPLMQQERTQSSGHSDVQSSTSVRDILDRVNNSNDDDSVATVPMEDDDDSVFAENSPQETTQAESETKMDDDKISTEAKESIAESPSAIPRVHPSPSPRWGHSMTKINGEKVLIYGGQSFDLEGNPVMLDDVHVYDMTNGSWNKPIQCRGDMRQWHSSTYLPERQLLITFGGETMDPIKKNKVITSNSLKCLDTDIMLWYPPAVSGDIPTGRSGHTATLLPNTNELVLIGGVKGARWLNTVSVLDTVRWVWTAPKVEGLAPKPRSYHSTTAVKGKGDTYKLVVFGGNNKTSCFNSVHVLESSEQNVWKWSNPVCAGKAPFPRTGHSATLLDDGKTICFYGGWDPNEEDTNGGEDNIFKGSFLLDTSTWTWSKGPKASPGGSGSEFFVEDCGPKRCGHEAALNAQTGEVMVFGGRIPGEILAGDYQRLPTSSSEQMVDMDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN78</accession>
    <name>A0AAD2CN78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS5357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042294520" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="164"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1936768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="269" mass="29442" checksum="45AA0C88C7EAC085" modified="2024-05-29" version="1">MTTRLRTSLSLFLFAVSASGSLAFAPSINNAPQFVRQESKSSCLYISPLASKDYLTEDGGVQKEILFEGKGGIPAKGTSVIMSYAGSLAPNNWSSQEVVDCWLSEQQGLDHLKDAFLDSEIDEAKLTNPDEFTEDFVTNTLDVQAKIQCKKLVLAAKRLASNRGELPYGHMFDSNPEYSYKLGSNKLIKGMEIGLATMKPGEWSVISIRSDYGYGSEGYRKANGDVIVPPFATLNFEVQLYPEGITDLKGLEEYLGGGDEAFDIDINDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNG3</accession>
    <name>A0AAD2CNG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNG3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="355" mass="39066" checksum="30F173648A9254E6" modified="2024-05-29" version="1">MKLALPQVYLGTMTFGWSSQTSKIVDDSIALEMVNRFITSNEQMGINSHLIDTARVYAGGNTEPMVGRAISGAKSESGKIVLGTKAHPSVTPGLSPKGVRSQLETSLEEMKVPSVCEYYLHQPDTENSLLDSLKCANDLIKEGKIEKIGMSNYHATEVARAFQLCQEHNLTPPSVYQGLYNPLNRLVEEELLPLLKENGCSFVAYNPLAAGLLSGKHKGTTDFVAGRFLNNQNYIPRFYTEANFQAVELIKAQCEKDSLSMVEATYRWILRHSALGEKDGLLIGASSMEQLDQNLQACKAASESDDLSPELLGVFDECWEITAPGAFPYWRSYSSDMPNREALDQGASYSAAKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQC7</accession>
    <name>A0AAD2CQC7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000822">
        <property type="protein sequence ID" value="CAJ1939629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQC7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="17053" checksum="27C9E9739B279CBB" modified="2024-05-29" version="1">MDVSITRQMVTDQAHHKEIITAMVALGGEFLMRAATRDGEPDNEAYEKWSKQQIAKTKFQALEQALMATYVGLQQGMETPNQQLAKLNMIRYEGRTMMYDDVQQRGYVIWQNRHDSKRVQPRESPTNQPIGLGRRSIPSLHTRNQGCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRP9</accession>
    <name>A0AAD2CRP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS8801</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042154126" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="11">
        <location>
            <begin position="28"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="610"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="888"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1944265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="911" mass="100716" checksum="0E6910D6DDF6CBC5" modified="2024-05-29" version="1">MTLSRPTCSYLLISFVAIAKCFSASDAQILNTFEEFHSLRNGATDITRVQSIDVVKAADESTTPICNLAMMMPFFDLRPGRIRLLENGVFQAMAAVMLAIEHLNTGNGTLVAEVEGLDQRCPIKFNLESFDSGLYEVETVNHVITLVSRQPGIERVPCAFLGAARSAVSIPSATISSLKGFPQISPISTSSKLDNPRSFPLFGRTIPSDSGTSVPAILYLRNKLGVKNLVIMYVTDAYGDAYAQGLRKAAEKYAPDMKIQTVEFPFEITPEIVTRTVKRVKETKYHYVFSIMFSTAHYDAFMTEAYDQGIAGDGDHFWMFSDSVSTSIFERTFEIGSPLHLASKGCSRISAVAGIEGDERYDAFIQSMADLNNPNDIALLQSVHPQPPEGFDPIQIADDTQTFFAKTNAAVVAFIYDATIALGLSACQAGGQNEAFFDGQQLYDEFLKCDFLGVTGNNTYDQVTGTRVTESARFSLLNVVEEEPEIEGENTVRLKAVVSDAFPNGSWEEVVPIRFNDGSTIPPPDLPPVEMDMNYIGWALRLTGWLSAVFIFISTIYLAMWTYKNRNKSVVLQTQPIFLYLICAGCFIMGIGIFGAGIDDEIASPAVCNVVCAMSPWFFCIGWVLAFSALYGKTACINRFFHYPVPELKIKIQKIDLFAPALGLMTIVTITLLAWTARAPPDFKRTIYEWNSFGQPTKSRGLCAYDGAVPYAIAIGFVFLISVEIAIRRAYEARKVAVEFAETEYIVLTLVTICGIAMFFILLWFLLDHDPAARFVVIAALIFLVSMSMLLLIFIPKIRFKTQVKRQTKENTAFGGSEGRINMQHGGANVAITGLDFSTNNGQSTIDDDPDAAEPTKRESAGMIVLAHPKEVDMLKGEFKSLKKEYDELRRNKSNRPATKSERSLDSNKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRQ8</accession>
    <name>A0AAD2CRQ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS7413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRQ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1941221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="746" mass="84683" checksum="060233432E244A0A" modified="2024-05-29" version="1">MITYGGGAFGFEVLFRLHGSAIWKSLTLAVLSCGIYLLLYFYSGVPENYVADATDPNKVVLFDHPYPIGALVSAFSFLLVFRANFAYHRYWEAFSAIHLMHSKWTDFATEVASFHYQSERYSKYAPPAFGTYEPIASPFVLNWSDPENIGTPAASMAASVFSGAPSQHMMAVSRERERLDEPMTKEELELHLEEMADQATINGDASVTSTLRSRFFRRKVNFQDEPPPEEEPPLHKTKKKTKKKKSKPEREYSPRSNYHMPKGTSERTKMINQRNNSKNINNCLANDDDDYDDCFGGVNNNQRSRSKNKLFGLDKKTQKNKRQPSLYNEYGANTTTFTTVARRTWRKGVQLAPPPEEEWGNNNNNNNDDEPPKPPPIMSIPPNALFLEEIAHLLSLLSAVAMSTLRNDLEEAESPLIEFFPNEPWPHVDPDDYMADVRQEWESSSSLITGWNIGLPSSIRYMLGLSRNDVSRTLYNAARPFRVIGNVSDAEIELLQKARGPLAKVSLCSLWLQEFLSREYLQGSTGNIAPPIVSRLYQYVSEGMAGYNQARKIAFIPFPFPHAQITTLFVFVIVAFMPLLMLTFVNNLIMGLLLNLFTVLCFVGLHEVARELENPFKNVPNDLPLNNYQAQFNESLMIMFYGYHPDGHNWVPPQQEEQEEEEDDDNDNDQERAEDNGRRRSWSLGNEAGIAGIMDLEHGAAPIETSRPRLGRHVRGTTPFNIPEIVLEEDMAQSVLSWESDALPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS49</accession>
    <name>A0AAD2CS49_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001235">
        <property type="protein sequence ID" value="CAJ1944695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS49"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="205" mass="23149" checksum="F08EE21A6E84F145" modified="2024-05-29" version="1" fragment="single">MSSNEGRDEESTVYNGKPQDGQEPLHILVADLQEKMMTMETRLKRYEDQGLRKRSSTSRPSLKEAPVFTSMMSMGMDLDPMDEEEDDEDEVRAFPHSTVSFLLLAKWPLCGHSPPEDALECSQQGHVLRAKHRSRDYMCLPFWLSSGIVALQAGIYTLALYDAIDITNPKNPLKIPVNVDPFTRTAELIAVVITVYTQNNIFQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSI1</accession>
    <name>A0AAD2CSI1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF238">
        <property type="entry name" value="PROTEIN TIC 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF6824" evidence="3">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1943279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="507" mass="56260" checksum="6A017695F17216A3" modified="2024-05-29" version="1">MTSNPEPMASNPEPEPNPDYDIRPGQESASRQHPGNKNFLELVKASYEDYYRAGRAGKNAEGSEKGRIEFSIVKAVHDKGGRFLTKDDNGNLVPMTVREAMIKTRAALIGLHFRRRRVAAAKAAAKTASHAATDTRTQATGSTSHISLMAVETSQEEELEAYCRNQNMSSEEYLEYLDSTKLEEDVATVKSNSDRSAIASVLSNMSLTFDELKDMVDKIECVTDMELPGNNFYTGSIMNSLPYGRGLMTYKNGRIASGDWVMGKLHGQAFVLHEDGGYYYGLYSEDKEVGCGVRYHTDGSTFVASVANAASSNLTRIDRLPDMNKLAFCTNMELQEGKRYTGSTKFDESTMSYVPHGRGMQMIDKRGQLISGDWYNGKVDGQAFVCYGNGVNGGFFFGTYAGSRRVGYGVRYYADGSKHVGPYSNDKPNGRGKRTYKDGSSEDGDFTDGKLDGYVVKTSRDKIQTVWYYKNGIKRKEWTEKVSRERKDGDVAEASPTKRHKTGTSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSP2</accession>
    <name>A0AAD2CSP2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="327"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="469" mass="52832" checksum="96FA2B161C85555B" modified="2024-05-29" version="1">MKHHDFTVTTYNMLARSLGTNTIPWVMDVSPSIQRRIEQASSYDTFSKWVDNVLMPEYLQHFHKNFASGNYAAMRKFWGVPNCQSANDIPKELKGLKWIDEDRVSYTKSENSKETQHIATTMRGTCRKALPNDLFDSFFNEVISKEEGVYSWDTRGPRIFQTLLLSEPPGIIAIQEYDCHDVQAEYRKPGCVESFSEAMSAVGYSGVFLKDPLLGRGPPSGLGVFWMDSEFETLAGKTGIESLDCGEFAFDDSVSNIDLEEHWHPIKPDNSDFVMMKAADRRNGALCRLRHKRSGRKVALCTAHLMTKSRDGLKTNKFPGEVRACELAALKRLVESTTQDDEIVVLAGDFNTDAKEALGVFAGKFKSSDSEEGCEFQTGFDVKSKTFRWGPHVLQDAFAETHQWGDGVGAETHCTSRNANRIEWIDYIFHDGVQLETLELSKCVTPPALIPDEQNPSDHLPLNAKFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTA8</accession>
    <name>A0AAD2CTA8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000480">
        <property type="protein sequence ID" value="CAJ1935487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="118" mass="13251" checksum="941DE1AD0FEB171E" modified="2024-05-29" version="1" fragment="single">MNLSVAASLLFGADEVLIRGFETIAGLPAITDDDYTEQNIRIFKAFFGPTPSTICFVWQDILQSKNEELGLHPSDKSEKGFKRLLIALHFLWAYPKNAIILANTTGTSERMVQGEFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTD6</accession>
    <name>A0AAD2CTD6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001202">
        <property type="protein sequence ID" value="CAJ1944102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTD6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="557" mass="64030" checksum="BF6ED15031181D20" modified="2024-05-29" version="1">MDAKQEQIGKELKVANAQQQIGNKLKQQPTGNMDAKQEQIGKELKVANAQQQIGNKLKTGGQSIAENCNVDTAVERDTAVVWEQANGTLMDDDARQQQSCKKPPIASDKDGVIIPKKGIDGAMEEKQSVDDDDRSNDTSISNLNSDTKDNSSLMLLDDKVSKIWMDCCQDKESIPLPTQQDNMKQSPDLNQSQSTVSISWNQSTLPTLAEVLKRPVQQPEQNFGLEAMCFLRNIADRWFQLPPSAVLDNHISSWKLQKNARACFGYLFTLVQQKDLENRIKTMHEDMVDLRKKWQTTAQEYHREAMFFDIKVEKTFVQKSWDQLECIYLSYCIMKHILQIATCSSFDRQTAEDCLYFSFNMVVNDASRKHQILGFYASLCVLFPSEAHILEHKATIIKWWGKRTEGHAARSFYKWIRSEKFSTITNAKTTTRMKDALVKLGKYVFPEVGAKQNNLLMDEFHLLQQRSDTKRRKGLGTNNKAVSNVDIEWWSFLCAKAFTMYLYCEQNSNYKFHLAQTVNVAVGIEPPPRHQLCHHHHHHHHHHHHPCHLLQHLQAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU75</accession>
    <name>A0AAD2CU75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HslU--HslV peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01913">
        <property type="entry name" value="protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003964">
        <property type="entry name" value="PRK05456.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF7">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1936579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24605" checksum="9465D3C9DA7D22B4" modified="2024-05-29" version="1">MMNSILRKQMSSKVVAQMQAIRTTSAASSFHSSVPSAANEYHGTTILCVRKNGKVCMMGDGMVSMGNMIVKPNATKIRRILPKGIDDPQKGTLVGFAGATADAFTLLERLEGKLDEYPGQLSRSCVELAKGWRTDKYLRRLEASLIVADENVSLELTGNGDVLEMNDGVVSVGSGSPFALAAARALMSVEEMSAEEVASKAMNVAADMCVYTNKEFLILNIDASEAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUD7</accession>
    <name>A0AAD2CUD7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="356" mass="40914" checksum="2EB6F6B6FCF938C1" modified="2024-05-29" version="1">MDGDNNAESLRTPLLGDAQENNDEEAVVVDETADQEQPEAEDDDSETDTVPTRNSEASSLWSRILHTNVLPDANLFLEGDYLPDASYPLKLIKFIGLTVGMIALIHTFVRTNSHFSSDRDRKLQLWQIAVFEGNYIISDSIIFFMVGRLWKQRGVDHLAWILVVLLCNSYFECQHFFSWLRHSATLYEMHCIWPWQLWAFAGTLIPLIGGVVWLHVQKAWKDGIFGIKILEMSLIAFFYLGPTITSPYFHFHHWFAGWILGMHCNFDVWWSRAAMAWCWGMYINGIAVYGRDPILTCEYAYFVSTDNRCPFVDQETAASAFDYSSSLFFGSFNDVLLNKMDPPADWRNCSAHGYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUH7</accession>
    <name>A0AAD2CUH7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001624">
        <property type="protein sequence ID" value="CAJ1946160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUH7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="108" mass="12192" checksum="62C8502DFEF2F536" modified="2024-05-29" version="1">MHRLRNRAEKEERRIKQLVGIANSVGQVRPNRSYVSGLSAPPSPGGRALAGFHQQQFQGFQDNCSSQTPTIETAELSASLKKPRGLQTKERSETTQKRDNKLQGRWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUX9</accession>
    <name>A0AAD2CUX9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001213">
        <property type="protein sequence ID" value="CAJ1944164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUX9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="593" mass="66027" checksum="D7E6106D620FDC51" modified="2024-05-29" version="1">MTNNEDLLGLNASACFHYMGQSDVSRSITAVAVDSSIQDIAPETFSSCTHLTQVDIYGHNLKTIGGSSFKKCQSMKTILFPDSVERIEERAFSACVSLTQIGSYPPKNTTTIIHTSSSADDQDRTKKIPHTNPALPSNLKFLGPAAFHYCKSLTSISIPSTVETIREYTFFYCEALVDLTLKEGLKVIEERAFQGCISLQNVAIPTSVEKIGKYAFFYCLRLTEATLPKKLTDIKARSFHDCKALKFMKMQHTAIQSIEANGFYFCEALLYVDFPPTLQRIHRSAFESCKSLKSVALPPSLTAIEQGSFRGCRSLIAVELCNGLEWILSKAFADCESLRMIVLPAHSSDRAGEYAKNAFSGCSMLEGRCFGGDLLTSLTHRFDKLPIHKLCYNAGSTALTVEDLATCVTQHVVNQPEQDGACVDSFGMTPLHILGVSAKPREDFFLELTNLLPIDTLTQNDKYGNRPVDYLCQNEAPNTANLIQMVLQRTMLDRMNHWGLVQWREDLSQAIRSITSASNARAKVAFLSWVESKLAQYERLEVLSLLELTLWKIAVTMAHSQEAISFSAEILDRYSYRIRCGAETIIPSVCEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXJ4</accession>
    <name>A0AAD2CXJ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001669">
        <property type="protein sequence ID" value="CAJ1946442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25486" checksum="4A4BD446749FD2E8" modified="2024-05-29" version="1">MTVTLAPITVPLLGLISIAMATPLRQTLFSMFIPRCMNKVDEEFSEERTKLLSTITGGSVLDVGSGGGAYFRYFSKADRVVAVEPQEIVYPKLNEAAKQNGLVDSSKDFSIVGDLKDVEGTFDHVVFGNVLCEVPNVDEALQQVDKLLAPGGRVYFSEHIGRPTGTWIRLFQDWYNPLHCHMTLGCNCNRDSLDKIRSMKNWDVVSWKYEHFQVCMGPFVMGLAVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBG5</accession>
    <name>A0AAD2FBG5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37231">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37231:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041990287" evidence="2">
        <location>
            <begin position="27"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1923106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="215" mass="22954" checksum="78CA3483D224F94C" modified="2024-05-29" version="1">MMVKKRHGFFGLLFLFCSYATIPCRAYQPSSRKSWPSSVSVADTKKSFLDIRIKTSSSRCASVLQQRQSSLSFSPFARSLSNDDDFEISDGNKISPLGVVGIASQPIVWVSLGFVATTGAGLPAGPFGLLGAVEGLSYLIVVGLVASNVIFQERTSDSSLETAQKLSSFTLLAALLTLLSLVKDQGCIPNAKPILDYSNYLPVCSPEDTPGIFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBP9</accession>
    <name>A0AAD2FBP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Fucoxanthin-chlorophyll a/c light-harvesting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CYCCA115_LOCUS1338</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000025">
        <property type="protein sequence ID" value="CAJ1927692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3460.10:FF:000011">
        <property type="entry name" value="Fucoxanthin chlorophyll a/c protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0157">Chromophore</keyword>
    <keyword evidence="14" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="15" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041942286" description="Fucoxanthin-chlorophyll a/c light-harvesting protein" evidence="18">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAJ1927692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22094" checksum="A442025A39E4D1EE" modified="2024-05-29" version="1">MKTTILATLLSAAAAFAPTKQAVQTTSLSAFQNELGAQEPLGFYDPWGFLVDADQERFDRLRYVELKHGRISMLAFLGQIVTRAGIHLPGSIDTDGDSFDSFPDGLAALFGEDAIPTAGLAQMVAFVGFLELVVMKDVTGEAEFPGDFRNGALDFGWDTFGPQTKLRKRAIELNNGRAAMMGILGLMMHEQIEGNPVIGVFIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE68</accession>
    <name>A0AAD2FE68_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000202">
        <property type="protein sequence ID" value="CAJ1932049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE68"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041951142" evidence="2">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="150" mass="16598" checksum="996E46CE3925B010" modified="2024-05-29" version="1">MKLSFVVPFLAALIGIANAESVGTIRGIKARDPDGERIRSHKHHSKPPGEGRSYHNRHGSGRVGGKDKPRDQEDKVIHTSTHAEDSAGDKPRSYVESSFTFDGQGFRLRVVIGITKRLQQSIKVNTFLSVLNIGKRSSAPCLPQEKRSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FES5</accession>
    <name>A0AAD2FES5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1888391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FES5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06859">
        <property type="entry name" value="PX_SNX1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="30"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="3">
        <location>
            <begin position="196"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1888391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56058" checksum="BDD95DDB048D9834" modified="2024-05-29" version="1">MIGAPVPPPSKPPPPAPQNVQQQRVKPEDAATHISVSDPVQHSEGVNKYTSYRVDVRPQGPDLGQTQGFSAVLRRYSDFLWLYEKLQDERAGAIVPPLPEKKPTGRFNPQFIEDRRRSLERFLRRVAVHPELQGCNCVDTFLRADDVSFHAAKHSKNNVVLQQSTMMGSMVPGAPPQLMPKPKKEGFKRWFAETKTSISGDLVRSPDDELFEEIQRYVHGLDSQMKNVQTQASGLVGKGKEIANGLFEFGLAFNLLGQSEADALGDALGKVGETADRLSVLSAEHADKEAAEFEDPLVDIIKTIHSVKMALQKRHEKRLTYSTCLQSVESKQHSLAKLRAQIGMEAKAYGTEMSLRRAQDNAELAREDFAATSQRVLREVDRFKRETAEDMRRTVLEYIQMQVEYNKRMEEIWAALIPQLERVQLDGDANVVGDNHHVAPSPSNASMMQSSQPAIHSQPMVPNPQQAMPPQMGSQFYSNTTAPPPPVPHDPDNPFITQYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF10</accession>
    <name>A0AAD2FF10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS3559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000324">
        <property type="protein sequence ID" value="CAJ1934019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF10"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06231">
        <property type="entry name" value="M14_REP34-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055438">
        <property type="entry name" value="AstE_AspA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24827">
        <property type="entry name" value="AstE_AspA_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="8">
        <location>
            <begin position="44"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1934019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="345" mass="38437" checksum="334352C68B0B2301" modified="2024-05-29" version="1">MGILHENDAAPPKDIQRYYPIGTPGKPWTKEEDDEWKKLTKLQRSYKEEVLDKLTAMQVDSSSNNEEWFEIKQYGSLSHNPSKYPLMAVQSKAFDATKPFVLVTGGVHGYETSGVQGAIQFLTQEAAKYAKDFNLVILPCVSPWAYEHIQRWDAELLDPNRSFQPDDESKQTEESKALISHLKQIEESAKKSNDIGETKPKYFWKCHVDLHETTNTDATEFMPAKHAKAGLPYEGEVIPDGFYLVANNANPQLEFHQAVIDKVKKVTHIAPPDENGDIIGEPVVQEGVIQVPARELGLCGGVTLGEYATTTEVYPDSPKATDEICNRAQVASVVGALEYILTKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFM6</accession>
    <name>A0AAD2FFM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="140"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="32739" checksum="185DD28C442FD1C9" modified="2024-05-29" version="1">MATKKLDDDDDLNNRRNQTIIKATPIVATNDSWVTLYEDVLDPTDDDSEQILHELYQNLPWNVETDQFGPQSRPTCYFADPECTFSYVGLKLDPPSTGSTPGNNKWHPTVQKLRECVTRLLAVAGPDDPSSPSNESSRPLLTACLVNLYPQNKGFIPWHSDEIRAHGKDKVVASLSLGGPRRFQLRRRRRVDSCNHHTEEGETKPRMVADLWLPSGSVLLMKGEVQEHFEHCLPLEPEIIGDDAAAGDDAEMSFKKRQEDVTINPLRISLTFRSIVPGYESSNNRTIATDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGG9</accession>
    <name>A0AAD2FGG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43592">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43592:SF15">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042011183" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="3">
        <location>
            <begin position="185"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1936545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="31434" checksum="8FDD249D6BA03B5D" modified="2024-05-29" version="1">MTQLLITILCAALLICSNVAFGFQSAGPSHLAVSSHLLRSHPPSSSTHQILATKQIFSRRQTIRFLSSDQVEDNDPSIKIVKKKDDTLFDLKTTLFLVGGQSLLIGIAAGFAKMFNIPNFGLGPDINLNLSALQQGFLMALPMGGLAALLDQVEDKFPALQDVTKATHKSVLALLGGNFKPLLGLIIAIALGFAAGFGEEMLFRGVLQYGLAAKVGTAASLVVASLIFGALHAVTPLYALLAGVASVYFGYLYLSFGNLAVPIYAHALYDVGALYYAHWTVSQLSDEEQSELASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGX4</accession>
    <name>A0AAD2FGX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1349 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="24651" checksum="0CC07439A33B0988" modified="2024-05-29" version="1">MKVTRQDMRWTNEPEKWKQKGDDIKCTCPMEVDYWRHTMHNFVKDDAPFYWMYVDYDFEVRLSVKAKLEYLYDQAGLMIRLNEENWVKLGICHYRDYPHVSCCFTRGKSDWSMQILPKKKIKWIHLWAKRKGNLIECYYSLDNENWLRVRQGYFSDAPRLRVGMMCAAPETAGFDVTFSNFLIKGDVDDSDEEGEEEEGSSEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH63</accession>
    <name>A0AAD2FH63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1938042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011643">
        <property type="entry name" value="HCR1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07692">
        <property type="entry name" value="Fea1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046921835" description="Calmodulin" evidence="3">
        <location>
            <begin position="27"/>
            <end position="2233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2127"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2185"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2185"/>
            <end position="2203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1938042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2233" mass="243312" checksum="07236F1347B59538" modified="2024-05-29" version="1">MMSPTTMRRSIFLLSLLSCQCFIVDCITLLGGRFETTTDVQTFLNLALDAAEMKESDDFDTKKAIYTAGVERENEASVDVSLAALSLRAMGDMLENPYFHMFRHAFLVLGNAEEGETEGRFDGATIEQYGDTLVNDLFELDVEGIETEAAVVLNVWMAVINELFQVKGQCKANNMNMGLAALDKAAAMWIGEGQDSGVNDSGHLLYNLAENAGERFDQDNGEAVVNSKIVDLFVEIQKDLRAGKCGELTGYLNVRGQIRRMVSLMTIPLVQNLIHYTLNVSIEHGADWVELYALATIPRIAVCSPEDYDQTLHLDVLREMTPDYANQALAALERSYSCFGITCADVGSYRGGERPQCDDVSGVNLVGYTSSREDIREKSYLDRDIKTIDVLMKFKAYGLALDWYEYGWNSVYNLQGLAKNEVIPTSSKAGKNMFQTFADYYGGADFADRYIMKLIEQQAPYNAASDEQIRWLLTNYLSNVVMYFSAGAAFQYAVDQCETDKETALDYWDTGAMFYIGSMEGELPEGNTAGGLLLFSTAKDLCEEFGTCIDDSEVGGSDIPKAMSNELIVAGLNQGLERIEGQQCNFLGDILTQDIFAAMPIPIIQGTVKYASFVSRLPAGSDAPSLAIADAFSKGILPLVDVADATSAGKIQAAMEFSLTDKPGDYSTVVDALRSAIPKMNIDCNQVGDFIDESGDASLCLGGGGGNSNFPGEGSTPVTAPTRAPLPVEPGSAGAIAWGRYSFSVPAVALGDAKFALDVRAMYEAADIVAATSVYTNGLNALTKNLNGTNGLVSLKSLSVDSSAVMSEDPLFNVFKWALYDDKDVGQNSQQNFQYADDVIQEALTNGNDMRLAAEGSVIFNVWMLMAHRLYEAVRICKQQQSPFEELDSVVALWIGEGQAEAEFDNGWMLYSIGQSAAEYYGFSEGEAPINTQLMNMLNKAQDLAQACPSGADAATDFRAHALHILRRLAVPLVNSLLFHMVANSKNMVELYAVSVVPQVYNCDGDAAVNLESVLYQGYTYAKVDDDVIGDLATFLRCKRITCQDIRVSETADSDKLKELVGKLCEKLDYWDNQGMELPMAGYIPSKDVSEISRLDLDILEIEMLAELGAFKAAQDIYENGHHSFAKADGSLRDLQSIARMSSLDEMAKFHLYSEYYGSLDFADKLVLDALNQSGDYVGASWQERSEIVSRALQTMVSYMAVQARMQEAVDDCKDGKAGLAELKWNEAAALWIGSAEGLIAAAKFDVGRFMYSLANDVCGDFQACAENAESLVNQNLLSSFASGRDSLSGSECTHIERTMTEEIIPRMAIPLIQALIVNAIEYENPVADNKYSHATVHVLAKALIPLVKEVSTGSALTLANNYGSFQQITLGQSAQPVVDALASVIRPLGLSCTEIGTLNGDPNWAKCGPNGGIDADGDGDAGGDGEKDNDAIPVPETPTSLGDDLYVTSTFVKDKAKIGLDIRDMEKQLTAGNTNTAKSIYENGENSEVFDTDGKYVALRSLRSFSLESSKDMVDEPIFNMYLYTLSDNDGNFKQIDAREYANSYVEHAFQNIVASDKTLPAEAAVALNVWMEIVHQLYRTLSLCEQKELRDEEGIQSMDIAAAYWIGEGLDSEEDTKGHLLYALAEDMGSRFNILEGGQSRTNRNVLRLFNEAKTTLALPNACSENPTTYLNIRHTVNKIRSVISIPLVQSLIHYLRANDVERVKLYAHAVVPLVAGCNQATFEYLRDRLLTGNYNAIEIEKIVDKIRSVYSCLGLKCDDIGVHASEVNDEAPSCIDEGVRGNLAGYTPANDVSDHSRIDLDLREIDILMQMNAYKAAEETYMYGRNVENPNGGILSLSNIATTSGRSIVPQYDAFTRFYDDKSYVDKIIRAALRGDGIWSGEQRRVLVLKAAQTIVMYFGALQAAYEAVSDCSTVVQSRSSTTKSDAWDRAAAYLVGSLEGSDANGTPEGYLFHSLAQEHCEAFNTCVSSTGSVDVNDQLIDLLYAGRGAVLSDSCSGLQKIAGELASLILIPSIQGALITAIRLTEENDAATAPLRRAEGYVYSRALLPLVDDVNRDAAGVIEKNLGDRKPAKGTQIASEVFSSFSSVYPGLGVDCELLGRTDAFNPCSGVAKDTNSGSTGSILLWSGVGAGCLLLLGALIFFCLRKQEKETLPENNPKFIVSTGEFNNHSMNLLEKAFSNNKTAPSSPEETNRLTGTTDPSIDIISDDDDFDEAQALRSRIDSTPDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI29</accession>
    <name>A0AAD2FI29_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000947">
        <property type="protein sequence ID" value="CAJ1940741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="284" mass="31981" checksum="EC7F0FB5B3B0BED6" modified="2024-05-29" version="1" fragment="single">PVSHVTHVMDLQLIIIDVTASKLGELSRLFSESRGKPDEYFGGIPVLLVGAFNQKEPVGGILATTTLMKKVQNEQATLQQHHTASNTTKQRQYRSSTSLLNANVHNTASDSSLGSSILSASRWFELTVAERSKDMKHNENIDKLYDGMQIHLDKFHIYEFYNDKNLMADTAEERLMWLKAPVIVKTNRKRCTINYSRGLQFAKATNAVLVRWNLDYSKWEGKPPNLSDIEDTIDRDAAFWEIFVSGGPCYLIDTISKERKLCNGTRAFSCSQPGTNGFLQDADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI64</accession>
    <name>A0AAD2FI64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000284">
        <property type="protein sequence ID" value="CAJ1933604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52597" checksum="41C6B97E9A064FA8" modified="2024-05-29" version="1" fragment="single">FASLAIFSANANHLPTTDFGPGCLNFQDDGSWNQVPDFVTNDPFLVAPESPFRFSSDTRFPDQAVRVGATGELSASDYDWTLGIFDTKAQNGGAIYEAWYKSNDHGTFATTWHATSANGNKHNTFQIVISEAIGGDMGEGNNVCFCYGDMQWGPGNVHVASSNSSDHTHVDFSGGTYQNAAADNSLDHKTCCFHADKLKQLGSSADFASLCHSRGTEAGSNGDPHFKTWHNQHFEYHGQCDLVLTKDPDFADGLGIDVHIRTKLVRHWSYIKNAVIRIGNDILEIEGSSVEFDSKPHYWINYESQGELSQFAGFPVKMFSQQGTAVTKNRIEIDLSSVYPGQKIVLSTYKEFVKVSFENANEESFGTSVGMLGDFNTGQTLARDGVTVLDDFTDLGHEWQVLPSDKHLFREASAPQFPETCIDPEDPRGDRRRRLDGSSIGEEEAETACAGIKDELDRKDCEYDILATQDMDMAGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIR8</accession>
    <name>A0AAD2FIR8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c-552/DMSO reductase-like haem-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS8485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019020">
        <property type="entry name" value="Cyt-c552/DMSO_Rdtase_haem-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36044">
        <property type="entry name" value="HEME BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36044:SF1">
        <property type="entry name" value="HEME BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09459">
        <property type="entry name" value="EB_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042013866" description="Cytochrome c-552/DMSO reductase-like haem-binding domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c-552/DMSO reductase-like haem-binding" evidence="7">
        <location>
            <begin position="53"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1943527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="324" mass="34607" checksum="A57C879EF0095F2B" modified="2024-05-29" version="1">MKLSFKSYQAALLLASASSVLGASHTASEPCSTTWKCHPVKTTPTLDADHSDWADVEAYTSSLVLISGTEYGDGDLTAKCQYDSENIYFAFEIPGKYRFSATDNHLCAAIATMFKVGSEATYTNMGGCPDAISGCADGVPDTCTDYRVDIGAHWELATTEQRTLYPVNNTATAGTGNDPIANKDDEYAVSSYCRFDDDDANAGNEWAGAWAHTSTNATEGEDGTYHFEMSRLLKTPSSMTDAQLTAGQTYEFGVAYWDPHQSNETGWTAINHYITGCASKWIELELVSDEGDNSAPAAGDSSSSALGLSSMVAAMAVGSVVSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ62</accession>
    <name>A0AAD2FJ62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS4471</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042246221" description="FAS1 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="162"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="305"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1935133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="707" mass="71735" checksum="E7B40ED00EADDDB6" modified="2024-05-29" version="1">MKYTAAILAAVFSVANAQQFQPISDAGEYSALLDAVVATGSGFTLVSAAPVTIFGPKDSAFTAIQDFFDNLSVEELSSILLDHVVVGTAVNAAAIVEAGCIEAQSAGGLMLGILFNPDDSTVTVNGIPVTTVDIAGDYGILHGIESVLIPGEQGDFVPCPVFAADFTPIADKGIYSTLLGAVVSTENDAVISQNVPVTIFGPNDDAFAAIQDTVDSLSTEALSGVLLNHVVVGAAVESSAVVEAGCMEAVAAGGMNLAIRYNTTTQVADVNGIVINDFDVTGEYGVFHGIASVITSSYGYVACPVLSVVEQVAANGNYSTLLGFLDNPLLQGQLENVGPITIFGPNDAAFAAVSSDLDGIHQVTLLQTLAGHIVAGVHTVADVKAQGCVLLDTILGTKVRAMYVEDDHGDNFRRRLAGHEMPTDLCCRRRLVGHEMPADPCCERRLSGHEMVDDSSMGHIMINDAMVILADIEDGTSIFHGLDKVLLLGGDTFECPTDAPVASPTAAPAPTRDDETADEGSSAGPTTAPTRDDDTADGGSSAAPTTAPTRDDDTADGGSSAGPTTTPAGDDDTADEGSSAGPTTAPAGDDETADEGSSAGPTTTPTRDDETADEGSSAGPTTAPTIDDGAADEGSSAGPTTAPAGDDGAADEGSNAAGRTTARANDKGAVDKGSSAGPTTAVLVAVVAICFFVFLAAFSVYKIIRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJF2</accession>
    <name>A0AAD2FJF2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001215">
        <property type="protein sequence ID" value="CAJ1944173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="18078" checksum="DD0DEB702FFE8A92" modified="2024-05-29" version="1">MELISLPALRAYWSSKDRLSEQSIHEVDWLSLACAMKAFPANLQLWTPKHISGMTGVGKSLAIWNPWAKSSCPRCSSCQVEDYLHVPRCSAPTAAAEWSKRHLAFRIWMQTRQTAPEIEAVLFEYLKTVLQPSLGVPTVRAWSRQPHLFQSAISSQAKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJW1</accession>
    <name>A0AAD2FJW1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJW1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="507" mass="55253" checksum="7DBA13AB95AAC8AF" modified="2024-05-29" version="1">MEFQEVMSPMTTPTTCYSGARNGECNTIRLATESNLLGVHIDYKHGIKRVSSEAIRSNFICVGHSQWDNDHNTSVFLNPSRLPVESDEPTLSRPLDRDDADASVVSNSVPAGGASVVSTKSIGTDPQSKSNASSLNTESKSNENQSSSEPEKMDGRLVLTTPEAEYTAVLTGFRPLSPCLACWGDISMGVWLGSADDSQLRLYMPNRANGTLDLVMSLPSEVLAFKTSVLAIDFASTQSLEVLAVACQDGTIKLITWKGDAFEEMGFYQVIVDGPILTVRVQESLGTLNVFVGSLCGYVCLLSRTESHGPNQWDGPKMVVEGLHNQAIESADSVVVVNSFDNIIAVGTHGGRCILCTRIKNRYVKVWECQLPYSVHGILLQRDEDGDRLLLLATTRRSLHLFLKTNGKDFSKGNGLESEATYCAANVQNRLVALLKPEAPLHPEIVGEVEDSNNEVDEPENIQVEEPDQKDEESKNEAEDHSSHETSPEELVAMAKPEEEETAATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLF8</accession>
    <name>A0AAD2FLF8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000946">
        <property type="protein sequence ID" value="CAJ1940715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLF8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="486" mass="55373" checksum="DB013F0D1C533B06" modified="2024-05-29" version="1">MGKEYIDKVTSNDILWTKNGREKKAHAGNKLFWKIVEGAFNDHRRNSSNLMMAFHIVDKLEEFDPPMRLLQFDKDVGKYYKCSTSNAWQRIQQAFNSLESSTAPDKTKKRAAKAMTKRIITGAKVSRQYEDDQDSNPKQKSATPQPTKESTDNLPPAIVSPNQLQDEEETTWHLPENEAIIPPLPQNRDETNVQKIPITATVGNHASSEMELDWPEEQDDQAVVKVYVDEHDFTESDILYRGRRRGKKADIDLPSDAFRICLQETFRKYQDSCQGDPSAKRRFHLSVLYGLRQLNPDIRFLKYNEAVGKFHEWNHREAIEMILLEMEGQSKPRPVATTPQEDDTSNNTISSPSLPIALDQPQVKLPVSRTTPATIEIADGNGEGEQHAVLHEEDMDAPANNNLETRKCHNPGVDGASQADYLEEEEEEEYDEEEENKHMEEMNRAMELGLCDSSSCDTSEDEAEPDTEIVNVVEWTNPSHDIICID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLK1</accession>
    <name>A0AAD2FLK1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001003">
        <property type="protein sequence ID" value="CAJ1941420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="196" mass="22383" checksum="962FFA74805A4AA5" modified="2024-05-29" version="1">MVKSIQDGKSIDFNAIAPRLNAPTQTEAVARETEMAQNKILYSAKLDENMQRSANKRTVKSNIMLKFVTKAMDIKLQGEADFTTTLEDPIELLKRIERFMKKSADAEYDFLDFWEANQKFFAMKQGTTKNLMHFKERFLRQAEVLQDLYGVAWFQDFAVKTKAYAAIASTDTAAQNKFKDDVFEAVLATGFLCNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNH9</accession>
    <name>A0AAD2FNH9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS11075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 99 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572">
        <property type="entry name" value="ENDO-ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572:SF4">
        <property type="entry name" value="RE57134P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16317">
        <property type="entry name" value="Glyco_hydro_99"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1947295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="574" mass="64844" checksum="FB7EAF2265EBB205" modified="2024-05-29" version="1">MSSYLIYSKDEAYSRRTAAVIGAADASPSLRRVPDGEESLDYKFRETEGIKGPEREAAAENSSASASIDDEIPSHHELEASASFLDEYHDHGDKKKNMRKNPRYNPRRKNSGASTSSSNDSIQSYPAANNSRIMEIYCLLLSVALLFTLGLMAGRHIWEYPVSSSSPSSSVISGVRDSSDKNLQDTPQIPKITVGTYYYPWHGGDFHRGAGYVRKSLGQSPALGEYDDRDPNTISQHLAWSKEGNIGLWVASWWGAYEREDNTTRTVILNHEELKKGGPFENHKVALFYETFGRIREEDYYSLHRIKPDMEFICEHYLSHPNYYTLDDGRPVLFVYLTRHLETLVRFESVIHIMRKTVKDACGKDIYIIGDQIFGRFDPPGYEVSAEQRLVEKEDKLYSSTPTAFDLLDGVTNYDVYGSMGATLRTFGGYVAEDSVADYYLTVQRKWRKYAKEQKGCSFIPAVSPGYNDLGVRPKEEHTPLARSLKRATRGGKDSGSFFRVSIEHARTLVDPSASYLLMVNSFNEWHEDTQIEPVIGEPASTPYNMTFGIEYDGYGTLYLDILRNGTKDVNIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPB0</accession>
    <name>A0AAD2FPB0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="196" mass="21788" checksum="A016271921D7BD47" modified="2024-05-29" version="1">MPNSSTRRGVTINPNVKVHEIFPLYEYTASEISTIWYNEDEMAEISRSCAKILRRLESVGSAKESKYCIRGLETHTRLGSVVKRSNRAAARAAVLAEQARQWRNEKGENGAQAICDAYRRTTSSCQMWAQAVGRRDQQEVEAYLCNDNDDVEEEEEEESVLGRKPSPSSTIACSPSQESRIVLRAANTASPSAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPM6</accession>
    <name>A0AAD2FPM6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001752">
        <property type="protein sequence ID" value="CAJ1948719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="380" mass="43473" checksum="B481C2D3BD9003A5" modified="2024-05-29" version="1">MRFSKVFKQRYDKWLRKEFHLAEKIIENLNDWLKAWIDVSDDSDRKVFTYKTEDTTREQFSKVPYVLDHEGAATYRGVKSSAEHGLTEWRSSRAESSLEKFHELLAHFANIGCKSEFANALIARGTAEHNVGARWRYDCMVQRQQGSRLPHPEYVDRTPIFMDHSLLDHLNQQSTSLGFGALFKECRVPEVGNEKEVFFSDYCTDQMERNKQEGTVASTKVCLCDDCKDKYESPQTTSVARRRSGIARAVDRSAAAARPLPQQHMQQQAADHSTLLQWLPNNPTFNPVHASTTSGFLTPNQFALTPNQFALTPNPCAFFTNQSAPHSRTVCKSRCFPNYPFNCTRFAGYLERSKSGSVVGRPPHDLWCPKVQGYYKYGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ45</accession>
    <name>A0AAD2FQ45_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ45"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002395">
        <property type="entry name" value="Kininogen"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00334">
        <property type="entry name" value="KININOGEN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="220" mass="24066" checksum="B6D54F9372AE4495" modified="2024-05-29" version="1">MVNAIPEKVKACLGELTPAQQVTLRGYIGTLRAEVKELEESLRTVNDPDPHAHYHGHEKCTADHGHDSHDHAEKDHGGHDHGHGHGGHKEETKESHGHDHSHGHAHKEEPSCGHDHKEGESCSGHDHGHGHAEEKKEKSGHDHSHGHAHKEEKMEKSGGHDHGHSHHAEGKSHDHKEEKTIPAWKKRAMEAAAADPTAAPFGGSWNTETSVNASANKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQQ4</accession>
    <name>A0AAD2FQQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-galactosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="3">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="2">
        <location>
            <begin position="238"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1949829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="63235" checksum="04D880BF62D73FA4" modified="2024-05-29" version="1">MPVPSTVDTSPPGYMKSRGVFFFQRRFHFDLKSVGARLQFQGCSFYCRVWVNGQEVGDHRAGGYVAFTLDIPPQASVDNEIFVLVDDRFNKTTAPTHTGGDFFHYGGIMRSVELHALPPPREGTSGSSLSLWPWRLYVTPDSLKSVNVTLHVTDRTYEGPIDTQLRVSFDEEPFVEYPPNSFSAVDGVASLGNMKVPNPRVWSTLDPQLHTVTIEMDGAAMVERFGLRIFDIDEDSLRIQLNGEVIKFVGWNHHTQWPDTGGSPTEQQMDDDILLLRHGGTNFVRGAHYPQDPRWLDRLDENGMVMWCETLGPDVSVANTIDPYFLKYQTQQMNEMLDNAMNHASIAIWAYFNEGPSGNNASCPAYQMNANIIRSRDTSRFVSYASDKHPPSDVCFKDVVDVMAVNDYPGWYNPAAPKERWSSTAKYYNEAGKPMIISETGAGGIYEWSSNSTASKWTCKYQTQVLVEDVDIAISDARVSGIALWHFFDFKTRDGDENNTHCQYLLNVYPPVCEYINVTSNRPGGANHKGVLDFWRRKKPSFDEVARRYKAASKSVPISVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQX1</accession>
    <name>A0AAD2FQX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TraB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PHEROMONE SHUTDOWN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530:SF7">
        <property type="entry name" value="TRAB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042110445" description="TraB domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="42200" checksum="6F53F7E5DAD7771F" modified="2024-05-29" version="1">MKSKYLQLVNIVLVLHLSHGWNSRVPTRVERSPHIALSARDDNNHLEPINTSRRKWLGGALSFVGGSMLCPILCPVLPSNAAEAVKTGSVCDASVSVFQKGGRVVYLLGTAHVSSSSAELAGKLVVDTQPKGVFVELDPKRVKGSGILARRVSIDETTGQEVEVPSSKVIVPNIQMLTSTSQPSAAGEDAPSRPVSVAPISKPSPMMQAAGAAVGNSIKGMYKKLDSAGFNAGEEFVIAIREGQKIGADIVLGDRDVEVTLQRVAEALSKTDINTLLKPDSELEQSLKELVPNNVAANKDGDLSDAQYRQDFSDFVETVKQKDKVRQIMGQLKRVAPEIHTALLTERDAYMAAGLNGLDEIESIVAVVGIAHVDGIEQSLAMNGWKPASLRCPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTX0</accession>
    <name>A0AAD2FTX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS14052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1953452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="212" mass="21993" checksum="A6E04F6690A48A79" modified="2024-05-29" version="1">MVDQGLPIDAQCPSSAALLGYGGVAAAVCLSNWGSAMGTWKAGQSVIYTGIRHPSSVMKNVIPIVMAGVIGIYGLIVGVIIGQSITKPSNDRENAYSTYTGLAHLCAGLCCGISGLAAGLCIGIIGDYGVRAVGYRASAVTLFPTSQTEREGYSNIPDSDEAAENTIDNVSGSDDQNKLFIGMLIMLIFSEALALYGMIVALIVSQHSYSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUL9</accession>
    <name>A0AAD2FUL9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001833">
        <property type="protein sequence ID" value="CAJ1953563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUL9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="585" mass="66352" checksum="1BDBD1EEFD111532" modified="2024-05-29" version="1">MGKYTSLKVVSTAAKKAGGSKSKSGSTSKKSGKKRLENASSVELRQPKDRDPKISNDSGTKEVINTLRPLIDFGLSTQDLVAIGYDKNSTQIEFGNHVFTKWMDDHNAHWSQALPRFDSPFQDFYAKFLDRLPQVLGDSNNVVCGVHSLTIRSMKTSRKSYLIKPEQLACRWRTSIECARRTLEKTTQRAVRDCSVFPNVSYLMMPDDAKSLTQGKFREVANKGQVPIHPIEPHHSNEALTEDIIREGSRLYRRFMHARNIPIAFWDRVFMYAFEIRSHMALGLAIQEGECGATIVSGNTKDISHLVDFAIWDWCWCLSPNRSSKDGKQLCRWLGPSFTIGAALCFAVAIANGQVLQRSSVIPLSAEERNSEPMEEKKKEFMEDLKKNLKKKSDGVSISEEELDRIRHKYNMPISAIEDGGYPQYAQYEDHPQEDPHGVEAFGVVQGRKRDSSGKLIGHYRENPHLDTSIYQVEFEDGKVESFYANQIIERIMMNVDDEGNTMYRIREFIDHQRDRQAVRGDNGWYTTSSGLKRPQKKTKGWKVLAEMKGGETEWLDLSVAKEAFPIEVAEYAVANKVVSEPAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVY2</accession>
    <name>A0AAD2FVY2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVY2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="178" mass="19587" checksum="19F554DD010776AB" modified="2024-05-29" version="1">MSEGEKPTEEGTAATPPPPTNETTASTDAAVNGHFSPASHSSEKVWVQTVEEDSKEQEDHKKEEEEEEKKYKAYEQPLADKKQADSKDIETGNSQEEEKTKRASFGSASSSSSSDGSSELAALKREMTVRKSRMDIETLTLMAKLERKQKRQKQRMIGLGVFVVVIGGIIGIIIALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWL3</accession>
    <name>A0AAD2FWL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS15287</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWL3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010277">
        <property type="term" value="F:chlorophyllide a oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013626">
        <property type="entry name" value="PaO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08417">
        <property type="entry name" value="PaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1954695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="451" mass="51577" checksum="F816949C679B8B4D" modified="2024-05-29" version="1">MKFPRTWVPIASTYELDPDRPTPVEFLGQKFATYQDNDGNWVVLDDACPHRLAPFSEGRVDRETNRLQCSYHGWEFNSEGTCMKIPQMTEEMQAQVPAKRSCATTYPVQVVKNILFIWPWEEDCLSVLGNPNAQPEGILKGFPEDPSTYTRDLPYGWDTLVENLIDPSHVPFAHHGMQGKRTDAIPINMTVPEDKGEAGFSFEWEDRTMGMMRSGGGEFRAPFLVNYDAKFMTETPRPFRLSSLCIPTKPGWSRGIIITWKSEDNEKADREAMNPAEVELAALSATKQTKKKKSLIGMIFANLPIWLSHQLSNKFLDSDLAFLHFQEQERGKRADYFMPAPADRCISALRKWIDKYTSEDVVGPLPTSLPRSAMFDRWSQHTSHCKHCQQGLVTLQKIRRSSYITLALSVLGINKHWVPKITALLSLGVWRIVSKLENSFREGEFKHYENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWV2</accession>
    <name>A0AAD2FWV2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWV2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="321" mass="37505" checksum="47E9C9D6D7FB9B0F" modified="2024-05-29" version="1">MGSSNPADDTRRDKKKSNKSPHRNKSIDELRERRNRKKAKEAERKKQEEEEMSTMFDEPPPKSPEELRQELDEIKRKLKESKESKVQKLAEMEKNMKETKKELASTFGTEIDGKIKEKQRHDKHHNEIQAGAQKIMAKLREENHGLRATATKFPKQNKELKRTNNAYDRTTQQILMQNDALQQFCDKLQFDQDKLQMSSDIHRDEYIPFYRVEIREKQREVDLEKKIRNIYREAMVKVCKRIMNTRELDLIEIVSELIAEVEGEFNPSFDPSVLFVREDGTKAKDKDSDSDDDSDDDSDDSSSSSSDDSSALESKSDPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWW7</accession>
    <name>A0AAD2FWW7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15737</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001884">
        <property type="protein sequence ID" value="CAJ1955406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001884">
        <property type="protein sequence ID" value="CAJ1955408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWW7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="334" mass="37924" checksum="90B334E684728A5E" modified="2024-05-29" version="1">MNSTPAPPAGAANQPVSPATSTVGNTAGTPANATAPPGRTLASLEFAVTTLFQEPLDSPLMRALRRNGCLHFMHLLSYNENELLALKYDAPVIDQYGVDTGQTQLTQLERPHRGTVRALLGYAYLRQNVHCDPITPINCMHIDVQAFLNYQCSGDFIVFNNSSLPQPLVSKPDHRTPADSFQKSLKLDPDTYPTLNTDEEWDSFHRTFCSTARVHDTLNVLDHSYVPKSVDERDLFQKQQAFMYTIFLHKLQTNTGKSLVRKYQVNFDAFIWITITITVDDYAKTQRHKRVLVPILFRWFYISVFQPYWKPKGVKRWASAEPVLPPLVVFCFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY13</accession>
    <name>A0AAD2FY13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS15132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY13"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044624">
        <property type="entry name" value="Mbb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44917">
        <property type="entry name" value="PROTEIN HIGH CHLOROPHYLL FLUORESCENT 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44917:SF1">
        <property type="entry name" value="PROTEIN HIGH CHLOROPHYLL FLUORESCENT 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Suppressor of forked" evidence="7">
        <location>
            <begin position="451"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="602"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="716"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1954539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="792" mass="89978" checksum="A4B7694A5F7B432E" modified="2024-05-29" version="1">MVAAPLPRDGSWSNNSNNSDNNENAKRKVRQKYKRKRIPATEKERRRLSYERQAQYEELISKSGDEPPSIWSFECLFPKAVWDEEVIERDLNEVKKRDAATIGKKSSRNQKQQQQQQQQPKSTERLKTSAIGASSMMRVWREPKLSSFILPYVMEDVVENTKAFLGDKTRDSTKEETAEAEAQAVADIFTPTVGPKPSPNATLSERLGAAVIETNKSGKVDLELTRMVEDRMYGYRRGTTSLMGADGSVQFREGVRLGNPLPVNAARLNYHAKMELRHHRTEEAQELYEEAIRIDPRNGRAYLGLAKCAERRRDYKLAKECLKTGIANSVSLAEDGTPDSGANPFLLQALGCLEEKAGHLTQAEALFIEAARSRPSHAASWVALAQLRTEKFRQSAMAGRVCYQTAARELEKAGKKPSSHVFTAWAAMEYKKEGDVRKARKLFHMALKADKRCSAAWLQLGCMEAKQENWAQAEICFETCLKFDKRNSRILQAYAIMESKRPESNSRKVIELFERALKVNKRDAGVLQPYALYVAELGDAESARDLFERGTKVNKRHAPVWQAWGVFETRQGNPEAARNIFQQGIWACAPLGGGQSGGYKCARLWQAWGVLEAQEGDYAAARRCFNRAVDADKRNIAAYRAWTMMEEELGNWEDARSLFEWALQQFEPGTTERKQMWQAYELMEQNANNPSGATAVYQRSMREVFKLQDIKEEKEKEAEEESLAESLKTVAEVEEKVDEKKKEYDVMQWDQGSSSSLKAESMESEVWMNKGSIEGKVPNAEMKKQRTQTQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYF7</accession>
    <name>A0AAD2FYF7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYF7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042057558" evidence="2">
        <location>
            <begin position="27"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="655" mass="74079" checksum="67EAB4DF9F718CD7" modified="2024-05-29" version="1">MRLACNLQILFSILFCSIIIRSVVDAQKDAKSIVRSQKKSIVRGESRLFQADQNLNNYFNRRRSLQKEGEDDKKDDKDDKDEEKEPTLDEDEDNNDEDEDGDVGDEDKDPPDEDNGPDEDITPDTDEDVPDTDEDNGPDADKDGPDKDEDNGPDADKDGPDKDDEDKDDKDKDDEDKDDKDKDDDDDEDKDDEDDDDEDNDGEGTSCSECACFATDDELKNAVRQYIDDGCSDSKKCDSVIAKEYGWPMGSWCVSRVTTMQGLFRDAYLFNDDISAWDVSSVTSMRSMFQDAYTFNQTLATWSTSSVTDMRRMFDGASSFNQELQYWDVSRVVSMRNMFMGASSFNQRLAPWDVSSVIDMTGMFQGAVSFNQDLSLWDVFQVTEMGRMFWGAVSFNQDLSSWLTISVRDMSYMFRGARSFNQDLSSWELSRVSDIKEMFFDASSFSQDLCAWGSQLRTSELYASISVFTNSACRYPSDPRFPQGGPFCGSICTCFGDKWELKEAIDAVQQGSLYCAQVAENPSARCVTNVEVLHRKYGRSISSWCVSEVTDMSFLFKDMDTFNEDISSWDVSSVTNMEGMFQGASSFNQDLSSWDVSSVQNADRMFDGVTRMSTTLACRWSDTWNRAVCNGSSANTKSKLWALLLVLWTSTMVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZP1</accession>
    <name>A0AAD2FZP1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001959">
        <property type="protein sequence ID" value="CAJ1957998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1957998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="130" mass="14993" checksum="2FE3ED72987C874D" modified="2024-05-29" version="1" fragment="single">MQTFPPRTLDAILQDDVSKTQSAFEKDILRNYLLAANPALLPYIRDAHTTPLGLVDACHEYRKPRIIFDATHHPSLTAMAVNDFTSKETEPEICFPRSFPNFLIWIYNLRITYPKEEIYICDDDVSGAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0E0</accession>
    <name>A0AAD2G0E0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0E0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="104"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="214"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="357" mass="39545" checksum="8DC0DA83FB94160F" modified="2024-05-29" version="1">MSVILVDTRSDSLTVSWPAAAAEQENVKYQLEYKSNDDSENADNDGFALLSDKLSQPQARKRNLTPGTDYFFRVKVVNDNNDAGCWMTHSEPFSCLNADQESQALEVPKVSHPGLNQTLHVSWKASAENTDAKYELQMRENQGGAEWKTIAPSLSGLEVKKKNLTSTLGYQFRVRTIGGEIETPFSPPSESMVARGLSAGIRRFFGSLENGTLLRSGQKEPVPLADALGGKEFVLLYASAHWCPPCRQFTPMLANWYKSASNRIAGGGRAAEVVFLSCDHDEDGFQGYFQQSHPWMAVDYDDDARDQIMAAIRVQGIPRLVVLSGKNGRILVDNAVGQPLDVNKWRALEKQQQQQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0M3</accession>
    <name>A0AAD2G0M3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0M3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011735">
        <property type="entry name" value="WlaTC/HtrL_glycosyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="292" mass="34064" checksum="972E03801165D650" modified="2024-05-29" version="1">MKTIKAPTSNSMDGKIRSNHTIITAYFLVNKTKRHSDSNYIELMERLFSNSDPMIIYTSPEVAPLLAEIRGKPERTVVIPMNLSDTNLVKRYPRPAFWESVSKDGRGAGINNGYDYNLYQIWNSKVDFLKLGSDMNPFQSNFFAWMDAGFVRWDEYTNSTIIQRIPPELPETKLAIMNITPIIHFKTHHQMGGGTFGGYKPAVDLYHAKYYEKFHEYANSTDRYTHVSNEQLVLYETCRDNDGLCFTINPRKSNNNAISWGLQVPYFYMLPFFNTREYEEMEEKNFVDKSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G136</accession>
    <name>A0AAD2G136_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G136"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041931981" evidence="2">
        <location>
            <begin position="25"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="296" mass="30641" checksum="AC93BA379699FB0C" modified="2024-05-29" version="1">MRITAAQLASCLLVLTLSISSSNAWQSSTTPNNSNFRRSIHLFFTSSSNRYAQPRATRLQQTPKQQEDQKWSERYEHETHYDKTGGACSSLMKNSRRHFVNSAMATFSTMVVAGATASPAFADGAPAPAPAAPKPPAPAAPAPAAPAAPKPPAPAPAAPAAAAAPKPPAPAPAPAPAPAAAAAPKPPPPPPPAAPKPVPKPSMFAGSYTDPNHPGGKVAIKPTGQSVGDYCLAEVVGGGGQNEPASYTLPAVIMGERTIFIDFTSKGGPRNFVGFLNKDGDVDFLKDGNRWSRVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G175</accession>
    <name>A0AAD2G175_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS17967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G175"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1959546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="214" mass="24202" checksum="6578E61F04C43CD4" modified="2024-05-29" version="1">MLVLQQIRQQVQVRQELLVNGVVGGVLFCASDVLAQRLEQSEPQSIGKRKRDDETVSPMQQLRTIDREFLRSVDWKRSSSAGILGACLSCGLYPAAYGAIDKIWKRKDFVSLVQKSVVEVFTVGVVANSLSMLVRGLAPARSTSSNHSPLQVFTHMKAELPKVTIDDFKLWFPYNMAAFTFIPTPIRPLTTMLMETIWQTYMSLHSNNYEHHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1C1</accession>
    <name>A0AAD2G1C1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1C1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="322" mass="35766" checksum="D92235C219316C0C" modified="2024-05-29" version="1">MNKTSPNNKIMDNAEPAKIHQSSDSNNMDLKSFFQKLAQDNGVKGFSLVTDHAVCQRHDVKRNSAPSVFNGATRKVLSSDAAPSCPRRRISDGDCEQTSKLLFLETIFDEVDSILHEDEEGNDDQSIDSRDLSNVNHVAQGNNEFESSFQRFIAEPLGDESRESSSRSSASLREQLVAPRLPIRKGSISEFGGLRATRTLSSCSFNTACTTAESSLEDSPMIAPQCSIELSCPASPSLQAHSWQRKEGDDYECPASAPTTRHVLDMKEIFLSPLRDSGSSHGRRRRRRSSRRNSLDTGFTFRSSFNSQCFDETDGDDILWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1F5</accession>
    <name>A0AAD2G1F5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS18076</name>
        <name evidence="10" type="ORF">CYCCA115_LOCUS23494</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002417">
        <property type="protein sequence ID" value="CAJ1968989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1F5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="43"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1959657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1968989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="596" mass="65128" checksum="2FBDB0BA69A5A53A" modified="2024-05-29" version="1">MTTTRLRHHHHHHFWSLFVTSLICLLISNVDARRNQRQQQPRIVGGTNAKPDEFPYFVQMGKCGGVLIAPGIVLSAAHCMEIFRIGVYVTLNPHGVKDLSSKRLKIVDRYFHPWYWDEWASYDFILLRLEEPLYYNDDSLFLSTETTTTTTTTTTITKNSNTNTDIDFSVNLDDAFPPDNVTLTTIGFGTLKSGSNRFPDILQKVDLTSMNLDDCNATLEGELLDDSFLCAGTYEGGRDSCQGDSGGPLLYVRGNVHILVALVSWGEGCGDAGIPGAYARVSKAMPWIEKVVCDCWNVQGAPFCSQSIVAADQRQSLNNNSNNSNSNNSNSNSSNNKKNETTTLPPKEGGGGEAEEFECPLYIDPNCQDTPGYVDYVGDVCAWHEVEENPGCIWYGESPGGPGFEDSNAQGECCWCGGGSIIVDKPKSPPIKFERHPECIDLKDWNDLYGDDCAWFEANTDEGTCSGWGTIRGGAGMRDITPDEACCHCGGGIFPTPAPTSPAPTIYVAPTESIAPTQTPVPSLEVVYVENPTQQPTTATSPPAKDSQAPELKDDGLSDSSSATSSSMRRRRMMMVVSSTMSMMMMIPMVIIAIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2V7</accession>
    <name>A0AAD2G2V7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2V7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="403" mass="43265" checksum="BA7CC8227F85A55B" modified="2024-05-29" version="1">MSDEVASPPPKEAPPSNTTDSAAADGGEAKDNSDKGKGGGAGRGRGGRGGRGGRGSRGKGNRGRNNNNNQDSGDKDVTKETETPADAGSNEGGGSPRKEGGGSPRRRRRNNNNNNNNRNRKAGNKGSDDKGADETTAEVKESGDGEDAKEADKGSNNNARRNNNRNRGRNNNNNTSNNRNKDKGKAANPDDLMTELEETKKKLKESERMEILYKKRYAQLNEKWRDLKGVDYENCIVVAVPKTGEGTTEATETTTPPTTDAEKIPVLEQHIANIELELGKSKADLLSANQKLEQAERIAAKNKEQYSKLNEKWRALKAGEKKDNTNAKKGEKTEVGKPGEQEGTVVEEIINADKEGEEKPTEKEAVVAEGSANAEETPDEDKGARPEVAAAPGSADVEETFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3R3</accession>
    <name>A0AAD2G3R3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS19332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3R3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12362">
        <property type="entry name" value="RRM3_CELF1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="376"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1961709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="555" mass="57894" checksum="F6CF903E2645564D" modified="2024-05-29" version="1">MPVSVIPVGATVVDHHPYPGASGLEGMASTEDNVADVVTPPSSHDGKEPEQDPVVAPTTGEEGSVVISDTKEDKKGSPDRVSNSPVQSVSGYPQALPAHLTPQPQAYYYSQTQVTPEPPSPAGATGYDVGAFLQPAAYPGSPFGTVHVHPYSTAAQQPPNSPSHTASSLTGVPPASPLFPTLSGQPTHGLLDHHHVFDGSMQQHAPGSPGPHYLSSSGLGPVPNDFSGWTDNRQNSYPPNSPAQQGMPMPYVPGMPPRTAAGRSYSFEETMLAPSVDSQQDQGYGVYGSSPNSPGGHFSHHQQAPQWGYPTPDMYGMTAVSPLQPRPTMSYPGMPGGGGRGVPGQQMANYGGQYYPTASPGPPIQTTASNKGPDGANLFIFHIPNHFSNMDMYHLFSPFGTLLSVRIMVEKESGRSRGFGFVSYDSPDAAAIAIKELNGYTIGNKRLKVQHKQIRSAEQQNERGPNGGYNPQGGNQGGAGGNQGGRAYMPSSLPPSGPMAMSAAGGWYQEGGAGNVEGGAASEDVVNEPEDGAGPSSFSSMDPLRQSLPEVDGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G497</accession>
    <name>A0AAD2G497_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002000">
        <property type="protein sequence ID" value="CAJ1959457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G497"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="241" mass="26942" checksum="E66946B51297E03A" modified="2024-05-29" version="1">MVSKRAISTQNVRRAKSQEGPRADSRHGTDPQRRSFLSARSLDERRSGRSAGSNISRTVETFPFFSPEAAAGEIAFCKFKASCRRSCGGVMELEGKADRRSLWSVPLHDDLMGRMLARLVGNDGFMGHKVVNRFGRRQACRLSDVRQNRNPTLSTWKTRVGRMCDAPRAKKGQERTVAMELTHRGGLSSAQEAWTKEGAVAALDPTSAAPWRPFRFSRPRRQLERLLFANSRPVVVGRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5T9</accession>
    <name>A0AAD2G5T9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1963962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5T9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1963962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="20889" checksum="FBD452D4368962DA" modified="2024-05-29" version="1">MRHNFETTEAFAYYHHISSIDIAELFKMKLVAVSLMYLAVANAFAPTRTPSHQRSSSALSAALPQRDNESPEKKFSLGAPVVGLVLGLSIMTSAAFAVELDFSLPSYDAKMSGFGEGTEAILNKKTSDLTDPGANEKTKQSEAAMKAAIALKEKRTKEQEMKKLQYEADKQRAIEKKARDAERLKSIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G771</accession>
    <name>A0AAD2G771_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Atg6 BARA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS21003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G771"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="192"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1965211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="364" mass="41075" checksum="D753B2A873D03018" modified="2024-05-29" version="1">MFKRCLNPTDKMMVDEIYNEKDVQRLRDKLQQMKQKRQQLQALRSEVSKCQEKAQHRVDELYLERQHLVEELESIFKEKRAIHEFLELSDKWNVINDSVHIWHQGPFATIHNCRLGSEAPAISPHPPTEAMRHKQQQQRQSAPTTPPRGGWNLFGSSQVANDPSPPSGNRTASSSSDVSSNGNGDNSHVAAFSVPKVTWPEINAAWGHVVLLVQILAQRSQTTLPHTLQPMGATSKIYLNGDANSGILYSVHFEESSLWGRSNLRNFHIALNGVCDCLWQLAQSQTDKTVAVPHHMVYDKTQAYWKIGGVALVHLNQTSNNNNNQNGSPPNGNQAGVDFTRACKYLLTNLKWLVAYSVKHHAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8D0</accession>
    <name>A0AAD2G8D0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS21401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8D0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="70"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1965809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="488" mass="52846" checksum="7A671BD2F3E26E21" modified="2024-05-29" version="1">MQQPLSSDGIVRDSSKQVDEENRNATTSYRKMENADPNYPLEVDKDDDVSMAMSIASSVMTADGIEDPTGFAIVCLAILIGDMSRGVMFPSLWQLVEALGGTSVTQGYAVAAFSFGRILVSPMFGTWSVTHGYSQTLLISCSILLLGTLFYAQAQNVGRPEFLILSQTLLGIGSGTLGVTRAFVAEVTATRNRTTYMAWITAVQYAGFTVTPFVGAFFNKVLEDTDVNIGWIRINMFTAPAYFMSITVALTIYMLLMHFQDRARSQNPKDIKKMSAKRAAIDDHANQMTMVGLSIYDCCIVGCMLLNVATKGSIGCFETLGISIAESLFGISSTMAGTIVGSCGTIGVISLLSMGKISQFLSDIQMICGGMFVMAIGILSLTFVEENGDNPSWVYMLSFFLIYSIGYPISHTAVISLFSKIVGRRPQGTLLGWFASAGSLARLVFPVVSGYVEHYLGIVTLFYILTGVLGVSTVVTLYNQKTLTMLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8S7</accession>
    <name>A0AAD2G8S7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8S7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="538" mass="58053" checksum="AEA2AE99863D1D37" modified="2024-05-29" version="1">MMQEEDVTAAEQVVPNTAEEKKEDSETQEETSTMTGSLSDEGVGASETSIADRIEKTKDMMKDFGNTVAVEKPKQMFADIQGMASNLKERVAFSNKPGDGESDETGEKVDPMEMPRQLFAGMKEKASSFKVSFNSLADGGASSASPDGETGEKVDPMEKPRQIFAGMKKNASSFKGFSFNSLSDSGVTNPSSDGGTGEKVDPMEKPRQIFAGMKKNASSFKGFSFNSLSDSAATNTSYDADLDATSDEQAAVEGSPNDALERSKVFFTGMKEKASSFKMKLPLAKDEEFDEYGKAVPGPLDRMKADMKDLASGIRGKMASTNSQGSADGLDDGTPGRSSVFTISEDHEENDYDKLAASNRSVDMLSSSHRSMASNDLSVKVSGFINSAKHSAHDSLSSMPSLASFYASDSSLQSFGLSDRFSSFRNKTISPISEKLGFKHTKEPESEEVQFFQSTTGDKIPVGPEPTIVKELCPEFKEKKTSSAKHWENVLPKSTNDTRPSMARRLPSIASLDTSAHAPSPQPYEHDTSSLTISENES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8W4</accession>
    <name>A0AAD2G8W4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS20479</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8W4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051305">
        <property type="entry name" value="tRNA_2-thiouridylase_MnmA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43052">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43052:SF1">
        <property type="entry name" value="TRNA-5-TAURINOMETHYLURIDINE 2-SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Fe-S metabolism associated" evidence="12">
        <location>
            <begin position="90"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="14">
        <location>
            <begin position="435"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="13">
        <location>
            <begin position="516"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1964114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="650" mass="72752" checksum="5A6A645DEFF335D6" modified="2024-05-29" version="1">MNPLLFTSAFLKSQVPGASSLHQRHLPPSSCSYERHCRYVGNRIFLSNEDAELCTEGQETVEQIQQRLAQLGMSWKQEIDFHNEEFRSIDKKDSKVPGCVATVHVWAIGDDDSGLVSVRGNSDAIVSKGLLNLLSQHLSTKTVEQVLALDPSTITDQLGVREALSQGRNDGIANMLQVIQKQLSSSPESSLLEETADAAPSTNHQKTTVNGQAKRVALLLSGGVDSSVALHLLLQQGYSVTPFYLKIWLEDELAHLGECPWEDDVDNCQQVCDHAGVELEIISLQDQYHERVMQHTLNEAAQGRTPNPDILCNSRVKFGCFLDYLADERTGEFDFIASGHYAQVQRTKEASPLNQADGDEEDSETVRLRRAPDPVKDQSYFLCALQQFQLQKLLFPIGHLEKWQVRELAEEFQLPNRHRPDSQGLCFLGKVKFSDFLNIHLGEKEGDIIDAFSGEAIGRHKGVWYHTVGQRKGIGRSLFPLATAKGPWYVVAKDPKKNVVYASNQYDEEIFTQSRSEFHVENIHWIAGEPPSNDGDGMTFQFDMKIRHGPRLVVGSLELLEDNDGIIKLAQKDGGLAPGQYVVFYHSDDANCLGGGIISERHWAKFLLDAKERRTSDVDPFSKSNISRPLKELSARGMHFYSRKTPQSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA45</accession>
    <name>A0AAD2GA45_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protease Do-like PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS22145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA45"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041517">
        <property type="entry name" value="DEGP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046449">
        <property type="entry name" value="DEGP_PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45980:SF9">
        <property type="entry name" value="PROTEASE DO-LIKE 10, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17815">
        <property type="entry name" value="PDZ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Protease Do-like PDZ" evidence="6">
        <location>
            <begin position="352"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1966561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="518" mass="58067" checksum="3D1A3A5E1A47F88D" modified="2024-05-29" version="1">MSSVIGKRCVCRVEVSRVEWNFLHPWQRTPQSKSTGTAFVIEGKKLLTNAHVVRSATDIRIRPHGSTRRYPAEVLYFGPDFDLALLKIKGEQEEIDFFAENGKDHICSSGKEPDAKRKKFLHGLQFATDLPALHESVHVVGFPTGGNTICVTEGVVSRIDFLGFSKSLMLTIQIDAAINPGNSGGPALNSEGLVTGVAFSTKSHKKNQPLSNIGYLIPIDIVKNFLGRCQENPSTYALSPIIPYRFHSLENKSLRLAHAVPDTVEGVLLTSVCDSMKGFLAKGDVLTGIDDRKVSNDGQVQLRGDETIQHGYLLRGKFLDEQVRFSVFRNGEHVISSPAVLRYIPTICPRWESVDYFPDYLILGTVVLLPMSTYLQCQKGCGTRLSASTTNWCQKWPHEWEGKEGLVVLTEMFSHEVCFGYNRPYWRFVETYNDIPIKCLAHLRDLWEESMEQAKESDDRNGDSNSAKTFSFVRLGLEHSDDIVFEVRAAIQAQADILKQQHIPCPSNITQSNPRYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBG8</accession>
    <name>A0AAD2GBG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002380">
        <property type="protein sequence ID" value="CAJ1968407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="393"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="480" mass="54300" checksum="9AADCC57A4CF3FCA" modified="2024-05-29" version="1">MASSPLSELSARNQKNYVNRACFGLSVTSRPIAVSSEIEAAEGIVAAELNGLSIKERDSASDDFNCVGQGQEDDPEMICNALEKFEEEVRKANHPVYKLAVMKKNPNVQDSEYRLRFLRGALFDVKKAARQMLSLLQYQAEYFAIDALDRKIALSDLKEEEVKLMLKGLCHFSTQTDRNGRYVAYCLSNVFLADIPAEAMIRACMYASQEYGSFPDLDKRGLVAVYMDVGGLDQSMQLGPRHFNWVFNMIKFYLALPFTLSSMHYCVNIADSNSVAIRRNMIGSFMKALPRYATVRTKFHYGSALEIRYSLQSHGIPLGTYPIDSNGQIRQEMIDSSCLKHYGIDAFKYRGKSDSFIKSNDTAIAMTPVPPTPTSSQQTRAGHSVLVEPKHTDVLLGRGKPIQNHPGNIHLRSMIEESQEQYDAIGRLEKRQMIQNIRHACHARGTRFLKQHGKKTWVLADSAEADEKIRQHFRCCRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC46</accession>
    <name>A0AAD2GC46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1073" mass="119881" checksum="3CD29ACD95C6A9BB" modified="2024-05-29" version="1">MNSDELSSERRDCPPSDFQRDALPPAEMDHVMNIHDPINIKPRSAPYQHHSHGQYSYPPPHYQYPGSRHPIQSVVTTSFSTDEQDREDRSAFRPPYLPAPRNSYADYPPHDGRYFERTASTDAGAPYQYRPFEGHNIDSEQMHYARELPPIQEADVELRTPPQEVIVPRSSMRVPPSPREQPPPPFGARPEGIPPASSFHSDGPLKRSFWHHARPTDEYHQGPSIPNEFMPPKRAKVGTSGGGRRELLLAPSRTFSQEFTDMPASAERDTRSRGHGGWFNRGMSWDTRDDHYSRKGNGSEIYPSHSWNRSPQREGNMMQHWDTPFALSPRNRYPTGEGGRYELAQGHSWSPKWHQHDDQRWGMPQNRDDTEAMHFGPPMEEREAYERFRRQGTFDSRSEPEPPVRYINAPAMPTHASPNYPSTPLSHRIAPPKMGDAPFLGATSDMQPVSSSQTKGPIRLLALSGDRVTLSETLCLVRENIEVFTATKEDVDAPAPGRKQAIVVGQVGLRCIHCRHTTKSSERVKRAVCYPSSIKRIYRSVIDMKLDHFLHCKFVPVSLKDRLIALKANNTRSTGTTMQYFIKAASSLGMVDASSGVRLTEIAPGLSPPPPPSSSENAKHGSPRMETEKDKRALIAPMSPLSPPQIDRNNSLSSEGTESAGTVLGEDDLPEAFTGCVSLAIPEDEKALSPLRCFLREQVCAFSATEEDIAVRTPTTFSVSVGQVGVACKHCLKEPAKSRLNRAVCFPSSVTRIYQSVADIQRYHLGECKMVPADIKEQFAELQQASSKGSKGLATRQYWINSAKRIGLVDTTKGIRFGRDPSQPAEKAFSLDILAQVASHVTTVNRPIVLPEDQPSIAEFIYVVMQQLQPCRFTEADRNKRRLKDVGCIGVECKHCAGKVDSRKFFWSSVNAVESNFVSVHTHMGECKHVPEELKEKLANLKKLRKEQTSALKTGSQKAFFSRIWERLHKEEQKAEEAEKKAEDVVDMGSNDVEMKSDHDNKMLEDEEEKPQGDSADAVASKSALSLHSESETAPLSPIPQSKETGGIDALKTPPLVSPSTDKLKDQMSMVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH14</accession>
    <name>A0AAD2JH14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS12169</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="23S RRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544:SF8">
        <property type="entry name" value="RADICAL SAM SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01062">
        <property type="entry name" value="methyltransferase_(Class_A)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="149"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1949582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="510" mass="57284" checksum="BAADB8902B1CB4D0" modified="2024-05-29" version="1">MGYEGKVRGRRKAPFPRSILDRPCFLEALDEAGISLKQVHVDAFYQALHREHYPSLPDFVKRYYENEKNVVVENEKPQRQKITKRKNRNKLNLPKKLLQFLETTNDFVTKTSTIKERHTSMDKSTTKLIIELYDGMVVETVLMRYERKGDGRASLCVSSQVGCAMGCTFCATGTMGLSGNLTTGEILEQLIHADGILAEEFGLREDKSKRVDFVRSIVFMGMGEPLDNYSNVVGAARSMMDRRRWNMAHGRVTISTVGLVSQIRKLTKELPEVSLALSLHAPNQDARTAIVPTAARYPIEELIDALDGHMTAYLGDRQNDKGITVEERIKESSRRRAMIEYVMLEGETSSFECAHQLGKLCENRHLVVNLIPYNSTDVRDKLRCPSNAHLQEFRDIVASYGSFCTIRRTMGADIASACGQLVKKIDKDERNEAIDIEDVAGPQNSLANKTKKGKVSTRQVKTKAAEPSSSSWIESLGEDELNVLENTLSVALGISASCFLLSSLVYFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHD8</accession>
    <name>A0AAD2JHD8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1949877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="387" mass="43542" checksum="356ED9C004914895" modified="2024-05-29" version="1">MAAVIQFRNWCEVDLLIRPVLTQHMTDVEGLDSVDSFANRTTSQVQEDIKSMRRAPNPNNANATIGVTARESMTIHRISKYGKLLILVQRTHTPALGTIQNLLFIGQFYDENPDLMEGDSNPLPPHPPKFNNRDGRIMMENIESWARTAYGYRGIRLDYIFRENSELPVAGDPGFLKADDGTRSIEEELVQRAAHTGAVFRRNNQKYWVMLHAVTHETDAYNHVRQFAPTLNGRAAYFALFAQYRGRGHFTNERQAAVRVLATLHWNGKAQGFTWNTFISRLIGAFNDLKLNGDPRSDANKVEGFTWNTFISRLIGAFNDLELNGDPRSDANKVDVLLEKTVGDSSLSNGRSHITGDAVLRSNFQGAIDYVTTQVLAAGNDNTQRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHR6</accession>
    <name>A0AAD2JHR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS13042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1951376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="52356" checksum="2677E7BE252D141B" modified="2024-05-29" version="1">MPQEPPMEEVQENSDCCKCTGFLGNSVARGMGITAAGRGAVIASNIFISSSLLYLASQEAGCLDEDGKTTECDEKIYGFQPSSLITNIAVISNVVAAVLNPLMGAVVDFTDHRHALGTICAFLIIGIQAVQVYTVSSTWFIMAILQSVAGAIYQFMLTSTYAYFPEMAEQLGEKAMSNIAPKITITQFSFQATFMVLIIGISIGIGSGDVLTAQISQGINAVILLVCWSIGWFKLLPKSKAKRTLPEGKSLFSAGFSQIFQTAKHINSHYKNSIRWYLLALVFAEAGANSFTICAVTYLNEVLKMSGTETGIVFLIVLVCTIPGSILCEYVVNKTNFNTGWRLNMLYFSIVTTVGVFVLNDENDKIMTYVMGVFWGIALGWFYPTENGFFAVLVPQEQATEMAGIYNFCALVISWCPPFIFTAMNENGIPLNYGLLHLVAYFLIAIALLSMMPSWDVVIAESHGPSSTLVENPTKPDATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI18</accession>
    <name>A0AAD2JI18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thiamine pyrimidine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS12922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI18"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528:SF1">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042285935" description="Thiamine pyrimidine synthase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="SsuA/THI5-like" evidence="13">
        <location>
            <begin position="46"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1951136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="342" mass="38003" checksum="A51707409068AB7D" modified="2024-05-29" version="1">MSSGFLLSILLLTVGSAYSQQCKADDASCTADGLTKIRLGLEWFTNPDHLPLVVAQKHGIFREFGLDVELVEPKDHWEAEEEIIAGRLDVAVTEPLHLAQDAAKGKPVVGFSRFLHTDGGILYDAGKGDITRPADMCGKTISYPGSPGPGGPAIVNTMVKADGKQDCDLDSYGKHNGGFFHTDALQSGKADVATLIFWNFEIPEAKAKGMEQASFFSLKEWGVPDFCQLVLMTTPDRFEERKATFRKLVLAMRRATGLIHQQPNLARSYYYDYVKKEEAEETQQDVIDATFTATLPAFPNDNNMAKEYYDHLMSWLIETNQVDAKKASKVEVSSYWTNEVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJA1</accession>
    <name>A0AAD2JJA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJA1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042292537" description="Glutaredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="165"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1955519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="253" mass="27655" checksum="248CBFC12B563E37" modified="2024-05-29" version="1">MRLTIRNTVLLALIGCMMSPEVNAFTSTTKSSANTDPAVRLYGMKRPIIDQVASTLFQLETSRVEASSVVDDQGRKGEPMEWSESDSIANRFSQIVQNNELGYRFKQFVADIVAGQEYDHEATIKVIDEFVSSTTTTSTNNKQQPSIFGNFFAGAGGSRKGAPPVAMFSFTTCPFCRRAKDYLDAQGIPYVSMELDELPGNQGNEIRASLGRKTRRTSVPSIFVRGEYVGGCNDGPGLLPLGESGELQRILEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJR0</accession>
    <name>A0AAD2JJR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS16534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042092129" description="Circumsporozoite protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="773"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="656"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="789"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1957076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="820" mass="86266" checksum="EF0DF3C41181CB12" modified="2024-05-29" version="1">MVKIMQFYSICTFLLMWHCALGGTSNERTAFNSRRGVSGDHSSSSADYFEANRIFERVVYVDIDAGEADLAGLSLVSTSTLEHQFVQSFNKLSEELCDIEGLRILAANIQYTDASKTEYILRRGGNKYTIEFQVFATCDNCNPFSVTVFDHRVLTTRRTREIEGDVETVFDRQLSSKKSSKKSASNSSSSSSSSSSKKSGKGKGKGKGKGGKGSKKSGKGKGGMVIGDKAQQNGQVICTAKNPQFRAPTEEEFREVYSVAVRGLMTGSTTRRQLGRNFVVGGLLPIQAITKVYEVLDGRCVAAFEEFNSIVTIEVSGNFEAATTAEYLELAEAFFQNYNALQAHGCDKPLFREVSAVEITMATPDTDGNGFFNLVLNVFASCQGVGCTDDISLFSDFNVFRRLLTNTTLEVDDPCECPVSPNRKNAAPSALEMGILFDETLQELRASGLVTNFQTARIITEVGVQAISPAPSGMPTVSNAPSISNAPSTSVKPTGGPPTFSQSPSALGSARPSVSFAPSNSMAPSLSPTISNKPSVSLVPSSNPSLSGAPSGKPSDSAPPSQAATTSVSPSGAPSTSKSPSEAPSGSGAPSVSEKPSSNPTNSLVPSFQPSNKPSVAASGVPSTKPSLAPSITPSSNPSASKQPSSQPSFKPSKSENPSLSVQPSLNPSGSDNPSASIQPSMNPSTKPSLNPSQNPSTQPSNNPSLSLNPSQKPSTQPSLNPSSIPSQNPSAKVPADLDEIDNSTPDFDKPPDNDIVFDPLAEEGAETAVLAATDSPTMAPVEPVEPVVADDDDAGDDDADDDDADDDDADDDDSERRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJW5</accession>
    <name>A0AAD2JJW5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="369" mass="42469" checksum="E6650DF3738931F2" modified="2024-05-29" version="1">MRNVGKWQGITRIHETVLKPKRARSNKRTKLSHTPVSEPIDTTQTPTPESNGENGAPVQESMGAHSIDRNGQDRLGQPERNGQDRLAHDRNGRDRLGQPERNGRDRLAHDRNGQDRLGQPERNGRDRLAHDRNGQDRLGQPERNGQDRLAHDRNGEDPMHTQQENEQLIQRETPASSQRETQSDPQRETQLFSQREDGSASQRETERVSFQHPALQGTVNSQTQAIQALKAHKSSSQKRKRGREEMEETETATSLEEHRREMQLTIRCYKTEIAREVHAEELVEQCMTSNPFAFAATLADEDTMYLNQAKKEPDWVQFHEAMVKEIQDHTEGKHWEVVPRSSMPEGHRAMRGVWSMKRKRRVGTGEVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK90</accession>
    <name>A0AAD2JK90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS16208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="102"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1956387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="607" mass="65844" checksum="8BA309AA753C295B" modified="2024-05-29" version="1">MINWKTAPLRKRHHQSSSTNQTLNSSSSPEDHHNAQDQSNNNMSTRFDTISSEMSSTASSATAPDTTATSRLDDFLQEAYNISSASAHHQKPWQTQWKYWSIILSCGIANSSDASEILCLSYILSDETFTDAILEHSSWKGGLLAAAVFFGMLVGGLFIGTLGDWLGRRPVLLVGLACNSIAGILSAMAPNVYILSLLRCIAGVGIGATVPPLFTLVTELAPPSHRGFCVTLVASFWMVGSIFVALMAMLLLEHMAVSWRVFAMACALPSLLGFVLCKELVPESPRFLALEQRHEAALDVANFLAQRMNSDNSIASFTQAPLTLEELQQAFPSRSTNSPLPSHPLSESLSCRGMVTMALNDFFLSSRQLYTPQLRNTTWPLQMVWFSLSFGSYGLLTWINTLFVQVHLKNVYFNALLFAFSNLPGNILTAVYMDKVSRGKMLTFCILASAASLVGFALGAFSLNSFLIVGSACTFQCFTVAAWNTIDTMTSELFPTTVRSTGMGVCAASGRVGAMVAQFVNGALVTKPVRLLLVASVTLVLGALTPALLPDGGDMTGQPVHDFAVDENSPTEKISHEPLIQQENQSYQDDPNNDSARSEGSSSYRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKE9</accession>
    <name>A0AAD2JKE9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKE9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31807">
        <property type="entry name" value="AUGMIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31807:SF37">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="787" mass="82507" checksum="FC49397017AD835A" modified="2024-05-29" version="1">MPELGEKLRLMNGSSHHSTESTSSSSRQHRSFSSSSARRHRRSSSRSSSKASHLTEMEDKMERMQPPSDSPSPSQESSPITRRSSSRRSGSSNRRSGSSNRRSGSSSRTQSGSSRKRSGRSSTRQRDGSKKSDDALSLPAGVDPNLSDEDCTPGAHRVGSFGHVSTLSPASFEHNESTDDQSFSTASRSSGTSSVGAGATIRSSTTSGTTLAPSTLDSVSEHKTMVQAVVAKDYEEELEAARAQGRQEALQDLTSSHTRQTVTTGDLAVAVAAPDDDEKSIDPAEVQRKKKKKRRNMILLFLVILALVVTATMLLVGGGSDAPDQLETAENSNAKVVVVYNPPTQEECQAIANGTFLGDQQSLIQRSFDIRIDMTLANEYDFGALYSAMMNHIQEKLIPIMAGCGAIDFFDTTMAISDELKNTTNSIVNGQVSKQSEEECVQGSENCKSYILVLDLYLKEEQSSASLMEVISSTVTGDELANTLGSIVPVQSASVPWIVPSGMEGATVTPTASDLIMIVPTTTPTLAPTKSLAPGTTANPTVPVIITAVPTQSPDDSDVAPISTMAPTLAPTITRPLATPGTTPAPTTSKPTTSFPNLFQPTTDPGLSSPTNAPIQAPTQGPDSNPALSPSPTRRLTPAPTVRNPGGPTVVPRNPTKAPTINPTNNPTKAPTKGPSKAPTKTPTKTPTDAPSSSPSISTPVPTVAPTLAPVPAPTEVPSVAPSKAPTPPPTLPPTPPPSPLPSMAPSTAPSLAPQNCCSTGSQVCDVTNPLCQLALTCITTCFANWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKH6</accession>
    <name>A0AAD2JKH6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001982">
        <property type="protein sequence ID" value="CAJ1959255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="40830" checksum="0E341D026AACDEB0" modified="2024-05-29" version="1">MGGLAPNVCEVPPYHVVQTNEASVPTYHEDFLEMYIQMAPLDGEAFTMDNAKVLVLLRKYIVGNTQAEATIRAINVEGKGRDAFIALRTHYKGEGLLAHDIVEAENTIKNLYYVGEKPTMNWAMFERMLKKAYAASDKHEGRVVHSEAMKLRNLQTKVTASFLQLNKTAIDTEIGKRPMVMNFTTALRIYRTAVREKFPQGANNATDRGRHLGKARASNNRNRQNDDRSRSQNGGGRNRHRDEEEITLSNGEKIWYRPSYHFPRDQLRAMTDSQQERMSNERAAHRAHQGMPARQTRQNTTETQLSELRAEMASLRSNNVPGAVETGESATRISQVTMGTGGISVMGGRNQQASGHNQQAGGSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKM5</accession>
    <name>A0AAD2JKM5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF7">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="476" mass="55190" checksum="2A3937A52015FB06" modified="2024-05-29" version="1">MVVLTNQKTLVRTDRIILQRLFIASAVVALSVFTIPLDLIESEEDLKHNPKFLRNSQPTSGSQWASKQNIVPYESKYHVVFSTGCSNFQDWQSYVFFYHVLQSGQEGHVTRIVSGCNESQKQELEGIFETEVASLAPGRFHLHHTPDYSRIKQRASYVYFNKPYGMRHWMEHVLGYPDPSEEQDDDIIMLLDPDQIIKRPFTAEFKREAEDWKTEPESLRVDHGSPFAQVYGFGLRWKTQIDLAYVFQNLSTPITSMTKSELEDYYHAMGPPFIATAKDMYSIVKVWSDVVPRVHDQFPQLLAEMYGYNLAAAHLGLRHMLAKSFMLSSVMTYRIEAWEKILDPLPTERICDKNLPQESYPHVLHFCQRYGVGKWFFNKKILPKTLLSCDGPLLQEPPYNLVDLYSSAIYPGVLNVIPLPMSRRRHESFMLCNVIRDLNLALVHYKQQHCASANYEYNLTFFENMTWVDNTTLVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKQ9</accession>
    <name>A0AAD2JKQ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS17992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKQ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="612"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="629"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1959571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1271" mass="138055" checksum="31D505AB585331DF" modified="2024-05-29" version="1">MSTTEEKGSDNQRRRKDRDRQEEDAKAKERGRRNKKKEPSTASGGQSEKEGDVDKPRSRRGERRTQEEREAKTKASSGRVSSSSSRPGVSHEKNNSSGRTRKKTSEALTSSSGNGQASIVSPQTRSSRRSGRGRGNDKKGYRNKGSSTPGAQAESIASPLFSSSRKGDGKKGYRNQGSSTPGVQAEQSDHDRASRKESRHKRNTRGVDMDVTIAPNDDEACAVHASIVGEEADVVVQGQTDEDIRKMVEAEAKRLREEERQQEERLRDEERREEKKREELLQAEKKRKKKRNVVILVVVIVLICGGVGAYFGTQSSSSGKSIDGGDAVALDDGNNQNPADDTTSDSPSSDPTIAATSPPSQAVFKYPPPDLEDCQRLIDRDPPLDEDGTLENREFEVEFDLGLSSAETGISTVLAEVERKIADWLLPSLVGCDDLQRRKLDGQTPASKGIRGDTVRRLQTTSEDPLRYMIADVLDIRAVDQEEECSFASDIPNCSFVKVKMNLLLRGDERNLYVATLLSDFFPEGQDLKGVIGLSDDIAIFATRRIRATGPTKPPSAMPSREPSVSPSDFPTKEPTIPPIPASANPSALVPEPTKEPSESPSKTPSATPSSAPTPTPPPTFAPVPGATPSPTQTPSATPSSMPSAAPFIGSTPSPSKAPSTPEPTSPPIVSPSTDPSLEPSLSPSGEPSRLPSAQPSIQPSMEPSLSPSTHQPSLSPTIPCFQSNTELSDAVSNWFQSKATVEAQYGLMGDWCFTAGVTSMQNLFLEKGAFNEDVSNWDVSSVTDMSRMFNGANAFNGDLSSWDVSSVTDMEAMFANNPSFNLDVSSWDVSSVTNMESMFHNSRSFNQDLSSWDVSSVTNMRLMFFLASSFNGDLSSWDVSSATTMESMFRNSRSFNQDLSSWDVSSVTNMRYMFFQASSFNGDVSSWDVSSVTDMALMFNGASAFNGDVSSWDVSSVIDMNALFANIPLFNQDLSSWDLSSATNLQSMFSGATSFNGDISSWDVSSVTIMQSTFNGARSFNGDLSSWDVSSVTNMDNMFANHPSFNPDLSSWDVSSVTNMKGMFQLSRSFNQDLSSWDVSSVTNMALMFREASSFNGDISSWDVSSVTTMAGMINGANAFNGDLSSWDVSSVTNMEAMLANHPSFNPDLSSWDVSSVTNMESMFHNSRSFNQDLSSWDVSSVTNMRYMFFQASSFNGDVSSWDVSSVTDAYGMFRGATSFDRNLCLWGLRLSANAVVSNAFSTASSCQSQSDPDLSTNPPGPFCYACILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKV4</accession>
    <name>A0AAD2JKV4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKV4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="808" mass="92785" checksum="A33B80D0D06FC33C" modified="2024-05-29" version="1">MESIGITPAVFLGNEQLHADEFYSIYCSSVPEYFIWHKEQRNRLQKHAEEWDQLNYYLIECTETYQKCGGTADRLGPLPFHIKVASETKRLLLIHWTKPAPLEEFLEPPSGGFDWRVPPWLLENLQQEIAKRFSTHEKQILKYANYTQARLLSVKFQSHDHGQGSYDQSRRSPEEPNFLQVYHDLWRVFFTPNPRIAKQIEQYMGDFQLQPGAYITVHLRALYAVEERQEDLVEWWSTNSINCATTKLPIHTRHLPLVFVSDSDLAVEMAAKQAHTMEKFHGIRVLHRPHATTPLHLEKTGNRTSSSASDFDDIFVDLYTIGMSRCTVFNMGGFGRLGSAIGYNSSCIFRTMATMIKCNPPQGMQPHLRGPQRELSSPLFLPPMMEGSTTAKSLNKSPNSSKSSGSNLPPMMDEPEVTQIESITQSQLLYATFFNTSETPNLWKASDKIPKWMKKYFRWHREQRKAMLNPENWRSMRLLLMECLDTHESCGGTSDRLKPLPSLIRMAHISNRLLLIHWTRPAKLEEFLLPPKGGMDWRVPNWLHPFLIGYSFESPKAVDPRPAIQSKHQSVSVRYQSYDAGQGWYDSEKKEAEATFNELYHDIWRVFFTPALPIAKAIKDFMGENGLFPGHYSSAHVRVLYALKTTPIPRIMRWTKNGLNCASHLRPGKPIFLASDSHQATQIAEEYAKKRNTTIHIHPNNPDPPLHLDKAEDVNDHSTPRRSPSDYYDTFIDLYIMAFGQCVFISKGGYGHWANLIGGNTTCIYKQKRAKSGIQNPCNWTFAADTTPHENLRITEALFNEPVLQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLG5</accession>
    <name>A0AAD2JLG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1961521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24507" checksum="48293B6B14379409" modified="2024-05-29" version="1">MKVLPNLFILFNLGKQEHSLPPSWAVSSATSLNLIATTKKNDAAAAAAVSSSVQRDEKIQDLLSAVSQVGQVGSLATEEERLKLEDLSKLAIPLSDSRPAQVPLLGEHKLLYSAAPGGSSGRLFGNAVGKVTQFFEEGEIFCNRVKFGPLQIALRAKREVKSDSVIKVSFLETTVSLFGKTVVQKEVGGGGSWKVKFIGKVTDENGKEKLIRIMETPSLFILEQPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLJ1</accession>
    <name>A0AAD2JLJ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS19282</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLJ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1961609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47720" checksum="D0DD2D2BFF162131" modified="2024-05-29" version="1">MSSYHPPKRDSMRNQIRTPALVQNRKRIVKHQEPKAVPPPPSIDEDTVDLGAIVIDNGTGSTKAGFAGEDDPRCVFPTLVAHPTSTFGPNSKAQVGKQAEAKWSVLDVQQPIDRGIIQNWDDMETIWHHTFYQLKASSQHHPVLLTEVPLNPKANRERMTQIMFETFKVPALYINNTAILALYANGRTSGCVLESGEGVSHAVPVCEGYVIPHAILRLPLGGKDLTQLLQNALAERGHALQDHIEKNFSDEGLVLTSTAVQVQVRTMKETLGYVALDFGQETIKAVDKSAALEKSFDLKDGTSIQIGNERFYFPEHLFQPNDLMGLEEEGVADMTFQAIMKCDELLQYDMFSNIVLSGGSTMFPGFRERMLKELTALAGSVEITINDTAGRANAPWVGGSILASLEQFNHLWITKQEYDETGSSIVHTKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMB4</accession>
    <name>A0AAD2JMB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1138" mass="126965" checksum="61EBA06B7B3C7426" modified="2024-05-29" version="1">MNYEMPMEQIRLSHQQAHLTSQEEEAGAYDTSPTITTLRDSSSDTLLSLIGASSTISAPSFILTYRIKAAISPGIGDFQSIEDHTRFFITEQLGKTFRHGGIGIAKKSFASIRDETNKPADSFDIVFVPVFLFDSTWSTIPSEVDVDKILVSMFSGQSLAEYTSSLSHLSPTNAFSTTNSVVFKRSQGVGLDNNEQKSSNTPYFAAACAGIITVLILFLWNQSMRVRSLMKRRAKGIETETRGKDEEAGNTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSVDDIFTYEVENSTSFEQQLPLHKSHSTLDSIFGGVKSRKKSSKTCHKSSDDESCPGKGESYSVEACDSSFEQISTLQKGHSTLDSIFGTQQDSRKYKLRTKSPKRWDEAPDDDNGSASGKRSSDDSTSTSEDSLIEETMEYTSGPEEVIVEKYSSRREVEGSDTERQNSITPSTKCEESIAITTSDSSQTTSLHAWLINQGKNKPLIGSNGLIESRTQNEKQTSSLFVYSYHGYQCSESTEVGDDLEPPFRYDNILRSKDQKRKPRRGDRSTGKARNATRNRKRKPEMDCERKGPSSSDGATQERHMNRTILLDELKQDLTTRSKEQNHPVSVPPKFTQKVTAGYNIPLCELKEELCRQPVSKSKPLPVPDKRVWDAGSRPSDFIYELKGRIASRVAEQDNLRPVPREEDRNVGRAPGGLIQELKLALANREKRVLNYDFSAAESKNLTRVFPDDQLMIELKQKLAHRHHRVRGSSVLQAQPSRECSEPVAQVSLSSVKEVQESIKERMDEQSSSCHGSKSTETTGTVDQMDCDGNMSTVSELGEHSAVFTNSSPSRNLQVENYGNERNELPLVVTTRKAMKKDRTADKYASKRRDDPFKELSRLNQILESQSDNESIATPVGANEAIESTFDLEDQFQKSSKYPWKNIGDRKKNPSTQKNQILVVDFVAPGKTPSDRGSAEMDLLSRYKEDILKERMKRKSIDRSVNGDQSISSIVSYKARLFPKKKEKPDNIPWWLPEETDSSTSSSSTVKQDGTIDESGDESSTDGDEISYGSSSYAATTSTSSSFFANLLKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JME9</accession>
    <name>A0AAD2JME9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002189">
        <property type="protein sequence ID" value="CAJ1964475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JME9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="132" mass="15496" checksum="7E48D5A6388FF56E" modified="2024-05-29" version="1" fragment="single">IKANSNFGQDDNSDYDEQGDDAALAFNVNQLCLQQPKELCQKSRAYNFQKFKDIDRNCMNQRDLDFVREQMEAIEKELFQRKAMAMKKSQKRTFLGATNGQQDMVSFSLNTETCKKSYQDTYHRKKRRKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN44</accession>
    <name>A0AAD2JN44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Photosystem II Psb27 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010207">
        <property type="term" value="P:photosystem II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010206">
        <property type="term" value="P:photosystem II repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.810">
        <property type="entry name" value="Photosystem II Pbs27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01481">
        <property type="entry name" value="PSII_Psb27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025585">
        <property type="entry name" value="PSII_Psb27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038450">
        <property type="entry name" value="PSII_Psb27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34041">
        <property type="entry name" value="PHOTOSYSTEM II REPAIR PROTEIN PSB27-H1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34041:SF1">
        <property type="entry name" value="PHOTOSYSTEM II REPAIR PROTEIN PSB27-H1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13326">
        <property type="entry name" value="PSII_Pbs27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042271206" description="Photosystem II Psb27 protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21371" checksum="8F4FA06FA9294C7A" modified="2024-05-29" version="1">MVKTQLLLSAALLASVNAFSAHQMPTNDVVAATSTSTTATTTTAGRRDFLKSASVAAAVVLATPTMASAVVEVPEQVTSFEYPKNWGLTYKYDEDAEKVRAHMYTATTLAKGAENMEDFGKNMKKEMVDFVSYYRRFPQIAGKPSFSTLYTSINVLAGHYTSYGYKYPLPEKRRKRLYQEYAEISKSLKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNZ5</accession>
    <name>A0AAD2JNZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF9">
        <property type="entry name" value="POLYKETIDE TRANSFERASE AF380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041910542" description="Serine aminopeptidase S33 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="3">
        <location>
            <begin position="69"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="350" mass="37630" checksum="37DF553A9BBB789D" modified="2024-05-29" version="1">MKWTLITAFLAALIAIAFTIAPEKPDFIPFSDNNDAESETTVRFVGGDNNTMLTGHWNLPSKSDGEAPPVILLAHGLGLIQGKSLSPFVSAFQEAGYAVVTFDYATFGQSDGLPRHQIHPTNHVADIQAAIAMINEEGTKRGVDASRIGLWGTSLGGGHVLMAAINSDPSIRAVISQVPHIASALETIIVGMMNLPVTTGKSVVKYLAGLLKWSVSKVVLRKESYFPIVGEPGSAALMQNPGDTAGYLGILNPGGEVSGGWKNAATTESGMHILFYRPLSSLSRVNLPVLLIAVENDTLCPAKFVQAAKERIKNAELFVFPNLGHFDIYDGEPLKTMLSKQIDFFNKYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JQ56</accession>
    <name>A0AAD2JQ56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002425">
        <property type="protein sequence ID" value="CAJ1969732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JQ56"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF281">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="2">
        <location>
            <begin position="120"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="490" mass="55634" checksum="60798F3E3FB34F58" modified="2024-05-29" version="1">MKSENLKMRMDCRLTIFTLAITFALSIFGAFQFTLYSVSSSAKRKINERNQNNGTVLIQLLSNRESTAVQSAEADMTVAGTDGESSTSNDNGMHNTPLLADTVSPIEFKKPTLKYFIIEPPEYTSSLLTDKNGVSDSYYKFALNEESAEIWLHRAFQQLIYEEGHTIDPSEADVFLIAGYLHLNLATPPRPELGNQTEMIQLYKDKIVNKTKPHLLLTPTWNPGRSQKTGVAPLTDALQKDGVNMWSVGIERNKSWQGLPPNRILPIPYVVQQSLEQRNDKSSLTDKIENSVFYAGDARRNAQGWAGCHREEMILPLKENSTLPNVDVRIVDKKNRLDQAEYNHRMITSEYCLILCGDTPTSRSLASAWVSGCIPIMVGSRLRGLCEPPCQARFGWAATGKEYPHFCFPDRIPWKDFPEVDESKFTLHGDQVLQQVFSQYDKAKKQELRRTMMQVRDGWIYGWGDPVTSTSFGQVHKYLWEEFEKLVLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVC1</accession>
    <name>A0AAD2PVC1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CYCCA115_LOCUS15219</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13 14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasmic vesicle</location>
            <location evidence="14">COPII-coated vesicle membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVC1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000005">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000041">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="17">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="18">
        <location>
            <begin position="132"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="18">
        <location>
            <begin position="375"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="20">
        <location>
            <begin position="443"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="19">
        <location>
            <begin position="570"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="16">
        <location>
            <begin position="684"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAJ1954625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="814" mass="89509" checksum="789D2763F19D77A4" modified="2024-05-29" version="1">MQEGAWDVSQLEDMSGTRLSFHCWPSSRLEAARCVVPLGALYTPLKKLPVSCAPPQAMPYDPVRCSSCHAVLNPYCQVDFRSKLWNCPFCLTRNHFPPHYAENITETNLPAELIPQYTTCEYELQNVPDQGPPCFLFVIDTCTTAKKELGELADSLTQALNLMPPDSRVGLITYGTNVSVYELASESISKAYILRGNKEYAPGKVGELLGCTGRPGQVAQQQPNGAAPAPNSPPVGPGQQVLERFLLPVSECSFLVESILEDLRKDPWPVPNDKRPARATGCALSVALSMSHLAIPRRGARVMLFTAGPCTSGPGAMVSRLKEEDMRSHADLAKKAEPMFQPACEFYAKLANPAHHNAPPDKKKKKAPPPPPTPSYHVVDVFACSLDQVGMLEMSNLVEATGGLMVLGDSFGQSVFKESLLRVFNRYPDDVPQDGGHLFMATGASLEVFTSREFKVSGAIGPVTSLNKQGPNVSDLEVGKGGTSAWGLGGIDPNTTVAIYFDVTNPGNSPMSEGKRRYIQFLTKYQHSSGKTRLRATTLCGGWHNPPDPPKDGAPANFGMQQSPVKMSFDQEAAAVLTARMAVSQTESDEVADVLRWVDRSLIRLCSKFADYRPDDPSSFRLSPEFSLYPQFMFHLRRSQFLQLFNSSPDEAAYYRYVLTRENTTNSLVMIQPTLLSYSFNGPPQPALLDAESVRPDTILLLDTFFQVVVIHGETIAAWREQGYHEQEEHAAFRSLLEAPQSDAILIMDSRFPVPRYIVSDQHKSEARFLMAKLNPSVTHNSNLDGGGGGAQVNTDDVSLRVFMEHLMKLAVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVJ5</accession>
    <name>A0AAD2PVJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042192481" evidence="1">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="199" mass="19958" checksum="4FDBF02A48953110" modified="2024-05-29" version="1">MKTISSLALLIALFLGNAAAFMTAPSKAAVKVDTPEESSTSLKYGYGMSRYGSPSYGGNDGWGSYDRMNSYNYNGYYGRGYGGGMGGYGGGYGMGGGYGGYSNIGYGSGYGGYGGGYGMSGYGSGYGGGYGSGYGSGYGSGYGSGYGRGYGGGYSSIGYGGMGGYGGGYGGSYGPYSSGYGYGGRGGSYGRYGGNWWDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVT2</accession>
    <name>A0AAD2PVT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS16626</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVT2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="91"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="291"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="455"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1957254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="56567" checksum="F7AE47E5AED9B5AE" modified="2024-05-29" version="1">MGSASKKKQIKSNVVRKEDVEVEAEEKKAVERRTNENEEPKTAQGSADEPDGEVGILTETSFASLGVCEAICEACDKLGWANATRIQEKVLPDALQGRDIIGLAETGSGKTGAFCIPVLQNLLENPVRGAVFAVILAPTRELAFQIHQVVEGLGQAMGATSVCVVGGVSQTQQAIALGRNPHIIVATPGRLLDHLTNTKGFHLRKLKYLVLDEADRMLSLDFEQELNELLQVIPEERRTLLFSATMTSKVQKLQRACLKDPIKVEVSTKFQTPKHLLQNYLFIPAKYKDCYLTYLINEFAGQSILVFGATCNNVQRLALMLRNLGFPAICLHGQMSQPKRLGALNKFTSGSRSILICTDVASRGLDIPNVDVVVNFDLPGHGKDYIHRVGRTARAGKSGKAIAMVTQYDVEVYQRLEGLLGKKLPEYKLDEETVLVLLERVNEAQRLATRELKEQLAATKGQGQRKRRTGKGDDGGLEESIHKQIRKGYAGGSGGRGGALHNQRGSGQRKKRRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWF9</accession>
    <name>A0AAD2PWF9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002060">
        <property type="protein sequence ID" value="CAJ1960504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="697" mass="78969" checksum="1DBEA2E80AE0FB5B" modified="2024-05-29" version="1">MCIGIRATGGAINPKKSFWWLIDFDWDSRTGKWKFCGKKAVAPDFELPIQGLSGATESLRRLEPDDLERTLGVMLAPLENLKAHEVQMIAKAKDWEEQLRPNLLHKHDVLPLIRSTIMKKLEYPMALTTLDAQQWTDIMSPVFQVCLPKAGVCRNFPWDVMANRTKTGDYMEANFQAHQLETGTSFGLLQQVYTNTAILASDTWMKRVWHELEGLDIYVACDSPALSHRCTDDSLLMDLFINLEVEQEELLWLNWCRMFLQVCTVSDIVTADGRFIRRSAWNGPRDECCHLPYQWPRTVCPTRQHWDLWQTTLSRALLASNGPHHPLQQPLGPWTDPLEDWNWLLSPTTGFFHRHGATWKHFSPEGSSTTSRRQAPAPSHPSCAWWTAPLPSDVLRATVRPITGSDSVLLRGTGRASEPPPPNSPSILQAWQTAAELCRTITGGFQIQGAEATLADALLEGRLRVISDGSFKNELGTAAVQLLVKHGGCHRIIIRCQTPGLPQDQSPYCSELVGLLAGRMAVDWLLKQWFPNLSTCPKVRIACNGLSAIEIAFEDRPLSPTDAQFDLVSSIWEAILRSSVDWSSQHVYGHLDKSNLFDKLSWWEKRNLEVDGMAVEYRKELEMANHLIAPNPRFFNELEARGGHQTVYGSHFLPRDAIFQISIESFDFHEVVDVSFLESCFFPTAQLLLRLCKTSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX31</accession>
    <name>A0AAD2PX31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS20678</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042041926" description="Bestrophin homolog" evidence="9">
        <location>
            <begin position="21"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1964536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54923" checksum="ACFA87EE561B5A9A" modified="2024-05-29" version="1">MKFLNLNSILAVMLIGSTEAFAPANKKTAVLSKTTGSGSTSTSLNLESLEQKTPDYDATAKLLDSYGEQSRKYRRNVFGSADWIKSRRSTRFFDTILSTPKSALIRQISTEVLFISTIALFVVLYNDFLVEGFQDFAGVKHEAFTHALPAFKLPMVPFTLSSGALGLLLTFRTNVSYSRWNEARTAWGKVINDSRSIARMGCIWSKSYKGIDDASLQRLGDAICSFSRSLMNRTLPPQEDEYNFTKYTYERITDQKYAEILRNAKHRPTAALAELTSALVDFKLNPLHQVEVEKVVTGLCDALGASERIFTSPVPTFYTRHTARFLAFWLLALPFGLYEPLGGSWNHITVLPVVAVISGFLLGIEELATQMEEPFSILPMEKMCEGSIRVSVMEQVDRSQKGIQAPYYGEGKMLNVANPYAGEALDAAVVRELPPSMSQSMEEPAPVTHVNGAPNGLGAGGMADTRDPEAFADEDPRKSISSAPTFEEYMKLRNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCB4</accession>
    <name>A0AAD2CCB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1893164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="111"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="215"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1893164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="314" mass="33337" checksum="6671C12033027FC0" modified="2024-05-29" version="1">MATDTKSENAFAKAFQPFACGGAAATFASIVIHPMDLAKVRMQLYGQLNPGKPSPGFTTILGNMIKSDGVGSIYTGVDAAIGRQLVYGTARIGLHRKFSDRLVEINDGNPISFVQKALSGMASGSIAVCIGTPFDIALVRLQADGMAKPEDRRNYKNVFDALIRTSSEEGVGALYKGLAPNILRGMSMNVGMMACYDQAKEVVAKLLNDPMTNGPSLPTRIGASATAGFTAALFSLPFDLIKSRLMAQKPDPLTGELPYKGIADCAVKILRGEGPLGFFSGFSAYYGRCAPHAMIILLSIESITNAYKTAFGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDX3</accession>
    <name>A0AAD2CDX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="262"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="434" mass="48501" checksum="25BA57845875615D" modified="2024-05-29" version="1">MSNEAKNGGDSKSNTAVQLGFSVPFDDDEHRSLISHKSPQWQEWDGGQIGGRPSWLQPKDIPRSGMTCEGCSEPLVFVCQLYAPADEVTPEAFHRSLYLFACASKECAKTCEGTVKVLRTQLPEENPYYPSQPEEEVNWTKHAPTAWDVNLCAVCGQRGKGFCSLQQKHFCSKQHQIECKKCNPQSTDNNKAFFPSVYTESELVVEEEPSTNESKKSLESKGIFTNDGNDEDADLEQEDLNAITGAITSEASKDPTTNEFYARTKVVPNIQDQCLRYMRWPSEESATLASMPLWIRSDHQPPKDIPPCSYCGEDRKFECQIMPQMIHYLMKDHAKQSLEKGHEKNEQAKEAIAQASSILEQAPAEQVPPELAESNEKAVEAMRSKLMDDNDGLNWGVISVYTCTASCGGGLTVEEGQELGAYREEYAWKQPSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFA7</accession>
    <name>A0AAD2CFA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="112"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="204" mass="22430" checksum="646BA4E61096BEED" modified="2024-05-29" version="1">MTVNTLHEQLALQEMSHASPLTHTSSLNAQLRLAQFIELEAAILARRALVPSSWLLRQALADRATGSSGDIGMVLKSARHFTPSFSTTTAQKPSTIKPGGAGLSLDVPSELDILCGRGGKSNHHAGNKRYRQVISDMKARYRSIGSKTAKTHVSRAIVEHVHGYGGRFLRFDTEKRKYIVLSAAEARKKTSQALREAKEVKWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG73</accession>
    <name>A0AAD2CG73_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000164">
        <property type="protein sequence ID" value="CAJ1931606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG73"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="76163" checksum="A0C544675FE96136" modified="2024-05-29" version="1" fragment="single">MDVIKNPGMNLYQGRDQPNKGKGKGKGKPKDGKKKAACYVCDKEDHMSPKYPDRLLPEIQWKHPKHYVDYGKKLNLNQIGATVSTTVTVPGPSPATSVITGGTLSVAGSVNTPLRLAGTTGNQMIQVPTGNQMMQVPSGMQLMQIPTQGGGTVTVPYSMNANGEIAFSGMQLSQQGFCGAQVRQGFDATQARTPQVVKTGYFDTSNVFQDAIKGKDENGNDVYLIPCPAGTTNVELQSDWHYASKNEDLPDLATEADRAEKELDMHTNVGSRVLDEEGFLGRFPPPAYYDEDRIANVLAMREMNANGEITFSGMKLSQQGFCGAQVRQGFDATQARTPQVVKTGYFDTSNVFQDAIKGKDENGNDVYLIPCPAGTTNVELQSDWHYASENEDLPDLATEADREAINHAEAIFGPDASTLKGKSTRPTPKKTYDNFFSPPEELYQHNRTITVCIDHMEIENAKFLTCIDTTVRYRSCIPVPNLKSDPVFEALDKMFRRYNKAGFQVKTIKCDQAFIPLTDDMLDDMGVTINPTAAGDHKPTARQSNRTLKERVRQLIDNVNINYKSDMVAELGQYVHAIGTDSSNSMEPQSIEAIYIEPTKGQRNGHRVLISRPKVVVLPVTDQVIQRVEAWAAAKGVTSMKFFDKTRDLETFQDGDQIAGVDDTEQGYLEEAFDQDYEPEEEDERDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGB2</accession>
    <name>A0AAD2CGB2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1901985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGB2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1901985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="170" mass="18285" checksum="8F903139EA51A5A2" modified="2024-05-29" version="1">MSILEQIQANSISQLKISQDADEISSNTGDIIDALRNNTSIESIHFEGEFLGEMRNTSRVAVVEAIGYIPTLRRVHLADALVLVNAVTKMLCNATELRELSIGNLVLQGIESDFSALEGALAAHNCLKLFKMDKCIPAVKDISLEGLTTSSAQLSSISDPVPNQRSATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGH0</accession>
    <name>A0AAD2CGH0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS2643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000196">
        <property type="protein sequence ID" value="CAJ1931999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="9">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1931999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="540" mass="59120" checksum="F3FC341EA8659E20" modified="2024-05-29" version="1">MKEQPKCVEIEFQVNAMKVVELRKELKRRDLETNGLKKQLQARLRGAMATENTTQRAGSVPHHPDCTSSKQPIGAEKSEASVIQQGNVKGSKESKQLSDGNDNFIEMREVNDQQKTESLKPSVNSSQSSHEAKVSYDEVQAMVDNEGVEEEKWSDLSTNATSPKKTLEEEVASNIKQYWKKLSKPANASTVTSPIIVAMMTHSESKKKKSPIRMVVKTVQKVLPAANDDPAQDIVISASNSDLTDDDFDGPISEFSKASAPLVPVQISKAGSVRDLVSKIQKSTSSASNTTGGDEGSGSALSKNLQAKKEARLARMAEIRGKSKPVMTSKHVLAPKEYASTLSSLNAVSAPVGLKKNNLAAQMREKAATAAIRKENMLSGVNEAFTSTAESAKRDLQSSADSSDNQENLVVSMSMQGFLKKQKVASPMSTYEISDREESDSDTSDSEAENEKQKKKIPVWAQKANLLPALEEQYNGCIGDRRVDPDEIFPEVQTCDLEAIFGGKKSRYTRRTSSGNWTQDKVTTAEKLVYKRTMGFTLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGM6</accession>
    <name>A0AAD2CGM6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000091">
        <property type="protein sequence ID" value="CAJ1929772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="481" mass="53927" checksum="595E3B23A8D43FCF" modified="2024-05-29" version="1">MLVADRFRHILEQGARVTPTFTRSEQSQFLRNLPSRTALAVESPYGKDSNDRCFKTKSTFCHTFVFLYKSGYLDTTTGDRLGKAFSGALLLRLLLKSHEFVDFWPLRSVLPSDTPMGQVMHCWSRMFTACLLHYNLDVATAVRYVGNIHTGAHRDWNALEPELRAASVDDGLVANLRRVLVDGCPNYVNTTSSEKNRRSFAEYGNHDSVYTNIETTQKAVQKDFARSHSLVGNPLLTPFLPDTQQIPQGLVVVPGKSDRQICDGTFRPLLESIATNDMTTKDTEHKVKFPKSLLNHLAYIYNARISYKSEELYLGDDDVSGAFRHGKWNPNVIGMHTFSIFGFLFFCTGLTFGGNTCPSNFEIIALSRMALARFLWSQASTISWVLQYLPAISTSPEPTPDEIAQFTPAEADSINKGVFNPDGSRIPPNFDHHMDDCLYVDVAKTLRQTIASSVLALYLILGFPDASKGIQDCVSWEKFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHK6</accession>
    <name>A0AAD2CHK6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS3830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="103"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="376"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1934490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="89424" checksum="CDBD9374CC6E7E45" modified="2024-05-29" version="1">MAKLAAPARDAADIVDAMDNLVVVDDDEKKDDAEADFDEFGAAKALQGETVLEAQVAAVDEVIALADSAGAVQLAEKAATIAEEVIPTLEKENRNKFVSPKDFELLKVIGMGAFGKVLQVRNKTSGQILAMKVISKRLIRRKAGYIENIQAERNILTRVNHPFVVKMHCSFQTKEKLFLIMDFLAGGELFLRLGREGIFLEKDAAFYLAEIILSLDHLHALGILHRDLKPENILLCNDGHICLTDFGLAKDFGPNWTDQDGGNDRASTICGTQEYMAPEMVARKGYGKAADYWSLGCIAYEMLNGLPPFSSKQGSKELFRKIMQEKVKMPPGSTAAACKLLKGLLNRNPDARLGCARSTMFEVGGVAGLKQAPFFSKIDWGKLEKKEMEPPYKLTVDNDLDLQHFHEEFTNMPLPRSVKLMSLSDDLPARIKSSHFRGFSFIQDEFVLPERDSATMDNYWNKEEEEGESDSEIASSKCDLEDMPEAEPEKKKRPPRKRKKKKKNAETTSVDSAPSETGDAAATTTIAADKKINNSTNHIQTPPPFATPAAAPMEARPTVAVTPAVINSTPPPQKPTPQPKPVWQSVAQPSGTKKNAQTAPTQQAARKVVGMNPTANAYKPTPTKGTTSSWNTTTPQARAISQTSSWGKPGTTPSPASTFTTQQRPVATPQQRTTTPQSRPAPGSWAARLGNTPSSVTAEPSYTPPPPHYPPPSYSSPAKSSSKTMPPPSPSSDWRSQASPLIQRAIKRSSNPTTAQPSPQQQQQQQQQQQQRSNNLFPNAKPSSGGPPPSAPSWPTLGGGKGPAAAAAPVAAPKKQLIGAWAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIH8</accession>
    <name>A0AAD2CIH8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIH8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="19053" checksum="867D550B21D2632D" modified="2024-05-29" version="1">MIDVQSVAELSNHGLEHGLATIETKVEVLNAKMQDLDAAHGILILGQQEIQEVKKSLEVSMASLCENVLPGILAMKEEYYEDPRKTLGQRVQYLENQANSHSVGTNLLSSLSNTGSVDRRGLAIGGSANQLDTVVARLEQLDMANASLREEVARLTADAASQPELSPAPLSAICFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIT0</accession>
    <name>A0AAD2CIT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS3779</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000:SF642">
        <property type="entry name" value="INACTIVE LEUCINE-RICH REPEAT RECEPTOR KINASE XIAO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1934439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="66203" checksum="2DB44F4D742068D5" modified="2024-05-29" version="1">MNHPPPHRKQAGPQADPGDEPPLVSPPVPSREIDPHGEELSLLNSHYDDEAHVQSLMQMTAPHGERLVPGSISPPRGGYGLEEAEPANENPIVAQLAHDDVDDIAARVTERLERRMTERLKHEVEARMALERAANNQNQLEQAPVTRQVASSDGTPPQPQPNIQTAEEAPELEDDDNFKVCGIRRTCWGLLLITLFLFMVATLLSMYFYYGDNNRPKSPDFKLRPPTVSPTIGPSSEDEWTRILDRIGDTIAMDMDVAVFDDESTTQYKALDWLVFDDAYQAGESWRLSDQELVERYAVAVIYFEGLGRTWNRQSNFLEAVPVCEWNNGLSSKDENSEGVYCSDGTVTFLQLVENGLKGQLPKEINLLTNLNHLNLDGNMLYGNLPSLSQLDLLQVLWMSSNELTGPLPKELPPSLANLDLQDNSFLGAIPVEWQSMTDLFFLGLRLNDLTSLPGEFLLPLSNLRYLDLEGNEIQGTIPTEIGSNTKLESLYLEKNRIQGTIPTELASLTTLSELLLYGNGRLGGTVPQEFSQLTNLKFFWIHGTDISGSIDDIFCVDDFVQSLSADCAGDPVEVSCTCCSQCCNSFGAECRQNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIZ8</accession>
    <name>A0AAD2CIZ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000537">
        <property type="protein sequence ID" value="CAJ1936036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000537">
        <property type="protein sequence ID" value="CAJ1936038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIZ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="103" mass="11531" checksum="6B4B5035ABAE4CDC" modified="2024-05-29" version="1">MVQYDGCSNQEIHTGYRSKRMNAPMYKYATMALDWLLGRQIYLLELELILVPADVLLDSHGAYASMIAPLHKNKVGATMCQSMVLANRDNTNICLVMLPTGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJR9</accession>
    <name>A0AAD2CJR9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000424">
        <property type="protein sequence ID" value="CAJ1934964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="123" mass="14041" checksum="D17AA6C167C669DE" modified="2024-05-29" version="1">MSSNNFDIVNSPIMQFFNGLKLKSGEESIELQYLQKISEHPERQNEIFEEMMAEVMKNPSKSYFESTLSNANDLKMMKEMFTSFPLSSSEQEGNQVLPRPKAPDLKTKVSHATELCNQVQAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK24</accession>
    <name>A0AAD2CK24_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000213">
        <property type="protein sequence ID" value="CAJ1932169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1932169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="117" mass="13240" checksum="3976DD6A9AE9DBD9" modified="2024-05-29" version="1">MRLREQAEKDEEKRIKQIVGIANSVGQVRPNRSYVPGQSAPPRLGGRAFAGFHQQGFQGFQDNRSFQTPEIKTAGTFHTVLTTPPTQKQNVRVTDRQGRQLLGFDTSCHKRVTNNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKI5</accession>
    <name>A0AAD2CKI5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4">4.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">AIR carboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS289</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1899888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="119"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1899888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="594" mass="62893" checksum="C1B3107357472488" modified="2024-05-29" version="1">MATFREISDTSPIRVACVGGGQLGRMMALEAPRLGIQMKFLDPGGVKCPAAQIVPSSSIIEGGLKDGDKIRELSKSVDVVTVEIEHVDVETLEALEKEGVNVQPSGQVLRTIQDKLVQKTHFQSHGIELPPFADTPSKDAIKQAAVTLGLPLMLKSRKGGYDGRGNAVLKTSEDADIEAALASLGCKDTSAPDLGVYAEGWIDFDCEVAVMVVRSANGSETSSYPAVNAIQQNSICRVVLAPARNVSLERREICERLAKKAIESLGAKASGVFGVELFVTNDGKVMLNEVAPRPHNTGHYTQDACVISQFENHLRGVCGMKLGSTKMVVEAAAMVNVLGAPSGTSEDTLKSSNAALAMPTAVVHWYGKQGCRAGRKMGHINLTGSSQAELDGCLSELFALEGIPVSLMPGGRLASSPLVGVIMGSQSDLPTMNAAIDMLKKFKVPYEVDIVSAHRTPDKLMSYSRGAADRGIRVIIAGAGGAAHLPGMVAAMTPLPVVGVPVKTSTLSGVDSLYSIVQMPRGVPVATVAIGNAMNAGLLAIRILSTHKAELRQEMKDYQDEMSEMVEGMSSKLLDLGSDEFLNQMDNKNKSVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLM2</accession>
    <name>A0AAD2CLM2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cellulase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLM2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042259219" description="Cellulase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="52512" checksum="1304A73C6C937C7E" modified="2024-05-29" version="1">MNKNTTAAMIRTFTFFSLVVAVASEAWTQDQINYYYQKYNAPLNTCAMQAQCLKYTITENETPSKCGSPCEYRVCWHQGYMGEGWNHGWGNWGFLSACMRYEHVDHIGDMHTTSSLTQKGRSSNIIDNFDECINGINPHGKGYWDSSCTEPETAFSDSYMFANVCQNVPAGHTVHFLMNDGGSCSGTAEQTEMTGHGTKAFCAPSTQDLAEMNPGGQTFFPAYIGASSTGGTCSGMAEGSECVWSVTVPSTCVYEEGDACAGNTSPTYNDDTVCPNQADSVLVYYENDRNAGPPKSPIHDINLNFDGTVSFRVVNPFGDDLSNLYAVYPKAGGHGDSVCPKQSSATDCVSDEVYTAQCMDDDNSWTFVTIFVTGEDGDSQAAQVVNATEGSHGTEVYKCCPKDYEPNGRFGPEHTAAFSYLIHCNCDDEDETEGQARALRVSNDLASQFRGHGALNRKDLKAKFLRGELFGDELKTLYGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM08</accession>
    <name>A0AAD2CM08_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1926693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="417" mass="46983" checksum="B13784C14462E1B1" modified="2024-05-29" version="1">MMFLDPSNAMSHGLMFVARQREREVATKGVTSTRLPPPTNGMEKRKANHSAKDTAAIQTLIEEAMKLQEELIHGLSLRIHHTAQLADRMQGEGGDAEQHLVCVSMRKLKVVQQEYIQALFCKRALETLSEHHEYGLVTLKGVEKEIRAITMCNESNKKSTKTTASKWSDDELLLQLKKRKFFPILRIEDGSVAFGWTDIPPFCNHNVARQRAMEVATKGFTKIHIPMGYEKIENPCTDAVLLISQAEQHVVEFNKQLHKLNLQIHLLVKAATGSLEHGNSVEACLRMKEMESIQAEYLAILKVLEGIKVLVSDIQHGVIDLNLGSQTLEDICDLSNSNVEAEEDLGDEEYLSRLEEKQFYPRLFSLVGGEGVRIFYRATAPDKKGASAPKSIEEAPNKTRVSFQMHQPRREMVSRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMG0</accession>
    <name>A0AAD2CMG0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000051">
        <property type="protein sequence ID" value="CAJ1928537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="93" mass="10142" checksum="B451C89C5D7BB4C6" modified="2024-05-29" version="1">MTSGATVGVEIRKVAATTSLGLETLGIIGGGCEVMRYAWPKMKVTFSIQENGETVPTDLRDPTVVLYGPHRQWEGLLDTHPVDLLVTEKGHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMQ3</accession>
    <name>A0AAD2CMQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000423">
        <property type="protein sequence ID" value="CAJ1934935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="818" mass="91513" checksum="C115F6A2067DD709" modified="2024-05-29" version="1" fragment="single">MSTAGNSTTNRNPSRVLQPGHLETSLVYILETVFGYSAGSILHLALDLYGCKCYLDLVGMDDADIDGLQYPVSQPHDANGDPQPDVLRDVPKPLKAYLHGIRGYVYHRETVLKDPVTLSNCILIDPDDFDTYRASSAFIAFRSRTIPQPLVSKPSRRSPAEEFDLGINLDANLYPTLSNNRQWDSLHGKRLTSEEEHPQYPSLAEPFVPDLESVDLGPEGKYGTLDKENSQYHCLVEPFVTDLASVDLEPDPVVDLKTKREHGTLDLSSVDLEPDPTVDPETKSRHGTLDNDHVQYPCLVEPVATDLASIDLEPDPLAYQACLASLATLPCKKSLCTAKLEAAGSNNQPPAQPPPSPQHPVNLHEMSTTTDFLSQFQHSSMGRSEDADTLTSVTSEETNSDKLALVPATKYRKASQEVKNYEISIDGVDVDEWAKSVPDDGSAGERSPFDRVDILTKRNTTVTTLKDSPALDDAIGFFETHHCVMPTNGLYKLHPGQASDLDWLECNMAGLFDLDPAHVPQLRPPDFEAYKSGRQPSVLFVPETPINFVIKSTPLRDKPINLTYKLSPSAPRRSPRCKTHSEDGRWNSKDKSAEPGPPSHDPNAHDPVLTMEPMYKNLSSAMKSHERNWERLRTYFEWLPKLDIQKLFLWTIVYLARSPVESHHEHKYHLLASSLESICYMLGTVGNVEHPGCHMTYKFLFLERNNFLFPSEICSARSPTKLHKRLDLPDGEELMLPTIITSIDLSDGEELAPPTKIKSSDNQTIKTVVYSSEDELDIEDVLLGNWDLIGQTFLLSPDESYVRRAKIVELNYKHNRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CND8</accession>
    <name>A0AAD2CND8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CND8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="218" mass="25659" checksum="08FFB7FC7C564266" modified="2024-05-29" version="1">MVNETVNSIREMIGGLAYNTPILISVDGKKEYNNEDIERLQKYVENLRIRFLRDPYVTILNNYQFGHISNSIRVALQVVETEFIYVVQHDFKFIKPINHTSLVGVMREHPNQIKIVRFGKRKHREDVLDVCDEYNELDSVKHGLYLALAHWSDNNHFTTKKYYAKVLDNIGPTPRPVEHPMMNNLILNASDCTYVRQYLYNWKHGPFIEHLDGRLTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPQ9</accession>
    <name>A0AAD2CPQ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPQ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649:SF13">
        <property type="entry name" value="ENGB-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649">
        <property type="entry name" value="MSS1/TRME-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="6">
        <location>
            <begin position="251"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1942228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="539" mass="59983" checksum="9E01F52E651E52C6" modified="2024-05-29" version="1">MVNQSSFKILQQYSRSPTTLLRSTSSYSPCMTSYRFQRALSNDILSTTKPYGHYSSVLSFSSSTESDHLFSSNRSNFKEIPVNPSILSYIENIGIGIPKRIPVKRRLNRLRKKNSANRNYSRRNSKSEFLTREEEAESLSPSIRRLPSRIPPPPFAMPPQSKPRRNDAMIETESKSHRKKPIDGKKNTRGNDKNKKRNHSNNKSAKQTSNEQQPLQQPQQQPQQRSIRRYPVKCIASVGTAEESFPTGSLKVPEVAIAGRSNVGKSTLLNALLYGNHPKASQEQDGNGDESIPSHRNQRRGKGPKPTARTAKLPKGLKAATSSKPGQTRTIDFYRLTAKTSTTSTITPKNDEAAGDNTSEDESSSVEETLHTTTKISLQLVDLPGYGFAYATDDKMEAWKSLMQDYILNRGKPLKRILLLIDARHGMKIADVEFMESLQEALKKQAASSKNHPSAKKKRELPPIQIVLTKCDLVSQADLARRVTQVRQQLSDSLIRQPSALPVMLVSAQMEGQRGVLELQKELASLVPGIIGAKDAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ08</accession>
    <name>A0AAD2CQ08_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="230" mass="27363" checksum="3546685A8826EA9A" modified="2024-05-29" version="1">MIPNLLYNGCGLCYHQEYDEQIRDDVIDMKKEDRAIQEWRSRNNNNNHRPSSLSSVSSRRYRSKRTRFADNNEEEDGEEYSSSQQQQQYSAQTTASPSSCRVRSTRKHGRGRCWDASTVSASTRQIQAEKNLLHRNLRAAQKELLAQDKMIVQLESDLQVFEMEHSKLEDKMYLMQLDLEDAQTALRREVLRNQENERLLQEYKRAEAMKQEQEQEQRQDEDNSWFGLWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR94</accession>
    <name>A0AAD2CR94_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001125">
        <property type="protein sequence ID" value="CAJ1943751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="232" mass="25875" checksum="91520062B0521212" modified="2024-05-29" version="1">MRRYISKGVVVSLTSFFAVQKGDNDIRMVYDGTKSGLNDAMWVPRFGLPTIETHLGSIEEGTFMADVDVEECFLNFPLHQSLQKLAGVDFTKYFPDPSQSTVWECWHRALMGVKSSPYQAVQGMTVSDEVICGQPEDSHNVFRWSRVRLNCPGDKDYDPSKPWVSKIRSDGKIAADLSGYVDDLHPSGSSQVEAWHTSRQAASTLNHLGIQDAACKLLEISDPLPPAIYLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRS0</accession>
    <name>A0AAD2CRS0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS8328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="242"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="340"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="443"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1943204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="545" mass="59686" checksum="9927C77A509883BE" modified="2024-05-29" version="1">MSVQAVVDTREHSLEDIELGSGRWKAKKLSWEHDAGRHVVSPSFATYAARILLNFDPSVASWWRGLQLTYALLPLEEQRSMLSQRFGSFAASIQASMDSFIVEEMQVNNDTKTAWEKLFSRYIEKYGDSDAALRQICILFSILPMSEQPLEHIQQYKSSIKPDTNIDQAINLDSFFNDYSALLPGYYGCQISANASSYAIFPLIDLYEIGINEEFGQAVTATTFGPLSSIALSRDLLDYSLDIYALFGVSGATGCALTHSVVIPLDVLKTKAQTNPEEYSDIISGVSRVVQEEGLQGLLTGAQATLAGYFWYGLSVYPSYAFFKRFIGQSLLPLDFSALHTNDIALISGALSAVIASLGLTPLEAARIRVVADPNRYKPLGLLGTMKTIVSEDESLGWKALYAGLPALMTRQVIFGSIKFLAFERACDAIFMNWPSLRDLTWTALGVSLVAGAFSGTVSSVVSQPADAVLTYVAQRTDTKGNLSVIEGCRLMIEESGVTALFRGLGSRSLWAAAIIAGQFLLYDVFRNAFGVTADDLTQVYTLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS73</accession>
    <name>A0AAD2CS73_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="1269"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1754" mass="196443" checksum="F0B8219C907899FF" modified="2024-05-29" version="1">MPTESDGQGESPPDPAHSGSDQIRPRNRNRRGKQKNNTKFGAASQSKPPSTVEPELKGYYYELPNVDPRVPPFLQVVKAHIAYFVSNRKDASDYLMVGESTSTAKDPFSLPPLVAPNLPDWDNKQEEHDYLKKDKKYEAEKSVRKANEAALCAMLKRHCSAAFLSAAESHPKWGTVIANNSSMDMLKVFQIVAATGGSTNVDPTMMGVEAQRKAYTCKQKENQTNAEYLQVFMQLSNTARFCDCPMGASLSRLIQETGKSDPTLAELRAVEEKVVEKEMAMAFLLGADRKRYGGLIAQANNARLFSGSDTFPTTMSGAIELLNNSKPLVASYHSSIRSSEIGASFLADGQPSTESGTGGRGGGPNGRSGGGRNGGRGSSGRGGRGRDFERRPNRNHEQHETHITDTSNNNNNDEVDEYLTTEEPSDSTNPVNTDSIAVDEDVSTTEHLFLHSNNKSYVKLIPKRHPQSGLPVTWIVLDTGSTANIFCNRSLLQNIHKVQHGLKVRCNAGVVQLNMKGYFGDYPDPVWFNPDGIANILSFHDVNKHYHVVYDNRGADRFVVDFGGTKKVEFLPTDKGLYHIDLDDYCKTSWTFLETVKEQKAKHTKAAVMRAAQARHIQNIIGRPGDRRFTDIVNKNLLRDCPVTAEDIRVAHNIYGPNLGSLKGKTTSRNDSHVRTEVGPIPDHIQQLYSEVTLAIDILFVNKVPFLVSISRHLKFGTVERLTNRRIKTITDSMRKVFELYSRRNFKVTCILGDPEFEPLKQQFPNIQVDCCGADEHVPEVERFIRTIKDRVRSTYNMLPFRRIPKLILEHMIRNAVFWLNAFPALDGVSDTLSPKYIVTGRNVNMKLHVRTEFGAYVQTHEEHSNDMRARTLGAICLGPTGAAQGSHYFMSVATGKRITRQHWTPLPMPTDVIEAVSNRGLQQGMPTTLTFADRHGRELIDDDDEVDDDHDSLYSSSDASATHTHTDDDDISYDSDASDVTLPPPQTPVDDDASAYDDNNSVDDADENDTTHSNDSDTDDPDNDQPPDNAGILPAGVNEHQLQQHQPQFPDENTGVNARNTGVDARNTGVGRGNTGVDARNTGVGSISTQMDPQDGGSTTSDDSDYSSEDDDAREQAAADTQLDELIEEIQQEVQQEVQELQNLTQNQNQQQINDDMDRAYGERGHGRNLRPRKYPTTHGDHQVLIQVPHRDEPVPEYTEMVTLFHHEVAFLTEQMSAKKGLKVFGESGAEAIVAEMHQIHYRNVLSPKYRSQLTPEQRRNALRYLMFLKEKRCGKVKARGCADGRRQRLYKTKEETSAPTVRTESFMITCAIDAKEGRKVMTIDIPGAFMQADTDEIIHVKFEGEIAELLTKVDPALYTKYVAYEGKKPVIYAQLNKNLYGTLQGALCWWKNLSGFLVDELGYEANPYDSCVVNKMINGKQCTIIWHVDDLKVSHMEQEVLEDIASRLSERYGKEAPLTIQRGDVHEYLGVTIDFSEKGKVKFSMDDYVDRLLEETPEDMKGLATSPAANHLFQVKNEPVLLDSKRAELFHHITAKLLYLCKRVRGDLMTAVAFLTTRVSKPDEDDYAKLGRSIKYLRATKYMPLTIELDDKFVMQWWVDASFAVHKDMKSHTGAVLTMGKGAIIAISTKQKINTDSSTVAELVGVHDALPMIMWSRYFIISQGYEVVDNIIHQDNQSAMLLEKNGRSSCGRKTRALDVRYFSITDKIKSGFMRVLHCPTAKMLGDFFTKPTQGTLFRTFRNLIMNPSDQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSD8</accession>
    <name>A0AAD2CSD8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001180">
        <property type="protein sequence ID" value="CAJ1944019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="294" mass="32684" checksum="AFE9594A65D72DA6" modified="2024-05-29" version="1">MEETNFFNRYWDFTSEVEPRLLLELSPLAIVWAIAVELLGHPWTEPDTTTVVTELAERRSAAKGQKRECDLDPSTEQKPAPIDPRSPAQGFFPDATPKPVRDSVAPNKDDSVMMDTTGPSVISPTNKPVNGKFAYWSDNDGSESVESAPDFFAPSNLDQPPTEVIVGKSPAPAQRANNPSATVLIDSHWSKTEPPNPPRPSAPLSMKKQLTYVAASKKKAAIRTKYLSEEMKAREVTQVNLTGLPRSNAQFLCATINYEWDGNTSEGGSIEVKKWSRSCPWLWTTLRATWSFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CST8</accession>
    <name>A0AAD2CST8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001082">
        <property type="protein sequence ID" value="CAJ1941817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CST8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="494" mass="55417" checksum="9DC880ADA7B2E731" modified="2024-05-29" version="1" fragment="single">MGKSINAKASSAMTKKSGVSKMKTTSVAKKSVKKRVEIDLQQPKDRDPIGSKMVSETQTEEKRVTDDNEAQRMADEIEAKRIAEREALRSGHYDSIVPNLSEWWMKNLYSGDAVDEALERHDRIHTGNALFIAWEERFPGVWNQPCLRQLTKYLIAAFDTETMEVNPSEEIWSLRILAIRISLQNPFSFFGIDEFEGKPDDNHFFSGKLANPRLRLEHPLVGFWLIKQTRSGKSINKARNQESVKEPDPPRIQKTYDPMYSIDEPGTDVQRDSTSPKGDQVQNSNRFAPLQSDDDSFDGSGIQEFDEVEVVAVKKNYSKAPESSDEDEDTDADDTDDRENIVDDAMEEDNDDERVNTAGANPHHEAMDHNTPPLTSPKLTATQDSAGTGTLIEPSETTPSRVQRPPTLAERISNLIQVNMEGVPGKCHIFETTFSVDYQGSDSGTVAGALLLTVLNSMEEAINNSPNELKLLPISDTTYKQPNLWIRNSVDLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTS7</accession>
    <name>A0AAD2CTS7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTS7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1943625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61337" checksum="EDA0A5371488B874" modified="2024-05-29" version="1">MLQETSEEERLLRLADLFDKQLCEHDWALRVLKRLILIRIQLYGSHHYMIADSYHRLGDVLQKKGNLEEAMEAYEKARSMFTGIILTEGHSDFSGLIATVNSVIRSQTKLQEALQAQCASLEYHRDIFQDEGNSSSIKLRFKSRSRMSQTEDMLMKSIDQFQRKLSSVFQPSSGAPLNGVLDHIAADDIMKDPATTVNDAIQCCQSSLADFRKADDHQGLSGADASENASMATHALHELEHVLETFHRALKRTTRILVEMQAKLAIIYNNQATVLQLRGDLDGAMNKFQTSLTIKKKTLGEDDAQVAERFVYLGNILELQGRTELARSRYEKALVILKKTLGEDHSFVADTLVKLANVLSGQGQREKAEEHYFKAIGIYRRTLGEEHLSIANAFLKVGDMSCVQRKYDRALEMYQSALGIQRIALGDDDVTVGDIYALISSLLRKQGKDNEANEAYEKYLEIKKKSLGEETLALIEYELERAKELAGEDKPEEAMSSYQKALDASQEAFGSEDVSIAFIYNGMALVLSQQGTLGRAMMLHYKALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUE7</accession>
    <name>A0AAD2CUE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS9795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1945651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="654" mass="71800" checksum="EFDFDAD95D250900" modified="2024-05-29" version="1">MNALELTENHGSSSRGDDDPPFFADMTLDLAEAHDIAETPEATHRKLLATKDQLIAMPKMPVIPQDRVITSSLSNSDDSISPKFNANLSSITHEQTHGRISAMGNNKPLQATRNMPRDIYWAIAFAIFVPFSLLGPIMSSNDAESKTSKTYWLGTSLAPRMATVHSLWWAAIAAFLLSRLLYRTLGGGDGDDARHLASQIVLSSAPISLSIYSSLILTIYFFLPHARIYIILPAWALARDIYIFRQWKMTSSTPGGRQAFFQALTCMTLDILSRSLRRASFYRIVSALLLLQLMVIGLWRMALNAAMHSQSTFWLLLAAVGGKWATGAVARLLTLISSGGISSWFAEQNALVEEMEQMKGGRETENGLSNSSSLHSKSDDEDSEMPEAYRMTAASAYQTTLTPDEGMDDDFEDEDDAEAALNAPISTFLSTPIAGGSTVKQLLLKGVTVNFGSVCKCGLLGGLAQFVWSQLRKIDTARAKLSGFQTMSIGQSNDFQNSKFRHYLMVSNRLARGFVRNNSDMAMSHVAAFQKSYNRAAQDVAILIDESGVEPIIHDDISTHMAACVGGSISGAIVMFTGIILVHQKKSNTTDSAVVMDMVVSFIFCYTLIFTVMEPLRASIKAVYVSFAQHPQSISQSFPLIFHRLSRMAKSNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUH4</accession>
    <name>A0AAD2CUH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001621">
        <property type="protein sequence ID" value="CAJ1946155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="194" mass="21859" checksum="59DF0DC18720BD33" modified="2024-05-29" version="1">MYCRQLSSVNKQPHFELSSKQNGYAGLGMTAKMATVRKNKEGFTPRQVKAAMEARSAMHILNAPSTKSLKYAIRSGLIKDCPITEEAINHAEAIFGPDASTLKGKSTRPTPKKTYDDFFSPPEELYQHNRTITVCIGHMEMGDAKFLTCIDTTVRYRSCIPMQNLKTDPVFDALDKIFRRYNKAGFHVKTIKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUK9</accession>
    <name>A0AAD2CUK9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS9376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUK9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041966352" description="VWFD domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="204"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="564"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="851"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1143"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="853"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="900"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1148"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1945232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1197" mass="132358" checksum="E1508DA243832374" modified="2024-05-29" version="1">MKLFLLLLTALSVLQTAAAVDGQPFWELQDENGIKIGKGKKCPYDSTRLFKYSTSDSDDKIEDCVEKCKSIQNCKHVSYGFYNNQWMCMGCNGHQYGYDDHEPFTVYEIETPDDWQFTKVAAKRDCGSQQYGSPIPGLTQAECHTKCKDTQGCGYFSVSDLDFSPTGAGTCKLCKWSDGFASKSSSNTYSILSPADYKPVCEGPTGVVWGDPHFITFDKLKYDCQGRGEYVLVKSNGPDPLAIHGVFEDTGGSRTGPSVTRSVAILVDENVPVLHITIPDMPDANGQCSFSYTLGENEIEIAADEIVDYFMQNYPGEANVYTNEKAVVVTFPDYQTRIEILTHSGSFSKFGCRMRANICVTPQNHGGDIVGLFGSPNGDKTDDWMTSTSTPSLLPVPVGSRSKLRSEGTSYCRENWCVPRSSTLYGDDTYTAHNKCADDSFDPRAYEEMIAALPDSIKELCNKVENPEECIADVAVLKNMTEEAGEVVDLEDAVEGFSDEEEDSNKVSNTREAELYAEDDWKAPNVTTLNTLSTQASSINNGLVSEVNITVSDEEGPNPACPVCKARGWGDPHIITFDGVTYDVHVIGELTFLKSLSTDFEIQARTEIVENHPKGPAVTTAVVVHEDSSKNLPVVQISLARPVDGPSVGIGKCPVQLFVDGVYRDITTGTGSTDVTVQVNRKRIVLEYPSTNLRLDLQVKTWRNTCHFSVNYILSDCRCDETLVGILGQPDGAPMNDWHDHSGTPVPIPPKNKDRRTQKAYDYSLTWCLESADDSHFTYQGGNSFSTFDKCNPEQYDDTLDDIIENADPELISNCTIDGEVEYGCVLECDFFGEGACEEYKEVIQNTETAVITSPPTSSPTSGPTSGPTSGPTSGPTSGPTSGPTKESDLSTNGNGNTFEDVEDEETTDTEEVDEPEEETTPTDTADIDEPEEETVPPPDAGSRGDPHFKTWKNEHFEYHSQCDLVLNRNPTFADGLGLDVQIRTKLVRFWSYIRSAAIRIGDDILEVQGTGDEANTLRYWHNFEFQKEIKTIGGFPITLKKGTGRFMKNRFIIDLDSKYPGQKIQITTWKEFVAVEFKNASAEAYGNSVGMLGDFKTGQTLARDGRILHDFHEFGDEWQVRPTDDMLFHDVEKPQFPTKCMMPEDPQGERRRRLDESSVTEEQAEAACASLTDPLDRKDCIYDIMATQDTTMAGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUW8</accession>
    <name>A0AAD2CUW8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001291">
        <property type="protein sequence ID" value="CAJ1944980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF100">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="490" mass="53111" checksum="F2DBB38903385CF9" modified="2024-05-29" version="1">MGENSNELMVKAIKEGNTSRVKELLGAGGDANANDNITGQSVLHQACENGHAEIVKTLLEKGAGVRAKDDDGWTAMHWACSAGHVDVAKVLLEKSAYVRAKDNNGSTPLHKACHNGHLNVVKVLLEKDADLAAIDDDGWTPFQRACFQGHLELVKWLAVEKGADLHAKSNNGSTPLHKACNNGHAEVAKVLLQKGADVRAKDNDGATALHGACTNGHSEVVKVLLEKRADVHAKDDDEETPLHLACENGHLEIVKLLLEQGAEVNAKSDDRWTPLHKACFDDHLDIVRALLENGAYVRAKDNNGQTPLHEACEKGYLELVKMLVERGADVNATNSSGKTPSDVVQPYHAKGPQIREILSKPPPKRRSRPTPPGLDNSYKAVVSKPIFPDAVLSVEDEYKLSLHGAVKYGDVDVIKEVLEEIATEEGDKNAVDSKGRTAVDLAALTGQMEVLKLLAENGVKHVSSKPKMIAICKKRKDLSEKYLEQVNESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV58</accession>
    <name>A0AAD2CV58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS8106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1942756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="249" mass="27412" checksum="E9800B224D5AC202" modified="2024-05-29" version="1">MLRSAASLTLRHSRKAVNTSLLQDLSRNNYLLSSQSHLRVRSSDFLRTLSSQTKKEEPPKKKGGEEDDETKEIVLTPGETVVAVSRLGLWAGIFAFACACAFYIGRELIPTKMSPNSVFNGATSIIRDNAQVKRVYGDKLKFYGKDHGGHREGRRNFIEHTQYPSPDDGSNRTRVRFNLEGEFNSAFCFAEVSSGMSSGEFVYILVQDKRSGRVITVVDNRAALTAKQLSGGNAESSQALQQLLGGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVH5</accession>
    <name>A0AAD2CVH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9039</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9049</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9057</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001247">
        <property type="protein sequence ID" value="CAJ1944757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001247">
        <property type="protein sequence ID" value="CAJ1944777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001247">
        <property type="protein sequence ID" value="CAJ1944793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001247">
        <property type="protein sequence ID" value="CAJ1944801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1944801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="28835" checksum="7F68DEE32650054E" modified="2024-05-29" version="1">MAYRNIHKWSEIDADTPIVWNLKWVVCCHHYIRLEHPSYLGLTFCMAIGWKHGENTPEALSITGADDSVTYTIHARNHNLLESQGCKPLGNIVKDKKKLLCPSNQVKLRLLHTTSPKCMLNGTSIDFLSKEQPTVETATYDSEPVATQTCAKQIMDLQQTLRYLGVSIRGQSYMSGDNESVMNSSSLPEAKLHNQDVALSFHRVREAVAANMLSIIHIDSALNPADILSKHWGDQQIWTLLLTLMFWSGDTAERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVK8</accession>
    <name>A0AAD2CVK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001269">
        <property type="protein sequence ID" value="CAJ1944910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="216" mass="25517" checksum="C7C2863013DF135D" modified="2024-05-29" version="1">MISSIKELNEPDWDGLKPKLDLTGQKDKIEREAKKEELKTESVEYHRQKRYWSKAKWHVHSLIMESFVTSKMKDKILQEVDYNEKIEGDPIELLRRINKFMTTSDVTDWEPITLWEALQKWVNCRQKGNETVIEYRKRFEECATTVLSFMGDSWLEVFAAKTTAYHEIENNHPTNGLSDREKKRVAAEVKELQEEFQDEFVKLFCAAGLLHNCDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWE5</accession>
    <name>A0AAD2CWE5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS9583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001424">
        <property type="protein sequence ID" value="CAJ1945440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWE5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="149"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1945440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="312" mass="35933" checksum="DD1EA340642B6E4E" modified="2024-05-29" version="1">MRFMNVSLFFTSDEVLVRGFRTIKALPNITIDDNNKRNNERFMSFFGVSTTVISFAWAYILKSPDSGIDLKDKSEKGFQKILTACHYLWARPKNNEILATTCGYNCKRHVEGENLWKYVKALAKIKDQVIVWPETKYNNPRGQKILGTIDGVDFKTREKSTDQFNQCPKQFTYKHHHCGVKYELIVDAYTAKIVSINGPFRGGMSDKEIYQNKVKDRIPDGKFLVADRGYTNNKVPGWNDKFAFPSHTDSKWLANTKSRLRCRHEAVNGKLVQFAVLHKEFTHPHDKHVFAFEAVCVLVQLSMNFGHPIWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXB8</accession>
    <name>A0AAD2CXB8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXB8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042229793" description="RWD domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="56120" checksum="55F4E47B4AA9EAB2" modified="2024-05-29" version="1">MSSSTTRSRQTAMPKSWILMVTLLLDTHVSSLQTQRLFYDATRTCRSPTTTMSTSYFTPSVKSPLPPQCGRNRKNLIRHAIIYGDDGEYQTEEEFDASELLAEQDLKQSVSDRIYSEFPPAVLINIACAQAAPPHNHLMPKDCLSAELVAVNTRGAQIAVSTLASAGGEGDGHCVQLLIPIQFSATKSELSPPPSTEASLTLDYIVQQFQHLESDSIKTIAKKEWEDDNADQFAAQEKILFELQNEATLTEELLPDWWTFCELNKGLEEEADNMKELLNEDDFATDLNVLFQTNYHHDSDSPTIQPIKTCVTSIGPSGVYLRSYVERQEEVDDKYFVAKLSVPFPEKTSSRDDLRLSILKMIENAAEQVVARGEEEELLLVETASATIVQGVSSKKAYVFQEQLLRARIQVDQLASKRRHAQKEEALHRSLLATKLSIEQKQAKSPVATEEGVKTTPSPPPSKQQQQQSLSKSTEKELADKYASIEDVGERAYTILKDLNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBU3</accession>
    <name>A0AAD2FBU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1904425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBU3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="105"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1904425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="183" mass="20651" checksum="1DE20D12FD911887" modified="2024-05-29" version="1">MVILTETEALVTPRNPAAKHNFGPISFREDTLFTAERPGHPGTNGVPTEIVEDWIRFIKSQGISNVLIIMDENEFGVYEIDLKDFYQAAGLKVFHIPFSSPDCYERTMALIEEMDRKGEKVVSHCTGGKGRCGRVACAWLCKKWNLSPLQASQEFIDQAEKRGLYRLGDVQKLKSWIGYTSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCL4</accession>
    <name>A0AAD2FCL4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1920857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042065016" evidence="2">
        <location>
            <begin position="23"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1920857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="357" mass="39669" checksum="B8A00399BC07BCFC" modified="2024-05-29" version="1">MTMRNVHALGIAFATLPLFSDGFTCPTFHIQESKVILLATESTGPKASGRRRTSRRTIADADSASGPRASRPRRERPQQPAPFDGKAMTAVQDPNEGATPLNLHDAISDGNIKCMSEGIQFDQAVKTPAFKFMSLDDLFGKDVGLSTKFNAEAKFREDLRIAIRQDIFDSTPFYASLSEKAASVLLLPDSSLEGSWRMPESMNRMNKTTAVLAEALGESALTGDELMKAIGDLCGSRPSTHFIDIYGVQDRAIGHSFHMDFGKSPLNTTQTVLWGWPREDDYNGCGVFSHVIPLEEECWAPENHPRMEPVLFSGSFEENNIVRPRYQPGRELLIYRDVDVVHSAPDVTYRTSVMRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FD51</accession>
    <name>A0AAD2FD51_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS1525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000058">
        <property type="protein sequence ID" value="CAJ1928680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FD51"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1928680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="210" mass="23115" checksum="1D1DC9736234F707" modified="2024-05-29" version="1">MRSFPHAWGFSGGSVDSTDDSLEAAIAREIWEETGLKVSGSSLSAMQALDASAGDGEKTTTSCSGWTIECIWESVFPTIPEPRITIKRHHLVVYLSIKLSEREMSQMSLKLCDEEVDAAVWLSPKKVNSILAKGLCRADSSVSEEEIWVDLLTSSNTQVAAKTGVKESLEHLSGIYPRFDDDDTSSQHPFGMAQGSLFALQEYCNRHHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFD5</accession>
    <name>A0AAD2FFD5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1907227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="12">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1907227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="773" mass="84893" checksum="EF31C535982E8135" modified="2024-05-29" version="1">MSYSVRILSTKSLDSSPSVLLVSSDGTKTLVNCGEGCQRTFLEFGQKVSSMNRICLTHLSHDSIGGIPGMILTAADVLQDAVSSAKAALVHNNKKPQKPEESALPGLHLLGPVGTQKFVSSLRHFMRRDSFQVKVHEGAYSQPKNGGPKKRKKGSKNEGAYDVQSIVCHTNDFHRSEDSTKRQRLETNDQALSYIFTTPPIQGKFLVERAIALGIPKGPLFGQLKNGKSVTFTNEAGTTRTISSSEVVEPGSPGISIAVLYYPSNECLDQLKSSEKLKEYQENEKGHPVLEVIVHMATRDLFLGKEAKEWRESFGSEVKHIFLATDLRSSTETSSPFHSGMMGAIARSKVCSSVYNVPNIPIQLRETTPAAQPEGETVPGYMEAQPLLEYIIVPRSKRGFGSRNASVLHWRSIQKQVLQILEQSGAKGEAENALSHHSSVLTSNANNDKNRGELIFTGTGSAIPCKYRNVSGIYLKMENGNAMLLDVGEGTVGQLMRALSSSFSEVLCAIKAVWISHPHADHHLGLLRLLSDRNQVTDDPLLLIAPTSMLSFLLEYQEVDATVQGSYTFVDCKEVSTKVQRHLWLPEKHESHAKKMEQLHKDLGITRCTSVPVAHCRDAFAVILENTCFGRLVYSGDCRPSRPLAYAALGADLLIHEATFANGMEAEATLKRHSTIGEALQVAEDMKAKAVILTHFSQRYPKVPPVASKHNAPIVFAFDFVRVTPDNLLVAADLTQSMRLLYSEETAEKDEIMKDADVEAMNVPGLFAQKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGX3</accession>
    <name>A0AAD2FGX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS5941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1938034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="8">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1938034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="154" mass="17052" checksum="09F121996EC398BE" modified="2024-05-29" version="1">MVSKNNTEFASPSSVASSSSSSSTNNSHDETPIITISENNIRIVLDKDDKTPVPRFERNSYKLERDPCLNGSRKPTNLAFCPHCSKENVRTRTKTYPSAVTWGCVAIGAVAFFPICWVPLVMDGMKKTDHYCQNCGQKLATIKPLHGVGVKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHF0</accession>
    <name>A0AAD2FHF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS6245</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000757">
        <property type="protein sequence ID" value="CAJ1938711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="1021"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="15">
        <location>
            <begin position="1350"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="16">
        <location>
            <begin position="1479"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="149"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="770"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="902"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="276"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="923"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="943"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1938711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1532" mass="172308" checksum="F547368463BC6F60" modified="2024-05-29" version="1">MPTDEAPTLRRRASSGASASSSNNDASTSVASSRPKRRSRGLPMGSTTPPRRRSSRDNAPPKVETPPEYKKPAAAASQKPAVDTKKTTSSRSSTRSSRRSSARNKTSPKSSPQQPQQPEFKITQEDPGSLLAAVIKKKSVTVQLKLNDEVYNFDSSSPLKQEEEVPQESTTRIKTEPFEDAESSPKEEELSTPSSSKTNGKEGGEDGSSFTTPRASKRQKLNKDSPKEMVEKEDNGSGQEPKDQAEEEQESPRRRSKRSASIASVSESMKSSPDKEDQDDDDNSMDEEDDSGQDNGEEGDDDDDNMEEDDDQEDDQEDGDEDDEDGDEADQEDDDDDDDNDDKEGEEDQVGEEDEESKNSKDLAKRSSPRIIKKTKSVTNRRRASLPTSSRSPSSRIETAKRKKKKKKEKETESEESRAKQKSSRTKKSPKSSPSSSKGSSSSKSNRPNSPVSRSSPSKHHHRQVMNYGANATPAFYFFLAENRSKLERSLSRRHRYFTRLPKGYERNELVAKEAAAWWLKLKDSEMRRFMNLSMRDMEERITEWKEAKNIQNMTAQNDLAAYEDPSELTPEDELMTFERHNRLFLGTTVGCKPYKPESGVSHNRILLELLQDMRFHPAPMFIPNRDEVEYGQMDFSRVSIPYFDVHGPVSTSMGDDCLGCTRGWAHYCNVLKRKVPAVDHRARLQPPLSSVIATRVGLGLQPKPQTALEVEGATPESVKNLEMLTVHENAEAKKARCLPCYHFETLSNPADRSDDIVRFIEETVAMKVSEPTRPTDPSRPEIGKKGASRAALPLSRKRSQDEMHGGGAQESVFNKCGRCRTVIQTDTGCIQCRRAQLVINLSKKDSGDHRMENESGNYLKVSTQMLGRLTMKEGAMDYQSPGDVAIAQGILRQRWTPFAVLPPQPIEFPKPKQKRTRRQPVEVEDSEADSSDPGESMQSDKVSVEDEKSDGTDDKMDDSSHDEMMEGTRTRRNRASSQGGGDSDTQEETIDRQLMAQKMKDEASELNKKCVQTACFGILLGLMRRDPLLLFASPVSAEGYSTIIKNPIDFGKIKANVLAENYNTLGSFVSDAKLLCTNALIYNPPGSIYWKTAKELQDVLGEMQKRASEWIREIKDCHANAWRNGSKVKVGIDESDLYVEDVFEDLRTKWPQAVEMLDDRDRLRQQLESDFMRTKENETAYYGGLAIRRAAIAADASLAPYPDQAGIFNPVGRRSHVEDENLRNMISERVAEAVDPVQLKDIPMWREESIMRLLRRSQSRRLDGLIGSVNGCARCDGMRIDQDLKTAMTAETIRWGRQKKKNSEVSRVVESRMHLSTGNASQKAVEEIKKRQELASESEYNSSHVTTAGAVTVKGSGIHGWGLFADQPFKAGEVVAEYIGEYVSPATTEARERMYQEQRIQDYQFRIDDHLVIDATMKGGHGRYINHSCSPNCIAKIIRGETPNEHLKRVLIIAQRDIDAMEELSYDYQFPLELDLKARIACNCHSEQCRGFMNWDLPEKGSNSRVFRSQKRGANMRDRIRRLGRPLKGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHT4</accession>
    <name>A0AAD2FHT4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BspA family leucine-rich repeat surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001053">
        <property type="protein sequence ID" value="CAJ1941646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHT4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042053159" description="BspA family leucine-rich repeat surface protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="52841" checksum="2FF06D3D6720F649" modified="2024-05-29" version="1" fragment="single">MVRVSSLFVSTIIWCLMLAPSITTSASSSSIFSCSNDDVSAQQQVNANGCACFSEEIELREAVDQFISEGCSDTNNCNNWVVQKYGWPMGSWCVSSVTNMYQLFYGRSFFNDDISSWDVSSVSIMVSMFYQATSFNQDLSSWDVSSVVGTVSMFEGASSFNQDLSSWNVSAVTQMASMFNEASSFNGDLSLWDVSSVTQMYWMFRGASSFNQDLSAWDVSSVTDMASMFYSSSSFNQDLSSWDVSSVINTYSMFNGASSFNQDLSSWDVSSVTDMQFMFYRASSFNGDLSSWDVSSVADMRWMFRDASSFNGDLSSWDVSSVVNTKNMFNGASSFNQDLSSWDVSSVTDMAFMFHLATSFDQDLSPWNVSKVEYSEGIFEGTVALDECIVCQWSDAWKRHFNCIGCASPTNAPHLPSSCSNDDVSAQQQVNTNGCTCFSDDIELREAVYQFISEGCSDTNNCNNWVVQKYGWPMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ37</accession>
    <name>A0AAD2FJ37_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="225"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="422" mass="46504" checksum="4550E810CF67245A" modified="2024-05-29" version="1">MRLSTIATRISFILPTSTVLSWIPQRTSPKINRLQSCRSQRLSVLHSTPPPATSTSASADDSSISMGTLASDFRIAISSSVDTLSWSLYPLNGMPAKDALSTPPLGDAAASWTITCQPTESKSLGVEVSNSDATVSLEKDLITVLQIVLFQSFLKEHPASNEEWHVGIDENHSLKVSDILAGDGVETLFSSLKDNTSSVEWVDMVTGSGKVLGRVPRPLVHKYNLLHRGIGMFVTKDKAMVEDSQYAFPPLYTHQRTATKRIFPSLYDMFVGGVSLAGESSDLTARREVAEELGLSLALECPEALSDPILDCLVCTHLNRCFVTLYSYTMNTEKETVSWQEEEVAWGDFVAYPIIAAAADLSIKRLEKQKSWPGIYPAIQSDLNGVAPKDISYENGDWNQWDFVPDGLLVWEAWLLQLQNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ92</accession>
    <name>A0AAD2FJ92_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ92"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042121326" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="161"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="307"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="451"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="636" mass="66823" checksum="66F41D860A1BF792" modified="2024-05-29" version="1">MKTTITLLALALGAASAADFTSAIDKGIYTSLLQLVNDTDAEALIDANAPLTIFGPKDAAFSVISSLLSGYTIDQLRDVLLDHVVAGVALDSAAIVEQVCTEVETVGGLKLAIKFEAAASSVTVNNIPVTDFNMEGDFGIMHGIEGVFVEGILGQFEPCPKPPIFDPLVAKGAYSTLIDLLIDTGSVSTLESNAPMTIFGPKDSAFAAISEYTVELSLEEVQGTLLNHVILGEEILTGTIISEGCIERVTAGGLQVGILFDSATSSLSINGVTVSDFNVNADFGIFQGIDQVMVQGLQGEFIPCPPFEADFSPIRNRGIYNALLNSIESSGADIDISASAPVTILGPNDIAFADVANIINGLNQQDLKDTILRHAIVGETIEAADIVEAGCLEKVTAGGLDVAFRYNQTLDQVDVNGIIVSDIGIVGDYGLFHGIQGVLFENSPGYVPCPAPTFVDLVEETGNYTGMVNFLLTNAQLQQELARVGPVTIFGPDDAAFAAVSSDLAQANNTQLVTIIGGHVVQQVYTAEQVVELGCVILRTVIGTTVRIMYIEDEGAVMVNDAKVILPNIQDETSIFHGIDKVIDSGEQFDCPQTPEPTRAPTAPVIPRPTVPLSSAPRSGLSIVFAASIAIAAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKV8</accession>
    <name>A0AAD2FKV8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000738">
        <property type="protein sequence ID" value="CAJ1938600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="314" mass="36607" checksum="A69AD960B1864C4F" modified="2024-05-29" version="1">MSCRHRLVAICLFLLYIITWAFSMSGVLNNRFWDKRYNLKRIQENDGAVEELELGFQETTKSYFSDVRYVYFLPHVIGAILWWNLYFLQLIPKIRRNYKKFHRMLGRFLMVVLLVQTITGFGLAATTKSHIVKLVSYILCCASIFCVAQAWRYAFWRDIPKHKHWAIRLVGYMQTIALQRFWIGMLIMSHSMGWDGLYPLLDDDSTNEEWIQMTEQMFDDSFVLSITTAFLFTEWYLAAEQGMTEPPADNRNNKGGGEEEKDQNDTSMRAEKEDEDEVVIDQVVDRAFNGGKGEAEKEGEMTTAQSDSGSREMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLW8</accession>
    <name>A0AAD2FLW8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="223" mass="25300" checksum="C45E327BAC0FDB89" modified="2024-05-29" version="1">MYKANSLAEFLKDDMSSFWEDDHSDGEETVAVHRSSGIRFSDTVAIQEILCISDMTTREVADAWYTQQDFKSMKAECRQLAKSVISGDKIERSSHICMRGLEEKLRQRHKKINRSEAIGAVLDEQEAQFGYGEQDPERIAHVYHEYAAHCLDEAIELALRDQESALKLHSLPSGSRSSSPEDGRCTSRSPAVPKAFCDIVADCSRKMPRIRKVAVKTRNEFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNB3</accession>
    <name>A0AAD2FNB3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001723">
        <property type="protein sequence ID" value="CAJ1947020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNB3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="326" mass="37731" checksum="CAA6B2EA596D429B" modified="2024-05-29" version="1">MLLRLSIAISCVEMVRVSSSYVKEGQQDDTELDSDIEDGNSDGEASVDEEADSYQVKASADRLLEEAPKEHYNKKTFFTLVQVKWYKPFCTFYPTKPKATKKKKKKTIIEEDEYDSGRVVDWAIGLDQNYINMAECSIAPALNAKMKEYKIADQWRPLEPLMRSQGWARRPMSGGLYGRNYMNDKFIKICFVQFNRGIVNKGDKQSPTQTLALMKEEHQGFYCYPGLHEIVWMFSSLVQQSKQNGNKIISFQKKSEPLVPPKIKAELQSMLDENPNWTLVPLLNEWKERFSGNREYDEEKVKKQATCLRAKLMIDLKRRLMRSMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNN6</accession>
    <name>A0AAD2FNN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS11164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CAKOGP040001728">
        <property type="protein sequence ID" value="CAJ1947479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="9">
        <location>
            <begin position="30"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1947479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="501" mass="55020" checksum="E183F5E660DA2E3E" modified="2024-05-29" version="1">MLAIKSTISPLTRRMGLRSFATGNSLNDSLSKVDPELTTLIEQEKARQRNSLVLIASENFTSRAVLEALGSVLSNKYSEGYPGARYYGGNENIDQVELLCQKRALEAFNLDPEEWGVNVQSLSGSPANFQVYTALLETHDRILSLDLPHGGHLSHGFQTPTKKISMVSRYFESMPYQLDPSTGQIDYDQMQKSAELFRPKLIVAGASAYSRLIDYQRIREIADSVGAFVMSDMAHISGLVSAGVIPSCFPHSDVVTTTTHKSLRGPRGAMIFYRKGQKALDKKGNPIIYDIEDKINFSVFPGLQGGPHNHTIGALSTCLKLANTPEFVDYQKQVLKNCTRLADELTKRGYDLVSGGTDNHLVLVDLKSSRSIDGARVERVLELACIATNKNTIPGDKSALNPGGIRMGTPALTSRGLNEEDFAAVAEFFDRAVSIAVDLKATDQGKKLKGFREMCKVGPSAHSDLPRLRKDVSEFASSFPTIGFDEDEMEFDGEYNVDFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNW3</accession>
    <name>A0AAD2FNW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNW3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1947703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14501" checksum="FCE3BB4C12B332C2" modified="2024-05-29" version="1">MEAKILLQQGHAYRSQRNHKKAKEIFQRALKIQMKDFGGDSLDVALTLNYIGNVLQREGRRDQALEQHKRALDIQLKKVGEKHLDTANTYKYIGIALLKQNDDEKAEETLRKALDIMDDLPAKCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU36</accession>
    <name>A0AAD2FU36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS13394</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001799">
        <property type="protein sequence ID" value="CAJ1952111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="14">
        <location>
            <begin position="28"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="140"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1952111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="488" mass="52523" checksum="2AFFF29309E23062" modified="2024-05-29" version="1">MGTYLSIPVTEKCEESGESLECPDVPCSWGVVDMQGWRKSMEDAHVAVTDIPIPQSSEDSECKSDAKIFGVFDGHGGAEVARFCSLYLVSVLTQQESWKQGVPVSDEQRSSDPSESTVGLALRNTFHSLDRMIQDSSRRDEIVTLRNSKPFPGERRGAVSIPADQTVGIIPKETNPSNKSSSESTDAGNAKGENEELAPTEGGNNTDTSDDDSTGRVGEEEAAELDRNLDGDEKRIEQDSNDTSDELDKKTATVTGMMQRILNLASSSGDKGVVPLNSEETNQSAGGPSAAKPTIVHNGRLICNLPDHPIHAGATAIVAVLTGRILTVANAGDSRAVLCRAGGKTEALSFDHKPQQQVESSRITKAGGFVNQFVPGIPPADQIITSEPDILQVVLHPEDEFIILGCDGIWDCLSNENAVQFVRDRINTRTPTEIGIEMLDEIISDDPRVTQGIGGDNMTIMIVDLRPSTRVGRRNPDSQLAANNETEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV37</accession>
    <name>A0AAD2FV37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="714" mass="79982" checksum="D3819C0893CB9B1C" modified="2024-05-29" version="1">MATAPTVSEADVILPPPTALNPIPELSAALRLDNQEQLIELLQRNPTPAAPFGGADFRQLLIFGSSSLRTLLLRQVLNDPHKRRSKEKQTKKNWDNVNTYQYPKSLQGSIAGTRLLEQTSLASSPSFSVATGLDGAAEVSFKDQEDDEFQHVDVLTYFVRPWDIGQTQAVTRKIHSWKKKVHHRIVYIPQPTALVMQILQDLGLAAAPNVSIASLQLDLFPIETDVYSLEYELAVKDDLVEKTPSTMITTCARALLKLQDITGKIPRIQSIGTTSEKVLDRFLNQSVDEYLSSPERDQDEEASTPLPNSHIAMLFIDRKIDMVTPMLTPLTYEGLLDEVVGIETGFIQVDVNTINPEDDVEKEDKKKSTNPFGPVSKKAEVVSLGVHAGDSLYAEVRDQHVEKFGSFLQNQALALRESHANFTNKGTKKDLQEIHQFVKQIPVFTQNLRSLTNHIHLAELIKAESEQVSFREQWQTERSMIEGEVCSDIMEEWICSRYPPWKVLRMLCLQSLCTGGLKSNRYDAFRSLIVESYGYEFLMMLHELEKSGLIRRKENFFIDSNSSSFASLRKSLILINAEVDTVEPDDVSYVSSGYAPLTVRLVQSAVQGWSKKKDIVEQLPGRILDIQQCHPPLDMNSTLKTQNPPVTTDSLGSYAKAARTETSKPVLFVVFLGGVTFMEIAALRFLSKRPSFPFTIIVITTKIINGSTLLQSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV38</accession>
    <name>A0AAD2FV38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="404" mass="45445" checksum="DA55F8087FC72BEC" modified="2024-05-29" version="1">MPLPPSLGRKCLPYNRFSLNTVQGYPKEQLLPGVEDRHFVADCVVMSKGQLTNERETIVIEQWQNEGIIEEFDEDELRREIAKDQKELDEICKDIERIDIRCRDWVAHSVDVEGLGKPWPDLVNSSREHRLKKEALGLVLDYLLDRNKCPYIGLGAYHLTDMKGIMLSCTDPTNPELPWDQMMNCMRKKEIEGIIGNFDKLGYAKHKRWNFLLGEQWFRESFGANIATQAVSSVCSHSRGKNNLTKAELVHYLKVLVGDAERPLEPTLPAIQAESSIQYSKQAAVPGPPQLITESSQPDQKVIVPSAAPNTGQAIISNEDFQRFQEWQIHNRASASDAQPGADSTRNVHNPISRGTWATRHRSSDESEDSMNYLVSNAQPGASSSRNVRGTPSRGAEPPGRYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVK2</accession>
    <name>A0AAD2FVK2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVK2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="775" mass="87360" checksum="A3B2010C7EAD8D65" modified="2024-05-29" version="1">MKSSRLALRSLGHFQRRYIRSRKLQPSNLSHQDVNEDETFHGHVSIRRFFSSSTSSNTPSIHHAQAREFLDKLKTGSFNTSIVPQRVEQLLIALLKGDNTANDGPLALQLLNSAIMHSNLPNERLIPRLFSLACQIMVRSGHSLAWNEVHHQIWRLLDGHKEFLINDIPYNTHHVNDACVQLISLTVSQYGRKRRMDHNTSQKIQQLIAELKRQYKDPKIPLGASVDGFNSFIMYYCDIGKPNKALEQLHWMLNVSSKSKQMLEPKLSSFSLTISGFANDSDPDKATEIIQWMLSSYKNKASPIPAPNRACFNGLLHAWAKSSRKDAGSKAERVLDWMQQLYESDQLDTQPDDISFATCINAWARSPGRESPARAEALLHKMLILHESGNGDSIKLSLSAFCSVMDAWAGSGDRAAPQKVDAILDIVEERSSSMEDFELTAFPYTILIKSWERAASGTKDRNRQLECSDNAFKVLTRMQNMGIVPPPTTYNATIMALNSSSPMNAIFYFLQLEEQYRQCKIKLDTRTFNCGLNAIASMMKPDAAEKATEMLSRMKEYATKDSYVQPDETTFNIILKVLSRSNLEDAAHRADELLQDMITMKSIRSSHVSFSTCIIAWGRSQAKDKIQRVEKLLVQFEKTQKKNQKAGKVGSNAVYNAVLSVCYHNGSGEFLDQARETATIAMQTLRNAKATADKATYESFFKVMTFAPVDPAKENLVETEFRRCIEDGLVSVDSLKVVKAVFPSVAEKYLGEHHGTNGESIPRQWSKQIRSGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW65</accession>
    <name>A0AAD2FW65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW65"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="40"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1954763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="473" mass="52878" checksum="2E843CC546DA5C41" modified="2024-05-29" version="1">MKKHLKKLQKKLSFSSRNQKERTPSPKSVTVLEDVEEPSEIIIVGAGIVGLVMALALHKHLGVKIDLYEQAQAFHDDVGAGMGMYPNGLRVIRDIDPELLKAVKAAGHPYVYRRWERHDGTEVAVAEERVLAGDDDDLASIGIRRWRLQKVLFEAVEKAGIKVHFRKRLESMKQIDDHVNLKFEDGTDTSCKLLLASDGSNSRVRKILTNDTCNLKYTGTQCLMGTSTLAREERGLCLPSSPTSKCHGAFYPVSETEQCFQFHFPVPEEEAKSSQGSWGALTEHVGHAECKLLAERLVKDGWDKKYLEPLYHMDRAIKIGFSTLDPPLETFVQGQVALVGDAAHPPVPYLGQGAQQGLEDAGTLALLLKHLCVSKNADGSHSLIMSQLHSALKLYDEIRVPRTQDILDKGTRWGKHQQKRAECEKFNKTKENMIQRDVFFHETMPVLKAGVEHDYKEAVMKSLPALSPVTEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW85</accession>
    <name>A0AAD2FW85_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW85"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041982537" evidence="1">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="25093" checksum="9C047FF61EAC129A" modified="2024-05-29" version="1">MKFTTTTALFSLACFFQVTEAFFGNMATKSAPSSSPSKLQISSLASEAVEIYNQKYPFNTERTSKPNPLGTIGVPTKDFDGTVLVKTRMKAPSVRKSLADITEKEAIASFNALAAVYGEERALGMVKTEPLSLAFDSSVFADTFAIWAEKFGEEETKDMVLRNPGLLSVQPVYAKKTDDSTMAFSYIIAATRPIGAFGPALIVLLVLTPVIEAVTGIPIRETREAFFANLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWU3</accession>
    <name>A0AAD2FWU3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001875">
        <property type="protein sequence ID" value="CAJ1955027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWU3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="172" mass="18580" checksum="BF840FF39403DE3B" modified="2024-05-29" version="1">MPHPTASILITDSGADQFLAGYVWRRIGITGRHIAFTGPIAGRDIGTVLPVSSVASKIIDAQGNTYCGKAHEILHDTNPHQHESLLPPALLPPAQARAAGNAVDECPSDALTPRGDYGTQCCVISGHTLLLFFHGFKCYYRVEAITDEEMRTSPEIVFTSDEEYEPSACSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXU8</accession>
    <name>A0AAD2FXU8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS16302</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001916">
        <property type="protein sequence ID" value="CAJ1956580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXU8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="118"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="403"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="562"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="215"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1956580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="831" mass="94010" checksum="76E3BA9E6498AFD4" modified="2024-05-29" version="1">MGRNWKRNQKNKYNRGGKKPKPADPSKYGEHKDPYKLISGGNYKLEAYYAYQDIHQQVFDSQSNDFLECRSDEQKEEERVKWLESMKSILPASFRIGRDVDVVLRDRLKKELESYVGKKMEIEVTPKGGERRNRELDLKSEFKMIAPAKNVTFIPHAYQLNLDRQTIRRNPSLNPFHEWLKVQTEAGFITRQETVSMIPPVVLNPERHHTVLDMCAAPGSKTSQLLEVLNLPANPNDKEPTGVVVANDSDNKRAYMLVHQLRRINSPALFVTNCDAQFFPLIRSKEHPSEGAFDRVLCDVPCSGDGTSRKNPGVWKTWNALNAFGLHALQLSIALKGASLTRVGGYVCYSTCSMNPIENESVVAELLRASEGSLELVDKRCDLPGLIARPGMSTWKVLSEDKSRRELKDKMKKKNSKMQARRREWEVKNKKENEVTGDSEQAGVDNEDMEDAEKVSDTDGESRVPITSAYKPTSYDSVELKKMAKMAGLNEYTSFDEVPIALQKRIRKSCFPPTDEETASFNLKHCMRILPQDMNTGGFFVALLKKVAPMSSRARKAFQQLENDLEEKTELPEREDGPKPKRAKVEQVAVANENDAKDCQEVSATSDCNQPPLNSENRSSATPGNVKKHYLSDKDGNKHPSLGRDDFIPLSKEIFEPLKEYYGLSSDSFDANQYMGRACGDSKVLYFITKTIRKLIDDGLQTRLTVVTSGVKGFVRNNKECDVGFRVSQEGVHFVAPHMTKRKVGVDLEDFEKCLQTETILLETFSDEFASEVRSLSMGSFVVYLNGFEDDYIKKFVVVMWRCRGDAVNCLVNKAELNGMKSKVRSVMGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYC2</accession>
    <name>A0AAD2FYC2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052736">
        <property type="entry name" value="Stf3_sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36451:SF1">
        <property type="entry name" value="OMEGA-HYDROXY-BETA-DIHYDROMENAQUINONE-9 SULFOTRANSFERASE STF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36451">
        <property type="entry name" value="PAPS-DEPENDENT SULFOTRANSFERASE STF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="427" mass="50088" checksum="E56D334409373458" modified="2024-05-29" version="1">MVVARSSAADVLQSFDHYSSTDETFTYNFRPKFQKSTKNNPMSGICLFAWIEILSKRWRQIDYLTYWPRVLMISLLSIFNSLLAIVEHLLFESSIRQTTPNPRPVFILGHPRTGTTLLHSLVALDEGQFDVCTTFCAGFPSSFLWFEKFGKQLFKGILDETRPMDNVVLDFDLPQEDELATNLVSAGTSPYMPLFFMPQEAQFRPYYAFDDHASGDEKLQPEEMARARNRWVNTFYYLCQKLTLRSLRTKQAALRLVLKSPVHTARIPLLLRIFPDAQFIYIHRHPYHVFQSAAHMADTTYWYTYFSTPQHEEIQEFILRQYEILWDRYEEGRKILQQQMAKTDGGAKQLVEIAFDDLSQKPFETMDRIYNELGWDMSSEMKRSLEQTVSGDIKSYKRNKHETLDPKLRATLQERWGASFDRLGYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYV2</accession>
    <name>A0AAD2FYV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYV2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="40"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="39304" checksum="0BD243666DE89248" modified="2024-05-29" version="1">MKAAVATGIEDVDNHIHVKEDWPKPTLATAIDSKTGKLVSELKDAHLIVRVLACAIAPGDCRLFRGKTDMAQLPKYGRPYVLGSDICGIVMEVDDKNSYFQVGDKIIARFAEPQPVGMCAEYSCVKTEFSEKCPSSIPAIHACTLPSSAAAAKNVAEGFVSKGDRVLLLGASGGVGTFLSQYIKLQGASFLAATTTQAKLAESLGVDRIIDYRTENWWELESEFQGKPFDKVIDLVNGENWTRGARSGTKVLPKKVPYVQLIPGVGTEINMTGLGIGSFLGSMLGRKLVSKCHPSCPKWEIPQGLDLPPGHLKKVLGDVESGKVRVILDSAGPFQFTSAGVRAAMRLQQSKHAHGKVVIEIAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYY8</accession>
    <name>A0AAD2FYY8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sodium-dependent phosphate transport protein 2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS16915</name>
        <name evidence="10" type="ORF">CYCCA115_LOCUS16916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYY8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037997">
        <property type="entry name" value="Na_Pi_symport"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1957867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1957869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="61322" checksum="23A756007DAF706E" modified="2024-05-29" version="1">MSEEKPVTSRKDRPTGSMHVGDADFDVNDPAYEMDATWGEVCTACCVKTPTEWAFGLLGIAAVFFFLYFFLLGLDLLGEGAKVMGGCAAGALFGDDMNPIAGLMVGIVATVLLQSSSTTTSIVVSLVGADTVTVKQGIFMIMGSNIGTSVTNTIVAMGHMGDGDQLERAFAGATVHDMFNFLSVAILLPVEAATGYLFHLTEALTTNFKAQDGEKWEGPVKKLVSPLASRIIMVNKKVAGDIASGKATCDTYYPNNGTISCEDYSDPLTCKSGLLACDTKADVPFCPAFFDPEATESVDRTSGVCAFIIGLILLFICLFALVKILQRIMMGASTRVLYKATNINGYLAILIGAGITILVQSSSITTSVLTPLVGVGALRLEQMLPLTLGANIGTTVTGFLAALLGNKNGMQVALAHLFFNITGIVIWYPVPFMRNIPLNAARALGRSTRLFRGFPLIYIAVAFIAMPLVFLGISYLFSDGNSGLTALGSIIVIILALAIIYTGYFCKYQGGSEKCTECLVTREKRNNAVSNLPDDMEWLKAKVRELSEHTGLSVDEEAGADEASDETEPPKEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZD0</accession>
    <name>A0AAD2FZD0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="130" mass="14703" checksum="22750D6507D709D1" modified="2024-05-29" version="1">MSAKQDELLLRTPMAERTRQTDINAMISDIDSDAKQRSKVEKKNAAKIVLDLSPRSLVDDFQLTNKRRRVSFESYPISVSALLDESSPSTPVRLGIRCIKLGFRHRNDLRIADSYSISSPSRIPLLSLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZY9</accession>
    <name>A0AAD2FZY9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZY9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="347" mass="38946" checksum="A8B4C8577B25DC24" modified="2024-05-29" version="1">MVEISCVLAAVFLMTGNILKIVYYANVFRDNHGTFDWETYTTLDPGFISAQWETRISRHNLFLASGFMNTIGWLFLAYPILQMAWILSKGGSRALVLNVVIGLLCLAGAITELISNFVWLGMSYMSEYMVYLYGINPNEGDWLDRPDMPDDDGYGWRVLEMVHIVCRGFIIYVDSFEWIALAGVFIFTFASVRGWLQEDQTSFGSRWNTLGLFIGFVCILEFVAEILRFEENMRFSSRIFGIVSIIYAVLNRIIFIPAWILSLGVMIPRATMKMAFENPAHRQNGGGGGGGGGELQMTEIRPESAAHDGNDFTIDDVEEEEDHPPTTKDQGPARSPPPAAFTTTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G050</accession>
    <name>A0AAD2G050_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G050"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="323" mass="36141" checksum="D38C5185CB3E45A8" modified="2024-05-29" version="1">MATTRRSKRIESKSAREEHVEVENVVTATTNEDDDDDDDEAPEEVSTPEPGKNSKKKQTAKARKQQKKEAMKSKATGVGLKISIEAAATKNKKIVFGDDEDVEDEPVEEEGEPENDDNEEESDDDDDDAIEEVTGSKAREDILEQLNVEEKLATKSKKKRKKRERKQVEDEEGESDDEFDEAFFAELEAAKAEEQRELAKTKRKGKHTTFVVSHDEDDMDDTPREVDDNIQVVVLKNPLQDSTANAIAAVPTNKLSQQATMFSRGSLDNGSDGVARGATGKKRKWQVDNTWKRSKKMKNMVRVNRGGRGGKNKSLAPTIFVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0G7</accession>
    <name>A0AAD2G0G7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0G7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041975859" evidence="2">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="294" mass="33260" checksum="3CBEBF585BFFE8F7" modified="2024-05-29" version="1">MLKIIISLLLLSQATVAMQIRVQNMTCEEKSITVDFDRLCTNESVCTVGKAANLVGSLTYHYLNEEFGMNQSSKVYLNLNMSLFGREAASKNFSVHKPIYEGTFFDFVELPLCDNATLIADSDDAECPGTGTYKFTNSIKLPHPNNAFQTWMFTGYDGLVKLGIYQSEQYDSEPLGSCTFYVTTEQGQSRLGNLPNGKPVHDAVITFVAVFLWLAAFAVCCLVRRQRNRKHVEAQEVQKVVRPRPLTPEEKVEGRFRRLEEETQEEQHRTFAFRYVPPEDDPVPPSAFERACLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0T3</accession>
    <name>A0AAD2G0T3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0T3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="195"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="394" mass="43938" checksum="09A13232264670A6" modified="2024-05-29" version="1">MRSRLSFQKDSFGEDQNLSLCSTSSTGEESSSQYSPLSKSLSIAPLSPPSSPMKVKTINTWCKTWCALPLILLLDLFCSLVFLKYEMVLDPGFAAKIANAEGKLHHVDKINIVAGKTLEEEVQNVMIGTEMAFNISQNLLPQAVVMLDPTPKAMQSNLRANSNDVQQALNHHKYLIPDSEWYVDLGAVDAALESGDGCIVYSFGIGKEDLYTSFMAEKGCHVYAFDPTQTHPRYWKPNVEFFSWGIRNSEGTTNVGWSHPKYGHLVGSLFSLPEIVEKLGHQNMAIAALKFDCEGCEYGAFQDIVDYEQASDQRFNRIGSLTTEFHFATTLGMESLQDVANIKYADAFLRSQDCRVIHYKPNKGFKKDRTVHAHLVKNGVPDGVCCYEYGFSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1H3</accession>
    <name>A0AAD2G1H3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS18127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1H3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000006">
        <property type="entry name" value="Divalent cation efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="182"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1959708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="686" mass="74007" checksum="66AD8604A5D9EA28" modified="2024-05-29" version="1">MMSIHGSSTRLFHMGHSHSHHDHHDSNNDNDDEAQQHALTPQQKQMRLRRKIALVTVVWMATCGSALIWKGRLAKSDWMAFGIASVAFSSADKTRRAIRSYIQKLARLKDGIVKHSPRIDYNLIADSSSSSSSSSTSNENNNHYNGMSSSSSSANHNNNNHNSGASNDKLRNDARDADRVTWLGAVINLVLSVGKLVIGITQHSSALVADAGHSLSDLVSDFITLWTVKVARLPADEDHPYGHWKFEAIGSLFLSLTLIATAISVGVMANKQLIEILHSSSSSGTAAKAAAVAAHGGHGHSHMIVPGKLALVMAAISIASKEWLYRITKKVGEKIRSQVVIANAWHHRSDAYSSILALLSIAWARTGVLAADAAAGLLVAGMIGMTGGEILMESVQQLSDGATPWLQKECEEHCQELWKKDSDDVDQISFVKARQVGSLSLVEVELLCPPHLSTTASRAVEERWNFWLGELYGYEATVHTRPTTTNDNDLIVRPLLEQQREMDSAAAGQVVGQQNQKQHGHDHNHDDSSTTNPASTSTSSNGTLQDFTVMKTTHNGMAMEDGNSSSSSSSSVPIMTTSAGKIETLARKQVSLFGGGSQVERVTVHYNPGYETSVDIILSSPPLSAATSSSTNTPPSPLTEESLPNLVENGATLKESLQSLIEIDNANIYWDLSSISLPGAKKKMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1U8</accession>
    <name>A0AAD2G1U8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1U8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="140" mass="15996" checksum="B3E9544E593023CE" modified="2024-05-29" version="1">MCQQKRLHAPTPTTTKEKFKHAPTKERQEETNTCKRWNSASFHAISTTPPDNCEKYGGWSVHVTEEEGYLCELDTGVLMPGGPLVVDALGGKVDTASCRERTYYSREKKWCSDNAMHWTLLIKRSRMSEAKEEEEVLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2E1</accession>
    <name>A0AAD2G2E1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17993</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002057">
        <property type="protein sequence ID" value="CAJ1960270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2E1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19237" checksum="21D38179405CA768" modified="2024-05-29" version="1">MKPWRNSTKHFELAIRLEKLGEKHVDTANVYMSKRQLLPNDHSDVTVLYHHLSYSLERQGKFSEATKMHKLQLAPLLEMHGEDHPEVVRVYTGIAELLRLQNRLADSLQMLDRAMEICNRFERLGNLDRDILLVTLGHRSLTLKGLGNLEAATEALNKSANDTDGNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2F0</accession>
    <name>A0AAD2G2F0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS18590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2F0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="531"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="776"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1960174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1159" mass="129645" checksum="F560350B24BA57A3" modified="2024-05-29" version="1">MAEDWHSIASRSQYTNSQPSEFLSGTSEVSVDTASVYHPEVAEQEDRAIARAKLSVAFVLVLGVAGLAVGVYTLVNDQEQEGFQNNFAGYGSEVIQVAEQKAAQLFRALDAFSVGVASAAKAKNESWPFVTIDDWSLKAKKLIDQADVSDTAMAFLPIVQSDQRENWTAYTSKLAPKYYQNSIKNEGRNVTVDYYMENTVPYIHFYNVHDNFAVTPITWPSFSLPVWQVYPLRTGAIVPEIDLLVTNFDIAIEPTAGNLAATSIAARSPTSDFTPLVEDVTTGKTRALSAILQPVYEEIDTDANDRRVVGFVWFRLDWALYLQNILTENTNGIIAVIRGSCPIIDVFDYSFGQSSEGQNFAGLVLSYRIDGPKATFLGAVDAHDPEYNGMEESGVFVDLDIDPANVPEGGCIPRMTLHLYPSGDLEKEYKTPNAFIFAGFVAAVFVFTSLVFLVYDYYVKKRQKKVMDRIIQQDRIVADVFPSAIRDRLYGHPKDEKQYKKGSAFDLLGYEQESASVAADAPLADLFPNTTVVFADIAGFTAWSSAREPHQVFILLESIYGAFDKMAYRHGVFKVETVGDCYVSVAGLPDPIDEHAVVACKFARDCLRKMKQITVKLEVSLGPDTAELDLRTGIHSGQVTAGVLRGERSRFQLFGDTMNTAARMESSGERNRIQLSQATANLLREDGFSKWIVARKGKTFVKGKGEMQTYWMRTGARVELGESDGVKKVYETAETVEEKSEDFDLEIENFQGMSKNERLVEWHIEVLSTLLEQIIASRGGNTKTIDNLAPSETSLGRDGNVLDEFIPIIPLKRLNEEELKLRQNPSSMGIGENVKLQLRNYLLGIAGMYRGNPFHNFAHASHVTASVKKLLSRIVNTGDGNGLGRTNRRPSVNMIDLAGHSYGITSDPLTQFAVVFSAIIHDVDHPGVPNTQLVKENTRNAQIYKKSVAEQNSVDLAWDLLMQKEYATLRACIYHSEEELKRFRQLVVNTVLATDIVDKELQALRKNRWETAFSGAVENDNSTLNDDRKATIVIEHLIQASDVSHTMQHWHIYKSWNEKFFMECYGAFKAGRAEADPSIKWYEGEIGFFDFYVIPLAKKLDNCGVFGVSSDEYLNYAQGNRDEWKREGKQLVEEFRTKYEENARNGKGDNEHWISSIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2Z4</accession>
    <name>A0AAD2G2Z4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2Z4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="84"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="493" mass="56349" checksum="6A57BCCD0DDA3E42" modified="2024-05-29" version="1">MKKESADNNDQSSTQTDTYIEREAQKGDEIEPLGDAGVELVVNLEGTIDALIEKEVIKLSSQCRLFKDETNAEDELAVFHRNEVLAGEFLGNGAFSEVHQVWGFQLANFGSRDPKQERARLELCSTTYDQNGESAYVLKHLRRDLHHRGANKFIHAAGDLVMEAKFLSYFDHQNIIKLHAWSGPTTAYHGNTHDACFLVLDRLDLTLSHKMIQWQMNPQASEAVYSPNLCDYNEKLNIGRQIASGLEYLHSRDIIFRDLKPDNIGFRGNTVQLFDFGLCRELPESKPIEEKTFHMSGVGTKRYMAPEVFLGKHYNLKADVYSWTIVFQSMLSLQKPFDMFDAIHYKDLVCEKGARPPVFQEWPQGIQDLCRNGWAQDPHDRFTISEVREEIERMQAQMPAKGQHGYVAEVTGGNETPFFIERSSSFDQSSIEDMMDNICSPHRICLRIQGVEAPKGGQSFLRMIEGQMIRASAPYERHITSYPNLKHLRSQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3F0</accession>
    <name>A0AAD2G3F0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS19172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3F0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF30">
        <property type="entry name" value="OS06G0587000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="628"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="551"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1961389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="962" mass="102059" checksum="102293003B329939" modified="2024-05-29" version="1">MDENGVKSSNDKQVMSPSGKSHHHPANRDSGKHGRKDRHSTEGSSSQHEEDAKAKERARRPRSSKSPTRPSTRPSKNAKDRASKDRARRSRSPVPGAESVSRSSPHSPTRSEKDAKRRTRRSEKASKPGAESVGGIDRIGDAKASDKKGGSSKLAMAPGMESLSEETDNRTRRENRKAGRKQAMSGTTKKSSKEESHKQHILDKEEPAREVGGDDIPIAAIAVDDDDKNVQVGMDTQRQQAMMANGASEIEGANNEVVPDQKRTIFSKRNICILVVLLLAIGGGVAGYILSQSSNDAAVESTGDDGTTTTDDQQDTDNLSGTPSTSPSLVPTEALSTSPTTIYSPPSDEDCDALRNGQPIDLGDQEYRELVFQIEMDVVLEESKDSTAGMEELVGRTQSVIVPILVGCPEVSRRNLIETTQSIRRGGRRLLKKFEIAGATFKLEEDGNLSCVTTDSELPCYRPVVNLKVFVKGDGKIIEILGVISQALEANSGLTTLLEKLGLIDEGFVSILNIFIGDRNKTDPPSSEPSSTPSAMPSSSPSAIASANPTFAPQTEPTASPSMQPSTATSQGPTNTPTVTGSGSPTLSAVVGPSPPPSNMPSTMPSVIPSVMPSNLPSFLPTHIPSVVLSGTPSTDPSLNPSSDPSASPSTMPSRTPSRVPSPAPSENPSITPSMSPTVEVGPILMDIYNAAGGSFGSSSTGWQGTGDWCTWDYVECDSNREVTTLNIAYLGSSLSGTISPRIADLTSLATLILSGNRLGGTIPSLPTSLVYVNFEANNLLAGSIPASFYSLPNLIRAEFAVNQLTGSISSLIGGMPKLNRLVLYRNQLTNTLPPELGNVANLRHLVIRDNQFNGSLPSELFALTAMTRIDVQRSSLTGSIPTQLSGLTELTRLDLDNNQLVGNLPAGMEAMTKLTWLRVHNNQMTGTIPPLKSGGNTFGVCDLSNNNFDDTTNAALAGCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3H1</accession>
    <name>A0AAD2G3H1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3H1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="209" mass="23525" checksum="C350817F735B2DB1" modified="2024-05-29" version="1">MNQSQPTMTIIRKRGVTINPTVKAVEVLSIYDYTPSEIAAAWYDEDDMQKITQRCFKVLQRMEECGGTKNGQKYCTRGLEGHTTLGSISKKKTRTAAFAAVLNEQARQWNENEQVNIQAISYAYRKTSSSSQMWAQVIGNQDRQAADAYLYADEEEDEEVDATRPMRTTTTRTTVSISALKSPVSQKRIRKVESAARQKGIKQKSARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5H4</accession>
    <name>A0AAD2G5H4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS20168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5H4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1963450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="699" mass="77340" checksum="F4EEA19209EDE386" modified="2024-05-29" version="1">MSCHPNEKDIDNDEPQMVPVTYATVSSAHDPQEFSEAQTIVVGIEEASSGLLQHPQPRQHAPLPHGRQSSPPNTDASIHPASIQVVTFDEQPTNGDDVTGGMEHDVSGLGDNSVRQESTPLLHQNGGAVDLNINALTTENHPYANDFFDDDITSDGRAKCHDLTWAVLFWAHIATVVYAGTQLAPQGYSMMQKNDFDLQQLHDFMQDNFITDDFTAKDLDQLTHFLYELQVWWGIYPIRILWFGIAVAVVSFGLNMFKIYFIIRAHTPFFVAASLIIPGGIFGCLLILMMSDQGLFGFLFCVTVLGFLALYIRKLLWPKLHFAALNLEIALTGIGSNMGTYVWTFAMVEITVLWIVFWCYTVLGMIQYIQRTQCPDIKFDPQSDNNDTCGPSTAVLVALLFSLFWTLKCVGNTVQVYVSGVMATWCFDKETAQGFCSSAVTSSMYRSISFSSGPIAFGSLFQGACKVLRWILGHSNRNLQDANDDCRCCCFCICDLILECLSELFGDVLEYFNQWAYCFVGINGTSYLESGKAAANLFKQRGWTALITDRLVALVLGFGILEGGVVTGLVAIAMERLVTWSTYRDDHADLPESYVLGPLCNVPMATFLFGFVIGCIVSGVMMNVIHGAVNTLIICWAKSPETFTDNHKHWADRMTTVWSSAFPGSQNRDGGRVTDLSDYTTSEETSSFRGYGAIGTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6V6</accession>
    <name>A0AAD2G6V6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006970">
        <property type="entry name" value="PT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04886">
        <property type="entry name" value="PT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="420"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="676"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="772"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="840"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1174"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1260"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1270"/>
            <end position="1294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1451" mass="137477" checksum="5EBF797B3EE8BB36" modified="2024-05-29" version="1">MVLLQYPLLVRQVDQRLSLLVLQQQDQLAPTRYPSSEPTSGPTSGPTSGPTPGPTFGPTSGPTSGPTSVPTSGPTFGPTSGPTSGPTREPTSVPTGGPTSLPTNGPTSGPTSGPTSGPTSRPTSGPSAGPTPGPTSEPTRGPTSGPTSEPTSGPTSGPTSGPTRGPTSGPTAGPTSVPTSGPTSGPTSGPTSAPTSEPTSVPSAGPTSGPTSQPTSGPTAGPTSVPTSVPTAAPSSGPTSGPTAVPSSGPTSGPTSEPSSGPTSGPTSWPTAGPTSVPTSGPTSGPTSGPTSGPTSGPTFGPTSGPTSGPTREPTSVPTGGPTSLPTNGPTSGPTSGPTSGPTFGPSSGPTSEPTSGPTFGPTSGPTSGPTREPTSVPTGGPTSLPTNGPTSGPTSGPTSGPTSRPTSGPSAGPTPGPTSEPTRGPTSGPTSEPTSGPTSGPTSGPTRGPTSGPTAGPTSVPTSGPTSGPTSGPTSAPTSEPTSVPSAGPTSGPTSQPTSGPTAGPTSVPTSVPTAAPSSGPTSGPTAVPSSGPTSGPTSEPSSGPTSGPTSWPTAGPTSVPTSGPTSGPTSGPTSGPTSGPTFGPTSGPTSGPTREPTSVPTGGPTSLPTNGPTSGPTSGPTSGPTFGPSSGPTSEPTSLPTNGPTSGPTSGPTSGPTGRPTSGPSAGPTPGPTSEPTRGPTSTPTSGPTHAPTSGPTSGPTSGPTTGPTRGPTNVPTVGPTGRPTFGPTSLPTTVPTSGPTIGPTSGPTFGPTSGPTSGPTSAPTPDPTSGPTAGPSTVPTSGPTSGPTSGPTFGPTSGPTSGPTSGPTRGPSSEPTSRPTLGETSGPTSGPTPGPTSGPTSGPTSVPTSGPTNGPTLGPTSKPTSGPTSGPTSGPTAGPTTRPTTRPTSGPSNGPTSGPTIRPTSGPTSTPTSGPTSGPTSGPTSGPSIGPTSGPTFVPTPGPTSGPTSGPSGPSSGLSPSSGLSGLSHTEALDLTSGPTSSPTLGPTSGPTFDPTEGPTVGPTSGPTSGPTYGSTSGPTSGPTSRPSSSPTSGPTSEPTSRQTLGPTSGPTSSPTLGPTSGPTSDPTEGPTVGPTIGPTSGPTHGPTSGPTLGPTSGPTSKPSSSPTSGPTSEPTSRQTLGPTSGPTSGPTLGPTSGPTEGPTVGPTSEPTSGPTAEPTSGPTSTPTLVPTSGPTFGPTNGPTSGPTSGPTSGPTIGPTVGPTSGPTSWPTRKPTAGPTSLPTSGPTSGPTSGPTSGPTSGPTSGPTIGPTSRPTASPTIGPTNDPTTKPTSGPTSQPTSGPTSGPTTKSSLRRRLIDQDPPSPCMYGAEANLFAAVGVGPKECADKDNMIDLDENDLPIQIIDQNQNGDDVTFKITQHYYDGIIKKMAFNFKRGPMDTACEVNSEISLEWSETYTAVCFDGKATVEIYLHFCEGEDIGIDYCAPPDSLDDYLALSMQLDCYETCEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8M3</accession>
    <name>A0AAD2G8M3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8M3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="230"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="347" mass="39279" checksum="44736628A48CC21F" modified="2024-05-29" version="1">MKKQKQLRLLAFMPKKQAKDDTGSKENSLNEEWRQPASRKRSRSAQSQSDYNKSTGVASIFERPKLKPKQTDLLAENLGKLLGRNPQYLASGSDGDPVSWILHVPNWFPSKAGATGRLGISCGANITDPSCAKPVQDFQAEWNLHPTKRKQLKIFGRPVSENRWSQAWGKPMDYSGMIDDSDRPLDQSPNLPFLIQQVNTIMKSATSDNGEEHDQNDKETQVNSGRVYHEYNACLQNWYQPDHSIGLHSDDESNLYANYPIFSISWGGTRRFLLRPKEVKTSAKNGTNKQKRVTPAAEPVEIWLKDGDLLIMGGACQKTHKHEVPRPRKKDPVTVDRICWTIRAIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8M4</accession>
    <name>A0AAD2G8M4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002234">
        <property type="protein sequence ID" value="CAJ1965869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8M4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="122" mass="13973" checksum="71880397359EEC6B" modified="2024-05-29" version="1" fragment="single">MGKSKNNKKVAIAAKPVDSTALTQGRISFLQKSRVETAEIRLKRESDDLDPPIVNNNSDTEMEEVENPLKYDRIVQNIDSSQWNLQTLAYLCTIHRARGQRNNKKEVVFGNKLFLAWENEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8N3</accession>
    <name>A0AAD2G8N3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8N3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="168" mass="18119" checksum="0DFD319FE6CF9088" modified="2024-05-29" version="1">MAYVYQSPTPTNEALVSLNPPPLPRKNPCARVDANLMPTTSSRPGLSFPSLDRLGNSAYENEEQTSLLPSLAPSLAPRRHSAGPSGSGLGLPFLGNIEDCSNRAGLFLPALAIRRTSCVGFSSSLLTEKEQGHQTSWKSKKRDASSFSLTPSLRRRIKRKTSVHALCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8T9</accession>
    <name>A0AAD2G8T9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8T9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="424" mass="47696" checksum="07D129AC61BCC6EF" modified="2024-05-29" version="1">MKRRASITFLYYLIYCRLAVCASLLLLVEFPSAGLAFDSTSKARKTFGRKDRPERYWQPKIRLQPASSALFASNPLEEEIASWAKDAGYGEVESCVNSGRSGWASFYKVHVSHPPKPNMAFFVKHAKSRQAHEMFDGEALGLKAMYECSSHTTVQDGVDDIRDDQGTSSTSSIASLKIPQVFYSGDVESSEGSSSGSLLIMEFLFLGPRRDDYAFGQAMANLHLANPVDTAPKAGNPFGKFGFPLDNTIGGTPQPNPWTHCGETKDWIEFYGTHRILHQLELAEDEYLIQLWKEDIAPRLDRLFEGIQVKPSLLHGDLWSGNIGSVRILEGDGDGSKPTIYDPACYWGHHEAEWGMSWCASLGSTFWEGYRSILPEDEGFWDRKPLYDAYHQLNHYNLFSSSGYLNKARRQLETVKKALDEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9X7</accession>
    <name>A0AAD2G9X7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9X7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="796" mass="87270" checksum="0E1CC6B1F72ABFCD" modified="2024-05-29" version="1">MSNMENMLMDDSSSGESDDEVVVPTNRPVASAIAAAAAPQAAPVAAPRPAAVPPQPSAQDQQKERLKNLYRAQQTMRPQPSSAPMQPPPSLSESASPSMPGPGPGPGPGSHINHPGRRMSSGSYNSSHQRSYAPSPQQPTPTTQGGPQPPQMNMTRRPSQTRTQQPQMPQRSQPQMQQHPQMSSHSSAQYNPHSRSSHGSHPSQSSRSQMVPPQSARTSSHPTSHDPYAPAPYANMQSREQPRQTSMPSHTSRPSSSSSYPSAQPVNPSAPVQSSHSSSGRPPQQLSAQEQAAQATRRKRQYTLFTQVLLKRLEKENPSMHRAAKATIQECAIRNKKKQPGYESLTNALMPRLKELVGKPFWNTTQKVLHNHLAKHKSSEAIKQQQQQKAAQQQKLESQNQQQRQREAQVHAQRQAQLRQQQQQQAAQPNLSRLQQEVTNRKTEINRAAPTSSAAAAKLTSTQKKQALAKQRGRVTSPSPASRKPGTPAAATTLPPTKVEEPPKEYNELMQMVDQAVSYDYKTAGTLLKASKTDLHVDDEQKRLLYGDVKPKLPPPRTQGPRPGWDKTNVLSARAAWARVRLPEQPEAAPGVPMTRPSAARGQNDTSWAHEQKAEQDEVLALLSEASQHYLKDILRKAVHCSRQRQNVDGIRLWHQQHVSAVHGKEAPLSLRLGCDVSRQVAQVAGNAALTCKRMEEALERKSGVPASARILKEATLQEATSMGDLALKPQLGRGPANAELQARRSFEEYGGKHASEPPLGRVPKKAKVEIVDLVHGQTLLQTLGHRAVTSKVTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAA5</accession>
    <name>A0AAD2GAA5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="394"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="493" mass="55629" checksum="603343417009BB1B" modified="2024-05-29" version="1">MVMEEEHPMDEPTPKVVLETLKAEEEAKEVPAPAETAPDTPMDEMLSDSKSVRSAVSSKKESPATEEQVEEKKPEDKPVESVETPEVEEEKKEEEGAPAVAPTSEGKDNKAVKEAVEVEKEAEEDKESAKDEAAEVEDVSEEAKRETSKLKNIFKSIKSIKKKVKKMKTKRSSKNKEASPDEVQEPEPNPAEDHELDVPKLVDNKTVEDKLVDDSANPAQETPEEEKEDTDDEAAENEEIINSLRGTVLSLDEENKELKRRIMRMKAQLSGEPQQPFDERVTDTLATKEFENMSPDEKIKQLDSQVQKWQKLYLESNEIGASRIEKLEEGCDEVSTMAKSTSGNTNDDKESMGNNEDRILMLEYQLRESVKVLKTAQKKMVAQHEKEFHLQKTVDDLSEQINELNGQVQKANDSEANMKVQWEQEQKNKLEAEAQLAQERQRLDDFREDLGLAPLYKNEAAVVDDQVDQQIQQTNNSSIFCWGGGSSAQPISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAR0</accession>
    <name>A0AAD2GAR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS22552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="10">
        <location>
            <begin position="46"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1028"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="364"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="722"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="856"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1057"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1966981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1340" mass="151761" checksum="C730383ADA4BD2C3" modified="2024-05-29" version="1">MSATEWEQSKENAAPLRRGRKVETLAPKAFGISNRDKTERVIDKFERLVRPSEDPDVTEMENDPLEHWLSYIKFYQESFPSDTHEQFLLMERCTRALIKMRQYANDDRFIGVCAKYADKTKEPMIVFKYLHQEKIGTESALLWIAWAFVAERNNDFQFAEQIFKKGISKNAQPLQLLKTRHRQFERRMSRNWMNSSQQSDQIDDEDDDTERRSVLGGTSRPRRGTSMMRQTERTRTFGVRQNRRSTRQTSNANSNTSTTNDFSVFEDEETGYDGYNLDQSHGTGRVIETHAERKKENTMEAERWNERGGLRRGQEAHQRSHSKGPPPAFAVFVDEECVAQHEAEEVTNQAEADHHRRCRDDRTFRERDDEGMGEKLAKDPLRYLRDRTQLESDTAVDSKQKSELAKKPAASVPKSKSGRKQKKGTGFDLRLLRNNQGDEQSFEEARANAKCFFLLPSSENFNLLHTVVSDDQSSQMDLDESSDGMSIGEFPEGLATNTSNPHNSVDARNDSIVSKKSVFGASSFDGSLNRTAISTASSTVDEIGAVGVPTRKEEETINTKFAMRELSMMFSSPAVGADDMVRKTERAILNKSTSANDSYDHVMNIMDHQQMNNSIFNIEEDENNENDGERNYEGRGSSSPGFHEMALKEIEGAQDAANSLSCRAQQRRGIPGELSQENPLSRNEVELHSDAGFQIFEEDRVNENQAIASTKAKSMFAIFQDEDDNTRTKPPAAKASFGIFEDEVETKEPKPPASKSTFTIFDDEAESSTSRLSKEKSSFAIFQDEQDSTAVQSFSRESRNGRSSKAPGFSIFDEEKRISSANDVKQSPQSSHTASDNGETATLSLFEGAIGMLAGNDDSNCSGRSEPSVNEDRKRQSSGDTASISLFNEAFAEFGIETSEKGLSQEKPPSASSKKHKFDIFVDESTRDAKRACRSRFQQKRRDPIDIDADRQNASVDYLKVHEHESQEALQHLQRSSVVPRSNVSLTDLLSSAGDSFDLPHLLVPKLLLRKSVIPSKAKLCIGGKYSGRICNELGRGTYGVVVLMKKHKTEEVMAVKSQTPTSCLALEYQNLRRLEERVSSKQGCHPFPKPLSFISLADGGILTMTAGSKSGLNLVDMVNIYRVKLGETVPELLALHYTSRMLKHIETMHRHGRILHCDVKPDNFVLCKLDCPDNAYRQIEYSDLFLVDFGRSVDLDLYSNQFRDARNAMFRGNASCPEARCIAMRNGMPWSYDIDTFGILSSAHILLFGNHMELRQSRDSRWHIQHRFRRYWNKDLWSEIFNSLMYPDEETGFALESRVRNLRSLYEKINDCIKGDEAKITALLKRQAALLPKRRDQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBI8</accession>
    <name>A0AAD2GBI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002396">
        <property type="protein sequence ID" value="CAJ1968648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21970" checksum="985B7556CE81E138" modified="2024-05-29" version="1">MAAARIAWRNYIRDVLDFSQDEAQEIVIEQGGRKSLRVMKWMIDASFAVHPDFKSHTGGTLSFGGGAAQVMSKKQKLNSRSSTEAELIAVDDVVTMILWTKLFMEWQGYPIEKNILYQDNKSAILLEENFCKSAGKRSRAINIRCFFITDQVEKGNVKIEYCPTDDMIADFMTKPLQGEKFRKFSNLILGPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBU6</accession>
    <name>A0AAD2GBU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">signal-recognition-particle GTPase</fullName>
            <ecNumber evidence="10">3.6.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS23599</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18539">
        <property type="entry name" value="SRP_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041974701" description="signal-recognition-particle GTPase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1969226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="569" mass="60660" checksum="080F857014919841" modified="2024-05-29" version="1">MKFTRPSLVLLALAASCHAFQSQSLSGSSFTTGGFQVRVSQPVRKDGTQLNMMFDQLTSALTEVAKNLGPKQRITESSIKPALRQVRRALLDADVNIDVADALIEGVKKRNLGDEVIKGVSAEQQFIKSMYDELLDMMGGDSKSSSPMGGVENSAPAATLAVGEVGNPAVILLAGLQGAGKTTAAGKLALYLKEREADYSAVGETDEPVVATKLPKRNRKVLLVAADVYRPAAIKQLEILAESIGVEVFSMGTDADPVDIAKQAVQKAKDEGFDTVIVDTAGRQVVDKDLMMELKNIQTTVKPDETLLVVDAMTGQEAASLTAAFDSAVGLTGAILTKLDGDSRGGAAVSVRGVSGKPIKFVGVGEKTADLEPFFPDRMASRILGMGDVVSLVEKAAAQVSDEEAKKMQEKMMSAEFDFEDFLSQAKMVTSMGSLGGVAKMMPGMGGIGADQMQAAERRLKKNEAMICSMTKKEKRNPALLITDTTARSRLRRIAKGSGNKFEDAARFISEFQRMRTMMSRMSKNMPAGQDPSMAGADDIETMMPGNRSARRAGKKKKKAARGFGGGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCG4</accession>
    <name>A0AAD2GCG4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCG4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="190" mass="21125" checksum="2185AE0F27B42131" modified="2024-05-29" version="1">MTISTIIERNNQTIAFFNESDYLNAIESSLTSLRETSEITDPESSEEESENESSGSSSDRLDQCMLLPAAASDIRRLLLHSDFIYDQAIPISQSLKVDKPILSAIVIFNAALAHHLAAESRDIPTPPKALFKAQRLYRLAYQAYTPGPGTQSILFQFAVINNLGVVERRLGNTALSNQYFDYLASLLEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDK7</accession>
    <name>A0AAD2GDK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002502">
        <property type="protein sequence ID" value="CAJ1970341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="2">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="225" mass="24209" checksum="31C3FEA68AC6FC76" modified="2024-05-29" version="1">MNGENSEDECCLCGRLWDASCTGWPLCDTANCPNVCCSTCSQALIVSDMFYCPICSGSGESAAATVGGAIATAVSVCSELESLPLSRNSIQGLLKNLLKQPDNPKYRKLRLNNKKVKELLDLDPCRRLLTMVGFTEQELDREPVLMLEGSVNVCEVRQLLDILEGLSDESETAATEPPIKTTLGIDSDQSKRPVDSIEGDTDGTKPLANKEAGPHASKKPKTGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JG78</accession>
    <name>A0AAD2JG78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JG78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="94506" checksum="1A7C49EB42250395" modified="2024-05-29" version="1">MPSGISGIVVKKNNKDLGISFLDHPSEDVVYIHNVKGKFRKYTILAPGLRVTHVNGFIVFTAAEARKLIQRTPIGGSVQVIATGKYIELKKQPKRSSIFRTSSSSSRLESASPSSSSSSAPLGIHLRPLPGRLNLVQITKVDNLLTEVPPGHILVAINKRPVRSVRKAHWYLKMLLSSSKRVVKIVTCPVHSFSTVSPGGVMAVVEPIMDHDSVNAFHPDMQLPEEDPFFAPLSSNWNKESSLEQQLCQLDTSFSSSNTNNNESEGVGQQPQYENDTILNQYEDDSLLRQYRVQRQDTGSTESSLIGREDTGGGAIGHALRKKSSILESIATDEHGDYIFEDEQDTNVIIRLPSSLQQSVRSMSTTNTTHQQFSTVSSEAASGLPDMILNLQTQNDLMDDTTMGSVPSRLQSSGGITAREQTSDSTNTTSSTRNNKDDPKVSVPFIFVDSASADSDEVFKQLQQQPTEVEDLQAFLTKEGHLQQPLPPQKNAAAPPAAATVAMKYIAAATKQKNATVQTPLRDSTNNEKKPSPYSPSFFDKQKTSALFQSVEKAKRRSGENNHPKKQDAGFNNKKNKLNRREIPALMDGDLVANNKKKRPTTTTNNNNNNSATTKRTTTNTSSSSFPKRTAKLVDDNVCLPVQIHINNMDNADLQSFLTEEEEEEKVEYDLLLKEIDTDLAAVAPPPPPNNNNNNRATTATPLTSNKSAKSFPFSLPTTTTTSPFQNKGNENMKQTKKNRLEPPHSWCIMSQPTHSFGVRQQSSVEEAKDHHDNEEEEEVVGDTEYYDEEEESLFAKGFHFLQAMAADATACVSPSSRYDYRNMKTKNRHHHNNNTTTTTTTTTTTRQFEVYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGC5</accession>
    <name>A0AAD2JGC5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001732">
        <property type="protein sequence ID" value="CAJ1947561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGC5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="474" mass="52172" checksum="77886E421571214F" modified="2024-05-29" version="1">MGIGRAALERELMRHFTFKRAIALEPAWPQNPGTTGQKWMPSKGPKAWHIWVAASDVDRVARALFAWLRPETKKCHMPFGARTHFVYDWGASTKGHLGDLAQPGGQWNGIIGKLINTHNTTSQTCTSLAPLFPIQGMLTKVFILKYCKQGKGKSLLQFLYAIQCIPAVKKPPPAHPEQSATLDADTPDSPLPPSMSSTPPDLPPTNPSVTAPTTAQPTLPASSTKRSSRKGSKNRRAKQPLEKPTETPQATPPTPLPRPTPALKSPPQAATDPSTGSSNRAKLSASEQPLVTEAFDRSAWLAAMDAELNQGPAGLFQMILPGSIDSFYVFVVRQKFASLAQEVLKNLAAFLISHLELWQDLKHQWKTCRTWLCLDHYNRTVTNAMTWDQSQHCAILEYERDVDLDQQVDKEYNEWVEKLLAAEQASLEFEGTITIDLSMPAAKDMDDGATVGSAANMAALLENMKTDVNNLCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH95</accession>
    <name>A0AAD2JH95_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12571</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001766">
        <property type="protein sequence ID" value="CAJ1950410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001766">
        <property type="protein sequence ID" value="CAJ1950412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH95"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="305" mass="33832" checksum="90C12C79A91A1F15" modified="2024-05-29" version="1">MVQIDPAAMTAFWEQEVQMRIVQDIRDQLELDGLTTFESFADYTKDDVSAMRKRISYIQNIPHFGQDSFKRLGQGRKAYFALIKTYLGDDKWLSEITKYDNMMRNAKWKGAGNLTVEAYIAVHRNAYQHLVSASEHVAYQLPNQQTRVKQLLDGILSSDARLNAAIAMVQASNVMIADFELASAHIQPHCPVAKRNLGGKRQSAEISALEVDTGDVDIASVGVGGGKGQRTGLHLRFHTLPEYQKLGNDERKELAEWRLTPAGKAAQAAGILLRDSKKQSGKGSPKKGKISYAKVSANVKVNVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHI3</accession>
    <name>A0AAD2JHI3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHI3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="97"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="337" mass="36965" checksum="323821D67F1B454F" modified="2024-05-29" version="1">MASKQPPGAETTADIRSKRSLKMPPDERKGNATPEQIITTDNQNNLSSSRNNSTNASKPTVVEVSGSPCSSRTNAVDNSTMNASKPTMVPVSGSPRDIICGRGLHIMNHHGNHNLHLIVDRYRQAYLTSTRKDKADITRSIVQHLKSTGARFLRRFNHDGDDKWVEVDERTAYKKVGHALRLRKKDHGQNFLKSVVHRQQLHSQHSLPLHSASHGETSISHQMAAMSGGSQKPMNPPSRLPPSSSLDMHLPLGPPANQLQVMTTQSASAPALGPQPHPMLHSSVIGGYGNVVIDPRLFSQVFATTLSLMTQHQQRASIHGSSADSRRSDVTPRDERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJL4</accession>
    <name>A0AAD2JJL4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001904">
        <property type="protein sequence ID" value="CAJ1956167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="376" mass="42719" checksum="98C22ABDF5D66675" modified="2024-05-29" version="1">MDWSLVVEGARPPLDRRPTAWNDTVDFMDIAVHVQASGFLDACTIHTLTVAHRHLAPHSMVLNTWIAPPCNPIKKRLYGFGQASKDRGWNHDVVNPRSMIHFARPYLSADDQLTAMQASLVWKKYAELRPFACVTSLKSLQLPRLLMADEKVPTTLDQHQAWLNSAALLRFDFNHGDFVRWLGGEYTNEGRDFNLEWDVIESHLKSKVLPSDLPPTKLDMAYCIQTEGVPLRGQCTTPMEATLLQNEYDNHPAVGSSLAAVEKKFAKEEWNSYHIHYLRFVYEFLPGLVINPIRCVFDKGKGRICIDCSNGPNSLGSINLYIPSPKDAIPGEEDECPAVYCQYAFDRFLHQVLRMRITRPNDPIMVHADDIEAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJU5</accession>
    <name>A0AAD2JJU5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="547" mass="61642" checksum="C325D3748535C273" modified="2024-05-29" version="1">MVIRSNNSDDDKRAATATATTTTTESSKVYSLTNGRCVLCMAFLGFLAIGGLMSSTRDLKQWASSYYTIDPPLPTNVTTKRDMKVPPRKPMSKLHQARAPPKPLQNDKSSRSASNQLHLIHHKELALHDYFSDSWLLPRKNFLDMQLDRIGIVEDACFEAIGKRNPRASSKMFVDWTHFLVEHLSKWWKVLHILDDPDGSLFQHTLQRLESYWHRAVTDAATSKRSPLHETIAMIAFAPYHGKAPGRAEYLTSLSLAATISSIYKVGFGRVVVTGMEDDDEDYVRQAFQLLHNKVHRHTAALNSTAANIGMTELTYVQMTNRSWTTTKWVELNIPRGSVHGMQLALSGQMVAEEQEQWLGSSGTDWKYVDLTEPDTLLHTKSWLLPMMKDGLDSGMSFFPHRLQPLPHELDFPIMANTSATATTKKQHYASFVNEGHYLPGHVQPFSNVTILDEDYSCCDGGGAWVGRMEPFCRGAKEPCGGSMWWSTSLNKPPKDTTDEGILEHYQKLVPYPMMRLGYGTRLVFASTNHGRRCFPSKTPCGNVTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKZ0</accession>
    <name>A0AAD2JKZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002042">
        <property type="protein sequence ID" value="CAJ1960049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="479"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1733" mass="194641" checksum="2012FC4DF711835F" modified="2024-05-29" version="1">MGWLEKESPEKQRAGVADYFAIVGVGEDLIWNHAQAKSTNDQNSARPEEDEAMLIERFYREIVDCRIVAVEASREAYKDNALSAIQGQFVLGVPSPSLSNVASRGGTDDGEVELGGWTVLKETKPMDVDAALETTSVICNSQSRKGEVYHANLDPVSGLAEELQSSLEARLQLEQDSRMSKSTPLKDFRRKVTSSFAQRLVLADTYQKKKFYLSYRRRAPDEFSEKAISQVQLLYARVHKVTLDATIDNRSATESAVTTSTVSQKGAAALLRVAEAGKNVMQSRILGSPQIMTRGSMDIGDLAAVALETLLELPAGFDAWSIPEPYQTINLPSRHESRANQRDHQSTVDTHFASEGSSNVENEQNRDCASDWQDIVRPRIVTKASEVDESYMYIPILAIRRQRVGEEERFNEDPAIVDICVSFWNRMGEPSLPVEKIDPFDDEEIKSILLRSTEWKAAALPVQSGVSSQYWRPPAFGTNCLLFKRNLPLGFCDATFKATVLDRFPYRNYKGLPLPEEELPMFCYPTGCHLYRTRFKDVPLPQYYGFVVKNERGDSICVSCVSFMEPLTKEKKRQLRQLSARRKRASLPHSIHVNEMASGSSSAAMRRDEFPDMLTAFDEMTTFENKTICLVSRYPYWTAFRKFLSHLHSISCSSSALPLERVPMALSSPPSKDLPLVDLSYERLISCLDIPTIVAIVLGFLALEKKIIVMSSQPSLVLDVCELLRSLLFPFDLCAPYVPRLTEPFMSCLDFPGAIFVGIHDDKKQSGLAAVVRRNMPEDSTIVDLDSGSIDCSGDRVKLLQSSWEIIPQGPRGSLVSEIETLCRDVGMVPGKTTTGSDAIVDVSSATAFVDDHNGFGSVNGEPLDDRAIRDAFLRFFCSIMGGYERYLVVPDADFLVSGEDWFDSKGFVSSVSEDKAPYLGLFVSTQLFQAYIQRRTEASDVHCLLFDECVVEYHSSISHSPYGRLGSEVETLQSHDDASPQLLYSLLVDQSASEARLPRPEIIGDTDSKHGSESDSSAQHSEKTNNGDFALNSTGDLVTVPSARDIPDASRFVYCIDGNTTFPDRLNADFYFPREPESWLVEMSTAPTPMLTRSEQEIEEADRRQKLAISSHGLQSQRRCLWQFPKLMGSHFLGAWLLCMPTFVAQNHISHQTQSKYLLYALGGLRLLRGKRRIVPDEAAYRALIVACGRTKSDRRMELVKIFGLLRSDGIFPSAVTLGQYTRALAEGYSKRSIGTTEESMIQIDDPITENVKSEKEAKTPKVLEPGLFLSSLDSNLNSLEEAGRRWRQNKYKDQDPVSSQFESALNDTSQSVLVDQIKRRSNKPWLPVSMSSSFLVDMRSPESVASCGRLEKESIRLVAIWSRTQACEACGYILFDEEIQAGWDAIQTNDTSGSVKCPRCRHLYMPMLGYKEFSIEEALTATEALKTPGDRDNKMKPLPPQMGSVFSHTDAAYVTYISPASMRLSLEKQIKENGEGILERDTLKRLDPQLYYNLWWYSARFSLPLPLPVSDSMSKHYCAFAAWDYNVAVRACHSCARVLYPFSTERQTHHELTIASAESLGDDPLLSKFNLQGYFSHVWDHEDLSGILVCLVEACDKRDFKPAIECLIGYNERRRKNLALHSTNKYGETKYFEGGTVVDQRDIEYDLYRTILYLAKYQCTTAFHVFFPATLKPCKGYHFWCPVAPIPIFDRLFRDGLERIRSSKQNAHHIANARDVSDVALAFRSVFGHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL41</accession>
    <name>A0AAD2JL41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002024">
        <property type="protein sequence ID" value="CAJ1959793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042012201" evidence="2">
        <location>
            <begin position="20"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="255" mass="28632" checksum="41545CE20DF30904" modified="2024-05-29" version="1" fragment="single">MQLVIAAWCFTFLSTNASTQRLNQFPNEAGSTTFSSRLSAKAKRNRKASNKSSSSSSSSNKKSKSGSTKLPRVIIFDLDGCLWRPELFELVTNADGPPFTHDPQDSSSTVVPAGTTLLSKQGQRIELLGSTRQILHELYTQEEWYLTRIGNSSQTDPPEWAYNLMEMFAIYEDNDDDDSNKNRMTKTPTATIPAVTCQMKDVFDPSLCILDKNADKATQFERLLEQANDQSTSNNHKRLQFKDMVFFDNEAGNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM16</accession>
    <name>A0AAD2JM16_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002108">
        <property type="protein sequence ID" value="CAJ1962507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="210" mass="22948" checksum="E8FC77724D39222F" modified="2024-05-29" version="1">MFVVRQKFASLAQEVLKNLAAFLISHLELWQDLKHQRKTCRTWLCLDHCNPTVTNAMTWDQSQHRAISEYERDVDLDQQVEKDDNEWIEKLLATEQASPEFEGTITIDLSMPAAKDMDDRATVGSAANMAALLKNMKADVNDVCTELETAAEELAQAKDAEAAKDARILELEAKMAEQASVTGKHRSSSPSSSKATSSADSGGAPPGGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMI6</accession>
    <name>A0AAD2JMI6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="323" mass="38117" checksum="4BB067966B187BE9" modified="2024-05-29" version="1">MSSRLIILPKKSYCPWSEENVQKVLRDEEKHAREVKASSANNNNDQTKTQNHNKHQDDDEKDDTKNLAPSGNFSLFAKEEKQAHIEQEKQIMSEKDTTRRRNHRHQPQHNYLRPFDRSTSAAMDSAVGLNSRKYKHSRKDAALKNRLDPMGGFCISDKEIKSDNKRVDVDDDHQPIDRKHSRSSERRRDRNQSHRRKSRRPSSSSSSEDSSSCSSSKKRRRNKRRREYSRSRESGSKSSSSSSTASHVDDSSQDRRKRRRKRRSTKPRSDRRRKKSRRANDGDGDDDARSKTMSKEEKAKRELLMRCAQREEEERWRQRNLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUY9</accession>
    <name>A0AAD2PUY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L18a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS14002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUY9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1953382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="183" mass="20991" checksum="C3B9E1AB52A383C0" modified="2024-05-29" version="1">MTVSGIMKQFQVVGRKAPTDAVPNPEAYRMIIFAPNAVIAKSKFWYYMHQFRKMKKTTGEILDVVEIVEKNNRIVKNYGIWLRYSSRSGTHNMYREFRDVSLTGAVSQLFDEMAGRHRTRPRSIQIIRTATVATKDLKRVNGMQFAKANVKFPLPHRVASAKRGQKALSSRTFTTVRPTTFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW07</accession>
    <name>A0AAD2PW07_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="147"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="378" mass="41598" checksum="0C4C8CFE62475437" modified="2024-05-29" version="1">MADSTMVSTASQAATERTPTDVELSGVSLPLIRSICYNQISMLMLSTAAIAGLSMLLSWNFEALDMSLLQWNGGQGLHSIFDLSPTPFQMIEGMVAVAPLIGLERLLEESDDQGAIQSGFATSNMVLSLFGRRRSVEDIEGTAPELMAVLALGIALCTGLSEELMFRSYAPSALFSLSNSIMISVLGQAIMFALVHVSPSANASQNRVMGGLQFTNGLWYGMFYQMTGGDILPCIIAHVVHDMYIFCSSWDTINNQMDYTEEAYKKSLPQSEESAMSKLQEMAGPVLNRETLNFARRFFYAFDSKQQGSLSLQDVQRAVDYAFLKEENPPKPQVVKEMFNTLLQARVTTELPSKRVGVSEFLCLLFALKSNTPIMTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWM6</accession>
    <name>A0AAD2PWM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cleft lip and palate transmembrane protein 1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS18984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042245383" description="Cleft lip and palate transmembrane protein 1-like protein" evidence="8">
        <location>
            <begin position="16"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1960989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="64710" checksum="A0DD7EEF6214CC5F" modified="2024-05-29" version="1">MLSLWIGLFVAYLSATWISLQQAVKPAVPCRPGSNQCFQPLLSPSEPMTLELRLYQPSDEEQDNSYRWRVVESCMLNFSLPSSNFNPIHLTKNETCEVPIPNFARFRSPDESQVRPLKARFILRLQNNYIAAAIPFDLTRINFRRDGTYSNKQAPRNLMEEPLAASNRTQKEKPVGDTWIPYLKYGRSPVRIRIVSDFREYGVLQRNDGAKLEAFNRTAYRPMVYVDDLALPHSSQNELGPPEANKPPVKLQIKIGAIPPMVDSLNQQFQVAFAGVESFLPGEDLDEIRYLLQDEKLYRFALTQVISYIHIWVDYLAFRDEIGFYRGKENMSGVSSSTVILRFICSFIILLYLLDGGSTSWVVLLSLISSCTIEAWKVWKLVNPQLSLKFPFLIFQPYQNAKAKETAEYDRMATKNLAMILYPLVIGWSIYALKHYQYKSWYSWLVSNLANAVYTFGFISLCPQLYVNYRLKSVAHLPWKVFMYKLFNTFVDDAFAWLIDMPWKHRIMTLRDDVVFIMFLVQVYLYKVDKSRVNEFGYAFEESKQEEPSNEQKKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXV6</accession>
    <name>A0AAD2PXV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002380">
        <property type="protein sequence ID" value="CAJ1968351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="188" mass="20680" checksum="EC37BEB29BE03069" modified="2024-05-29" version="1">MTKNATVPPASPLATFMKGLIDSKKFDSAEIVTDNPKRLSGSVVRRPHLHGKEESQRWESYDKIENECINCPQRRASIDDDDVFFSDFEGSSCSEGDDDDDDEADDTSSTPLPSAPLSPPFGNNEMDDVMLQNHNEKQSSSLSYQMALQMVQQKYAASSLSSPTQSPIQQSKNKLRSGIRGGESSVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAE1</accession>
    <name>A0AAD2CAE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1900549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000117">
        <property type="entry name" value="Probable papain cysteine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041946588" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="53"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1900549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="342" mass="37665" checksum="2165C0A1EEB52954" modified="2024-05-29" version="1">MSLKTVLLAGFALVSATIGENTFESELWDDSDVAEQTDHHSPLPTSYLSSEDIPEHFSWGDVHGRSYLTHSLNQHVPHYCGSCWAHAALSSLADRIKIDRNGAGPDINLSIQYILNCGSEAGSCHGGSMLTTYKFIKKNGFIPYQTCMPYLACSSESTYGFCPYVDTTCSPINTCRTCMHGTDECVALDAFPNATVAEYGVIENDVEAVKAEIFARGPVTAGLWGKSLSNFQGGSIFDNVDAPRNSTHAVSIVGWGLDENTNQRYWIVRNSWGEYWSELGFFKILMGMNVLGIESRITWAVPGEYTVVNPHPCFEGGENCKPINQRYQDPSVKVASILSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC16</accession>
    <name>A0AAD2CC16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS1361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000025">
        <property type="protein sequence ID" value="CAJ1927851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CC16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1927851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="401" mass="46102" checksum="906370D2CAA11E75" modified="2024-05-29" version="1">MSHKPNEGVKAAAVIFDSDLVKLLNSDDIRIPTNFVGVRRVRPHKLLEEKRNSNTVRNENTVFTVKVANGIGRRMTKQEKKKEKQKMKQKQKEDRKRHRQEQMDSPTSIPSNLKTPSIYSSTTNSRYFQVALNNTALEQELAELRGERNGLPPVLLSPAMAIHAETILWPSSGSGHIEHKLQFTYDHEMSKKWAELLKETMRPAEATREKDNKIRPMPYQLTPEPWTRLRQNMGQQKLESNRDAQHFSSRWDLMPSKCKSTRMICRQPTETDLIASLVFEYLFMESKYYVSCGAKFGCDFLIYDGPREERHAFAGLRILKAKEGQLPIQSAFSLSGFVRCLNTAGKFALLATVVRDEKCENPLYRLAFVDIALEKVLTAPTHKKRARTQKRRDVAKNLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDC0</accession>
    <name>A0AAD2CDC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS1832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000104">
        <property type="protein sequence ID" value="CAJ1930072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000054">
        <property type="entry name" value="Histidine--tRNA ligase chloroplastic/mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707:SF1">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="86"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1930072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="534" mass="59452" checksum="AAD8805CD8BDBF2D" modified="2024-05-29" version="1">MSSPFTAEHVAEWASFGTKLKGKPTPKQQLAAKERKAKCSEMKKRLVKELNDPNWTEKKIEKELDRLAEEGGKVAERPEYLDGPSGTRDFYPPEMKVQNWLFDKFRETAKSFGFQEYDAPVLEHVKLYERKAGEEIVDQMYNFTDKEGKHVTLRPEMTPTLARMVLNKTNLQTGEVRLTLPLKWFSIPQCWRFETTQRGRKREHYQWNMDIVGVDHVNAELELLAAACFFFKSLGIGPEAVGIKINSRAVLEVVLAKHNIKKGQKDEDGGDIFAKACVIIDKLDKIGGEAVTELLGGIGVNAESAADILQALQAPTVDALTDHIGAESESVEEVRRLFQLAEEYGISDYLVFDASVVRGLAYYTGIVWEAFDRRGELRAIMGGGRYDRLLELYGGEKCQIPCVGFGFGDCVIMELLKECNKLPEFQGSGVDYVVCAFSPDLYGSAAKISAQLRACGCSVDLMPSPKKNAKASFKHADQTGAKRMVFVAPDEISRSVVRVKDLRTKDKNGEAVQVDCPVDKLDTVDALVAEAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE14</accession>
    <name>A0AAD2CE14_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS2193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1931003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010487">
        <property type="term" value="F:thermospermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042009472" evidence="5">
        <location>
            <begin position="33"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="71"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="7">
        <location>
            <begin position="468"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1931003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1337" mass="151875" checksum="D68DF6B907769C2F" modified="2024-05-29" version="1">MLFSWNLQGTLVLIVWLISISTIHVCVDGAAADEQEETISSSSDDDDDSDLQNTVYSMIQWVINHGGYVSPKIELRAFSVEIDGFDSPSSDDDDDDNDEKYSFGVFIKSDERVKEGERLLDLPDDVMIYSDVKAVTVLDNMCLLADEVLLERNLNAEGKSEYGPYLDFFEKFVVGQINLPATWSQTGRYILGNITQATYFTTFRHYYGCFLQGESGEEIQRILNESGLEGFGDPDFWDENLEIALSRGRHDDLLVPLYDMIQHSNDPRKMNIVRKKSGSPNDHSFSVFASRDMGPSEELRYSYGLGSPQENHWLGFVDYGLGTMEMFRTHGFVEPYPQRWFFPEHALDFMIHQDGPDDDGTEAYQPKLRVQWLSDTIPDDDALYTLRVNYDGLFDIRNQMIDAYNSPKTNHNLLAHLTPHEISISFEFLLSYIAALDTALKAADAMNQRTGSEYIVTEEKVAIENMDHLYFQLYQCSTMITKILNHEFNAIDELQSAYQQINYYKDPKTNDRCLYLDSVYQQCISYWPHYHELVVHKSAKYLKEDLRRVLWVGGGDSGVLNEFLKYPTLELAVGLELDQQVTRSAFKHFASRPHYDDPRVQWWYGDASESLLMLPEHYFGSFDLVIVDLSDTVFSLSVSAELDVIEAISLLLRPGGIFEMNELFMKKVSKVFEYTVHYNFNDVPRILDQSAIFASNDVDFMSRELTEHELVEDATILVEKDSMLTKHRFDRIHDYRHNPNPAFKKLCKVTQEEEEEKPSEDQPQSAAPGIMMIVEAESLTADLSSLPAVRISVIKAIEGVGLTVVSEKESPLESPWFVIVMKEGYVVVRLWVEKKYCALDLHLWSSFDSHEGLKKAIVADALGGDLMNKSTSSYRIVAGGMFGLSNWKEEAKKHGPQIDNLCSEKEAPVLDQPSSADVYELALETSLDIIQGKELTVAVMCNVTSEPCQSLETLYDHRLVNHIIPLHPCTVDDVKFDGWTGNKEEYLDECTMQRVQQILQQELKENEFVDMLILDPGCSEEFSDSLRYLNNGTYINFDDIFVVGTVDSKNDVWKRKLVDYFRFGLAQVDPVHRAHLLFNSTSQKSSLELVMGVVGDPLFFEHMVDAVKRAHEIDGEDDPTADVTIEIRNVFGGYWRDDKIDDCDLVEFSQVTKAEDYDTTDAKSQWASQRPAGTQSVARFVNQDQLDPQVLLPLEDPQKLINVVRNALAPKGAIFEAFQFKSINGGDGVVCTGSWGQGTAVISWDGRSQVDINLWISNKSTMMENDEETCSSPDASPESVTDQELKDIKMLEVLIVANTASTLKPSLRDVQPRGYGRIINSQKDLDSVDTFFNQHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CER1</accession>
    <name>A0AAD2CER1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000091">
        <property type="protein sequence ID" value="CAJ1929630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CER1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF508">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041904763" description="Mitochondrial fission process protein 1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22338" checksum="4B16B269292AD95D" modified="2024-05-29" version="1">MWKSVSEGSKLCFLLAICSAPTTLLHPQHSCPYNRKASHYEEDKSDFLDDAGKRQYQMLVGMVQWAVTIGQMDIAYAVSLLSRFSSAPRKGHLELAFYLFGYLKKFPNKQLPVDSRPPELCPTLTATKGAFKADFLEEYPDAKEDQDCREPKAFGKPVQTSVFFDANLAHNLVTRLSITGLLVYVGSALVSWTPKHMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEX1</accession>
    <name>A0AAD2CEX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1916293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1916293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="120" mass="13360" checksum="73B09D366D117AC2" modified="2024-05-29" version="1">MYFPDDAVIDFSQYAKRLLKSLTSNADTNVTVIFDTKVTEVVDNKPSDGAVILESGETLNAKDVVVTGALGFAVTLIKPCYSYLAHVHVDNPKYDNVQELANFFTWGYSHDWCFTRTNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFT0</accession>
    <name>A0AAD2CFT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Palmitoyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1889044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1889044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21424" checksum="50A0422FD555E8B4" modified="2024-05-29" version="1">MEIIEEAPSAASSPPKSPRRNPQAPPSSSRRKQFAVSTKWESEAAANGGTIKDFHRFFCCCAERLGNMFVFCKRPDGSPIVIAGPCWPFCCFVTVPMILGACGSVSYWLIIRENSALPLWVSYIYFPVLGCVLAALFCVSCTDPGLMERVTDEEAGEGGWFWNEQVGSYRPPGALYCRECGVLIQDYDHLCVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGC8</accession>
    <name>A0AAD2CGC8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000069">
        <property type="protein sequence ID" value="CAJ1928977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGC8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="175" mass="19095" checksum="463F8BCF08C56DA7" modified="2024-05-29" version="1">MFWWLIDFARHPSGKWRFKRIDEVATDFDLLVVDPEGKTVVLSRLQLDKCEQNLGVQMSPKLNPKAQHDVLVASAKSWANQIASGHLLPYDVFPLLKTTILKTLGYPMALTRLSTAQWGKDLCPRSVGFPSQGQGLSQLSLGPGVWSHGVPGPLYQSSCGSPIDQPTGDAALSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGH1</accession>
    <name>A0AAD2CGH1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000078">
        <property type="protein sequence ID" value="CAJ1929315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="723" mass="82705" checksum="BDC52D72F72F2675" modified="2024-05-29" version="1">MSPRLDDVYADENHRVEESSSSSPLQETYSRSRISAILAQCDVVKRSSAAYLSTTDSSSASSGDSAVSCGGAESAQHESPESPPYLFADHCRNLYLKTENTDDHQYWYCDWTNYFVPFNHTNFRNEFKSFPKLENVVKDYCQPFRTHAELQNMYVGLDTESMPRVTVTEGGKDGPEPYAVRTTMIHLRPDAKQNLILQAVHQAFMALHPTYYHIIKSTMHEFQALGGHGTVSLVLVANVVTHKTSLERHLLLRFYHAEQLGEYLTESQLDDDLEIELDLNKGRAEEKKKIKNIVINSREDQPMSPLKSQHTRLNELISEASALVKLVQRHGFLPSHQAPGPTQEETSRILQSKHGQSFTSKSVLSVFYKDVRNLFPSLSTKDKQVLQESHSLMERIWSELEMVKATHNTLITESSSRFGMRPCQPNLDRDFCFHLAQISQHNMLADLAQQMEKAETILHEALMEYADFEAYLKQVMLNDYLIRLNNSKHKDKNKFNPDHSLDMGQAPIHMKKRKMEEFPWDDEVRRALDKVAHQVAANCLEAFRPKESLQMSIDATHRVFVAFGKADDQDQSQFLKKLSRRNMIKVTQQQARVKLLLEKIILLPHSHPHIPRVKQLSNHWYELTLQSKTSNIRRGPIPILNFQTKFGGQGCITSHQLILVKGVFRTEVLVWDWMDIDLAHTPDHPFAKVVVLENGKRISGFNPLGVDPAKIVKMAQTLKGLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH47</accession>
    <name>A0AAD2CH47_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000347">
        <property type="protein sequence ID" value="CAJ1934630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH47"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042128788" evidence="2">
        <location>
            <begin position="17"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="288" mass="30319" checksum="068640235042D8AE" modified="2024-05-29" version="1">MIKTFALLLALNSVNAAANKCACEAQKHNFTIDCGGGSASNNNTTDDVAAAAAAAASMTTVTDALTYLQTNGCSSDCISELCEKNFFIVQSHYDHCLDDDIPSEIGADLMQNFQAQCFSCAIVRQEIDGALQCPTLDLDCTDGTGSAAYDRLVSKGCNELFQCTSANCKDDWLLLQVVRAMCGIDSLSVAAQRGYHSLEEPCKAFQCNLSLDVITKTLECSVEDLLSDGDFDHDHNDHDHDEDDGDGGNKSGPSMAPTGGNVPATDSGAAKFALGTIVAIVVAAVALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH58</accession>
    <name>A0AAD2CH58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RelA/SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000225">
        <property type="protein sequence ID" value="CAJ1932944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="579"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="789"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="873"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1932944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="977" mass="110498" checksum="D21282E007540EA2" modified="2024-05-29" version="1">MSNDVDPKQTAATLQMAAYMESTGDYKNALDFYRKALSMLFQTVGQKHPTVAETYEKVATILEKVGNKEGEKTARKKASDIYQELFTVLFKQGKTDEAYQMYNKSKGINLEPSLLKRSSLTSSRTIFSSASSRSSELRAETISFLDTLRGYLDCRQQMDAKYQEVDEDNRLANFKLKTDSGGIQLPDKEDQYKEVYQQQSVHGVAVKTIDELYAAAEVAQPIYEKTIKRLISKVCDDCGTSLNKVGMRFADLKQQERALEKAEDDYGRRRPGPAVSWLYDIVRGSVEFRSAKEIERFVHNLRKKKTIHIVKAKNRFERPSLTGYRDMCIHIQLDTKKGFHHICEVQLHHKEMIELEKEIGSHEFYEFFRSYFAGATGSLRERLDDLQLISEGRFVDDSFLANLLAECRDVDRLERLGKLFAKQLCEYDNAIQIYQRIAQLESSRLGSKHPMMAGIYSTIADILQEKGSMNEALVMYEESIQLFASSIGVTHPAIAAMYNNCAGVLEQVDRYDEAYEMYKKASTIFQERLGEKHPSLARIYHNMSGILQDQGKIDAAMDLLQKSLNIKLEAFDDTHESVANSYDSIGHVLVRQDKLEEATEHYEKALEIFRRTVGPAHSFVATVSHNKGELLHRQGKLDEALEMFNTALQIKTKNYGEESSAVAGTYDSKASTLVDNNMHDDAIDLCNRALAIKKNTVGENHSSIAHIYITLGNILLSQGKFEGAMDMQSKAFRIVTKVFGNEHYSIVDIYSNMVMILIERENLEEAISKAQQGLSLATKLFGGDNTETASAQSNLGDVQRSQGKAQSAMEAYEEAMRIDKRVFGDNHIRVSIGYRKIANALVDLGDKKRAIKNFNRSLDWHETRSGDYAYSHVDVLYDIGRLHVHLKKFDKAMDYFQRAFDICVEAECEDHYIAAKVLAGIAWAQKSEGADLDKSMNSYRTAEDILKATIGDDHIVLGIVYNGIGEVLACQGQFETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHX8</accession>
    <name>A0AAD2CHX8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000179">
        <property type="protein sequence ID" value="CAJ1931736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHX8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="613" mass="68086" checksum="1020854019D12BB9" modified="2024-05-29" version="1">MKDSITNPPEKDPNSIMTVADQGQGGLEEKTRSNSTTQSSIALTKDNPAITTSQRRSKRYPSKTAEDGAMKGRSLFPSDVAQGQDGSMAKARSNSTTPSSTDFTEDNPDTMLSKSQRKQTPPSKTAEDGAVQGRPLVAYTKKLRVSKFHRLYKKAWRQEVFGNQAFITWSSRTAEHFGHAISKCPGWWAEASTDQADAHSYDEIAALILSGLKVYDPSLGGSMPQLRSSMQNLFSLGDLEDADNDKASWSLREYFLRLATQCPTVVFDLAAAQRVIKTDEKLPRFWEFALVFDPTLIVQRAEPLTWMWLAASEFFAHPWTGPAILPPIVEEFERLERESKISKAQSKSKKRPASTPENPKVILSDAVHVIASTPTGTQEASAPTDAVVEASKPCVRTSEEHGAEDHNSAPTYRDAAASPPASTVPLTTDERLTRLLAVTWNASPFRHITIFNVSIVFDWQGVGLSEFNQVQTAYNAFHQFASGIWGEITSTVVLLPFADGRFTRQQLWIRNLKEFDEKAKDWAHLKIYLDPNFGNPYILNKPGKTGSKTYKTRMRFGMDTAPPILMQELRSVLSSEPRAGVFPTPIQVSITPEIGRRRRTNWSLANSAHSSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI93</accession>
    <name>A0AAD2CI93_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000435">
        <property type="protein sequence ID" value="CAJ1935006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31610:SF0">
        <property type="entry name" value="SLC26A_SULP TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31610">
        <property type="entry name" value="SLR0360 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="612" mass="66288" checksum="AFC18B62218E18BA" modified="2024-05-29" version="1">MSESEEQAPRSSGNCLKTFCSGLTMTGGDMGSLSQLFFDNLSTLLGALFAIQDLTNFGPNAVSKGVMDEYVWGRIVPGVGITLLIGNIYYSWQAVRLTNKYGRPYTAQPYGLNTPAAFAFVFNIIYAVFFAEGGGDAGFIKGYKVALVANFITGLISILFGCFGPLILKVVPPAALLVPIAGIGFAFLGIEQVSYSIAAPIVGYSAIMWVFLGWYAGVRIGVGKYRIPEALQVILVGVILGWATGLNDPEDTKQAAELVKWWGPVWSAGDMFGDFGMVKDYLGIVIPIGISAAATTLMCLVSAKEAGDPFPVRETMIIDGIGTCIASFFGSPFGTVVYIGHPAHKASGAKVGYSLVNGIIYFIMSFFGILALIQSLVNQATIGPIVLFVGLMVNQEALDFIPSRHYPAYVIGLFPSVYDWVTNVSGRAPLTDDGTFNTNTPGGAGWIGVLGWKRGALLVSMLWVAMLVNVIDRQWKVATIWALITAMFALFGIIHVPEAGFDNFDDAFWEQCTSNGCWEFGYQWMYFVSYIILTATFALVGFASKLDSTIEDPIDDETRHAFDDWFSEASMDTTVHRKKDMKDLPPGVEKVASDEPDEKLPSDTENGDEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIB4</accession>
    <name>A0AAD2CIB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000402">
        <property type="protein sequence ID" value="CAJ1934866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23669">
        <property type="entry name" value="GH55_SacteLam55A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059186">
        <property type="entry name" value="SACTE_4363"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="677" mass="74960" checksum="ACD550197AF62A0E" modified="2024-05-29" version="1">MAAKLSFPQLRDLFPDKNSVLIYPDDFLDDDDDDENNNNHGNDDKTILLEDLVDRHSGHFSDRRIVVLFRPGVYNNINFPVGYWTQVMGLGETPMDVEFRGSLGVYCLPANTDNPDVGSLDTFWRSAENFTSNTSFLRGPQGQPSVPIVSEGNDIQKSLRPPFKAFYPLPSLDGDSSPQEGMLWAVSQAAPLRRIRVKHNLHLSLGNNCASGGFMSNVDVGQTVLFGSQQQFCARNCAFETKTGGAWSMVLMGCTSDTGRHGDWVGRRPQIIDEPHPSDGVVIEKPFLFLDESSKLHLGIPRARSGTNGTNHEAMSSMERVMVDNLKFVRVFTQYDDVAVIQEATNAGIHIVLCPGIYNWQKSLVISRHHQVVLGLGMATIQAPGDGSPCIMVQSGLHGVRLSGVALEASVISKFIFEGSTLLQWGTPDDVGRAPTKESNAQPSAIHDLYCFVGGRRSERTVKVQCMVKIYSSNVIGDNLWLWRADHCVLMQKEAPNKPELSEYHVTTEGECQCETGLEVYGDNVTIYGLAAEHTTGDIVSWHGRHGRVYFYQSELPYDVIGANYSDDVCGYRVHIGADHHIAKGVGVYSYFRDCPNVEVKSAVSHHALFGSYSNVFTVWLNGFSGLKSVINGKGSVTSTPGNPHFVEQYEGENIWSGRLWSGLWKKVTKEIWKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIG9</accession>
    <name>A0AAD2CIG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Patatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS3567</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000324">
        <property type="protein sequence ID" value="CAJ1934035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="507"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="625"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="13">
        <location>
            <begin position="1002"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="9">
        <location>
            <begin position="1154"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="1035"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1934035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1308" mass="147046" checksum="4A86370A9021E79F" modified="2024-05-29" version="1">MAWFVRASEDEGPTITTTTRASHSHKASLPPVQPLPKPSKLLQFLEDKPRVAQAVQRWVIDTDGYKGPIASPPVNADDPSNGAPPPPPIDTSNYASWHFRSLFVVEATLLNTSILFFFLFFWLINRNTHLRPTKGSTIVRKHQTAALEDDDSLLDSEESFDDICDNDKEDHHIEKKDEANKDVHKVPTRESITRLASPKFLRKEGKGRSSKRVSTMQRLVAYGIEQADDDDGWESATEAEDLDDEVDKLEWGNALKDLLRITRTLGYLNEKALTMCAKSATYETYQKGDEIFNADTFDGTQYGLVSGKVELIFHDFEMHDDFLESIDESNDEKMSYKNNSNEETEVRQPFKLILGPDKQITSSLALFWGMISNMKDDAARLNGDSPTKKRKCPLRMSLKVVSDDAKVIRITPDCLSRVLQEHPEDIFRISGTVLNRLQRITVQTLVKTLGLRGDLLSPARPIQQYEKDMVNGTEWKQFDQEMKKTGFCEGKELLHRAIQLFQVRLGINSEIDAKSRKLLSDNAELILFEGEKTLIEAASKHESCYLLLTGNMEIGIYNPTGRNRSTFHRHQLLYPGALLGEHECFTGEFSLTAVKSVVSTDSANCMLLRVPRSVYNKLIIRYPKALARALDSLLHQISSAVYLLQATSDWLTVTAATNVARRGTPCDSLYMVLNGRLRSRQKDSVDKNAPFEYGRGKMVGEIGLLANSSWQSDLYAIRHSEIAKVPIETLLSIVHKFPKAGLNFARAVALQVQEQSRRRASNHAAVAAGGGGIPRSITNSTTNLGGDAMPSYGLNLATIAVVPMDSTAINLNKFCSTLTKGFQKIAPSRLVTKESIRKDLGDKGIRYRNSALNELRMVRSLAEMEENHRLVIYQADPKYTWWTRLCIQQADCILLVVSSDRAPEGERIEQSLAWAFESMDVRIDLVVVGQDHKVEQDDSDDEDDEDFDLKDDEEMNVSDQLNNWSEKRKWISGHHLVRAPIGRHKLDFHRLCRRVTGRAVGLVLGSGGARGLAHLGVMRALKEAGVTIDLVGGTSQGAFVGALYARQPDDLVGVESECRKMAAEMSSMRSKLLDLTLPMTSIFSGYMFNRGIRKRLGNLRVQDLVLNFFCVSVDLQKQKEVVHRKGLLWKYVRASMSLTGYLPPVAEDGQLLVDGAYMNSVPVDVMKHQMGARVVIAIDTHGESERDHYMWGNSLNGWWVLWNSLNPFSETVRIPSMGDISILLQWVSSDQHRRNNRLLSDLYLVPPVGEYGTLEYEKMDIIVEKSYNYAKPIVDEWVKKNPWLISNGKLAPKATTFTSTVPTLVKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIT1</accession>
    <name>A0AAD2CIT1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS2004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIT1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="40"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1930621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="25218" checksum="B6464C44846E0721" modified="2024-05-29" version="1">MVRGIEGVTLDADGNAVKEWDPFLPRPPSMRDVEADRSTSEQVAVFGANTKEGTTLVRMMSEKGLRVVAAVRVIRSNKTKQLIGLPGVTVKQADANDRASLLAALKGCTRAFAVTRYWGKFDGAIEQTMANNILDACASVNPPVKNMVLATFEDLAALESRGRKSQIVPTKDGRIFPDFSGKSKVDTVAKKKGVNITHMMTSFKDEEGNKKSLILLRGMNKRIVVNSHINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ96</accession>
    <name>A0AAD2CJ96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS4838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000491">
        <property type="protein sequence ID" value="CAJ1935628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1935628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="611" mass="69637" checksum="E188D04A6C7C3961" modified="2024-05-29" version="1">MTEELQSRSSTPPFQLNIHEWIESQQSAHGVRHDDYAQYHGYCTRRLSRLSHHPDVKKHLVCSSKFASDKSAAKGRGRHAYCSRQNDTFANNEETGKVEVPHSSILWYLVVLAERSWAHANMLQKQKKQRQNVLRKLKKATLWAKKLEEIAKDCTDSLTQQECQAYASWMVANLALEKMDYQMASQEYANAMSKCHALSKQVPQLVEERRGGEAETQKAAKLLERQDLFVNRADTLLRPLFRYSQYELKQAGLPTMDEPQLDITAVSNNAKKSAEDIAIEFRGQDLVLDSKDLRVLLLKLQSMQQEKAASESEEEKVAESNEGSFLEILSVLDDALDVVQNVLSSFEQANSGPAVQAKRTQYLQWKGYLQYEKTRRVMNHTELLLKDITGHAERVHVYDALLQHSQSLLNLPRPQADGNFAAEEEEDEFSLQVQANVLRLRALKSYHMAWYYYEKPRKYDHAFALIQQSSKLMRRAQEEIAACDEDMPRSDEYLQELDDLPFHSTIATIQAAMYLQQTRSRGKSGAAIETDRPLLLRLNENDSGTVLAALTPIPIPCKLGFFDLAYTYAMDSTDCIDEVQKYLDIHTVEDNDDNEDSPSASSGGWLGWLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLJ9</accession>
    <name>A0AAD2CLJ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6173</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6174</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6175</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000735">
        <property type="protein sequence ID" value="CAJ1938546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000735">
        <property type="protein sequence ID" value="CAJ1938548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000735">
        <property type="protein sequence ID" value="CAJ1938550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000735">
        <property type="protein sequence ID" value="CAJ1938552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1938552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="245" mass="27719" checksum="843AF69D2C7AB9E4" modified="2024-05-29" version="1">MSYGDASFLGGGAYSDELLFWFRTVWSPDIVAGIKLKASNPNYVHINSLEFLVAFLQEVATVVRFEGTSHAHPQIPKRIFPIPNISHFTLDEKLRLFPAESRTLLRPALLSILQSKAGATDDPRKSGTLRSRRLHFLKFCYDMKLRDDYLMNGPDFLHERRVATFALYTVALATGRTIKGQYIKSATIKQYLHAAASFICLFTGRDPRYNNPSDTKMSPDIHATIAEVERHENVPNKLEPYTVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLZ7</accession>
    <name>A0AAD2CLZ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS6388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1188"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1230"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1939027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1426" mass="158218" checksum="1AC77B148F0F7C7E" modified="2024-05-29" version="1">MKASGEDFDPQEEFYDVLQQEMTQIESLMDMEDDDALFDLLDEMHDRNEEELEDWNEVSLARSTEVDVSAQSYELTDMLDEDYGAIAKANERNQNEEDKKTGLEKKKKREQGHKAREKANAKAKAAHEARKAKEKKELEVGERRENEVQKEHERKEREAFEKRKTQLIEAKENFEKDKEKKMDIPGKASTGDCLASYSGQPPAFEDADLDDDVESGSVSIDTDSSDDSKYSSDHSDYRNNNGAVGTPLAVSLQDDSDSEDSNSAPPTAQNDSRVRMQSSSAGRLSTMRANAQTSHGLSPADEEIATRFRNMLTTGMSIGAVSQQMTTEGVALHIQDSVVANNGEVPRPPGISAPPAGGMASAPGGGKIVGCTMTPKGTTFGVVRKKQDANLGTQFNNAGIVMTPEEVASMRKKRGECFVCGQKCFKKKVFKMIPLNIPGKVQKGKCLVCNPKDKGAAPGTSPIMARFKTGRGRKAPQRTKSGGEFAGDGDEPVPGSRISASSPSTGHDFTMHSARRATLSGPVTGQSLPVLGSRLSTFRPSTGYNFNFRPTRGPPRPGPAREQGLAGSPSLSTPERSPGRDFGLDNFLDSKESADADDDGDAAISGAVVVSEPLIEETEEEEESTPPTEYGEENAKAGGKKVLDEKKSDGDEEIRARKKKKKKEDGDKPELGGFFDNSAGALEAVSQGILAESAAQITQDSVASGLQLDDLFSRHGTPMYGGASRIPMPPQQIAELRKKRGECVSCGQKCVDIKVFKKIPLDIPGKVHNGKCLQCKPSEFQEPARQHATTIRQEDNYMDTSTESSTVIPDEIAIILEAATTEATTKSKLRPETLQFLDTIHGYLVCRGKMDAKHAEVDEFNIIANHPLQVDPEKIRVSANDPFSYKAQYQQQSTQGHSIKSLKELYDAANATVPIYRMTIDDVISKLLAKHGKDHVDFTLKLCDLKSKVRAQEKAKDDYAKRNPKPAFSWLYDIVRGSVEFGSALHVTEFLDILQEERSIEIVKAKNRFKKPSLTGYRDLNIQFQIDTGKGFKHVCEVQIHHKAIKKLDEELRSHDYYQFFRSYFAGATSSLEERLELLKRISSRGAIDDLFLRDMLTTSKDVERLERLGVLFRDQLCEYQWAFCVYARLFEIHKEKHGTKHPSVASTYSGMALVLKEAGKLDEAMVLYKESLTIFKSAFHEQHSTIANTLFNMALILKEQGELSEAMSLFEQSLKIDKKNLGEDNAAVANTYNELATVYRKQSKLEDAMLLFQKSLDIKRDVLGSEDGSISDTLQNIAVVLKNQGKLDESVDLFQQSIDIAIKSMGANHSSVAVGYRKMALVLEKLGKADLALEFYDRSLAIYVKNVGEKHLSVARLYSDMAYTFKAQGDRGQSKRYLLKSVNIKRRVFAERSVESGLRKKLVMMKRMPEQRHLSPLNIEKKQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM35</accession>
    <name>A0AAD2CM35_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000014">
        <property type="protein sequence ID" value="CAJ1927195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM35"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1927195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="132" mass="14853" checksum="CBF0003B9FF72EF0" modified="2024-05-29" version="1">MPTLSARPKQGIETPFRSTCDSYFSERALALAPMRNVTQEFDTRAMICMSTSAMLDIPALTCPDGASSNSDEEDETIPTFSLLRRKRQRDEKDTVATSITMASRRSFKKLQEDCSFSLHMLSPIDKTVFKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMV4</accession>
    <name>A0AAD2CMV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMV4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042038971" description="NAD-dependent epimerase/dehydratase domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1940146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="412" mass="45818" checksum="53C9C1347699C0EB" modified="2024-05-29" version="1">MMKFQLVVSAASLIVGSTAFVAPNTASQRSSTTHLDMSAALIVQNKGGGHGELGYQLAKALTDHEKITSITILQDDACNDEKEPFKSYSSDLPDVKVVKAPLSSGDSMTSADVKSLLGDATFEYIWDNCSKGAEGSGKAICDCAKDWGVKLLTYVSSAGMYQPDDDTTFPMPETTPIKETSGQAQYDAYAVELGLPLVSFRPQYIYGEKSNKHDYIDWYFHRLVRELPLPIPENGTQKVSLTNSKDVARLLIAPLDNEEAAVEQRFFNCGNDKLYSYDEVAYMCAEAAGIAKENVMIEHYDSELYGKAYFPFRLTNFYVAPDMAKEKLGYTGSQCDLAEDLKWYYQGFNDRGGIDEKIPLIKDAEITVLSITRFEVGSIYDKWDPIPMDWSEVQELGIEAGWMEEEDDISIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP44</accession>
    <name>A0AAD2CP44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053135">
        <property type="entry name" value="AKR2_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43312">
        <property type="entry name" value="D-THREO-ALDOSE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43312:SF2">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="150"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="629" mass="70548" checksum="0BB377C55D412AE2" modified="2024-05-29" version="1">MGSVASKVVFGLDVTKNIGAYMIYGWSKVAYQGDVKTIADEKKEGPTFLDNEALVKALSSKAFEQSKLDLLTDDALAKIGRQLEYFYDKEKASEAEIVEIAKGLIDQSIWYLPLVSDKIGTDKDRKALQKSKCPKVRFGKTELQISLITCGGMRLQNTWIPDNVPLLSPSRNFVLKSPPQENIKKCIKHCLSLGINHFETARMYGTSEYQMTEAIHELMQEGFCKREDVIFQTKLVPMLTKDFQKIWDTTWKNVGEKLGYIDLLGVHAAAENNEKLKDTMAFLLEKKKEGKIKHIGFSTHGTSEMIMELINTEQFDYINIHEHFFGSYHGSGTSNTLGGQGNLACVKRALELDMGLFLISPVDKGGKLYRPSQDVVKSCGKELTPIAFALLYCWKTNGFHTASIGVARPSDLDEVVEAARMMAHGTADKQFEAATKRLKDRAVEKLGAEWVEKGLLNLPSMMEESTDGIAVGHILWLYNLLVSYGMYEFCLDRYTSLVCAPWNKKKSFQENADAMSRGNLGRAYDPDVDLSKALEKHYNPELALERIKQVHEWLKDDQNPMSDEELDKLGWQKGYDLTVWEPMAGDIDSRAIPKVLLQNMTGGRMGIVETGPGQSIKQEATQIRTALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRM4</accession>
    <name>A0AAD2CRM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000736">
        <property type="protein sequence ID" value="CAJ1938591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="47953" checksum="718C8BBC11757004" modified="2024-05-29" version="1">MPPLPKFVASTASDPKYLKHKRRYCRIEGCARIVKSQGLCQRHGAKPRKCKVDGCEKQAQGNFDRMCKSHFKAMKRMTTPLPKVDNTEAPPPPHGCSVYDDVLPSSICYIPSLETVMPLIRHLKAGFDELKPSAWHRNEERRARGMFPVDNPATQLEGWERELVWMEILVLTGAPKASFRHLARAWGRDKGFHMVLAQFICERHGDVRRKRRQGEKEEDGEKKSGMKTRITGKNKLSSGMISADIWDDSCYGDADTNEALAADIFNFSAQEFENVSSKWKGAYKDLSSGSSLGAPSMASLPHTSLLVERGKEPAPVATTPSRNFSHPLEMAGAVASQYLLRYQQQAIPNLTAQSIQEYPEIQHARSGQQYRQQQIQDIVEQQSSSGGDMQSAPVKPSDTGHGDAIAAMSQPSTFQQVSQIASLERPEDPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSE3</accession>
    <name>A0AAD2CSE3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001313">
        <property type="protein sequence ID" value="CAJ1945032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSE3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041913946" evidence="1">
        <location>
            <begin position="25"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="463" mass="50381" checksum="F51E1A5A3E338157" modified="2024-05-29" version="1">MKISNSAALVLASSASLASHCAFAFTANKNAIHPTLPTLPTSSSALQMAKEAGAIDDGKAKIDDLQLKRMNYQFNRGVGGTSDSNTPHVNPLSDIQSYVPVAGPVLTRKNIQDSTCIVSGSRVTPELFYLLNHEDSAFGFNKIVSLSQDVSKTKKRLLTRTARYTGLLSKLAYEEGTVVPPSSVLEEATNWIALVDTPDELKTLISSASQVQNLSVLFFYAPEAESQLESLSSELMTANPSASLVLVPQASVEEDPNEDPLEADFKPTPIMYYYEQGKGEALIPEEEKVTKTPKAAVEEEEKKASVVMEPKLVHDAEFTFDEANRLAIECLQLQAGAGKTLKVQCMEKKSMLVMMQLVRQESPATQNLFTKLVLGLREAGYERPQEIAYMLDKGVDHMKEAITNFGVANPGAVKAMKSTGSASTADGDAIQTTNAWWEDPEFQKLVKESSLKTGELEAETTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTQ7</accession>
    <name>A0AAD2CTQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001491">
        <property type="protein sequence ID" value="CAJ1945754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="64"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="435" mass="50112" checksum="BF2718A581C24AE0" modified="2024-05-29" version="1">MMSMDIPNAFIQTLMPDLGDGEDRVIMKVTGLMVQYMIDLDPTYRDYVVYENGKRVIYVVILCAIYGMLQASLLWYRNLRASLEEYGFVFNRYDPCIANRMVDDKQLTIRFHVDDVLASHMEQQVLEDFFTGVNEKYGGLEEVTCTRGKVHTYLGMTLDFSKKGKMKIRMEDYVDRMLSEFPVKFKENEVQETPAGNNLLEKGKGAPLEKERHEVFHSFVAKLLFLSKRARLDISPTVSILASRVQSPNLSDWHKLVRLMRYIHSTKGWHLTLSADDLRVIKWYVDASFAVHPDFKSHTGAVMTMGTGAVQAITQKQKLNCDSSTHAELIGVHDAMSNILWTRLFMEEQGYPIEKNILYQDNKSSILLETNGRSSAGKRSRALNIRYFFVTDQVELGNITIEHMPTDEMWADYMTKPLQGEKFRKFRAVIQGDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU07</accession>
    <name>A0AAD2CU07_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF22">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="646" mass="69583" checksum="C241A2BFFBAD7D94" modified="2024-05-29" version="1">MARLNKNRKRSRKGHHEPRLFATFAVVITGFLFASFGGDCSCNTVVSAFQPTLLARRRNLSFSSDVTRLSSPTRRPLKKITSPDLSHTSSRKNDVRSATLNANSQPESDTEDDEAVKESTPMLLSKDDDNGLDDNWNIPSLAMLTLPILSGIFPFLLQTAKSLPPNSTEQWAVIGSLFVGNRVYLYALSGTIVALAGLRGATDSSFLGQRIVDLTEELLYRPSLESKTANLETVDAQSLEPNRMEDVVADKTAEEKPAMIEALRQSGVDTSLDQLTGETQALLLPVLITLSLATSVILLPLWTGGDGDLSDENSLDLFSGFLKEQEELLSKIIPKLSELWNFGLLTLFTRSEVRRLIYEILSNGTLSEKYSNEMTVADVNGKGEDDAGLEPLVIIEWASAISIALAAFLWKAWPAQNFVNMALAILVARAIQLDRLTVVLGALSLLTIYDATSVFLVPAATATDLVTSIDLSNTMDATSSLVASTVATSLATDSSNLLVSSPNAAGSAMGSVAVQKLTSTSFQPGLLTIRIGNDNRLGGSLGLGDAVFPSLLAMLTRRFDLEQVKQDILKDEEKVKGASLFAASLGGYFLGCFACEFAPMISTSGIPALVFIVPSMIVSVFLVATLSGQLEGFLEFAPNMDIQSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVU8</accession>
    <name>A0AAD2CVU8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVU8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="294" mass="33230" checksum="E42923CB86850B30" modified="2024-05-29" version="1">MMVLAHPPHAVPPHSSWGGGPHQQLETSMEEDELQDICDHVQLHSSQMIPTVEARPNVPKEVQSPPPPSSVQEQEDQERQEQEQVSSPQDNENGADDDDDDDDDDDDTPLSEDQARFCAVKREAILLLSGAHKSCSGAERIKAMTLLGALYKAETKHDLAVLGEKIQELLQQKREQDEETLRQKQEEANNRTPERFSRIRSGLTRMMQPNSSDVASVASQPCPRRNARQDNNNNGRGWRFFWQRGDANEGRRRQRHSHDGIHGLQVATASANAGRNARMQSLSERRKIWDTRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYW2</accession>
    <name>A0AAD2CYW2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="627"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="67345" checksum="EDF2D77FE0A41790" modified="2024-05-29" version="1">MAFSFGGSSTPAPAPSGGGFSFGGGSTPAPGTPGPAPGGFSFGGGGTPAPGLFGSNPAPAPGGFGTPAPGGGGSLFGNNPAPAPGNSLFGNNPASAPGNSLFGNNPAPASGNSLFGNNPAPAPGNSLFGNNPAPAPGNSLFGNNPAPAPGNSLFGNNPAPAPGNSLFGNNPAPAPGNSLFGNNPAPAPGGFGQPGGYGAPAAPQAALAGHLPYANLNPDQKRAIDTLYQAMMQHKRTILQVSTMAPKLLRPNTSQSSTSQADAAAGQDSLPLASNVRKLRGQVQNLQHQLVHIRQRVEHTQTLFQSATTQSIMFAKWPTEAVAMRRGVTLSKPKSASSSQDAELQGKLKDLLDREAAHVDRVERMPSPYLWQTLDQLEKRIALLQQEMTTTHKALQEATTTQNQDVDVVAIIKLQEQSIWKLAAALAPIHQKVDQLRFSYQRQETKENVLVEADQKEKQRQQELDHEMRRQMVKALPQKAAPGPGPASGGMFGSTPSSGTGMFGAPAPSSGGLFGAPAPSSGLFGSTPAPSGGLFGAPAPTPGGGLFGSNPAPAPGGFGAPAPSTGGLFGSTPAPTPGGGLFGSNPAPAPGGFGAPAPAPGGGGLFGSTPAPAPGGFGTPAPGGFGAAPAPTFGGAFGAPAPAAGAPPAFGGFSSTPSASTSTPRSRNKKSGGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCA4</accession>
    <name>A0AAD2FCA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS2143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00913">
        <property type="entry name" value="PCD_DCoH_subfamily_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1930901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="135" mass="15224" checksum="E57F6EF3249F6314" modified="2024-05-29" version="1">MQVCSRDALSQKKCGPCSGQVAALDIATTKAQLAELQEGWYLTHNDQRIRKDWKVRNFKVGMAFLQQVGDIAEEEGHHPDFHLEGYQYVAIEIWTHSIGGLSENDFILAAKIDQVPVELSKKQPKRKVEESINSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDZ5</accession>
    <name>A0AAD2FDZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000169">
        <property type="protein sequence ID" value="CAJ1931654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="449" mass="49650" checksum="7549E265E42C018A" modified="2024-05-29" version="1">MDSLLERIEDNKLDALYLFINETLRQQDEFDRFMESLQTVLPLNWSIQRVEIGHQFLSMVQEQGKLFSLVASLEGLRTLIISDGYVPRKDRGSIDTEIFFDKMIQARNLQILDLQRLQLTSIEQVEILEDFLKLQESLEELRLTGLYVSPDITLDPAIEACCEMPNLRSLSLSAAKKGDSICAPQRDIPMIEDGLQELLQGSTTIQDLSLRSMHLKDEQCFIIAESLSGNSFLTSLDLRQNDEITTTGFAAILGALERNYSLWCSVLVDHDTYQAKFNSLIELNAANRGDLIRSPTKQKLIAFLDALKDDPTALFYFFTIHESILRPTVKFLLYKYILLEQKKEVAPAKVAVAAAAAATTTVAAAAAAAASIPTTATSISVDTTTTTTPRKRALEELLIQKVVQEGNYETSFSSDAAATQASVKKTKILTPTTEDGAPQSSSSSSSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEX7</accession>
    <name>A0AAD2FEX7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS28</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1889238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEX7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1889238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="105" mass="12127" checksum="BF0BDD93D5B19EB7" modified="2024-05-29" version="1">MSQSQNDAGNMKDLGRDGRLSFRNFAEHQLRKEFKADAMQKCDMQISAFASCAKDEGVMVVFRCNEFKRAVNECMAVYNSPERFEVYKREHMGDLENKVPGQIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG74</accession>
    <name>A0AAD2FG74_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS1369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000025">
        <property type="protein sequence ID" value="CAJ1927903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG74"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="111"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1927903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="720" mass="78349" checksum="6E9618B5D9F546CB" modified="2024-05-29" version="1">MSGIAFVPLQILLVFIDILLSIVTLKWVGVIRKLLASDPVRSVPLKDDPSHRVHADFKEARVSVPSNGARTMYDVANKAFLDHSDKICMRQREFLGWKSPKVKEFSSKVLEWTFADVEKKAHSFGAALRANGCVPSEPSTNLDKVKKPCRMAIFENTCPEWMMSCVGAFSQSVGVVTVYATLGIDSVIEAVVDNIVPVIVCNKTNVNFLAENAARMPSLKAIVYTNDLIPKDDETEILEAPRGLKIFSFEDFIRTGDVVQYPVSPPVPETTAVVMYTSGSTGKPKGVVITHASVTGGAAASEFALGLTPSHRYLGYLPLAHIMELMVEFVCLGNGTSINYADPKSLTQTGSYPIGALEQYGPTHMVAVPKIWDTIKKGLLAKVGQSSPVAQVLVHTAIQWRTFAIKLGLDTPLFNALVFKKFKKAVGGHLEWALSGGGPLNGEVQEFIRVAFNVPLIQGYGLTETCAGLSIADTDDGRPGVAGVPIATVEVKLESTPDVCDRGGLPYMSTDRKDVEGNPVWGRGEILVKGSNVTSGYYMMADKTKEVFSDDGWFATGDIGQFLSDGSIRIVDRKKNLVKLKSGEYVALEKMEMVYGNSSFVDAIAGGICCYADGDMDRPVALFQLSEPVTMKWAKENGVSGDFETVKNSKDLYNAIMASFIGEHAKSDLSHIEKLKAATILTDPWTPENGCLTAANKLQRRVVIDSFPKEFETVKKKGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI23</accession>
    <name>A0AAD2FI23_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI23"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042143163" description="S1 motif domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="620"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="688" mass="76719" checksum="4640DF33B90E2E84" modified="2024-05-29" version="1">MRNYISFFAIFIVAEISQQSLSFVHSPSLVRNTALLGVNKNLPHPEYTIDDESDTTESTTPVDKGEYFSVTQTKEESKEEPEVSKGGPPIQKPEYGALSQGTVMKIQVGDIALARKAWKKRRRSGSPLLVPCSVLNVDRQSMVRWNMIYLLEKFGLSKKDGIEISASDMANRYRTFLKSSLQNQADALSYSSNNEMIKDLFNKKTQESYGVRLVEKDDQLFLKAPISKSKAHQRTAKTPVLQFRLPKKGDHGDEDTMTHTGYLRARKEDKEYGFLPLSAALRVSQKDDVDSGRVEEGSIHPAVVFDYDAMGDGGSPLLTLSLNPRGTRDNLKMKTDRRFMPIEDPKCMFNELKVGQGPYQAKVVQMLPGRALVDMQVGREVSQAGMVNVLGTLQFKDSFESDPSVAKKSKWLIKDFDDNDDDDDYEDDSESVIAASLEDLDFDEEEDFDEEDEAGIAEQLLALRDSSTFEEGTFEEGEEEEDISNNFEVNDDGSILFTDPDTGKPILLNEDDGEEAPKGFGSKMVKEKPSKNRKFKIMNHQAAEEPKTRIVSKHLKVGDVVDVYVRTVSKQSGQFAVTTNPAVQGRKAKDMKKENDASKRLKKLKKSLGGGLRLIYESEGSECEGTVKAASKTGDWVYVEPDIEGLPVGIAAMSEELSGVNSGDRVRVRIEGVDEERGQLSLQVLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI78</accession>
    <name>A0AAD2FI78_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000292">
        <property type="protein sequence ID" value="CAJ1933703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="887" mass="100452" checksum="A108B07A12DCCA3C" modified="2024-05-29" version="1" fragment="single">NHHEEIGVSDGANNPGGPAMDRHYVSGTSSVPSKGRCFPRDVVFAPLSYQGLGLPHPFGCQVFKHLEMLLRHMANRTKTGDYMEANIQAHQLETGTSFGLLQQVYTNTAILASDTWLKRVWQELEGLDIYIACDSPALSLRCTDDSLLMDLFINLEVKQEELLWLNWCRMFLQVCTVSDIVTADGRFIRRSAWNGFRDECCRSPYQWPRTVRPTKQHWDLWQTTLSRALLASNGPHYPLQQPLGPWTDRLEDWNWLLSPTTGLFHCHGATWKHFCSEGSHTTSRRYAPGPSLPSCPWWTAPLPADVLRATVHSITGSDRVLLTGTGRAFEPSSSSSPSILHAWQSAAELCTDYYGWVPDEIEVHGDEATLADALLHGRLRVISDGSFKNELGTAAVQILVKHGGCHRIIIRCQTPGLPQDQSPYRSELIGLLAGIMAVDWLLEQWFPNILIGPKVRIACDGLSTIEMTFEDRPLSPTDAQFDLVSSIREAILRSSVDWAPQHVYGHLNKSNLFDELSWWEKRNLEVDGMAVEYRKELETANHLIAPNPRFFTELAAMYVADTKQSCLDPQFIQECVTLPALRSRWRDKGTISAEAESEIAWDTLGRAMRSLPAGLQRWSTKHCVGMCGTGKFKVLWGLETSAACPRCGDFEDHLHVPRCRAASATAEWDRRTAAFSAWLDLQLTGPSIKLAILQLLQGVRTPPSFPPRTISPLVRPAFLAQQVIGSQGLLEGRIASSWLPLQQQYYDKIRCRRSVSLWASRLSQQLISIGFYMWEQRNSVQHLDDNIQLHECHSTVNEGIHSQLDMGLDDLPKEIQPMLTCRRRVLRKSLVDKEEWLKLLCQEHRDFRRSMKAQRRSLDPDQLFAGPYMPRIHPATSREKSLPLWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIH9</accession>
    <name>A0AAD2FIH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1941365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="504" mass="60035" checksum="0FF8FE3FDFB1137D" modified="2024-05-29" version="1">MSSLGFLDDLYEQLQRDPDTDEDSDEDSDDYGHSMDYRGKRPKAYTNHRGYGISYQNNSYRDLGYTDRYGDYHWDSDAADSDAEDDYLDRDVQFYRPDGSYEGKAPRWCLDNGFFRVAPGVWSGRWYWEHFPEELENREKDRATRHLAKEKRRQEKEAWERRDFENERRDLDGLLPPRLHKCLLKGCNEHFPSIEERDHHVRSHPGNGHARYREQHNIYPTIEELMGFMPPTSTRGNDAFRSGFDFLDNLGVQPPISTRGKDSYQSADDALLDQLKHDLRVMGVRCDLDSDDYDHGGDDYDYRDKFGARRAWDNWHDDVEEEDDIDFYRPDGTYECKSPQWCRDHGFFQVGETEWSGKWYYEQFPERKEQWEKERVEIQREKEKWAVEMEAAEERALEYERREIEELLALERDGRDMDDFLMPRRSDCNHLCLLQGCSEQFYSIEERDYHVRFHQGKGHERYREQYGICQTTNGPIFVPNPSSPPPVQCKQTDIRSFFAPATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FII1</accession>
    <name>A0AAD2FII1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hexosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FII1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="42161" checksum="7D6FF9B6B38FDE26" modified="2024-05-29" version="1">MALIGKRRRWLSLAHAPIRRKACVTVTLALAVALGWLLRYGSTSSLSPSEMSIVIVTKPSSSDANTNKSISSSHQSGAIVLLAPQRNQGSLWATDRFCLLLPRDYELDPLGKDAAYTPEDRTLLQKWAPQSGLIFVEIDMYSKDALEPNTTVDQIVNWRAGNDGGVKGRDLGYQSMCRLWSGRLQHMSFLDDFDYYLRMDDDSLFLSNFQWDPFVRMKAEGLTYAYRRTAYDSWGIDELWSVSRPHLDLERHHLPFAFRRAGDKSYSYFGEQPYNNFHISDLKFWRSPQWSGMMREMDEHHLFFKYRVGDANVHAISIMMMEESSVAVWPETPYAHNSNDYHNDWGQQNWQDECDAAIRDDKQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ56</accession>
    <name>A0AAD2FJ56_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ56"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="200" mass="22608" checksum="A4708F44474CDD3C" modified="2024-05-29" version="1">MSIYSRIFANTSKRFASAAISGRKVPPHGVWGIPGAVVFTWIIWGALNDDIKQSVGLYWDPDTEVKRVEAEREKRLAAKEALKAAKNPAAEEEEEEEEDEGVTAEDIEEAVNAAIEQSGGAEEEEEEEEEPAPEPEAEEEEEEEEEEEEKPKKKKVDPATLTKEERWEYFTDRAINPGDDDDDDDDDDDDDDDDDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ85</accession>
    <name>A0AAD2FJ85_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ85"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="780" mass="87257" checksum="52DC7EE9204D3D75" modified="2024-05-29" version="1">MNLRTITTSAADVALALELIMPFGHGNRIPAQYIVDRSREIESETQLPVQSQLKVPPPIKGISDHNDDIVNEEIVVQLPVETTPMVVEETLIDDAPDDETDTNEVCTEAKQDLIEAEESPISNSDKSSFTTEEITPMAVEETPVVAVVEDASPDETDTSAASTETTQDLSDTEDSRSSVSINHKALSIESSDEPKTSTTVHADVRHTEDEVETQSAADEDDISIAESLDFTISVSMTDDEDDGSVEESGSDHLNTVQEDSVSIEVIPKMSVTENRKETGEVEQSEDKYAKSLIVNDSGTSLDEDTRSVSPSRVKPHIIDIPVEDGEEEYFQSTTSRDSFLIKLSLLGALNDVIYDDFVEQVCEYKALVMTLVKRYEVGLLREVEKPETKYFLKEYKAPVPKTVHQESEKQEWYRPEAKSVSLQQRKQMLQLEPLQLPDFSYMDELVKQSKAQIRASANAAKREIVQEDKTEEIADDVVISIVEEYEPIEPELGQLSFEMRDEDLEVREDAESREVEEIIDLDVESRNVEEVIDLVEPEMLEGPDHQNNVEPAVLEKFGQQNYTEPAVLEESQQQNVDEQNVDEPTTIEGSVQQTPKFRAVIEIVDDIENDSSTQEHLVSDPLPEKEIPSASSEENRENGEVRESARGPTLRSSAFTAFTVPKPEVTRRTGNRRPFASTTTMATIRAEVEAKYSKMARPTAPFDRNTLYFQSTTTPTRSSMPARSMPSTSPKPVTVTGAYKAPVVRVATAYAAMRRHQRVMPEWEMPEIINLVDVPEPMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLF5</accession>
    <name>A0AAD2FLF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000924">
        <property type="protein sequence ID" value="CAJ1940641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179:SF12">
        <property type="entry name" value="GALACTOFURANOSYLTRANSFERASE GLFT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179">
        <property type="entry name" value="RHAMNOSYLTRANSFERASE WBBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="4">
        <location>
            <begin position="630"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1940641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1033" mass="118470" checksum="CC7A94476E374597" modified="2024-05-29" version="1">MTGVADLYLYLKKPHSKDRWYRLSSHFVNSTGHTKFAVLSWKRTGSNLLCGILHNHPDITMHNELFNTIDIFTYHPSFKTIQNCEALWTPQTRDLDPVGFLRFVWSGMLADGETPIKPGFKAVGFKSFPEHWITPRNEDVWQQEILEDLRVKKIILWRQDELAVFISMKRAEKTNAYMTHQYPSDLTIHVDPAEFQRFLNNYNNTFQNKYRSPISKRDTFIIEYEQLVDPIAFEEIAPKLWRFLGVQDDAKIQTLKETVRQSKPNENLSLVISNYEELEFCFRHSKVKHFVEKKEKGKLMHPPKVLPLNDHVKTDELCWSLISPLSGAWKSLRAERSRQSGVSIPPDLQSWSLLVPICSRAKSGLTSGDIETIKQRFNFNSNRFLDLALSSQHIPNAYIDRESCWQMLENFAKSLKATSSSAELKLTECIVGIDEDDILYSNKAAKIRIRKMFPCAVHFVSIKPAMYGHVCKIWNHLGRQAKHDYIVLLGDDIRLLDQGWQQRIVRRFYEVSENEDLPLGAACVAMKDLAFPGFPTFPVVHRWHVGKFGSIIPQQFANQGGDPYLYELYSRYNASSFEVTCRLENTIGGDGDARYLKHQINWRAHVLTENLKHLRESLGNLRPRGICLDVVVPSYRTNNNEFLKRILLLRATVMLYVRFWIVVDNPLPEHIESVKNLANGINETSLKKDCNYFVNVIHYAENRGASYARNMGYNFTTADWVLFLDDDVIPEPNILDAYAGAIKRYPEGKVFVGLTNLPEACNLWTQMLCTCNVGYFYGIAKETVRPSWGVTANLMVRGARCNHTIQFKQIFPKTGGGEDIDFVYQYKKWHHDWKTPITVGVPEAVVSHPWWNSGQTCYSQIMGWAWGDSICITEWPEKTFLVFPNWIELIVCLLPIISVCSGQYAAGIHAALGVFVLEHLLKGWKYFDDAKSVCEETSLRTCLVALGAGSVLSSQEVTRTIALIRRQSFFSFSRRVDWFDGSKPNIQLDIQLGSIVRFGLFVAVIWSTFRNSSMLSETEPDVGIALGRLAQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM09</accession>
    <name>A0AAD2FM09_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001202">
        <property type="protein sequence ID" value="CAJ1944108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM09"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="187" mass="20679" checksum="AE25E57A05E99980" modified="2024-05-29" version="1">MSLWAASAPTNVCLTLQCLGCTKTFVARRDLTSGTIISSGLINHIKQSQSKKIRRTGINRRCLDIYQAQDLVDWPDIDISTSLGTVLDSQPGDHDHFPEGREEEVLSDVSMEDDNNMSLELDYSPIISDMTLKPSNSLPKNTYFSHYPVEANFSKESPLSNAEFNQQTSPSTKLLPPISQSENGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMS2</accession>
    <name>A0AAD2FMS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001709">
        <property type="protein sequence ID" value="CAJ1946511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMS2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="167"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="337" mass="38809" checksum="3AD7BB920898FD16" modified="2024-05-29" version="1">MMLGIEVTPEQVLIYRFEIIEDSPTTITDDDFKEHNIGVFKAHFGQCPSTLCIIWQDILNCTNKDLGLCPSDRSKEGLKRLLVAIHSLASVTGISTRRDQDDNLWHWMKVLWALEAKVISWSQKEYKQKNYGPGRKFILTVEGADLKILYWPEKEYNHSGRTILLTVDGVDFRTFERSTDDYNVDKKQYSHKFHHGALKYEIGADAFLPKIVWIHGPWRAGMHDRAIFAEGGGLREKIPEGKVIICNRVYKDKKHKDNDELMLPCVGDSSRLFTFKSCLRSRHESLNGRLKDYSILLDTYQHDPDNHVYAFEAVAVLVQYAMDHGHPIFEANTVPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP00</accession>
    <name>A0AAD2FP00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="507" mass="57546" checksum="471EB7F054BBF763" modified="2024-05-29" version="1">MKSFRKERSISAGPAIRARERNTAPVLSARERMETYNQSYDRPTDPTRSKRNPRTAISQPLRTYSKHAPLSRSATLVTHHQSNAESKPSLNVSKSYRAGKSNRRLEFQQSQVQHEHAQSTRKFTRSSRDFQKRSSRDSIQRQKSSSEGSTLSSRQVSMGDETCSDAHSRLSKYKTTMGSSYRSDPSYLVPLLAAQAYHIPGNTWFQDWRQFMRNNHPLFGICLHHKLHPIKSCTRMIALFGSILFGLVMTNIFYLFYLWNPDFDQIVMSITLDSGDIYTLTTGMLLLWTVGGGIHASFNLCLWYIAACSCCRAGGCCEARACCPSFGKHVIRGVVLMIVIMTILVILMRIAIGNPETDTLDDVATTSNVTDSNAIDFFFTEEAWDLNVNGTEEFHFVLAYLVQMGLSIFVYYPFFATVLMSGVLGCNGKVPLLGGRPYEVAQYKRKQQRVSKLGNSTYLDSYYGESSDEFALNFTFVSDDRESAHEDDIEIVWTPKAKREFERRWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ54</accession>
    <name>A0AAD2FQ54_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001756">
        <property type="protein sequence ID" value="CAJ1948796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ54"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="146" mass="16558" checksum="5B306F746DA70977" modified="2024-05-29" version="1">MKGRSLFPSAVPQVQDVTVNTRPNPTTPLSIELTKDIPPDPTTSKSQRKHPPPSKTAEDGAVQGRSLVAYITNLKVSTFHRLYKKAWRQEMFALATAQRVITTDEKSPRFWEFSLVFDPTLIVQPNKGDRAIEYEIDHAVVHVYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ86</accession>
    <name>A0AAD2FQ86_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ86"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042229567" evidence="1">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="170" mass="18172" checksum="C820E4EF69A5A3AC" modified="2024-05-29" version="1">MHFIHLTIVLMALLASPVVAKDKTKKKHKEPVRVALLMPEDLRNVVTIETSHNAGSEDHGDDTRLGHYGHPPDDCEKDERAVQINGIPGAICTAKCTDFLPCPKDVPKGVTAEPTCALQDSAGNHYCVLLCKPGKNKDANLRRAGDGDAGECGDATCQPAQGLGICTYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQZ3</accession>
    <name>A0AAD2FQZ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQZ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="459" mass="52344" checksum="9A303A7A99391C7D" modified="2024-05-29" version="1">MDRGSLRNLPRRDYAEIPVANDRAIGGGDQDGPAPGGGENGGPGSLTPGQATRGTLQYAGNKQHYYLFRSATRRLDEETLFDCTSDNFYQFMKNLGERADEFGWSTRGGILHVPKADGTMVNLLTEYGSITLEEIEIHERSYWNNGYRKSQDDRMLYECIMKSLSTLGKAKVNIHSSDYKLMSGQYNRYPSGLCLLKVVVRESYLDSNATTGMLRQRLATLDLYLPTVNNDIIKFNMHVKMLLEGLQARGEQTLDLLTNLFRGYMVCSDKEFVKYITDLETDHDMENRPITAAKLMKLAEKKYKIMVSLEKWEAPTQVDEQIMALQAKISDMKQKLETKKKRKKDDDDRKPAPRKKNQKQERPDWFNHAPPHDKINETKHWNKIDWHWCCEATGGHCGGVWRAHKPKDCKPFKKKNKFDPKKRSSGGAAPKIELKTAVDEEYLAGLTGGYESDVYSTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRI5</accession>
    <name>A0AAD2FRI5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1510" mass="167005" checksum="EE9B48BC1E559EEB" modified="2024-05-29" version="1">MANTEGMSDEFVASLMTTPVSKPTSASKGGKKITEKDSSMSGSGVPDIMERPQKASVNRRRRKGAPIMSAVTNQRLQERMEMPMPEGGQPSAQVIRSSQSSNTAVKTGQEPKRISTSQISERQQVNSRIGGPTTPETPGVLPPSIVGDVVEHSVSPMERKTTRFQRKQNQSRFSQQAKASQFQQQQHQEGQSNNAGPLLPNAGFPSVHMPIGTFVKKPKQSQRSTTKGKKPTRKPIVAEKPPSEQDSMQQASARDATNMLAQMSMEDIQSHQRDLEAALSPDIKAFLKARSQQKNKKKQQQDQTEEPVVGVEEDATPEPTESETPIMEKKKTEKNPQQEKERLAKLMSSVRTHHDLDQAYHQEMQQAHPLEHEPLLDAGEQGTTDASTLPNDNSRNDPVDKDFDMACDLLRSTVKRQTLWAARLVSQSLSERVRELQQEKLGHTSSKTSTTKKNWPLLLPISLRCLMDEPIHGQGILHTYVLQALYSLLVLNAVDDHLVWVDSSTRTGRTMEGGDNKNNQNGELPTIATDLSSSRWSEKDMYQHFFMEDAIPTPPLDTAYPSNTVQPLAVDTGKSSSSVAAYSTSSSSTSAMEDAKAFEKDPMWTLLSKMRIIPRLSQLLCPKNDALMLPEEAWIASCGILAMLGQRSPGAATVIVHQKSMFEQILDRCLMRYSLERQQPGHQLEEIALLEQVAFASIQLLLTLARQSRVTAKAMAPHMEEVLPALLLPSDGLSPLELRLQKMGIILWRTLMRYGLGLPGFATMLKMAAHHWALPHTNPSSLSAEYLSAFTQILECARVAQSKTSALDKAKTKPIIDEESMRILSMVPTHLAATQRQLLLPSAPASDSDPSSLTTQSVDACREFQWKAARLRFLSSYWSLAANTSQSTANQEVKVEEIAMEDELAFLENLDLWTDPGGVLEVAWKLVWQQESEDYEDLAIGTPKEAAASAFLSSFANTLVEMDMSRTSQKNRMVQQLTKAVVKHFVERIIEGCKRTRILSGNEKGDLSTWALPRQGWMNQCYFAVAKLLFHAYSIGVLTSSSDINQARMLVFFLLANLERGQEAVAAVLFSQDVLFMPSGNPLHDSSSGSSPISTLFLGEICGSEMARKQLDHSFKLQHGFGLTVEGYGPFALDSLLSATDRMGPKTNGELILPLGNLWLLQTLSGSIQMKQQTVDKGTNEAVRVVSTALGLLLELEEAEEIDATCRWYSPSIPVGAKMYYLLNVCLHPETILRDERIAEASGALFEKYCSQLNETSLFELSQACLHHTEPAKKEVADPEVDQDTEEKEKALLDKLLNSNMTTDTLSPEAMRSLEALLEDVIAAFRDYGAQYSFFTKCVRLFLSPVYPPSIRCRTMQELRGMLHLLTLPDDSKSDEELLEVFLSGGLPAADGSTKDASSVLDALAVAVAKESSDRNLDGFFLHFVVATLGRNLASSISDEIGSLSMMRRLNRIPSRISSLVCDFVLMILKEKGSKKEMAVAAVKACADGKADDNFVLESRIASIREGLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRM3</accession>
    <name>A0AAD2FRM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="105"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="286" mass="33651" checksum="8E39AEDDCE9899CE" modified="2024-05-29" version="1">MLDLITLEKELGPGPMRFAPKEERSFQAQMESLSPTEKQCFHNLKEKWNKHIEENKEKEKTPTHSYSDEMILRFARCSPGRNKFEETASWKVMKKFDPRFLTLTAEEIEKQLLSKTLFPVPGLKTNEGHDIFYMYPARYFPKETTTEEIIDNLGYCMNTMCEMEKASSEGIGFMAYMNDWKMSNFSIDYCYQFMMMLQGRVPVRVRMFLIVNPPSWFGMIWKIMKPMLSPDFRKKVHVIKESKIGDFLMEGYETYLPDETATGKADTESMVEDFVTYRKAAEKQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRQ9</accession>
    <name>A0AAD2FRQ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001776">
        <property type="protein sequence ID" value="CAJ1951018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRQ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="240" mass="27795" checksum="A34E84648C12EB07" modified="2024-05-29" version="1">MGQPGNICLLRAPPPRHVATHQRLHILPAHGGPHRFPLMFFALRFAPSRLDLQLTGPSIKTAILQLLHGVRTPTSSPLRTISPSVRPVFLAQQVIGSQGLLEGRIASSWLPLQQQHYDKIRCRQSVSLWASRLSQQLISIGFYMWEQWNSVQHSDDNVQLRERHSTVNEGIHSQFDMGPDDLPREIQPMLTSRRRRRVLRKSLVDKEEWLKLLCQERRDYRRSMKAQRRSLWTIFSPGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT57</accession>
    <name>A0AAD2FT57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS13636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001808">
        <property type="protein sequence ID" value="CAJ1952614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT57"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="111"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1952614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="468" mass="53275" checksum="0055B399E38A74C3" modified="2024-05-29" version="1">MQFDFNSDYPGLNATTVSQALPLEALSHDPIPFPDAQEISCARITTRVFNPTHSAVTTVQNVLVRTGARSLRDDASVSSNMSSDSSSSDESMKVEDQPIRHSAVTSVKNAYWLQRTIREAIYGRVLLAVVLKRRPPELSAADGAEWEVTADHCAVKEMSWQHIRREKDRLAEDPIKEVSSMQYLKLFFAEYQRASGRTVTQLDSTVMESFQVMRETNVMMPLDLLTDELNMYSIMPYCDGGELFERLDLNERFSEDEARYWMDQVLNGLETLQHAGICHRDMSLENLLVHQNGALIIDMGMCLMIPFQDTATQTAMAAFNNMSSNRSNLFHVANKQFLTGRSRPRLLIRPQGTCGKWMYMSPEIYKNSEPFDGFAVDMWAAGVILFLMLTGFPPWERACATDERFHYMTAGYLVQMLTEWNIGLSGDAMDLLQRMLFLDPKDRLSLDQVKAHPWMTNGQRSQPQGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTG2</accession>
    <name>A0AAD2FTG2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001811">
        <property type="protein sequence ID" value="CAJ1952647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTG2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="241" mass="26968" checksum="8953CDC711E9806E" modified="2024-05-29" version="1">MAAEEDTSVSSGHRSNVQVGREVAQMHSQAHRSDPLLRNYADSGDVIYLDSSDGDPPSDYADHDPKWKDVGNDGPSLDTGSTFHLRKDFENAEEETVRDLTLMFNYGTNLGSGRTLTQEVQAKHMEDQMCKFDPEAICDVDSASLLVKQGYRIVMDTDKDNAFIVSKDGRQWVYREKNGLYTYVPGKSEPMAQIPEENQTLTFGPKPETHCGVCMELGPRGEACLECARWGSFVKDESYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTY1</accession>
    <name>A0AAD2FTY1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001820">
        <property type="protein sequence ID" value="CAJ1953149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="472" mass="53503" checksum="D9023770F9A51E79" modified="2024-05-29" version="1">MEIKNAKFLTCIDTTVLYRSCIPLQNLKTDPVFKALDKIFRRYNKAGFQVKVIKCDRAFIPLTDDMLDDMGVTIDPTAAGDHEPTAERNNRTLKERVRVALARLPYKVVPKVITECLGRRAAELLNVFPQKDSISSHFSLQQLIDNVNINYKSDMVAELGQYVHAIKTDSSNSMKSQSIEAIYIEPTKGQCTGHRVLNLNTKKMISRPKVVVLPVTNQVIQRVEAWAAAKGVTSMKFFDKKRDLETFQDGDQITGVDDTEQGYLEEAFDQDYERDFNLCGQFDDINDSKREELLADADNDVDDMPELTVRFQGDDDYESDDDSGDDLCGQFDDINDSEREELLEDADNDVDDMPELTVRFRGDDDYESDDDWGDEGNEEEEPIVANFDHHQENVDRGTDDIGSLVTDLEDLQEPPEEEIVFEPEEPQVAKVTRSGQTYAQAAMSGLYLSQVPKKPREWPSSRSGSSDNKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUG1</accession>
    <name>A0AAD2FUG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS14328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1953725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="49172" checksum="030A0E728EA3B25B" modified="2024-05-29" version="1">MNAGRRMILKQSRILRLSTGPKFGSSALRFPIRSHSSSMPKDDSELKGSGSENGTTIREGRVRLRLPKDDSELKRSESANGKTMKEGRDEIRVPRENSAAVHHTDEESQHQRVWLPSSADEPLFWNEDVVKRNTQDPHNLSRLLDRIEKQELEGGRYRMKQYGVLHEDPAEDMRLLSENYTIPALASALRDREDVLQYCAQLADEGDFEKLQDHLHNFHPSVVLNRRNERRVLDVRKPLNAASLETIRKALMRMPRRVTQAHSKRAGVVIAICHVDGVPSIILERRAETLRAHPDEVCSVADKTIVETCLREMKEEIGGLNFDYHGDDGGYGISVLGVLRCNWGEVHHMVGVAVTPVVCFLGQDLAEIDLKPNPDEVSEVFTVPLASVMDKSQWLYKDDHAPIFVGGPYLIFGLTGYIMDRFFKDILLPNNVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV94</accession>
    <name>A0AAD2FV94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4116 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025197">
        <property type="entry name" value="DUF4116"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13475">
        <property type="entry name" value="DUF4116"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4116" evidence="2">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4116" evidence="2">
        <location>
            <begin position="250"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4116" evidence="2">
        <location>
            <begin position="444"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4116" evidence="2">
        <location>
            <begin position="549"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="709" mass="80667" checksum="3913124AAE9BF55D" modified="2024-05-29" version="1">MMDDIPLSSSPSLGDEVKNNEIRCRRILACKQQIKHWQDKMRSLEKEQEKYIKLARLRLDAPSTWRLLSRRERREKDFILAALESPELPEALEDFENGTFPSHIRLDRDILIARVSRQDFAKSVNGDSDLFVPPKLRNDKALVLEIVKHCPNAIEFVSNELKDDGDILRAILNRSKLPAHFLQHFSETLRSDADVMLEVLSHPNNGLSSMAYCSSVLRNDKSFFLSAVAFGNHQADGQVLRFASQRLKDDPEVVLHCVRQSGMNLKHASYDLRRDQEIVSEASKQDPASFRYCLPGIVKQTLLEHSEFAKKVVQHLPLSGVKHCLELYECDEEVVLFALRNPCVEWCMIPDHFRKQLDFVAKAVHLSNGSIWEDLPMETKCNFPVALALVTSPSTSEDLAMAAFAICPELFSSHKAMMCFIANHGGGDLLPMVLDSFPLSIRSDKELMMKAIKKDVSIWEHCSDELKVDRDIALAALEGSPNVLFFIGESYQMDNPAFVVLTIETHARYLQFVYHDVCKELWSNREVARAWLNSGGDWLDEFPEEFAEDEELVLILVRKNWSDFNMISDALKGDKDFILKAVAVDARIIRDVDEKIAYDKDVALAAISKDPRSLQFYSGGEAFEFIVSFAKLIRERLLEYQVFQKEIVASMDKECHRSNQISVLSMLNQGPATLAMYKDVITSYIGVLHDEEEIAKYCAVSNHLASWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVD1</accession>
    <name>A0AAD2FVD1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="160" mass="17892" checksum="371532DC9AD59F3C" modified="2024-05-29" version="1">MSLAELLNEQYEAYTQEVSTAIFSKIKIFIQKLDAYNQEFQVEYQPVYKKLEYVATDMLAAAPAWPSFDHEFLVRDVFDGVQSYTTKEPFVPAAVPPLLSLEDAQSIAMEVLDSTTFGVIIIALLVAAVTIIYASSIIDQGIMSMEELSIVLETPPFVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX43</accession>
    <name>A0AAD2FX43_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX43"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="96"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1954223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="473" mass="51569" checksum="2AC754B67A74E2A5" modified="2024-05-29" version="1">MEAIKAQRNQKKGFTILGQDMDVILAVFGNIVSWMVRQFVPSLLPRLLPAIDEEDTSDTPSRDQTKCIAIGRPGGSEQLRVITLKPGYATAGYNIGSPTLFVDVSSSLPKDTVVVKVAAFSVNFADCCIRWGLYESANKFVGWPIVPGFDIAGTIEQVSEDYSGDFKVGDKVYGATFFGSYSTRVLVPTKQLRKLPSNLTMAQAAAVPAVSLTALYSLHLGGQFPPGVAMTPKNNNNNNNGVDHKRKQSILIHSAAGGVGSMLVQMSKLLGMSQVVGVVGSTSKVQTARELNCDVIIDKSKQNLWEAAKEASPDGYHVIADANGVSTLQASFDHLAATGRLIVFGFHSNLPMGSDMLHPWAWWNMIVKMIYMPKFDTMDLVTRNRSILGFNLSFFVDEIGLLVQFYEQISDWLQKGLLKVPHVVEMNMKDISKAHELIQSGKSVGKIVMMTEEDDGGKTATTTSETYGSKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXT0</accession>
    <name>A0AAD2FXT0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS16205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1956381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="171" mass="19000" checksum="B9F2E3D07D28294A" modified="2024-05-29" version="1">MELYSATQEGDLERVRELLDNGASINKMLFSDSSGAGLTPLHCAIGNLEMARLLLDRGAALEPGDFEDVEEGDEEVTDDEEEDEEVNDDEEEEGEEVNDDEEEHDDESDDESDDESDDGSDDESDGKEKYIAPLHLACKENHLEVARLFLDRGAQCGCKDTFRCNTIALCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYH6</accession>
    <name>A0AAD2FYH6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010207">
        <property type="term" value="P:photosystem II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017499">
        <property type="entry name" value="Thf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34793">
        <property type="entry name" value="PROTEIN THYLAKOID FORMATION 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34793:SF1">
        <property type="entry name" value="PROTEIN THYLAKOID FORMATION 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11264">
        <property type="entry name" value="ThylakoidFormat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041946721" evidence="3">
        <location>
            <begin position="20"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1957070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="325" mass="35743" checksum="4355DDF45A4F8F8C" modified="2024-05-29" version="1">MQIQVTALFALALAASTDAFAPVTTRSSSCALSAVAGGLDLPDIEAELNYKPGQADTAFAKRFGHLVGAEVKTVGDAFADFTKEMGLSVNALYKNMVTDIVGTTHLIVVNARFQQDAVWSLGMLTSLDLLLKNYPEPGVGEKIASALFKSVGLDEAKIRAEAKSMEEWATGKSKEDIEKALVGEDPSSPLGAIVAGIKEDEFWMYSRYFGIGMVRIMDLVGIDMDKDEVYPIMEDWMKTKLGKTHLSACNDSDLYFRVKGKLDMMETMMKEIEIREKKRMAERLEAKAEAALNAAEREEKMKKEIEAETQANRERAEAAETAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ61</accession>
    <name>A0AAD2FZ61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS16752</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF11">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042242069" description="Fringe-like glycosyltransferase domain-containing protein" evidence="11">
        <location>
            <begin position="23"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="935"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="444"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1957520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1216" mass="133523" checksum="058C9A4B97A24A99" modified="2024-05-29" version="1">MKFGALSLSLLCCSFESPIASAQRLGVLKRKKPEYLRNADHAEAANGNRKLFFSSLIKKAEGVLYGTLSPPDESMSYDTSMSYGTEEDHIVYLPANMADDDYVDQSMSYETSMSYETSMSLVMSIETTEPEYVNRAPPPNNPSTFYTSIFSNGQQTRNTAKPAAGKGKGRKMMQLEPTETLSDAEYVRRYLGNSAADAMDEHDHRMLQSMSYTYSMETSMDYSLSYSFSYSMSMDTPQFGNQFPGSEDDLEAFPIPDVKGTSKLPRPIASHPGKKMGKAPAMQNRRRRMSREDWTRVVYADDEPSTTVEASDSSISYSLSYAYSASNEESMSYSMSYEYGAMSEDNMSYDYSSYSMSYEYGTLADESMSYDYSLSMSISFGTLGDDDGFDWDDDSVQGGALAPDSSAGSNPDSGNPSSGGGSGSGSNSGSGSGSGSGSNSSSGSGSGSGSNSGSDSGSGSGSNSGSGSGSGSSGSVSGSGSGSGSSGGFTAVKAPKGHGKAANAKAPNPNRASAAKAPGIPGLTRKNARKRAQARRRRAERVSKPKEMPWTSTEEPSVFLLESVKDMYQDFGAQMTATDQSFSSEIEGQFRSNLCGKPKCGGKINMFKCLSCSSNSWYSAISESGNGAIHGFVDRDNNVVVSSDEAAAPTHTRLDIAVPMSGQDGKLRHFAARLGASLQTFRKSPMGKQMSIRLFVTKYQGDFADMRMSDVKRELSYLTKLEPEDITFVDVLDSEFSRANAINNLHRNVCQERDCIVSVMDVDMFILPRFFYNAHEFVQAGHSAYFPIVWSEYNPETVQLVDDFYALNGVKQSTYSNHHGTWRQYGFGLYAISGADASKFMLDERFKGWGGEDNDFYHRVSSGLNIVRMREHGLIHIFHSKECTAGSFVKTSMIQQCFGSKTSVEGSQLGLYLRNLRESDEATFSSIFQMDRYEEDILLAVVTSRENLSSRVAAVRESWGATNNIPANVHIRYFVGNGTESSFDLLRLAGLEDADELVIMTEVEDNEYPPVKKNTNMLKRTQEVVLDMEASRNMDIKYIMKVDDDTYVNFDGLLKFLAYRDPTETHQFWGERGMGYVQDRDGLTKAGLKKPYCTGGPGYVLSRATFDDTVQGIDACVHGANVSPYRDYLWHSDVVIGMCVTQQTGIGCHEGSDYKKNRVFLNNYGGPENFVREGDLKNVVTMHPFKKEGQMSRQHGRFDKPVQKAMKNLMKAPSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G085</accession>
    <name>A0AAD2G085_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OsmC-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G085"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052924">
        <property type="entry name" value="OsmC/Ohr_hydroprdx_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368:SF1">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22613" checksum="4820F967148BA42C" modified="2024-05-29" version="1">MVSSFLVRSSCRAVPRISQQYKLTRRSTIIQSSLYSSSSAKYQKSYKLEGTGEGTKVEITTNTGHYLATDIPKPMGGRDTAPQPVETLMASWMGCTQATALFVGRHLPERLSISKMEFDNIEAFRDERGALQLPIDTTPEIPSRIQRITGTIRVYERRGNPISTEQMELLKEQTEIRCPVANMMLASGCAIDVEWVDGSFAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0P2</accession>
    <name>A0AAD2G0P2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0P2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF163">
        <property type="entry name" value="METHYLTRANSFERASE SMALL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="312" mass="34290" checksum="C367DE5AC6B3A469" modified="2024-05-29" version="1">MTSTNRPRNHLVTDATQPFDFTYQQYGKPVKIVVNQTPEEDTWPGGALWDIGVLLSHVMVGIASGTVLPSQKTVNLPNRIFEAIEATNSSNKADWTVLELGCGVGLTGLVAAAALGTQLTILTDLEVVVDQVTQPNLEINSSLSSEGKKKPYRLLNTGKRGRAMALPLCWGIEEDEANVGSMFLEHTKSSQKSRNTKKTKKKKGPAGSNIAENDTEDLSKPSLIIIGDVAYQHKPGAPSHFDALMSTLLKFLGPKTLVIFGTRMRMPASADLLEMFNTHMEECCEPTHADEIDASFGKFKHQITIHMFRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0X3</accession>
    <name>A0AAD2G0X3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0X3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="283" mass="31352" checksum="C270CDDC59CBA535" modified="2024-05-29" version="1">MTNAVSIFALDSDSEEDDNLHHNVGLNKQKSRAKGLPPSGQNTAAKLVGRRVWSKVAVSHSNGFCSIRKCKHDSLHPNHGCIQCKCGVHNLCVQENMLMSISKEDGHWYCSKECGGSDVLVIHDVGVRQVATPTSTPTTKPRSTEGAKIQEENLLVAEFEDCVVDLACPPQAEISISSLEELEKSSEELEELFEDSDDMDDFELEEGLEELDESHDIDESELEGSGDMMSGSFKLQRSSPLMAVTFRKRMIIAGIKLNIMKKPGKIYIYTKLNDSMYSTPTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2D1</accession>
    <name>A0AAD2G2D1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002055">
        <property type="protein sequence ID" value="CAJ1960237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2D1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="20746" checksum="365105995EA28948" modified="2024-05-29" version="1">MKTKVIAGFPNDAVDKIEIHKGVRKIFDPEYEDSAEEDASIGDKDNGLDSDETDDDSEINNKTDDDADDDDEDEASEESVIIVESTRPTDNESGGSRSGRGHLAETRTITDETVSELTGNTGDESDPELASPPRKKRRSQRVSIDEQATKMDMDGTDPSICSRPSGKRLHPATRSTKPAIEAYKERSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2G7</accession>
    <name>A0AAD2G2G7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FIST domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002052">
        <property type="protein sequence ID" value="CAJ1960204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2G7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14939">
        <property type="entry name" value="F-BOX ONLY PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14939:SF5">
        <property type="entry name" value="F-BOX ONLY PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIST" evidence="2">
        <location>
            <begin position="50"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="602" mass="65083" checksum="B56782E782D33D75" modified="2024-05-29" version="1">MKRAAAKDEIGGDGVWFQNTMETSADTSSKEALRELLRDWQLGTDTNDDDQLLVFLFLSHHWELQDVTSNAMDLLEEMSMGGDEKSSKKDNIHLITVIGGGVIGQNQEYEEEASHPVYGRKAIKKQMSILGGYCKKDEINNPKSSESSSLQVFSMSNNDATVKRTMTTTNQGTNPQQPQPFRSDSSLFVFSDPYCRQIQNLFGELHSLNCQVAGGISVPHQSALYDPTLAINREILPKGSLVGVQLPSNYQLQCVVSQGGCRPVGPTYRVTSVDGPAIHELDQVKALEQLDRLCSNENQSSDEDDGDDTDFETTVTILSPKDQELIRQGGVLAGVFLEASSCSGVDDQLNDDESPSLQPSASIESSSSSAAQDSTEAEGLVEGEYMVREVTGFRPRSGSILVCGQPQVQLGDLFRFHVRSSQEALDDWKLLLKQTKMEQLFLSSKADEVSLDATESSAAAGGDGNLSSSSSSSPSSTTTTSRIVCGMQISSLARGKDFFETPNVDLDHAKMLLESKKNRDNFNDSATPPIGGFFSNAEIGPVGIRMGAQGDSSQPYLHGFATVVAMLCEITTIPIDDSSQGSNGSEDSDFQATISSSQSSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3K7</accession>
    <name>A0AAD2G3K7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS17472</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3K7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010277">
        <property type="term" value="F:chlorophyllide a oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013626">
        <property type="entry name" value="PaO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08417">
        <property type="entry name" value="PaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1959028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="416" mass="47167" checksum="E7D82FE679EE92DE" modified="2024-05-29" version="1">MGEPFAVWKNPMTNSWSVMSDVCPHRLAPLSQGRINEETGCVECGYHGWQFQNDGTVSVIPQMDKGKSSVEKVKPATSFAVHETGDLLWAFLPTNLHGESFPKTLLHEDYYFPGLKMDMARDATYYVQEMPSSFHMIVENGLDPAHFSFAHCGVIARRDDAAPMPDMKVVSSNFTNLDIYTTYKRNGESRERIYSYQRPCLLYNKEKVPSSNQEDKSTWLPAVLFFLVPIREGRTRIITSVEKVSKSYLPAWVTHLATRRLFEGDYFVHQAELNRVEKNLKYVEPTTSDTGPRAWNKWMQQYGFSDSPAHTFGTASKENLVPMNFAEMQNPWRIHTSTCSKCRAVLRRARKTQRWSILGGILGASLLQGRKKLSVAYLVLSAGILLHFLAKKVTTLMEGSSHPSDAPERSFSMSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3P4</accession>
    <name>A0AAD2G3P4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3P4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042132000" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="328"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="661" mass="73962" checksum="D052DB0780CE4724" modified="2024-05-29" version="1">MIVRIRSIGHGIFLTLSVFATKIVALNAEESNHCDANSHHHGPSSCAAGESYNNCPLWLAPSYTGTDREPKYGLFAGKAYGVNETLPVHAELAIPLVDFNFQPTEQFQRNPAVSLPNHHAQLIDFLEGFFWTANFVGAQCEGEYSAPAAIPGIGVLSHYHSGISNVNFHQASVLLRKSPSFLKAGEPHLSRGAITTYHNVTLQATREIPLGMEFFADFGDVWDETSGDNDDAYQDTIRRSDYEKADTIISDLVTFFQEFPDLSRDLQEEIVDFMVDDVLGEAAGKHAKTIRSLIPSSPRKVAQAQAAGGSFLYRYREMIRSSDWLQQNGFCLDTLRAGPSRIPSAGWGAFATRRIQKGETITVSPMLHIADKEILNMYPVGETSSSTQSIGKQMILNYCFGHPESSLLLFPLGSLATLINHQSGKSSNAYVTWSRRVDKLPNQHQYHDYTVEQMAEVSKIVLTMKVVATSDIAEGDEIFLDYGPQWVAAWNDYQARWQRDKQGNSHPLRAQDLRDQYRTKPFAAARTKRPPYPVGVATACFLNVREVPDGKPMFDEALRVEIVEWSSPTTQQDYHGRNLFIVDVLDRAMAPEHFFNYTVLAKFAEDRIEEIVNVPHEACTFVDLPYQGDISLPGAFRHPIGIIDGHFPQKWRNLKGTKSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5R7</accession>
    <name>A0AAD2G5R7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002160">
        <property type="protein sequence ID" value="CAJ1963855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5R7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="468" mass="52379" checksum="889222CA6AC0C403" modified="2024-05-29" version="1">MGQPGNIFLLRVLTPRHVATHQSRHILPAHGGPHRFPLTFFALRFAPSLDLTVFFLQVLAVPLNRPLPTAHPSFKRGRRLPSFARTILGGFQMRSVHGDEATLADALLEGHLRVISDGSFKNELETAAVQLLAKQGGCNRIIIRCQTPGLPQDQSPYRSKLIGLLAGIMAVDWLLKQWFPNLLTCPKVRIACDGLSAIEMAFEDRPLSPTDAQFDLVSSIREAILRSSVDWAPQHVYGHLDKSNLFDELSWWEKRNLEMDGMAVEYRKELETANHLIAPNPRFFTELAALYVADTKQSRLDPQFIQECVTLPALRSRWRDKGTISAAAESKIAWDTLGRAMRSLPAGLQRWSTKHCVGMCGTGKFKVLWGLETSAACPRCGDFEDHLHAPRCRAALATVEWDRRTAAFSAWLDLQLTGPSIKTAILQLLHGVRTPTTSPLRTISPSVHIPKKHTIKNHTQIRVPKQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5U5</accession>
    <name>A0AAD2G5U5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002160">
        <property type="protein sequence ID" value="CAJ1963859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5U5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="632" mass="70423" checksum="532873584F5CC866" modified="2024-05-29" version="1">MNSIDKPDTDVQRDSDGSVGDQAQNSNRFASLQSDEISSDSSGTQEFDEVKVVAVQKNPSKEPESSDEDEDNDADDTEDRRTIVDDAMEEDDDDEWVSSDGTNTHDEAMDDNTPPLTSHNLTATQDSAGTGILMEPSETTPPRVQRPPTLAERISNLIQVSMEGVPGKCHIFETTFSVDYQGSDSGTVAAALLSTVLNSMEEAINNSPHELKLLPISDTTYKQQNLWIRNSVDLRNRLPTYRTLLTYCDMEYGNGPYAATNSKPGEKKLRTRLCVGFSSEASVEAVQDYLHTGLRQLGRGAGCYPSPLQYGEIVKIGSCSFIPAEVNFSAYAKELMRLFDFEVPIIIKMDWVSIPYTGQAKYDKRSPGVTSPHCLKHVKRFLIHHLCELTDTQADRVLGKWIPKSEIQATRRKILVWCTNTLRAIQASDQSNKVEEALEFLDDVIEDTTDVHQGQLSIDMDMANAKDIDDGQTVTGMLDEMHEREQQLEEAFVEIEPRDNALAAKDQALAQQKAATAALQAQLEALQRQTAHHLAIDSQPPAQNNEVSPDRSEFTTPPKKRKSKDTSTVKRSVDRSTAGLKPPTKSTRTSPSVHFQQPKQRSPGKSLRFTWTQLRWRAILLQPCPRTRASHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7N0</accession>
    <name>A0AAD2G7N0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Insulysin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS21350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7N0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="112"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="271"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="12">
        <location>
            <begin position="468"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="13">
        <location>
            <begin position="944"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1965758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127441" checksum="475B16627F78DE90" modified="2024-05-29" version="1">MMSLQNEVQEGPDLNPSRNPFDKKEYRHILLPNGLRALLVSDTVAMAQNKQSSSSSSSAMDDDGGDSESKQSGTEEEDEPVDNGLDEEIEDEQDEDEFDEEESEAAGGGIRSAAAAMIVGVGSMYDPPEVQGLSHFLEHLLFMGSKKYPSENAYDKYISKHGGSDNAYTESEHTVYFFDIPQEHLEGALDIFAQFFIEPLMLESSVERELNSIESEFQLVKNSDGCRLQQLMCHTCGHGLGDHPMPQFSWGNIQSLKEIPEAKNADPLAILREFYNEYYYASNMRLVVVGAYSLDALQDYVVKSFSDVPQKGTDFSFDAKYEPKIKNVGMPFTSSSLQKVYYVIPVRDRHAITITWQVPSQMKSWKSKPCDYLAHLIGHEAEGSLLAALKSRGWATAACAGVGSEGYENASSHALFMVSMTLSEEGVTHWQDIVEEVYRYVGMLRYHCDKGLPLFLFDELKAMQEMSYRYEDEPSPEDLVENLAEMMAPALDLPANKLLDALPLLYEFDPVAVADLLESYFTPANSRIDLTSTKFGRSADFEDSKPSKKIAAVDTPLTNSLFDPTGIMPLQEPFFGTQYWCQDIPNELQQKWTAISQAQLPPPESSLSLPKQNKFVPTEFQLKPLPTDIDPMDVDTPMVTEEMAQDADPDDNDESAGFPSIPPRLHPSQLPSLLCDTNVLKLWHLQDQVFKRPIAELRILIRCANAGKSPLHSACSDLLVRLVAESLNEVVYMASMCELSTSMSSTDGGFSIRVHGFDEKLMTLFGIVLDTLLSFRGEDNSTLPRGIQKDLFDLCLEINSRRYANAGMKASSLVSDVRVKCLRPDLWSSNEKLKAISSLDIPTFLKTVSEVLGNIAVEGLYHGNVNVSDAQHAQSEIIRLLEASGGAVGLARDEYREHLVTKVPSATDITLRCAAMDPEEPNQAVEVYIQVGEDNTLDRIMVDLLVEMMYEPLFDQVRTTDQFGYHVSCDSRWTDGIIGIQIRVVSASKSAEEVNARIEKFLIDFRELLSKMSRDDYFEQMIGLAKQKLEPFNSLSEQTGHFWSEIRDGRYQFQVELDEVLTLRGISQDQALEAYDKWLYPKGSGTRRRFSVNVVSVNSLISENPHLSQEMCGDFNDERINKFQEICKNQTFSQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7N2</accession>
    <name>A0AAD2G7N2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7N2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992:SF9">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="520" mass="56287" checksum="D3A47DA352C0C2D6" modified="2024-05-29" version="1">MISEGTAEGIGSAMATGGSQTSTTKALLVFIHVPKDLQVYIDKQEANKENSSSIAAAANKNNSNNKPSHKKASSSLITASTNKSGHRKSNSILRGHRKTDSFASTRNKIPILPLDDLSLDNYNNSNNDNNGATTSTTRTVHTDNTTDATEKILPRSRAPSIDETVTDSEIVPGQHAIGYVESEDIDKSTKQAVIEHIVTAEEMAAVVSLELEDAKEEGAVWVSLPTMTMKLRPVSIEKKSFKLSRPKRLWPFCQNPNQPREGCFFTAPVTIDITKGGGIAWTQFIIMCKPNSIDLLLERLERIGVGSSVGMISVYKSELLKTADSPDETAIKMEVEEENKKEAMKRGIKGRLDDVKLEEVKQEWKNAASRMRVEQIKEQIHEQAVRNTFDFLALLLIASILAGVGLITNSTVVIVAVVGFAAAFSQYADEWPTPEMGSRGDVSGLITGIAIAIPSGMGVALSILGNNTASLVGVAISASERNLFSSSKGFNTNSLIQQTSIKMGSTLIDHCCDSMMNCHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8D1</accession>
    <name>A0AAD2G8D1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GPI inositol-deacylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8D1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47909">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47909:SF2">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="57626" checksum="AEEF60E75D00A6E9" modified="2024-05-29" version="1">MSATKAEVETAFDVIKARTILKELAQAESTQTKLGLDQVKNYQTAIANLPPPPDSLDVDGGWDLLATISPKAEEGDNVDFFDANSWKNYISGDGPSPFQSLVTGSSRVQGLAQWLTPKDFDNVVSFSFGASLVLKADLEKIENNKRVFRFRRGFFVVPFIWGGYLTLPYPVPFNLLGDRAIGWLNTIGYDESTGFRAALGNKGTQFIFQRKTKEGSNEPAELSDLIIQASEMYSSPITDHETDEEERQLNAGLTKRPVILCPQQFGGKPGDYTVLTAGLRAKGHPVYLARISALQWLSIAKSAFSKAYFEGSLEPSKTLPFYNKAIDEALARMDANSENGGASSSSSSALPEFTLLSHSIGGWVARAWLGEVASKSVKERCKNYVSLGTPHKEPPADSIVAKVDQTRGLLKYINDRFPGAYYSPDNQDKDDANCNIEYTCVASKGVVGKLELKLDSILAFASYFALGGQGDVEGDGITPTKGALLDGGNSIILDDVCHANLLPNPIGGRNAKLLGCSWYADKLDEWVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8H8</accession>
    <name>A0AAD2G8H8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8H8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="224"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="319" mass="36311" checksum="3EF7F9216E281D16" modified="2024-05-29" version="1">MLFKQDAVRSLSPCWKSDGEEFWAGRSINTINSNARDEDLQQNNVFGSRANLEAEDFTQSVDYLDLMKDVEKTYRELTPIPPAMPETQTWNIEAKQFLHSGQHFDPRQLNPAAASEIGQIGGGHQDQPTAERPRLTLSGDELFPESHEPPTDQQKPEAVEGNLKPPPYNPSDHEEVDPHQRNRSASSINQLDQDLAEKSSLAASAALAAVVEIYLYDDDLTPQDIILGRGGGSNPIKSEGNRRWLDIIAPAWKLNYKKLTRKDDKSRFAKTLIFWLRSENYRFVEPTKDSAGQKCWIEVRHEDARIYNKVMHKMRCTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8T2</accession>
    <name>A0AAD2G8T2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8T2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="245" mass="27997" checksum="302C20EB57EB4E6F" modified="2024-05-29" version="1">MYYPSTPERQQQPQSIVHHLSRMGSKMAVPFRMKQCSPLRRRLKHGDEEGTLQSSKRTTVSTSLTELQDTVYESNDEFSATSDWFNDSDRQHHFSLHEEDEAKSTSSDEETEDVFISLDQNEFLMECLMTNQCSDVTFIVMFSAGSCYLSKHLEEIVAIRTAKSGCNCQCRRVHSRKAPMFTQKLQIDVDQPTLVAMKNGSVIGKMSNISPSGWELDKWLTDTNLMTKRDSESDFQSLSTRSSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9R4</accession>
    <name>A0AAD2G9R4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9R4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF329">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR DMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="820"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="860" mass="96969" checksum="E8C248D02447BE50" modified="2024-05-29" version="1">MKRCRRWVGKLRQPITKHDKLALCSTSSLRSNNIPTILSEIWYFGMFRFVTSSSNPNIKSPLRRYLTGSPSKRAPNHQYRAVQWTKLEAETKEMLKKIELSLRQDGIHSTKTSSRIKDAVTSQDTFRLVGQWSQLASISPKNKNAAIRCQEVLEILEYKCKDTTLEPNRHYYDLLLQALCHTGQVQVAHEILLKHSKDGIETKEMSGRLAKVSAKSFHIVMNGWIADQPKPRRNSSRQYQQEVLQQVQELYQSLESLYHSTGERDQELRPNERTLTALLVSWAQSERKDAPNKIVQLLRQASEQGQKVDLVLFHALLQSLTKATAPKSRSANREAFRQSAEFCEHLLHMAISQFGLTLTAQSYSLVINAWAHCEAMEQKGQAAERAEKLLRLMMHSYSTDGANVKPNTLTFTTCMAAWSRCNRPERAHALLEELMELYDQTGDLDLKPDTVSGNAVVLAWSRSNTSSAVTKTKEALENLQTFATADLISYNALLHAYARSGMYREALTLVEELEENGISTQNSRLLPDVVSYNCVLHALVRIKREEAKAALELGIGLEAQKLVEKMKALANKKNRAQVAPTAATYTLLLQAYAKKGNSTFEYDNTLSEAASLGGIHMILEDLGLSLSSTNRKRKHNATTRLDAMFFSALLQACSSFHQVRYHHNEASTLAFEVMVRVLEAFSGGHGQLRPITSRLPTLSIPQFPAFRIHDDWLFVVMVETCDRVIGASVNNLGPPLELVDDATTANPDATDLGHSSRPVIISGPKLEDWTALIVAIVNRVEKEGYLSRRVVARLQGLSKTLARSKHDSHCKPRQIEEWLFPDAKNDNSVSGSQSNEHDDGNSRREWPREWSRRIPSNHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA70</accession>
    <name>A0AAD2GA70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclease associated modular domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA70"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003611">
        <property type="entry name" value="NUMOD3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07460">
        <property type="entry name" value="NUMOD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclease associated modular" evidence="2">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="380" mass="43039" checksum="D8CB386E8646DCBB" modified="2024-05-29" version="1">MPKRKSKDDEDDDDDEYNPEGDDSPEEELLGVDDADDDSNNPEGEENHKGGQPDADENGEETTGDTKQKRRPKKLRRKIHYEDPEIDLLPSHERKTTAGGYAHTNKSKEKISMANRGNTPWNKGKNRSSADRAKIKAGVQARNRAIKLEKLRRLGMTEEEYDKKKKEIKYLRERVRRTKLANDRHAAAQAQKKLQAAIDATSDKVPVKELVKKIHEEADEEVVKIQKEIKVFSEEITWTPVEVWKEGDSYDKICPSGGPGGLICCQECAKKYSSFVDDTMKDLEAQRTHKLGNEVKEIATLLEQGRSDLERIGSVARRKPPPTNRRMFQSDHPRATSTSASKSRASLNSNQRLGEEDQEWNLTSTFDIVQPMGGTEVWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA94</accession>
    <name>A0AAD2GA94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS21295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF17">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="53"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1965702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="391" mass="42528" checksum="B52AA3058A3CC22C" modified="2024-05-29" version="1">MSNRKISVCCRHHPDSISWDKDESGAEEPVLGSVDLENDNLDLYNHPRYRRAMILKELATRRSDEGMVTFETPSQAASNLDIYRKIHSDRLIDFFASAWKLWDGIGPDGQDSMCNGGGGKEASSPALIPGNIPLPRERFQRPSKNVMGQIGFFCTDTCTPVFGAMLEEILWDGAVIEQAVATLQKSPSVVAYALGTHPGHHSAEDSFGGYCYVNHSALAAKLLQERNGYSKVAVLDVDYHCGNGTASIFYQDPSVLVVSIHCHPDWDYPFHSGFSEETGDAEGEGATLHLPLMPGTNWETYGDALQSALTKIQDFGAEALVVSLGLDTYLGDPCAVRRAGFRLEGDDYTSIGMAIGSSNLPTMVVQEGGYKMDSVPQAATDFLFGICAPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAE5</accession>
    <name>A0AAD2GAE5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS22691</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002318">
        <property type="protein sequence ID" value="CAJ1967262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="488"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="1121"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1967262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1570" mass="176434" checksum="C92AFD86E37ECD49" modified="2024-05-29" version="1">MYGLVFEIIEEWVIEKQGLDVWHNIKELAGNKRNDQTYLRRAYYQDEELVDLINAASEILKISVHDILDAFGRFVIMHHFANGYAELLICQGSTLRQWLSNLNAMHDHVQRSFPGENFIAPIFWCEDCDEVEGSIQLHYYTLRGTLLVPMVVGIVEQLASYHFNLEVKMEQLALQGEDGATFTSWRISAVDESQKWKLSPLASSQSNEGDKPISFDGVSLPDKCPFSGRALKRSNHNTNDETSTKCPFHANLEGASESSSPSETEEMTSVGSLSGPSDSCADFGFSGQHLKELFPFHILVDQHFSVLQLGPKLPRLLKKSFSQLDGVHISDIVQITRPVLGTSWEWKSLNKLSDQNFFLTPATKKTSLHKKVSMADSTIQFQASMYRLTPTKVMFALTPNVQNVNELNRMGLKLTDLPLSSCQRDAVFLGEHVAQEADKAHKLDKLSKRLISEKDLSNTLLNNMLPQKVAEDLRRGKTVEPAFHEHVTLFFSDVVGFTSICDQVEPWDVIDMMNQLYSVMDFLASHFDLYKVETVGDSYMCASGLINPDDYHAEKMANFALAVRECVQQVKSPIDGSPIQLRIGIHTGSCTSGIVGTLAPHYCLFGDMVNTASRHESTGLAGKIQCSSVLYGRLEHFSKKDSRQYNFKARGLVDMKGKGECYTYWLESAAEGNTGVNEESLASLSSQVQGILSTNTWKKRRYFGRGGIFRSNADSSDVSVSGLSFHDGLTQSFTSESLSSLLGSEGSAHNGDDFTDDVMDDEDGTIPNTTIFDFPEEDTLQIPRPWGTIGSHKKEPVEEAIGKSLSRSLATCIQKGGRRMQMIEDQLQAFVSLIANIYDSSLNEASLDYITGVLQRANILWEARDPNDRSPCALGANPWDHFTLLFSAFIHQVKHTGSTNATLEREKHIVAQMYEGLQSCQERRSVDFAFTLLEDEFGELYDEITFGCPNFRSLVRKAVLCTDLENENTVREMLGNCAKLNSMDNCADERQSRQRNTANIGLILAVATVGQCTQSLDQFLQYCGEEYDKAMKASDSNSAESWYYEQSMFMKDVLLPLIEEVLPVLPLSGYLEEGAAENIAFWDKRGQEWMVASKLKKAKLHGVIEGSVISKYQVEKLVSVNVATLETLLTQVMTTRNGNEPRYLDDGVESTSRNPYGEIQMFIKMKKSTIKSGNGTSTIHQVGADICSELRDFVVTIAARYENNRFHNFLHASHVAHMANLLVKCIHSTEGSNGASNIAHDPLARFVIVLSALVHDIGHTGVPNSQLAEEQPELADKYSRKSIAEQNSIDTAWEILMSPKFKKLQCCLFESKQEKARFRQLLVNCVMATDIFDQDLRVLRQSRWEKVFSGDEEAHCKATSAIEHIMQTSDVAHTMQDWEIYCQWNESLYRELHDAYTEGRSTKDPSDGWYEGELWFFDHWVIPLAQNLKACGVLDIVSDQLVKQARSNRRRWQLEGKQISQEMCSTIQSDTRSSCCSHSLSAASEHSGSSASYLASQMVTEAESVSKVMARYERKYEAVLGNLIALAYKGQLPSDLEQQELSDVHKHFKDQDWYRSHADNAEVSFHYEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBR5</accession>
    <name>A0AAD2GBR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CYCCA115_LOCUS23438</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002413">
        <property type="protein sequence ID" value="CAJ1968874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF45">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAJ1968874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="32308" checksum="49AD5F572981B1C2" modified="2024-05-29" version="1">MMFQQSSRSLLDASKKSSSFRWTSSVGRTFSSRSPQDWVTTEETDDPSIAILKMNRAPANTLSLEMCTEISKAIKELESNKKTQAVILTSSLPTIFSAGLDLTELHNPDKDRLPAFWGAFQQLYFDLYGSRLATIGAINGHAPAAGCMLALSCDYRIMSKGNIGLNESKLGICAPPWLGQQFIDTIGLRKAELALNMGTLFDTKAALDIGLIDEIVGEDDVMDVAKTRASQWVAIPAPARVACKELTRGRQLNELKENRKQDVDHFCSFVNQEAMQRNLGFYFEQLAKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBS3</accession>
    <name>A0AAD2GBS3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS23357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002402">
        <property type="protein sequence ID" value="CAJ1968696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBS3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF2">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1968696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="176" mass="19784" checksum="E7E65B4B270F1DF4" modified="2024-05-29" version="1">MVAQAEEAVREAEVEDIHQDIHLVEPQWENTIPDDLVDHPLLLAMQESHSPFLITDPRLPGNPIIYINNGFLDMTGYSQTRVLGRNCRFMQGPETDPVVVAKLRDAVDDGRDITVTLLNYRADGSTFYNHIIISTVKDPESKEVKYFLGLTEEVSTPHGQPRLVSMPVSDPEESES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBU5</accession>
    <name>A0AAD2GBU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZC3H15/TMA46 family C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS23483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002414">
        <property type="protein sequence ID" value="CAJ1968965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZC3H15/TMA46 family C-terminal" evidence="5">
        <location>
            <begin position="151"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1968965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="274" mass="31246" checksum="D9391B9F283F5A13" modified="2024-05-29" version="1">MAKKKNAPEGSKKADQKRKQQAIEDRTFGLKNKNKSKKVQMKVEGIKKNVMKSGDKRQMALEEQRKKVKAEQKARRKAAKDEQDALFGEALLAIGKKKTTDQKGGKAEAKGRDADDDANKKTTSRAMKMMYQMDAKEMEERLKEDPNYVPTLEDKIEAERQRKVEELKKSGKGTKVTPESFAAWQEKKRKRRAEAAKKLVETELRKKKGGKGLAVLSGRDLYEYKRDLFTLVQSDDAQNDEGQLDESDPKLKDVASKVEELFMDDTNLDDLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GEA5</accession>
    <name>A0AAD2GEA5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23805</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS23807</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GEA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1969628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="168" mass="18549" checksum="F67570362BE6AB66" modified="2024-05-29" version="1">MAPCSRKSLLEEEESDEAEDADDTEDADDTDDTDDTEEAEETDFTEETVFTEETDFTDGSDWTEGSDLLDILVEEDLRELADADLIVAVATGTATVTGANEELATGTVVCKRRVSRGFLAKMVRGAATARMNARMRANLFILVLMMVECLLSFLVFIKVICFCLCEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GET3</accession>
    <name>A0AAD2GET3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002458">
        <property type="protein sequence ID" value="CAJ1970067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GET3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33471" checksum="7C002DDD5CE975F1" modified="2024-05-29" version="1">MTYYQNAFYGDDDSYSAYYNNNNIENYDDGTWTCCNDRQTLFILFYFAFCALAILFHDTILAKPVRLIATFIHEMSHATVCWLTCGEVRGIQVYENDGGVTTFVGGMRCLIIPAGYVGLAFSAMTFVIMSAGRYMATVAIAGFTISLLVALFFSPNRLLVCISLGYAMVNIIVTLIEYTAFTPILQFLVLYYGVTVGMYAIIDIHDDTVFAAIEGSDAHACTTQVWPCCHPQTIGLQWSFMAILFQLIGIWVSLLQMSHECTDLGFMQCLSVGFGASMEDSDIDFEGLWVQFSNITGRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GF84</accession>
    <name>A0AAD2GF84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS24430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002513">
        <property type="protein sequence ID" value="CAJ1970412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GF84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1970412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="81356" checksum="2E8D185622AAE629" modified="2024-05-29" version="1">MDHQILDTSTSEEYEGIDQFREKILAILPIPSSILSIIGSSVILYMAFSTRKERKWTTYTRLLVGLSMCDIVSSISLGLAAFMRRPESERVWAMGNDATCAAAGTLIQFSYSGLFYNAFLSWYFVLTVRFGVKHDVIARKFEPIMHFISVGYPLVTAILGAILGVYAETSTGMGCWVNNYPDGCGEGPGQEKCQSAFLGFFYFGLPYVFSVTCIDINNLIIWFYVRKHRMPYLLNKTKQRSTARVNSSLFSKDNHDENSLSDGIESLDRELPSSIGSNKSSDGIIVNETDSFAASINHHKKYAQADDIDHSERDSSSRANKDQMRRLQLVSSQAFLFVLSYALCNSWMGLQMIAEGVTPEKDEPKLMNDIYGLMVLNAIFAPLQGFLNMLVFMRPKYVKARHQFPRETRAWAFRRAVLGDGVGPEQRGARRMEEPIDSIPNSGSATPQETQCTLAMMRPAESSTKNSIDQTNHSVPLPKGTMMMSSLTASLGDFDHDGQEEGMKPERTKGAFEASCSSIPRFHFRSSLVENTKRGLEAISELSESVFDLSNGGDRWSSSADVLSPITTSLEASRRFDAFRNDDTVPSSAMRLVAPKRMDSGCCEVFDEVRHEEDGIEPKREDMKEEEEVEEVEYAVDMPVRIPLRRLSMGKKSHGSHSFHDSCYYSSSISSSCSLIGFSDDDSDSFAEDNDGDGDHYDYTYRHEEEFKASEDFSTPPTTTKDGEAAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH15</accession>
    <name>A0AAD2JH15_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001748">
        <property type="protein sequence ID" value="CAJ1948651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH15"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="305" mass="34087" checksum="C0DD89A4DC7D2842" modified="2024-05-29" version="1">MKDNIVNPPEKDPNFIMTVADQGQGGLEAKTRSNSTTQSSIALTTDNPAITTPKRSSKRNPSETAEDGAMKGHSLFPSEVPQGQDVTVNTCPNLTTPLSIKLTKDNLPDPTTSKSQRKHPPPSKTAKDGAVQGRSLVAYITKLKGSKFHRLYKKAWRQEMFALATAQRVITTDEKSPCFWEFSLVFDPTLIVQRVEPLTWMWRTASEFFANPAIIPHIVEEFERLKQELQIAKAQSKFPPKQGWNQTELLCYLHTTTILFYDGCAAHQKWSPTMGSNDEKSQEMALKSTRTAPEHAQEGHHPIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI64</accession>
    <name>A0AAD2JI64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sialate O-acetylesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS13791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052940">
        <property type="entry name" value="Carb_Esterase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31988:SF19">
        <property type="entry name" value="9-O-ACETYL-N-ACETYLNEURAMINIC ACID DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31988">
        <property type="entry name" value="ESTERASE, PUTATIVE (DUF303)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041951803" description="Sialate O-acetylesterase domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Sialate O-acetylesterase" evidence="4">
        <location>
            <begin position="93"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1952937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="503" mass="54858" checksum="48EBCF3028098E50" modified="2024-05-29" version="1">MILSHLIFSALACVFLTASRVSACVDDDERIAQLAAQQGRDDISACVDVLGGCSLPNQLGQVLRQVCCQTCADNDAGNSGVETSLPGTEETIQVYLLGGQSECVGQAEATDLDADSQGYPELQGDIPGVWFAGYASPASTSRFFIAPMNAGTDRSMFGPEISFGERIYDVTGKRTLVMKYCVGGTNVFSQWNPEQQDNMWDTSADDGTAQWMAENAGLNFNSKNHLFKNMVYTIRRTKEALTSGGVPYEWAGIVWVQGQSDLGAGDWKFFGENTARVWNGFRQHIGSNDDVPIIDTGSTTHNQLKSGKEYATQIVKGCKAKNVEFALASNEDTSSDCIPGPGTLCPDAPNLHLNLGPFLYYGYDPAFPDAQKNCQVCDEFHWYRRYPTNLHSAYEGMILKGRMLANAFLREFSNIDTTTIIIEEDPAIRFPWNRCPDGTLPSAGNFCWIDYRDGSVMNEPCTNDGSGNTSSPDESSSTVVDSTMMGQGLGMISVTVIVLFFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIL6</accession>
    <name>A0AAD2JIL6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIL6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF26">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="967" mass="108985" checksum="23C015AA47F2BA6A" modified="2024-05-29" version="1">MSHNPYRRNNGRQQQAAAPSSARPIVNPYASRNNNNNNRNRNANNGNLNGNFGRTSALSLMPAGPLHVASPQGIIPPPQQELLNTTANTTHVHSTTHSSNLTNEMNDNNNEYNNIDNYGNVDRIGVSGQDGNGLGNDMHEMTIDVNTSNHHRNTNTNNNNSNNNNSDANRQVLQLQAQLKALQQEVLEQSESNFELNATIATMQAEMDHSISASSEKHKEETSKLQHLLRLEQQKSRRLELQQQQRMQQQQEHSMPVRKRPASQSVFTKRLEAHAGMTAAAAAAAPAIPQSITLPTSNTTTNADDSVLVGSDPPQTPPHKNNSSASALNDPPDFAIAKRADNTTTTTTTTSSPMPTVVTDTTSNTAAESSSRSSASRLAQHILQSLIDNNDDDSSSSSIRRRSRRRHDEAKKSDNDPKANSGNKNNMETSTQQQQQQQQQQQPVENDDNVDGDNNDTEMAHEISPQQEEEGVASRDHSQARRVLIDISSGYGQAWSEVQLVEYILRLDHAWRLWYPALEKSRLGRKQLLQAIVQRHETLQDSSSMTDGQDGDDNVIGKGSRITRLGLPGGNTKALDSSLETNILNSLLDPWWDHTSMASVQANAALRLVQEPKTVVEDLTTIISPLLAYTWIQKLVESIKTKDNQFQALRLLQLILEECSDTHDQTALWEICRQPMEQVLEGLYRQWMFEMAKLIKQEIANNQNDIMTSRLTSKSKKRGDARKRRLEAMPVEELSMESRDIGDVEQSLAHSLSIWNALIPSTTVERLELWFMEQNGARTVSLVLDMLEEHEHLYDKRNRPRRPTYYVIKGWYLDAIQFLSTIGTSKSGMDVLRTRTHPSNVGSDSYWMGNSLDVAIEQLFSLVMDQEQDTRKRSDDGFHARTLAIEKWVRLWHQVLLFVQDQQLPDKQPVALSFRSLVLEHQDWYTSACAVLLADQERTRQDIQAMIRLQLEELSLDEEEYEELRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIW4</accession>
    <name>A0AAD2JIW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIW4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="89"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="203"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39254" checksum="AE7EA3B4B16D62BF" modified="2024-05-29" version="1">MADQPTDDDLKRAIAKLIPTVDLQSTGIKAFIKLLSKEFGGADLKARNKFIKKALEEAINAMSSDEEDSNDDDEEEEAAVEAKAKKPKGLAQKKKISKKLAAFLGKGDTMARTEIVKALWEYIREHNLQHPENKREIILDDKMKEVFGCDQFSMFAMNKYISVHVDPFKPLDLTTKPKPEKSKTKRKRGSKDDGKPKAKRKAGAQPPYRLSPELQLVVGGKEILPRPQVVKALWVYIKANGLQNPENKREILCDDKLKAIMNGKDKVTMFNMNSFVGQHLVEKLDKSAYQHEDDADADAKDTKVAAVVKDEEVDDDDDDNNDDDDDNDNDDDDEVDEVEETGSDTEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ64</accession>
    <name>A0AAD2JJ64_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="191" mass="22267" checksum="444A0204A74EBD61" modified="2024-05-29" version="1">MDRSYTLWKKRYLVHVPAEGQGHVRCSLCNTGTFNINASNPHFQGNRHRKRLQAVFNSSNLTIFDGPELLDRVSKLGFEGWKDDINSKLMEYLFVKGTPRWPYGQNQFAFPTSIVDSVVKYERMEVASLLELVAWKLNCLHLNGSGNFMTMQDILDQWAIDESFDPVEYKRQHRFSSNVGIIMDRLLEFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMF5</accession>
    <name>A0AAD2JMF5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="165" mass="17612" checksum="E98A93CD485A9F9E" modified="2024-05-29" version="1">MARKTSSRKARGKVANSSNEVLDGSEISEGRRRPPPSLRHRKKKNETVTAADTTATSGSSTTSIPQETTTDVMDLANDDNHAPNGIADAVATDATSSATASHGQSVNGGMTTTTTTTNNNNNNNNNNSHTPDCQCYLRRLNNSLFLPPSLLMMDDYEAANKGSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMS8</accession>
    <name>A0AAD2JMS8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21272</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21274</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="188" mass="21412" checksum="D746E178B9ABF6D6" modified="2024-05-29" version="1">MGNDMFFIKKGVVSVANKDGFHTTLQEGNFVGEMALVNNKPRVGTVTCLTPVEGVTIPREYFEKFLITTDTNVRMNMYRENKAREMSRIRMMLRQAGHLHTKKLRKGDVLFKQGGKDKALYIVIDGEISRSTGRLSLTRNHQGDIISVVTPSFRTPLVQFPLDVSRRNAAWWRLDQKILKKLMGLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMW5</accession>
    <name>A0AAD2JMW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS20605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="151"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1964383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="299" mass="32601" checksum="79146F8C7594F65D" modified="2024-05-29" version="1">MIPSTSNQPYRSDWYSFFLLSTRSQKAQGIMRCISILLCAGSIPAINAFTASQSASVRQFSLFSQSSSSSSQMVDESSSSSSEASPSQGRREFVASSIGLAALGALPTLSQAADEAIPEGGGVTMFKTGSGLKYIEMEQKGDSSRPSPKYGQLVMIKYDAYMKLPNKGKKEKYDSSDGYVIKHGNGRMIPGLDEGLHTMKKGDTRRLIIPPKLGYIDNNLGPLPDNPFNRAKLNRLLDQMIAQQGGQLVFDVTLLNFFDDEADQGYYEDADPTPHELDQIFNRLAKGGAGLNIPQIETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN24</accession>
    <name>A0AAD2JN24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="350"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="456" mass="51833" checksum="1CD715063ED5C3BE" modified="2024-05-29" version="1">MSINDLEIEDTPDFSALADEDIDTIIKDLTSRVNSISFQEREVGLHDIHGVAGIDDKSNHEEQVLVNTMRLLLSERLHCRSSSAFRMADAESSAYTRDNSFLLMFLRCENYNIDTATNRLFEFFKHKLRLFIGPDKIGKKMITLADLSPNDMKSYSAGFFQLLPHRDHVGRAQFVNLPNYTTWDQRENVLRMIFHLCMAALMDEETQKKGAITVVHSLVSETSELRNPKGYDPVLTWQSTHLLQKAIPLRFVGTHICTNPSSFSGKFFSSMARFVGDAGIVRIRFHQVSFNEVNERLSTFGINSILLAVSQSGEKKTEKHRELMKVIKSIEVAKLLTPEKLTVLVPSATDVLLGRGKPIQNHVGNIRLGLIVESQLEEYDEIANRLDKTRLAEITMAKMKDAGVRFLSRDDNGFWELATEQLARERVSSTFRTVRDRLKGSQRCTNVPKRSLENAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN63</accession>
    <name>A0AAD2JN63_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042220094" evidence="1">
        <location>
            <begin position="26"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="393" mass="43997" checksum="DCC1F6FE1FDCEEF8" modified="2024-05-29" version="1">MPRMLAISLWIPLLCILNSFSIADASIGPIDRRSQLFRNNKSHSSNNIPFVVAAPKDIPESSASSETSKSKIDATLTKYHHHVPRGGQDKIDGVIRVVGTVTQTLISCGRAILPPIFACVKGIVNFYRALPIDAVIAQVGLVYCFAGGYYPTLFSSLEAARHCGWEIAVEAVKDLTDEAIKVIDATADLPRDAFERKEIFLQQTNIVLKTVDPMKINQAAAALYTTWLGISTVLEKEYARVINLSMTLAGFFERIAHFILEPPVKMCISQDYHKWVPVVIGWIAKAAAMNIAWRIQRVLTASTSAMVGGVMFARALFRMISRKGFRLFGLIREDDTESPLDEIVGFTVGGFGFWTQIQTQYKNGFTFEVPFPFNLITWPMDWAERWIQWQITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNG1</accession>
    <name>A0AAD2JNG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042262893" description="Subtilisin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="64587" checksum="7E4C3417C3C6CFE8" modified="2024-05-29" version="1">MMTKAHCMGLFLFSNLSLGSAGTSKDVLKSILKERREIQNNNNHDPIPDRTGTSMHQPEARRQLQTAGDLVCNRFVNGRDRATVCQDDATFSYCFVDNPDQCEYIAIDWDLFEQRKEEYTGPVQGDLDLFIAETFFTCACDGYIPNCATSTFSAHSINACREDAANFVSCEVEDGIEKCSGRNDGRSYRCTRSPSSTAGVETITCCTIATELEPQTCVRSVLNFDPNASSSLRSCQVDVDGDACTCSVCGSQPNAISYDCSAVGRDDLVESCPSGGTLSIEEFFLAKLDNPLGYIEPLGPVVTDVPSASPSVNITPMPSAEPSGSASPSLSQRPTTLNTPSPTTSPAPSGSPTTSPPTKAPTMNPSRIPSAAPSVTQVPSSSPTKSAPPTIFPTRSPSITPSLTPSGSPTAPTPGPTATVSSSPTPDFVATCEGIHLQIQVFNEGYGDLECGDYEGNFPGAIYACSVTTSLRNDAVGFDIEPSSNVRQPFHRRCNATAPDGLTLFCLDNVGANFDTFKSETSDVDLGCEASYVFPQYNLLQGVSADTKESDSFDDALAANAYFVEFLGDPTAPSTSSKGLDSAAPSRNAVSVSCVLASSFLVYFLSSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP56</accession>
    <name>A0AAD2JP56_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS23478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002413">
        <property type="protein sequence ID" value="CAJ1968954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP56"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="575"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1968954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="640" mass="70128" checksum="B4DBF64A09CEDC40" modified="2024-05-29" version="1">MTSALHLGLREMVGRALIVAAGGGSVSLTRELLDNGAEIDEVDPDREQTALQVACSQNQIEIAQLLLDRGADIDCKGKREMTALHMSCTTENVDSIRLLLDRGANVEATTLEGLKALHIACVKGLTEIVGILLDRGADVNSRHDRLSLLHIACVKGYSEIVGMLLDRGADINSRQDGLSSLHIAYHKSHWDVFELLLDRGADTEVWTDDDVLTPLHVASTHGNLEAMRMLLDHGADTESIANNCTPLTISCFHNRLEAVRLLLERGANLEAAYQENQSPLHVACARNQVAVARLLLDHGADIESTIGDGCSTPLILATSSGHIELAELLLERGANIEAKAEHNATALLLACTNDNIEIVQLLLDRGANMSIQENTTSPLHLAVARGSMEITQLLLDRGCDLEAKSKNDNEDTPLHTVCAFGNLDIARLLLDRGADLGAKNNEGWTPMHLACKWKNVHIVRLLLDHGADIEAKTSQGMTPLHISCIDDLRMTVRLLLNRGANVEAMNNDQITPLHASCKCGRLEIAQFLLNYHHADIEAKAKDKSTPLHVACRFGRLEVVRLLLNHHADIEAKSSDESTPLHSACRFGRLEVARLLLDRGANFNAKTTKKKTPLHLAGQFRHSELVWLLVHRSPMQVVEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP81</accession>
    <name>A0AAD2JP81_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="131" mass="14016" checksum="83599872C287EB8E" modified="2024-05-29" version="1">MGDDEVETGHSRYCHHPTMSNTRMIVMEYDDEDEDPSPVKSTVSKGRPTNSPSSSDGTSPRAEAAALAGLQAATATMERGADQKQKPSFAEAHCSESGGPCDTDTDCCETLGCSQMGDNEVETGNNYCYCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPH7</accession>
    <name>A0AAD2JPH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protease Do-like PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS24026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002447">
        <property type="protein sequence ID" value="CAJ1970002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPH7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041517">
        <property type="entry name" value="DEGP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046449">
        <property type="entry name" value="DEGP_PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45980:SF9">
        <property type="entry name" value="PROTEASE DO-LIKE 10, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17815">
        <property type="entry name" value="PDZ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Protease Do-like PDZ" evidence="7">
        <location>
            <begin position="511"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1970002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="667" mass="75396" checksum="F8F470B00E1DEA25" modified="2024-05-29" version="1">MRYCEFRAFEFRIKYKKPRRQQLHHLSTLLSLIGFIVPFSSTFQIPSVYPSRQTQYRPFQEAQVQFKRSSSHKPKGLFSSSDISDFIESDSILGDEDEDEEYDPIMSLFWPSRRDPNQADGDIETEDEERIQHQQNQNRIFDSIIKVYATHKEPDLIMPWQSKHPVTSTSSGFVIEGNRIMTNAHSVEYATMVQVQKRGDPTKYLAVVEEIANECDLAILNVLEEVVDDDDEEFNLSMEIESQGGTSGDEEMKNGESNGIENQEPVEKSHHKEFWAGLDDQPLQFGSLPELQQEVEVIGYPQGGNGLSITSGVVSRVELQEYAQSGMHLLAIQIDAAINSGNSGGPVVNDEGQIVGVAFQSLDQAENIGYVVPVTIVQHVLEDVRRNGKYTGFCRLGTQSAYLENPSIREYLKLPKRFRGAGMMVRECYPTCFAKDYLKPNDVIISVDGIPVAQNGNIPFRQGERVSLTSYIQTKFIGDKLDLEVWRKDGETKKSSLQNIEVPVSPNVSLVPQHWNNKFPPYLIMAGFVFAPLSIPYLEACDAWGDYISASISNLLGFVRKPQQEEGEEVVILVQVLAHPLNLGYDQLCDIQLSTFNNVKVKSLKHLNELIEECRKEPANDDNEFITLEFGQKGNLVILKRSAIPSATRQICKQFSIKKPYFDARMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVK8</accession>
    <name>A0AAD2PVK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1955924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="584" mass="65050" checksum="7AF8BD86FCDBC37D" modified="2024-05-29" version="1">MEYASDDGDDISKDSAEELLKDGNENGAEHSTIFRLQTDSDAIPSGPNETYISLIIHEPVTRIPFDAFRSWSRLESVVISSLVMDVGMSAFAECNCLKEVEMMSCTMVRIGASAFDGCPSLQTVRFYETCSLVELRDRTFKNCTALKELQLPAGLKTIMDHCFLNCTSLGQMDLPKGLVELGGSSFMGCTTLKGIDIPGSVVRICELTFCGCCSLKSVNLQEGLLSISSSAFSFCLALESVQFPSTLFSIGSNSFASCTSLVMIELPIYLRRIDDRVFSACSNLKRVWAPPFLESIGHRAFQSCSILVSIEIRQDGNLSSIRTSAMEGCTNLRNIALPPTANPSELTFSHCHEMIKRTKNMDLLEALQNRFEGLTVHDICYHGGKDLTVARLEDALNADSNESFLRRDKLGLNLLQILLLSFNPKRGILIFLARKYPSFVIPDSFGIRLTIDAAVQRVIDDLCYLDSLSTMQDILDVSLYHRVKMLGAQTWKNTIYNLVGSLSIAHDFWTRKDGILRILSKLESYERLETTSLLELAVWKSALVLGWKDPKKLTTRERNGIRVTNGSNVIIPQVARFFWDVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWV4</accession>
    <name>A0AAD2PWV4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002133">
        <property type="protein sequence ID" value="CAJ1963123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWV4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="13517" checksum="C7A60A08E11F482D" modified="2024-05-29" version="1">MMQVPLGMQLMQIPTQGGGTVTVPYSMNANGEIAFSGMQLGHQGFSGAQVRQGFDATQAQTPQIMKTGYYDTSIVFHDAIKGKDENGNDVYLIPCPTGTTNVELQADWHYASENEDLPDLATEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX06</accession>
    <name>A0AAD2PX06_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002167">
        <property type="protein sequence ID" value="CAJ1963910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="171" mass="19173" checksum="FA1ED29FA9C7F5F9" modified="2024-05-29" version="1">MKYAIRSGLTKNCPITEEAINHAKAIFGPDASTLKGKSTRPTPKKTYDDFFNPPEELYQHNRSITICIDHMEIENAKFLTCIDTTVRYGSCIPVQNLKTDPVFALDKIFRCYNKAGFQVKIIKCDWAFIPLMDGMLDNMGVTTDPTAAGDHEPTAERNNGTLKERVRVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXU5</accession>
    <name>A0AAD2PXU5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1968028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="48840" checksum="61D7CD3CCABE63F5" modified="2024-05-29" version="1">MTEQEEIENYDNFSVPSFGTTEREQQKFGEEQRNICYNRFPRFLFILIVYFIMLVGWAINCYWQRTGTFVCDTIFVQFNDIYHPGLATFSGLYDSRCGEGDDTFCERATYVESGHGSRFFFCEDISAWVFAFDEDGQFNCANWITGSPETDVLAETSYNIMESVKGSETWSIKVGDRRQLPVPHFTLECYDCKYDENFCGGGARGKCVNNRCACEGGWYGYRCDYFMPCEKLEVDPLHNVGGSRTWAGTYQMIVAPTESDGEDDEESTTLQSMMANSILSLGRTFLPIVIFTSSDYISPSCQGVKVCISSSSSWYDVVADIFPPESVVGTEGITGSVPALGEGLCNVFGATRFEVVQENVERLGYNSSFLGYALGSRMHSKSFETWMTRSSDRQWTKMTSWIFEALVEAEESGITPAQRRIDEINKRLQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAF3</accession>
    <name>A0AAD2CAF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1901775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="115"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1901775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="304" mass="33273" checksum="60E973BA02749962" modified="2024-05-29" version="1">MNSYQNTDAVRENAIENDGIMNTNGEGETTNEYVLGVAFWTFVLFMATEAVFAVIAGSQAMLTDALAMSVDALTYLFNLVAERVKHRPISDKEKLLPTNVFEYRRERLRLYLELVPPLVSVVTLIYVTVGATQEASASLMDRSQDNEDVSVGLMFWFSLANLFLDFLNVACFAKAHQAYGMMSTVRKESAAFSSPKANRMTEQQRLLGSKKSDENDNENDFVVNLNMCSAWTHIMADTLRSAAVLIAAAIAVCVKSVTGSIADSVATIVVSVIILISLLPLLRGLVITGKKIIALKAPTPTIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDJ4</accession>
    <name>A0AAD2CDJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1924341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="56807" checksum="5485A2FF901673DD" modified="2024-05-29" version="1">MPPKKKARLKLEQNSVFVVTAATTKDQIPNDVTIVRVDESVRVLPDGIFEYCIALEEVTFEEGAQIIGANAFACCKALAKVKLPSTLRKILNMAFHLCLGLCTIDLPLGLKVIRGHAFTGAGLRHLEIPATVETIGPAAFKYCRQLESLILPPKLEVIEFELFFMCTELKEMKIPRTVKVIGSGAFASCSALTHIRVSPNVTSIGCREESTNSVFGGCASLRSLELPEGLETIELLPFADEDLHPFADEELEDILGWSSLVNLYLPPTQTVHDRFLNKAIPQTFQLAKVAQNWEDLATKLQNRFDGLPLHRVCYFQSYHLVEDTIQQISDILSDNPSALFETDAFGMTPLHIVALAQTPRLELLQHLASGFDVPRTKDLFGSTVLEYISKNPFEEGRHATRWLVNLLVGQRLSVLGLDRWKQELLAMKEGVLKADCASTMSRKVQSLLDGLVNLEFLEVLSLIEMVLWRIKLGENASDQGGIDRESCRVHCGISILIGNILPFLGKDNKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEB6</accession>
    <name>A0AAD2CEB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS2566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000180">
        <property type="protein sequence ID" value="CAJ1931830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="55"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1931830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="580" mass="64935" checksum="AC51D84E8B9592E0" modified="2024-05-29" version="1">MSKRQLLQNPGGSSKKPRNEENKKSSSAQKREMKKDRQSNRRHSEAVVEAKGLWNKLRLKSNTPEEIKGLMQQVMTLIQGKVNEISLQHDASRVVQAAVQFGSDRQRKELLLEILQKGDCLPELSKIQYAHFLALKFIKYCAKDRECVKMIVKTFKGHIPKLAVHAVGSRVVESIFVNFPPKETAILKQEFYGPHFSLFAGGFKEVPTLKSNLESATTENQKDSAMTFVKEIISKGISKSFFGYTFFQGLLAELMDVSEPGDIQEMAPALADHSIHLLSTRAGARVVASIASYGTPKDRKRVCKSLKGYTASSLMHRDAYLALIRLVQVTDDTVSIQKSILNEILASQQKGKEEETGEQVLVDLASSDTASKFFLFLLAPDSESRMKYFDPYERSILEPIPEINGVCTYKKEPGARRHELLKHMKQQLVDMCIANANNLLDSIPGSRLLKEVYNNFGTQELVDAIMEICESAINKEAPDDELSVFEDPNRHRAIKNLIVCDSTRDDPIFATAFFERLQGDLMKVASSNRGAFIVASLFNVKPIRPKLVNVLKSQQQMISNLSSNGKAKAGYNALLKELSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF46</accession>
    <name>A0AAD2CF46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS851</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1919533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052454">
        <property type="entry name" value="TMX_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107">
        <property type="entry name" value="DUMPY: SHORTER THAN WILD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042080134" description="Thioredoxin domain-containing protein" evidence="13">
        <location>
            <begin position="29"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1919533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="25766" checksum="3C2126210EC23B00" modified="2024-05-29" version="1">MLVACRFNFASLVTVSLLLLSRIFTVSTESVKTTNEGGTSGNANAVGRRPIQLTSRDFSKYTGDGNVWLIEFYTPWCTHCQEFSKPYANIASAFHSSPEEKIRVGKVDCSEEKSLMNRFHVTGFPTLFVVDGYSVYEFNGKRSEANLMNFVRGGYKKEEAIPFIVSPMGPMGQLQQLLVHLGHMFVDTFRWVQSLSGMSPIMTGMIVCTFGVFWGMAGIILLTILTKPKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFM0</accession>
    <name>A0AAD2CFM0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000268">
        <property type="protein sequence ID" value="CAJ1933357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="254" mass="29027" checksum="22680E8D206CDC1C" modified="2024-05-29" version="1" fragment="single">MTRIFGSSQSGGARWRIVFHRMSNCSHNVITLDRKAKRSKADPDAIMIESGVKASSSSTSNEDMDMANSEHGNEEEKESTAYEMLVKDSLLQQWSEDYDETLEEYLTIIGKAKEFPDAQAVNFRQEVICDAVLAAFQGNQEMISEAKIAMKTTSALTITSLNFLKHQQERLKIENERGLDYFLHTVCMEVLKEYYKRTKEQARLLTVLSESNNRMVPVNYLISKTELSHSYDVHKFVLQAERVAKWFDASNDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGQ0</accession>
    <name>A0AAD2CGQ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000288">
        <property type="protein sequence ID" value="CAJ1933616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="477" mass="52495" checksum="935C57EB71AD27AE" modified="2024-05-29" version="1">MPSQDPSTTLLTQEELQEDLQISVAAAQEWPAELLFTGLVGHENESLDLFSFVTNGMERTLSQFNPDHWPPNKEGQKKLLEHLQQLAMKHGTHFHLNSHAGTLRCSRTRKARATHTAKDTTGDKLCNCRLHLKISKNKEFIYLSCKGEKMHKHHPRPGALPAWANNLTDKQRHHLLVLAQQRAAVANPQSRKIMLELKLGYISKLAYRTVLVTAPDYIAAKAVAGANSSAAQFISWLRAQAGNPKSKLSYVVLSYALTTKNCNIVRDHIGNPKGRRSKSFPSPDPEMVMNNLAYIDKVVLPAPHADKHNSKPTPPIGEGGLVAKSNLRKAAIARLAKPRWEKYAAKFDAEYHLKNAEAIRLEKEAIFCRPAKEVDNETITNNLTYTSSVAVLSNDASEKKFSSGDDGSVMMLDEPDKVQALDVSDDSDLESTSDNEGSHVGGGCKKDDTGTKGGCKQKQAPLPMGLFFIPLVASVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGW8</accession>
    <name>A0AAD2CGW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TAZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1914436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAZ-type" evidence="5">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1914436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="363" mass="39964" checksum="9D5C9E99B864B7DE" modified="2024-05-29" version="1">MEQSGNEGAPSSDRQYENSPNHVALNGVADAQNSIISALPPPMPSRKLGEQPPVVNNVELVITKAKKAATYLYTLLHAKNCRLSADRCLHPGCAEAKLMYLHLKTCGAEGISCCSTEYKGCVDARKLLLHYRRCRDIRSRKASGQGSSEPHFCLVCSLVARNAKSKGRSLSPNSTNAPKQPRKQLMPSAGVRCTPVSQPQKQQLYKQELRVRPRSFSFSDIGRSSIKPTVPRELVKTMPPPPPRFSVPSLPGRASNAVPGGFQKTMSSALAVTRSPEHRDQLSNNARPRAESLDLRRARFLEPPASNEEPLNHQPTVGKVRFHVRRRSASFDALSSSVKANEFPTIEEEPVGEDLQEMLEGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHB5</accession>
    <name>A0AAD2CHB5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000358">
        <property type="protein sequence ID" value="CAJ1934689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHB5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="100" mass="11085" checksum="91E7FA8052BCDE52" modified="2024-05-29" version="1">MRYKAKRSEAVYLIKHFLEEPKENLSMPESFLTRGSWASFLGSIQEEEQSTQSGRSAGGNSDNAESSNLDDVHHVEHDLNNRSSGALKSANTTDKQSKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CII0</accession>
    <name>A0AAD2CII0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000091">
        <property type="protein sequence ID" value="CAJ1929780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CII0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="167" mass="18652" checksum="8A642268B9A2514A" modified="2024-05-29" version="1">MSYVLLLRRGKNTKILCRGPLSRLQNPPSRSSVKVTKNPPSRSSVEVNKILRQGPPSRLPKSSVKVLRRGYQKSSVEVLRRGYQKSSVEVTKNPPSRSSVKRGPPSRLHIILRRGPPSRLRNPPSSSSVDFNNTSSVKVPRRGYKILCRGPPTRLQNPPSRSSVEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ42</accession>
    <name>A0AAD2CJ42_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS2183</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1930983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF71">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1930983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="79217" checksum="5CF04E34193AACAF" modified="2024-05-29" version="1">MNNHDEENHYNRDDDDDDDDVHDQLPSVEEYKASVGPGNGKIDPKRIMESIQPDSDEEDFIHNVDDNEDFILQPPDDIEDDDDDDYYNDDGSDDQVIHDQLPTVDEIHAQRQTQKGSGFCSGRRWGYCIMTLLFLCIVIIPPVLLTRKDHYEERKEQIVEFLMAKQIAKGSQLDDAQSPQAKAVEFLASEKFDNAALSEEKLIERYVMTVWYYSTNGTKWRYPMRFLTNEDTCGWFAWFRNQRSGQITKEGVICDTPEGSSTPVIGLLDMPSNLLQGTIPSELQYLSNSLEQMHVEFNPGLEGEIPIAMAQLTKLWSLELQYCAINGTLPEWLGTDLPLRRLGLSNNLLTGSIPASILHQTNLQILALDDNGLTGNIADFGPLIKIQYLYMEDNLIDGQLTNQILTNWTALKEMDFSRNDISGNLPSDLFTKMTNLEILDLHGNDITGPLPSTIGDNNRIVFMALQDNKLNGPIPAGMSNMIDLQHLDVSRNQLSGKIPPEMGNLSFLRYLFLGSNSYDAQVLPTELAQLTLLRELSIKKANLQGELPTWIANFTQLQLLDLDQNDLQGTIPNEFGVALKSLDHLMLNRNALNGTIPDSFALLTDLNLLLLDHNALTGSADVVCSIPDLRLYVTDCEAVPTNDPGVFEAAEIECSCCSTCCHEQNATCNMYDWNVNLDPIWEYGYTRYVYTFSQNLVEKDSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJR6</accession>
    <name>A0AAD2CJR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Transaldolase</fullName>
            <ecNumber evidence="4 10">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS5100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000002">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1936255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="314" mass="34185" checksum="6A0240B951ED1E56" modified="2024-05-29" version="1">MATQLDQLKEHTIVVADSGEVDAIRRLKPQDATTNPSLIYKAAGMDSYAKMIDDAVSSSNGDVSLAMDKVAVNFGIEITKIVPGYVSTEVDARLSFDTDATIAKARQIIELYKEAGVDKSRILIKIAATWEGIKAAEILEKEGITCNLTLIFSIAQAIACADAGVTLISPFVGRIMDWHKKEDGVDGYPGPEDPGVKSVTTIYNYYKKFGHDTIIMGASFRNPDEIVELAGCDRLTISPALLDKLADSTEPLTIKLDASKAASMDIEKIDIDEKSFRWMLNEDPMATEKLAQGIRGFTADTIKLESIVKSKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJW7</accession>
    <name>A0AAD2CJW7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000569">
        <property type="protein sequence ID" value="CAJ1936891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJW7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="542" mass="61764" checksum="C99F780CF113DCA6" modified="2024-05-29" version="1">MSIWKNSRHRKQHSDESSSTSTARYFFTPSKKIRLILFLASVGVLLFTVELQRKLFQTALNDENTQSWWSLSFVTPSAVYYPSSAAAAVFGKGYPNRRQKLSSSSSLLLTNESWNEWEHKFRANHTMLLEQLQKSSVYGSTYDDDHDHDGIVDVKCSVDYLRDYVQVTRPATDLSPLPNDCDWPKRLKQQQQQQQQWKNGNSQSPVPVLLSDATIDATIDADSNDNKCQLVHFSATQACQLLNERRAAVNHDHTKNHGQQPQQQQPIVLLFIGDSLIRHIVIGLGIVLTGNVRQGGVQYIHSNPHDDLGHVWKRACSCENQFTCATLKQQDDMGRFTHAFGYNNMTYLNHVDWCQKSNNIGIDTRQHPPRTYQIILEQQNNNPKISPMVRQLIANHAKYHSAFVIVTDASALHSGLNIRKTRRFLDKLENLLRLQSSSRSSWLIIPMTVHHVGANKPNEFLEQQGRQPVEDYNQQLRTWVEQKKTNYRLLDTYSMTQGLPSNDGTHYPSASVALAQILLLYLRDYLPATVVRDGGAAAVQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK39</accession>
    <name>A0AAD2CK39_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042100750" evidence="4">
        <location>
            <begin position="24"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1936613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="427" mass="47600" checksum="7E457359C41EACB3" modified="2024-05-29" version="1">MMLHQSVLLLTAIVATLVCTSQASSNYGVDCSWPIHSKNLTCGNLLGDRKAIYEDYMEGCREHWGEKGRKRCNAAEADRLEMSRKQPQSMVNFTSTGFKKLKAPAKLWELLSEFWEENEDEQEIEEWFVGNVYTNNWAAPSYYIGVEDTELEGGGPDLRNEIWEAARPVLEEWTGRKLQPTSQYGIRIYTEGAILAPHVDRLPLVSSCIINVAQDVDEDWILEVYDRNDNAVNVTMEPGDMVLYESGSLMHGRPFALKGRYFANIFIHFEPTGEDLDGNAGRNEVVDDDFYPPYLLPNSPWLETWAQQNPSGWRRTSPSAASVGVPKAHAAAASGDVDALERLAFDDKESLSACDANGWTPLHEAARAGHLEVVQMLVEKQQVDINSLTNKGKGSSAYFIASQSHSPDHPVAKYLQSLGAINQGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKV3</accession>
    <name>A0AAD2CKV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000469">
        <property type="protein sequence ID" value="CAJ1935395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="256"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="491" mass="55844" checksum="347570095ECCCFE0" modified="2024-05-29" version="1">MTANDMLQGKEIALKKRFERDFLPKYGALWRCIEQTRTAPKDPQAPVKACVDFLTAIENKAPATIRAATNEDECGCECEPPILENENGKENIRSLPNFEMQERAEEKTDANESQIIHLTEDSDSDSDSDSDSDSENEIELETEPPIGNSKVVEILTDSDDDTSDLRKTARLDPSRRPLQISSSFIDDDSTGSDSSSDAEFEIDFSNLSEEESNDVDDLIESTKRLSVNDKDNKRTFSQPKRKRTPMSKRAFKTKREPMTKDLFKEFNTKVFGGKLESVSVQWSTKLRTTAGLTRLRKSGQNMRPGVPLQRFATIELSTKVLDSQERLESTLLHEMVHAAAWILDNQCNPPHGKYFWKWARIAMKEISGIEVTTTHTYEIEYKYAWACSKPGCSFLVKRQSRSIDVKKQCCGRCKGRLVEVDAKTAKTNITEKKRAPPSEYNLFVKDQSKVVREKLMNIQRGEGRANPKVSQSDVMKECARLWREKKAVQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL98</accession>
    <name>A0AAD2CL98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000282">
        <property type="protein sequence ID" value="CAJ1933595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="412"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="638" mass="72735" checksum="E67D7D361CA1B008" modified="2024-05-29" version="1">MNVTVNYSKYSDGRVPLEIITGITPEITEYLDFTIYGWVFFRSDGGLGVNHIGRWLGVSHRVGPMMTYWVLPKSGIPISVDTVQMVTNAEQQTDSVKQQMQRWTADVSKTVDAKSTYINWGKEDIPHQMMFDFDDEDDKFMRNFGMLINPETLEDGDFEGTEEAADDLDAQDYTNMEIGLRRGAEGELQRAKVKRRIVDENGRPIDVASSNQLLNTRQYEVEYADGGTEIFAANILAENLLAQVDEHGHKHRLMEEISDHRKNAKAITKSAGSMLLPSGGTRKRQTTAGWELHVILKDGSSNWVTLKDMKESFPLEVADYAKLKAIEDEPAFAWWVPHVHKKRDRFISKVKSKYWERTHKYGIRIPKSVKEAIQIDRENGDTLWQDAIKMEMKNNRVAFEEFGGDIKKVIGYKRITGHMVFDVKLGENFRRKAQYCADGHKTEAPAALTYNTVVARDSVPILLTIAALNGLDVQCADIQNAFLTAPNLEKCYMITGPEFGDEEGKTFIVRRALYGLKSAALAFRSHLAETLENLGFYSSYADPDVWMRAAIKPDGEEYYEYILCYVDDILCMSENAKDVMEQISYKFKFKKDKIEQPESYKIEQPESYLGAGVKRKVLDGQHMWTIRGGTYQRKPSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLD4</accession>
    <name>A0AAD2CLD4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000671">
        <property type="protein sequence ID" value="CAJ1938146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLD4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="17323" checksum="7EB5135B85B05711" modified="2024-05-29" version="1" fragment="single">MKDSIINPPEKDPNSIMTVADQGQGGLEEKTRSNSTTQSSIALTKDNPAITTPKHISKRNPSKTAKDGAMKGRSLLPSEVAQGQFGLSAKARSNTSPLSIDLTKDNPDPTITKSQRKQPPPLPKPPRMAQCKDGRSLPTTRTSRCPSSTGSTRRRGGKRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLK1</accession>
    <name>A0AAD2CLK1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000699">
        <property type="protein sequence ID" value="CAJ1938274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="489" mass="54377" checksum="6FB8BC9ACF7A3D28" modified="2024-05-29" version="1" fragment="single">GSSTTSRRYAPSPSHPSCPWWTAPLPPDVLCATVCPITGSGSVLLTGTGRASEPAPTTSPSILQAWQTAAELRTDYYGWVPDEIEVHGNEATLVTALVEGRLRVISDGSFKNGLGTAAVQLLVRIACDGLSATEMAFEDRQLSPTDAQFDLVSPIREAILRSSVDWLPQHVYGHLNKSNLFDKLSWWEKRNLEVDGMMVEYRKELEAANHLIAPNPRFFTKLAALYVADTKQSRLDPQFIQECVTLPALRLRWRDKGTISEAESEVALDPLGRAMRSLPAGLQRWSTKHCVGMCGTGKFKVLWGLETSAACPRCGDFEDHLHVPRCRAALATAEWDRRTAAFSAWLDLQLTGPSIKKSILQLLHGVCAPTSPSPRTISPSVRPAFLAQQVIESQGLLEGLIASSWLPLQQQHYDKIRCRRSVSLWASRLSQQLFSIGFYMWEQRNSVQHSDDNVQLRERHSTVNEGIHSQFDMGPDDLPKEIQPMLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLX8</accession>
    <name>A0AAD2CLX8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000778">
        <property type="protein sequence ID" value="CAJ1938823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLX8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="119" mass="13259" checksum="7B777BC576B4802E" modified="2024-05-29" version="1">MMALWAKKLSIGLDDDKPVACLMSARTEIQLYLHGKKGGENERRAESQEGQEPTVAMELTHRGGLSSTQEAWTKEGAVAALDPTSAAPWRPFRFSRPRRQLERLLFVISRPVVVGRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM63</accession>
    <name>A0AAD2CM63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000021">
        <property type="protein sequence ID" value="CAJ1927590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1927590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28338" checksum="5213C55259C8B53E" modified="2024-05-29" version="1">MLSEFPVKFKDNEIQETPAGNNLLEKGKGAPLEKERREVFNWFVAKSLFLSKLAPLDISPTVSILASSVQSPNLSDWQKLVGLMRYIHSTKGWHLTLSADDLHVIKWYVDAPFAVHPDFKSHTGAVMTMGTGAVQAITRKQKLNCDSSTHAELIGVHDAMSNILWTRLFMEEQGYPIEKNILYQDNKSLILLETNGRSSAGKRSLAINIRYFFVTDQVELGNITIDHMPTDEMWADYMTKLLQGKKFCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMK4</accession>
    <name>A0AAD2CMK4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="811" mass="91136" checksum="B81D9D0D944BDC83" modified="2024-05-29" version="1">MAPRPEAGRHDVFPHQSTAYNDDCTVKEIQLDALEHTLDEFSKLLLLKEPPLEETTKEARVIKEEIVQSSTSEDRESISNLFAEEENALDDILNEFMTLVREEAEEEERDDRKSECHLKVDNKESRIRPPVSEEYITSASARSVGGDDENDVGPFTTGLVESHGPLLLVESSKKPLDVIFLEGTEAKNDQYALQSSKSIDSICTMDLPLHSKNEAEESVFFSNFWQCDAMTPLHTLLETNEAAQIKDDDSLSSLRRRYKKETVPQAILNIMLIRREPLEIDFPMLLQQLEEGVNDGSSSAENADKHSSYFSYMYNLVTSTPPLVLTQATTEVMDGPKTSEEGSTANEAIECRKQVNEISVSLTNASTSELLETRQIMQTASVGHEPSDQQFEDRNDCIHTEAHLEHDPNLCTTEEECREEIEITRYDDDHSQEVSRDKPESLVKIPLPTISSPLEHELTKFTQCIIDAPISEDTSTSSTDDNYQQLPYPIFTKFDLDDDDGEIPVDDDAEYFETMETPRVRNCRNHDAKSTAFTSVGSNVWGQWPFFSKYGDPEEMVLQPLHPQQDKPSGFILQQDTDLSTLSGSFSLSEFAASDSPYLMRLLNRNDHSNGEAAADYAWFQTSLDNQERIDASTGDKCDDSHYFDQSWGLEQLEHAYDEFAEDHRNDMIRYSRNKYHRESLNGENTKGGRLESPKNNAAGAFSFEGAFETRDSTLPNDIVIHKEIADGLSFSVSTVSNGSNFCGGNSWGKKRDYPTIPSNNKNIVNKILLENCPSDATEQVSYSSGSLLHKVNSIVDASKGLLNQILVGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMN6</accession>
    <name>A0AAD2CMN6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000413">
        <property type="protein sequence ID" value="CAJ1934905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="111" mass="12378" checksum="5F3FC9C33C98C618" modified="2024-05-29" version="1">MGRLSYGGGRGHVTHQKVKDNPISKVVKHLFSTKDVNNEKARLLFKDAEERLIDDVQASGIKSSEDMVKSIQDGKSINFDSSTPKLDAPVARETEMTQNKILYSAKLNENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNJ8</accession>
    <name>A0AAD2CNJ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000968">
        <property type="protein sequence ID" value="CAJ1940866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="455" mass="51271" checksum="84F20A29C9902566" modified="2024-05-29" version="1">MNLDNSQLTQYLIAAFDTETMEVNPLEEIWSLRILAMQISLQNPFSFFGIDEFEGKPDDNHFFSGEMPNPRLRWEHPLVGFWFICSELFDYPWINEFLLEYYDDPPSAIVDAIKQTRSGKSINKAPNQDSVKEPDPPCVQKIYNPMYSIDEPGTDAQRDSTSSEGDQVQNSNRFAPLQSDNDSFDGSGIQEFDEVEVVAVKKNDSKAPESSDEDEDADADDTDDRENIVDNAMEEDDDDERINTAGVNLHDEAMDDNTLPLTSPKLTSTQDSAGAGTLMEPSETTPSRIQRPPTLAKRISNLIQVNMEGIPGKCHIFETTFSMDYQGSDSGTVAEALLSTVLNSMEEAINNSPNELKLLPISDTTYKQPNLWIRNSVDLRNRILTYRALSTYCDMEYGNCPYAATNSKPGEKKLPTRLCVWRFRSRPSKTTFIADYVNWAEALGATLFHCSMEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPA7</accession>
    <name>A0AAD2CPA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS6233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000756">
        <property type="protein sequence ID" value="CAJ1938684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="237"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1938684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="581" mass="66370" checksum="0F4056982913B747" modified="2024-05-29" version="1" fragment="single">MAKETLLHYPDFNKPFEIHTDASKYQIGAVITQDSKPIAFYSRKLRDGQHNYTTTERELLAIVETLKEFQTILLGHKIKVYTDHKNLTLTQFNTERVLRWHMVLEEYGPEHIYIKGPDNIVADALSRLDLIDEEDDDSSPSSPTLKIMAHNDGERSSEPSIPKTKNALKADDVTLNDYMNIRRDELPDDIYPLCMSLISAEQQKESELQAALNKPNSQYTRTEVRGGNTRYDIIYQNEVIPWDTLCIDLIGPYVIKEQGKRKWELHCLTMIDPATGWFKIAEIPDKRADTVSNKLEQTWLVRYPWPQHVILDRGSEFMAEVHEMLKNDYGCTVNQTTTRNPQANAIVERVHQIIGNMIRTFFVDDTELGEKDPYTGILSAVALATRATIYTTLNTTPSQLVFGRDAMLDIEFHADWNAIKNRKQKRINENNLQENAKRILHNYQVGDQINGYAGLRMTAKMATVQKNKEGFTPRQVKAAMEARSAMHILNAPSTKSLKYAIRSGLIKNFPITEEAINHAKAIFGPDASTLKGKSTRPTPKKTHNDFFSPPEELYQHNRTITVCIDHMEIGDAKFLTCIDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ61</accession>
    <name>A0AAD2CQ61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS7890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042107134" description="ATP-dependent RNA helicase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="164"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="482"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="681"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1942324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="715" mass="78446" checksum="0CF375F7CBE651BF" modified="2024-05-29" version="1">MTATTTRAIGFAACLALCSTFTPSPLQQQQHHIVNQQPRQYAPSVLSMSGDDSAEGGLMGLNELQTLLRDAVRKEDYIEAGSLSNQLFDRLYSDNMPTSDEDKKSKRRRMSWKGLGAAPWLVDRLDSLNFTFPTTIQINAMESVNEILNSTDEMVESSSLEERIGMNDKDLGIVISGSTGSGKTLAYLIPLLSTLSDSLFTRQRIRVGAEENVGDTTGDMLERISVVTSPVVRTSSRKPVRGGAIATGASLATLGKSGKDVKSPLALVVVPTKELGVQTAMILYELIGGNIKKDAAEMKGKANMFKYKGPKGVRIGCVLDEQEAEFGLKLQTDVAVTMPEYLDKLIGDGDLVPSKLRVVVYDEADLALENTAADALKSLFDDNLEEREYTRLTFMVGASVTESLGSLAVRNRILPEGKSFIATALKHRPLLDSADLEAETKASSEGSGKEPKTASLQDLNLCLNPGLIHQRVRVEGKNGLLALTRLIRKELRDYDTGKNSERPRVVIFFPDEVIAKASIAPLRDALWGEHKLCVLLPKTGFNPLQMMEQFKSNETSVLLATPNSVRGLDFPDVTHVYTLYLPMDDPREYVHLAGRVGRVGQKGSVRGSGGRVVSILQEEEADKMEQLAAELGFDFSDIVLDKEDMVLPRDEEGEIDWGDANLDDVEVEKMRRLFEDTLNLVNSDGAPEDQLVDTPSVIDAEFEDDDDDDDEEGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQG2</accession>
    <name>A0AAD2CQG2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="4">3.1.3.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS8236</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.99" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQG2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1943018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="479" mass="53913" checksum="9854FC7E57BC8693" modified="2024-05-29" version="1">MSFSSRRRNYLLTPHRRDGLIEWMKSMLMHSFVLDALETSGGDTFSHFELLIDEHRRLEAEGNGRPSRLKQLVPTVGTFHTRLPLRQAFEVYNEKYKLTKRKHIQISFNEIRHIMNLAQVMAMRKVCELKDVSTDGDAQVKDDAETTDCNDSVEEFNGPKMITFDGDQTLYTDGSNFDSNPRLANYLYELVHSGVTVAVVTAAGYEYKAEKYEFRLSGLLNYFKSKNLTDDECHRFYLFGGECNYLLRLGNDFRLHPVREAGPGGWVTGTKYIPDTPGNWSEEEIKALLDASEIAVAESMNDQNLKGIVIRKKRSIGLAPQPGHVIPREALDETVLRCQSKLSKMNQGSGSNLPFCAFNGGRDVWVDVGNKKVGVQVLGAYLGVDASDILHIGDQFLNTGNDYAARSVCPCIWITSPEETTYILKRILKLAGVVYELDNEKEAANILLGKTASTVDFAELDRRTTAVKEMDVFTGDFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRA4</accession>
    <name>A0AAD2CRA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cysteine synthase</fullName>
            <ecNumber evidence="9">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS3651</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="9"/>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000006">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000130">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="10">
        <location>
            <begin position="32"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1934228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="380" mass="40892" checksum="77D552FDBD3F0C9F" modified="2024-05-29" version="1">MHLALSSFLNRLVSNSGRQIARRSLNVAARPSDLVGKTPLLDLTPYMKKKGVTNNSKLYGKMESLGPCSSVKDRLGRSMIDDAEEKGLITPGKTTLVEPTSGNTGIALAFIARERGYGCILTMPETMSIERRMMLLSLGCEVVLTPKEKAVSGAIAKAQEIKDQMGDDAIILQQFQNPANPKVHRETTGPEIWNDTDGELDLFFSGVGTGGTVTGVSQYIKGCPEFDLPALKPGLQTIAVEPEEQMLLTEAKGGEKRGEQGPHKIQGMGAGIIPGTIDLDYIDEIVAVHSDAAMETCTELWLEGIPVGISSGAIVNAAVEVCKRPENAGKLGVCIIPSFGERYFTHPMFEPMKAKAEGLQKQPLPEPFDNTEFGFATARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRG6</accession>
    <name>A0AAD2CRG6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000691">
        <property type="protein sequence ID" value="CAJ1938226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042039501" description="NAD(P)-binding domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23083" checksum="A53E2DD2E80FE3BB" modified="2024-05-29" version="1">MTATLVCRLHVLVTLLSYVHGLSVVIAGGTGRVGKVILPLLSNHDVSVLTRNSFLASAPNRVTEDFGYLGKTFLEKNPHVKLRDWDGGDLLDIVGQDWVGWSDDVLKKADVIVHMVGGYTEQRTKAAERLVQESYRLKSEALHITVNPVEADIPLLTPGMVTLKTKRIQDCENIVKDNCANTACLRLEAYKTDELCDEIRKTIDDWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRK0</accession>
    <name>A0AAD2CRK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS3801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRK0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1934461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50470" checksum="01094911B80F0742" modified="2024-05-29" version="1">MVVGPPKIAVIGAGAAGLCVTRIVNRELGLNPAVLEAKAFSGGVWRYEAGATNKKKNPMYRDLKTNRPKELMGYREKPWNSPGDSFVSHQAVQGYLMEYQREFDLEKHIEFSSPVQQLTILDETKGGGHSTLSPKTEPWPRIQIEYGENGQKSEIYDAVFVCKGSFTTPSIPEIEGLDQHFNGKVLHAVSYDNPEAFAGQTVLCIGGAASGTDLAREISQHARQVYLSSPSCKYDDSGNLQSLGNVTWVPRTMQVQHDGTIVFDNECSLKPKVDTIIFCSGYRYNFPFINKFSNLEFHCVPGERRVMPLYKQFWHALYPNLCFIGIPHHIIPFPFFELQAEAAVAQFKSFSLPDQLSRLDEASKDSVSGGVKAGGSITDTHFLGSFQWDYCRMMAKMGGVYNDDVEAFIATNKAIYDDSERHRNGIFPGGPDHYRENKYDRQGHDWTVSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS51</accession>
    <name>A0AAD2CS51_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001079">
        <property type="protein sequence ID" value="CAJ1941776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS51"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="284" mass="32852" checksum="521F734A376F05E0" modified="2024-05-29" version="1">MYMTFGKIAFDDKLLGRALNKFRSKALPPLKRQVWEALPNYMDMDKESFENWKNKVRDWILTKCTEEDAAAVLNQLRTWRKPRSATIMENQMYMKKVNSAIPYMSEALDPLDEEEFKRVFFNAHPKPWKDAFLEINSTIDSHSVASITSYMQRKAQQAHDKELKNQLHQKIKSKKKKRTAGVHHRDDSKPFKKSHADPEENKMDKDEYHKCVAELAKTAKPTNICSLKPNHKNHTISECKAINNYKAQMSNKKSNSFAVINLPGDKPDDDSTTSKETDSSNKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSE1</accession>
    <name>A0AAD2CSE1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001302">
        <property type="protein sequence ID" value="CAJ1945018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="111" mass="12432" checksum="EDA4F9CE706D935A" modified="2024-05-29" version="1">MPNEVTYFVQITDPDSAYNVGTLSLKESFNFRNLFKGTLRTNNLDIEIAKIGPSLSNLAEWSGYQVVRDGEISQFIKLMSSSSLMFRSVSITGRADKVTDNVYNDVSRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTC0</accession>
    <name>A0AAD2CTC0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="102" mass="11814" checksum="8EF78D6A0A946546" modified="2024-05-29" version="1">MNRSSRTPATEALNRLLKHQDSESLFREESQRVRKKARSLGKRSSSQHMFDLTSILEASEQIKGLHSFPIIEWPTMENNKDIADVRASQMPLIKSTIVRRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUT5</accession>
    <name>A0AAD2CUT5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUT5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="262" mass="28207" checksum="9F3E488F99FB4CA0" modified="2024-05-29" version="1">MQGGNDKEMLEAGIRPEGAIAADGCMVKQPSTDKTDRKSGLFRKMLLGMKTKSSYGVAFGLISSLMVGFLGGWFAGGAATAAGEISNGAASMNDVTTSGSNSTTTTVYNCNCTTPTVVNSSSTQPEPPSPNANSRVLFPWMGRENTTCYIGEWYQCGDTNGGLDVKYFDRLRKNCPSRNNCDDLAGCAVSKSEIFFEGPSDGTVPDVARLAKGKSSSKDHPMAQFLTFMIIAAMILRIGTTLMEPRWQRVLTQNCSRLQRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUY2</accession>
    <name>A0AAD2CUY2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001418">
        <property type="protein sequence ID" value="CAJ1945428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUY2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="151" mass="17525" checksum="7C647006F803428C" modified="2024-05-29" version="1">MEEKKKEFMEDLKKNLKKKSDGVSISEEELDRIRYKYNMPISAIEDGGYLQYAQYEDHPQEDPRHKIEDDFEEPPDQESDPVEFDKHVSAKVSFNADGVETFGVVQGPKRDSSGKLIGHYHKNPHLDTSIYQVEFEDGKVESFMQIRLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV31</accession>
    <name>A0AAD2CV31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS9647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF21">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1945503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="670" mass="73519" checksum="15BDB5B1222074A1" modified="2024-05-29" version="1">MSLLLSFVRPVQGYNFPTVLGRKLLLRRQIASSTVPPQQLVQPSGWTTRKRQQYYRFVQRHPFSSATNSPEIATVPDEFEQCWRTTSQMVNPNRDPNMDAILQGLNSPAPQSFYILQRAMKEISLTADSASFVENAVQECSYLVKPGWQLVVQKPGLLHHASTAAAAPLQWNLIPLEESTSSKDDSSSDDSIIVTEGSGGPNACQLSTQALNMVSKAADSQQPLDTNALDDLVAAMERRIRFSLGTDIRGRTSADMAFNLCLAGIDNDFLYASLVKVAKLEMERIGQRPSRKSRDVLHVVEKLAASGIKGPEVEEVYQLAAKSLQAKEEYPEVVEQLLSSPFGSLDLLSPRPLLWLWRYSSRLQKPASKESSPARNHMLSWNNKFEDTSKPLVVDIGCGLGVSLLGLASLQQAPSSTASPSSSSSSSSSSSSSSSSAQQMIPLDWSNCNYLGGDLSEATVRFANTIAHRWDLSTKLRYAQLSAEELLDDVMTHYPGPVSLIMIQFPSPWRLPKKGSGGGGGGNSQLALGPDDDKFMVSKALMAKIAKVMQSKKNNNKKNGDDGCYFLLQTNCEDVALVLRDRAKEFGLTLVPSLDPVLLVASKDDDEQEGHLRIPERTVEWLKLNDGDTERAVGPEWSRTPCLPPKCATETEVACTIQGTPVHRCLFKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVC6</accession>
    <name>A0AAD2CVC6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001613">
        <property type="protein sequence ID" value="CAJ1946147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="391" mass="44650" checksum="83168072134D4760" modified="2024-05-29" version="1">MVLLETHQAISENNPSSRSEMASLNKTYQINRTEEKWSMSRLCIKPSLKRIDPEEKKWCPSRLIKPSLRRLHPAEEKWRRSRPIKLSLLYHYRLIKPSLRTIHSARTRAQTREGTRVPVETVHSDASSAGMSRKGDSVTSTISRHSHSTRTASAVSLARLARYRKFEIDSDENKDAPDSDHDATLSDGAPSRNPRGPQPDTEPEDTEPEDQAELTDNEEEEREVPLSAWVHLLTNHCQVNSKQDNIICGKLKSKCRLRLHKELQSSGERAAPRWYEGVPSTKDIYKETGEFIIHGQQYDEEEEHDDTDVNTSKVDSEGQFLDGSDDDHQDDLDQINELIAEIEEAKLKKLKAEKARLEAKKAASQSPRKKKRNLPEESSHCKKEDTEGNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CW98</accession>
    <name>A0AAD2CW98_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CW98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="405" mass="46386" checksum="0BE2BC2A1F476578" modified="2024-05-29" version="1">MKLSSSSSLPPLFRNHQRCLLLQIRGGDPSIEVANNATKVEEEKKPELSLEPPGSTVVDEPTPVENTTKANQTLLNVQKEMEEIEESDVDGEMEEEIEVDSDEEGEDYYTDVEDSELDYDEADEYLDDAEENQSIEKVIETAVYVSERAGVLALKVTKLASFWVRQWSWDIYRACERAVDACREELAAGAEDEDDGTIPFFHTKADKDETRLQRVRKKTWRVTKRTWKTLTKMTIAFWAMDDNDILEFPEEDSDLEVETSIKPIFSFLDKLKLRSDYDDEVDDSDDEDDVVDDVIEPQEEAESSSVIPKKPRHSRRKKRKSKRKTTTKTTSIKIIKPEEDEVKAAVIIVPRIRKGRRVMVGVAVGVVCGFCWQQFGASALIMKGVSMLTRKWKPWRTDKANSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZ59</accession>
    <name>A0AAD2CZ59_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZ59"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="754" mass="85036" checksum="592FC2C3F35308F6" modified="2024-05-29" version="1">MKHPDAKQRHSFFQPLQMRPTNQMNDGRETSGNRNNNDGDDRIAKLKQKPVPKRRLRHANSSESDSESDSDDEVPLSLLASIKPTKSTATTTQKRQRTSKTQRRETNALQTKQSKSNKRTAVHDLRNQGSASKASRQTTDRKSKPKATVQTMLSFAVRPKRESSQSSQSTKNEACVQPREQRAAALSSSSELTRDDNRMDLSTTSPGQSPSLTDGTSASSSSNTIDTINGSSQLQDTEETKEEETVETKRKKKTLRRIVSTESEIDFEPPVPQSPPHSSLLSQLYQRETRGNRIPSCLAQPKKWKTPSWVRLGQPPCVGGYQNSSRKIDHLAWDTMGVLLAVASHSTIRIYHWDMVRAAYLQGQKDQQHCRRTKRRNQQDHEVENSEFVIPPVLQFRVANAIASLAWNPFNEDQLIVGYRITGEVHMYNVDRLATWQSKNPRNLASLPHQSTYWQLSHPRTRGSANAILVLDSTTILVGLGAMVHCWKLSKGRKTSLLWRYQPPAGVTCARQLGANLVLLGTNRGHMCLLNWKKWNTERSFSTEKKPLVMQEWIPHSTIRSSLNQDQRGRMGIINIKVETSCPSYEGTNANTTMKGIESQTNFWGCCRISWVTVSGWLMSTTMRSPNEKSPAEICRATALVKYKNSDGTSKESTRQEYSQPHDPVTVCTNSKWMCWSSVPAVTKVLPHHDKRVLDGQLQVLRSEKRLLHYRDGESTHTIKLAGMTTPQSFAIHPDREWIAMGVGARVVLLVGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZG0</accession>
    <name>A0AAD2CZG0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001691">
        <property type="protein sequence ID" value="CAJ1946478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="569" mass="64640" checksum="E18B69D42C4A47AD" modified="2024-05-29" version="1">MDIFIDALVDQEELLWLNWCRQYLQVTTLLELTTADGRRRRLLQPLGPWSDSLDRWTWLFSRTALILFHRTAASLAIYRPINSRSHKTFRRDLHHTWTGTLPGDVQRASVNLHPRTAYVTVTGTAPVDPPDPESLPASILHIWRELAADMDDNWGWVPEYIYIEGDKQVLLEALEKGKLRVISDGSFKQQVGTAAVQLQTRRGGHVIWIKCRTPGKREDQSAYRSELIGLLAGILVASWLRLRLQSLAKPRVCVACDGSAALRQAFSTWPLSPIAPHFDLLSSICEALRVSNISWAEQHVGGHADQTKTWRQMSWWKRRNSEVDDIAQGYADELIATNDTIATNPKFFSEPCAIYIDNEKVSCLALESVDEAVLLPELMEYWAAKGRLAPEHFRSVDWPIVHRAMKSLKPAEQRFITKHTVGMCGVGKFRKRCGLNSKNRCPLCGLEEDHLHVPRCPSDRAKTQWQLLLQELQEWFQSTTTATPIAQFLGALLCTIRTPNNQPQTETPWYRLHGMSSSALTQVCEAQLRLGPQCLLEGLLVHGWADLQQQFYRSRGSRRSGNLWAANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC75</accession>
    <name>A0AAD2FC75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS2039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008893">
        <property type="term" value="F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF22">
        <property type="entry name" value="NUDIX HYDROLASE 26, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041959883" description="Nudix hydrolase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1930691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="347" mass="39666" checksum="CC686DF065B69BAF" modified="2024-05-29" version="1">MPPLTINLGLRTLLLSTSTAFTPKPCSRNFHQASVMMKKYAPSKFLIDDEQKKWRIAVACAVLNSKNELLIGERINIPNAWQAPQGGVDDAWEGNNNQAETVAEAASRELFEEMGLRTGKDVTVISENTSTLSVEPIRYEAKGNDNWLTKNGFSGQELHWVIFRCTNARGDSDPEFMCRLEGQNGEAQEFLKVQWKPIDWVVENIWPAKRGAYEALQGSLNDAVKEWDEQCNMAIDFDGTWSRDASKNEGVVEALIQRGVAADKAASEAERPYVQKWERKEDDVWNVKTYGADNNLRRDVDYQVGKSWREEDSCNIWRCKRWSQSNNKSHCRTRSRFACCINHDNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCC4</accession>
    <name>A0AAD2FCC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein xylosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1931022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042102031" description="Protein xylosyltransferase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1931022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="49818" checksum="B1867289DC034211" modified="2024-05-29" version="1">MARTRLLAYLGLCCVVALYFFGNSQKLGGYFETKETQNDISTSASTPGSEKKDDSSQSKGNTRMLNSSSESTNAPSSSPTSSPSMTTPTSSISASPSSSSISASPSSSPHVEQSSNEDFSTSLNSSEYATINASSTSPQHATRIEKANTTTSVSVFYHLYLKDDSEIERVTDIVLDQFQWLKQSIHNTVYVNSVGTPMPLLANLSNVSDVLVQSHQTSGSEFITLNNIWQFCNARPSEKVAYLHSKGSFHATKVNEELRKVLSFAALSKECADLPMTCNVCSLKMSPFPHAHTSGNMWLARFSYINKLLGPDSFLQKMGKRDNQFIGKGRYAAEHWVHSHPQVRPCDLYSKSSFNYGYFRVPSMEELTSNLKLEMAPRFSLGHTLERIVENRFARGQIKHYPSFAQRLNEYTMLYGIEKPDLEWWGWTFFNATSKDNRTIPPHLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDB7</accession>
    <name>A0AAD2FDB7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000247">
        <property type="protein sequence ID" value="CAJ1933167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="200" mass="22412" checksum="8DD7F3E3FD1E17E2" modified="2024-05-29" version="1">MNTFFATKQQRGNLMKDDRHVTVEQNQDDMEELMKLFSDLSLNCNETKAKMEEENDETMGLSSQTTTTTATTKNEPNQIVLDLSDPAPLAFSQPATQDVMPQSDCLNAAGDEIEAEMMATYLSLHPSLELATGNASVTELAKRFSGLSIDCNAMEVDQDEMDIDLPEIDWMQVDIDEMEIDVPEIDWMQVDTDEMELDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FED0</accession>
    <name>A0AAD2FED0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FED0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="435" mass="48032" checksum="A1DBFB9414B8587E" modified="2024-05-29" version="1">MNISEHAKKHGTVYQIQCETQNKGKRVASSKRRIRWRFGFANLQAGKTGKDCRGAEHEVVFVWSLNSGKQLILADGHEVHWAKIGRKEKLEVDWNMSNGNHKLKVVAEPSVKSRKSTDSRQFDLLIDGISFSDLPSIYQLGTDAAGSSRTSTAVRSSGKPVLRQESRSYSMPDLLSLPQQHTPPPQKTMQQQSPTSSIDMTVFDNGVGGVEVQFQQPPLPPQQHQCQRSQSATTLPQTQPLPQQQNQQHQYQRSHSVSSPQRSQATAAAAASYNYSWNDATAMVPTPQQAYHSRNSWQPPTAHQQQQQPQIYNWNDAASPQKRGSIGSYASSSNASSNPFLTPQKSLSGYSTPTSSVNPGYDSDLNDSPLSQALKSLGLDTSAHNTSCSVQDDHSVTSHLSVTSNPFDFVQPSVQTYLPTLMIPQVQQPQPNAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEN6</accession>
    <name>A0AAD2FEN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BspA family leucine-rich repeat surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000247">
        <property type="protein sequence ID" value="CAJ1933199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1933199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="93901" checksum="106945EDCDFD43CD" modified="2024-05-29" version="1">MDRMSEPITGPMPGAHADSRGTQDAKDKNSGKERYRRPLGTQSVFTVEERANFEVDKEDNMDGLVMANAVDSHDADLATALLNSMLDQTQEASGGATLRSMDKKSIDGTPSGDNSNRKTSKKNEESNGRDWERFKQNKSVRLCCYLLCLVVLAIGAVAVWLATRNDGASNEPSSQAVGIPNKEIETNVPVNTVTPTQDYDAIENPFISASPSGPPTSANIEVAFDPPSAEDCAAIASGNTIQDQDTMPVQSYQLDLDATSFLPVDLSISAGIIEDKLRELMAPALTGCNRIVRNLRYHRYLDSGAFAYVIGNVAVDASGVEGVQCLDDSSQRFINTFFGDGVLAEKLDLSRLYQSIIVVNLGSMDPTESPSTSNASPSAEPTITVRPTPASEARRPSPNPTAKPTAELTILTTFSPVAGETPRPTPNPTPGLTANPTSSPTPNPAPEQTANPTPKPTSGPTFFPTPGPTPGLTFPPTPPLTPPQPTVALADPTPPPTPSPTPFPALQSTPGSTPKTPTPGPTQNPTPGPTRNPTPGPTPNPTPRPTPGPTFFPTPGPTAPPTPGPTLPPTSPPTLRPTTAQPTPMPTPAPPTETCFQSNSELVGAVDEWFQSSKTKASVERQYGTIGDWCFGPGVTSMQELFRDRTNFNEDIGNWDVSSVDVMFATFEQASSFNQDLSSWDVSSVTNMGSMFRGAATFNQDFSLWDVSSVKDMYSMFYLASSFDQELSSWVVSTVTRMGFMFSDARAFNRDVSSWDVSSVKTMSAMFSCASSFNQDISSWDVLSVTDMSWMFSQATSFNQGLSSWDVSRVTAMEYMFRRASAFNGDLSSWDVSSVTSMSYMFSRATSFNRDLSSWDVSSLTDMGAMFQFTTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG12</accession>
    <name>A0AAD2FG12_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000484">
        <property type="protein sequence ID" value="CAJ1935570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG12"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="425" mass="48602" checksum="CEC1C703DFAB97B0" modified="2024-05-29" version="1">MIKAQRCFQYFFRQPQWAASRVKIWREIKNWYFGYQGANGPNFFSCGFGHDPVCGRLAMQLMDPEWALGDIKGRPSSWWLRKMKEIFSQGLCRPEKGDFGEIMVALYFLVCADVLRRQDNHNHTTFSVSLEDWIEQLTTGGLERRQGHRSDEDVLPKRKSKRLLAAKSQVSRQKLTAEKVDETMDEAYEVEVEASISFIQVCRNYLRACEADWEGFCSQEFLSYMYASGTAFYVFPGCPIIDLVITIKLSGQRKHYFAPMVISIKLRAYYSPADARWECQRMTERFKRIEESNDKEVFEFFPVALCLLVVFGSTAVSDDNDLTLGHSAIRELAKKKVVSRVLCIPAKDAFGGFCNTFRTLTSEITFGPSVVFASHSFVRAYCMDDNAEELDTTSALRSLSGKEESELLQNLHEQFKNGYGSSGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIN0</accession>
    <name>A0AAD2FIN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001068">
        <property type="protein sequence ID" value="CAJ1941724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="281"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="315"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1941724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="56721" checksum="A804F48BB80AC42D" modified="2024-05-29" version="1">MTENQRLQTFAALCAGQSDAPTDKARDASSAGAQNGDSKNSIASALSSSASSSTTQQSQHAQVAGRTSHPAVQNGQQLQNMRAQELQQALARAASHGGTVSPSLAAAQSLFMQGGLSTQHINDAAVTQMALQQYLQQAQQALSNQQASQTLSTNESGSLRESHALMMAALTGGKTNPFGHVRGTDLLQQKVIPSASPSNLEAPTEVANAIAGAGNVGSSSVPTSMKPPPPPSQKSVEATLSTAGIPSILGQTPPKIAPMPGAKPIAINEGGSESSVPSGFDDKKQQKRAANRRSAQLSRKRKKQYIEELKEENDELRRKEQILRSIPDLIVVFDSSGKLGFVSPSVSRFIGISPDELVGTSFWDRLCESSVRLLKSAFMDALAAKKSDSDTCPLGSGVWDLRLVDKESNYTLVSLNGVVHFSGEAPECVCCIRPLEQQQPVQKMTNEVKKQPTARPVSSCDGSSSSNSSRRDALEIRANPNQSVISSDATSADDSGMNSVRRKKPRRREVGRGAEGESVRISDGDSVSGSDDGIVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIP6</accession>
    <name>A0AAD2FIP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000354">
        <property type="protein sequence ID" value="CAJ1934651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="19747" checksum="9C7D5D714B69F010" modified="2024-05-29" version="1">MTAAQTSTAGTSGGNDQPKRGAANNAGRNDNKKRKEIFKGDIEEMGGAVLQFPDERNRRSAAQYERFYMALKDYIGREVSVGAAKLWAKTYVKEMDPSWEPPVPIKPTTNKNDVKALQLYESEKAAYVKHIGATWPAAKLEIWSTIMAQCSPKLRAHLQQLPFYDKAESTHDCIALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIR6</accession>
    <name>A0AAD2FIR6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000369">
        <property type="protein sequence ID" value="CAJ1934711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041986402" evidence="2">
        <location>
            <begin position="26"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="285" mass="30403" checksum="62279172271CCF51" modified="2024-05-29" version="1">MDRPSFFLCFFAITGVFLCGHQAKAFDEAICSAAQVTATTASTCAEWQAVNTELTSGDCCGPSLEVNGTSCNSLCTDAVMGINGNCDIGQQFGSFLPKYEGCLILSVEEAMKKALACEEWGSIIQGDARAFCIPKLGLFSETDENCTDTCIDIIAKVPDYCVAEAIDFFQETPIRDFHVNCTEKVVERVSNKADTCIQWKGLLELSIKSGVGCGDLECTADCETLITSVESNCPGYVARNEWQTIACAGGSSTPTSAAYMVQPTTSILILLGSLLVFGVGMAIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ94</accession>
    <name>A0AAD2FJ94_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001247">
        <property type="protein sequence ID" value="CAJ1944785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="712" mass="80324" checksum="4D061147D7AC695A" modified="2024-05-29" version="1">MGRSADADTLTSVTSEETNSDKLALASATKYRKATQEVKDYEISIDGVDVDEWAKSVPDDGSAGERSPFDRVDILTKRNTTVTTLKDSPALDDAIGFFETHHCIMPTNGPYKLHPGQASDLDWLECNMAGLFDLDPAHVPQLRPPDFEAYKSGRQPSVLFVPETPINFVTESTPLRDKPIDLTYKLSPSGPRHSTHCRTHSEDGRWNSKDNSAEPGPPSHDPNAHDPVLTMEPMYKNLSSAMKLHERSWERLRKWLPKLDIQKLFLWTIVYLARSPVEAHHEHKYHLLASSLESICYMLGTVGNVEHPGCHMTYQFLFLERNNFLFPSEICSAQSPTKLHKRLDLPDGEELTLPTIITSIDLSDGEELAPPTKIKSSDNQTIKTVVYSSEDESGIEDVLLGNWDLIGQTFLLSPDESYVRRAKIVELNYKHNRNKDIEPAHIQLCLNIDKGEYERVMAYRNIHKWSEIDTDTPIVWNLKWVVCCHHYIRLEHPSYLGLTFCMAIGWKHGENTPEALSITGADDSVTYTIHARNHNLLESQGFKPLGNIVKDKKKLLCPSNQVKLRLLHTTSPKCMLNGTSIDFLSKEQPTVETATYDSEPVATQTCAKQIMDLQQTLRYLGVSIRGQSYMSGDNESVMNSSSLPEAKLHNQDVALSFHRVREAVAANMLSIIHIDSALNPADILSKHWGDQQIWTLLLTLMFWSGDTAERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKF0</accession>
    <name>A0AAD2FKF0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKF0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="329" mass="36656" checksum="9CE90189A31DDE5E" modified="2024-05-29" version="1">MDEIKTSTRSNIGIIHHCSSRQSRADQPRKTSFAECEIGSSRKRKLSASCCYEQPCHLKAAQSPEPLAMSPAVYLSAALRNKGIPSRVSHLSLEQAIYFEPYREAQIPATILRALRSNDFTGLEGVEMEQLRRQRNSFGETLTHLVCRSGLTSAQFLIEKVEIPLNVRDKFGRSPLHNACLAAIPNFNTVQLILKHAPKLVLFEDNKGRIPFDYISARNRSKWSRFLSEDGVLSQLQTALKKEQKKEGSETIDKILRLSSAAGSTINKKDYKGLAPNQPKESSQNPSVIDGNGRPNECIMKLFSRKPISFASPLPTPEARASAPLRVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKZ8</accession>
    <name>A0AAD2FKZ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="7">
        <location>
            <begin position="738"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1394"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="339"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="425"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1938952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1418" mass="157092" checksum="E5A785D89B24AE51" modified="2024-05-29" version="1">METPAHDPASTNGATNKDDSANGENGNNVVFASLSTGKPPLGRHASSGDQPITLGTRQDSVGVLPDASGPNPAAAENPVRAPAPAVALGGGVPTPAALATVSTVKPPSPKTLAANGPPPDVSRNAPPPVVETTKVPDPPLQPTPKPELAPMNEAPAPAPSVAAPAPAPPESPSSPSPASGEDDQDGDVSMDDADEATSEESEEANAPVAAAPQEKPKAATAPAAAAQPKPAAWPPQPAPGYEARGGTEMKELKVEDALLYLDDVKKEFGHRPRVYNEFLAIMKNFKSQEVDTPGVIEKVSKLFRGYNNLILGFNKFLPNGYKITTEDLKNQDAKYAREQQQQQQQEALRQHQLQQLQQHQKQQQQQQQQPVPMEMQSQQQSLSARSPQAGIPAAAAANARPAYQGHDPRVLPSARIIPNPPQRPPAQARPAAQPQHQRPAQQQQQQQQQQPPQQPKAQPQPQQQQQQQGGQGHQAVEFDHAISYVTTIKRRFANDPSTYHSFLEILHTYQKEQRGIKEVLEQVARLFQDHPDLLREFTFFLPDAVQEQAKERLQRAAADSEARQAAAQRAAMQNSSMDVDSSSKSGGGDGGGASTKFIDMTGQNGGNSDARSRKRSQSEMATDAPVTVAAPQAPETYVYNSAVERQFFDAAREALASYTRDGGQAWAEFLKCLDMYAQEILSRNEMLNFVEPLLGKRNTKLFEEFKRILNAAGSASGQFPSFEDSWHSVPLSEIDFSRCRHCTPSYRALPRDYPAPPCSGRSDEESKNLNNVWVSLPVGSEESYTFRHMRRNACEEVLFRCEDERFEIDMVIDSNACTLARLEPIAEEIAQLAENELIISESSTIPRPAAGEQGMGGKRYQFTFDQSILGVIHRNSISRIYGDAGQEILELIEKNPTVTIPVVVQRLRQKDIEWRRVRDRMNRQWKELAEENYFKSLDHRSLTWRTTDKRVISTRTLVAEIKDRSLHKGKEGESSLQARMDKAKEEHGTFYQVTMKHSLARDLDLTSLPKADRRLFTPHMSLMGTNDSSVHMDAYRIISFAVERGAINPTDKERIHRLWIEFLGPWFKLSTNQMLMPAAAYQESSKKDFAKKMTKIVSEDGDTGDEESLDGETNVRVVTEDAVMEDQKNASVFLDHHPLPSGALVSTLFGEGQVIKFRRSDNTYIVRLPFGKAYLAPSGILCSILGPEKSAYTTQLREKDTSKLLRPDDQFAIGTQSLYLFFRLFQILVERLEIARELAYNAKRDQTLQSMVEKMEGHDEAALGKKRYDAFLSLVFGLLDGNFGGTPATSGKYEDRIRMLLGHGGYAMATMDKLISHILKNMQSMVNDDAMWNLVQLYRRHLEGGDFKPEAFRQEAAFLSDGEVMFAFQKCPIPKNGGKKCVLYIEHLGVISESDEEGGSVVENTEASPANKRPRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMA1</accession>
    <name>A0AAD2FMA1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMA1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042183350" evidence="2">
        <location>
            <begin position="29"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="453" mass="51259" checksum="34C1770A86AB1B49" modified="2024-05-29" version="1">MVRLISRTISGAQFLVMLLSVMATFVHSDEEQGNMEESIAVAEKHPSGVKPYFVFSTISIACMGEIEMLCAGAEDVEDLPCPSEIESMPFESCKTNSCLYLHSMLEVLDKKDPAGVVHRVELVQKMSKNSNVKISQECQTSVFEYIRAQEFLRILESGPQNWMERVQLLEVRANMISLWFMGAIFNPMSLLFHCWVVLFVAYKGFKSYRFLKQVKEERQCVLECVLANEGMKTRLEELTNQKLDISPYSLTWDLQSQTQQFAKVSNQVKVLRAIYSDPDLKLQFRLLDRFVQSDLIMSLTPPVNSRTLERGFNPPRPWFSPRPATKFSLFYAGYVFFVMDLNLPPWMKLLVEVCAVKLVISSARKAYGTPGGYRKSTCCHCGKTSLQADDKKNEDVDCLVCSGTGVCHLACTVCEQRLQTLFPSNNVFLPGDAPPGYAPVPAPLHTRTHGRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMT1</accession>
    <name>A0AAD2FMT1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aminopeptidase N</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS10670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001711">
        <property type="protein sequence ID" value="CAJ1946529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMT1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09600">
        <property type="entry name" value="M1_APN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000002">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000002">
        <property type="entry name" value="Putative aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.10">
        <property type="entry name" value="Peptidase M1, alanyl aminopeptidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038438">
        <property type="entry name" value="PepN_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012779">
        <property type="entry name" value="Peptidase_M1_pepN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024601">
        <property type="entry name" value="Peptidase_M1_pepN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037144">
        <property type="entry name" value="Peptidase_M1_pepN_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035414">
        <property type="entry name" value="Peptidase_M1_pepN_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02414">
        <property type="entry name" value="pepN_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46322">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46322:SF1">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11940">
        <property type="entry name" value="DUF3458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17432">
        <property type="entry name" value="DUF3458_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="12">
        <location>
            <begin position="123"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="9">
        <location>
            <begin position="242"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 alanyl aminopeptidase Ig-like fold" evidence="10">
        <location>
            <begin position="461"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 alanyl aminopeptidase C-terminal" evidence="11">
        <location>
            <begin position="555"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1946529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="99017" checksum="2950CFB4DDA82DEC" modified="2024-05-29" version="1">MNTNISVEESTAPVEIFRTDYEPLPHAVTKINMDFNLNDRKTIVTSELTIQPNKLYKGNSKDLPLDGEEKIVKLLSLSMNGKDLKEGDDFTLAPGKLVIKNPPAGAVLKTVVELVPEDNFKLSGLYKTGPMYCTQCEAMGFRRITYYPDRPDNMAIFEKVRLEADKKAYPVLLANGNMIDNGDLDGGRHYATWTDPFPKPSYLFCCVAGDLGKIHDTYTTMSGRKVDLQVFSESHNVHKLDYAMESLKNSMKWDEDRFGLEYDLDLYNIVAVDSFNMGAMENKGLNVFNTAYVLADKDTATDSDFERVEGVIGHEYFHNWTGNRVTCRDWFQLTLKEGLTVFRDQEFSGDMNSKAVKRIEDVRALRGGQFAEDAGPMSHPIRPNSYISMDNFYTATVYNKGAEVIRMYQTLLSVEGFRKGMDLYFERHDGSAVTCDDFLAAMADANGADLSQFSLWYFTNGTPVVTYDAKYENGTFTLLLTQKSKSDKPLHIPISVGLLDKASGEEVVPTKVLNLKEMTQEFKFDGLKGEVVPSILREFSAPIKLISASGKEDEEALAYLAARDTDGFNKWEASQKLFTSLIFQAKDGGMTEKTYGYVKEAFGRTLTNKESKDYSIIAYALIMPTQNTLAELVDVVDPVAIHKARGAVKKRLARDFATELKERYDELTAAMEGAEFKVDSESIGRRRLRNVCLGYLCEIYETPEEQKVASEIAMAHFKNASGMTDKAAALGALASMDGEGATARDEALEIFYNDAAGDFLVLNKWFTIQAMADLPDALDRVKKLKEHPDFTLKNPNRCRSLVRAFTANVAFHDESGAGYAFLREVLEELDTLNPQISSRMAGALISWKKYNEKRGLVMKAELQKLADMKPISADLFEIVSRGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNL0</accession>
    <name>A0AAD2FNL0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11094</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15978</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1955908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNL0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="448" mass="52292" checksum="F0DDFE630A425D5D" modified="2024-05-29" version="1">MASTHMLRQTIIVNEGDSPLAYKAREVTNPVMQYVSFFDNNFERKRKVEVWNGASGKNVEPLLRSIQSFRNISSEWGLNQGRQKKALFKQFLTAEPHMTYQRISEAHGNSVQDFEDSVDEFICEYTGENPKYQANMYLFDTSNHIRKPYNTEIGIHANRLKTLFMYHDMLPGNCSNVNDENDPGQIRKRKLALFRSFPIDWQGDFINSRNDPANDDNITWKDIVSWMTQKKRTVDRKRLMQESSPRRTRPGNRTGGRGLHHNRFRGGRGHGRPSNGYQPYPRPSSSPRYSQGTSQSFQRGGNSHQQNQGRFQPRHPNNGGRGRGFNGQRSGRSQSGRFQPGRNYQGRGQSNQQNSQNFYAESHYNQEAESFAAECSVPEWNQDGMSYGGMPSAEQYQHQEQYYQAEENQQWNDQYNYEQEEYYPEEQEAHEHFSYDEDSPFSFHEEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPA1</accession>
    <name>A0AAD2FPA1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001731">
        <property type="protein sequence ID" value="CAJ1947540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPA1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="33123" checksum="7F6FE3A73C0A3EA8" modified="2024-05-29" version="1">MDLLSYQIPKDYPTIFMNNNSDGTDPTAQNLPDSAPTDARVNGNCLRFRPITFPILKSASDSTFDMVRLRYWTKKQGIAYLETFGLSQVYIADLCNAADNPDEQQPPHPTTWNVPGVDIRHHIDALMHLCFLGITKAISTDLISGWLKAQRKSSSFYNLSHPVLDQIKRQSLSWCKVETKFGGYVSENWIAYCLVYKYVHQLLSKLTEDDDVYIDPPGVPLSQYNLKQRRAWLCARKVEDISNKSLKKAVDKKFLEFISLPPEECPPIIQPVASKATLEQASHMIICWQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPV0</accession>
    <name>A0AAD2FPV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Inward rectifier potassium channel C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS11811</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1948873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="13">
        <location>
            <begin position="129"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="14">
        <location>
            <begin position="217"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1948873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43938" checksum="32DCBC8544BFEC7A" modified="2024-05-29" version="1">MPPATTAINAGGGGDNNNHHHHGWKLRNYRLTTSILHGAVDLDTSCNFIEKPPEEESTVDIEGGRTVTFAMMSNVTQRPKISHTKIKRAKCVNLNVEPEKSSVLGRFGHRLQRYLTKKNVPSLTVLYLVAFFIMNAVFALLWSAETDGCCDDPTMTFWDHLDFAVQTSSTIGYGGYRPKGRLNNALVVLQTVLAICLATVYAGLLFFKFITPSANFQFSEVITLSNVMGHPCLEIRVGNADGNANKLINADASLCVTSIQHYRCPHEFNLRTTEETEELELFVNSRHRLDDVWTLRHFIDDKSPLYGFRFDEFPGNTIRSLSLNVKAIQRATKNEVFGQAVYHLEDIMVGHRFEDQVTWDAGTRTAFIDYSKMSSTTLSMVWHPKSTGTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPY7</accession>
    <name>A0AAD2FPY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001744">
        <property type="protein sequence ID" value="CAJ1948165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="103"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="240" mass="27432" checksum="95C58AFA5EF4F0A2" modified="2024-05-29" version="1">MKKSFPVEFADYAKLKAIDDEPTFAWWVPHVQRKRDSFIQKIKSKYWERTHKYGIRIPTSVKEAIKIDQENGDTMWQDAIKMEMKNNRIAFEGYNGDVSKLVGYKQITGHMVFDVKLGKNFRRKARYCADGHKTEAPAALTYSTVVARDSVRILLTIAALNDLDVQCADIQNAFLMAPNLEKCYMIAGPEFGDEEGKTFLIKQAHICGLKSSALAFCLNFVKTLEELGFYSSYADPDVWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ52</accession>
    <name>A0AAD2FQ52_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ52"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="651"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="747" mass="85791" checksum="7450522BBA44B9E5" modified="2024-05-29" version="1">MGKKKGKKADDEKKAALQARKEAKAEKAARKKLVKQSGNDVLAATEDEELDKVLQAYKSQDKVENVEKATLQDIETEFPLARANATFVSCVDEKKDYFYLFGGEYYDGIENVLLDDLLRLDVAKQEWKRVLTSPRPPARCAHSCISYKQSLYVFGGELATASEYHHYRDLWKFDLKTLKWTEIMARNPPSARSGHACFLWKSYMVLFGGFFEAARETKFYSDLHVFNLQTEQWMALPASRLSMKPEPRSACNVGIFGDKALVHGGFTKLKTATSTTETKVHTDAWVLNLSPLQQQKAPTWERWISSAKGNAELRPPNGRAGTSSVTYKNRLLVFGGVRDFEQLHHKVDSIFYNDLVALDVERRKWFPLRVKEKAQGGKRRRRKPKEDGTEEEESVNEEGEESSSDIEEEDEEEGDPNDQTGWDIDMLRANMFAFVDGDGNIVYEKIEDPDAKVEPIEEKEEEKEEEEEEKEEEDDDEEEKEEEKEEEKEKEEGKEEKPRSGSLIHKKIASSSVMVLNPETQAPEAVERTEPLPRINPSLLVHGNMMYLMGGILEVGDREITLDDFWALDLRKREKWECLWKGTMHNQVWRGAIHDDDDSYISTGRDDDSDDDFGSSDDEDDMMQSPDDKKSKKNKRAGLKEEIAELNVKHNLDDENRTPNPDEALADFYSRTSEYWNGQAAEAVLNTGEELSNKELKREGFNLAKVRFDELKPVLDRLMELSLERKAGKEERKSKDDKKKDKKSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQM2</accession>
    <name>A0AAD2FQM2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1948877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQM2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21025" checksum="10155AEDC0F1421C" modified="2024-05-29" version="1">MSGNNKSPPLIHRKLAVLGFRAVGKSSLTNSFVNGSFSEAYDPTIEATMSKLVRFRKVHFQCDIVDTAGMDEYSSLSRNASLGVHGYVLVFSITSRQSLDTVSQVNDVLLNTLGDAPEDQVPRVLVGSMKDLDGMRQVSHEEASAFARSIGAPYVECSSKTGDNVADVFHTLLKEIEKDDGLLNETGPSPCLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQP7</accession>
    <name>A0AAD2FQP7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQP7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046423">
        <property type="term" value="F:allene-oxide cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009695">
        <property type="term" value="P:jasmonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034871">
        <property type="entry name" value="Allene_oxi_cyc_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141493">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042114243" description="Dirigent protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37155" checksum="E319592E2F7BE0DB" modified="2024-05-29" version="1">MIVRNILLPAIFIVTYLNLDTVEATKGLSSQRQNELDTITPLNEKENEFLMTLFNRGIFRRSNTDDNDDEPQPVPMRRRLSSKKSKKGSADSDSSRRHTHKLEHTTFGRKSKKCKGKGKGKGGSSSSSSSSSSSSKSSKKCSEYSYSHSQQGYGAVDLLPISLYFAQQRANAVVIPPGNETGEISWGAVYTYDGSAFVAAESAPVVTDPNGGLILDYSNYTIQASDVVGVSTGRCTRIDPNDQSSALFEGKMYCELSYGFEDNGEFTYLTAEGVARQESGRHPFAIALAVTGGTGVFRRVIGELSLAPASAPDMSYYIEVIGNLYMDSRVVDAETYKQIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQW3</accession>
    <name>A0AAD2FQW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS12414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQW3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="259"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1950084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="519" mass="59368" checksum="838988498A82107F" modified="2024-05-29" version="1">MAGTAPNSPTRQPRTVDNPLPHVLPEGQNAAPLEVMGSTASDKVVVIMVGLPATGKTHIAKRICRFLSFFHDIPAQIFNVGDYRRKLCGTQMPAEFYNPDNPEGLKARMMACDAALADLVEYIKQDGVRVAAFDATNTTFQRRQHIIKVLNQQGIRSKKIFIESICDSSTILDDNIRNVKLNTPDYRDVDPEEAVDDFKLRRANYEKVYEPLSERDGSYIKIINSKQYIVNAIRGYLPLKIVHFVMNLHTLGRTFYLTRHGQSEYNLLGKIGGDSGLTPAGTEYARRLAQFAKEQIIHKDGVERPCRLWTSTLRRTKQTAQFIEHNKFEHMWDNGEKFEWIQLRRQERRNLDELYAGTCDGMTYKEIEEVFPEEFARRQDDKLAYRYPRGESYMDVTLRLEPLAQEMERTREPVLVVGHQGILRILYAYFMGLDRKEAPYVSIPLNNVIELTPHAYGCHEKRYCLMMKEEMLNDGQDEPVTSMPEKGQAPPGVTKRDSSVMAENMIFAATDPIMNAPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRZ1</accession>
    <name>A0AAD2FRZ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRZ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="325" mass="35118" checksum="58A0575B62B0AE59" modified="2024-05-29" version="1">MIFPPASSSSSSSSSNDDDNDGEDGKFMTFDVRLKKMVTTYFDNNNAEVIAVEDEQPDGTYSYGNLKYSFLGGICYGMGSTLMAGGNNHATSKPKGTASTLGRILVPGFLAFETHHLMSHFLYKGVFHEERPTRDSSFVRTDNSFGYFENFVNYELQIVAGATAGLSYSLATSLLQYKPKTRAMTSTHMLSFAALFGGYDVYSDVLSSVLLQIKQDQESSAATKTTTTTAPTPMTVALAGGCAGMTQAWIIDFRKIYMRAGGTSSNSSNSTLEFASDAAATRYATTTAAAETSEALLTRARMTRAFLPGAAAFSAYEWFGTLLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS99</accession>
    <name>A0AAD2FS99_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042258076" evidence="2">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="219" mass="22701" checksum="7C6BEE2DE4492809" modified="2024-05-29" version="1">MKVLFNIFAIILLIEAAAAQTCSLCPGGSGSITDPNAKLGTSTCGKVESDLNRIPNAACTAMSLSVNFYFDYSAFCCSDVPTPEKETCDVCKDGYIIMQDEIQTPGNNLVGTCGELKLASFYAEAGPACNILQEAAISCCERAPPTESPTKRPTTPPTASPTKSPAPTEPPVGTTTQEGEGNPAINAAEGSQPDDEASGASSRSMMLLGAVALVMSYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT81</accession>
    <name>A0AAD2FT81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001813">
        <property type="protein sequence ID" value="CAJ1952677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="387" mass="43880" checksum="994A52DDFD35D161" modified="2024-05-29" version="1">MIFFPEGYEPTNKDILCGRGKGNLRHEGNQHFMEIIRANLKRYTNAPKRIDKSLVVSLIVSSLKDDGYKFVRQDTKSRMWFQLSEPQVHEKAGHAIRDILKKGGNAVQQQSQSKQAINTNSNFDSAQTNEPDIVASQILSTALKVSKLVEKSKLDFTALSSGQTMAPDYVASSDPQRRNSREYRRSSIVRLFDELSPEEPADALSSGGFMNDQPLPIDARNSGALRTSDMMQVFESLANSTSDAPHQQQQKQVEEEEESIITPRSKRMGSSSREFRRSELLQFLDFNEDELMEPEEQAQDTPSTDQPLSMDTRTSDTLNSLFKDQEDIFSNLQNVFGSLPDAENADQSPQEMEERNSRASQVLSELLKRQEGIFEEFQNFEAEFDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTN1</accession>
    <name>A0AAD2FTN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS13784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="4">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1952923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="407" mass="45763" checksum="E91714DADC35956A" modified="2024-05-29" version="1">MQTSANGGDSSNEIIYNKVILAPMVRGSELAFRSLVRRYHVTNCYSPMLRSEEVVRAFQVWQNGNFQNYQDPKLLDELKHEDGVLFFTDILRDTEPLTVQLCGCDPNTLSEAIHALLTLINPGILQGVDFNLGCPQKCASDGCFGGFLAEKKPELALECVAAMKQAMDGFRTDRKPVLSCKIRLLEDQGKTLDFAQALQDAGCEILGVHCRKRSDKHNGPAALKIGKLLATSLSIPVIINGMDVAKLQDIKDTLRTTQAHSVMIARNFLANPRLLLETTKEDPAELGAEYLDCCEEYPPPSALYIQKHLRWIFRIHLEPAKAKDGDKIDYSDWRVRLWTFMVRPYITTLYQFRLLIALYVKLNGSTLPAPLQSLPEPSFKSIRHATREPPSRSKDERDKKRAKTADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTX8</accession>
    <name>A0AAD2FTX8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTX8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39948">
        <property type="entry name" value="GEO11419P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39948:SF1">
        <property type="entry name" value="GEO11419P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="74" mass="8081" checksum="5330843EC70278B8" modified="2024-05-29" version="1">MANFVFSLLWAVLLIFIAWPVAGICCALWLLLQPFEACLSFIKGITGFLEKLITWPRDVGHAIASGSSSFPAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU58</accession>
    <name>A0AAD2FU58_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="288" mass="32210" checksum="21DAAB13F2280359" modified="2024-05-29" version="1">MELPSTQGPHEEHAHDSSCTTNSPKSPVDTFSWERSAVKPPTPNIIFSEEDVQGETSMNTYRRKSYNDARGPAKKPQRVFTARVSMAGKQARRYANDDDNIFSIVEEEEKPRMAKLERIPRSHIQLETTTSTTATTTANKPSMRRPRHSLPNLPSNTTSLLQKEVRISQFDVSNTSVFRRSAAGRQSQLSPTRTGREARFGRQRELSPPLTKKNNLVSERRKVFSSPTNKSPTAVIKPPRRLDSWLPPPPLGQKSQPGTPSTVCSGDEWSFASWTDTPAAESKKSLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWG0</accession>
    <name>A0AAD2FWG0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053213">
        <property type="entry name" value="RLP29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48009">
        <property type="entry name" value="LEUCINE-RICH REPEAT (LRR) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48009:SF4">
        <property type="entry name" value="LEUCINE-RICH REPEAT (LRR) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="135" mass="14430" checksum="597409163221E97E" modified="2024-05-29" version="1">MDDKKDNSAASDGDGSSQLNLGNYTWPAGNSVGGMIPTKIHQLNLLSVFDAGENQLTGPLPSGIFVSMTSLRQLRLDKNDLSGTTSPPIVLSELEQLELQNNELIGEIPALPRTLTFCNLSSNMLQVVNASVCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXI8</accession>
    <name>A0AAD2FXI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS15837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13704">
        <property type="entry name" value="Glyco_tranf_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1955613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="48043" checksum="186C3A6580662C41" modified="2024-05-29" version="1">MMIHRRRWKSGSFSTLQSLRAGGGRKTLPTVSSVADDGDCRDDDSDDDDDDDSDSETVLLPGSATITGQQSKRSSVFWLILTVIITGAGVVLTLEIIRTLSQQPERFGDTNNNNNRAAICAIQKGAVRYLDEWVQYHLLAVGFEDIYLYDNSDDFEIQAWYHQSLDDTSTTVSTASSSDRSNKLKQIIHIRHFPGTARQNEAYTHCIKQIQKARSHQWIAFIDIDEFVVLRDTQQYPTISDFLESLPPEYGGLAMNWVSFYWNHQMHYQDLPVTMRFQNRSDHATNRHIKTIARTHLVRKVSNPHFVDYLLLFRWWIHTYDTNGNIVEGPFNYELVDDQIVVYHYQCKSLEEYKERCSRGRATTSKEEWSSQLACQSDEHIMRKIGKFPESIKDDAPWQLLMEKVPGYANKYTNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY64</accession>
    <name>A0AAD2FY64_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001905">
        <property type="protein sequence ID" value="CAJ1956182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="129" mass="14910" checksum="5AA0179275487E90" modified="2024-05-29" version="1">MEDPINLDCTCATQVALPELEVYQSHKQPLTQEARFELVLYQSHKQSSTQEAHIDDDTRKPDGRNGPPSCNSFEHGLQPTEVEPKNPSSAVKTRERDWERLCSYFAWLPKLVIQKNLEHYLEDSTQQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY82</accession>
    <name>A0AAD2FY82_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001909">
        <property type="protein sequence ID" value="CAJ1956244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="29658" checksum="38737444189D83C8" modified="2024-05-29" version="1">MFQRHDESIQDGKSINFNVIAPRLNAPSQTEAVARETEMAQNKILYSAKLDENMRRSAYFETNKRTVKSNIMLKFVTKAMDIKLRGEANFTTTLEDPIELLKRIEQFMKKSADAEYDFLDFWEANQKFFAMKQGTTKNLMHFKEQFLRQAEVLQDLYGVAWFRDFAVKTKAYAAIASTDTAAQNKFKDDIFIAVLAIGFLCNCDWTRTAPLMLDLQTNYCREVEYYPKTVSKAQDMLKIHMQLETTSLPLSKTIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYX4</accession>
    <name>A0AAD2FYX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HECT-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS16499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001931">
        <property type="protein sequence ID" value="CAJ1956999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="170"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1956999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2096" mass="227322" checksum="80684DF5DAB0AEF1" modified="2024-05-29" version="1">MSSNPAAIQGWVKSVDPNSGRFFYANHITRKTQWEPPPNWVEESSPAHTSSHNDNDGTNETLPGNWEVMHDPTTGKPFYVDHERKITQWTRPKEEKKPEKKISFAPASTTESSFSMQKFLQFDSVGNPQQETRSYSQEAAYYHQSHLGGMDVDFSDSLPGLDFSVKKVADKLRLNCPACDGLFTLSVRRHHCRLCGDVFCHNCSNNRVSLPLEGTEFEKPVRICNSCNEDVSRGNFFSMRRYLTPLQLFDPDDPVDEDPSGVTSPPNVNAALSSLTSDLDQMVQSAEGFDEKLTIPASILVPCVTKHLGTKHDTSDRAIRAIASLLSVGSMVGKNDYAYAIYFQDGHRTLNQILTILERSGSSRSTLFVQEKAAQAMFYLTESQILVSMMQTRGEFSQTVESDPLDSLDIQRTIRNMLDHSSVNKNPHLQRWATATIRNLILEDQRRACLAINEVAAKVASGESPGSLAYESILDQLVSTGGVMILCSLIGADDADTRAHATGALGAILTATRAIDGSMSALSEMTGGVAGGTEKKDGNIVRAIVAGGGCGSSVSQLLLSADNTVARMGCEFIGSLVLPLLIDPLGSATLQSLYDCRKDEGGLGACREAALEIASGSCLPAILSLVRENGRASRPIELRKSAMETLAATVLAVGEMGKAWADGKYEEGIGRNGAPAMLIRAIALLNEERVVDIALESLNSSSVQSLGSSRDTPSSRIREAAGTVLASLTSCSAEAIIELHSRQVLSQLLVSSDDTSMTAPSTLRGDAAPRCLGMLEAAASTLIFAWQHPSGAKSELLDRLMEALDAGTITHLFRVLTSKMDWESRDKSAGGMKARSAACRLLCCLFGIASTGDTSIGMKRLLDACDADQMGRRSSKGARNVLEAVLSVLQTALNLAHRVILGSTSRGAHYHAALLDLVDSSLLATGSMCGSSVAPGGGDGVFVKGDDFLVSHNDDFAERRKEVCKVACDVVIRSGRSGPALLPTLLVGGFGEGAVSSSLRLSLAIAQNGSKEQHMKLALSGILVPVSDILRAALSRGDLYRFSAALALVRFCGPHVAAGKGGGVPAIRDAIRVATNVLTLPVSTEANTNQLRTQESLKSECIGVLESLSGNASLWSTICTDALPAIVKYLRSCSEVGLCTPTMSETESSALRTVLEIVQVPSHAVAAAEEGLSTSLGKIMKKYTQPESSEYKKNLEIGLLAMETLHVLVKQPNARQHCDLLCGSALSSICSTIVLAASAEGKSTNETEDIIFFGLEVLSIAVSDIEESMDTAHVLQSSEAAAFLESILAEPRFVRCLCAYILPLQIEAHENEKSFYDVPLLYGLSPPVVNEACGGYQNSRECALFLLFTLSVYACAIESPQSESFWNTCLLRDCPMSRERDNLDVARASATFCSAYLQLLEQDHEAVVPSNRDKQLDYENLTRPLVRYRLLESLGESLSDLTEEAAEDSKTLDDYMLSLLVSYNLPCIFLSVWKDPALLELTYELMKMTVEANQEGVLHLFVKSKESVVSIFDLLNHKPDNVPEVDIRRIRQFLVTTLEKLAETGLLMEAVEKFGLKSSAIKALASACLSEDFVNKEEELTSHLLASGLIQCLVQLCTVKNHDKDGRQQREIVLTGTEAEAIALSLGRKICHMVISRYLERAKLQQYDLDEEEIVLNAPDVSLLCAMAQHSKAMKILESIGGLHALAQVAADGEPNALAALLEGSKGQPLLLLEADTYLSVLSLLSDEREHAWKNDAKMQSVVETGAFRLLSQLSDESLKGRRLIFEASGFEHSIVRAKEVLSSWSLADNSEIVDADDTKPWKYDSGRAENQMNLLIAALSYVATMTQVSEACSLFLDDEDWLLIVSNMASSGISTDLQIEALKAITSLSMCSSADGFLPTERVGEIFQGVLRVEHTSQIDGSSRVNELYSLATEGILCLFDSLPVEQQRSLVTDAALRYRKLLKSHTIDRTTKKGSSLDQGGLIAYNITSIIMIASYNSHLEDVLDSSLIMSLANTLQWRYDPKTAIKRTEQCSWDASVTQVLQILSRITLRVDSIFEKAGFSLQDLTEVVLMVAAPGKAPRQAISFLHALEEAQKVGEPASKLAARRIARTLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZD3</accession>
    <name>A0AAD2FZD3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZD3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1570.10">
        <property type="entry name" value="HemS/ChuS/ChuX like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053733">
        <property type="entry name" value="Heme_Transport_Util_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042285930" evidence="2">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="197" mass="21727" checksum="B24AAD9AC5131F04" modified="2024-05-29" version="1">MNFLLKLFTIFQLVQSCLCFTIGPQPAVSLNRQTTTKNDDRGSSTLKHHPESTGTDTTTPELKLSESEQNVYNFLEELHNSDFDFRIVVVGNGAILETTAPLGPNMKVSESPATPGQHLVTFASEDASFEFHVKIGQVSKVAIVEKKVSDIKTLRILRMINDDTGKSICSLILADQSSEAAGWFQSMMAKHGSEMQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0D8</accession>
    <name>A0AAD2G0D8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS17352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0D8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="606"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="703"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1958790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="782" mass="86195" checksum="7351B26ADB3B912A" modified="2024-05-29" version="1">MSQHQQQQQTIAAILCRSPNNRRKTIRHSQWESKAAGQSTTIFAKSWMIVLALLFLGLPVFLFAEIEVEQKVVHHNKGDHHHQLQHHLRENVHPSQIPKVDAIVVGSGLAGMTATLRILDRGGSVIMIEKESILGGNSNKASSGINACCLERDEKFNDTIAEFLQDTLQSAGPHANIALIETLVDHSAAAVNWLYNRVGVDLSQLVLLGGHSKPRTHRPQFGFVGAEIMSAIEAAIYNYRATGRINVMLNTQVLKLLHDEYDHNQVRGVQIRKLHDKHHLKPLNLYANDVILATGGFASDRSRGSLLEKYRPDLISLGATAGNFSTGDGIVMAEALGAMTLDMEKVQIHPTGFVDPQQPDNPNKVLAAELLRGVGGILLNRDGQRFCNELGRRNYVVDKMMNQKERSGEPQRRLGQRQSGHTFFLVLPSDSANEAKSHISHYLYQHLMTEVSGVQGLSERIGVSRDVIEKTLRQYQTHAVTGKADEHGKTVFSGFPLVNFDTETFLVGEVTPVLHYCMGGIGIDAAGHVLNENGERIWGLHAAGEVTGGVHGNNRLGGNSLLECAVFGSIVGESIPIVERHYDSHNGENQEVAHPLDSAIFQNPLLPVITEAELSRHNTANDSWVAIHGHVYDLTSFLPEHPGGIDSVASLSGMDGTDVFAALHSRRILDRLESQIVGRLDASAEFDLNKNTNNANVNTKHPEENLSLDTVWLHNSETDCWICIHGNVFDVTIFAKTHPGGSHMIHKHCGKDATLEFEVFHKKGIQLLNGIEHLRLGELSMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0F1</accession>
    <name>A0AAD2G0F1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0F1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042273517" evidence="1">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="215" mass="23738" checksum="A079E7893D26595B" modified="2024-05-29" version="1">MGIAAHLLMSMMTKPFCTAAAAAATRERFATAPTSDEASCVQRPPVGLDYYPSIQAHCPHPPVIDQDQWVADTLVSWFLTNTTQTPDGFYWHSNLTIHRRKKKKNALSPFGSSSLGIFATGSIARGERLVAFPPLDTDNIEMSTITLLMDLLCYNCPSHDDHRNPVHIKESSTTTILADHGTEASAAKDLQQGDELSFGESSLLLPWCNHWLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G391</accession>
    <name>A0AAD2G391_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS19099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="192"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="600"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1961241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1374" mass="157525" checksum="89B92A7857C2B1CD" modified="2024-05-29" version="1">MAGMKHKSKAHQEQVKSPIASETNGTSDWYSKTKTVRNPIKAGAYSPPNASSSTIRRSPISVMNHFQTRTRKQRQKLRNMSISPTNRRFILVFGFFVLAGLHTVIVTTQLQKYLKEDAANILQTSKASFKTSEMKSKEKIPTYRGLEEEAVEGKTPTYRGIDLDELERAAAEVEAAAKEIQKTTRKLTIDDLELGDYIDHGAINVVSRVTLPDWWWEQERANHEDKSTPLSTAKNSKYVVKLAAGDWRVELAKRECKALQKLNKKKQKVRELNIMPTLMIGPCNFTNPFHTDQQRPIPSSFPDKYEKQLRTEPEIVAIVVPFYDHHFLSKPSKWVENLDDVRYFLQTLLQTLAYAHSVGINNMDISGSNVKVDMYGRALILDWNANQANGQPIYDPLANTWITAPEGLLEQTGLDSPKNVLQESISGMDIWSVGVMLTNLVFDPCFFVNPRGLGLHHSQIPEDQQRTEFPKHYGLIKEMLMRLGGETRIPVGEGVFLDLAKLVGLSRPKVWKRKFDLPLYTTNSTCQETDFEMLEDASKDDLEQLHSVLKTIFKISPLNRPTAQDLLKHPFFQDKPKRKVVKPQPWNKEEVIYDLSLADLEVGDFIGNGMINIAAFVEFPDWWYRQHNVDKEKQKYVIKMAPGDKWYTSQGDRECDVLEKMNKNKTLARKHNILPNVFCMRRARNPFFRNPDRQLPPSFSFKHQKRLRKEHKMSAVVIPFFNLQRAEDYCEDLDDVRLFISSLLETLNYSHSLAINNFDLSSSNVKISPKGRAVVMDWNANKANGQDMYDPTANTKITAPEGLLEYGLTEEDRILQTSISAMDIWSVGTMLADLVFAPCWWISRDDIDVKHPNGIYHYDYIRAILMEIGGESVIPIGNNKTLDLANLVGLNRSDLLSRKFNLPIFDEDDRCKTKDFPMLKGVPKEEVDLVYSFLETSMKIALQERPTASALLKHPFLSTEKTKSSKAAKRVEGKSNAELAKIIADVPMQYLDASVEEYTAAEKKKVRELTVNDIEIGEFIGNGAINMVAVAILPDWWYKQKKINKNVLFVVKLAAGSDWLTKQADRECYVLEILSRDKKKAEEFGIIQTIFMSKKVPNPFRKKHIPSKFPKHMVKRLRNAKTVVAIVQPYMDLDYIHDLKQFNDIRYFIRSLLRVLDYAHSLGVNNFDLSDSNVRVDDDGEAVVMDWNANKKQGEDIFDPVANLWLTAPEGMIEHGPRGETIRQTSISAMDIWSVGIMLIFLMYQPCQWVNPEVSYLYDKYPRNYHLLREVVKNVGGETIIPIGNHQEMDLAELVGLRREDLLKKKWKMPLYDAEQDDTCDETDTDSYLKQYGAKSKDLEDMHHFLESMMKLSPAERPDAATLLKHPFMIFSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4B0</accession>
    <name>A0AAD2G4B0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4B0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="486" mass="55138" checksum="F53292C7E92E9E78" modified="2024-05-29" version="1">MRIHPSAAASMLRGDDRNNVNSLKLDDTIQQLAANAFSGNKMLMEVSLPQMLKVIGPEAFLNCSLLSKVRIPMTCKKIGVRAFLGCCSLQDVFLPVGLTCIREETFSRCSKLKTMAVPWAVTVIEHGAFSYCTALLSIELPKGLKKIESRAFAHCEQLKNIEIPKSVNRLGDHAFAHCERSLELRFGVNIEALDRRFDDLPLHKVCYYQAHYTTAAKQKQLEKAIRMDGPAGRRKRGGGVFSLCQKADALPIHEYDLDNLDTGDFFYAGGCFVDSFGMTPLHILVLSARPCMSICETVLAHYPSNVTTQDNHGNTPIDYACMVNVPIPMIDGLLRTLQQQLSVFSEEEQRRLKCFVYIANKYDSMDLLLYLTSRYFHARIKALGLDQWKQHVVNEIEIIATLPHATLREGHLERIDDCLRQFEQKEALSLLELALWKARMQSEYRRRLPGPSWRRTCQIQSGAEIVIPLILSYLVVVDEEHDHYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4H2</accession>
    <name>A0AAD2G4H2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS19646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4H2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1962356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50412" checksum="E20979DA1D4FF757" modified="2024-05-29" version="1">MAEEYGFEYVYIPTLTQQKVISVIGIPTAILSVAGSSLIIHHVLQNSKKTPYRRILLALSCCDIIATFGYIMQPFFVPTGYFNSYVWAFGNKTTCSVLGALTQFAFASHFYGAFLSFYFVSTIRYGMREDAFSKKYERWLHLFIVIWSVGTSVAGLVMDIFRANVLGPGCWVNTFPDECIPEEGCNVELIGWVFGGLPSLFCFIAIIVNNLILYCFVRQTVKEGEKKALQNESRLAMYNSTRSGMDASVEEVSLAGASTRSVGTRSVLRSSEKQLQRVRDVGKQSFLYVSAFFLCYIWSLVKHGLDGQNFDEIEGSGAYFLPLLILQAIFLPAQGFFNAIVYFRPKYMQAKRKYKDQSFIWYCRRSIIGEKLKPAGTNFHTQSADTLGGPTRSKRITFAGELTSSYSNSMAPIPETLRIPQEGAGRAALPSMLESTTESMFETSTEEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5Y6</accession>
    <name>A0AAD2G5Y6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5Y6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03407">
        <property type="entry name" value="SPFH_like_u4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF31">
        <property type="entry name" value="HYPERSENSITIVE-INDUCED RESPONSE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="1">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="32301" checksum="F3DCD08BCB45D1C4" modified="2024-05-29" version="1">MCVPCFFTISTSEVGIVETWGKYSRSVQPGLGFVMCPMESLVGRLSFRVQQLDVRVETKTLDNVFLTAVVSVQYQVLRENILEAFYALTNPAQQITAHVYDVMRSQLPTLELDAVFEAKDDLAAAVKEALSQTMEKYGYQILNALITDLDPDQRVKNAMNEINSSKRLKYAVAERAEGDKILQVKSAEAEAEAKYLSGVGVAKQRKAIVDGLRSSIVDFHDNIDGTSTKEVMDLLLLTQYFDMVQGVGTAPHCRTTFVPTSRNMGDDMRNSLLQANAATKTGRYDDRVMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G620</accession>
    <name>A0AAD2G620_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS20594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G620"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1964361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="382" mass="41094" checksum="55FD41479DFC4257" modified="2024-05-29" version="1">MEILVTLEPRDDPNEIIQSGLMQRKPLELRSTGATEIDLGRGSTTGIGDNTIGSSVVRIALRSSGIEMGVRATLQRDAVMCKVHVNGLPFPPGQKSAYLNSGDTISLDGLRYEYRVNISELSGSASAPVIDTLGEDLGFDSEDFWSTSSFLGSPHETKSEPGVNVSPTLCIQLSDELQCSICLDIQVNSRTIHPCGHSVCAACITKLSHCPQCRVKVKSHVPNMQLNSLISKLVSIPSLLDADDVKSYHDRAKNAKVFPVVELTSRSGTKRPRNSTGHRMESIPFRPPNGGGQRRTFDFAFGDMDDEFYMPVHLGEAAAAAATARAIASANISSNSRHPRGLSGLQQANRHRSGNALSSSRRSQPQLPSQAGNSVESAISID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6I2</accession>
    <name>A0AAD2G6I2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6I2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042024310" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="453"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="564" mass="61092" checksum="EFFA75B482A978C4" modified="2024-05-29" version="1">MLRLPPIILSCLVLLEVLQSCHGLSSKSATPATLDFATIRLASTGASQLAIVDGGEWSTVQALLQREGRLPKRTYTKRGYMKIVTGKDEEGQRVIGMLHQTSVNGNESSSTTQVFEDSVATIPAKVSDKDAISTYISALSTIHCALPQQKAIGGSTDAAMINRKVVVLGSNPLACFAAEGLASLGLEVSLVSTGNPKVNAKNGAGKVQILKPAVGEDEVGFASHIGEFDSLVDTISNELKGNFLMPTVVGDDDDDAENDEAPFGSSILGLLKSRHNCMRYISTETECQKIVAKAGIFGGPGKADDYCKNVANPGFESKQDYTAIPPPQDIGNSMTALLENGVLFSQSERKKLYAKSDVVRGWSLADFWENTRWPRDASGNADVRFGLPVISYEEEEEETEQAELMARMGDQPSNFERLAARKLNHAEPSGEAPQPAQNNPHVYQINGVSGVNNAIVSTKKNCILFLSARFCQTCKRLDPKYTRLARIEKDNDSPVLFAKAEMGSAWGKQLGRHLHVDAVPAFVLFREGKQFGDAISISDLPSDKIEKALDLLESDKEWDPQIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7E4</accession>
    <name>A0AAD2G7E4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002210">
        <property type="protein sequence ID" value="CAJ1965631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7E4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="187"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="416" mass="46414" checksum="75F747E35CD96990" modified="2024-05-29" version="1">MTKDDNNNLHNYTNAKVQSVEFLTCSEIESSPSLLSKQQSLLLHNLQHYGWSPISILVSSGNKNNNDTTKTGWIRPPTKEAVLQVMKEQDPNDTNSNDSRFTYRTAESGGGIAAEPKESLELKRSDVVLTQYSSSSSSSSLVDEWCWAMSEIAQSVTQLLELPSNTLLAGQEEQTKGTTSDNNCLDLLRVFSYHATPDGPQLGSSPHTDWGSWTIVWQDDVGGLETYSREHQQWEPVPTAKSNVSAASSANDTTCTAAEAYYWHCIVHVGDMASLALRKNSSSTTTDNTAPESLLVEAPTTSSSSYYNYYWPSPEHRVQTSTTQKRASLVYFGYPPANTSIRTIRQRLKDWKSYCRGSPLPLSEYYLLQNQSSSLSSSIDGKGATEGQLQEYFEKLETLSIQEVIKEKWKQVQRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7Q9</accession>
    <name>A0AAD2G7Q9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7Q9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="219" mass="24842" checksum="00479E0011907256" modified="2024-05-29" version="1">MGCCQSVDAVENDSGKEFNALRSKGSTDKSITRDEFAVYIEKKIELWSMLTVNLGLTDEQCKAIATEVAFGLALKAPKDPKQSGKKEALLDDDRLTKDQFHHFRKNYVVDPKGSLEFFHRCVFTAYDENKNGVLERDEVDEFLDIFYKQDSIFKGDHRLPSKKKLKKLVYKELDNNGDGVLDFEEIRILISGKMDFTSTSSSSQKASSKKKSSKKKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G868</accession>
    <name>A0AAD2G868_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G868"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="643" mass="70754" checksum="7371769384A49793" modified="2024-05-29" version="1">MPKKSRSASVGTLAELNTSTDGDDGDDNSVAGSLNLNDLDILSDDEDDILEDGEDVPPPPNSELAKALMSPPEPSPGVFKRKSASSASSTRKSRKSKLKGSKSKSLSAIDYQFKSPKGGDVSEDESITEEAESPSFSSLCSPPETPSSKSNKRRSSKKRFLGLSTALKENGDASSALPMGGEMVSSMRKTRASIINGGDSSRRSKRTVDDSSRRSKRSSSRTKTGGSEDSSRRSKRTSDKDGGSSRRSRRSSRTADSSSSTPARSSSRKKKSKKASKKDKRKSAESNASNTTSATVDMDESWASLVEKDNNTTTTTTAAPMIATKNQPLHEECQSAGVNSMFHNSINFGNFGESGRTSSDSSLDLSEDDDDDDDDNDKDNDDKKVQEKKKELPKYLGHASLTEIDFSLMNDSKDEEDEEKKEELPSIKEEVIKPPPSRRSLQRTPSSRRGLSCGPVRQRSSRGRDEDRPSSKRGFSASPERKAHTAAEAMEVERPLLSCMKGSRGKLLPTKLKHPPHVYFNETLVITPIIPTYELASKRSDLWFRQKDFDKILNRSMAIALRVKEGKKTKKCVRGLEHFLKDKEERYAAWNAVLVEQEIQHLSGNFSDVRISDLYLAASTTCRTEAFDRAKDDSDAVLEYMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8H5</accession>
    <name>A0AAD2G8H5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8H5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="217" mass="24347" checksum="DA5C9502D81D71BB" modified="2024-05-29" version="1">MWNVLENVHSWKKVYFPASVTYIMERAFMGCASLSDVHLVEGLQVIEEGAFADCVSLAAIQIPSTVESVAYEAFSNCQSLICIEISSSSSVELCDGALVGCQSLVNICLPKTNKDEKYSYLESWRFHGCPLLQQQYDCWLLGRMVKARFNVHPIHFKCYHASETTAEELRLAIQSSFGTRKDEDESDLLLMDSFGMTPFHVLLASAKARMDLLLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAD2</accession>
    <name>A0AAD2GAD2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAD2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042082695" evidence="3">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="251" mass="27476" checksum="EAC486DC7131EF31" modified="2024-05-29" version="1">MLLRLCLLLNLTVLGFSFQGTKNTVNVFRLTSKGTALDLSSPLFGEDANEEELFGDSERSIKDGEDMAKLFYKEMQRRSDSSTLNVDSSVQEISADTPSPPSPAKSTADLRKLIAETGNLDTATDSNAKDDKTSTTSQSADAKFTGQNSLPPQQPFSRSPREAFLSGNTNAGPRSPREVMMEREYELVGRAERNIGIQAVFAVLALTFYIYIGLSGGISSRLDGPDLGADEMLPFEQMIPTQTDRENTVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC94</accession>
    <name>A0AAD2GC94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium-dependent phosphate transport protein 2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS23192</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002380">
        <property type="protein sequence ID" value="CAJ1968343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037997">
        <property type="entry name" value="Na_Pi_symport"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1968343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="61882" checksum="408624D091ADAC97" modified="2024-05-29" version="1">MSEEKPVNSRKDRPTGSMHVGDADFDVNDPAYEMDATWGEVCKACCVRSPVEWAMAFGGLVAVFFFLYFFLVGLDLLGNGAKVMGGCAAGALFGDDMNPIAGLMVGIVATVLLQSSSTTTSIVVSLVGADSVTVKQGIFMIMGANIGTSVTNTIVAMGHLGDGDQLERAFAGATVHDMFNFLSVAILLPVEAATGYLFYLTEALVKNFKAQDGEKWEGPVKKLVSPLASRIIIVNKKVAGDIASGKKVCDDYYPNNGTLACDDYNDPLTCSSGLLSCDSKADTPYCPAFFDPEATESVDRTSGVCAFIIGLILLFICLFALVKILQRLMMGASTRVLYKATNINGYLAILIGAGITILVQSSSITTSVLTPLVGVGALRLEQMLPLTLGANIGTTVTGLLAALLGNKNGMQVALAHLFFNITGIAIWYPVPFMRNIPLNAARALGRSTRLFRGFPIIYIAVAFIAMPLIFLGISYLFSDGNSGLTALGSIIVVVLAVVLIYTGYFCKYQGGSEKCTECLVSREKRNVAVRDLPDDMEWLKAKVRELSEHTGLPIDEEEEAADVEAEIPAKEAADEASDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCI5</accession>
    <name>A0AAD2GCI5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002398">
        <property type="protein sequence ID" value="CAJ1968658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="148" mass="16569" checksum="468BD592B78EAD4E" modified="2024-05-29" version="1" fragment="single">LEACKDLTKKDLTTDLAKDLTKALTKGLTKGDLSKDLTKEVTKELIIELTKELNIDLTQALTKDLNKDISSILDLTKELAKELTKELIKELTTELTKELNTELTKELTKELTKELTKELTKELTKGLKEISPKTSPKNSLKNSLKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDP9</accession>
    <name>A0AAD2GDP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS24443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002513">
        <property type="protein sequence ID" value="CAJ1970425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="522"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1970425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="966" mass="102403" checksum="F11C3D90CE0EEF6A" modified="2024-05-29" version="1">MSSGNDEMLLVGADEKAKDRSSRRDRKSGTSSRRDKDRDRVNKDRDRGNKDRDKERRSKGSKKSRSSDKSSNSRSHRSSSTRSPTRNSNKERTTSSNDKLIFGSDQDAKAKAKAASGGQRAVKPGVERTTTDNNCDNLLFGTDQDSKAKAKAAKQGRAVKPGVERTTADNNSDTLLFGTDKDAKTKAKASGAGRAITPGVVAHHHVEESEASRNDRSSRPSRATGIAAIATVGDIDSLAIPNDPLETAGPEETSKKRKSKQEKNEEESKKKKRWIMICLCLLFLIIAIVVGVIFGTRGSNDDDISTTSESPTGAPSVVQLYDPPSTEDCVIVAQNRTTSAQREELDQFDFGLTVEVTLDTQDDMTENEITALSEAIQKKLVPLLLGCPGVVSRRILGQEGGPSTIRGVIQNQRSLAIGGLLGENRFVIADAFVWGSKMEGACSEANSSAQCHKVFVELSVFLKGDIRLLDVIDLLYEVEGELKANNEENDNNLKDPLEMGSPFLVVRLAEGKSISLLTPTAAPSQLASSSPSAVPSLTPSNLGPMEPTAALPTIMPVVGGTPLPTDKEGEGGGEDNLQPTEMPVDGSSPSSAPSQSPSKSPSESPSEIPSLAPASGPTPPPTPGPTGFPSVTPSLQPSSKPTLSPTLAPVAGPSPPPTSSPTIAPTVSPTPPPTVTASKAPTSKAPTSKPTSQPTMSPSSNPSPPPTKNPSPAPSAKPSMVASALPTMKPSMLPSVSPSMKPSKSTACFETNDELRNAVDILLSSNLRPGISQGKKENVKARYGPIGDWCFEATVTSMENLFKDRGAFNEDISKWDVSTMTNMAGMFSNAVTLFNGASNFNQDLSSWDVSSVTDMSGIFQGTFSFNQDLSSWDVSSVTNMSGMFRGALSFNQDLSSWNVSSVTDMSGILGRASSFNQNLCSWGSRLPSNDVSGNFAFVGAISCPSQSNPNLSSNPRGPFCHRCSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGY0</accession>
    <name>A0AAD2JGY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGY0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11530">
        <property type="entry name" value="NTP-PPase_DR2231_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3420.10">
        <property type="entry name" value="putative ntp pyrophosphohydrolase like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033653">
        <property type="entry name" value="NTP-PPase_DR2231-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023292">
        <property type="entry name" value="NTP_PyroPHydrolase-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="414" mass="46090" checksum="6CD8DFAF9C27C8F3" modified="2024-05-29" version="1">MIFRKRQHAIYQEPNVLESVAQYHHLFRLPILSSPTLPSTERHQLQVSLLREEIEGLKTAIVESKSDLVPAANAFANLQYAIGRAVLEFGMGGLFLSMFDEVHRAHMSKICNSRSEAEATQRFHRSKKGIESVIETVVPSLGPEDAATQSKWLVLRSKDHKMLKSVKYAPANLSIIVTRAMEAAAQSASSSDSCSSHQSLPLFFLMASPGALSSAAEHHAALNGSMAPSTTPKLPNKERCQWRLSILESKLKELENALAGEESVSDGSDDHKETLIRVAHCLTNMQYSLSASVLEFGMASLFQSIFDEVHRSRMSEACETVEEAQETIQHYLKEQERNQEPAPSVPTGTIMESPEEDDEDEDDDSESSDYYYRQQQIQHGGMKWLVYQQGKNKVLKSVKHTPANLSGILIQSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJD0</accession>
    <name>A0AAD2JJD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">O-GlcNAc transferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS15954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001900">
        <property type="protein sequence ID" value="CAJ1955854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="6">
        <location>
            <begin position="268"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="6">
        <location>
            <begin position="549"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="6">
        <location>
            <begin position="647"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1955854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="806" mass="91405" checksum="C77D7DD4378DD1BE" modified="2024-05-29" version="1">MRAIPPRCIFCFKLRFAFLLAVSSIFFHASIGAYELETPYSITLDGPDALAEGQRLFAEGNFDRAAIYFWRAVLLQEQNTDAYSVEDAFSGFIQSYSVQDRTADGFVYIAKESLHRGQKEMAETYLQQALAIDSNNEGALEFQRKLKGGGREKVDNSRRKTRENKFQPNYGTPEADRPLDGKTPEELYEYGATLFSRRNYEHCADVFELSCKRSNYELGASCSNAVYCRHMIMDWGFNGTDFDGDLSRLETITKMEKDSYRQGDLDSFSWQRAASVHPHMMLGYPLDPMLKRYTAESVAFLDETMARVSDDGSIKALPEDLPFDHTKSLAEYVTEASKPGFRLKVGFVGSGFNSKAVLYLSQDIFRFYDRSKIEMHIFSVGPADSAQFIKVGMRGVDWRERVKAYVDHFHDVQDIKMDHIALARYVNQLGIHILVEWDGYARQGERAQGLMALRPSPIQVLHQEFIGTSGAKYVDYLFSDEIASPPHLSHLYTEKIIYLPNHFFSKGHAVQQEVKDPTYEYVPAEFPYKIGTGSPEENRCMGSGVKKPTFVFCNFNKFLKNNPETVRSWIRILREVPGSILCLLENPTSGVNYLRRFVHEASGEPTTFVDPTTKAKVPTFVPKDGDSLNERIHFLKWERNPFDHQQRNQDFCHVMLDSFPYNGHTVAQDALYGGVPIVTRSDGDDMSSRVTTSANVILGLEELNAYGGTTDYENIAISLGANQTKYKELRKRLIDTALQRNPMHPYWDAPRYAKNLQQGLLLAYDKFLSGQPPDHITVLESNEAARGTYDGSLDTNSPDNDIGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLF0</accession>
    <name>A0AAD2JLF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLF0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="35011" checksum="655B182193DE9384" modified="2024-05-29" version="1">MTKQPELKLIKTLWGIDDPLSPELLKSIKEEGYHGIEVIRLAWTFDKDLLVKSLNESGLAVVCQIHTSGGYLKDDEYIYCGAYDVASHQEDLKKQLLECKELIDIVNVGGFINIHGGLDAWSKSEALEFLEFSLKEIEQTVPETMVTFETHRQRLFGSPFQTRDLLSSPSLAKLKLNADLSHWYCACERVFNPNEDRDKIWWPELIKTICGHCEYIHARFGWAQGPQMSDPSAKECDVERTLQLQVWKQLMQEQLNRNPSPVSIYASPEFGPPPYMPVKPHSQEPVASLPDAVSYTKKALEELFVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMD7</accession>
    <name>A0AAD2JMD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002182">
        <property type="protein sequence ID" value="CAJ1964412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="344"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="815" mass="93804" checksum="451D84D425286587" modified="2024-05-29" version="1">MRRDPQRSPKQTKEEKISHTQVPESSGTETPTSEPIDERGHLQAKRHELSTPTSETIDERGHLKAQSRQLSITERNGQDRLAQTGGMGNPRDTSRNVLPQRENGKPSPRDTSLLPQRENRRDNGKDLLPQRESHRDTSSLLPKLSHQTQSREMRENRRTTSSNSLPPSSRKAEGQTQGREMRESQRDTSQNLLPQLSRKAEGPTAPLLDSGTFKHPALQREDNVGTCTIQTLKTHKSLSQKRKRGRDDREENTASTLDQKRLEFELTLRSYRTVIAREVHAEELVDKCITANPMAFAATLADEDTMYLHQAKKEKDWIHFHTAMVKEIEDHTKGGHWEIVPRKSMPQGHKAMRGVWSMKRKRRVGTGEIYKWKARLCIDGSSQEKGVNYWDTYSPVVAWETIRSLLTLALMNGWTTRQIDFVLAFPQAEVECPMYMEIPRECYVDGSEYNEQNVLLLKKNLYGAKQAGKVWFDFLRKGLKDIGFKQSKVDKAVFYKGETIFIVYVDDAILMGPNGREINDVIKRLGQKYKLRDEGDLNEYLGIKMTKTSEGRELTQPALIQRILETVNIDLDRRARREVRTPANKVLHKDEGGLTRQLHWDYRSVIGMLNWLARSTRPELIFAVSQVGRFMAFSKRSHKDAVMRICCYLRDTRDKGMFMKPRSEKGFEVYADADFAGGFNKHSAEDPATAKSRTAYHIMFNNCLIYSHSKMQTEIALSTMEAEYICLSQALRTVLVLIRFFKELAKRIKSFNYTKPIFKCKAFEDNNGAIELATADKLRPRTKHMNIKYHHFKKSVRKGEVSIQKIDTKDQLADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNY3</accession>
    <name>A0AAD2JNY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002372">
        <property type="protein sequence ID" value="CAJ1968257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNY3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="16699" checksum="F8E9BE3B0F54E7CC" modified="2024-05-29" version="1">MLAPLEDQHAHVAHLKSIAKKWAEQVRLGHLHKYDVIPLIKTTVMKSLEYPMVLTTLDAATWVSIMSPVLQVCLPKAGICRSFPRDMVLAPLKFQGLGIPHPFGTQVSKHIEVLLRHLSHRTKTGAYMEAAVQEHQLETGTSFGLFQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPX5</accession>
    <name>A0AAD2JPX5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS23689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPX5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF445">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="152"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1969400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="433" mass="49711" checksum="C136171C63BB396A" modified="2024-05-29" version="1">MISPVPLVLFVISYLIFCAIVLRYCFFADPESSEMAYFVQIVLPTKLWNRSHKLFGDSIMKVMHKISELFMVFVYLFVVLGCWCIVFFHVYPFIDESNSVSNIHKYIGYCVFVACFGSWIVTHKSTPGFITPKTFKRYDHYAYDPLLFPPGRRCQSTNIIKIPRSKFDRIKYKANIPRYDHFCGWVYNTIGEENYRWFLLFLAVHVVMCVYGSVVCFLLFRGEIREKQLLELTFFDRATGESVKSTWFIVVQFLFAQETAVCSVMIVMAVMAIALGGFLGYHVYITSTNQTTNEDGKWTDVQRWYKKEKKRWDEAVAAGLVKPGGTEEPPKEKKEPVVGDGDVTCTGASTTPTEPQEETSPDDEYFDPGPPPKNLHNKGFRENWMEVLFPISLRKDALKHGGYSRPPPGAARKKQGKDMPRKPAPPQQKNKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUR5</accession>
    <name>A0AAD2PUR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS13012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="294"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1951314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="491" mass="55218" checksum="92F8F19670EA825F" modified="2024-05-29" version="1">MEDLDDLVAMIPHPSCKTTLQDGRKVEICTREGAKNAFLRDKTSKNCDFISSTLKKIKKICSKKRLNPSDKGKIPETEIRFWLEYVIDDIKELATKRTWIQSGTLDAVEASSLLCCTNMFQKHAVPVAFAFGEGGFFSILADFVKACKGNGRGLPSNFIAGWILAIVDAAFGISKTRFDNQWSAERAFKKLEASGILAECLRCMTVPQQGFIPWESEGDRIVKALVSCPSVLRKYFKKGDPCGNVVLAILEGKDGHGKIPVKVTKQLQSLVLSLQSIEPAGSDVFAEQYQLSRCGHCGKMTEVPLMTCGRCKSYYYCTKECSFFSFCLFPFVTNPLFFIADWKKHKKSCKPLSEKNKKKEEIAREMVVKFFGKHGERIHSKMIEECQRKGLKTHNMAIELDFMPNNNGIIPALSDDSTSNFKITPIREITNPRRPRTKHPWLSSLDKVPYDEMINHLRANDSGGRKNRKGFFLVLFCYAGGVGSSDIALYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVG7</accession>
    <name>A0AAD2PVG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS15622</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="328"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1955177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="412" mass="44744" checksum="F488EA36CF4C7927" modified="2024-05-29" version="1">MSTVSARFMNSAFAKIHRTGGRRSFASSENLVKTSLNELHKELGGDMVPFAGYELPVLYKGENGGVMKEHLWCRDDGKAALFDVSHMGQIRWHGKDRADFLEKIVVGDIKGLPTGSGCLSLVTNEKGGIIDDTVITNAGDYIYMVVNGATKFGDMKHFEEQMAAFDGDVTMEYLEDSMQLLAIQGPGAAEALKKIVPGDLDLSKMAFMTGTNTTLDGIEDCRVTRCGYTGEDGFEIAMPAEHAVSIASKLLEDPSVNPTGLGARDSLRLEAGLCLYGNDLNENINPVQGALAWTLGGPGSRRRTDQGFLGAEHFLTPEGKLRKQENKRVGIKGMKAPAREHAEIYDVTGENKIGEVSSGTYSPCLKAPIAMGYVSASNAKVGTEVQLKIRNKMQKATITKMPFVEARYYRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW39</accession>
    <name>A0AAD2PW39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS17643</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="520"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="750"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1959222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1137" mass="127879" checksum="6D0E5DDE3813198B" modified="2024-05-29" version="1">MKRQISTFEDNSNVQHDDNESLAATSFVTGTSVVGSDDSDEGVPAKHITIQGQNAVRFSKVLVFFVLFLAAAAVATVTYILIINEEKTEFKSQFSGAASEIVTVARKNADQIFATMNALSVSIASSAAATNSSWPFVRVPNWSLTIESLSTLIGGEAPIIAFSPIVEESQRGMWSAYSMKEAGNWYAESISNQKKNYSVELLMNGTLPFIHYYDVQNNFMPTPVRGLATTLPAWEQYPLITGHRNTMYTNYDMLQFPQVATLFDITNATRRPSMDFNTDLREAANSIMQPIFEGVDSKSKDSKMVGVVWLTMKWLDYFQNLLVEGVDGIIVVLRSSCSRVRYESVNASTQEPSETVVSYLINGPNAEYLGEFDAHDSQYDALEVTKVLVDLDVDESKIPDGNCIPKLTLHLYPTEEFESRYLSDKSLYYTIAVVSIFAFTSMVFILYDFFVGRRQRTVMDRIIKQDKIVSDVFPTAIRERLYDAQKQRPAQDDLMDPLDFEGQTNDMTEAPLADLFPNTTVMFADIAGFTAWSSAREPSQVFILLETIYGAFDKLAYRYGVFKVETVGDCYVAVGGLPEPDKDHMVAVARFARGCMKKMKEVTAKLEMRLGPDTSDLNLRIGMHSGQVTAGVLRGERSRFQLFGDTMNTASRMESSGSPKQIQMSQTTANLLIEAGWSRLIRPRNHKIHVKGKGEMQTYWLLNSNDDSSEKNISSEASDTVDTEHSANLDEDVDIGIAETTKQERLVEWTVEIMGSLLQQVMSSRSNGYKDPGSVALKEQTIGSDKTVLDEFVPIITLKRFGSEELQERKQGSPQSSIGENATSQLRDYISNVASMYRENPFHNFEHATHVTASVKKLLMRIVDTDKRNALLRPKEEQSSMELMDLAGHSYGITSDPLTQFAVVFSAIIHDLDHPGVPNTQLLKEDTRTAKLYQKSIAEQNSVDLAWEILMGPEYEDLRACIYESEEELCRFRQLVVNTVLATDIVDKGLQALRKARWETAFAETDLAAAGEDGIESEDRKATIVIEHLIQASDVSHTMQHWHIYKQWNEKFFMECYGAFRSGRADVDPSTNWYKGEIGFFDFYVIPLAKKLHSCGVFGVSSQEYLNYALANRDEWVREGEKLVDDYLEKYESIAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWF4</accession>
    <name>A0AAD2PWF4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS18718</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWF4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010196">
        <property type="term" value="P:nonphotochemical quenching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009644">
        <property type="term" value="P:response to high light intensity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080183">
        <property type="term" value="P:response to photooxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3460.10:FF:000012">
        <property type="entry name" value="Fucoxanthin chlorophyll a/c protein, LI818 clade"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042042881" evidence="10">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1960412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="210" mass="22349" checksum="072643A80E809D9A" modified="2024-05-29" version="1">MKFAATLALLATPAAAFFNKGPAKVAAPVVPAFSVDTIPGAIDPTGLFDPLGFAEKADEATLKRYREAELTHGRVAMLASVGFLVGEAVESKTFLFNGEITGPAITHLAQVNPTLWLILGVGIARAELDRADIGWVEPENTPVDKPGLLRAEYIPGNLGFDPLGLKPEDPEEFFEMQTKELQNGRLAMLAAAGFLAQELVDGKGILEHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXD3</accession>
    <name>A0AAD2PXD3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXD3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="88" mass="9987" checksum="C76AC5CEE3F3E9C4" modified="2024-05-29" version="1">MLLKAKRLYELAYSVHDMDHDPLFQFAVINNIAMIEQMLGNTAVSDDCMDYLVSLFMLLLDQGFHTHFHHVRGFVANLPSNSNFAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY35</accession>
    <name>A0AAD2PY35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY35"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35169">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35169:SF1">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT FE(2+) 2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="318"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="459" mass="51448" checksum="47795379EF9604B2" modified="2024-05-29" version="1">MIKPIAASGIGESELQLILRVIQEAVSLSEWEEYDDRFANINIEFEYDNDSSSVSLHPAPDAVVGTTGRALILSIGDKLNGEGMDEVIQYVVAQAIDQQLYSEEQILLKQPILVSIQQAEDLLTNDTDLQELLDGLVHDQFFMYEMITPLPISAEAARLPESALTPTIQVELDGDFVTDVWSQEQVWDTSSVLIFDNLVSDDLRKGLLDVTLGTTSSEETWDDVGNGPNPERWVRGGLIDIPDEEEEDEAAPIPSTSWGLSDEAIEDICFHHHDAIQEFECILSQLFPQFIVTRLPEAVFGETVSPLTANAPTFKDEFSIHIDGDPNQTPPSPWTDVYGRYPNRIRGKPRFMSCLLYLNDEWEEEWGAQTRFLDLPTDTLYGVTPKPGRCVVMDQDCSHTVVAPNESAGNRPRYSLVWKLILHPRENLQDMTDLAVGRTWPEPTLFGSAKRQEANAIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBD3</accession>
    <name>A0AAD2CBD3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1918992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBD3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1918992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="353" mass="38557" checksum="2FA37930BA6EE505" modified="2024-05-29" version="1">MIRAASKCGTSVHRAIYAFSRTPQASSTTLSSISFSSAAPQTGENDSMALPPNLSFDRKSSFAPKARPVLVAPPQPVDEEGEEEVSAEDSGYESGEEDLSAAVAQLEEDEAPRFVIPLPDRLKATVHGADGSVNGTLWLDETVFGADPIRVDLIKQSVDYIRNKIRGVRKAKSKTISEVSGSGRKVRNQKGTGMARAGHSRPAHWRGGAKAHGPKNTVDYGNVKMNKKARRLAMVSTLSQKLKEGNLIVVDNFNLLSHKTKDLATMLEESYGIGKGGHSALILDHYLEDEDAKDDSYDASFHGVPINLWVASSNIYKIKVASQRYTNVYDILKKDKLIVTLGALEQMESRWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCB1</accession>
    <name>A0AAD2CCB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000058">
        <property type="protein sequence ID" value="CAJ1928725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042256637" evidence="2">
        <location>
            <begin position="22"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1928725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="404" mass="45082" checksum="108685682CB4C779" modified="2024-05-29" version="1">MTKSGCIFLLVSLGLLLQCLAFQVRENNCQSHRLHLLRIQQSDDHIRILSVPSSAVLSSSSSSSSSSSSQIYSSSAGYTSEVSWNPAQASEFLTWNSDDPEKAGKQLAPMIQHWGGNDVGEFLTRMYLGEVNQEEYTISYHPSNVRSPQWLGLGQDGLRFITLFFREALPAKTLEPQEITRFATYFLLKEHKWPSISSIVRKGREVGTTANGSSSSSSNDNDRFETDTFMKQGHAPDLARVFGYLRRERLGDFVADDVIDLIDLPEQPDKNQIIVQLGEFLGHLGIRLTSMEKIMTVEGLALQGCSPGLIARMVSSMEEIGEDVRLASLEKTKALREAAGIPLTTKNPSDRTSKSKEWMNESISEPVKTPYSEIVTKESESLGIDDFEARWLPEELFEEEKASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCI0</accession>
    <name>A0AAD2CCI0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS206</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1896696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCI0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042128787" description="Kinesin-like protein" evidence="11">
        <location>
            <begin position="17"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="471"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="981"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="985"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="565"/>
            <end position="572"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1896696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1001" mass="109920" checksum="A2CDF6B012C804B9" modified="2024-05-29" version="1">MGLVATWLTGIGLSSAVPTFHAAGITTPSALAELDVNHFEALGISDPNDRRKLFYLVQRIKMAVTKEKADAKGETMEEKVEALINGTIDMVEHEDEGATDSEKVRRSKRLAKKTDSPKKEKKDKDSSKKEKSKKEGKKKSKDKGSDAELSPTKKKKKKKAKSTTESEVDDEHANEEKKEESNAINTPRKATVSAAKANAVFNLDDFDDDTREPQHSFVSTPTRSRRAAATPPRPPTAVNTAQDTSSSVPSNPANPSTPTTSRANSPTTADRFMSPRSTSSSPPRESGISPPRARAMSPPKARAPTITSLPKKALQSNLQPPSAAKITSTKSAIPTPTTSRLQAPKSRRPESKLLNPGTSARTGKPLGAIPSATEANMSPLKPLVTDNLPENSPKLASRGGLLSRRNSRQMSRKNSEVSVGSRNKNEGPFVIGGSEARSWESQVTYLREDNNAEHELFCDQYEDEIYEYDMKIRVIVRKRPLSNNEAEKSGGIDVIHPLDYGDFGKVLVYQPKTRVDLTKEIETVPFSYDNVFGESSTNVDIYQRSLRNLIVPFFKGQWSTVFAYGQTGSGKTYTMMGSNMTGINAGTATDDASNLGLYYLAALDIFDMVQRPEYQHLKVQVSLFEIYGGKLFDLLNSRGPVKCLEDSRGKVCFPGLTEHPIDGPDRLMELIELGAQNRSTGTTSRNADSSRSHAVLQLKLRKDIGRKKNVEHGRLNFIDLAGSERGVDTNNCSRATRLEGAEINTSLLALKEVIRALATGGSMQRIPFRGSKLTQVLKDSFIGENSRCCMVACISPAIENCEQTLNTLRYADRVKERDSESGALPASCDEPVRLNIIPKQPAPLSSEEEEKDTCDFGNTSFEEDEELLTEPPMAVNYSMMSTDTRALDDLLATPRQPSAKPDSADPDSNKMQVGQTLIAAHRSVMSSMLGMVKTEMTLVNKVDGDRDGLDEYLSELQALQSTQLDLISNLREALDNYCNAAEGSSPREHFNDDESFEDLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCR0</accession>
    <name>A0AAD2CCR0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000061">
        <property type="protein sequence ID" value="CAJ1928873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="769" mass="86973" checksum="C110F0DBF4CBD11F" modified="2024-05-29" version="1" fragment="single">MTSLDFISILPPLLCGNTSFGGQVVMRSLVGGRDYHDEFQLNRAPALHGQLSQSSTVALVVALTPSPVPLATPALPHSRSLPVTQEAPPPTRYPTVSPASEELVVSDYRYQFFGTSDSTTIMTSHEMMARAQATFPPKLSLALNSPHDLRPFFEAFPKAQLLWILLCEHEFVNFRPLQEPLPQDKDLPAAAVLNRWSRMFTACLLHYDLDIPSAVRFVGGIHTGVHQNWSTLEPLLYRASVDEKVIVELQRTFLLGAPKVCNAESTDENFHDYLGYGDHSTVLQDIIKTKSTVEKDFMRSYTLVANPLLSFFLRHCHFTPIGMVDLNKPYKSPSLIFDSTFHVKYTSMAINDWTTKKTEPPLTFAETFDRFLVSIYNGRISSPDQEIYLGDDDVSGAFRHVKWHPQMVGMHCYRIFGHVFFSTGLTFGDNTCPPNWDTVACARKQLAQYFWNQPDTITAVSGLIPTEIKTTPLPSPSEIRDFTPAEPNSRHRGVLNADGSCKSPLYDHHMDDVLHMEIGKNLMQAVCASIRALYSILGFPHPANGIRDCVSWNKFEETFSHQRKVLGWLVDSRRLTFSLPDYKRDILIDFITSAVTRRQLPICEIAELLGHICTATKACRWMRCSYFNLEHYLRVILKAHYYAMNNSKSPGATTARQSQKERLETQIPSKFCHRLESLVSKHIAQALWGSTKKYNLGTETLRELHVIRSSLQTEQWEIYIPQYIQRDPHFFSDGDASQNAGGAVSQSLGYWFRVMWSPGIRGGATHINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDR9</accession>
    <name>A0AAD2CDR9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000107">
        <property type="protein sequence ID" value="CAJ1930119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="236" mass="24927" checksum="777B33DC2A2C9324" modified="2024-05-29" version="1">MGGNDPDPEVVEENQQQPALAGNADEAAQANQQDGQQANPPVPDLLNNLIAAAAVATNPFNQQGPQQGPQQGPQQGPQQGPQHGPQQGPQQGQNVAGQPQGGTNNAANLLGQLLAHPQGMNLLGQLITSATNPNATNPTTHTPQYGAFPSTSGTTPIDIGTSYGIKQYSKAVDSLYSSCEDKFDLQPARPLNFIERIQTRALEAGWTIIFQVQNSARNNATDDFPQLHGQISIEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEG7</accession>
    <name>A0AAD2CEG7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000202">
        <property type="protein sequence ID" value="CAJ1932031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="454" mass="51287" checksum="DBDDC92DD59BB0EE" modified="2024-05-29" version="1">MIVIIPYPKYEWFQRPCPSSEVTLIVAGMLFVWTAILFHQRVDRIKTKLRGIGPQPDDYQDDHFVGSLRICSLISAYMDHHEDPGFAILRLGTKAILFLGLMQRNFQHGFLIMLAVLFVECSLNTARILLVYQNCKSIDSVQPLADDEAYDITGDNARQLEPTNVQEDLTRPFALAVLVFLTQIVLIGLVLDDTYLTTTRTCFNGTTGCLMLTSLGSYCLYLMGTFMTCVYYVGPTNSYGSKELNPTFWLKLFLMNKNRVMFEWEDLGGSGEERTLELEAKHWTLWVRFAMSFLVNEVGFTMLLYVLPVKVAGQATIMGVVFQALGMVYLVDLDNCTGNVLTLVESTHKNNKESTTNGSHDYGSSYQMDEKQFEAEKQKIIRQAMKDVEAQLQALAHGDQRHHAQKQRKKRSKFTNITSALFLSKYPNTNNRQRQAGGNSEKSPLVLNGGGPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEX3</accession>
    <name>A0AAD2CEX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000069">
        <property type="protein sequence ID" value="CAJ1928992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27746" checksum="E8293A916D894878" modified="2024-05-29" version="1">MSHRRRGVGVGRSGAAKKQFAKKADEMKATSLQSALDTVEKLRVKLQEFAKDHQTEIQDDPAFRQQFLQMCAPLGVDPLVSRRSFWSKTLGVGMGDYYFELAVKIAEVCFATRSKNGGIIAVSEIQEILSRNKKKKVHKGDIPIAVNKLKSLGGGFRIMEIGTTSMIVSVPTELDSDHVQVFSLAESGEGCITTDDIATQLGWNQERADRVMKLLLSEGMAWEDKYHGVSFYWFPSVWKEQRQAELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGB6</accession>
    <name>A0AAD2CGB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS2610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000191">
        <property type="protein sequence ID" value="CAJ1931924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.20:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041998551" description="Ribosome recycling factor domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome recycling factor" evidence="6">
        <location>
            <begin position="60"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1931924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="224" mass="24694" checksum="09BA22FBF8933DCF" modified="2024-05-29" version="1">MYLKQLALLCLTLGSTCAFAPQPHCAFTARPATPLFASEEVEELEMDTEDRMGKSVESAKQNLGTIRTGRASAQILDRVKVDYYGAETPVNQLAGISVPSAQQLTVDPYDKSVIGDIERAIIDADIGLTPMNDGNVIRLNIPALTEDRRKEMLKMCKAIGEEGKVAIRNIRRSSVDAVKKIEKSGDISEDEMKDAQESIQKMTDAKIKEIDEFVAKKEKDVMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGV8</accession>
    <name>A0AAD2CGV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS14858</name>
        <name evidence="8" type="ORF">CYCCA115_LOCUS24156</name>
        <name evidence="5" type="ORF">CYCCA115_LOCUS2878</name>
        <name evidence="6" type="ORF">CYCCA115_LOCUS9684</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001863">
        <property type="protein sequence ID" value="CAJ1954263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002469">
        <property type="protein sequence ID" value="CAJ1970133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="163"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1932521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1945540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1954263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1970133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="339" mass="39523" checksum="D2D106AD8E27D809" modified="2024-05-29" version="1">MAEVLEDPQPRNNDDNAGVDELDEAPVNHVVTPERIQYLGLKLVGYKRKRLQKSTARVNFERFKGFFGLSPVTAAEIYHDMQTTDIEEAKVEGSRIDLRNLLIALHYLLKYPTERDMEARFGFSMYWSRNLAWESIERLRALKHEKIKWEEDLCTDDIWVLTVDGIHCWIQEPKHPVWSQNRRYYSHKYHKAGLMYELGICLSTGRLLWMRGPYPAGTSDITVARTGGLVEELRRRGQKAIGDRGYNGEQKQISTPNAHDNKGVSLFKRRALMRQENFNGMIKRFNVTSHCFRHSEERFELAFEAVCVICQYKVENETPLYDVLIQQVKDQFETNSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHH5</accession>
    <name>A0AAD2CHH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000236">
        <property type="protein sequence ID" value="CAJ1933055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="192" mass="21009" checksum="400770C935A9AFEA" modified="2024-05-29" version="1">MGISDIIDQNNRGVSLLMENDFPNAIQSFALALPLLRTIADSVWDHTICDGDSLDQHMISSADCADQVKPASSAANNGMMIYQVGIRIPPTETIPSIISWVLIFNSALAHHLSAKTRACPAMLKAKQLYRLICDPQGMTQSPLFQYAVINNLGVIEQNFGNASVANQYFEILPSIPDLREDLQAYGTDRVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJE1</accession>
    <name>A0AAD2CJE1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000504">
        <property type="protein sequence ID" value="CAJ1935760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="146" mass="16140" checksum="712AF6253A3369DF" modified="2024-05-29" version="1">MGHSSSGGGRGRVTPQKVKSNTSSTDVKHLFSTKDENNGKARSSYKDAKERVIDYIQASGMKCSEDMVKSIQDGKAIDFNAIAPTLNAPTQTEAVARDTETAQNKILYSAKLNKNMRRSAYFKTNKRTVKSNIMLKFVTKAMDIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJJ6</accession>
    <name>A0AAD2CJJ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000534">
        <property type="protein sequence ID" value="CAJ1935971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJJ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17707" checksum="C37088E5C2ABE9C9" modified="2024-05-29" version="1">MKWMINASFAVHPDFKSHTGGTLSFGGGAAQVMSKKQKLNSRSSMEAELIAVDNVVTMMLWTKLFMEWQGYPIDKNILYQDNKSAILLEENGRKSVGKRSRAINICYFFITDQVEKGNVKIKYCPTDDMITDFMTKPLQGEKFHKFRDLILGPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJT9</accession>
    <name>A0AAD2CJT9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000181">
        <property type="protein sequence ID" value="CAJ1931837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJT9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="73" mass="8468" checksum="79BFC9D1C099EE4A" modified="2024-05-29" version="1">MPTMLLAMSFWIAFLTDFISRLSSLMSSSFRSRAEAVGSNLNFVELTIWAVFWSVVFRSFRFSRAFLSLRNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKW1</accession>
    <name>A0AAD2CKW1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS5740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKW1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="377"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="700"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1937630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="784" mass="86576" checksum="F7D21F7CAA62964C" modified="2024-05-29" version="1">METISVFDDKTNQHQAMLFDDDDQDHLAEDEEASVTLSKKLQDRRRKAKNRRRRRSSARFLNLGTEDDEQEPISSANLGEVYQNAIRMNAENKINAANSWNLNLIDHLDQFVSTNGREEDAGVSSISDNLQKLSLGPDDAGVNFTKASCTLDASVKIYAYRVDDVHLTSYKVLANLNRTETGKNKKKDDNAASAKSKNLNNEATSNNAGKRKVSETETLEQNLANINIAKLDEAFDIDPLFHKMSKTFDEGGAKGLLLANLGVSNNGCNIVFDSTLEERNEMDVREDQANGLAKEVDSVDVISLNQKLEASLEGQPLFLMQLVPQLASLREEYSQLKQDGFVDKLLPSSLRYAAPKEDEIEADKSIHMEAIERSRVSQAGQSLLAKDQEDDPSLNMDDGNSDFVDFGAGNDFGGDDDHDDNLLGDSTIHDGNHRYSSSSFQASYEGSQEPSQAVVLLDAIANGDISGSQSNYEYFNSQALSQIQGNMWAGAAHWKKQAKKSGKKAPTKKKAGDGKRKPSASKSRKKKINIHDLILDLRTPVEDLEDLMRQPPKGKKGVDPLQITKATNTKYSNNDNLLPIDLGLTVQDFDSFFLRPQDKVSSYRGRQAASTLGKQVAFAHGGGNDDVSFGGDSDGPGFDFGGDDEDHDEDGGFIVPELEGVRKIEKIQVGYATKAKKVDVKRLKKDLWEELERSFADKRKVETDSNKPKEVDTSEGEENEERDTPMGAIEGSLSFQSTVKEMQSTQTQSDATLPFFFICVLHLANEKGLALESTGLEDFIIHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNP2</accession>
    <name>A0AAD2CNP2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000787">
        <property type="protein sequence ID" value="CAJ1939397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="17797" checksum="B81048E9545B70CC" modified="2024-05-29" version="1" fragment="single">MACRKRTIREVASSHNSFKQEAESAENSDFARPSNGDGKPEDSCKKHCVAINREHSSALFTPSSMILSPDAVKEAGLKILLETERLVNPQHQSDIARNEDDGNDEHEGENDANNDTSSNKTRQVAAGASLNLPLVPDQFSPHKAWSEQTAKWSYDVLDHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPK5</accession>
    <name>A0AAD2CPK5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1941998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPK5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44192" checksum="78500F33A774C806" modified="2024-05-29" version="1">MAASSTKMGRNDLFTQANSGALFSHLTSLTTVEISKTVEVIGKSFFKQCSTLTNVILHKDAGLKTIDSESFAGCKALININLGDAGPIIEIPEKCFFSCTSLRTVSIPGTATIIRKQAFYGCISLVDVEFQEGVKTIGESSFAKCSGLTTIPLPSSLKVISSKAFENCTSLLGVEIPQDRDLKKIHAKAFAGCWALANISLPYSAIFTHNTFQNCNLFASEGEWDPTECLRMRYDGSPVHNICYDSSSQTSDTVNQLLQVWEELSLSNTKWLEDRLRYDDDLGMNPFHIVVTSVNLKKEILEFLLNRYPKKVLVSGEFNAKTMMDYLLIHSSKEAVPLIQMTLQKVFVTSINDWGMGLIPKWKADLEQHIQSLHVPTAGDHDIQTRRKLVREDTTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQS9</accession>
    <name>A0AAD2CQS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000814">
        <property type="protein sequence ID" value="CAJ1939601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQS9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="63"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="190" mass="22344" checksum="AFB1AEAF7D1EFEBB" modified="2024-05-29" version="1">MMSMDIPNAFIQTLMPDLGDGEDRVILKVTGLMVQYMIDLDPTYRDYVVYENGKRVIYVVILRAIYGMLQALLLWYRNLRASLEEYGFVFNRYDPCIANRMVNGKQLTIRFHVDDVLASHMEQQVLEDFFTWVNEKYGGLKEVTCTRGKVHTYLGMTLDFSKKGKMKIRMDDYVDRMLSEFPVKFKDNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQT0</accession>
    <name>A0AAD2CQT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS7360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000151">
        <property type="entry name" value="histone H2A deubiquitinase MYSM1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF173">
        <property type="entry name" value="MYB-LIKE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="232"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="235"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="365"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1941115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="57191" checksum="F6389D9062CD8E40" modified="2024-05-29" version="1">MPIPFNEKNSGLKDKAEEALTSKSSSAAKPASPNNSIVETSNMAGLTLAPRRQGEVQEHDSFEHRGLRPKLVAATLSQVAILPKKHVVGQNSGHGGGAGSEFPNKNDATSTVSSHHSKPKPYQYSTSLPPAGHLQPQTSRSKSSSVSLTPQQAYRKLPSSSLSAAAASSVTKHQQPNFASLFAAARNNKLQEQQPQQQQQQEDTMSVEKVLPDQQVKSAKKARRKRTPQQQQRGQTSGRWTNQEHQAFLDGLQEFGREWKKVATRIPTRTSAQIRSHAQKYFSKLQREQETIQNLSSPADQGLMMMDHSSSQEDQPKQQAQPPHSIAPSVQKNIERLIADPQAVQREVEHTLRALQERYRQLQAQLQQRQQQQQPQNLLGGPRKPMLLQPPPPVVAAEEEEEEASSTGSRKRSYQDIETSTVASSQQEQEQQKQEASSDDQSSVTTNISASVASLDNEELIALHVLGGALPRNESNTSIADLFAVASVSRRQDSSAPASPASPQSNAIVDASMSSSPKDHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT17</accession>
    <name>A0AAD2CT17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="1">
        <location>
            <begin position="66"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="41382" checksum="D8261F29E41DA91E" modified="2024-05-29" version="1">MMMNESATTHIINDNIDGSFQTFHPQNSFPHSTIDSCGNTISHCGQHEALKKVSIVDCGSAQEMIPNGQPFHIENEYFSGEVMLMIRTPDVDNSAEPKPLGEVPATISNYFKDYKRRFEFQFQIQFKQLPKGPLFLGCETASTIKVPRLTRGLVGLILGMIKRINSGFHYSFGSKHLTDEQIRCGDYEKTHLSFPVEASMDRVVVTKPGSDAPILGQELHESPESVRRRRRMGFGSVDWNTEDTFTMCLWNAYMDWIKWKTMNVPGCRPFPLSNVTGSQPVYLCVYELANVTPHEYRKQEPCHFQKSLRHYARIEFAHEDVTTGGIAPRFNSQNIRNRSCVDTDSELGSEHSIFSECCTGTNDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWY9</accession>
    <name>A0AAD2CWY9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001463">
        <property type="protein sequence ID" value="CAJ1945710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWY9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="101" mass="12214" checksum="60CDC454CEB59EE2" modified="2024-05-29" version="1">MWKHRNDVFHSEDNIVNQQRATALDRRIHEEFDMGLRDLPRNLRPAIRRSRLVEVLRLLLADKEEWVLVISEARRKIRRSLAGRRRVMWELTHPTPRPAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D023</accession>
    <name>A0AAD2D023_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D023"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="56894" checksum="9ABD3E7D04DB8735" modified="2024-05-29" version="1">MHSALSSDGSLAAIVSPAATSRLMIQVYQLSSSSCSLNMTLTHSSPNPLKDLAFCGNAMVVGLLGTSEIVVWDLERGVVANKMMSSSEDQNFLALSGDSDGEKFSILTQHSQKLYVYEYLASSSKLTRKVKSGKFEGDMKDAYMALSKKRIVVQTSGGARVMDRATGKKEGKIKSKNFARIFVCPSDENLLVGVENSGSVAVYNLSTMKKVVSIPQVFSSSTSPLQMIKSSNGKHTLLADHTLHTITGSTAKKLTQATSARPIAMFLIRDQLLALIHQPTGGCSAEWVALEDEDLPSIIKLDEENESKTESKSATKRKAPSEAKILGPGQAGMEIVPPSKKPKASSVDEDENERTEEDELKEMSIAERLQQMSRAMEEEDEDNDDDDDEDDEETPPTTFKPKTATTESLKQLLSQALQSGDDNLLELALGVRDVQVISTTMKELEPAHIVLLVSKLTSRLASTPLRAEQLSTWLSYCLKTGRFQPQNLSALRNLLFERIESFSDLLRLEGRLAMMRDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D0A6</accession>
    <name>A0AAD2D0A6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001378">
        <property type="protein sequence ID" value="CAJ1945359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D0A6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="312" mass="35163" checksum="50F230A0552BC4FD" modified="2024-05-29" version="1" fragment="single">FAREADLILAANLDLRKPSCAPFQAPTHYTRDWQAAKDELVLGKQCPQLQSLIEAMRERTWATRVLTAIYRIPIELPGMLTSAATENFGRLTLLRFLLAVIVTGAQAKKAEDAEPKKPPTKALELSDSESSGDDDDDDSPPTFEWTTIIKKSLVASTPKPVEDKKTSLLTAPKLPEDDDAWIDQLAQMDLTNDRPSPLFVMILPAKEDGCYFVVVRQRYLPLAMNVLDNLPSFLQFHLGESSFPNFIRVIKNWSATDLAYQNRKLHVEWVPSELRSRCIDDPTDDQGPQVRDPMDFLLCMEDPVEILEGTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCR7</accession>
    <name>A0AAD2FCR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000183">
        <property type="protein sequence ID" value="CAJ1931848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCR7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1931848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="139" mass="16167" checksum="47340F5F20FE1CD7" modified="2024-05-29" version="1">MDSLRKILRILQDHGFACNPLKCEFCVQETDWLGYWLTPTGIKPWKKKIKAILRLEPPKSVSELRSFIGTVTFYRDMFPKRSHILAPLTAHIGHNKKKLDWTPKCQKAFDHIKAILSKDAFLAYPDHNQPFHVYCDASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCZ9</accession>
    <name>A0AAD2FCZ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596:SF72">
        <property type="entry name" value="ZINC FINGER PROTEIN MSN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="508" mass="56363" checksum="250B6713B02F87D9" modified="2024-05-29" version="1">MTEMGSQSAVEDELERILRASGIESSPVDPSSMEFLRQLVVQKKKKKKKKIPTTERRTQLKESPAGQQEGEERNGKPAAAYASNTAADNASHNNSDSNSNNNNNTTSSGALSNSDATMIVEQLKMQTNLILSLQDKIQVLTAKVDDMELRASEDTTTSTTTATRTREQQDASGRVRIIRRDAHPIPPPRDAEAPRRANGIFGNRPVAAAAAVPAAAGPQELQPNVFAWFFETTRLFWVLSRDYVRPIDGALLFKLVFMTTVVMARVSKNSNKNSSKNNKDPKILLVSALLMLGFLFHTRYIQYVYQFLWKQNVPGRVWKGEVNITIPPPDQDDHQDNWNNNNNNNNNNNERENNQPRGPNPVPPRFRRPNQRAQGEAQPAAARRWWQQNDLLVGGVAPIENEHGDAPAAVNPAVAMVQGMYYLVGSFVFSIFPMWNPQGHRQRRPLREERLDADAAADVGGGGGGDNNHNANNGNNDDDPRMIPQVQAPRDAMEAADDSDDDSEGEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEI6</accession>
    <name>A0AAD2FEI6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="215" mass="24837" checksum="D2165D61DCA6DDD1" modified="2024-05-29" version="1">MIRWSKTQQSPNPQDYNFCPPPNTQDDEDENDGFDAISYCSGSVCSRRSSLKPSRWTGNNNNNGSTSSHTRRAMMLAAADDKSARSEVSFDSIGIRQFNMTVGDNPCALGPPVQLDYNDDGSMAETFKIDTFEQKRKPRRSMRELRLSTRQRHNILRKERQLTQKEINEAVLSAQEIRKQRMETHLQSNWEQQWDEFNESAQRKLARYCGWCAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF32</accession>
    <name>A0AAD2FF32_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1900870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF32"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000117">
        <property type="entry name" value="Probable papain cysteine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042265829" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="53"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1900870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="362" mass="39589" checksum="739047554EDB40AF" modified="2024-05-29" version="1">MFLSRALLSTLAATLIAASSAERYNEIKIRDDAIHNSELKSPLPHSYIELGSLPDSFSWADVDGSSYLTHSLNQHVPQYCGSCWAHGSISSLADRIKIARGAQGDDINLSIQFVLNCGSETAGSCHGGYHTSTYEFIKSTGYIPYDTCQPYIACSKESTDGFCSHVDTTCSAGGTCKTCDTFAGMGGACTEIDYFPNATVAEYGLIDFDEDNIEGTCHKIMAEIFARGPVAATINAEPIVKYAGGVYTETGHPTETNHIVAIVGWGACPKTGKKYWIVRNSWGQYWGEMGYMRLEMGKNLLGIEGEIAWATPGSFTVMNFPCYENGENCVKQQEYLDPSMDIVSMQRRLKAHNDAERKNIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH18</accession>
    <name>A0AAD2FH18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH18"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="233" mass="26691" checksum="78FB58937FBBEE89" modified="2024-05-29" version="1">MMNFLRYKATYFGNDKVARDITLDDLNEEDMKWMLSGLFHIQDGRDQSGRVIIYLSNTLLGKCKADTLIRVAYYIWFNILIPIPEVQMKGLVGVYFDASKPGENIAIPGFNSFLTIMSFTCSLPMRYSAAHLCVKGEDKGNLALNNAILGFAMNAYPQSTRLLVEYHDEYDVAPRFKRRKIVTDLRELLNSRGIRFLQQRGSNEWEEVDTKAAELKIAQLFRSIRKKKGPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHN2</accession>
    <name>A0AAD2FHN2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHN2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="172" mass="19888" checksum="C02E87B5F5280C5F" modified="2024-05-29" version="1">MNYKDNLVEKVGGQSQFDFIVIKYCEHITADQSLKLFFKDMEHDSLIELQKEFLSAALLDLPSHITEVAMGRLVVNYQDLWESGLNERHFDTLKAHFIESLRDCWVEENLITLFDQHFDSLRPLFHEVSPNKKQIQEQVVSLHHHISSIAQRSAGGTRTNRLGRIPNGNART</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHP5</accession>
    <name>A0AAD2FHP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="364"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="502"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="588" mass="66687" checksum="728012F49C47F4C2" modified="2024-05-29" version="1">MSTKLQSPDTSACCGSNLQKYSISQHSSNENDVEAILIKGMNDLSFDELQREQEELHGVAAKIDATTDVLLQSLEEHLNRIKKGTVLESAEAKNPSSVHRRDFKMAFIRGNRNDPKSAAEQMIRYYDLKQKLFGQEKLTRDITLQDLNEEDMESLMAGHVQLGSAPDRSGRSIAWAFPGLRTDASPLRPNFYIGMDIISLMEDVSRGTVIVSYQVGDEFKEKGNPNFGEAMEAALAMPCNIAAYHFCFSSRVEAWIAQTAVAVMPPHLRAKTKIHYGSHQECLYHLSSYGIPREAFPLTPNYEMDLTYHRFWLQQCIEKEQMNQSLHANDSSSAKREDRNIHFLKKNVKGETPTENDFLCVGRKVNAKGNERLMSLAVMNADAYDTGSLMKKRMIISSMMEEIWRNGGRFLKLDTTQDQGWIKVDDVEMREKIGQTFRNMRYRRAMMQSKAALNGANSGRNGKPVTISRAHAGLSASTKEELTSGASAVHEAIIVNECKDEDVLFGNFRDHAGNRRLRDLVESIASQYDTASRGDKRRLADQILAQVKESRGRFLKPLDDGRWEIVSDRVASQKIGYHFRNLRRKQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIE1</accession>
    <name>A0AAD2FIE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS3631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001197">
        <property type="entry name" value="Putative ATP-binding cassette family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF134">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="191"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="533"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1934188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="770" mass="85908" checksum="6A3F97544B53D15F" modified="2024-05-29" version="1">MSKWTEETLAEALGGVLLKDIDGLDEDLVSYIAGSLSTQIEEGQSCEEVLADTLSQFLESLDISDDQKELLMKDAEAAISSVESGNVSSSSTAPKKLKQGIVNMSSTLSDQIENESNEILWGSGEKVKANANAQIDAYHDKTSAKDRRKQRQDLQKSRRDLAQMEQAEQNVTKAGVSSMLIPTAKGKERDVLLQNVSVSLDNGKVLLDGVDLKFAYKRRYAVIGENGAGKTTLLQHIAAWKFPGFPTHLRVLHVRQELSTESEETTCLQAVLEADVEVQALRQEEKRLLALLEHQDEGSEDVAAIKDRSLIEKAEGTDDNFNRELERLKEVYERLQLLSADTATSRASMILSGLQFTPEMQISPLKSLSGGWRMRVALAAALLIEPDLLMLDEPTNHLDLEAVIWLERYLQDYPHTAIIVSHDRGFLNAVCTDTIELKHKKLIYWRGNFDMYVKQRNEKQKNEARLYEAYKTKRDHMMEFIEKFRANAKRASIVQSRIKAVEKMDAEAPAPVVMEPVWRFNIPSSAPLSRPIISVNDVYFDYSPKTNDGLNKSESQFLLQKVNFGVDLDSRIAILGKNGEGKTTLLNIIMGLVTPIKGTVAVNSGLRIGHFTQQHVDSFSLGLSAVENLLNKFEGVDEQIVRSFLGKFQIQGNDAIKPMSLLSGGQKSRVAFATLAFKKPHILIIDEGSNHLSMDAADALVEAVKDFKGGVMVVSHDQHFVSNTCTELWVVSQGKATRFNGTFDEYKEQTAKETNKRVEESVKRMAQINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIH2</accession>
    <name>A0AAD2FIH2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS8200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIH2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1942946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="659" mass="73830" checksum="29D9E21BD36ADC2F" modified="2024-05-29" version="1">MGRQQNNSSNNRGQSAQNLLGFHFSTPAPSQQPERNRNRNFQNYNNRRKQNNAYKPSAQDRTSCRRKANTAMFYLHSSSEHQFCLTRQAHSKLSKGKYSFEGSDSPVSWESVRIVKQMLALSSNKVDEEPSCPICLCEFVSARITKCGHCFCLSCLLHHVHANSAAQSNHQVRCPCCAIPIHLEDLKPVMLENVVAPEVQQSITLVKLHREKTCSAPYIPIPGYSKHSHPSCVPCIGDADEKFSRFNYVDSSVYLSLLYQNRTEVEEEAKSLPQNCLDQVFVQMALEMVLKDIQTAEIEAPTEVTFQQDMVKPTSGFYQQLLPDPLLASTHRCSSIGNEKEASENVEMQLAGGKPKRNKLERYAGSLYMDEASTLEYYQAEDGQLVFLCGFNMNCLLADFRRGRPEVSGEELRFPLPDRIKGRVLEIDRKNMTPELQKRLPFLSHLPLYVDFMFVELDLNHILTEQAKQKFKNEFANRRKRRQSKVKAEKKADKAKEREEMQRINERRSRFQTIDPGDDFFQPYVPEEFNLGAADFDATLGGDGSRDILGASPPLSASPRIQAPLQNQELNFMAAARDNGLVVSSTEAFPTLCSVTSIPSSGSNPAPPSWGGAKPLQRQGFPALSSPVKKTPGGKKKGKGGGKGQLLFSTGGQRGTGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK31</accession>
    <name>A0AAD2FK31_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001514">
        <property type="protein sequence ID" value="CAJ1945792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="238" mass="27095" checksum="62897F6D9FB2FE38" modified="2024-05-29" version="1">MSWWERRNSEVDDIAQGYADELIATNDTIATNPKFFSEPCAIYIDNEKVSCLALESVDEAVVLPELMEYWAAKGRLAPEHFRSVDWPIVHRAMKSLKLAKQRFITKHTVGMCGVGKFRKRWGLDSNNRCPLCGLEEDHLHVPRCPSARAKTQWQLLLQELQEWFQSTTTATPIAQFLGALLRNIRTPNNRPRTETPWYRLHGMSSSALTQVCEAQLLSDNQLRSCNESLNALATSGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK65</accession>
    <name>A0AAD2FK65_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001269">
        <property type="protein sequence ID" value="CAJ1944896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK65"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="303" mass="34556" checksum="0458DB9BA7F77870" modified="2024-05-29" version="1">MSASVEQAVEQVAKAIARVENEIKEINEILKNPTISDVDKAYYRQKEDRLRQKESHYLQEKSQYLQEKADIRQKELLLIKRTPIPSIPENQSVNTPFLEDIQKDITAIKESVSKPDRATPQKTPASFGAEELSCLESDGDVHNLDEKEKGDAVLTTEQSGSLLQLDTEHQVVAFLTPFLTAVFQCNRSSNRVLVNSEEYKWLKTSGDEKSTYNQKPDMFICHKSLYQKRDPFDATGDSKLLQMRRSTDIFGQLSHWNLRRFLSVVLEAKKDISNSAFGQTINYAAHLSFEESGSFRSRIFLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKX0</accession>
    <name>A0AAD2FKX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubisco LSMT substrate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS6243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000757">
        <property type="protein sequence ID" value="CAJ1938707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041927046" description="Rubisco LSMT substrate-binding domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Rubisco LSMT substrate-binding" evidence="6">
        <location>
            <begin position="396"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1938707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="558" mass="61238" checksum="02F3DE4A64170AA3" modified="2024-05-29" version="1">MLDHKIVPFHSLLIALSLLVSPNLTAAFQFRLPPPPGAVTSSNLQQDHTLHNTALYAASSRQKRVSSLQEWGKSNDIQTRGVAIESIPGSGLGLQSTQEITAGSLVVTVPSSATLSVTSGSLGGPDDFTVESMFNDRKSFRVLPWYAQFSLYLHKLNTISSVKADDTDLKPWLDSLPTTFDTPIRWDKKQRDEWLQYQHMSESVDRQQEAWTDFYQKVNAALDGTISWDDFLLGCEIARSRAFSGGYTGTIFNPLIYAFTLVLVTVYAGLGLGTLEQAANGAALVFCASVLRDFVIPKLFKTKKYVICPIIDMANHKSAGATANVAYEFFSDAYSLSATPAISTGNEIFISYGERSNDQLLQYYGFVEPNNPNDIYVMPPIREWDIGALEESLGTPFAPGRLGKLERAGLLGKTALEVQADKISEDSSRETTSDDTEDANGNPRGGVVLTRAAGIDLAVLQALRALVSTEAEWQESGEAVGNFAAMVSTENEERARLVARTALEMELQAKPTTLEEDEELLKRSSSSSSSIMEDEERLAVSFRIEKKKILKDSIARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL88</accession>
    <name>A0AAD2FL88_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000841">
        <property type="protein sequence ID" value="CAJ1939753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="116" mass="13173" checksum="B9D6968460D16084" modified="2024-05-29" version="1">MMRLFDFEVPIGIKMDWVSIPYTGRAKYDERSPGVTSPHCFTRRIHAKRVDCTLRSILHPATAKPDFPFAAPATYISDWKLAQQGLLSVKAYGPVKDAILTLISKLQDYYILTEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLZ8</accession>
    <name>A0AAD2FLZ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLZ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="41902" checksum="0D6BE63C228C229B" modified="2024-05-29" version="1">MDIMDAPEETLRNVNEGMQQVMSLVADELMFIFFPEEYAQNNPDYWTFDDRSLLDGRSMASSYYTRDETISTLSNRGWKKVVGDRGPGKKNKGKREAREGSVASKTQTSDQRQDVSEVGGSDKIDENDVMNLFMSETEDVESPPEEERREDASLTNSQPRMEPEEIVDIRQISSGTSANAIDLCDAEEVDGVVVTSADGENEELAANLGESTLQRLQRLRAKREELRQERERYESGIPFNHEPQDDEPEDARPEPQGDYEVDEMNQRMNAIISRDLQHEPVHVQSEANIIDQQREQIQAKVQQLSKVLDQIMIKKLNGEFPDDPSTRAMEAEIRANLLEFQRWWQPSQSDNNIRIAPTPEFQRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMM6</accession>
    <name>A0AAD2FMM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001651">
        <property type="protein sequence ID" value="CAJ1946197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042016129" description="ShKT domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="19796" checksum="7595699B3B67DA14" modified="2024-05-29" version="1">MFPSFNVSLVQLIAILSILLVVLPTQASAKPPAGSKENAKMECLPSDEDMTSFRCLNVPDSMQCINAHPECEDWANKNECKSNPQYMLLQCRKACQSCISLHHGGVTQMAAQEPRRVVQELVESQHYLFRLANDHGIKHLKSCVNKHEMCTEWAVLDECNTNPAFMTLECPLACRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMW3</accession>
    <name>A0AAD2FMW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS10728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="7">
        <location>
            <begin position="1631"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2027"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2037"/>
            <end position="2052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1946586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2330" mass="251331" checksum="5E7F838A248556B2" modified="2024-05-29" version="1">MSEALKTATTDLSSLGRVGHRLAMLDSSAKLQSVLDKLLARLLDRIGKNHKQQQVESDPKLADVLSKMHAKLVEILSHAMKRIRDDRSVKLNCASILSLLLLNDEEISDDKTARKADPFVDPFTLNLSLTFLTLGIPRCDETELKELLPGLIVLHGHYASRVLATDNNATTRSHWHQISHLLIRALEATMEYHNNDKQQVSKKARLSSSSTTTTTTTTLPSEMMAGGTLKPKNGDTTATPVRLFMQTIHQALSKDPIAAAALYDLLLDLLFFQPTAPNSVPPAGCSEAGQQRVLSNKSWVQEMTSPARLSLLKTRMLEWMAPTLSTCLFPEVPARTCTLLLVASGSSQLQQVSNQASLYLKHFRDDAGQHPDRGMTNTSNISLILEILTLCVGSNNALLALSGSSSSSSSVPSSLGLDHSSAANPMPFRRRMVSDSPFAAMMIHMEKILTESPQLFHSSPTIMEQIGSLSLLASSKMLSKLRTSSGLTALKGKPYVSAAQVLNALVVRCLSTMETNTVEIPVQTLNRIQSLMAKVMALACTSLSTTIVGTTSGSTITQTASSEGNQSVRDALYGIICLLSRSTIIVNEPASWLFALGKEQNDEASSYKMNVDTTVLLFACVAKEEQALLPRATAALDAVLAAYCRIANQDESSSAVVSQQGTEQDKGATSTAPPPSAQVDNPWMTLTTTASPDVGMESDVTRTAAAANVDSEQKSQLAKLLLPILWGACLPSQPKPSRLAASRWSSELVRILDLTNACHILCFLTGDKDASVASIARRGLGLDDSLELYVSQEVGGSQENEQEDSHFGEFSLLTDLLLVKTESTGGAWRPNFWEFSPKGKATSISYLLQCLLHDLYGGDDDAIYSYLDAVTKSLSQVSNKGRQYTELLDQSSASLAICMSTSSEARKIMFGANDKLELSMQLDDLQKLALTSSSSRACQDLAAACGSIYGDVEMWGKDKWSDSIVGLMESCLKLLNGSTDGRGHSHGAAFLAATCVQQIRLNPDMTSSDKGWTLASQILTLLGNGTLISDDLISRAYIDSLSVALSSQSRNTDSPQFDARIYDGATAALSGLSAALKKFSGDSNTDVSRAAKATVAIGACLEATIPSSGKQSEKDKLHGARLQCVEVVISLLGSAAYRKDEEIALQAGEALAAYAWVPKSMVWETKSSESWPETLDTEFAKSLPPHQQTIYLLLRGSKLSSNPLKRTAYAPVMLALVARAAAKVNNDPTYGKTALVQELCLHLDDFQSAFISILSDPKSKHLCRESCCLGLAACRSIAKLSDRGNEVNTQLLHAFGQTTNYGSSAMQETQSQAALRRAQESSSENRNGEALAEAIGIEPEVGGAAGVSEASLGAYREMAEAAVALGRPDVLYALLLLSVTHPIWSSKLGRERYGPSALLGENSILGSRTNALELRQALRPHLGKIMPRLLRASHDPNKETREKMQNLWNGLTGGGADARNAISEHLLPIIDSLIKDTSHRLWRARAGATGALAKVLVGRSWTDLGGGPAVLDDDDILSNSVTKTAGIRLLKLWNIAMRSLDDVRAAVRENGETLARGLRSLTVRLCDPSASEDATKEVVDKKSHARDSAAAAATSLRWLIKHGLNQPCAEAAGVAMSCLVGVISVVNHSILQPLVPDLLRSLLLAMSSLEPAALNYFQVRAAGQGTGAGSSFGEIERLRLQVSQTGPLAEAVMKLLEMVPQLDWDVQQAVIPQLNSALRQSSGFTTRAAVADACTTLCNSCPRAFKFTGSNSTNPSVGLLHGFFHGAEREAGTNSRNKMVHAFGSLAALCPGSSVRTLALRACNNYNRATGANHDPAVRLSAAIILRAIAVRAQDQFADGGSNNVWCNKVLPVSFIGMRDTDKKIAQLWKEVWDDGGAAASLAEAVGDFGTVLEEKLLLELVKECRKALADVSWSRRASGASALKELAANQILAPLANRKVLDKTDLDEQRSKRRRIACHLALDSLVNVLSSPRLWSGKNEVTNAAVRIASNWTSAAENESSPLMMKVQSSDDLFVGDDWFKQSHEDTIEEDENEPSETAKQSPQAEPSASDISDMETNAPDDNQEDTVNLVPVNFLGFCRLLLVQGFPSARSCIAVSDEEILPYRAGALGSFKNLLDSLGSTLHDDALRKRVYEITSEKLVSVFNIDFDASKGKSKEPPLVVARSLDCYGASLWRRVGSEDDEVDDVVSAKILLHCLEHPAWTVREAAAMCGVSLVSNSDDSVLCKFDFLSLIESIVTKAMKDRKFWRVRLAGMKLLHSLVTRVPKGARTSTRTGVELKDTTVTSQEILESVLPHKEAIVLLAKRSFSDPEAKVTAVASEVVKDMAWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN92</accession>
    <name>A0AAD2FN92_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS10897</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001718">
        <property type="protein sequence ID" value="CAJ1946914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN92"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042125848" description="Aminotransferase class V domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="46"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1946914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="456" mass="49088" checksum="C90CAB82FB0C192D" modified="2024-05-29" version="1">MAAKLSSLLFFTGGAAATTVVAATGLYLTRRKSNDEGEEEEEEECIYLDYNGTTPIYKEVLEAMMPYLTTHFGNPSSSHKFGQAPRNAIELARTQILQLLGSTEPSNSIWFTGCGTESDNLAIQLALQSSSHTKNKHIVSSNVEHPAVDLYLKYLEKEGIASVTYVPVANDGRVNPQDMVDALQENTILVTLMLANNESGALQPVKAVAQECRKRGILMHTDAAQAAGKVSCELADLGFPDMITIVGHKLGAPKGIAALYVRPGCLEEHKRTIRHIDHGIMLIGGGQEFGRRGGTENTPYMVGLGFASQHAHQHLAHNAAHMEAMRSRLLRNLTERLGTGDRLLVNGPKNAHWRLPNTLSIGFKNVHSGILLAGIGNLVAASAGAACHSSGGGVSSILTAMQIPMEYAQGTLRLSLGPNTRASEIDKASRIIADAVEQQWNSILLVQTGGVFILYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP36</accession>
    <name>A0AAD2FP36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001737">
        <property type="protein sequence ID" value="CAJ1948036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="82527" checksum="E4FE969CBABE3BE5" modified="2024-05-29" version="1">MPPRIGALIKTEKCIRRLMKDKFARGLEIPKTDEEGTKARLLCNPPTLLPIPRTLFQWKPADLSPGGKWYLKRVANLEVAASHYPTPEAVIVDGLNRLRIHRANYTADGPVPKWLQLLWWEFPQEHWEELRMGACQNFVKDPSPCIQPNAPMDATMEEAASAFVDEFMSLGVVRDIDEGRQILTNAPLFVVPKEGQEGQWRVIADMLRGGQNDCVAQDPVYMPQISHIIDEMYTGGYSAVVDLSKFFYNFPTHAEDRPYLGLLHPRTKELVAYYGLAMGAGNSPALACKFGAAFVRLLKERFDVLQGTGRANCYWTGFSEIGFDLKLGYGFILTDDTGGSVLIWAWVNDFLIHGPTYKKTAQALGFFLDTAVDCGEQERAGPGICEYLTGAPHHKAWSRLSLAVAAGILESLTEATPRRLGHTHLRHFHSLVHPPDLGTGAPPYYTTTRLSTHVLHELTWWVSFLKTGRGRFIRASQAATLVPTFGDGSGTGTGGTIHLPGCPFEMWRGKWVPLAYEFPSVWKVLATLKETLLQIKESPKAESVRHTTVLYFTDNSGVYWIATTGSSRSPGLHKLIGEIRLLELELDCMLQVVHVPGLVLISQGTDGLSRGVWMTPFHPNMSSSELNKAIFEPLQFDRTLLWEVFSELTHPTCPWSYVDWNQRWTASLCMGKTTVWFPTPEIAQQLLSFLLNTWIEQSSTSTILFVPRLLESNWRNLSRNIQEKTVLYPHKRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQF8</accession>
    <name>A0AAD2FQF8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQF8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049202">
        <property type="entry name" value="DUF6817"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37391">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37391:SF5">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20680">
        <property type="entry name" value="DUF6817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042270467" description="DUF6817 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6817" evidence="3">
        <location>
            <begin position="85"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1949303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="328" mass="36432" checksum="31B9BBC331DE1BDC" modified="2024-05-29" version="1">MNLHYLLLLCTGLLVLEQSAASSSPSSSSATKTATRNTPSSSSSSIVDDTATPACSQFKAPNARTPTNLKQKWEQDDRNLWKYVEQQVPAVLDHTGTEAFDHHLKGVQAVLRYWGAPDHLANAGLFHSIYGTEGFQGFSLPLAERQAIQQLIGKEAERLCFWFCMVDRSTLDQTVMDWDKPLEDNVQFTLRSRPELGRFALTLNKEEWLDFVELTIADWLEQVEGASTKPSDLFLWKKGEAYAYRRLAYAKMATILAAERPSGRSHHAQEMLAAVMGTEDLETRHLVQLRTPPMSEAAALALEALRASGETIPVDLSPQPHESLACSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR39</accession>
    <name>A0AAD2FR39_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="672" mass="74442" checksum="A4CFC0745BDB2155" modified="2024-05-29" version="1">MSSMIFEAMLATERLYDNSVGVFNDCLTSPKEEAVIANEDFVRHMLDQTTNKSTNIYSYDSDEEKVENDDLDDLVMMIQKRQRKDNGGQEEEKDEETPSLDGTNTTASSENGRLASRMSCNMEQLCAHEQYGLDICLFLFSPNSPLHSPDRQLCDHEDDHDPNPAQDDSVVQENDTNDNDESWFGIECGKMCGGINRAIEADEKTAQTAANSESSREDGSTTIDDSLGEFTYESVEEDDDEQQERGIVPPNALATYLMGLIAENTDEASGGGGGQEHHSKNLGLLECNDRSILSGEIKVPFKELPEPAGRCMTEPSDDDYLMLLQTDPKGTSFCTDDEMSDVDDAGDDESEDSEETDELCPRYPTQATRQALRSSLPPYVPQGEFSPRRQYDYSEHHLEPDGATILSGDEVSSAVESEFSKGNAQQESSNSHTHREADSNSNLENGGKTIYVEILTSADLVHDAGSVSSSLWSHRALLDDDDSILNEDSSWEDYREPDGTKFADIVKYQQQDNDHHATSSSSSFPAAAPTVNEILNDIMSDDDDGDEQEQEQDTTSTIVFSEPFDETQDNFRSSPRQQMRSGMMNDGAHATFELPHIHNQAYKPTQKPKTSLEKRLNLLERLKGLRDSDTHMLCACVQGCGDFADATFFEGAGDEASQEEEGGSTMEQLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR72</accession>
    <name>A0AAD2FR72_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS12099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR72"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF38">
        <property type="entry name" value="DEAD-BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="410"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="735"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1949446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="970" mass="107661" checksum="AEFA6486CC04FAB9" modified="2024-05-29" version="1">MAKRISPSAVIDLTLESDDEQEARLGDVTWRFHGNSTSGRATKRARTLNSSDVLKPGEDVEVVEACVACPTTAIGNPNAGETEIDSEFQVVGTRNELKLPHLRHDCTMHQFLTKAANSDQLRAQNEKHCELCYCYVCDAPVKDCKSWSNVDGVWQNSHCNATDKQNWWVKERGAVKSGSGAASDGVGVGNLASGLMGSTTINRTPNTSNARGSSNHSNLTGSDNTIGGIYAPGNLPTGINQKAHPPCRHCAWHSNNQKAHPPCRHCAWHSNIKDLQKNHGRCIKCGRFTLLSNQQKGYLPKESDYCFGGRKIGFRIVSKDVRRDKKYRESWRKADATDPRWKYDEAAMKTSVFDFRIGKWPRLAAIVHYTSEWEEEKAKQKRRDVIILDNKDDISLLRLLNKVGIGSNRAEKPKIVRGGIIAEEMGLGKHPAPALPIKGSHISCLSSTPIPPPADNALNGLHWNRDLYTETSTDNKLRGSVLSQGTLVICPVSLVGQWIEEAKSKLSNPGLLYPYHGGNRIRDAETLAKNAIVVTTYQVLASDDTYHRKKSSNPDEYCPPLEQIRWWRIICDEGHSLRNAGNQRNKSLSQLVADNKWMVTGTPVSTSMSDLKNQLKLIGVEHVDKIFQSDKRSMRRNDKMSIEIALSDEEREEYDAFESAAKQFYVQFKAGHSRELSKHYLLLSQKLTPLRVACAGGHLPTNPEAGVVAEDDGGGEAKVRKQKEVKYSDFCFTSKLTTLIEQLKQARDTDPTSKSLVFSQFNSTLEWLKQELPAHGFQFRTLAGSMTMKQRAKALHDFQADPPTTIFLLSMRAGNCGINLTQANRVFLMEPGFNPALEKQAIGRVHRLGQKRNVEIIRLIVKDSIETRICEFLETKYRISTNAASKAGSEKGPEEEISAEVEHGVLVGNLASERPRNKIVTSEFDMLFGVKSESEAPDALMPDSTIPDTAAMPDGAISLNFNATSISGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRT1</accession>
    <name>A0AAD2FRT1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001780">
        <property type="protein sequence ID" value="CAJ1951108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRT1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="71430" checksum="7C2D9873EC6DCDB0" modified="2024-05-29" version="1">MRDPKPFLDKLTNEYKFKLKGSGPLEFHLGCDFFRDEQGVLCMSPQRYIDRMVDTYQRMFGQKPKTNVTSPLEKGDHPECDTSELLDEQGVTWYQSLAGQLQWAISLGRLDIATAVMTMLSFRSAPRQGHLDLAKRICGYLLKMKNAAIRFRTGLPDYSDVTEPVYDWADSVYGCPTEQIPTDAPTPLGKSVILTHYVDANLFHCMLTGRSVTGILHMINGTPIDAFSKKQATVETATYGSEFVAARTCVEQIMDLRFTLRYLGVPIQGRSYMFGDNESVVNSSSRPDAKLHKRHVALSFHRVREAVASNMLSFLHIDGVKNPADILSKHWGYQQIWPQLRTLLYWCNLERSPKNNYILSTSLARAMSSLPAGVQRWTTKHVVGMCGVGKFKVRWGAADSAACPCCGDFEDHLHVPRCTAPSASAEWERWTASLDQWLDTQVTDPAIKHAILYLLQGVRDPSLPCSRLVPVCLCRAFLSQQRIGYQGLLEGRLSVHWAALQEQYLQSRGSQRSPTLWVSRLSHQLILLGFHMWEHRNLVQHLEDNVQLRERSRLVNNGIHSQFDVGPTDLPKVVQRMLAVKRQTVLNKPLVDREEWLKLVRMERTAYCCALVPQRHILHRFFHPAQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSE1</accession>
    <name>A0AAD2FSE1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="224" mass="25530" checksum="AB3525D6B2579181" modified="2024-05-29" version="1">MNEYKYFYYRLCVGQQELGEVDRVKWTRSEHESRDVGELRESIYERNRRSYCQHCDARNLSVYAKDTTVESYETEQPLAIDVSLNDSKIQGTPTALPLLVVVSAPTPLIPAANDAIDLVNDGAVANAKHLLNSLFDTTVADNLPNTFAKRQPFRAIRVFLTRRKKRLREFDGHYSNSQDRNSKCPPRGADRSPVNDPRALTPQQQEVAPPRITKVAIVRIEKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSR5</accession>
    <name>A0AAD2FSR5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="746" mass="84821" checksum="ED5F463673694E91" modified="2024-05-29" version="1">MMSNGPRARRTATKRIQQSDGSSASTSTENNNTLHSSIMASETNVVNGMPLPPSAASASLSGTTSVPITNRASSTTILMNGNHTKPNHPSTKRLRRKRKIGQESTISLTRIIVFILVFLSAAWLGWIIAARIFLGSSDDEVMVSKERAFDGNNGLEEAPFSILVIGGSDGSGTRAFCWALQQLGVVLLVDDKHTMDIEASQLFGRTGWPGFVKYVMEQTKGSLDYTWDDLSPDAKKVLKHEVGRFLKHLKLVYENMKIRRAHAEKQDKNHGGSISIPIKAQRIHFAIKAPASMLVLPVLQHVFEYELKFPVAFLHVVRDGRDVSLSQNQSPAQKFFNATFPNDYVQRMDQWKDDLYNVRAMQLWNNWNVQVWNNHHPPGHPNHDQLPSEQLNYNKKYLLVRSEDLVHSKWDVMQALHQFVDSSMPLENLCCQSHEKDKDLGESVHFADTAKNHGPLHPHRHLRKPPRGRGHNWGGFQGNDGGDVTGDTKPVLNLIDWVKESERALKRERQRDPRRAIEDAGSDSYTLDDLMNQGVPLFKRYIEEKQGNMVVKHLEELVKVARGKLDADYKEWKQKFTTRNRSVDAEQQNVFYTRTGNAILDQARNLQHARMALFSRRNEIETDSSYDRPSDKVVKDIMKDLIKRLHMLEDDGVQHAFARGQGGEEGGEGYVDRTVLEKRYGKWQGLLENKPDLSKYLHQEGAQGLEHFGYEPYQDFVYPTLEYQCTQEQLLECKPGEEKQVVPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT44</accession>
    <name>A0AAD2FT44_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="287" mass="31587" checksum="D9675D5CDA817568" modified="2024-05-29" version="1">MVELDSPNNKLASPPKKMKRGKSLLSVCQKVDHALSMVQDDLQATFVGQIDIKGTTSARGNDLGWNFVLLLAATTSKDIGGIVMRLLEGSNDAVSYVASPEQLAMPAQVYGSPKGSESLSAGLYIDNPNTDDHPRWGLGFAIQAVSDQEAKALLTKVQAADPLDEPMRLVKIQDGIKILRGRIPWRSIATPVVAPYLHWERYYDIYKKGGYTSNNGRPDNHEGSVALEIYVTGPSDSFMYIDYIILMGNTSAFFIRTIYYFYYFRNCLRRSPSGTKQGGSGDQPSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTV7</accession>
    <name>A0AAD2FTV7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001816">
        <property type="protein sequence ID" value="CAJ1953080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTV7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="432" mass="48248" checksum="72850CFCA5274333" modified="2024-05-29" version="1">MPTTRHGTTTSPRNNDSPTVPTASVQPASTTTPSVGNAIGKASNAIKPGNTPASLDFAVDTLMQRPLNGPLMQSLQRDGIFCFRDLLLLKDTDLLDLKYDAPITDGSGADTGRTKLTQLDKANRGIINALLGYTYLQWDIFNQSFRSTTRVHNTLNVLDHSYVPASADNKTLFDKQQAFMYDIFVTKLQTNTGKSLVQKYQLTYDAQQIWAKLNDHCTTSVAADTQASSLMTWLTTKKLVKSDWPGKHYAFVLHWLEQARLYNEIASDKMANSQFLLANAIQQTPYLCEIKTSSKLLSAQTGQSLTYPQYVELVTSAAMAHDMAMNEQAVVPATHKALFHDIFSPHNDNMDDYYTQDFDLDVNRQTIEAFQASSYCTTRPQLDNATWQQLDDHARRTWHQIPDQAKATILQNKSAPSGRPSQLEKGEVLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTZ7</accession>
    <name>A0AAD2FTZ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001824">
        <property type="protein sequence ID" value="CAJ1953214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTZ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="409" mass="45478" checksum="98065E3351FFF146" modified="2024-05-29" version="1">MESSTVDDPLLWTICYWIVSALNYGASILCLFVFVSIMSNPKTRTNAFNLYVGFMIFPDSLYAMTMGFLYLSKALGLPLFPPYEVTVYVYFLNFLVNFYSNGVVVHEINKLIQQSNNRQRTQLPDISRVYKQMAAVYLYGVFLATWAILPVSWSLYHIIDQDKGEGDLGSPPGGPVSRLAAIAIAYGSVIIPTGYVIYVSIRVWRKKLLPRKGKTRTLSLFFMRVIIVFVVFYFPNTATTVLQSGMETASGIFWIRVVRGLLAAGQVYTTIYLISRKDDIRRATIEAYNKTFGTVCCKLSYSNGSGAERGSVRVSGFSMGPSEIQRNSQVSTNPLPTSYDHPPASSERNIQSEWEAEDEYDNLNSTGKSVHEDSDKGNNASDGGDDEEGPSDSRVSTINMAGQVNSSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU50</accession>
    <name>A0AAD2FU50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041965443" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17792" checksum="302BC8D0F54F1869" modified="2024-05-29" version="1">MMIHKLIALLLASLLSAPVISFTNQQRSIHSTSLLLPSIQQLERTRGSSPIFSTDPDNDNGLGDDIPLPESSVSTPTSSEPEGTQYPLNVPSPILLATSMILAIVGTGSAFELVNPEPKFGFAQTAVLALFSIPTCFFLFYASVLKATAETEADDKEFMKQRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUQ6</accession>
    <name>A0AAD2FUQ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUQ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="356" mass="42052" checksum="37E1B80E202DE1DE" modified="2024-05-29" version="1">MGSINMDAVLDSSIWQISHQEVKEKATSKDTMHVAVGIHLDGTKDQTGFMDEWEVQLKSLVIHSPIDYHLHIHIIVNQAALQSIRERIQKHSLTEIRSRNYIRMTCYPVDDYEAEWNELIYNSTNKTPFNTAKKIYTIGAYYRLIADRVLPLDLVNVIYMDTDVVLNSNLNALYPYLDSEKHMEWIQIGSTYCSGFMIMNLKEFPRHFWRKMDELARQKTNFAGVHDQYLLRLVRESLPPESTGILPKEWNVHYSDHHRDQSRIVDQEIAYWHFNGIRNQRRGFWHRDYDFMCRMDVSVECPRDSSNETTLERFRQSWPIADFYVRIPWLWVRYMAMSLIPTGEEGYLLAFAVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUW9</accession>
    <name>A0AAD2FUW9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1953011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUW9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="404" mass="44558" checksum="A3B87AF52EE5392A" modified="2024-05-29" version="1">MDTELEKKLLSLDINGQRAEIRSLLLSVETDLDLAADEPYGNADQSIILKSKDRDLCRDLFAIGGDVNATGNAYAFSSFGLNCMAGEFLYVQYWLEEICDGVTQPLSRSGRLRKVLESRETSLRLSPLLLMVSAGKTFPKQQQLRVAKLLLRYGASPDAKDVLGKTVVHYGAGALATPMSMEIADMCIKAAESSDRYGKSAKLEGLEDAAMNGKKGWVGGFDVDSGRRGIYIPELKKEIWVKPSNLRITTKTVEPDPTSNLSGKEAVLEGLKDDKMNGKEGILGKYDPEQERRSIFITELKKQVWAKPVNIRLSKNKPKLTDVKDRFGGVSLHEVVMGNRVDVAEFLLQTHGTSIHTKDADGISPMTMTMGDRILWRTQVGKMISIIARAEAAAGRMEAKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUX1</accession>
    <name>A0AAD2FUX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29115" checksum="5E86B2D79688FCB5" modified="2024-05-29" version="1">MNFQDKTIIITGAGGNFGRDGCIYFAKQGAKIAAFEVNAETLEETAKLVKEQVPGAKILCQPCNVTDAANVKAAVDAVVAEFKTIDMCWNNAGYQGHITPTLQYDPVDFARVMNINVTGMFIVLQAVAKKMEAQGKRDTTYSIVNTASVAGLHGTPAMVAYSSSKAAVLAMTVSCSKDLAPYGIRVNAISPALIGPGFMWDRQNELHASSGSPYYSRDPETVAKNKVNDVPMKRLGTIQEVIQSVAFLLSDQSSYTTGTNLVVDGGVISGLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX79</accession>
    <name>A0AAD2FX79_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001886">
        <property type="protein sequence ID" value="CAJ1955430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX79"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="120" mass="13416" checksum="6C457D1764372CD1" modified="2024-05-29" version="1">MDATYEATSGAEVADKQQHLTEDQCKLLAQALKNTDEIFDGQLGHYKHEKVHLELIENAQPVFSKAYSLLKQHEPAFLKELKHLQEIGVFEGTGPSEWVSDNQLRSCNESLNALATSGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX98</accession>
    <name>A0AAD2FX98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein SMG7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="4">
        <location>
            <begin position="73"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="189"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1955359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="86893" checksum="BA50E9C40311E9C7" modified="2024-05-29" version="1">MPDSQTHRPGVSLKRSPDAYISTKLKEAADLEHKLKASSDDNESVALQHSLCEVFGDILMSDPVAAKKNEISGRLWNVCFYSDISQLRSKISRAKRKKDHDDLKRLTREFKRRCEGGVALYDYLGRHFKTKLLIQADQSQTQDIGTQESSVDDSVEGISKSLEGVVESFFKVYIYLGDLHRYGENFSKAEDCYYNAVKLAPGKGNPYNQLAVVTQTKDPKMSCNALHWYCRSILATHQAFGTSPDNLERLFVANKGYLNEHSRNPKPPIYMPEKRKSSSELVRAQQQAATKSCLAHFVELLHEIIESRKPGDADDKDVDEEATRSRMSDVMASFESLLQATAFSDALLFKIVQICAFVCEICRTTTPISKELSRDFLLMTGATLATRLNSILTRMLEKAKAGSVRFLLPYQILCEYLRQIEESEGKEHDIFWKSFSEIANLVLKFSIRAKVAPNSYVLNGDINVPLKEYQQLRGYRPFNFLYKNYAAGNPFISAEDAVDALDLNPSQEHARNSAADINTTKIARFLAICKEYADNDRFPITFSDDAYSFVEKVAQDEDQDEHIDGADFTGSAPEVCDEDDAGDVVVFRAVEENVSDAFTSKQAQPPLAIPRNPNVANEGESETTHMAPPPEVLPPPAALLPPPGFTAPMHNPVSNQGRNLLPPMPPQQYPHPGVYGHVVQGYHMAPTPPPPPGMAPLQGVPAAEINGHVPFGQAWQVFGGPSNSTQSANPFAATMPIGSFGHAKPASPMFEDQHMTTDGTSLLDSALIDSLFMDDTKTNNPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXY3</accession>
    <name>A0AAD2FXY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001924">
        <property type="protein sequence ID" value="CAJ1956678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXY3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="248" mass="28059" checksum="89B41F66F9D281CE" modified="2024-05-29" version="1">MVAELGQYAHAIGTDSNNSMEPQSIKAIYIEPTKGQRTGHQVLNLNTKKMISRPKVVVLPVTDQRDLETFQDGNQIAGVDDTAQGYLEEAFDQDYEPENEDERDFNLHGQFNDINDSEREELLADADNDVDDMPELTVRFRGNDDYESDDNLGDEGDKEEEPIVAVLNHHQENVDRGTDDIGSLVTDLEDLQEPPEEEIVFEPEMPQVAKVTQSGQNVCASCNVWAEPFSSSKETKRMAFKQEWQFCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYJ0</accession>
    <name>A0AAD2FYJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1957130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="560" mass="62529" checksum="4844ED774DF79E3D" modified="2024-05-29" version="1">MADEKTVLDYFLANVEKHGDRIWMTQPMGKDVVKTFTFKETLAEAKKVAGYINSLDLPEKSQIAICSKNCAWWVIADLGIWMSGHVSVPVFPTLTADTTSFTLEHSEAKLLFVGKLDEKPWLEQKKGIPDSMPTVSFPLSPKDSAKTTWEEAISGASPIETPATRTLDEMATIIYTSGSTGKPKGVMTSFRAMTISTIGMCKLLKVTDKDRYLSYLPVSHGMERWIGECIPMYSGEGIWFAESLATFVADLNRCRPTLFLSVPRLWTKFQAGVFTKMSESKLDTLLMIPLISTLVKKKILKGLGLDKVRIAGSGSAPIPGSLLDWYRRLGLNLQEGYGMTENFNYSHMSRLGRTRPGYVGEAYDDVECRIAEDGEIQVKTPGKMMGYYKNEEATKESLTDDGYVRTGDKGEIDSMGRLKITGRTKEIFKTSKGKYVAPAPIENEFVRHNLIELAMVSGRGQPQPYAIIQLSEGPKGTASKSEEERTKIAAELEKHLASVNGTLEAHEKLSFLAIIKEDWLPENGFLTPTQKIKRAVIEDSYEKHVEGWYGAKKKVVWYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYX1</accession>
    <name>A0AAD2FYX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1957234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="208" mass="22941" checksum="9C9FADBE09807055" modified="2024-05-29" version="1">MVSYNKPNPLATFIKDDLDYFATLEDELFDCEECVATRRSGSSISFSEDVAIQEVTCISDMEISEIDNLWYTQEDFTTMKAECRQLAKSAKSARIKESADICIRGLEEKLNGRKKKINRSEAIGAVLCEQDAQFSYGEQNPEVIAQVYQEFASHCLDEAVEQALRDQEAALAIHDLPSNSSSLSSQGDGCTSSIPSLGKLGGRTMLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G101</accession>
    <name>A0AAD2G101_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G101"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF13">
        <property type="entry name" value="OS03G0201400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="3">
        <location>
            <begin position="400"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1958464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="670" mass="75939" checksum="A8D9452239CDAEF6" modified="2024-05-29" version="1">MFRIAEFLRREKLSLLRRLQSSLKSSVTTSSLSVSRENRIGSERLASLDPFRTHRREQKFAARDNDHREAMKVFLDSLNAALSSSSLQQSEIELGLPTNSLVAETIRTPMNNGKEGKKIGIHPNESFDQTPEVEERTGSNSKIASQNKNVNRLNLLLSRAVRRKNVQKSVTLFEQAVENDQLIEPGLVSKLFFLVSKSDPIAAYENMRYYHLHPDTSETSIDMYRRLCNSVASLDPRQYPQRKMVHFVECLLRDLEEMENDQKAQLLPNLIVSLVRQRSVSIGPYANTLYDYMISNEMEMTPGWLNKLLSSSKYNRQEDLPFHDVLARLISKGFPPHPLTSIPVVHNMFPYTDTQQMRVALQALLDLHASFDEDVDPSSNAAMYEHYKIDRSTLEMISTGAAQKGDPELIMLVWEVLETLGYNPTEHLFENTIVAFACNESALVDAFAAVSAMKEAGFEVSRALIRSVSRAIRSKRWHVTNAFELLTESNQEDLICLENFNIVMSSYAERGDVNDVLRVMQTIRDIDLQPNQDSYAFAMEVLGKDLHRRKSSKDKSLVHKNIEKASSLLASMEEEGVQPSADFVRNYVELLCMGNELNTATELIQDCLATDGMRSVISNKTLYRAAIAHADVGNMDIAKGLAAQTSELIPVLIRKIKSKEQRFLHLKSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1K2</accession>
    <name>A0AAD2G1K2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1K2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND FE-DEPENDENT OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="2">
        <location>
            <begin position="94"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="297" mass="33807" checksum="B5E69731B0C012EE" modified="2024-05-29" version="1">MMNKTSSSMFANSKKQKRVTSFFGSKMPNKRPRSHSKSIQEERSRFGSCPLCSQSFPLHSLESHAALCNGESAEKSTVSPQKPIPKPSSEPIPGLYLYENFISEEEETEILKHLDTESMQWKTSRFNGHQFGKRWGVHCNLRDRRVNAAENTLPDFIQQILVPKLKDLPPVKGCLPNEANAIDYRRKQGHWLKSHVDDRKLSKEPICNLSLAGDCYMTFRNEAMHRNLAVKEQKVLLKRRCLQVLTGSARYDFSHAIANPDLLSDRRVSITMRESPLTVLAPSQSKLNEVSVKKPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1X3</accession>
    <name>A0AAD2G1X3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002020">
        <property type="protein sequence ID" value="CAJ1959773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1X3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="257" mass="29154" checksum="E8EB63DC300AF443" modified="2024-05-29" version="1">MSKSQSSMLVKNLNALVVTHSILVEDVDMDVGAEVTVIIKPLPIHPIQVIKIKELRIKDIATLQDLKATIKDNLLEPVLKPKDALGNKTIKPIDLQTTDLQGIFKTETLKTIIMLNRITIKTEVKPKAQFLLERITTIRKGNASFRLELAPKWAKAECLLLKFSVINILYKANSYNLVNNKKCILLLKTRILQMTCILQWKIKAIIHTMMPLNITITTMKLIDLHSKTILVHSLTIEKIISETKQHAFRQNQPVCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2P1</accession>
    <name>A0AAD2G2P1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">subtilisin</fullName>
            <ecNumber evidence="7">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS18794</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040002065">
        <property type="protein sequence ID" value="CAJ1960577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2P1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042136072" description="subtilisin" evidence="10">
        <location>
            <begin position="22"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="222"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1960577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="649" mass="70413" checksum="2019307CA4109698" modified="2024-05-29" version="1">MNQTQNILLLAFCAIIFSLQAESAVVVVDEVSSSTTTTDEDSNLHGTGWATAAHIPIDGEEEDGETDGDFTFASMYSEEKRRSILVGFDSAENEASFVRNRRQQRSGSAIVEHEYEYTKTVRMEVTEDEYQAMLAAQKAEDKDATGNGILYIEEDVLVRAAFPKPNPQAISQQKPQLEQSQEQSYLRDKTHRKLQERVSYGLDMVQGFDYIPPASEARQCQVKICIVDSGLHVNHYDIPYTRGSPYVDGEEFGLPSNQYWYNPNSRTDHGTGIAGIIAARGGNGAGTLGIVSQGPEASKVCLLNARIFADDDYTTTSGFVLQAAEWCANKGANIINLSLASPAATNSDRYTYQELYNRGILLIAAAGNSGTDEYNYPASLDSVISVGSIGQDRKQSGFSQTNNRIELVAPGHEIYSTSGDDMDFFTGTSFATPYVAGVAAKIWAAHPYCSNRQIREALQKSAQALGTNPVPTSRFGYGLVRARAANEYIQEKMYWPCGDVPVPSPGPTLPPTKQPTRHPTRGPTLGPTFSPQEGVSNPVDLLSSKVTEGDPDAHCQVELTYCDGDFTTLGDLSIQVSAAGVNITTATRVVRICCLGLSCQNMEGHKRGVCVGPNHFSSATTISGGSWWKSSFLVVPLCATARLILFGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G379</accession>
    <name>A0AAD2G379_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G379"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF2">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBA" evidence="2">
        <location>
            <begin position="348"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="505" mass="56887" checksum="B61B710243FDD76F" modified="2024-05-29" version="1">MSTTNYSWAFHDTSTECAICLEPLDDSDYDTTTETTTIKTNNSKMSATIRLVCGHRWRLQCLREQLELARPTFAKRLLLRHKVHGLLVEQLNNDAASLSYSDNDNSNKAKLSNGNNETNQSLLLAWKKVQTSKDPKTKEQVLREALKKYAFYLCSHCKEPYFGGTVECSDEMVEEESSSDTEPRLCMACTPQIVCHSPLEHLGSIVWKCRYCCQPATHVCYGNVHFCNHCHDRNTQRVQQIQVWKQEERLSRRRMGNSKGAKMEPPPPLEPIPCPGKDCTFPKPSLSSSSTGNDGNNNPAVGISNVSTSSSMAEFHSNGSSADCEQVYTCLICQSSDQEQPTRDAPGSDNLLTNTSGQLGLRGWKQLNPRCSWQVEPSDWPLNAETTTNFVSSFAPCLMSQLVDLRRLAAALLLSDHETEPPLFRTHDFAVEVSARYQARTDCPSLFRLEAIAMDQNQQPLQRLRTEALDAPPDHWDRAESVLEYFCLEEVQYVAIVILGKDKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3A3</accession>
    <name>A0AAD2G3A3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3A3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16993" checksum="C859143D09F6894A" modified="2024-05-29" version="1">MVQFGGIASSSSIPRRRKRRKGTIRIPRLKVQNIIIALVVLLILRSFMIQHDGRQGREEGLQELKEGGLSPEEIKNFFPVSMKALKKEKLGQLVHTDEEKRADALKDVRSEVLKKMDSVHLAKRLEKEAELDKENPDFVPTRKLRGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3L1</accession>
    <name>A0AAD2G3L1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS19255</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3L1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050120">
        <property type="entry name" value="Adenine_PRTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11776">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11776:SF7">
        <property type="entry name" value="PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="42"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1961555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="218" mass="24016" checksum="A4599D417A4573CD" modified="2024-05-29" version="1">MSTNNKYAQDGPEAKEIAQYLPYFPFKGIPRFYDIGGFLYEPAIFQKIVDIFVERYSVLQIDVIAGLDARGFVLGPPIALALKKPFVMMRKAGKMPNTICSDDYKTEYGNRSGMTLQKDKITEGQRVLIIDDLVATGGTLSSAISLVKMLKGTVVECACVVELKMFVDPPADSGLPSRTKLFKDLGHDGIPVWGLISEDVLTNEAKLPDGYVDDGEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G417</accession>
    <name>A0AAD2G417_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1962040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G417"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="271" mass="29464" checksum="7C9B6F2220E63986" modified="2024-05-29" version="1">MMIANNGRSSLLSPRSTFQLCMVRNIDLVEAIIFYGKDSLFVADDGNDENDSNLELLLAGVENLVDECIRDETAVLAILPNDNVCNDDSYLSVIPKEITIHRELQTPPNPRDLWTAIHSTQVQPKGFGGSSGFGRKAADPERSPLPKHCVVLCHTEHQCRAARFAGMRVLCLTDNDLADGIMLDDCWESICMDDIATPGSFWLNPPHPKDDEGNAIDIDQVMAFFESSSGGEESEGSNGVPGSASSEYVAAVSEELDDDQLAAMLADIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4Z6</accession>
    <name>A0AAD2G4Z6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protochlorophyllide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS18236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4Z6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042145992" description="Protochlorophyllide reductase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1959817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43394" checksum="B3C9377E1E069F03" modified="2024-05-29" version="1">MISWSSFLIVLTAGMGILISAPQPELDWENEILPRAKQLGQILSSDDPSVDSLPLKGVVVVITGCTSGIGLELSKLLSTKLGATIIGIGRSPNKLQSLRDDGILQQAFVADFTDLNAVATAARQMIDFVPKIDILINNAGLYAPTSWNYPTTKQGYDWTFGVNYLSHFLFTEKLKPMLNESVHPKVVHVTSITSFGVPGTDLLTTAAVSDKGLQAQLQPPLASQPGGNVGFMAFKEFRAYANSKLAQLLHARALARRNPNWRVVSACPQWVGSEIVAKSQTAVVANIFTKLAYPVQGYGLNSILRAVLSTDEEDGKQDFYTNTNIQCMFWLEMFPGFCYNLLPIRDVMGLALGMVILGYQRWFVPGGPAKSATVSYDADLQEDLYEWSLSEVWGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5R6</accession>
    <name>A0AAD2G5R6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5R6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042010240" evidence="2">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="303" mass="33412" checksum="12FFC94638F1B163" modified="2024-05-29" version="1">MKSSSINILLLVAILFCSEVSSQSMLQHFARALRGKHGHHGHHHGENFKNKHHHQHHHGKDHEHKHDEDMMMMMHQDHQHHGGKGDIMGASPPTSSTSNLRGGAGRSSWWASSSSSSSSSSSSSSSSSSSSSSSSSSSQSSPSSDEEEEEEVSTTSGSNSSSDDNGEGINVVQEEIPSLNEGEEEEDNHEIDVVDTEEGEDSQEEIEEEAVTMQEDDAVGSIVEEGVEIMEETLEEVMEDLDEVIEETRTESIEDEDEEEKQANQGMDDYVYAEPVLVREDKETNNMVEVDQKRIFAKFLGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G669</accession>
    <name>A0AAD2G669_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS20335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G669"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="9">
        <location>
            <begin position="240"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1963805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="457" mass="51973" checksum="B803EE65452478B4" modified="2024-05-29" version="1">MLTSSPSRLMLPSQYDDESSRNSRQITQLGFLVMLMVLHTFSGGVDTTNFAFLKNYNSQRDQRSTRPRSLRFIQSQSDIVANSSNATATTTRPAAVVTNHVMYTNFSSSSSTTTSSNTTTTTTTSSSSSCILQPNNPMTKVTHPIPDPPPVVEEGIEEVFCRMHENIQRHFPHAMQQLYRCYSMWRDYPKAKPYLTVPDSDWQQWLYRHPFLNGLMAVFHKQMHMSTIVEEDYSLQMLQAYENSNVTIFQTVVGSDYSIRHVRFLQDIVQKELQLDDGGNEKSRDSCSSGTGSQKKPRIGILNRSHRHNRSIINANEIATAIQRFSRNDTVKVKYFEGSYFEEQVAFFQSVDIVLSPHGAQLAGLALMNAPCGHVVELFPKGYSVPNFFGSLSVESEKNHSYIYMSANSSRFDQAKTRKQRAKARETNFCPSVDMLTDSIRRVADEWRQCCEESNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6H1</accession>
    <name>A0AAD2G6H1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS20700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6H1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01907">
        <property type="entry name" value="WORMGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1964580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="163" mass="18739" checksum="7A67895802AC3F07" modified="2024-05-29" version="1">MVSDMSYSTVSNVIDTWERIRRIKDFESVVGTKLFQKFFALEPEAQRIFGFPDDMDPTSDEVLTNKRFVKHAKYFVQMIDRALSLLGPEVEMLTEILLELGEKHSRYGVKPEFFPSMGRALMEAISCNLGEGEFAEVKTDWIEVYGALSYDMIRGSRMATNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6W4</accession>
    <name>A0AAD2G6W4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS21010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6W4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF4">
        <property type="entry name" value="NEUFERRICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="33"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1965225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="196" mass="22180" checksum="71E8A935A9B068AC" modified="2024-05-29" version="1">MTSRNILFSISLVIGILYFTIIGRSGASERRLVTLEELETKNGENGSLIWLSILGKVYDVTEGKEYYGPGQSYNSLTAADTTVPFVSGTFTKEEAKKDPVELSDSDLTGILEWQKFYSESDKYHLVGKLVDPRYYDEHGKEQPTFVTLLERLEKIKISEEEKKAVKEANKKARLEQAAKQEEANKKAKAEEAKQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G753</accession>
    <name>A0AAD2G753_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G753"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="51"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="308" mass="33739" checksum="DB11097ABB8C5857" modified="2024-05-29" version="1">MLCQISRSKKRRLTSSVHQLLIRSQCSGANATVPLYSEVIPNQNESGSHTVFLHGLLGNGRNLKTFAKQVCKETNSTGYLMDLRGHGKSRLPTTNSDSTASFAVCAQDVAQATESIPVTSIVGHSWGGRMALQYAAKKPSESLERVWLLDTVPGKANSSVEQVIDTVDQVVTNIQNSSSGTMDRKQIVQELTTAGLDQGIAMWLASSFDGSDFGFDLSVVHDILPEFGTQDFYGLLDEILSQNIKVDLVRGGKNQEWNSGPDGMSTLRELEEIQQQYPDKFATHVLPKAGHWVHVDDMKGLVQLFATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7P0</accession>
    <name>A0AAD2G7P0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7P0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041973530" evidence="2">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="128" mass="13566" checksum="BE7306A32333388A" modified="2024-05-29" version="1">MLRLLLALFIAQQIAALAPARSSTFRPAVTVNGARPPAAASAMRASVILRMSDGGDETKAKVSEDGTFYDDEMDSAPVKEGISESMRDRLIREASTGLDADQKQPNVILYVSIAVAILVALGGQGILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7P7</accession>
    <name>A0AAD2G7P7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7P7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042017935" description="Secreted protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="52852" checksum="6E067773CDD2696F" modified="2024-05-29" version="1">MRSIATLLSILALSQHSLNGAVAQTVSIAPSGSPSLSDAPSRSSVPSSNPSGSSSPSSSDVPSIGPSVSPSIAPSGSTAPSALLSQAPSGQPSGSDAPTGLPTKSPTQAPVAFVKENDVCIDAKIVAPNGIHHMVDLTDATPDKGANGGACRGITIGDTPGLWFAVEGTGQTLRASTCHPETQVKVKITLFSTLDSSCNTLSCEGVSLQPDFECSMTTLSSQTDTDKAWRSPSSKVDFPTIPGIKYYLLVQQNSIVETGKVHLSIRPVTAPQHDNCVDALGPLPRDGTMVSQTSLDASITSVIAGYCNLQPSRYPGVWYQFIGNGGKVELNACAFNNFDGFYFSVYEGGDCDGLTCVDDVVEATIENDGECFFRTSAPDQPVTGVQRDKFQAVVSTTDGSRYYVYLHFAKTEQDTVTSEDVRFSILDVDGSSTSAYGTNAIKFRDSQYGMGSYVAGKVNQKNFFEDSSNKKTTGGGGGGSSGIDDVLQNRVAAVASFVSFALMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8R1</accession>
    <name>A0AAD2G8R1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8R1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="1">
        <location>
            <begin position="83"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="584" mass="66510" checksum="24EFE77AEB3B8D70" modified="2024-05-29" version="1">MMHNLAKIATRGLHQFRARDIAFIVHHLFKKNIQNKAIFEAVGEVMLSRFQDFYPKDIGMILCSCSRLGFRAMPFADALADLIMPEMDSYESKDLSSVIYSFGAMREPRMDMLRNAASAAVGISSTFDSRDMTRMLRSFAMAGYWDEELGETMAKQAISIMSTFSTLDVGQLAVAFCQQGKPQRELFFAISKHVTQNCHKMTAEDICNIVYSFTYLNHGCRAFYDEIASAAILIMDTFKPLHLRSIVCSYSKINYFHAQLFEEVAESSILNMDSFTVPYLKQLVRHFSKLQYYHEELMLEAGRQMVDENGKFHVETLLHVLDAFAMLNIKPSMLEDLHIKCKNVIHILETTEELSLVKSLSRLQMEGDCIDKISQKISEDSPDLTNEEIVEVAKVFTIVQYKKTQFWTAIGKEILRRDHTKWTVKQLGVLSSAFGSLSSSLCAEPWSEVVSKCFKMFFIMFQLKESSEITIQDVAAVSSAIPFGKRAGLLPSGFVVQVTRLAISKAPEARPDDVRCILINLSQIDLPISSRRRFLGIYRAIFNEVSVFLNCKDCKKITEVYVEMDQIRDDSTWANNFSFLNITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9N2</accession>
    <name>A0AAD2G9N2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS22502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9N2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="380"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1966916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="583" mass="65719" checksum="0D271A6886BEA066" modified="2024-05-29" version="1">MADNQADQESFGAGPINPTNAIDPRMKKDKHKFLWSRVHLSHDSIVPPPRSGAASVVVQGKLYVFGGYGGGTGRLNDFYAYDFRKNGWEEVKVEGETRPGRRENNGVVISDSSKSIYLFGGYDGTAWLNDLWKYNIKSRRWTCIQESSDQTSDHGEDAGAGQVAESNIIPSRRFGYVSVVHNGKLLVFGGFDGSRWMADMYVFDFRTRKWSEIAAKGNMPSPRSCPAWAKDDTHVYIQGGYDGVERKDDFFACDLSTYTWTQMPSLGVTPSPRYFHSCCLYGHKMYLYGGYSGQTRLADMFVYDFETNHWSEVDCSNGQPPTGRSSLVTQVYENNLYVFGGYDGKKVLSDFYKFKLKPIGVPPMSLVNDFLKLVNQPDTSDVTFIVEGEEVYAHRAILAVRSEYFRALLFNGLLRESVTTDSATKPISIQDVSHSVFLKVLEYLYTDTIQEITLELGMHLLIASEQFMLDRLKALCEDLIRREINVHNAINILVVSHQHNALGLKEIALSFILEHLQERNIQIGLNDLKTEPDLLVEIIQLSSQRVLPPARPPPPNPQRQQHVDMLMNGGPQFGGGDEWNAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9R0</accession>
    <name>A0AAD2G9R0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9R0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042128881" description="Subtilisin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47786" checksum="3D981642692A5F9E" modified="2024-05-29" version="1">MRHLLSILSLGVVTATMPIYGNPNVAAHSRELAIDTIQADSELGTKLLSQARRLDDSGVDMSWVVGYSIKFQGCHHVSQWNDDADENDQVRIQTKRLIRFRLCPSDYCSTSSSGGCSSGYGDYIIDMNSFLDVYFEAVSEQNQYTCQNAYSNCDCQNNGADDYNEEMCYYDCYNAQGVADICMDNNPYDEDGQNQQRFQIQDYADCQETNFNNRRQLDDAGNDQGENQQEDNQDQQDQQQQENQNQYYEENAPEYYIGPYCSEQGGSIYLGLFYDDTCTTFADNKGGSYTFKTLTGQELPYASKTIITHDCVSCQQVDNGENNNNYNNYGVSDVCGQIYEEAGKCEKQLYSAGVVAYPNQNACNYIKGIKVVRKDGIITQVGSKADKTASIFIGIFVVAFVLLAAYVYYLKTKLDRVSINLADKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAK5</accession>
    <name>A0AAD2GAK5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS22477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAK5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1966891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="386" mass="43225" checksum="5E253B598FA44CAC" modified="2024-05-29" version="1">MAPIYGQVVAGPPGSGKTTYCTGMEEYLRLLGREAFVINLDPANEMPSRLAGKKQKSDDGEKAEDDNDATALPYEPLLDVCESVVNVTSVMNQLGLGPNGGLVYCMEYLEVNVEQLVEMIREKVAVHNNPYLLFDLPGQVELYSHSKAVPRLLEKLVKALDLRLVAVQLIDSHYCTEPANFLSAALLGTTTMLRLELPTVSVLSKVDLLTNYGPLPFSFDYFTDCHELDRLLPFLQQGGDFQQKDDLAQGVDEYYYTDDPDYQAARRRTRTTPFFRKHEKLHKVLAEVVDEFGLLSFLPLDISDAGSVGRVLAKIDKCNGYMFVDQKNSKAEDMFKCAVQSDHASNYEAIADIEEKLSAARERQQSEKPQQQPSGMNTLFENEQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB62</accession>
    <name>A0AAD2GB62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="210"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="316" mass="35459" checksum="51B75B3FB502D3F5" modified="2024-05-29" version="1">MLFNQDAVRSLSPWWKSDGEESWAGMSINTINSNALDEDLQQNNGFGSRANLEAEDFTQSDVYLDCMKDVEKTDDELTPIPPAMPESQTWNIEAKQFLHSGQHVDPHQLHPLGPEIHEPPPNQQEPEAVDGNLKPPPNNPSDQEEVDPHSSINQLDQDLANRSAFAALTALAAVVRRQAPNPGRSNIKGKGNHHQAPHRVIYLYDLTPQDIILGRGGGSNPKKSEGNRRWLIVIVPVWALRYRTLPNKAKSPFSEEMIRWLRSENYRFVEPTKDSAGQKCWIEVRHEDARIYNKVMHACRDCISPSIAAIDSAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCV7</accession>
    <name>A0AAD2GCV7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002469">
        <property type="protein sequence ID" value="CAJ1970171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCV7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="564" mass="63288" checksum="84C5F36C9F51AE99" modified="2024-05-29" version="1">MRKEPSAASKRPGLPPTQQESGSQVAGPALKKQSVEVPQEEYDSLLLAEKEKKESEEKRKEEQLLFEKEKKELEKRLKESEEKRKESEEKNKALEALETGEYYMSYNDLWNINLVEYKQDHLDALTRAGPPSIERNGLKYYERTLRLATDETGDYVVAERDGRSGVSSRGSYTKAKIWPFDVLASTLSDDKKRSRHRVKGSQVAHLVPAGKVFASLHTYVAPMVFGLQNASFETVQKLIHGSRKKNEETDGDKATTKKEQKPDSNESASETNAQQLGKNRKVNLVGTKHFTTNMIRLKGQESNFDTKPHLLIVPILSSKNAVAWQGEGYEALFIIGTPKPLNKMGFNTVPFDGNRSEGLDHEGPRPTVVLDDRTVDESRTESIGAVADEVGLKEEGTTASEEEIEIARKLLETAVLALAHCVIRDAEKYNDWDIQERDALSKLKDSRVFPPDPKQVWVPSVIERSSAEDRLRVRKIAFGSYDAPVGESDVGHPAPDPMLLIAKAANNWAAAHRQRLLAGAEEEEDDDDMSEGFIIEMESHLGHLDGMKRKQIDRDVPGMIIEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGQ0</accession>
    <name>A0AAD2JGQ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="548" mass="59556" checksum="06B807791FD77795" modified="2024-05-29" version="1">MNSANGTLKNCGACTKDMERSAFSKKQWERKKFRRCKACVENENAFQRPSKKDYPREKKENVMAPPQAPKELIEEKPHVTPERPPLDPVVLADKKVKDDKSLLSNLEAMATVANSNEIIMNAIAATAVTPIQTDEAKQGTKDVLDSEILSETTKSNSISISEKVLSESSSVATSSEAITSGDENTVAQNSAPVAKADKNTEAPLSIPEDQQASHSADLSEDAKLSGRKSNGPLASDSQPLAADAPKTSFLEMEPITPSRVEEMVQEHDAIFRAVFEPTNDQEEHYDDPRLIQRVSTEDVMDYEVGPIVNVEQEIYDLLNNPSSEQGILFVDGSEIKMDDAEDSPSASYSGKRQSKESFIFSNVTMNNEGQTSDAHFEDTTPDHPSPESPPHTETGLTRESIERDAVDWDPSAMAQLSPTASMPSSFPPVPPIEAEDDEHEDEDNGGSYEKVLWQHSSSITYACGACLVGVIIIALLLPQDHTVLLISTGLSLFLLLGLAGIMRFSRSYDGDSSINDPDGLGDVLAVDSLREPLLSGADEDGEIISDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH39</accession>
    <name>A0AAD2JH39_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="566" mass="61518" checksum="1E26DC8403D9D5FF" modified="2024-05-29" version="1">MSDNGQRKAGGGSTGGSNHSNGRRPNGAAPKKKRTPAGKSPQRPPGKGKKGPQGALRGKSPTRPPGAAGKAAIPKGSGRGAPIPKGSGRPIPKGSGRGAPIAKGSNRGGRTREEAPPSSKSRTSSDDELSSDESSSSDEFDEEGLPPSSVASPSTSRGRSDHSRGGGNNSNRSNISGATIRDRARGATIRNNPAFRSEHSRGARSNHSSDEGGAIIPYEESDAFESFHGDIPDQDYAGDAYNGALVPMEQNNGEYYDDGYNRDKLRPPPKIKLAKEDSERGEFPNDKWYHKCLRHFRILSPHPQEDEVKKKLRYVIWTTLILDVLVAIVSIATFGDGVTSCCGTAVMAAGIPGVNWDLFMQVVTWIYLIGIFLEIHPVVREGPIPWNLLNPSFGFLISFAVFVDDSKGEAITIWIMEMASVILELVTFRMLKHLHNRKVQRLEELESDIANEKYSHGYRKTAFLRERRETRLVVSDSEKKLRYHFIGAAVNAALVSITLLLIIFVARGGGLCLVGGAGGGLDIFNSDQKSRCNKCGDVNDFSDRCIICNFEGTENVEPDQCYFPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH87</accession>
    <name>A0AAD2JH87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF15">
        <property type="entry name" value="FH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="601" mass="67679" checksum="2A8B335487B6BCBC" modified="2024-05-29" version="1">MVKHVMINEGSNQVKEYQFTELENQTKAYSKEELFRFKKQFQAESLMNQVRNMVTKIMIGKAGGQQNATRAVVEPQVDAIMSKSVDEILNFLAKNGVKLPPPPPPPPPRAGSNAPRAAPKAPPAVPASNGEEKIRQMVQQKLLKETDLRGAVLANKVDLIMSLPRPKILSILQREIPPPPPRPAGASMQKKKYNWIKECQDYWSYLPPPVVGALKVLGYNETLWNNNEQPALSDKAYTELTPEQQNAIRILGCSPQEWDNPTPPPPPPSAEDDKTPKKPVTPEERAMMLKIKEMVTFKLKTELNLTSQDPSEAILLNKAVMEILSLPKEGVQEYLRKPLLPPQIQAQFQPPPPEKLNWVWDSKAYWYALPPHIQDAAKVLGYDEVTWNHTEQPEESDMAWRHLSIRQQEAAITLGYTKDTWDEGNGDLYTGYSDAEDEKDEGSAVGENDSDDESDDFSESSEKESVAADDDESSVDEEEFISSFITQDEEDGAEDLVANFISADPSVVRELTKKDEVLDDDSDDGADIPYISNSILRRNSSDDDDDDDDFYANFRKEGKNRSSDVLTEDETESTEEKEKAPEEQKFSGQLETFMSLWSFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHN5</accession>
    <name>A0AAD2JHN5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHN5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38451">
        <property type="entry name" value="TRNA (ADENINE(22)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38451:SF1">
        <property type="entry name" value="TRNA (ADENINE(22)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12847">
        <property type="entry name" value="Methyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31904" checksum="6C0EBBE524840F4A" modified="2024-05-29" version="1">MRCDHHAPTLGHLVELAADHTNTDRDSEGTRASTARSIADVGTDHGLLAMSFALSGRYDRVLGVDVSEQALYNGALSLLETAQEIYEQQLDDDSNGDGTEGEETRIPITFRVSDGLDNIDPGEADTVCIAGMGVNTMIKILSMPSDTADITHLDRIQCQQLLLQPTNSRPSHLILLYDHLQKSGWRLVDERIEELSKRWYVSTCFQRKSKDEEDNVDPNINTHTPMELPTSKLIQLKDDNPMFSPFQKYVAHHCQWIEMDAGARGALKEADERWLKAFQQLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JID0</accession>
    <name>A0AAD2JID0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JID0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF18">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="3"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1953478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="377" mass="41387" checksum="D947719E9AE03141" modified="2024-05-29" version="1">MKLKIGTLGLPNVGKSTLFNAMAQQSIAQAANFPFCTIDPNVTPIAMPDLYLEELGKLGKSIKTVPATIEWVDVAGLAKGAHRGEGLGNRFLGTLRECRALCHLTRAFEDESVVHVDGKVDPVGDIEAIALELLLADQAHVERRLERGDKVPEEERTVLEQVASGLALGKPARSLQLTKEEQLHIRGMGLLTLKPVIHAFNVDECDYLLDREATLERIQSEIVSKLEFFDPTTDVWTIVSAKVESEMVSKSPEELAVYLESLGVEEDFDRKLLSYHQLPQLVAHVLGLKLIYTGPGVPPERSQTTKAHLLSGPLTAEGLAGRIHGEIESGFIKAEVISAANLLEHGTYNAAKDTGSIRMEGREYQLENNDVVCIKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIY1</accession>
    <name>A0AAD2JIY1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="197" mass="22883" checksum="7ABDD4216A835167" modified="2024-05-29" version="1">MNKQTTTVLINKNIRNDYEARFLLQSKSRSPSKSPHSPTALSRVVTLLGGEDALEFLTIYFTERIVDDDILSAIYCRDLNTKTLVQLQKELLLFALCDDLSELTSSSKKKVYNQKILQKHVRLGLMEKEEYFDRMASHLANALASCQIKDTRAIFKTQRRFAALRPLLEITHEHMELQSQQMETIRLPFFRKFAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKY5</accession>
    <name>A0AAD2JKY5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKY5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="252" mass="27855" checksum="1AAD91252A67B52B" modified="2024-05-29" version="1">MEEDKSKQAPKKTDIFVHGDVGSVEDLIKMLANFFAFVKYCVKDFTFDDPPLIVTILEDFMNSLHTPAAKDWIRYNAAVPHLPLCILLEMNQILQIVVGAAKNKSTQSKLCNGQPIMADTFVNAFNRVTQAISHINLSISMGNLGPYGTCPDLHAILNGKPTPAPKRESPNSRERPDPTKRAKHLPQGSHPGYLTYDGPGRLPIAPFKFKHPITGKQAAFCSHFSFAKLPLQPPSMPQYPLHQTVCGNHGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLR0</accession>
    <name>A0AAD2JLR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19014" checksum="B0DFCC47A1329819" modified="2024-05-29" version="1">MASAETELAATSAQKADSKIRTDLATLQEKMDLCTSMLHPGAAAPSFSTDNTTMMSVVGFLEACVPRMVELVEVAAMGAVSEEVLMECLQKNDALQKVLTDIDQAAMTETSASTTTASADVPSVSDQLDDLLLDDGGAAAAANFTIGDDDDDEGVDDQKPSANLKSDDEFDSFFAERTASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM20</accession>
    <name>A0AAD2JM20_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1961937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="214" mass="24954" checksum="EBD8324F4A7AB398" modified="2024-05-29" version="1">MGNNNSRTTNAIQSNRVVRPGLFHDLEKLAHATDFLMKRSCSSAMDTPMLANSNDFVLKRSCSSAMDAPMLDIAKRSCSSVTDAPPSKRLRRSKRRRKVHFNESVRVCFIQHHSSYSKEEHRAMWRSSFEIGLHAKRNSVERYYEGKNWRNAPEESDMLFDILLGIRYHPCWTTPRKPYHGGVMLYGHNYKLASHNHRFFHHVRTCGMLAFFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM29</accession>
    <name>A0AAD2JM29_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS20179</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="518"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="741"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1963472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1114" mass="125053" checksum="51CD813309DE4D27" modified="2024-05-29" version="1">MGSHDTDDLSVDSFQSHGERSKASTTIGSSSGGDAMEHVKLLRKDSWIQSLRFLSLCILLVVGYVVAMTVYVSLKASEYREFENQFEAQSEQIGEGLQAELQIKLQAMEALSVAVTAYAESQSGLTWPNVTLPQFSYRSESTLTIGGGIFVGLQPLVRREQQEAWEQYSVQNRGWKEESIAFQQKHKAQNDTLIDESLYPKNISERIFHVIDGVPTAIEEDLMLPVWQYSPIHPGSPYVNYDQYGKERNRGALNEVVEKRAAVLGMFFELSQSSNGHDVTTDSGEEHIEGVTESSPAVDIWYPVFSDTTDDRSEVAVLSMTTRWDSFLLPRLPANPIGLIVVLSNECGQVCTFDITGDEVTYLGNLDSHEEEYEYYEKDFYFMDMEEESKVSDVSLSPFCKYKLTVYPSTKMRDTYATNDPNNFTIAVASIFIFTIMVFVAYDNLIERRQTFLATAAQKSNAIVSALFPKIVQDRLFQIDGGAGSGKAAANNAMKTSNDSAAGNSSAPPIADLFPNTTVMFGDIAGFTAWSSSRQPSQVFILLETLYGSFDKIARELNVFKVETIGDCYVAVTGLPNPQEDHHLRMVKFARRALEKMMVLTRELEVTLGPDTTNLGFRIGLNSGPVTAGVLRGERSRFQLFGDTVNTAARLESTGKTNQIQVSQATANLINASGKSHWIRKREEMVEARGKGQMQTYWVKHKASSAERSDSFTGSRSVDSSERIQVGSKTAGVRKTLIEWQIELLSRLLKQIIYHRKTKSGSKSENFASNVYGKGLPRDEIAEKISMPAFAPNSSKRDIDIDSIELSAEVVLQLEDLATSIAQLYHDNSFHNYEHACHVTMSANKLLQRIVVPKFQASTEFSKRAHDYTYGLTSDPLTQFAIIFSAIVHDIDHHGVSNQQLAKERNRLAVMYDDKSVAEQNSIDLAFEMLASPCYSDLVSCICADEMEYKRLRQLIVNCVMATDIFDKELKEFRNNRWAKAFDDNTESASDLKATIVIEHIIQAADVAHTMQHWHVYQKWNERLFAEMCKSHEAGRGPEKDPASGWYEGELWFFDNYVIPLARKLDECGVFGVSSDECLNYALENRREWESKGRSIVLEMSSRYSMTISEGDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN16</accession>
    <name>A0AAD2JN16_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1963978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="57397" checksum="2B89C5E385BDB2ED" modified="2024-05-29" version="1">MPPTPNMGNADEMSQLLGEKQPQSNNLNRNKSWFQDISIWNALSIALFVASLAMLLATHHEQNQENGPRIPTFSTNSKYRQVQGLGFQIYTGGAPALLGQNGTQHLNPECVGLKSYGSMWTEEGYEMQCYIGDPDNEKDAQNRLKIMKDAVEKAYNSADHDPNTLKIFIAPEFFWRGIDGAYVFMDEAPGEWDVCGPVCQILKGLEEIVADKRFENWVFMFGSIIASETVADGGEFPTMFYNFAPLYLGYDPEKTDYHGKRFVVPKRYVSSSDFLTPVRNLNSSIYAEIGQHQLPQQETTVFIGLMKKYDNHMWLDFKGELGYIGYKMIEYGWMMLDGLSLSVEMCLDHQMRISLNAYLADITTGQTTEIPSTSSTGSGVEYVPIPTYQAQIGLVSSAGMTVTTDSLALTDHGVIFLQDGLSNATNRMFWSVEGCELGLQFEGGTEAVQRHASISSTDIRFEHNPVLGFQRRNVYHPSKWEESVKRSFSTQKYQPQLTIFDPVDIAKVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNT8</accession>
    <name>A0AAD2JNT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="47668" checksum="447398841AD16EB2" modified="2024-05-29" version="1">MRSCSHGSSIQSLTLGSFIFLGFLLFLLDWYDQKRAVKQLKSEQSTFKNQTIHLEEDARDRSVRDGPPVTSDSDSNMLPRSSMDTEERYADGNHITESLTANISWIPVDEDERQQYMGNGTCFGPLKHCCIGQCRQPSNVIPSTDSRLFRKPNVKLSNLSDLLHLVETKVKKPPESACRLIFLGDSLIGDHTAAAICQLYRLGYQAVKCINKEQFGSDKRYGENTFCRKRRQGPGPFSLFLQRQDEICPDVTLQVMRTQDYNHEISLEPESSGIMVWSDGVHRNKPGEIREFMKENFVDMVRSMQVHFPNWQVLFLEHEPQHFKTSDGNWQKKVTMCHSLTVTNTSNWRNQEAAQTIEEENLPVRIVPLYAQMLPLWDLHIGKGDCTHYCYMPWRFDVTWHGIIEAVEANLRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU77</accession>
    <name>A0AAD2PU77_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="471" mass="52638" checksum="73A4438162104ABB" modified="2024-05-29" version="1">MQSSLPVTTKGEKKKVNFRNSISRGSKEFNIKQGSKELTVNTPNVHSLVRQREHEIVRKGFTTIELPQNVDKLEELNSDLLSVKRLVDKQIAKQANLLHGLSIRIYHNTQLAHVKLRSEEFTFLSCMTMRKVKAAQHEYMEALLILKGLEAFRTHLSYGLVNAKTATRDLAAIQGAHGSPKAGTVRKPKGRRSSYSDESLMKQLKKKEFFPILETQPDGTALFIYSDTAPFCNHAVALHRTKEIATEGYSMVKLPSGYSKLNNPCAETKHAFGLVQQARQDQVLALKRHVVKLQVAVDIAERYFIAGHERLSAKGMKKVKFIQQEYLHILRLIEAFKAFEGHLQYGFMNLDTIEDDIEEIKSVPSSKTPCTECDEDLVTQLMDQKFFPMLFPLLGGGVKIHYSHNPPKDRSSPSSPNSNSQDSRPSIPNARRLSVGNMAGAGKAPGKAGRRPSLSGIVNRPASARRLRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV38</accession>
    <name>A0AAD2PV38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS14453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042862">
        <property type="entry name" value="RNF32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14991">
        <property type="entry name" value="RING FINGER PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14991:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="629"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="665"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="756"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="692"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1953856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="818" mass="92623" checksum="D645AC82F6947627" modified="2024-05-29" version="1">MSTTDESSTSMDDEHLIVEATYHEQHANSSAAFVLLRRRRRQQLGWRHHISGSGSPTRFRRIFIRPLMVFLIGFCYLQRRSIVVRKNPSQQQQQQQQPELEEESSRWLKPSYSTSSSSNLEFHFGNETHEMDFASSSSHTIRSNNNNNNNPNLVSSASRMNQHAFHPPYFPRHVSSSSLHSSSADSAESDPETFGWEPSLYPNPRENPQKCGIAYLFQNEHFVQQSNDTTTTTSSTTTDNSLQLCDPDWVLGGIYLEEIAIAMKNFVATYSSQPPFEVSPPARKTRMLQQDKRGWEIVDEDYLKDTPPYLQQGTPPPIDPVNNESAGDENLASPDLLDSEKEDDSIGEASVPFVELAIATVRKMHISAVLEHGIYYSYEDEEDMVSDAAQIFARYLHDRWWQGNPNGAYGILIFLSIQDRVCFISTGSAITTVLPWWRLEHIVASMKPDLRHRDYGHALLTAIHDLSDMLAEGPPTLADRFHDFMARFGVVIAFAAFTFFFGAWGEFRDRRKRWEYADSRSKMSQVEREKARLLQREFKTRSCPICLENFNDGTDSQGNLYELSMEYEKEQEEYADSQDRSTGSRCCCTPKSDKKVSSEEKEAPNNSLLRRVDSYGIPLLGPDHRNVKMLRCGHIFCDSCWKEWVHSGQGNPCICPVCRQDVGKASKHRRRRRQQQLQAEEARREEQRLEEAANAASTAPPNTDTTPLMNNTSARSSGGTYDSLSSYRASSIIDGVDEENGHGGEGMFSELQYTLSEGGGRASLPSNSSHSMQPNPFQANARATNGGQEGEDGEGDQGETQSLLRNGPRRAQRNWFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVP4</accession>
    <name>A0AAD2PVP4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVP4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="327" mass="38071" checksum="7C1C5A89CD55C7A7" modified="2024-05-29" version="1">MQFRKKNIPETKGRSNVLNKVFLVLICAAIGFFTLYDSPTMSLDAIGATTAADGSSSSDSADASSDGRTKAQQKIRQISIIGERNSGTRWTFGHLGRCFNHSIKVTTTFTRYKHWFQFPDYKRYKHNTIVVAQYRNPYTWLKAMQKVPHHSPAHLAYRADADWEAFLSKEWTMERIGNDRWPNQTEPCQQFFEWKDIISCQRYPIPKDEIKEHKFSDHQPFYEMRNDGSGEPYNNIMEMRTDKIRNFQTVKDYEGVTAMLTMQYEYLLSTGTQEMLDQISELTGIEPSCKAYPAQNRSARALSPDMKEYIDKHLNWTVEGWIGYKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWC6</accession>
    <name>A0AAD2PWC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="3">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS18449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002038">
        <property type="protein sequence ID" value="CAJ1960033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1960033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="826" mass="92777" checksum="1F25E03D75415A73" modified="2024-05-29" version="1">MMEKNGSFFGQWVEEKKIARLYIDEVHTPFLEMDFCFKYDCLRKHVPSLTKKGVQIITMIGSLPNGIQEAIGKWLRLDGGLATRLATLGLDNMPMEVVTLMDRSRWLKFLGGRLEKGHVHIFCPTIDECNQMQHALFYNAGALTISHAVVNSTMAEDDRRLVSRKWHSGMISVLISTTCALVGNENSKCKTVVVYKHVYNLVSLVQAAGRLRPGQRDDCLFRCVVSNETVIPRTDGLKKHLKELGIDHPDVAAFVDGGSLKAFFGTSQCRIGFLNREINGVAVGDCGCCDNCRQKLAAKSIHLGKPSLNAAGTSVLGMNDEEEREIEMEFSILCNKMEAACLVCVKSDCNGEKCMTGHCFVCGRRGHSVKICPLKSIKPRDAVKATACQMCFMYGPVHPNFSCPHKRMKRFIFHKCDPSKIGQLYGQRHVDWKKGILLLSGWVSKTSKGNLKKKRLAEQIQNPARQKKRERSSESVGDISTIGDISTICMRRTGGSGGRSKRMSCMQKRKIYKVGGLELDILHQKAPLLPPDYFHNIYVRHFGSQVIEDEKSALKIYRTMRQWYRNKCLFVEGSLYTTNGWWGRPYLFRPREGQMLDLGLKVYNSKDKAYANTSIRVWALPRDCKLREKSLIFGRSTAAFSTAAVRTNRHGEFGDMWAVGLKTSAGVEYQSTNDGRIKKAACEWKRALDEYATDLDDNGCMQEVLDGIRQSQRKLAKTADLPTVAVSRNLCNSAHYDLDLSKSLAVFLQELVSDGRTSGKHFLVFPNVSIEGQSGLVIDLRGGALVEWDGRFNFHCSYCGHDRKNVTDNYGIMVGNMWGSLLPKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWH0</accession>
    <name>A0AAD2PWH0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS18851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042048866" description="Palmitoyltransferase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1960702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33579" checksum="3B92955C3D205BBB" modified="2024-05-29" version="1">MKIPINTLPLCLFILKGPLATCAFSVNPSSLQESPPIHHPRTTRRRRTNKKKDHDSVVISPLFYRLRDQYDTNTGIGPLHGLAGPGKLAGTQALIQALLQEHHDESSSSLLELLDNTRDPKMGTTPFHWAVCGMTTSLQGGGGSIQVCQWMIDRVFEEGGKDSVVKLCNLPCRTHHSTPLMYAAWGGNVRLCELLLDEGEADPMYADKRGQNALHWAAAAGHLKVCQYLAGKRYHQYFSSASALLLEEAEDDGAVQEQEGADSSSAKHMEHGPILETDNSGLTSLDYAIQYNRDDIIEWMMKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWM7</accession>
    <name>A0AAD2PWM7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWM7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="10623" checksum="FCAF9DB154AEC0AE" modified="2024-05-29" version="1">MFALSSRVIPSTVARASRRTYSNEVANTIRNEKVWFGDISTYPIMAICGGACIGAGAYIAYKFQSSPDVRWSKEKRGSEIRWWGDDKQSLRLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXL0</accession>
    <name>A0AAD2PXL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS22287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXL0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042286900" description="40S ribosomal protein S19" evidence="4">
        <location>
            <begin position="21"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1966704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="67603" checksum="C4BF174986A6A867" modified="2024-05-29" version="1">MSPFCWGISLLLMMMQTVTSAKVPLDLSTPPRSNPPKLKFPWCKTASIDEYGKVVTESVTNTQQLGDQAFDQSQSSQWMEYIERKEDRLGDAGGAGAYDTMRCDIVFPITSDEEGENVVIWGEEFHLRRLKRSYKAIQQQEVTDQELEDAIRDSKKIIDILLSLAKSDAKTIPGLKEMESETFIVPVRLTILWSSPLKQLKSVRSTPPRIRGHACSSFELQYPTKIPSQMTASLAVQLREDESGRREFIIDETMPTRHADPQKKIASWCRQRKKLQGSEEIEEVLMVRERNDDEGTKRLEILEGLSSNFFVILKNGTVRTATEGCLHGYVRHLVLSLLDQYGLKFDPRPIFVDESSEWEEAFITSSSRLIYPIDQVIIVPPSQNDNQSSKGFWKYEKSLDSNKEMKCLLLRKQMLRSNLPADYHPGDCQRQRCNINQIASNIKMAEEARGICVRDVKADAFIAEYAEHLKNSDKFELPVWSDTVKTGVFKELAPYGDDWYYIRAASIARKVYLRPGVGVGMLQKWYGGNYRRGARTEHFRKASSGVIRSVLIQLEAMKVIENMPNGGRRITTVGQQDLDRIAGAVFAQGEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY94</accession>
    <name>A0AAD2PY94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS23770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000052">
        <property type="entry name" value="Aryl-hydrocarbon-interacting protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000022">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF552">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE CYP26-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="318"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1969554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="489" mass="53649" checksum="43A0D1B62B8152C7" modified="2024-05-29" version="1">MAEEEEVWIDVSVAQDGGVLKKILKEAPEGASGPPPSGNEVEAHYTGTLSSDGSKFDSSRDRGKPFNFTIGQGQVIKAWDEGFASMKIGEHAILKCRSDYAYGDSGSPPKIPAKAELLFDVELLGFKEKPKERWQMSTEERLEYATKIKAEGTELFKKKNYAEATAKYEDAAAFSVDEGISGDDIPEAERPLYISCWGNAAMCYINMKSWADAIHACNKVLEMESEANTNIKALYRRGLARIRLGQYKEAKVDLMAAYNLDNSNKDVRKALKQLKDEVAAAKKKEKDTFGGFLGKVDIYNDKKGPLVPNAKGDNPHVFFQIKQGDEDLGKVVMQLYKDITPKTAENFRCLCTGEKGNGSSGKPLHFKGSTFHRVIKDFMIQGGDFTNGNGTGGESIYGEKFADENFVIKHTKAGQLSMANAGPGTNGSQFFVTCKDTPHLDNKHVVFGHVVEGMDVVRKVENTSVGGQDKPEVDVVIADCGEMPADYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBV6</accession>
    <name>A0AAD2CBV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Polynucleotide phosphorylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS694</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1914677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000958">
        <property type="term" value="P:mitochondrial mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02393">
        <property type="entry name" value="KH-I_PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000001">
        <property type="entry name" value="Polyribonucleotide nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252:SF0">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="831"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1914677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="916" mass="100024" checksum="7782F966559850F6" modified="2024-05-29" version="1">MIRNGLRISRGLRRPRPTQSTIFGPRCHVALATSRPESPRWFAANSSDTEAKEDGIDYSKMNFGSVIDGPQIRFGSGKIANLTESSIVGASGETVVMATVASSPTEDQSKSSSSAFSQYLRQQSSFVPLTVDYRQRHHAVGKIPTSGNRSDNRRPSDEETLAGRAIDRSIRPLIKKSDESIHLSCSIQACPLNDQGGHPIALALNSASVALKNRLQEPIACVYLNVMRDGTVLVDQSTPNKDSICELLYAGTRDKVVMMEFSGMLPETNLINLIELAHGCVQPLLDTQKMLVDTRKKQEEIEDDTLRKELGLPPADGTKISIERESTAVSDSEELFEEIFDFCKKRIGESSLRLFGVSDLSKVGSEVALAPQVHGSSDPPLVSKKLRGRKEQMLRDEIQQKLVDFEPSKQQLDSYKEMMDDGNAMPTLADLVHSKLLKESMAKAAIKHGRRADGRGDYSNACTTIRPLSMEVPALPACVHGSSLFTRGETQVLCTVTLGPPKDGIPIKDPYKPIVESSKKVDEKLPHQDLPVGSLRYLNTQEYLESDLNTRRVMADREQTGDSGTMKERRRAFLQYDFPAFSKGEVQKGPSGGNRREIGHGALAEKALLPILPDAEAFPYAIRMTSEVTSSNGSSSMATICGVTLALLDAGVPIASPVAAISVGLADGKTEKDPHRLLLDITGNEDYFGSMDFKIAGTDSAVTAFQLDVKSPLPLHVISEALLLAKDGRIEMLSEMELQSRKTSGGDVSNLLPRSDLKDAAPRVNIVKYDPTRKKSLVGPGGAVIRQMEDRFNVSLDLTQEGRCLLFGDDREMVRQAKAAVMDLVADVEVGGVYEGTVIDLRDFGAIIEVLRNKEGLCHISELVEKDDIKRNKSGTLGLVHSVLKVGQKIDVVCDAVDPVQGTIRLKPYKKLSATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBX0</accession>
    <name>A0AAD2CBX0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000014">
        <property type="protein sequence ID" value="CAJ1927216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1927216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="813" mass="88394" checksum="26AA667227B2A128" modified="2024-05-29" version="1">MAMATVSATPNPTTSNPNTTTIATSLEEHEHEFQYLNKEQEAYSGNKVSEDDQDNVQDNDDDDDVSPDDILAQLNAAEQSSIHMMNNKTNNNEASVMTPATSTTTPTKDNKTALLSSLLLEPPAAPMKQQREELFQYYDADEESVEISHLIPKEEAPPSPIPYIPEEEEEEDYVVVMQEPAQVEEGPIDEPFDCMPVDDSEAGILKKLEKVVQDSDRVLHPNQPLKVAAAAAAENHEMAIGMTPLRSGDPMRSPGTMSDCGNSTVTGGTGFTRASVKIMGTNKRPQQAVMKLRVNDYQYEPLEKVTNQVEDLPFDETTSHNFKTALRNMITTTAATIQKAAAKHNNTPDTTMMDDADTDDDDTTTLGGEDDDDDEWTADDTSKYTDTDGDDTTTLGDSTVDTDTPMDEAPGNFKKKSAKARRRQRLLEKSRQMESKSKADLGWDETLLDAVFSPDVIETGLEMADFLQSGAEATAKMTKSMLQDAVRKLEQEEKALNGEVLQDDDDDDDGDDDDEEEETDAGERAYRSVAAAATGSNLQGNDNYDDYGDEHDTMGEEYTLEDGDTTTLQDGDTTTLHDGDTTTLHDTENGDASAAASAAATSVKDPWDNHNNNSNNSNKKKKKKEPKFADLLQKGIPLVNRKLERIVNDWRASSSSSTDNQSTKTDDAIAQEKNTPTLAPAEDRVSAAAAAAETTTTDDVALAEPKEEEEGAATTPPPTTTTSAVEEPSVDNNKAMATDAASTPDKSAQAVAEAVAESEEATEQEQKEAEETSSAMAQMEMEDPQALEDEEEEEASAGESLLSMDKPTKRLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCK3</accession>
    <name>A0AAD2CCK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000036">
        <property type="protein sequence ID" value="CAJ1928301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="337" mass="38930" checksum="ADA8DBEAEAD6CBDA" modified="2024-05-29" version="1">MYHLSPLSTSIQNRYHNTLRLYPWRDGYEFTRKLLQQESYHDSGGDHHSTIQAILVSFSEHGFQEYLQDADAITLFEEIGSNSQVESVTIELDVFSELPTSVAIPPILAVTSLLTAHNNRIRHLCLRKLQLSSHKEDDDLDVNGMVEALRIHPTLQSIEVKHCTFSKQCHLQRLRSTLTGRKGIKHCDLFDNRVSFTKKEEGEGKIDYKQEYEPCSCSQSWRSSCVPFKNHQFLWARMLCLFCFSSVSVLLMARLFLSQEEPILWNHLMPFASSTTPLSSSSSNRKLLQPEQEMPDINSYPLLSIMPWQILPKDKKSKRRKTKLQKSSNTCKPYEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDE5</accession>
    <name>A0AAD2CDE5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDE5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35399:SF2">
        <property type="entry name" value="DUF839 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35399">
        <property type="entry name" value="SLR8030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041961583" evidence="2">
        <location>
            <begin position="22"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="873" mass="94261" checksum="57514103AFDD3FA8" modified="2024-05-29" version="1">MRIFYITLPLAVSCLAGNVNGAHINLVSHSNNPGTLGLCQGDCDIDEHCADGLICFQRDEFEEVQGCSGGEYDGSKTDYCAPETFPTSPTSVPMRQLPVPTVRTPTNAAPVAIAFNPTSFPALVVYGGNPPASLLPLGRCEGDCDVDDHCGPGLFCFQRGRNEPVPGCSGGAADNSRTDYCVPKAGFPRIPTPQELPSMPPTPSPSTATTAPSIAPEPTDEPTDEPTISTIPGPQALPSISPTPFPSTATASPSTAPEPTDEPTLSPTISAPTYSAPVSDLNPLPALISFGSDPPPFRMPLQLCQGDCDGDSDCQPGLICLQRGSNEPVNGCSGGIIDNSRTDYCVSGPNIATPSPSLSPVEAPTNTPSLSPVEDPTNPPSLSPVEDPTNLPSLSPAEDPTNPPSLSLVEDPTNPPILSPVGEPTFPPLPDLVSYGGDPPPAVYPLKLCEGDCDEDSDCQPGLICYQKDSFEVVPGCNGGLNDESEEDYCVQPVTPAVETYTPGKLTVQKLGLLLSEGLDARIIATTGERVRYHDGRESMETFHLNPDAGATFQDEREGNEGGWIYVSNSEVNDAQGGVGAITFDKDGNILEYKMLLKRSSMNCGGGRTPFDTWVTCEEVDAEGQLYQVDPTGKRSPQVLTLGKDGGRFESFAFDVRNRMIPHFFVTEDHEQGCLRRFTPLNPDWENDPWSMLHGDGKVDYLFLRPSETGEFGTYEWIDDLSRARSNAQKYYRFSEGIDVSGSELFYVCKESKHMFTLDLDRGTYTRQSTVNGLFDGTPDQIERVLEGSSEFLYFTEEGGRDAGVHARNADGSFFTVFESPVYPDETTGLSWSPDGRIMYVAYQFTGLLFSIWRQDGEPFHQTQLDVKFHHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDS8</accession>
    <name>A0AAD2CDS8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS1213</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907:SF1">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="50"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1926407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="540" mass="59768" checksum="E6CD2F71ADAF7560" modified="2024-05-29" version="1">MTNSLFSWSLIPILMRAIISTIILRFCFLKNDASTVHGASVTRKNVDFHVAPMQCYTNLAFRRLCSNLSPTSTYWTEMEKADDLMPNIRESLIQRLLGDDPRRSDTSYYHHHQEQERRLVLQLGSNDPRKVQECVKAAMALEYKQLKEINLNCGCPAIDSGGAPTYGASLMKDPTLTASLVESCVQSCWKEGRNKVDVSVKCRIGVVDHADDLLDTTNTKSTPASPSSSTLGYDYGRLHDYVSHIENAGANHVILHARPAVLAGLSPVKNRIVPTLQYEMVRQIAKDFPNLKVTLNGGIRSLSQLKYEITASDGDEDGAVQSGTISSFMAGRWILQRPLDLIGIEGWLQQQQRRPRPEATNNGPPSSLSPTPPLELDAANPDAFVIAKHALEDYLDYCLQQQSASSTSSSTSTSTKTKNASSITTTITTTTTTTTASDLCLPLFLVVEQLREDYDDDNNDGMEVPPPMMLSYEEMESLYDLLQDGISELSDCMGKGNHQKKKSGHKDSSSVNFKRLSTSFKSLVGTKVANKWKRNRAELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CES0</accession>
    <name>A0AAD2CES0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000091">
        <property type="protein sequence ID" value="CAJ1929696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CES0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="14371" checksum="3602BE9AF5DAE129" modified="2024-05-29" version="1">MDPKVNGKFAKWLNMRYGSIKACTIVRGKIHRYLGMTLDFLVKGKLKIRMDDYVKNMLEDFPIKFNKDSKQETPAGNNLLEAGKGKLLSAEYRQIFHTTVARGLYVSKRARLDIHPMITILALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CET7</accession>
    <name>A0AAD2CET7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CET7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="649" mass="70691" checksum="13E744706DCD8946" modified="2024-05-29" version="1">MATLTTSSLPTRRPSPEHDTLEEAPEALLAPSRRRQQQQQYRHSSSIVLPSYLNQNNRGSSQGSSNSTVSSASSDLQLMLMMDPYGLMTLPQPTKLLSSNSTAQTHGMETEEEDDEASEFPSIMGNTSNSTTGTMEEEEFFFDPYTTNTLASSSGDADDGHDIMEAKDLLYYSMNSAQTTLALTNPSSMDATSSCCNNSCSASTTTTTRKEQAAQDASFYLQEEFFDSSSELSSEGEAELAAPVLFAKEDETAVRMDVAAKDIPFYLQETASEASSDDLLPAPVLLFAKEDETAVRMDVAAKDISFYLQETASDASSSAAEDLPEPALFAKEDETAARMETAAKDVTFYLQEEFHDAQEEDIIIMSPLEEEEQQFQDCQDDDSVDHESSTSSITTRPSSPSLQEDSKEGSFTDVSFYLQQVQEDDDTKNIVDLEGEACPSAVPDKIASFSKRIDMDGAIRHKTVFHKEHDEMVEELHSLDSGSESSRTEQDEQDNGIATAAATAAPVHAPETAPVSIINKSSSSSSATATTRTVTSVALFSETRKQNSSQRVDMAGVLQPTQIYGPILSKAASSSSSNNKDTTTITSSRTSSEQEKQEETAAFEPETLASTLKKEYDEHSTARNTHSTTTEQVGCGCGWSLFSIFRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFY8</accession>
    <name>A0AAD2CFY8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000023">
        <property type="protein sequence ID" value="CAJ1927628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFY8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1927628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="216" mass="24516" checksum="DA6BD02395D91858" modified="2024-05-29" version="1">MISRPKVVVLPVTDQVIQRVEAWAAAKGVTSMKFFDKKRDLETFQDGDQIAGVDDTEQGYLEEAFDQNYEPEDEDERDFNLRGQFDDIDDSERNEPLADADNDVDDVPELIVRFQGDDDYESDDDDSGDEGDEEEEPIVADLDHLQENVDRGTNDIGSLVTDLEDLQEPLEEEIVFEPEEPQVAKVTLSGQTYAQTTMSGLNLSQVTMEKMLWIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH11</accession>
    <name>A0AAD2CH11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH11"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="174" mass="20195" checksum="7B97BD84A97BF881" modified="2024-05-29" version="1">MSSSTPSNSYSITSSTKDGSTRDEMERMVAEIRLAAKQTASEPVKPKDLTENEAQQMVTDIKAAPESEDSETSKELTEQEVHRMIVEMRQAAEKADSEEAAEREMQRMVDEMKWATEEQVDEEAEERAYLERKRRQRRRKIERSRRTSKSPSRSRSRSKSHSGRKSRSRSHSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIA1</accession>
    <name>A0AAD2CIA1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIA1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="214" mass="24299" checksum="8F5BF53F5878AC97" modified="2024-05-29" version="1">MAELMFGMGMTKKKKADNAYVKETRDALKNVNISDTVEGSVRKEQNNRVRAEKETQRNTVRDNQNVNVSETVESNELKALAARGKAEKETQRNTIRDNQNVNVTETVESNELKALAARGKAEKETQRNTVRENQNVNVTETVESNELNALAARGRAEKQAERDTKATLKNVNISESVEGQVRKEQNKMEKDWKEAGRQQKKDNNNFDMARALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK54</accession>
    <name>A0AAD2CK54_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PROP1-like PPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK54"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PROP1-like PPR" evidence="3">
        <location>
            <begin position="112"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1936672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="723" mass="81141" checksum="5C16AA45C862CF67" modified="2024-05-29" version="1">MTEVDTDFGYSKGKENSDDDSPPAQSQEQEGSRTLSYNKIEERDKRKMEWVLSNTGDLLGEESEELGKMSERSVLLTLDLMRVWSKRAIKRESKAAHVVERLLQKLLKEKDAGNERLKINTAVYNIVLESWANSREEGSAERSEEILMEMERMYNQGNRDVLPNEASYNAVIKAYVKNGGRAIAPPKVTALVNRMERSNIVSPTRRSYNLLLYCLAKSNLEDAAPRAEDILHRMLQQYLETDNMTTKPDINSYNQLLGAWARGRNEGYEERMQTIYEEILDLPPDMHITPTVDTFNTAMSGWLKSEQPSALSKIEQILETMETSFKEGNRNARPDRVTINTICAAFAKTQGTGAMGNAMKLRASLEKEYDITPDVVSYNIIVDSWCKSGRKDSPEQAIEILNAMENDFKDGKISHAPDGYTYSSVIGCFANFRRPDAAEKAEELLKRMKDLWHNFGGEPLSASVYNAVINAWASSPSLESSERVKELLNEMDENHATDPSLPAPNRITYNTVIKAMRDGSGDDAAFAEKILYLLESKGAVQSAFLPDSYSYTSVVSAYGRSDAKNKAEKALEIIERMLLATENGNIAANPTVHSFNAALNACAFVKGDEKAKEVAFDIAMKIFELLQVHDAPDHTSYGTVLRACSVLLPSQKERREALVDEFFKEACLKGCVGRLVLTQMQFASSPEQYARLLGHDQIDKITVRDVPRSWTQNVREKVRGSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLI6</accession>
    <name>A0AAD2CLI6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000328">
        <property type="protein sequence ID" value="CAJ1934071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="352" mass="39532" checksum="9E429E4F4C4945B6" modified="2024-05-29" version="1">MRAKHAKRVDRALRLWLHPSTPKKDFPWCAVTHYISDWKAAQNGIISVKAVGPVKDENLTMISKHNDFVELTQTKYCPVEIPGMLKQATTKDFGPRTCLSMFLLVKARPLHADKVAAADVDTDSDSDGSLLDDISHKFTKVSTKGKTKIKKKVPKTSKNLSLENEGPVLTPAQQRRARESERKRKMDLENNVPSPLFIMVLPGEMEGTYLFISRLKVLGKWFPKSLIHTTRRKELVWCLETLRARPADQTQQGVDEAIDFLDGFGSDPLDVGEAKLEFDMDMADAKDIDDGATVAGAMDELLEKDSQLEAAITEIEFKDNLLSEQNSVLEAERLRSEKLALELAAMRLLQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CML9</accession>
    <name>A0AAD2CML9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000846">
        <property type="protein sequence ID" value="CAJ1939775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CML9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="605" mass="68901" checksum="6630DC3EFD6606C7" modified="2024-05-29" version="1">MTETFFRTDLNAESNIEDVYIAVSDIVERDCSDLEIDKVTLDSAQKPILFCRENQNQAEPPNGTTNVTHISNEKTWKTAFDTRAFHDLNCETELPAGMAEGDEDEDNLDTFSYPVFMDLVVRCAEKVQDDRSHASSDSIGQYDLRRCKLNIHLLGPTFKTVDYRTKQVDYTVMDGKTSDNCTLDCSTEINDEPRQIPPIGFIRRQVQLKALDCQSYKGPSCNGVAQTAGLYLQDRRNGKKMSLVLQTSTFWEYVESKRSKAKQMDIDIWVSLGARKSNDIEFYGEDESVVTQEDLLESQDPFTKYATPEKAKDLRARTGAERRGGQVVVARDLQQYFDRLYSSPQSKMYHAFTKEHMTYLLGYYQRKQANDILWIDERFPCEDDNESSWPSLEELPPEINPSSCDENYFYGKIPIRGEYAPLDSRIPTRPPSFEKKKKNKYEDMSAAMTPMLETLCSPAPSSVIGTTTNNAQDINSCWIAFVNETTETGPCYVKLDLDDTTMGEVCARENVIDTLKPVFCVDEDLNEAITKGDKEWKVNLALTAQDSLKASMHLKHFQKETVVGVVQSVYGRIRDDSPTVYVRLLVTDVFKLGEKQVRVNPFQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CND5</accession>
    <name>A0AAD2CND5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000657">
        <property type="protein sequence ID" value="CAJ1937492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CND5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36009">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36009:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042179433" evidence="2">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="316" mass="32912" checksum="44C5CE3E08BB96B9" modified="2024-05-29" version="1">MKISAFFLIVLSAVADVASAFTQLSRAPVAVRPNTHHKKNAVNKISVTLASPSSASSMSSMPSMSSTSLRAKNQIVDEESTGLFSDIQINAPYAVAYFGFLAIGYVMTTMEAPGASQAVLEKFLADPVNPGVNELFATIFNLLGLAALPFACLTMPGAKGQKPPLVPFLLGGVFAGYGSVGIALSTRKEVTAVKEEDLGWVTKNVLENKIFNWAMVALAASVFVSTGFLSGLAADAGGQIQGYSELFQSTAIASVSSCDLAILTVAAASLIPEDLKRRGFDSSGNKASAIAASTVVLPIFGAILYCALRPKLVSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNE6</accession>
    <name>A0AAD2CNE6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS2087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNE6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1930787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="525" mass="57752" checksum="45E1005BE610611A" modified="2024-05-29" version="1">MSAIDVDKIQTPMRETHASGLNLSYEWRVKQLKSLRRLIAENKVLLCQALKSDLGRHHGETLAGELKPIENEIKFVLKNLKKWMKAEAVPSSATMFPGFSYVHRKPLAAPGVLIIGPFNYPFFLTLKPLIGAFAGGNPAVIKPSELCMESGKIILELFSKYFQPGAAQVVLGSIPETNALLEKSWGKVFFTGSQRVGKIVASACAMTLTPIILELGGKCPVVVDENIRAKNLQNVADRIIFTKTYNAGQTCVAPDTLFVHDSHVKELCTCLINAIETQFGKDPKQGELGRIVNAASAKRLQEMILEAEGDVTSSVVCGSSAECDTAIRYICPTLILNPKPGAKVLKEEIFGPILPIVTFSSRSEVFKMINGLGSHPLQFTVFTSQHKVFEEYTKKCPSSAAFRNDCLVQLSNHNLPFGGLGGSGIGHYSGKYSFDAFTHPFPSTYRPLGKFWDLNNLRCHPYGDWKGKFLDNHIIGLPDIPVLHMKRLVLSTALAAALASTLATVDEFRFAVAQCFRWIADQLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPG6</accession>
    <name>A0AAD2CPG6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS7489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1941373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="288" mass="32410" checksum="7745EA7A96A75033" modified="2024-05-29" version="1">MRIPNEISAQGASSCQKPQFPLKLHAILEETEAFDHHAIISWLPNGLGFKVHDKDAFEEQVMPKYFRTNKFKAFQRNLNLWGFQTLTRDPDRGAAFHPHFIRGKPDECSQMERVRVKKEMKHKKVILTPTGELEPLWSSSSQSSSHASFLPAFPTRSQRVNTAKVISVTSTPPLEPGVSPKCIPPSLSLPRKVSLHNRNAVSNKSSFPLNLQNYSDTPVSPERSVRLDLSFQQRYRGCLPDCNAVSKNSVSLNVQALQDYFALECLRVVSTRATLFWAGNSGSSLIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPW1</accession>
    <name>A0AAD2CPW1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000735">
        <property type="protein sequence ID" value="CAJ1938586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPW1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="427" mass="49764" checksum="4CB2BA039E87B526" modified="2024-05-29" version="1">MVVSDTKLLYRYNHADFTIKTIYCDGEFRPVFDDVKDEMNVDMNYPSRGEHNPTAKRNKQHIKALFRVQYHHMPYKALPRIITEAIAKQMAQTSNFYPAKGGILAYYSPHMILLRRQVDYSKEFVAELGSYVHGYGHDTRSDHRSRTIEAIYLGPADNMQKGHKLYDLNTKREVTRPQITVLPITDQVIKLVEVHAAEEGLTDLRTYSRHNGEIILDADLLAGVDPDELWDEDYVPADIEIPPVNDMNLRKNDAITDEELEELIEDAAKDILESRKIEDKRQHEYDWADRTVDRMLQRIKRRQEEDNEDDIEMDIDDDKLKDMIDEVAHELDRLSQPIEEEIMFNVEDEDDDYEGEFDAEEIQELQEAEDNPQVYPDKEDDVCSGVRFEEVPMLSTTDDSNKDKTRGTQSGQSFYSNGVKYRPTDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRT3</accession>
    <name>A0AAD2CRT3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRT3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="483" mass="53525" checksum="27838021CB87C562" modified="2024-05-29" version="1">MDDGISQLEVQVAHVENERNCHATKATDELLLVGNSQGKEETVDKSLQIAELSMEINKLKEQLNSSIAANEKLLREKEIENQELKSKCKNQERRMVVLERRNKELQSTIKRLEGPDEGPKEKSRLSSLPSPPITEGNSSEDNSIITSEDEEFEDEDYGSAYYAQHEEYEEENLASSPGTSQRKERSGSMPLGGGGSPKSPSRLLTGKEARRRASDTALKASIGRMTQKQEDEDRSISSLGYDEGSIATQKANANLSRSDSNLGRSTGRRGSDASQSQGRVPRSNRRLSDASQNHSPIAISKRRITASLLREYDSPGTNKTRAAGSMASPFRSPRFLRKGTRSNTKKGSQTPSQAVKKKPEYDKSLSTPDLMSTPRREAAKVRLQERRDAAAMEPQGSSKTSSSPRKQKENSREIKVKGKKGTYTGQLRNDMPHGVGTIVFANGDTYIGNVVNGKLHGSGTLYYVNKKHGIDRGIWRNNDRIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSC2</accession>
    <name>A0AAD2CSC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000391">
        <property type="protein sequence ID" value="CAJ1934807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="92929" checksum="A75B9F9E1DEB597D" modified="2024-05-29" version="1">MNKAIKRSFRGRRTSKVPATVECNADNGIRYYSRRFSNTIHSKDLPMELDAVGLWSPWTLLWFCLFSVAPLAHMYILLMLLRDLCVSFPESIYVPLQLYVPFLARLADRMKGASWIVDFWCVIEALFFIAFKLKYRYLQSRDPLEASLSAAPMYDPEDRKILWDRIIELEKDDLGAFISGWFFDESIENISRYDVCDFLCWCMFDGRNQEHLTSLEYHELESLVEDIEYRISIQLYGAQTEVENKEVDDGESASTDRFEKSRKEPRILSPRRWRMHSEDALTTNSETSSYSTTLYSLPKKNFRFQVDIHREEPTFFSNLYESYKQRYEQYRSLVENSDFHPVKDFRTYLNDRAQQADESARATAHNMYERIIQSGSQVDKQIAALSHATSTQLAEAWNSVKGMKERLETANFLSQKREALMQQLRGNRAMLDRMREMPYAVPSKQMAALMRKITEVYDSLDRVEHLARDGFASATGALAAGKPIFTNREPQRYAKYSFDPLLSVKTFPLGFHLLVLGLTEIPMRVMLGNRGFEKRFIGPLGYYFHPGDVKSQSLKEGGDKVPIVFVHGIGIGLLPYVKLVDCFLKSGRPIFLPEIPYVSGFRPWLSSTSVLTPTVVASTLTAMLATHGYASGVFVGHSYGTSWLSYACKYATNAVAAILFLDPICFCLHTPRLTKNFVYHTPDPGTITYMVRTDMMVNWTIQRAFPWIWITLFIEQIQVPCTVFLSDKDALVPAERMENYFKSKGVPICDAGSVDRGFFDTSGDFNACIFRGSVHGDFTDHPHLLPPIAEACDSLCCRVEEMRKTPMTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV16</accession>
    <name>A0AAD2CV16_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001691">
        <property type="protein sequence ID" value="CAJ1946475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="469" mass="52005" checksum="F1C06D2611E8F013" modified="2024-05-29" version="1">MTDIEGLHSVDSFANRTTSQVCEDIKSMQRAPDPNNANATIGVTARESMTIHCISKYGKLLILVQRTHTPALGTIPNLLFIGQFYDESPDLMEGDSYPLPPHPPKFNNRDGRIMMENIESWARTAYGYCGIRLDYIFREISELPAAGDPGFLRADDGSCSIEEELVRHAAHTGAVFRCNNQKFWVMLHAVTHETDAYNHVRQFAPTLNGRAAYFALFAQYRGRGHFTNERQAAVRVLATLHWNGKAQGFTWNTFISRLIGAFNDLELNVDPRSDANKVDVLLKKTVGDSSLSNGRSHITGDAVLRSNFQGAIDYLRTQVLAAGNDNTQRRNRQLAAFTRGGGGRGGDGRSGGRGRGNGATNCLQSNVPDRFSRNGILLNDGGYSNQIWREEFTQEERNICLEMRRNRRNGGGRGGRGREGRGGRGRGRGISAVHDGQADQEETKEENNNDGRGAGAGMSRRRRNNREDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV79</accession>
    <name>A0AAD2CV79_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV79"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="635" mass="72815" checksum="B6CDB64975175928" modified="2024-05-29" version="1">MLQRAKGTHRSKRRKYPWLLYVAAILILSTGRYILLSALLGTWDSSQVSWSLSLESITTVPAMKKNGASFTIVVLGMDRFNSMKRLLDSLDATDYGSDHVDLVIRFDRPTIIATDGTAGAEWLVQVEEIRSRVSSTWKQGNAIIVVANEPMGLRRSWLEAWKPQDEHERAIILEDDVEVSPIWYRWLQQAHDTYGERSDLAGISLQRQTLIPKMIPIQKGRRNRRMMNKKKNIMVKNKKILESPKEGQPFLFRLVGSIGYSPKASVWMDFLDFANCALDTNLDVSVPDLITSGWYGYFDKTSMWTQLFIYFCNHQKLSTLYYFPPNNRVLAAHWREKGAHLSASYGRDFELATAHDEDLHFPSELASLDWDAKPIESQPTVRPLVMSVALHYGREEFDRFVLGLRKYYRGDIALLISSSATAEIKDLLVEHNVTFLESDAEGGRQFTPKWRRIIKTRYKFYQGMCRPEKYDACMILDFRDVLFQSNPLAQVKVVPSEPTLHVYLHNIKTNRWAKRQVMNCKGAKASWLEDQWFINAGGLIASPSMIAKISTLNRMFGYRCDDQIALNLAVYGKKLSDNSSIIMHKQGEGSINNAAWGGVFHKDSRRRILNHDCFPSPVVHQFDVIEKTKERAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CW42</accession>
    <name>A0AAD2CW42_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS9745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CW42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="8">
        <location>
            <begin position="652"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="7">
        <location>
            <begin position="900"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="774"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="790"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1945601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1024" mass="112606" checksum="6E7A55FDEA7FAF10" modified="2024-05-29" version="1">MQHPDPDPHQDLDDPASSTTPPNSLYSHERGSAYSSRTRSRRYEGMMPHQDTMDQVLDTHSPSMRQIARELLVGTSMRSRKSFVGDFRRSSQATARDSSLVSDAEDSHLISMDQEICHLSYGATMLDNGSLNDDKTLPPTPYSNGSSAHHHSSQISQFEQILNQTTAVAVVCILNMMISIPFGSSYFPVGWKPDGDLSTEDAGTDDEVHGNFPIVAKQALGIRMFLFATFIGQFAFTFSSKFTNPVGLQMVENVPFLHSICNTVIQQQGYGKEALSTVFFLFGLSSVVVGLTFYLLGKWQLGRIVYFFPNHVLVGCIGGIGVFIVVTAIEVTNNTPFTFDWDGLVGFADHFHLFAVALFFELLLRFLMYKTEDADGVAKYPYLSPVYFCLITPAFYLGLHLFGISMDQATEIGYFFPATVDTGVAEAANTSWWYDDSLWDIFQVIDLSTVSWVAVFRSTGTMVALAAFSLIHVPINIPAFAISTDVEVDMNAELMAHGYANFASGIFGGLQNYVTYSNSVLYAKSGGDGKSSSMAIVGLTMILFVIGPQIASFLPRCMAGTLLFHIGIDLILEGVYDSFGNYDILEYTGIWVITLVMTIWGMSAALIAGVIAALSTYAVQSIHHHHPIRQILSATTLRSSDWNRCATARGILEDDVTGRSRILVFQLQGHIFFGNIAQLTDTIKDILKEKESSGEIPIVVIVDFTLVVGMDSSAAHAVAKLKKIVHRLFGVEVSIFVTGSGRGGFPCEYALTEALCPEAAEQIQDAGIDWNDVSTEHASEPSKSRRNESPKSAVNRGSISVSPGTASVAASQLLSKRTGGQVCESLDEALRFAEDILIAREKPSLVHSDSVASCIDISDLAKIEMSLKEEEYHVKKYLKELFSSADELSTDAIEANAELLLSFMERKEYLKDQALWEQGDDSDCAQLLVVGELLSIIEDTGASEQVKFGNMVGELGLVHDAKRLTTLICSSNKAVLYSLSRQNWHIISTQYPQLARMVDAIVIRYLAHRVQHVNNRYFTTTLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWT3</accession>
    <name>A0AAD2CWT3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWT3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="312" mass="35269" checksum="3F3898D9D6E57792" modified="2024-05-29" version="1">MFIKKDLRKIPKILDDAVVCTAEMDTDTDKEDGEERAKRIKLQKPLQELKLHRRKQEFKGTLNILCQPAYLPKLQQLKSLNLYGCDIKDCAKIGMLEACPNLEILNLGRNPISELPAELSQVKSLKEIWLDDCQLAGDFPEPLYDLPNLQVLKLPNNQISRVDGSRMTRLTELRVLCLDRNLLQELPLEIQYLSNLKELFVRHNLLKGTLSPLAPSLEVLHISSNELSDLGTLDVDCPDLKTLYANGNQLVSLPMDLFANCQSLKKMGVSHNQLASVPDSFWTISSCEIVWKPNTQLTPPPSEDVEMEPATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXZ0</accession>
    <name>A0AAD2CXZ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001407">
        <property type="protein sequence ID" value="CAJ1945412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="138" mass="15532" checksum="CA3AD0AC2C3DEFCE" modified="2024-05-29" version="1">MRCNDSGQKHLRSGLVKMEIDETKKSLQARQKQTVALSESSPTTTMKSLLPTAKQIQAVYANPKQLVSPLLQVITPGQHPFADLATVNKVPRGFEKNVTISKPPPQVAVKEEDRDDVVSQYNHRFDEFREVSPRVYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CY27</accession>
    <name>A0AAD2CY27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CY27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="entry name" value="Chorismate lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="Chorismate lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="302" mass="32850" checksum="9FFE981C326E36C3" modified="2024-05-29" version="1">MSVSRIRCTGTRQASLWFLLVLGSVATMEAFAPVAKIYSPSMAAASKSRRPIFLPHPLSMYLGEEGPSMRNENGTPNQNQSDGVNNTTDTIKSSNSSSIGVLSNLQRANGKPYPNSGGNFGDIMSPKSTDANILFRDGLVTSESYSLAEVYGISHPMDRIAVTANGNLQRIVSSYYDAPVEVTLKHCNQIDGLEGGWDRRVDLSVFDQVFCQADSTVQVHNAEWRSLVQSGNMGLGQLFRYQNVLPEFILHAAGPTAEGGFWRNYTLECSSMTCLIHEEFCPNIWDLSPPPTANGGGDDDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZN1</accession>
    <name>A0AAD2CZN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1944319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="240" mass="25988" checksum="DEC4378AE5473C1A" modified="2024-05-29" version="1">MSPVLKFIGKTTSTVVAGTFFVILAWQRDALMVSFFVGAISNGILSKVLKKAIRQERPMMEYVLESSAAGAGSSSSSGNSILEPPPPSDNGMPSSHAMSLGFIGTFTGFLLMDYHYPYSTLLLLVAYASISLWYRIVSKLHTWEQIAVGLSVGTMNGVLWRCLCFGTTQPFSSAVTQDLPINVMEFVTNNLLNDQGVLPLYGLAIPALLGAVIVGSVERRIGRFLKLKSEKQKDAANKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FAU6</accession>
    <name>A0AAD2FAU6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1904546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FAU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1904546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1156" mass="127750" checksum="CF889A9CCAF0B151" modified="2024-05-29" version="1">MPTMPLKSLFKRKRRNKISSRGNELNEEYDPVMVEPEHAAQSTSEQKPLLDAKKAQSRKRFEAAKRMFGSQSTPSEQEARETSVTPEKISRFQPNVSRGVESRRDTSMHQVFPPLQPKDSDEVDLDDVEEKAPEKSPRTPQRHHQIPQARKDVHRLGKEHTLPSQRVAWTGSVVGFTQSSASFGQKQSHDKYSAQSKFSSFAQGDDDTAQYEEIDNKDYLIESDDESNEADESPTGIKQDQYASNDFTSFGESYFASESAKQHNIGVFQNPEQHAKSHRMATSPRQAARQRSIDKQHRNDNSSPLNSAPSMDSYLLRGTESDSVLFGEGLAPSASEDFFAGLDAEEETNPSEHMSTNNSLIDNSLIEEASVSIESRQPDSRADYSHSQFQNDFTNSVRHGWDYLEQAVSIDKDERQGGFTKTVQTVRESWDYLEHSLSAKSADSEFDDMVMTIRQSFSNITEDLATQVERALPSSTLIPDQTLTSRQDDLLNTVINNMSFFNEDSTDEELEQELFGAPKETTNAIKEVPTNPKDPDEILDEVLENWSLTSDNPTDQKEQNSSDFANEVPNEVPSEVPSEEPSEESNEEPDFTNESGFIATVRQTLSYLTDDGGDEEDENGSSMSRSHTEEVKTSREEKHEKKESGGLLKSWSFLSSGSRDDDDSRSASDTSSIGTASDDDESAVYKDDLSVDYSDAPSDEEGLSIGGLSRGQGGMLDQVLDHWSYFAAATGLPEDLDEFDDFDDYSSTHSVSESDESTIVEERRMRGRSRKASPKTNRRQEAAPKASRRKKKSSKSKRRAIPETVFSTVDDSESSVDQDLPPSTGMVVNIPLQPLIVHTSEQVNGPSAAEKTIEGDVVPVAQETEKASAEKEDSSNSDVEDAEAKLEASDEELLKDEQIEEKTDEETVSAESTASDSVEEEIQRAQEKALLALEEEMESSGSAVVTGPVLVESTEVGEPGEYGKMNADEESIESIGCATATENVSVQSIQDADDDVSEVFDADNVSESGLDDAEEIERKTDEDESVESASVESESAATVSESLEDLGHERSYFSESEGESEDGSEYTAEYSDESSSTGPIKKTYSASSMKSAVSSRFGQPGSTTDDINTAAKVKSTKGQTGRVVDCPRSSKRSNQSRKKRNDEESEASQPHRRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC80</accession>
    <name>A0AAD2FC80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1915907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC80"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="199"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="318"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1915907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="618" mass="66815" checksum="1BE220C5F48A206A" modified="2024-05-29" version="1">MSGRGRGINNAPAWMTRSEFGGNKPPPREPDPFGRAPRGEGGGWEGPPRDFRRGPPPPPHHRGRGPRRYDDRLDDRYDDRGGPPRGGFRGPPPPHNRGGPRGPPPSRGPPGPPPPQRNKGGTNNGRITFRSFEEEQEWVEERRRKRLARKSKFDEPPTAEQLAADAAAIAFSNPAATDFAGIPAGRNFDAVPQQTRHARRLYIGNLPAQVTEQDLQDFFRNAIHQALVHKVDNNEDPILSVYINHERRFCFLEFKTVEMATACLALDGIDIHGRGKVKVKRPNDYNPTMAPKVHPSAIPVLDVSRLGIVSGTVQDGPNKIFIGGLHYHLMEEQVLELLQAFGKVKAFHLVKNEPDSLTSKGYCFVEYADPAVTQVAVIGLNGMDLGGGKVLTARVAGERDGMPMPTGSIAMPAAVQAAPATNAPPPGAIIIQGYDVEALVDAAMGQRPMPTAPMYLDQFGMPLTRAQPVGMMAPAVVAAAAPAFPAGASALDIANAALSAAFGSSDGPAAAAAKAPTRILVLLNMVTDEDLATDDEYQGLMQEVREECAKFGRLLGIKIPRKATSSIQASAIKKIFLEYATVQDANNAERELAGRQFGPNVVQASYFDEKDYQSETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FD75</accession>
    <name>A0AAD2FD75_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS1585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000069">
        <property type="protein sequence ID" value="CAJ1928997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FD75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1928997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="747" mass="84806" checksum="8F2C663BFD27FAA2" modified="2024-05-29" version="1">MSYEGGGTVLPDQQPSTETIDQAFLLQQVDFSVSLPSIHQEKGTDRQWQNSGSATTMSSARHANDAVPASSGATSLSCLTMEENVTIGFSTEESGDLVMKDTDTFCQAMAKYDAMLRNQVVYRGLPKHPDTTEIYIKKGRLFWRNGKCAEAVEMYEKVLEINKLVTPGVDPSWVSGAYCHMAENLEFRGKAMKLHRKLFEFQLSTAGEDSVDTANAYDRMGHVLQSFDKIDEALEWYTQALKIRLKTAVDDLDLADAYESMAKKLGGWQSRKVGRDEDALKMWEKALEIRLQILGNNNEAVAHSYEEMADIIRNRIVYDRTGNGEEEAKMRSKAREIRLKIAERDNPAAADALEKMARSLLDGWEEREATKMYMKAISVRKRISGEDHEATIDAYERTADALKYNHWFKHDKSVELRRKVLDFRLMTVGPEHPDTARAYKNTAVALIAIRGNEDEAVRMYERAIEIYMLAAEGDASSIRYAFRGIADILTSQRKYKEAIAMHKKAMDFQLKTVDHDHLDMAETYGKYADALLRVKGKEHEAVEMCRKSMRIRLEESVFDDPILRKDYERLGDCLRRLGGKEGEVVEMYRKSLDLVLLEEGNFGEKAKACLQLATALEKIDGKRDEAIEMYRKAMEMSLQVEGHLDSKAIAYGELASALEKVGGKWDEALDLYRKALKVLLKHKEQGNCGYAVSKVEKRLIFSIQRLEGSNIIDRCWKFCCRKWDKMTHPLLMVLEQALQGGEIGIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGE5</accession>
    <name>A0AAD2FGE5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGE5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="733" mass="77141" checksum="BC6F49B16488281C" modified="2024-05-29" version="1">MSGKGEPSVSKKETSELRSEDREAKHRAKQSGASKGDSGGGKERSSKRHGSDEKSTKRRTKSSGTSTKRRTKGSGASTPGATYERSERMPGSPRDSKRKDKRRSGDRATKPGATSERSSGSSKDAKRHEPRRNGNRPGAAEVDISSADTKADRKARRENETRPRPSESVSNGKSHEDITETSMSSSFHAANGTFTLTASRVPDGSGEEANAGIIQEHSGQTNGTTKPKDQAKQSSKKKWVCLAAFVVLVGGGVGAYFGTRSSSSPGDSSSFGDAGTIPLSAETDLPSGSPTVFGPPSPEDCQAIAEQQPIPGQASLPNQTYYVDLDVDPKSTFNVGSVFAGYVQEAIQSEIVPELVGCKASARKLIRSPGMTSLYRNLDDDLEYIIRNAASDAAIGGVCIEGSDASCQRIIVTLVVTLRDEGVRNLDVVTRIDDSFNDEISLVDKLGLSTVSTDIRFVALRSDDNDNAISPSPVPSASTTKTPTTGAPTFSPFPTSAPRFPPTASPLVDPTPPPTAEATRSPTLVPTLAPVVGPTPPPAPEPTPEPTRSPTLLPTLAPVAGPSRPPTPEPTREPTPEPTPEPTPEPTPIPSSEPSLTPTSEPTPTPTAPPSSSPTPGPTPPPTPNPTAMPTPQPTPVLTPNPTTPPPTLIQNGGACSFDTSCQSGHCGGDFTCSDMKDIGEVCFEDDDCVSGRCATEFPFRCREKIPNGERCGENDDCVSGRCSIYWTGFYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGH8</accession>
    <name>A0AAD2FGH8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS5437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000580">
        <property type="protein sequence ID" value="CAJ1936939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGH8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1936939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="506" mass="54662" checksum="410E418F4A718720" modified="2024-05-29" version="1">MNTDSINTYVVNEFATNDEIQAMSMDIDEAIERLGYGRFQKDILLAAGLCFAADAMEVLLLSFLSIVLKAEWGLTDYQENTVISIVFAGAAIGTLILSPLADIIGRKIIFGVTAATISVFGILTAFCATYEWLLFARFMVGFGVGGLTVPFDTLAEFVPNSQRGANLLEIEYFWTAGTISVPVVAWLTLGDSAYFESWQLFVLICSLPCVASAVTAVLLVPESPRWLVAKGSHAEALRILRGAAARNGLDPFEVYPNGTKILELNQARESVCDLFSAKWLKITLLLWTVWGFLAILYYGVIIAVTIVFSSQVEIQDDNSQEASYYFDFGAIFISASAEIVGLLMAMFTIDQAGRIKTQTFSYLLGGSSCLLLLLVASINGPRSVLLVFAFTSRMAMMGASCTTWVSTSEILSTDIRASGHGTANGMARLAGSVTPYIINDKASLNVIGLFIFSISVLTAATAWHLPETAGQAMGGVHGTRRNEAKLGKIESHNQSSAATAPYQTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIS4</accession>
    <name>A0AAD2FIS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M41 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIS4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33471">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33471:SF7">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1942640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="57415" checksum="A572CD6042AC603D" modified="2024-05-29" version="1">MTSENSSCFLRFQRIRIFFLLASFTLSKSFVHRLPSNSDSRQVQWKLRSEPSTLSDDTAVKKSTDILALKRLDQCASGSAAKALLEDFTGDGSLYRSISIPAGASDRGISDGDLAIQTKIRNKKYGIFDLIDLNGNRDADRASAGVLGVFLASSFSAIAANQNLPGPEIFRFVVVWILSFAPLALVGYGIATPDNLQALLVSIQRELFPTYRKRMIQHEAGHFLISHLLGFPIKGYSVNAVKNAVEFYPLSDRDAGVQRAKQLGFDKPINERVEDFFEPPSEDVPYFSKDGSGGSIVETQSVFRNAKNYTDNPFLRLSPRDEPRESWPFRGFNHQTIDQLAAISVAGVCAEILAFGNAEGGVADFSQLRQIFSSAEPELTEREMENRIRYAVGYTMTQLRLHLGALDSLAEVMARDGTVSECVAAIETCENVSGADAIFGDYELRRRKEFKNLGAGIIEKLFLGEKNADTEEDRLIEGKGGGYRKTKEPLIKITGDDPLYIALGISCLFVAWATNGGLSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIT5</accession>
    <name>A0AAD2FIT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000355">
        <property type="protein sequence ID" value="CAJ1934652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIT5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="337"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="709" mass="81958" checksum="CC1C0636AC479777" modified="2024-05-29" version="1">MIDEVARELDRLSQPIEEEIMFSVEDDDDDYEGEYDAEEIEEMQEAEDEPQVYPDEEDDVRAGVRFEEVPVLSTTDDSNKDEKRRTQSGRSFYSNGVKYRPTDRNQTDKPRHGQTYLQRKKPKINLLKNRSAMRKKARLKRLHISLYQAIASKIRDEVYTREVVSFIQRYYLNKGLKIFKERGKEAALKELDQLIKRSCWTPISIGELTESKKRKAVDAMMLLAEKNSGDIKGRFVYKGNETRDWLSREDTASPTASHEGICCTGVIDAHEGRCMMSMDIPNAFIQTLMPDLGDGEDRVIMKVTGLMVQYMIDLDPTYRDYVVYENGKRVIYVVILRAIYGMLQASLLWYQNLRASLEEYGFVFNRYDPCIANRMVNGKQLTIRFHVDDVLASHMEQQVLEDFFTWVNEKYGGLKEVTCTRGKVHTYLGVTLDFSKKGKMKIRMDDYVDRMLSEFPVKFKDNEVQETPAGNNLLEKGKGAPLEKERHEMFHSFVAKSLFLSKRARLDISPTVSILASRVQSPNLGDWHKLVRLMRYIHSTKGWHLTLSADDLRVIKWYVDASFAVHPDFKSHTGAVMTMGTGAVQAITRKQKLNCDSSTHAELIGVHDAMSNILWTRLFMEEQGYPIEKNILYQDNKSSILLETNGRSSAGKRSRALNIRYFFVTDQVKLGNITIEHMPTDEMWADYMTEPLQGEKFRKFRAVIQGEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ61</accession>
    <name>A0AAD2FJ61_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="471" mass="53743" checksum="4B82EF474413B839" modified="2024-05-29" version="1">MVVKELKKPQRKWNLGACLVKVVYVITIGYFSVRVFFLNSHIISLHNTTPLAGSLESFMNLSEAFTASASSSYSSFISSPHHAAVHERIGASSSAAAALSAEDHFLHLPKWMQEYFTWHKQQRSQLTPETWNKNKYLILGCRKRHRCGGLSDRMKPLPLFILIANRTQRIFLIHWDKPAALEKFLQPPMQGANWSMPEWMVQKIDHHEIDQTLKRGEKALTHLGEDGTTAVYTQLQDFHGGSFIYDGLIAATYEQQDADDETVNNKAPAADMKKTHNDRYHLIYHDLFRYLFEPSPPVSVLIDEQMKKHNLIPGEYSIAHYRAFYAKEDKKDIFSDELLQKDAINVANCGSELRPGGPIYFASDSRVAVQAAVSYGKEHNRTIVAFDGPEPVHIEKEWEGRNVSEFYSIFVDLYLMGNGRCVAFGRGGFGRYALMMGYNSTCELRYLYKGRKKSCHWTNLGPNGERVYPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJR4</accession>
    <name>A0AAD2FJR4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001280">
        <property type="protein sequence ID" value="CAJ1944956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJR4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="444" mass="50134" checksum="AE8203CD32583D88" modified="2024-05-29" version="1">MASFAEVFLKSLPWRPVKTAGRKRKPHPSESHLVNEYQEQSLKETMCCTAQPSASFKNYIDDDIEGGMSTSADTSKAQMASFAEAFLKSLPWRPVKTAGRKRKPHPSDSHLVNEYQEQSLKETMCCTYPNLKNQFHMKGIGYYPLCIHLNDVYSKSHPFLKCVFGQKRKPSKWDINMQMFLFAINALCSRSTKREFALRSVAGCTDNQLRKLKPGPILRAIPDIVPTNGSKSAKLLIKVKTDDTLPRAIQDLVPANDSERGELLIETKSPAAFLIGIQDIVPSNNSESGDSGISWIEEANEPEVAVDLLPEETMHKEDKLVVEIFCKRLAMDKNDKSSIINELCHLITSKTLEESKTSQEQISKLSFKNTKNRVIEKHYALLSQPAKDFTALTQSAKNQKANHMKNIVACLVGSDIAQQQALLELVYRKFEDLILLHKEDFKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKJ7</accession>
    <name>A0AAD2FKJ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS10522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="3">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1946378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="105" mass="11475" checksum="0BCA0E31849AE8B1" modified="2024-05-29" version="1">MVRMISDMDEWNALMEISKSKAVIVDFTATWCPPCKMIAPIFAKMAEENPEVEFVKVDVDEANDVAGMCGISAMPTFQVYKGGAKVEELRGADPKGLSAMVAKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKM4</accession>
    <name>A0AAD2FKM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001546">
        <property type="protein sequence ID" value="CAJ1945850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="402" mass="43428" checksum="2678329AEF2ECF4D" modified="2024-05-29" version="1">MLTKVFIPKYCKQGKGKSLLQFLYAIQCIPAVKKLPPAQPEQPATLDAKTPDLPLPPSVSSTPPELPPTNPSVTAPTTAQPTLPGSSTKRSSRKGSKNHRAKQPLEKPTETPQATPPTPLPRPTPALKSTPQAATNRPTASSAREKLSASEQPLVTEAFDRSAWLATMDAELNQGPAGLFQMILPGPIDGFYVFVVRQKFASLAQEVLKNLATFLISHLELWQDLKHQWKTCRTWLCLDHYNRTVTNAMTWDQSQHRAISEFERDVDLDQQVEKDDNEWIEKLLAAKQASTEFEGTITIDLLMPAAKDMDDGATVGSAANMAALLENMKADVNDLCMELETVAEKLAQAKDAEAAKDACILELEAKMAAQALVTGKHRSSSPSSSKATSSADSGGGPPGGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKW3</accession>
    <name>A0AAD2FKW3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001640">
        <property type="protein sequence ID" value="CAJ1946180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKW3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="119" mass="12608" checksum="E5DDDD0C0B85CC8D" modified="2024-05-29" version="1" fragment="single">MSTTEEPIAPTEAGAPDAREQMSAELGMIGDISETIEEGEEDEESEEEEEEVPSPAAAAPGEAAPTEAATAEGANEEDKPKKKKKKKSKGAKFMNKMAQPGVFMAKQAQKGVETMVINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM87</accession>
    <name>A0AAD2FM87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="264" mass="30180" checksum="6859A72673C27F35" modified="2024-05-29" version="1">MAPKDRQVSIYDSYSNCENECNSGPLSSHYRRKLNRVSFHPTVDLKEIANRNDYTPTEVHACWYSAEEKELMYESCETVVDRMEAGKRPKKNTSYRGLENFIEANASQFDDTIHAYIDAVMDEQERQWDNDMFDCELLREVALEVSLYSASLAHKMAAYDVNEARKAYISMGKAHRKLQDDVSISTEITEVSRSTMVHDIKAKHNKTKRDDPSAGSSKKSRTEKKRSSSRPPKSHSSGSPKAIGGPLESFRNKVYNTKTGERRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM94</accession>
    <name>A0AAD2FM94_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="18157" checksum="EFB149C051CA93E0" modified="2024-05-29" version="1">MVLHSDIPPHQPLEKSFQHSRSYCLRARRKRSFTYQPSEDSFEQATRLLRLFHAHEAHSLDSILEHPEDDTDCEYDAPVFFPLSQRLTKAKTVPCLSNLTAEERSSQFEMGMNGEDRESSSHSSTIEVRQTMSIPEYSENRDEEDNNDDDDDDWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMI1</accession>
    <name>A0AAD2FMI1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042121010" evidence="1">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="107" mass="11973" checksum="1C4A3560F7A4F430" modified="2024-05-29" version="1">MMNSKLLSLLVVVLVATLASARRSSPSSGVRAFWGRHHRVSIPKLFDNRQVINNNYNYNSIMESKMVAFTTSSSSSSSTADEDDHVGQPIKKLHTQEELVYLSFHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMI8</accession>
    <name>A0AAD2FMI8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001543">
        <property type="protein sequence ID" value="CAJ1945836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="186" mass="21134" checksum="3F3C7BAD5D9402DD" modified="2024-05-29" version="1" fragment="single">CSEESTNSYLDRIEDYLSWPNIGGSYPELQQVVQTYAPSNQDCRDLYLQAQDSTLNPEGMAANDQNKRIIQATIDELLVIEGGKAFFTVLNEKAQICSLFIVPTQKLFEIDQMLNKLLKWKGMDFNDGKPRGLYTDTWPNSKDYWEKRLAPNTEGAVPFQSVTHEASKFAAQTFLADQREIPKGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNR8</accession>
    <name>A0AAD2FNR8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS10999</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000933">
        <property type="entry name" value="ABC transporter A family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="741"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1241"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1844"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1890"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1928"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1964"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="861"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="2169"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1947143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2503" mass="273852" checksum="7F486E4F74C3D70F" modified="2024-05-29" version="1">MASEAEASAPITTAPEEFSSARKVPSEEEKSVAEEAAALAEETAENGDNEAASNGADDADDANDAVEEAAATADTAEEDPPSETTKAVASDVDKPKEESDEGSEDENENEETKSSEEETVQVVAKAVKDEPSSQPSSSAAASDNKDMKETESGFAEEDSPEEPAKASFAGIATEDASSVSSARDVEKDSQTVGSQDSDPASTRRGNRQASSLSQILALIRKNILTKLRTPGATFFELFSPVLMMLVLSAAYTLTEIEYEDAAMYASLNLAFPGPWIDLAQRTQSVFPGSDMADAMGRRRKLKKSTRGEDPNLLVQMMNSDTSDDEKTWDGIFEGLQQKMEQIMLKHTQEIASDEMDQQSHNRRLQTFRNNVDTSLDAEVESYELLDDARDEIRDLLQGPIPTPSFSQFVSISTALFNIVPLDSLPRIFGETSFGRQWGNLLTLGTLHLSPRNQAAEDFWAYLNETYPVIMLATSGTNISNFRVRMHDDEASALNYIEATNGEERTWALLDFANFDREQDSNSYQIRLNYTTVPNVNEITNWANIGLSRRYQRYYLSGYMTLQRTINEFAFAQSGCDQDLSSIMSMPMPTAAYSQNPFFTQVGYLLGLTMAMAFLYPTSRFIKTLVEEKETKMKETLLILGVRTWAHWMSWFLTALLVFIIITVSVAFTLSATVLKHTDPAYLFAFVFLFGTSTIGFCFAIASFFSRAKLAAIIGPIALFATILPRFVFFESNRYENVTGQILSSLFPATAFCFGADIIADYEYAEQGIQSYNAGEGGYSFNTALLMMLADTFLYIFIGWYLDQVLPQQYGVPRPFYFLFLPSYWLGECAKKDGGKAEIFPDIDNESPDVEPVNDTNLIPKVQIRGLVKQYFKGKTAFPPAVDGLNLTMYESQITALLGHNGAGKTTTVSVLTGLFPPTSGDCVLYNKSIVNSKQEARQSLGICPQHNILFDELTVYEHLAFFMRIKGLHPERNKILGHAEEIGLTDYLGTASKALSGGNKRKLSVAIALSGDPDVLILDEPTSAMDPHSRRAVWELLRAKKKGRVTLLTTHFMDEAELLSDRVAVMKEGKLKCCGSPIFLKERFGLGYSMTVVLEPPAVEGDEEGGPARPSENVFLKKRENVLGFLNERIANTTIVRTSGKEVTFRFPQGSEVSFPGAFDDIEINKDDLGIGAYGIQNSSLEEVFLQLAESKSDELEEASSPSETPDEVIYDGEYSHLSPLGQIGLLYGKRLSIQRRDKKGACFTIIVPILVIAVVLVILTVRPPNVYGRLEMNPAMFQTSNGGKRNSATNIVISDRLSSSSALEDASEATDLFMESIKTRYSNAEFTLDTNTDSSMGLSQFLLDNYNNRDHATRFGAFVLNDMVNFTFGLDVSAIQSLIDTAGGLQSLTAGIEQTEIELISLFGLGDENGTLNVAVNLTDLPAMISSFGITLPSVTIDVPELTELVDTSLGSMLSASNMTDLSLGFLEDYLNRTYYFSPDIELQLPGIGNLNQTTSIANSNTTGNENSTKMVEDNMTVDDPLASVFDSKILQIDPFDLVSFIQSSGPYNRSTLIRAIDSLLPFVYESLGVQTNATMIPSGSSFFRLLDNVTAQLTDTDFVDDNLFGNDTFFGDNSFFNDTLLGDIGLFNGTTLGTNITLNGTTIGEIPGTGYFEQLNATDSEQLSNAIAIAATVILRESLSEVAYTNTTFDFSEIFSGLLSSVGYNGTLDSLGLPIDGDDLFDIRLQASSITLELPSFALNIYNLTLIADEDLPVLLPFASFDLLDVALDSLGPMIPEEFVMPIEAQTSILHNSSSPHAVAAFNQAYMEYKYGQCKASDTVTLKSINAPLPITAQETIEIKTILSVVAALFLLIPYCYIPGAFSVFIVKEKISKSKHLQLVSGVNMTSYWFSTYLWDMSLFFLLTVFIMLVFLAYGTESAAVFIGDIEAFFATALITLGYGFSILPFSYLLARNFDNPSTAQISVIGLVFLTGFVAVNAYFLMTALEDTQALAASLLPLFRLWPAFNVGEGFIELSSAYWEREVLASEKRPFDWEVAGRSITLLYGLAPAYFMILLFLEYADDGGSGGMAGRIVRYVRGSYERTVLAVHGVKKVGNKLTLDDGLVDLAPNDDVKKEADFVNRKPELHKSAPIVLRDLWKVFPPSIGLLGGLINRIKWLLCCCGLGKGSNQEDESNSDHSGPRRAVRGLTAAVQRGETFGLLGANGAGKTTTLGMLTGDIAATGGEAYVAGHDITGATPGGVQEARKNIGFCPQIDPLLGLMTGRETLRMFARLRGIQANRIEEVVTALLEKLTLTPHADKTADSYSGGNKRKLSLGIAALVADGGVLLIDECSSGLDPLARKKLWGLIEKLALERSVVITTHSMEEAEALCSRIGIMARGQFVALGTVQHLKTKHLDGYAIDISLAPNSSEAMIDSVVEEICTRIIPGSVISERHGRFLKFDVNKVSTIGLGTTFGRLQELKESRGIVENYSIAQCSLEQVFIKLVKEAEEARNVTPDIAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP24</accession>
    <name>A0AAD2FP24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001738">
        <property type="protein sequence ID" value="CAJ1948061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="528"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="668" mass="76571" checksum="B931D8CB2D41DCB0" modified="2024-05-29" version="1">MSNYHFFPMQYEPIEGENLRVKVDIDHSTFSVNLKKLDITQMSLHKCVDFAQTLLDDVTLEVGRNDDELLGRSLNKFWSKALPPLEQQVWEALPNYMDMDEESVENCKNKVRDWILTKCTEEDAAAVLNQLRTWRKPRSATIMDNQMYMKKLNSAIPYMSESLDPLDKEEFKRVFFNAHPKPWKDAFLEINGTIDSHSVASITSYMQRKARQAHDKELKNQLHQKIKSKKKKRTAGVHHRDDSKPFKKSCTDPEENKMDKDEYHKRVAELAKRAKPTKICLLKPSHKNHTISKYKPDDDSTTSKETDSSNKNDAFYMNNESYYVPAFSHHIDFCCFDSLFDPGSDESYIHRRMLPTGINGKTVKKKIGTISGKQSLTKQVINIEGIVFPEFSPTQQVESTFETIVFDSDARYDMIIGNNILLPLGIDCCGSTKTIKWMDKHIPYKPPESCLSPQTTDPNEDTSMLMAQLMATHCYHSDPDESLNEHIEQQISHSFNIAESKYDLVPLEHVAKQQQHLNGPKAHLKLLPTQLLQPTIQWYHAALSHPGSTRLKDTMRIHFHNPKLSNVIEDFTSKCDTCQRHKAVGRGHGHTAPKEAPLIPWQQLAVDLIGPWTLMVAGQEIEFRALTIIDLVTNLVEIVRIKDKTCANVTLQLLEVSDPLPPAIYLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPC5</accession>
    <name>A0AAD2FPC5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPC5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="150" mass="17005" checksum="F742229AAE2CD186" modified="2024-05-29" version="1">MSPSSNSKDHGQFSVNDADNSSYCDNHSVSGDDRQEERRLTNSTSDDRQERPTTHDLPMEFISADRWTNKNTTRPTTCNDITAQRMIPLVRPPPSSLFCMMSSAPKRLRYDASPEERIEYSKSIIDEALGIIHGRKDDKLASNATMPQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPU6</accession>
    <name>A0AAD2FPU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001751">
        <property type="protein sequence ID" value="CAJ1948705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1948705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63514" checksum="E1058677AEB39FDC" modified="2024-05-29" version="1">MPELTPNAFSGGEGFISRITSKISDGSEISVDDLGGLQQLLSRSASSELPTLDKDFLKRQIDEIQIVHHVGMVQNMLDPEFYVSSLNGRSLHFRDCNPTSNSASNDTGEDFSNLSERQPLFVVPIPFTAGWFKERSIVRGTSIERTLTAESMMASASRKRERETEQSKKSKRCSESAKEIVRMNDSDASKRAKSLKQSVKWWPAGCNGSDDSSSPVLAKFYYDEYMKADNRPTTLRLNDIVETIGVLSMNPWEAEFCTADSDFVFDSSPPPPSQLPRLHVLAYRTIDLDTLAHERVLNLTEMTPEMMGGTLDGGLKRSLAAQAIFLTILSKAERKDNLIHRLSTSAVGCASLKVSTTVDSKEVFQRLKNILHQSCPVVAALDLASKELHPFPAKLNGIIPATSWQLPSGSTLLIHAGDSMQDGLEELLTSHQIVYTFEGGVQIPFEADYSIIVISNNKTVKCSLQVYCDEEDLSRLEEEESRLRQALSACRTVGNVKLSPEVLERAQDDFLSQRSSARSNPKARMPHEDDFHRWLCLTRLQARSRRSEVATTEDWEQAVALDDAIWNSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQA5</accession>
    <name>A0AAD2FQA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS11980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="473"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="772"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1949209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1149" mass="129213" checksum="727E935248782449" modified="2024-05-29" version="1">MFTKSARNHKITSSRQPQRLTMRLLGKISNHDLLDTDEESQCLNRGFLEPSPPPSLLPSKEPGFGVDRRELTSARTSVSTPPVGDDDSSLSLTQTDSPIFAFQEEEGGEEEEASTSAPSTTTLKKAISESFQQAKAYSYKQLLAPGLIVLISIAIGVFLKLATEQAETRLREKVFENQAKLLSALWQARLKETVGHSGIIWESVFDQSPIVTPMIVVMNNSCKENALTFQVGQTKAAFLGIGELHNPDLSDYGQCFGLPKYTKGSDLISQCENIAAIYPTKETVSHFSTNQSDIAMASFFIFAAILTAFIICHDYFLRKQIERLSNNFHQAQEIVSSLFPANVQERLFQMHSEPSVRLDDMMLTPKTTHKSTPERVQLELTMEESASSFHCEAPPPPPQVDTLESFDLVEEVELANKVLESKKSGGSERSKRSGTPSQKLQMFLSPPQLVSGVSEKIKCVKNEPIADLFPMVSVMFADIAGFTAWSSEREPAQVFRLLETIFHCFDKLANEYNVFKVETIGDCYVAVTGLPERRDDHAVAMARFAHECLTQMNNLTRKLELVLGPGTAELRMRFGIPSGPVTAGVLRGAKSRFQLFGDTVNFASRMESTGRKNRIQVSQATANHLNAAGLESWLYPRGDLVYAKGKGDVRTFWLDRPSTSARSVVDSSTGDSNSDFNLNKAGSTSTLIELKSKSKSVLIRGLSFQPNRDEPSHISDKLNERRDKLSASIHSNNKWNQVNEKYDSVREQLALEEAISGEFSDVGRQLRLIDWNSEILSKLLKKIVAVRQTQCSNQCCEDVDPRSYSEPKYLEEVREIIPLLSEEDMSKENWMDVEKLTNIDIHGIELPPNAERQLKEYVTTIACMYRSNAFHNFEHASHVLMNSLKLLNRVIATDQLLLRIDYTCAISSDPLTQFAIVFAALIHDVDHTGVTNSQLVKESAHIASLYNNKSVAEQNSLDLAWELLMEPSYKDFRPCIFSTKSELQRFRQLIVNVILATDIFDSDMKALRNSRFSKAFHMESEGTSLTTENELNLKATIVIEYIMQASDVSHTMQHWHVYKKWNEHLFAEMYSAWQVGRLGFNPSTGWFQGELSFFDNYIIPLAKKLEDCQVFGAAGNELLKFALENRKEWEKKGKELVAAYIQKYTSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQC5</accession>
    <name>A0AAD2FQC5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQC5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="187" mass="20658" checksum="CBF9C66B8AE6BA32" modified="2024-05-29" version="1">MKTVQDSEGFAAQSTYIALSRACRLFLQFWMTGRGPENQNRKQSKVRKGEVSDVDEHGFNIKSPIAPKRTQEMNVIEALISKSKLLEPTEGRTWAGDGGHEEMWRNANKIRMAAKGKQKEEERKTSGVEGGMREETNESILEAEGEMHVDASDGGLCDTIGTYYPPTKATAPNKNNPVADQVGDIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQE8</accession>
    <name>A0AAD2FQE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="4">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS12128</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16266">
        <property type="entry name" value="IF2_aeIF5B_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="386"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="108"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="252"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1949502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="984" mass="110074" checksum="D1678AA1CC88643E" modified="2024-05-29" version="1">MGKKKGGKKQQQKPAEEDDWEALLEAEASKNAPAPAPAPAAAEEPKDEPKDEPKEEDATTAAASDAAAAFLAAQGLAGGDEGGGGGGKNKKKKKKKKGGGAAAAAAPQEEKLSARGKMVQERLRQQREEEERIKAAEEAERLRIEELERQEAEEERKKEEERERKRQKQKEKIERQKREGTYMTKAQKAKARLAEQRLQAMRDAGMLPVGEAPKKRSVYDDRKKGKEQDEEESQQPEPEEPKVEEKAPNPEPEAEKEEEKPAEDDDDDDDDWEKMDSSGDEWDADSDGGDDKFADLEARLEKVVLEDEDVDLIELEKRKEQERLKELGKKRAEQERIEEEKRKKMMLEQKAADEKKMMAEQKRNEGRRKRELQEKVNLEARSPDDLRCPIVVIMGHVDTGKTKLLDKIRKTNVQEGEAGGITQQIGATFFEKKTLEAQTAKLNVTEKFDFKVPGMLVIDTPGHESFTNLRSRGSSLCDVAILVVDLMHGLEQQTIESLTMLRKRGVPFVIALNKVDRCYAWKTCKDTPIRDALKEQDEGTVSEFRSRATDAKVQLQEQGVNSNIYWEMGEDDWMNSDFVPLIPTSAVTGEGVQDVLMLLCQMAQRKIWKQLMWCANLQCTVLEVKAIDGLGMTVDVLVVNGHLREGDRAVFCTLNGPIVTEIRGLLTPPPSREMRVKSEYIHHKEVKGALGVKVIGNNLEKVMAGTPVMIVGPEDEEEDIKSEVMADLTKLEAKLSTDKSGVLVQASTLGALEALLQFLREETNPPIPVSAIGIGTVHKRDVTKISIMNEKGHPEYATILAFDVSIEREAREHAQEMGVRIMTADIIYHLFDQFTRFMDELTAKRREDAAAIAVFPSIVKILPQHVFNQKDPIIVGVEVVEGILKVGTPLCIPALGGLLIGKVISIESNGREKNTARKGESIAIKIHNEGNPNITYGRQFDATHNLFSQLSRASIDALKANFKDALENEDWRLVVKMKKVFGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRS6</accession>
    <name>A0AAD2FRS6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRS6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="239" mass="26726" checksum="571522883DAA3303" modified="2024-05-29" version="1">MPIPEPPESLPGESTSDAQLSDYEKLRAAKIEKHNALLRSLGLISAQEELESNALAWHKSLPTNAKRKRQEDATGNPQKSSKLAAKTALPPSRQSLRQRGKEPDGSEVPPSLKAESIQEMRQSRVLECRQVRLERARQYNDKVTNGTGKMNRADDPTGKLYDHTYYRIQSMTDKALEGRIKAIERAAGKQCIIKMAIFKSCLQDVGMWKLAELAGGALERLKESSEIEEEKTTKKKGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSP2</accession>
    <name>A0AAD2FSP2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="277" mass="31151" checksum="D961E4324CDB9E20" modified="2024-05-29" version="1">MPFHYLSSPGAFVPAYPASPQRNGFDFMPSPTFTGLSELHGVRLLDPASQTMCVGFFSGFTTPATLIAGTSFAALFALSKRVKDTSFRTRREIMCLRMYHVFSLLSLLLSLMTVLGSQAALHCLLCPIAMPKNVAATSIYEVLQSTMNFEFLLTRWSFIMSILCFLQCTFFRMVVEFDLFFKKSRRTAATMVTSAFMGIGLALLGYLDSFESLAKWPSFWEMTKELGMIIWTKIEVERHPLQIASLSCFCIALLSLCKFLLPGSIEEEKLADNERFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT73</accession>
    <name>A0AAD2FT73_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein MON2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="3">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1707"/>
            <end position="1748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1952394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1753" mass="191601" checksum="B30DF8AC4D4E4634" modified="2024-05-29" version="1">MNFVAQLEEYLRDLGVESRKKHPGVKEASERAILKLRTLQNDYVIAVRKANNGQKHPDTSLFRSSDLLHPFLLAANYPNASPKLLDTSFKAMKTLMEANAICPGDGMNMVRVWMIQAQVVVNNSTKDSGGANAASAASSGDSTGGAQSSSGWLGGLLSSPITERTKTNAVTIGAVSSSHGGAGSGRISAKDLEKLALDILSCLLQLLELKDLAVSTEQWVQSVTLCCLLYLPTRQNVRQAAHSTLPQVLSLLVKDEKAKDLALETWYDLLGGAISSDSGSDSKQKFKGAFKSCKFGDKDSPQPPSSALSIELMTTLLKEAPHLVSDVGEKTLQITIELLRIQSASKDTSPLAFSKGVQFAIVVLQTQAKTWPKQCRDLVARLIQPIPAATEALRKQADFEDGYVYSTADKNLSAPTGNLETLQGLPPGSLWKSALSLEGLHGAVQDERVRDLLLHPDVVVNLLEATSDFCTIGASCREHIHLFILASRKKELGLSYAAEALPSISPWKSGKGRDENYIIGDALWIGLNLLLNIVERLDSITLDTCFAPSLSVLQHYLKRLPASGTIVKRSLEGYYFLAKICLQKPLLRRVLLSSLCKLSLPKWGTQDPSCELKDNNIAALVCLLNVVHAFHDDIGSDWAVVLQTFDELSNVWIASPHLSDKTYVGALSISAVYSRFSQFSTCFSDESLIEFIKGLRSVVIIEEKARASGKSIRKVDTSRIASRSNKDAVGKDEKGGIGEKLMTIGVRAIYGGNEDGSQPADDVPLTERTKNTYYHDYQLEFAKRMGDSKYPFRHEMLPFCCSLLADVAMANRFRHNRVAGSLLTELCATASESELTSAFAMDVVSMLIMSHLSQSEDLPMSFAGPGKIVYEVPRPNQFLAVEQTSDPDASGLSEISQLDLVGPLCDLICSAEDADVTTCCMESLHSILESSGHVLAPDAWKKVIQAVASVSTSSRSSSDWSECFPLGFRCLKLIVDDFLEDMDSASHVREALLDCCWSFGISSQDMNTSLTSIGLLWTIADQDAGTSSIDRALEKLVNLSSDPRAEVRNCAVNTLFSCIAGCGQTFSATQWQACICNMVFVVYDCVMDQITMDGKGPDEKQGKGETGRYRVSVHHSRDSAGKQWMATQAIVLGGLSRLLRSFFLDLLDTTSNDSAGNEPPWFEKAWNRILSYAFDTSTLSGGRDTIPVRSAGVQLLVICNQLACKAGIQAAITPARVGTNMQVVNGALRSTRDATTTMADAQRAPLSEMAETWRENLFLDAFDVLDSFRVYLESDVSAGSDSESSGYMEPAQAQVLGHFANDLKKLYECCKDHEFAEGHKVDHDALLQKVLVLEQPQPSDEDALETRFVRIVTTVCYNSSGGPQSRFLSQAQRACLELLKSMASNGSLEAFVCLSSLCFDGFIRQEVDNNRVSGEIAVLTSTEASNSLFSALPNDCVSDEIRVMVLCRMMLAFVGEQNQSYSVLESGNGFLYRLFKSMIGPCVTSAYTLQKQYWTLEQQGSPMDQLLDLLWDRLCAVVARLLASAFQNELSAQVFNDLTVIVDGISKYPNDRYSPALCGVLATEAMNCLDLDLPPPPPSEEEKSDEKDYSNESLKLFGSCFGGICRLNPEEKILPVIAKQVLLAAKEELSKELEDDDNDDSANADDRTTRKVEACVIMCQSMEDTLGMELVVISVFPLLCEMVGASDHRLRDSVATVLSKVNVGHALDGIKGQCQAAEDRAQRAEEQMATLRKEMEDLQKENEALQRQLAFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV21</accession>
    <name>A0AAD2FV21_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001821">
        <property type="protein sequence ID" value="CAJ1953171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV21"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="16841" checksum="B11E7E035111B9D3" modified="2024-05-29" version="1">MANGFLYNSNRAKCQSRIDGMTAQCTLKHLDFKQRCTFPTTLENAADVLNQHKHDNRKKNLNGGNSNQQGKQNKSNNNQNDGAQFLQQQTQACFVCGSKAHVAPQIGDKLKPWEKWKSPDEYRDYLDANGHGNRQNMQRGDNELGDSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVX4</accession>
    <name>A0AAD2FVX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Inward rectifier potassium channel C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS14896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0630">Potassium</keyword>
    <keyword evidence="2 7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <keyword evidence="3 7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1954303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="68500" checksum="F3B1A9599AC0A023" modified="2024-05-29" version="1">MDGDSELQSPIPQNYKGAVNSQHSRQHSDASSSLPKDDKASSEGFSLKEVDLRIERLAGGGGVEHNRTVIRRRPHEVNAMSNKQRWELKRKRWLKRLQFWNPTDGTEGFSEEGHDIPQYRLEGTRKGKRFRKSLLSLMCGSNSSSGGIGISHNQRLASTLHWMFRVNFLFLFTVMSLAFFGLCLLFSALIISAGKLDADCIKIGGISFGNTTASFFADAFALSWTTLSTVGYGSTYPALGHENTNATNCLYITTICSLESFIGVLYSGFCGAILFGKVLRIQSHAQVEFSDPIVIRYGNGIEVTHHDDEDDETDEAFKIPCPVLEFRVVNKLFAEDGGEIMDGTLTVVANVDANDFADDDPGSTDHSVSERLSRADSFNSKESRKTARRRSTFANAAGSAIPTGIKEIGSGIGTGIKNVGKGVGTGIGHVGKGIGNVGKVAGKGIGQGIGHIGYGINQIGKISGIGELVGRRDSTFDEQDPTAKLANKRMFSKMLIEPGDHPFFKRVWIGRHVLDDTSPIVKPKVKRQIRRNKGYWPVRLNNHEGVRDSLQFNQILVSLNGVANVSASDVYAQKIYDFVDINIGYQFVNILYKDKDKTLKLDIDLLNDVREQNGGGGEPLLLGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWH0</accession>
    <name>A0AAD2FWH0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent FMN reductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="229" mass="24218" checksum="A33329A77241E213" modified="2024-05-29" version="1">MSFSAIAKRSFSSAQFRKPVIALMSGSTREGSVNTQLIYAAEIVAKGLGAETKVLDLGNYDMPVYNQDFEATSGLPKAAQQLKAELESADGWIVASPEYNGFVTPLLVNALTWCSRGDPDGEMYATFKGKSAVVLSASPGAMGGMRSLNPNRELLTNLGVSVLPDSVAVGGAFGAFDDSGTLSNDKQKAMLQAAVEKLYYQGRDVANREATCNMIKTHLVGQYGEAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWQ7</accession>
    <name>A0AAD2FWQ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
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        <property type="entry name" value="UPF0148_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537:SF1">
        <property type="entry name" value="PROTEIN ZNRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537">
        <property type="entry name" value="SJOEGREN SYNDROME/SCLERODERMA AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955213.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="873" mass="98942" checksum="9F6983FE695FAF10" modified="2024-05-29" version="1">MLVEINNSVIPQQQQSVLGEDRLEDLLSEKLMEGFELDETPCPHCSTPLVKMNRNPYGFDIKHLKAPVLIPNRNPEKPFEPMDDVPVCVSCNAHVVTNEHEVNILTTGRPNAEQRDPSPKSTDAPVIDLTAVLSGDEADMTQLPYSVRRDDDPERNINRNIRNSSTPTVGSYDEGRVRELNLLEKLERKRNEQERYEQRMAKNPIQVETLPEDFPEMIEEVEGRDDVEQSVRSHTPSVRDMMFKREQQQQLEEEYRATLRKRREEETILMEETKRIIAIEEEYTVGSVRTTDVMQRDLLMDQHRNRLTAKAQLDEDVLKLEQMRLVEEMEYRRMTEERRAEDEADMITHLEEEAAAKKKAAEEAQERAKQALDEVKKTRKDLIAQTIAIAEAEVVAEAEECLKREIEEYKEPTLLPTASDVEAEHWETLRFEGRTVMTRRVMAGWTILAEFCRGTECENCPLIVKHGKKECCVCGGCGDGTDAAYARGSSMDSQEEEAGPEHFILQRQVATPSYVSSAQSVASNPVFMQSMRTDFEARRQAVSEEMNKKMTEGWTILDSSCPACVMPLMTDEKGLQDVCVFCDMHGVPMNERNASCLSSQPIFMPPVQSITTPTSRYTADPPANVPSYDESEAEMTISIPKNFDFNDQSAIINLINQATRKNQRVCSDPMPGKQSHVSNDEIIDLSSYPSLDEQDERSDMIAMMYMESSYGAKYQSGKGPIDMDELIDSVEIYVKTNFGPALEDMTPDIARAVWKKIRSLPASHVAEAYTIRTPRSEGPPKPESRPGTPRRSRPNTPKDGDVFDFNEPADDFSISDKSTKKLEEILSKIEHCKEALRDEAISVEEQMEAANLIEHLSKAALAVQGFEADDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWX0</accession>
    <name>A0AAD2FWX0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001887">
        <property type="protein sequence ID" value="CAJ1955440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="259" mass="30244" checksum="FD31D3508E48B5EF" modified="2024-05-29" version="1">MKVIINGTSFDQNPKHDAPIPLYKDLSKWDPEAETKIKQKIRRNPQYASPTYKKEITPWDGDTVEDYCQFRFTWNELEIGQALNAAAKHQTILSVLSGQAKENWQTVISQLPANQQTTQQGFDTAMESFALCYCTLDARQKQRRFINKALRLPKNMSIRVFWNRLLFIFRCYPHLPGTGTTPTPEHRREILIQCLPRSVENDMTRGDYRWDDPNKTDIDLINYLTRLQTIDFSETRSIPPKTTVSYKEKEGTSRLQKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXE0</accession>
    <name>A0AAD2FXE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS16095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1956143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="134" mass="15150" checksum="81F40559C56B9720" modified="2024-05-29" version="1">MVAAFHNFDGHPLGNDENVFNAALASPRVLLEHTIGILKGRFPWLQSIKNKITDDVNSRRRVISMIGVCIILHNFLIEETTPDDFMFEDDDKSTLTSQEPLAPDDKVNQPVPDWATGDTCRTQLKNYILELRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXG9</accession>
    <name>A0AAD2FXG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FH2_Formin"/>
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        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019309">
        <property type="entry name" value="WASHC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10152">
        <property type="entry name" value="CCDC53"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="1440"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
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            <begin position="686"/>
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        </location>
    </feature>
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            <begin position="776"/>
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    </feature>
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            <begin position="1180"/>
            <end position="1200"/>
        </location>
    </feature>
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            <begin position="1243"/>
            <end position="1264"/>
        </location>
    </feature>
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    </feature>
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            <begin position="2048"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
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            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="952"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1005"/>
        </location>
    </feature>
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        <location>
            <begin position="1243"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1769"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1892"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1915"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2051"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2099"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2178" mass="238010" checksum="E66EDEF5C85A54CC" modified="2024-05-29" version="1">MASRGRPYTGPIVSQSSSQGEIQLSDRQMQLLEARRRAKETGLQSSQQLKSSNYYGGAKRDPTPRMNHNPHSWSDEQTVPTTWSDSSSSANSAVSKSHSAASASMSQASASLRANHANPANPAVQFYGQGLSGQAKRLYDDSGESYHGSRSEAASSSSGSTAQSSQQEPAMVPRRVNRPKKAKGKGADLTSLATDDKQKALLRKMMKSYTGTSNPSKSKDDSSVEFSVDEAKKKRNWAKPKAASSASSGSSSTSHDRAIMRKVLERARNKKLALSNPRKHGLLKQSSSRMKKMMSPKHEKSSPREKCIGSPRSDTSSRSGSTHSFSKFGFGNVLKKKSSRSPRFSSRNAKARFHNKPDSIISPRKSLDKDLEDSKTYSHSSPSRKMLFDDSGASVPRNESESNCALADAGSADMSVQSKPENIDIRRQTTEVSVLSGRHSHDSAESGKLAQARSGIGSIPEVTTEDEIEIKLSSSTGSEISAVFPSQQGETMYDDTAYDAPEIFNPEPEGYRDFIHTLKGEVAGSHTQLWESFHSIFKGNRKTRPLQQGNGSKAFDDTTKLAVASMSTYLKNEYGAESEAGTQLANDKAVKSATSSFGQHVLNRSGVGRYGALCVAPTVDEEPDTSNFDDALSHNVHASLGEKSSQALMMTDSESEVSSYAASSDAGISYVESDYISEAGSILSSTFSRRPPKVPVAALSNNSDQTKKQARISPKSVAEKTVSKSNPDAINISTPEAPKSVEAKDVAPQLPQGNMTQMFPRDDPVASAVSRAAKIVPRKSIETKNSTPKSDALASSKSESNTIPSWKAQAIANAKKAKSDPLMESDSETGASWVGVKLRSMTPTTTKTDSKNGQMGTARTTVTSKGAVTPASSTASSIPSSWAKVKLRKVVAKAEEEPKKSTEESKSGEVQNKQIQNNDDIHHFVVRKPKTPRKPKTPSASTIEENMEAEEFPQKEASPVKKAENLSTQSDKPAAVKKSNAEDSDNKEIVSSGSTDSSSHGTVSVPLAPGPESKSFFGLKVVVGEKGIMKIDCPPNQPKPTIIWHLEITDLKSAMLDMSGYKVKLLQTNGEHKDLCFESSEHCMKFANAFHEVANDGDDGSDDEDSVAESDGSVFVEQLSEEEQKVLEEFRKKKRLSSNLSEFKPAGAPTEASIEPVVPALPKPAAGGMSFLDQIKARSTDESDISGDNQEAISSEEPVKKLTSEEQKIVDSYKKMLKLKIPMEAVKHKMEKDQVDPKLMSSVLDENETSSSSSSTNVSSSDGLTAAEQAVAATYQRMLKMMVPAEGVRHKMEKDGVDPKIIIAVIGGGEEKSSPTTTVSKPVNPASQLSAKDEATAAPYRKMLKLMMPKEAVEHKLRKDGVPINIMASVLGVDVNTFGGGKKAAAKLTDEEESIASSFRKMLTLKISKDAIRRKMQTEGISEKIMVAVLGESFVKGATRGQKTPERRMKGGFHWSPLTSGDSLRKSVWNKATLTEYAESDVASDISKHLEMFQKKEDKNAATKKIVKKDGTETKTMAKLIDLNRANNVAITLKAFNDVSQQELAKIIEFVDPHGKITGDRALFMRDLLPASAEIKVIQNYNGEDNRLVPAEIWFRQIAHIKRIEEKIQVMRTMESFKLEILALAESFQMLIDVCNQIMNSDKLPDILEMVRQIGNRMNEGRGEEAAGFKLDFLSRLSQTKGSDKKTTALDLVVMIFQARNQRSALRLSSDFPKCQEASKLQISELNADVRRLGGALQKCKKEKELMKKDANIPKWGKLPSNDTKSESSEWMANRTSFLSSVIGGGKPVEERRPVTKTETVTPSLPHDKEIESQDGSTSDDGYTMVSAVNKIEDFLTEATSGFDQLKKVNEEAVKTCKELSDFFCEKGGEAATSNLLGVLATFAENLEQAVRKQEEQEKRRDARLKNAQFKKLHTSSTTSPKQEQHNTRSPTNSAVSNASIITNHSGASEDSIGGKSLVLMVNQMLKMVGDKAKEDYAKGISYDNPDSRLKQIYERESRRDIVGKIESRRETSEHAAQTGLSELVKSIESRSARKSTKIADATALVRKIRHSSESDSSRRASRESIGSVSSYESRDDPGVRRTNVANRWTQKIDEDQVSDSGGSATLSSFSATSSEMRMQSRQRQQVINRWASKHDIVEASSKDLDEESDVGLNNTALTKTRQRYLDRWASKQREEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXP6</accession>
    <name>A0AAD2FXP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001910">
        <property type="protein sequence ID" value="CAJ1956249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="372" mass="42650" checksum="E23A45961A219D98" modified="2024-05-29" version="1">MACDGLIALDKSFSEFHLSLSGAQFDLASTIRALLCHLPLQVHRRHVKGHLDKHRPFSQLDWWEQRNVEVDSKAQSYRRLLESTGRLAASNPRFFHEPVSLFIDGVKSSKLDQAHIMEQVSLPALRAYWSSKDRLSKQSIREVDWLSLARAMKALPANLQRWTPKHISGMTGVGKCLAIWNRSAKSSCPRCSSCPVEDHLHVPHCSAPTAAAEWSKRHLAFWTWMQTQQTAPEIEAFLFEYLKTVRQPSLGVPTVRAWSCHPHLFQRAISSQATLGAQGLLEGLVSPNWRHLQALHFSYIGSKKSVNLWASRLIQQLIRMGHYMWKDRNRLAHSEDSSWYTARKREIDIGIREQFAMGLMDTPPHSQYLFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXX3</accession>
    <name>A0AAD2FXX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hemolysin III</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS15420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF3">
        <property type="entry name" value="LD03007P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1954828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32756" checksum="025833B7C4D74269" modified="2024-05-29" version="1">MHSMNIATSDMNTPLHQTNDNNNGSHKGEEDNAYYDSIEDPQDEPESSSCWWRFTNIGDEKGRQLSRDGSVHVTDEVFNSVSHLAALFLSILGSILLIVEASAQGAPWKIVSFSIYGLSLCNLFASSTVHHSITTTPEWEEFFQTLDYLAIFPLIAGTFTPLCLVVLKNTTIGWTFFGTVWALSILSMILLVYHFAKIPKWLTMTLYITLGWMGVFLSYFMAPILGWKGLFWMIFGGVWFTVGGAIYTLELPNPIPGKFGFHEIWHLFVILGASSHWFLMYEHVLYFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY32</accession>
    <name>A0AAD2FY32_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS16422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY32"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="46"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="221"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="412"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="758"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="758"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1956837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="823" mass="91747" checksum="70A4A624C27AF0C3" modified="2024-05-29" version="1">MSEAPSSFLSAAPSLFLSTEPPSEAPSTAPSFEGEVESTIVGWSGITATLIAALAQTTAFYIFFMFQRSREKAKSSYSLYEPRQFNFSHRSPSPFADNWMLEAWKVDKETLRRSVGLDSYMYLRFLRLGARISGMGVLASIILLPVYATGLERGDDTVQFNQLTLARVLQGSDRIWGTVLLWWIFIAFILNEFWKEWMEYQDNRRDFLAKGDPDGSLDMRYALLVEELPASKQSDEALAAHFEAIFPNKVRQATVLRELTPLEQKIAERQVAIENVEKAEAFIMARPEKPRPTMKINSKVPCMGETVDKIDHNVAEYERLNKEIDQMRKSSEIVDDAILLENAVERSGSEGQGLFKASTTGVITFTSLSAKESAMAGHYKGLKVFAVADPEHSILWQNATVPYSKQRIFELVASALWTVGILFWAVPVTLVVAIANLDSIFKTLGLRSIDSTSAAYGIIAGLLPVIALAVLMAVLYMSIVAAGQKFIKFKSAPEVDAYTFHWHMLFQFANLWLILIGGSFFNQVDAILADPTSIVGIIAGALPGASVFFANMLIVKGIGNFGLELSMLPAYGLTFVMSLLAPESQRTQRMLDASKTPPEIKWGQKLPDSIFVFLVMILYMPIVPLMELFAFIYFGGMYIVWTHQCLHVYAQASDGGGVTTWQTLFGFLIVCLYMGEAVFIVYMGLKEAPGPAACGFVPLVVTIIFHKYINQKIVYNIGNLALDVAAEIDKDNGELERLNGTSIEDKVFGQPALKLANEEREPMPYRRSEVATDPFRDPNRGTEDDGKQPNYDEHDDPIHVVGVYEPNHDELYKDAQESDHFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY33</accession>
    <name>A0AAD2FY33_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001909">
        <property type="protein sequence ID" value="CAJ1956242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="142" mass="16392" checksum="090EBE6EC053B6B0" modified="2024-05-29" version="1">MDPKVNDEFAEWLNMRYGSIQACKIVRGKIHRYLGMTLDFSVKGKLKIRMDDYVKNMLEDFPVKFNKDSKQETPVGNNLLEAGKGKLLNAEYRQIFHTTVARGLYINICYFFITDQVEKGNVKIKYCPTDDMIADFMTSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY62</accession>
    <name>A0AAD2FY62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="96030" checksum="6AB1EB8963EFEBC1" modified="2024-05-29" version="1">MASPIPPFATRDGELLFNPEEFRTGDKSKYFNRPILCSQCEDKAQQATAREVQTPNGLLHKSEANNGNDVVISVMPVSYMINRDQKRFISSLRQTGYNGHIILGVQPNLPAMNMRFLKSHNVTIYTVTLSPCSPPISGFKTLKAKTPKCFKGLENLPFEWGKYELARQWLHSCNECTGRALLALDGVSTFFQTNPFERFSNRKEDLLFSEELAAHTNPFYYDPDKLDVRHGSLFSSNYGSMFKRCYPKFSAEGIGNNRPILVPTTVLGSDEGIARYLSVMSQEFENKIEGTSCHYPTISEVGVMNYLYYTGAFGSSISCATLPWGTGFVQDLEKPCRNQYLQSGTSKSQLDIVRFDFIETGFIANRYEISVDGAYQPAPMLHNYDNCDKWVKAYLKIHGELTGQIMEKPPDYLEILEHTILNSVVDRSDIAGGEELNPMKTSYQRSTVVQQAPWFPAEKKCKISCCAQAIAIALEPDKDHLITSVDGLDLGDVSVLGHGRKGFLQWAISDLNYDIIPCLQKGTIVYADHEGGGAKRFFDIYRPRMTEPYLLVTGGSDGIEPLKPKGQGREILQTDDLLIGWYGINPCYECGADHPKFHMMHLGLSALYDHQKFLAARLNERGFGNPFSDVKKRRWTQSTELAVATGATRLVFVKFGINAHSQHRRKPFEMACKNRTGTPMDEISCSMGLKKFHNTEIYDAAEKYLFGLSPPGNGLDCYRTYELYFLGVIPIVLYRKENEELFRGLPVLQLENWDLTQEGLVGRMREYIESSEFQDTRFDGWERLFLQYWRMRVLNETGRLDDIVLDDVGKQYYKSWTYTRYVEPYTKTYWPPKEPLEKIKDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZL5</accession>
    <name>A0AAD2FZL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="311" mass="34839" checksum="132882A3580A4524" modified="2024-05-29" version="1">MITLTTTTTTTNTSPKKPDQSSSSGFGFWSLNNTSSLQSSTFSYSSPNKKKNGPLATTTVSPILTKDPTISTVVAKQSPPSPQPQPKKKKKVNFQLQCQVRTFEVVALDEDFENNCEDDEEYWEQMGEDFWYQAYDFQAFKKDRRSLVDRIRTIGVKNAKGNYAMEGLEFFLTLKAREVHKERVLDGWVSVLELQAEWEKDQSEGDCSEDDKVELIASKYAHVSKACLEDANKRAIETAQEIQAEDEKIVASIPKSPQPKKGSLQKDGKGVKALGVWGNTWSSTGTSTISNNTTTTTSFSTFQKIRPFPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZT6</accession>
    <name>A0AAD2FZT6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS16952</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12974">
        <property type="entry name" value="Phosphonate-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041972632" description="guanylate cyclase" evidence="14">
        <location>
            <begin position="28"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="11">
        <location>
            <begin position="560"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="670"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="16">
        <location>
            <begin position="1105"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="706"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1336"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1340"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1957939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1375" mass="153042" checksum="682A6BD71DE0CA1D" modified="2024-05-29" version="1">MMKQTIRWAPIAYTLMMLMAAISQAVALDNDTTAPIVPINGTTNAPLEGNIPDVGISDPEKQWPTGQLDCAQGYRQFNELTQKKVYHIGIYAPDDIETTVQAFNLTFETYLTEAVGKRWDPPIEFKMVPTRYPLIAWIDQEQDVDMMYADSGFFSCTGTEIGAQPLGTTLSRTKVRGRYYDLDVLGGTMLVAADNRQINNIADLKNKRLAAVKISEFAGGQSQFWVMMKNGLDYIMDPDQVTFTDNQEDVVRGVLDGSWDVGFVRTGVVEQTTDLETGELLDPELFKVVSPRIYIMDDGDLFPYLHSTPVVPEWPLFAKQDLDRVIAEEVSAALINFHYHNNVGRAIHECLDAAKTAAETDVCNTMSPSDFVKEARCDTTREMAELTYQAGLAGRHSGFRSARSHFELRTIVQDIGFVEQNKNGDWQCPRVTTLYDAIKCPEGHYKVLEDQFDTQCALKGLSCPKEKGYSCYCKPCIKAFEVDLFQLDEEKEAMTDAALSNLGGCDKMSLCGEVEQGKKLKFHIQDNLDRANATVTALVHFGQETRALTVTKTPDELHAYNFFFSQNQRGVAILEISVDGVQVPESPWRVEVIEKVCFENQMVANENGVCVCSNNSKLIDGKCMADGTFAGIIAGACGLILLLLLWRFMNYRREKSDEVWKVNVDELHFSHPAEVVGQGAFGVVLLAEYRGTNVAIKRVLPIKKGGSTKMSGSRIAGRSNEVVEDSADSKSRETAEEQESYDANHSKDLEAPLESFGVKRGSLATSTTGTGDNSKLGFLVGLGQRHRKQSTISRMLFGSQDTSAYNMNVLGTASAGSSSHRGIVSKVFPWCDATTQRQTEFKEEMRLLSRLRHPCITTVMGAVMNGYEPMMVMEYMENGSLYDLLRNETLYTGGEIILQIVRDVAQGLRFLHASRPPILHGDLKAKNILIDSRFRAKVGDFGLALKNNRGLSGTPFWLAPEYILRKTDYNSHCDIYSFGIILYEIYSRNNPYSGENPRSVLRKVCDPRINHRPAVPSTCPKRMSEIMKKCWSSDPLFRPDAKDLDMIFGEMTANDTEPLADASPTTRVRTQVATGDMLYKVFPKAVADKLKAGQKVEPETHNNVTIFFSDIVRFTDISRALTPVKVCGMLDRLYLAFDALATKHDVFKVETIGDAWMGVTNLENDQNETHAKRIAEFAIDAVQAASKVMIDEDDPEAGYVHIRVGFHSGPVVSNVIGSLNPRYGLFGDTVNTASRMESLSVSDRIQCSEPAAKILQEQAPDMPLRKRGKVAVKGKGNMVTYWVGESAPVRTAPKFNTQPMVNFAGDIVAPPPMPVENQVSRSAMKPVQKHGIKAMFRSSRQYDSKEEIEPHSESPVEESPHPEYHAIRIGRSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2H3</accession>
    <name>A0AAD2G2H3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001998">
        <property type="protein sequence ID" value="CAJ1959445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2H3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="138" mass="14545" checksum="B514AB3AD1D95BAC" modified="2024-05-29" version="1" fragment="single">SQPPAQNNEVSPDRSEFTTPPKKRKSKDTSTTKRSVDRSKAGLKPPTMSTRTSTSVHFQQPKQRSRNMSQVQVDTTQMEGDTTTAVSQDESLSSLTVASPGGVHPFFLPSPSGKSGTSGSAKLPSSAGRGAPRFAAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2K8</accession>
    <name>A0AAD2G2K8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2K8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042262439" evidence="1">
        <location>
            <begin position="24"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="318" mass="35747" checksum="2EE745FE315171AD" modified="2024-05-29" version="1">MPSSTQKVWCLLSALSFLSLVHSSGDSLNVDLEVVTNVDLRNLGVEGLDIHAGKYSLTVDASCQYTLQVDFKEHSSDSLVDVPNRHNFQGDCDKVLGTFLHQHNRNWMQFKQYVQDTTGFDHMSLYPRPCGMEPLGRRQPRYDVNFYTADSHHRAMWVCRTFDRPEQCEFNQPNFLGRGHFTIPRLAQDPDIIANTPANFTYDPDRPQALEFEGLIVTNSLTVPETPTDMKTPEIEMSTYDGDTVSFRVVVPYKLVTGDTSGSYSGTVQYEYQNMMQLPGSWSVNYNAPSSLISVVVKGKGKLCGAEFDEAKQAQESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G300</accession>
    <name>A0AAD2G300_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G300"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="829" mass="92789" checksum="902B109EB41A6637" modified="2024-05-29" version="1">MMNVETVLSASTESDVGGSNVRLFSPRPPSFRKPPPPAAARKRLSQDPPGDTITPVEAAILELVPQDVVAMMEDSVDHESTQSTLTGPPTINFANQPTDDDWEQEHPGPYNRRSQHSRKSNPSRSSKNNKANKKNKQMSPAATKPRPSPAKARKYDSDESSSLPEVAQKDDDHDTDEEDILNFLNRTYNPEHDDTARDESLLFSDHVDEEGEPRESYAQQSAFLNPDVPKANRNLRTSLDEGVHKSQPPPPPPNREEMQRVPSKQSMDSTIDTTQRTAPKNRRQRPSSIPQFKQEDDVDSDLTPVMKSPHHTKKPSLLQAKQQNKSRGNTQKASDLKSPPFQASPVAKTKPSASSKKQKPPPSKSKRPTRPGKRKEATSKDNNVAAATPSKSKRSERPAKKEQAKPAVSSRDDSQDTADAVKKKKSYNRQKKAPPPPPSPKIKSPTSVLDDPNLTQKAPKTSTMQRAINDPYLSDADSSFSSYKFFGKTTRPANQQQQQQQQQQQQQQRKQDRNALLGLDDASSTSSSFLYGNGNNMGPSRTVPSPGQNSSSKRSRPDHPNDRNALLGLDDDDDDASSKSSSLYNNARRPTRIFGSRDEEDRHSQLLGYDDFDDEGDGDSSLEDFLRQPQQPAQARNMNRGAPQHHQQQQQPLNSFSQIPIHPDMTPEEWQIAQEQIRFLEGELDKVSALCQELTEAVEKEEEEEGDGARGGGGEGGDQPPNGDWARAQQQVKYLEQELETVQELCNLLTNTAAESTDAIEMLEAEKQRLQDLIARLEKALNKSKFRMDKQQKALEELVQENDSKCCSWCWDWISEPVVWFVSYLYRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G414</accession>
    <name>A0AAD2G414_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine protease</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS12800</name>
        <name evidence="11" type="ORF">CYCCA115_LOCUS17712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001989">
        <property type="protein sequence ID" value="CAJ1959291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G414"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234:SF5">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042440674" description="Serine protease" evidence="9">
        <location>
            <begin position="16"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1950872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1959291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="304" mass="32641" checksum="1B10431AAEBA63C7" modified="2024-05-29" version="1">MKITLLLFTILGVTAGHNERESKIRPAVKTPSGGHNNPRESEKARPAIGEKSVHSSRSDNNDLDVLVDGKTLCGHMDLRNARCYENSLPAIYEKAMAVAKIRTGGLVCTGWLVGGNNYLMTNHHCISSKEEAAAAQFLFMYESTQGDCQQGGVRDTDAAAEMTIDGAEFIMADKQLDFALVKLVSGNPVCAYGHFDIDWEAPKVGDEIYVPQHPAGRDKSIGITDTFTESGMCEIKSVSGIGVDYTCDTEGGSSGSPVVNKATNMVVALHKAGRKKCHGNTGTKMSKIYGLVQEEVYGAIAECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4D9</accession>
    <name>A0AAD2G4D9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4D9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40196" checksum="680B9F82F3DBF243" modified="2024-05-29" version="1">MSSLAATQADGYYLPPEYYDSGTYKKKSKNQFANSKGHNQFVKSGVARFELPYKGVCLSCKTSIARGTRYNAKKVDTGESYFTTNIWEFQMTCRVCSHPFRIRTNPQERGFDYVEGIKIQAGQEPSKELLERTFSTNMDVPDALEKLEAQAKGKKKLMTEIDQLEGLQKLNEKTKLNDSASNATIRARFRKDRKAKRARIREAKSLGWREGMEVVGTSLDDQVAAKETVFGRSKETEKKRFGAVKQSSIFGNKDESKRKRTGRPKREKDEDIPNAATIFPDPAVSKTAIPLDLPSNPIDSEVKPETDLRKQTRIKRKINPAMIQQNPVDVLKSSSSSPVESTFSSMLAGYGSDSSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G605</accession>
    <name>A0AAD2G605_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS20579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G605"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF18">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1964331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="341" mass="36523" checksum="7DA5B76A036A3ABA" modified="2024-05-29" version="1">MKLKVKTSDVEGGDPKLSPSPTTASKGLPDNVKLLIGAGGIYASFLYYGSLQEDVFNYEAQDGVRFTQAWFLQVLEALANLFVGFIGMRLAGQTTGIPIKMFGISGVTQVSSKAFTSMALANGLSFPVATLAKSGKMAPVMIGQLLLGGSTYSVRQYLQVAAIILGTAIVSMGKKKAPTAASSFLGVVYIIIALVMDGLTAGYQKKLKTETEKIGIHPKPYDFMFWTNLSMCLTAVLITIILGEFRTGIDFLMANPVILSKIIKFSTCSAVGQSFIFYTIAHFDPLVVTTITTTRKILSVLLSIFLKGHSLSLTGWSGLGLAFGGIISELKSKSSKKKNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G655</accession>
    <name>A0AAD2G655_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS20454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G655"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="57"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1964064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="253" mass="28119" checksum="87DFB754DEF4F959" modified="2024-05-29" version="1">MPNLPITSDCSLKTEQDAALCASSSVSNEANEANEAKSTPSDRDGSVRVHSGSGFRFVVPFPWRLHQILDDMDAAGDTSIISWVPDGRHFHVHNPTLFVQEIIPKFFKQKSFKSFQRQLHIYGFQRAADFPNQGAYYHDKFVRGNRKLALEITRIKAPPRRRMTAKAAAAALEEKKLHAVAAGIAKEMSMPFARREIQLPAPRPLSSDTTEWLISAGVPFAALDPYPFHRGKDLSPDASILECASEIASIFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6F4</accession>
    <name>A0AAD2G6F4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6F4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="562" mass="63529" checksum="56D69999F657493A" modified="2024-05-29" version="1">MTACLDFDPNSVFVFTAATTKDQVPRNVRFVLVDGSVRVLPDDIFRDCESLEEVTFEECTHTIGKSAFLACVSLSKVKLPSTLREILESAFECCYNLTSIDLPVGLKVIEESVFEESGLRHLKVPATVEIIEYRAFHYCKHLVSIVLPPSLEVIESDLFSLCFRLEDIEIPRTIKAIGDQAFEDCSSLKELDLEHCIECLTIGHRAFYSCSKPEWINLPPNLEGSIEGGTFAKCSALTHIRVSQNITSIGRRGESNPFRRCKSLLSLELPEGLETIELLAWDDASEVWKYAFEWASLVNVYLPPSQTLLDVRILSNEPIPEDWQLAKVAQTWGDLVPMLQRRFDGLPLHRVCYFHSYHPVEDTAEKIRNILKLTPSAVNEVDAFGMTPLHILSLAQKPVVELLQELPIVFAEVALSSKDFFGSTPLDYVCKNPLPEGMNASRWMIRKILEGKLPFLGLRRWKQELLVAEERRLTTADTSSMRAGVKSLLGKLAHLEFLEILSLVEMVLWQIKLNENVMVETGDDKPRSDRESCRVQCGISIVIGNILPFLREREVIAQAEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7L4</accession>
    <name>A0AAD2G7L4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS21278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7L4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02910">
        <property type="entry name" value="cupin_Yhhw_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212:SF3">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Quercetin 2,3-dioxygenase C-terminal cupin" evidence="4">
        <location>
            <begin position="184"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1965685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31538" checksum="1AB0C304F7993B15" modified="2024-05-29" version="1">MTAPTSTDTRNNVKVVPNDKLYVSEPNPMWFGNRSNPTDDPSWTNKNWLKSRFHFSFAEYRNPKNSSYGVLRVLNDDLVQPMRGFGAHPHANMEIVTYIVNGKLTHEDSMGTSQSLGRGSIQFMTAGSGITHSEHNHTDKPLRFIQTWIVPERRGLSPNYGGYDASDKLVKNQVRHLASSIKDNANDTPVKLNQDVNCRAGELELGKSVSVDLPEGRQAYLLCVEGSLKVNGQALARHDACEITSDGEAIVIEAVGVEDTENGEVGHFLMFDMEEVEGSGRRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G966</accession>
    <name>A0AAD2G966_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transaldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G966"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF40">
        <property type="entry name" value="FRUCTOSE-6-PHOSPHATE ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041944714" description="Transaldolase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27021" checksum="1A2DD55402FC59D7" modified="2024-05-29" version="1">MTMLKLAMLLLLSASTIISTKAFSPLFRGEARLFLDTADTTIWQELLPTGIFHGVTTNPTLLERAGEPCTVKNLHKMAKLVLEHTDEFMCQAWGSTADELYECGMALSQPSRDRIVIKVPVTQIGVEAASKLIQANCRVCLTACYNHKQAMIACSVGAEYLAPYLGRMTDAGLDGSAECLKMQAITEGMKSDTRILVASIRNAQIMVDLAASGMETFTFSPEVARELFVEPLTTEAAAVFEEAAANGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9H5</accession>
    <name>A0AAD2G9H5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9H5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042148524" evidence="3">
        <location>
            <begin position="18"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1964931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="335" mass="36836" checksum="CBA29D145BDFCE74" modified="2024-05-29" version="1">MKLSFAFLTLFAASASARSLSPQAAAKVLRAARRLDQGGEGENNGENNNGENNNNNNNNNGNNNNNEEDEYAFLTKYNLKFVGCDASQQMLNDEGGYSYGAAFLRLCPSDSGCDSSTVGGCKEGYGDFAVAIEDFVDAYFEDQQDNMQWDDNFDGDKYAKCEQYEPEVEGDDNPYENYEFFIGAACTEDGEDIRLGFFSDDTCQTESSVSFGDVSNGWTLPYSSGGLVSKYCSDCLEYNEDEAAYGLRDMCTELYQNAPMKCEAKMEYFSYYGQDTSSCEAIDEILPRAARVGGGGAGKFFGWLLFVLLIVGVVGYVMWWRKKKQASGAADGMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9Y0</accession>
    <name>A0AAD2G9Y0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9Y0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF14">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="306" mass="34859" checksum="542A5106C4856D63" modified="2024-05-29" version="1">MTEIECPSGSNFPPAMSDESEKIGTETADQADKPSHSTDLVYNSKKPRWWKSVAGNATKGQKRAMETILANHRLPSVPYGTFLDWSQIFPENPDIWLEIGFGQGENLLALAHRKRHENVVFVGAEIHKSGTGTACRRMQEGKEINRFWIDYTVFSKDSTTSNNPNEEGSDGTEKHDDPYRNLRLHPGDGVKLLPYIPSSSLSAVLITFPDPFPKECQRQWRVIQKHTICEIYRVLKDSGHFFLATDHDGFNQWAHLILNEVNEDSPIFLEVNPCPGRMDWLPVVSKYEKKGWDEGRSTNLNCWEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB64</accession>
    <name>A0AAD2GB64_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002383">
        <property type="protein sequence ID" value="CAJ1968455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="120" mass="13486" checksum="A09309B236F87F8C" modified="2024-05-29" version="1">MARKGKGFHLAVAYNTHQPQAAHSTTQFGGCSTSAFNKVSHRVRSSGDDSSGRWAWNRLQGRTQGVGQRNLVVISAYRPNPPNDRHQTMWFQHKAHFSHTNRDAEPREAFIKDLSTAINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB84</accession>
    <name>A0AAD2GB84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002369">
        <property type="protein sequence ID" value="CAJ1968183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10288" checksum="42161ABE9F58F6EE" modified="2024-05-29" version="1">MKAEGDSEKAIQLFQEALDNYKDLSSISPNAAAVYENLSALKVDQGLLEDAIAASAGDLKIRRRRFGDQHADTKLRMTTHRSLLRRLLESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBH2</accession>
    <name>A0AAD2GBH2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002288">
        <property type="protein sequence ID" value="CAJ1966438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBH2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="100" mass="10912" checksum="4A7172161075215E" modified="2024-05-29" version="1">MDWRKVKAMVQSDMTLQRNLQEKNVSRLPQGGGRSLWWVTATNSSPPENQSSDPMAVRVGDVAHWRQAGLGIKWSATSPSVGGLGERTVAIDMVSGSTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ31</accession>
    <name>A0AAD2JJ31_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="3">
        <location>
            <begin position="1800"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="1976"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1654"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1714"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1853"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1655"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1739"/>
            <end position="1757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2797" mass="307376" checksum="80C8B3D3A076EE3E" modified="2024-05-29" version="1">MSTSNTSNAAMDDFQEVSMSQHLFEQVSCWTNPDITADKKVEKANHLKQYVQEVDGYLNISSDHPCEGQWPVLEWNEHFRKAYTILLWVRPVVGPVLSKGDQDGETIIDRTDDSHIHPRVLYRFATHPGDSAAQGVCVTLGEWRCINVDTTTANCAEPSSKRRVMTHLTAYSLPSVVPGSVDETDADMMGSSIVMAPLELWDNEWSLIGITHVFPYLKRPHWTLCVNGRVCGSGELTYPILERTPVMNFNTLLKDICHGGVEYIEDKKSDAQKTASELQNQVFPKHKLEFHLASYCLACDSFGPTIQAILAQGGPTMSIMNGGHIPQLPPLANWTKGSSLDGPNVGIPLVVHGQAITVQQLSASCMLWGSAIDARILGRQSKNRGQRTACRMTFRRGTTHSAPRVGLIQPTPPNPNGPRSVTEVGADEDPISLTLLGICTIHHNLSDYLLKSPDATNVDTQMFNCTKHFSLLLEGQALDCQLILPFFLALPPPGTAMELQFELLTNSLRHLFDLYTNEAELACRLIDLLAASVKSGGGRWEEQLLQNGSLHVMACALRQSLVRAEYLQVDQFDTYSDFVKAHAQNTKMKTIMSSMPVSPSIIPIGVAKSMANLIASCCGPQANFLEDLDPSDQIRRTSDLALTALFGIGLDWELWGRDLEAATVILEAVASRYGGSCVTAGYIMRSQVSVQFFLDTLKYPLQSKRANLSTEKADKNALERIGNACGKLLKAMLLSSLSNQRIISQGEHDISACMGALSDCPLGSVGAHVIFTALMGVLQWCEIVPEDENMPRSRTVDDDHKCEVASRLGRNLIMSEFHDVVAPMLLSRTVFCGERTMSLEQSNLPLSWDLHWRYGLVIFAWVSTIAGPEGVIASKSLGSLLLASSLAGSLKGALANADKDLVTNLLMPPPAMALTVAAMTRRNEWSYTDLLADRLQIMMPMLPGLVVSIVSHPSDVVKDEALLDIEPNALDVLAEIITAVGGSFYRVFGGMTHQAVGGSRNKKQSRLVDSTAVQAAKHYIPHLITVAVILENHILLRDDSEDEHVIILKVPAMVQRQADDGSWVEVSSTMMDGILSEGGVQVPEGGSTLEYLKACQKSALTAVSELMSNAMRSGGGEASTMLWRSALMTLEDSRSYAADSVDFKDRRALDKTAHNILCRLCAMVLVKCLKRDYQWEVWSSSLSSAVSRLCMLIEERELLLTPMGNEKIYTKDQVLLLCALLNILTYGRDTTGWCQLILPTPPLEAGTQGKNPEIELRDRGDSAPAASKLLLPVLQPALRSILGSIGVQKSEVQINIPKASKPKTQSSGKHVSVYEVENVVKLLDHIVSELKETLTAAIVGMSFANSRDVGLYALATLRRAMGNYKNANDDYGLEVCNTLFGTIAEEMRVRYEGERRRRETALFDAYDDDDEARVDAAAGSQTVERMMLGGAIAKIKGTVEEVDFLSSEEKRRTEDDFVLFDDSFGAAKETHYLPRMKWKHYEGLGDALEESLPEPSKKKEDVGKDVPIGPVLTAMTPFLDSWDEFAAVEAAESELVKLFDFSLDSAGGMNREDEREMQYRLQATETAADSMSTFIELAAAEKSRLAEVTTSFLPNHRSSTSSYAERFCWARYLEIAQSDMMNEIWERGVADGNRDVRSRLVTIPCNPQFRRHIPKYLDHSTDSRDNSSAGQGDDELQEIDAFTKTLLNSGHLQIVDITKKEVNEDEQPELIFQSGNLDDDFGERPMEAPTAPSDKSDANSDATSTADATATTDSSATNEEEQVPFDKSKIGSSHYNITASAFASPPDNSSSTLSLMHSAAAGLIEKHLENCLHVKAEGSRKCSLLLTATHLILEYDIDSDGLFEGEMMAVREEAERQRMSEDPKKNDPNSEERIQQQIERRQREAASLRPKSIRWNLSELSHVYLRRYRLRDSSIEMFFIPSGGTSFGGYGLFSPSTSLFIDFGPGYEGVTRRDDAAFAIMRRAPPQAIKQWPDRSAQFLHEQLSRLTMGWVEGRITNFDYLLHLNMLAGRSYNDICQYPVMPWVLSNYSSEEIPDLCDPANFRDMKKPMGALNPDRLQDFIDRFNTFADPSIPPFMYGSHYSTMAGVVLHFLVRMHPYASLHRQLQGGNFDVADRLFSSVPRTWEMCTGTSAAEVKELTPEWYCSPGFLKNGNKFKLGTSQDGEVLGDVVLPPWAKGSPETFIEVMRNALESDICSQMLPDWIDLIFGRKQQGPEAIAAHNVFFYLTYYGSVDVAAIEDEGLRQATELQIAHFGQCPMQLFVRPHVRRIQNYNKRVSFYQITSAYTHGANRQAGEEQKHNDSSDKGMNQVFGQPLYLPFFSAPMSHWVHLDAPPPGPHAPLISVRLAGTDRCLAVDAQGVFHCFRWAWKAEATTEVPALNGSGGFPMDNGCFIAQRELPRFRTLPRLVHRSREAEPPAVAISKTLFAGRSVLLVLSDGDGRGGLAMQLVDPAKGSVRGEAVVQAIHSAQITCIATDPIGTAAGHGGVGGELAIVGSYDGRASIWRFMSSHYLPLRPRVQMAGHGGAAIHAVGLSAAINIAATCSSNRLCLHSVGNGNLVRTIQPPQNVLDLPAETQGVTRFADCPALAISVHGFVVAVCETKTKSPASPLANRSIITLHLFSLEGVSLGTKPLESWRGRPNKMYCTPDGTAVLVCSGRGVTIHRLSAVTPLEFIDEWHITEQEELSKNLAQAYDIDLGPSLNRPVVAAAATSNGVLRLHALSGISSYSDRHKKLGVVQGVGNVLAMPAKRLKNVVGRGLGIGSKVVGVGKDVGKEVQSDIKEKGVGGFLGNMFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ44</accession>
    <name>A0AAD2JJ44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF5">
        <property type="entry name" value="FERULOYL ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041992145" description="Phospholipase/carboxylesterase/thioesterase domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="4">
        <location>
            <begin position="169"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1953898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="419" mass="45563" checksum="61B2E2BA32E3867F" modified="2024-05-29" version="1">MMMNNCTERCIIFFLWVGLVSLERCDAISEIDIQDLAKKSNARPNCDIGADSLAKYGGTRTCIESPTFEGRRCFFTIIPDCAGPDSPLVFDAHGLASCPSKTAELTRWKEMAQEHCFVLVYPLGTTDPEIADLTCWGLPGGAKDDFGDEAHSCCCSRRIRPVVTQDAAVFRQIAAVINRDVPIQTSNRVTIDAKRIYLAGHSNGCMAAISIAAQSSDIIAAVGCHAGSAITPFPGSYHATPMALVHGTNDRVVPYKGNFLFHSAETTHDIISKANECSSFKETKTEEFLGSNNTVTEFSSTGCKNNANVTLYAVEGAGHSPYLGVETFRRDEVPTNFDSTELLWNFVKNYELDTNPSLVDRTTGQSPISLPSLPDPFPELVLADEQKEQTRNGASAGHIISIFRSIIFVSVVTACHSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ53</accession>
    <name>A0AAD2JJ53_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Geranylgeranyl diphosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS15589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ53"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000001">
        <property type="entry name" value="Geranylgeranyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053378">
        <property type="entry name" value="Prenyl_diphosphate_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045485">
        <property type="entry name" value="FPPsyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43281">
        <property type="entry name" value="FARNESYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43281:SF1">
        <property type="entry name" value="FARNESYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042040689" description="Geranylgeranyl diphosphate synthase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1955111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37233" checksum="21E057BB82C9390F" modified="2024-05-29" version="1">MKVSSAGLLVILAHCASTHTSEAFSIITTSKNHATGATALRSTAEPQAKTEFNLNEYIMAMQPDITKALEETCVSLDPPMTDLISESMRYSLMAGGKRIRPVLCLAACEMFGGSKEAAIPTAAALEMIHTMSLIHDDLPSMDNDDLRRGKPTNHVVYGEDIAILAGDAMLSTSFEVVAKQTPRDLVDAERILDVIGRLGKSVGAKGLAGGQVMDLICEGKGNDVTIDDLRWIHTHKTAALLDVAVASGAILGGATPEEVKACEIFALNIGLAFQVADDILDVTQSTEELGKTAAKDLEADKTTYPKLLGLEGARAEAERLVVVAKEAMAPFGDRAVPLLALADYIIDRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK41</accession>
    <name>A0AAD2JK41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="402" mass="46425" checksum="B652CB99CD5D0232" modified="2024-05-29" version="1">MRIRVKYGSSSSRNKKRKNNDGLAKFLLPLLSIITMIAIMSSFPGSTSSFYILTDGIIANKQLNPYIRNLTLDLQSCSNGWCVDTEFRTPRYAAAGPSVAPLLLPQTVHAVPRYTHQGFEKCFANKVVVVIGDSRLRYQFLNLAAFVKYSKFMKCQDYHGGQAEVERVDESCFLIDRESSISNTEESIDWTLWYQETTLELQEGSKQQSLCDCFRHNPFAVRNVYENRYIQRSTDFGTIHLVYLQTFANLVRIDQKFPPYDSYAPRESRCKVGECGVGNRTNAFEGTVEKTLWEVVPKLNATHAFVSMGWEDNWEKISDLACVIRDFQQFYPNIRVFLTINPPIRANLTRDFDDLKCKVDIYDRDTMSKNVPTNWYWDDTHALSILNEEYNHQMMEKVCPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK80</accession>
    <name>A0AAD2JK80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2834 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK80"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14450" checksum="D6E05525B9351437" modified="2024-05-29" version="1" fragment="single">LAFGLGFGSFVHQKEPSWKIPAMVCAGFWGFTAFTVDQEGLFGFIPNHIMNYWRNQVFYDLLFSAGLFWFALAKRAKKVGMPLLPWFIYVVSVASLGGLNMYARILYLEEQQGKLDDCPVNVNSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLF3</accession>
    <name>A0AAD2JLF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-uridine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS19177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="6">
        <location>
            <begin position="187"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1961399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="433" mass="50071" checksum="3B82102BBA3CB392" modified="2024-05-29" version="1">MMPPIHHRHSVLYYGDTTATTKNEISLSAEQELLLHDLSIERCCHPFNETVQSFYRYNFHKKRNKRLVPSLPKKDEDCRNDAVYIYRTSTGMVLAALRLTRSKMDSKYSFLRSLCVSRDYRRHRIAMRLLKEALADFSPASDPSASNYCYCFANPYLEGMYKRGGFKRIRKSEMEAWPKWLIHSYNAMDEKWSRKTLGLFIKPIQKLDDDSEPGNDHQVPAIIRVVLLQHGLEFAKATATGWLLDDKLYFAKKKEEREDVLSTHVQVDRWVWNGRNDTDQIEDRLSLLQETTRPVLLWTGGSDETANSDFGFFATNGDPTTPKTYIVLDGTWQQAKTMYRKIPALWTLPRLSLRNLPPSKYILRGDFSGWKDRFGATEKWDDERSSSNSETLLCTAEVVAALLDLHGDHAGGTVVRWRLDSFQTNFLAERMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLG1</accession>
    <name>A0AAD2JLG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS19190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1961425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="403" mass="44017" checksum="28D1F1C9F5B9A7C2" modified="2024-05-29" version="1">MPTSSISSYSLGLVFILLVSLIWAAASILVQYLYANEDFDSPFLLTYIGVSLFTLLLPLQWTKERCRGPQQPLEEYQSVPSNDDDGDEEHNMDEVDDDEHDDEHDLPPSSQGKVWTTRDHMVAAAKIAPVWFISNYAYNSSLRYTSITSSTVLASTGSLFTFLFALLFKDEHFSCFKLMGVGLGMMGSIMTGLHDIHSNNGDDATNSPDTNSDDLKLFGDGLGLLSAVGYGGYAVMIRILCPKDESLMSMELFLGFVGLFNMVVLSPIAIWQSATTAVISAFVLVSLLLKGLFDNVLSDYLWARAVVLTSATVATVGLGLTIPLAFLSDVAMGKPNVLDVSSIFGAFAVLAGFILVNIGQKEVDGEDSTDDHQQDDIHQPQSMMQMNIALSEEEESHEGVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLX4</accession>
    <name>A0AAD2JLX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1962971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="477" mass="52140" checksum="BD236C1C2A4F27CF" modified="2024-05-29" version="1">MMSKKEVDITVYGATSFVAKHVIRYLVEAAAQKDHPPKSFVVALGGRSKTKLEALQKKFAAGNEAATKMFAPIVFVADGNDLEGLKKIAQKSKVVLNCAGPYSKYSSNVVAACAEHGADYVDFTGETNWVAEMRLKYSAMAKKSGARIVSLCGYDSIPSDLALFAAVQALRGKAPNAKIESGTIYHQAMGGANGGTIHTALDMPVDLKRDVFKTTTAGTKQTLRKVPFLMGDPLQLTHPQTVRHNPDFEATRNRYALSEWLNQLLNFHSEFSYGVSIPMFMSPINMKVLHASSIALKYGPNFKVRERFLPCGFVWTRVLGIMGFIPAICMQLVLFATIALLKMPYLGKAIADFLTPPGSGVPDSISALGTTAVYATVTSDVKDLSGKVDRGYAYLSFKGDAGNWTTAQCICESAFCLIFDKDSLPKRSEDGFGTPAEIFGDVLIKRFKETKVRPVDVQINVRTDVNKNEMKVYINDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMD8</accession>
    <name>A0AAD2JMD8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1233" mass="137335" checksum="18A77DF7442340AD" modified="2024-05-29" version="1">MSKRGSNNSKQRRRGSSPVSKTTPDPFVNGQIPACRELLTAIQDVFPELHTSKNGQDSSAFGKLLRWHYLEKRNAKQMPPPPPLALADRNESETSANAKKKKKRKKKKKGGAGENNGASNQQHQEALEAMAETNAASSDDNKSIDPFEAVNGKTQSRPQSRRGSGVSLDPFEALNGKTHSHPQSRRGSLATSSRRGSLNNDDNHLHDSGYFFDQIQPQNSTQELLSPTQFIKQIRPETMPGLPSLDDDDEPSSSHHQEDALFSPTQFLKQMPKETSSSPLPTLDIDSADEDDINKESTTTAAAAATNKNGDKSSPRTPRKSPGSNSAAAQGTPSQAETDKSSTLNSPNHEWVPEEKSESQQETAPGDAIKDPLTLPYLMIFSEGSGTITTKTIDGSLVSAALPTYQEPSRMETTKVLFQEWLGQLNNDDLVASEPGVANRDPKKDLASFVDFLQARTHGQPQQVGIPFEQLQSACSNIKSYTCRQTATTEVEKLRSSRTKMVVLDASCLQEETKAQTTMSVDAAFDYVALEEGHHTPLKDNTKDNDPLENVDLTKSVSFVLSPASDGSTTAPPNGNNNQYLYIRELSAQHLDTLTEEWLPCGIEEDVMVTTVIKDGGSDSGLIALSTEELEQIQKQVTVKERALKQGLAHAESSKTALYEQLENKSSFGGSSQLLNIDFNSFPQLQRCDRQCGELMDGCFEVLRVLSKENTHALADLQMQFWTTCLMALNKVLKSAKNYYEKIEHHADQNGSLPKIFVSADLRELYRELLDEKRTAWTDVCNKYERGMSKRALREYYTRTSWYEFKSQSKTKPNRLDEKCFELLDHLVNWTDTILGRRMSDIYKTRIGQTNQVLELLQKVVDPLTEQYETVERFFSSERNVYFANLRSQIVLVRSVKKQMRLLDQDEVESMVMGVLLMWRQTRIMQSRMVQSQAIPPLPLQLKKWMLQDDIDSDVWKWDSPPETSIPITRHMNYPLGAGGKRRAMCVLAGLVYQWLGDRYKEWQAEVAEQELLTDFVAETEKPAVTNGESKSAKKKKKKRKKSGAVSPSRQPLERATSTASADTESGDESFTKALDEALKGTVKEAAPEPEVIISSTAPVAVKPMNWAEIDSDEEEGFIVVGQPAEEPPVAVAEAPVEESPVEEPAVLEQTVKEAPVEEAPVEEAPMEDAPVEEPPFKEEEEEEGIPFSDIDNYQSAVRIRGRRKEMSASDFLIARMEELLAGTDDGKKVVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNJ3</accession>
    <name>A0AAD2JNJ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNJ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="56430" checksum="E0A1DA3EA2F75F0C" modified="2024-05-29" version="1">MEGRGASEEDPVASVMEETETSAGEATSGIPEEKELVPSAATETAILTSEEAEPPTPPEAPETSPAPAPAPGPAATTSPALAPSTASTAAKGAAASKTSNSLDDARRELAILVNSKKITVADCKALKAILKEHTALKEKVDKLKSLLGRSAKAQRETKVDFEASQKRLSQALREIERLNQRLEKLQNRPSHLDLLMDFESNFDKAILSVGQSGGEQTSASAPLAPPDEQESALDSMLMNELGEAKNRIEKLEELNSAMMSRSTQLESSSQTLQAERDVALQKVDRLQMELKMAKMEAEHASRAMQDKAASLEEMQMEIDLVLKANAKANSRAAAGEEAFNSHKTDKQKVQQLEGQVQALQEWALASAESKRLVNERCQILENKLRQFQGRDSAVDENLLFKKNGSMVIGAGEIGNFVIELGEHAMKVDARFVVLRWKFDCSPSDHNIHFSIAKGKCETKAEYKNASYLVKDRIITGGAGGETELAFTTDHACTVIWSNEKSWIRPRTVQYTAEIVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNW7</accession>
    <name>A0AAD2JNW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNW7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="304"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="378"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="469" mass="51672" checksum="32027EFC5BA216D2" modified="2024-05-29" version="1">MNNGSNNVAAADRSTPYTAHSFNFQNTSVGCGPSGAAAPSEATSAIPQEIFKNAANPLLAAAANSAYASNKAKDSLLQHMATSFMAANNNKNNRRSMPEAPSGLFDNRNSLDPSSAIAQATAVVGAPTATAVPNTTTSLSRLNAATNASALSASNMLNNGNAFSTPEDLFEPIDFNSSSAFVGGMFDSSSSSNMNGQQDNALSRMLSMALDEVTTGFDSDPIAIDCNSLFNMDPFQQQLQEQQQQVQSRQPMFSQNTFLQSGANNNKRIMPLSVDVTANTPNKRARIAAKEDDDSKAPRFRPYQEKQWVEQFDELLKFKEERGHCLVPHTFEENPTLSRWVKRQRYQYKLKQEFKPSTMTDARIVKLEKVGFVWDSHAAAWEERRNELAAYKAEYGDCNVPSNYPQNPQLATWVKCQRRQCKLFWCGKTSNMTADRFASLNQLGFTWELRHGSTTSTKMAAQAMGNLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPC5</accession>
    <name>A0AAD2JPC5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS23784</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the popeye family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPC5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006916">
        <property type="entry name" value="POPDC1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055272">
        <property type="entry name" value="POPDC1-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101:SF17">
        <property type="entry name" value="BLOOD VESSEL EPICARDIAL SUBSTANCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101">
        <property type="entry name" value="POPEYE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04831">
        <property type="entry name" value="POPDC1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0796">Tight junction</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="135"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1969582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="375" mass="43610" checksum="089519C00D1C997A" modified="2024-05-29" version="1">MAENENASDSSTIARWIQSLRLSLGKTRIIPIPRWISPQYSTYTLSEAFGHSSFILVALSYAVEDFMHLRLIAIAGSSAMLVFTYFHPHGRILWLPFKWNALFILINSYRVLKVYTDRFFAGQMDDLMMYMHDHHFYVMDLIDFAELINAGQRQTFKSGDVLVKQGENNRFVRLVLQGDLDVQRDGITTYLMHQGNFISESGLHAGLLLRGNVNSCCSVIAMSDDVQVISWDRTELMYLMESNKNILRALKAVMSWDIVSKLKSQRSLLANGQVKDPEEWTNKRREQTVHRYKGILKNVLAHPAYLNKRKEELMKYRDIHHIEEAEHVHALKETGWTLAEFDAGKKEGQFDEDLSEPHPHDWKAYFYQLYERLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPM5</accession>
    <name>A0AAD2JPM5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002383">
        <property type="protein sequence ID" value="CAJ1968447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="148" mass="16458" checksum="EED15E06B31B49AD" modified="2024-05-29" version="1">MSDAVHVIAGTPTVTQEAIVPSDDVITPRGRTSEENDAKEHNGAPTYRDTVASLPALTVPLTTDERLMRLLTVLWDASPFRHIAMFNVSIVFDWQGVGLSEFNQVQTAYNAFHQFASGIWGEITSKVVLLPFADGRFTRQQLWIWTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUQ1</accession>
    <name>A0AAD2PUQ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prolylcarboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS13284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUQ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1951880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65153" checksum="F297FECF9EF67398" modified="2024-05-29" version="1">MLGGYGSIAPQSIDEEKSESHSLDPPQPPQGSGGTAPHHADREVQVERASRFLFMLTILAIVAFGAFTTGDFVGDKQGNLTISGTSSRHHRNVLLEGHYDKHEMFFENQLVDHLNPLNKGVYPQRFYKVSKYWKGPGHPILVILGGEDSLDLPMLYPYVRKGLAKEFHAYVLSPEHRFYGKSQPVDDPTNDDLVRYLSPDQALLDVITLIQTTRESLGCSLDKFSTDYCPVITFGASYPGFLSAMLRFRFPQVVDIAYASSAPLELYAQTVAADAYFDKVSEVAEAASTGCTAAVRDTLYAARDELLTQYTSVQEAAKATGFCTHNFPAYIQNITEFISETIIYLVPAVFADFNMAYYPPGPKTALERACHIFQNSNHAPLKKISKLYDLRGQVDYGLAKKSKCFDLSLELPSGPNARIRGADSSGTGGGFTGEIWEFQCCKDLIIRASASVKSMFLPQPFQYAWLSAHCHERFEGVPMEPFRMVSEWRFNDLSHASRILFTNGMKDGWSTSSILQNTNPNIAIFNFPNGAHHSDLGNSWPSSDDTDDIVQGHRDATITLRQWLDEIKAENSTTTTTTTTTSSSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVD0</accession>
    <name>A0AAD2PVD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidylprolyl isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042147556" description="Peptidylprolyl isomerase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="61268" checksum="10CFB6AB2198B8FB" modified="2024-05-29" version="1">MMKLSFVSTSSLLVATTLLILSTNMSVVDAKLMPFLDPFAKEVGSVGAAVDGGRSLSQHETFEQHAQEMKKLLNKRRMEATRRELEMKRRLKAGHPAAAAAAAIDATTTTATTTTTTTTKEANFHRALSTKKSAMAMEGTKGSKKYSTSSSAKSGKGSSSSKGKGGKGTSKSSKKSSKRSSSSSSSSKGDMVTKTQPPTSSPPTSSPTMLASSSPTIMMTEPPTMMSEDQGPISGDTMPISEDEGPISGDAMPVSEDAAPIVSEDEGPISGDAMPVSEDAAPIVSEDAGPISGDAMPVSEDAAPVVSEDAGPISGDAMPVSEDAAPVVSEDQFPASEDYRAPAISEDEEGPISGDMANSSDGGAQGGGEDDTADDSDAATDGEDEPSTPGDSQGSDQDGTADDADSNGGGGEDQGGVFDNIGEDVIDDEDETEDEEPVEQEVETLTDMWEFAMVRTTAESTDSPENFHMTSVVAMAGAIYDYSPEGTINTDEAVGDFSATCIVTSMNHDVLCTYKVHLATPGTFGIGEFIARGHVQDHQTENFALVTGTAFDWSQYTKGGSLTMQPNPEDPLTLVCSLTLRYPKDAVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWG0</accession>
    <name>A0AAD2PWG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002059">
        <property type="protein sequence ID" value="CAJ1960499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="257"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="450" mass="51176" checksum="B1C1E327FF4E51C2" modified="2024-05-29" version="1">MDANADTCCLGKNFVIMSYTPRSADVYAYDPALPPTNVPIVSGATAYDCPQSGNTFILIFNEALYYGNRLDHSLINPNQVRKFGIPLWDNPFDEMRNIGIETKPIFVALKAKGTKLLFDLRAPTDQELANRPHIDMTSKVPWNPGTVQLGKVSIVHKDPIDDPRSNEAELRQLDPIMQEMNEWRTVQQTIVDGERFFQQVGRMDDDARFADVPVRPSFVSTERHTKATAEKLSERLGIGLHRARATLRSTLQRGTRSAILPLARRYQADCMFLRPRLKGKFSTDTAYFNHKSIQGNIANQIYFHKSGFYSCHHLSKVDDKQVGPTLKKFIADYGIPEHLTMDGAAVQVGRNTSFIETINRAAINYHISRPYQPEENPAKGGIRELKQRFYRLIVKHAIPERLWNFVLDRVVDTMNITANYSRYSDGRVPLEVITGITPDITEYMDFTIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWY4</accession>
    <name>A0AAD2PWY4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWY4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="244" mass="27736" checksum="7E9B6EFDE304E04E" modified="2024-05-29" version="1">MGGATSRFAETDWESASAGVKETIDGSMPSEDLSILTLRKNNSIVDQRSFEIRNDVDELLYVSKPIVGSTKWFDLCSASGEKLFCVHTDALHEKWTIFAYKPVWEDQQADEGISDKEKIYRRARIDIAYGKSHGEVFPYIQDWEHDSDFKGVASDKSLLKVEEIKSMTAQFQSYIPQAALHDNALVHPALCGWWVWENTRNRHQMKMHLVKDSDIALHCIVAITTNLVHVEKESFETTAQVLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX08</accession>
    <name>A0AAD2PX08_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002174">
        <property type="protein sequence ID" value="CAJ1964167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="10620" checksum="848267BF40D7D739" modified="2024-05-29" version="1">MKKWQAQIEAASTFKDDDSMVSNGSLNMQIYKSTSKMDSLKHCSQWTKDNKKPFKSNGSKHWDIDLGVHLDSGSTFSLRMNKDYAKPGTVSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXH4</accession>
    <name>A0AAD2PXH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="372" mass="40553" checksum="333FA0498062FDFB" modified="2024-05-29" version="1">MLVGKSKDTSIDCEVHLLSSLQEDSSDKEDASFATLSFESILSPAVGSNSDALQSSISTFFSQISGMSDLTDVNEADVRRLRNEIASLQSKVASKGDEMPVSDLIKYVERLLKVEEELVVEEDNLKNSRSTCRETMDSASEDSSTYSFEEEDFGESLVDTSSVHPMQKLVTSQDMQDSLPTPLVGNKKSLGMRVDDMQDSTPRIGNTRKSLPNHTTSVLSQRWETDCSDRSEFCSPIFRQSGGSSRNVRSTACTNDSLGSASDHGVLERSRRSGGSSRKIRSTTCTNNSLGSASDHGGLQPIPSSVGGFSTRWARNSSMRHLEKDSCSASDALNFKTPIREFPTQNVAGIWNSGDKVKISKSSYGPRTFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAL0</accession>
    <name>A0AAD2CAL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1907478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAL0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="791"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1907478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112370" checksum="50C0D9159FA2D45F" modified="2024-05-29" version="1">MAKTSKAHILPESFGIMPFTERQIKRNKKRRRQRSSTLLFFVFILSTGPQLVSCFICRSPPSGAFSRHQSRAFQAVRNNPGSGDKSGDSRQHPSSKRNGRSHKSINKSSESKSRAIDALSQPNSEGENSQSKRSRNSRKSRRKNPRGRYEKPNESQSPKAPLKAKQKQPKPPKKEKKSESLDSLLLPPLSDPSKSAIGKAEDPLQGGLSSWEDFLSVGNERTKESSPNLPKYSKPKSPNNKGRRQEDGKGAEKFLPSDGGVTQELPAISDLFPTGMYTKAKSLKGKDVEIDTSPPSLDGVLPVSDLFYRSSQSMNDDDDFAHEDDELPFSAEQSDQLTTVHNKIKVRRNKAKGGGARSRDKMKRKSYKHRRMVRRGMEMLVGGVPINADPPQRYMDLVYNAKAVNWSETVVTNSRDFGPIFHSSSVAQLSDVERGLFCEHFVKKTMKWDVCPDDLMSIANDHLLNRPDVDDQDLKDGADDSDTAKSSSYNDAREEKADNWVNAERTETSTGNFGTLTSFKNSLGADAKHLDPNGDPRLGGEIVFSIGVSSDDLQTCTPADAPVLERVLAKGIVDAIDLTGFEVSFESLDFKDREDGATRISGSFVLSLEGSESMTPREMEKRAGQINNALALAMDEGDVQLAMAAAAKEESGWPEEIRNRVVEEFLFDDDDGDGPLYQYGEGSDEESDEESEEEGVGEKKAELSSTARAKKESSGPSSLDVTNDIRDTYDGPFGMPGSKTYNADDLFLGGGNDGVFWNYSEENIQGAPYGGQLGLRLVDAVTQRATERQPRVIAIGDVHGCIDELQALLRKCDYRPGDLVVFLGDLVSKGPDSISVVQMAREIGAIGVRGNHDFEVVRWHQAIKSGVDPPVVGSEHFHIASCLSNADMKWMYSLPWYISSKELSTLFVHAGFVSGIRLGKQNPRLMMNMRSILPDGTVTSKFFNNWPWARLWDGPQTVLFGHDADRGLQQYEHAVGLDTGCVYGGRLTACILPEKRLVSVSAKREYFKYRRKHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBF4</accession>
    <name>A0AAD2CBF4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1922949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBF4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="410"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="446"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1922949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="55709" checksum="D9F69ED4C8B2F542" modified="2024-05-29" version="1">MDLDRAADDGDTLRVQALIDDGANVNARNKFDNNRTPLHVASEAGHANVVEILFQNGANVDALDEFSRTALHVACAEGHANVVEILLRNGANVNAVDDTNRTALHEVCDLYPESDANVVEILLRNGANLNTDEGNWTPLHGACVSNHANIVELLLQHEDIVVDDEVSSSELNSRSTSFGGRSRGKIVELLVLNGADLNARDCADETLLHGACEFGDLDFVEALLDNGADMELVNEHGHSPLHHACSNRHRGVVQLLLDRGANMEVHADHEGTPLHQAGLHAYVDVAELLLSRGANLEARDESGHTTLCNQFFLNGSISVEMVELLMDHGANLEARNDFGDTSLHLVSESPRWRYDTIERARLLLDRGANIEARNNDLCTPLHVACSGGNELGVVVLLLDRNASLEARNNNDMTPLDIACSNGIVEVVRLLLNHQAVADSLETMNDMGCRPLHFAALNNRTDVARLLLDRGAIVDSKTLARTTPLSLACQKGHVEMVWLLVRRCPWLVDGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD20</accession>
    <name>A0AAD2CD20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1918641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1918641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="140" mass="16317" checksum="314D9222BA957D34" modified="2024-05-29" version="1">MATGLKTEDLPKDRFALELEFVQSLASPAYLHFIATTTTSDGQSLLLDSRFKAFLRYLHETWTHPDYVRFIVYPSSLHFLELLINNDSFCRELGQVPFRNFAHQQQYYAWQRRFSDLYGTGEVKTVEVMNTEQPNAAVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD45</accession>
    <name>A0AAD2CD45_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclodeaminase/cyclohydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1921646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD45"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="entry name" value="Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="Methenyltetrahydrofolate cyclohydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclodeaminase/cyclohydrolase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1921646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="191" mass="20624" checksum="2EC569C07F11A639" modified="2024-05-29" version="1">MMALSQQSINEFCKNLAAKQPTPGGGASAAMVAAIGAATAAMSAAYTQRKKDEESGAAEHARQLVEKMNIAELEAMADDDEKAYKDLQSTWKKDCTLSEEEIKAIQDRALKVPTVLVEACHQRILAVNEFLPHCNPNITSDAKVGIHSLAGAARSAYQTVLVNTPPEDEKKRICGLLLEIGAIEQDMLKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDW3</accession>
    <name>A0AAD2CDW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS2360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000147">
        <property type="protein sequence ID" value="CAJ1931371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDW3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042200548" description="Sugar phosphate transporter domain-containing protein" evidence="7">
        <location>
            <begin position="36"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1931371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="58092" checksum="8AA11193D652ED86" modified="2024-05-29" version="1">MAQPTPHCHYKRNSAMLAAVAMLAALNTQMASVNAISPLPSADASISRPNPSSRPNNKTDRPFDGPLAPGLQVSGGSRLKRAKNKIKKAARNMRAELRLRSAATTGTSEASSPTEPLQQQQSQQQSQQQQSQHSQQSQPQQQQQTEVTPTFSNVPEPVWISIHPPRPPTTAAETTKASSSPTMQSSDGGISKKAILFMSLLAIQFGIQPVLVKRFAPRGICKSSVVMTQELVKGVIALFAFYGSTSPKMRSFEISRLTLRSWLTMAGIPAAIYTVQNLASLLAYQNLEALTFNVLNQTKTLSAALCCFLVMGKRQSKVQALSLILLLVSALVIEGVVSFGNIVSLLGNGVATIMPKGRRFTHGVLPCLFASFLSGLAGALTQKNLQGVTKKKVPSSVIESTTTVTTTVTKATPINPYLFSMELTVASVLVLTTSLFFSQDGKQIGQHGFFHLWTPKTMIPILTNSFGGILVGLVTKHAGSVQKGFALIFGILLSGFLQAGSHGISSAQIVGGLLAATSLWMHSCSRSLSSTMPKLFLANKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFB2</accession>
    <name>A0AAD2CFB2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000228">
        <property type="protein sequence ID" value="CAJ1932983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFB2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="198" mass="22465" checksum="791BE47F39BF6D80" modified="2024-05-29" version="1">MAKHVTFNDIVQARKTISRQDYSELEAHHSWLSPDEMEKMTERCFQTAARMESGKESKRESTYRGLECLSDKGKDKLDAVINSCTDAVLDEQDRQFYLFEKIQDSEMIALASMDCSEECSKKALRRGQSDAREAKRCYRRMRDMETSRTGKHNNNNGSASSFSVSDEHSAGAIPILKTGNAKGDIRESALPQFQEVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHD1</accession>
    <name>A0AAD2CHD1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000225">
        <property type="protein sequence ID" value="CAJ1932892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042162998" evidence="2">
        <location>
            <begin position="24"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="816" mass="90056" checksum="13B0DD7ACEC2CC1F" modified="2024-05-29" version="1">MKFAASTVAYLALASLSFLHADASERAHQHLRTHVEEREVAHRFPSHQTQGEGDGSPHVREKNHSAGRYEDYPDPDYKDRGYEEGPDPRYEDGPDPRYEDRGYEDPDPRYEDPDPRYEDRPEPRSEVYPEPRYEDAPVAREANPDGSCPFIEAIAEFTDVEIPQVTNSDEKELLVIPMPNGIGGEDINIIDFLNDKLKDDAILPVIKPGDEVPNSSTNMVCKHIDYIDESVDVLVAGIPAGTKGLCLAFNPCEQIYAVSAGFVKVDIPLTNPLLKLGFTLNTIGISINKDFTIETHNEMWDGGSMDAVSKVDGHFALKGTLSLKFGEEDSIFEFSVNGRARIFVDVDPANDNTHLTAFEHMDDFEMVISGLIFPKIVIGKFPLVLTFNFSKVLNAAIDIHLLVDEQNTQLEFAASVNTDLMNICEVSPATKFLCKYFEQASAGLSLQVQSFVNINQEFGLRFAISGELDAPEFMDIAFKQLFPKWPADGHAFDLSIWFELNADQEIETCVDAGLGPMCFTPKCLNNDDCGGDQICHLFKCQAKLPDGTVGCFSDYDCQNFCNGGICTGKLDNGQMCNWEDIRCKSDHCVGNICRECAKHSDCPSGEACRGTPLQCRELHDNGSMCNWDDNNCASGHCVSNICRECAKHSDCPSGESCRGTPLQCRELHDNGSMCNWDDNNCASGHCVSNICRECAKHSDCPSGEACRVDIVLVTFAQSATVVIATASLGSGATETNADRKAMMGIGVMVRTPGATVIPANGKRMDFGILVITDVKETRSPPFLLCESQTCHIPRAAEPMYKAARERDVKTHFRLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ08</accession>
    <name>A0AAD2CJ08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transaminase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS2138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000015">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042050103" description="aspartate transaminase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="56"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1930891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="47122" checksum="973E192934459897" modified="2024-05-29" version="1">MFSALVLLSSALLVTAFPVEAASKTSIDTIWNGVEMGPPDAILGIAQNFRASTDERKVNVCVGAYRDETGQPWVLPSVRAAEGKMIENNENKEYLPIDGDAAFVEKALKFAYGADAPLERIAGVQTLSGTGACRIGGKFLAEFFSGNKIYLPVPTWGNHHKIFGECGLDVQTYRYYDRSTNRLDLDGMLADIKDAPDGSIILLHACAHNPTGCDPNSSQWRALMDLIKEKGHLIFFDSAYQGFASGDAEADAQALRNVMKEGLPMLLAQSFAKNFGLYGERCGTLSVVCKDAETKDILMSQLKNIIRPMYSSPPKHGSSIVKTVLSDDALTGQYYKECTQMADRIQSMRTRLVEAIKEAGSTHDWSHVTEQIGMFAYTGMSAEMCDQLTDEYAIYLTRDGRISIAGLNDNNLKYVAEAVHAVTDGKSITSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ81</accession>
    <name>A0AAD2CJ81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000480">
        <property type="protein sequence ID" value="CAJ1935553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="44"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="263" mass="29786" checksum="E371DD245B548C8B" modified="2024-05-29" version="1">MYATIAKRFYSPGLKQQIERFNCEICQLNKVANVQYGQLPEQHTDLVPWFSVAVDLIGPWKIDVNGRELEFNALTCIDPVTNLTELAFIKNKTATHVASVFEMLWLLRYPRPYKCIHDQGGKFICKAFQAKLATWGIHDGGTTSKNATANAICERMHLTVANILRTRYNNAAPNFQVAVEEVKRALAACNPLTDRICALNFHCTISVNICNRIRTSVFRIQLSSISILDQNFSTNSVIKLFSLRVLPSQVFIDLILSLLLHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL17</accession>
    <name>A0AAD2CL17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000424">
        <property type="protein sequence ID" value="CAJ1934963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF20">
        <property type="entry name" value="IMPACT FAMILY MEMBER YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="210" mass="22471" checksum="33D3E2347FBBE151" modified="2024-05-29" version="1">MSETAAQRTLASGSFNTEMEVKKSRFLGHAKHVENWSEAQTYIDEVKALHPKARHWCYAACFGVNPVSARCSDDGEPTGTAGQPILNAINGEELSDVVCVVVRYSGGIKLGAGGLIRTYGAAARLVLREAPVDILIPKSTFRVKISDAGYVGSIYDCVSKVSGGVTSGDEYGADGSLSVSITCDLEEFDRLQGGLRDATRGSIEFLEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL28</accession>
    <name>A0AAD2CL28_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidylprolyl isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL28"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041927920" description="Peptidylprolyl isomerase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30471" checksum="D45A924B58DD78CF" modified="2024-05-29" version="1">MTRQSMPMSSLLSSVLFPLLLSQESTADNLLYIDFDDHFEPPMEENVEVYQACIGDTNGFGGSAADNTLTIQYYQEITYSIDGDDSPAQIVRDLDLATVDYLLASRRISCVRPSPPAVIATATDENNNRKLQPQLRRKPVGLSANPDDQVLELDCQEPPTDGDRCMVVDSGFSVFYMGEVDNGGDDDDNGFEDMFRTEVADAVDSGALNSANDQIIDIRITDPATYRPYQGDPAIQRGPADLTPEDDSTVPIVIAAVIGSLVLLGAGAAYARSKRSASSTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMK6</accession>
    <name>A0AAD2CMK6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000846">
        <property type="protein sequence ID" value="CAJ1939773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="216"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="435" mass="51129" checksum="68BB7EEC74CD2F2E" modified="2024-05-29" version="1">MPTYSLPSDRQREERGQLATQRHQERAYIEEQAHVLRRSGGYAISAKLVQRTAIQKAFEYFQDETWDFGYKSGKRMDSAALKRILNEVRVITGYDVSWRQFRDWLTYYLQFGHLPSRKKAWKGEQGRSKRLSFTANDDECLQRIIEEQPQLYLDEIVTEMKKLRGKIWHPSTLWKRMHDLGYSLKVAVHRARQASENEQALFYQRLDQFVLDPQQILLIDETHKSRNASRRRRAWGKKGIATVIPSYFEEDFLQQFTIIGVANIFGFVPEACEIVHRNERLENRGTVDTERFELFIEKKLVPILGNYEEKEPNSVVILDNATIHMSDRIEEMINDAGAILLFTAPYSPDINPIEYFFSTYKKGLARNSKKGLCMFDAHFDAIHHVTPEAAMNTFRHCLYPGSDEFCERYGQNDDDDEELFMIMTVIALFIWRKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMU1</accession>
    <name>A0AAD2CMU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMU1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="806"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="672"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="701"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1940086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1234" mass="138676" checksum="53217E501EBC4D44" modified="2024-05-29" version="1">MLRHDRLLDINRYRKYREKGRISPRGNSSISTGSSIGTASLSTSPLSFSSSSFFGSSKSEDDQDSGMNQINRNENHLVHYASKNNLLDKTRRQLQNKAEVSRQNKVERSRKLEKFEKFKRAKKTFELKKKLLEISYPAEPSIAQLSQVSVTKMGVVLGSSNYKASVPKRITIVESPAKENQSTVSGSRKSIDPPRNLLQISTQTSTPRKAPTPRNAPSREMQSTKPIDPPRNILHVATQVLSPRKAPTPRKAPLRGKKSMSPVDPPRNSSLIITQALTPRKAPTPRKAPLRDIQPALSSDPPTLRSPRTPRAAPMTPRGFAPLNLPSMKELKKQVEDRYDRIKREPPSGNVPTTPPVEKVLESTSIEDRHDSPSLYSQSTCKEIVLYQKQDERRATGAEDLSLQIQATHSMQSTLGFDSMSSPYQDDKGQTVARVEETESRAHFCVPSTLMADPYNRKVEGTETHPICLEDIIDLSDATEPPPTPKTLSKPSPLQIETYTTTYSPAFNSFDYTFPPKMQSSRSTKIPTPSIRFDFTPSNASVRPKSTSKAKAGTATFSFSTPSPGSRQPPNEMMPSSIGSQKGLNRSQSTSRLYDRDPYSGLAKSFASTEFWPLNQKRHSTFQFTKTPSNERNSHSRKLTPETNQHSAMVMLSPESKLRLSTSLFVNPSVSATSTSIIPPSETKAPSSEPRRQRRSIIHRQATDKERFAMQRGLRKPDEKPDNHNTVLIRDRRPMTPRKQSVALQKANDEQLGQGDALENADSEAAQRTARMIYAQDFYRMIQKQKLRDRYLNKGRNSRKRQRCGGNGVSFVVRKRPIADTEVDDGEYDVVNTETSDAQGIIVYETKVLSDMKAKELVPHSFRCNEVISDLKSMDDLYTRVAQPLVDLVNGGGFATIVMCGTDGSGKNENRVAIEERLVKDIFVSQREAKTVTVQYVELCGKNCYDLLSPGSFVEVVDKEGGYFKLEGAKVETISTDHEMLRMFSNAKRRLVSRTNVRKQKDEKSFLLCQIKINRHGVSPTGCLSLLECPVTEFDGVWVPTVDTTTVKTTFDTLMQCISAKIARRTITNPFRNINNITKLMKESFETRESRVCVLSTISPVATETEKILTTLSSMCNVMRGSKPRHRATKNGPLQIHNSAVLQDESLFLPRQWTNEQLMSWMTKKNLVDNSVSSKVNGRVAMRLTKQQLNQTFYDTANINKASKLYDALRAENDRIARLRVKRRMSISLQEYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN27</accession>
    <name>A0AAD2CN27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS7017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056452">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23546">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="414"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1107"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1127"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1940388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1146" mass="126669" checksum="C4CD636F0329F53C" modified="2024-05-29" version="1">MTTESNLGRGEKVGRGGRGGRSGRGGRGGRGGRGGRGGRNGRGGRGNNKAKSSYDTNDTNAEPSDLKANAPEFKPGVGTSGPSSSSEQSKNTNSKGNTQKQNSKNKNNNKAKGKQGSKGAANNSKDNDPKGVNQKKGGKENAKNDKKNGNEPKESKDNPSNTKKSKNEPNEKKKNTNDQQSRKKGKNNSNSNDNSKKESKARNNNSKGGNQTSASTAATPQKPSIPPNQCQQTNDLNYARGEHITIFHVGEKPSIAQAIAKGLCNGDMIFRKKILPVHEFTNPAFPKAPHAKKVTHKVSSVAGHVFSVDFPQQYQSWESVDPAELFTAPIARKPCKGSVVKHLQDEARGANFIVLWMDCDREGENINFEVLDCCMHLMKGGAGVANYDRVYRAYFSAINPSDIIKAYNNLGKPDKNQALSVDARQELDLKVGVAFSRFQTRFFQGRYGDLDSSVLSYGPCQTPTLGFCVQRHIDIETFKPEPYWTLELGVLKRGRMLRATWESGRSFNKNKTIDLVAKAFEDNPNVMVTSVITRDKKQGRPIPLNTVNLLKACSKALGIGPHSAMQAAERLYLSGYLSYPRTESTAYPKSFDIRGTLQQQAGDARWGTYVKELLALKGHNTSRGGVDMGDHPPITPCRSAGFHELSGDMARIYELVVRHFIASVSHDAVWRSTKVTFEIESLGPKGNFFLSGKEIVSKGFLEVLLHKQYGDEVENDEDDEEERTMPEFRKGEVIPLLKTNTGSNSSKIQMSTAAPVWASLDVKEKQTTPPGYLTESELIGMMEKYGIGTDASIPTHIQNIQNRNYVRLESGRRLLPNKLGLVLVQGYHRIDSGLVLPKVRSDIEGQCNRISKGEMSKDDVVEKAISMFEAKFDFFVKNINRMDVLFGSSFSKLEDVGKAFTRCGQSRRYLQFIEGPPPRLYNRHTETVYPLPAGGIVKQWSGRQCPVEGCGFELSMYSVGAPPRAFPLCPNCFNSSEWSLREPEEDPVDREDQAKEQQIKRMAGKALTLECPLPDNHPLIEELYVSPDPDSDGVFILDPHFGPKWRLVSTRDATIIHLPKCIDKVTILDEKDEVLGCHKMKIEFKAGESPLESKESKYTCFFPTDPVMQSSSRVFHGSERTNATGRGRGRGRGGRGRGRGGRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNM3</accession>
    <name>A0AAD2CNM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF19">
        <property type="entry name" value="CATALYTIC_ HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="8"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1940444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="32900" checksum="62FCAD1206569DD6" modified="2024-05-29" version="1">MAMTTNIIDSHLHVWASSKESRTFPYAEGQDPPESLTDVASKLALLEQMEIAGVGGSLLVQPINHKFDHSYVISAIKEHPEKFKGMLLHDPSLSSEEAVLRLEQLALKGFVGVRFNPYLWPSKGDGWENMSQGSGLVTFRRAGELQMPVGIMCFRGLQLHLEDIIQLLETCPDTTMILDHFGFTSFSEDGNAAFQELLKLAKYPQLVVKISALFRLGDSAPYEKVRKERFEPLLQAFGPNRLMFGTDFPFVLQQEPSYAGMVKLVSSWIPSDDAQSAVMGKTAERLFGAWGQSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPX7</accession>
    <name>A0AAD2CPX7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPX7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="25822" checksum="B7303C426E5F8348" modified="2024-05-29" version="1">MRILDYQYGAPDMHESKPQPVTPDETSSSSSSARVEDRGETTLPLHHQVQATQRMGTETCVPYILVTPTKSASSRVEASQNTPITTASLDDESLESSVLPSPSPRHTDQLNADHVRFSVNYLNLQHLSPTNIQLEKHKIEVVLETFIPKLVLEVMGGAGAVWGFSEAIGLRTSMNAWFWRPVTLFAGSLFFIRWYRQVKEFSRLYDLRHKRRSTVEGETAHLLWQENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRS1</accession>
    <name>A0AAD2CRS1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001202">
        <property type="protein sequence ID" value="CAJ1944120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRS1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23569" checksum="188CC5883FA51A3B" modified="2024-05-29" version="1">MPEAKEGEDHIYMKITGMMVQILIDMAPEYRKYVVLENGKRVIYVRVLRAIYGMLQSSLLFYNQFRSDLVAKGFVFNPYDPCVANKVVHEKQHTIRFHVDDLMSMDPKVNDEFAKWLNMRYGSIKACTIVRGKIHRYLGMTLDFSVKGKLKIRMDDYVKNMLEDFPIKFNKDSKQETPAGNDLLEPGKGKLLSAEYRVARVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS54</accession>
    <name>A0AAD2CS54_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12980</name>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8995</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001225">
        <property type="protein sequence ID" value="CAJ1944649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS54"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="201" mass="22541" checksum="F8C09F9966B36C0C" modified="2024-05-29" version="1">MDWSLVAEGVRPPLDRPPTAWNDTVDFMDVAVHVQASGFLDACTIHTLTVAHHHLAPNSMVLNTWIAPPCNPVKKRLYGFGRVSKDHGLNHDVVNPRSMIHFAWPYLSAEDRLTAIQASFVWKQYAELRRFACVTSLKSLQLPRLLVADEKVPTTLDPHRAWLNSAALLRFDFNHGDFVRWLGGPTKGVTSILNGMSLNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSH8</accession>
    <name>A0AAD2CSH8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSH8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="343" mass="39502" checksum="863F30F99D152E16" modified="2024-05-29" version="1">MEHLNITPTSSSQHSTKIRERDLLRLLMTREMATAESSPVEEGVTRKVSFEDEDFDVAVKSPRGLDVFDSFRLSPHSKENKISSYARETIVEPDLSAFWQSNIAVKLFCPEPNETPEDAVNKMIDILERATTHPKNCWSIVKGSRSDLRTLKDEDLFRVFTKAVYIKETLYLSRSTINEGNARFSFRKCCNQVVQNMGGLVKPHDITAGYTVGEWFRDFRRGRGFTHYKCQSSSSSSSLQQEVAPLLTFFDEEPDLYKVFKFQLVSDIARLSAKRALYMFLKNIIPMASSKRRCESDDIILDYGLDGLQQWHFHEWLKDQDFVGETCSDSGEIVWTYMETVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTD7</accession>
    <name>A0AAD2CTD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="10">3.4.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Imidodipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proline dipeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS9239</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline</text>
            <dbReference type="Rhea" id="RHEA:76407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:195196"/>
            <dbReference type="EC" id="3.4.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480:SF2">
        <property type="entry name" value="PEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1945095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="499" mass="55466" checksum="4C6E1B55FBBE25CD" modified="2024-05-29" version="1">MFRENRTKLAKSIKSTMDESALIVLVGGPSTTRFDSDNEPVFRQESYFWWLSGVKDADCALILDEDGRMTLLVPNLPEDYATIMGHIKSKEEWKELYGADDVDFTENLEQVLESKVVSNDKSTKILLMEGVNSDSGNTYDLAPEFKSNKLVEQQDKTTLFPILAECRVHKSKLELALLEHVAQISSFAHSYVMRNLKPGMMEYQAESLFMHYAYFNFGSRLVSYTSICGCGPNAAILHYGHAGEPNARLIGEEDNCLFDMGAEYQCYASDITCSFPANGKFSAKYLPIYNAVLQAQITVYEMLKPGVSWVDCHKAAEKTILTALAEMGIVSKGPDVSFDDLVELRLGGIFMPHGLGHFIGIDTHDVGGYLPGHQPRIQLPGLSKLRTARLLEENMVLTVEPGCYFIDHLLDGALNNPALSKYLNEQKLKPYRGYGGVRLEDVLAITKDGCVNFTVCPRTVEEVEGVMAGGKWPPMKDSTPELRRINLVRASPMLGPLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU89</accession>
    <name>A0AAD2CU89_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS9690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU89"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="68"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1945546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="658" mass="72268" checksum="A1F7539F89F0B3D3" modified="2024-05-29" version="1">MMVDEEVQEPKIKTKTKIKVRSNPKKINRTIVDPTGFHVAEVHHAIGKKGVNRNIEAAWMAPRDHSVFEFRNINYIVGEGKAQKPILTNVSGRVSDGSTVAILGPSGAGKTSLLMALSLGITSGKVTGSIELNGKALTNQSFKDHCFLVEQSDHHWSFLSCLETLMYAASLLLGPGNHSAVVDSIIEKMGLQSCKDTKVGNDFVQGLSGGQKRRLSIAIALLKKPAVIMLDEPTSGLDSAASVAIVSELRKLAKTENLIVIMTIHQPSTKVYNDFDQVILMARGRQAFIGEAAAAHDYFETIGHPMVHMTNPAEFLVDLVNSDFTSEDSVLSILDEWKQHTSETHRSKNETLVVGSNDDFHQLIKRKKSFLHELSTIFGRHALLVARDPILYVGRIVLLLISNTIFALAYWSSREKVQAQAINFYYANAWPISLGSMFAVVAVFGLNAEFKSVIREVKNGMINPLTYIIAKTVLVLPVMLLFGAAAISTGVYAILGLKANYGIYLVLYAISMFVFECIAEVLSVAFINPLMGMLCFLSIWFTSFLFGGTFLPPDDLSVVIRWLYHAMPLSYTFNAISYHVFSGEDWPSCVPDANTGAVCVEFDESPDEAPIALILESLSKIIPNVSGDDNRVEAMAIILGMALGYKILYVAIFLFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUB1</accession>
    <name>A0AAD2CUB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="171" mass="19094" checksum="D8D9438F20A640FF" modified="2024-05-29" version="1">MSSSRQKKNKTSYLNGDYSNLADLAEKVDWFTQCHSPAEIFSFFSKDEGDEKDNSVIAEEEHQELQMDSLDESLTNASNSPYPLPASCEYCGAKSTHECLPACTRPKFFLVKKRPPFLAAPTLKTEWNGSQVGVGDNGDNDDVDAFETASSTISNFNEDQKNWMSEIGWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVC7</accession>
    <name>A0AAD2CVC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVC7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="742"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="269"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="872"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1937746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="898" mass="97147" checksum="F9CF32B73CC9923C" modified="2024-05-29" version="1">MSCIEKFGNTVEHTIGGFFNKVGLSVGNRPRLTILICFLVTALTGYGFTTWETESRQQKLWVPQETQAQDETERYQNYFASNARFNSIIVSGNDGNVLTKNSLVQAMEMHNEIETTVSVVEDKNYTLTDLCVKAGGSCASGFQGVCLCLVNSILKQWNYDLELLKSDNDFMTTLNNYGSKEGLEAVLGNPNFDSNGTLVSAEAFTITYFLESRMEVVDGSEVDPINEAWEETAFLSVAESVDAKYSDINSDYISTRSFSDEFGGAITGDLLLVQISYVIAFLYLGANMGSIKCGTGSRWTMAFSALMVVLLSTGAGFGISSIFGFFFGPVHSLLPFILLGIGVDDAFVIVNAFNRERKVARSKEDNEALAQRCARAMARAGASITVTSLTDLVAFGISATSSLPALASFCAYASFGILFLWIFASTFFPATMVLDERRQRDNRRECLCCLTRKAPLEEDEDTGFEEGAVSRYFRNYHAPAILSVPGKFATLIVFIGLLAFGIFGMLNLSVEDSERSFIPDDSYVNGYFDAADKYYPSTGIELAIVFEGSSDIYASREGLATLDERLAGKSSSPPYIAEPVSDAAYTNIMAGFSSYLKTAGSNVNVTLGSDGWPATEAEFVTALTSYAGFGGAGSQYTRDFVLSADAKSVDAIVVKTEYIRLTKMSGDKVIDDADRQIEAMDATREMVSSWTDLPQHFTYSEKFIGIEGFKVIKKELFLNVGLAILAVAIIVFFTVASPTTSILITLNVAACIIEILGFMYALGIVIDSVSVINMVLAVGLSVDYSAHVGHCFMVKGGEDKNKRALEALADMGASVLNGAISTFLAVVVLLFSSSYVFRVLSTQFALTVGLGVLHGLVALPVMLSVLGPKPFASAEDPDSSGKPANTDKISEDDDLDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCG0</accession>
    <name>A0AAD2FCG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved Oligomeric Golgi complex subunit 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1915089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="2">
        <location>
            <begin position="241"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1915089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="754" mass="83129" checksum="FE4AAD0D1BF46F9D" modified="2024-05-29" version="1">MSSRRRSDAKATENDHNQNSVLSAKVSRALEVRSDTPAMKAALDALAHLPDHQDDLFSVDSRSVRVAIEQDALQQALFLQEKLRGLLDTVSDLRNGVTEIAAIAHEVEDAVSMNVMADSKPPPSDSNSEAKENENAAANTAADIGLEAEQKLALTLSEAFVQRNMAKKRVEAVHAFLEKFDLSEEDSRLLDHYAFEDIETSAVNGMAFLAALERVRVIRLELGQKSRLSDADASRLGASSTLRMMEGLAMKQENAYERLYHWLQKYLRVFGNESAGPNALDEDVLDEALSNPFVLKSLRALKNVPAFHSHLLELIASSRRSEETRRFLIALTSGYQGLPPIEMRAHDAVVYVGDMLAFCFQAFSVEADVAKGVLRTVADDDDDGDEGEVKTPLALDEADYLIEKPMTAAEMVIQSMGGVARPLKSRILQVIANLSRRQNDDYESDDDMEEIEEEGSGARHRLAQLYEICGLLLFYMSAIGKSISKLEDWEVSTEKNPLLDSLVECLEEGTQAYDASLRVYCSMFEQLNLLTGDSESLLAHAMIIKLADLRNTSPGFTTTVECPADCKQALSLDFACKILVEASLPSCKSLDDTVLLKQAIATANESELGEEITLSLRDKIEIRETSLINELVQKETSDVLDLCGLGSLLSALDRFNGVQVDGMVMSAHPGLAPEDVQVAMKEFYTSLYSPPIPSFESTIRDPSLRKSARKKIADSVCDSYKTLYDTMTTSERGGYDDLGFLSHTPEQVSTLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCH5</accession>
    <name>A0AAD2FCH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1916571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1916571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="443" mass="52350" checksum="8F1C02FF9279D0A7" modified="2024-05-29" version="1">MDFNPLFRNRIGHKKYCAQCHKAEAYQEFVTCNCAVFHYCSTTCKDFYGIEHRRDCRLLARFRGKGRNVQFANLMMKNEYLCNKTKSRSKTTEMRSHTYEQVLDLYLYRFEEIKAMGTTTDVGVQAQQDFVLIKMRIPLLLAALGYDDLAITEVAVMMDFQGETPGRIPRTKFDDVIQDIYEERGEVYEAWPTCFILPIVLVKLRHVLAWRAYTTFISRTNRFPEDVRLCIGEFLIGHDIRSSTASLYVEQKQQLRQAISLIKQQDDNFASILQDHQYNEDDEEHDHAEDLLSYIYENDDYGFNDYGLFQFFRGCFRDTEAMKALAAEFINEEELEAGEEMTWERRPSVLRTKKEESKDFIQNEDLEDGVEISWERRPSVRRVKKEQRKDFVQKEELENGVEISWKRIQSICLKTLSTDFESEDELEDDWEPLQANWLSVKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE27</accession>
    <name>A0AAD2FE27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS2545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000180">
        <property type="protein sequence ID" value="CAJ1931788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007378">
        <property type="entry name" value="Tic22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33926">
        <property type="entry name" value="PROTEIN TIC 22, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33926:SF4">
        <property type="entry name" value="PROTEIN TIC 22, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042070391" evidence="4">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1931788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="309" mass="34233" checksum="CCBC44883C8660AA" modified="2024-05-29" version="1">MLQHLKWVSSIFLLLLTLTFGFQGPQGRQGTVCCNHHNDCVNALEDIKVESHGRRQILKSTALVALGTSSLGKEATADQPSTQDLLLRLRSIPTFCIVNPDGIPFMIFDGQSSATGYFFLSFDVAAQALQDARKKDKKGSEIWSNANIVVVPLAVALQLALRKTQREATNNGATMVTFNEIVASSEGVEDAKELDGGDKGKWSQRGRVPLFHFDTLVLENGREPRYFNRADLLKEWNRQNPDKSPPPVQVSNLLDLYRVCFAKNDFSKVERLAIMPVVETNQVASSLFKSSDGNMPKYNLDKVFLVGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEW5</accession>
    <name>A0AAD2FEW5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000302">
        <property type="protein sequence ID" value="CAJ1933772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="17584" checksum="5616CB9C1A777A37" modified="2024-05-29" version="1">MSSKHRLTRSFRTLSALLYILNIVVSVRFTRTLGYLDVLVGSLVSVACLIMLFVAIEAPTPVVTRLERSRIGENLFTFRGRYIMDLLVSLFLFAMGVYGVIMGICTLVLIFGIRFLGVKQPDAFNEIFRQSDFDANNSATDSYTLEDTYDTEANSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEX0</accession>
    <name>A0AAD2FEX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS3467</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000302">
        <property type="protein sequence ID" value="CAJ1933802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000183">
        <property type="entry name" value="ABC transporter ATP-binding protein yjjK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008775">
        <property type="entry name" value="PRK11819.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858:SF1">
        <property type="entry name" value="ABC TRANSPORTER-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="ENERGY-DEPENDENT TRANSLATIONAL THROTTLE PROTEIN ETTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042154450" description="ABC transporter domain-containing protein" evidence="13">
        <location>
            <begin position="17"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="79"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="401"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1933802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="632" mass="69392" checksum="16E111FDE4AB2DAE" modified="2024-05-29" version="1">MKIFFLLCSIYTVTNCFVPLAPARNIRTPGRSSHALYGKKKKKGGAGGSGGKPRGGQQQQEKQSVKDARFDAATRSFMFTLVGLTKILPDKSKKILDNVNLSFYPGAKIGIVGLNGSGKSTLLKIMAGVDTEFDGTARPLPGASIGYLPQEPVLEFETVQECIDEAVQSSQAILDNYNELSMKLADPDITDDEMTNTLEKIEVLNDQIEAGDLWELERVVNRAMDSLRVPSGDAKTAVLSGGEKRRVALCRLLLQNHDMLLLDEPTNHLDAESIGWLEQFLDQFKGTVVCITHDRYFLNNVAGWILELDRGAGIPHEGNYADFLEAKEKRLAEEKKHETANAKAISAELEWIRTNPKAQGNKSKARLNRYDELLAAAAPTELRNAGQIYIPPGPRLGDVVIEVSNLKKSFGDRLLIDDLTFSLPPAGIVGVVGPNGAGKSTLIKMLTGKEQPDDGEVKVGETVNIVSVGQERMDELNGEKTVFEEISGGLDEIELGTQSVMSRAYLSWFGFKGQSQQARVSNLSGGERNRVQLAKLLKAGGNMIILDEPSNDLDVEVLRSLEDALQLFAGSALIVSHDRYMLDRICTHILACEGDSKWFFFPGNYAEYEANRKERLGETSIKRITYAPLVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF13</accession>
    <name>A0AAD2FF13_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1894479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF13"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1894479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="16672" checksum="EBD7E62F5DBD99C9" modified="2024-05-29" version="1">MSLHFTKPTTRPEWAASIAVCLFGTMGAIQVGIAVGLLPSDIVWGGANDELTFQASIASLAACAILCGMAHIVHRRTKPGPSKFIRGASWFVAFYMGLNTLGNALAKTWLEQYIFGTMTFVLCICSFVVASSKPLDDDDPSTEDVSADATPYGTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFB2</accession>
    <name>A0AAD2FFB2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000358">
        <property type="protein sequence ID" value="CAJ1934680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFB2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="636" mass="67264" checksum="D8E8D950C35D8943" modified="2024-05-29" version="1">MAGEVQTVSRMDDDDLEISNTLTNDSTEPKEEKVNKTTPTESASELSSASTEQIIQESQSRDENETDVLDNAQHQDQDERNHHQPEEAIIIKEESSNSDNNSEPLPMTPTTAPPNVETVTSMDSLDLFPARPDSNAELIDATKLSETAVAYSADDDEPAVAEAVPVEVGNDQEATRPSFAARAGAAAATAANGLSTALSNLSASSSPRASPTASPAIKSENEDDHQASSSSSPSNIMDRPSLVARAAAAAAAAATATGIVPVLSTNLSGTPRTSPRTSPSRTPARTSPISVARTWPDENVDDDSFFDNGEAIPGSLPSPPRSSVGTGGLGAKPFPPLPTSNETAATTRSPVDMDAYNPSPSTSPMAAPENPNANTNTTMDIEAPGSADKNDGEAQVLSVVPTMVEDNYEPKKVDIDVDEINNGREVPPPEDSAHHLKESGEDNATSQHSLAALKAGLKTKKGKGILLACLLLLIGIGVGIGVSVAPEESSNCDAVRNGYPIPDENQYKQLDLNWIVDVSTTEPWETSLLKEIKTEFQSVLLPIMAGCKDSFVDEDDARVANGYVINARDMGDCSGSLPRPCFSILLDFSIWVKGDDSTNSMEMIRYLTSSFGTTLADQIESQSIVQVAELVLLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGE0</accession>
    <name>A0AAD2FGE0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000734">
        <property type="protein sequence ID" value="CAJ1938540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGE0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="184" mass="20634" checksum="453705CABB0B3296" modified="2024-05-29" version="1" fragment="single">RRNRTFKLPSDSFIRSFIHSISIQAFKHSSIKHHQHDYRQRQQRKGRRPCQQHKLVFFIASFGKIKLSVLDTIAYLAANAGSGDDDNDDDETSAIAPTALTKLQAALDEVPRLENELKNVAISVAVFIATAEHYLSREKPSLKRALHTLQECVTARNIAAFEKLASESSLLSSSSSSFVVVQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGH1</accession>
    <name>A0AAD2FGH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000569">
        <property type="protein sequence ID" value="CAJ1936871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="118"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="283" mass="33045" checksum="83E7C197B4EED4CE" modified="2024-05-29" version="1">MSTILEYFSKGYQNLRELQQSEDYVSLNASIHTIVFYTLILTVVLEVWSLPTLQLLWNKQPNGRELYAKALFWNIFNQYALAIPLYSVVGTFMTRNDDYHYYHDNNAMIRNLVEVVWILGGHAVGYYHVHKAFHLSPKWYKYHKFHHRFNSYVPPSAANAVEPVEYILAYLLPFVVTLALWPPFFTPKIHRHNVSMATLVISVLNLLVHTPKLEQKYLVASTTTSNNNNNNNNNNNSWTRWFVSTEDHLNHHRKLKCHYASPTFNVDNIVDDVKDAWSSATLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHE7</accession>
    <name>A0AAD2FHE7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000191">
        <property type="protein sequence ID" value="CAJ1931944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042145360" evidence="2">
        <location>
            <begin position="20"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1931944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="564" mass="62240" checksum="0CEAAA56B34E2385" modified="2024-05-29" version="1">MKATLQFTIIAFLVPYVSSAEFFVGYEAQTRVTDHAAIDIDQQKIDLMLALGRLENVKKIYEQGGNSQSIARVNIIDSNIDVNTVAIPSGTEVVGKSVLGNQVYGTLLLGLGPNDDEALIQYPPKTMESNRNCQVGGLVSMDLEMTDGCFADSGELRVLDSDIHFEYSYNSQFDNFNGRTIQRFSLFAEEEMAACGKNCPYNDFAKFVNYYGEYDYADKWIQAAFFEKSTSFDRGNIDFSEVGKKALEPAVQIATKFMNIWMYTIRMMESALDTCEVPCNDDGCKYDAVHNWDQAVAFHAGSLQDEGILLYAFADVMCRTFRSCGIDGSMRVGTSFANNKAIHHFKLGQSYILQKDCKNARISKEEIVKAMTIPLIQATLFTAYAEGRDSGKLSSGDQATKKVRAASFAASVLPIVHHCSEGDASIIYENLGIENGDDVHKEIDFPAVKEAFERNYQCMGVTCKGVGGIWEDGAYAKHAAPCQYEPVDETARSGILFGHFLAILLMPLAILGSVVAMRASRKRRTLKAAEENRQTVTGILDDIGLEDVQLDGEQQDTPSLPSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI91</accession>
    <name>A0AAD2FI91_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000305">
        <property type="protein sequence ID" value="CAJ1933838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1933838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="325" mass="35447" checksum="02318A594A5195E5" modified="2024-05-29" version="1">MLNIHMDVIKIPGVNLYQAKDQPNKGKGKPKDDKKKAACYVCGKEDHMSPKCPDRLLPESQWKHPKRYVDYGKKLNLNQIGATVPATVPGPSPATSVITGGTLSVAGSVNTPLRPAGTTGNQMIQVPTGNQMMQVPSGMQLMQIPTQGGGTVTVPYSMNANGEIAFSGMQLSQQGFSGAQVRQRLDATQARTPQVVKTGYFDTSNVFHDAIKGKDENGNDVYLIPCPTRTTNVELQSDWHYASESEDLPDLATEADRGMQFIQSRRVERDPFGLLDHVIMDRGCTNTTICNGELMPGLRQAEKELDMHTNMGSRVSRKISASSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIM9</accession>
    <name>A0AAD2FIM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIM9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="444" mass="49665" checksum="1709D7BE92D2A1CF" modified="2024-05-29" version="1">MALVAERDVLRGMGRGRHAGNQRWRQLVRNSLVAYNGANRDDRMLMAGLIVLEVQDSGGRFLEHDDNVGYLEMSNEDAARMTRQCFINLLYRMRRINDASRFFNNWANGNVDQLCDTLRTTRIVKDLTAKFSTNANFAKLVGALEENQSLKKFSLDLSICKDFESTESMISMLCTAISKHPVVSSLTILIPALGKDSTKAITDLIRVSITLKELRVVDSMTLSYTATAAPQRNGDCASSKKLMKALQENQHLKILAIPCRIAGGLIRFSDFMNYVWNSPRVESASLLGMGEKDTTDAGLKEVAELPRRQMPLIWGVDSRMANLCQESVCQLLEAHPEILIKPAVTTIGSTIVNALPPRVQFWAAFHRGGRYLLKRPYLSLSVWPHVMQAAKPDLIYEFLKQGPFFAGRTGGFAIQSNELPAPPKKKWISRKRKSDEISADLADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIP5</accession>
    <name>A0AAD2FIP5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001088">
        <property type="protein sequence ID" value="CAJ1941839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="158" mass="18220" checksum="54AFDC7824D014F7" modified="2024-05-29" version="1">MKADYKEHDAILIACCMMQIKAKFNTDEGLNFIQQYYINQGLKKFGDDGKDAVDKELRQMLLRDCFTPKFVKDMTASERKKFQSAMMLLAEKQFEKTIKGRLVYQGNGTCEWLLREDTASPTASQEAITTTCVIDAHKGRDIMTLVRIKQNVLYRECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ71</accession>
    <name>A0AAD2FJ71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="99"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="208" mass="22571" checksum="9F30755AF4467D03" modified="2024-05-29" version="1">MTVKVISGVRATVDSKYGISFCRKTTDSPVIIKEVRKEGIFAKHGLIPGMVVKAVNGVEVEWKRPTEAATLLAQTDVGQEVSLTVECFTGTVHRSNKYQKWGLTLKNSTKMSGIYISGIEEDGLFASTELTAGMKVIRINGKRCPREAKDVINMVAQTGDDLELVGVHAMPRSPEDKENSSSQQAAPRSTTLTESAAVNRQHPALALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKQ4</accession>
    <name>A0AAD2FKQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS6037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000691">
        <property type="protein sequence ID" value="CAJ1938232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="229"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1938232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="336" mass="38099" checksum="9B6C5EA866DA09C0" modified="2024-05-29" version="1">MVQETTNHDKPLVEEQTTRKKRKEKKRKLEDSSGQDEKDLRRASRRAKRQEKQDLLSKVPKVDGDGIQYTKIQIKRMLKRVKRGLHPVPTEHEELERLQNEAKMRKDDEAEFAGLTYQKEDEKGVTQGDDEEEETGEVIIEAIEESFDASQASEEESMKDGNDQVEEDKAPFVKKAKRSKPVPPDYTCQACNNKFKPAHWIYDCSMKVTVRGRNQKKKKLRGINEPDSRKIFVSGLPFDVKPADVTSLFKACGKVVNCKLIKFGDTGRCNGQAYVSFDTDEAASKAMKLSGTMIENTSDDAPKKKGGKSSEPSKRKQLKLKVSKAANRRATSMKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLM6</accession>
    <name>A0AAD2FLM6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001091">
        <property type="protein sequence ID" value="CAJ1941866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="95" mass="10791" checksum="3046C2E1D0E71A04" modified="2024-05-29" version="1">MAVVPPFFTVHDDMVICGIDDVTLFQGRTQAERIAYAIFSDNFATTMDSTMDKLNEEFKTLAGLTIAQGQIRLMPAIKKNIRAFIQWCRDEIRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMW8</accession>
    <name>A0AAD2FMW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="43721" checksum="68C0D08C03025C9F" modified="2024-05-29" version="1">MKVIGANAFGICSSLPKIRIPSTVETIGKLAFGDCINLEEINFAAESKLKQIDKLVFSGCTWLSDINLPQTIKEIGTESFKECRNLKSIDLSHQLKIIRHNAFENCVRLEKVKLHEGLKIVESYSFYTCFSLLRIAIPSTAKTIEDEAFNSCSHLEEVVLKPGRLKCLAYGAFGYCSKLESISIPSTIEKIQKGAFTHCNLRSVELHPDADIEIEAHAFGDNKQLCNISSQNSPSARINKNALRSTSEYSWDSEEAYLKLKCWESRYFGYPVHRPKLCYHASTTTVVELRKAAIECKATVKPDLGYSSFGSDPDDGSDASDVSFGDPALDASFNLTPFHVLLSAAKRRTDLLEVLLDKFPLHACSDNGKTCGVIGLWNSWLETGMETPGKWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQF5</accession>
    <name>A0AAD2FQF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS12087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="924"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="855"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1949424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="987" mass="109390" checksum="73CBF2ACC1DBF32E" modified="2024-05-29" version="1">MAEGIQPNPPPGEVTSIEVSNDDSPPSVVEEGTNNNAVSEEPPSADNDDEEPPSLTNEPPEEESSTMMMPAVKHESIEENEPGLAVEPSPMVAAEPITTNNNLPMGSLLDDDESDNDNDEQENSAPTAEDDDNNDDFVHVDNMEDSNEDNLRDEESKVLNGAEILFSRSTKEQYNGWDNLRWMAYSGTRKLVFFETVYRYNEKPKSFMNFLAGEEYSARKLAVYEEPSVILLLRSPENMDELKSALCVEHDSQVDTTNTSYWIVEAVVDTNTCKLRLSSLTTVTSIVKVQENEFRRKSCFELITPLSSIVLSAIQLRHGGAVKTSFIDSGAFLETSSAELVLQKVVCNAHRPKEIAPQTTSDLSWKHQIILGTLHSYVILGNKDLLDQGIAKARKAQELEARRMGESSSMAASKYLDPRIIDAFDESGKTPLHYACANRFTMGVLSLVSAGANLDLRMEPYHLTPCHLCAQKLDDKSLMCILQQNRRPNVVDEFGRTPMYLAITEGHTVGGMADPKALDRCLAVLDAHGGDLGDLSTFMHPICHHARMWNHESLAVVLRHVHHRYPLFPPNGDVDDRKRIGISASANFHYPIHSALISFRENLKMFCEDRDPQELHSLCVDAEARLSNTLQTLYSCGFEPNERIETILDQFNGSEQLSSYVGFAPIQILYRAGLDVLEHKDRIPETSHKRIVDTIGKLAEFMVSKGTQFAMDVPLSSRPRATDSEVIADNAKLVERSDQLKIESNKQLTETLGGIDRLKAAQKSWEVRKPVSTESKAFVFHTDNKSLIDNSLAPGGSDEKSCFVCWKQFGKLVNRKHRCRITKRYICDFCSSKRILSNGEEHRVSDGQYLSAMLAGTSPAPKPAPPMAAKRAGSGGATDAKTNQVTSRLDKLEAAEQANRDSLFGSFIDNASKAVFGEEEEADKAAAQAEGLSGLSNQLGETRNMLHQRGEKLNTLAEKSDKLASASEDFASMAKKLNQQSQGGFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQL9</accession>
    <name>A0AAD2FQL9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQL9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="118" mass="14069" checksum="7508BD8D2F8D9879" modified="2024-05-29" version="1">MVKGRQGLYLEAWKFSVYLAIPIVASVYYSDPETQRYWADYWQYIKYPENPNTNVKEKIQELAKEKEQTRQQRMAYKEQLRSLQEAANRTQTYSEETSNDASWWRRAGRWIGGGSTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQX3</accession>
    <name>A0AAD2FQX3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS11964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF30">
        <property type="entry name" value="SODIUM_METABOLITE COTRANSPORTER BASS6, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1949177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="457" mass="48762" checksum="18D8735514383C05" modified="2024-05-29" version="1">MALRQFTSATVLILSIFIQLYCTTTTIYAFSTSSSSFLRHHHHHHHCHIGIGFRRNQIPCRRQREYKRLKKLNLSQSVDIDNDDHSNVEKKNDKKTLASNLLAKFSLLAPVWTSMAAIYAITNPSSAKVLGSPNVMQNALLTLMFAMGMAILPKDVSRAISNPRILMTNAILCFGVVPLLAVGLSQVLRLVAVATNTGSSLLFSPSTQVGLLLLASVSGGQASNLFTLIAGGDVALSVICTLSTTLLGVLATPLLAKVLVGQTVDVNLMGVVKSVASLVLVPLVAGLGLGHWCIPTRVHQRFIVPCMPVVGIFATLILVAGGASSLSWKTTNPSLIIATALPSTLLCLVSGVVALQWINFQNRRGKSQSNKKNKKNNDDDDPRITEAAKRALVVETLSKSPTLAYFLASRHFGTEAAAVPAAAMVTLAVLGALIASLWSALSPPPFVADDDTMLVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQY5</accession>
    <name>A0AAD2FQY5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQY5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34123">
        <property type="entry name" value="OS04G0578200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34123:SF3">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042068429" description="Plastid lipid-associated protein/fibrillin conserved domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49311" checksum="D6E7044A82181CCC" modified="2024-05-29" version="1">MARVDNVIATLLAFVFVVHGLSSSSTEHASRRDWLRQTTGAAGICLFGSISSPSSATASDSVQELPDVLRKISLAPLGKPQTFENKSLNLPLEELASRLTRDLTVGANGSGGYFLTGDLSTDIFKDDCVFADPTNNVASLSRYQNALRILFDPASSQIQLLSPLTIHTETQPKTISGRIRSRGYIQLPWRPYVSAYESDIVYTIDDETGLIARQDQVWDSKSPSKALRESFTPSSFLFNQPPPKSSLKPSPAEPKAASQLFDYINGRRPNEYTFQETKEIEGLIQEVVDTGKTKSEITNKPEFQRGLLPGRWILAYLQPGPNGVGIDRRIPFPDFDFNDNYQVFSESSSQQQPQQVTNIGQVLGPWIDVKVSGMLQEEDPSSTRIPKRFQANINGGKLCVHAGSNTEGACVGLPIKGEGIFDSLYLGERLRIGQNINGGGARVVQIRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRB3</accession>
    <name>A0AAD2FRB3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRB3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="244" mass="28085" checksum="31EF1C3ACDEF10E3" modified="2024-05-29" version="1">MIESNTNPENKSHSALQDFMTNVLQVQKHPQLSVVEDNAKSPTRRKQGNKKAAPILQFTTDLKESQLRWPVDHKASASIKSKKEMDRWGDMHFEPLQRKLREEQQTKRNETCKVASNHRFNASRFNDRPLPSSVIGNGHVALLRQNSLERHFLAVAAEEEREQEEEDEAEEEHLPTVPEDESVHAPHVVLTSPKRKRQRHHMQKKITHKMETESKADVQDKASKGTPKPHKSDAAKKQSKPRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSY8</accession>
    <name>A0AAD2FSY8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS13397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001799">
        <property type="protein sequence ID" value="CAJ1952117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSY8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="79"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="477"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1952117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="78374" checksum="E4878FAA2A63431B" modified="2024-05-29" version="1">MFSNGAEVSNASNSRLALEESKVSSENDVAGCIRALPQQSSSLSHDSSSSQSKTPRFNSKNLRSNLTREQGDRDPLFFYEVVNTLGAGSMGSVASVRKRTGVIGGSARIGIQEAVKRQKRNKECLEIPVIGNFLRCCLDGDLVLAGHSSRRSLFVRASEQASSLMWPVSEQQPSVLSSISIYDSYQGSNKSAGNAKLNSDIIYAMKSIHLNRVTDASFVSELRNEISILKQLDHPHIVRAMETFEHRNQIFIVMELCSGGDLYSRDPYTEEDAARILSSVLGALSYMHSRAIVHRDLKYENILFVNDSPKAEIKLIDFGLSKVYGDNAQLTEGVGTIYTMAPEVLKGSYTTKADVWSVGVIAYMLMSSQMPFYGRKRRHIVEQILSCQFDFRGRRWKRISDPAKSFIEDLLVLDPDDRSDAKSALSCSWLNKRFASTTREPLQEEENMARSAMLRYAGYTKLKKMALMVVAHRSSTDEIGILRKVFQKYDSRRDGSITFGEFCRALEEFGHSEEDLERMFQAVDLDGSGRIRYTEFLAATIEAQGAISEERLAEAFDRIDSDDSGYISAQNLAEMLGQDFPADEINSIIQEADLTKDGLISYAEFLALWETKNEETRDLQLKLLGTPLQLSEFEFLSYRESKCSVDESFTSVDGMNGRASFIVGKHGNSRQTKLPYDGNEGEPSGEHATLEEAFLTKDYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTH3</accession>
    <name>A0AAD2FTH3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001821">
        <property type="protein sequence ID" value="CAJ1953165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTH3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="448"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="893" mass="99803" checksum="259011F6CC3C4A96" modified="2024-05-29" version="1">MRFGMDTAPPILMQELRSVLSSEPWAGVFPTPIQVSDMVRLGFLPLLPQELAIGPYCKDLMRLCDFQYPIGLMQEWVNNPRFFSAKFTGSSRGLLCWHVFVPKAFAREADLILAANLDLRKPSCAPFQAPTHYTRDWQAEKDELVLGKQCPQLQSLIEAMRERTRATRALTAIYRIPIKLLGMLTSAAIEKFGRLTLLRFLLAVIVTGAQAKKAEDAEPTKPPTKTLDVLSDSESSGDDDDDDSPPTFEWTTTIKKSLFASTPKPVEDKKKSLLTAPKSPEDNNAWIDQLAQMDLTKDRPSPLFFMILPAEEDGCYFVVVRQRYLPLAMNVLDSLPSFLQFHLGESSFPNFIRVIKNWSATDLAYQNRKLHVAWVPLELRSRCIDDPTDDQGPQVRDPMDFLLCMEDPVEILEGTLQIDIHAKHVRDVDDGLSVIGYLDDWNKSQAQLQTALQTIETITDEKNSLNRDLQSVRDELEAMKAAQEAAAAMSELATDIRPIPMLTVDVPTGPPGQTRVSTTTVLSPSARTIASPATAQETDGEDGEDQPNASSPMDTGRDGFGDNHLARAPGSARLAFQNINTIPNESDDPKQAQLNHWIQSECGKGFHSAVAYNTHQPRAAHSTTQFGGCSTSAFNKVSHRVRSSGDDSLGRWAWIRLQGRTRGVGQRDLVVISAYRPNPPNDGHQTVWFQHKAHFSRTNRDAEPREAFIKDLSTAINKWRDDGCSIILGIDANDDLSSYSPKSFRFRMSEVGLVEAIQSKHPGSHQATYQRNLRGYPIDGIFATPDVPILAGGYYPFDEHVASDHRGLWIDFDLNSLLGGHQPTKSTHVPRRLVMHNKRVVQRYVQLAEQGYMRYNIPGRLSTLGFDVARQQGVITKSQAVRFDRIHADAYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV30</accession>
    <name>A0AAD2FV30_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV30"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="378" mass="43300" checksum="477DED4E29FFF1AC" modified="2024-05-29" version="1">MHVEWLIHHLCFDENFSSAEIDIDLHDADVWDRLIRSLTRSIGLEELKITRSSDYQVRSDEDLEDLFRAIGSMAQLNRLELSEFSTLDLSSGRNTFENFLGVTDLQIDISEDSTPLSADVARSIVSIPKLRNISIATPCSFAVSNLFSPSIESILVEGLSELTFDDDNFRQFVEDLERDRVRQLSRLDILCVTIASHQVPLLANMLKQNSTLVELRLSLSIPNENVVNECCEEIIDAMSYNTVLQKFDNYKSRDIKASLATKKAQNGMLFHNTTLREFGLFGDDAFNDTAQEKNLYLRLNAAGRKRLLDVGPGSIHDWVEVLCDEGIRDNLPCLFYLLRMNPSLCQSYRYEQKDGTDETVHQQWDENEETRQRKKICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVL5</accession>
    <name>A0AAD2FVL5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS14748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1954153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="29425" checksum="7117327D8F1CF3E4" modified="2024-05-29" version="1">MRATDDENAVETDEETRKQELTTKDKKKSKKDKKAKKSKKEKKEKKKRDVDVEDKSAPDHHQAEETVISIGEQEPKKEGAVEEVADISKEEEEGEDNSIFEDPKIKELEAFYRKALEAFKTDKTSKDLRRAKTAAKKAWDTALIEAAGPGFEPLTCRNCSQLFLFGDKDKFKEKGWAKPSQCKKCTFKIGIARSKDRKRVDQKQNMCYEFQQTGECSRGDRCRFSHLERHIGKKRRIELDAAKEEALDAAKKETSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX27</accession>
    <name>A0AAD2FX27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="123" mass="14180" checksum="384D20D2EE639718" modified="2024-05-29" version="1">MKQQQKQTKAKVTFQSRKRATSNPQVNDVIHPNQFKTAISFYTPNRGSNSVRKTRYRQTIACPNSPRIEESKECCRQHSPDDLQQRGRFLVWPTSIKVEDANMPNLRSRMAKAESRMTKAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXM4</accession>
    <name>A0AAD2FXM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="307" mass="34695" checksum="BE074BE167D901A9" modified="2024-05-29" version="1">MKLRSQRVIGGPFDEPFETECSVSSSSTSSSSYRRRRGNKKGSTIQFKNLNDADDANADDASKRYHQVPELRRAGSSTVSTSESSSLLYIDDDDDDDYDASTILSDTLPELTSAGGVFYRTILTQFEAVFMNFYWNGLPWEGYQCRSWKAGLTGAFFCLPMFFCRSNRYEQAWWILQALTSVMADYYYIHTRSAWHGVDRIVAQLSLLGLVARAYFFVRLWSVALLVSLPVSCFTLATRAKDHNDISRWHWCHMLWHIVAPIGCMTGVYLSYNCPNGTVQYSPLDNFCLDTSASTAEAATWFGLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXZ9</accession>
    <name>A0AAD2FXZ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="332" mass="38277" checksum="67E30041D62232CB" modified="2024-05-29" version="1">MGMEIAEGGDDSASTPQSKCRGNMLNKLCLVFICAAIGFVTLYASPTMSLDATGVTVVDVSSSSSSSDSAGGRTKAQQKIRQISIIGERNSGTRWTFGHLGRCFNHSIKVTTTFTRYKHWFQFPDYKRYKHNTIVVAQYRNPYTWLKAMQKVPHHSPAHLAYRADADWEAFLSKEWTMERIGNDRWPNQTEPCQQFFEWKDIISCQRYPIPKDEIKEHKFSDHQPFYEMRNDGSGEPYNNIMDMRTDKIRNFQTVKEYEGVSAMLTMQYEYLVSRGTQEMLDQISELTGIEPSCKAYPAQNRSARTLSPDMKAYIDKHLNWTVEGWIGYKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYM1</accession>
    <name>A0AAD2FYM1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="547" mass="62255" checksum="7BF3733EA0BE5476" modified="2024-05-29" version="1">MAGSTKKTSDSVVFGIGNKTSWMKKYPSTNTFRTLLKKNYDSYWEANQEGKEGIIQGILDRFLPDAFFRLVDGELSPLDKKLAKNEVKMSMAYMRSKLKEKKRKMRNKEQEQVEGTPCADDLVFHQGVIVGSRNYATLKFEEMLLLHLARLRNTEGKICLKKGGARSIARRILQQQKEENPGQKYFKYVAGTNKYFKYSEEQAFVRAVTLVETVQQTHNRKIVPLEKRCLDHGIDLSEEKEQDADTTADTTLLEAGNDSSLQRGHRKNRALHGTKRNYAEVNVDNANETDGSKHPFRRQAREDNKENEDRKSNATIANNDGGDDNDDDDDSVRIVENPNSVSPPVPTEKKAGNVARHPDISTSTKKSRLEISVVNNEDCPPNHMIQDPSVAKNKSPVDQDQVESTNAATDSPIKQEEEQKGHQSDPVLLPTRSDGTNQTEENHQSKPEFKELQDENAELKDENAELKRRLAILQNQKDAQSIEIEDLQSEVNVLRREKAKEKLAHKKKVEEVDALEQHCEEMEEELNQMRMNTAHAQGFSECFDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYY5</accession>
    <name>A0AAD2FYY5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS16702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001943">
        <property type="protein sequence ID" value="CAJ1957410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYY5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF18">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN GCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="12"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1957410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="464" mass="48155" checksum="EFB59786DD4AB2E7" modified="2024-05-29" version="1">MVQMTLQDQAVIKALPGNDTCSDCHGKNPEWASVSFGNVFCLDCSGVHRSLGVHISFVRSIRMDSWAPKQLELMRAGGNDKLNAYLKSKNIQKTTPIRQKYENDHAQLYKEILKARVEGRPEPTSLPKKTTSAPSSMNRPMGAVGSSMGGGGAQDANGMERLAGETEQQYVARQTRLRDDARERMKAKFGGGGMGGVGSSGMQGIGSNPNYNRNGGGYDLDNVVSGVSSAFSAGLSLVGGVAGAAVNTVNSDSISSVRGSVSTVGGSFWSSLSTGISQVADTITAPDGNDGLADLQQQFSSNRPTQSKYSGFGSDSSRNGNSGGFNGGQNFNSSGAAKPTMSRIPPSNGSNPLGQAPGMPGEDPNGMERLTGESDEQYVARQTRIRDEAKARMAAKFGGGGLSSASSSSNYPASSGTNFAAPSSRPNSSASPAPRSGGFGAATPPRKMSADKLSSDDFFASFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZB4</accession>
    <name>A0AAD2FZB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS16984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001959">
        <property type="protein sequence ID" value="CAJ1958004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1958004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13429" checksum="93B79D482EB5C12A" modified="2024-05-29" version="1">MSLQKLLDPLMKPAARFYKARLGKELNKMGLRYEDLMSRDEPEVNEALELAHPDVVEGRYRRLKRASDLAFKQKNLQDYAPDMVLEPFKLEFTEDVDKILARDVEFDLLNNSKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G074</accession>
    <name>A0AAD2G074_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G074"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="43289" checksum="498F216E0160FCB3" modified="2024-05-29" version="1">MCVNDRIISFNAWYAQKRSLVSTSASDTKEKNSSAIVSTPLMDLRSADDRAKRRLAFPNDTNFSVIPFPIECLKERSFELPARHVEFAILVRSSDLPKASSFLLGSTDNARKRAQKPWLVTNILIDDAGLWEQAEKLGLVRCDEEEVAYPLPRLWQPDKMVETVVLPLLMESLRSVEDPSYKQEGNMTKYDHAIESDYEVWDLASGAARDVTFLAEELKAAQVPFRRVVGIDHRYNAKEQGIVNAFWERRGVGKLTSCIKMDLSTLEKGAEELLKNRKVIALLAVRFWKPSLVEAIARNSSGSLKSGTIFAISHFCKPYDGAPWKFEHPTEKTVLQRSQLKELFETSKGEDDSATWEILYEEIAMDSDHGRTMIHFVARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G126</accession>
    <name>A0AAD2G126_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G126"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="416"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="584"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="733" mass="82112" checksum="1CB8E918D7421656" modified="2024-05-29" version="1">MDLVDVVGLAKNAKNLAKQTVNNSAAENRQFFTSTVEHAANKGVKVMGKTQAGQTILDGGKFLEKTANKGVKIVGKTQLGGVVLDGGKFVGGAAMVVGGTLTDTLTDGAGFVGGAVLGGADLLGKTAMMGTELLGEGINLLMGEDDASAFFHEKPEELEGYDNDFDQMLPERFQDPEKEKEVRPSMKVEWDEVSWTHMDGGPRGHSLAVVVDKTVSQRKLEIKEERENNGGKANKYESDEESSVESDKTEDIYFTDAEIRAKEKAEKRERKRLRKERKRMSKLARAEADTKAAAAKMKEDENFEALGKSYNFLSASERGEFNADGSLRVDGANEAEVTGGAPIQSLELPSNSGHMDGIQMKMRSKGLWGKLRQNVAQRAIVKTFQSNVKQNNDFFDAFDDLDAVDEMGDDPMGAATAMLNNEHDNEKDKVENLRKQLDEYEANLEKERKEVEEERKRIAAEKKELETQFKFESGRNEKLTKQTHDLKKELGEELEKKNEFKLQRELEELRAENEVLQEQVERHDSILRSLHREKAIREKREKRKQLYGGNNPHSSGATVQTFRSSGTGTVQFDDEATIVTYVAKSRRSSNIKVMEENLEEMNDELEARQKVVEMQVMELENLQKQLKEAEDRSGLKPLKNEFLELQKQKEEILQKSEEEKAELTQTLEDKKELAAKHAAELSRLKLDQTKKELKAAQEVEPPAEKGGLFSMLWGDTPKDEISDADVALSKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1Z8</accession>
    <name>A0AAD2G1Z8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS18418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1960001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1Z8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1960001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="366" mass="40978" checksum="B84BB5E6579BA796" modified="2024-05-29" version="1">MMARFPERLFQLLKLVDENGWEDTFSWVNNGTGFKVHDRNKFEKLLLKKHFNTTRYASFARQLHAYGFDCVRAGRQTGIYSHPHFRRDDPIGSSALKREAGRNVSKAAVSRRNQECQDGGLEDHFARMRNFVLSKDAIKLAPLLLERPNASCLPNMQKDNVGTADDGSQHWSVMSNLYDTVRSQVADRRKNVIPSPLPTQCLHFNRKETGPCSGISAGGTSLNGSYGMHNPHKSFWTLSTNQKRATSALSMASVNDPTPLHMIVDEGKSNDAFATGNLICDEEEDSDLDPIPLEEAAFDQIALKPPVEDDYSFRGKNWDPTNWSPAGSVSGKDNDARRSPIQDGFFLEPRPINEMVQDPGCLSTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G276</accession>
    <name>A0AAD2G276_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS18412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G276"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1959995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="298" mass="33525" checksum="2B63A8983119DCBF" modified="2024-05-29" version="1">MSMPITKPKSKTTTSRISFPQRVYNVLNLCDDTHQEHIASWMNDGTAFKVHDIAQFERELLPKYFNTQKYASFTRALCSYGFDCIRTGRQTGIYSHPKFNRNDPEAPSMIKRVKKTNNNAKASLTKLSTGCHGFSLGDRKRSFAFPSLMNTTQSLMNEDADASVFGHLYQTIRSQIADRTPLSHLVSSDESGDESAGEQSPYNPIVRSASCLLATEDYDMTTFVEQNQDEQYAQEIADSILDDDFTPIPLPSSDGYDSIDADFEPLPWLPHSASKICGMLDNAEDEAFLSWSREVFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G326</accession>
    <name>A0AAD2G326_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002079">
        <property type="protein sequence ID" value="CAJ1960899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G326"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="122" mass="13677" checksum="265661397D0CCB57" modified="2024-05-29" version="1">MIRYKGGTMMHNSVATLYGRIATILNGFNHKNPPPTNLSDLAGVAYAIEQRKKRGASSNLWELQTARDKSGQTEATFQDHPHHQDQEEELLQDSTNDNSKDSKTIAPPKLQRSRPLEPSTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G343</accession>
    <name>A0AAD2G343_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS18973</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF48">
        <property type="entry name" value="SNF2 FAMILY DNA-DEPENDENT ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Chromo domain-like"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CHROMO_1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="390"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="481"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="594"/>
            <end position="660"/>
        </location>
    </feature>
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        <location>
            <begin position="1252"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1585"/>
            <end position="1735"/>
        </location>
    </feature>
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        <location>
            <begin position="2129"/>
            <end position="2191"/>
        </location>
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        <location>
            <begin position="2456"/>
            <end position="2530"/>
        </location>
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    <feature type="DNA-binding region" description="HMG box" evidence="11">
        <location>
            <begin position="390"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="240"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="897"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1850"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1984"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2230"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="171"/>
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    </feature>
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        <location>
            <begin position="272"/>
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    </feature>
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            <begin position="290"/>
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        </location>
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        <location>
            <begin position="318"/>
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            <begin position="336"/>
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        </location>
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            <begin position="903"/>
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        </location>
    </feature>
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            <begin position="932"/>
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        </location>
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        <location>
            <begin position="951"/>
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        </location>
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        <location>
            <begin position="978"/>
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        </location>
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        <location>
            <begin position="1854"/>
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        </location>
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            <begin position="1881"/>
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        </location>
    </feature>
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        <location>
            <begin position="1986"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2013"/>
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        </location>
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        <location>
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        </location>
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            <begin position="2241"/>
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    </feature>
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        <location>
            <begin position="2330"/>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50013"/>
        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CAJ1960967.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2557" mass="292889" checksum="BAD6E2628EA35827" modified="2024-05-29" version="1">MSDGGRRSRRARAKVVNYALEQEFSDAEDVFEDSDKEEPVIAAPTPKRGRPRKSKGAAEGVVLVQQGTDEQGAYVPPKTMYTEKGYDPSLPPIRERFPFLPEYEEDGSPRIELIVGRRPVDGNDGKETKDDDDDEENEEKADTEEDDDEDEEDSDAGRGRRRGRRRGRSTTKKEKETKKKNKKESSPKEKESTIEYEYLVKYKNRSYLHLEYKTGADLESMNKSAKGLYRRYLRKLASGNHDEDFEDPNFDPSYAEPQKILAETEQELTLDLTDKELMKWEEKREKEIAEESSSEDESEDEDKDKDKDEKEGDEDKEDKDKDKEGSKEGEKKTEEHEEEEVEDWDENEDVDFSQLTVDKLRKIVNKDGPYYPKIEGCDNPYRDGYITEPPKKPRASYLFFQCTMRSYFAKRNPKATQGELMTIVGEQWNSMNEEEQAPFIQLAKEEVKEYEKERALMERAQRPNEMWQPIRRCLMVLETLAKDEFSDIFLEPVDLEEFPDYEELIDQPMDLGTIRTRLKNKKYQAPEQFARDMRKVWNNCKIYNRHGSAIWHVGDYMSKQFERIYHEWVLGFRERYLRWADPRARPWEGKHEITDAEAAARKRAELGDTPKKTVKQTMYLVKWVGLGYEYCTWETKDDIGRPDLIAEYKKLNNASTDEPDMPVAVVQKVLDDAEHVSRENAGGNHCIPEMRAQLYAQTRAFQFCKFAMDLPEKLTPECGPKTQASHNSAKYPPEVAECLHSLTYKVSQSSAYSNLVEYQKKMPPLLAGEYDTIIPVTAKGLMMNVGEVNGSVAFLGYRQFPDGSKGPAEIKTLIRGAGDRIIAVDGVSTINKTFQEVIGFLRESGKNKFAFMRFLEAKLTNGDSNLTSFGRLGRYATEELKDKFALDRKVILASRMQEKEEEKETEEVANDADGEGGSDDGSEASEGSFQPDSDEEKEEEEDENMVLEKNATVDENMRDVETNVKADEQPEPKSQTPQKDDKKSEAKPQEDLPRHRAETTHSLAYRLLDLDVGYSSDEGGDEDCAFYLDGVDTTFTAKTDIPPELIEATEKAKPKGVKDDSKTLPVKKNEFSTLGDRGKLIAAVNLTSEAPDPEDFDRFPNISTKREELARAKAAGPAVSAMDVDAEQKVVKRSTVKIEQINVDTNEVINVWANAEAAAATLQIPLNELRQVLRGEYDEDLEEEIGGFRWQYALAGATVTAGKAESKGKGSKKGKEAWLQFRDRLYDPNEPHLYKNENKLRDYQVEGVNWLASTYYKKHGCILADEMGLGKTVQIVCYLEHLYRVEKIRRPHLVVVPLSTVEHWRREFEGWTNMVCCVYHDRQRVWRDVLREYEWYFEDRPHNSDYLKFDVLVTTYDTLIGDFDVISQIPFRTAVVDEAHRLRNQKGKLLECMKEISARGTMQYGFQSRVLMSGTPLQNDLTELWTLLNFIEPFKFPDLDDFQALYGNMASKEQVEGLQGKISPFMLRRVKEDVAKDIPAKEETVIDVELTSIQKQYYRAIFEHNHAFLNMGSSRSNAPKLMNIQMELRKVCNHPCLLEGVEHREQDRQFKEYQEEGKFEGKAPEDMQHMLNEHLYVMTSGKMVLLDKLLPKLRAEGHKILIFSQMVRMLDLISEYCEFRKFPYERLDGRVRGTERQKSIDRFERDSNSFLFLLSTRAGGVGINLTAADVCIIFDSDWNPQNDVQAQARCHRIGQTKDVRIYRLVTSRTFEQEMFDRASKKLGLEQAVLGTFDQQDDSDKPTSKEMEQLLKKGAYALLEDENDEIGKEFCADDIDNILAKRTRTRVVEGTKTASWLNKSGMVVSKSKFSSDSKTAGLDMDDPLFWQKVMPDFVTPSIMIQKLEDLSDEIFGTTGKKKGKGRGRGRWKRKKAGEEEKEQDENEKAIEVEDDGDEKKDTTETESKTASDAEDEEEKEEKTELTRTDLKKVSKFISDLKSMMEGIFDEVEDGSLPSEEKAVASKLLLTISVKEKLFSEEQRHIARSMLKRLEGDRRRRCRTSDAADRGHTPSSRNRGGDIEIREELRIVKKRKKRRKKGEDPNIGDDGYKVHSDDEEDWSDVGEDLYDSSGTKRNTISRKEANRRRQWASDTDEATAAGRPWPVFPRTMVSKVLESLLEIVMKIDEDSGGVFSVPVPEDDFPEYYEQIKQPMDYGTMKKKLDNGEYRSAQAMQKDFILVMQNCLKFNANDSDIVKEAREQALMRPKLLREAATKHDLFLAEDGSVFEILDDEKKKGTSGNSGTPKKRRRRRKRGPDGELMPLSDEDSDVKPKKKRKSKKSLGMADDADSGDDHGDMPLSSMKSRKKKTRIKISVPAGDGEETEPKSKKRQREDDEDDEFVDDDVEDDNDDDVEDLPMPKKRGRKSKGGNENSTKRGRKKKEADTDGDEVDPDSVSAEAVIEGEKDERASTALKGERKRLGDTFEDARKFFTKRGAWELPSSADPAKFKDVAKKMLSKLSILDRYSIFAKPVDEEEAPGYYEVVKNPIDILAIESKIENGSYGTGSEACKTLYEDFLLMFDNCALYNDDDGEVIEEATRIFGLLPETYASVCESVCRKYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3I1</accession>
    <name>A0AAD2G3I1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3I1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1961467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="166" mass="18279" checksum="D30462AE3A03AF91" modified="2024-05-29" version="1">MKKKQSPLQKLNALDKIDSELVQVFETAALIANVQGKDYISTTTFVQALLHCSPGKITELFQKLPEGSLPKEAQLEAMSEIAGSELLDGMESFSPCIDSALSNLLHPGAERSISSEDVFVDIARYSGGKSTMLLRSKGVTKEKVESMVSDLGWELIEREELRQVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G419</accession>
    <name>A0AAD2G419_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G419"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="329" mass="36516" checksum="C8562A4AB7B220D1" modified="2024-05-29" version="1">MTASNALDEEISKFCESAGYKVKSIDWAGSSDWASFRKVSLQDTDKMYFVKTSTRSAKEMFEGEALGLQAMYECSQQSGDDGLTIPNVHHWDDFSGGSLLIMDFLQLGGRGSEKALGKAMAQLHLAKPNEANGNPKGAFGFGVDNTIGGTPQPNPWTDGGTTEDWIEFYKKHRMEHQIELAGDKSCAKLWEKDIAPRLHLLFEGIEVKPSLLHGDLWSHSFPFLLLRCIPGTSGNIGTASGKPSIYDPAVYWGHHEAEWGMSWCASLGIKFWDGYRELIPQDPGFADRKPLYDAYHQLNHYNLFGGGYLGSAQGLLQQVKKKLDAKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G468</accession>
    <name>A0AAD2G468_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS18815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G468"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1960630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="420" mass="47197" checksum="3A740580241701C2" modified="2024-05-29" version="1">MPKTDPKACVICAKSSNHVCGKCKVMNYCSRDCQKQHWKLHKKTCGKPVFVDRPLEVGDKCTRCLETVEDDGHGNPVLMGCRVPHPEHLQQNCGSCYGGGGMQLSLMCQACNYSYRRTGSGDAPISETRITQGPKWCFEGSHTLLPAERLGDRRVKKDLVVITANEDMQEEIDALDGNEEITVLRICSDGLYTEEYAPSLNIKLPNLIEFQLEDVSMDQIVLTPDLTPKVKIISMQNPTQCEDPDFVIECSELKRFSCHYWGPGNSDWVNTMLAHATKLESFDSYKLRVDYLMFASNKLDNIRLHRAECLEYLELYAPRLTMLNVQAAYDLDVIKFVDTHPVLSKKLPKNFRFNRELEVNTVNACLGGEARHAIEHHPRFYGGLDDDDSDDGFGGFGGGGNPMASMEAMFHQFHSGGGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G487</accession>
    <name>A0AAD2G487_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G487"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="456" mass="49964" checksum="489A0DC6DC6BA91E" modified="2024-05-29" version="1">MKRSHEEVSEDVFVYHENTDLSSIPTDITGLRIDDSVKKIPPDTFEGREQLVNVEYPEGLEVIGGQAFQNCTLLEEQHFPSTLVEIGPDAFNGCYEFKVVGSFPVNLQCEKLQSIEILTGASCLKSAFAACTSLTHARLPLGMVTISPLLFRYCNSLFDVNVPSSVIEIGVGAFDSCQSLALIELPIGLKLVGHRAFSRTGLKCFHFPSTVEAIGSDVLSDCEELESATLPSKLKAIPNEAFQACSALKNITIPISVVTIGIGAFVNSGLTHLDLSKCNLTKIERAALAFCSQLKTILLPRTNLEFIDEETFKGCSSLTHLRIPPTVDCIEGGAFADCTSLLSVEVPETLEDVTLIVYNEEEGYLGGYNPLVNFCLPPSEALGDLEDYNFMNDMKLREAANDCLDLVNKLEHRFDGLPLHRACYFQNYHTLEDNIDSIQNIVNADPAACSMWISVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4T7</accession>
    <name>A0AAD2G4T7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4T7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1962977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48628" checksum="234B20EDD6458868" modified="2024-05-29" version="1">MEDNEQDWVEKLVKKSLVYFKQRNFQKAKGILAKVLKIRTKEFGEDNVSVADTLFYIGMVLKEEGNFNEALAKLKSALEIQLKKLGESHIDTINTYEVIGRVFLRSGNSDKAQEMFRKVLDNRLESLPHSLFHLMDLSQDLVLAFRNEDNLSEAIKIQRLVLAKLLQFYGEDSSEVTRVYISIAMLLKDQSRLDDALQMLDKSIEICSRLQHQGGFDTMILAGALLNKAGCLEKQRNFEGAMEVYNRVLLIQKEALGEMHPSTAETYAYLADAYANQNMSEDAIKAYAKAINNRKANFGDGHPSTKKVSSSLRLLKREKKARSLYEQGLVMKAQEDLEKAIQFFHEALDIFKGVYDVHPNMAVIYENISAVKVEQSLLEDGIAASAQALKIRRRTLGDDNAYTKGRMEVHRSLLRRLLENRNHKQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4X4</accession>
    <name>A0AAD2G4X4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002022">
        <property type="protein sequence ID" value="CAJ1959787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4X4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="109" mass="12085" checksum="7F229CD4B1741CDD" modified="2024-05-29" version="1">MVAELGQYVHAIGTDSCNSMEPRSIKAIYIEPTKGQRTGHQVLNLNTKKMISRPKGVVLPVTDQVIQRVEAWAATKGVTSMMETFQDGDQIAGVDDREQGYLEEAFDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G501</accession>
    <name>A0AAD2G501_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G501"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="503" mass="57555" checksum="470FE9A14A2E094E" modified="2024-05-29" version="1">MTRKRDAFERPGDSVSPRKRHQKEQGEDYLVHLKYSDDVRVHNIVDFINRTVQKEWKFSVGHRDGAIVNHRADSEEGWILEAVSSDLAKKVCNLNGMYYKHQPLKIQKYGALTSPSKFCWNEYHYKRYGKNDHFVEHNILATILNSEAGGTDIDALKLQTMLNEKMEEFKLASTNTPIVKSIKIDSEDGNGKFLLSMRTERYASRLTYLNHINIGNHSIALTRLPEWKGEKPRYLNYDEFRKDHQHNELGSKPAAVEKAQAVTIVIEESKELEVAIAAQGSMKAIIAKQAANAKDLRSSLKIANDKLVQKDERIAQLEKVMEEQTQLLEDKCESMKTIIAKQTADAKKASNSLKLAKEKSAQKDERIAQLQTIVKKQKKDLEDERDKVSSKEEEVGILRQNLAFQKDEIEEQCRIVTSKEEETAKLNGNVERLSDELDSTVVKLDAVHQSWSDQVLMLEAKDKQIAIMNAKFEKLRGAFLWQPGMDAKEKAELQELKGGIYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5R3</accession>
    <name>A0AAD2G5R3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS20431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5R3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="58"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1964018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="614" mass="70983" checksum="0BEF4D740356A7B2" modified="2024-05-29" version="1">MLYSRRKHRPLVEERPTQDKYDRFEEWLRQNGAQFEYLELREYDSPTATENEEEKKEQPPTLNKSGDEESEIRGVHAKTHLPPHTVCMAIPRRCLITVEMGQETPIGQAILRSELDLDAPKHIFLMVYLLWDRKVNGEKSFYHPYYEILPPTLRNMPIFWNAEELEYLKGSYLLQQIEDRNEAIAEDYHAICQIAPLAQICTLDEFKWARMCVCSRNFGLQIDGHRTSALVPQADMLNHFRPRETKWTFDEDRQAFTITTLQPIPAGSQVYDSYGQKCNHRFLLNYGFAVEDNRELDGFCPNEVPLELALDTEDPTYAQRLDFWMRGEAGYSHLQVPPPHHSSSSSSFYPTPPHATSSMMAPGASLSQQQQQQHPYKQSPSYTKRVRICVSNNENTRLLFSLLRAMTCSAEELQAITSPVNSEMRSLFLGDSSRSSSGYYRSCRDIRHPLSLTNERAVMRKLLHIISQALAGYATSLSQDRKDLLDQRMYPPYSNVRHGKIQVRGEKEVLHHFARWARTAIQVIDVIEQDLKEEQQRGVEVQLGRGIVADDSSRSCGYDYIIRRMEEDEDGVHHTILRYCADVLGSVRREAFKSMRKKRGIISAATKRGESYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6K6</accession>
    <name>A0AAD2G6K6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6K6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="506" mass="56568" checksum="61CA7C4B79A03AE8" modified="2024-05-29" version="1">MGQGASTPKQRRKKKKSKKSNNNKTDNNNHDQDDLSLLKLEQKIALTKENLIRTKQLGGVNKRTQEDEIYYFEMELYKKKYILHKRGHDAKQYLSFWEYVEIVNTVLHADSTDYSVASGDMTLEQHKAAQEQEKEKRKAAAGTLAKHNGHFNVYSFFEAFLLRRLHIAMILKHQRAKQSDVWNDVIMSLYNIMPGMKKRNKAANEKLIVIKPESNETMREMIKLQKKKVKLYEHMVENLKAEIEEEEMANSLDPDDPLVVDADEPPPSTIGGEDEDVNTAKYYQNNGRRGLDDDEMSFKSFTSRKSSRSKRRTSKNPTAANGVEQAPRWKKSSRSKLSKASNRDVTNGGEALDSSYRSANSSRRRSPSPAYNSPMASPMKSPNQEPSPAAGGGGADGNDKAPITDDDIERFLYPNKPLRKSGGSSRRNIKNRGGEQSLLPPSELEFVDQDGGGRSIVSGLHDDSSVGSGSNAPQSLADIKAKKKELDGLIKAMETPGEEGESANSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6N0</accession>
    <name>A0AAD2G6N0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6N0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37879" checksum="EDCAA98157B09F43" modified="2024-05-29" version="1">MASTTTRTNPVDPFAIYTKRYNANNLSWASSTRGSLKGNPLPFQLEQEVDGTIRVCKVTTNFRQNTGIQEGFQLLQLQGKDVSDYPGGVDELRNIVQENLSIQVIALKPSSGTEDVATTTKTPSSTKTTVTNNEEDLVKCCKQRSTAANHCVELRSMPKKEDKKIQDPNVAEIRTKYKSRDLLWACSTRPSVRHTTPFRLTQYPSGAIRIVQVESYFQESTGVHGGQRVLQLQGKDIAAYDDFSEIQKVIQESLEINLVVLKKQSRPKRKQKQSPGGTSSSTTAGSKASNILSPIATRASSSKPSSQNKIEKKESSSNNKTPTSSHSSKRGSLQSKLKRIFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7M9</accession>
    <name>A0AAD2G7M9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7M9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="2">
        <location>
            <begin position="542"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="3">
        <location>
            <begin position="716"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="869" mass="98982" checksum="195113656DC81B3C" modified="2024-05-29" version="1">MQSDRGVLQDRLNKIQNAVRQAQQETWKHQNPASALPNIKSHSASFQLGLTLFRDDVERVDERIRDKLEDVEKELNKLSTETQPNDFISQDSEDSPMIMLPMSTIGEGEADQGDNSDEDLLLQNDPQALQDEIELHRTKIAFLKQASLARTAINDSKTLSNRFLSPNSMDLLKASKLLVQANELLRQAESFASSLPAHKYKEGEEMEDNNEEREEEYSQEPYQYGTNIITSLRNEVRLERSKLLVTAGTILDQSVQLSPNSIEVKNSKQLNEAYAILEQFDAELSNRIMRETLRRFTKQLYQELLKPILYEHHGKKWKIEEKEEKALSAKAGVTTKGPVHRIDWTIVHGDSAMDTLNENSSAITPWKHTLDVLGRILVFCQSRILMNRQDPCEYVGAFLFGDPDAMPSELNLHAMGLDSTRIGADKGMLSEPILELIAKESLPDHYDFMDEDIVTLEDIASELKSYVKPFCMAMCQKWFIPIQPKPKLIDFCDKLPQKYIEHRRCILLDKAKDILVNNDYHNTEQVGITELPEGVEEYMSIFFMQSCSVSVTALKIVELVRETMEEVVQAADAPASLQSLRPNLYKTAREMFTLYRAVIPSKFRKEVKTVPRTAAVMHNDAVFFSHTCAKLGLEYKGRFAKQEPIEEDEMGPIMEQTFVFVDIVPVFRELALECLGDMLDFQKKQMVELIQPRLGYFAMSLKSNESLLEWSEAETALAAATYHLKHLQQAWQNILPKDVFAAAMGVLANVVFEAFLKALLVQDLSISPTANQFLASLFGKALKDIGEFFQKSKETPSQCCDEWDRFVCIAKFLETHSLPELKDSLAMGVFLHLTSRDVKIMLVACHKHQAYHPDYIALMNELANFGSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G911</accession>
    <name>A0AAD2G911_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G911"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042125411" description="ShKT domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="391" mass="43593" checksum="9B70870354091AC9" modified="2024-05-29" version="1">MSSSKHRRSFLLLLLVVQLVAHANALEAEERDFPVELDEDTEYGETDGDLLEQEYADDQDLHDTGLYVSIHEADEDGEESSAAEEDWFIAGNHPRCRDDPFINCEEVEESGDCSPEKTGILPTSRRNLCSVTCGLCEVREDAVWLEYNCFEYGEDLHVFFHNSKPSVEDYVGIYPAAYDFSKHPELLFEAPLWLTTCGSLDDGCKAAKGGLLFGELGPSDEIAWNFFPLSAGDYKAVLARGNETIEVISESETFRANPLGRSCNNDCEDLIRTDVQCYNSGIDTIQITFENCDPHEEDLIAIYKDDETPGDIEPLLWLGTCGTQECVGEVAYDILLFGPRSPDETARTTWPLPDGDYKAYLLHYTPGANHGIPAAETSFIVRKQCDESSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9Z6</accession>
    <name>A0AAD2G9Z6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS22113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002295">
        <property type="protein sequence ID" value="CAJ1966530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9Z6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1100"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1966530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1271" mass="138585" checksum="25F018DCC725044F" modified="2024-05-29" version="1">MSTSSSSASINALLKKTEHYDKDERYMATSDLCEVLKRHSSGDSLSVLSDSSTERRICTAVLRLLHDKSNDVQAIAVKTLGVLLTTVKEEQVLEIADSLTDQVLDASKSELRDVYAIGLRTLVKTIPPSMGDLTSKRLVGRLLDGIRTSQNEEIVLACLDILTDLLGRFGASAVSVTRQHEPILQMCLQQLVGPSLVVRKRAGNTIGCLSVVLSDALLGSMVERLLSQIDSAAGNPDDTRALIRTMCTVSGAVGHRLQQPQIDRILPIFLKFTNPHNAMTGDDEDDMSPSVDYDMQDEAAVAVANELKESCFMGFASFVTRCPTQVEPHLEKIIEASLAYMSYDPNYSYGDDDEDAGEDESGEYDDESGDDEYEDEDSEDDDDDDESWKVRRSAIRTLKAVVEAKRHSPAALWTVTYKTRQGQAASVAMALVTRFKEREENCRSDVLDCFTKLLSVTVDAAKAGFVTLASDDMDTGSVTSIDLRTKYAPSLVKGCEKLLGVKKGGGERSKSNALVLLSTLCKAPGGIGGEHAIISVFQHIRSFLADSDSHTLHRETSSKTLRLDALSLVFAMLSCGNHDPVHIRKGLTQILLPPLCEAVKEQWYKVIAQALRALAAAPQFFVDGFNSNEQSEEEKLEEMNEVANKIFLAIKPLLAVHDVDQEIKECALEACACLLGSLHSNLSVEQKNALLGLVLERLKNETTRISAIKTLSSICDTNPASTQGKIDLSSMLRESIETMAGFLKLQSRSLKQSSLEALDTMIKNHGAGDDKALYSRVLEDLAHLIADSDLHISHLSLRVSHSVLKICPGCGPAVKGFVLPQALALSTSPLLQDLALESLLALLQQVVVSEAVDFEELMGMLRGRLDEASPSKHAIYNLGRCIAIITASTTEVHRQKLIAETLTLLEGSKTPSDRVALKKVQLAILVSGDLGRAMDLSSIPGVADALPAIYMGYFDSGSEDLKHSAAYSLGRATVQAQSTFLPAVVEALEKNGEKKQYLLLSALREFIQCSDGQKGGAGVNASLQVILPHLEKHSSDDEEGIRTMVAECFGSLACMQPSPILKLLAQIAHNHSAITTKDGTVDGVDTASQKNALVVGDLMKESIMPSLYKVAELKMERKVDLGPFTHKVDDALPLRKAALSIFATCLEKLPGTLDMNAFMPVLAKALSDVEDIQLQAHQIVISMCVRQPTHITSSVESFVDPLEKTMHKKPGQKTGTELERLNEWIKSAIRTMTAMGRVQGTMNSRKFAEFYERTKANSKFRAIFDALDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAK1</accession>
    <name>A0AAD2GAK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1995 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018962">
        <property type="entry name" value="DUF1995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09353">
        <property type="entry name" value="DUF1995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1995" evidence="3">
        <location>
            <begin position="111"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="442" mass="49202" checksum="74BCC4E912DE639A" modified="2024-05-29" version="1">MVSSDRDESKENDQLSKLERKFKQRISRLEEIVAKQEIELHRLRKTCHELSETAEAFATVVKLLKESGIKDKSGAKKGDQNVTPEKKKLLSPITGTFVESYDESVIFGSAPSSVIDAADAAGSAILAGMLAGKKRMLVDVRDAELSTDLETLVQFIELAILPVAAGLEGLESQRNRVKIVFPKVSQLLEYRKTMALAAPEVVALSTLGFDPVEDSDQLVVIVAPAPDDDEGIKAMQELLAQKEKDGKETIQQTVVILNYHMFPVPSLPVKFLTAYHLRLLRVQFMSRGLADELQQNRQNGPEQKEDLEEVSNDKSPDDVEASKKEDEELEAAMQHAHEVGMNQGITRAMVIRAYPRPWHLFVDTSPGTDADFEVAGTFVEEPTMEEINFSIVECLEGSEREDEIVAKQMQEALDEGQLDAVEGMIDDLEKVEEDDNDEMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCK7</accession>
    <name>A0AAD2GCK7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002407">
        <property type="protein sequence ID" value="CAJ1968814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="619" mass="70622" checksum="6F65F122DCDD0E8E" modified="2024-05-29" version="1">MHSTRVILGRGAISTHHGQKRILKHSTPDLVTYIRKAVQTGIYRSNEEIEEMNQHLKDDPTDLKRIRWHVPRGSKIHDYPAEYEILSLNPPSPFKPFMPKKDVRKAVNKYMHEHRPTDRLANNYLNRILRGGNTGEPGTAEEYYRRLLGSSKAPKVDSAMGSKSAMLNKAYAVAVKQYQLMRTEDLGEKEALYRVEELLKQSDYEEKTRSRLRAKSLDKHNLSDEHAEKRAQAAYPAATPFADQKENMDTSMLYSDNQRSFEGMISWTHRLQAVPYRQWTVGASTALDHWIAKRVLGMSEETWLELLEGDSPHLIGRGRDIVVARHALFPETALDEDDSITRIEDDVDIVEDDLDALLATLGGWNDDADSATEVFSSTDEQILGFTKQLQVWRTKQAESPFEAWSEAEKSEFNTWLKEYVTALAPDSDMLEVNMGGTRNALLLAPPLSHDDSTAFWENIRDETAAEVFLQLLHSQKTTSSHPFWQLEYDLQLERLVELGSIHEIADEYAKESDRSLFLSRYGDYLLEGLELDHLAPDATGPIRGSDLGDALMKKYKIAPSDRFHLKSIKYGTDEFGTPASQRARDIFRSWNTLKTGRAHYEEKLFQKGLLGLSYSKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCX1</accession>
    <name>A0AAD2GCX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002442">
        <property type="protein sequence ID" value="CAJ1969975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1969975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="84" mass="9103" checksum="E76ACDB083956117" modified="2024-05-29" version="1">MNFSNHFISSTIQYSLKQLSDCRHGFLGLGHNVGAIFLIVNPADERCHAVILGPLILAKSFRTVTAANGSPILLALFPSCSNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD48</accession>
    <name>A0AAD2GD48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS23058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1968042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD48"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053038">
        <property type="entry name" value="RLP_Defense"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48064">
        <property type="entry name" value="OS01G0750400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48064:SF6">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1968042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="76167" checksum="96DA498D65BAA213" modified="2024-05-29" version="1">MKQSSTRNSESAPINLVDHHEDPLSQSSSHSPPREEFVDEEQGLRTGHTKDLELEQGKVVASEEQVQAMIQNVSQMAKNEKPDPIIRPDGRRRSSSDRRSESRRSSSRPKDPNLPRSSSPRRSASGRPSASRSRSRRESSAKRESSSGRTSSERRSSSERRHSSHRKRSSSRKGGDRDRGSRSRSRHGQHHRHRSSRHKKEEGNKIVDEVPKIPEKQPPRKKNYGMFVFLMMLLIIPAMIFVYFFLFAPNDDSKEPVKLLITNSPTLAPTIETARPTQAPTEPGATPIPSLSPSMVPTPSPSDNMEGPISEFFTANNVDYNNTAVKKAVDWLIDEAYFANSLAFPLDEKYLQRFGILALYFSIFQDPTQATLAPAQPDLDTDPDVPDLVADIQQFGEITLPNWGMRTQDHCFWRGMVCNEDGMIIEIRLSNRQLTGTLPKELGLFPSLRYIDFSNNQLQGSIPEELYDNMELEHMYLYKNSLSGTISSKIGNLWNLTHVHLSHNQISGPIPNRMASRAKIRQIRYFNVHRNQMTGTIPANMRLRQMFYMDLGANQFSGPLPPELGSEYVRLRHLFLDHNQFTGTMPQSYIVAGNGRIRTLEVNDNQLRGAFPGNHQSYTELMQLTLHNNNFDSMDKDTCKLEVFVGGELVEFKSQCSICRCGGDSLMCRFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDK5</accession>
    <name>A0AAD2GDK5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS23884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002425">
        <property type="protein sequence ID" value="CAJ1969782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDK5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042282545" description="GOST seven transmembrane domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="9">
        <location>
            <begin position="253"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1969782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="571" mass="63832" checksum="0D4E85797BC82A49" modified="2024-05-29" version="1">MTIIKSQSWAPLLLCFVGLVLATAVVTAPPQATIKALEEQQIYLPATPTYVTAVVEFFSQPTQLNISHIEFKTISRQDYCQDDSSKNKYCDVSNTVMETSVPRYLHLVLLYQPPGCIKDSTAQMCDWTHLGVGSSNNNNPESKDDVCCTLKKQQAGQCQNLSRLILNPDKLIGQEQSLLVPSKVNKRFALGDHHRQQGHHQNQEQQQGLFDIPTAGEYAFLMANCNENGWDLLSLPRIIVKPTPSYLEGLIDYYASLTFYHFALCLTYVFAIVMAIQDKVLPIQKWLVATMAVAAFDILFKCIDYKYYWDAEPNDSWFNIYTLSVTMSVLKRGFSICIGVMVAKGWGMVCTSLGGSALAIAIFGFLYTGIVFVHDISNAIGEANLENESREQGADLTATEGTLGFVIFFMDIVFAIWILVSIRVTIVHLKSVGRYDQMPHHRILGCLLAVFMLAIAPAWIIQFVDKFEKSPTLTEEQWNYMNATVQGIYTITLTGIASLWIPKRKASNSQQEEAMEMKELNNVTDAYSDNLAPTGEEEDDEDEAIRPIDLDNDGNDPDYPNGLAVENGHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GEC4</accession>
    <name>A0AAD2GEC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS23838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GEC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1969684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="582" mass="64505" checksum="9744AF155B48FE19" modified="2024-05-29" version="1">MRLDLSFFVFCCKSFLGDDESETNYYDLLGVERDASAEDVKKAYKRKSLQMHPDKLAQRGQTVTDELQAEFTKMKEAYEVLSDPHKRETYDAIGARGMKWIDEPFSIDPQDLATNFSKSSVVDRAKIFAIFVAVAVAILLLPIFICLHLDGSFGENASWFATFIPLWIWDGFLVFYHVRLIMMGPIERPEHIPEEEWSDPLPMPKRYMSFFRFGLLTLFEIFATLKLDDSFGGSWLMAFLPYYLWELMSVYKKWPMTKMKIVTIADLEAALGKSTAEFTEEEKEAVKEGYAVVSSLEGEDFQEAIRAKSAARQELVKSAFRFIFSLFLLLQLGGSFTLSWWLVFLPVWVISVLVCLNNYQTFAEVQKKAAEKDPTLFGIEGDPLNTSTDYGAVGVDGTATPDAAGGGASPPTPLTEDERENLKAEVMVHASNLCTKCCSQGFVLVLVCLFVAKLQGATFSSFWIISPFLLVAGIILCCLGFAIFGISEQPEDAELFNTTAAFGGETEPDTAANSPTIIPTDYAPPSTNKPEVDIELGGGSNNTTPTTDLDADNKTAESSAATPVDLLDTVPSKEQTDMGDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GEM7</accession>
    <name>A0AAD2GEM7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002524">
        <property type="protein sequence ID" value="CAJ1970505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GEM7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="187" mass="20973" checksum="320C465EDB26155C" modified="2024-05-29" version="1">MHKKSQPRQVRRAKKKGRLWRPLPIWYGILIPRTVKEALALDDDNGNHFWHEAMEQEIASLIAMNCFDFHSSNYKPGPNSQFAPLRMIFEAMQDGRRKVRLVCGGHLVDPRGISTRSTVVKGVSVHLLDMIANHYGLTIVHGDVGNAFITANCLEGIHLDLSLESAKALLLLLTKPSMGSKLVLQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGG0</accession>
    <name>A0AAD2JGG0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042255731" evidence="2">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="271" mass="28468" checksum="865AF89777AE41D5" modified="2024-05-29" version="1">MKLFIATLFSFVVVGTVNGASHTAGGKANGSVCALDTECESAFCSVDLTCKDKQVSGETCIENDDCVGGYCSGTKKCLDTKLANGSGCAADNDCESTFCAVDFTCKAKKEVGEACAEDDDCTTAFCSVDFTCKEKQVDGEVCIENDDCQGGYCSGTKKCLDTKNADGSGCAVDNDCASLFCSVDFTCKAKREVGESCVQDDDCTTAFCSVDFSCKEKLGINQTCIEDDDCQSGSCAQLSGFKCVESSGGLAWNLTFTLLFGIFASFLLIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHB3</accession>
    <name>A0AAD2JHB3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase/fosfomycin resistance/dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHB3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06587">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993:SF14">
        <property type="entry name" value="GB|AAF24581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase/fosfomycin resistance/dioxygenase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="122" mass="13176" checksum="4F0510D496A85D95" modified="2024-05-29" version="1">MIPRLSRVVLMVRQGEALAKATEFYHSGLGLEVVRATDDFAELQTENLAVSLQGVTSESKLSTGYSPLLTFEVKDMDSIVATCCQLGGHLDGPIQYPAYGKIAAMRAPCGHMIGIFEPVTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHE8</accession>
    <name>A0AAD2JHE8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="251" mass="28876" checksum="61C3A403A9922EB1" modified="2024-05-29" version="1">MVSSTTTNKKKTPPRLSAEDYMIRSKALDLLQTVDHQIVYENDYDDDDGDNSDFSWITPEEQPISYQHSSAVPVIERKQQQRHPARIMGASQDQWIDIFVPAVSCISNACKLGVSSMVKQTKDGFHVIQNDLRERRLDRANVKKKKDPSSHRPQRNIRRNDSFHRQRAGYPEILETRRGTAGQQTAERYSARGYVEDEDILCYHPGEWRPQGLLFVPGEDLRQHQYDDVSLMTAEDHNDSTKKCLGFCPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ33</accession>
    <name>A0AAD2JJ33_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="400" mass="42827" checksum="BED9C03AF545AC9F" modified="2024-05-29" version="1">MSEAADARAAAAESRKSRLQILRERQKKLRESYKVQIDMSRRNLDGDESGGRLSPMPAVSEAKDSAATEPAKTADPGAKPEGAVDSTAAPVTPSTAVRPTIPTTPNTARLVQTQTENEELKRQIVALKADRELLLERQMERFASASEQLNEMEILLEDYRSIAEEAEENNAVLKAQLSLMTSEQANWKKAESELKDRVQQQQDRLDSSVQAMNDLEKALNKAQDDLQMSDQHKMNLEHQLRSVASTNAQIFQGQVHGGATYFPPPQQTVYYPVPGDGGAGRGSNRLPKKPFVGGGGPGMPPQRRGSHNTGPGGGGPPQRRGSYNKQGGNNPGGGPHFAGNVAGGPPSSFHPNAGIGAAGGGLPNFNPSAPNFNPNAANFTPQSPNPGGDYNNQGSKKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJN4</accession>
    <name>A0AAD2JJN4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJN4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="166" mass="19439" checksum="194900B71A10DD16" modified="2024-05-29" version="1">MRRHRTSSSIDENDTNSTCKHQKKDPIVSPASFQEFRQFTVHEYPNLSFLGPTSMAVYWFRTYLKEDWIRCNVVSEAPPRRRRNNKTKHRRKKGGNFLHIPKAYTTTGLNEKLTIQDILHIGTAGKHYANSYIGLYNMIRQYGIFSRSDNWQVHMTGYNCPDLPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKA0</accession>
    <name>A0AAD2JKA0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS17587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1959164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="19759" checksum="CC2269A80DF4AC8A" modified="2024-05-29" version="1">MSVTIHTTNGDIKAEIFCDTCPRTAFNFLALAAAGKYNGTVFHRNIKGFMIQGGDTAHVTGKKSSIWGDDVTFPDEFHKDNQHDRRGRLSMANRGPNTNKSQFFILYEPQPHLNNMHAVFGQVLDGWDTLDKWERMPNAHKTTPVDPPEITSITIHANPLADEGITYPTPDGPPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLN3</accession>
    <name>A0AAD2JLN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1962125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLN3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="219" mass="24812" checksum="E86B3540888F95E5" modified="2024-05-29" version="1">MKVSQQKQQQQQQQQQQQQERGKSSLFDSVTFIVLLFGLPVPFVFLVTALHQFTMMWSYCPFCLVFGAYGILVTSFVEAATKVIRWTSNTIVSKHDSEGTLMTPLVFVLFPQWILFLYTILNSLDCDAMNLQATTTTTSSPNGEIDAGTIALSALMTIGIPLMILIRAFRQAWKDIDEEDQRQKLNRNKTVEPARKIIALSRNVHSKRFNGVTSCLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMN0</accession>
    <name>A0AAD2JMN0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002194">
        <property type="protein sequence ID" value="CAJ1964666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="25220" checksum="305E5E074F90EAB5" modified="2024-05-29" version="1">MTGPSTGRDATAGTTAKKKRKPRETVVPPQMSTRSKSKQKTQINQSPGASLVDWYKKRNSLQPDAEKFVSKLKSKYFTIEGNDSYLNWQVFGGFAGACFNAPPSNVCFLNGLLDQGPNKIGPAANGLLDEGPKKISPVEKGAPAATIMREEGAPLDYWKPSSPTRRRRDIDNGEQSWAQQLRMKRELQPFMAGKESEEVGENFNEFLTGLDKMLQPKAHEEEAVQSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN15</accession>
    <name>A0AAD2JN15_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN15"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="2">
        <location>
            <begin position="63"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="153" mass="17183" checksum="45E76715275CA6AB" modified="2024-05-29" version="1">MSLLPFHPFASFFDEALHDSLFFSGNRNNTQYLSSSSNHHNNDKNKNAAFCLDQPLGVRLQHQSDKAFVYVIDAPGIQPGKWRLNLEKKKQETIIRLSVGQQPIKGSSASEDDESSSERRLFSVGSKVDAERISGNLSDHILTITVPKKKQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN46</accession>
    <name>A0AAD2JN46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="343" mass="38633" checksum="9F5D34B44B0E3561" modified="2024-05-29" version="1">MEMSSTAEPARKRRKPNEAEKNMSFMINHHAAVAATVTPIKTPKASNSTASEADIDEDTITHLTFENEDATRHNERNKANDEGKQEEIDKLVVVTQLIENLRFAMSFEAAEKAIDMLFQELHTEDANVSTYDPRKTTTAFHNPDHISLPVAKVITRSNGVLTIFVALQEFQHSGSNMFLCKTLRLLSLISSEVPAAGQQLIESGAVRSLLMLARKGAHVDCLKLHKYDQIKRNFDYSLKSNVVGILADLVFGLGWNICKQVVPEETLDFVISVIKEYPEDEFMQHVGIEYLLCVGKTGDSETSTMLQKKKVGHLFLEALDNFRHESVEVKEMAREAMVWYFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNP5</accession>
    <name>A0AAD2JNP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS22755</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000009">
        <property type="entry name" value="Oligopeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF83">
        <property type="entry name" value="LD37516P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042292301" description="oligopeptidase A" evidence="11">
        <location>
            <begin position="21"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Oligopeptidase A N-terminal" evidence="13">
        <location>
            <begin position="304"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="12">
        <location>
            <begin position="554"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1967398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1070" mass="120847" checksum="7ACBEFF7CB791B20" modified="2024-05-29" version="1">MNFKLILFLLVECTRIHTDALSFPDPSLPGSRRGPYSDYSNRPPSYNDVPTPYNDGYDLPPRYNGVYDMPPYYNGMQPFNYNDGQGMTPAYSNGLDTQPSYDSQAGIQPSSNRQIAAIPLSADVPLSDMTAYSNGLDTRAQPSYNSRAGMQSSSNSQIAAIPLSADVPLSDMTAYRNGIDTQPSYNCQAGIVDSSSTSQVPAIPLSDMTAAKADTNGVDVASRTDFFATHLSPMDNNPLLHQENCLPKFSRIRAQHIAPALEKKIETMKLEFELFESYLNMKASSVAPNTGIMNSKDDSEKLELSCMLDQLDSIKHILDHTWTIVSHLHAVKNDNDLRKTYEQYQRVVLKASSQFYQSEALFDALQKQLEEQVKSNEKQQKELSNNIKENRAITPVDSIITDKVYEQQQEQRALESILRSMKEGGVGMKSKEDQDRFNEIQLRLASLATKFSHNILDETQALFMTISDQSLMDGVPESILLQWNNAYRKEMARLGYIGISDTRNPNDSTSFNGWSSNGPVSYEEQQYEEEMRNLGWKTGPWRVTMDQSSYLSAMKHIRDRPLRQQIYMAHLQRASEKSPDKNNIPVIEEILQLRKEMAKLLGYDSYAELSLSSKMASSTDAITKLSDFVLAKALPAAKKELEEVTKFAHASGGLMETDASGCRVPVPLEPWDISYWTERLKESKFDLTEEELRPYFAHPNVIHGLFQLVNRLFDVTIKEDVADKWHPDVSFYNLYDNASGKHIASFYLDPYFRPLNKRGGAWMSSCVAKSRALRNDLPVAYVSYNVHPPAERQQQQQGGRPSLLTFREVETVFHEFGHALQHLLTTASVGEVSGINGIEWDAVEIPSQFMERWCYDRDTLYSFARHWQSHQPLPEAMYEKLLQQKVFGAGMKTCKQLYYGQLDLALHGTTSAISTFDENDETIQSQYFLKQPKTTIFDVQRKVAEKYLPPSMMPLLKEDRYLCSFSHIFAGGYSAGYYSYLWADLMSADAFGAFEAVLNDSPSTTGTQGTNNNNNNNNNNKEDELKVIGKRFRDTFLSLGGGIPPDQVFEIFRGRTPTATAFLEQSGLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNV2</accession>
    <name>A0AAD2JNV2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNV2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031610">
        <property type="entry name" value="TIC110"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34935">
        <property type="entry name" value="PROTEIN TIC110, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34935:SF3">
        <property type="entry name" value="PROTEIN TIC110, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041943072" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1103" mass="122393" checksum="2DBAE4D8BE9271BF" modified="2024-05-29" version="1">MKFTSLTVVALLLAENKNGDAFTVKQPMSVSQIHQNPRSTLQPLKFAEISGGMEELQEYTDAKTVSPLEKQIRKSPSFWKLAGYATVPVSAALGFGLVPSRRLAAHAAGALVTGVAGAIGKSKLDSVSEVVTPPAIAQAILDHGLDDPLTTAGYVKEVQEVFGIVDDEEFECMCSDVYSKYFLGMVKFNPIAKTSELKELTKLRQALSLSNLQVGEAHSAAAAEWFRQTCIFTPEEDLDDPDHPDRQAMDKLLFLTERALTQGGETPEAFQFEMTRVAKAMKLTLSEAMDRVADVQEPFYARALKSTRTKLGTNSVSGSTLERARETLGIDEQTAFDMHVAAFNEEVKELLGLGEDDEVVELNSAKFSEGTQARLDQLAEVLGLTPKDAAYEIAAEATPLYQVTALEAIQGVLDGLRTPDGAWEQMEVRREELLLPEAKSKDLLSSMVMQALGGPLEQTNKFAKVNNEVAVYDNLLEALEAKQALLAILEKSGWNEFENFDKTFCDPWDKHSANGFLRPDERIKIYKIFSSRSLRNSEDGKISEEMFARMAEVKGLLGISDDQAEVESRATFGPELQKVCVRALNEITADYTPELAKNMKKAINDEVEAYKLTDDFLREQGASYYAKAVSIISEKSPSGIPTKEMNEALESLREMYRLEKEDTYPSHMEYFGAVYRKSIVEAMGSTGVIRPELKDALNDLRDRLGVREEDTKQLFLEAVEEKMVPMVEWINSEMERTMLSQEQLAKRRGKDMGQDMFQSGKAADGVLGVGAEVQIMSDIMNLVDFYNENEIAEEKEIGTEEVDGETVPVLETSYPITALGSEAIDQEMAETLYRQFVVGAFTNQGEQASRYETSRATFGGILGLTSEKMEDINSNIGSTVYDNFVSRSMAQKGALDQQDMMFLANIQGKIGLSAEQGEKLLMQSQKKVLSEEINTIMDDPTPERVKAFREKCNVMGMDLAEDVGISKPRLIRMFESEIIPGLKSGEITAETSEILTEIQESLNLEAEECEEMFEATIVRLSKQALGLTTSELLRGRYDNAVDPIKEIVLYASFVDGDLGLEAPEEAEAYQIFNIYESLDFSEIDNETVEENKRLLKAALGLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNV3</accession>
    <name>A0AAD2JNV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1967998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="187"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="262"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="339" mass="38066" checksum="0DA62CB0544BA482" modified="2024-05-29" version="1">MMESIAMQRRQTATTGGGALAALAELCDCKEYGNPPSLSHGRPPMNSKLVFPKLFNSNTRPSIIRVVAPRFPGATLTEPTPVSPLRNSLLNQQRNMVGDVLSASLSLAELSQSPVVFRGDGSILAEKAPSASSSDSVSSKSATSSTSIKPRTKQTRCLSKPVVGTEATATPPTQGNGNVRFRQYQVTTWSQRLEEVQAFVRQHGHCMIPSDYPPNQKLAKWAKRQRCQYQLFQSNPTKSSMTAERIRVLEDFGFCWQNKMSVWQSRYEELLQFHLQFGHTQVPSSYKPNQRLATWVKCQRRQKRLRDRGKPSSMTGDRIALLDSVNFVWRMYPSNPRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPU2</accession>
    <name>A0AAD2JPU2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS24424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002513">
        <property type="protein sequence ID" value="CAJ1970406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPU2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="487"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1970406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="969" mass="104497" checksum="E4EAD2ACF9151329" modified="2024-05-29" version="1">MPERASSRREKSRSSRKSSGRSKNREADEDPSESSHASNHELSERSGGKARERRSRSGRRSTAKSEEASRDTADAKKKRRSGPRATKPGAISANTNANSVDRRKERSATKTSKPGAVPEKATRSSDLRKKERSSRSRSSKPGDTPAKASRNSDDRKKERRSTRASNPGAVSEDVMTNRERRKEERAASSSNQTTAPYVAENMLEASTVDDTTEGDAIEQITRKFEQQEQKRQQEIEELNQRLANKKAEEEANVAAARKQRKKRIIITVLCFVALIAAGVGAFFALYKGTTSVTQILVTPQYDPPSEAECRAITRNETIAGQADLENADLDMSFDVTIDSGCDISTPQVQILLMAIQEKLLPPLIGCSSETDSRRGLVPDNEQPELVIGENRFVILNAYVTGRVDPDVVCGNTQDDSKPFHRISVKVILTLKGPVEESDLILLTFDQVDELLNEGGRDDDNLKDPFGLDVSFSEVRLVKIEDQYVSTASSASPSAAPSSSPIRTTSQAPSSSPPRATSSAPSTRPTLAPVVDSTPPPTARIQTPEPSMRPTLAPVVGPTPPPTASPTARPSDTPSLRPSTTPSLSPTLAPVVGPTLLPSSTPSNVPSRVPSLSPSVLASEGPSANPSIGASIAPSANPSIEPSMSPSSNPSMKPSMAASTFPSMKPSMIPSTAPSTKPSQSLTVSQQCFQSNSELSSQVDNWFGTALQKTTVENTYGPIGDWCFGAGVTSMSGLFSFRYTFNEDISNWDVSSVSDMSKIFWGVGPFNQDLSSWDVSSVTDMSFMFDGASNFNQDLSGWDVSSVTDMSYMLSRATPFDQDLSSWDVSSVTDMSFMFYEASSFNHDISSWDVSSVRDMSSMFSSATAFNHDLSSWDVSSVTGMSSMFELAEAFNQDLSSWDISSVTDTSFMFAAATSFNQDLCAWGSSLPSNANVFFMFLGCAGESGCPSLFDPDLGATPPGPFCHICVPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVR8</accession>
    <name>A0AAD2PVR8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001926">
        <property type="protein sequence ID" value="CAJ1956949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47101" checksum="6AB1D2F5622A8B88" modified="2024-05-29" version="1">MIANKKTAATPTSSSDLEELPTELLLQIANSMLNPAERTRLSSCSQRLQKLLPQYLRVKILCSRDDDGGAIQQDLFVSCAKSSSFDQFLTSSENLRYGQEYYFWSFDYQRGNKAFLGRHTRHAHEPSDANHHSDGGGRLQYLYTIGLRPCTPNQTWKVVGGTDGDMVMWGEEIALTVGGLNPKPRQPDSNQRGTLCCMPKMANGPVWIVLDSHHNTSGDSGSGSCGSDDTNNSIRGGESSKLKLMPCNQYSPSPKTPEKELIVHAIPRVCDEGEYLLHSPCSTMHGSIHSDGFHVIVDFTFWIHKGIMYFGSPVLPFSLGIPILETDILDNGACPLANLLNIKSARWGCVIYYMAVAADVGEGKNLNMQRFLQRVTEHRDHQVIVNESKDLVYINVLHKRVKTMADPIPRNDDALWRFILSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW20</accession>
    <name>A0AAD2PW20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytidine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40114" checksum="37AD2FFC39A105DE" modified="2024-05-29" version="1">MVSTEDRKDILLVNRYRLSLSKPPQSFFRVVALLFYEEVNEKLKQSSKLPPWVPQRTDDGRSYIVGTNDEPGFMGGSICAERSTIVQLRFLPSARVTKLVICTDSTEPIAPGMLCREFMAGHDCIPWDLRIISTGCKCTQCDKRDGDLFMDDGIKEGCVDGIPILDTTLRALYPYPSPYTRCNSSQSVSFGETYSQSTSSILLTESKSDPWKQLLKMATKEASANISENHPIQFGAAVSFADGTFATSRQISALEYGCSLDAVSQLAPHFRGKEPHLLVQVDQYGVAHSPFAPARAFLSENENYKDCKILVHTTGASANAEDAANLASWSLTIISVSDLAPNAPDWTSSTPEREHIKKKIRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW97</accession>
    <name>A0AAD2PW97_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002019">
        <property type="protein sequence ID" value="CAJ1959765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW97"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="103" mass="11664" checksum="9D5C7A505EF01007" modified="2024-05-29" version="1">MAVSKVLRIPTNDEFGLTEAFWELTGVHDEMSEVLASHSFLGAHREADSKTTTNNFTEQVLRLRPKFKTKKAEMQGIVRKTDEVNGYLDDIVRVPPSDGEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX22</accession>
    <name>A0AAD2PX22_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="414" mass="45570" checksum="512BF6EB131867B5" modified="2024-05-29" version="1">MSYQANQYKKGWDTGVIKKGGLASRLAAFEQISKPKGDTSEVRGGITNPAILERIRAAKAAAAAGNVTTPKTPLKNWDNKVKGMPPSIPAENDEKENKPEAEKPAEEPAATEQTPAEEETEAKPEETTVGRLPVEEKPKEETEEEAKLRAEKEAKEKEEAEQKAKAKAEEDAKAKAESEAKAKEEAEAKAKADAEAKVKAEEDAKKSKAATKIQAIVRSMLARATVMKMIEQMIEDLANKKVQNEKKFEEDKKKWEEEQARRQVKVEEERRASRQSLVVAKTDINVEGWGWGFVGPLQLPVARVPHWWMDESPHKTLFSEDFEEKEEEHWKHRQSHLEQLKKEGGGGKAPPKATAPAPVSAPAPAPAPAPPKTSVPEIPDDVADSGTVEISDSEPEVYISDDSVSIDEQLQAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXK1</accession>
    <name>A0AAD2PXK1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="353" mass="38834" checksum="8D9A76E459FF2819" modified="2024-05-29" version="1">MNKKNANQNEVNDDENDSSATLVQTPITGQHTAAAAHLDLGNIIAQNPDIMRLFQPSASSLQFGAYLTGLQSQGINQQMRVNSFLPSVIAAARTQQMHQLQQLLSLPPTQNPTTPSNNFSMGVASRQALWPTSALAQATEAQHLQYQQGNNLLASLSANMGNAVGTATSLSRAVPDVGNLPPTKNGQSPIVMYMDCDDESLSEYQCLLRKQIELFEANFDDVQWNAQGRNKAIEQGQVGIRCRHCTRLESWERARGAVYYSATLDGLYQAAQNMAKNHLCKHCKLIPLNTKNQLLQFRDCKRRASGGKTYWAEGARVLGVYETSTGLRFRNSEVKQQYQWTGGSDTQGRGTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBH5</accession>
    <name>A0AAD2CBH5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4116 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025197">
        <property type="entry name" value="DUF4116"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13475">
        <property type="entry name" value="DUF4116"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4116" evidence="1">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4116" evidence="1">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4116" evidence="1">
        <location>
            <begin position="433"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1923486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="698" mass="81059" checksum="43F0DD61B3C838BD" modified="2024-05-29" version="1">MAATLATISSHTVGAFNSLSPSLKELEQFEERGRRILECEIKVRHWKEKLACLMKEQERYYRLARLRRSAELEWLQLSHVEKMKKENIIAAFQSDKIPAGLHRFVEDDFPLHIRSDREIFLARVRRKDFGYFDTLRYSIRSLIPPALHGDKEVMLECVQRNARAVECLTDDLKDDKDMFRAVLKTSPLAPKFLLLFSEEVRSDPVLVLQLFHHPDVSPSHGKPKTQVMRYASQRLRGDYDFVLQCVQKSGLNLRHASDNLRRDPRIVAAACAENREAIAHCLPEAIVDGMWEHIDIAKAVVTQPDLDLAMKCMERYNGNHEILSLALFHLEIEWDMLPEELQSNVDFILRAIKLQPEKVWYSLSKEMRDELRVGSEMLKNKSCTEEMIWDVIEECPDVLFSRECVKAFLMNHSHLTSALEYISGITDVNIWNDREMMLVAISQNHWHWDGCSEVLRQDRDFMLELAEKCPSVFVCVEDEYQMQHPEMVIRALQKHPEYLKERFDDFCPELWENRKVVMAWLEIGGGWSEHFFPEEFSNDEELILMAIQHQLEDIGMASDELLEDELFISKALAVNASIIERVNPILIWEEDLLMVAISKDAHCIGYFLEEFEDTGTLVSFAQKVRHKLREYWTFHNDVLPSMRASSKEQNDCFLPMLNQGPATLATYIDKISSYVGMMDEGEIPTYIAASNHLASWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDB3</accession>
    <name>A0AAD2CDB3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000069">
        <property type="protein sequence ID" value="CAJ1929101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDB3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="656" mass="72882" checksum="627BB5DAD5A184F4" modified="2024-05-29" version="1">MSRKRSHEDVSEDIFVYYENTDLSSIPTKVTSLRIHSSVKTIPPYAFRGRGNLVNVEYPEGLQVIGESAFCSCQSLREQQFPSTLVEIGPEAFNDCYELEVVGSFPLNLKLIGQCAFFQCTNLRSIEILSGACNLQKSVFSACYRLTHVRLPQGLVIIPKCLFHGCKSLVDVQLPSSLIEIGGAAFKLCRLLATIELPIGLKIIGSGAFTITGFKTFHFPSTVETIGEGVLSDCKELESVTLPPKLVTIPNEIFKGCRKLKDVCLPKSVAHVGNSAFENSALTNLDFSQCNLTSIGDCAFESCRLTDLDLSQCNLTSIGRRAFAGCRRLKKILLPRTSLKTIEVGTFQECILLTHLWIPPTVECIKTGAFGKCSSLLSVELPESLNRVGFVGQYLSISGYNSLVNFWLPTSHELENARRHYFMENLKLGEASNGYEDLVSKLKQRFDCLPLHRACYFQSYHTLQDNIDSIQGIVKADPDACSKVDFAGMTPFHVLGLSQMPCPHMFQLLLSVVPSVDVVIRSRDVFGYSPLDYLCNKHSTTALNVAKSLLRSIFKPRVACIGLDRWREELQTDLEMIEASDTASIVPNVASFRRNLAVHERMEVQSLLEIAVWRMKVKEQSMGLHQAGDGAAIALWNQPSADQCDAFHAHKRTIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDN2</accession>
    <name>A0AAD2CDN2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000094">
        <property type="protein sequence ID" value="CAJ1929816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDN2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="137" mass="15872" checksum="67EC5A49091FB515" modified="2024-05-29" version="1">MQFDLVSAIRESIARSSVSWSPQHVYGHLHKTLLFQELTWWEQKNLEVDGLAVEFCREIEANHQLVAPNPWFFTELAALFVVDSKQSRLDNQLIQEHVALPSLQERWCEKLLEIGSGGHQTACLRPNRLTKLWPNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE05</accession>
    <name>A0AAD2CE05_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">cGMP-dependent protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS2432</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000158">
        <property type="protein sequence ID" value="CAJ1931536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF143">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="188"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="307"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="436"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="579"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1931536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="876" mass="98072" checksum="321EAF1713E34B7E" modified="2024-05-29" version="1">MSKSKNPAFAMWEKRASSNTELPDIARLAVPSASSSTATNVGYKIRKAKALERVEQFSPKMTAKKVVVTSSLADRMKKFSENDNGTIPFSFAGSTNSNKSAKAYQAEEAKKKRAENSKKRHELRKKNQEEEEASASTSAKRTTKRGAPVKQHSITAARVNLDQFVPPTYPKSDADAKLLQEALRQNFVFENLNESDETKLTQAFEKMQVHEGQKIINQGDTGDYFYVIAEGAVRFEVNGKGVGKSEAGKSFGELSLLYTSPRAASVIAQENPTVLFRVDQKTFRYVMETKAKESENEKMGLLKKIGFLKDFKHSDLTRLCDCMVPRNFEKDEVVVTKGEEGDLFYILKEGLMKVTDISVGGTAYEDVTLSPGDYFGERALLLSEPRAANVVGMQSGSCFVIDRFTFEKVLGSFSQVIMRSQDRVKLEGVKTIKDAGLEGEVLDKLVDVIIDREFEAGENIQEKGKETEAALYLIHEGTVNIMSTDIGAGGYFGDEQLLADAQGQSNSEGFITAEETVTCSTDVVCGVLTLKECRLLMDTKTITTDFKKDDYEFRSSAILKRRSTMKETFQSKKISMEELDREKMLGEGAFGEVWLVKADIWGLGDDEYKEEFALKVQNLDNPEHANMRDTIKREMEVISTLEHPFIVDLVSCHETETESMMLMTVVKGGELWNVVHKEQDDGEWLSGISEEDTKFYSLIIADTLAYMHYKNILFRDLKPENILIDRDGYPNIIDFGFAKFCKDKTYTFCGTPNYVAPEIVLSQGHGAGVDHWALGVTIYEMIAGENPFYYEGVDTGTLFQMIAKEEPYPCEKASADAMDLINGLLEKDPTQRLGGLAGKERDILNHKWFEDLDLEMLRHKLVDAPWNPPMPSGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE84</accession>
    <name>A0AAD2CE84_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000136">
        <property type="protein sequence ID" value="CAJ1931297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="232" mass="25425" checksum="4D30AD25B41A238D" modified="2024-05-29" version="1">MMSLQETLNLNNKAVALYHSNDIGGAAKTYYASLCLAKELLQSTAPLQESVNHRAPTPFATTLPQHECFHTSTEVSSSIPMQEKFFVYQSALVLQEAPSFVGVEHRVQSMNIYCAGILFNTAILHHQKSIKTGISAFMHRAEQLYQASLQLIVGLPRSNDTVALIAFAATNNLAQIEFEKGLVMQASERLRFLVHLLRSSENTAARVFAVDEFHGMLSNTLLANGVSSSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEM4</accession>
    <name>A0AAD2CEM4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS2746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000213">
        <property type="protein sequence ID" value="CAJ1932223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050171">
        <property type="entry name" value="MFS_Transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517">
        <property type="entry name" value="RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="316"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1932223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="513" mass="55447" checksum="0E0C1FE8A2223EFA" modified="2024-05-29" version="1">MARDESNRVEFGFRSNGLQLVFHVSIAILIGVTLKATTFNEALLAASRTGTSYTYQTAFLVSFGFTKALSNVVVGRMSDVYGRKIPHCLGWIAGIILGALLYTISQQSNDDNGTDNNWNWYIVANIFLGAQQGWTWTTNIFMFIDVLGPENRALASGISNSVGYLSSAITTYVITAMSIQQSFLLVLVCSIGGFIISTVGMKDTTQFVLLETGSSPSSASHDDEQMNHHPDQVSERSNDDFIEDEEDFVDEDEQEGKPAMSQSRIRKHGSEYEMVALSSSSQNTSLAGSSELDANQIVLSSSFGRVLLQTCWYNPSTAVLLIAGLMTNLITSLAWGLVLIWAKRQSLSKFQIANISSAFTFSKAAMMIVASRTSDKWKTRKPVLVGGFVTAMLGLIITAMADSSLAQVIPVYMLLLIGGIVIGCGIGSVYCVMAGSISDHTPAMDRATAIGIYKLWRDSGYAVGGLLTGLLADIFHGSFVITTAVVTGMVGVLVICISKYYREGQIAVQHDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEZ3</accession>
    <name>A0AAD2CEZ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEZ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23314" checksum="9570FD798FDA8D8D" modified="2024-05-29" version="1">MNKPLPEKVKRIMVTAISSNNKRKRDLLKNDDDGGMMILREHSVVVNNKNHYCPDTSETGKFPLIISYNGGDTDSTAASDLSDSEDEANKKRGKNKNNERVVLRFSIMTSTTTGGNKVDAKAKPKTTLQNVFKAYAQHAKYNLQDLRFFINGSHHDTDSQLPVSNLKRNHNNNGTNDLGKTSSIGSSILVQVVRQGTSRKAAKKTKKCHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHE8</accession>
    <name>A0AAD2CHE8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1923013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="280" mass="32084" checksum="3ABE63F7B7996374" modified="2024-05-29" version="1">MTEEHDSNYCVGVYHNTNTNSPPVSVWSPDASLEDSDEQEEHMKKMDDELYIRRVFSFDEWEYNHPQYKTKSPLHREPISSKYDMNRYNDSLKSLIQHQHLPAEQQEQSPRTSPPSLFQEIWNKKLEEKKDCCGGAQELGYRNASFVTTASTSLETHSIPSPESAFRQFQNKHAVSPIDTTTAATTTMNEEAPWTPCIPRESSLSCDEGSFVHIDLDDQEDNSSGMMMIIPPSQRPQQSSRPHYASAWFGIPEFVLVPRNNNSSSSIIIMMEEEEEEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHN8</accession>
    <name>A0AAD2CHN8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000236">
        <property type="protein sequence ID" value="CAJ1933029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHN8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="181" mass="21540" checksum="6D37C148E65CCE8F" modified="2024-05-29" version="1">MITTADIDKILEDSYNYMQIRSTPPSHHLLPMSFDDDPNNMEPLPMRSRPAQRQHDFVLSSFMLELLLVPKQPENTNLRREDQSEDTVEEEEEKKAGIRLFQEKQWQAHFQKLEQFKLRHGHCCVPHSYSRDSTLARWVKRQRYQYNKKVNNKLDDTTTFSTRRIQELEAIGFVWHPPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI42</accession>
    <name>A0AAD2CI42_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000380">
        <property type="protein sequence ID" value="CAJ1934761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="735"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="916" mass="100890" checksum="C344E4C9D103FDEF" modified="2024-05-29" version="1">MSSPSSDSSASDSTEGAGQSWWAAPYKPGRPDPFTAKSPLGDDDDNDEVVRIPTSSSSSSSSPSSSSSAQSTSKPLISEPAVSIIKGSMGASNSSTNNNGQRRKMVEIAPSPSDPFHYGSIATSSSTRSTRDGQNIPPPSRMPTINNGNSVYEHQQQAPRARNRPPPPPPPPLDEGMNERSDFGQQQAPRTRNGSPPLDDSDFGQQQAPRTRNGPPPLDDSDYGQQQAPITRNRPPPQDDSDYGQQQAPRTRNGPPPLDDSDYDPQQATRGRIGPPPFDDDIYGRSDYGQQAQRTRNRPPSLDGADYGQKQEAPRIRFRPPPLNDDIYRSSDYDQQTPRTQIQQPPLNDAIYERRRKNNRGSTMDAVPVSFRDVTYASADAARQRPRNTDNLKSAAVPLKGSDEETFMPNDDNGMRSTGTTRKKPGRVRRKPISPIDADVIPSPPSYGSDVQSSIPASNNAFFQRPPKPRRERDKSRKTASPSSQTEPFYYTSDVYSEEDPSIQSVFPQRTSLPSRSGGSMSLFENSPESLFEDSSQTRSNLETYMQSSSSSPFSFQYDKEAAAMNGMDFVKFLESRGMRDNGNSQQQQIQRQQQQNEWQQQVITNRAYQTSIITRAKNRTPPTKLDIAASTLGGSLLGASIGIAGALNPELGLNIVGQSAMLPPVLWAAMIGTVGYAGGVADNDAGYSIRHVFSLGSSLKTGIKSFVNSARMTVEKTANEALRMVSGQEDPPARIHHVTIKTRDLASAMDFYSLFGFESKSKFRIGQTRATWLDNVVAGAGRIELIEVPSDSNRRALDRVRNQELLGWNHMTLDVSDLMWKNGFETLSEFLAYLNEKSFYQSGKGLSLAVEPQKQAIDDHIYDTAFLYDPDGSMIQLQHLTKERAEDYRISAFHYGEPTGGQGLVDQSGSYQGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJQ8</accession>
    <name>A0AAD2CJQ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1754" mass="196622" checksum="3F95CE8F21DAF848" modified="2024-05-29" version="1">MTPSRRTMRNSSIELLESYRAAMMETQDSFQDTEHDPVDSYGEEITRILNKSRAFQSYPTEDRSENLSAKKLADPASTSDSSNDCPRESLQSFLQRKWDFLFWNTKPIESLFVLSSALFVAALWTSAVVSATASWLYFRFLWMLTTMALSVWVDSAELQQLLPLSLQKLVGACYSVLKWVDDFVLCGIRYQGREWNKKEFEVDDGKSAQSSYSYLWALPPPSVRQCDSSFNWEGNERGDWSSETNQHAKAIDFCYNMLRQSAIRQKFSKMRKTAGRRVSKLGPVVSSNEKNGEIIAYTSELNTPRNVAARETTRPPGLTTIHIDTSNREKSKTPKIEDSMGALQLKSPTDAVEVMHHKEQIFFDSNRTIRHVKSDDSIAHKLTEKLILHDDDISLSHDIDHKTGRVKQDAEARSEENAADMNWMDVGAEIGLKLLGSAAVQKAMTSHDTAERIHNMKENFGRTAPEVDSRRSMTTSTSAQPKAVLAPPVHSMWTSATAAAAASAVISPLHSDNGDPSSAEEELRHQEMPLHLQVNGEKRDTSDLDEDDTNRVIRGNSSLTSCSGGIGFSSSASFPKKRPTPRSMQGQSLELASKTSVAPKNHEKLPTIGPGVKIVVPLSPYQPGMKSSHTRHQSSFQMATVVSSKRMFVGNTSRDDGFDTNCLSVTVKLDRSFLRGGEFADLTFRIMDAWGSRYVPKHSKLPIGTCVATRYGIGVLVGWRVEDDCHIVRSLWQRRGLGSVAAYLNRDSIFSMVEAAVGFHVKTIQGNGTVVAVKCDGRGYRYGKFSVKITDDGSKLCGQNIEIDRSEILACPSAQFIPVIEHIREAAMYRLQLFDYKESLEARISGVSSDPLAFEGVVWQNISKWSEMLWKSFLLAIEEDEDFDDGMNEFIATVIKLLDKLDVSNNNVNKDTECSDNHIITAINSTDAAEVEAGENTWVHNIFGIYGDTGETGVVATESIEVEWLPSSDADDEAIRQKSYSRIFNVIKTMMRTIEYTKAACVDEPDLKLALSICHEMLLFARTVIRVQQKNTNPFSIKVWRRALEEIAATFGPAKERIERVWGGIVDRIEQQGNRAKVRILEFVDIILQDDVLLLAMEQGDWGRCLDHVEDAMVSSQIVDEANREHYHKAVHFILNHFANASSGGGVAGARNNEKLTQFAHFIQCLASPKRSILRFFLEETTLNTIERILVRVFDGDPSAARMLTINAQNFHSLRQFRMLKDFTVAGNKFWIPLLDAADAEFAWMVSQMPDGTKDYMVPFSKLLSLCIVEFHKINEGDITNHFLEFLMEEEAAAIIHDLDMKLILALESFSRDVRDTMVILPYYPSIEDDILNLVDEIDIDGFLREAALSLDDPEKLSDFIREKTTIAIERFLDYLPKMSIPVEKRDLADGWVLTCRGEDGGDLTLTDLVVKRENLVCQVLGGDSMFFPMLSSDGGAAGKLKKSTSASSPKQNGKAIAESSILDEIREMILQAKRYNCWNVGVGGIVAPPSDRYVASVLDDLPVSKVLDSGIELWRNLEIDDDELLEIAIKDIAYQIRLNAGKKPERNSSNGESTDEAAIANFLPSITSSFSSAPDLLKKTSSSESLGRRFNPRDDPTVLYLEIKMLTFHLEKFFFRIEKEENRRTIFDPVFEGCGNLLVRNVSIKLRVECLKTQSQGPNSAIPILLLRELDVQLEKVKLEVRETGADWLLNKVVQGFEDSITEVVATNLEDQVREQVDLILDNLNSYFEVNPAIVLGLLGISMDDLAEHVEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKR4</accession>
    <name>A0AAD2CKR4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKR4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="181"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="264"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="346" mass="39737" checksum="E8DE0141D3730FDA" modified="2024-05-29" version="1">MYGAENNNLRSDSYSYSNIEDEELLSLLRSPFLPLDAPKVSPSPSHPHRMPFSFHDIFDDASMEPSPLKSQAPVTANWPQMQPRYDASLLIDESIVSEEDNMSNDTNKKIGPTIDPTSVGSKRSLGDCSSNNDEGSFSVVTSSKRSRKGFFLSSNHNHQEGDPCNKRQRTTTSTAKSRPCQDEQWRAQFQKLIQYKMKHGDCSVPHSYQEDPALARWVKRQRYQYKKIHDNHPTSTMTTRRIEETTRRFQELESIGFIWESHVMWQEKLYELKAFKEKMGHCNVPSHNPENVGLSAWANCQRRQYKLHKSRSSASSDMAIHRFQVLESMGFVLAPQQVCTQLMKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM19</accession>
    <name>A0AAD2CM19_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000746">
        <property type="protein sequence ID" value="CAJ1938648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="124" mass="14022" checksum="E2482748D283E672" modified="2024-05-29" version="1">MNANDEIAFSGMQLSRQGFSGAQVRQGFDATQAQTPQAVKTGYFDMSNLFHNAIKGKDENGNDDYFIPCPAGTTNVKLQAKWHYASEDEDLLILLMKQIEACSVGIWRNMNFYVMRKTIQVQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMK9</accession>
    <name>A0AAD2CMK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000402">
        <property type="protein sequence ID" value="CAJ1934859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMK9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1934859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="251" mass="27618" checksum="02A0CA77013B8DC7" modified="2024-05-29" version="1">MRSNDPYVSFTAAVKQGTLWRINELLDNGRVDVNLSHPAMGNGKTALHVASENHQSGVALLLLDRGADITAMDDSGNTALHLCTPAIARLLLRRGAFIEEKNDDGLTPLLLACKQWNVHMYNFFLDEGADVNMKDNEGNAPLHYACSGNRTDGAQIFLNRGADMNATNRTNLTPLHHACQHGCSTVVSLLLDRGVDVEAKTINKMTALDLACHNNHFQVVWLLISRFPWLVLGRPSPAAAETQKKKKQRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNG6</accession>
    <name>A0AAD2CNG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="430" mass="47671" checksum="ABF6F4B1A3173492" modified="2024-05-29" version="1">MRHRRPPRVDLSADMTELDSTSIQESFLLVEEETKRKIEMVSRSEYRRGHKITNNNNNNNNNNNNNNNNNNNNNNSGYESSDEIFMLHCSSPLSHASTITMDLLSPSSSMMTDSSIMIEDDASLPLLPDLQAVHTDEAMIGTVGGIDIGTSFLPDTSPITSSDKGPTVFMDDGSFTYVTLEDSKSSNSSGDVFNGISNATNPTPATLNFALHTPHRAAMRTPHSYSQTPYTYETIEGSDAMNRTGFASQFTFETIHTSGKENTPNRTNTTRKNKRERIDLSAQESPLESRRMIYSPLPRSGPASTPKDKKKQMQTVDLDYFSIDEYTSSPDKSVNCFSIDSYSSKSADVDGLGFGGTGMTTLDMARTKRDQSLFRLRSMGGGKLHSMRPLPVPSQHNNSTGGISQRKDHVAKQRRRLSEVFQSYCLSMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPB0</accession>
    <name>A0AAD2CPB0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS18013</name>
        <name evidence="9" type="ORF">CYCCA115_LOCUS7642</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001068">
        <property type="protein sequence ID" value="CAJ1941734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002006">
        <property type="protein sequence ID" value="CAJ1959592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1941734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1959592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="215" mass="24593" checksum="A3C7D13A7F04B01F" modified="2024-05-29" version="1">MSTENAPEFKLILVGDGGVGKTTFVKRHLTGEFEKKYVATLGVEVHPLMFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLTRVCENIPIVLTGNKVEIKDRKVKAKQITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLSGDNVLHFVEAPALQPPEFTIDEQTKSRYEAEIAQAAAQPLPEDDDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPC4</accession>
    <name>A0AAD2CPC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732:SF8">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042139931" description="Lon N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40240" checksum="3D7227EB490DEE73" modified="2024-05-29" version="1">MKMKGLLCIWSVWLAAPESIAFVANQQQHRGTIRINDFSLFGISEWRDSIFNLPGADRQPLGTEVGPPAKEICILPFPYDEVLLQGQEKQLRLYEDRFIKLFDYAMEQHSGVVAMGLIAESGIIQTVPICEIEAYNRMEGFGIFVTLRVCSRGQLLEITQQDPWLKATCTEISDKVPPNLELPNLVASNIENFMLLLSSMEHRLAKVSDKDGDGDDKDVAEMRRKLQAAKLDDRFYDDLGDDEDDEVSELDRKGRFTQAYNVALSTDTQGYCVPTGTKLDRTPQELTAISWAAFCTNVLPDEDASFRIQALDADDLFDRLKLASHMLREKKSFTRQMMEKAGLKLKGDEDFDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPK2</accession>
    <name>A0AAD2CPK2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPK2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="192" mass="20856" checksum="4DDED09E7383056E" modified="2024-05-29" version="1">MKSSTVPLHYPKAKCEVKQRTDAWGGVKIIVKGGSVYGYPHYRSLRAIPQELQGIDPDVWASFFVQVDSIQESSNGSECIGILVLFLGTGVFFTLLKLFGNAGIAIVGAVATMVGMVFVVPRTPKGQRQSLDDLCLLYEQKFRDQGWKVSCHCESTPPPPRPTGGIHGQGSHSIWVVHFIPTGENGSVLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ28</accession>
    <name>A0AAD2CQ28_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000236">
        <property type="protein sequence ID" value="CAJ1933043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ28"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="238" mass="26317" checksum="3C471F63BD2C8953" modified="2024-05-29" version="1">MASLPAQYTVTQRVCALNNFGVTSLNIGEVSSAYGYFAEALETVEELILLLQQQADINEDLECSKVGYCFSYSPSESRSLEGYAKKQDAVYICDRPLTVSLVGPCSSEHSQQISFLCSLLLFNMALLHHSLGLYDESSTSLEKAEIFYETCVLVGKTDNKGTVHDDQSVLIVGSAINNMAQLALEHGNIKVVRHYLKQLGIICRRQSFANGSVLYQNEWRNIFSNVLLRDGLNVARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQQ7</accession>
    <name>A0AAD2CQQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="234"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="308"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="404" mass="45885" checksum="9A195CC2C5D2389F" modified="2024-05-29" version="1">MSQQNNTPVSCGSSLMTIAQDKHHSSETAADDCLLHLLSMPLIVGPDHHVVLVSSPPMLEPPEAPPLFSTCDDDLFHYTNNTTIPEISVESSSNDSIMEASSSFHVLVRPSSEEQQPPHDDFEPTPIHPRLSNVHNSAKPMILPFPSLTGAVPLTDFALDRFIAQELKNEAAHTKQQQDAPVIVISGSKRAMTPTEESPPITLRPAKRSRIRQVSNNDTSDDEEARVPRFRSHQEKQWKDLFDQLLEFKKEKGHCLVPHTFDENPPLARWVKRQRYQYKLKQEKMVSTLTDDRISQLESVGFVWDSHAVAWGEHRLDLVQFKADFGHCNVPSAYEKNPSLSTWVKRQRRQNKLFWSGSKSTMTMERFNALNKLGFSWEIKTRKNKIQGARQQHVCTTVLLLPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRB0</accession>
    <name>A0AAD2CRB0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001146">
        <property type="protein sequence ID" value="CAJ1943833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="58" mass="6293" checksum="04C40318C98DFF4E" modified="2024-05-29" version="1" fragment="single">MGDQEIFAEDGGLREKVPKGKVVICDRVYTDKKTAGNNAKLALPSLADPGPLFKFKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRD2</accession>
    <name>A0AAD2CRD2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRD2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="485"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="647"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="900" mass="100835" checksum="B27A0C0868868147" modified="2024-05-29" version="1">MSASSSYFTSNRGQQQQPRSRRNLQQTAAPSMGSRAPRNLVAARISSNHPRGSYSQQTSNFANHVSRHRRHNLPRTVTPTNNAAPPSWEDFDEDPYGGSNSFPRSSRSRTQSSDRSVVSTSYVEMEEEIPMDELIEDSLSVQSMPPIRRTHVNHRRARSGSNNDWADANSYARSSSSIDHNSAGHNNNHRRNQSMDWGSTELGQIGLHRRTHSNLSQDWADDVSSLGGVEDRPNGIGDIIRALKHRSKSRPSHLTAEERVLWESIQISLNSARNEQMENKRALERLLQDAARREAQIERKLITTQRQLVATNGKSKSNSKSTHMEVQVRDLETTLKSKQADHEREVRAMQRVLAAMTEEREQETGNLKKEIERLTEKYEGKDGCTDSTASETSSFLEAQLAGAKVENQKLVEEINPLRTELETARDEIANLKYRGLDHSSSSLDRRGIPRSQSMTPPRYGVSSSNSFDAESASSAESVETLQRSLAETTYSLENAKKIIASLENANNALAVDLRAKLKAKEQELHIAQTESADFKHRLDILATELRALQVRQGDSDRSQRGFKGQIQDYQDLVDLLEKSVSGLQSASVVHEVSAATGQPDLSNVDQIGEILNETLAALRSTLDKASSSKEESKNSSEITIDGEKVSMKQMKDLLKKQHEQMKRLRKQVDEKNEGLESIKMMRTEIQSLKEKCSSNEKLLTKKDRELAVLRSSLPEDDNNSRGGYISDDESGDEDEAASGTILPPPSMNYPTQQSLSNILQQIGRPGNSSNNEVETLKEELLKALGEKELASKALKEEKESLANAKMIISSLENANKRMTADLRLRLHECNSEIVALTDKSKENEHTASELREEVERLKKEKAEHEAEINRRQGVDHPQDESADPKPEVEEKKEETVAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSQ8</accession>
    <name>A0AAD2CSQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS8527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSQ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050994">
        <property type="entry name" value="At_inactive_RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF8">
        <property type="entry name" value="OS08G0117700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1943609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1102" mass="121116" checksum="F2FB803782A88F2C" modified="2024-05-29" version="1">MAADAWSITMKKHEDESDTYDPSSMSLLIERVDRIESQASKSEHVIEDLQRRLVKAEQRLSPHHDNNGIPWRRILACTKSAADKCEHGEFRDRDIKPDEEYDLPMDIYSVVSAWPPKSRPFFTALMVIAVQITLLLLLLTDQIGSTGANELVVVPANVPSIVHAAQALATIIAIMDQDDLRSAIEAFFDGLPTRFKGDIAFHGMSKMQWNFSCAVRFLQGFLSVFASFVLAVQSETVFDVLLNFLGVKFVSELDDLAFNLSLIGYFGRKCERAAKRISEAQFQQDNRNKVDETTWSCAWFFKYAHVFGVFGILAMLLALFFYVLISQNSGAFSPQVIRMQAADGEVPFASLFRGCYRVSQAGTRHERRLEYEQMGFEKSGGKFGFCGDLEGEQAWTFMIGELATDPCRDYNGRSEPTTTYSILDGAGGSQWFAREGQPFGNIEVSSVLGAAVNACGRTPFDQSGVIICEQLEFDGHIDAARQQESRSKFFNKVFLNNSDSSVYTYPALTHPIFVGNSSIPGKYDLVLFTGQSWVLTDLIESNITREQSELSMQEYLDSDPAFSEILKNMIYTGAHVNIVTNSVNNEDNQYTPLGMRWFRMQEQDPTLPYNYPTGDQSRPVEIHLSCATCNNITNPCSFGGICLEGGVCDCINGGSGALCTHVPIGDAVCHPYFNSEQFGWDGGDCCAGSCIGPQCGLGGLSRPFDIDGDQSRDLFSILGYEFCEDPSMAPLTIELHNFKVLQNDEYNAVAGNEEGATFCSTSTINVRCDGVSYLHFPAHTFNNESDCTLSFTETIQVPFGSKCELSSSIACFGLICLDHNVTVFYGSDTESAPIQSGSVKNQTKMSFGVPSKCLTKSLLRHSSTIFDISTHQGQAARDLSNDGISEFICIEHNNLLFERYALAVLNASLHFKSSNWDAYQCHGWGIPAVRTACSNWSITSLTLAADAGEISGTIPTEINLLTNLEFLTLRLNRLIGTIPKLTLPRLEGLEIWGNQLTGSIPTELANLSSLLALGLASNKLTGTIPTELARLKNLSGIWFDDNLLTGPMPSELGALPLASLNLMNNSLTGEIPLDILALTNLTVCTLQNNNFSGGIAPAVCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTH8</accession>
    <name>A0AAD2CTH8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTH8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="131" mass="14601" checksum="D71955D37125DC05" modified="2024-05-29" version="1">MNSNMQERREERGVSVNGTPTREDRQFTRLSKGYAHASQVVPSYGEVCLGHGDPLMKAAVEHERVEATRNANMSPKNSHKKKLSQRTFDVYADKEVHLEEHGSPVAGLGINDVVHIDKDTALEIPCLPHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUK0</accession>
    <name>A0AAD2CUK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Folate/biopterin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS8539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUK0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17484">
        <property type="entry name" value="MFS_FBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF0">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041948955" description="Folate/biopterin transporter" evidence="9">
        <location>
            <begin position="26"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1943633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="63557" checksum="B52916BDC56A56F4" modified="2024-05-29" version="1">MKSCKYSPLAVSLMVVFTAAPLIHGFQSFPTPPSLSFQQFRSRSLHGSTTPPQRSVVGGIKRRRQRTAMPPPLFVIEREAELSPSDDKVVNDDDDDDEILSSPTTTTTEKDGDETATFDLSNFVKDTIFLGIDPSPDVIAIASIYFVEGALGLARLAQTFLLKDELHLGPAELSALTGLFTLPWTIKPLYGFLSDGIPLFGFRRRSYLILCGLLGAFSYTLVGNSFFGLLPSTADGTSNSLLIPSTVAALIVSSACIAFSDVVADGIVVQKSRDSQDPKLAGSLQSICWGSAAIGGLLSAYFSGSLLEVMKPQDVFQITAILPFAVASIAFLIDEKPVGSMDTDTGLIVEGSPNIQTQLDSLWQAIKQPSIYKPALFLFLWQSTPTSDGAFLFFMTDELGFGPEFLGRVRVVCAVASLFGVWLYNSYLKTKPIKDILLWSSILSTPLGLSSLLLITHANRSLGIPDGAFVFGDDVALSILGEIAFLPTLVLAARLCPPGVEAVLFATLMSVNNGASTLGTEIGALLTKQLGVTETNFDNLGLLTVICNLSSLYPLLFIGWLDEVGGKSEEELEQEQEQQALAMENGELSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVT4</accession>
    <name>A0AAD2CVT4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="959"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1954"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="905"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1975"/>
            <end position="1987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1987" mass="217357" checksum="EC9DAE0F1DD36537" modified="2024-05-29" version="1">MASSIPVDAVERAAVSSETTDENDSLIPDTSATSSALPSAEVAAATQVSSYQRALLQFLSEHNCWIPDPLDDESSRRAFLRFLAEHDPSFHHASDNSLVLSALPSLDPVVAVEQSSSPNTVSDNESSQELNPENLQGQTNDGDDDDSNDMFPIFRVNLDPNPTPDSTPLVATSGLLQPSMTSRGRSADDERGPNATSNEDLIMMVNTFFDHMVSNSQNQSSESAGHVSADLYDEDGVSVSVDSYDYEDEDDEPFDFAASSSDEESSVEESSEEESSNDDNDEDDSVHTSEFLWERNTSKPYFGSRLFQHDLLEAKFPFLRNDQGAIVALGDEWDSFLYCGRRLGRTAIPHSDGRCGPNNGPQCPSCQRLQTNEKYQILEIIFPSLDRNILTAALRKRGGNAFAACQFLESSFDGLHQVPSEIAFPGSRPDGIPEPCYPVSDSDAHNVVGFFDGSISLATAKMALRKNEHNLEQAVTYILDKSPLELVIETSQDTGRVSEYEDAVLQFQVKRREIIQEVALKLSSPDAIPQELNVLAETMVPEMDSGKIIPCAIEDGHGMVQPAASESIKCIVCALSVGTKYAGSSYCPQCNHCEGCIQTKVVYKCPRMGNGGHLHFCPLQPVKIGPDRKGYICDIDSKGCLHSENHNMSYYCQECNFDVCAVCISQPAPVYYHRRLGRMIQLDEDDEELFSEEEDEEDGEEEDEEIPEVEVDEDEPRVQSNSHIPETPFEREVRRRRDTTAAADTRRRPGTTNEESMQLNDQADFSVVPTSDPNTIVRAENEQDTSQEATTAQTDEQPGAISLLPTKDSTATAPVEHQADTSHDATPAEIAEQSEAPSVDPTIGSTPATPAENQQVAAEEATPAEIDEQSEASSVAPDLTPTFPAENQQVVSQEATPAEPVEQSEAASVVQTTDSSPTEEPKESKPMFDLHERIAASRWGATEEEEDNAVEVIIGSGDVRSKERRLKRKQSSTLEDAPPMRHNRPETLLTSKFATALQNYICKECPAASNVHHVESLLHIAQGNDKCCPSEAVCQAVGAGKMGIAGTCLLAPIYGAKQKKTGEMRCFCGDLIDSKTAPDGAVGCLNGHALHPSCAADYLLSGGNCPTCREPLFFPKVGKAEAAAAEEYLEAELQRRRKEEEEAIRKEQLANGQVFNVNDIVRVSSDVKLCMKELMASPGKTGWTPEMDSFCGSIGRITEVEEGKVKIQNQELQHTFYLPRTVVLCRNCSGKVGAKDGDPPVDEGNKGLCLFCNQCNECCSKDDLICTKSSVKLNWTPSTVSLIGRATSAALWDKSLVDKDLATAAAAEQHIIRLRAEMNAVTTARAAVQDALGNIKGAPSIKALDGLKEVVSPFDFQRARHLLGLMDHWGDSPSMMKDKKAIMETLRKGDIDTAARQIRHHNAALVEDAAKWRYASSDHHEYVVESWAKINLVAWPSLSAPRTGYCLGPSVRFRSKEEELDSDGNIWLLVDENSLILPQFVNGKQVLANPKDIYAYKNLVGCQVIPGPKWNNDRIEGVGTITAVSGSSIRVKFPRSDSHSWYYPTEDNGANLLFANPPAPQGWLCMTPRQVPVVRRGRDALQCFACGDGLLPEETTAHESIQLVQKDDEIKVGQTLLVAATLEPVQVKSVENEHVQCSFANQDSKRSISVKFRRDDLLHPCSATENTEEKVSIGGRERCRQDVFMKHGSIADAKAAWNAAKSSNGNPSGTELLTSSYASCVKGHLLHARCLQEALIAGKKCPFLGCNEPLWAPKVKRLQPDSDACCGGNSATTDVAADDNNNNTVSGTEAVARARNENEEVDYHMDRELKMCPACFSGPLLNQNCNDMEAHHGQCVHHAFGNDDENPCYFSADGSDIASSLMQLSGDKKVVDVLPRCPTHHCVIMFSGCMVCGHLFNETSWSDLPKWDPCAKTLLDVDRKKRKAAASLVSEITREAALLEYERDAVDSLWSTKGNDEIQLPPLPPPAMGFSDAISDSESDSDEDSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWJ5</accession>
    <name>A0AAD2CWJ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="380" mass="42424" checksum="B6149B254250A7C3" modified="2024-05-29" version="1">MSVDAMIMAPSLQLHIPMELQIYSEADPDTKITDLPTFEESSIRKICKLGSGCHHDVYLVSTQSRQQLALKCLSQSTVPNQDLSADLTNDLIMEAQILAGLDHENIIKVRGVSCNPIESGTAGSRYFFLMDVLSDSLFDRVQRWSKDESCFNGIKSFILGKRTRKLDPKKMMSRMETVAIGVAQGMAYLHNKGVVLQDLKPANIGFDMETGQARIFDFGMARHSLDLSMNKTAEICGTPRYMAPEIMKGETPTKASDVYSFGCVLYTLCSLKVPFRSFAAKENELEEFKAMVIAGERPSLKCIPCPLVRSLIQDCWAQDPLDRPTFNEIVEERLPDIRTECNNTKQKKLIKRIDSGSLNDSIHVSFRSDSGITISVKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D0N0</accession>
    <name>A0AAD2D0N0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma-70 region 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS9820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D0N0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050239">
        <property type="entry name" value="Sigma-70_RNA_pol_init_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30603">
        <property type="entry name" value="RNA POLYMERASE SIGMA FACTOR RPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30603:SF47">
        <property type="entry name" value="RNA POLYMERASE SIGMA FACTOR SIGD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="Sigma2 domain of RNA polymerase sigma factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="Sigma3 and sigma4 domains of RNA polymerase sigma factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042058021" description="RNA polymerase sigma-70 region 4 domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase sigma-70 region 4" evidence="7">
        <location>
            <begin position="270"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1945675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="342" mass="39243" checksum="E656F5114C8073A3" modified="2024-05-29" version="1">MKRSHCCFLWMSFLSSQGLAFVPQTLPTEFVTALLKSTVDQEAVETPLLEDRKGHINPELAQRIYKWEREQRLNKNLPHLEHSTRDGLRWVLNLVNKLDRLNPNASNSKDKHEDLVQEGVIALMQAMTNYEDQARPQQSFESFAKHSIQNALEDFTWGVKTASTGGPQTSKPALSVESTVEIADPLETHYSSQEEWEIREPEQDFVDSSVRYEGEDQMWVHQQQVAAPLREIIPDGDEEEALFDGGESSLDDLALADLIRFDVDEFLATTLEEIESQVIQMRFGLDSVDGIPKTQKEIAYELSLTPSKVRKLQKQALDKLREVYSNRYISQDDDDHYWQDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D1C4</accession>
    <name>A0AAD2D1C4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS10493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D1C4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="422"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1946351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="477" mass="50507" checksum="EC59AF62A2CCF18D" modified="2024-05-29" version="1">MASSSTFPDPAIGLPPRVESDSMGSLDIPADCLWGCQTQRSLMNFPIGGTESKMPLEVIYGMALVKKCCAEYHAEIGKMDAKVAGAIAQAADEVIAGHHDRQFPLVTFQTGSGTQTNMNVNEVLSNRAIQILGGEVGSKAPVHPNDHVNKGQSSNDSFPTAMHLSLTKMVVETTIPGMEALLAALNEKMEKFSDIVKIGRTHCQDATPLTLGQEFSGYAMQVEYGIQRLKNSLPSICRLALGGTAVGTGLNTSIGYDAAIAERLAKATGLPFITAPNKFEALAGHDSLVEVSGVLNTIACSLNKIANDLRMLASGPRCGLGELSLPANEPGSSIMPGKVNPTQCEAMTMVCAQVMGNHVAVTVGGAQGHFELNVFKPLMIANLLQSARLVGDSSQSFSSRCVEGLTVNKSRVDELMNASLMLVTALNPHIGYDKASEIAKKCHKEGTTLKEGAVASGYLTAEQFDEWIVPSEMIGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC89</accession>
    <name>A0AAD2FC89_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1907301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC89"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057413">
        <property type="entry name" value="Beta-barrel_INTS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051113">
        <property type="entry name" value="Integrator_subunit6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957">
        <property type="entry name" value="DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25462">
        <property type="entry name" value="Beta-barrel_INTS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1907301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1169" mass="126944" checksum="C5F2ED9AB6F7177B" modified="2024-05-29" version="1">MRNIGLGFSPNDKFLLLSTGRQHSQQSATAACGAGGRLLVGYGDHEDKTSDNPGDQASRQSNVNSFQKELKQLQATDWDPSKAAKGRSQENRPTPFPEDGGGAVGLNAALSAGLQLLSRYRLANRSTENFGMGRLPSSALLNPSGGGAAMHALQPACLVLITDGVCLRSSSTDGGGSLQLQYGNMPLREFYKEPFRWDQRIFCLGVGAKDGVQSSQFLHPHLRTLCEVTGGSHLILRSSVSLSQVTGHLLNQIAPPRPRDLPIPDPIQNLDRSNRSLVGGNGTFVSGGPVCCFQALEPEMDGQAPPRYRAMLLYVPHKPAYTQNNPAPKEQVEFQSPIWCIPESFFPSKKLDTLPPRPAQPILLFSRYPGRLGSKCFEAASLMKALARLDQLILSSRKMQGQQQPKLLSRDVYICDWISPDQKATWGPQNPDGMEYFPVLVIGAGRPALNDGEANYFSIGILHTPPRTSSLGSSLGSATRVSTLTLLPPEPHILLPLLLRAAELEHRALKKIQASAEKDGAYPSANITQKLIAASRNVHLDDHWRNEFRAYLFRLPPYYQNALKRSLRGILPTSVAALVAADGAEGSLAFQCFSKNCAQKIRFAEQQAHERIERQENQEARLRSRGNFVALPIPQQQQQQLQQHGGKRGADAAQPTSTAVGYGQFDARFSTDSFLAALKNMPAPWRMGVGTKKTKGTAAPLSKSSPAKVGKRKRTSAVVSLGDLPANCLMAYYESRRRWIFGGSGLSTRGLFIDGVPNDGCNSQQCGAEKDIFEVPLLSMAGVGVSQLNSTTVSKMGDYRERLLWSRAPVVGYGSNDSAGVSATTAVNGAPVWSVDDDAMPVAFFDSKTGEFADSVQARVNSRLYVNFGNPYKDKRADSLVPLKFLSQSPSMQKARNDEDQSGAMTPPGSPPHDSFSSIEGEGEAAFAGKPISRKSLVRKSPTRSDDGIDEAPVKRRKVEAPPSPVKANHEDTSGTHSKTAHPLPQPNRVKSEHAKQPPPARRPSLPESAPRRPSLPTLPPRKSSVPAPPSQPGKPTAKKPLPPPPRPPPPKPPPSKKHPGPNSRPPPPKSSPSPSPSTTKPPPPIRPNSVPPKFPSIQQQGRPNPGQPPQGQKEASPPPKPAIDYQSPEQKPNVNLPPGWMCVWSKSQKRWYFFDTKTNKSVWQWPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCN0</accession>
    <name>A0AAD2FCN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS2469</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000167">
        <property type="protein sequence ID" value="CAJ1931618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="340"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="361"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1931618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="420" mass="48341" checksum="95C54BD11E56C1FA" modified="2024-05-29" version="1">MLEVVSSKGVEHLDEEDEVSEKHKSSKKDRVVDAREGFKGNLFLVLEYVSHDLTGLMDVAYRFSEVQVKSIFRQLLEALHYMHDHKYVHRDIKSSNILIDHNFRVKLADFGLARCLEPAILDKIHDRGNSQEFTNKVITLWYRPPELLLGETKYGTSVDIWSAGCILAELILGKPLFTGKTEMDQLKLIFEMIGTPTSESWSGFEDLKLFRTGEVSIESSKTPKLRHKYQNKMPAPALNLIEKLLELDPKKRLTANRALHSRYFLAEPKAPVRPEDLGTLEGHFHERQTKKMRKEAKALGERSRQTALEGGCSEKEAQEAFDETYRRIVAKVACEGLKISSDPASSSSANASTKNGMPNKKRLDKDKRRESHKEKHLDRHGRKEDARKREGRERNEKRKRRREDEEKSRKLIAPNADDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCR8</accession>
    <name>A0AAD2FCR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042087159" evidence="2">
        <location>
            <begin position="20"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1924195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="180" mass="18367" checksum="3CCB84B7A326A1F7" modified="2024-05-29" version="1">MQVLLSLFAGIMALNAVNAQPLTQNCGSAQCKFEESVSCRQLMTENTFTGTCCALDPTPSGGCTVSVSAGICYYEPRAPCEGCAPGANGKFLGSGNADGCPVTQFDALLWDEATTQPTEPKADLAETFEPTATPVAGPTPPPTEASDPIAANEEPAANISSASRMGMTAVVVASSVALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDH1</accession>
    <name>A0AAD2FDH1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="610" mass="68809" checksum="FC27604E4D4F9E0B" modified="2024-05-29" version="1">MAPPSSPLVLSRPPRAPNAVSLSIHVDHVEKSGIPRGPSSCRSTHFLDGFNVDDCLDVRTIPDPPTPQPRKRRLSIPVNLRSLEDVTNNPSANKSSKRDDGEKKRKARKSLCHVPSPIVVQQNPVIPPLVPHRLEEGQPESSEADAQEMVNHHHHQPPTSAKTSICFDDDENEDNDGTVHRRISSSRNGSRRRKKRQSMIIPSELIIPPQPLDTAQAVLPKVSPPSSATMKKKFEGSLQDMKNLQALVRGYCDLPVEDRDISDQARTILESTGYPLHNNVNRPASPISDNDKPIRNLRRSILRKIAPVIQDMDKRKIHDTKMLEDATGCRVEKGTRSGKYRYYSLETSNKVPPAEYKDRYMAFIENGAGNRAAQAEAWKEKLIENQDEEEVVMEEQEEAMISTEVVDPDASRQLKTETKLREEIAMEEPVSPLSDTSESKVLQVESPQLDLQAQEESSRAEAPVEEHDKESDHQQQQEEGDEDDKMELCNMSASLDMGDIDALPVDLDGGSETEAQEKKEAKANEARVDPQNQEEETHASQENQLQVEERNSPPVVALPSRERGQSNDPEIARAEKRLWKRIDDALHDYSEEVMKILQKRKRQKTMKHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDS7</accession>
    <name>A0AAD2FDS7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS2293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000136">
        <property type="protein sequence ID" value="CAJ1931229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDS7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042248471" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="620"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="658"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1931229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="705" mass="77670" checksum="8AC3346AB191D1E2" modified="2024-05-29" version="1">MMMMKIIAAAFVANLFVPGIGATPIPCKNKLRRFRKLADDGWSGILQSCAGVEYETSLFVHKHVFVVSTPVSKEGSSDCPNLAMEQSDALANATDTGFGIRSVNVHEFTLPTGIDPRDLPHLSIGTFPLADIARAFDTVKAQVDSDPDSMKSYDIVMENCGDFPARMMSLLQVSFDPEMVQFLAKRLQKTYHTLAREIRANRNAANILAAKSTLTELTDLQLIELLVESKVKYLYSPSTRPLSDSYNDPSAQGHRLLLSKEQENEPAADARRLADVACGQWYSSSCLAENDIRYDSTASNAIADQNSAWKKFEGAYGPDGRVIEPAFMEEDAATFAPNQMPYSQAPYKMFINITLSGSRLYEQMHTIHPPPPEAFCNQIVPEGKQNVLLPGECGWSGTAGFYERFGTSTFEKDGSVTMLPFGSTMLGTELDRKSYVSLPAGDSNHFSSYLEGGVLVQYASACLDAECNQLSTTIYQYNTSTSSGEEYQFLASTRVFATRIASTQQFRDALESAYLEYNVPSDQRPFEDGCLSGYCPDEGDWCEYDPECAVSPYSEPEASVLAGPVVGVVLAVTVLIFLALFTLHRRQMNQKEAIVRTMFASRIAEGIKLHGGNDGSSSCLSPDELLAEFHKIDQDKGGSIDKEELWAFLNSGTTVGNMSRTDFDLLFSVIDFDQSGSVDFNEFVSFFAKCDKEGLKQQCYQVDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEA4</accession>
    <name>A0AAD2FEA4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000215">
        <property type="protein sequence ID" value="CAJ1932244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1932244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="105" mass="12288" checksum="14FE15BA554C05EC" modified="2024-05-29" version="1">MVTNAEQQTDSVKQQMQCWTADVSKIVDAKSTYINWGKEDIPHQMMFDFDDEDDEFMRNFGMLINPETLEDGDFEGLKKLQMTLMPKITPTWRLVYDEANSKGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF66</accession>
    <name>A0AAD2FF66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS5109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF66"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00421">
        <property type="entry name" value="intradiol_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF10">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042197151" description="CS domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="537"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1936273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="629" mass="70099" checksum="36ADF3F0D1174F4A" modified="2024-05-29" version="1">MSTFRFSWRFAVLVAFVCISSSLAQGLPFLIFNGKVENDIGEPIPGAQVQFWHTDTEGNYNHPNAGEIPLDPNFQYYGTATTDDSGDFQFLTRRPGIYLSRPVTHIHFKVWLDGADVFTSQFYFRDENTSFNEMLILDLVEATDMVGDSVIPTFSTNKTIVLDRGLGGSGPFTPRQGAGPFYPREDFFSLGSILIDITADEQPGTPEPSAAPVAPTIQTRAPSSSSPVSNDVFSTAPSVTTTTTDETSFSVISCQRKFLSINKHGANFFSFRIPKIKRLLTGKEATKIMTEEEKELTPEERMQWLRDRGILIETPEERKWQSEAEATKSSSSAPTETVSYVLVPADSNLPMQELTFESSQDVGGDGLLEHVKPTFAKDSKKVDLSLLQQPSPMQMGSSSPGNVSEDALKKVAQDGQVEIFNLVHPTPSNKFVGINIYLDEIGLLKRLPLNNRASDFARDVGYNPPPQFYGDVFLGRVHRRGAILIRNISFVLNDTIPNADWLQQGATQNLEYQMEMNQITGRQETQTEVAGSNGVASQEVGYTWTQTEEEVEVVAPLPNADIKTKDIKIKFKPRQIEIYCQGEKRLSFEIFEKVDVDGCTWTIDKVNGQSSIVVTMEKMDEALWPRIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFI8</accession>
    <name>A0AAD2FFI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000403">
        <property type="protein sequence ID" value="CAJ1934880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="33914" checksum="306F7B6E403E3400" modified="2024-05-29" version="1">MASSSSKSTNSPSMQDERETADKTWKFRFQELLDYRKEHGNTLVPQRHQQLGTWVSAQRKLYRLLQKGRHVPQLNDWKIQQLNDIDFIWFVGRNRDKILAQLMMEGKTPEKPKAMNKRQAIPHKPFVAPKKNKKQKTCNQTTRRRKARCQTRSSITQLQKKKIHPAVDESFLVQQQCTEDEDEELNDHDLELARLIANFTTTTTTTTTTTASHDTSTNVVLDDEEEERAVTNTMMQDYQEMNNYLNTIATLHDDIFSLQQELFQIKSTTEKLQNELVLHHHSKSSNDTTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFQ5</accession>
    <name>A0AAD2FFQ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aldehyde-alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">In the N-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1920803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07122">
        <property type="entry name" value="ALDH_F20_ACDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000001">
        <property type="entry name" value="Aldehyde-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000007">
        <property type="entry name" value="Aldehyde-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000002">
        <property type="entry name" value="Aldehyde-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012079">
        <property type="entry name" value="Bifunc_Ald-ADH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010378">
        <property type="entry name" value="PRK13805.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000111">
        <property type="entry name" value="ALDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="10">
        <location>
            <begin position="455"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="644"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1920803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="892" mass="97730" checksum="A7EF42868AAE692A" modified="2024-05-29" version="1">MSEFEELNALVDRVQAAQKVFATYTQEQVDKIFRAAALAAADARIPLAMMAAEESGMGVIEDKVIKNHFASEYIYNKYADFKSCGVLETDDEMGTMVLAEPIGTICGVVPCTNPTSTTIFKALICLKTRNGIVFSPHPRTKKSTAYTAKLVLEAAVKAGAPPDIIGCIAEPTLPLSQALMHHDGIDLILATGGPAMVKAAYSSAKPAIGVGAGNTPVVVDETADVKRVVSSILMSKTFDNGVVCASEQAVIVVDEIYEQVKERFSRYGGYFLNTEEKEKVRKILFKNGALNAQIVGQSAIKIAELADVLVPPYTKILIGEGAELSEQDEFAHEKLSPTLGMYRASDFNEAVEMAVKAVAMGGVGHTSCLYTNQDKNTERIEHFGRKMKTARILLNTPTSHGGIGDLYNFALAPSLTLGCGSWGGNSISENVGPKHLMNKKTVAKRAENMLWHKLPHSVYFRRGAMAVAMEDLKDFKRACIVTDKFLYNHTPYVHELTELLKARGIECQTFYEVQADPTLTTIRKGTDVLDNFVPDLIIAIGGGSPMDAAKMMWVLYEHPEVDFKELSLRFMDIRKRIFKFPKMGTKAKLVCIPTTSGTGSEVTPFAVVTDDATGQKYPLADYELTPHMAIVDANLVMQMPKGLTAAGGIDAVVHAMEAYVSVLANEFSDGQALQALKLLKAYLPRSYKNGADDPVAREKVHNAATVAGIAFANSFLGVCHSMAHKLGAEFHIPHGIANALLICNTIRFNATNMPTKQTAFSQYDRPNALRRYGEIAMHLGFTQEHTMDRVNAMLAWLDELKQELDIPLSIKEWGVDETEFLAKVDQLAVNAFDDQCTGANPRFPLISELRNVLLDSYYGRPYVEDYERGGMAKNLSCDSFTVLHHAAEQTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFT2</accession>
    <name>A0AAD2FFT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS979</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1922492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFT2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1922492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59295" checksum="3B80298B8BE8A6D5" modified="2024-05-29" version="1">MGNHSSKKLDKTGRMGIQQNAVQQTNDLDDAYDISEHSIGEGTRTSIKQGTSKKYTKTERSTGVAIKLYNGKAEVQPDLKLEAEILRECDHPNIVKLFEVAKVGKNLSLVMELCSGGPVLDRCPYTEKMASRVVRQICSAVAYLHSKQIVHRDIECSNIMYATEDKNSDIKLVDFGSATFLEMVPGHQGAFKFLHDKTGSMHVMAPEVIKQRYGPKVDVWSIGIVTYMLLQDGQPPIHGTTIDETERKILQGSVDYRGWSHSSLAKEFIQLCCHVNAGQRMGSAEARKHPWIEKTIAKKNLPNELVVSFDLFRLSSPLKRLGLNVLAKKKHASKYSGLWEDLDTSESGTLTRDEFMDGFKHSGSSQEELNDLFVKLDVNCNGEILYTEFLAATLENSGEIQESEIKEAFEVISKNGKYITKKDVLKVVGAKRKRKVDDASLKEEIDFIFEDTDKIDYEGFATLFEHGYTAQIGMDAIMETSLNEEQLSKMKEDDNVTHLSVVKESMTGNFDFDPSEEIRNSFRSGTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI84</accession>
    <name>A0AAD2FI84_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS7376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LEG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008499">
        <property type="entry name" value="Leg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18820">
        <property type="entry name" value="LEG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18820:SF1">
        <property type="entry name" value="PROTEIN LEG1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05612">
        <property type="entry name" value="Leg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1941147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="415" mass="47257" checksum="49B223E52A4B5447" modified="2024-05-29" version="1">MCLPTEEIPKQQQQQQQKSKKFELKAWQEGGISSFDQTCYADYWDDETIVPSIPISSSGDTMDPFDFGHRMALGKCLIRNTAGSKSNCWGEKNYSEKHWYWAYLAQLDWQWRTGRLSYSGGSTIAPKTTTNLPTTIISTAAWYGNMNANFSVAAYMGAMKANLVPSIKLDTWRKNIEEDPGFQICVEVWYEFWIGPHAKYLTTMESSAAASQEEQDAETKETLEREALIEVYRALWEAHTDIIHAGVEHNRQEEALLPEPERKFAMGWCHMVELFAAMGYTLLSLEALMVNGAGYLPSQVLLDESVLEHLKKNKPDEYQQTMQVMDLYNATSLQLDSMCGFFRRLTRWEWERQQMPITLKILNKGAVVPKTKLLLRILTKIIIPHPTKSTLMERSLFAAAAAVATGALFMKQSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKB0</accession>
    <name>A0AAD2FKB0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS9261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1945117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="662" mass="71883" checksum="6BBBDA67C6C749C9" modified="2024-05-29" version="1">MRRPRSSIRFMHHRVWILSLVILCFIVCYIEVDVVPKDEQHEDPERLRLLQRELQVIDDDDGISLRQTILPTLILTPAPTSPTGIPSTSPSNFPTIFSEAPSEPPSTSPSEQPSTSLSPSQYPSLSLQPSLSQRPSYSPSVMPSKTPTMRPTKSPTTMPSVEPSSLPTPSPSNTPTGSIGPSAQPSFEPTNFPTVSLRPSLMPSISAQPTTTREPTNLPSISPTLYPTASPSIMPTPLPPTQSPSGTPSQIPSLSPSLQPSTIPTMFPTLSVFPVVAPSVTMVLVGFPARLSDIQQEEWENMTSDHVLRFYQKFNEIDRGVIPVNVTNVTTVFLEQSYQPEDGRLEIEYEQTLVLGKFRETENDEVLFVAPFVENTQDYVIQLLTTWDFDNLIALRSVVVGKGNGTQAPAPADDTGISSGGLAALAVSIVLGACAVVGFLFWDKKEKWGFRRQSQQPPQPASPIREGVQESERMNGDREGRVHDSQGWRSGGRDGTFGSQGWTNTQPRTPPRYDSSTMPTAAMLSADGGSTIDRMSLATGSHHGRLQSRNTNVAPISMRTGVFGRVRDESEITVTDSDGGLASDTGSDGFVIDPPTLPSIADVAETFLPGTNVGALSPMHIPDEEEEAAHHEYSSSQEMLGLARPHSSPPVFGFSMTIQELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKF4</accession>
    <name>A0AAD2FKF4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKF4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="280" mass="31738" checksum="D77DB94AA575827F" modified="2024-05-29" version="1">MNILRKTNVSLPRLNICRKSSEPYSKDREDGIPSFIVCDPTKGFYGEDGEEQKIDGEESKVEEAHIVVAYTAQARNNEEQKSESVDGDSAKYSSLLQLLESDFGQDNQYGMQRLVMLANNEFVNSESKGSVAEALVFDIDTDSAERLRRSFLRHLNSENLRLAALRVLASTLELAKMQMRGTTEIKLDFTSRYFRALLEVLGAYNKEVEEIERAEATLSIKCLGVLLSLDQTSTIESYVRKTLLSYIQAAYHQACEANDRRLQRETKGMLSSLDIHWTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMM5</accession>
    <name>A0AAD2FMM5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001609">
        <property type="protein sequence ID" value="CAJ1946136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="14808" checksum="6923A8871FDA4712" modified="2024-05-29" version="1">MAASFHLEEDILDCLLDWYPRQILQRDRHGLRPMDYLLWNTASATTVSLIKMILRKTIVSTIASWRGGDKRQEELNARLDSILKVDDPVGDRIQHVHDFLEYAGYYVRLQPTFVLELTMWKWRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMY4</accession>
    <name>A0AAD2FMY4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS10747</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMY4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000204">
        <property type="entry name" value="Inositol-3-phosphate synthase 1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000055">
        <property type="entry name" value="Putative myo-inositol-1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="15">
        <location>
            <begin position="308"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1946606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="537" mass="59461" checksum="BDC0A25A0B5E5C74" modified="2024-05-29" version="1">MSSCNNLDGAFTVQSDKCKYTEDAIVSDYTYETTIVEGNVVKPVSTKMQFKTERKVPKVGVMLIGLGGNNGCTCVAGVIANKLGLKWNTKEGEKESNYWGSVMMASTVKLGNDAKGNSVYTPLKNMLPMVHPNNVVWGGWDINGMHLGGAMKRSNVLDYDLQQKLYPYMQDIKPLPSVYFPDFIAANQSERADNVLTGSKQQQMEQIRKDIQEFKKKNGLDKVMLLWTANTERFASIEEGVNDTAEDLLTSIQRDEPEISASTIFAVASILEGCTFINGSPQNTFVPGVVELARQKKVFIAGDDFKSGQTKMKSVLVDFLVSAGIKPVSIVSYNHLGNNDGKNLSAPSQFRSKEISKSNVVDDMVASNRILFEEDEHPDHVVVIKYVPYVGDSKRAMDEYTSEIFMGGTNTIVMHNTCEDSLLATPLIYDLVILGELCERIRMKKVDDSSDKDSEWEAFHPVLSLLSYMLKAPLVPNGAPVVNALFAQRQAIINVMRACLGLAPDHHMTLEHRFESSLQELAAQQGNGRPLKKARTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNE6</accession>
    <name>A0AAD2FNE6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNE6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="433" mass="48453" checksum="E06F2CA2A47CF9BD" modified="2024-05-29" version="1">MENVFIYRGGYQEVPRHVTRVYIDPSVDEIKNKAFKGCKELREVVFAKDGRLEVIGSFAFMGCESLELIELPKTTKRILCGAFINCSSAKLLILNHGLQEIGLSSFRGCRGLKYALVPRTVDHMAARAFFECTGLEQVAIEKGLTKIHESTFERCTALKMIGLPPSVTRIGSNAIPRETKQERKHWVWAVSQVSVSILKMNTNSGNCLSSQNDDTANLKEAPVPVSPRQPSQDSTASTLSASKSLTLSQEDDHAEMVNATASGNLVISREEWDDVNNRLEVAEENVKVLKAQLNTVPTQAKESLSDALCQKVNALEQKLNASVTRFDNDKESLQSELKTAITSLHQTTTERDELKEEIATMKQCLEALKKGFDLLIEKDQVKHKEIGQDTSYQSEQTKKRSRHDWEDSPVESLGVMGSIKKRILTWSQQNHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPB4</accession>
    <name>A0AAD2FPB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS11588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF8">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042119303" description="J domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="230"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1948381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="663" mass="75700" checksum="5E8DE3987CDBEC87" modified="2024-05-29" version="1">MKMILRHCLFFIIVGLHIVPRVSCQQQARRTASHRGSSSKPNNTRQDRQRRRRDDDFEDRRYGSRQDDSRRSSSDNRHDKTRQDSFWAEEETSTAIAKILRKTKPRGLIHGIWKASQSTTLGFLIGMTCLITFPSASLLLVGLQMKPLLLSTILGSVMGLSAISVGIWNGLYHCYWGLVQMPKSIQSWWKGSVWNPYDGGSWQMYNLWEHQQELQREQLRLSSSENDKPNYYQILEVPSSASKSEIKRAYYVKAKALHPDKNPVQSQEAEEAFLQLQKAYQTLSDEAQRSWYDEVGQTSSPAQDKIAAMFHPNLFFSILFDSNSLQPFVGNLAVSSWTLSLIQLGLFANEDDDDHDPQENVQRLIVMVADLQRKEQKRQVDVAMHLLATIETFTSSGSAGAGQEQIPDLAFRQYCKQQAKAILEKSLFRDARLLQLLGERLELAARQWEGKSPFGLVKKGWLWTKSSAGLLSHRLEFYKGIFGLLQYLLKYMDSIRQGDFSFMGEGEGQDGVKHDEAEAPSKEMVPKLWRLLWHYTTLDVQSTVDGASWKLLSDSSVNRSEQANRAKALRIMGQEFAKVAKENDGMMTAMMQPSGMNHHLGEEFDAEIIKNEDENLSFTFVTDPAMRLEIAMAVAKDQVGDSPIKLRKKVHDYLKQQEKTIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPP0</accession>
    <name>A0AAD2FPP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS11357</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="329"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1947885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="593" mass="66379" checksum="129C3AFF76CA9C11" modified="2024-05-29" version="1">MSDETSKKEEDANAVSVEPIRDAASSPRNETSQTGVALTQARRALWRGHPSPVLNPVLDPFRTFVLDPTLAIQSVLLPLLLPRSIDSIFAKGCRNVGIPILKWLYPNTVITNRNNNKNGETSMKDATKSAIFQPTIVTVRPPSDFQSAFQGAISFVVSAIADVAGILTNPKKLTGWMQALSQFNTFLESTGVGAELEEAIQKPLLAGRLLDNFKLLNDIQEQHYGNRVELAQQDDIKSRGLGFAQDIERGHRMMRFATAAYGTEMIRSAVDQNIDASEYLLDHVKAIAVHTQIPHEDIQFVYSGNENDYDAHVLHHFVALDRPNKSIILAIRGTLSLSGAIVDVQGMASEFCSGKAHKGISEMANNLWNESGTKIQQLMDQYSDYKLIITGHSLGGGTSCLLNLKLHVEQIFAPSRKIECFAFAPPPTFFSCREDPTIQARVEKAIQNTVAYLHDNDVVPFLSIKAIRRMVTLLDAVDNETELIWFWRRWRMFYEYAPIPESIITSVLAVEQDMHRGKLLAEEVDGEHNMTIPARRVIWCKHNITENRFEAYSCDPEKIARGNIFLTPDMLSDHMPEMYEDALDAVLASINER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS56</accession>
    <name>A0AAD2FS56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS56"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="42"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="475" mass="53364" checksum="EEE14259C04A954F" modified="2024-05-29" version="1">MTIIDPKDLSNLYFGANKKTNAGEETAEFFVHPSIAIQSGTESTTPSDHHGTNIVHGRGMVATNDIAAGECIFITPPTVGMDCHAMESKFKSGTNVALEDLAMEELIDKMMKDINSKQDGDTKVNACINSFLCLMGSTKDTKKKVTIQMLNGKDDTDHWSAEELKDLSRKDMKTILLKNAFGPDFIMYDRIQAQWSSNLSYTPPNILGVFPLAAMINHSCTPNAVRTFSNSCMVAHACQTIPAGKEIMWSYIPPTQVMADRRRALKKRHGFLCKCERCMIEAKELRKDLLPTNLKQALEEANKWNEGMLDMSQISDETSKRQLCAAAIHLEETIFSSKSLSNEVKRHVRVGYTNLHINYFNTMLTTAANRKQPQQQQNVQDLVLQSATQLHFAYCSSNNTSTEHLSVLHLCYELASSSKNNNNNAKFWTEAIKRAHLTRYGSLGSNLTSIRNCMVHTRTVLRQRDGYLQVQFNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSN9</accession>
    <name>A0AAD2FSN9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cathepsin propeptide inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSN9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="680"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="466"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1951836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="737" mass="78699" checksum="A2F5B9EE32A283FE" modified="2024-05-29" version="1">MRVSLAVLAASLASNQHNAILVSAFQPPTDLNHQHPPNTEQQQQDPNHPRQSTRLNDASAMPYDASAVPYLSNWKLLPEGNIQGVIFGHPVLENGDVVTTSQIKDLKNPSENQIIQTESGSHYLLRDRDVDETRNNFNHKVAGPLLGGAVFAAGAVGLVMDGESARFDTAAPAQAFKEMSAVSIKQFQNSAQSVEESIDLPYLASKVSEAEKQFQAARENMFQNSAQSLGESINLPYLASQVTEAEKQFQAARENMFKQKGPESNAAAASVVAKQQDTQKFEQALSVAAEKVAVEKAALTEKVAWEKFVQNEIAKEKADTEVISSASSAAAKALSENKFDEAKAAFEKAQMARADLKELQAERESATLAEENAEAEEMFAEQDVMKIIREIRQMATMYTAKAASLKPADALYYLEELKINPKLAEYMSTEERQVALGALAAAAATGTALAGSSFASGKKEDEKEVTSTSPMESSTTTKKMTTPPKQATSASPVASSSTKKKAPEPARAQSAPAVVAAKSTATHAASAASSTAASSTAATKSTWGSYLDVLGSYGCGSSVVPSSYSPFGKKSTGMTSHTSLYGPPIAEHASPVAAAPTHTTAAATAATTTTTRSPTAHAPAQEKPRSSGNSGYLDALSGPPGAAVMTSYSPFAPKKSQVSPPTKPDIPEKPDIPAHIRLAYKEWCEYYGKKNEEFRLEVFAQNFADAKEFYKESGRALLLNEYADLTAKEYQLLPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT58</accession>
    <name>A0AAD2FT58_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001804">
        <property type="protein sequence ID" value="CAJ1952564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="803" mass="89339" checksum="3C323295A37C2AAF" modified="2024-05-29" version="1">MVRIGQRELQALNIDTNTTQLPATSTTQPSGTRVTMSTAGNSTTNRNPSQVLQPGHLEHSLVHILETVFGYSAGSILHLALDLHGCKCYLALVGMDDADIDGLQYPVSQPCDANGDPQPHVLWDVPKPLKAYLHGIHGYIYHRETVLKDPVTLTNCILIDPDDFDTYRASSAFIVFRSRTIPQPLVSTPSRRSPAEEFDRGIDLDAILYPTLSNSRQWDSHHGKRLTSEEEHPQYPSLAEPFVPDLASVDLGPEGKHGTLDKENSQYPLDLEPDPIVDPENKSRHGTLDNDHVQYPCLVEPVATDLASVDLEPDPLAYRACLASLATLPCKTSLCTAKLEAAGSNNQPPAQPPPSPQHSVNLHEMSATTNFLSQFQHSSMGRSEDADTLTSVTSEETKSDKLALVQATKYRKATQEVKNYEIAIDGVDVDEWAKSVPDDGSAGEQSPFDRVDILTKSNTTVTTLKDSPALDDAIGFFETHHCVMPTNGLYKLHPGQASDLDWLECNMAGLFDLDPVHVPQLRPPDFEAYKSGRQPSVLFVPETPINFVIDSTPLGDKPIDLTCKLSSSEPRHSPPDEGYVRGAKIIELNYKHNRNRDIQPARIQLCLNINSGEYECVMAYHNIHKWSEIGADNPIDWKLKRNTPEPLSITGADDSVTYTIHARNHNLLESQGCNLLGNIVKDKKKLLCPTNQVKLRLLHTTSPKYMYYYKIQKDHNGVLQLDKLHGNTNCKHATKVKIDLLARYKVLVDMGRGIPTPKDHQKFQVPHVNAIKHCDKHKPRLLPYGDFTYIPPNKTKPYCLLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT78</accession>
    <name>A0AAD2FT78_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001779">
        <property type="protein sequence ID" value="CAJ1951084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="129" mass="13913" checksum="1368560A9FDD7D94" modified="2024-05-29" version="1">MHSSIKRDQNHPNTHGCQGQQEVASAVFQEVVDTYNGTRPTLANMMKYGGILSDTIDIQGVSYGPGENLDKCHANLPENPMMQSECCSCNTMQGENPHYASDQGAFNGRCLEQTVNASDSVAYAAAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTF2</accession>
    <name>A0AAD2FTF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001808">
        <property type="protein sequence ID" value="CAJ1952616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="260" mass="29924" checksum="B0FDFD2CEA712D15" modified="2024-05-29" version="1">MKDRVIRRILGPEVDIFCDLDPSLREFVTVVKGKEVLYVQLDRALYGCVKSLMLWYALYSETLMDMGFKLNPYDLCVANCDIDGKQCTICWYVDDNKIGHMKLEVVKDIIGKIEAKFGKMTLFGEEHEFLGMKITYKDGKVEISMKKHIQKAIDMFMDDINREATSPAKAYLFDVREAAKDLNEERADNFHSVTASLLFVLRRCRLDIQTAIGYLYTRVGCPDEDDWVKLKRVLQYLKGSIDLTRIIGGDGGFFHQTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU63</accession>
    <name>A0AAD2FU63_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS13906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001822">
        <property type="protein sequence ID" value="CAJ1953176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1953176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="349" mass="38443" checksum="7D392E0AF858D7DA" modified="2024-05-29" version="1">MRETDPAAFKAIVHHATSEALIKAQALGFSGHPPVVDNIQTELGDSFVGIIPVLMKAFKVLLVLMAFFLSSLFLYGLSYVAIMPGSVSVQKLYFDYSGIASHPVSNQIFPETHFRKTLPHILDNAPWAVADFFSKHSQWEAYNDDTIPAPRTSNRVLKPGGMYQVEVILDLPQSDINIMSGVFSVLVEILSVDGTMLASSVRSTRIPHETGWVSTIRKGVLLAPLLVGAAEETRTVKVPSFRYLVENEEMPLRYATVTLLSQENKPIEVMTGSILIGEELSSIQLLMKEWFFTCCAAGTAFIFCTHGITYLGFMAFLERQDRPRGDELSLDSGSDVVSQGNSGEDQVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUI2</accession>
    <name>A0AAD2FUI2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA methylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010719">
        <property type="entry name" value="MnmM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35276">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35276:SF1">
        <property type="entry name" value="TRNA (MNM(5)S(2)U34)-METHYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06962">
        <property type="entry name" value="rRNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="49160" checksum="037A41FC7F747E62" modified="2024-05-29" version="1">MLSTSKTIILTATITIASMLFASKVSAFLHHHSHMQHRCGRFSSSLATDTRRRIWNPLGSSSSSSSNNNVDVYKQEFNSNSQTINKNAMFEGLLSSALNRAQSTLEQTREFSSTSSSTSSSFSTPTAFDQQPPTQEQPKKENSKKTSKGSYRDNPAITNTALAHSLWREILKPNQDSAIDATCGNGHDTLAMAEILFPSADHEDNNKHENYSQLLALDIQERACQSTTKAIRERFGPSILEEDHRVEVRQTSHAPLPTPSDGGDVGLIVYNLGWLPNANHNNNNNNNNNKNGKKAATTTSSSNKDCITKVESTLQSLTDAALMIRIGGMISVTTYPATNEEEDLAVRVLLECLALLSSNVQTWRGFLDEIYDDTVVHDDDDDESDDEKLQPSKSQLSKETMEMIVVAMERIVSEGEAKQTFRVSEHRKLGMYRAPILLTATRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUP1</accession>
    <name>A0AAD2FUP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="274"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="500" mass="56584" checksum="3E095AC5B5C55285" modified="2024-05-29" version="1">MSDDEYSYEYDDDDNFEYTDEEEEQDDAEVALENAYYNSKGLRETDLTEAAEAFEKVITQEMEEQSSNGGKKYGQWSFKSMKQLVKLHLRTGNADVMMRHYNRLLECIAEGDVNPNAIEKGINGMLERVSSLYQGAGARITTENMDPQRLALAVYDATLKVFHPTSGSCSNERLWFKTNLKYGQLLYEMNETVKLQKVLKDLKSVQQGSGDSSTGGSSTQSMEVYALQIQLYSRQKDNKRLRDCFHRAMAVRGGIPHPRTLALIQELGGKMHMAAKEYEAAGKTFFQAFKSYDEAGDPSRLRCLKYLVLASMLYASSINPFDSQEARPYRDDPEITAMTSLVQAFHNNEIHKFERILKQNKGRIMEDEFIRDYVEDLLRTIRTQVLRQVIRPYTRISLLAIAQELNNIPVDDVEMLLVSLILDGTLDGQIDQVAGVLVKKAERGNGKTSDQGRTTQTEEDVVKAKYMAMNQLAKALESISGSVTSARMKGESTPMRGMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVW8</accession>
    <name>A0AAD2FVW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS15026</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000033">
        <property type="entry name" value="Phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="231"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1954434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="502" mass="56927" checksum="A75C00BD568D8FBC" modified="2024-05-29" version="1">MTEVSESKILGHLSTAAHASIDDTFPWAASEKIDHEAVVGTIKSLMADEFVKVDNLSTSFYSLTGEGETILAEGSQEYKVLKALEDAPLSLKDLEAKVGKNIAKIGMGNCMKKKWIKKDGGNLLALKKSSEVSDEVQDMLKKLKAADFAKDAISDKEFKDLKKRKMANLVTRKSFKVERGPKYAPQRVKKSADLTKEMLESGAWKTAEFKPYNFLTLGEKVGGGYLHPLLKVRAEFRKILMEMGFHEMPTNKWVESSFWNFDSLFQPQSHPARDAHDTFFIKEPGATVSVPEEYYERVKKMHEVGGAGSIGYRYDFKKEEAFKNLLRTHTTAVSSQMLYKLANQPGGFKPARYYSIDRVFRNETMDATHLCEFHQVEGLVADYDLSLGDLIGTIETFFKKIGITQLRFKPAFNPYTEPSMEIFGYHPDLKKWTEIGNSGMFRPEMLAPMGLPENVRVIAWGLSLERPTMIKYRIKNIRDLFGHKVEMARTRTAPICRFDAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWF3</accession>
    <name>A0AAD2FWF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="131" mass="15221" checksum="C79AB3DCAA378319" modified="2024-05-29" version="1">MIILDGPKLFDRVSKVGFESWKHDMHGMITDYLFVNCTHGWPCGEKEIVFRTCIIKSLVKYERMVVASLLELMAWKLNCLHLNGSGKFQTMQGILDQSAIDESFDPVEYKHQCRFSSNVGVIMERLLEFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWV1</accession>
    <name>A0AAD2FWV1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001879">
        <property type="protein sequence ID" value="CAJ1955060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWV1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="497" mass="55839" checksum="91A7136658EAF352" modified="2024-05-29" version="1">MTSDNKTIAGGSKKRPVSGASDNKNNDQSSLKQSKLSCPPADDKTLGNCIETIKDEKECFHERVTDDEKETFKYMMIKTLGQNEDFFKPTQSILMVDLAHFLKTGETEVIVAGTEATALQRVASIEFDINASKMVYKRDLTAFVDEVKNLFDWLEKGSKVYMAPCFPLLQSSGAGKTKLLHKSRCSMAKNDPDVHMKLICTNGKSPPEMSSQNGSIFSKTLDVSQFQVDEEGQKKLWEKMVALVKTEKEKKKKVVFLFDESQHLTSSCDGWHFRCIRWWLRLVCIFVCVPTTTSLKYGGPLFGRLQLNGKLKDALGHILLRIRGAGQELSLQKYYSLLATRLQMGQVLLDFASELVALGYAHLTHYSQEQTAVAEIAFGNLYEYVDGISLGCGKPPSVWSEKAIKIYSSALCRPKKGDVGEVAAAFYMLACGDELRFEHSRDLTQLSVPRENWIARMQQSKGAKLCKSTAKPSVNFIQVCRNYLRYSLKEIEDSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXM7</accession>
    <name>A0AAD2FXM7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001905">
        <property type="protein sequence ID" value="CAJ1956186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXM7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="221" mass="25124" checksum="8BB00BB55809A28A" modified="2024-05-29" version="1">MQCDENATCDDNESGDSNTQWNYGRSNNGSHGEQLIQEGHTDNDSRPQGIMLFQLNNTGINLDSASNVEGRELYQEGIDKVFDSVCKLHTRASNNINSLLNMVKDRFDVFMDTKRENSFFVTRNGTTWQFGHCNGLYTLVGKPAVATAMFHNHACGLDNAGVDPCFDIEIERHKGMASILQHDRIDGGEAMDEYHGLWKWTKFAQWCCELAKNRRWDFDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY06</accession>
    <name>A0AAD2FY06_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="230" mass="25634" checksum="61825620E37BB1C6" modified="2024-05-29" version="1">MLDGSLQNSPRQFNVRWEASWISPNSVWLYELAEQVGWTIETKPPDSTKVSTFSWLRVFQLFQNAFQTGTIVLPRYSVKGNTRFRLIQDGSATQAVTIILEESIDLVEEADSLRLQNRVVAQEFASWLDVSRKPPIADEVDWASKVRQRILTNVPGAGALDVDPNEDEPGVLYTFLILCITCTGILYQTISGEMMGSQGQVSAQCTEAEQLVMGSGYLTECFINGNGPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY90</accession>
    <name>A0AAD2FY90_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="332" mass="36855" checksum="4BDEF50906084971" modified="2024-05-29" version="1">MTLLKKLVCKSVKEELYCDGNNYERRFDQASSYVQGYGRSARRDPRKMSRQQSRPTNHNNNNTAQKQSNQKRRRNKSKGRQMQIPGAIPEQTGISYRHPEFEELEADDFVVNAVRKSLNHGKSKKGRRGLFQRGDADSVSTASSVTIDLYGTGNPQYYYGEDGDESDVVSQEGRGLRLAPAPLSKPLIMTTPNYQKESADEDEAEGYLDQCMGMMADLLVGESAVPREATKQNRIANGEPAAAAAAAANVEEKYNDEANHHHHHHHHHDETATTITPDYDLQSLAGESDAFKSVSSQNTYTDESSRDSYSTGNSSYEGSEATSELENGLFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZT9</accession>
    <name>A0AAD2FZT9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS17220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM151 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZT9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026767">
        <property type="entry name" value="Tmem151"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14857">
        <property type="entry name" value="TMEM151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1958526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="424" mass="48528" checksum="E093BFD91A7E08B7" modified="2024-05-29" version="1">MLEGNYAGISDESHAAMLGRVEASIMGESALIDRETGRVYWEGGSGSTTLFESFGPKMDQYGLDHAQTALFTGLITLAFLGVLAGWMRQLLDQWALNTNTQSAPMNLMFRIVTWTILRLPRIENRWLVIASIALYLIESYCCGTRYYLANALSSQEELEEYINQLRIENPVVTWNVSSFHFEKRKIFALSDFLRSLKRKLSWQADAVDMVLAHKNRKSMFPFTKKVVTHRATATYQYNGCLDSTMAGIWRRARIMSTNNAPFAKIALTVLLVLADKKSREDYFRQQSDFVSEHGRGDEFTEFATQIQVKGCKPCILAVRPVDGVMSTRLFRLQSFWFCTFLGLTLPYRIWFKRRCDFLRLTIVKETSSYTKPGSSSRGWFSKTQPAKSHFQSFMQRQSLYTSGVALKEIDSVETTARPEDNEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0J9</accession>
    <name>A0AAD2G0J9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0J9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="262" mass="30156" checksum="1AF60AFFAC863CA7" modified="2024-05-29" version="1">MTTITPPSQPNKLHVLVIAHPDDESMFFIPTIQALRQAGETLWILCLTTGDYDGLGQQRAKEMQQASKLLGFEKCIIRSDNKTTIQDHPSQRWKISDVSQAIETALAAEEHQASISNYQALVLITFDDMGVSGHVNHIDTYLGVQQFLISSTSPRLPKMLEAWQLESESNPIRKYIPMLSWIYLLLSLIFSQYRNISIQSKDTQCRIYRCHEPNLNWNAMATHHSQFVWYRRLFVVFSCYTYANVLRKMESTTTFTTAKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0X7</accession>
    <name>A0AAD2G0X7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Actin-related protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS17823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0X7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1959401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="52195" checksum="16A700472753A185" modified="2024-05-29" version="1">MYCGDETGSFIGEIGSHTCRFGYGGEDNPKYVAPSYVSDKKRMASSCLTARAASQDLESILRMPESLGNEPLLDPDAFLRQGDSVQDWDNLQVAWNEGMDTLRAKDTQKHTKGGTPYSTTVKKHKTIEGKCIHPILAIMPGFTHFEGYGPKYSASMKREQYAKYMEIVMEHLEATSLFLAPSPMLAAFSVGRQNALVVDVGAGGCRVTPVIDGHILQHSQRRNGRGGDWMGHVAWKAMLEQELPVIPRYKLRQKGCIAKSPSFHNWAVQDLMYELRTDPNVSVAPMDEAPSRTLFTNYDAAEAPTSPASGEEATPSTFELPDGTPIDLSTPFGKDVTRIPELLFSETMPFSSQSSSSSSSSELQTLSNAPLHHLIRESLLAVGDVDARKDLVGSICLSGASSVFPNMESRLSAELSALLPGFVKPKVVASRNSVERRYAPWIGASILTSLGSFQQLWMSRSEYFEYGAAMGVQRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0Y1</accession>
    <name>A0AAD2G0Y1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001993">
        <property type="protein sequence ID" value="CAJ1959423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0Y1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="387" mass="43771" checksum="EC5FE6B64543283B" modified="2024-05-29" version="1">MIFFPEGYEPTNKDILCGRGKGNLRHEGNQHFMEIIRANLERYNNAPKRIDKSLVVSLIVSSLKDDGYKFVRQDTKSRMWFQLSEPQVHEKAGHAIRDILKKGGNAVQQQSQSKQAINTSNNFDSAQTNEPDIVASQILSTALKVSKLVEKSKLDFTALSCSQTMAPDYVASSDPQRRNSREYRRSSIVRLFDELSPEEPADALSSGGFMNDQPLPIDARNSGALRTSDMMQVFESLANSTSDAPHHQRQQQGEEEEESIITPRSKRMGSSSREFRRSELLQFLDFNEDELMEPEEQAKGTPSTDQPLSMDSRTSDTLNSLFKDQEDIFSNLQNVFGSLPDAANADQSPQEMEERNSRASQVLSELLKRQEGIFEELQNFEAEFDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1X0</accession>
    <name>A0AAD2G1X0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1X0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="878"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="735"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1015" mass="109068" checksum="6CDA26FA1D6CACA7" modified="2024-05-29" version="1">MTEEAASSADTGVTKNDDSKSHENSEVTKRNRSKRRTASPNSGSKNHSHHKARDRVSPHRNSPRPSKSPMRTKDKVQVVGDLKSNHEKYDDSGKDRNQRSNSSNAQEREKRQERDRRSKRTEDQDKEAKGRVKRSNRAPALAPGAVSSDAPHPSSSKKSSSRRSDRTDDRDIKRKAARKTFALAPGAIAEEYNPDDGSLDDLSRSRRSADDPKGKERRSRKDRPIVPGAVSANEGEGSSDGRESRRRRKEKEASKSSGGAVRQKGAPIRTKKDALYLEDGDDDNAPASNTLEVVPEAMMVEIPDDGEDTKVKEFDIQGNPVMPPPPPPPESNIPHATHQNDGNHVSSPAKPYYTSPKFWVLILLILGGAGAAVYFFTKGNATEPVAIPGVDTTITDLPTPSPTTSISSGLPSTSPTDVLEIKPPTPEDCLAVSRGEPVEVRQDLIRNLQVPMDILLSEPADSEAVAAQLERAIQESLVPEMMGCDLIGAASRRNNMRRGTRLEEPRRYLQLSSDYSIGNAKTTVTPNEAACTATDEEPCLHVIVSIVVYLKGPERAINLQNWIQQVFGEGDELMAKLSLEAPIQAVFVFIVEILQNTLAPSALPSFVPSVAPSALPSATPSTDSPSNDPTLAPVVGPTTPEPTIAPSIAPSANPSSLPTPGPTVQPTLDPSETPSSSPTPRPTTGNPTPPPTPPPTGMGSATPSIYPTVIPSSQPSRTPTLTPTSGPTNLPTNEPSKTPTGRPTTSPSSAPSTPAPSSTPDRNCGPLWGGSKCSCNGIYIYCHAASGTCGDTAYYKNSQGTDWDCPNAPDIPGRCGPLFGGRACDCGSLLKWCNEDNGWCGNTVAHRDMQSSITYDCPADYPPSGGSSTCKYANNLKYGQIKPMSNTNLCLRSPNPRGGTNLEMATCNPFDNNQFWAYDSSTRRIQCLAAWNGVDTQCIDPEGPSLNPGTALQTWSCGTSIQSQHRWAISTAWQIESKWLSYATGCLDLGETYPQIQTCNAGDSGQVLAMGWYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G226</accession>
    <name>A0AAD2G226_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS18419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1960002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G226"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1960002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="552" mass="62409" checksum="DCBCB079F9453282" modified="2024-05-29" version="1">MPKFPRRLFELLKLTEEKGWEGIFSWVNDGTGFKVHDREKFETVLLQKHFNTKRYASFARQLHAYGFDCVRTGRNTGIYSHPQFKRDDPKGSANLKRKMGKNVSKETIHGVHKQEFQPGGGGIRNFVLAGDTIVLVPSLLETSSESDDSSQNSSSVMSNLYNTMRSQVVHQTKKALIRIPSGATTIQQHDDLPFGNHRINGKTGSWSGITTAGGGGSMNNDNNMNVPSRMHMIADDASAQGSQHFDDLEPVPMRTSAENSTGNGSMLLFQKEDFEPIPWSPLHSSDAFHSSDDDDDYDEDEDDAIPPNQLEPSLEPRTINEMVEHPSSANTWMYDSIPIFATPRQRALVELSFPMVLPLGFYVLNVSTYGICWITLLLVGHFVECMFTWWGGADDKKDKTYTEDLSIKPTIGMLQHHIMDLMWIHSLLSNMVLTPHYFGPSCFALFYLFIGLQPVNLVIVIKTHYCESNLEGTYTHEKWWIGDIVKKVFIGYTLTTLGVFFMHFYNMNFLRIPIVFGFNMIPLFAFESYRYLLSAPLTLLGLGVVSHAKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2E6</accession>
    <name>A0AAD2G2E6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS18546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2E6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001717">
        <property type="entry name" value="ATPase family AAA domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021911">
        <property type="entry name" value="ATAD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF12">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12037">
        <property type="entry name" value="ATAD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="329"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="80"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1960130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="569" mass="63536" checksum="93236E985BF14131" modified="2024-05-29" version="1">MFGGGRKNEKPSDAIKPENAPKKGGGGSVTGFDPEGLERAAKAARELDGSRNASAAIELIKSQEATKQHEHAAKRAEMDAYAQQTRAQNIEREAEEARKTLDAQTQHERHRAEYMDELERKRQVDMLNAQKYMQEEQLKKQEEMVARQEEMRRKTADHEAALRTKTELAKAKAEADGRIRQERENHDLIVAKLKAEAIEKRDTVLKGIADAGKMVGEGLQTYLDDTTKLRNTAFTVTGIAVGVYTARTSIGIAGRFVESRLGKPSLVRETSRFTASQLVREPVKTFKHTFGIGRSETDALNGIVLENSLESQLRKIAVSTANTKKNRAPFRHLLLHGPPGTGKTMFARGLAQHSGLDYAVLTGGDIAPLGRDAVTELHKLFDWAKTSRKGLLLFVDEADAFLQSRETTKISEDQRNALNAFLFRTGTESDQFMMVYASNQPSQFDPAIMDRIDEMVEFGLPSTEERRKMIAMYIDKYLLKPPTWAKAVQTEDIGEVEIEKVVQETEGFSGRAISKLAIAWQAAAYGTEGAVLDKATFFQTVEQHKRSMSTKEVWLKDAEFRAEQLTIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2W9</accession>
    <name>A0AAD2G2W9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2W9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1958278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="195" mass="22087" checksum="77BFE626B368B0E3" modified="2024-05-29" version="1">MRKDVECTFGIMKGRFRILKTGIPLHGIEVCDRIWLTCCALHNFLLAEDGLDEGWNASRYLGGEDGDHDRDDICDLFGTALPQIPPRVVEDMLTHDSSGMGVDIDRTNKESDDSDDNDEDNDDDNGDAMDFMAIDDETVAVPAAIPVCTLSLKSFRRKLIQHFDILWHRHEIYWPSRTGDKPPPPINKPNERYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G385</accession>
    <name>A0AAD2G385_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS18814</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G385"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1960628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="446" mass="50449" checksum="E8C3426B08E11436" modified="2024-05-29" version="1">MPKTDPKACVICAKSSSLVCGKCKTMKYCSRDCQKQHWKLHKKTCGKPVFVDRNLEVGDKCTRCLETVEDDGHGNPVLMGCRVPHPEHLQQSCGSCYGGDGVTLALMCQACNYSYRRTGSGLSAKSETKITQGPKWCFEGFHTLLPAERLGDRRIKKDLVVITANDDMQEKIDALDGNEEVTVLRICSDGFYTEEYAPCLNIKLPNLIEFQLEDVSMKQIHLTPELTPKVKIISMQNPTQDDDPDFVIKCPELKDFTCHYWGFGNPDWVNTMLAHATKLESFDSYKLRVPYLKFASNELDNIRLHRAECLEYLELYAPRLTMLNVQAAYDLDVIKFVDTHPVLSKKLPKDFDFEEELEVNVENACLGEEAKHAIWLHPRFDGDEEDVGIEMGRVNISFRDGDVDDAIVTYDGSGDSKDASLYVPGDNPMLDFFHQLNERGRAGEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3G9</accession>
    <name>A0AAD2G3G9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3G9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="395" mass="41774" checksum="14BCD2BBA7CA80FA" modified="2024-05-29" version="1">MDKENPTQPTVAAVGASEEEGTKISKSARRRQRRKLMKKQIEARKLTEQTGKKGGAAAENSKPQNVPKAGSQYAPQNAAPNEGTQAASTTPTTPGSGKKKKKRNNKKNSQSPNNGAQNSNGNEFKEDKASIESTPVKETAAPKSEEKSQAPNGKQQAKRNAKKKNKTDQAQSKTGSSPAPVANEATKPKQPNPKNGKKAQNGKKPEKLPTIPSKPGAGEEKPKDNKPSQTKAAPKASNGQSQKSNKTEAKSNSQPKKADTTAPAGTAPKATNGQSQKLNKMEAKSNSQPKKPDTSAPTEKKSPKKQNKRKSNPQAVKKTEKATSEKAATASKKPEVKNSVPTATASVEPEVKTGVPTVSSKSLDTAASVSRSIDAYSDEQPPKDEKCECNACVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3J4</accession>
    <name>A0AAD2G3J4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mechanosensitive ion channel MscS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3J4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF1">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="3">
        <location>
            <begin position="745"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1961497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="952" mass="105959" checksum="0F2F927D2EC06D23" modified="2024-05-29" version="1">MNQEDGTNKLRASKVIPSLGGAATSSMDSTAKAAEQSLNDGLQTDAAEYYLLESLEEKGRRTIPNGDGFRPAVEGERAPLGLNTLGRAFDEEAPVATSSAPRFRNMAQLARQRSQRSFQSADEQQTNGNLSNSIPLNNQKRVQSLLESINDNEEENFNSMEGDGLFRGAPMEIDVDESRDPLFDETIDDYSSAQHQRLLAARRNGPRPRFQWNLACLNPLEFIKVLLQVTLVPFFVWAVPLFIISWILFEYAGNPELDFMPGEATVSWWLSFFGQHVILLQLSYILQALLIDCIILSTRLVSVIVGPWAALFCLQSRGWPFLVGCWGILAMVFLHGDDAFSQHWLYFTGMKIFTASNSGSYIIASNAYLRVLIGMVLAGAITSLKRTFVTLYFGKRSFDIYKTKLEKLLNKVILVSEVAELSAAASDIPLTDSKRSDATPVSDRRSGLGLGVRWASLRFEDGKTMKNAPGDVIQEKDDLDNDEDGEDDDSDGSDSSYDSDRAGIKKGGRKQDKGKEIEDQINSDRRANRTPFTKSYSTLSLDTSVKHFKIKNLLGRWDDPLNKMDTGSNSSVSDILKFRKALTYMDLEHPFSDSFGPAATRDELLTSSQAVYSRLRQLAEGSSILPFSVLAVLAENDDGTIDKQKQKSLKKTFPPDRSGNVSLLAFVSGCDSVYKKLRYFRASVGNASVIDKVLENIVDTVFFFGLTVLILALLNLNPWPLLVSTTTLLVTFAFAVGPSAQTAIEGMILIVGRRPYDIGDRIIISDSPGGSPPGVGESWFVEDITLFSTTLRFGHTNEVATVSNGSISQARITNCARSKNANVRLEMRFHIRLHEGSNLSDFREALDAYVLNNPNRWNSINYFRCQEIDTDNEFLTYRLVTRSTQSWQPASRVLEHRAQLHRFCLDLAIKMGVQYEAPILARVVYNGGEMLDASDPKVNRARDRQESIGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3T0</accession>
    <name>A0AAD2G3T0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS19362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3T0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1961769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="422" mass="47054" checksum="4F73CD3B2BBF5D3B" modified="2024-05-29" version="1">MIIQRLFYVGLCCQLFGESRGFLVQNPRSSPAAVSSCKQHGTSSPLQHADTDTATFNNLFSEFENDLNRLSQLRPPLPSSDPSLHATLISAGSSYTRLWTASTWVQHSRPPHSRYARHIWRWRHSSTAKKVLPAVLISTAWATLVSVSPHYFKWSEQILASAGSVAAATSVLLAPLALLLTLRANCSLGRLLEARLLWGRMVLHTRTLASLMQVYLLPHAPKTTLAAARLLAILSWQLKAYVRGESVELQREALNTTLDKETVDWILDETQQPYQKSIVTIPSRIRQLCHAAMNHMEQEKQPNIPQYQVENEICKLEEVVGGCERLHSSPIPPTYSRHLSRVMALFNLTFPISLVSAGVNPFGVIVVSMIASYVFIGIDEVGMEIENAFQLLPLQQLAAASQKAVLDQFLFMRNGPPLVTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6X1</accession>
    <name>A0AAD2G6X1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6X1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF3">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041953032" description="Peptidase M12B domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="4">
        <location>
            <begin position="191"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1965169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="784" mass="85099" checksum="B6232C2C1388CBE5" modified="2024-05-29" version="1">MKLFVTLLLFTFSACYAASIRGYIKDKEFSKLRAKDRLVDSFQPKLQNLCTSGNTFKLGDDCEVSFAMKDLEPTSGKHVFKSHACGDEDTIIVTMNLNDKMPSHAARLNQGSMQWTELIAMPHLEEHGCIYTTIANIDVDPEKKTKRRFRGDAKKRSHGQRKLNSTSTIDADITPMQHADRQLQQACSEYKVIRLAVRYDSRFCAEVGNGTPEGAVAFGNTIIELMNPFFNVAPLCMKVELCSIEGSCSANADPYRNMLDNGNTVCDDNDSTALLDNFRGLFNPRPPQGCDSTHLFFGGDPYPTDAAGCAYLAALCDDYSVGVNSISNGFPLIEHVLLVTHELGHSLGAEHVLGEDQYIMSYGDRPDSFKQENINRMTSYVDEVKAQDSTCTARETAGPPTVAPTSAPCAGSEFRLVLQTDEYGEETSWDVTGSNGVTIAQGNGYGSNSKFEIDDCLPSGTDYTFTIRDTYDDGICCEYGAGNYELYVDGSLVYSSNGQFEGEEVVPLPGGNNNSPPTPAPTPNPTPVPTNAPTPGPTPNPTPAPIPNSTPPPTPNPTPGPSPGPTPAPTDEWGEELSWQVEDPSGNVVVQGDNYPSGENFIEVTECLQSDGVHIFRIMDSYGDGMCCGAYYKLWYDENLVIAHDGQYANGESVTVPGGQVNQAPSGSPNQAPVASPTVGSCNHEFRLQLQTDEWGEEVSWELEDPNGNIVVQGGDYPSGENFVDTTECLSSDGVHTFKIMDSYGDGMVGDAYYKLWYDGNVVIFHDGQYGYGESVSVPGGNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G701</accession>
    <name>A0AAD2G701_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS20900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G701"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028:SF0">
        <property type="entry name" value="PROTEIN ALUMINUM SENSITIVE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="UPF0014 INNER MEMBRANE PROTEIN YBBM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="329"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1965001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="562" mass="61942" checksum="5AA2070C3F7E198F" modified="2024-05-29" version="1">MGYETEVLIEVSYWTLLLATLPLLGLVWASWYLNLGIENGMLVGIIRALIQLSVLGIILEPIFVRGKEMWGLVLVYVMFMITLASYEATARSRYYFQDMFWYVLAMLVANVTVVSLFAFGLLLNLDPLWDPQYVIPMMGMLLGNCINGVSLSMNSLLSGVVESSREIELLLSFGATTNEASKRNVKDAIRTGSLPGLNGMAIIGLISIPGMMTGQILGGTSVTQAARYQILITYLIAMSSFGTIFSQIFLAIRMCFDSKQMLRTDWLMKRSGKKSFFAAIFDLIQSCFVGSVKKDATAKGSLDEVSTLAPIGSLAIKTPVEKQQNQCIIEVSGLSFAFDKSKNSSETVQRRILFQDQHFRLREGERALVDGPSGVGKSTLFRIIAGLVPSWEGDVSLCGIKQSSHQDMSVWRKQVLYVPQTKVDVPGSPNALLETISQFKVWKTGGIADSPSLDEMTTSVKSLIENWGLDETLLNSEWKELSGGESQRMLLAISLASRPKVILLDESTSALDMATKVKVEKSIETYCEREGMVAIWITHDQGQQKRLAVSLQEGSGISTTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8S0</accession>
    <name>A0AAD2G8S0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002279">
        <property type="protein sequence ID" value="CAJ1966337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8S0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="448" mass="50227" checksum="2DEB5C488C323D10" modified="2024-05-29" version="1">MAKTKYTKTSNSHDDAPLSPSRNKQNHSSADRKATMGATKPTKTVIRVSKRRRKPKRYHIEDDAPSKTDALPHSPRQSSHQAKSAIVTPAKHKPKTTAEIAKNKTAKTTLPFVDDMAREMVTTDDECEPEEAPQDDRKPSATPKLKKDAKLNNPKRNIDDSSDTDTSDDDDGFLSFDIREPAAALAITKSKRARHNHNAGLSLAEDLVHAKEIGGDKQPFLRKHLRKIEMLHPNRVVTACVGDVPGTVVLICLLPKDTNRSPPIQVTLDKILNNESALKQFQRHCKVHMIPNMCDETNPMIPKACGRTGDYFQGKPWPLLLCIRQKRWTSQELTEWAETIARALTAVSDDQCRYLLPLAYAGDITPKIKQPLSYYITVPDVLEALKLYYFPNTDINTILAREDIGVYLDPRSLKLARDAAKRGQGNGVSYTYNEALDPNNPAYSYFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB36</accession>
    <name>A0AAD2GB36_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="222" mass="23918" checksum="A97BA24BFE0C5F9F" modified="2024-05-29" version="1">MIEEGAYDEASSTLCAAFQAYQNCDCAGGMESAVCDAGVSSFKPSISLDECMAKGHPMSSSVDPDFPFMYSDAIRISPEVAAAGISQHDVTSIILFNLALTHHLSALDSNDPDSDLQKALHVYEHLYTMQQENMVVGSSGFPSNLMFVLSILNNCGIIHQWRSEAGTSINGEVIAARCFDKLLSVLTLISDNAQTTNKNEEVVVRGFYRNVVLNRPPAASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBT3</accession>
    <name>A0AAD2GBT3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002402">
        <property type="protein sequence ID" value="CAJ1968726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBT3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="210" mass="24232" checksum="0C16DFE8D8D66F6E" modified="2024-05-29" version="1">METLDRRRMLQESFWGSLMPVSTYCGLLSISSPLPSHAYTPDPDPLKESLYLICRVQEATCLQERYINKKLPPIKKMKLTLRLVDRSYRLLDQINYISKFMDPTSVVEAVQAGNEAADSLQEAIDFVYTYKDNDGAAMTLEQKDILIASLTNTREKLFDFVAYLPDQGKLQEARKRVEEENRLNIDEYDPDLANDAGIYNPIELPWKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBX0</accession>
    <name>A0AAD2GBX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS23675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="508"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1969378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="828" mass="92769" checksum="432E7EF69DB8FD6C" modified="2024-05-29" version="1">MNNQSRDSWDTSGSQNQDNPHQARPPANRRAGRGPAFHQPHGAAAIGPSSSTISQGTSVSQQHHTISNESPLPPTIQRFLGDRSNDKRKNAALELEAMVKVLQESNNHQMIQIVIAVLSKDFCTSMNSNYRKGGLVGLAATAIGLMQNSKNYLPVLLPPVLHCFDDPESRVRYYACESLYNIAKVSRQAILGYFNQIFEGLTKLFADVDVDVKNGANLLDRLIKDIVTEAESFHVAQFLPLLQNYIRRTNPYIRQLIIGWITLLDSVPDINMLDHLPEFLDGLFNMLSDSNREIRQAADSALSDFLREITLSSVMEFGPIISILVFQCQNKERLNRLTAITWLTELINHPHSGGDALLPYQSDILGAIMCCISDGEMEIRVVAERTNEDLLTLVKATHEDFELKTLLETLTNELLNKEDVPTKMAALAWINMLMEKRKADMIDYVEELMPVLLRTLSDPSDPVVLLNLRVLSRISLAQRNELGGAEKTEEAQFQLVLNAILNLFLKDRQLLETRGSLIIRKLCVLLNAKSVYIRLADALMQFETTVDGQVTNAETLEFVSTMVQTLSLILLTASELHDLRSELAKSIVKTNVRPVKRLQTKNGSITGVSQVFSTLFRCWCHNPVSTFSLCLLAEAYHVSFALVKRFSQVDDVSVGFLMQIDKLVHLLESPIFVHLRLKLLDVESKSHAPLLKSIYGILLCLPQGDAFRLLNNRLTAVCNLRDNLGLSKLPTKDEAFPKTEEQVTVDKLLQRYDQVREMHKVATERQRSLAFQAEQEQALGKNSPTLRTLEAQFPEQVTGNSSVNPIATISSRTSTDAGITNKMGRFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCW9</accession>
    <name>A0AAD2GCW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002343">
        <property type="protein sequence ID" value="CAJ1967726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCW9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="174"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="689" mass="78459" checksum="74650F9E5E674870" modified="2024-05-29" version="1">MFKAIVDYKKDPKVAVSEEKSYVMSKNGQRRTRKTTKGWKLMVLWNDGTQSWIDLSVLKESNPVDVAEFAKAHHIDEEPAFRWWVPYTLRKRDMIISAVKARVRKTTHKYGIEIPTSVEHAKRLDAQNGNNLWMKALSKEMSNIGVAVEVLAYGVLAPPGYSKVTGHLVWDVKMDFTRKARWVLDGHKTPDPLYSQYAGVVSRESVRIAFTYAALNNLDVFAADIRNAYLQAPSSRKDYIICGPEFGLENVGKVALIHRALYGGKTAGRDFRNHLRACMHHLDFLSCPADPDVWMRPAMKDDGSEYWEYVLLYTDDALCVSMNPERVLRKELGKYFELKEESIGPPKIYLGSNVRKVELDTGVQCWAFGSSQYVQAAVKNVESYLNDRCKAGDERFKLKPKAMTPMQTSYRPELDVSPELEPSDASYYQSLIGVLRWIVELGRVDICLECSLMSSQLAMPRVGHLHQVLSIFSYLKSHHNAELVLDPTFPVIDAAGFERKDWSTSEFGHIENLKEELPPNQPEPKGIGFVTTAKVDADHASDTTTRRSRTGFFVWVNGALVYWMAKKQTAVESSSFGSEFCAMKLCCEYLRGLRYKLRMMGIPVLGPSFIYGDNKSVLANTSIPDSQLKKKSQSIAYHFIREGAAKDEWRTSYVNTHENDADLLTKQLPYGQKRRKFVNRLIHHVYEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCZ4</accession>
    <name>A0AAD2GCZ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002447">
        <property type="protein sequence ID" value="CAJ1970012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="498"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="594" mass="68056" checksum="E26C67D469BB2188" modified="2024-05-29" version="1">MELSEPTMQSQQMLSFLGSNDTMFDEPDFSFTNSNSYSNCGRSHHSRININNNNNKRNQNDEFQHQQQQDTRRKEMKSTEALLSSAINELSMQERSKAMDDLHCVGDEIRETPEMIQKSLAEFDQGVHDGNFPIYNQAASQNRAYVEQPSFRLMFLRANSFDAKKSIQQMLNHVRQKAIYFGVEKIARDISIEDLSSEDIEVLLSGLLHVQGDKDRAGRSILCSFGHLMGHWNNPTCGWTIENVIRAHYYLMFNVLLPMPAVQTKGIVAIYYESVSKDARFIMPTPNDFVTMKAYRNTIPIRYSALHLCLKNEKQGLPLQNSFLETMLKSLPRYTKVRTRLHYGNDTENLKSLRTYGIPPDSFPVDEEGKIRSDILNVWFIKHYSKEGNNNRGEEEANNNMDDQSFELFSRDDHDFLMEETMQFGFADDMGTDERPIAFPLIEVPAPADSGTGTYSNDNNNNEQVVNRSAPAPPVDNNSNNNDNGNSNREPVQPAETDILLGRGVRLMQHPGNIRFREFLERYQDDYDRAQRNKRRKVSSEVVRALTGKGVRFLERNEDGDWVVADHAEAEDKVGQLFRSRRKLLNKKGSIGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDM4</accession>
    <name>A0AAD2GDM4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS24390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002502">
        <property type="protein sequence ID" value="CAJ1970371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041897086" description="WSC domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="129"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="237"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="346"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="10">
        <location>
            <begin position="458"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="753"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="754"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="793"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1970371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1073" mass="116729" checksum="58DD6EB7326BE35C" modified="2024-05-29" version="1">MTASLLILTSLLLFQTANAVDPPKPQYMGCFGDAEERAMPANGYSSDAAMTIQICVDICAHASYAFAGIEVGTECFCDNDYTRWGELDQSKCSAGCAGDYNEECGGSWAVSVYATDSSVEQQPLPLPSFATPTACVADDSNNRAMTQVELSPVYTELCIDECFKLGYDFAGLQNGNECHCGDDTYNKNGYLNAAVSCNKECIGECGGVGALTVYDTTHSDYQFPSAAPSTYHATWAEERKLACVLDTWDRAMAVGPKNMHTVNSPVGMTVQACITYCEGLNFAYAGLENRNECYCGNEYRTHGFAPVTDCYHKCNGDQSQECGGPWRVTVYATGSGPFTPLPGQPSIPNLGCWADNANDRAMTAHVGGSELRGPVYVQRCINYCFTEGHKFAGLQAGRECYCADTETEYQKHGTSTGCDRECGGIAYGNCGGRDALTVYSVDEHNVDTRFARPATGNCIATAWGDPHIITFDGLKYDVHVMSEMIFLKSRSTDFVLQARLEPVYTLSWNSKPAVTTGIVIKGATAKLPTVQVSLVPQGQTGEKPSTVRQQCDVELFVDGTAYGFYENLETNDAHVLLSGSMIHISYPSQKLQLDIKVVVWQNVCHFSIDYVLLDCANNNDYVGLLGSPDGDKTNDWMDENNAPQTIPSGAGGYLFQPAYDYAINNWCIGTPIDSYFTYPYENLSFSSYTNCLEPFDPTFEDALIAAENDPNNAKCNGDLGCILDTVALGDEAGDAYLNEPAILETITAEIIESPPAPTPAPVPLPTPYPTSAPTSGPTSGPTSGPTKAPTPSGDGGSGGDDSGSGGDGGRSESNGAGSNGDPHFRTWKEEHFEFHGQCDIVMTKVKNFANRIGIDLDIHLRTKIVRYWSYIETVAVRIGNDILEVKGSAAQEDDDDKLHYWSNFEYHGELADLAGFPVTISPRRNKYTIDLESAYPGQKIEISTFKEFVSVKIIGATEDSFGKSIGMTGEFKTGRTLARDGYTELNCFNELGQEWQVLPSDGKLFHEMSRPQFPEHCFLPEDPHGERTRRLAESTIAEEAAEAACAKLKDELDRKDCIYDILATQDMDMVGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDS3</accession>
    <name>A0AAD2GDS3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS24493</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002524">
        <property type="protein sequence ID" value="CAJ1970477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDS3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010487">
        <property type="term" value="F:thermospermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="13">
        <location>
            <begin position="255"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1970477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="746" mass="83084" checksum="98DDE484887F8BE8" modified="2024-05-29" version="1">MTDEKNPKPLTVDIRVFMLITVSAMAIAFGVGVAMGPTAAELAMASAASSAASSAAGGSKLPKVHSVDVRSVEEAKALKGDAAELLHEPAGQHLLVDIKGIEAAFLDSEERLAHAMVETVKGAGLTMLSYHCHKLIPMGVSCVGVLLESHISFHTWPTEGVITLDLFTCGPNPLIPVVPSIKALFGVPRENDEIVTQWSHELRGFRSKNKIPNKDNHNYALLDHDSDLSQMIWSPMDCVYKEQVYSGLTEYQRVDVWDVVSLEDQPSQNDVLKAKLEPTDARWTTTELVQPTRYLFLDGVLQSDNTTHKEYHEALVHPAMFAHSSPKNVAIVGGAEGATLREVLKHKTVESVTMVEIDQQLMDLAKEYLPQMSDCSNLEGRSDNCFDDELLNLQIQDAKDWFLNSQNENKNNNLDVVIIDAIEPEMSAAISKDLYDKPKLWKSILDSLTEEGILAIQIGYAPTISDPKPDVGYNAPREILFQTLESLPQVEAMFVYEDSHVGFLVPKSFLIVCKSNSCRQRFYAAPEDLNMEIAKRIVASKDNTGSLQSYDGVTQIYYQVAPKAWETIYCRREPTPFECDYRHLDFGKGIYEFKMDAPADEQVFEIVADDQGTRVYSKVNIPKGSYIMAEHAANSLQLSSKAVDNLSASTDVEFAKFVQDHGHDSASKGSARRLVEIGASYFLRIADSKAESNVGRWIPPHPQGRRPKYSPVYERHRLSFDVFMVATKDIAMGDELVKYKHMWSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGR2</accession>
    <name>A0AAD2JGR2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001727">
        <property type="protein sequence ID" value="CAJ1947460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="205" mass="23496" checksum="2F861C0F01110E87" modified="2024-05-29" version="1">MFETSENDDFNVHIEIGDSTDGKFLDEIKAKYPHVDIFLDDGGHTMEQQMFTIKHMLPHVQSQGVYMCEDLATSWLKKFGGLPNEHVSNSPEFLKHTMVGLVHQTMDWLLASSVSGKSIITRPDLDQVADDVFDSSWWKVIPSQVKHIHYYNQIVVYEKGVTYKPSPYRTIGKQIPYKESGTYDSLDWTIIMEKLDSIFGESLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHJ3</accession>
    <name>A0AAD2JHJ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHJ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="120" mass="13793" checksum="1B95736086384193" modified="2024-05-29" version="1">MNSLRRLDVESFSGFEYPDAEICRNAFLKALWLNTSLERTCCLHSEYEVDEDYEVFEDIISFGSKLAVPLSLNQGGRGALQNQSINCFPRGLWVLVYKRAMTPKYYDVSDECGYPTRTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHW7</accession>
    <name>A0AAD2JHW7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHW7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="234" mass="26965" checksum="3AC479C42656018E" modified="2024-05-29" version="1">MPNKISFIVACPVERCHDPVVVGKGRKLCSLKGNDLHSFASLRHKRLSSGLDRNGGAEQLLPRAPEILLQKLKPKQVGVKKKKARVSRKERYAVPSDDEEPMGTDTEMESSPTLLAQPSKAGWLDLVLLPRFHTYCQKMRMHYKTFHMGHKLPSGCEAESLTRMRTNVDMWNTSHPDRQIKISVFQQNYKDVCSEQLLDEMKYFVLDDMQKDNLWQRIIEDYDEKAKKEVVDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI38</accession>
    <name>A0AAD2JI38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1952877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="138" mass="15884" checksum="0D349EC4DD92AD06" modified="2024-05-29" version="1">MDFMVIAAPAIAAMQERSDILGGRPEDRKARVHSLHPLQEKLMQNLFSVDCKLGIETKQEIPHPYPLQQKLMRKIFSATATETGSEIPQVVITDPRPLRQQPEPRVKISLRRRITESATYTWQLEMTEESPFVFEEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIA0</accession>
    <name>A0AAD2JIA0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">palmitoyl-CoA hydrolase</fullName>
            <ecNumber evidence="7">3.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS14248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:84099"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74410"/>
            <dbReference type="ChEBI" id="CHEBI:233601"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098599">
        <property type="term" value="F:palmitoyl hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF27">
        <property type="entry name" value="LYSOSOMAL THIOESTERASE PPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042063673" description="palmitoyl-CoA hydrolase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1953645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="386" mass="43412" checksum="283B992BBA89E9AB" modified="2024-05-29" version="1">MMRKSFSSTLLILLISFPTVITTSRNEEPRLCHSPELYDDFPMLCQMLDRLREDGDALADEITAWAAEHQLLVGEGWDMTNAKQLETTLSSSATSKLPVVFAHGMGDSCFNSGFQNLVKHTSTLLNDVYSVCIPTGKDKSEDTTNGYLLNMDASVDVFAEGIKADTMLKDGFHAIGLSQGNNVIRGYITRYNEPSVNTFISINGVNAGTGALPNCFPSVDNENGGKKVGSVCSLLTEQASKRAYSDFYQQHNFQANYWRDPNHQDEYRKFSQLARWNNEGEPFNQSYKDNFLKTKKFVWVRATKDGMVWPSEGEHWGAADPAAPLKHILPRNETEWYITDSFGLKTAEEAGKNHYISFEGDHLQFSMEDYTDWVNKYLGDSESVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIK2</accession>
    <name>A0AAD2JIK2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS14574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIK2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1953976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="202" mass="22530" checksum="117FE9C28C4CE6E9" modified="2024-05-29" version="1">MTAVDAEQAMTIVGTIGGFAISLSLVPQVYLTYKTKCADDISYTYQFIYIFGTALVNAYAIYFKLYAVYVPCLVEFSLIVTLTVMKAIYPARQDLIDCSRHSIKMSSASKGSATPTNLQIIQQLIADEELAAVGHQGHHFDSKEFEKNMIRKSITLMKQMAVKGHHDIEHHDIEAPTERAQLSELDDSTEKAENSADQKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJM4</accession>
    <name>A0AAD2JJM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="17749" checksum="0047FDA778ECE297" modified="2024-05-29" version="1">MCRPIQEQAFQSQPNLIRKLGGESEMGFLLMNFCDSINEDADLQMVFGHMSMTRLSAVMSDLIKSALESNFVVDGDARLRVIMKNYAVFELGINTKQFKKLKTHFETALQGSWVEEDILEECTQRFAALRIVFEEEGKDFERTAMATRVLAAQLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKF2</accession>
    <name>A0AAD2JKF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carbohydrate sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS17812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1959390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="36218" checksum="2C371B1BBE0401CA" modified="2024-05-29" version="1">MDRSQKSYYLLLLLTVGNVVFMLYNLSSTFSSEYAETSIEGMSKMKKKHMIRPHDMKKMFIYNTHSWDAAPIVVEEYKLIFFAVGKVSCTVFKQLLRRMMDLDDWREDSGPLPHNPNKNGLKYLYHYPPGKALEMLTSTNKGWSRAIFVRDPLERLLSAYLDKGKRKNGSYMAKHCNKEHQVDFSFEEFVGIVSSSCKHDPHWAPQIQRIDAPFWQHINFVGKFDTLQSDTKKLLNRVGAWEDFGESGWGPNSNETIFSKATHARHETGASGHLEEYYNSSWVRKTALQFYGKDYACPWFKFRKQIVEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKR7</accession>
    <name>A0AAD2JKR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002010">
        <property type="protein sequence ID" value="CAJ1959614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKR7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="56928" checksum="5EA749F6EEF9F9CF" modified="2024-05-29" version="1">MTHEKQEGLFKCWTDERVGIALLAEVNLQWSAVPRGHKWFDWVKSFTNQGHFSSVSYYEHQEFPTPSAHQWGGCSATLLHKVARRAKSGGKDESGLGRFSWIKIRGRDIRQQESQTDGPPAGPLDLVVVSAYRPNKEGTNAGSVWNYQRNYWLSKGVTMDPRDKLTLDLVDLIKQWKAEGCEIFLGLDANEDVSYNSPSSFRQAMRSEGLTEAILRQHQGPYPATTQSRTTDTPIDGIFVTDGVCVTAGGYLDFQQYFKSDHRGLWIDIDLEATLGAPPVTSPSFQPRRLTLADGRSVDRYIKAAEAGYRHFRLPQRLTQLAEDISVQDGYLTANQQDRFNTIHRQAYEIRRHAECNCRKLSMGKVHWSPQMQQKWDRLHLYQLLILGYKQVRTSSRKVRRLLKKTGLSDAWKLSEADLQAKWYVEHQAYKEVKRKRAHQWRLEYLESQSAAVQKAKKGNIKARSRRTRVQRMAQKEETRRRRRAQGKGFSGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM19</accession>
    <name>A0AAD2JM19_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002141">
        <property type="protein sequence ID" value="CAJ1963372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="283" mass="31213" checksum="92A1BAFD6D59E81D" modified="2024-05-29" version="1">METPNQQLAKLNMIRYEGGTMTYDSVATLFGRIATILNRFNHENPPPTNLSDLAGVAFQAFTQEIKDIVAEHLETGAAGPLLMDYPSNLSQMHHLRKRAEKDEKRIKQIVGIANSAGRIRPNRSYVPGRSAPPRPGGRAFAGFHQQEFQGFQGFQDDCSFQAPEIKTGGTFHTAIMPPPTRAAKQNVRVTDGQGRQLVVPTSDSKLYCPEAAVNMPLCMSIMEELGQQQGEENGRTMLSQSGRSTAKGKRQAIPKPLLGMQRGRTQFPRLPTQRGPPSPKTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM33</accession>
    <name>A0AAD2JM33_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002141">
        <property type="protein sequence ID" value="CAJ1963370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="194" mass="22222" checksum="3550FB20654AE072" modified="2024-05-29" version="1">MEQAHQLNISVNDMLAFLNFPIGLNESNTANLKGLYDTRGCCNMGKKDYHLAIAKQHPHLVKQIFDLQKIRYAPIKIGGIKDSVEIDVIIEYFIPFENKQGENHTLMIGLTDDLPINTLYGLPFILKAKLVAQFYRNAVISNFFNQEFDLTLECPRLLPTEHVERNRSSDRKVFSGCTMPHFLAYNLLQPEHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM59</accession>
    <name>A0AAD2JM59_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM59"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="24322" checksum="AFD11470DDCF5579" modified="2024-05-29" version="1">MLDSQSPTQLASNDPSVQPSSYPSNLPTSSPTSGPTPLPTSSPTRAGPTSTPTSGIIPFTFPPQTTYSKKGGNAIEDSCFYSSGCHSQSCPSLDPALITDFTYYTNSRAVPIEGFDIDTNPVWYLEQTLDGSDCGSNSGSTACFDDPLKGGFAVDLTWSNFVFHKDTRFYSEGFTTRYRVAVDGTVALQETLSNRHNRTLGSDGGKVMTVNAGGFCGSVNGYIRLTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN69</accession>
    <name>A0AAD2JN69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN69"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041985208" description="Selenoprotein O" evidence="3">
        <location>
            <begin position="26"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="899"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="949" mass="105552" checksum="138978E5D2897EAD" modified="2024-05-29" version="1">MGMRESYFWCLVVLIICIGFTSVQAGEVSARSLQESTNCQSQQSIQYYSIPPFAVQFTTLDVNEIPAVSNVVISETDAKASSLTYPLKVLTEEFIVSKFRERINSMNLSSSSSSQQMYHDYYRQLTEVELRVILKHNPKVTDIAGHVALIATLHGTLHFSHSSGCGGTTLVPSQDDITITFGAWLESILETNRNEYLQRLLASNQEMLKEIVDFQLVPNYFQDGTGGESWLMAVWVVLAILGLCGLGAALVWMMRGKPPMKSFVGGSPYDPNHHSPAYTDDDVDSLRLSSQLDSKQHGMNESAHRRHSLDILNKSEEYLTKHRPDWTEGGGHPQGNFTKPFGNIMSLFDLSTSDGSNHSVTNTPEKTPRGRRSFATRQRSSIELQAGNIAAANSEDPSPFDDVNLNQSNHEAYSPGGRSHEEEIMMAAAAQSSAYRPISSIWRSVTSAFQGSSSYNENDGIMTNANFFYDGNEDEYFAKLEEDRLQEEQWLTFLKEEEQNYNFAFKDFPRKDGTPCLMYDGSNENEADAIFNAPLPKESTTGEEEESDIFNAREVLSDEAFRQLLHMNVSPSFEETLESPSPALPVTYKSPEFNERLSSLFAEKHRQYEKRSIVERHQQKRKKEREMERRERQKDMHRELEALEAGMAMSDKWRAKHHVSPRPYDLSPARPSYSPNIHVRKSPARRSPVPPSGGRRSPVPPPGARRSPVPPMFPMTHSIPPRHVASKSIDTLDSDSSLQLIRPRMSRPPSAAPPSELFLTDSHRYHEPLTTDLDPSSLDKLSMPAMSKNPKHPSPSSVLDDLSQIPPTSGSLIPPRNPAAIHRRNNSIENPQYTTPGTGQRKTIASMTPPRRAASPRFGTRGMSPIRHSTGTRGVSPARSVTRGVSPARSVNSTTRGMSPARHGAASPSSRGRRPARGPSPKPGPRSASNSSRHSRDGGVFDHGIAALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNZ0</accession>
    <name>A0AAD2JNZ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002361">
        <property type="protein sequence ID" value="CAJ1968092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="447" mass="50963" checksum="E895CB25EDCBE04F" modified="2024-05-29" version="1" fragment="single">TCEDIYPPPKEIAEALQDAGVPSKSAKGEMKYNYPKLNKLAKKLFKGITTHFQDTGLGQNLARDSAPLLKAIIFCRRQISVTEAHPLFQPYGKDRMVFIIDNCEKTCGLQRPVMHFRTLTEQKKSKTKGFRSGDDGLRLGLCMLLPEYRSAVGLVLSGKKDRKMMDQSCDPSLALFEKIYDEAFMKRDRSFESLSEDYWKEMAELPQDKDRWNPNNPSIFEHKRGGAWLKETWERYLRPRYKAALGKWNKETGGGQGKPANFYRYCGKQCDEWLVWVFIKDMEKNFLLASPTGGQMPAHISVEAGFESESEDDDVRSTSSSSSVSSSGKRRANYNKKMAKRKKANRKETAVKLAAADQQYSKISRMIDVAENLMKSMQSNMVANKTDTVASFVAEVDVCFEKLNNTAHLESMSPDSKESYKRFWNSRRKSYMARVKEADQNGLFGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVV3</accession>
    <name>A0AAD2PVV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS16795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="26"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1957608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="410" mass="46585" checksum="9D6AA6C00B475FDA" modified="2024-05-29" version="1">METLSDNQEIVMSICMVVSGLLSMFGSTTIVYRVLRKDGGTKPFDRLMLGLSVFDVIASFSFVLTPFVLPRETSVRVWAFGNKVSCSVLGWLSQLSVGAAWYSCLISFFFLATLRLRISNVDFEVRFEPYMHGLTVFYFLFSATFGVVFDIYGENDLQLGCWVKEVPKGCDEDGGCLTITTSFFMGGLPLFFTLFALPINYVLTFSHVRKVLKFVARHNPIQAAHIRRLAEQGTLYVLAYFISYGPQLVIRILAAFLDYGRADEPSIYWLLALNSICYPLQGFLNMFVYSRPNFLRLRAAGMPFWEAVRAACFETDITQFLDRTGNLLQIRPSVHYDSSEEMEKYHSRVESRKSQTDLRVTHLLSQEFKAALGKTRMPEMVEFLSSENDEDIGSVEYQTEVVDSSEEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX77</accession>
    <name>A0AAD2PX77_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002201">
        <property type="protein sequence ID" value="CAJ1964728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="111" mass="12161" checksum="4C0CA5FF37817FC9" modified="2024-05-29" version="1">MWLAAAEFFAHPWTGPAIIPPVVEEFERLERESKIAKAQSKSKKRPESTPENPKGAKAHDSRPSPSVPMQTELTPPKGRSNPYQQTPPSDATPPRQQVVMSDAVHVIAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXF9</accession>
    <name>A0AAD2PXF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="351" mass="39177" checksum="AC1EC70BEA5B175C" modified="2024-05-29" version="1">MTSMAKPSLANMPSDRKRKAPIIMVGSQSRTTNKLSRSDKLAKLLAVEEMAAFRRRRRRSFQVSEVLDQAGMKLWRQRVVQWFFDVVDHFELPRDVVYVASVILDCYTTDYTIDSVISSSHYREVSIASIFLAAKTLKPSRMPMESLLQTVGKTSGKMTLPQAMEAVRRVVSALDWTYPILVPSVFVKQLFGMAAPFFPAGQSMSLPLEHMLYLTELAVLGDLSSSRSFASDIALAALLQTLNPKTGPADCCLTQESFQLSTEKLGSELNLDCSNNETIQFLCQEMAGIHAQSLGSISSHQEPKSTPSKPTPVLIEEDSEQETSFEETIFEEKNQVESSMCRSPAKRIRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBM2</accession>
    <name>A0AAD2CBM2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1896022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="590"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="1006"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="890"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1272"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1399"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1277"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1399"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1421"/>
            <end position="1430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1896022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1430" mass="158391" checksum="9DB173FA148B6928" modified="2024-05-29" version="1">MSSFNNWDDGNSFASEHNVPVAEETSWQDRRDSLSDGSVDPAMFSNMFNEEPLGEPGGNNSAANRPNNHGNPSILEHEEEPASAMKGTGGSVLSNNNTMAVENGHQMGSTFHETSETDTMGHMSNGLGPMQNGNHYTANGVIVTPHEMNGGGQHTGMDHTSSQYIMKQAPQSAQNGTAESNMAIHHENATTHSVDPSRYNQTTYSGFPQSQIAVPATPAAAHETHNSVDQSRYNQSAYTGFLQSQAAAPDALAAAHESMNSVDPSRYNQNAYSGFPQSQAATPAAAHETVKNEQEASHIQRDLEAVASMYNMDGQGHPSNSSTNNGGGEAVIELLDDDDYTQEMNSAEDHNNKRRKLTNGDASVDAATAAAAARRASMPDWMSNRSSQQPMQRKAVPIQRPTAMAPRPAAVPSWSMPPVEEQRQTSVIHEPSYIELPDGFVPKWDQLFPIQRRPQKTERRLFELSLLNVQEFTITGLPLVEGMEPTPVTGFRSKIKEICKPHGKSTFEKDKEGVGGKWRIPLGAYRTFYSWLNSDVMTKVIGIPESQLKIASLGKARLERGFPSVGKILSKGVPKGLATTLAPFQRGGVDFVAERNGRALIADEMGLGKTIQSIASLSMYWEEWPLLILTPSSARYHWENEFRHWLGADSPVNNDMGNSNGLDFGGEDESAEQQNDFDPRLPQARPMPLLHNSQINVLTSSKDPLFPNSDTRVVICSYGLAPTLVEKQMIVPGLFRCAIVDESHMLKNIKSQRTLRLVPILHATNRCILLSGTPAFARPSELLPQLKILSTEKATWWGDERLFVQKYVKRTSPARRAELFALLTGTIMIRRLKTDMLKSMPKKLREKVLTNVVSPEQRKEFHQCMMMLREGKGVLGQLARQHSALDTVDDHDSHAVSLSNEKSNPSQVSDHARAALAQQYQEQFQQRTQQLVHSLDTVRHQLDPTQQQEFIQQQQYKIRRELDAWYKEQLQQQEATIEEAEDSRKTVLNRMYTLTATAKIPFITEMIKRWLADPTKGKLCVFAHHKFVLNDLINLTGLSNESGSTTRYIRIDGSTSPKLRQAQINAFQTDPDVKIAILGITAAGVAVTLTASSTVWFTELFWTPALMIQAEDRCHRIGQNARVKCLYFVAKGTLDELLWKLLERKFRDLGEFVEGQEKMKIVVDKTYHGEKEFRSIFSKPEDDDIPDDAMDFGDIDGEDTGESLFDLDEDIEGDITMLGNEEITRTFVPGGDDDGQDPESKMASGTGAQSKPAKKPILGSSEDDAIALLSDDEDEQPSTTANGNTQSAAFKTEKVVSSANGSEPAKPTRNRCYNQIFDGPKFEMLLALYNGRPIVSQRNTRTPSRPAIADILVAVNGTTLPVLLDMNQITQALKKLIAKGPVELTFMDSAGWTSHLLQPQAPQRSPQHRVANSMQNQGSDEIIELSDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCY8</accession>
    <name>A0AAD2CCY8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6816 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1920236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCY8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049213">
        <property type="entry name" value="DUF6816"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20670">
        <property type="entry name" value="DUF6816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6816" evidence="2">
        <location>
            <begin position="69"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1920236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="267" mass="29126" checksum="C524B09D48D1818C" modified="2024-05-29" version="1">MTSQDPSLENNNDMEWRSITQRRKFLQSSSAAILATTTAASTFLPSPSHAAAPQDAGEAIRRSAAKIPGYGPTDVFFSDAVQGSWKATRQVEFPGRSEPLTLQYPFRFVQSIENNAVVADRGINQAELEKALVEAVSKSNGGNAVRPSYDWTMTNPNDLRLILADGSKKEIKVTKRATENTENTVTSSEFQRITLEESSDEKGFSVPSVSARRVLTKWKILLDENNSTTIEALEVVYNVPTGGDPMAAGSSNAQPSVLSKSRILLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE31</accession>
    <name>A0AAD2CE31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed primase/polymerase protein</fullName>
            <ecNumber evidence="3">2.7.7.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS1096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22509"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.102"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.102" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044917">
        <property type="entry name" value="PRIMPOL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399">
        <property type="entry name" value="DNA-DIRECTED PRIMASE / POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399:SF0">
        <property type="entry name" value="DNA-DIRECTED PRIMASE_POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03121">
        <property type="entry name" value="Herpes_UL52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1924658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="657" mass="75115" checksum="471DBE95F26A1238" modified="2024-05-29" version="1">MTKLSNTANSKIKVEESWRTEEKENDTPKKLSHGIAPKGFHRKRDKEDSSVVKVKLEKLKGDIETSVLSQGMQQHALSLETKRKAFRKKTTLKSWPLQDLAMDHLDHLLGKNSSQQFHGGDHLLSDSSSSMESMEHNKRRLSPNDKAKTATPIVKQETNDEEETTTTCTTDDITTNMNEPLWSREPRIFATEKSQGKRKYIVGHFGRVADWYWRKANSKHLYEVIREQTPCRLYFDLEFSKTYNTDIDSDQLLLEFRQELAAELMTHFEISLDAQQIIDLDSSTDAKFSKHWIVDTPNCLFVDAPTVGRFVKRLVSRLADEMATGHLAQRQPELAKHLFVKTKEENKTSCFIDLGVYTRNRLFRCFASSKFGKKATLEVSRSNKYPLQLPPKQPPKKNASLQDYIAANDWEPHARVLAKTLVVPLSLRGETDKPSKIRILRVEEQAEMFRQYKGAGRPRWNERHNRPVPIRTSASPVPSLDEYVNTELSSRGGVQGSIRVWSMEFGPRDVPVSITYQLNKNRYCELIGRSHKSNNVFWTIDLASWTCIQGCHDPECFGRGTPTPIPADRLKPMQEELQQWEEERFEEALLALNLEETDDNTTKEDEEDATAASTDVITSESSSNLKADDQVDKEEVDNLLSDDAILDAVLSNPELFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH54</accession>
    <name>A0AAD2CH54_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000350">
        <property type="protein sequence ID" value="CAJ1934645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH54"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="235" mass="26198" checksum="D2CC5033B10A18F6" modified="2024-05-29" version="1">MNANFGPILKTHSEADYDPTGLLLRCLACMVWHAKSFQEYIAHNPSNELVKVPFYNMRGSEIDALQQLITVEPTPDVMTTVTGVPPHIETTCQMKAIHDNLIQLLAQTRISEDNQKQRDEQLKADLVAAVHHGIEQNAISNGNITAKGINDIIQKHQDATNKQLTEHFKVMLRSLPPQLQGCQPAPIPPPGNQVQQGGGLLLQKPDQGKYIYTDRFWSVPEGFEFPPKPNLPQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI00</accession>
    <name>A0AAD2CI00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000280">
        <property type="protein sequence ID" value="CAJ1933535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019144">
        <property type="entry name" value="Membralin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF4">
        <property type="entry name" value="MEMBRALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09746">
        <property type="entry name" value="Membralin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="388" mass="45112" checksum="5874CD80B9D5AE43" modified="2024-05-29" version="1">MHKNFVFRLNQSNCASSCLSSYTQEADVIYLGVDSRLNHTMSIVERDANCKDIHSMSCTGEREVGDFNIEYSYSSRKGYLLLDDDDPITESLSVQYIIVSPHDLQCFGDGTLQFLAWELGMGWNTILMNWLLVFNKPDEIAYVRHTKTERLQELRIPSVKASGFQSFVKTAISKLSVLIQTFFLFFFCTTLVSFTLNETQERMLQFTQELSRLVARNLPINFLVTTHVLDSFIFCPLMVGKFFFLIEFYKGDRFLAFLFMSVVWFVEVFTVMSLRSYHGITYFPRIFFLLFCLFHIYYFANPSIGFSYLAFAVIVLFIIHSMMFFWHRYELPAVAFGYINMQRPRANAAFHQGPHDLPRPPRVRRVFQVSFDAMISSDTSLFRTAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIR0</accession>
    <name>A0AAD2CIR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS3712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32472">
        <property type="entry name" value="DNA REPAIR PROTEIN RADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32472:SF10">
        <property type="entry name" value="DNA REPAIR PROTEIN RADA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13541">
        <property type="entry name" value="ChlI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Zn_ribbon_LapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01874">
        <property type="entry name" value="DNAREPAIRADA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041931205" description="RecA family profile 1 domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 1" evidence="5">
        <location>
            <begin position="200"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1934350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="669" mass="72641" checksum="C5593A76D9558A9C" modified="2024-05-29" version="1">MLKPRLSSCTIVCLLITLIFLPFHDCFSPIKSIRLIRQQQQQHGLTSLSAQYSDDFEHEEDDDDDDDDDDDDDYIPEVDVKNFKPPKTAASFGFNSGRSSPSIRKAMGVSGKSAAKVFVCTNCGTESVQWRGKCPTCHEWNTFQEFSANRGNSPNNKLKPRFGSSASSGGRSSTWLDGIDDSGYDRPVSVDKIDRNAESSKRLLIPDDDELNTVLGGGLVKGSLILLGGDPGVGKSTLALQLAAQIAATSTPPVGVGMGEVPTSIQGPVWYVSGEETMEQIASRAERLHVSTLSQLLLLSETSVERIANQVVSLLDIPDGQVAENYPPSLIVIDSIQTMMSEDIMGSPGGVSQVRECMALLLRLAKSTKIPIICIGHVTKSGDVAGPRMVEHMVDAVLYLQSSGDEGSFRWLRASKNRFGTCQVVGLYEFQDGRLLPNPDMKESPLREEDAEGAALAITVEGGSRAMLQEVQALVTPSSNAFGKKIVDGFPYARVNLLLGVLQKHCHVIIGNRKDVYVNVAGTSVKNSNSAVELDLAVAIALTSSHGSVPIRGDTVFLAQVGLLGELRGLKGEMEARLIQARRTGISRAIVAGRKFKITRKFDLEVIECPTLKQALELGLTSGSIPRPRKMKRTTKLKSDSNEPNSLEDLDLDDVILDDEEDVEDDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ16</accession>
    <name>A0AAD2CJ16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000546">
        <property type="protein sequence ID" value="CAJ1936077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042026268" description="SAP domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27931" checksum="FE23571834AA6C2D" modified="2024-05-29" version="1">MKATLFSLCAYQLLAPGIAFFPTSSAISKSSPALVLMENSNIVDMEKEVMASARLKMDKKRVVSALDKDKASKEDPQKTALLASTWQISAAAGISAFIGCECVTHSNFLSVLVLTAAVFSAWRDPVDDEGLLGAISRLLGRATIQTVESSKPRLQRIARAAIMDDGDEDYFKTTAGRQTLADPRLAQYIEDLEKDNTSLSLWKERRELVDQYLSYYSLDDLQSKARERGIDTNCRKAQLMMKLVEADIIQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ64</accession>
    <name>A0AAD2CJ64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS3914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000336">
        <property type="protein sequence ID" value="CAJ1934572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1934572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="180" mass="20607" checksum="2A0E300C23B5A212" modified="2024-05-29" version="1">MLETVEKEGNTSIISWLPGHPQDAFKVHKKEEFMEHVLPRFFDQTKFKSFLRQLNVWGFERINDSGPRHGGYRHSLFIKNRPDLCAGMKRTKIKGAKQGDSAMGSQQQLSETELQQNINAILYHSADGDHQCGGQKRGGTKRNDETSFDTIEYERIPDNIPVAAELSRMYAEEMKETDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ78</accession>
    <name>A0AAD2CJ78_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000347">
        <property type="protein sequence ID" value="CAJ1934602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042235748" evidence="1">
        <location>
            <begin position="22"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="260" mass="28885" checksum="1D44DA8E63CE3330" modified="2024-05-29" version="1">MISKITAPLFLALLCAADAHSARVGDKNAPIYGEECFLYILENSDWHHETLPQILCGGYQNEMIIYLLDEEHEDNPCQMALDSVGFESAISTINEFHFEECIAMADADLKAALNEKIVPGESPRHGRAHSVHTRAQEDVGTSFFSEACTSSVLDDIGYNWHHEDLPLKLCSGYHNEMMYFLAKPSEETGGSPCQDALDGAEIDPAIDFITMFRFEDCIAEVDKEMDAMVADSYGLVGSHHGEGRRAWYCVFPLMCNSDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJF7</accession>
    <name>A0AAD2CJF7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000517">
        <property type="protein sequence ID" value="CAJ1935863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJF7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="80" mass="8810" checksum="561DB99A7610A00E" modified="2024-05-29" version="1" fragment="single">SSAGDILAYFCFPYAGFAVVLRHGDCLIFDPTEPHCISSKAVSRDIYCTSFYCKSALIGGNDNSKKLTAEQMAFVEQEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKD0</accession>
    <name>A0AAD2CKD0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000635">
        <property type="protein sequence ID" value="CAJ1937357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="176" mass="19918" checksum="C3A2BDE9D9FD8D10" modified="2024-05-29" version="1">MEIENATFLTCIDTTVRYRSCIPVQNLKTDPVFEALDKIFRRYNKAGFQVKIIKCDRAFIPLTDDMLDDMGVTIDPTAAGDHEPTAERNNRTLKERVRVALARLPYKVVPKVITECLGRRAAELLNVFPQKDSISSHFSPQQLIDNVNINYKSDMVAELGQYIHAIGTDSNNSMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKI8</accession>
    <name>A0AAD2CKI8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000358">
        <property type="protein sequence ID" value="CAJ1934676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="836" mass="91967" checksum="739601FC5C841EF8" modified="2024-05-29" version="1">MDAKNNDEADIQQKNDDEYNGKNRQEQSDDSSSQQSEKDQARSSSPKPQHKPKTILAAVDMTGSVISPISSKPGSKREGDESLLKARYRYSNFQEDEEGGSSYSMDLLSSRQSLGDNNTSAELMVQQIYDQRSKLSAGSKQAGALSPPPVTHQVSSLGTKSPRLQSSNSPIAPGAYSVELPNSARSRNDDNDHLGNDGHGSSVMQLEAVPVDETLEQAKLQQMEEQMNREIERRLSLERKMTQEQTHHSKSCVKERMPIAMALVIILSAISVGLYFLLASTSDDVAADAGSSSNFIYPPPTTEECEAVRNGATVPNQDNYPSVMMESTVDVSFYAEFADSVNTVLMEVQRIFEYVALPALIGCNGGVDQEYFNQTFSPNRYIIANLDVLNVTRSTSSDCTADEPIRPCVRVVFRYFLWTKTELPVLELVSFMQSNFGPALIQSSSHDSEIIHQTTLVSISISPSANDPIPKNDTIDEEPNDDLLYPPPTVEECQAMINGVEVPNQDQYSTMTVDAAMDVTTYDDLEDSIDTLLLEMLAKMGSSVLPTLMGCSDTGEEALKVTKYTETRYILANADIVQVKQSDSNCNPTEPQPCARVEVRFLLWLKGEVELFDLIPLVHNDFRLILVESLTQSDIIEQVVLASIGPGQDDSPPNLDNGINVDFKFPSPTEERCEAVSNGIAIENQDSYFSMLADVKIDVSTHAPWEDSLDLVLLEIGNQFQTIAIPTLAGCQDTEEKLLNSTVTADRYMMVNSVVLNVTKSSDDCNGKEPRPCVRAIIHLQIWTMEEVRIFDVISAVDQNYGPSVVAKLGTGNKTNHTDSIIKQVEMVSLSSSVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLS6</accession>
    <name>A0AAD2CLS6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protochlorophyllide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLS6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042206443" description="Protochlorophyllide reductase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40214" checksum="F4A07834B12065FF" modified="2024-05-29" version="1">MHLSLLGLFVAYISNCYQPTAALSLQGPPKSDRKGFLHQGALILGGSVPLGGLLSVPEAAIAAPKLYEPPANSQVGKVHIITGASTGLGLESAKRIAAAGATVVLTSRTPTKGEAAVQQVQDYLSQKNVANSNIYFLTLDLDDLSTVQSFPERFSQLLPNTKVDVLMNNAGIEINKREITRDGFERTFQSNHLGPFVLTALLFPLLNRDGSRVVNLSSTAHSFAGVLDLQDLNFEKNYVGWLAYCRTKLENILFTQELQRRADAAGFNWFTTTCLHPGVVGTDIWRDNVAKGSDITSKLFYGSMKTVAEGANSQIYQATEKPTLLKKGRYYDEFCNVKQLESFAMDPASARALWEESEKLSGVAFKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CML3</accession>
    <name>A0AAD2CML3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CML3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050994">
        <property type="entry name" value="At_inactive_RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF58">
        <property type="entry name" value="RECEPTOR PROTEIN KINASE-LIKE PROTEIN ZAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1936259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="43781" checksum="B14E18839851896A" modified="2024-05-29" version="1">MVEENDETKPADTGEPAPAGDVDQDSDTGSDGGYDDSGDKSNEPAHEESFPEEPGVSSKSIPKERFEDEEKQEEENGLNSSPNKKAAKEEQKMNPKFKDLQETGRWGEIGKKEIMVGAVFVVLAVIGVIVALVVTSGDDTPATIEARVIRPTGNPTSSPTNPPVAATVLIDIVVQALENSSSVSAIADPSSLPRNSAFYDGLADQETASAPQRAMSWLLATPYNQYDKDVMDDFVIRFALASIYYQLGGASWTRSDNWLSSESICNWEGVDCEIGGSEISDLILDRMNLNGTIPREIALLQGIKKIWLSNNNLKGEIPGDAFGELSNLAVLYLNGNQLTGMVPSSLNPNQNLNTLYVQGNNLSGRWPFCPTIFGGAKVIQSFGLDCLEDGVGVFCQIGCCDDFACY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMR5</accession>
    <name>A0AAD2CMR5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="121" mass="13896" checksum="F3FA78325C0FE787" modified="2024-05-29" version="1">MDISTTYKPNYTDVDTPRGRNMEHVSFDFPELDDDTCSPLPRRKDENANDFILMSSLLMMLGGVATHAAKVTGHSAEYLLRMLVTTLKEKWKRTETHPVIGQELFFECQKPIHASQEVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMY1</accession>
    <name>A0AAD2CMY1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="507" mass="55311" checksum="CF4B7A29DB1C8FB2" modified="2024-05-29" version="1">MPYDDDSYEDDDSYEAADDAYEDDDSYEADDQPPPPVPHGNDIDADSYEDDGDSYEDDPHEASLSDHHPPRPVPGDNDSYDDDSYEAEETNVPIPPPQHDDDSYEHDDDDDSYEHESPVPQKPPSARRGGDDDSYEQADDDSYLPDNIRQNPAPFSPEPSTSRRSGDDEYEEDDSRFSIPPPVAEYASDSDEEKTEQSVPFDDEYEEGGDSQSEVGDIAGATGNIGSNRTEVAPQKNVVREPDSSDEEDVYAEESQDDDGDTQSSWGNHGTAQSSAKQMPISDDDSDSDDSEPNPTGFVDSDESDDSSDDDETGALKGYNFDNDDFFDEDNDDDSDNDDSDGESEPFQKRHDTRQSNPGKDKMSIFGREVSVAEREKSLFAKERKMNRYVALAIACICIAGIVGVIVYFVTPSDDEPAAVAPSPTLGPSPSPSLAVQNTVESLYSIALSTNEVPAASLIQSMDLLAEQVFNASNVNVGTIRNRKLAIVGVSRPSSLEAASTSKDCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN42</accession>
    <name>A0AAD2CN42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="535" mass="59224" checksum="AD65E8E5E7452A40" modified="2024-05-29" version="1">MTDSSLSTYTCMGTQMVVITSKEDSSSSHPREGLMVVYQKISEGDNTSSDQEPYPVVRIRLGTDQGTYQCDIPQSKVSLSKEKKKRLPEILMQDQASSSNSQSDPIQLSFQFSSEGELKIFLKQKLTSGMSKNAFRDVLQKETNVSLLRFCSDLGEAINGGMSKVTKLQEDLQSTRSNLQQWKETANKLETGGTQEKNMLLKGAYKAWIQNQAKQKKRVEDLTKQLKKGGTSPTNRSPIPGTLAPDDVEQAIETNTMSQSMVEALAEGRGVYNDNERKPILNKKTMNTTWKNDKEDYDKERRAKRRGKTKRSTSSIDEEMEEAPKPSRGQTKKGTKRGRKSSESSESRMLDDLPKPKATRKKASATRMDVDSGDDNDDDSFKKPAAQPTKKRSEPTNYDSSETDADDDDFKPAQKKTRVTPPATSTKAESDDDSDSEDSLLAHMGITSPIKKSKKKASDSDTDDDTSVPGATAKEDSDTDDGILKPEAKAKEESGSDSDTDDGQDKNSNSALVKSLLKTAKKVKENGKDDDWDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNK6</accession>
    <name>A0AAD2CNK6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000735">
        <property type="protein sequence ID" value="CAJ1938562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="404" mass="45875" checksum="40F707B29F709F8A" modified="2024-05-29" version="1">MKRNDKVQIISDQLPPSLRYRLASLIGKEAATFLWNANKQFRLDEPVLHKLRAIMHSLETETWEIYIPQMIPRDPHFTSYGDASFLGGGAYSDKLLFWFRIVWSPDIVAGTKLKASNPNYVHINSLEFLVAFLQDVATVVRLEGTSHAHPGLAHKFPNGFSQFPVLLTEKWMNDARTNSPFACLLVNLHGQLLKRSPLTALSDHTPGDNNFAADFISCPNKNIGDQTTFDGIPIAFCVNDVTCFDKFKRKVSISDFLQNPDLVWRIKTRFSHQKNGNHGEEKLFIRSEKSPLRCYIRRMQSILSRFDRLIGITKTNVPLAVYQDGACVLFLHDAEITRVMRHVACSLYNLDPKKDKIQYSSHSIQVGACVLLHTSGATTDQIKFLLRWKSHAFMACCPSVHVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNU4</accession>
    <name>A0AAD2CNU4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000768">
        <property type="protein sequence ID" value="CAJ1938774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="176" mass="20186" checksum="06D447308CFEE306" modified="2024-05-29" version="1">MPATIKAHRASRVIIKKDNKKVTKILVGRQAAVKSHMFVTEMAKILAAKQQNVPIKVNVVVKNSKHAKRMAAFHRKQEEDAQQTMPMANNIAFVGPTKAEVNEWFHDKKEKQEEAEYIYQAFKAWHKFSPDESPPLNAFMCQYLMGVSCDANVVRATFRNLKFQVTIEPHLIRKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP11</accession>
    <name>A0AAD2CP11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000158">
        <property type="protein sequence ID" value="CAJ1931528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP11"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041113">
        <property type="entry name" value="Heliorhodopsin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038020">
        <property type="entry name" value="HeR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18761">
        <property type="entry name" value="Heliorhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1931528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="341" mass="37952" checksum="D05CAA8F8A29080E" modified="2024-05-29" version="1">MSSNVREISPDRNQHHDDSTIGTDAHTLGTMKTISKPVANNTNDSAVHYLEPGQLNEIPKALNVFHLVGALLQTAEAIFLFAYSNNVNLKWLLYTNYPVAVDNALASAIGGEGTDNVYFARPDSRYLTSFSVPWVTGAIIGLSAIDHIFAIIPGGRARYEHDLARSKASYRWLEYSVSCSLMNMHISQLVGVTDVHMVILIFVLSISIQYPAYIHEVVNAKARADGFAQYWSPFVFGCIPWIAVWGVIFSYYSESIAAGEDPPSFVLPTVVAVFVLESLFPILFVLQWLKIGIFEDYIIGEYGYMILGLIAKSSLAWITLIGAEKYAESFQYEETTTDFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPX4</accession>
    <name>A0AAD2CPX4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS7755</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="168"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="436"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1942054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="546" mass="59603" checksum="BB7DD6779C001266" modified="2024-05-29" version="1">MTSSDNSVEEKMEFSDDKSPNTSENGTDSSRPNKRARLDASETEAIDKSAAPSTSKEEGNITLADPALLEHAKTRLSKWAARLFDPDRPRGLVQGPITIPLNDEFLTAFGKREKEYDEKTGNVLNLDSTIASDDENDDIDEEAQKQKQAAQEKKEKEKAAKEKRKSRTKVKISNLAYRTSSEALTTACQQFGPLVEVKLILDGDKEPTPNMQNSGRGYITFETAEDAEACMEGLQSLDGRPVRLNLANVKPQGGAGKSGASSSSGPPRPASALNRSLEKDISTICYRCSGVGHIEGDCPNPAKPKPCPLCGSTEHIMYQCPYKQICFNCGTPGHVSRACTYQRGLPRRICCSICLYPGHHQSQCRAGEKYIHRDPNMMDIMKGATSLKWFHGLQGITCNNCGAQGHFGWECPRPKVHHLVQDNELAANEIARATADSMAEQLEQERSRNRGRDHNRGGNNRRREVQSLPPTRGGGGGGGRRNSSGNGRGYDTGSGGGNNNNNNNNNNNNNNNNKKRKNNNGGGGGNRRNSRGYDTNGGSRKRSRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPY9</accession>
    <name>A0AAD2CPY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS7997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPY9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="39"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1942538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="630" mass="70533" checksum="D9D4B4DC989BE378" modified="2024-05-29" version="1">MAEDHVEQAIQQAESVEVDNDGLVDIAPSFHPTKNDGYALIDNVSTTSGKKKLLNEMNLLFPEGSVSAILGPSGAGKSTLLNVLTNSLSSNSKAVADIHLPGHSSFVPQDDQLHGFFTVKSYMNHYAKLARVNMPRNELDAKIDELLKQLGLTEQKGTRVGDIFLKGLSGGQKRRLSVALEALTDPMNLFLDEPTSGLDAESALQLMEFLKNYARGASGRRVILTIHQPSTFIWQLIDNVILLAKGKLMYEGSRENMEAFFAKYEHPTPREWNPADHYVTMVNDEFRDHARSVDEWAQSYQDWQKNHHLGGPESSSFFAPPKRSGKERTTSMVAAANKGTVDTKRSNSFMAVGPLLYRYFLNLWFNPGILGTRIAMYSMLALMVGGLFWELGDRTDYESIISRTAVLFYCVAFFIFMSVAVLPFTVMERGIVDKEVLNGYYHPIAYQVAQGLSTIPAAGVLAGLTSVIIVFMLKLNDGWWYFLNMFLALCTAEALAQMVSHVVPHFVIGMAGIAGLFGFFMLFMGFMVLPSDFPYGLGWTYDVAFHTYSWRSFMVTEFQNLTFDDPRSPFATGHDVLKFYEIEDVNRWNDMIVLACYAIAIHLISFVVLTIRYTFFKGTIYSLNGKKHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQA1</accession>
    <name>A0AAD2CQA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQA1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000006">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="380"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1942444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="764" mass="87481" checksum="CDF10B8348CA641E" modified="2024-05-29" version="1">MSEKKRFNIKPFRAHVPMDRTVASQTWEALANAIDEIYNRNASQLSFEELYRNAYNLVLHKHGTLLYEGVSDKLSSHLLATVERVAEVPDSSLLEEISKTWKEHQITMIMVRDILMYMDRTYIKQQRRRPIYELGLHLFRITVWDHPRIQPRVTELLLSTIASERAGLLTDDRSLLKNNLGMLLELGQADSSNVYERDFESLFLGTTQEFYRVESMDYLSKTTATDYVTRAAKRLEEEKERSGALALPISTESPLQRIIQTELIERHAKTIVDMENSGFASLLKDDTKLEEMKNVYNLFLRVPSSVDFLRDALSERIKADGKSLISDQEKGAADAPAFVKGVLSMRSRYEKIVDVSFRGEKKTRKRMKEAFEDFLNTDARAASCLALYVDEKLRIGLKGATEEAVNEEIQNIITVFRYLSDKDVFESFYKQHLAKRLLSGKTVGDDAERAMVSQLKAECGYQFTSKLEGMFNDMRISSDMRDAYKQHKRHQETQAAAAEPTSNKPLDIEVDVLTNGYWPSQKVPPCTLPTQVQDAIKKFSDFYLEKHSGRKLSWQTSAGSADLKATFGSEPNYRRHELIVSTYQMCILLLFNEKETLTLGEIRSETQIPDQELRRHLISLCTPKNRILRKGSKGRGITSDQDTFTFNSEYTSKSKRVRIPLVKESSVKKGDNAGGGGAGGGAVANRVPLVVEEDRRHLVEASLVRIMKARKTLHHNDLIAEVTKQLSVRFTPAPQFIKKRIESLIEREYLERTKRDYRVYQYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQS4</accession>
    <name>A0AAD2CQS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl-CoA:ACP transacylase (MAT) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FabD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQS4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052760">
        <property type="entry name" value="Mitochondrial_malonyltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47170">
        <property type="entry name" value="MALONYL-COA ACP TRANSACYLASE, ACP-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47170:SF2">
        <property type="entry name" value="MALONYL-COA:ACP TRANSACYLASE (MAT) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042002726" description="Malonyl-CoA:ACP transacylase (MAT) domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="3">
        <location>
            <begin position="52"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="351" mass="37194" checksum="95116868A3913C48" modified="2024-05-29" version="1">MARLLLSSIMLLSVSRFSSAFAPATRRFSRNAMSLAASDSDFDDFSSKVAFMFPGQGAQFVGMCSEVCKDVPEAKALFDEASEILGYDLLEVCTEGPKEKLDSTVISQPAIFVASMAAVEKLKSEKGQEALDEATCAMGLSLGEYSALCFSGAISFADGVKITKARGEAMQAASDAVDTGMVSIIGLDSDTVKEVCKAASEKSGEKIQIANYLCKGNYAVSGASKACDVVAEIAKPDFKARMTVKLAVAGAFHTDFMAPAVAALEEVLADVEIKKPSIPVISNVDAKPHSDPDTIKKLLATQVTSPVLWENTMDLILGKDFEKACELGPGKVTSGILKRFSKKAECTNVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT97</accession>
    <name>A0AAD2CT97_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS8219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT97"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="121"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1942984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="175" mass="18597" checksum="B202E66BA4C00F42" modified="2024-05-29" version="1">MSVVGNNRVGIPIVVLHDAEGAVIEVETKKGELIRGMLFEAEDQMNLYIKNAVIRDPNGVKRKINQVYVRGPEIVFIVLPDMLKHAPMFNRIKHWRKHGGAPPEGVGQAVGQAAAILRKANERRRGGFGGRFGGRGRGGFGGRGGGGGRGGGPPPPMGRGPPMGRGPPPGQYGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTP0</accession>
    <name>A0AAD2CTP0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1943505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="558" mass="62122" checksum="001A753FEAAEFD0A" modified="2024-05-29" version="1">MAEFITEAEDIVVSSTKVETKSERLNTEAETEVEDCRADDAVGREHEDGREQVVDIQEEGEDVEEDDEEDDDEDDEEDLIEKNAIAAVTEMLSTAILESIGDEQLHDAEKPPQDPVLSVKATTLLYDISGKMNDPTKNLADLLAAINPPEDGEFNRAYMIRRKNACGAMHLLTAEKGKQRIQICWTKGVLDSLKSVMEDCMELGIEGFLPNDQTRDEYKDARRRAVATLMNLSAAQENRLVLLHFPNLISSLLSTISSAPECSKGGAATLAHLSKTKENRLFLAKIPGLFDTVADILVPGADDHVIEGADDEMTVISQMYDERGGADLKGARQNMFALLFHLGKEKDNTYHMARNGRLIDALAAVNSYLMSDFQEYASKVLANLSRHHGNTRHICFRHPNVIQSLVTSSYSFNEDTRKLSCQALQNFAHDQPCRLELSNMRIVIPSLCDRVRDGTDEEERLSALQSIKSLSEEPSNLIVMSNTPNCMPTLIMISDGTDETASEMMRYVASDALANFSSHCRLLATAGHKADLENKGEEDPKVDLFVPTFNVTTWEQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUK1</accession>
    <name>A0AAD2CUK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001657">
        <property type="protein sequence ID" value="CAJ1946205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44516" checksum="4B4E0864890F8FA2" modified="2024-05-29" version="1">MEKEIASPIAMNCFTFHLSDYTNSQFAPLRMILKPSKMDDAKEDCVRLLAHHGGLTILHGDVCNAFITAKCLEEIHSTACPEFGECESAVVTINKALYGLRSSSRVYRETFAPFMFTIGFEPTRYDRDVWMRLGEGKSGYNYLCTHVNNFKNVSKDPQRWVNAIVGAFQLKCSGAPDYHLGPASHPETDASDFLHNAGKCQYQMLVGMVQWAITIRHMDIAYGRFPSKQLPVCSDPLEIHPTLLDKKGDFIPNFLKEYPDAKEDRDPKEPKASRKSVQTSVFFDANLAHNLQTCHSITGLLVYVGIEEDMSLRYMLRSLGFPVEEPTNLIEDNLGVIQTASIPEADLKKKHVVISYHCVREAVAAQIVKPIWCDTSKNCAETLGGVKLNAILSRTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUV1</accession>
    <name>A0AAD2CUV1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DOT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001391">
        <property type="protein sequence ID" value="CAJ1945383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUV1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031151">
        <property type="term" value="F:histone H3K79 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOT1" evidence="2">
        <location>
            <begin position="276"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="410" mass="45538" checksum="F4F77FDAE4DB6F0A" modified="2024-05-29" version="1">MPTAVETSPPAIGNEPAIGNELGAENEFDNEWEAENAIETQMPTAVETSPPAIGNEPAIGNELGAENEFDNEWEAKNAIETQMPTAVETSPPAIDNELGAETASSTSPATGNERRAETALLEFPTAQRSIKMEMLERFDLSSKRFLMETLHPSNEPVDLDSVLLDWKNTDEAKVHECFSQRFLPLNTDDLEKLLKNKIWVPPGMALVSDSMDFINKTEREKAKKQNQLAATLQKRKTAKTVARSLLRKSTNPYHPILKFIHAEFGRQGTKMAHNGSSTYAEVTYESISGLVEVLRDQNVSSASDCIIDAGSGISTMVTRMSVELQCQALGLEYCHQRTYLAANATTKLYDEFRDNKDLNQGTMLVLGDLYDLKQIPKQVTVLIMFDEAFPPDLMYHMGDLIKTASSNLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV95</accession>
    <name>A0AAD2CV95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS9324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV95"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="98"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="196"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1945180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31362" checksum="7BF91F4335A064F3" modified="2024-05-29" version="1">MGAGAKEYPKQYFAASALASALGYPLWRAAAIGQSGFQMNSIHVGGVAVPRSVTPYVYGFLPPYKGMVATVFGMTWARASIFWMSDYGHEVLLNQGYSKSVATVAPPLAVSALVQVLNQPIVRSTVTLQDPKYNLPNVFSSIRQIYATHGVTGLWHGTTAGILKTVPKYVTAIAVKDIMEETLPQPDPSSPTYESDRFYRTVIKSASAGVAGAALTNPLDVIRNEQFKTGTGIRSTVQQLWSEMGPKFMVRGLGKNMIAVAMPVGMTIFFTDLFVQQSIDEEHKRSLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CW50</accession>
    <name>A0AAD2CW50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor Tu, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS10156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CW50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04094">
        <property type="entry name" value="eSelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01889">
        <property type="entry name" value="SelB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03696">
        <property type="entry name" value="SelB_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000052">
        <property type="entry name" value="Selenocysteine-specific elongation factor EF-Sec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049394">
        <property type="entry name" value="eEFSec_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049393">
        <property type="entry name" value="eEFSec_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF11">
        <property type="entry name" value="SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21131">
        <property type="entry name" value="eEFSec_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21208">
        <property type="entry name" value="euk_SelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="17"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1946014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="716" mass="78127" checksum="E839DCD70402C1B3" modified="2024-05-29" version="1">MSKNDNGSSSPPPAEEVLNVNVGVLGHVDSGKTSLVKTLSTLLSTASLDKSKQSRQRGMTLDLGFSCFFLDMPDHLQKLYPEKKKLQMTLVDCPGHASLIRTIIGGAQIIDMVLLVVDAFKGWQAQTTECLVLAELTSPHLVVALNKIDMFPENERAERLEEAKKKVQERLKRSKFPNAAMIGVSACIGGEKVAAGDDVASNPTYNINTLVQTLKDSLPAPKRIVGKGAPFYFSIDHCFPIKGMGTVLTGTVLSGSVSVNDNVEFPTLGLERKVKSMQMFKRKTLKISQGDRAGMCVSSLDSNLLERGVAASPGAVQLLKGAIALVRKIPYYQHSIGDKSKVHISVGHTTVMATVNFWGAKELYEQQQQQQEQKEGEKIDGHTALGGDADRAGLPYLKYDWDQDFIHQDGMLETLSSPSSSATTTTSKQQEPLLHWAMIDFQTPVYCPLHSLVIGSRLDLNDQNSNKSKDPMNGSEPSASSCRLAFCGRLMEKVDPTKDFTRIRSYAPKERVGVISKLGDPHTRQDDGKIVRYEVFGSDLFKKETVLKPFIGMKLTTPQGDIGELKSAFGTAGKFRVYFPGGTEAREGDALVMPFLRFAHDPEKKMRQNIVLPAARPGSRMETKKKTKVKPEAIGHVEKIKGDVLENGKQTVAIIVGFFTPEINVREKIGRKVLIPSTKEEGSISGSFGKAGKCKVTFENGISAAAEGAKAELIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYC8</accession>
    <name>A0AAD2CYC8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001079">
        <property type="protein sequence ID" value="CAJ1941804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYC8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="923" mass="105138" checksum="303EF3D2173E77B1" modified="2024-05-29" version="1">MRIEAEMIPLEMNASKEVKPQLSWYLATPLRALERQVEAAFLSGNFMHSDHFSRLLDKIVVAVGADKDELATSMLLRILNRIMGNCSDYVTTLAMYENAAECYGNMEKTFLKEGSPIQRFLQLLLDNKLFAITVNSIDKNEGNIVESQCIVINLFADHRQSATDETMLPEIDVKLEHCEASFFSKADFKVVTSSQDFQNFQNFENESEQDIYASSTCTWNEKDDNNNGDEEQSISTVSTFHDSEITDECQGKEYVLDDATSIIDDDDEDGNSSDEYDGTTEEEEDMEEEPSLGMGCIGLKLDDEWENGSNGLRLQLVYDGDNKYYGFRIFLNNPDVDGDGQQDKVLVAGLFEKPIQRRDPNDELIDCGLKQVIGFVSCDKKNSWATMGMMDSASARSNCIFCTQPKSTYKTNFPDWMVQYAKEHGFENERLAAKVEAGWKDYPSRCGEHSNSIMFQKLEEDTNNGNNTYSEDELRDIRERHGCVINKPLLDIHPSKQTFGALHNGAGLENHFKNNIDGRLGKIDALKTNPETVTWLEKVADAQGRCKQIKATTKRRLTTLKQKIKKLQANIDSTRINVERAKDPRRRFASTTDDCVHYMQAQLASLLAEKEPVVRECGKNLRLHNGAVALLKAIEKYDGTKKPKGPAQWAFRKAIEIAGPKFNPQFGGMDLSHAHGLLMLEKWSEIMAMVCGAYKPGDGKHEMVAKAMEGSEEIATPLFKMNKLLKSQKKWNDEKINELKGYCYHVFFKWLDIFPKQGVFPKLHDMAWHIPQFVTHFKMYGILSEESMESRHIVHKKLARILRFMPNKKQQNEVFTNRLQVYQLPEFEKVKAELIAKTTKKKRGKYNVKPKDNVLPISLPELVMDGANIRINKSMSIKPGLLEVYNMVVCGIVPSSWEKIFRDRDDIDDTQKIKAGYSSQLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYY1</accession>
    <name>A0AAD2CYY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS8158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="6">
        <location>
            <begin position="73"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1942862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="564" mass="63918" checksum="8CA7149E5A6C82D7" modified="2024-05-29" version="1">MSTPELIVEKGSESDSVVMVDHTDINSVESEDANIPSEPHAMQVISIGTEEDQYAFTFHEKKLNAIMSKIPPGWKVSVVSVVGAFRTGKSFLLTWFLRYLSHISATTATGEAVTDDDGKPWYEQINSLGNDAFHWAGGADRHTTGIWMWSQPHFINRKLPNGEMESLAVLLVDSQGMFDNETTMSLTASIFGMSTLLSSYQIYNVEKRIQEDNLQQLALFSEYARLAVEADQVHQENVKPFQKIEFLVRDWQNFEDEDDYEQMEKEMVEYFEKVIADRDAKDLQETREQISSCFESASCYAFCHPGKNVTKKTYTGDVTQIDETFVKLLDRYCKRVFSFENLQPKSIQGRHVTAIELGSYIKAYAEMFASGASFPEASTMLEATSHANNINAVNMAIGQYKDTMNRIAGPKCSNYIRAEELKEDHRMLLAKSLQFFDNMATFGSKQSIQGARKTVVDQINDEFDVYQSLNVGRNPLAGLETYIIPLSVAFISFMFRFIADYTCSPYSHVCRKSSEFFSHVYAVVLCFMLIVGMTKAQQIKELVQRVKSVVQMMNEGPSKKKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZY0</accession>
    <name>A0AAD2CZY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001280">
        <property type="protein sequence ID" value="CAJ1944938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZY0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="133" mass="15157" checksum="08A3D0A271A73471" modified="2024-05-29" version="1">MKYKTHFQNHTNWTIALDRGYLDILDDDDIADDAFILDAKYEATTGAEVASKQVHLTKQQQHQLATALENTQELFDGNLGHYKHKKIHLQVEDGAVPIHSKAYSVPVKHQHAFLEELRHLESTNVLKQCGPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC41</accession>
    <name>A0AAD2FC41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair and recombination protein RAD54B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1902231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="284"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="591"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="820"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1902231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="92957" checksum="1FD02D0701AE579C" modified="2024-05-29" version="1">MSSTNETDTHSYTVLYYKRKSKVHKSKGVSKMDGILTICPFAKATVILKDGNNTVYSGAIPDVAKQVDSLQEDNILAVGNYEVEICDRIGAKPPASSLASTKPVGIGNRTGFLPRSSNKGLRRPLHPSSRPLLPAKAASNVVSQGNSLTQSFANGRRLVRPAQPKPKPAPPEDSDDDDSDNDMSPMMKENTHCFPLKRQLSSLKPVGSIGAVTKVRRKVQKLATTSTNATTTAAASNLFVDAIGNLDVPHSIKRVLKPHQITGVSFLWNCLTGSGKAAKTSPHVPDDYCLKGAILADEMGLGKTLMTIAVLCALHRQKRDRRFVVVCPSSLVTNWANEFDKWLGKASQPKRVVVKKGGKEATSQIKAWSNKASEVLIISYDLFRMNSDLFGQVNKPVACLVVDEGHRLKNTNGSLTLTALESLPCQARLCITATPIQNILSDFFTIANFVCPGVLGDLPTFRKDYERPISAANNKSASNKIKQAGLKASRGLEMVTKAFMLRRLQKDILKTMLPPRNEVLVFCRPSAVQGKLYEQITKGHQSQGMKATSDALTTLIQLRKLCSHPALLPKGNDMHSDRIDSIVDVSGKLQVLAALLQQIREHAPTDKVVIVSNFTSALSLIEKSILGPQNYLFVRLDGTTEVKKRQEAVDTFNMTTADRHFVFLLSSKAGGCGLNLIGANRLVMFDPDWNPASDIQAMARVYRQGQTKPCVIYRLFTTGTVEEVICQRQIQKGNLATQAVDGKSSQSSGSNKTSFSKAELQDCFTLKRKIHCDTKTKLGKRWPDYTSAKSIVDNGCNDKALIAVAEDQSNPVSFVHVVNEAESKTGDSGSSNVLDSDDSDDSADFTSEEEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FET8</accession>
    <name>A0AAD2FET8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BCNT-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000280">
        <property type="protein sequence ID" value="CAJ1933575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FET8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="2">
        <location>
            <begin position="121"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1933575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="207" mass="23426" checksum="C646263E8EC94B7B" modified="2024-05-29" version="1">MVQEEQASTDTSNAKRKATGNKVDDAFERLFGYSWGTTFALDDTNMTGMARNLVDIFGTTKTARILNVRGSIKRRRIEKQPIVNYKDIVLPETTKSVAMEDTVFAGQVVKAKASSASSKPKKKAGKIDNILDKLKGPNKMNTVEKTNNDWESFKESDKQLQEDLEKRAQGKDAFLVKQDFLNRVDTRTFELEKEERDRERAKRGTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEU8</accession>
    <name>A0AAD2FEU8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000291">
        <property type="protein sequence ID" value="CAJ1933648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEU8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="282" mass="31856" checksum="51AF8763D85592AB" modified="2024-05-29" version="1">MIQKQEDKFGALYEGTDSTSDLDNVSLQTSSSRSDGESPALPLKQPVTIGSTDSRDIRSLMDLHAEDDFHNRRLSDQHVSEIFLRETNSLYSNTKSSKISFFVEDLQALCDRDEAQETAPSKHSSSGILIKTCSFGGVEIREYPIIPGDSPAGFKGPPLTIDWAPISTVRFPNVDKYESVRSRHRRTIKELSIPASQRMTILTNQGYTQSEIQKSTKDATRARRQRRITMSTLKYQVIMEKIESIQRKTVNVLTFGQHNKDQKEYLKKYLPSHGVIPTPMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFF1</accession>
    <name>A0AAD2FFF1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS4153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000391">
        <property type="protein sequence ID" value="CAJ1934816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="527"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1076"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1236"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="450"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="702"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="789"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="973"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1076"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1236"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1934816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1272" mass="145645" checksum="A5041581787498CA" modified="2024-05-29" version="1">MHIKQITISNFRSFRQQPEIQPFSPTTNVVVGRNGSGKSNLFDAVQFVLLSPRFATLRSEERQALLHEGSGSAAVNAFVEVVFDNSDNRFSLENSDEVVLRRTVGSKKDEFFLQRKRATKQEVQSLLEGAGFSKSNPYFMVQQGKIQSLCLMSDSQRLQLLQQVAGTTLYEDKKRESQIKMDENTQSIEKINSILSDIDQRLNELKGEKEELVVYQTCDRTRKALEYTLYDKELRKARHTLDRLENERTDHLESTANLHEALKETHERIQNAEGELQIKTQSLRRNRRQLQDAEGDKIKIVTLKTKLDLRCQELQEQLMSGKESLQRTEHDLTVLQGQIKTAQDDLSEKEEASKNEQSELQKLLQAKDEVSRKADSLYAKKGRGKQYSTKAERDASLRKQIKEIQAMQQEKQEWLQQQQGSLGNLRRETKTNDERIEATKNELGSKRESMQSIRKTLEDKQKQLHSLMEVRKNTWRKAEELQERLKENRDHMQRAMSDVRKSMPRATSMGIKALQRIVEEERIIVGEQFFGMVMENLRLKDKKFQTCVEVAAQNALFHVIVDTDATAARLMEHLEKRKLGRVTFMPLNRLKVGQNTRYPQSSDVTPLLDMCVEFDDRVARAMEHIFDKKLLAKSAEVASEWSNKVHMDCITLDGDLCSRKGALTGGYLDKSKSRLRAFAAQRTAEREYAKIDEEFSKVDVDAKRAEQEVTNVSQEVSRLQNKQSQLSRLVQTLEGKLASEHSQLSQNKKQVLQIESQAIPPIEREIAAFGSDIARLEDEIGTELTSVLSDTDREQLAELKESLKTLQSKISSQSEKVEDLRSDRQKLESLLEDNLLRRREELRQVFRDDTGGVVSTSVNNLLQQKESELDLQQQNLSEASKDLNEIDAKLEKARGVEEGLKRELIAAKQELDKLKNRDMKHSQSLEEANEKSEKLMSKKSMHIAKRENYMRKIQELGSLPPPKELEQYRDDSINTLESKLEQVNKKLKKYSHVNKKAFDQYVNFNDQRESLLQRKEELDNGAEKVRELVESLDRKKDEAINRTFRGVSKHFADVFKELVPLGAGELIMRTTLDEVADDGDDSDEDTSLITDHKAKKNKPEDPDVSLYRGIGIKVRFSKVGENFIMSQLSGGQKALVALALIFAIQRCDPAPFYIFDELDQALDSTYRQAVANLISRQASNPETPTQFITSTFRPELVAISKNCYGISHQNKVSSIHPMQKNDALRFIANLMHEEEAVGEVSEVKRRDSRKRKSVSEEGSGANTEAKRAANSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFG6</accession>
    <name>A0AAD2FFG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1912528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042270061" evidence="2">
        <location>
            <begin position="21"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1912528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="656" mass="72709" checksum="5DF0928B43771667" modified="2024-05-29" version="1">MRIVLTASVLVSLLLQHTDALISQSPISRSSPGIARFAEVSGADIEQDVGTARVQTSGYSVQYRGKVNEIDYCIAPADVSLSRAYDLSNSKDNTIANENTLSLTQALNNASNRAVRRIILAQCWPSEEALNKSLRLAAAAEMQAEDERIASGTTSKCPVPRPILNLLMRRDTATPSSIPNPKGRTNEQYVTDQIKSFDERYGSLPGYRYAEAYLESILSLATTGQESPRVSEVLGSGVYDESYKRVLSVLKSVGVTFEELSGTDRSKISNDLKNQDICLSMLDKLGQTSPKPIKVEEPEPVEANSEQEEVVEEEAPAPKKKKKKIRFRFWMKQEDENDSKKEPEPTNPEEEKPSKESKKADTGVVLLSYEEPTMTRQLNSLSNIVQRALLFGGDQELLILSETLDTNKAPFIERWYPGTEGSSANFDEETRPGVQYLNALISLLRTAYDVGLVTDLEPAVALIPSYSNAYERIMANLVELGSGYIRPMTPTDSTLPKPRTPTEELGRFAVWESRFRGESDGSYPEDLEGSWEVKDEVGGELIGSSTVVFEPQGEVSVAPPLQGLRWRLDPGPTHLDTCTFQVLSEDGTVLQYRGFIDRGARLEARFSKRSIGIRGSVMFQMRDGDIAGTGADYWKDMLPINYRTGTTKFVMNKSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGM5</accession>
    <name>A0AAD2FGM5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS6351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1938954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="107" mass="11544" checksum="2BB71ECEBA4DB917" modified="2024-05-29" version="1">MGSASSSPEMKQFVESEVQQNDVVVFSKSYCPYCIKTKQLFAKPEFQGLKVKAIELDQVSDGGAIQSTLTSMTGQRTVPSVWVKGSFLGGNDDTHGAYSSGKLQAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH24</accession>
    <name>A0AAD2FH24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS2216</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000121">
        <property type="protein sequence ID" value="CAJ1931054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1931054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="631" mass="71024" checksum="FF984C1441C4F250" modified="2024-05-29" version="1">MMDLLGGYNSNSDTDADGPVEKKAKKSDPRFLRAAPAISVMTRRNHGNELIHLVDPSSQIIVEAPIQGPQVLDPQVQKALAGEMQENYHFDETVFKKQRTKFQRTGQAVGPSQQSVVRTTLGYTTKRLEQFEKTENDQKKRPKFESKDPLVDGSDDEAVYGVWGPPSQEERWHAENSLSDIQKGGLESLAPEQLAERAYVKERDRLLGVQEEAKEEQPAWERLVDRKMAHLLPPKMDGEGVEPKSTFHGIEESNYKGQSWVAPPSGMRSVIDGDALDIDHHRCYVPKKCVHRFIGNDKGIHRIRLFPKTGHLLLGGGLDGVCKVWSIAEKKLMRSYHGHAAAVRDVQFNNDGSKFVSASFDRVLRLWDTESGKVLNTFGNKKVPYVVKFYPHDDNFFVVGCSDNKIVTYDATTAEITQEYNHHLAPVNAIIFVEDNGVKMVSSSDDKKVLVWEWDIGVPVKYISDPTMHSMPCMVMHPSLQFFVTQSLDNTICVFQAGNRFSMQKKKKFSGHQVAGYACEMTLSPDGRFLACGDGKGKLFFWDWKRHKILQKYHAHDKGPAIASVWHPLEPSTMFTCGWDGSIEVTADYISNPILAGSRKPGIIFETPKIEGFLDIIPILSIAYAILRRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH68</accession>
    <name>A0AAD2FH68_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000137">
        <property type="protein sequence ID" value="CAJ1931314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH68"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="562" mass="62207" checksum="7A4D79C72C2534EE" modified="2024-05-29" version="1">MKSFYNPPGYNPKLVPLECVSYATYGNTQPSTISIPVPKPKPASAAQQMIHCQNHPAPYHSTGAYPIQQVVAPLITRVAHSDHPQTRRSCKGRLPEISMVELQPVKKRQAVHNWQPTGHIVIGPEELFCKVWFQKNTGGGKIRRDAKEKIGKMPSMGISKKVGATWGKQIQEGSDIGIPDHTCERRNCSDEAFPEVATNKAPQSTIFCRREYQNSDQIEVECGKAFHLTGVDADTARTLETAAPQCVLYFNMIRDEATRNGYWNRIKNGKYTQQIWSASGNRFELSPHGSWWWLAQNIGMCQDVVMINRSIIYVGPHTESIQQWHTDLRETGDIVVLVALTHHNGVGGTGFLTDARSCKEVVKAEQAGTPCVDFEDSNIYTATYQNIGDTAVFSWETFHRGMGNNHESEPRLLLALNYGMQMADGTFHKSLGERDCSLNKTALDMGDCKAALISIYSTNAKYLEGQENQNSNIHGTIPCGRGKGLSGVNDGVSFVVLPYKFLVDHMVQVGEWMGIETVAVQCSDVAKGATPSPLVENIPAIVFLTVDSFAKMKSDNEGKLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHH1</accession>
    <name>A0AAD2FHH1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17854</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6561</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000780">
        <property type="protein sequence ID" value="CAJ1939370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001995">
        <property type="protein sequence ID" value="CAJ1959431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="504" mass="55879" checksum="3113731A6C55628C" modified="2024-05-29" version="1">MSSEYSSTIHLTQEELQQDVQISVSDAQEWTAEIPFIGLCDYDDNESVDLFLFITNGPKFTQAQFNPDHWPPTNADSYNGTLRCARNRKYANKEKNKDEYDAQGVCFGPCHKSHHHDRKRNRVNGQTKPRATQTAKDTTGNCLCNCRLSLKFSRNEEFIYLACKGEKIHKYHPKAPGPLPLKANNLTDEQKQQLLAQQRAAVANPQSRKILLELKQGYISKSAYRTVMITAPDYIAAKAVAGANSSAAEFIGWLRAQAANPETNLSYMVLSYALTSKNCCVVRRYIQNPKGWRSNSNPPSNPETVMNNLTYRDELLLPIEIQEPLASSRKSTPTPPIANEVDNQTIRNSLAYTSGDGKESCDEDTGSSHMDCNAAQGKVGIADKLCAKPAPIVPKGLYSIANVSIANQTNDNFAQSVEVESTLKGVAPMVELVEQAETHLLASSDTIMSPTKVMLGGAWMTEAEKRHFFRFPEVLFIDATHKSNNKGRPLLLVCGMSTLLAQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIS5</accession>
    <name>A0AAD2FIS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000347">
        <property type="protein sequence ID" value="CAJ1934622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="144" mass="16627" checksum="20E6C69669062F5A" modified="2024-05-29" version="1">MDQRPTFTAEQIHEMVEDRKDKRTPMKKFEDELAGKDVMEFFIFFMYYDGFKSAAEREGDPTVPHYGFNLASGPPGSVNHQRCYNRLRPMVNFRTRGHRLGALAKEFLDNNIEPPEECRPIEEDPEPPSDMIDEATRLLAGTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIT2</accession>
    <name>A0AAD2FIT2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIT2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019309">
        <property type="entry name" value="WASHC3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10152">
        <property type="entry name" value="CCDC53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="638" mass="73478" checksum="4ABF11B4E1A01202" modified="2024-05-29" version="1">MRFRKKKTKVEDIGAMDETPEDETFFKEEAKRNLEELCNELIERTKRETELIRQHLGIDDRGCCLRHPNQFITDKVLPNRRFETIKICLICDSELKAGGKAQRKSMTNVISDLNTLIEDKTAWRNKTSVMYNGQIPEEEEENEEEENAGTTFKKWEPANPEVEHKDFSHMLKFYNPEVEEEQAKARKKSFRKKKKAGDDESEDISAIIEHEDVMWKEEVKQRVAHVRAWDGDMALKQNPVYAKYFRMVNVGIPMQGIQQAMEMDGLDIRIMSLDPNRPLQDQVDDIPDMSEEERETLRRGDQLALMRDDDIFEPLTIDETVEMIHRAYERRAYFMQELEDERNPEKRKLQKKLMKKLGKGRAPPPPLIEPKRRELPPKPEEEGKGEEEEEENKIERRPAPSPRARPASSPLTVDTTVPPKRSSRGVSWSNREQVTTTEDIDSSLRGEPRSQSRIHTPSSVSSTHATMGTPRAAATPSPKGGLLSADTADSQPPVLFPEPDDKLPGFYSDEELLRISKKRRPFKPVTKLGATKYAVARTKEELAQAEKELLQRTVITNSLKTQLERLQKALEEADMDVEDLQHELYQLDPADPLCTRPSKQEEKQDEDGPSSPFKNVDRSDVVKARMSKLSIMPRTLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIV0</accession>
    <name>A0AAD2FIV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040000364">
        <property type="protein sequence ID" value="CAJ1934697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1934697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="40653" checksum="5AFB9A29024832DB" modified="2024-05-29" version="1">MEENDIVSLDHLQHNEEKHKDDGLGTSWYNDGVQSKIDHAILLNDGQAEIINTYKDYLLNPDNPGGTALPPSVALLTCKGGTGKSFVTHQLLKIGNHKTKTVWTLASNNLNAADIDGSTIASVLKQRIQQKMEEAKTVQQKISHAAVLALERQNVCNARLIIIDKISNVTASKLGQLSRLFSECTQKPNEFFGGIPVLLVGHSNQKEPVGGLLATTSLLKKIDNETKAKEDATRRKQNKAKHWKMLSNHKSASIIDANSNNVASDSTLGCKILASCRWFELTAAERSKDKEHNENVDRLYDGMPIQLDKFHMYKMYNDNTLMADSPEERLRWLKAPVIVKTNRERCAINYARALQFAKATNAILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJM9</accession>
    <name>A0AAD2FJM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000502">
        <property type="protein sequence ID" value="CAJ1935745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJM9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="423"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="854"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="880"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1067" mass="118565" checksum="6F765DF02A004BD2" modified="2024-05-29" version="1">MSEAATVSKVDEKKDDKPSVDNATLAFMLRESADIVEKGEFDVILYHALQDFRTYYKLHLPKRKEKAKKKPAAAATAPADSGENSSDAAATSSSDAQKEANTKPAETTGEATPPTVSADPSTQELPAEQSKSDNSARETSAGATVISEEGTESRTTPSTSDPPASSSKLQVDGPESAAVEPGAPENPINTESGRMGSMDSVLDSGRSAEDFDNEASLRDAQAKQNHFAPFGKKAKNTGSKISAGMFASKTKMKLPKKLPKIHVNLPSSGKKKREAELADLTGGEVAQYAESSRRRAAVGGEDGNDAVMQSPQRSSKLAPAVTGLDDKEIRSTSATNPVDRVREDEPADAENEKPSSLRNNETHNATNNSASVHPTTATASAPSTASSSEVFVADPRSESFEYEMPDHGHGKPAFQRPKNKNSAVVANGWIEQQRRSKMRTVWKEVLASLVQGRRPGEETTLWIQREAVDPTTGKKELEALHQVPVKLLESVVYSEYTTDDRFSLKLYNSHEEFVFRCNNDPSAAMNWVTILQQFEMETKQNGAMPPPTAPTESVFPDFPEEKKGPDVSERSSSPTPNRLAIRDLRAICHGAGINTVGMERANLERAAAEVQKRGTYFAPPSAGHAAVPPIPPAAAAAPVGASTGSASTARSASPLPPKSSEPSAPVSNGATGHKMSIKDLRAICHGAGISTVGMERGELERAAAEVQKRGTYFAPPPGAVPPVAPRPGADAQPEDEAGKKEEIRQKQAAEDEARRRAAEEEHWRRHEEESRRRAAEDEHRRRAEEEHRRRAAEEERRRRMAEQQARQAEDQRRRYMEQQAAWQHQQQQEEQRRRLAEQQAAEHRRIHEENMRKQQQWGGQQPQHHPQGWSQHHHPHQHYQQHPQQQHWTPQQQQQWHQQQQRHQQYPQQHAPPRGPSPQQHPPQEQSKYAKMANQTDDDGQAAITKLKHDILIQWALQPPQLQMLRSVDVLLSTIQTVFPPALGVPAHDYFRKWKVVTRESVLSDVGIIDEEKVKKAVRKLRFFLHPDKLPKDLNKEQEFMVKMLWDITNDAWEEYEKSKADLDWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJP6</accession>
    <name>A0AAD2FJP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001145">
        <property type="protein sequence ID" value="CAJ1943830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="192" mass="21645" checksum="D2AC9D0D3DA8338D" modified="2024-05-29" version="1" fragment="single">MMLFQHNNTVIHLDSGSTFHLRTNEDDFKEGSLQGIHGEFHYAFNVEGRELYREGINKVFDSVCKLDTPASDNINSLSNMVKDGFDVFMDTKKENSFFVTRNGTTWGFGHRNGLCTLVDEPAMVTAMFHDHACRLDNDDVQGYCALQSVEKNKEGFTNKQVKQANVAQSGYHMMGAPGAELFKLAIRGNFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJV8</accession>
    <name>A0AAD2FJV8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="483" mass="54488" checksum="FAAC0FE2AAE6F013" modified="2024-05-29" version="1">MSENQWYFFAGGDRYAPPNVSHLLIASNVLDIPSSLCAGNQCLREVRFQPNSVCRGIGASAFYDCGSLELVELSPTVRLVGFMAFQQCPRLQVVTMDSNKNNNKNAMMNHQPQAITTRRKFGLGFQCFKNASSLTEVSIIEGIRSVSEACFEGCSSLRQISLPNTVEHLMKKAFKSCTNLEITILNEGLKSISDEAFCHCEKLQTIPIPWSVERIGTRAFASCTTLENVEIIGLDYRLKTIDEEAFAHCENLRAVPIPNSVERISSRAFENCTMLYSVEFKNGSHLWIGDDIFKGCSNLIWIVVSYSTYKRHYNRFHLLAEAFDRPAIDDDSRRNQNKTVLKMAADRFDSLQNHRTTYTTARHDHDDNIEIAKLDKTIQMYHREQEGILPKTKFVTGTTDINLFHIMASSSFPRHNLFHERLDSLNLGLLFEQDKIGLSPLMLLAENPSAEAQDLLLSLIPKLVAYFQASASERMATISISTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMI3</accession>
    <name>A0AAD2FMI3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMI3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732:SF8">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041980214" description="Lon N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="3">
        <location>
            <begin position="71"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="324" mass="36464" checksum="7EAB470FC2378FC3" modified="2024-05-29" version="1">MVAIVSSIVAAAFLTSRCYYDHANTNSSCSNKHSTSALHQHLHDQEQEQNNNGKESSPTNHPIILSSIMELPLFPLRKSVRVPSDSLTLNLYEERYLAMSESILHNTDKLFGTIYSSDKPQIVKQGKGVIVPLLEEGDVGVICLVKDDDWKDELVPTRDPLYQRRRIQLNAVAVARFQILEIINDGIGQQQPSFIQAKVALLQDDENLTRKDDRATNEDDEDDSKDSMEREMWKRVLAKEREIGATSALVDQVASLLLSPDIDDATKRVQSSCCCCSENDQIRCEAFSFAAAKLLLGASRPQQIQELLQMTSTQERLKRTLEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPA7</accession>
    <name>A0AAD2FPA7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001745">
        <property type="protein sequence ID" value="CAJ1948205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="172" mass="19356" checksum="54D1749BCA7C1C92" modified="2024-05-29" version="1">MVAELGQYVHAIGTDSSNLMEPQSIKAIYIEPTKGQRTGHRCVEAWAAAEGVTSMKFFDKKRDLETFQDGNQVAGVDDTEQGYLEEAFDQDYEPEDEDEHADNDVDDMPELTVRFRGDDDYESDDNLGDEGNEEEEPIVADLDHHQENVDRGTDNIGSLVTDLEDLQEPPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPX0</accession>
    <name>A0AAD2FPX0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001749">
        <property type="protein sequence ID" value="CAJ1948669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="25545" checksum="8884D7890547F28C" modified="2024-05-29" version="1">MAIGWKHGENTPKPLSITGADDSVTCTMHARNHNLLESQGCTLLGNIVKDKKKLLCPPNQVKLRLLHTTSPKCMYYYKIQKDHNGVFQLDKLNGTSIDFFSKEQSTVKTATSGSESVAAQTCAKQIMDLQQTLRYLGVLIRGQSYMLGDNESVMNSSSLPEAKLHNQDVELSFHRVREAVAANMLSFIHIDSALNPADILSKHWGHQQIWTLLPTLMFWSEDTADQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ15</accession>
    <name>A0AAD2FQ15_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ15"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF65">
        <property type="entry name" value="NIDOGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042077570" description="VWFD domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="399"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1948239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="971" mass="103607" checksum="D51AA6B2BE893F0C" modified="2024-05-29" version="1">MKVKVYLLSVSLFFSTLSVALAAGIRRPRSLVQERNKRGVQSIRMKRNLGKKTSTKSTKKSKGASTKSTKKSKGGSGVGNTLFTLFEAEGFTKDQAYWLDQITSSNKSDIDLFLDGDKAIEELQFFTNAVRSNPYTEGQEVSDREILNFLMGPTVFEPSDLDNEDNNNRGLQRSDPNNLDLRNDKVFVAAVNLGVEVLSQAVSEITSLPKGTLEKTFTILAKRLEPRAFFDFQDALKAAIRADGTIFRPAVLKEMGNFALTFLSNFSVKEIFAEVANNMTSVDYALWIGGLSANFASFFVGGPILKLTKLLVTLIDNASLAKAYADFVLAMVSDMPPDASPAPTGAPSPTPTEAPSPTPTGAPSPTPTGAPSPTFTEAPITSDDPCRGDPCCEDPSNCDFGGAAGDPHLVTFDNIRYSCQGKGDFVLFRLATSGLQIQTRFERLDQFVSLATGFAGTTGFSGHTIEISIPQTYAGKIDLFVDGSKLELGAGYDDDQFRVTVSGRTHTVFFKASKLSVVADFILIGVPHLEVNVRVPSSIRGDAISGLLGSPDGNPFNDWTTKNGEVLDTNFRFSNEDGYKYCTTEWCISDVSESLFTYNQAGDFLSLSGCDEEYPGSVDLSQASQELRELCGSNEACLVDGIVLGVEGAQSLLEAEASYGSSSLSNAFRASPNAVVADSPTDIVLTVDLSISDAPGSTEVEEFVVFEIDSETFEVSTVPVATLEDIGTGRGEDIVARDLIFSTVHSVESSGAAGSGFSFQAVPRINGELARDSPLVFTLLYAVVVYSVDSGIAFEVNRIKKGDTGILKVSAIEGLYLSIQYFWASGRSNTLVTGTSFLGEKVGSESSCPISSTYMYSAGTFDSLGSSAESVLVFFGDSHESGAWANQISIELNAHWNDGGGSGPVTVLVFPVLVPSALGSNAVDTEMLQFTVTPSEAAVAGCSTNKIGSVDVLVKPASDGDVTISVIPEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ46</accession>
    <name>A0AAD2FQ46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="210" mass="23229" checksum="EE4F6371C729D2F8" modified="2024-05-29" version="1">MTTLTAPHEGKNLLTPPSSTTCHGMSVMKRLNRRRVLQNKNEIVTLLVTPNDEEEIMTPRKLLATMSEYQAQNNNNNNSSNIHLVHVGKYIISLQPENCRSLAALFEEESNNENAENNPIVFAPTSYATPPRTTINNNNNKHFLSPPTTPPATKKPRTLQAPPGLHIPLPTLDEGTNNYVGSELGPTSLKPRNLNLTFHSTLFANDTTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ81</accession>
    <name>A0AAD2FQ81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="41"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="182" mass="20493" checksum="7EAA17BD6EC8462F" modified="2024-05-29" version="1">MNVESCADWAPIDALLERTDTSANPRNPVSHLVATTPTDSDIVFGRGSGSHNHHGNVSLRKEVKQLLVVHKKLPKPGKIKLVQDLIASRQSLGARFLEKDEAGDWYEVKDDPKKLHKKVSHCFRTEKESAQKRSEMKLAKKPATKQAKKPRKGNKQAKEKLTKKPRKERRQARNGNPQVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSE6</accession>
    <name>A0AAD2FSE6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSE6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="360" mass="40269" checksum="6BE4A1AD4D002032" modified="2024-05-29" version="1">MSSAREQQEEIWKRLIAAQNIEGSKSKTNQQEKWPSYNDVLHDVRKTDYNEILTCPADIHPISDGRDKTICPQGAVCCAKLELFSFPNDIRGKPYTGLLQPGSTSEHCIIRLSSALQPMNSSDQNNKLASMFLGKRLANAKLFPAAAIKMFRGNRIESGNMLFLGCKVGQEEEDFFAHCLCTQITSSMPTTLKPILKLFKKYSATPLLLGNSNLCSFDTHGEMSQDFNFPFCLTLRPRMESGARFLDEVLDIPAGTHLYDLFASPDPLSVADGRKLQRIGRIVTTSEMIPSTPNDGLFFRHQKKDEDFKFKPHWKSELQTKVTLKTGRKGTVASVAGWKLFEHQIADGGYIDFEASEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSG7</accession>
    <name>A0AAD2FSG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS13335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="9">
        <location>
            <begin position="181"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="383"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="494"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1951980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="772" mass="84688" checksum="5BDCD919421D0392" modified="2024-05-29" version="1">MTITWVVKKKSPTTKVGVTFISINKLVAIKSVSGRAAKLTDLVPGLRVFEINGKTVQSAKQACDIIRKAPIGDIRITTGGQHHSAVKISEERTGFTIRQYENKQDCVLITHVDPFGLFPDVPTGYFLWSINGKRMKSVNQTITSLKREKSVAIVIARPQDLGYDLGPLKPTTVKTRPIEGQKPGTSGLRKKTKRFMESNYLENFVQSTFNAIKARGTNIVEGTLLIGGDGRYFNKEAIQTIIKMAVANGVKRIWVGQDGLMSTPAISATIRERGPIWQQAFGAFILTASHNPGGPDEDFGIKYNCENGGPAPDILTNTIYENTTKIYKYFICPEFPSIDLSECGPTNVKSTDGMKQVCVEVISSTENHVTLLKSIFDFDAIRGLLDRNDFSMVYDAMHGVNGPYAKKVFVDELGQPESVCMNCVPKDDFNGAHADPNLTYAKELVELMGLDRKGAKIDTGAKVVQSFGAAADGDGDRNMILGTRFFVSPSDSLAVIASYAHVIPFFRSQGGLKGVARSMPTSGAVDLVAKDLGFDVFETPTGWKYFGNLMDSKAIFQGKDYTPFICGEESFGTGSDHVREKDGLWAVLAWLSILAYENSKVESSSKSLLSILAFDSSNKSSNSLVTVEDIVKGHWAKYGRNYYCRWDFEGVEKAGAEKMMDKMRESATANTGKEIGQYRIAKADDFSYKDPVDGTVAKKQGIRFLMEDGSRIIFRLSGTAGSGATVRMYIEQYEKEKIDMIASEALDGLVKVALELSAIKTYIGTDEPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSW9</accession>
    <name>A0AAD2FSW9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001795">
        <property type="protein sequence ID" value="CAJ1952053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSW9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="334" mass="36665" checksum="C05FF9045BD33F95" modified="2024-05-29" version="1">MTDVEGLDSVDSFANRTTSQVREDIKSMQRAPDPNNPNATIGITAREAMTIHRISKYGKLLILVQRTYTPALGTIPNLLCIGQFYDENPDLMEGDSYPLPPHSPKMENIESWACTAYGYCGICLDYIFRENSELPVVGDPGFLRADDGSRSIKEELVQILVLCSVATTRNFGLCSMPSHMKPMPTIMGHFTNELQAAVRVLATLHWNGKARGFTWNTFISRLIGAFNNLKLNRDPRSDAIKVDVLLEKTVGDSSLSNGRSHITGDAILRSNFQGAIDYLTTQVLAAGNNNLLLLLVVVADAVVMGEVGVVAKEMAPQTACNQMFQIALAAMVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTG9</accession>
    <name>A0AAD2FTG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ApaG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050718">
        <property type="entry name" value="ApaG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47191">
        <property type="entry name" value="OS05G0170800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47191:SF2">
        <property type="entry name" value="OS05G0170800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042289566" description="ApaG domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="ApaG" evidence="3">
        <location>
            <begin position="418"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="ApaG" evidence="3">
        <location>
            <begin position="633"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1952396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="775" mass="85955" checksum="7C2735CF5403DD62" modified="2024-05-29" version="1">MKPTYTAIAAFLLAQSSSVADAFSPSSLPITAMQPMPLRTGHSMVAAVQSQSRINSSLAMAASGDFLGMDEDDEDEDEDEDEDDQLVPAGYAGAKSPFTGLKLDPWDPNPLIKPRPSRYFKDMDEEQVSDDQLTQTMSDDERKENLSVMRQIRKSDLPDLRMRKDHAGWVEANNDLKRRYKRDPWFMVNERLRDAIQLGDPDEKIEHLRELAKKVGGPPEGIDCGTKGYAVHTEIYDIGISPSRAASLLDRDIRADRVARGRAMMAERRKNMETAQQQYEEDMRFPGLREDREAKERRERTMRRLMGEIEEDNKKKRDRAKELLGKLPEAPENRTKAMEKALKEAREDFKKTRREQLGREADDEVAEIASSNKGSGSSSAERAREAAAAEAAGGRPRLPGDEDVTKGEIDIPVEASSKTTTGVLEVEVSSTYNKEQSDPPMRKHCFQYTIRITNNSPTETIQLLGRRFEIQTVGSSMKDVVQGEGVTGRTPVLKPGEVFEYTSTAPLSVRPIGTTIIAARMRGEYRYATLAEGEETATEEQIKAGGELTADLGTFHFIFPEDQRVKPFRSSEEEDEEEEEEEDEEDVPGETAVAKPSSSTPSSSTASSPASTLPGDMDIKSGDITVEINDSSEVVAEEVRVAVTSSYRPERSDPALDKHCFAYNIRITNESKESIQLVSRRFEIQTIGSSSKDVVQGPGVTGRQPILKPGESFEYTSTAPLSVKPIQDKTPVVARMQGEYNFVTLSSDGSTPVSSTPLQAKLGLFHFVLPALSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTL2</accession>
    <name>A0AAD2FTL2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-pyruvoyltetrahydropterin synthase</fullName>
            <ecNumber evidence="4">4.2.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS13607</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.12" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTL2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042242110" description="6-pyruvoyltetrahydropterin synthase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1952546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="17453" checksum="40FB82C609D551E4" modified="2024-05-29" version="1">MIGRVQRCFLALVAATIILGVSAISPFPYSLGVRDSLMIAHSFHSHPKFGPAGGMHGATYTCDVEFLTDKLHPETNWVIDIGKASDIVSDVLKKYNLKNLDEIFGDNVMTTTEFMSRKIHDDIKSRLKDDCRDFDGVICVKLYESHKAWATYTGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU96</accession>
    <name>A0AAD2FU96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NAD(+) kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS14222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1953620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="48975" checksum="0B931890478ED070" modified="2024-05-29" version="1">MATSKLGRSPERRMELMFCDGDICKDAVRQRVIGKHNQIVLSGPATGQVAYTWSQDSTTNNANGERSNVTRSSVLLLVRPNDENLIKKVAEVVPNLTHAGVKVLLVPDLAAKLKFYYGVDDERIGLFEASMEFESRSSKTRHVNDSEDEWIEDVLIEPFPDLVCTLGGDGLLMHASMLFQGPVPPIISIAGGSLGFLTPFKVENMEDAICIALGMGNIEETPDTDKRSTHDIPVFPPNMESYPFDNPLSQASHPKFSFGMDEYICMTIRMRLDCRIVSPEGVVRSRFNVLNEVVIDRGSSPYLAALECFCDDIHLTTVQADGVIFATPTGSTAYSMAAGGSVVHPAVPSILVTPICPHVLSFRSMVFPDHVVLRCYVPDDARATASVAFDGKHRRELQRGDSVQIQMSNYPVPTLNRGDHSSDWLEGLKRSFNFNTRPRQRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWB3</accession>
    <name>A0AAD2FWB3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWB3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="460"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="575" mass="62631" checksum="F2C56D1D7A23877B" modified="2024-05-29" version="1">MASAAVIAAVHDRDFPRLIEFLRIGEFTIEESLGGNSGWTLLHSACSNGDVEMAEFALNHGADTDARRSSNGVTPLHLVSFMGQVQVTQLLLNHGAGIEATTSDGETPLHVAVTEGQVQVIQLLLNCSADINAKTDDGRTPLHRACRQGNVEVIRVLLDQDAEIDARANDGCTPLHCACRQEVIGVLLAYNADINASTNDGSTPLHCACRQGNVEVIRVLLAKGAEREARTSDGFTPLCGACIEGNVDVVRVLLVYGATKETKSCGRTPLHFASGMGHVQVIQLLLNHSADVNAKTDDGSTPLHCACRQGNFEAVRVLLAYDAEIDARANYGSTPLLCASLSGNVDVIRFLLNRGASILTSAKYGFTPLYCAALQGHAEAVRLLLNRGADVEARTNSGHTALHSASNERVVQELADHGANMDARDGFGFTPLYHAAKDHRLGVLKKLLDRGADIEAQDRWGRTPLAFLCHYGFVEAVRLFLDRGANMEARPIPGLTPLDWACRSGCVEVVQVLLNRGAVYERPIDEMTPLHYAAIQRHREVVWRLVRRDPILLLNMPTDSPQVRETKRRRLRYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY75</accession>
    <name>A0AAD2FY75_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="518" mass="59514" checksum="76F7B7211855F41B" modified="2024-05-29" version="1">MKVRLREKYKGATKRRLHCWLCLIGTMLMITLGWGKRILMQGIILPDDISGSDRWIAFTNLTEKDLTATSASSGTYKSSVSSLPHFLQTTLDQSDFVELDHCDMISLNWTLFQSFAEPVIQSNLPKRALANDTEGLETTKLRNEWTLELLELYLTHNGKCQFDQYRPRIKRVASIQKAGWKLQEIAKVFPVPPQQARVVFSIVAYKDSKHLRRLIEAIHLPHHLIIIHLEQTQQGDESYHQQVEAIANDYQNVVVVQFGTIIYKTDSISRVTLQLMYWITTELKIKFDYFASLGGAVYPLFGALELSKHLYESAGNVWLGEATMKGRRVEAPQTHLLWKHRLLATSTKLAIRTGTIFHDIVPDWMTETMRHKSNSGNQAIFGYSAVEKMLQSEKVLQIFAMAKYSCCCCVEERTWIAAMDIIGFLHEARKQSNMFQLWGGEENNCVGSMNNAVLDLNENRCFRIEALGKAEMYFWGNQTWDNIVEAKKNGMMFARKFSSDQLDSIQLLEKIRKELHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZF9</accession>
    <name>A0AAD2FZF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS16970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1957975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="602" mass="68205" checksum="57823F8DEF108EB6" modified="2024-05-29" version="1">MNESESKPLQWWTTYWIPLHIGIRIWLANRMPIMDCDEVYNYWEPLHFLLYGSGFQTWEYANQFALRTYSYLMPMLGLAKVYQALIPYLPAWCWPLLSDQMAVVLSEQQDPTNNSNKVALFLLLRSTLAASMAVAEVLFCRSIITSTTTTTTTTTTARPSATTTSIGETVGIVTSGLLLTSAGMSHASGALLPSSTLTFLWLLGATAFLQQQHLFFVTVAVLATLAIGWPFGVLMFVPIGVAILVRERNNLTKFISKIVLITAVIQATVMLIDYQQYQKLVSPVWNILIYNTKAGGDELYGVEPWTYYIKNLLLNFNYVLIGVTGVLPLFVLKQDRRMQQLLILLLPMYAWLLVVAPRPHKEERFLFPIYPCICLGAAMSTVTIVDGLLSWWHSSPQQASLKRRRTRLLWIQLLLWTPSAILSLSRATALAKYYTAPLTVYSKLQSDPDIVDALVCTCGEWYRFPSSFYLPSTIDSFGFVQSSFEGQLPQFFTVDGSGPRSPNQFNDKNLPEYGSYVSLDDCDYLIDLWTSDCRENDFIWKPIAQDSFLDAERTSTLHRTLYLPFLHEQAETQGGTTIHLRVTFRSQCFMRCLQLAATGFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G029</accession>
    <name>A0AAD2G029_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS17377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G029"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="9">
        <location>
            <begin position="17"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1958840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="721" mass="80035" checksum="ADAE1D808CC0F1A5" modified="2024-05-29" version="1">MNNQNHHNQTRNNNRIVLLFDLDCFYAQCERVRLGLPLDTSLALLQWNSTLAVTYPAREFGIQRGDSWDAVAQKSKGKCHAIHLHILQSSNSNSSSSSSSSGSEKGGKNHENDTNDDEENKEDDIGMEDQDADYKTAFDKIYKLTPPQQMEERKQLGVRKHYYEGKACLERYRLASMTIFSVVLESLTKHLGGKDHFVLERASIDEFYLDITKYCYNNDGSDINNEGHVQTSSTTDDSSKASTSTGKGKGIPNQKPTVVVGDSSIHNEDDEQSPLKIALHRACQVSQQIRTDVWNHLGFTMSAGIATNKMMAKLAAGYGKPNGQAVLHPNNFETVMETTKIRKVRNFGGKLGKKVIHTVLDEKKDATMGDLAQVPLPVLLHHFSQETALLVFDACRGNDNEQVKETTGALVKSITAFKSFTATNQVAEIQKWLNIIANEIVARVAKDKVRNKRYPKTCTLNYTYYTTRNGQRPNDGSHRSQRNTKSVRLQYPNEGMKASKKAETLQEQAMEKLIPILQKQKLRGVGMSANNFEPMGPSGVSSIENFFSSSGGAETTKGGDGRIASSHRFSNHPPQQQSMLRSDGVEQYFSSKSDMIAAESLSLSEAKQGPLPSLNNDDNDPRAITPDGSTEKSDEELAKELQASISKKDNDDSSSSSNRPPLVVSKEPPPTPVDNDMELARQLQAKYDRENYVLTATSRRSTAGGPPRKKARSIKTFFQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0B8</accession>
    <name>A0AAD2G0B8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0B8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47832">
        <property type="entry name" value="DNA PHOTOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47832:SF1">
        <property type="entry name" value="DNA PHOTOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041990322" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="447"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="881" mass="95786" checksum="425AB554A2AE235C" modified="2024-05-29" version="1">MKHHDIVHVLSLFSLIVNISQAFVSVHPRREESGHHLSSIFAASTSTDDITALDVVLFGIGDLRTDDHLGLIQATESSSFSRILPLVVLDEESISKVPGVVSHTFDTASMIAETVNDLKVTLARSKLDLQVSVGGPSLSEQLIKILENFPAEAVIRLHVCDAGDADNVMGYAPISNLDGLPENVIVKPWSCHLWVQPWSNVASVSKRYPDFEDQRKDPPMKPVSFNGSTVNGRGVSIAELTGIPTAEDIYKLLQTKLSLDDDRCEAERNSGMYATHWGGLESSTVVESKIQDTIQTYVEKCQEDDEVYAKIPVLCTRNPQSLEHASMCWNMRGGGESEDQPVPNNMIAGERMNRQLLAPLMLGTVSPRRLWHSMKKGSILFKSPVKTLVETREWHKLLAARNIQTDSQYQEESNESTKYKYWRWHGLLCRYAEADLAKGANPGSEGVVLVHGFGASGAQLTKTIDCLSEKLSGSTTVGKCVAPDIIGFGESEKPPVTYTGYMWESFLGDFIKDVATTRCQMDSFVIGGNSIGGFISMCAAANDASIDPTAISGGGSPGTGKCNGVILMNPAGVIQAKEDVVAMEQASNGIPLQSVAQVTATDGLPPCKPLPRPVARAFGTGLLAYLRPQIREICIKLYPTNPGAVDIFLCENILRDSLDPGAINVMISGSKLPTPRTYNEVIAADFGQASDTETLKESTFIGPILVAQGILDPLNDAKGRAEALKKLRSGITVDPLQAGHCPHDEVPDQVANSIATWLEATREERTAMLQNAKDQADKATTPEEDTAVVPKAKDEAVEATREEKIPLVQEAEYQAVKNVLERIAMPPKTEDQPVQITREEPIAMPQKSVDPTVKVTTQEVETPAVEKAEYQAAKSSIEYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1A1</accession>
    <name>A0AAD2G1A1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001928">
        <property type="protein sequence ID" value="CAJ1956964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1A1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30046" checksum="CCDD4E530C46A850" modified="2024-05-29" version="1">MSVRQALEFDQENGNNKWQEAMKKEIAQLVALNCFTFHASNYIPDADSQEAKFGYLKKYKTKQLIIDSKPMKIDPAMFNPEDPDASFDPDFLNEYPDAGEERDPQEPAAFGTELETSILFDANHGHNKRTRHSISGILVYIGSTLVLWSAERQGFIATSTYSAEFMAMRTGVEEAISIRYMLRSLGVPVTKPTHMFGDNMSVIKTASLVNSELKKKHIAISYHMVREAVAGRVVCLIWCNTHENWADICTKSLGGNAFHAILDKNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1D6</accession>
    <name>A0AAD2G1D6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS18046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002013">
        <property type="protein sequence ID" value="CAJ1959627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="905"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="928"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1342"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1450"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1369"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1388"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1483"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1536"/>
            <end position="1546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1959627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1553" mass="173080" checksum="BD8086B56028D9EC" modified="2024-05-29" version="1">MSDPASSTGTPPDHSCDTSILTAKYLMRHSSEKDLIHRMRKILQVLQHDECIEANAPEYPGLAGLCLSLTQFVDHQDKESDTLKIFRQTIRQLASLAHTTSPKQPNFHSYMRILELLAEVKIAVLLVELHKDGNEGEALSVLAELFRTILQSVRTHHPHEVFEMTQKTISGCLEEYGEGVLIPTALLDELLICVGQGPIVLVTDPSKAAEVAKQQKSGRRTKTWPPHQVEQENPSYVVASAIIRKTVDRLSTPIANLLNGLLNTDPRVVAESSILNTVPGEFKLNHPKQQDQSAVANVWNVVYEFHRIAPSILTTVIGTLSNYLTSPELEQRLMVVRLLGRLFCGDDAKLAVQFRSCFREWLRRTNDIDPKIRLMMVEYLLILISSNVTEVSADAQHILAKQLTEDSSHLVRLRLIHGLCDVAHEHRDILCQELWKLVGSRVSAKNKQERKDAVTGLAQNYFTNYTAYHLLNVQDEGDDCSLDTVRKALRTCAQQVSEDNYSWIPDKIFQAASFGDTVDPDLRNRVFLVMDEILLGSELPNSSKRLSATTRSAGLAILVHSLKQESVSNSYAWVGDLLKQRSRLQKASREYLGARRKIKEHPQGSEQSMAADAEALDKLEVMACMTGGRSMGAAERSPILESFHRAKDKNIFRILATISNATHSNISRSVAFEELPKRVKNMGEDTVKWVKTLVRRCAMGEFINKEVVRHCILLADECFQAEDIESSQKFLECVYLAVESFPELCSTTECFGTLIELFVSCRMVTCNKMSRLITRFGVLSTLSAILSSISPHVKPGMIDVSRTASQHLFDLCSVDGTPEQARHAVGTIANLYGVKEMGSLSQEQNDAFTELLDSLTAPSKLFLSDNSDPRLITILVALAELSLHSSEVFHSVKGRQSIQFALDLIRFGRQGSGKGDQIDTSAHVEIDQATPSNQSRRHRKLTSQQMEAKLSDPSSTDSIIDDSSLSVSCRTYCAAIQFVTSFIRADCISLKEPPKDSPRVHNPELEEQMFDLLTRIILDHGLSKLHINELPMEAEERRALKQCACICVLRLCDPRLRLDRRHLTTERWHILAETFLEDEREVREALMKELSLMLTGNGSFGNFRGHSAMVPLLRLIAFVTLCVDGDNGLSSSAANGNAANVGKTALSIRYHTRECVIALRKAFEATAVQARAHGAEAEKAFESKMKVSLMPEFVVLYAFHLLSFRPETPLCWSGSSSQVNLNSEVHVDENGERILRKRLKWLFDPLVLSLGDSADNISFLLRMTEALGSYEPIMHTAYSAIKKGLVYRPNTQNQHLAPSKLKVVCLAAREVLLSYVKNDVNLAFYPGQISLPAHLYQRGQKHITSRDSVSQVPWKEQDQPPDLSNLPISNGSKSSDSTSVDSNLGSHENLHSLERAESQSTSAQMDTSEKASGISPLPTHRFTQYNGLDSEDIAPRETSSIEGWANSEIDLTPSAKDGSPNNETVSSKLGKRSQFARRPDASKRHKRVQPRLRARKSTRILSGKKTGMPYMSIKLSESGSTALKSAAGKENAKQSKSTKIRRSPRHVAKEPMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1P7</accession>
    <name>A0AAD2G1P7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS18255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1P7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF30">
        <property type="entry name" value="OS06G0587000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042035763" description="L domain-like protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="218"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="497"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="615"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1959836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1004" mass="101786" checksum="0DB08B79C7532B34" modified="2024-05-29" version="1">MVKIVVDSALHVCLVLGLVSSVVTAQEGTTNADPLVKGPLRHRAARLGSRPNLFNLGDFWKQAKSDPAGTLAELEQTKQQADTDIEDLMGMILESGFSMDNTNPPTLRSSTSRAPTGMPSRAPTVAPSKVASSAPTTMEPTVSMAPSTTTADPTFQPSELPTDLPTASVRPSMAPTDETNAPTTSSKPSISTKPSNVPTNPPSVSEGPSVSQAPSGRPSVSAAPTASTPSTSPTVSGSPTVSMQPSSNAPSDAPSMSSAPSEQPTEAPTEQPTKAPTEQPTEAPSEEPTLVPTPSPTISTAPTIAGGLPVPSKNPSQSTLPSLAPSVMASSSPTLSGQPTLDLVPSSLPSSPPSISMKPSIAPSLSATPTSFGSTVPSQGPSLAPSGSTKPSTAPTALPSIVPTTSKMPSLVPTRALSDVPTGAPTVSAGPSSLPTVSVAPTSAPSVSMGPSEVPTVSTQPSGAPSTSTRPSKAPTVSMAPTSAPSVSMAPSSLPTVSPQPSGAPSASASPTSLPSVSVAPTSAPSVSMAPSSLPTVSTQPSGAPSASASPTSLPSVSMAPTSAPSDSMAPSSLPTVSTQPSGAPSTSASPSSLPSVSMAPSPAPTNSFKPTGAPTLSMRPSSSPSVSSNPSSLPTLSTQPSGSPSVSSSPSATATVSVRPSATPTTSLVPSSTPTVSKQPSLAPSVSAAPSLLPSNAPSDSSAPTFVPTLLTCGITVEQRSVDIRTNILTVSEEALLDDPLTPQGQALAWLIEDDDRLLCPPDDLIQRWAVAVMYFSTNGDNWDQCSDVGIDLCGSQDPFLTKRRFLSSFNECQWAGISCNIFSKVTEIEFEENNLVGTIPTEIGLLTDLAIWGMERGGLTGPIPSQIGNLSNLVFLDLDFNDLSGTIPIELYSLAGLTQFDVNNNRLSGNIDQIGVFEQLEFLQIHSNLFTGTIPASMGALTRMTTFTLHGTGFTGAVPDEVCTLRDINGGLLSSLIADCGIPIGAVNPEISCICCTDCRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3A5</accession>
    <name>A0AAD2G3A5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS18844</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3A5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="134"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="241"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1960688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="333" mass="35387" checksum="A5161D77D1AB0D9F" modified="2024-05-29" version="1">MAPPQDSNNQQPLATMTATSSATTVATKTSLPPSSSSAPIALPTRMVLSAFAGMGAATICHPLDVIRVQMQTFSYRNTGHAAVSIYQNGGLVNGLYAGVSAAYLRQWLYGSCRMGIYSYLLEQEKIKKGGADNISFGTKLGMGSISGGIGSFVGTPSEVALVRMSADSKLPVAERRGYTNVVNCLQRIASEEGAANLWKGATPTVARATLLSACQMGVTSQAKSYLAKQEQYFGKNGQWLGGYPMMLCATLCSSFCANIVANPFDVLKSRIQQDSKNLYSGMVDCFVKSVKGEGIFVLWKGFTPAFVKLAPYTIISLTLVDKLTKAATGKEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3S1</accession>
    <name>A0AAD2G3S1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminomethyltransferase folate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS19345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3S1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1961735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48300" checksum="6105F48AB53E3CFE" modified="2024-05-29" version="1">MASSKVTSLAGNFGRLWRRGNETLRNRRIFSVKGKGATNYLQALVTCDLTSPPIPPKEELEPDPAVPQQQQEEEEHPMVEFSEKLRSTCFLDNKGRILTDSLLWKIDDTEYLIDIPDNDSADQLMGHLKQFILRRSKVKVVDKSDEISAHVVFGTMNAAASPQGFLAGMDPRHPSLGMRVLSLDAEKAKQFEDSMSSNFPNAPGNYQLVRKLAGVAEGTELLGKVAGESNQEFLNAVSFAKGCYLGQELTARVQYTGAIRKRILPLFLTDLNMEIPRPWLMASQVQLGKTPEGVEVGSASASMLPRLPRLSAAAAGGVVGIMSGDMVQEQTPETEELRKQSEALFQEVQNYKKGDKIYDVKDGKTIGQIVAGAEEGTNVLLAQMRLDRAGLLGDGVWSHTNKIRIGDHDNQLRYLPYLPLWWPVIDRKSGKAATEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4B6</accession>
    <name>A0AAD2G4B6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4B6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="228"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="385" mass="42555" checksum="AD70EDFB8A993AAF" modified="2024-05-29" version="1">MPSTSTDKIANEAILFQAVQNTNKLSVMLRAQGDKHPSLARLRRYVGEVYSSLWDVAMASGTPDFCDVVVYPQNLPNAAPEQWIHHAADLDSVCSHDSICGWVSSSALGRGLQFQSNEGDGFGGLEAHVQALNADRTQRKLSPLQAISVDPWPLGASAAAQKDSFVDWLDDEHFEEENADIQNDDNLFVDDSMDDECDTTEEFDPESACDQLGGARIPRNTLYEKVAVGGTFDGMHYGHRKLLTLAVSSVNPRSGQLTVGVTVDAMLQHKKFAEEIPQLEARMAQAKEFVYRLAPGMKNRVRVVAISEEYGPPGTEGEGEDFDALVLSHETLENGCLLNQHRINTLGYKPLKLLCTRRTEPHGMSSTALRRIRWQQQQEAAKTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4D0</accession>
    <name>A0AAD2G4D0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4D0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="489" mass="56283" checksum="5C4B3495EA7E32D9" modified="2024-05-29" version="1">MEEAASLVQGKTEVKNEATIEAENTSESQARDDDADEHQDAPDTLSMSDFSRRIHHPFDYKITLPFLYGNDDEGNARNAPESSLSYIPWRLRLMEQVASSKKGEANGNTNEEKSSDDNPTEDSLVFSPCTYLELRRQQNDAWASDRLKEGNEQLFINPNMAETKFLEGLDLVPDHADLLTAHAKLLITNNDFAAAETKLKRALETDPDHKLAQKTQLELVRIKEGRMRMEQQQQNLMLRNNAPKYDFLSSRNVEVAKGNSAYNDALMERALVMGDDADCGGNVASDDDDSSRSRRRKKKSKKDRKQKKKKRKRHRRKRRRRYYSSESDEDDSSRSVVSGGDASDDCKKKENGDDRGDKGNILQEKDQKEERSDVDSTEDRRRRKDRKRSRHRGKRRRGRYSSESENDHDEDGSRTVSSKNGGSHDEDAVRKNINENDVGSKGGGTAQENQTEERSDDSSRNDRRSRKRHRHRDDRKRRSHKKHRRRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4I5</accession>
    <name>A0AAD2G4I5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4I5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="53962" checksum="4153C5DEDF6B499D" modified="2024-05-29" version="1">MAILDVDMRSDEDAKLRTGRSSNSDHCSSNLNTSRQTVNTHNSILDISRDEEEDEEVKSVLFESLTVVSMDTSDDENASKGSSSTQSSKKFSLHTFLGDKFMDGLCTPEFVPSGPCAVPTDCGQRMNCTRPRMSSSRRSRRNQCDDRVNLSTDILDLLGCAADPGTFEREEIWHKKLDLSKPTRTNLKNRLRRIRELRNSAHRSQTSSRHGVTLSHSRKRCYGYPSILKRSATSDEHDPLSQYIGKGMDPIVPDYDGYDSDPEVLSNQYTPRSRQSVPADTIQMKASMDEDMYLQDLVQQTLNKTWTFTWHPNPHNVKEFGLDSDRPICINIWIERGTALPNGHVAEPTIMWRDAYQPFLNGKHQLNKSTQKPWNMRLLSTCRIAASGKLDRSIYPLARSQNCFVLKTSSGNHEFLFEATSSNDMRKVCQQWKLTVARFASLAVMENIASIEREFFHPSFNNQMLTVDSSSDEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4U8</accession>
    <name>A0AAD2G4U8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS19956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM151 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4U8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026767">
        <property type="entry name" value="Tmem151"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041990323" evidence="8">
        <location>
            <begin position="24"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1962991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="375" mass="42076" checksum="DFA80BF01F09DB95" modified="2024-05-29" version="1">MKSSPIRITVAILLCGPIISTVATRGGSLSERRIVSILPKEEPKVHGIFQKHGGSAELFSLPKGSSPLSVPSDTTSTTDTQLPLHLSSRTRHISHIVASIFTVFLFGSLVYCWKCMGSDHDRSNVGLILSFMSVVAYFMEAATSSTARYLRNPLTPDDVDEYLDSIKAVIPRVIWDIECFHYETVQRVEYPSSSNDDKDNNDQNVPEVRTETETIVTHRASAEYSFARCKDETDTRSLSRMLTGGGTDNIKGDDSSTQAQLSSIPKQFTKITLDKLLFFANDATYCDYMEQESRFRQLHQHRDLHHSFSSRLVMDGYLPKILVVNHSLGGAGTGLIKNLWYWIFTCLGLTVPYRIWFSQHCSNTEVTITKEVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5X9</accession>
    <name>A0AAD2G5X9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylamine N-acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5X9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.10">
        <property type="entry name" value="Arylamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.150">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31592" checksum="C7AABADABBFE448D" modified="2024-05-29" version="1">MTTVNLAKYFGRVGLRDLQPPYTADRDTLKRVMEAQSKSIAFENIDVVQKKSISMDLEDVQKKLVEDVRGGYCFEQNTLLKAVLEEMGYSVEPSLCRVRWGKQDDSAGPNTTFTHLVLKVFTKDGIFLADVGFAGTNSIEPVRMDIGGENQELPEGRFRIVPSKHKGFFVLELLVKGEWRPLYEWRDEKAPLVDQECCNWFSCTNPKGRFTSQFFVCKIIGEERHHILNDQYVIRKGFGANSQVTTDTISDKARLETLVSDVFGIKLEDTSGIDRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6A1</accession>
    <name>A0AAD2G6A1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002127">
        <property type="protein sequence ID" value="CAJ1963051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6A1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="201" mass="23086" checksum="E18BDC88A0561A65" modified="2024-05-29" version="1" fragment="single">MMLMICRNLLSDSKEMMTMNQMTTIRVMKAMKRKNLLWPIWITIKKMLIEEPMIFGSLVTDLEDLQEPPEQEIVFEPETPQVAKVTRSGQTYAQATMSGLNLSQVPKKPREWPSSRSGSSANKNKNRVATRRKHQEREMKQLKDKLKSGIRTKEGSRSTMLDDMGVTIDPTAAGDHKPTAERNNRTLKERVRVALARLPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6G1</accession>
    <name>A0AAD2G6G1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS20069</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6G1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12974">
        <property type="entry name" value="Phosphonate-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042058038" description="guanylate cyclase" evidence="14">
        <location>
            <begin position="27"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="620"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="16">
        <location>
            <begin position="1010"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="653"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1963239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1191" mass="130199" checksum="3D64C6C7363AC329" modified="2024-05-29" version="1">MIGMMESSSILLAVGLFLLLAQAVSGTRQLQQQQQCDSCAPPIPFDPSVHKPVYKIALQPSVNLPLMRSLNVTFEDYLTATAGKRFDPPIQFEVMIITNSLAYDLMKSQEIDFIFINPFQSTCLEEEFGAQAIASSVRTTSFGGQKLALAHFAGMVITHVDNNDINTLADLKDKVVAAVSPAALGGPLVQWHEMQKNGMSYLNDPAAIVFTRSMVRSINGVIDKTYDVGFIRTNFMESLKERNPGLNTSAVKVVGIRKDEGTVDEAFPLEHSTSIIPEWRLSAAPSTPASISKEVQAALLALKEHGRTGLARSACLDANGNNTAQCDDLSDIDSQVLCEANIESVSAAESVVSAKEHNTFRTPLSFHRIRKMALDLGSILEDPTSDSLKCFRPSEFYDQIVCQNGLFKLSPDALAASCNTTGYSCPDGRECICKPCFKALAIEVAPTDQYAAGSGCTKMSICSTIVQNEVIQYTVVDNQQLEGGRNLRAKTLEDGTDTEIAIEQGPIPHTYSFSLSTPRVGIFILEIYDGDEQIDASPLRVRVDYRTCSGDKEASEDGVCECKASSIDIGGTCVPIWLAVLVALSPIAIVVAIAVYFFVKRKEREANSLWIVKRSDLKFSDPPAVLGHGSFGFVLQAEYRGSKVAVKRALLPSSKGDSSSTDNVQFGTPLKRIGSQDYDEDSADSSRRRSTESTRSVDLEVGATKNRAEPQPALSTRNITASSKSMMMTKGAANSRKTKQLFMDEMRVLSTLRHPNITTMMGAVIDGSEPMLVMEFMEHGSLYEVLQNPTIALESDLILHIIQDIAQGTRFLHSSNPPVIHGDLKSGNILIDSKFRAKLSDFGMAKKGKRIATGTPPWMAPEVLSGKSSNTTKSDMYSIGVIMNEIVSRKEPYHATTDPLHVIVNGVTDPKVNRRPEIPSFCPVKVKKLIMFLWHADPKLRPTATELNNRLDDLNEQVFAACAPTKALHRPREVPTGGRDNFLYQAFPRHIADILSSGGKVEPEPHNDVSICFSDIVGFTTIASKLDPLKVSSLLDRLYLKFDEVTRKYDLFKVETVGDAYMCAGNLANDQHEDHVRRIALFATGICKAASETLIDEDDPSVGYLKIRVGFHCGPVVSNVVGSLNPRYGLFGDTVNVAARMESSGAVGRVHCTEECAKRLINDAPDLLVKARGATLIKGRGRMLTYWISEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G782</accession>
    <name>A0AAD2G782_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002176">
        <property type="protein sequence ID" value="CAJ1964186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G782"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="366" mass="40559" checksum="2FCCE4F6FA302A3F" modified="2024-05-29" version="1">MLLLEPKSIKNSHAPSALYIYKAQQQCQQTNELEEEVPKDDNEHPIVWDKKTAATAKEKKSRHHQQIQLTMQQSPTVVFDLATAQRVITTDEKSPRFWEFSLMFNPTLIVQRAKPLTWMWLAASEFFAHPWTGPAIIPPIVEEFEQLEQESKIAKAQSKSKKRPASTPENPKGAKAHDSRPSPSVPMQTELTPPKGPSKPYQRTPPSDATPPCQQVVMSDAVHVIAGTPTETQEASVPADDVVVANTPRGRTSAENGAEEHNSAPTYRDTVATLPAPTVPLTTDERLMRLLAVHWNASPFRHITIFNVSIVFDWQGVGSSEFNQVQTAYNAFHQFASGIWGEITSKVVLLPLLMADSPNNNCGSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G830</accession>
    <name>A0AAD2G830_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G830"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="116"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1963173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1099" mass="122924" checksum="81D65F4479D0EDF6" modified="2024-05-29" version="1">MTSKVAIKYHDHDTLTSKSSLGSSQDYTLSIDGSQELRSVKRGRGLSIPDDNDAFDLPSSHRSRSRSGSTDELTINKLKYDEDIDLVGRNEQKKILHDCFERMMDDPSSSPSSGGHRSRRKELVLIRGHSGSGKSSLAATLKKPISAHAKGVYVQEKFDLYFIEYPFFAISKAFANVCSHVMTMSTGANEDLADSIGQALHDELGADVESLSRLVPEIDELIPEQDASVSSRGTTEQYDFAAGQERFKFAFRVLTRVLCKFLSPLVFVIDDLQWADAASLELIAALLSDVQNNKPSLMIIGCYRSDEVEKNSHLADMIAAITKKQEPCKINVTELDLQPIDVDDVNKIILALLGMDDAERTRDLAEVCFHRTLGNPNFVIEFVAMLEMEGLLSFNLGLTKWMWEAKKIENETMSTANVVELLIARLQKLPDETQVLIQYAACLGSTFDLKTLEILWKDHGARTCGCKDHLKLLQDGNFIESVGSDSFRWIHDSLQEAALVLGKQDKESLQFSIGVTLYNALSAKDGGLEDHLFAVTNLINHGVNQEKVEFAMLNLRAAKKARSLSAFKSGSSYAAKGIQCLSDDCWTNHRPLVLALYSIGAEMELASGNLEAVDEYSNEIINRDYFDILDKMPLYKCRMYKLATMDLRHQDAVDCGLRILEELGCQLVKSRTFVGVQAVISAKRTITKARNTSMEAYLSKSMDDTKLKEVMLVLYRMTVSCYFSGNPMIMILCITRSVQLTLDHGSSMMSGAALVNLAYLALGISKDFKAAGYLAEVAMILAKKGRSQYVEALTISNVHATTIAWTTPLQSLLNPMANAYTLGMKSGNSETAMWSLFFHQFEIPYVMGKPLGPMLEAFPNALSQCEEKKQKDQAYIMRMFWQMMLNLADDNSQGKEVLEGEIYSREEFPPQSPLHETHFVLVQMNLYIFFGNFEEAAKLALKVGGSFEATNPGIFPNMMETFHRGVALFAMARKTGGKGKYRSPAIRIRKQVDAWLKADNPNVLYFHHYLCAEQAALDRRYDEAERLYVEAIKIAARSGALHHAGLFNERFASFLREEKKMPEEAEYRTKEAEKYYQNWGAMGKLGVSGIEKLFSGSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8A3</accession>
    <name>A0AAD2G8A3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8A3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="355" mass="39385" checksum="B124149CB91BBB41" modified="2024-05-29" version="1">MPSSVSQLKHHKLSNPPLRRLGHQCYCLIALILLSSSSSPSSSFPSVASAANTIKDTPVYGHDDAIFGGIEEQQGDKPFGNVLDAGTGRYSLRWLSTLSLGSKGMTQLTAITADDKMLQSITPLVKKLGIEDITSLVIGNWFGEEEPIPFENDQSLLLFDTIIADYLIGAMDGFSPYQQDLIIPKLAKYLKPGGRLYIVGMEPIPDSSVNKDEDIICQVKRVRDACLLLAGQRPYREYPLEWVTRQVDRTPGIQLVASNKGTTKITATTTTTTTTTYPIRHSGRFIIRQINNGRRWLKMIKPKSLEQEMKNLLDDLENQALEATKDGKKIELSFNYVVSAVKLEEVIIDAAFYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8V6</accession>
    <name>A0AAD2G8V6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8V6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="730" mass="80569" checksum="A807C5BC8D8F5F02" modified="2024-05-29" version="1">MTMETLTSSPNQVTPHSPMDDHSHASTMDHSAIMTTAVNVAESKEFWPPPPPVSEDDQVVGEVDETTVYETASTDSSEVEEMSIKEEDQEKEEDESPVRKAPEEPSKAPKQEQSLQAESSHSSYFPVISLHDSQHSIVSGLTAFDRSAHKSGSGDKVDRLREELSMLKLNVLKDGHHFSKEEIVNVLDKIQEDLCGGGGGKPSSQLSVISSDGEDSSIAGSEYGDDSSSKRRKKSKSLPPVERGRKKPRKPKKNKSRDVPPSPKTPRSSISKRGKRSSEGSSRRKQRTIKAQSERSSRSLPVEDGFNSEALRKILKGEGTSKMSTLREERSTDTRSTKSSTKSKGRSSSLNPKSRSNSIAAPKMGRKPPDAVAADFSGQLNDTQGLKKGKAPRRKSAPMMGADFDHLAVLQQAAIFKTELNDVEQQQEPRRRERKQKGKAPRRQSAPMMGADFDVFAARFQEEKQQQKEQRASGDDKTRSSTESASIAGSSVNTDNESAATNKKKKKSKKIKSSRRRTMSAVYTDQSGQLNPIDLSARTEGEDSSVGSFTRKKKKSRKPKNRHASMEVLPSNLSQPVKLERHQTFDSVISRLQQQQQTQETSVTPKQSRRASISDFTKFSEHMTVDSLEEEKTNNDNRNELNIYHSPKKEDPEASDDMSSRVLEDESDSPVPPVTRSKLAQAKRKSTQFFSKVGSAASIITSPRSARRKKKTSLGKSSLTIPGLNGLNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAQ7</accession>
    <name>A0AAD2GAQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS22766</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF8">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042084141" description="Sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="61"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="322"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1967420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="559" mass="65391" checksum="690EB35662CFEEDD" modified="2024-05-29" version="1">MRIPLSLLLFVIFCCCILQSHFSLGEIEVQQQEKGGAEAEAEEASSEEEEEDGVQYFYHDFPDAGDILEYEAPIEGGEWDGISPDYIYQPDKVRGIRIVEFYAHWCPHCQHFRDHYVRFAETLRDIVHEYAPGTTINMFAVSCVPWRPVCVDFGIEAFPKLYLFQDGSKEGREIDQNDVHPFKILPLLGIHLDDSLTLTQNDEDKQVELVAKGNEESNENSSKQFWLPRTKQDIYNDAHLSFDFAMRNSIFLENKPLTKKSAKAFAHWIEQLVSAVPPTWALKTCFAEIFESIDKVVQSEKALLKIVNKYPPKKKHWSRSCTRGDKYAGYTCGLWELFHIMSVGIVEWNVYSNGDDWYFFRPEESATVLRNYIEYFFGCEVCRQNFLHGFDSCQYDRCSRLIPEIGDLEEWKEIPLWLFETHNGVNRRLARERAERENREITQEEYEAVKWPPRHECPKCWGEEGSWNSENIYNYLRVTYWPDDALNVKMREFVTASVSSEDDDELGEGEKEGITFFGFLKRLLKAMGCSAVLIYATYFLLRRRRLYRTGHHKKVDYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB44</accession>
    <name>A0AAD2GB44_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002369">
        <property type="protein sequence ID" value="CAJ1968171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="456" mass="50704" checksum="4314C4873A340A5C" modified="2024-05-29" version="1">MSRDSRVSNGLKVTATTTVTANDTITTTTNKSNSNSNSNNSNNNNNNKDESSYNPRWSGYVLLSVTSLINFLSIATLSKDDLERWGVDLVFGMMTFCFSTLVVLQDRSKLLCHGVFHKARKGFLEGVILMACLIWWSIGTAYQTNVNGIAYNANNIYYSAWASLLASGYLLNEWSSAKDILSVAELTGLSLTLPSWYTCWFFSIVVLFTSVDMLVYLEEQNLDDASFGIGLGFVSSVISAFFILVHYNFITSVEEGGWMELSSSFFLILLWTIGLALITQDRGIAATLSGTQCKFETASTNAVVILTDLLQLQREAEANDNELEDLEEDQVMDESLITTASFNCTISYNVWNADTTEMDMVLLPCSDVLAPARAAPKGVPGSNLYFAAWICFFSSLSVTFRWKAAQALQFAQAQQERQERQQQQKEQLQRQRDSAGFSDSDDGDEDDDEDQDTINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBQ4</accession>
    <name>A0AAD2GBQ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="586" mass="67225" checksum="5C210216AC109864" modified="2024-05-29" version="1">MTNYITTFVNQESLKSISFPKLPRMSAITQQQQEQPVQETIITGLVCAVAIVLLRYMVLDTYRTYQRLCRQWNRRQPPVSILRRPEGGSRKKNRSWFGVFIRKPNRVRFAKIFRRTFVPNKHELQSRRECWGLIQWRIQLHDEVLPEIENTVRFVPHTPVSILRPSRQDWGSPKPTSSIRVHFAPKTRRRNFLPDEQDLQSRRQLVRQIDRKIKRRNARRWKIDFKPTVLATIVEDPAEEDLSNTDSSLDTGFIDGKIDSEIIAIALENHRQMLPTVLHDMLSNFPVPMDLDDDDDNEPCMEEQAPLSLKRIATSCLISSRPTKRRKMNSSFTVPICAATWAKRTNELFTPLLPVIIEDPEEDGDESHIDSSLDAGFNDDIANEPSTRLAKADAIWVNKSEEILAEKANLNKMTKAERAKWANKARARRSKGQKEIDFEPTLLVIIEDPIKEEEEDEVDDVNEKKEFKPSLHVIIEDPEGEDLSTIDESPLDAALINDDFDSLEDGSDGEIFAAPTEQSDNARTTDIPSDGMGSGWTESGKRYSRRLQLKLSPEKKDPSTEALGSDMTKKGRRYSRRVVNRGKGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCB9</accession>
    <name>A0AAD2GCB9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002381">
        <property type="protein sequence ID" value="CAJ1968434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCB9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="106" mass="11942" checksum="DAED20D5C0885E69" modified="2024-05-29" version="1" fragment="single">AEPVFEALDKIFRRYNKAGFKVKTIKCNRAFIPLTDAMLDNMGVTIDLTAAGDHEPTAERNNRTLKERVRVALARLPYKVVPKVITECLGRQAVELLNAFPQKDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGC3</accession>
    <name>A0AAD2JGC3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35609">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35609:SF1">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="453" mass="50179" checksum="A00927D84D3DF473" modified="2024-05-29" version="1">MSTSHHSMGFFENAFGFNESNYSSTQKSLLDRATFSYTPPNPPTREYWQEHCSFHVPNGDKGMKQISAGTFSMPSVEQLRSRVQQELDFLLPKQQQGTSAGQAENNKTTTIQESQQAASKVTVRNMVGEARSLHSEPFSAILGKTSSNKYPPGDFPPQNHYIFQAASQFNLLEFPSPRVTPEAGIAGYINDRTQGPACAIACAAGTAYRNYLLPMMKDGDSGSTSSSKESTNPAIEQRGQTKEWQLNGLQLVEDYLKTFTSLQKVPWTVHNGYMEGQKRYIMELNALLESDPHLQDALTSRLQIGVQEDATVTDCCPVTTATTRTTATDHDDLFQVTQTYNSAISIGYSRLSSSLWRPMATIVLQATYEATLLVAILKAIQFALRGDPKQVTVLLTKVGGGVFQNDDCWICEAMKRAIGQVEELITSKPYGIGLDVRIVHFGEIQDEYMSLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI19</accession>
    <name>A0AAD2JI19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042081553" description="Right handed beta helix domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="40972" checksum="3D3C3C9E158C7213" modified="2024-05-29" version="1">MKMTGLHVLSVLLVAWSTLVSAQTDAPTSEPLPTEHPCVANLPDAPSCWSSLDDVWCSEWQVSQNQTMTRTYYLCPGEYIVGDPVSNDGAQPWFGGERGIFLTPNVEIICGDDGIASTDCTLTGGTFQLQATNGGEPGSNLVQGITFNQANTFTFAGGFAATQDLTFKDCAFLNNYNIFVWNIADDPDSILPITYTLEDVLFENNAVVVAGNQPGLVAMNNPAATLVLKNVIFRENSAAIEGNSVGFAVNSVGGLNMTDVCFLNNRWSVAPVISIGASTNASNIFSTEQEEALLCEFAAEVDTSNNLVCTIDNDSEICSVIGVTESPTMSPSIADSESPTTDEPTIAPVVAPTVPEEAPTPTGADSAAHGHTTMTILLASVIGLGLLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI40</accession>
    <name>A0AAD2JI40_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="212" mass="24387" checksum="857638C9768027A5" modified="2024-05-29" version="1">MKFFDKKRDLVTFQDGDQIAGVDDTEQGYLEEAFDQDYEPEDEDERDFNLRDDDYESDDNLGDEGNEEEEPPIVADLNHHQENVDRGTDDIGSLVNDLEDLQEPPEEEIVFEPERPQVVKVTRSGQTYAQAAMSGLNISQVPKKPREWPLSRSGISANKNKNRVATRRKHRERESKPLKNKLKSGIRTKVLKTVKLSLKHSTIYVSNRLGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJP7</accession>
    <name>A0AAD2JJP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001932">
        <property type="protein sequence ID" value="CAJ1957011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJP7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1957011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="137" mass="15279" checksum="93C9019DB6478D58" modified="2024-05-29" version="1">MVDAAQCIPKAGGSGIASNVIDVNVFDWENVHQSHTGTPIIDGYVTLDVGNEGLTIFLQLSSPSKVRVSQMNEEVKKLDFAIGRHRKWEPERQWILLWITNREVDIDSTADERLLWVDKGSLTGHCPLIGNRGLVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKB5</accession>
    <name>A0AAD2JKB5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKB5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041924037" evidence="1">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="238" mass="25276" checksum="B54D9E36B44AC2C1" modified="2024-05-29" version="1">MFVSATILLIALVGSASAADDSFNVKLKFLDDGITVGLDTGTFVPAADDNLVSSCEPLDIVSLCASFQCEKYDRSIDVFSDLISLEGLKDVSIETNAPYAIHIDDRNEVTLTVYGPNGSLDYFGFETFCTGYNGFESDPLCAQLPNVPDAIEQNFWNGGANPGAGNTGWGSCIKCSDFCHVATEFYGDSSCIGLCNAYDWGDFVLPGIQESAGTNAKNGMAAWLLGLSLTSLALFVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKT9</accession>
    <name>A0AAD2JKT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKT9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="68785" checksum="2AB9F3616DFC4E41" modified="2024-05-29" version="1">MAAVKRLNARKGICNTNPKYSVDSSAPKMRAPQAANAGPPLPQLYVDTITRAFGEDADLHRDVLRIAPDAMPIEQRIAYFKRGREIMKQAGSAITAPRDLPPTIRARLKAINMAYDIISNPEWHRQYVTRNEQSPRIKSGVRFNDHIQEHVYELDPAEREYMRERRERRMQRLKELEADALSNESFWNDLLADMENFELGLGGFLQAFPDQIAGQELQEALTDDSSFPDTQSFSSWLSSSVKKGGSLVDDDIETSSYMSSFNPFAEETPRSSSKSSSRGNVRSPTSLPQELAETNRVPRGAGKKETRNSNPFRDEVPDSSSTFNNDDDTTSLFSDGPLDISPVTSPFDDEDDDDDATNPFEDGALDITNDDAPDDVSNPFSAAASDSRFSIGTFQKMQKERRAQRASTRSSNSQISQDLKGAFDNPRASAALDNDDGRLTQRQSKNPFDDEENDVSGDQTSVFDGLDEVWDDEQGVHVDGESVISDLSESVVAKRAKQKQQAFQPFAMDTVKEDTPGSSNLNKDASAENPSWGGSENEQVGFTAAASAIAACCANIVADCQKNTEAMANLEMKNFTTIDFPSMFTAEQSKKPELEQDPFDEMEELFKEMGDELNDELGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL72</accession>
    <name>A0AAD2JL72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL72"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206">
        <property type="entry name" value="DEP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206:SF4">
        <property type="entry name" value="PROTEIN LET-99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="222"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="338"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="556" mass="62738" checksum="B047178C7EA2F730" modified="2024-05-29" version="1">MLKMKTDGPPKMRERSLSIDNESCSEAPLHVTSSLVVEKCQDQTPIKPARRSWKMTGDGGYETCETETEHSSQFLFISDDDDDSVADYRTVVSDITEPSAFGYLDDSSRRLHVESSWRQESIDTSFRIEALGPLQEDTDESSSPMPLIRPLSSAEGRSFFKTATKDMPPQPAVRNYSTSFGSFGDLPLEHNENAPSTVAETSSSYQPAKQAPSGLPKMAETFISGCAVGTHMFHLKKYPKTFVGNEAVDFMLSAGLACTREDAVFLGQRFSNELNLFHHVCWDHTFKDGRFFYRFNDQLPKDVRNRTPLSREDLCTTSAKFVAGMPVSKHTGRPFKIYPNTFLGEEAVNYMLNSKVAKNRPDAILLGQRMMEELDIFQPVAHSSRFKDSSHVYRFVSDNAIDDSLSSLVETVYAEQHTPASPVPTTTKPTRCTVNRKQPNMRVSFGFVQSRHFERRLDYNPATTSGPSLSLGWRFYDDLPIPLNELGTEASKLRGGRLSIQDRSSILGEWGYTTVDMSRATRLNKKVRQRRKRSLNKDRAAYVKTNVVPSPRMSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLA5</accession>
    <name>A0AAD2JLA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="13">TC-AMP synthase</shortName>
            <ecNumber evidence="3 13">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS18969</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 13"/>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000009">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041899848" description="Threonylcarbamoyl-AMP synthase" evidence="15">
        <location>
            <begin position="30"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="73"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1960959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="436" mass="47542" checksum="7EEC76E6CC2BF011" modified="2024-05-29" version="1">MSAGNQNLLFRLMLYITLSHLRRIPSCTAFQTSFQPTRQSVSRLFASASEGTRFTTMTTANKSEKVKAKLVSVDSLEECGERLRQGGLVAFPTETVYGLGCNALDQDAIMKVFKAKERPLTDPLITHVTKHSDAYELWNAEESSIEGKALRQLCDKFWPGPFTLVAKAAPHVPQTLMANTGFVACRAPQHPISIALIDAAKVPIAAPSANKFGHVSPTRASHVWDDLHAEDVWIIDTTESDSEVCAVGVESSVVKMELSENSEKGTITLLRQGAVSASAIQGCLEEAGIADNFDVISRTKKAVDETVAEVAPGQNIRHYSPNIVSRIISQSCYTSNKDPTHEEVEVLSKTVLIDFGGKLSSWEKHAIAYRDLSKSENSAEATKSVFDILRWAEQVDDATQILFPEIPDGPSVDALTLALKDRLTRAASGVVISRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMA2</accession>
    <name>A0AAD2JMA2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMA2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="86" mass="9901" checksum="7513282F856A16D0" modified="2024-05-29" version="1">MTVAEEKTHPVTESAIIDFVRACNEIGKAMPDATAEPMLWFVQPEDSLDYTRFVNLQPLETHRELSSYEDDSSSRRVQMPTNKREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMV4</accession>
    <name>A0AAD2JMV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMV4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF34">
        <property type="entry name" value="ABC1 ATYPICAL KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="145"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="392"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="589" mass="66886" checksum="D6C8B457111671E4" modified="2024-05-29" version="1">MVRIRRQLVPKVLGGIVGTAGIGGGLLYWYEDEGTRRAMKAYSTFVPVVLHYRWVEARHKYLATAKSSLSSLLSSEESTPNILLKKKELDQQEKEEEWKALDDLYADRTVERLGELQGMYCKYGQTAAGFTNTLGEAWIRALRTLENEVPPRPVEVVHQTILEETGKPYDETFVSIDPKPLGSASIGQVHRGTLMKDGKLIEVAIKIQYPEAQKLFSDDIHAIRAFCEAFAPEHVVMLNAMEQSNRGELDYTQEAKNLEEIRANLEKDGFAPGQVVVPRPFPELSTKRMLVMELLPGEKLIDGMRKFYAEWAEANGTTLEALENEARSRIEKEGIPAKYDGPSGWQIAIYSRYLKIRDSFVNVGIAAYNSVAGKALGASTISYQKSSIPPNTPRIIDTLMRVHGYQLLQDGVFNSDPHGGNFLLLPDGRIGLIDYGATKRLIRNERLSMCLLYAAIHRRDEEKLFQLCDIGGYKSKYGRRDILMKLILFGYDSWGKDVTEGKNIQQFIDDMKAEDPWEEVPDNFVMAQFMSTRLRSLALGMNSPIKCSEWWGPIAEEVLIKEGHPYESWDLEKMKKYQPELNMQRYKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN40</accession>
    <name>A0AAD2JN40_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="257" mass="28597" checksum="D7B3CDF62B6546FE" modified="2024-05-29" version="1">MPKKTIGFFVLLAAIASSLIVNAFQFPLDSATGAKFDVSLRLANSESATPGALRRRDAIFSIASFPLVWLLPQVALSKDESMVPTEYQAVWFDPKLPNGYRVLFGGNQKATLLLRNEPSDDEIELPVKVVEGKEMKLIFDFSPIGGQSNLEGTFTKNREGSRIISFPDKNAWINKKFEGPIGVFKDSTDSNRVIIIRQVKGPECVVQLRDENKITTFPGKAGTSFTFNFPDKGKVSAAFDMQRRSITFEDGTIWTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP26</accession>
    <name>A0AAD2JP26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1967972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="376" mass="40935" checksum="01D89AAED647BC1C" modified="2024-05-29" version="1">MSPKCPDRLLPKIQWKHPDEYVDYGKKLNLNQIGATLPATVPAIVPGASASTSGASSVAGSVNTPLRLAGTTGNQMMQVPLGMQLMQIPTQGGGTLTVPYSMNANGEIAFSGMQLGHQGFSVAQVRQGFDATQAQTPQVVKTGYYDTSNVFHNAIKGKDENGNDVYLIPCPAGTTNVELQAGWYYAGEDEDLPDLPTEADLGLQFIQSCRRERDPFGLYNHVIMDSGCTNTTICNGELMHGLRHAEKELDLHTNVGSRVLDEEGFPPPVYHNEDGIANVLAMREMIAAGYRITMDTDADNAFIVHCDGDRKMQFVNRKGVYVLEQLGANVEPAAKETSAMYRRQLSNLNNQPNFELSSNKQNGYAGLRMTPKMATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPX7</accession>
    <name>A0AAD2JPX7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002402">
        <property type="protein sequence ID" value="CAJ1968702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPX7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9386" checksum="6A65FC0294EE4664" modified="2024-05-29" version="1">MYFAMAIDDLHAQHAMHDFYSTNAGGGNHNGNGNGNGNNNGGVPKLVSESTQQWMLILLVVVSFALMGYVFTLVQEQERKEQKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX17</accession>
    <name>A0AAD2PX17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS20283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="112"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="323"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1963701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="415" mass="47031" checksum="23F1DAF6175D222E" modified="2024-05-29" version="1">MASNQDSTSVYKDLIQFLQAPRMDLKMEATKAVLQVVSDRDEVLRLVEHGALLPLLRIASDASDPTCAENALQALLYLSSSTDQATNQCIDELLQNKAVPRLVELVLGSTRSQHKQVNFALGLLANLTRTEQGALELVGKTLPDYAVKEVDEKEMENRSRPTMELLLDRYFNLQYIIDVVDYAALEPYEWDTLDKDPYQHFAAILMNATQVKAGRQFVMRIPKQKDDEPAQSVLERLLPQLQTSNPIRRRGISGMVRNVCLEIDAAWWLLNQLKLTSHILYPLAGPEELDLDEKTGMDPDLWLQGPDKAREVDTTTRLHLVEAILLLCATGRRSRETLRLARTYVILKYCDMTEEDEPVSERINECVQYLRRDEEGTEEGSSDNMVEEATRKRLQLTMASTQVGSKSAADYDDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY41</accession>
    <name>A0AAD2PY41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002441">
        <property type="protein sequence ID" value="CAJ1969970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1969970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="78" mass="8599" checksum="91412AFE29830A43" modified="2024-05-29" version="1" fragment="single">ILQYWRLPTLYLLLELVTKSKPGNAAASYLLENTDAAHAMALNRQATMIVSLSGLQAYTTNVLIAELTKVFTSMAQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAQ0</accession>
    <name>A0AAD2CAQ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-glutamate cyclase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1908572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.20">
        <property type="entry name" value="TON_0340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025504">
        <property type="entry name" value="GLUCM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022:SF10">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14336">
        <property type="entry name" value="GLUCM-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042242056" description="D-glutamate cyclase-like C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="D-glutamate cyclase-like C-terminal" evidence="3">
        <location>
            <begin position="784"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1908572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1086" mass="114290" checksum="FDD37D5D8F4186FC" modified="2024-05-29" version="1">MMRKTITIVTAFVVALVLLVVLLSSDAPTESEPGSYLRNGGGKEPSSQNLQTIAPSAANPIEFPSEEVKDSIDLPLGDVNEEYGSPKDGLNDTAGVSSPDDESPKLKIVVYETSKLSTSLETLLFVAERYGVDTTIVGQGTTFSGFGSKYAQLKETLDELNKDKNSIIALIDGRDVLLNVASQVSYDAFHAQIQQFVSTFNELTEGKPDAVLISGEQQCCVSALCYANSPDYYFDSVTGERKNRACPSGEEGCMWMDNDSVRYWESTMVSEARARSGSNNFSPYLNAGMMVGTPQNLINLIRRLDLGEEEDDQAVLSAMYIQFPDLIVLDYQQQLLGNNAWPRGLEHGCIFDFDPNSKDLAYLTNKETGTAPLLLHTPGKFYACLDILIDRLGGISDHRYAQIQSRSSSNYGTGNYGNYGNYGNYGNYGNYGGNYGPSNYGNYGNSNYGNYGGSSSNYGNYGNYGNANYGNYGSSNYGNYGNANYGISSGNSNYGNANYGNSGSSNYGGFNYGSSNYGSANYGSSSGGNSNYGGFNYGSSNYGSANDGSSSGGKSNYGGFNYGNANYGSLSGNSNYGGFNYGNANYGISTTGPTAAPTESPTSVPTNVPTAAPTESPTSVPTNVPTAAPTESPTSVPTNVPTAYPTSGPTSIPTTHPSQAPSPSPTSLEERCEGSPFKACCLAGNEICCDVCTAEVPGPAPTKKPTSIPTSMPTSNPTGEPSIEISAAPTEAQVEFGGLADEVPSSSPTSDCSEYFSPRSAFTTTNNRPFAMSPETLSKTCSSLQDVIGTDAGNRGMKCLIVPGDLEKAANAIASLEPKSTVVVLSGFPCCVSHDPPTETDGPPGTFAIARAMAALGHEVIVVTDTCNEAVFAAALKNLALPSEDCGSVVLHAYPPSLSEEEEKKFSELANDCSLLVACERAGPSKDGVCYTMRAIDMNEKGLIAPLHRLVKESNAPFIGIGDGGNELGMGKVIDQIAANIPKGATIGCVVPADYLIAASVSNWGGYVLAAVAAVTKANDSKSLEAWLERCLPSEDDEIALLNRCVAVGCRDGVSGQVEATVDGMPLETSMQCLRDIRKSALDAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAW7</accession>
    <name>A0AAD2CAW7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1913301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAW7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1913301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="95" mass="10286" checksum="84FF713D2FEA1619" modified="2024-05-29" version="1">MAQARSSGSRLVVGAVAGTLGVVGLSTIYLPFFADRDTIRGLHEEEAPPTSHMLAQEIRKLQQEGILRGDDEDEAKPPEAKKAKAPGSMWSNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBE6</accession>
    <name>A0AAD2CBE6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1905157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBE6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042283326" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1905157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53094" checksum="9694A0392C764711" modified="2024-05-29" version="1">MTILRLYLLLLPLVGSSVPESHVRRRDIGLRFSVAKKKVDVAGPDPTCHQQDVDEILASCDCAADFDGVAWKNENDYMSCLIVHKTFTPCGLQRIIESSPCLPFPTPQPTTSSMPSTSMPSSVPSSSPSMIPSTSMLPSSSSIPSSIPSQSLAPSVEPSTQEPSSVPSHSIAPSSDPSYVPSDLPSLVPSELRKPSASPSASPSLVPSGSSGPSAQESASPSQISLGLLNTTRVGTADQYTLDDFLEEDDATKPFLEIVGDNQWPPEVFPLSMCQGDCDGDKDCKGDLQCMPRDDFEPVPGCQGAGEKAKDYCADPKPPRPWSGWDAFYKFKLRLFYDPLYFWQEAFEESWWCMECTRCSNYTLGDGDEANCTIPGPNTTSCMENDNIWIMGCKRDNRDYQYNIVKNVGSGDQIRVDSTHLCFSTLNTTFLELKTCNNTDYKQLWMPITNLSKFVLQPYEDHLPHFNNSLCLTQMHHPKSEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBF9</accession>
    <name>A0AAD2CBF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Agenet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS83</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1891926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1891926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40091" checksum="623C9335ECB880D3" modified="2024-05-29" version="1">MGILSNPRFPPSPAELYARALWDPKPTKSLKTERQLAYALGYPSHWRVVRTVVRKDGKHVIRDTIHTRFGKTSKQQCNYTWFNHEAAQKAARELEKEGTMSGSHLLPALPLYTKGDVVEVFWEGKWYSASITKRKKQADSFFYSVVYHQDSATQDEVGEEDIRPGEDPSTLAVELGFTADWKASRKGSRYILTAPTGERFTTKKAAMVFFNEIGPQMAEEQDVGDPPWRIEGHEWIGRSVKWTSSHKISSRRTVDVEQEGRITGYIKKTDVDKEGSPGFISEATGEPADLFHVVFPEDKNHPYSSHLLTSQDLEEYEVLENLLEVEEEEPAKRKMEEIPTSSTKKKKRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCD2</accession>
    <name>A0AAD2CCD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Photosystem II CP47 reaction center protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS1478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000047">
        <property type="protein sequence ID" value="CAJ1928475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCD2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009521">
        <property type="term" value="C:photosystem"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009767">
        <property type="term" value="P:photosynthetic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.680.10">
        <property type="entry name" value="Photosystem II CP47 reaction center protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000932">
        <property type="entry name" value="PS_antenna-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036001">
        <property type="entry name" value="PS_II_antenna-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00421">
        <property type="entry name" value="PSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161077">
        <property type="entry name" value="Photosystem II antenna protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="6" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1928475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31144" checksum="60A3E7056CE629F6" modified="2024-05-29" version="1">MGNIETVLSSSIAAVFFAAFVTSGTMWYGAAATPIELFGPTRYQWDSGYFQQEIERQVEVSVSEGLSESQAWSRIPDKLAFYDYIGNNPAKGGLFRAGPMDKGDGIAEAWLGHPIFRDKEGRELTVRRMPAFFETFPVILVDKDGIIRADIPFRRAESKYSIEQVGVTVDFYGGKLNGQTFKDAPTVKKFARKAQLGEVFEFDRTSLESDGVFRSSPRGWYTFGHANFALLFFFGHLWHGGRTIFRDVFTGIGAEVTEQVEFGAFQKLGDKSTKKQGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDX4</accession>
    <name>A0AAD2CDX4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="207" mass="22957" checksum="57929CC2CA5F99F7" modified="2024-05-29" version="1">MMEVNSSPISELSTPLLGTTQQEEGVQTKSIPNSEEETETSSQFRFHNPRWLCYQRIVLGLSLPPLYFLAVEMTKEHCYFCHRAIDDSSNTCIVVAAALWGSLMATLYEQCNRNHHCCASVFGGALAASGSLYTMWMLLESIASNDVVFLFALLVGVLGAMPGILLYFVAKIFCSEFSKQTNVGNEATRERVMSADTVTEVEEEMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEP2</accession>
    <name>A0AAD2CEP2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS2835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044632">
        <property type="entry name" value="DNAJC25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44176">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44176:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042156276" description="J domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="66"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1932436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="390" mass="45390" checksum="505ABCFACAC2F07C" modified="2024-05-29" version="1">MLHRTALRLALCLLFFVSVSAEGDETTPPAEDVKKPEPPEDKFDAEGHTDWGSYYDPQNIFCGKFDCYKILGFDYGEWATDRRPSTKQITKRYRALSRAWHPDKSKHKDAKERFVKIARAYEVLTDFEQRKEYDLMRFNQEAYFNKYGSGVIFAYAPKSDVTIIVIFLLGLVNLYTWFAQKNRWQNVANRLIKAAVEDWSPSMGGTPESKGLRVDALAILKEKEDTANNATAETEKKGGKAKKIKISAKEKKLMEQEALRPIITEMVENIEDFGAGFHKPTWEDLFIVSLAKFPAKFASGLHWQAKYWYRRLMKEELNEEERAVLTERAVGHVHWELASDEDRKAMIKLELWVKDNFIEWTEEQEFKKLSKAEQKMYKKMKRGGSKDHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEQ7</accession>
    <name>A0AAD2CEQ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="359" mass="41517" checksum="CFFA418FB2E9E174" modified="2024-05-29" version="1">MAGTRLWISVIILAELIILALLSLYYGLCVQNDDVLCHALDDQKSNPGALRPLPRPSWWSTTLHIHLVMEESSEQSLHQWSQRLEEWMDTCKLEDLPYFGSTQIHMKVVPRSNKLWEMVEGESVKLLKNSSIWNYLPDRQFDGVSAAYDKDLDWMLYLPAEQEKLSDDEIPSWLAWKQGSEQLVTVFTYHSNDEFEIMTSLTSLIGSWLEKSASDSESVPDDEMAENDYLRNLQFTWQKAIMQDFDDWKMHLTPDERSEVFLTLGKTSHSFSTRLQSLLQARAILEGAMGRNKDTMTPEFPLEHYAAVFLPLLFPLLLPLFTSFVKELKRFKEKVKTKREKGKDSMQVKVVDGEGPKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF80</accession>
    <name>A0AAD2CF80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">High light inducible protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF80"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042294947" description="High light inducible protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18296" checksum="5C80647E5AA388A6" modified="2024-05-29" version="1">MYSRTLLLALLTAIHCEAFVVPQSMSRPALALREAEDDEDGTEMNPDNPNLPALKGDFDWDEKFGGDDDWITENVPGKVVLGELELAEQSKALAALESNWRKEREIKEFEESRKTGWTGLAELANGRFAMFFLVTGLLTELWTGVSIPGQVEEMLRIGGFIGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGG4</accession>
    <name>A0AAD2CGG4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000212">
        <property type="protein sequence ID" value="CAJ1932153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGG4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="162" mass="17625" checksum="0B2EEE47CB7DE33D" modified="2024-05-29" version="1">MERRILVLKNLRHGLLVPLKIKKCGDGMSEHAKVTKFLSMIKEGPQGAGLDACKTLVRGSQACMQHLRMAINTLQTENTTQQTHRLTAISGTRALAAVDGGGRNSNCGRGRGRGRDRDNGGCDRGGRNRNCNRNQHGRGGGRGRGGSRDHDGNVWSHFRDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGL4</accession>
    <name>A0AAD2CGL4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="347" mass="39381" checksum="FDFC0CA65C6EF1AC" modified="2024-05-29" version="1">MNSDDETLQSKDSNTGPEVDLDILPATAEEVFNLDPYSCWEGTIRTVLSGTRDKDSPLKILREHESTLVRFIRSYLTNEFASHLTLTFPSILVEEKDEDILARIESFQEYWRGYPNEYDAGGVAFMRLSSIEFPPPADRNVNMLPFIFGSQDSLPRDLQCYYPLVAKCPFNKDEIGQVGYLTVHESFVDATKAQRREGLHIETPGIFRSAKRAAKFIPGQETSWGWGRYSPNRYDGGICMASSVSNTSKVWDALVDKKCPNIVDKHGGCEHLRSLIGKGTKLKAGELIWMTDCTPHEALCQETSGYRQFFRVVSSYVSHWYEDHSTRNPKVDLPARVKVIKGNKFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGN8</accession>
    <name>A0AAD2CGN8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000102">
        <property type="protein sequence ID" value="CAJ1929905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGN8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="548" mass="62942" checksum="B503A34BC525678C" modified="2024-05-29" version="1">MRTFIEKCTLSANWKPKSKTESDPLHLPQYLKETYSKKYPFFSLVFGQKPKPAAWDIDMKMFLFAIAALTTQRPEINRDFFLEIVAGCSRSQHKVLHPDILLRAVNPENLLEAIANIELIDDSAKGSGELLIEAKIDDTLPKAIPNLIPVIDSDSGDSWIKTNIPRLADEPLYKVDNSSEETMHQEDELVMEILYKRLAMDKSDRSYEMNRLFHCIANRTLEESRVRTTVSEESTTSQYISKVSFRSPRNQMIEKYYALLPQPKVDFTALTQNAKKKKANLMKEIIAQLVGPDLAQQEAFLKLSFKKFKDLILFHEEDFKWNEMHIALILCIVGSANKVIMLDRLERLLLGNTRFPPQLKVFLSKLGWKWRMRIEAEMIPLEMNGNKEVRPQLSWHLATPLRALERQVEAAFLSGNFLHSGDFSLMEDIIAVVFGADKDEIATSMLIRILNRVKGNCSAFVTTLAMYEHAAECHENMKKTFLKKGSPIQRFLQLLLDNKFFALTVNSIDKDEGHVVQSQCIAINLFADHRQSATDERMLPQMKVKVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGX3</accession>
    <name>A0AAD2CGX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS2823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="4">
        <location>
            <begin position="206"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1932412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="284" mass="32425" checksum="77758E23CC98C792" modified="2024-05-29" version="1">MIFGPSFQTTRPWDKQEEKEDPTPLPPDDERCNDLKNHLRSLLDRYDGSTKHEDVIDAIGRLSTLSPYTEHSPVWLDLFMGEFFAQTSPNFPGRLPPAHEGDTRVQYTLGKLSFNTFHPSDLVCTLLGVRNVIAPKSDGTFTYDLICDIIIHHEDGDIEAQICNESYCCKDDDESNRVHVFFTGSKLSPAPAVIENEVKMSQWSNTFNEATLKTAAAERTYFGWFLHQLLKRMLGMNVRVGESNSFHLTFKKPFQGHIDVLYLDEEMRITKGNRGTLVVVERLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHX7</accession>
    <name>A0AAD2CHX7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000406">
        <property type="protein sequence ID" value="CAJ1934885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHX7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="178" mass="19888" checksum="3A10D7AFF4E4A0B3" modified="2024-05-29" version="1" fragment="single">EIFGDIQDGNQIAGVDDTGQGYLEEAFDQDYEPEDEDEHDFNLRGQFDDLDDSKRAELLADADNDVDDVPELTVRFLGDYDYESDDNNSGDEGNEEVELVVADLDHHQENVNRGTNDTGSLVTDLEDLQEPPEEEIVFEPETPQVAKNKLKSGICTKEIKAKRFGDDGKGAVDRVRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIT5</accession>
    <name>A0AAD2CIT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIT5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="84"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="213" mass="22818" checksum="1073245B46D467CD" modified="2024-05-29" version="1">MVVVKAAATKQAGAKYGIAFSRKTPDSPLMIRTIRDESPFAGKGLEPGMIVTKVNGEEMTWLGPRDAAKVLQKAQVGATMQVEAATLFKAAGKKPKRKTKCGIWLKNSTKVPGLFISQINGDSIFAGSSLETGMKVIQLNGTSCHDDMKFHEALELLKKASGQVEIVAADTPYKGKMKGASGGIPGLSPLSDSEDELDRKPLLDRLFPMLVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ12</accession>
    <name>A0AAD2CJ12_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ12"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.780">
        <property type="entry name" value="von Hippel-Lindau disease tumour suppressor, beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037140">
        <property type="entry name" value="VHL_beta_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF8">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042171497" description="NADP-dependent oxidoreductase domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="454" mass="51618" checksum="99C3DFF425B6E0D3" modified="2024-05-29" version="1">MNRKPSFLGRSVFTILSTWSLFHNAIVSADLPTTKLSNGIDFPLVGLGVGNLQHELIESQISHGLSTKMNYRMLDTAHASHNENIIHTGIEQGLSSYAASLQDSTDGANSTVHVITKVWYTHLGYERTKISVKESLEQLNSPNISVHLLIHWPRCRDDVPWMDCEAEENLLPQYVKDAGPPPHLDKDHAYLESWRALEDIYMGKVKLGTDLPLITSIGISNFDLPEIKELIVHSRIVPHMMQGNSWSYVFDPDLIYFLYRRKIHFQVYNVMNGIYERSGETPLAFRALGDIARALSAFAKTEHGRDIRYTEAQILLKWFTQNKVSVIPRTRSLDHLEENSPEAVGSMPHLTPEEEEQVSAIVRSMFEGHDFDQPQASFINAASEKVHLFWKDLDGMEHPVRTDLEDGDVFDTATHTGHVFVAYDDSQLKRKEFQVTATYNQVEEIHIGELLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ14</accession>
    <name>A0AAD2CJ14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042046773" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28260" checksum="BB2C33F4484D9DDC" modified="2024-05-29" version="1">MMKPSLGILLVHALCLASALVTGPSSVLRHVRRNPFDSCSIGNRYSSHNDHTISRTTPQTSFAISPESADYQESIKGNFTAVVATTDKQNKGFINNSNITSLVTGINALQACTAGLCLVGRLPVLNGVLSFLVGKGVLLIGIAVMALAWNETRNPVVDKDDSRLLTTTGLYSQIRHPFLAGQWMALIGFAGCFGKKQSPIRYLFASLYYLVLRKKVELQEQELEQQFGHEYQVYKVLVKGQLIPHAISSKFFPTLSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK66</accession>
    <name>A0AAD2CK66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1894649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK66"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042177112" description="Circumsporozoite protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1894649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="395" mass="42052" checksum="78876F733E0E360F" modified="2024-05-29" version="1">MKIFNIITVTMLFFQAPVILAAEEEAEDRQHFQHPDEEDVPEIDITAHPTDMPSEVPTTFPTPAPSTVPSANPSQSPSAYPSSSPSAKPSSTPSNAPSSSPSFAPSNEPSTKPSIAASFAPSDMPSQMPSYIPTSSPSASPSDNPSFVPSDMPSTVPSVVPTKADCESNDGSFGEFPNEDAIVKYSYEVELISILDADAVESDVLPLLENGIVNSILPSLFADSCGHSLTTRNLRVQRRLSEVKGISKYPEDLVYDDVACASVEDGNSCFVVSGELTIFADDEDTLDTETENVKKAIENEMTAGNLNDAQEDIVRVSYVDIDPTLNNIEDTPPGLNDDDGKILTISPVPFIIGGAVLLAVLVGIAYRQHKKNSGPDMDESQIGGSQVPGNTETDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLP1</accession>
    <name>A0AAD2CLP1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000724">
        <property type="protein sequence ID" value="CAJ1938475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="496" mass="57338" checksum="A98864F788D84958" modified="2024-05-29" version="1">MLEAQVQWRRIPGQHESLEGLIGKAGNKPNAGEEEQGADTDDADPSLAAKAEFKRWVKKTLESLDIIGHQYGACLGRQSDRKKPRTKFNNSLFDKTKKCGHEQAGVCLCLYLAMISDRGRFIMLLERTMYPTFYKDQVGAFELVLTMEQWLKKKKYPARHALNPEGLGKVFDYYTDWIRETTFRKGMGALLIKNHLMLHVPLYMLHWGPPRGWDSGPSERAHKTEQKQPAQRTQRRQHSFVKQLTARLEPRAIEGWRSFPWWCQVFSRVQQNRLDGSKTEGNYLQEVINLVCEKLLPLADSDKIEGFSEVKKTIDSEPICFRAHPNYRSKSRQVTDTWHDWAKFVVPHHGDAHIPGQILMFIRMPFTNDEVIHNGIRLQSKQVHAVVNLFVDQPQPPFPNFDTPIVKWGKTEDTNFYIIPCNCLVAPAIVVPNLLEQQPQGNVANANARRTYKKRRFKLMQEPGNEPLGDGYFVVDNQEQMAQRMEELIDDIMKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CME9</accession>
    <name>A0AAD2CME9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CME9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF95">
        <property type="entry name" value="CYTOCHROME B5 TYPE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="90"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="191"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1939053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="287" mass="30580" checksum="4E3C753E1E55D991" modified="2024-05-29" version="1">MAIAPHTGHPNDLEAPSTNEHGAPRKMFRNREFEDDVGDSQRRKRQTRSRLSACILGVVTLAAVAFAAYYFLIKDGIDLQKGNYQHKNFQGSVAMSAIEMHATTGDCWLAIHSNVYDMTDYAPLHPGPDSLITDHCGTDATAAYTSMHSQALLPTVSEYLLGALQGADDGSATPPNSSNESPSSGGSTAEGSQIALATMQMHGTAGDCWLAYYGIVYDMTQYAPNHPASSSLITNHCGTDATNAYASAHSRSLLTTVARYRLGALEGTDTSAFPPATNNPPSDSSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMI2</accession>
    <name>A0AAD2CMI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000058">
        <property type="protein sequence ID" value="CAJ1928710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="422" mass="48623" checksum="037583CF58BC38DF" modified="2024-05-29" version="1">MGHPEVQVNVHNFFLIKQIVEEDGRLIAVGTFIQHCFEDEKTKEMIRGRMHKEGKNIDDYEIKFEYRFNDETADNDSGYVRHRRTEKYETDMGTLYRHTYQVKAPLDVNVELDYFPFRVVSAKLLVELSTFTTLDNETRLRPNLILHLLDKTNMFSIQKDQMTETKGSDFDQAKDKMDKADSYDFISPFPKVAYLYDTKKRYCPKFMVTFLMVEDGMKKFVEIVAPMVLIAGMNTIHVLNPDEGVEVADYIANSATFALSVLVFLPTMVGTSRVQQLWTANNLYIVLIFVALTLSSIPDTWAGHKGYAVAGMIIYWVSFLFPIVNSVRYLLFLRKAKRKANAKHFWQGPNKKAYKASKKEVAHEFAKVEEIVYKPDDERMQMEYTLREVHKFRVLEFASVGAIARSKKKITTAGAATPEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMM7</accession>
    <name>A0AAD2CMM7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMM7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1937938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="445" mass="50343" checksum="959C4638D65904DE" modified="2024-05-29" version="1">MAISEDAPLSPEEAATCREKAREVLSRLDQTTDPKSSCWVRHNTNTANNTNTNIRNHDDDDGDDDDECKEKSKDAKYFDTHGFLVVPQFASEEIVRDLKEQMKSLVKEHWHPFDKNTNTNGDDDDDDDGPTKKNKKIETFGTDAKANEARGDYFLDSSNRVHYFAEQKANLLLDNQVVVVVDDATNINGDDDDDDGETLITERKISILNKAGHGMHNIPGAFQDYTLSDKMRNLVLDLGWKDPVVPQSMYIFKQAKIGGTVHSHQDSTFLYTTPRQTCLGLWLALDDATLENGCLWARPGSHKEPLRRQFIRNPEYFEQLVEANNKQVPKGKDDVPQLKFLQHDENPKVHWDGGLPTTSLLEEGFIPIEVKAGDLVTFCGTLDHLSLPNFSDLPRHTFQLHLVEGPKEGITWSPQNWLQYPEGAKFIQLVQDNDDGGDDENKPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPE4</accession>
    <name>A0AAD2CPE4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000768">
        <property type="protein sequence ID" value="CAJ1938790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPE4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="196" mass="20878" checksum="6E35B3A82F7DF8A9" modified="2024-05-29" version="1">MSADKKVIYQSYRPTYKLTFQLYAKGMVARLGDHTCPSVALLDRHVRFLDSALAKTFLDAKNDFQRRKLSLAGLANLTLWLGWLQSSECFGLNWEDCSLVEPADHAVSTNNATMETLFSGHMTALLATPLKAAFGPFTATAAGAAPTSHAATYAAAPVSRLPPKPLSMNTAAGVYAAPTKMSPPPTTNGSPVSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQI5</accession>
    <name>A0AAD2CQI5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011735">
        <property type="entry name" value="WlaTC/HtrL_glycosyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="415" mass="48278" checksum="5287328736AE6ED4" modified="2024-05-29" version="1">MRIQTKLSRKSQKESKPLSIIIYTVVAILFVVVVWLNIVVTKAGKSSLLENDNLKPPPKPEKLEDRKGGAIIEDASLNDGEPTIKTPNGSVLPSAKALLSRPPPYGDSQVRFFSDTMIDSPNTVVTAYHRVPSKFHAGKYDEWMKNILSLQDAMVIFTSDDMVDQVKNMRQHALDRTVIVTLELNDLPYGTLYPTKFWEDQLKRDPEKRIHRSYQLFWIWLSKSWFVNEAIRLNVFQSDLFMYSDIGCFRMKRYNSKTMIQHREVVPPNEMLQMAHHKPNPPKEDLFNDKYRHFENFYHSGSQSVAYKDTWIKFHEYFLDTIDRFLEKDMILVEDQAILQSVCLSHPEICVYIPFTEVRDNHYFGLRYLVHYGGKFNFWSFNAGSPLIMLDLANAVEQFGHVQSVYSSIDFPESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR23</accession>
    <name>A0AAD2CR23_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR23"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1934138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="92" mass="9985" checksum="03B12BB26C7EEEEC" modified="2024-05-29" version="1">MAKQLDDQTTRLLFAASRGDTRTISLMCSQGFDADNADYDDRTALMVAAMKGNTDVVRLLLEYNANPNLVDMHGSTALLEAVKNGNSCGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSK6</accession>
    <name>A0AAD2CSK6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001258">
        <property type="protein sequence ID" value="CAJ1944835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="269" mass="31519" checksum="ACD374A8275658DF" modified="2024-05-29" version="1">MLDNYSVAVQNFDIGIDDVRLVNKDIHPRFCDSLNLLHLFEDGFLSQVNHVRLEPLLPPMRHPSFCEHHRKYSLNIDYLVHDFASICHSMKRTSRTIFLDLGASLQYHNSRKRRANPTLLLVDVYNRFGIKFDHYYAFERTELSSNEVFKSIPAHLLPSYHWFNVGVKSDPLSQYNPLNSILKAMKEDDFIVIKIDIDTPAIELPLAHQLLKEPFSKLVDQFYFEHHVRMKGLLYYWRNTAMGTLEDSLDLFTSLRQSGIAAHSWYFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CST5</accession>
    <name>A0AAD2CST5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CST5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041972617" description="Plastid lipid-associated protein/fibrillin conserved domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27733" checksum="69C9FBCFB0EA0A2D" modified="2024-05-29" version="1">MNTLHSRRSVLGVVIGSMLLPSVVSSSPAFAEDAANGTTPTFVSTGAAAARENLLSAIQQGKPDAEVLAAIDRLKPFNPLPPTSSTAAKSLEGEWRLLWSINDDFSPLLRLPKPFKPNSFQYFGPIAAAEVGEGRVAQGLTSGLLGNSQLWLSSGTEPLPYKTVESGNAPYRLEIEPPFRFQLGGRLGTNQPKRMIVEAGNDADFRKVNARTKEAQLAGKNVYEQIYVESKGKGSLRISTITEGDPAIIGTILIHEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2024-10-02" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSV4</accession>
    <name>A0AAD2CSV4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001225">
        <property type="protein sequence ID" value="CAJ1944663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1297" mass="148333" checksum="1050654F31304F2D" modified="2024-05-29" version="1">MSATNLRCVNCKRTGDDVRVKQYSRVLLRGRHRKTYNCVPKLTTEENIILRVHGQDALKVWLCSCCDHYLLGGSNDPADYWPAMVYKFLVHENSEHSINVSVYEKWQLIPSTWRPWWRSHFAMYNFDETEKSLFVDFTEELEEVKEAIDDLGWVRLTKQMDKHFAYPEIRCPFGCSEFLHKTNHVPLKDFLWCYSNYEMQCYEAPKGKNWTDFISPSYPSFQPNVFSDTFCTVKQVGGFGGIDSAYVTTSNVPMKSDTLSCNRDFLSIQGRPDIRAQINERSTDKNSPLYMSRDTIESIFRASELKYPDLMELPETATSTFVPCDVAVKLQEMMYEEASKTIKVFEDDGDHFAEKLFAPPWPSDFVEVHPLDGHGQRFHKVTNGDFGFWMFLCITGRVRDLWQAIASSVEDNRSWHGHWLQFASNVLTIPGKTAKSRYFPALAEKKVHDLFPVRLEDTLNDKAKTADLFCSCRSVFVVEGSLSQVEASDQELEGKEVVICVNPKYPEVTTDRAESFELRCLVSGNLDNRQMFVRHKGQKFWVQNGALHLCRYEGADLHDGAYLGARIAVFCPRRSVGKLTSLKRRYLAAIGGQRCVHCDVHKCPLVLNHHHKKSSENTYKCVCREGWQHNRDEVCGQFGSYSCPYLDCCNISICDNHLSKSRNRCNSIGPEAAMFLSEVGSCFFSNDGVSDDGAFRGRCESSIANHVLPEALGPTAGHELPQDIVGEYGANCIMEDNSDSGSSFGSYDMVAEDNLEEPWNFVAAPTNDEDQQRVVVGDQEHNNSVNRSHVSEHFGAEDLPTTTIPTTTTGTDQCEIAVDGGQFIQRGHTDNHPRQQGMMLFQHNNTGIHLDSGSTFHLRTNEDDFKEESLQRIHGGFHYASNVEGRELYREGIDKVFDSVCKLDTRASDNVNSLSNMVQDGFDVFMDTKRENSFFVTRNGTTWRFGHRNGLYTLVDEPAVATAMFHNHARGIDNAGVDPRFDIEIERYKGMAFILQRDRINIGEPMNGYHDLWKWTKFAQWCYELAKDRRWDFDDLDIFSRLTVTFAEEAKRRGIRKDFHEWTDGRGFIYDEVPAGMELDEIHIVPNNLNDNMEGYCALQSVEKNKEGFTNKQVKRANVARSGYHMMGAPGAELFKLAIRGNFFKNCPITEEDVNISEKIYGPSVSTIKGKQKRPTPKAVVDDWIEMPKELLKHNLNLDLCIDIMFINNVAFFVSIDKAIKFRFSTELKDRTKDAIYKSIDKILRIYNHAEFRIKTIYCDNEFKPVFDDVKDNLDVTVNYAAPGEHEPTIERSNQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT16</accession>
    <name>A0AAD2CT16_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="107" mass="12535" checksum="4DF889195597B6DA" modified="2024-05-29" version="1">MSEADSNEEKEEKPVPKGYKRKKTVPPVSFLLKHGDPETADKKMSWRELYGPPVMIMITFVLSFFVFYYFIENHTTHRPITLPRMPRQAAKVTRKHTEGLPKRDSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU16</accession>
    <name>A0AAD2CU16_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="174" mass="20043" checksum="6985403DF8F6984C" modified="2024-05-29" version="1">MNKISQSVVKSTRRGSFQELKKASRKAVAFDQSVLVFEVDHSVTEEERNDMFYTDEDMRSFKTEIWRFQELAENSFSQQMMSSPTASAADADTWCPACYSGLEGFLNPEHKMKHRLQGVLSVLMEQDRQYKEQGLFTPVDFESMSHSYHMASKESQEEAHQRALTHRKVVSMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUB6</accession>
    <name>A0AAD2CUB6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="732" mass="83543" checksum="34C0D5B4E5F335DF" modified="2024-05-29" version="1">MIHRSARVDVRTKSGSLTSRSNSTKSKATPLLQRRRHTFWALILGSLLSCYLATVVLLSENGSSAFTTSSENPLSTFSMGNEWKAFSSSESHKNRKRSNGRVTQNQTVLLYIDGEISAEDEKAAANSLQSLVNQFGSQSLQKWEVIRQADNQEKNFDIATQNLPCVWITKKGPVQSSLGSNPSGRNVHSRCIQMVATAASDDPTNSSMDWRLHKQGSVGSTKPGRSNSNSTICLPRQVGPRQDFWQRGVNFERVGLWMQAASIRSYVWNLALVPDSQEQWLSDAIHKVGKESFSDGRNASGIVITKPLDDYKPVPYFRDLLTSVFTVVVFKPESAVSSQQNITPQGRKQRNKKQRKESPGQHKSMFWKQLQEVILSGSIPIVITMGSPNAQMDCNHELFFGSNSPILVLPNQMKPLLTTLWEEPPAKLNARQDELRVWYQRTMIQRAIQVEDWILDTTPSSKAPSSDQRLQLAKEYLQDLTPFFLQQRRHAAKPLCLTPPFYGRTNNKVIEIGKLLKLSYQEGKHRALALDRRWSNWYRPHFDERDDVLLDYYPHGECEKTFTAREAFEITDWDLSYLIHLLPRHDYRERAEKIINTWQHGNNYISVHRRDLEGSCHVHAKCSDVELETSTCLQKRDPTEICSAELRLRACDMEYNMVPNPEGLPIVLFTDGQVPAKDGTFPHMFNTTDFFVEMWLMVKSKTHWGNPRSTVDAVVSSWREGREMEPKECYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUP1</accession>
    <name>A0AAD2CUP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="189"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1942244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="662" mass="77129" checksum="777319AEABA164B9" modified="2024-05-29" version="1">MITMQPPVEKTGTVVLEWTKKALTSDVIPMIKKELEQGGILLIPNTTPEVELLTVTQASLERQAQNERLIKRRRITDTEFIMDHFQVANRSQFLMAVPGRDPNQLFTQKERSLLVLGILEDISIKNNVKLKEQLVQQTNKANTNILRYILESQGWIQKLAPVHFDEAKEKIQKATMWPLWQIMPPVLQIEEYYGPTVAYYFAFVGFLAQWSGYLGIIGLSTFLLRVYRQDTIDEDEYTPFYGLICFLWAILFYIFWQRNEAVLAYQFGTLELSTSLEDDEVPDDPVVHKRPEYHGKVRESPVTGKYEIYYPSINRKLHYVVSALVTVIMLVVAFTVMIISLNVQGYIRPRSDDDYHPFYWPRVASMAGTGELFDAMSSWKSFLPVIIHALSIMTLNKIYRKIATKLTDWENHQSQTDYDNSLILKRFLFEAFDCYIALFYLAFYACDIEQLRSELIAVFNIDSFRRVLTEVAIPMIAHRVTKKAKVEGHPQDLDLEVYESFDDWMEVLIQFGYVTLFASAYPMASLVMSVALMIELRSDCYKLTYLCQKPKGEQVSSIGMWKRLLQFMVWFSCLTNCLLFGFTSDQMLHYMPDFYMRDEEGNTHIVQDKGWMAILIIFALERVLIYIGLALTTLIPTIPEQLLIKLKRRKYLLHMNQKKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUT2</accession>
    <name>A0AAD2CUT2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUT2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041910123" evidence="1">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="207" mass="22478" checksum="F8C85DA80D2E0EC3" modified="2024-05-29" version="1">MKAGISVSIFTLLTSFLSSDVSAQLPSQDDEQNLSTLLHSKTQACNENGMVSAWCDSSMSAVECLIHPESNVYACMCTDPSSCPDECIETTDGDENSRLVKKSHHGIMCHGIPQDEPNYVLKHSADQLPSLHHCENNALVANWCNEVDFPGVSCLVLPALDEYVCTCIGRTAACPSECVNGETADRKTHNAIRCRGIPVDSPNYILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBY3</accession>
    <name>A0AAD2FBY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000086">
        <property type="protein sequence ID" value="CAJ1929538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBY3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="241" mass="27613" checksum="E394334C3D5B6765" modified="2024-05-29" version="1">MKLAKVLTNISMKKLKYAISFVYVGDITPPTEQPLSYYITVPHILETLETYYYPGSQRGEEIMKQDNMYVYFDNKTLSIAIDALRRGLGKATSYRWDMTKYEFLRSKKKLFKYKVFDTNDQNLIVMSGFDTSMPDASLLDNLYPHKKGMTLYKWDINVVYNAVGNVTRFLWTKMHILNAPSTKSLKYAIGSGLIKNCPITKEAINHAEAIFGPDASTLKGKSTRPTPKKTHDDFFSPPEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDU4</accession>
    <name>A0AAD2FDU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="410" mass="46737" checksum="5ED78F3119A4F974" modified="2024-05-29" version="1">MKFWKGDSDSDSDSDSDSDSDSDRSSSSLEDEAKEENSFQTESKQQERGVFQTSTKEPSRSLSKDPDEAWRQISSDQTFADLPYADSAKKDPNSVRLVCMSDTHGKHREVELPPGDILIHGGDFSKSGETGSMKDLSAYFEESGFAEVICIAGNHDLPLHAEFYKENWKRFHRRQPFDIQDAKDSIRNCEYLEDSSYTSQRGIEFYGSPWSPFFFGWAFNLYRGKEIMAKWKLIPNFTDVLITHGPPLGRGDFTSNGVRAGCYDLLMELQERIVPRVHIFGHIHEGAGVTYDSKTLYINASNLNISYQAINYPVVVDLPIDTTQPPKIVRPNCIMNPTEFVEWCSNESFDLIANAIRDDDEKMQEMPSGNQLFTEDAYEDIVNLFHLHRDRKVCAELKRALAKLYAQSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FET3</accession>
    <name>A0AAD2FET3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000471">
        <property type="protein sequence ID" value="CAJ1935441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FET3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="109" mass="12338" checksum="887D7FA8B4CB3497" modified="2024-05-29" version="1" fragment="single">GVELLEGLRFKLRMMGVPIQGYCHTCVDNMSVVKNSSVPESQLKKKLNAVAYHYVHSRCAIDILQIEWIISAENLANVLTKIQAGTVRDRLMENIMWKAKRNGKLALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHC0</accession>
    <name>A0AAD2FHC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protochlorophyllide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS6441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042175888" description="Protochlorophyllide reductase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1939127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32489" checksum="8F32F7DCA3BB7FB9" modified="2024-05-29" version="1">MKILPLLVASTLLFSLLDMSSALARTILITGATDGIGQHTAKKLAADGNILLVHGRRPNVGADLVQDLKTRGAKEVYYFNADLSDLDQVHVLAKEVSETTEAIDVLINNAGVFDPTPAHSVQGYDMTWAVNVMTPFLLTRKLLPLVANSKDDCPRIITTSSISQSSSLPPLEELFETNEIAKSGHRAYSDSKLGDLMFTVQLAKILMKSADEKYQKIKCLTMDPGTVNTKMLLAGWGACGIDVRDANNTYKLATEYGAKQESGTYHFGGRGSSDAKSDDKLNSLWKALETHTGCTYDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI89</accession>
    <name>A0AAD2FI89_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000957">
        <property type="protein sequence ID" value="CAJ1940785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI89"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="154" mass="17318" checksum="266FC4F2B86AB187" modified="2024-05-29" version="1">MTQTIKNTNIGTISSGLQTPTNRQILTLVTPPESPSKNQKSVDVNGRKRQRTVKACEDESLFLPMLNDCDSPVCFPRYRRSAQTDEICTRPPASPTVVPLPSHFDDDYDDKSPSIFSLAPRYQGERIIDMSEVTSNKRFRLTPSTKSIFLPLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK32</accession>
    <name>A0AAD2FK32_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK32"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1023" mass="108509" checksum="03AD6D56FCF7217B" modified="2024-05-29" version="1">MANQAPKDDLTTAEVTPTSTDEEAPSNESEGSLDNVSNHGDKPEEEKESCGWRVYYWVGMLSAFGLGAIIMFAVMKSRESSTSPSKAIPEAPIVNDEDVSNPTDVSGLPQLQESKDFPLQLCFGDCDTDADCDLNLRCFQRDPNEAVPGCEGGLDDESRTDFCVPIVLPEVEETNNFPLGLCQGDCDTADDCEAGLVCFQRSANDEVPGCLGSKLDSSNTDYCIPEETEGFFLKKLGQRLLGGKGDSFGFSTSLSRDGSTLAVGAIDAGSAGYVALYQLIDAKSWKFVTKIEGDNIGSEFGHSVSLSGDGNFLAVGVPKAPSGYIRNVGKVLVYELLLNEFGTKWNIVGEIESDNPNIGTYLGFEFGQSVALSSDGSVLAVGEPLDGRITLFRSFNGTWPKIGNSIQLADLAGRSLSLSDDGSRIAISGETQGGIFDFDGSDWAQSTPTQATDNIFQDGGTSIVLSGDGSTVAIGRVDNGVGEIVIQTFQYPVDSVWNALGVPVRLISGDSTVPNIVLSQDGRVLVVGDPHFDGVGRIALFSFDESMNEWQQTDSVVGRAFNEMFGVSLAIAQDATGSTKVAIGSPYPVQMIGSFGSAVVYKIEYGEKAAETSAPTVAPTTSSPAIFEQVDSWKGLQGETAGKDVDISKNGRVLAYSVTQIGSSGYVESFQRNDETSEWERMQRLDETGVNFGHSISLSSDGKVIAVGIPGGNTVDGNISGRVRVYSLNETVSEWIQIGNDIASEPFDPNASFGGDGFGHSVSLSSSGNIVAIGSPYGTSHTVVYRLEGGAWRMRGDKIRYSVSPALEGWSVSISDDGNMVAVGAPTNEEVSDEAGVCIIYEYIDGSWQRRGQPLFGDAQHDVFGTSVSLSGDGDIVSVGSINNDNENGEDAGHVRVYRFNRSTDIWERLGQPILGAANSDRFGVSISLSNDGMTIAVGARGHGLGGQVQLFQFDEKNTMWKQLGPAMNGNVENGAFGAAVSLSEAAEEFTLAVGAPDTMDETLLGLVRDPIGEVFLYEGVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLM4</accession>
    <name>A0AAD2FLM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001087">
        <property type="protein sequence ID" value="CAJ1941834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="288" mass="31549" checksum="EC2415DF83555E20" modified="2024-05-29" version="1" fragment="single">MDQGNDPTQANAVPDGANQGNTGGNQPAAANQPAAANQPAAAAANQPAAAADPQQQQQMIAQLIAQNTMLVNQLTNFMTQMQQPAQQPVIIVDLHQTGSAYNLAQRNGLAAFQEASAALLHKYDGSNATYPNFLNALQQRAAQCFWDAVANSGGITTYGGKDLFTQINDITEQELRNAYAARQNDRAKQKSLALYKCWDMTKYEFLRSKRNYLRNNARCPNPHIVEEFERFKGEPTIAKAQSKFKDRLASTPANLKGAKAHDSPENLNPSNEPMEFVEIVWHALTTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLP1</accession>
    <name>A0AAD2FLP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="368"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="505" mass="56041" checksum="A3ED5DFE818FB11E" modified="2024-05-29" version="1">MSRNSLSTEDLEKKLPSWVQEIPPSNSSNDIPLMRHCSEDSFTSNESSCSLTLDKSSTHSSQEHQFDWCPSSNRSSDSSNASSSDSVHSIIENLPLHEVPEMEESETSIGSSSPTYFSPHPFRKKLANKDDVLRRWSDSADVSLPTWIESDCSSSSDSSPPTSANTCGLDQILEEEDSGLEEETPRKVFHANPQRERSAFSVAVLIFCAISVIYYYFSRCTLAENLKNSRELLAYTQKLGLQLKIAQKDVELMELELASLDEIDAPATGLEDPSSSEAWTKALADPERMREMITVQRSLKRSQYQSEHLKEIVKETSKADAISTYGAVTKRVRIELAFPDDQDFAQGVGSSHANIEPTVFVIEMAPIDLMPHSVYTFLEMASAGLLDGCSFILNAMHVLKAAPLPYDGTPPSIKAQEFLDKGLESVAFREYSADYPHKQYTVGFAADGSPSFYINTEDNSEIHAGYPCFAKVVSGFETIHRLEASPTRNGLWLEQRVGIKKVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM29</accession>
    <name>A0AAD2FM29_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS8794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1944249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="563" mass="63205" checksum="51C93F798964FA0C" modified="2024-05-29" version="1">MESDHTDDSRQSLPSKKTQKRRRTSKGWTRSGFGQEIIDLTLSDSDSEGQSDQHASENVDELLDIEVAMQQMERTVHDHAGNVNSNNNNNDTSDDNAEKEGFLSSDSSDHSVDGTSIKAQASVNDDKVPDEDKAMPPTIGSLYRKGDGTVLGVRAVDVEKRQATCHDFVPSQSTSHDRHELVDGFAIVPFKELPLSCLVEDWCYTFDSEIKHEFSICRKFRKKVRLSSSEKKKRSLNRDKPPRTLELFSGAGGMSQGLLAAGVDVRWAVEKDGHAVGTLRGNLSKRHKTNFFRECVYHFLDKSKSREYKAYPRQDEVDHIHASPPCQGVSRANRYGGKDDKNNNKLSFALVEAVRHFRPKTATYENVMGLATKAHRQILFGMIADLCALNFQVRLCVLDASEYGDAQVRKRIIIFAADETMLLPPRPPPTHGDERHMHNVRTVGDAIGALSDITADDKGCVTIQGIEIEDHCAPQSKNLNEDHPDNTKLSADRPAPTVMSQNRFIHYKLNRYLSVREYASLQSFPLTWTFCGSEDQKFRQIGNAVPVHMATRIAESVMLAYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMM8</accession>
    <name>A0AAD2FMM8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001630">
        <property type="protein sequence ID" value="CAJ1946166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMM8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="316" mass="33625" checksum="ACBD9AA559BD48A1" modified="2024-05-29" version="1" fragment="single">MEHQRNNSGASSADSAGNSEGGGDMVQKSREKRFSRDIRNERRRRVTTCGSEWKPYQFHSPVPNTTNARATAAYSSGGGGGGVGVGAFEELLKEFSTPQSEDGKSPTRGEVNGGGSADKKDDDDDGDMSPPKPMLQSQNSISPQQLLSTQPITPPTRNTDSTSKQTPHPSSGGLVSRKDDSSMIPTPNPPNSPHPRANQRTAVATAINTTFATGSAPSRAPLAAAPAARPIIANAYRKTTLPKPAAAKENALPAVLNSSRGLQPTIANRRIIPEPGRQNLTNTLKQPLQQQRHTMTQSINPYSKKKTKNITAATQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNX1</accession>
    <name>A0AAD2FNX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001734">
        <property type="protein sequence ID" value="CAJ1947609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="427" mass="47813" checksum="EDCDEB58F43DF0ED" modified="2024-05-29" version="1">MVNVSLSSSLSSTPHKKKRPITSMAPLTTNFLIVFLALMVLACLWVNLMFSIPLSGSPPLTADCNGSSKRRTSEIRGLSSQQPLLAYNGSSMATVMGMATGYDLAVYKQFIGSLRRTGYSGNIILVISPDPAPGVEDYLSSNGVVMKRLQKVECDTQIIANQENAAYANSHQKEVMTCAHPYPNLKVRWGRFPILRDHLEACSTCTGPVLVTDVRDAFFQQDPFGEGAPMITGLQVFEEFKFQRTTHWLVKTPVSKCRGIEIDETMLCSGTTIGTRTAMLDYLETMHLEMVDWMKDPKCCCNPINGDDQSIHNYLFYTGRFSDAQAIKNRMGIVHTVGHQATLIFRAHEASLARDFPQNYTKDMAYKIPLSATSSDQSKSWLGIEYDLVDKDGYFLNYDGSRSRVVHQYDRFRSQIKKWLKANIGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPQ5</accession>
    <name>A0AAD2FPQ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS11716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001748">
        <property type="protein sequence ID" value="CAJ1948641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="260"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1948641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="510" mass="56475" checksum="5FDB757FBC4B649C" modified="2024-05-29" version="1">MEEETATKVGQSEKDSNPPLIAAAKRLERLLGGGLQSKNRSVHTYTNPAKVVRRWLGTASGAAGTASPDEIAQAAVVLLDPIGICSRGRSFLTDGFSADGLAGTGKDEEKIYLTIASSREIESWLISLLVRCLRKKGKASEAYELSEKGVETIAMHLSVASPGIPSTGASTTSLFPLLARMYRYRSLCATALNDQNLNDRLRADMAKAHNMACVRRDVDCQATLLNLMLADLIVHSQIEQAHKLLSNSAFPESASNNQMCRYMFHSGRIQSLRLEYTKAFSNLSQCLRKAPTNTGLGFRTAAQRLLVVVQLLMGEIPDRQVFFTKGMQTELAPYLAITQAVRRGDLVVFNSVVSEQASLLQKDNTYILISRLAHQVVKAGLRKLHMSYSRLSLQDVADRLGLPSAKSAEFVVAKAVRDGVLDATIHHKEGYVQSHDLVDIYATKEPTEAFHRRIAYCLTTHNDAVRGMRYPPDAYKKQLEASRGNRRKRNDDKTDEEKAQEIEDELDEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQD7</accession>
    <name>A0AAD2FQD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS12126</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42697">
        <property type="entry name" value="ENDONUCLEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42697:SF1">
        <property type="entry name" value="ENDONUCLEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="587"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1949498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="632" mass="69717" checksum="44E403A2393A131F" modified="2024-05-29" version="1">MPVLFSWTKSKRRPFFWTACKTTATAALFLTSQSQHSVSAFGVVRQQVRMVEGHSVHRVATLHRQRLVGKKFTAWSPNGRFTDGANAINGKTFSRIEAHGKNLFCFFGDDINQKRISDIARKAACATDEEQDDDDSVVVVHVHFGMAGAWAVYLAGETPPEPTPTNRLRLEYDGTVADLSAMTVQHGGLELYRTKLAKLGEDPLRKDANPATLWARIQKSKKGIGALIMDQSFFTGPGNIYRAEILFKAGVHPNRPGLSLEREEFNRVWEQTVLLLERGYETGSILTVDPEEAKALGKPRLRRYIYNTAKCPRCGTSIQSWPINNRTCYACPRCQPLTPRTSTETPPPTSKPVTTDHVPFNSHCARESTAFRLKETGPSRLTVKEIKQELTRLGVSIPSDAKKKAQLAELLLKHLPESEDAETSSKTSPEVDPSSQDLTFISSEDAALEKAQAGENLAVEHIAELGPSQARRARYQGPSRTRLTTTCSANMKVKEIKDELTRLGVQIPPKAKKAELMDLLHETVKKEDKTILEAVSPKASTPKRERRATTTASSGPAPAFVSPEDAALEKARAGENLAVEHIAELGPGQARMARSRVLFPKGGDEVASTRTTRTKRPAPSAPTAKKSRRRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSU2</accession>
    <name>A0AAD2FSU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS13543</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSU2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="85"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="303"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1952418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="648" mass="73662" checksum="827C91D314C07513" modified="2024-05-29" version="1">MPSRSSSSRRQTMATLNPMSTTNSSRRQTIDPSSAVGSTSKSRPPRGRKSMIPSVGRENLNPATPQSARPMKHSTSTGNHRRRSSIGGDRRQSLVPPSMPARTDPRPLSDRSYQQECAKRLLDFLSKSNYDHPISPKSLRSPSGKDFMNIVTFMLRLVDPNFHKDSSMKVEDEISMSFRAMGYPFTVSKTILVAAGSPHSWSTLLAALTWLMERIECMENCKDDDDDPGQFESVEELEAKTDKAFFKYLSAAYTAFLRGDEKETEDLENALGDRFERDDELIAQEIQIMDDKNGVVLEELTELERAEEDLQHHITRREDLVQSLEGLGDVMTPMSDELEERERQKSELTNKLEETNRQLERVTSRIEELKASIDSQELSVEDTMKMKNELKGIEEAYDRTITLRDQRRKALWDIDDELKKSWNDLETVLSDYNAQLSELNLLPLVSAKSINMRASLDKAAVDDADTAKLIGVDLVSSVIPALSSSKQQYNEKLSESKWKYQEALDKLESSEEGFTESHDKLKIIDAKIGKCEETLQAERNANDGKLAVRVREALSMETRVAALRDPVALEEQMAQYERQCTELESLRQKHEEQNIARKRDVSGEIQRACNAIMEYDERCSKQISEIHKYRNDVEGAMGELNVPENRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSY7</accession>
    <name>A0AAD2FSY7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="438" mass="49505" checksum="0DDC9CAE7EEA74A1" modified="2024-05-29" version="1">MDSNSTPKRRRINNPEYSHQGKLHAAEQSVTVPLDVIILMPSAFFQYRNIIEIDLPETLRTIRKNAFYRCISLTGISIPPFVEDIDDGAFQHCTSLMGVELPDTTRSLNLEKEIFKGCKALVNISFPPNIFITGYDVCKRCDSLFKFPEPARDDYGDLKSFLYERFKNLPVHKACYHARSTTVDHLLAAIGSDRGYPNYPIDVYEMGPMHVVASSAILRIDLMETLIDKYEMRRLHDKDGHGKTAMDYLLANRASKSAEMIKMVLKRTFKPFGWTGWGLEKWQSVLCAEIESKSWDGNFDSRRECLRELAKKVSTYGKVEMSSLLELALWKVEMNQGDSDRDSSRMTCGSNVVIGNVFGYISDDSTTATASSTINFMGWYLEWLEGVFQESDSSSDESESSLSVDDDASSSSEEEVFTAFEDSVEEVASSSSADEYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTX4</accession>
    <name>A0AAD2FTX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042220369" description="Glutaredoxin-like protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="152" mass="17314" checksum="EFC866CEFAB73223" modified="2024-05-29" version="1">MVFLAACIRALPSANAFLVRPNTRAPIGAWSNSRCFASVTGNVYTADAKDDSPTVRLFTKEGCTLCDKVKDVLIQVREEFPHNLDQIDITDSEHKEWFDKYKYDIPVLHMETKFWIKHRMTLEEAREGIQEAMNGAFGERKGDPNAAAYERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUH2</accession>
    <name>A0AAD2FUH2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS14343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUH2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1953740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="168" mass="19842" checksum="6124F6007F1A6029" modified="2024-05-29" version="1">MDSDSSQSDKSNDPLETARWTNYLPETFGIRDAVKQSSYRWCVREGGMWGLATASGMSLHRLRMGSRPIVAGHFFFGTFMTVMLPSYYFCYRRREHHEEVIEAMMKYNKFGHAKEMPEEIPLQEHPFWGESDGSSESKHDREFRGMIKERKEWQKPQDQSLEEIFKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVL4</accession>
    <name>A0AAD2FVL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS14714</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051559">
        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF26">
        <property type="entry name" value="HIF PROLYL HYDROXYLASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041934422" description="Fe2OG dioxygenase domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="274"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1954119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="410" mass="46452" checksum="4905D47852DF8688" modified="2024-05-29" version="1">MRIDISLLSLATLAQTASGLATVANTREIVFPLKTNQHKDLQLRNVKYAFQELVESTDFFVQNSPAQFYDSTCLVPALGAEAAFQFQQSTPSDLFPHWSTELVLKVNTNANSDFGWICAKVFEQKELFEDFVDTTNLYEAVVDHYNSLGPHPGFPASSAELSNSPKLNDLFREQDFCMEQLRDTGFVVLDNAPKTSVAGHRLLDQFLHHKTNQDTNVRTDSVHFLSRKEAQSCGFEEHYDTLMGIASYLNGNLEMKTSPHDPMNPATQEHPLTIPNSIQLAEYAESDFYKAHSDNSLTNKMVSDVQNNDRVRANFRHYTCILYCNDDWEEQDGGALRLYPHTRNLSNANDAILNGYDFFDVSPKNGRLVIFDSSNIHSVEKVTHTTKKRRALTLWITRPNNSGVEGEQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW01</accession>
    <name>A0AAD2FW01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS15240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW01"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041782227" description="GDT1 family protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1954649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="286" mass="31155" checksum="5E20DD4987EB9C6B" modified="2024-05-29" version="1">MMLSRRSLLLLLLCCTLWTTCAQELPPSGLFDRLDENHDSKLSKEEFSHGWKVIAQQFPTGGWLPVSKGGFWKGFTAGVSMIIATEIGDKTFFIAAVMSMRQQRSAVFLGAVLALYVMTVLSTLMGLVLPTMIPVKYTHILGGFLFLYFGFKLINDSRSMDANAVSEELEEVEEELLHPKKDEESGQSSVPTSPMKTGFAEVAIQSFSLTFLAEWGDRSQIATIALAAAKNPYGVTLGGCIGHTMCTGVAVLGGRMLAARISERTVSLGGGFIFLVFGIHSVFFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXT9</accession>
    <name>A0AAD2FXT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS16003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1955958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXT9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="301"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1955958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="530" mass="59283" checksum="0FB53C5759FEA6ED" modified="2024-05-29" version="1">MAATTTSSPTSVTMEEPYALDHKVSSLRQSISMKRNTSNLTSVERIFVDEIMEEGDEEDLEVLLTTLEDQTLFFGSSHGNGEEGKEIMLMLEPPTGPQHLLLRGQRGSILRQQTIEKRRSCHQRNSLWRRSSMKKMDSFGSASTNERNSFSGGSGEFSVASSSGGNSIKQGDRSSSKVVGPQSLFTLDEFKELEASYGQDEEEDHDENGKIGTHNETKVEELVVPQTTSSTDSSDLIKRASRNIYLGEGFEVGAEDLFNMYSQSMPDYDPWRDNLEMDEEGHRFDFTILGTSPDDIDSQPHALSPPQMYALQEHLPMARKGESFWLKYSMVRDGASFSALLQHVRGSHHTVMCMETIDGEVFGAFSSTTWSIQPNYFGNGECFLWRMKSNRAEVNGLSLYEQAQQESDIAVYPYAYRNDYYQLCQHDRIGLGGGTASVPQEIQGEMVEPNQLGFGIMFEGSNLLEASSAPCLTFGSPSLSMIHSDGSKFELVNLEVWALTPCVTIEEARRLECQRLFLKRNLVNSNSTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXZ4</accession>
    <name>A0AAD2FXZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="432" mass="47913" checksum="D5209AB6EDCBA81A" modified="2024-05-29" version="1">MAGIKALKKAIRATQHDPPGVTKQTMDQGDGLSKRKKKKNAAKKLKAFWEKKKQQQKNLSPNADEVSLKDAAMQLPTGKTRHQTAGKPSDVLSPRTAPESVDSPLHRLPVLPNPNHPEHYTAEQIFRRQQEAPGTKGMEIMEVVVPSDYDAQIGNISPISMDNSAFYPQSRSLRQQSGVPGRFDPPTTHYTEGLGVELALQLPSLQQRTRRGGGIVSEDLASETESSTRGRSRERARSVSAFSRRRIRPNSGDRTRHDDEPQEVDPIFSTAIDLTDVENEEQAMKLVLRLNGPANAFDNISNPLTAVPNVFGSLTDLLKDPPVAGEEDDRSEVIGSFKADSSKGEVDERDERVKRETVDVMKKESTKGAPFDPIDLTECDFRLLVRKPAEAINVGFVEDADDAYDEMIQTSHSIVTKATHRMLGRNNTWYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYE1</accession>
    <name>A0AAD2FYE1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS15675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041999339" evidence="10">
        <location>
            <begin position="29"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1955283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="394" mass="44142" checksum="E240F52974FFC6F1" modified="2024-05-29" version="1">MVANKQLKRYMSSGIVALALLASHCTEAFVPSAPRLASNSLETSHVVAPNVMGVAVRKKETQLDMFMGSDGGILGIGTPELFTILLVGYFVLGPSDLYKVTKEIGKFVQNVRSFSADATATLENNLESQLQLDEIRKAQRELNDAFSFRRSINVDSDSEAFEVNAKSPRPEEPEPLAASVSAPNETGTPKKKIRRRRVKKKKAVDEEPFSMENVDSNITPNVPDLDMDAEMMESEERMMASLSGANEELRNEQMEDDAAKLRKERMERLQSGSTESEMAEQEMAAEGYDMPSIPDGVAQNRFQAQLNKNWNEQIMSKEDELGPVADIMKRLAILEEEKIAVDKRLQEEFKLREENEERFYREKRQLLEDAAAQFQTEAFATTGPSSTPNNSTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYW5</accession>
    <name>A0AAD2FYW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="99" mass="11423" checksum="F8E38031FE221B02" modified="2024-05-29" version="1">MVMGLKPAPDVAQYYIEKTLHGLKEQGVEVYIDDVGLFSNSYEEHMELIKTVVERLQEAGFKINPLKCEWCVQETDVKPWKKKVDAILKMNAPRNITEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ04</accession>
    <name>A0AAD2FZ04_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mechanosensitive ion channel MscS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS16820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ04"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="5">
        <location>
            <begin position="760"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1957658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="985" mass="109399" checksum="29F50630FE7DC546" modified="2024-05-29" version="1">MEEIPKTIAVMDDVSENADDTLRAKNQNADGHHRGISNLSSDPIVFDPPQASASTAKHPLKRGISIGSDAKQSLADSARLCMEHNRMSSSENQKITLDNLLQNNQYEHEATTHILKTLEEQFDSSQAFETSILEGVSDEASRAMEDSSALLKPSATGHATTRTQDRKPLLSSRPNHRRAMTVDDQLADLADQMVDHGFHAGPDQTPAIASHSEFDRNTQLAFGSADFAQTTGKGRGRLFSRDKPTLDPVTNDVAVDLEAGKASHNMPQEAGRKSFKDAPQRTESDSSGMKGSNPYNSPLSNMTEKVKSDVASWKYFFRPQQATIKKYIKIMLYIVLPLVGVAGLLYYFLDNPTTSSSEGQSVSWVILFVVRLSVTLTIALAIQALVIDLLCVQTRIIPRLVGPLFTLWIVQSQGWPFVIFMWSILNFGMLYGQSAFAAHWLFWQDTVPLFSETNPAGGIIYSDIYRAVLTIGATVPVAVSVKRVVVGLFLGRKSFLHFGESLAKVMDKMLLVSQVAKLAKQRTLQRGSTDMTAYQDMLNQDDDGSSARNGKALDLLESEKHKLAQMLDRWEEPERRSTGHKKASIAAVLRFRNALALIHNDYPFSFAFGPASNRNECVESAQNVFKQLLAQGETDVEFETIAASLAVREGHMLNPERVKSLIRVFRPNRDGSLSVLDFAKSVDAVYKEFRLLQASIENSAQIDRAFDAIFNTIFYVLVVVIIMSQLGLDPMAMFLSLSSVLLAFAFVIGPAASKYFEGILFILLRRPYNIGDLICATNIQAEPGLMGNIGWFVQNVTLFETTITWLPTMETASVANGELASSRIVNWARSPNARFVINLYFPIETKYETLTLFRGALEEYMKARPREWLAFNALRVLGVYTEKGYILIELVVQHREAWQNPGAIYDSRGNLVSFCHEVQKLLGMQFKNPPLPVDIRNGSALEALDAMGQERGPTVGLPNTSGGGTEQAAREKFRQTAETKHKMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZI2</accession>
    <name>A0AAD2FZI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001956">
        <property type="protein sequence ID" value="CAJ1957781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1957781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="307" mass="35199" checksum="422EA6B307967227" modified="2024-05-29" version="1">MYVADTKQSRLDPQFIQECVTLPALRSRWRDKGTISAEAESEIAWDTMGRAMRSLPAGLQRWSTKHCVGMCGTGKFKVLWGLETSAACPRCGDFEDHPRCRAALATAEWDRCTVAFSVWLDLQLTGPSIKIAILQLLQGVLTPPSFPPRPISSSVWPAFLAQQVIGSQGLLEGRIASSWLPLQQQYYDKIRCRRSVSLWASRLSQQLISIGFYMWEQRNSVQHSDDNVQLRERHSTVNEGIHSQFDMGPDDLPKEIQPMLTSRRRVLRKSLVDKEEWLKLLRQERRDFRRSMKAQRRSLRTIFSPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0F3</accession>
    <name>A0AAD2G0F3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS17323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0F3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1958732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="523" mass="56788" checksum="4D6F7169388E6815" modified="2024-05-29" version="1">MEIIHPEERWLEEMIEEDAGDPVLNMLSAIATNILLFFLVFGLSATVEVKSLKNQLTNKAAILTGCAMQFIIMPMLGFASVCMLRNSEEFTQAMGITLLVVTASPGGSFSNWWCSLFNADLALSVAMTSVSSVLSVGLLPANLILYSWLAFVVVMPNGNEVNIMDALDLKSIFISLGVVMAAIILGLYAGFVYSTPKFHKRANKFGSICGLLLILFSGFLGSGGGGGEANFWSLHWSFYVGTAFPCVAGMLLANVISRGFKLSLPETVAISIECCYQNTAIATSVAATMFSDPTTRTQAISVPLFYGLVEAFLIGIYCVWSWKLGWTKAPADEKLCVVITNTYELEDDDDVIEWQTEPVNPGWFKRLFIPRQTERNIEARISGGATCLSANVLGGKASRNRMDSTDCTVATARSRIDSTDNLIGNPSSPEIPIGDLVPQDTISEEGEPEDLDVESNEIKEDPPANNLASHEEAPKTPLSPAKLLRRISGQSQNRDGSYKALDMAGELNSAEFFVPLSPHVHKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0L5</accession>
    <name>A0AAD2G0L5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001983">
        <property type="protein sequence ID" value="CAJ1959260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0L5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="172" mass="19513" checksum="670505E4589278A0" modified="2024-05-29" version="1">MHLIMLYHVAYTASPASGEKLHRFIKESSIQERTGSSILIFSFTRDSNTWRLQALPNIAASISGLVRKLCFLEYSKLSIKIYFRFSSAGKHLLQAMRAAQCPAFRLPKNTGKRLTGWLVRARVMALLNKESKYWRLLQNSFFSICAFASSRWNVIADIPIVASLVNDSSGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1L3</accession>
    <name>A0AAD2G1L3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002020">
        <property type="protein sequence ID" value="CAJ1959776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1L3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="300" mass="35095" checksum="A1FF993C4D084873" modified="2024-05-29" version="1">MYDICRKAEARCRRVTNGAVPWSPQIQTFWDRQSLWKLLLKGRKQCQVSSRKIRRLMKKTKLPDAWKKTTVELETALRNDRKEYLHAKKNHAVSWRKEFLTVQVKKSKKKQWTSRKARDRFLRLRRMKQREEARRRRRAQSKGSTGGLQAIQVEETLPTGQVDLRTLTDRRQVKQGCMQENCARYDQTRSPYTTPPMDKPLYSMFTGADAERNSHALLEGRLPIPDGIDSYTKSFLEQCRFHQGHSMIPMEVLPDDHTYFWSCNPENKGLEPHGLHNGHFKAGIYSPMVAQCDLSSATYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G219</accession>
    <name>A0AAD2G219_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1960008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G219"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042029774" evidence="3">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="97" mass="9582" checksum="A024AF85DEC41F3E" modified="2024-05-29" version="1">MFKSVLTFVALVAVASAQSVAPAASGSAVPVAVPVAVPVMVPVMVPVMTPVAAPVMAGGKAPKAAKKAKTPSASKGSKLSASSASSKSSRRYLTHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2L1</accession>
    <name>A0AAD2G2L1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2L1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041929036" evidence="2">
        <location>
            <begin position="34"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="247" mass="27374" checksum="B725DFCBAE3EFEC0" modified="2024-05-29" version="1">MKTVFVPSARTRPMKTIVLALSMMQMLASTVQGESLGLVEQPFGHPYIHQHGHHTENHPAQPDGNQHDHGHHHRHSKKRGSKKSGKRYHPWNGNHLHSIHGKHGKRQGPDKNHHYEHSDLQKNDNNHDSDSHTILSAESFDTNPLHSPMSESSVSSTNSSSLSSSSSSSSSNAKNEQAYDKGADTTLSTTSKNTDKALSMSDMKVETLKISQAKTLLQTRIETETSKYHPDSIEINVISLHDEKHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2T8</accession>
    <name>A0AAD2G2T8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002060">
        <property type="protein sequence ID" value="CAJ1960514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2T8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="146" mass="16552" checksum="D07D202602B9AF4B" modified="2024-05-29" version="1">MISRPKVIVLPVTGQAIQRVEAWAAAGGVTSMKFFDKKRDLETFQGGDQIAGVDDTEQGYLEEAFDQDYEPEDEDERDFNLHGQFDDIDESKRNELLADADNDVDDMPDLIVRFQGDDDYKSDDDDSADEGDDKEEPIEENYVPCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3P9</accession>
    <name>A0AAD2G3P9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3P9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="274" mass="28702" checksum="83ECB6C2479AE5D9" modified="2024-05-29" version="1">MSSGDISQLTAMGFDEPSSRQALASANGNVETAVNILLGVIPAPAAPSSSSAASPSAADVGDMIVCPTSQYSVDNGRSACTCIALTAATDFLKLSGGGSVALNAEFLQNMIMNGVQNYQTLSSASPVEHLSAEEVLQKDQGKCFPLSVRGGIRQGILSSDSFHPMGMQALLEGIQQEQQGQSNAYIAVLITKTPETVLVCLPVSGSNSAHWLIDSHPRAAHLGADGSYAKPHPNLASLLLSLQAIFPPTELGPDIPEMMAMMYNSFDMYPLQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3V7</accession>
    <name>A0AAD2G3V7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3V7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF98">
        <property type="entry name" value="CUPIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="343"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1961855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="494" mass="57568" checksum="2286DAA423420C8C" modified="2024-05-29" version="1">MHRRPQSRAVSDGQYSSKSRTDDCALNGGDEDQSSKVRAKRTRKKRIKNEEDDPMVYILKGLAVIIVILIVVMLGIVAKLFHLKMWPSVKEYFLNPVQVPTPPQHNKEPLLESLLYNIPHSMSHIGDKSDEYALLRKDFDARLTYDPERSVAFVKNFRKPDVEPFENPLSYNVYNCPKKPPEGYPYQWKTFDVITDWKPNDVNPPSQIHQGICVFDYRKDYVKALNYRKAEVPFVVRGDPEVAQTIERWHTDDYISKLLGDAKHRCEYSETNQFMYWINRNKDKPPPGWKKPTKMLRITFDEWLKNANITDASKLAPDQPHYYFRLIGCGEIDPHGGCDDASSEFLFDELTFFQPRTSLYMVEPEKQRGIHCRFGMTGVTAENHFDGSRNMIVVLGGRRRYVLTHPQDCENLYLYPKGHPSARHSQIDWNNPDLDEYPLFQTARSNEVILQAGDVLYLPQHWFHFIVSLDLNFQCNTRSGKFRGYDEPIRECGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4P5</accession>
    <name>A0AAD2G4P5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4P5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042116975" description="DOMON domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="33369" checksum="0917AB5C660F9F4F" modified="2024-05-29" version="1">MKLSTFSAGLLATVVALLQTPTALGQIIDYSLAAPTCAITADDNVQCDFASILPLTGNLAFSITGYGDCTGTAARDGEMSLSAATATAVAGASTVSVDLNTGFTIADGASEAFEFCLLTSLKDGSGNEMFYQGQKISATFTADGGFTVAGITSEQFDGISGTIATDTKTFGVTATRCDGHDTRVPISTPALALGTTLFICLDTDDDSVVIQSVDTFLGSKTNVASTNLLSGNTEVLGANSAAATVGTRPFSTFFADADTIDIAGTVTLVVTSNNLRRRHLARILQTGADEFDVRVEVEPIEESSAPLAFSAVSIAFLGIVAAVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5N0</accession>
    <name>A0AAD2G5N0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5N0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="513" mass="57449" checksum="68B016A314278372" modified="2024-05-29" version="1">MRTRKKARLGFDANGVFVYSASAASNNYLQNQTLLVPRNVRITRVPGSVDRLFESAFEDCQELEEVMLEEGVEGLGRRTFLGCAMLTTVRFPSTLRTILDYAFYDCHSLSSVELPLSIEIIGIGAFENCSSLQHLDLSQHTRCTNIDKCAFQGCSELSVARLPPNIKGLFPMEVFCDCSALTHLRFPPGVTDISPSAVEGCSSLVSLEVPEGLWRLDVVPNITGGSDGIQSCSSLVNLFTPPEQWVVRSMDSLPFPPDFQLGRLAVAWRDLIPKLQRRFVDRPLHKLCYFQTYQYSTQDTILKMRDILEAHPIGAHAAAEQVDTFGMTPMHILMLAETPVMELVQELPTSIIETMIQAKDSFGSTPLDYRCKNAAGRQAIRTWLPTLLQQRLQYIGLEQWRQEVLTEQEKGVTLLVSDDAETSSRQVERVLRKLIQCEIREILSLLEMVLWKTKLLKTTTNDGNNAGDNDVRDGGEEESCISTHRQSCRVHSGISIVVENVLPFLLSSRTSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G653</accession>
    <name>A0AAD2G653_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate-semialdehyde dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="1">1.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NAD(+)-dependent succinic semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS20566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G653"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041929038" description="Succinate-semialdehyde dehydrogenase, mitochondrial" evidence="5">
        <location>
            <begin position="24"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="78"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1964305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="574" mass="62855" checksum="6CDBD44721D5CDD8" modified="2024-05-29" version="1">MKFSSHCLVGLLASSMMATGVVGQSCSATDPTCANIPYEMDFVAPKLTLHGKVIESHKDATDAMVTGCCSSDDNTSLTPEEIGKIPQMNADLTMQVLEDAKNAWKGGSGTWPQMSLKERMTAIINLLDELKTQRETIVRTLMWEIGKNRKDAESEFDRTLQFCNQLLDTVSKHPEYHGHWESVGSTHAFIKRAAIGIIMCLGPMNYPLNETYATLIPALLMGNVAIMKVPTVGGLSHLLTMEAFAKALPPGAMNFVSGRGRETMPPLMKTGDIDGLAFIGGSRAADDLIKQHPRPHRLKVFLQLEAKNMGIFLPSIFESKDEMSKALDQAMLGALSFNGQRCTALKLFFVPQKQGSAFATMMAKRVEEMSVGLPWQNWSSDESKSPSYSKITPLPDRKKVEYMQKLIQDAVSKGAKIINENGGEVIGGLKSSLMVPAVVYPVTPDMDLYYEEQFGPIIPIATYDSLDTILDYGHNGDFGQQVAIFSSESNSDDTSMLVDQFSSVFGKININSQCGRSPDTIPFSGRRSSAMGVMSVEHALQEFSIPTVVSYKESPSTAKLVKKVESSSKFFEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6E1</accession>
    <name>A0AAD2G6E1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002190">
        <property type="protein sequence ID" value="CAJ1964488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6E1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="13960" checksum="27D2CF205E45B2D5" modified="2024-05-29" version="1">MKQTLRLLTLYNGSSNVELLNSNEDACLPQQKKSGTDGICGVKETMATKQQAPRGLYSISNVSIEQKEKKLFARSHEVEVGLKTVAPMGTLVSEAEEHMKTLQHTIHHQDQLFSLPFLLSLFCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6F2</accession>
    <name>A0AAD2G6F2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6F2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="250" mass="27255" checksum="D33258FCD0E274D0" modified="2024-05-29" version="1">MALSPGGLAGLLLLGILMNLAIVVALYIWHYRQLKKGMVGIKFTFSDKLHGAFRWILFALITLCWMASIAATASCNFIKVTVPYVGQQIEFGMGFQKFYVPAAISNPAKCQGFASDGTGYFTGNHPAFTFAVANCLLTSVGFVGIVCIQFILRVVKTRQLVWLVCKIAMYCSVWCCICTFYVQEMGVCDDFGCSMGPAGIIQVFNVLALMISSALLFVTDCGDESAFDKCRTKTTIVRVPAGTMNAQRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6Q9</accession>
    <name>A0AAD2G6Q9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6Q9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042250907" description="VWFD domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="77187" checksum="C8CEA390B308A6C8" modified="2024-05-29" version="1">MMKSFLPLLLAVLLGTAFGYQQFFAAENAELEGDKAIFQSQEGDLEYDSMEEDYGQIQPESKLSKRQRRLSIERRRRAKKDSESKGSKSSKGSAKESEGCPPGFTAARRRTKKDSSVKSSKGGGCVAVASAPVVQPVGIAPLAPVAAPVAAPVTVPFTVPITAPASPPIASPVAVTISFSSVKGSGSGGGSKGSSKGSSKGSSKGSSKGAPVPVTAPTAVTSSAPVSIASSPAASSSAPIASFGTPSASGSLAPIASSGSIYVEATAEDCQAISSGGLVQGQNGMDSSTFTFSFDLQLNNGVSNMATVIATAKGALQALVAQGIVNCGSSSKGSKGSRRRLLKRGRVHHKHRHHRHHRHHKHERRLALDPLVIGNLLFDVQNCVETTDNCPVDATCLTCTATATVFVKGPASDEDLEAEITGFLQSPTFLSDSGLDQIASSFSATEAHHLDLEDVVTLQSDAGSRGDPHFTSWKGEHFEFHGQCDLVLAKDAEFAGGIGLDVQIRTKLVRYWSYIKTAAVRIGDDILEVEGSTDVETDLANYWINFDHQAKSKTIGGFPLAIYDDNARPFPKRRFEIDFDSKFPGQKLVIATYKEFVKVDFIQASAEAVGNTMGMLGDFRSGMTYARDQSTVIHDFNELGLEWQVRPDDDMMLFHDISYPQFPKPCLLPEDPRGERRRRMDESAIAEEEAEKACATLKDPLSIKDCVYDILATQDLDMVGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6R3</accession>
    <name>A0AAD2G6R3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS20233</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MLO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002149">
        <property type="protein sequence ID" value="CAJ1963582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004326">
        <property type="entry name" value="Mlo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942:SF127">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942">
        <property type="entry name" value="MLO-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03094">
        <property type="entry name" value="Mlo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="4" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="584"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1963582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1352" mass="151911" checksum="2C7271219E07C11B" modified="2024-05-29" version="1">MSQDYTKFDEGIDYTVLSIAVQTLALILFVEIVKHKLDHFAHGRAFFGTVLHSMYDELSTLGIVELVVYLALKYLRDYDQAKKGVFADVHFCLFYIAVFNAFQTVIVAMATKRTSTKQWVDTEKIDISHYIEIREEFDAVASKLGYEDDYEAANVATLKGFFQDVAQSVRSPGLRGHYLDLLVQVKFHGLRTHFLTANSLPLTLKVSDYLKRSEERVLSKLVHVSGGAWLMLTGCLSLAYFLMGMVAYVSEDQEVVGRFLKGIFFFMLLIFILISVAVYFKMKSTFHTIITTNYKMSKMDDKTRATGMKSQKDLFWLGEPQFVISMIQFMQFGYALALAVVLMYWKSFTTFEPYYFLLAVVACYSIFVFIVSRTLPQYTLCTSLGYLIDEKNLLETVALDRLEEARRLRIQSMAEANCEEDSIVSFESSERFGAKMRGDSTVSDDSGRITPTGIPNRSSILAELVQSDTQSLRTNLPTSVRQSLRDRESRRLEKRKSLSDGVGSMRLSLRSSKGESSRFLLESQPTSEHSDESQRTVDDSQILNQQRMERVATRKAQQRAMSESSVIQSWQGITKKERKLGGISLSKQSSSLSDSSSVAANDRSGSASLAKADQSSMRPSQRAGSFSTKETFGSEVQSTVKTVESDIHDETNLAAAAERTDDSVGALSDVDVKDWTPSEHTGTVDEKKYDYSFQGILAYTRSYLLGHRYHTFSHVFGSLVCFFLVGHRVEVMLSATGAIEPSANTWELDLSISFWVQAIWYGLFILSSILILILFLPIKVKSMDDKAIIAAGLFDFMLSGGCLAILFLAEAERCCDSSEFEGDVGCCPFWGSRTYGGLGDIEPFTSLIGLRVFRFMAARSLVKYYEHLQKDSVEGKNIEPKSEKKHSDGHSMQSQVGTPLELWEKAITAYPDIVEKYGQLSGELFEAMLGLEVFEGKPPDAMKEEKKNRQRSISLSGSEYGNLPADAQSIIVAGKLGKPVKTLHDPKNDLPALAEEVDQDDLELDGAVKSQPIVFEIDNERLALEKVTHSSFVAPNARLIRSMRRCDRKMLPILTDWECVDVVLTEFEVLYFETNDPRTVASKSHNDECSLLALQATGGGKGLRLQDVAKGRKIIGHMMLTDVTEIHVERSMPLSCSSQNEDISQLYDSDDQLPTELWTRSQGKSKATGCRKARWEKIKEDRLKLVSSHGCLVLRFFSDLEDVEMHSKSVAPEDEAQGPLRKNIAFQWAQTVAHVCGKEKLHQSLPHFGENNSDELRDLLEFANNHEKEHSIVLKNLKEKTVANPVKPTIRRSHSMETERFGLKGRIRRRLSLSSQGTQNFVSPKDGVVEELQSAEATEQKGLKNIDGMEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6W3</accession>
    <name>A0AAD2G6W3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6W3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="198" mass="21773" checksum="C2BEFE4819650831" modified="2024-05-29" version="1">MIIPQTIEANGPPAVISSVSLVGLESVASISSINFSNDRPQRFGNSSPSTERPIVKPARKRSTDALSLLDAYVNEGMQNATFEDDRRSELKAPKSARLERVVSSDGSSLCSSTSYRSSQSSPQDQLTDHSSQQDILMERYLMLVKDAKLKSKTNAPQMPQRKASIVRRVSSVMPLSMPVRKSSMANFTASTSRRRSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7K5</accession>
    <name>A0AAD2G7K5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7K5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051121">
        <property type="entry name" value="FAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796:SF4">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="93"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="325" mass="35232" checksum="BF1C71CE6ED2D662" modified="2024-05-29" version="1">MVRLARVEYLGETVLAAQLKDNGDYCDLSSIAKDVPAFFALLSLLSTTTSTIMMEQQQSVRDLIAGKRSDKLRIIPARHCKLLAPLDKMQVNKLIGIGMNYFDVCKELNKPIPTEPMVFSKFGSCIVGTGDPIPTCQSITQKLDYEAELGVVIGKVVPRNASLEVARQCIGGFTVVHDVSARDWQLEKNGGQWLLGKAGDGYAPIGPVIVTTDEMPLEMAQNANIQCRVNGETLQNSNTKNLVHKVDDIISFLSKFMTLYPGDVICTGTPPGVGCFRKPPRWLVPGDVVECEIDGIGTIVNPVVQLEGGSSAAEGEATTMMQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G869</accession>
    <name>A0AAD2G869_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G869"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042142691" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="25390" checksum="038A62663FB78CB3" modified="2024-05-29" version="1">MIKSLHSFIIAVIIISVVQNGSLLVKAQTPLPSCASVGVTSQFTCSTQCTEKGDALLLFRGANGSNECSCSTGGKYCDDDPSCADLLIFPGSAQQGCRSVCASGTTVQAEDSVRYATATSATPDQAYFVVSCRCSGVEQCSDSILFSDRVDLPECADVSITSQETCQAKCESYGSSLFLGFEYESKNGGEVSICSCTGANGNTAQYCEDLDRRAVVNVSGASSLFIMMAGVATSLLVVMAMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8Q6</accession>
    <name>A0AAD2G8Q6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8Q6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042008011" evidence="2">
        <location>
            <begin position="23"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="411" mass="42574" checksum="A19AFA891830CE77" modified="2024-05-29" version="1">MTRTPIRYLSLLIAIVSHSANGECVICPNGLEFPDAQIPQGDDGGTVSCTEGASIMSSYDRNSCVATQVGVIPICCPSQFQLIAKDNVCGWCKNNGGTTIETLDASFRGPLDGMGDATCADILPGIALATDTTGCSVYEYAEQYCCHNAQPGAVLDEEGTDTRGDVPANDGGGGDTVTAPPPSNCHFCNSGIEFPNARPMKGDETDCQEVANIFIQIRSALLNNEMACNSYRQLEFTCCPSSIDIPNPVGNGDEHGLADDIVPKAATDQTPPVVEVVQNGDVTIDTEVDEAVLAGVGDGNSTTTAGAREGDAGGAAPIGVIPDIAVVADLIFNNHGGSGGGGSTTNKDKNTADTTTTGTSSTSSTNKEGDGIDYDIIYPDENSGSLRHTTFGSVSMMSCGVIMTIWLLQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G907</accession>
    <name>A0AAD2G907_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G907"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="754" mass="86043" checksum="B977647C4325E2FE" modified="2024-05-29" version="1">MDFVEHDDEYFDFVYHEQPSLETIPESSSCHHSSSYNHYHHYHNHHHKYWTRVRFLKYLSILILQYAVLSVVFQYQWNLQHPPTLPPEYYQLDDDAYMHKSFLQASKPPEATLVTSDDSKKSIITTIDGTDTSSGSHLLSISTTSAKNGTTEREMVPNEADNSLPSNDSVSDVGGDGNETLVHEEPPQEEGQLRMETAKPTAKVTQPTVHENPQQKEAQLTIETAKPTAKVIQPTVHENPPQKEAQLTIETAKPTAKVIQPTVPLNLLPRTELHFYDYFSDSWLITKDNFLQLNTTAMGHPEQACFQAIRKPNFYIHPTSKMFVDWTDFMVEHMSKWWGVFRIARDDDPTMFKHVVDILDNYLMKQSSAYNDELDTSHEEISSLPPLHRTLAMIAFREYQTGLHPARGPILSSHVLAATLASLIPMGFGRILMVGYDPDDRTRVFEALEIIEASYKGAAMKHPKHSNFFSLTLGSTEFAYAKIPKEHWVKTRAYDSNVPRGALRGVQLAVQGNLTELEAHGTTIEEWLGMKYDASYWKYFYLTEPDTILHTKQELLPSMREGLDRGLSFFPHRLQPIPHEHDLPVDKIALDRRLDGRDRPSWELPYDEQQESKHHDNENSHPSRKHFSDRYAGMYLPANVPPFSNITILDSKNKPEEYHCCDGGKGWPGRSEEFGTDQNPCNGKSWWACGFVGEGRQSKSADRVQELHKRLIPYPLMSLEQGTGVIFGPTNAGRRCFPSHSPCPNREVHVLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9S6</accession>
    <name>A0AAD2G9S6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9S6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00838">
        <property type="entry name" value="MPP_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042010242" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53875" checksum="BFB5085B637B313D" modified="2024-05-29" version="1">MMKLAVALLILYGFSIDTDASSIPRGSFNVDSEVLLELPLTPSELSDRKEEIPESKSDMRLVGIEYRFTREPTKLPTSKEPSDVPSLIPSEIPSESPSEIPSDFPSVSPSTLPPSSPSPTPHPTRPPIRPFTRPPTPEPTNTPTRPPSREPTRKPTPQPTSEPTRKPSTTPPPTRRPTREPTSRPTRRPTRRPTPQPIQAQRVENDLVTRFAVIGDIPYTRDHESRLKRHVDRLASNLEFLIHVGDIRNARSGSKCTLKEYQNVASILSKSPIPVFIVPGDNEYQDCPNFSESWRNWKRVFAGFHRKWNTPFRVFQDSQRPENFYFVHKRVLYIGLNIVGGTVHSASEWRSRLSYQWRWTRGLLNTYLPSKEASSVVIIGHADPRSEHNAFFDPLKNYINDEAGNKVPFLYFNGDRHRFQRNKNYRNRSNFHRIMVEGGRKENPLRMKISVPSSRDHGKLSISDIYSYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCC7</accession>
    <name>A0AAD2GCC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAM136A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM136 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCC7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008560">
        <property type="entry name" value="DUF842_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21096">
        <property type="entry name" value="PROTEIN FAM136A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21096:SF0">
        <property type="entry name" value="PROTEIN FAM136A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05811">
        <property type="entry name" value="DUF842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17165" checksum="ED82A20A97F5F48F" modified="2024-05-29" version="1">MASASAQSRANALNQKIEAQAGLVLEDIERNYIRKIGRESFACAVKCYDKAGSSGPQEALEQCARNCQVPYQQSAALMQNEVAQFQNRMNRNMQECQEKARDMMYPGIENDARKMTQVEDALVKCMGQQVDEHIKLLKPMKERIVSALKSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD19</accession>
    <name>A0AAD2GD19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002480">
        <property type="protein sequence ID" value="CAJ1970198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="717" mass="78927" checksum="9B987E1C01D5225F" modified="2024-05-29" version="1">MTDPNSEAALQRVDNPNINDVLCGRGGSINSHAGNEHFRQLVEKRKRVYLTARFKREKRLIASSIVSEIRALDPQGRFLARKGGKDNGFWYDIGDEKARDKTSQALRENAPSIRAEIETEINEQRREMKEKDEKEQKEKGVKAPPQPPAQPQPAPSAYHHPPPPAPHGYYDPRAYWDYYYYYYHGYAPPSAHGRPPSAVPPYPHPTPQHPGHPPPGALAGLPPPPPPPPGTPIPPPPAGYPWGAPGAMPHPGAPPHSHPPQPPAPLHMNQHHPNAQHPNMTTSSSPQASSASQEDHDHEMAMTLQHQEKQAVFEDRKRRLTSDPANKLRMSVAFVSPGHLPRMQADSNDVAGAAASPSFDMSSTNKEMSQEELDHRFAVALQEQEDNELRYQIEHTDRRASRSSAFPMHGGTRNVSRNSISWLNQGAHASPAPAPGANNNSSSTFEQILPTSFMTWTKTLANGQSTQDESGQNEKHVPLGADGTYSPIHLEDSAQSQMMPPTTRHMLDSSVGSWENSNTGLMESSDGNFRVRIAHIASPKKQRANPSSPGLRIHALDNSGEGQEVELMDVRDEPGLPPLDKQFSRVGTSGFLPESMPSSNFYDGKKNGNISPTQSLDMDESGNSNLSGHGSLGGQSLCNIFAEKDATPDEIIHRVLQQVPSWERSMRSRSPLSMSDYIEEGDSMIRVRNASIEKPLAPPMEPIKDDPNEAESGMDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD52</accession>
    <name>A0AAD2GD52_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002489">
        <property type="protein sequence ID" value="CAJ1970258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD52"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="123" mass="14050" checksum="2DED9000A36DBDD4" modified="2024-05-29" version="1" fragment="single">NGGLGVNHIGQWLGVSHRVGPMMTYWVLPKSGIPISVNTVQMVTNAEQQTDSIKQQMQRWTADVSKIVDAKSTYINWGKEDIPHQKMFDFDDEDDEFMRNFGMLIQMKATVLLHTHAMVCVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDQ0</accession>
    <name>A0AAD2GDQ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Copia protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002514">
        <property type="protein sequence ID" value="CAJ1970432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10999" checksum="478582960B7DCD28" modified="2024-05-29" version="1">MFMEEQGYPIEKNILYQDNMSSILLKKNGRSSAGKRSRALNIRYFFVTDQVEKGNLTIEHMPTDDMWGDYMTKPLQGEKFRKFRELIQGDQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGB4</accession>
    <name>A0AAD2JGB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS10752</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="860"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="964"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="990"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1020"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="106"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="779"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1220"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1946616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1243" mass="138945" checksum="8FEA46E34AA1A5FB" modified="2024-05-29" version="1">MNESATTETVVSAATTATFTALGYNAAFCSLIATCAMIAFSAAVHFGKNGQLAPRTWSRPKEVLKNVLSRPYGLSWIPWTLNLTYHEMLEGIPGTGTRNKGKQGTLLKCNLDGIIIIKFHSLMLKVAFLTSILCCVIILPLNLTAPCNITDSGAEVCKNITHMDNYAMTTIAHIPPMVFVDEAVLPNATDTRGGFRLEPFFQNLNRYFVNDSGITPRLICIVIVAWCIYTYTCYLVWNEWIENSALRRIYFLEAEHFDHRKQELEYLANLDVEYERPEMNLKQFLPHPELRETVPPVSLYSALYKLPPCDVISVDEQLKATIEFFDKCVPNQPGFSSSVAAATILPDPAHLALVWGKFYALSTQVRRLRFIRFRLKELRSERRENIHNISVQKLAELNGDQEQGTSPMKKVNSDGSISARKKKDARSNPKGLSVRTSFIDPDDPDDLFGYNNFQLDDLHMEENIESLAVFEREFSQSAACCPNGMCNDSRIRYADVDTLLEMEEETQDAVDKARRELIAARSSQKRSSTFRAAVRENFEMLELEEMDAVTPLPLPTNRRFSQAREVVSLGQDLDASIARKRRSNTDFSNRADSGSNPFEDLKPNLSGESGVSGIETVDASYPTTHRLWELANRVVLNSERPWSVGRRRYRRIADGRWKWTSFYSWWNDVALVEENPGEFERFGGVAKNAKPSTKKVINSLIEQQKYAVVTFTSRQAAVSARQCVADASGLDRWVEIDSIPVPPLADSPPNNILFCRGCCKPVTVTLNDTSKKARNNLTIMTLIFFCLLYTVPLSLTSTYFSDTAQEAWPNFPHHNLLSGFISGGLYTIFFSVCPFIFKLFANYGSNATSIRQAELGALRYYWFFILFTAFAGQSLVSMTINGYLSTSALGNQASVVVMHVAKTIPTSQSVIWMNWIIIRIGFTLPVNYLLQFNTFLFKNWPGMRCCSRLVSGGGAGGPMPYRMYVDAGLVFLCVIALAPASPLVAPIGTVYFLVSTPILRWLLIFVYRPMYDGGGMRWTFLHDMIISAMVTSQVLLLAMMLLKNAHGPALLAGLAVVPTLTFNNFAKKRFLRPYSDAGLLQTSQLDGWDYVKLSSYDSREEFRKWLVDCHKASFIPMCLAGKDNFFSYEPAVALPDDYQSPRKSPGAVLSPKASAEDLSNSVGSLSDFQSLGSSRMDALTKEQMAQKGAMFRRMSLSGRGSFVNPQTFFDGDLFVSAGESDSEIGLGPPHTISDLGLGSPHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGL6</accession>
    <name>A0AAD2JGL6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGL6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="354" mass="38429" checksum="BA8C8BE35C6F4F32" modified="2024-05-29" version="1">MEESAADGNKEATKSSSDVSDQPTPVQRTANDILCGRGVPILNYHGNIRLHNIIDSYRGSYLKSDRKEKPVLVRQIVREIKAGGARFLKRSSGNDSDSWVEVSDSYAHEKVSHALRCKKAAAKSGSTSTSASAIKASLAGPSSGGAQVQQPQEAPPNIFQTMQLSSAFPSLRGSFQQPFQQSQLQYRQNPFAYALPPSLLAIDPSIERTNALSRLTSPRLELASQMEAARNPFAYLNSNMNSNVPSFGYENIFPPNPALAGLTRSTVDSLSTSIRQQRELLQRQMLFAQALPSTAQTSANTPNEQMQALQRLRQAHALGQNPIVPTQQGLVHTISRKDTTADGSPGKDKVKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHI5</accession>
    <name>A0AAD2JHI5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001791">
        <property type="protein sequence ID" value="CAJ1951627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="395" mass="44474" checksum="380DB794A25B757E" modified="2024-05-29" version="1">MGHLDRGAESLGARILGVVSKSGSIVPGPINVGLELLVEKKKEKRKAPNRSELANGLCSLSTRVYVELAEVFINSTAFHCFTIGKSTSLKVVSTTANKAGGSTPKSVSVAKKRGKKRLENASAVDLRQPKDRDPSVNNESEIQELIASLPPLIDFGLSTHHLIAIGYNYNSTKILFGNSIFNQWMENHNDRWTQALPRFDSQFKDLYANYSVEVRVNMLFAQYANDWRRVLKFLISLFDDDALGKVEKNTEYTWGVRAIALQVAQQIPFSFFDVGLVNDSKVPQEDLYFLRDDRSNPALRNETPLVQFWLMCASIFDHPWTMLFDEFLEESPISCIQEIKLKVIEGFPNDETSKVDIHKGVKKIFDRDYEDSEEEDDPMGDEDTGLVNKIGQPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHP1</accession>
    <name>A0AAD2JHP1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="241" mass="27558" checksum="0D69BF3F7C255967" modified="2024-05-29" version="1">MPHRRMIQQRQVESRSSTCTLMDMDDMKTAISTPADEPSLPNLIPDDLSLSSDYYESEDEEMVVTRKVTFKSSLKMRKIASHRKYSKQERAATWYSAEEYKKLRDSASRTAKRMARGYSVDKDGKESSRGLEHRIAESHKIRQTKRLDIIWTVLGEQEEMFENGEEVDHEQIAQIYSMCAKDCVAEARKRGIEDELAVRVPKAPALPSSNDPVFTNTKKADDIMSLVASLSMKAAMTVQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI77</accession>
    <name>A0AAD2JI77_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="438" mass="50766" checksum="90B5F88A08D4EE9F" modified="2024-05-29" version="1">MIFSMIYASRSEENERIQLPIDTNSTLASNIRNIWHFPSKQAICIELQNNTRCRRPAFLGRLSGQSLALLDWKNQNDERFGPFKRCGSYGGQWLSNGTYFLEVITLFCEDFGINSLTKSQNESEWLSIDFKHKCMEDPNYNRVTHGADSHIQIRQQVIPPSHYVPRGRWVLPTAESPPKPIHYRYQPIGCRENPKTARCENATDVYRLRAYSYEWEDNAGEVWREQVQNVKSGSRSFPTVCFVGYSHSRITKESFVRLGLPKQYAIHVKVKWPEDITAALFNQSYVEQGCKVYIIAAAQWPGSRIDRFPYLFDRFYAVMKQIVETATSVFAGRDDDVRVYMRSIHEIPLGDFTGSCPIVDWRSPIVMNGYSYLVEKAVREVQEKNDTSNRLIRYLDTSFLVSPMWDSATDWVHLPFQVSDEEALYMASVVSNNLLDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIH1</accession>
    <name>A0AAD2JIH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="941"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1149" mass="129493" checksum="C61BD718DB596474" modified="2024-05-29" version="1">MTTHDDNSPRRKSRQGQDNGLSLTAGDALNHDHGTPPIMMHHRPSLLAPSTLRQVTRVSKRAALATKKQIWDSNDASIVAAQSAVDQWEQLYNALRGLLNVTGASAGGLYGAAKAGANGLEHGLLVPVRDWVLLPAFGGVEHIAVETIGFLQSEQCRALERAGLGVIQQVPYVGDNILAPAVCKGAEILKQSWKIAQYPIPSPSQVRDSVEFVMTGTKWCLSKSSQEIMLYAKRADANITRTISHTQWKVLGSGPYATLNKLNKSEVLDHICERYFSLDGIVARYELAAHIRTYNRHLYHDLVLTGLLRERGGQLTIDDEWLSSSPKYRESECSFLLQRNDDDDDEKSVDKTLFPEVIPLWFRLPNYNGQRPSKDTPWKQFSQKEGSLLEEFFLSSLEKMKGNEDKIKLIEFAKNHNAEINDETRPASTKYKTQAHWYDVDVENDLLLDQKRYAVSAFPCHREPGVSDALELPPPLTFLMRPTLWRFHGLGDEVRRAVWFLDTKRHGLQPYGEGAQAVLEDAYMFLKWTTKQPKEDGGIVLTVEVPSPDESEYQLVQFSSLTSATAIGKGLKGAMSLFKRRVYRGAYQEVNSDFEDDVAEDTGLLENATNAMDDYDPDLLMLPDIEEDEAEQEQDQVFVFQDCIPDPSFLRPDFESKQKKGKRESVDKAQLEGENDISDETVYESASLAFPLEDLNARAEDSSNAMQDEGPIEHLVLVVHGIGEMMINVDIFGLSKMPTIVDCCDFLRHNHAEVLNTRYSRRGRVEYLPIEWHEAFSIETKRRSLGPGLTEQTESIFTINDVALPTIPQLRQFANDTLMDVLYFMSPEHHDIIIDIVVNEMNFVVERFKRLTGFTGDTSVVGHSLGSIITWDILENQRVTNANAPGDRLAQMLHNVPERTISPSQVHSGSSATDCALKNDPESVSPLVEDTEQRLSNYPQLSFSVDNAFMLGSPIAVFLMIRNPRKPLSSDYTLGGCSQIFNIFHPYDPVAYRIEPLLDSRNAEIEPRIMSHWHGGYRFQYQTKRLWRRIVSETLKTQETVLEGLESGFAALGLLHVSNDDSDEEEEIDAVYHDDPQVEMGSLNRGQRIDHMLQEKEIESANEYVAALAAHSSYWVEKDLSLFIAHQICLRSLECETCDDIAFAKDETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIM0</accession>
    <name>A0AAD2JIM0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001855">
        <property type="protein sequence ID" value="CAJ1954067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="11172" checksum="F9938E5C7FBDDCDC" modified="2024-05-29" version="1">MAQNKIFYSAKLNKNMRRSAYFETNKRTVKSNIMLKFVTKAMDINLQGEADFTTTLEDPIKLLKRIERFMKKSADAEYDFLDFWEANQKFLAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJY8</accession>
    <name>A0AAD2JJY8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJY8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="188" mass="21054" checksum="1848768B50743A6E" modified="2024-05-29" version="1">MPMPLPTDPFKAHQRVDWDAATPFVSDAFPLLSAPPPPRMRPRPNPSDIVECRPTDIERLSLPVLTMDDQPIGPSETPPLTLKILPRRSRPYSEFSRRRGVCGKRTRTTDEKRYEESIFKSATLQYSGISGKTIYADPVVTSKEMTGDIKSSSFGSKTGSDEDSFYVPTPRFTLTTRSALPHVLRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL19</accession>
    <name>A0AAD2JL19_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="114" mass="12100" checksum="770AE37B4D72C96B" modified="2024-05-29" version="1">MEASLGLATTDISANQNKTDNDGGEDTTTSSSSQPMDYCASTIAPPAITIPVAALSKVTPVAAPLTKEQLQSIPRKHDIVCKCGCIPAIPSMFQMAELRKQAAREKKNKAKQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLF9</accession>
    <name>A0AAD2JLF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="348" mass="39172" checksum="190F29D4A181E9FA" modified="2024-05-29" version="1">MKFLENEKLIELTGQLSEATLGQSHRVINGRIEAYTMKRAGNDKKFAHTLGQKFIADLEEQQQLLHDLTQMAAGQKAATNADGTSTSTTTTTGTITSLQRLQQQSQSSSKPNEKPKQKRKRSNSATSFLETISKKKPKTSGRTRSQSVDITLHTNRNTLGDISELATRRLMTDLILTLNASFPDYDFSNAKPQQFEKLSLARVQRSISERLSELATLKKLDATGKLPTNASTVDLVVEIFSALDSVVSLKECDFYSFEDESFLDESDHLWSFHYFFVNKSLRRLVFFTCSEHIDFREEDHHASEETEPEIMMPSESQMLENTEFDYSNTPGDAVFSGSGMSMPVFSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMC3</accession>
    <name>A0AAD2JMC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS20576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000050">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="422"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1964325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="789" mass="91149" checksum="9D2A4613D7212836" modified="2024-05-29" version="1">MPRSKALMKKRAGNGAAPKKIVIKPFSKPPALPENYYEKTSRELLDGTLNIIFNPSAQQLSLQNSYQQVVNLVSHKFGPRLYGDLIKTFQKACEVYVLPRAETSQLLSYIQTQYQRYVDYLLLCKHVFLPLDRTHALTVEGEIVKRAAGENASSNGGQLNHHHHHPTNASATMGLWQVGLEQFRMRLQQFQLDDQIYQRWWEDLQLDWDGNLGLEQQTLLQRTLYMWQDLAMLADILPKRLEPDLIQFFQAKAEEMKSDSYSANAAIAYCHSKWMHVAYTWSRFLPKSTCVTLLENNLFRPHLNDEWLLKPSNFDPLVEETKSAVAASPTAIQQLWMLCGRLPGGYKIIAGAVSKYAKTRGLAMMKSIGDSKVGKQKIAELLQLQSELSTLISSLPHGAEHCSLKHVWEDVVNPPEDNDTNVVAEALAKYVDVHMKDAKKQQPDSNWASKIISGVFCYLQAKDIFEAFYKKDLAKRLLWNRIVSMDVERNFVSLLKAECGAGYTAKMEGMFQDMDWSRETMTRYKQSTFSDGPTDQLDMDIQVLTTGYWPVYPQYPNLILPQNLKDKQEHFLDYYRTKYQGRRMTWQYFLGHVSVQFRPKDNGPKYSLLVSLCQALVLVQFNNGNDMKLPQLMAAIGLEDRQELERILQSLSMGKEGTRVLQKRDSDASEKKKKRMSVHDDDTFRINTGFKSNQRRIRITNILMKETKEEREKTVEGVSRDRLYLIDAVLVRIMKARKTILHQHLIPQVLEQVKVPAQPTDVKKRIESLIEREYMERDPKDRNRYNYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMC8</accession>
    <name>A0AAD2JMC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS20574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMC8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="302"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1964321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="434" mass="48882" checksum="5808DF0854AECC46" modified="2024-05-29" version="1">MGILYHFLSTLNCVNRRPSLRIRPWENTMWLPPAERNLRSLKETAITQKSFFFGALQCALLREQWILARRIYNECKRGGFSSGRIISLYAPWKWPLSKWKDSILPFIARHQATLWTMSFYKFLASTFCSEATVLQLSQHPYHRVKSLASKDSGPLSIAANAFVITVWSNLLFYLADLTVGQVSLGMAQRKEYKWAVIRKDTETEEKCLQTWVKSSWKMLCQQSLRYWYSCFGSAIGSMVLPGWGTLAGVGLGEEWSNHQETPISPPPLLLKVFPRLQKYFATARSKQSSQEEFKVQANALLCGCCQANYFSSNFNHPTHIPISSKSCEHTICRSCVDLCQVAELLESGVSGIAFSEQLAPCPICNAPAAFSPQDLLVNKSLCNAIALLEQSRNPGSLSEPSSIEIDLGTLKKFRRLSYESSMSDDAHSLDTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUD8</accession>
    <name>A0AAD2PUD8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042039013" evidence="2">
        <location>
            <begin position="18"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="546" mass="59182" checksum="0EEA6083530FBCE9" modified="2024-05-29" version="1">MMRTSVFALSALSLATAESTLSLRRRLSFEKVAGYAPGSQVTDHCAIDRDQAEIETLLAKKTNEAFSSAKAVYNNGGNSKSYARVTLTPALVGPLAKGARITGKSTDGIEIAGKAYNSYDAGAKEIWVQYATTDIQASYVACQVGSLVESINTEGCFAAEGDFDISGTQYAYTYNIASDNKNGRTIAGFSTEAGQKMRLDCPGCPYTDFTYFYNYYGADDYADEWVNAALDGGSTTFKNGNADFSKYGFDGRVEAVKKGTAYLNIFMYVIREFEDALDDCKRGCMDCNDDPVHAWDEGVCFYTGSIEGKDGLTPDGKLLHQLADKRCADFKTCGLESGELDGTANLNYELFDLFSLGKFQLQTGNCPAARKTTKLVTELMYIPMIQGTLRYAYKVGVLNEGEKAEAEGAAFAAAVLPRIHAANQDAAKTIYENMKVGASNTDHMAVKRAFESVYANLGITCADVGGLWNTATSSYYDGYEPCTDASTGGVIKEEDTTLAVIFGATFGGLFGLALLALCFKRNKEKRGQPVFSPTMYEEEDKPTELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW05</accession>
    <name>A0AAD2PW05_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="821" mass="90778" checksum="A85FFB16ADFD6526" modified="2024-05-29" version="1">MATWTHFFSESDQVNKQEASIFRSNSFAAPTTTAATAASAVVSPANIHPLAESVLLRSLSAEMSSSAAPAPANPAPVATNRAPNPIPRRNLMEAFEELHIQPPGTDVEGVTLQKSLSIKGEEESQPPAISPTGVTDLVQNAPKQGTTESKLLQPTAIITPDKTESISGLVPTFYLHPELKRELSDALVNRVSFYAVIHDINKEATAMAASDDSGYNRNPEDMHEEYDPLVVAVNGPPDENFVSNNSFMQVALIDEERWLLDTIEARSNEETRWLNACPPTFLQAMGERDYENPLASLSNGSRTQLWKPSRSWWEAKSGKNPWIEPKSHNKRWRYLWPLIHYHKFLARCIKKLKRNGVDVKTSVSPVSVFLREEVCAVSDHLASVSLFDSDEWMQCLEYFNGWVASDRESEVRLRDLVSSLSLRPLMEPGDIDSPLLRNQIDEQYLRAMASSRSQMAGAETKERQPRALKGIVSAKQRKGRDDSKIQNYDFSGPKYRQGDGHPPVYPRQGVSPNPRPPLHAAGMSPANALPRHLWGYQTQPNHWWGNNWGNGVFVGEDGGIHGGFAGDGIPQHFEMNQFGGPMQQQAYYPPFMYPQHPQAQVPFDPNLQDPASVYGFNGPDQWIQHPMNNPAAREVQMPGTPGHMNLTQEIHANSSHADANAQMNVEQTPFKYNAHQVPMSPYWGHLDHATLAMMGIATPQTATASPQTPARTVPSSPDDKTSLAEGGYTMNAQPLLLRQQYYGYNGYGAREGYGPPSPATQFMMSPQNNFAYNYGYGNSQQVGMPSQAEEFNDSSESATETVASKSPSRNASTASKSDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW31</accession>
    <name>A0AAD2PW31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS17556</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Microtubule organizing center</location>
            <location evidence="11">Centrosome</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus end of microtubules and to the centrosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="395"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1959132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="429" mass="48185" checksum="F963F7A3C5299C48" modified="2024-05-29" version="1">MVLTDRQRQDLHAGIYEYLLSKEEFKECAEAFAKADPKCGEKKTNNVGKTPLLEKKWTAIPRLQKKVLELERTVAQSAKIHAHRTGEADANGVQRRMLPRLPCTETLQGHQGPVFCVQVHPIFTVAVSGSEDGTIKIWDHESGDYMKTLKGHTNAVTSLCFTPQGSYLASSSQDLSIKIWEFETYNCVRTLRGHDHTISSVVFIPAQNVIPTTGDDNAAIDVTLAESRQLISASRDQTVKMWDLETGFCDHTFTDHSDWVRTLAIRQHDGNVWASAGHDQVIFVYDNAKKKIAELRGHEQIIESIAFLSEDNFPKNVNPSRVETQRDYLVSGSRDRTVRLWSIANASCLQVFSAHENWVKSVLIHPSGNYIISAGDDRTIRVFDIKANRCLRTLEDAHSHFVSSLDMHHTLPILVSGGVDNVVKTWVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWD3</accession>
    <name>A0AAD2PWD3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWD3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041939425" evidence="1">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="237" mass="25707" checksum="642FB6D49C24B61A" modified="2024-05-29" version="1">MTSFQSLFLLSWLIGSVFGFQSLLPHSKKISCGQSTSTTKLSEIQGDPLRDATGIRPSLHPTTINAISNALKARAMKKEGAHFQASDTVEPLEVAVTAGLFASEAVALRQKSSEGDGMTLAPEEEQTIAGRVVGVVMRFDTLESLLHEKVSNVGWIAKYDEWATFGTLKDESEEGAVDNRIKDDPLFCVSRAECLLALFLDTVEAPTMAKVGQTVPDQSKIDFLDADRIEVLVSSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXN5</accession>
    <name>A0AAD2PXN5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002292">
        <property type="protein sequence ID" value="CAJ1966523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXN5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="512" mass="57752" checksum="FB87B2E50CEA8C0A" modified="2024-05-29" version="1">MQFAKAHSLIPDRQCGSRKRHQAIDLALSKQLVWDLLILQRRAAGWISNDAKSCFDRVVHWVAIVTMLRFGLTWRVLSSMFNMLSSATHRVRTGFGDSKRSFRPPSAVPFQGCGQGNGAGPPIWISVSSVLITMMEAMGYGFECLSALESQLVTAQCFCFVDNTDVIEAGDTVHHSGEDICASVQAAATLWSGGIRATGGAINPEKSFWWLIDFEWDACNGQWRFRRKCSAAPEFDLKIPGLYGDIEPLCCLEPDDSERTLGVMLSPLENHKAQEAQLVSKAKAWAEQLLPHLLHKYDVLPLIRTTIMKKLEYPMALTTLNAQQWQEIMSPVLQVCLPKSGVCRNFPRSVVFAPVDYQGLGVPHPFGKQVYKHLEMILRHMSGGTKTGAYMDANLQAHQLETGTSFGLLQQDYQNTSILASDTWLKRVWKELESLDMYMAFDSPALSLRCHHDALLIDLFMDLEVDQDDLLWLNWCRMFLQVATVSDITTADGRYIRQCIWNGFRDDTYRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CB97</accession>
    <name>A0AAD2CB97_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1921004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CB97"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1921004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="312" mass="35600" checksum="46B9F263FC296749" modified="2024-05-29" version="1">MAPITSEGNKDFEKLVLIAQGNKALSAHTVLSKYDIQSEDDFTNALSSLVPHPIALAFQSNRRNTEGPECNQHVRFRLWMCRFIRDYAKIMLLDSVGILHTKIEMDKLVGKRKSQRQLNRFWSSHADTCILCDRGVMKKYGASFGWKKCTECKGWVCPYCDCQNYHLFHQAKLLGVSLETGKCKPQYKKIADMRTGKPNKERQVAPISTMTKHLSPAQVAQEIKKTLSPCSVISASSNDRQTPHLEARQDATIEQDCTSVKRNEPFEERVNFVQYLQETNSMIALANLMDGLELQGYDFERESFNCTFVDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCZ5</accession>
    <name>A0AAD2CCZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS1894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005543">
        <property type="entry name" value="PRK07206.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13535">
        <property type="entry name" value="ATP-grasp_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="134"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="625"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1930298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="953" mass="105500" checksum="752A3AFFE8C3AFD3" modified="2024-05-29" version="1">MAAPQIMEEESPYMKERKCVVLVDPYSTGCIVAQEMAKRGYLLVALWTIGFSDEMKTHIPESCGHMDYFAQVNQQETLEETDKVLKAAVGTHPVEACLAGGEAGVDFADAFSEYLGLLTNGTDIPNRRDKKLQQELIKKAGLRSVRQAGGSSFAEVESFLKTEPYPVVLKPVESAGSDGVKLCYSIEEAKEHFDVLMKSQMVNGGACPSVLCQEFLKGKEYVIDHVSLNGEHKTCMVWVYDKRPANGSAFVYFGMLPIPIDSPEAKILVNYTRRTLDSMGLKNGPSHGEVMMTEDGPCLVEMNCRAHGGDGNWRSLCRALTGGFSQVEGTVDAYLDPFSFAKTPSLPPSPYKAFGQEVILVSYSAGKVKSTPGFDVIRQLPSFVCFESGIKEGSEVDYTVDLLTGIGSVILMHKDEAVIQKDIEFIRYLEKINGLFLFETKAENLQRPRGDLLAMDQITNSTGQQGKPRNHRRVFSSDGPLLIRHMSNDRPELRGPLVKRMTTVDSSKEVVIIVDPYSTGCCVAQEIMKRGFSVMALWTKNFAPEMKTHVPLSCGVMKYYNEIDEAETLDDTVQIVHQAADQKRVVACLAGGEAGVDLADALSEKLGVRTNGTSIPNRRDKKLQQELIRKYGLRSVRQAAGVKFEEVEPFLTTERYPLVLKPVESAGSDGVKLCHSLEEAKEHFHVLMKSQMVNGGDCPAVLCQEFLRGKEYVVDHVSRDGVHKAVMIWVYDKRPMHGSAFVYFGCIPVDSDSSEAKILIPYVRGVLDAMEITDGPTHCEVMMTPEGPCLVEMNCRAHGGDGNWRSLCRALTGGYSQVETTVDAYLEKQEFARTPDKPPSPFKAHGQEVILVSYSRGTVKATPGFEEIKTLQSFVYLETGVKPGSVVDYTIDLFTGIGSVILVHHDQETLENDIQRIREMEKENQLFVLENQPGFLMKSPSYLHFDGTTTASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF50</accession>
    <name>A0AAD2CF50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="3">
        <location>
            <begin position="233"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1932796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="362" mass="40038" checksum="52EA7E2C8424C119" modified="2024-05-29" version="1">MVSESDEDAARRDEEWGALIAFYGDDLVSGGSTLTTQTPTSMIPDELSKTAKGSSFRYWNIQVMPPNVTLELGDIPRDYPSGPNPPKPKLKAPQWIMDETRQEELEHELLTLFQSDTEVAIMWVEHCRSAIEEYQEANQAFSSNNDSQQADHHDAEGDEDPTTTIADNNNTNDDGSYEPPASSVTISFVPGSKFGQSIRHFQLSVVDNPAYQREVFHGAPFHPPKSGPSETMQSHVASVSCMEHVDWVLHHLLFDVKKVDQASHNMIAYRFTDQATGRLVSDSDDDGEKGSGSKLASLLELTGVEDCIVVVSRWYGGVHLGPARFKWIAAVGRQGLEDAGFLKKIKDEDSSTTSKHKKGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFP0</accession>
    <name>A0AAD2CFP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidylprolyl isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042271891" description="Peptidylprolyl isomerase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="749"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="829" mass="86416" checksum="DF8D3D7E3E2EC908" modified="2024-05-29" version="1">MMRTSTILLFLALFCTAEAQNNGTCNPIKDETSCSSAGCFFCPSSSKCRVAESNCPGGGGGNNGGGGGGTEEEEDNEEQMPIVSNGTCNPIKDQTACETQGCFFCDKQQCRVSEDRCPNASDEGTCNPIQDQAFCEEIGCFYCAEAMKCRVSEERCPAPDEDEETDADGDEPVGDGSVTNGLCNPIKAQGSCEESGCFFCTNKSKCRISEQRCPGFNGVANGLEDNIKCNPIRDATACEDAGCFFCEDKGLCRATEAKCPPGAGTAFGSSECKTFKGDETGCSDAGCFFCGGSSAQCRLDEAECPGQGRSSPCNGLEETGCSTSEDCLWCAEGNVCTSARGGTCASAGLPPGNLCKQYTTDADCTSGETSNCRWCPGNLKCKNAEDECDDGEEGIRGNPCKDQSTTDGCTGVEGCLWCEGNSKCKKAEDGCDDEDEDGDADEDVNVGAVDCTTLIFGPDCEAEASCLWCPDEQTCNAADIFLCGVASATVRMDIEYGSPAFKLKNEGLGESDPNAVEVALNYYFEVAEDGSEIPFSFVDVQNQGFKVSQSQGVFLGVLSRKATFSADIVGVGSMELIVYKILEDGTITTPSGEVFDVTEGDVKFNVNLSNWSFCDEDETGICADSGSAAYVDIAMTVKGSAEAPEQDEADGSIFDLGGGVPILLTNQVEIDGVIDAMPPGFPRVEQTPAEGAFFVFRFPRFANTLVYDPIVGSGTLIVIEDATLPPVTPPTDAPVTTPTNPPPVPAPTDAPATTPSVPSPVVAPTDAPATTPTDAPVVAPPTDAPVTTPTTTPVTAPTTAPPGGDSGANTLALLMPLAVCLAAFWSSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFW5</accession>
    <name>A0AAD2CFW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS99</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1892547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="120"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1892547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="209" mass="22507" checksum="26199A85F362FF6C" modified="2024-05-29" version="1">MPESSWIAPNPPPVTLENPQFQLNSYLDTLDPSSFEEDTPAAGGASNKTKILQDEILNVTEFLYGNNTLMAALALLDSSTAAIPSIVKISSPRTCGLTRSVHVVHSSSKGRALGEDSSSYLCFTQANNGVDYCSCRSFLEKVSKSSKSTKDVTLCKHLLALKLAPYLKVDFLETHLASHQDFSKLILERTLPASGIAPRGSNGIPYSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGD1</accession>
    <name>A0AAD2CGD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000193">
        <property type="protein sequence ID" value="CAJ1931987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17814" checksum="59D9F64D0ED34627" modified="2024-05-29" version="1">MKWMIDASFAVHPDFKSHTGGTLSFGGGAAQVMSKKQKRNSRSSTEAELIAVDNVVMMILWMKLFMEWQGYPIEKNILYQDNKSAILLEENGRKSMGKRSRAINIRYFFITDQVEKGNVKIKYCPTDDMIADFMTKLLQGEKFCKFRDLILGPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIK1</accession>
    <name>A0AAD2CIK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS1793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000102">
        <property type="protein sequence ID" value="CAJ1929913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042078688" description="Helicase-associated domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="3">
        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="3">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="3">
        <location>
            <begin position="225"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="3">
        <location>
            <begin position="296"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="3">
        <location>
            <begin position="366"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="3">
        <location>
            <begin position="434"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="3">
        <location>
            <begin position="505"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="3">
        <location>
            <begin position="575"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="3">
        <location>
            <begin position="648"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1929913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="721" mass="86884" checksum="D69A0B0EDA5F06F5" modified="2024-05-29" version="1">MASALPFLLQLGLTAAFQPGSVHTILSDDRQQTSHYSSPTRMMIPQRGSHNHRLSIYQRSATASDETEDSLIDEEKQVSSQYDWDEQFEILQSFKEEYGHCNFPQNNAPAVELENQYPTLAKFCQDQRGESKKKLSSPQRRRLEELGFEFNSQCARWYDTYHQLIQYRNDNGHLRVRNKENSKLYRWCKTQCGRRKGTKGYSKISNAQIELLDNIGFEWDPKLEHDELWMKTYKELVDFRNKHGHLLVESDGKLALWMNMQRWRCAGNSYRCSPLSDEQIGLLNEIEFPWQPERHDMKWHAKYKELEGFQKEYGHCRPSTLQDRPLYEWSKAQRKKRHKGSLSTQQIQMLDKINFSWESKRGNRANMLAELNSYYNQHGHLQVREDEYPGLYEWTRLQRKRYHGIIEKQPMPDKQIDEMEAVNFCWSLDWKEWVWREKYSEAAEFYKEHGHVRVQEKENPSLYNWIATQGKRYEGTKGQKPLSDEELELLEQIDFAFFEKQPPMSWNMMYAKLERYREENDGQFPTHQDDPELNRWMRQQRKRLRCEYGYVALLDEQMTMLESIDFPMLPIGKHRRVWYEKYDELVEFREQHGHFLVDQSRNPGLSKWIAKLRTIYTGRTPPTYRPLFISEQYLLDRIGFPWISDRYEVEWQMMYKELVQFQQEHGHMQVTIVEYPALYAWISFQRERYKKLDLSSMPQHQIEQLNKIGFRWRAIDEVNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIY5</accession>
    <name>A0AAD2CIY5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS4687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000458">
        <property type="protein sequence ID" value="CAJ1935352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIY5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="584"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1935352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1218" mass="137304" checksum="0205B358ADB71BFA" modified="2024-05-29" version="1">MILLDLIGPNDIPAKNRDKSSPTKVRVQYKQNDPTQEETLTNLRKQRFSMIPSFLQSAASSEKMRHLDSTSLDLDDHEDLRAGTRKIKSVSNNSDTDEESSAAKRDEVQEIRNRSRNADRHVQLWRSALLSLISVIGTAVCGLTFHFLHLEEQKALNLAYDQFSEALAETAIRQQQDISEGFRTFATIISDYAAATNQTWPFVHLPKFGAYAEHILKISGAEATVLFPLVTKENKQTYLKYADNNYEQIVYEAHMIENGNLDDLNPVGYKSFFTVGSKTGFVEDIDREVYFPLGHFSPPMFSYGAFNWNVASVPDYANIVEAIKVLKHTEPLISKVRPYATAELTLSNEEHAAMHSEIEGSSTEFPHSFVFTPVYLDSEDTDSPIVAVIGSPMAWDFSFQNLLPESVIGIHAILKNSCGQSFNYEINGPDAFYLGEGDMQHAGLVEHERFVNLALHTHPDFEAIQGHCMYSMHLYPDNKFANLYLTPVPLLYTVCIAGSFAFMIAVFFVYNSFVHKRNETLVANAARSNAVITSLFPDNIRNKIIGDESYRKNPRNFHELLDPTSDPLTDLSRPPLADYFATTTVMFADICGFTAWSSVREPSQVFTLLETVYGEFDRLTKHSKVFKVETVGDCYVAATGIPTYRKDHAVLMVKYAHKISCAMKHMAQTLETKLGPDTADLLLRIGIHSGPVTAGVIRGEKARFQLFGDTMNVAARVESTGAAGRIHVSLDTADHLRKCQKGHWLVKREGTIIAKGKGDLQTYWIGQSARNSTGTGSDTVSTSDRSNTSFEESFHATFGNQPDDTCDREDRLVDWNVTVFTDILKQIVARRNAYAAAKKDSNDLSAVDLGIVEDMKKDDFKPLHDVRETIWLPEFDQAVEDSQEDAHTIDIPTSVSTQLRDFISTIASLYRCNSFHNFEHASHVTMSVIKLLSRIIAPTDFEMMENENESDDDSFHVKANLHDHTYGITSDPLTQFACAFAALIHDVDHEGVTNAQLVKEGAVVAAKYENRSVAEQNSFVLSWNLFMSDRFATLREHLCATPAEIIRFRELAVNAVMATDIVDKDLKNLRNNRWDKAFKNQGNIEELDNESRESINRKATIVIEHLIQASDVSHTMQHWHVYRKWNERLFHEMHAAYVQGRSDSDPALTWYKGEMGFFDFYIIPLAKKLESCGVFGKSSDEFLNYARSNREEWEIRGEEIVAEMVASLKKRPATNSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJW4</accession>
    <name>A0AAD2CJW4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJW4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="392" mass="44513" checksum="20D3AA70B79A29F3" modified="2024-05-29" version="1">MDEESQPAFHPSSRDANDRRVGSRRNVVYEQRTASIRMDSHPNAEDIDPRKMVMLPALAEDYYSAELEVFGWDGVLKTVLSGTRDRQSALKKLREHETTIVRELYTYISNQYARNVKLTIPAALVGQSVWFTRMRFNHGRLGDKWRRRDLLEDTSGTSKGFDDGFVSFSRCGHVDFPPPANRNVNMLPFIFGNKESLLDDLECYHSLIEQCPYMSEEIGKVGYLTVHESYVDATKAQRREGLHIESPGVFQDAPDKASFEPAVEHPWGAGMFYGPDRYEGGIFMASSVSNTSEVWDALVNKNCPGIVDKHGGCEHLRPIIGKGTKLRGGELIWMTDCTPHEALPQETSGYRQFFRVVSSNVSHWYEDHSTLNPKVDLPARVKVVEGNKFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKF5</accession>
    <name>A0AAD2CKF5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000591">
        <property type="protein sequence ID" value="CAJ1937049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="357" mass="39678" checksum="322D8ECC5569E430" modified="2024-05-29" version="1">MCGKPILEGVEVCQDYLFNNLLPLAGDHGLEHNRKGGSSGKIKLDSQPTICLLKRPGKFPVRRRAMILIALNTPKVTGLLGLYMKAGEAGRIVASWIYPTPQYGGSLSLSSGAALEVLNKSKVLQRLPACRVIAAMICHDYNNNQANQIGTVIREAARKLLDEWQHCVFMSQIGGARATNHHKRRHNRNRRPLIHMATHAFHTLVAHPVGAHRDVFANNGTDCIENKLILVSSDWSPRKGNHLVSRGRGGLPSFFTFAILDWDGPSVRRRRRYEALGGREDRITHRNPDTFGELITTHLTELQQMWWNSMNENQQEAYVEGLAIPGMVPPPLGNVEVPAPGGPEGFNNWLHGIQQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKR7</accession>
    <name>A0AAD2CKR7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKR7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="176" mass="19500" checksum="EBE6C0E29445B0F1" modified="2024-05-29" version="1">MADDQRVSSLSETQDIILCTLMIFSGVLSVFGSSTIVYRVLKNPTGTNSYVRIMLGLSFFDIVASIAFILTPFMLPAETSHRVWASGTAVTCSFLGWMTQPTFGVPFDLYREVRLGMRDSVNLHFYCSVVESLPRDSPPCFCLNLKDMAAGLRMFRETVGLKVAALDRPSVGFTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLV2</accession>
    <name>A0AAD2CLV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone acetyl transferase HAT1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS1148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1925484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLV2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="3">
        <location>
            <begin position="162"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1925484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="499" mass="56279" checksum="97FE1EA02B68913B" modified="2024-05-29" version="1">MTTLPLSTGMMSRRPKILSDEPKLSSAALCTTLKHLHQTFRPEFTHQCVEEESFRGYQPLTSVLAKAQSELLPSSSSTSDSDAVVLHKSHLRHEQQVTSELEITIDLAPSCRTCRLLVTTKPKKRKANDDDETMTMIGDDKRQKMGDNSSKVPCIHNTTKETEQAEVEPMSLAEIQNAISKALPDITVDNDDMDCIDDYLSKPMGTLLREYTINDKTFCLSLANGSDPATCDYHQKVQKLALWFIENADDVDVSNEQSGHWKVLYLFLHCPKQKYAVVGYCTLFHFNSPFHKPVPGTIVRICQALVLPPFQGQGHGKKMMQCLYDAVHNRIEGAYGNSQDQQEVVEINVEDPAPGFVALRNKVDWKLLKDHPEYWSNAKVDNNIAEEAFFASIPEAQAIQVGANAKITPHQVHIVHEMQRLEALHNATFDTSTNGGGGVNEEELERRYRLLVKRRLNKDHREDLSSFGTKDAKKAYLAKLFDEQLALYNRLLPKGSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM17</accession>
    <name>A0AAD2CM17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS6421</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000129">
        <property type="entry name" value="Leucine-rich repeat receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF81">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE CEPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1939087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="65223" checksum="F12289E6BA367921" modified="2024-05-29" version="1">MAKPSVDKSKPKSKQKKNVANYSNPSNPPIIPGDLELDPIPEDTSVAPSSRAGNIHNNAMSSAASAVASSNSSSSSDMASSLPQNQSHQSHQSHQQQRRQQYNRNDSGSRSDVTGSAVNELMYGADSEQSPPHEKPPEVFCNKRVRIFTLFLILLLAGIGVGIHFIVQAIDEENEGKYGNNNNNHNNLGQPTMPPTYPTFDDVFIDGPTPVPTYSPIQIQSIDDVLLELSAETRNVVNGNEVVNLNDQSTAHGNCRFWLTQNDEIDLNVDVNGQARDIERIQQRYILCLLFEHTSGQNWQLGNGTFKDKTAHECTWEGVTCNGYDYVAVLDLWNKNLVGSIPEEITSLATLQVLRLPNNTLVGTIPERLLDLPDLLWLDLSNNQLTGSVVSSTASGSSLLTLYLNANGLQGTIPYFPQLTSLRIHGNQFNQLNELYTTSTPLRRLVAYNNNFQSTFPQTWNSPNLMHLDLGLNQWMGSIPPSLWQTTPKLEFLLLNDGQLQGNLPSTTASSNLQYVWLQSNQLTGTVPETFGQNWMNLTSLQLQDNDGLRGRISASQCMQWEKQTFETFPEVIRADCNFVSCSCCTSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMB4</accession>
    <name>A0AAD2CMB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057491">
        <property type="entry name" value="DiatomPyrShell"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25192">
        <property type="entry name" value="DiatomPyrShell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041966351" evidence="2">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="283" mass="30457" checksum="D0E85C39DB248F07" modified="2024-05-29" version="1">MKITAPLFTLSLVATASAFQLQTPGARFSQLNSAPPATGGPEPIARSAGLATPGKVKAGDQTTPVVIQGESLRTWSFTSAAVERVQVIMKTEGRPLDTDLELWQGPDNTPQKMRVYVEDGKMRTFNCIIETPRGPNTVCIRNTAHMEFPLYAGVAPIDGVGLESNATPRTIQGGALRTYPFEPNVDSVKVVLQTDGRPLNSRIELLQGPNNIKQVMELYTEDGMDRPFVTILETPGSGNVVRIVNTATMEFPLVCQAEPFLIQDIASSAEAVMGGSGPGFNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMD9</accession>
    <name>A0AAD2CMD9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS6536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMD9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21377">
        <property type="entry name" value="CTWD_Cns1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="4">
        <location>
            <begin position="354"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1939317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="563" mass="64746" checksum="FEC9CE78FBC7F896" modified="2024-05-29" version="1">MTTKDKAADPRHDELMTKMEETRKKWLAEEEEEGQDDTDRLLQEAINMAVSQGRGWAPGEKEEYMAKILDDDFIPPIFAENQEELEASGLAEAFSSLHYDDSPSVVALEFKKKGTDSFLNGKRNEAKNVQYFRDAVNHYYDAFAWAQKIEPLEHRQQNQKTETKPDETKMDKKEKEPTHDDAPEYTEKELDEFKSTIMGNAALAHMNLKNWGHVRDDSKKALDFNKENVKAWYRLAKAYQMLQCWEEAGDAIDSGLGVPNEAQNKDLLKLQKLLAEKIRKARVARQKREKRRAERVSKVKKLWKHCKEQSFQLGRVPLVGSVGDDDEDADDVAESRWHHHHPHTGQLPEPVSGASDWVWPCLFLYPSHSQSDFVKQFAESEMLAMRLAEIFPVVDGESNENSIPWDYDNEFQCDKLAIYFEINCPSEESIEKTKSGKPIVHPESVERLVDQGSTMRFYESSRALKGDEGPEMANLVTAVERKRLYQQRKIWKKKHGSLWHLPDPLDVVRVHPAMTLKGILSDPRMVVANFLVTLVVIPENHPVHEAYLKEHKCVGVLQPDEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMS8</accession>
    <name>A0AAD2CMS8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000435">
        <property type="protein sequence ID" value="CAJ1934980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF3">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXV) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="824" mass="75162" checksum="6BCD9323BC07083D" modified="2024-05-29" version="1" fragment="single">MLGELGSVGEDGSVGELGSVGEEGSVGELGSDGGISVGEPGTIGSDGELGSVGEDGSLGELGSVGEEGSVGEDGSLGELGSVGEDGSVGELGSVGEEGSVGELGSVGEDGSLGELGSVGELGSVGELGSVGELGSVGEEGSVGELGSVGEDGSLGELGSVGEDGSLGELGSVGELGSVGEDGSVGELGSVGELGSVGEDGSVGELGSVGELGSVGEDGSLGELGSVGELGSVGEEGSVGELGSVGELGSVGELGSVGEDGSLGELGSVGEDGSLGELGSVGELGSVGEEGSVGELGSVGEEGSVGELGSVGELGSVGEEGSVGELGSVGELGSVGEDGSVGELGSVGEEGSVGELGSVGEDGSVGELGSVGEDGSLGELGSVGELGSVGEEGSVGELGSVGEDGSVGELGSVGELGSVGEDGSLGELGSVGELGSVGEEGSVGELGSVGEEGSVGELGSLGELGSVGEEGSVGELGSVGEEGSVGELGSVGELGSVGEEGSVDGSLGELGSVGELGSVGEEGSVGELGSVGEEGSVGELGSVGELGSVGELGSVGELGSVGDEGSVGELGSVGEDGSVGEFGSVGELGSVGELGSVGELGSVGELGSAGEDGSVGELGSVGELGSVGELGSVGELGSVGELGSVGEEGSVGELGSVGELGSVGEDGSVGDEGSVGELGSVGEDGSVGELGSVGEDGSVGELGSVGELGSVGELGSVGEDGSLGELGSVGELGSVGEEGSVGELGSVGELGSVGELGSVGEEGSVGELGSVGEDGSVGELGSVGELGSVGELGSVGEEGSVGELGSVGEEGSVGELGSVGEDGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP69</accession>
    <name>A0AAD2CP69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP69"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000154">
        <property type="entry name" value="Vesicle-fusing ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042249030" description="Vesicle-fusing ATPase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="323"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1940092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="632" mass="68820" checksum="4C6E4CD02AF8437B" modified="2024-05-29" version="1">MNRFGDRISCLVLTILCQFVIGTAFLTPTSCRAVASSPSRQDMKNVPTPLASSSSSSSSSSCSDFTPDVDKNTVYVRGLMENLSTLCDKYIVTGSEPTRKRLLNVLDRIYAESFDRDLVLQSVRMAKRAAVPFNDEKYLRERNTRSNEYIMEQKSWKKTDKELGRNDAEERRQEAASRKEWESQRTSQVGDSVADNLQGRSALSRRDNGSQKPDLFMSNVMNPTPETINTMAQEKKELHDEMEGTNGSSEPQEGQSLSVEPAVYESAANRVSELIAKAGGGSQFEGETLGIGGLDDVLAQVKRRVWIPLAAPPSLLQDLGIHPVRGLLLYGRPGCGKTLLARTLGNILSPMRPITVVSGPEILDKFVGSSEKNLREIFDNPPDIYDNYRIGEADGGQAISSAALHVVVMDEFDAVARTRGGKGGKGDQGDAGVARDSVVNQLLAKMDGVHPLPVPTLVIGLTNKRSLVDTALLRPGRFEVQVEVPPPKTVEARVSILKVHTQNMNRAGRLLVRDPPKGTAAEKYYHEHTSSYILSYDELLEDIAQQCEGYSGAALAGVTRAAASHALERAVGEISLNGDSSAGNSMMDCLVTPADFKEAVADVKTSMGTSDFSEESEEQGEEEKPNGEEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPW0</accession>
    <name>A0AAD2CPW0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS6463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPW0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF20">
        <property type="entry name" value="TRYPSIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042133121" description="Peptidase S1 domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="68"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1939171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="666" mass="70901" checksum="49C472AB5B674D72" modified="2024-05-29" version="1">MSRRSIFITLGVLALSETARSNQLRGYLRNDRHDHVKPTSKSDENFIPFDNDEKDAKSVAVKKGQARIVGGTTAPIQPNFVMNLAITENGFKFGGCGGTLISRCHVLTAAHCVTESGLNAANALYINAYKPSANNDQIPFHFSSVGSITVHPNYDSEWSSTNDDIAVIGLSSCVDEHPFKEFFLQSIMRLADYGFMVKMYEGRPVRLSGFGRKSQDPGSTFSSVLQSVEVPYISNEMCKERFYGEHLHRDEVCAGRWDGGKDACQGDSGGPMFVEEGNVQTQIGVISWGQGCGEPKKPGVYASVAFHHSFIMDVVCETLNTEEICKNHPSYVPLTPSPSRIPSAAPFESPSEAPSSDPSQSFAPSDSPSANPSSIPSAAPSTHSNAPSVEPSHTSSEMPSEAPSVSPSKSTLAPSDSPSVHPSSSASAAPSATQSNVPSVTLLQFSSETPPGAPSVAPFTNTSAPSDSPSLTPSVVPSDMPSLTPSTQPPVSESRFFSEIMHSSSEPIDAPTSKLSQSSSEMPSGAPSIAPSKSILAPSDSPSLTPSVVPSDMPSLVPSQFPVSESRLSPEIVDSSPIDAPTSKPSKFSSGFLIRPANAPQSCRGICYEPWSFTMKNPNETVILPNGTEHPCFLIDSVLKMQQEDTENNLCIKQALEARNAGCKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ73</accession>
    <name>A0AAD2CQ73_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS8113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ73"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="583"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="624"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1942770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="705" mass="79663" checksum="10E861B276C0613B" modified="2024-05-29" version="1">MMSNRGSKSNSLVAWKAVVLGGVCGYLLATLTQSFDGGLTNGSQRRWLAEEPSEGLHQGEGSEEGEEVIDPTTMDATIALIVLLLVILTIAFETIKEYIEEAADHNMRPIIASLFGEMTVLGFLSVFTFCVTKLGFFEEISIHLFEEDEALLEIFEFVHFMLFFIMVFFVTSVLALVAGAQRTEDKWFIFDMACRDPEYMKRLEGWDSKDTDVTQAGWFIYFLKTLFPFTASKTEGFRKELRLFRGLRTEFLLQRSPEPPFEPKPNNRVHEDFGMGQYFSACLGHDLAHAVHLNHITWFFFALLTLVFYIIIVIVDNQFAIFAWFWVGAGWTVFIVRNIFDYHIQGVLQGLASPSSSNGIASESENASLLSLPLPAWAHFSLDEYNNGQSLFVKFLGIRGLRGKVTRQDALYWFGRSGPKLYSVVFQIQLVFTSAYVSLLIVSFFKIMYTQCSSAEWTAYLILSLLPLYYLISKNQDIAANMTIVSNFGVHRRPQVVSQVIRDEKIDRIIRAMAVIFKLQRAIEQGFDGAAGTSHGHHNPNGKANSSELQEVAKAFDALDPSSDGKIDSSELSKILGKLGLPVSDKITNEILQVLDENGDGVIVREEFLAFYSQHVSTSMDHHGIHELAHQMYHQFDRDNSGQITLEEFQRMLEAFNVGFTVNEIGDLVNELDEQNDGTVGEHEFAELFESRDYLFVPRSLPSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ90</accession>
    <name>A0AAD2CQ90_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041994612" evidence="3">
        <location>
            <begin position="30"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="23534" checksum="332BD841D8B358D2" modified="2024-05-29" version="1">MKLINSSSSTKRNCFVSFLLLCLFELTSASTSSLTTTVDGNQIARRAKRGANNNYTTKSKCVEKTTPMDDGGNKVTTKCVHQVVFDNDDIDTMSPTWNPSATPSTLPTNSPTSATSSAPTLGPTSGPTSAPSGTPTWGPTSGPTTGPTSGPTSGPSIEPTSTGVLVSTLPAVEGRGTKVSSTKAAIGALVGGILGFAVLAVGAKAVETAWNRRSTSDDSSIMALGDEEQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR78</accession>
    <name>A0AAD2CR78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS8523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042254731" description="inorganic diphosphatase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1943601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="268" mass="29813" checksum="0FEFD9B06887E126" modified="2024-05-29" version="1">MKFPIVSILALTVPASAWAPAAARPTFATMASALFSTSTEVIGEEATESFRLKFKTEDGDISPWHDIPLSSEDGSYNMVVEIPKMTKAKMEVSTKEESNPIAQDIKKGKLRDYHGPIFWNYGCLPQTWEDPNVEHPELKCFGDDDPIDVVEIGSAALAMGSVKPVKPLGVLAMIDDGELDWKVLAVATDDPLAKEYNDIDDVPESIKAGIREWFRWYKTPDDKPINSFGFDEKYLDVATTKEVIEETHEAWKKLKSGETDAGKLWIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS21</accession>
    <name>A0AAD2CS21_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cathepsin propeptide inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS21"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042115071" description="Cathepsin propeptide inhibitor domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="130"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="197"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="339"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="411"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="471"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="591"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="709"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="1013"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1941229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1135" mass="133481" checksum="734DBD771E4E552F" modified="2024-05-29" version="1">MRGRTLSLALASVIGIANVQAFSMKRPTLTSNAPLTIDLVEGQTSFSKLSKQDVSARTQPITTNDMQSFSHRDRRGGFSTKAKPTVATIDEDTPTKTTEKTEGDDDTVYGLNMEFIDDPKDMDVFIRNEYNKWLQFHNKEADESRYPSFKENFLNQLKYDVRSAKEKGENPQFFHLNEFGDMTPKEYQHEMVTLEAYENWCKAHGRQQDPVKYPVFKHNFRVVQESKAAASTNSTEDKSQILNDMNAWKGLTEYADLTEEQFSWLTSDELFLNHRYAKWLKDYGKEKGNFPEWKRTYAQQLASIHRAEHQHVVKSFIFDELSDLDDESYKIEREYKDAYTSWCLQFNKPENPARYDIFKMNFKQQILKTIAKIDLNATDVPDLPVLNQFADLSLGEFATIVSTETFIQKEFQAWSDHYHKTTGSYEVFKANYLLQLEHLANGHCVRSFVFDEYSDLTQDEYDQELICQLDYQQWCDAYSKSASRERFQIFRVNHAIALAQNSTKSMTKDADLTSDEYMTMASNITFIRNEFQEWLGFYGKETGKFETFQTNFLQQLETLKDTYSFKSFLFDEHSDLTSKERQEETRLQEVYRLWATKNSKATTKGRFKAFKANYARSLSLNMELNKEADLTPEEFANNVSNKDFIEKEFNKWLQFYDKKKGNLDIFRSNYLEQLETLKNVHCFKTFALDEYSDMTVVERAWEPFYTTAYDSWCEAYETDQNRSRYEVFKQNCANQIHANVTNGTALELTQYADVSKEEFVDIATSKSFIRKAFKLWLKTHDKDDGDYDTFADVYTLGIHSMDHSCESLNLEENADKTNIHHAVDAVCRREYKSWCKSRVKVEDEKRYTVFKINFLRKLPRCVGKAVDLHEFADRHTDESMELEQLYSAVYAKWTRAFGRSKNGKEYFIFKTNFLEQLAFEETTNETFAFNEFGATSKAAYFQMVSAPEYVRKEFLKWTEQYNKTNDESNFKSFQKNYLGHLKAEQERDDSVPFYLTKSRERQYELDSFFKEKYETWATKFGREQNDDRFEVFKINYVELLRFNNCNSKFCAMNEYADSTQEQWERHSSRRKPAFVPDSNRAEKGSKPVSLSEDMLARLDRRSNTRRTPFFASDPVQEFEAFTFSSKESDAIESSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS98</accession>
    <name>A0AAD2CS98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001280">
        <property type="protein sequence ID" value="CAJ1944944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11094" checksum="1842DFB18DDBB015" modified="2024-05-29" version="1">MKWMIGASFAVHPDFKSHTGGTLSFGQGAAQVMPKKPKLNSRSSMEAELVAVDDVVTMILWTKLFMKWQGYPIEKNILYQDNTSAILLEENGCKSAGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSX6</accession>
    <name>A0AAD2CSX6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042106672" description="RRM domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27577" checksum="4E56F655BFFEC261" modified="2024-05-29" version="1">MKLSVIVGFASIAASSAWVPVSSMTRASRTALPMAIDYNDPVVAAEFANVQPLTYEEVEAELQECGVRPSAAMNEMEVKLMLVEMRMRLSGKMSGEEPKKQPTKFSSKLEEALWTKPVFADLYNGFKEKDDHNSMNVIAEYLNDPKMARTRYEKTYKGLIRKIDKAMTAPPPVNSPTLQFSGFPANMGEAGCKMTLESLGAIADFECAEDSDFPVLTGKVTFEDIESAKKAVAQYHGMDMGMGTSLQLVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT52</accession>
    <name>A0AAD2CT52_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT52"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="47476" checksum="629B3B7F7C0F0939" modified="2024-05-29" version="1">MAVRDIEAGQMLSRPSMGCLENCDDFEHTNFIETFKNYGEVQQFPHAWKFGMDVAPIYHGRHEEKTKIVWIKPPRYERQATLMVALEIQRLEYKFEVIPSRETVGEREWVQIDRYCQSVVEVLEDMIEESKAFDLIGDEYDEDEDEYEQDSEDENSDDEEGSDDEEHEDEPVANESNETGKENEVLVNTEDSTEAHVASDFLEGRNSSSNGHPWMVDGCDLSEDCSIDNKGMWENLLLQRLPKRNIMGSDAQRLYGNCRTRSILNRVGQLWNRSPVFATAEIPKGTLIWTSKYTATFTDGVQFRKVLSILPDDMVCDLIIWCYASEGENDSEGIQSEDGTSIPVQDFFECDLDDASFFNSYDHRSEYNVGSQKGKVAASPDDDKAYAMRDILAGEELVSAYDEFDTMNYDAFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTK1</accession>
    <name>A0AAD2CTK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Malate synthase</fullName>
            <ecNumber evidence="2 8">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS8413</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 8"/>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="9">
        <location>
            <begin position="162"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="11">
        <location>
            <begin position="418"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1943385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="542" mass="61297" checksum="88ACF1C8E9EAF155" modified="2024-05-29" version="1">MMEYKSESFHIQVHAPPSDAANEVLSTDALRFVGYMCHTFHERRQNLLGARKQRAKEFDAGETPKFLNIPAVQDPNWKCASIPSDVQDRRVEITGPVDRKMVINGLNSGACVYMADFEDSTSPTWKNLVEGQLNLRDAVQGSISYTSSCTGKHYSLGKKTAVLFVRPRGWHLNEAHVTVNGKLASGSIFDFALYLFHNAQRLITKGSRPYYYLPKLESHLEARLWNDVFITAQQYLGLPIGTIRATVLLETITASYEMEEILYELRDHSLGLNCGRWDYLFSYIKKFKLHPDKIAPDRSCLTMESPLMEAYCKRVIYICHKRGTFAIGGMSAVIPRKDDAKKNEMNLKCVANDKEREVILGHDGTWVAHPALVKCARDIFDKHMFAANQIESKPMMEGAKVTEADLLLLPQVPDGKAITSKGLKCGVKTVLHYTEAWIRGVGCIPLNHKMEDAATAEISRAQIWQWRHHGLVTQDDGVVITSHRISSLVDNEVAMHTGGRWKLAGKLVKEMLSQHDRLDDFLTTVCYPYIVTTHCEERRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTP9</accession>
    <name>A0AAD2CTP9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="107" mass="11943" checksum="E184F9E059CD4CBA" modified="2024-05-29" version="1">MNSNTTTMNTSKNNSKMESHLNRSISDLSASSQGSADSNVSAARKLRRMKRKLLLDFVNDDPTNNDTNDYNDNDDDDASTVVMSNEREVLSLFSWSADNNPRLASQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTS2</accession>
    <name>A0AAD2CTS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000546">
        <property type="protein sequence ID" value="CAJ1936099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTS2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="47"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1936099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="220" mass="25549" checksum="CAED5E5E6E56BB49" modified="2024-05-29" version="1">MSSASNTTSEFLPALQFGCKPTCKLPTLQAQRSREEYQQGKRWVMTVDGIHCWINEPSHKEWSQDPKYYSHKYNKAGLDYELGISLVDNRLLWMRGPFPAGTNDITIFREKGLLDELKKRKQSAIGDRGYNGEPKHMSTYNAHDNAGVRLFKSRALKRHENFNSLLKQNKILDTRFRHNEDRFASAFEACCVLAQYRITREMSLYDILIEDVVDTYEGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUA7</accession>
    <name>A0AAD2CUA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042151325" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="78222" checksum="98678796D520B339" modified="2024-05-29" version="1">MKVLQHLILLFSNSFAVAKLGASLHHDDRRELYPILRFYGSSPSQLLGRCEGDCDKDLDCISADLVCFQRGANDVVPGCSGGQSDVSLSDYCVLRTDLNAPPSTPAPIPAPTPYITPRAGIPIKYTTNFPLGLCEGDCDSNFDCAGDLVCFQRDEFKPVPGGCIGGENDGSRTDYCVPPNIGDLTPTLPPTPPPVPSPTPDLPIKWSTNFPLTRCQGDCDSDLDCIGDLVCFQRDGYEAVPGCSGGESDRSRVDYCVLPNYNDQPTPTMPPTPPPTLSPTPPPTLPPVPITTPTVAPVPTPTPPPTLAPVPNPTPPPTIAVLTQKPSRPPTVAPITNPTLIPVPIPTAAPIPGPTPPPTTAPIPNPTPDPTPPPTVAPVSDPTPNPTVATPPPTLVTPPPTAALTPPPTPPPTSLVPIQWSTVFPLRLCQGDCDSDSDCEGTLVCFQRDAGAAVPGCSGGETDDSRVDYCVVDKDRMGPLPTPPPVSGPGVDKPIKWSTNFPLGECEGDCDYNEDCGFGLFCWQRSSGESIPGCSGTDTSSVDYCIPKSKAPGKKIKLFWDNYFWQESYVERFWCMTCTECETLTTGDGWEGGCREPENSQCKEGHLIWIQRCRDTRNRMEIIENARSGDQVRVYGTNLCFSTINGRWLELKPCDNSLSNQLWTPLADRNKFELRPYSQRNRPTNEATCLSQLHHPKGTEVIALRSCRENINHETNYWTEYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUU1</accession>
    <name>A0AAD2CUU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUU1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="6">
        <location>
            <begin position="78"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1942394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="221" mass="25815" checksum="CA4B111D293AF3AE" modified="2024-05-29" version="1">MIDGSTIQSIFGPFGSEDSLLPFFGPLTLWVGMYTYSHVKGTSYQDWPIPHNTHHFFGMIFATLSIIYDNEEIFPERVGVLWTLSFFVIDFIDCVRVMHTAYLFHAVCVLFLSSCNLMNPSFYRLRMNSRAMYLELSSPFMHLSKKTRNPLHFAIFALMFTCCRVVWIPLIMKRLLDDGLPWTDYKFLVVIAFYGLNLFWYAKILRIIIFGPPQKEDKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVG7</accession>
    <name>A0AAD2CVG7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="206" mass="22517" checksum="DEDEC7E58AAED05D" modified="2024-05-29" version="1">MKNSKTALALGDDWWNSLRGMFENFTNGGNSGDDDHLPAGTSVIASIPVKSLKPGGLRLFLMFYLMGEQNTPDKGSWKAHQPDSPPSPMVPYSSSTISSLDSDEIDEKGGDTEQSVEFDSSYVLEMFYKDASAMISIELLPHEVQIKRCGSLPSTAYLMHETVLVEGILDELAQCAFDDRVEEANRLLILSAPDSIDSARSTLSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBT1</accession>
    <name>A0AAD2FBT1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1902684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBT1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF7">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1902684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="503" mass="57253" checksum="F81CD6F07AFBFFA5" modified="2024-05-29" version="1">MSRANTKETRQRRARSNAKKHQIIPTWVLFVTPAMLIFMGYASEHYRKSRGLDPLLRRPLSKIASRIASRSSKSNEYMRRSLLTAEEDGALEKYDGKTLHLIFSTDCSPYQHWQSYLVYYTAMKVKQPGHVTRIVSGCEDTEADQMKSWFENNISHMSKRFHLHFTPHFSQVVNEEGKIVGDYKFFNKPYGLRHWLQNFELLGFNDGKFSNPDDIVILNDPDMALTRPITGDFSDMEETVISKFRQGDKILGTKVTRGMPFAQTYGLGVQWQKFDLDKIAGPDSPAKQVSKEDGNLYYPVGAPYLGTLGDMYKIANKWSEFVPRVHAQYPHLLAEMYAYCIAAAHLKLPHQLIDSLMVSSPGTGGEGWPLVDVIPPSETCGFAQGPDHSKYSLPSVIHLCQRYSLGEEWFFGKRKIPTDIFECETPLFEEPPANLATLYDFKKPPNAKERTPLTPKVANEQAFMVCFLTSLLNEAATFYKKSGCSVESVNFQRSRTVADLFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC25</accession>
    <name>A0AAD2FC25_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1899805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC25"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="196"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1899805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="441" mass="48977" checksum="FA453F3DDFE8E89E" modified="2024-05-29" version="1">MNGIDITNYDVLVAPPIPGESEEYQLDRGKNHAGNNRLEVFLNMHRSSYDSARSRADFGECDNIVEKIVATVCHQCVPKGRFLVSSSSNSGESVFWNQMDEQNAKLFLHSVLRPIRPPPMQEFFEEKKRRRRSSLLRRSASESMVLSVLDSKKKLSKMKLGGTQEEPDWMSTQAGGVTLRRMDVMLTDGGQALDPNSQSVGNNRLHVLIAMNASKYQNASIDEKEKILNEIVGTVKIWTGRFLVQGGNGYEKLSNEDAMNALRNIFALRAGQAIPKRSSLPNPSLVQLPIRASDPMAPPMMMNVTRQSSAPVLDLSRQSSASMINSGPDVNMPELETLRLAAVNNLKKKMARQKIASRLEDKSGRGSVNPQQQERQQIASPLGAARRPMMPSMAMKRQSSVFGISPDLMQELAAGIDDPDDYNNRDPLPPTQSNDFASKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDM1</accession>
    <name>A0AAD2FDM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS2129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="58"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="421"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="587"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1930873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="676" mass="75577" checksum="B5B2E8CD4F200D57" modified="2024-05-29" version="1">MQKASKLPSLGLRPISTDRSNDAKSIQPPRRNDSSPGTATTASVSSKESSEKPQLKTNIEVCARIRPLEIQTGSAGFFEAPSQRRRTLSKLPKKQAPGTMSKQGEICCWDVSEDGETAAQSENTETVTGRTNSFTLDKVYGMQSTTRQLYDNSCHSLVKAAMEGYHSTVLAYGQTASGKTHTMSGTKDSPGLIPLCIEDCFRYVRECQESREYMIRVSYLEVYKEHIRDLLTGIPQPIRIFDGPKGLIIRGLKEVVVSSPQDVFDALKSGEGRRQVGSTHMNSQSSRSHTLVRLWIESTPSDGRKGSSTRASSLSLVDLAGSESVKLNGLERREEGHYINKSLMTLGQVVLTLSEGNTKTHIPFRDSKLTRLLQPSLSGNAQMMLLCCISPQVSHLEESHNTFKFATRAKKIKQKAIVNVADDENTLLQNYRDEIADLRKQLEEAKQQQRLIKEVPFDHKEETDEEVKELVSAIKTMERLILKSRPHHTPVTPRARVASPRASEMMLDDTLDELNLQDDSDDDSQVAILSTTPGNEMLSTPTKDEEALSIELGRIRGLLGTVLKKKGISEDDPYIQKSLDFASPVRSPEMVREVEHLRHQLEEQEANTNLRKADSSFLQSQLREKDQLLEEVSKVLEQVELRQAELERENAALRAEAFALKAKLSRHETDYECANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDR9</accession>
    <name>A0AAD2FDR9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS2264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000125">
        <property type="protein sequence ID" value="CAJ1931155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="124"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="225"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1931155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35138" checksum="E854A9A0FA59E4A8" modified="2024-05-29" version="1">MYSTLMNQKQQQVMMATSSAAPAAAAATAAKTPLPKSAIFATAGIGGCMGWCVVHPFNTIAVRSNLASAAGQTFTLKGMIEKQGLMSVYDGLSAGILRQVFYATTRFGLFETFRDMLHEYRGHTDFASRVATGLVSGGIAAYISCPMEVAVVRMSNDSSLPVEERRNYKGVVDTATRIIKEEGITAFWRGSGPFVSRAMMVGVFQVATLDQFKEMYCSYLGQVKNSIPNVFCAAMTSGLVYSVATMPLEASKNRMASQKPDPKTGKLPFTGTFQTLAKVSSEKGFLALYNGFFPYYLRCGGHTVSMFIVVQILRDYYREYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF16</accession>
    <name>A0AAD2FF16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS3630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="226"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1934186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="448" mass="50127" checksum="2B99F10899C26143" modified="2024-05-29" version="1">MGNMPGGMGEGGPPSDGRNGKDDDDKVKKKKKRFEPRPANRQGRRRRRKGPSGLNKTPTILPTSKCKLRLLKLERVKDYLLMEQEFIRNHEVFKPHEERDQEEREKLEELRGSPLGVGNLEELIDDNHAIVSSSVGPEYYVNILSSVNQDLLDPGSSVLLHNKTMSVVGILQDDTDPMVSVMKVEKAPLETYADIGGLEDQIQEIKEAVELPLAHPELYEDIGIKPPKGVILYGEPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVADDLSPTIVFIDEIDAVGSKRYDSSSGGTREIQRTMLELLNQLDGFDERGDVKVIMATNRIESLDPALIRPGRIDRKIEFPLPDTKTKRHIFNIHTSKMTLADDVDLEKFVMSKDELSGADIKAVCTEAGMLALRERRMKVCQEDFVKAKEKALYRKKGNVPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHT9</accession>
    <name>A0AAD2FHT9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHT9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="538" mass="59363" checksum="BF40E5B7C3BDEB0A" modified="2024-05-29" version="1">MNALSSEAATKTGSGASSGDGETIRIRASETETDADDENNLRKITPPTLRPTNVPIIPEADTSKGAVHNEPPSSSILQPLNLIPNHQLREHDYFSDSWIITREKFLNLERRRLGIVEDACFVAIGSGGSVYPSSKMFVDWTDFMVEHMSKWWNELRILQDSDSAMFDLALSYFAAYIEKVFASKNKVQPSTFHETIAVVAFAPYRSGRHTADRGHQLTVHSLAATLASLHQVGFGRVVIAGYGQEDQRHVAASLKFLAAQASSSSNHHDIVPDPTMSTTQIKIDNTEFGFAKVNQEDWISTQWVKFNMPRGAVIGLQEALMGKIPEKGQDGNDAAVTCSPAWLGTTHDASYWKYVYLTEPDTILHTKLELLPAIRKGLDDGLSFFPHRLQPIPHGSDLPSGRNADAAISSDHSGRFVPNHILPFSNVTIMLDPTDTVDDTTTKDTDEGSVGVTAYYCCDAGPSPEHENCGTWWWTCGFHDGFVQATMSQEEALEKHKRLAMYPMMRLKQGTGVVFGPTEHGRKCVPSKDPCPQSNDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ29</accession>
    <name>A0AAD2FJ29_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="4">EF-Ts</shortName>
            <shortName evidence="4">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS4274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000424">
        <property type="protein sequence ID" value="CAJ1934939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14275">
        <property type="entry name" value="UBA_EF-Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.20:FF:000001">
        <property type="entry name" value="Elongation factor Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000001">
        <property type="entry name" value="Elongation factor Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041931978" description="Elongation factor Ts, mitochondrial" evidence="6">
        <location>
            <begin position="19"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="7">
        <location>
            <begin position="264"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1934939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="484" mass="51271" checksum="02979AF5F78CA157" modified="2024-05-29" version="1">MKIATSIALALFAASAEAFGPAAPVGGSAFGASTSFSQGGMTMRIGHADMARRQKINNILGTNPTKEVVEEQLLSASNDVMLKKMNWKLRKSTIRKIKNQAQRYDITVDPAFGQPPNQAEREALEQAASVEYKKQKEAIAKAMADQVANLKAAKDAKKASKKATAAAAPAPAPKAEKAAAPAEAAPAPAAASAGGEITPKTIKALRDATGAGMMDCKKALIESDGDQEVAADILRKKGLAKADKKASRVAAEGKIAFASNGQKAVMVEVNCETDFVGKDSSFLGYCDKVASAALNVNDDQVETLMNEESDGESLETTRQALVSKIGENIQVRRMQSRGGDGTTVGCYVHMNRIGVLVEIEGGTESLAQDVAMHVAAMNPPFATPDEVPADVLEKEKKLLSEQALESGKPPEIVEKMVEGRIRKYLEEICLISQNYVRDGDKTVGQLLEGNGAKMIGFTRIEVGEGIEKKEDDFAAEVAKMAGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJJ6</accession>
    <name>A0AAD2FJJ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS4873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000502">
        <property type="protein sequence ID" value="CAJ1935713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJJ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007378">
        <property type="entry name" value="Tic22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33926">
        <property type="entry name" value="PROTEIN TIC 22, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33926:SF4">
        <property type="entry name" value="PROTEIN TIC 22, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04278">
        <property type="entry name" value="Tic22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042007529" evidence="5">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1935713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="392" mass="43782" checksum="A1867816623E13A7" modified="2024-05-29" version="1">MTRLSTICVFACLAVIEARRSFTDMPVIKQARQLLNLNSILGNPTSAQPYDRILGSPVFQVTTAWGSPYMNMEKLTEMDGSGADGSGLFQKDAGSLKSISEEQNEYRTVTLFFMDPDDALGVHAELKQMEQMKKSDIRITSNSLGKALRAAANLGNGLPTGYPIEPLNGNLKPVEEGGSLRHKIMPDKRQLFYAARCIGKERVGLFGDNPSELATMALLGNSAIEATNLMRRRDKRERKTTPPPKSLLEAQNAHMDGYVGIPVFHASGMARKIPKLKQISSGNRQETPMFFNYEDLQDAWTKMKKKNPSMPDKPTVEVFNLFDVLTSMDKDQWKKRKEAGKFDIMAPLRQRFGKLEGPDLDSITFVPSSRAIDYKEKLSARGNGKARLRPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKJ1</accession>
    <name>A0AAD2FKJ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKJ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="403" mass="45585" checksum="A018217A726BAB0D" modified="2024-05-29" version="1">MLAIKPDNSRRVKTLELEVGRINVSGGGVLLGEPIGLSDNISFEWIDNSYQWEPKIQKLKEDQYALTLEMDPSELKSKQERLNQEFLERTPSIFGAPNCNRDNSPIDTPKRRAFQKYMKEEFGPRFASLAKTDLRAFEELLMTEPLGLWNSNELEDEMHGEVLKNPAALKVMYAVLKSRYQSGDVDAYRRWIDTFDGTPGYTSDGDSYWDPVPVDLPRPLALRSLPKSMARFDSKEAEDIFMSIYNGIFDVKWMAGSRDEHPDEVVSFSRHLPPEANFKFSSLTAFAQNRSEVMTTNIVIMPMPGNPNQAATLQTFNTEDPYKSMFTVEQKSILSHRLVHCLNSVGEAMEAAKKFEAAAKVYGESARLMASKKRYSNAASLFQNGGLAHRRSNKFESAESACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKP7</accession>
    <name>A0AAD2FKP7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1938068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKP7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="173"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="894"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1938068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1098" mass="120264" checksum="BF3EC35DE5BDC91A" modified="2024-05-29" version="1">MPSSPPSSSSSIKTLHDPQGSTWLNQASMVWDPSMIDSNSCYWDDQWLSILRATPTPTRAPLENDDDSTTDKNHDHGSRSRDNNNKRSNSNQTWHENHYISYQTLFATAALMVVELRNELTGRFEQQAGDDNRRKRGMPVIVAIPEGPLLPLATLVVHALNQPVAGTEASCFAILVPLEPSEAKKRNLHILKDITPSMILAVPGRDFDNLRLMVDSLATITPEFVDFSTLLRSVTQNMDEAQNVIFHSEICLDANSHIGTVIADLANELSHELQGAQTSEKGGLLVDEPRVSHIVYTSGTTGIPKGCISSISSLEQYLKSKNKVHDINQSSTVLLASALSFDPCLSDCLATFQARATLALAPRSTLLSDLPNILQQLQVTHVLCTPTLWSLMDGRSHRPAITDFPKLQVVALGGEPIPAQLQNAWGRQGSDSAEPCRLLATYGVTEACVYQTCGEVFASSKKTKGQFVGQPLEGIGVRICQEGDQDKLIDVEANRRIGEIVLYGSQLDTISGYLNRPDLNRKFQIDGTTQHYRTGDRGTFDAVTNSLHVSGRIVGEEGMVKVNGVRVELGEIENALIDVAVNSSEEKPVVLHCMAKVVSVVSSTGTDAPSPDRKEIRVYCVLSEDTRKELNIKNDESSSGLIVNGGPILTLLRSRCLENLKAACIPKAFVIIPRLPLSATGKRNRDGLLKLDACRPLQSAEEEPVLLKDFGKSGKKVAEVLTELLNLQPSQESMLTTRGTFAMLGGDSLTATLVLRALYAYHHNVQNNRNLGGEYGKLTGAFDVLSLLGSENLGAYVELLDSKKLCQPKGEEEESSQSLEEEREPDDDQADVRKPQDAEAVKQKVLYDALVQAISLGQSSIAMGLLNVGACPNHNLHSGRLGKVTDRLQQRAMFRSSPIHIACLKGDASVVKKLLEKGSKTNSPDASGRFPIHFASMGIQTTDETTSESEADDKKQRLLCVQYLLDAGAPMTMRDGNKQSILHCASRSGHCELLKFVMSTWKDKNPGKVTPKHFFNWNDRWLRTAVHWAVLNGKVEALQVLLEMGSSPSPFKPKRNNRSSAAVESPMDMCQRLYDIEDGGVGTKIHSLLSRSDEPTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLN9</accession>
    <name>A0AAD2FLN9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLN9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1942132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="368" mass="40835" checksum="86647A89754A6AC6" modified="2024-05-29" version="1">MCRVLFQGPLFGRLTKAGRDYLLKNGWQVLLENNNDDADNFNIAAVPLGTQRLGFVWPTKTGPQFQIDDATAAHIRPFPKHMTDIFDDKLQLAEALKGTTLAPPCLLQPLVPKTIDPQKLYFVKHRYGAQGKSVYVYSKDDLLAWHGRSQNPQEFVIQEEILPALHEGRKFVLRCHLLLVQNRDGNNDIHGSHGSHDIPSTVAGFVHKTSIICQHHTTRYQKGISEKSSQVSQAGKKHPAPILFQDLPSDHPCANAYDQIFHSCQTLCSTVPISSSGTTNATTTTTPPPTSLAPETTCFGLFGLDLMMDSDGDIKVCEVNSHPALGWGTMSKVPQEVFERLIEETLSLLLQNSDPEYAESNFDKLGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMF8</accession>
    <name>A0AAD2FMF8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001447">
        <property type="protein sequence ID" value="CAJ1945686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMF8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05379">
        <property type="entry name" value="CAP_bacterial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="432"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="549" mass="59536" checksum="D3086B10574C43FA" modified="2024-05-29" version="1">MPAAPLDSMNGKKRIAAVRRKSSVVSEENIQERLGLRRQASTVRKSVILESLGKWETGGDLTFKQSPKIDSISETTRPRSFDDGPLVKEEMEGETLAKGNRAKSADARTSSVVSPIVPKQKTSKKAVGSMSPPVAPKRSSAPAKETETAAVSPLAPKRVSVSPKSSSPGLQKISSKRISPKRSSRKIKRASSRSILKDKGSPSNGDHLLEGDDDSKKPQTSASSGSGTGNSIGNGGSSVVSAPSKLPPNRAKRRTSKGPKSAKSMANGQKPRRSKSSDLEACSEGQTKAKKSKRRSKSADNDVDFGPDILVDEEKSEKSKKKGRTKRRSSNKRTSAIQSTDVENDKEGNQQSNPQDRRASLAGTKKRAHSAGPLKRKTGEANEKPALPERAASMMLNRDNTRRGKANSLHNLVQYSAEEIHSTSYFASNHVLVNRERMKRGLRPLTRNIAMDSLARESAESMAESAGSSPLRTTYVGNVLRGESIRAVHRAVMLNKQGRERANMLNPYFQDFGVGTAKGKDGMLYVCQLFSERLELSCTDLVVDEEKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMH1</accession>
    <name>A0AAD2FMH1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001525">
        <property type="protein sequence ID" value="CAJ1945807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="168" mass="19348" checksum="8B930BBBE23F8E21" modified="2024-05-29" version="1" fragment="single">MNLKELDGYEAIWKKVTQDGLTFDKDGEMDEATKACFLDALKPLMASFEPKSFEVSLEFLMRNHVLMRKHIHYEDVVGKMFLQQFIYNVFSALLLSACSKAGDYKADQMVRPSLPCLFRETPDENVWRYGDFQAKPDAVSSMDSGCDPFAMMELRTLYTRRNATIVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNV4</accession>
    <name>A0AAD2FNV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNV4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF32">
        <property type="entry name" value="THIOREDOXIN-LIKE 2-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="72"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1947297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="244" mass="26265" checksum="B5F21007E0BCD6AB" modified="2024-05-29" version="1">MRASEGLTEFAEETAEKISFHDQQDGDGLMNDVSTVGQIAICTAESCPIPMNGSHDGPSSVDDSKTSESKSQSEGASNPTIASSEKLNKKNRRKSKNKNKKEGGTQQSVSSIQQIHTQSDLNKVLQEHDTVLLEFVTTWCTACHGIQPRYEELAKGEMGSNENSDAMLRAAQVVCDKNKETKKLADANGVGSYPVFVLYQQGTEVSKWKGADVGKLEKAFDNYGGSSGGKRGKGGNGKKGKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNY6</accession>
    <name>A0AAD2FNY6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNY6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46662">
        <property type="entry name" value="DI-GLUCOSE BINDING PROTEIN WITH LEUCINE-RICH REPEAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46662:SF107">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE GSO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="84501" checksum="7139939124C6DBA9" modified="2024-05-29" version="1">MPSNPSTPNRHGYPEVASGDYDAAAMVSDDEEAYLRDIIGGGTERQDSQDALNNSMAEVSVTSNFTEKFFPPSPSSKNERKSADPPMVQTPATPTPASPGHPAPPTQYVVNDPYNAYDDDISTIANDTYVAKYMAGDNNPNQLPPTPKTPHQQTAYHSGVQGPASPDQTDGASQPTHVYTYNKLPKQKTRFQTDQAESSTSEESGGNTTGGKMGKGDDDKSVFSFASYKRFRGGSGWSRRNYMLAVCMSLFLLAVIGGLGYTFLRLRAQGDEDVLDQRSQQAGQPNANGGLNNPLPGDGIGGGWTLRPTGNPEPTPAPTITRSNAPSPIGPSPRPTPAPTPRPTKLPTSNPSMTPTTSPTTPFPTTSATSSPTGSPAEVLRQLLLRISTGETMLLINIPGTPQNRAYEWLHQDPNFTNYLERRLVQRFALAVMYYSTTQPEDAQESMQTWMSYDSNECTWFNSWFENRLACGSDDIYKFLTLRNLNLVGTIPSELAFLSKLNSLTLSNNGLSGSIPKEFGEWDSLENLDLRGNYLTGRIPEFKNIPNIKNITMNWNWLEGNVPPSVTKLDQLLHLDLTENSLFGFMPDQMCTKGLETLAVDCDQVTCNCCTKCGSEETRAPVVLPPSLPTPPPTRPPTPPPTPLPTLPPTPPPTFFGQCVDAIQPTKNCYTFGEPLIINFRNCVPNGNDWVGIYPDNVLSGQHFNPSLWKWSCNSQACADLISRGTVIMDATATGGSQWPLAPGEYKAWLFRRGGDGGAYPAIVGTTKFIIRNGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP22</accession>
    <name>A0AAD2FP22_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11401</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16328</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001920">
        <property type="protein sequence ID" value="CAJ1956639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="16638" checksum="C19E9A2ED13C2EA5" modified="2024-05-29" version="1">MRKYNDSDCNICPSIASELDLSSLLIEDSIPTTIGNDESNGSFSTVDTNNLFLLAGESSFSSLNVEVSVPRSIKQKSRAGTTRKPESKISSSSSTHSRRSRKSNHNSSPDKYDQVGTTRRETRREASFEEGTDKRQQLRRSCENLSLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPB1</accession>
    <name>A0AAD2FPB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS11471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001742">
        <property type="protein sequence ID" value="CAJ1948129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000079">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="387"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1948129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="731" mass="81941" checksum="6C681D091949FAAE" modified="2024-05-29" version="1">MGWFGGSGGKSKSSKGKKGSKNKGGKPGAKNVPGGSTVFRVTVPDNVKPGDEFQVYAGNRIVRVRCPLDSRAGQSLQITVPAEGPADAPPQERPRDSDNVRKIEGSNPPAFMVGIPEGTAPGKQFPVIVGGQQLMVTCPQNARAGMSVRIVPPPMSTDVTQQPSADAPANAAPKAKPKPKPTTQLFEVQVPQGVTPGSPFALMAGGVRVLVTCPPNAGPGQRIRFKLPLELVQKPKATNEATQIKMKYGKDGWQRTVRATDLKFQWVRMDEKGDVDNAKRFHMEKSAYVRRLDFRPGNDPRIRTGLLSLIPANESATESKIKAADGRDLVTYSDLANAQVKDFADKAQWFQDTCAQLCVEWNEGHMRMNVRREFLLGDSVDAVMSLSRKDLRKLWRFEFIGEMGIDAGGLAREWFQLVTEEIFDPDMGLWQSSATNQMSMTINPNSDFCCEDHLVYYRFLGRVMGKAMFDRQLVCGHMVKHLYKHMLAWPIQFKDLEHIDSEYYNNLKQLQGMHDNDDDISMLCLDFTTTSEIMGQKQEIELVKGGSDIEVTNENFPEYVEACLKYKLMDMVKPQLTELLLGFFDVIPEPLLTIFDFQELELLMCGLPEIDMADWKKYTEYSGEYEEDEEHQAVLWFWEVVTEMDHEMKARLLQFVTGTSGVPSRGFGVLQGNDGNIRLFTIHGLPMDVCLYPRAHTCFNRIDLPMFDSKDDLKEKLKLAITMSSTGFDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPS0</accession>
    <name>A0AAD2FPS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS11655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="85"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1948515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="290" mass="31791" checksum="D6B6A1108E09F937" modified="2024-05-29" version="1">MLMLTTTRTYCILCTLILSQTLVFGLLSQNPRALLLQPLINENLSFSSQKSSNDDNGPRVEDQSSWYSVDPNDLTGGQLYSLCISSVVPRPVAVISTRSSSGVVNCAPFSYTGLLSHDPPTVAHGIGLKRGKDGMEKKDTLTNIEETKEWVFNLLTTEYLSEANQCAANFAPGEDETQLVEGTLTTLPCDKVQPPRLEQAAVSMECQLVETKEMKNDDGDHTTTIVIGRVVQFHIRKDVLVPMAEDDDSPPQWIVDLQKLQAVGRAGGVTYWPVGMAEDGTGSLEMKRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ14</accession>
    <name>A0AAD2FQ14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="90" mass="9633" checksum="7110185E3943C4DA" modified="2024-05-29" version="1">MAKLKGVVFVDARGHEEIAEASLDKPFVHGNFILRGEMEHVHQILPSKSAPIIVFCKMGGRAAKVKAGLEAEGYTNVLNAGGLGDVDFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRT5</accession>
    <name>A0AAD2FRT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositol 2-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS12400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRT5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="152"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1950057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39631" checksum="6FA173349B15AA53" modified="2024-05-29" version="1">MPPSSASTPPPEKVKVAVFGSGRMGTIRSQLLYANPKMELVGIVDTASTNNENPAQFLASSLETEAYSSLSDLVVNNTSNQLDGIVCCTPTHTHASVVQEALELETTRGMFVEKPVDESASKIKSLFEHVKKDVSRNFQLCCGFQRRFDPSYQDLLETVRSGAIGKPLNINIFFGDHPVPDLEFLKEGGGIFMDLSAHDVDFVLQVMGQNQETGITGADIVESVFASGTSSVPELDEIGVHDNATMTMKFQSGSVATIFMSRSASYGYDQRCEIFGTEGLCQVENIKETSVVLSNKDGIHQSKYLHSFPQRFEKAFGIEMDIFADVLLGQHAWPITEDDCIRVQKIADAAQESCRTGQLVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSD2</accession>
    <name>A0AAD2FSD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSD2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40970" checksum="93A2233D20E054EF" modified="2024-05-29" version="1">MAKLSVDDREKVYNDVHGIPDDCVEETPELIHNSLWGLQHEIDILPDKKAYNIAERLNPKYTQDRDFRLAFLRCEKFDCQKAALRFVRHFQMKLALFGQDKLVRDITQDDLDMDEMEILHLSNGRFLDAYDRSGRVIAIVVMVKKTYKTDSCLRKGFYNTMAAYRDTEIQRRGLVNVTIQFGTEIQGTSSDNPDLVWKLPKQIEAFPLWVSAIHLCYTKEAWEAHNAIVKTALNKQSRVRCRVHCCGTILECLEELRGYGIDPSSLPVNNKGEITDRIKDHKRLEQQRRQERLRYPTPTAIAVPFCEDVLLGKGTPFQIHRGNKKLQQFVADRYKEVRKGAKRGKENCCSRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSF8</accession>
    <name>A0AAD2FSF8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001789">
        <property type="protein sequence ID" value="CAJ1951591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSF8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="978" mass="110758" checksum="D3F2E3736B9E0DF2" modified="2024-05-29" version="1" fragment="single">RTTSSGKVPWSPKLQGFWDRLSLWKLLLKGRKRCRVSSQKVRRLMKKARLCTAWKKTTAELEVALAAEQRAYKQAKRQATQLRLYFLKSQKAHNRFLRLRRMKQREEARRRRRAQQKGSTGGLRAIQMEEQLPDGTPQLRTITDRALVEEGCMQENAARYDQTRAPYTTPPMAEPLYTAFTGAQAEANSIALLEGRYSLPDLLDPATTAFLSHCRFHKDHVPVHLEVTTSDHVYFWSRNPEDKGSEPHGLHNGHFKTAAQSPVIASCDALFRNIPLATGFVPSNWRNLMNFAIEKKAGDFRLSKMRTIQLMNSEAQANNKKAGRAAMQYAEEHSLIPDGQCGSRKRHQAIDLALSKRLVWDLLILQRRAAGWISNDAKSCFDRIVHWVAIITMLRFGLTWRVLSSMFNMLSSATHRVRTGFGDSERTFKPPSVIPFQGCGQGNGAGPPIWISVSSVLITMMEAMGYGFECLSALESQLVTAQCFCFVDDTDVIEAGNTVHHSGEAIYASVQEAATLWAGGIRATGGAINPEKSFWWLIDFEWDSRTGKWKFRGKKAVAPDFELQIQGLSGATESLRRLEPDDSERTLGVMLSPLENLEAHKAQLVAKAKDWAEQLRPNLLHKYDVLPLIKSTIMKKLEYPMALTTLDAQQWTDIMSPVLQVCLPKAGVCRNFPGDVVFAPLSYQGLGLPHPFGCQVFKHLEMLLRHMANRTKTGDYMEANVQAHQLETGMSFGLLQQVYTNTAILASDTWMKRVWHELKGLDIYVAYDSPALSHRRTDDSLLMDLFINLEVEQEELLWLNWCRMFLQVCTVSDIVTADGRFIRRSAWNGLRDECCRSPYQWPRTVRPTRQHWDLWQTTLSRALLASNGPHYQLQQPLGPWTDRLEDWNWLLSPTTGLFHRHGATWKHFCSEGSHTTSRRYAPGPSLPSCPWWTAPLPADVLRATVHSITGSDRVLLTGTGRAFEPSACSLLFSCFGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSR6</accession>
    <name>A0AAD2FSR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS13497</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="162"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="292"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="308"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="381"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="9">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1952328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="483" mass="54454" checksum="0BA904C2BD9D9D8F" modified="2024-05-29" version="1">MPIDINELRDYKGGDPAKYRKYMEQRFKPAEWVDEVVAKDEEWRNLVNEVDELKKKKNWIQKEKITPKKKAKENCDEEVAEMKGIVVQIKDKEALLPGIAAERDQLLNRIGNIVDPEVPISDDEDKDNLVITLHPTPPEGEGILPASQGSLEYTLPATKPMTHDELLWRIGGYEPQRGQQVAGHRAYFLTNAGVLLNQAIINYSISFLGARGYNVLQPPFFMNKDVMSSIAQLEDFDEQLYKVSGKTDDPDGATEKYLIATSEQPICAYHKDEWIEKKDLPIRYAGISTCFRKEAGSSGKDIRGIFRVHQFEKVEQFCLTIDDLEESQAEQKRMLQAAKEFYESLGFSYRVVCLVSHELNDAAVKKYDLEAWFPGQQAYRELVSCSNCTDYQARGVGVRCGQKGGAKGDMTARASFCHMLNATLCATGRGICCLLETHQTPEGVVVPEPLRPYMGGKDFLPFVRGPPELTKGEKGKLKGKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT34</accession>
    <name>A0AAD2FT34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001771">
        <property type="protein sequence ID" value="CAJ1950921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="66177" checksum="8A86C564BA986EAE" modified="2024-05-29" version="1">MKPGELQRVMSDKLAVVPATKRTPPPPQQEVKQHELTLNGITYRSVNNHTIIYSIQKVNTRKHLALIDRGANGGIAGDDARIIHKSNCTVDVQGIDNHQVTDIPIVTLAGLIHTQRGPAIAIMHQQAYIGKGQSILSSGQMEHFKIVVDDKSTKVGGQQRLTTPDGFVLPLDIRNGLPYLQMRPPTDRELSNPDIPHVVLTSDTDWDPSVLDHSIEDMEEWAKSVPDYDSEDEERPFDLVGVLKNNKAVTSFKESKLDETIDYFENFNCVLPTDGLYKQHHRACEDLTWFECNMADLFGFGAAPEDSPIPECFEVYEACKRPSVLFDPGQPVNYDIESAPLEANSFKDLILDSDKPTLRRSPRHKARKTPHGESGRPPPPRVHFDDTLTDAPPVYATAGPKTKKRQRNWEKLRQYFAWLPKLVIQKTFDCTTQFARIPMSAHLQRHFRLPFPALNVQRRDKPVATDTVFADTPDIEHGHIAAQFFVGTRSLVSDLYGVSTDGQFLQTLQDNVRKRGAPTKLVSDRARAQTSKAVQDYLRWLFIDDWQSELHRQKQNPAERRYQDIKRLANRVIDRTGAPPSLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT86</accession>
    <name>A0AAD2FT86_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT86"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1952454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="383" mass="42320" checksum="300530F2ACA38E84" modified="2024-05-29" version="1">MAGVKLIDVEQYLKDTIAAVDPSFQLTVSEVHRKGMMRALLGISKVKMDEDLRNLSAAIEWGKAEKFLREELNGFEPPQGAPQFQGGLEIYESFAPNAAKLFSYLARGRAYKGQMDLLLQDVRPDLSPIFHEVVGAVDEEHLLEAYALQQDPAQQELLLMCVKKELVLNSSDSSDCGKSKGAKGESSLKEFLSHEHSKERVLHNTFITTKHKNAMSKKCPYVIQLPKSFDVNGMTTELDAVVLAPFNDGDETMTIDWVWEAKATLHPVTLYDALSKKFSAISTIFAQANAKLYIKGEEYSIHATGLPRIGVFGSKILSPSAAARRSQLLTCEVMLSTSPEAVKEALDTGRITVSHEKLMADLNACLLLTQKVKPKVYVASLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU12</accession>
    <name>A0AAD2FU12_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU12"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47908">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47908:SF2">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042196306" evidence="1">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="25542" checksum="9BAE2FB3654A6778" modified="2024-05-29" version="1">MLRSILLSIIFVGAANGLLPSSPSTLNVRPRTRLFLAGGPNRQNIFEGMDLFRKGDIQGSIDKFDASVPPGSSAYLWQRGISYYYNDDFANGSKQFRDDVLQSPLDVEEIVWDAACLLRMDPETFPPKNVMSLPKGKSDRRPIMSIVYKLFRGEATEHDLADAGHKGGPSEEFYSLLYLGLFCEARGELSKAESYMRSAAKTKYAEVVGSRDYMVDVVKVHCSLRHWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU77</accession>
    <name>A0AAD2FU77_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS14072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF507">
        <property type="entry name" value="CBL-INTERACTING SERINE_THREONINE-PROTEIN KINASE 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="454"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1953472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="866" mass="95730" checksum="4CC6FCC3F9F7DE27" modified="2024-05-29" version="1">MATIASSPNGNPPTPTKKWKRFSMGKKKMQDPPKEADNGVGRSLSASRSQRKKGGIMRKLRGSKKDEELEGTTSFNHTESSPSNPQSPSERSIRSVESEIGNNGNNKVNAANANWPDTAEERQQRDFISQKQHMKERDGFCRPVDTYDGSVITVDKKPTYEIGNYRGGGVAGVVYEGHRLRPLSEYPIRRGVVEQKKVELSDAGEGETMGFFCAPEACGGVEDVKDDLTVDNNAEISNEDDVQQPKSSSKTSKTQGDSELAIEANKTGVMLDGQDAPSRSAHYTRAASMQMGGNQDQSLHHGLTEEAVAIKILNPVGYRILQAEGLKGVVVVKKGDDMESDVKKGKKPMESRHVWWLVNPNSRNLRTLQRYSGQNEQSSIQVDRGNAEKGLRLSLIAAYIDPRTNQLRELTLTRCIEIWGHIPFNATDSEFEETMSAIERVNAGQPPLSTAGDEMPPSRVGTDTSGLSKNDDDMKPFPLDQTRTGLMRAAYTERVTVHCEELNAYIAIPAVPSKYLRWLRQRRAATKEVRNMMLIGRHPNVLHLFEVLEFIQESKSTMFLILELVNGGELFDLISSSAGAKGSTDDESERMMRRFFYELASGIQYCHKSGIAHRDLKPENLLVHNKENGTTSLKIADFGLSSTFGPNADPNVKVMVEEDALVTPPPQPVLKPSGNPFSIVVDQSLCALQFLTCGTMDDLCAANDLDDGPSPLRRMTSVVGSPHYVAPEIISQSDESKKVNGRSSGLGYDGSKADVWSAGVILYAMLFKSLPFGEDLLRCPRFQSYKKWYDGIRQEGGRRSSPEAALAPIVSEAEERDFLGPHWFFPADTSKESRDLIVAMLNPKASDRLSVDQVILHDWLQAEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUC2</accession>
    <name>A0AAD2FUC2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001831">
        <property type="protein sequence ID" value="CAJ1953547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="254" mass="28587" checksum="4226927B5C3DF0A4" modified="2024-05-29" version="1">MYHDMLPGNCSKVNDENDPGQIRKRKLALFRSFPIDWQGDFNNSRNDPANDNNIMWKDIVSWMTEKKRTVDRKRLMQESSPRRTRPGNRTGGRGLHHNGFRGGRGHGRPSNGYQPYPSPSSSPRYSQGTSQSFQRGGNSQQQNQGRFQPRHPNNGGRGRGFNGQHGGRSQSGRFQPGQNYQGRGQSHQQNSQNLYAELHYNQEAEGFAGSGMEPRRNVLWRNAKCRAVPASGTILSIGGEVLIKNTDGRKLDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUN2</accession>
    <name>A0AAD2FUN2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001844">
        <property type="protein sequence ID" value="CAJ1953830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUN2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="28239" checksum="087B40A1774CBA3E" modified="2024-05-29" version="1">MMQIKAKFDTDKGLNFIQQCYIYQGLKKFGDDGKDAVDKELRQMLLRDCFTPEFVKDMTASEQKKAQSAMMLLAEKQFEKTIKGPLVYRGNGTCEWLSQEDTVSPTALQEAITTTCVIDAHEGRDIMMMDVSNAFIQTYMPEAKEGEDRIYMKITGMMVQILIDMAPEYRKYVVLENGKRVIYVRVLRAIYGMLQSSLLFYNQFQSDLETKGFVFNPYDPCVANKVVDEKQQTIRLLVKWDLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUN3</accession>
    <name>A0AAD2FUN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUN3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="173" mass="19825" checksum="8B9B4B14D5AE1D5D" modified="2024-05-29" version="1">MDRFLWSHLMQLIYKMRAQVRMHNMRVAESYPSALGITLPPECQAFVTYLFPFEDEDKGWDGRIPKWYKTLDLDSGTEVPDSYLQYTPRPLPSSAQDPDNYVTQRLTLPQKAPAAALPPMDDDLAEFIQATKRHKPNSRRSLVHLQVTPAPEDSFVLTEEGNFEDGHGTNYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUQ5</accession>
    <name>A0AAD2FUQ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS14251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="716"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1080"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1953648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1102" mass="124605" checksum="4202AC79DE9FCCE2" modified="2024-05-29" version="1">MHARKPSYANAVANVVSSTSSWGMGGKPPTLESQVKELSHPAPTSLTLTAALYLLAPLKESSDVYLMTRSYMQNWLIWAYNQNVPKMEKQRVQTAIRLAATRLGLQPPAVSFKYSDPGPVDNSSLSLEGFPLLLDPHVTVLDLMSDNAISGIKSPKKSNIGPRARSLPISPGYTNGSDEFEAQPTDEDLDRDGDQILCCAVPAKFYELLRSTIGISCVNGRDITFQPFVQEEGPYQGALIHHHAMASYNGEKETPAPMSRNDPSFQMNGIGKSPCRPLEFRRKIIMKRKLKRLTSGEIDESSPMTRLLKEEEQRAAPELVPTAEVWPVKLQYSVIDGNNMRRKEGFVLVSETTRVYDALFWLMKVAAPNTSSSCKRIWSKRDTTGTASGDGYELIDPNLLDGTIEKEPEKEKEFQPPRKKVGEWLRSHYYEYTKRDCDIIIEVGKPNEKWLRTSLELQNRIQVGDFVDAQDAGGNWYESIVKEVNDDTITVHFFGWASRWNGRIRRRQDSPVPANIAKLHCAAPLWSHSSRWRERIAEGAIVEVRSASSKVDRPKWYKGIVKRIGQQRVVMKKVTGGAPLEMIVGKDGKRKPLLLLNRVQQILVEVPQELDKLEDEEEEEDLARKLRDDVSIDTMTTMDTFKPQPPFLRWVNLYGEEICEFGTHMKSNDVPNIATLQYEVESHRKPVEILKSFNNMYGQGFMKESLRGTPPAPGSVGMHNLGNSCFINSIVQCLNHMEPLTKYFLNGDYAKELNRKNPLGSGGRVATAYASMLKEIWSNKYSALAPRMLKQTVASFAPQFNNSYQHDSQEFCQFLMDGLHEDCNRVKEKPYVEELEGIGLKDTTAAIEAWRKHLLRHDSIIVDRCQGMHRSHLTCPKCGKESVKFDAFSTISLPLTADKSNINGMTLQDCVDKFLEGEQLDELNAWYCPGCKKHVCALKMIALWSVPDILILHLKRFQFDHCAVRNDVIRSKINDTVRFPIERLDLRKHVLGPTYDDAPPIYRLCGVSEHMGPTANSGHYTATVRNCKDSRWYRYNDAHVGETTADAAVTGGAYLLFYERLKGSARWGGMEKLMNDRNVEPYAGPEADQDGFTPVKSRKKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV70</accession>
    <name>A0AAD2FV70_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001845">
        <property type="protein sequence ID" value="CAJ1953834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV70"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="179" mass="20368" checksum="D15B5CAB88E8CD45" modified="2024-05-29" version="1">MKKSADAEYDFLDFWEANQKFFAMKQGTTENLMHFKERFLRQAEVLHDLYGVAWFQDFAVIASTDTAAQNKFKDDIFEAVLATGFLCNSDQTRTAPLMLDLQTNYCRDVDYYPKMVSKAQDMLKIHMEMSKNPGVNLYQGKDQPNKGKGKGKGKGKPRDGKKAACYVCGNNDHSNTHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW40</accession>
    <name>A0AAD2FW40_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="247" mass="28169" checksum="96B53326EE4C09B1" modified="2024-05-29" version="1">MAKKKTQGTKAGKRVASKKPVAKNKTSTAKPSSNNMNDWISSLAKEATSSESTKVMSKEDRIRKRAAKKAKRQEAQELKQQSQSSNSMANSKPAAAPVSQQKIQAAFTKRRMRQLVTILETVRNNYNQRSKKDLPRPFEAPAFKKRKTKGWSKDTIQPRTSDYAGIGLARDSLFISFKEPSFFPSLEEEFKEHIPGFFGKQRTKAMKRQLDKDMLWKKMADKDKMNKKFKNMTPDQRVEAMLEAGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWP1</accession>
    <name>A0AAD2FWP1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF58">
        <property type="entry name" value="SOUL HEME-BINDING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041954280" evidence="3">
        <location>
            <begin position="20"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1955183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="442" mass="49027" checksum="25C05A1E981F965B" modified="2024-05-29" version="1">MAPSLSFLLSISLIIQGQGFSSSSTGIIQKNREAESFLRSSNDAAFSAFADSLEEEPESNKEQPWQEKLEDLLDPQTNLADRQILMSELLNSNEEIRESVLDALARRKIDPLLTPTGKRIQDGTRAVVRQLANDILPQLSKSPPKFPPTPQSMEKVGSRLLSVVTSQLQKNIEDLQEDLTDPINRIPQRLSRQAEDFVKEARNVFLEKPEGLQEPSYNVVESRDLYDIRDYESYKVASTQMEEGEDLASTGTAFNSLAAYLFGLNDESRTMAMTTPVTTTSSNEMRFFLTEASIPQPQPESSVEIIDIPSSLLAVRKFTGFVTEGEIARQKDALLQALEMDGVELDVAHGAVVPHIIFQYNPPYTLPIVRRNEIAVPVRLGVDLSGGTSLQQEWSVDATVGEDTVIGEENVKMKVNSRTEAVAEKDNDENDEVSDDDTSPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWP2</accession>
    <name>A0AAD2FWP2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001848">
        <property type="protein sequence ID" value="CAJ1954027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="14026" checksum="5370731C82CDAE03" modified="2024-05-29" version="1">MPELTVRFQGDSGDEGNEEEEPIVADLDHHQENVSRGTDDIGSLVTDLEDLQEPPEEEIVFEPETPQVAKVTRSGQTYAQAAMSGLNLSQVPKRPREWPSSRSGSSDNKNKKRVATRRKHQERES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXP4</accession>
    <name>A0AAD2FXP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXP4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050343">
        <property type="entry name" value="RsuA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00093">
        <property type="entry name" value="pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47683">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47683:SF2">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="125"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1955655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="339" mass="37737" checksum="C3E51B1FC8F930AC" modified="2024-05-29" version="1">MFACTHQFGPLSRMATRHCGRKVPFSAISASRSCGYGTTTTSLQMASKKNKNAPDKLFRADRVLANRGVGSRSECFELLKQKRIFQKIDSSMQRVKGPSEKLSMTASLFIDGKNEVPKPLPLLRVYHKPKWVLSVMNDNKGRPTVGDLDFLGGSANGKSKMHPVGRLDYDTSGLLLFSSDGKLTQQLLHPNHEIEKEYVALVVGQVDADVLKEKLAQGVTTSMGAFPADLLEAKSIPKEEVKETIDGILKNLPEEYDMERLEEKGYLFFKDATELSEVRLVVREGKHRMVRRILANSGYPVIGLKRERLGDVLLGDLPAGEYRELSGAEEKWANKVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYD0</accession>
    <name>A0AAD2FYD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="99"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="298" mass="34022" checksum="CF472DE4D511568D" modified="2024-05-29" version="1">MTAIILPKLFGKHNTAHSKDDCSNSHTTSSLASNAYDEMMGLLGTSQQAEAQCIAEIKDSFRKFGIRLPHEKVFRYASFYNYNAEEAIDRIREDNGNPYMQLKMKEDLQDQFGSTNALFPLPDLRTRKTNSEVIYMNPARFNPNQDDIDTFIDSLCYVLNDLSQTVDQCQNGVTVIANMKDVTMENFNKEYCAKLMQALQGDMVPTNVDAFLIVSPPSWFGKVFKWMKSSKKTSKDFLKRVHQLKEEEDLSPYLMSQPELYLPDGLCGGHAVGAELCEDYMDLKIAQEQRQQEDARKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G043</accession>
    <name>A0AAD2G043_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MEMO1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G043"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34942" checksum="9C8572D04B2812F5" modified="2024-05-29" version="1">MKKSKAGYSRRAAHAGSWYTNKGHHLKQELTSMIQQAAALSTEASSSMRPLKAVICPHAGFSYSGSTAAYSYKRVQDELEQNPSITSVLVLHPSHHVYLDGCAVSGAILLETPLGNLTVDGNLRDELLETGKFSVMEQSVDENEHSGEMQYPFLALAAQVANCLERIQVLPVMVGSISGKSEAFFGKILAPFIARPNVLCVVSSDFMHWGSRFGYQPTIVCKPIHEHISELDKRGMDLIQDQEPEAFAKYLKETKNTICGRHPISVWLQAVQVNSSSQVETLDISFIKYAQSSQVMSLRDSSVSYASAIALQQQQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2E2</accession>
    <name>A0AAD2G2E2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001995">
        <property type="protein sequence ID" value="CAJ1959430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2E2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="474"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="584" mass="65285" checksum="0ED53E0C86A53E08" modified="2024-05-29" version="1">MSSEYSSTIHLTQEELQQDVQISVSDAQEWTAEIPFIGLCDYDDNESVDLFLFITNGPKFTQAQFNPDHWPPTNADSYNGTLRCARNRKYANKEKNKDEYDAQGVCFGPCHKSHHHDRKRNRVNGQTKPRATQTAKDTTGNCLCNCRLSLKFSRNEEFIYLACKGEKIHKYHPKAPGPLPLKANNLTDEQKQQLLAQQRAAVANPQSRKILLELKQGYISKSAYRTVMITAPDYIAAKAVAGANSSAAEFIGWLRAQAANPETNLSYMVLSYALTSKNCCVVRRYIQNPKGWRSNSNPPSNPETVMNNLTYRDELLLPIEIQEPLASSRKSTPTPPIANEVDNQTIRNSLAYTSGDGKESCDEDTGSSHMDCNAAQGKVGIADKLCAKPAPIVPKGLYSIANVSIANQTNDNFAQSVEVESTLKGVAPMVELVEQAETHLLASSDTIMSPTKVMLGGAWMTEAEKRHFFRFPEVLFIDATHKSNNKGRPLLLVCGRDSGGKAFVILQMFMPNKTKAFYWWVFLEVSPAMLGVAHLKRVNLILTDGNANKYNALDQGIFHYFKNAIRWRCGHHLIEKTHQITRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2E3</accession>
    <name>A0AAD2G2E3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2E3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042113050" evidence="2">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="127" mass="12497" checksum="F4F78328A8292ED1" modified="2024-05-29" version="1">MKLSFIAISFYLLAVDAASLRGVRKLSSGSLPSLSGASDASGDSVSVSSGSNSRKLSSASVASVSGDSVSVSSGNSRKLSSASVASVSGDSISVSSSSSRRKLSSASVASMTSGESASSSTDNSRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2G2</accession>
    <name>A0AAD2G2G2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2G2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041903087" evidence="3">
        <location>
            <begin position="33"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="924" mass="100158" checksum="B3F73D215ACFE731" modified="2024-05-29" version="1">MKPMRRMSKAAFLSFVFIAFVVTTASWHSVHAQVMCPVVKRKVADSLLDKEDPNGPGFREISGLAFSPSQRHNNRPIFFGISDGGGGQRIGLFDSRTGDRLMTLRVSSDFFSNRDWESLTIGSCGKSGVDQTCLYIMDAGDNEARATSGNRGRGSYHVVKIREPRLGEYNDNDRIPTSRMSKLTFYYDHSSSPTNHADCEAMFLDHKGWGDDEAVGDIYLATKWDRENQFRYNRLFHIPASAWSSRLEGNVRFYSPRAIGRYDFEQYENNGGIHIMKRTWTGAEMSMDGTMIGLGNAVRTFVFLRCPGTSVWSAMANPDNRSRACVDWTHPVAGQIETFAWAPDSQRTLSIPEANNPRLGWTELTYNAGDSSKVCTTSLTRPPTRPPTPPPTGRPTRPPTRPPTRRPTPQPTRRPTPSPTPQPTPPPTPQPTRPPTREPTRRPTRNPTPGPTPDPTPGPTRPPTRNPTPGPTREPTPGPTRPPTRNPTPGPTREPTPGPTRPPTRNPTPGPTPKPSPGPTRPPTPGPTMLPTMSDMPSILPSDSPSSEPTTAEPTIQPSAIPSIEPTTAGPTRLPSIMPSGAPTTTAPTITASSNPSESPTTPKPTMSPTSGIFIPTDNPSLVPTVMPSSVPSSTPTDAPSSSPSNVFSGSPSIATPMPSLAPTPMPSLVPTQTPSLLPTNKPSAFPTRGLDDTLTIDIMTEQPTATIDPVNTSESDNGDVSGQEEEKQCFGICPPGIALINPGKRVDIERDEISCSAIEKVYRDQWGANNVCDALAIRARRAGCLCGQNQLELDLGTSSDITETGYTAILAAATAFLLIIFAGVRICLYKHGEEDKNSEVEVNGNRIGDDGLSGIAGIGKSKRIFENEEGREGRKSYSQSWTLWMRQYERRGGTSVAGTFDDTTVAGRFNWGKNASGRNNEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2V1</accession>
    <name>A0AAD2G2V1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002065">
        <property type="protein sequence ID" value="CAJ1960579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2V1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="159" mass="17763" checksum="4CD2CD1D70B9AC1A" modified="2024-05-29" version="1">MSTNCPRNNKHTTNLDKDYPGQGIEIKTFKEFVGVKIIGATEGSFGNFIGITSYFRTRNAYAHGGSTVLHAFNELGLEWQVLPSDGKLFHEIAKPQFPELCYLPEDPRGEHARRLTESHISREAAKAACAGHKDEFDLKGCVCVNICRQLLGRRRDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G609</accession>
    <name>A0AAD2G609_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G609"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="149"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1964285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="361" mass="35920" checksum="DBEC7E1D59215246" modified="2024-05-29" version="1">MADRSRSRSRSPDRGAPADAPPADAPHDSGPPADGGAPAPDGGGEEVKLYVGNLDYATDEGRLREEFSQFGTVTEVFLPTERGTSRPRGFGFVTLASREGAEKAISKMDQAQLDGRQIRVNESRPKGERRPGIGPGGAGTFNPAGKEEVKLYVGNLSFDTREEDIKGMFEEYGTVSDCFMPTDRDTGKVRGFCFVTMPSADAEVACAKLNGQEVDGRALRVNEAQPRGGGGGGGGGRGGGGYGDRGGGGGYGGGGGYGGGGGYGGGGYGGGGGGGYDRGGYGGGGGYDRGGGGGYDRGSGGYDDGGRGGGRGGYDDRGGYGGRGGGGYSGGGGGEKSYDDYRGGGGGGYSGGGGGYGGDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6T5</accession>
    <name>A0AAD2G6T5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6T5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="380" mass="41825" checksum="CE1C2320B3B2E3AF" modified="2024-05-29" version="1">MGSSAKSIASEKSNESMSAKIRAAKMAKKRIEGVLEKKMRLASMLNRRAFLRRFGSSMSMEATLDSMEMELSSFEKAIGREILGPSADGKLPFSFDLAARKGSDQNKKTAGEKESRNLHADEGENQETLSVQSKSNETLGSTHGNQSVTTRKASNLVSSNRVYSLPEVDENDESDHSGYSDSDSSVSDDEESAVAPQIEYKESNVDINTSGPFRWYDRFVREGDFCIDYACRVIECDPTATYANAQLAVAGFTHLEGTGEVEPEEVQAKEEKLEEEKPKKRKSWFRGVPGLNKKGATTIELKNADAALEDLTDSDSWSSEEEIAVIDKSKLLSSSPEEYFATIGAAGASRRKKKSSNRAGDKDKEEVSRIERAGRVMCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7U4</accession>
    <name>A0AAD2G7U4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7U4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027591">
        <property type="entry name" value="CofD-rel_GAK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04357">
        <property type="entry name" value="CofD_rel_GAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="496" mass="55073" checksum="507F9B952B31042E" modified="2024-05-29" version="1">MEKDDGKRTEEGLQRQPRKKLKTAPQKQQKTPRELRFDSFADSMDRSSSESSEDEEEATPAVVPATEGLPPPPKRKRKFKPLLIPLSRTLTCPDMVRVDRCNRVPEYGPEILFFSGGSALRDLSGVLKDYTHNSIHLITPFDSGGSTAEIRRAFPISAVGDLRNRLIALSDQSALGNPAVINFFSMRLNEDSTKAHAEFESILQGKEPLVKAVKMPMRSLLRRHLQWFSNRMPTDFNLCGASIGNLIITGCWLEHDKDIVAALYILWNLLGVKGKVRPITGAHLHLRTQYDNGDEDVGQHLMGKRKPPQKIKSIDLVKSLEDGTTTTRQETKLCHLDFVSSELIASCDLVVFPMGSFFGSMLANLLPVGVGKAIHRCQAPKIYIPNTGVDPEMHGYTLSELITCIVSMVEDDLPRGVKEEDKPPEDDTVDPSDIVNFVLVDTENCHYCVPIDKEVIEAMGIVVMDMPLVNLEAAKHSKSPTIDPTKLAQVLLTLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9F8</accession>
    <name>A0AAD2G9F8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9F8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041983953" evidence="7">
        <location>
            <begin position="27"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="349" mass="39077" checksum="6A7FCE1FE662E371" modified="2024-05-29" version="1">MRLVRCFMLSFVLIKALDCLVPSAAAQPTVEEMPSNSPIHPTSIVNASYDTRFNQSEDDASSFEQDRISPLWFCFVLAPLIYFAYQSYLNTERISTFLKPSHDSSIPFASSVGTMALLCAVVLAQISFDQSSIVSSCTFFSTWYMQKLEANPLVTNCLTSAVFTWVGDVIAQGFGEMIHSDKSFFENYDKRRGFAFILDGIILSGPLLHYSFELMESIFPTEGEDGTILSSIIHVFLTDYVVDTIYIFLSFVLVAMVEGEVHDLKKILRQNFLSTVKASGFTNLSLAPFEFVCFRYLSVGYRVLVMNMIDVIWQAVVSFFAHRGRKHAHQDPVDYEGDKASLIAPTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAY1</accession>
    <name>A0AAD2GAY1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002356">
        <property type="protein sequence ID" value="CAJ1967944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="311" mass="34007" checksum="696F49F9E15416D6" modified="2024-05-29" version="1" fragment="single">MGISTFFCCTSLVVVDLQEGLQKIGSMGFAECTSLVTIAMPSSVSTIAARAFEKCTGLVEAYLPNEGSLTKLDEGLFASCCCLVESIQIPSSVQVIRREALVGCTSLVQVDFPNVLRTIEALAFWKCHSIKDLGTPLPPTVETIEYLTFSECHRLTEVSLPQGLKVVNVECFRECALLEKVYLPASVTHIMERAFMGCASLSDVHLVEGLQVIEEGAFEDCVSLAAIQIPSTVESVSYEAFSNCQSLICIEISSSSSVELCDGALVGCQSLVNICLPKTNKDEKYSYLESWRFHGCPLLQQQYDCWLLGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBI6</accession>
    <name>A0AAD2GBI6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="546" mass="61110" checksum="58BAED5403E13B10" modified="2024-05-29" version="1">MMGSYIEGPSEQWLTQFPTILIVTSSMVIDRSLRKDLIEERVRCQIWLWFCVILSLRSHPSSLHDKDIQQHGKKEDLIFETWMHLVIVSNLVSIGVLAISGPLERIKKSYNRSSWWFSFAAWTAMMSSSCLFSSLRYAEGAQESIAMFSLQVYILSLCILWIIHWYKRRKEKLEQEMRKITNYGGSGSNTNPSSSFIISQDKDGFDRSKWYTWKPSTTLRWISQVLESSFDHDDVDHGVLQQLASHRIDGPLLDTLSVSQLLQLQVPYGPACHLDQAIQTELVRPFPKPRGSEANMSGSSCNGASFGGTTSAHPNDFLSGFDEEYNSDRRRSFASTAKSDGTSGLADRNSFASGAEMLNLDPNQENHINDVMKERYGLELPRLRTEGTSASDPASGAPPSQASAVSDGEDPLQRGPIQKQLQSAALPTPKIAPAPAAPAIHTPSSAQASSVGGKSEIPEAILKQMPANIQDIAKRRPDLVRQMLLSKQLQVQDQKFQREDQLYTHAEEGAHDGNEDYGNDDEDSTDETSRLLRRRKDHRQYKSTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCE4</accession>
    <name>A0AAD2GCE4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002447">
        <property type="protein sequence ID" value="CAJ1970004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCE4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052596">
        <property type="entry name" value="AMBRA1_autophagy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874:SF1">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="682" mass="74539" checksum="32ADB6B3D51BD1D3" modified="2024-05-29" version="1">MPPPSPSSVRWHYDNRGFPHKPLLEDPAIRSQIPSTAEMKRRWDFRNAIQEESNQHRRVYTKPDFVGHSVTQLLNRRSTYGSSRIGTKRLRHFAEYTSVTQYQSSFLAHLGGQDEVVNGQREQSSQAVSSISVAFSPCGSTMASTHGDHTVKITDCNSGGLLQTLVGHSRTPWTCKYHPLRSDIVASGCLGHQVRLWNWKKNTCLAMIRLEYAIISLSFHPSGKVLGVANGTKLNFWGLGDLDNWSEGGGAQSGGGDTRVLGMLTEVDQGHMLRCVHFPPAGTTVIVGGVNKPDTNQQNSRPMRGGISGGGMTFYLKLFDFNLPMTVDRQSRQQFSSTRTRARALENPRVFVPRALLYNDGGFDVSPDGKTLCACAEYWLPDGVNNAMELLEYQNEQDYDDDDDDSTDGDGSGSPKKPQNDTPTSTTAGPPFSPTLNKGSLQRNADSSPPRGNTTPRIQYPSMNAGSNPLRTPTPQTPPAKQGQMTLSPPSPPGRRFGKGYGMQPGRYVPHVVTISLDTTPSDSIEQDQLQAMLYPPPAAVLPNSAAAAAATATRNKKQKTPRRGTAKLRPRLGQLLQACPLDGAKASAVTCVKFSPSTNFCLIGYGVREPIMEGNPTLPLHPVTALYATSPKMTHVSTMLSPDDDVNIARFHPHSGVGFCYGTKQGRLRVLGPRPWNYYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHD2</accession>
    <name>A0AAD2JHD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS12755</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHD2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042053416" description="ATP-dependent RNA helicase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="179"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="447"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="10">
        <location>
            <begin position="633"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1950784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="666" mass="73187" checksum="408B28C126D4C534" modified="2024-05-29" version="1">MTSHVLFVIFFVHTIILNLSCAFSTSNGEKRWSKLSTSTNSQKWKRGTQASNKKRKGYDLRSKRGVRTGRKKPPRWETEGDALFFVSKSDGSVPEVPGETPTEMLNNLMKMKQKLQSEKKKPGKKQPAAPAKDEDEDDDSQKKSLPPHMVWGTLSTGPILSPKLKTLYDTPTAIQTESFGPITSRQNVVIAAATGSGKSLAYLLPLMCRVSRKKFGSVMVVTPSLELAKQIKSVVDGIWTPTKDIPGSSVCIITSDLFDEGSTGFVPDEEVLNTPIIVGTAGALLKWLEFSIKSRKGRRVLENLETLVLDEADRIMQTEAMARIENDTRNGNGGTDLWERKKRLQKSDAISLFDTIASQGRSFFVKSRNHIQLICASATVGRTLRRQVMELTDATTVEMGSVLVCADSRVGKDADERRSSLLPTTIKHMYMIQEEGAEREGAAMIKEVWQVMKQLPPGPTLVFPGRTGVQLTADTLLTDCGMQHTITLRDDIRESSKALDLEKADTQHNSWEETPVFVVSEKLARGLDIPNVAYVVLAGGAPNSPAAYAHLAGRTGRVGKEGKVLTFVRDMRGAQRVVSISFKLGLAFEPLSVAGGTPDSAESKSVVEMAEELEPEAGSIHEADSPTLLREELESYTVPTLKEMLKERGEKVSGIKAELVQRLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIX6</accession>
    <name>A0AAD2JIX6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="433" mass="48725" checksum="6BA38D0BE1FAF56F" modified="2024-05-29" version="1">MAATIKSEQEGSFLVEDSFSANIDLPIEAFQNEEDEIVQEFDVFLSPELANQMHLMQFPLQQAAFSSPDAARIKPQHCMMEVDYSTPENVGEHGGYQIATRSFVSHTIPVGTHMALGKMVNKPGFEGLHLVPLSRITQLRPTFKHVDEATISATATTEEDALNAEAELSSLGRKPLSFQKKESERAAMIRKSTYAYKRMSEESELWQNLNVHDCESMEAKSTMDKVTEGTSQHNLMTLTNPSSAAGPLNDEYIRTLNYLPGRNNEQENDGEVDAAAVVTKLVDLMQEGWPIPYKILKSQFSSSISENMLIEALASCAFLVRGNFVLQSKLLSFSQSIAHARTFVLFLFQTIEVVHRLRLEQVYEDDDEVTSEIILMLLKQVGRSTPEGWKLRVEDDPSFGINHPTAVVVHLSFWTSQLRRFQPLLDLYRQDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ84</accession>
    <name>A0AAD2JJ84_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001882">
        <property type="protein sequence ID" value="CAJ1955387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="204" mass="22802" checksum="5ABE123B2E1F900E" modified="2024-05-29" version="1">MHQIYYYYRSRRAGRRSRISGPSSGVSHASLDEYLRSLPAGDWSGNDHRRHSSLATRVCFQNVNGSPENGNDPKQQQINSWLKEERVGIALLAEAKTFWPSINEGHGWSDRLRQATMKSEQKGFYLSIAYNRHQDRSAATSAVQWGGCIATVLNQVAHRAKEAGRDPTSLGRWAYVCLQGRKLKAHGGNVQDSLLGCLQPPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK93</accession>
    <name>A0AAD2JK93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mechanosensitive ion channel MscS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS16822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="5">
        <location>
            <begin position="796"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1957662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113901" checksum="0B92352AE41E659B" modified="2024-05-29" version="1">MEEVPKTIAVMEGAHANDDTLQSSNIHGGHRRGNSNLSDLFDPPQQNSTSTAGQHHHPLKRGISMESDAKQTLAEAARLRMEHNRTEESETQKITLDSLLQNSHYEHEATTHILTALEDQLGSTQAFENTILESVSDDASKALEESNSGTKRPSSHSTSRRSEDQQTERKQVMSPKRRHHRVMSIDDQLANLADQLIDHGFHVGPNSTPPVAPHSEFDRNAQLAFGAPDFVLQSPEKKGGGNGTGAVLRDRLFSGDNHPTFLPPVDEGSPSELMNPHHQDNQASFDGVVDLETPKTSQNLPPQEAAKNSPSNRNRNRSSLSDMTDKVKNDVASWGSFFRPQQATLKKYIKLMLYIALPLVGVAGLLFYFLDNPTTTTSEGQSVSWILIFVVRLWVTLTLALAVQALVIDLLCVQTRIIPRLVGPLFTLWIVQSQGWPFVIFMWSILNFGMLYGQSAFAEHWLFWQDTIPLFSEANPAGNVVSSDLYRVILTICATVPVAVSVKRLAVGLFLGRQSFLHFGERLAKVMDKMLLISQVAKLASRMEKQRMLLHRRNVALGTPGQPKKKGMAAYQDIFDQDDGSSTRTGTVLGLVESEKNKLAQMLDQWEEPERRSTAHKKASIAAVLRFRNALALIHNDYPFSFAFGLANKRYECVESAQIVFKHLLSEGETDVEFETIASSLAVRDGGYLNPERVKNLIRVFRPNRDGTLSVLDFVKSVDAVYKEFRLLQASIENSAQIDLAFDAIFNTIFYAIVVVVIMSQLGLDPMALFLSLSSVFLAFAFVIGSAASKYFEGILFILLRRPYNIGDLICATNIQVEPGLMGNIGWYVQNVTLFETTITWLPTMETASVANGALASSRIVNWARSPNARFVIFLYFPIETKYETLTLFRGAIEEYMKARPREWLAFNALRVLNVFTDKGYIQMELVVQHREFWQNAGAVYDSRGNLVSFCNEIQKLLGMQFKKPPLPVDIRNGAALEALDAMGQERGPTIGAPDNNGGGTEQAARAKFRQTAETKHKMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL16</accession>
    <name>A0AAD2JL16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="393" mass="45997" checksum="8A106CA8E368DA3B" modified="2024-05-29" version="1">MTSTQDDTGSLKQCLLDDTVLEHVLPFLHAPELASVARTNRHFFQLVMNHDTLWASTYEHWNRKYRLAPLRVLTQDDFYDPDNFVRIEMRIPLRPRRWRTIGESANGDDGIGHDDCHDVNYYQSTVLSLQARQPRRYCHDENDANIDNTGGDCSKCLPTALEYSNDVETIDMYEDDKDDCPIYFMDHGVYCHWRVDEYGNLLDSPSGNSSQWSRREYPVLCEDCGVKLHTTEDLVNHCTSPLHIYCKCPVLLDPRRTADFEYLSRYEKAKAIWHYPKQAASFYRQLGHQPPNQYRMHQYFGLLEGTIAFVLQRDSIADSSKHLYPERTVQRVSDYCVEWIVHKALHYDFFNHAKQVAYAGWQAVDFYESGLGYDLCLFLTGIPDHHFDFLLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL61</accession>
    <name>A0AAD2JL61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002064">
        <property type="protein sequence ID" value="CAJ1960569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50074" checksum="3632CEA7231D8E4A" modified="2024-05-29" version="1">MAQDEGNILHQRKWGDCSNRLEGPTSGALWTPPSMERAPRHSSGGSFGDRERPLHLTKWRPQSRTMGGHGGFRASQTHRPKVIIESWRSDPTLWQYGPTSKPTTTRWREAGYNINCRTIKATAIGGAVTQERLLVVRTRIDCRAQWTWDSLDRDLSVIRPMGNLLTPPGLVPRNSYSQSGSAHTPHSLHDPMPNQIGAWIKTEKGVRRLMKEEVAQGLGIPKGCETELDQRPGTTITLDNDVFNWHPPDLSLGSPWHTLRLANLPWAADHYPEPDNIYWDGIQRLAVHRNNYNSEGPDPKRLQLLWWEFPSEHWGELRNGARQNFLKQPDPCLRPNAPMDEEMLEAAVQFVDELVELGVLPSIDEGLTVLTNAPLFVVGKDGQPGQWRVIADMLRGGQNDCVGQDPVFMPRIAHIVDQMYTEGYSAVVDLSKFFYNFPTHPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL98</accession>
    <name>A0AAD2JL98_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002075">
        <property type="protein sequence ID" value="CAJ1960855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="214" mass="24227" checksum="934773E7D6A688E1" modified="2024-05-29" version="1">MENAAFATMTAASHHKYEKNEKRSDRINKKSYWVNGSHVDETITYNQYTIDTAVLAPTTESPEIKQTILQQSVNSINQTKTTMEHKVDFLMKRYTSVCPDVRSRVNAATSELFDVTSDVYEFASLHVIDNTGQAIATGPGPGLPAPFRAAATYFRIELRLVPRLCSLRTDIGIDPTKFPPSSNRAVYVPVPRVQNQMDVWTKHFTRKSLQQWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLD1</accession>
    <name>A0AAD2JLD1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="749"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="854" mass="92067" checksum="F510D747A36ACCD4" modified="2024-05-29" version="1">MTTGSSEFQPAAAGVDAPADGGGTPSPLATSTTTANASDAVAATENAGGKPYPQERRSKSRRESHRHPRKSGTDGGDEQNHHHQHHHHSGGDGKEDHIENSGELTLPTRGGEETRKSSSSARPNYSKSGSSRRSSRRHQHTKEEGNPNTDVFLPLKDATDGEDAETKPRSRSRTRHKSRSDDNNNSGELKLPSNDGNTSGGDERTRRRSRSGSSRHRRTVGEEDEATPATTMVPLKDKSGGGGDNEDSRRRNRSHTRHRSRSRPPVDNDDGHEADRSGELGDRHSGRRRSRRDSRRRSSPHGTRKRSSSKRRKDSNNKRKSKSRKSKRQRAKDFISSSASLFSRSARSATSREKRRTAPMTAPAPLFGGVPDEYYTDDDTIASNQKQDDKQRTRDAMAPAPKPSCWVQAWQKRWFRVVLALVGIGLAILITYLVMKFTGLGMEDESTDNETQGNNGGKDIQSIPISPSPTPALTEAASLVPTAEVTPLYKYPPPNDAICRAFITGRPSGLIPGDVGFLGPGSITLDFDFNFDVVLSRMTSAQEEKWLEDFQDQIMVSLLPLLVGCLEDSTSNRRLKLDALPSLLRRSEGKSDMTLVQSTTTGHSRELQDSNQSEIRYVIQNAKVIDTVASKSPCPNNPRQNPADDPSCYLVTVIMELSLRGEERIFPVLSLLANILGEFAEVDEDGASGGGGNTLSSTLVEKVGLSTSLFQSLSVVGVQNRDPTNSPSISPSLAPSASPSSMPTPKPSQSPTISPSESPSTTPSTSPTDRPTGRPTPVPTRTPTKSPTDPPSRLPSSSPSRLPSNAPSRLPSVLPSMVPSGAPTKSVPPTKSMVPSSGPTDSLAPSSGPSATPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM42</accession>
    <name>A0AAD2JM42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1962123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042292538" evidence="1">
        <location>
            <begin position="30"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="216" mass="23488" checksum="0654A968BC488D28" modified="2024-05-29" version="1">MMTNNKTTQTLMASLISLVFLGMLQNVQSFQPVIGLGNSRPGILDEMTSSLFAGVVAPVREPTIIGDDLLIEDEEDDYDELVDGLTEKLEAMEGLWFSDDFYGKHGREWVQVSTRLVGASATSVMVAVKVTGDPHVPAGCVTWQTDSWPTEGGPSVSAQIQTRADPQDPDGFSWLPGELKLINQKQIILSCSHGPGLASTGTFHRQEEDDDEDSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNH5</accession>
    <name>A0AAD2JNH5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS22360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF11">
        <property type="entry name" value="ARYLSULFATASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042026797" description="Sulfatase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1966777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="549" mass="60871" checksum="0272DFD5CF5E25B3" modified="2024-05-29" version="1">MLLSLITSLLLTIATSNATEFPNLVILFADNLGYDDISVFQSKSNPQHTKTPNIDNLAVDGMKFLNWNSAAALCSASRSALLTGRYPVRTGVYPRVFRSDARFGLLPEETTLAEMLKGFGYATKIVGKWHLGHREPFLPTNQGFDSWLGVPYHMSGGSVDNHTCHGDDDGTMLLPLYRDTSIEEQPVQLDDLAIQYASESRSFIQKNSDKDIPFFLYVPFSHVHQLCAPKDMPEQRNCQWAAKENATFSDAVEEMDWIAGEILKALDDFGVTNNTLVLFTSDNGPWVAEQSCSGSKGPFAAEWFRDHSSPSCTACPHDYVPQPTNGQPRRCVLPDTELALEGVPCGEDSGLGSVWEANLRMPALARFPGKIPQGSVSQDLISTLDVIPSFLSLLEKPIPLNLDGKDMSGIFTGESTNIEAKRVLFFWRDGFESGPLPPPYGRFDVAAVKYGSLKAWIWTKSAHYNDDIEQYHDPPLLFDVLADPAESNPLDPSDYLQEIQYIKIMVEKHKQSVDMAFPLCLDADPKYLPCVNRETGCRTGGTLPLETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP28</accession>
    <name>A0AAD2JP28_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS23212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002380">
        <property type="protein sequence ID" value="CAJ1968383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP28"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF30">
        <property type="entry name" value="OS06G0587000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1968383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="42627" checksum="23F9CE092E7531E2" modified="2024-05-29" version="1">MSSPAYNDDGDAEAPSASPRGTGGDDDNHTVTKEESSKKGAVLIILAVFAFLLGGGIVAGVWWIMESQKDDSPTPATVANNDPASTPSAPTASPVPNPTLQFTSKPTSRPGSPTARPTPTESPTRFQPVSMEDRLANEHDPLVQNAFEWLTAVDNYQPADYAEFEERYALASLFFQTGGNRLWRFNTGWLTSATACGWYGVTCDSAGKVAGIEMNDNSLVGTMPSELGILSAMTSITILGSFELTGSFPTQFSRLTNLKRITMRSNYLSGTIPTQISSLRQLTTLDFEDNILSGSLPTQISLLTNLQQLSAGGNELKGSFPPGLVNLTNLRTLELDRNQIGGTVPDLSGLRFLEKLDLKTNKFTGIVPNLPNSLQLCDLDWNSWSNTENGLSNGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP59</accession>
    <name>A0AAD2JP59_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002410">
        <property type="protein sequence ID" value="CAJ1968828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP59"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="99" mass="11735" checksum="C2BD4B7263605767" modified="2024-05-29" version="1" fragment="single">DAVKSGDVNAHDRILKEKLLPNDISCRFCPDDDNYKYPLDDDWTHWHRDLKDVGESSPVEADEERKMKEVKLPNGISCRFCPDDDNYKYPLDDDWTHWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPU0</accession>
    <name>A0AAD2JPU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS24496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002524">
        <property type="protein sequence ID" value="CAJ1970480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPU0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="83"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1970480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="422" mass="46834" checksum="00D77CE34631F565" modified="2024-05-29" version="1">MGCSSSKDHPTIIGKSHRAVSHDLRKAHSTYSATMKGGSLDEGLPPQVDGKGHLIPEEVRKRIIASEHVETTIVGTEKQTEIQYAYLTQRGYYPNNIGQPNQDDYSITLKLGGEANDAMFAVYDGHGANGHECASFCQKDIPRSIAKYIRQKRSSRHIAKLKAENKSTKGAFRPELWSTLEAEEYGESCRKAFEETNKALHDTEKINDYLSGTTVVTASFHRGRMTVCNLGDSRALLGTYVNESGSAAIQAIPLSKDQTPNRQDERERVQAAGAEIKSIDQLQGRAEAHDDWGHLEGGDDENPHKDPPRIWVKGKDFPGTAFTRSIGDAVAENIGVIAQPEIESRELTENDKFLVIATDGLFEFLKNDQVMEIVEKSNDPVDACEKLRKASYEQWLQHEDRVDDITIIVCFLSKATTTTDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPY2</accession>
    <name>A0AAD2JPY2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002405">
        <property type="protein sequence ID" value="CAJ1968795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPY2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="140" mass="15640" checksum="B50F6829F80617AE" modified="2024-05-29" version="1">MAMDNAKGDLVILPVSELHVRDKKLWLTSKEKVEELTYKKLKPYVDWSWNNGARFGSSAKNPCPKTLRTRICVAHNSSLDNMSRLLGQCFEITGTHAGVFCSPLQEVSDPVQIGWLLNYPMGIGRAALQKVNSYAISTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUI3</accession>
    <name>A0AAD2PUI3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS12649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUI3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1950574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="939" mass="104903" checksum="B9BB968DD0B81348" modified="2024-05-29" version="1">MVTQRIKEAAEKSWDWYSSRTPKQGSASNPSQPLENTSNQSKPFEILKFPELGQGTADQDQSATSKYWNLAQNAAENTYSAVSGYVSSMSLYSNSGSEDRIIYDNGNFPLTPSNNKVHPSLLTSPAFLNMFQNPYTRVRGLRGADKPSSMDAVRTLLSVTAPDVSEGGYYLSSPRSESDPEDEEDYNVNSPTIGRPIFETPTMANTTKWMESSSSMGVGFFFGSPQVRKHTDGTDFSNAGNAASARQASQIGNTPSETASQLAEGTLRAFRDIALDEAVELHSALRYWSYRWERPFLSWLEAGPTVWFAEEGYQHQLVGQKVSQIQAVLARRCVTIGDLQQHLLRSGWQQGVAKWGVLGDGGDFAAVTGFDGRMPAPENDSDETNNQTSRFGARTPRIKSSISRVSSELSELPLPPPPSASDMPRQTPASKAGKLPHQRRPSSIYYTDVSVRNTFNGQIVTDNPALAEWSVDAMSLVRHQLYRACNGRVTLPFVENWAQGDDQSLSYASVHNFVDDSTAVTNESIGDKKLPLWATVTPQSVAPGGSNAPVTDADDTAPNEEAVKYRVTISDLPLMVQEVAELLDVMEGVMQIQRNRRLDKLKEDSKIRRSWYVVALAIPSIAYVMFKTRDEQYGMGYLKYAAEKLVEFCQEHVVSPLWAIYNELTSGRAENISDHKARDIVIENLQKMIRAWLDEAYPKMPEAERAAKALAMDVALIENQKEASMRTIYELNSVIRLSFIEAQFIKKEMMNALLALDDMRASTNFNLNMAAVTPFVLLMYLTKRAFQFVFYATLRLGKTREETYGNFLHILTEIERLLNIRDAPPQLLYEAGGYAPNANRVDRDPKLLPDHLGGDRVLSTDDLGMLMLHIHTLKTILWRDQRRFSASVIRSVAEDLSELAGERGAVSVRQQLQIIARMHRTYPFLKVAGWDMIGFDGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUR3</accession>
    <name>A0AAD2PUR3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS13331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUR3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30506">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30506:SF3">
        <property type="entry name" value="UPF0126 INNER MEMBRANE PROTEIN YADS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine transporter" evidence="7">
        <location>
            <begin position="62"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine transporter" evidence="7">
        <location>
            <begin position="157"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1951972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="280" mass="30602" checksum="36EC0A723C8B71A1" modified="2024-05-29" version="1">MTMTSTKIAHDDLRKSKSLRLLSSTTSIPRGGSGSGTYSSLISSAQDSLLIQTGVVHQLLEIIDVLGTFVFAFAGAYKAGKKGMDLLGMMILASITAIGGGTVRDLLMGTGGKAIFWLRNPIYIQISFVTTIATYLLWPIFEREFGIKDSARTICTADAFAMAAFCVLGTKRGVEKNLAPPMWVVSGVITSVFGGIIRDILCGEPPRVMYPYKSMLSAGPILGSVIYTLLTSSKQKFDEDLVSVTAFLVTFSVRTWSFDHPWRLPHWPDETIKGRKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVD1</accession>
    <name>A0AAD2PVD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042037793" description="Dirigent protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21650" checksum="DAE9841A13019493" modified="2024-05-29" version="1">MTQLNNLVKLLLLCAMVAVGVNAQIRGSHPFEFIKRRMESKKDEAISRGELQERFGLLPKKAQGSGKRRSLQESGSLRFTGIYNEIGSATEGATPTTVGAVFGLNGFMYDIDSGDAIGSLEGTCTVSASNDEHFCSYHLLFGDGDNAGLVVASGTLTFGDNDGGFLIVEATAFNLDGYQGGIFTLRYDSIENLIFTGEIDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW22</accession>
    <name>A0AAD2PW22_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17460</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17464</name>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17465</name>
        <name evidence="6" type="ORF">CYCCA115_LOCUS17466</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042440868" evidence="2">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1959014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1959016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="278" mass="24859" checksum="2AB81BB1B016FDE1" modified="2024-05-29" version="1">MMFSSRNLALVLLLALISIVVAQNNEQARNVVGGNIRKRALGRVLFDRPMDDDDELSSSKGSGKGGSGKGGSSGKGGSSGKGGSGKGGSSGKGGSSDMSSGKGGSGKGGSSGKGGSSGMSSGKGGSGKGGSSGKGGSGSGMSSGKGGSGSGGSSGKGGSGSGMSSGKGGSSSGKGGSGSGMSSGKGGSSSGKGGSGSGSGSGSGSGSSKGKGGSGSGSGSSSSSSKGNGKGKGGSSKSGSGSSKGKGGKGGKGAKKSHSSSSDTKMDHRLSAGSASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWE5</accession>
    <name>A0AAD2PWE5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002054">
        <property type="protein sequence ID" value="CAJ1960219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWE5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="134" mass="13661" checksum="F11EE8AB00BE7507" modified="2024-05-29" version="1">MCFIGRDSCYGVDCLTVPSKCEGECQEELDDSPACYRSIVLISRLRFICHTAGSKVAPFGCFIAWCRYIVSGSVDAFIARISSGSTGFGNIASIAKSSKGVTLGDGGAATGAGAGAGWPSPVGACSCSSVPGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXL8</accession>
    <name>A0AAD2PXL8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXL8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="511"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="791" mass="88905" checksum="413EFD8D5A3AF45E" modified="2024-05-29" version="1">METSTEMDVNEETAPTASEANDSMDWMLTNYDAAASKPQSLEEELARLQILRSYLILDSEREFPFERLTALASRTFGTPIALVSLIDLGRQWFMSNRGLGDLRQTPRNLGFCTHAILSKNDLFIIPDASVDPRFMDNPFVAGEANIRFYAGAPLIAPEGYKLGTFCIIDTKTRPEGLDFESKQNLREMSAMAVDILVARRQKRERETEKNSQLIACSAHDLLTPLSGIELSLSLMKDDEALMEKLSEENKKGILQASKCSDILQQICRNVQTTFTETKSAFESAFSMSMPETVNIDDLVQKLYAILEPMPKKVPVEISVDSDVPKEILSDGSKIFRCAMNYLVVAATRTQTGMVKMTISVEKHDERKRASLVVKCEDTGPSIELDAYERLFKPVSSNLESYNDGDDEQVSLELALFSVACQMDVIGGEFGFRARQLGDSESNGLGSMFWFSTPFSLPLTKEEEAILLPRKMQKTKLTHADASRFHNAISSMLGGSSESAITKNQVVERQKRALVIEDSEMVRKMLVKALTKMGYDVIEAENGMAGLEELQNTLFDITLCDFLMPIMDGLDCIQQYRVWEKVDRPWFTQRIVGISAHATELDVERGRGIGMDDFLPKPITTQHLTDLLATDDQIAACKRLDTIATKALEEVQEQPIRKRRKTSMEPEFGVQRTCLILASSSTAMHTEMTEKAVQECNWQSTKAHSDDDAWTLLKMRTWNVVLVDDSFAGLIEEFRQWESKKRVTRQGNIVLMSENLDQTTSSKSFIAPDGIDRIIGKPVNREALQRMLDVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAX1</accession>
    <name>A0AAD2CAX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1912854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1912854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="223" mass="24258" checksum="EF83BDAEDC6C657F" modified="2024-05-29" version="1">MICCLESPCNDAESSYYAQVATDEIKMVDKDSHKEQRLLYPGMRRTPHGPPPDHPILNEMIGNNNRLNHNILNNGALNYNTNNDTNELMSVTVPPGVLPGQEIHVRRPDGANGLVEVVVPPGMKEGSVFYVKAPPAMVEEPSSSSNHQQQQSQPQSQQQQQQQQQYQPPVTTTSDANAASNAMMVPQSTATGAPTSLSNQGDFANCLDNSNTEDESSSANNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBU2</accession>
    <name>A0AAD2CBU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1898201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBU2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042280532" description="Subtilisin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1898201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55453" checksum="995F3B5F4EE2CDD3" modified="2024-05-29" version="1">MKTTSVVALYLSSTVITTVNATKNVDRAFRMEFLQNMEEATRQKNQFSYINARKLFTAATPMSAPEFMKPRILDQVEEEARDDAVEDDGATNDIDGDDATGDDAAGDDGDQEANQIVYSINLENYALKYIGCSNIHTYSSELAEDNAGSVLEMNRFITLRLCPKDECSNYYKLGCSSGYGDYLITMGDYLEIMSETYFKQYVEYCQTCEACLYPDSKHNKTDSNNGYYGWNEYATDGNSGGNCRYSGVCSKYRAACKDYSEQTYHLEEYFECSPVSMGDSYVYLGPHCGSDGKSLGIGVYSDEYCNEYTKDLTEISSYFGMDIDDGYMKPFHSNNCISCVASEGYVLDANQAGDGINDVCYDIYGAAAKCNKYMGLDEDANSEVQEANEESVCTFIHNVMTNSYDEFGEIYLGRGGIGSYIRAAATVDGSQRHVLVFSMLLVSGLGAYAAYLHRMVCRSKYPWLPRRGYSTDPKSDPAMLGRDHSGILSGRSFEKGAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCD4</accession>
    <name>A0AAD2CCD4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PSI-J</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1908999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCD4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042129305" description="PSI-J" evidence="2">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1908999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="14925" checksum="5696A4769EB3E108" modified="2024-05-29" version="1">MWKVTLIASLCLFAQAFAFSPLHQTRSDGIQFPSAQLETPENHPLTSARFPNALIPSLAGLSTGLVGFVTKVLAEEDYELAELPPPYIPALFGVVLIAGVGVLTASLGDVMTEEASLGMQSGAQAKKEIERSRSSYFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCR3</accession>
    <name>A0AAD2CCR3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCR3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042152497" evidence="2">
        <location>
            <begin position="29"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1926681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="524" mass="56967" checksum="E966CF2043C4813C" modified="2024-05-29" version="1">MSSSISYIPLLLLLLSIMVSTTKTVVSAIPLNLPEADEVVKCPMVKEIDFTTEIEIADPNVAREWNEVSGLAVSPTQIAPSGAPIMWGHNDGRDQAEFGTNFAAWDPVTGERLVTFILPYDETSDPPLVNQDWEDMTIGSCGNTAEEMGETCIYLADLGDNYASDVINTSIRPADRPYRIYKIKEPVLAAYARTSARSISYPATTVTALEIDYLDASSPARTGNSEGVFLDHAGWGRGGAIGDIYIVTKSRDFGRLYKVPASAWPTNGQTYAKYSPQVVGSNYNDGEFRRFLWTSASMSWDGTKIIMGTVHRNYVFLRCPGQTVEEAIVGRDACMIWENPPEAADDKKQFEAVAWYPNGNTVLNIAESLTMVPRIVKVNFDYSFPPSFCPAVGFDSSGTQGTVCQTFPTSYDGENFVSQVVPDSWCVDAMKFYGSPAPSITASESPSATPSAAPTASGMPTNVPTTPEPTINFFFGDLDLDDNNDRINGDEDSGAASALQSSFTFGMMMMVATMMTMTMLPALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCU8</accession>
    <name>A0AAD2CCU8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS1805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000102">
        <property type="protein sequence ID" value="CAJ1929959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCU8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1929959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="463" mass="52550" checksum="93E5D80160E5521A" modified="2024-05-29" version="1">MVSSQEALELIPKISGGLSFVFSLSTAVYIIFFSEDAKKGFYNRLVIGMCFADMLSSFAHFLSTWPMPADSGAAFAVGNEATCRIQGFFTQYSISSHLYVASMGAFYLLAIKYGWKEKHFAKWGHLFHLIPIGFGLASSITVTVMDIIGPAILWCWIAPQEDRPDLDVNLYRMVLFYVPLWSAMLFVGINLIFVFLYVHRVTKVAEGHVTKWMPSKSVRNISQDAKGNDEDEMYCGQEISTDSSSADVDSEGLGPLDDSASIGSSEDAADHDGRVSRIVRKKQKQQIKMYARRRQEIANQCLRYAMAFYITWTPLSCVRILQLIGRPVPYGLLFLAAAMSPLQGLPNLLAFLYPMMRKKWKLRKHSQKNENPRNEQRPRNEQHDPKDAVKEMKPPSIVAGQPKRKKKTSSDRGIHGSSAWDINMGRQDTYDLDAQNFELSSEFKTEENDDIYTNPELYFMRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFA8</accession>
    <name>A0AAD2CFA8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000213">
        <property type="protein sequence ID" value="CAJ1932213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="40957" checksum="88EB8700EEED70A9" modified="2024-05-29" version="1">MVLLPFDAHNHVHLGSSSSPSSILDLLNDSLSGMAIMSTHPRDFPIVTDLRNNHNNNNNNNQQALLLDQGSIIPCMGVHPWFLHELTERDWEIISSPSDADAIADANNENDDDKEHDDSSQNKGAPMPRWVCELESLLQADPSIAVGEIGLDNFHFNDPVTKELSTDMETQMLAMELQIGLAIQYQRPVSLHCVRAMGSMLEVWNKILLAKTDSKQQKQQQQHKLPPRIYFHAFGGKAATVIQLVRLLEPKQPKRPKKKKPRDEGENKTLVATKEEKPQSSTTITGPKVYFGFAPIVNFQSPKTLDVIRAVGLERLVLETDHEEAYKVPATMKEGIRVISDAFGITEEELIQITNKNAKELYMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFK4</accession>
    <name>A0AAD2CFK4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000125">
        <property type="protein sequence ID" value="CAJ1931131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="28405" checksum="9781524A57EC1A1D" modified="2024-05-29" version="1">MDSILQNGEMDDAHKLVALDLLTAVNSSLYAVNPDLMVSSVLKIMRWSLKYGTSEHTCRSLGVFALVDFALGTVKTAQKPCKLAIELAKKQNLMETQHAPISAAYGFVLPWIEPMSGRAKELYLGYQIGCETGDLEFGMMNIALYGFFCFSIGKPLSNLEADFADYSKQMQDCNMELQRNFLCLTWQIVLNLLGRSDDSISMDGEAMSEDAMLATAKEANNPPLRAQLYCHKLQLCVYFGNFELGATMLSETGKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG77</accession>
    <name>A0AAD2CG77_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1521</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18018</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000058">
        <property type="protein sequence ID" value="CAJ1928658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002007">
        <property type="protein sequence ID" value="CAJ1959597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24252" checksum="BFA818050E1BBAB0" modified="2024-05-29" version="1">MKCYNIEQVNKIFTGTTRKTFRKWTDIFMEALADLHENVIRFEYRLINDNGAPAKVTVDGTDFRSPEYSPFNPGRLSHKFDGPGFRYEVVIAVATGLICSINGPFICGEWPDIKIARNHLHEILPQGEYYLADAGYRCQHSPSITKFDIPDHERETMDELMAYHENINGKFKDWRIMSDRFRNSEEKHGGAFFAVAVLTQLEIAEGMHVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGK9</accession>
    <name>A0AAD2CGK9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS3623</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGK9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="93"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="503"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="535"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="308"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="480"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="595"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1934172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="779" mass="87599" checksum="C4EE0C310F16CA04" modified="2024-05-29" version="1">MASDWPELQSSLQVASKSWASFNWDSKTKQWEAITVQSKEAREQSLSARKQLAETTKQFKKSVKNVEQVGSTLGVANTAENAATTVKAIEVLAKNCRQTVKAYQEEVDNLTRRCKSAESSFSSLTQSLGENPDPYKVLTSVLNLVNNQQMQLSKMSHTIEDLKTEKVALERGSSKNDTSNQESSSTTKAEKEELIQLRREVAEYEVEFRSLKNQDITIRKLEARILELQTGGEEEFQLKLETAREELAETEGRRTAEALEREAAMERKVQTLELQLKAEMAGRAATQAHMLEESEGVGEREAAWEAQRRILVDDAERLRLNLHEATRERDDLRLKVGALEGGKSIQSVPSSGGIQMADLLSEREAYEAEVSELSHTVNLLREEIAVKDETFSDERRSLQSKISLIESEVQSTKTTLSSLQAQLAEAPSQTLIDSMKRELRILKHLEYNADDPDLVNRDPEMTGTGETHEKDLESVLVAKLRRVESELVKERNQKADISKDYEQLRGEIQALEHAKGDAEKVIASLEADLDKAISNSSVAQSTPTARRKSLPDVESNNTTTLQSVLDPNAPSTGVQKETKLEASAAEKAADDHSVATIIMAQRDRLRARCDALEAERDSFKRELQAQVDSAESLKTDNTKLYEKMRYLQSYKGNSGSIGAYARTTSRDLDLEALEQRYEASVDPFRQFSRAERQRKLNEMSPMERTVFVVAKTMLGSKEMRTFLFFYVFAMHFLVFLTTYHWSHSEGGTGCSIQDIEHLAHLPPMTLKTPDEVIKDMSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGL5</accession>
    <name>A0AAD2CGL5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="JmjC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="162"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="582" mass="65269" checksum="CA085AF73C0936A3" modified="2024-05-29" version="1">MSQPGKKRQTTSHIKGNEKKARHEVPSDDSPVVVVKNKVEDAKSISLSPDLNELLHPMTEQEFLDQHFRQKAVHITCDQVGTDNYALKRVSDLREAMFDLDPEMIIRETSSDNVFLWLVDKGGNKEIQDRKSSTIRSIEISDVDTAISLHKIAKHATYCRAPPMVEQNLVASLLKATGLGCGQYDPSGESIISMGRGEVETFISTENHLTNWHYDFQENFTIQLSGTKRWTLQQGTIKDPIRGCTPHYASPEAVESQLKAAHLFDRKFRFGFPEKDVTAVGNVHSIDVKPGDVFYFPAGMWHKVDTIEPGVSINVSLMASNYASIASQALHQLMFQDERWRQPVLNNKRVEAVDHLKALLKELPSMIQRLEQSGGAEAILPPVLRHPPSFLPTGDEGGEWEDFENEEKDCGPDGGKETAGDDGSETAKSVGDREEDNLLDPTKFDSFPENWSYNLELGETVQISRNPLAALHKLTETTSFYDNNDDDDDNDDGKDIFILNVNYAGNETHQSAIRVVFRDNDDSFVQSLYCNERQNGDVTKTIKVSEKNESHLKFLVFHGYLQILDSSSRSDMPGKANATKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH51</accession>
    <name>A0AAD2CH51_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH51"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="676"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="796" mass="87598" checksum="80545BDC96A787D7" modified="2024-05-29" version="1">MFHKEDTALFGVVASNPNNKFIKGGVGGGGGKNKNNANPSANHSAAAHYNNNNASKKKSATMDVPLKKSVRKQLYQRACDYFRPNLPDVEELLKQVFLQGNLSSRSLPLAEKHRSMVVYVKTPSNGDNDNNGNDSIDSNASNVHKYPYKKSTQFVWMAMVDGKTKVVDESPTVALWAILSNCLGLLRFTTNGNHNHKSDDLQSSYNNSDHWHQWYVVQVPAAVSKFVCRGADLMKAGMRSIPNATRPASSENSNHKDGYSSQTVAIMVQGNPQPFAVGRLLLSKQDNNDDDKNNDAEFGYQTKGVGVEIWSTYGDDFWRQSAAPSNLHKGGMVNVLGGGDSFENGHFGNIGFSEGKFVYPLTNMDGQEEDDSDDEQEGNAESERANKAENQINAEDNKVTEVSAQEGENNATDKTAEGNGQVETNDEDDNEDEDTPESHLHQAVCQALVNLSNKDFPMLITTFYSKHVVPNSSQKIDLKQTKYKKFGAYIKEQVALGLLLVGPDKANKKNKDPMAMILGYYKKHDDVQGLTKSAPVLDADAPTKLVLVNLYVIQNSIVSLMRLDADEVAATNATSEERRGTGMLTTPEVKQIVEGYIEREELVHPVRKDQITLDGPLTDAIFPPKQQKQNPQPLPTIMKRKEVYQQFTARLQPAYALVTMPGSKITTLKKGTPPKVEIEVSMRQSRKFVTRIRGMEEYGIDGQVLSKDVSKRLACSSTVDTEAAAGRAALKKGRVEVEFQGNIADELEALLTGDESLSSHGGVKDSDYAIPLKVLEVILRKGVPPRKRKGGGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHF3</accession>
    <name>A0AAD2CHF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000258">
        <property type="protein sequence ID" value="CAJ1933278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="697" mass="78086" checksum="2585F982738894B3" modified="2024-05-29" version="1">MSSIPEGGRMALSPSPPSESSTALSESSTNENNNQFTSITVEFIYSGESSSSSSSTKNGARKRITKAPAAVQKLLIRPTAASLPNRLCEKCHDLHEVVMIEQEEDHEAIIVNSSITILQTNTIKPACQLKTIGDYAFAECIKLPRISIAWSVETIGKNSFARCNQLVQVDLNAAVSKLKHIGFCSFYQCTALARIYIPSTVEEIEGHAFHGCRSLKEVKLLAAFEQPKDEELRLGSLVVGPSAFLDCSSFEKIKIPSSLEKLPKSCFHSCSNLKQVSLPEGLKKIKASSFLNCISLNYVKIPSTVETIEQDSFKGCSALEGVDFGSPHHQQQQQQSSLLKHMEWEAFMDCIALRKMWNYRKDRVQEIQHSAFGNCLALQAVILPQSVELVGIRAFASCPRLVTVEIPPTGMSPQFRIRKDAFVHCKAMINVSLPRSLSEEYKIHGLDNRFGSGFGENGFQGCTWLEQQYGRDLAPFFMGEVSRFGDDYPIHKLCYHSSATSVQTLRKAIQNHQVAKKDDRNDIVDDFGMSPFHILLTAGKRRVDLLEVLLETYPSYILGWEDVTGKKAIEYCFLGWNWTIESMYMVQLCLQNYVTRRLSMWGGSTVWDTDLTAEINSILSEDNNERQQLLWRATFATFQVFEQVEGVSVLELALWKREIFEQSNGDLAQDAAEREVHRARCGSSFVIPNVVSFLELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHJ2</accession>
    <name>A0AAD2CHJ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS3785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3280:FF:000001">
        <property type="entry name" value="Peptide chain release factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000542">
        <property type="entry name" value="Peptide chain release factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="entry name" value="Peptide chain release factor 3, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001964">
        <property type="entry name" value="PRK00741.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556:SF2">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041929583" description="Tr-type G domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="52"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1934445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="583" mass="65218" checksum="C8FE7794027892D3" modified="2024-05-29" version="1">MIFIHFTACIILVATCNGLITHSKLLGRSVKPLLFAETVESVSNKAPEAEINRRRNLAIISHPDAGKTTVTEKLLLYGGALQQAGAVRQKAEQRGTQSDFMSIEQERGISISSTVMNFDYNGKRDFSEDTYRALAAADNSVMLIDSAKGLEPQTRKLFEVTRMRKLPLFTFCNKMDRPALSPYEIMDQIEAEFNLESFPVLWPIGDGDRFKGVLDRMENVVHLFIKSVERGGKADVQQVPMDDLETLEKLIDDKELFDKLLEDRELLDELIPPLDMDRVSAGDLTPLFFGSAMTNFGVQLFLDKFLEMGVKPATRVAVNKDASSDDVLTVSPEHEEFTGFVFKTQANMDPKHRDRLAYVRVVSGVYEKGMKVGHSRSKPNKKYNLAQAQALFGSDRSSVDVAYPGDVIGINNPGCFAIGDTLYTGSNRVAFPGIPSFSPEKFSYIRSPNPSDYKSFRKGMDQLLDEGAVQALRQRNDDGGGPLMLAAVGQLQFEVVQARLKEEYNVESIMEPLTYSLARWVNSGWDAVDKADAAGKLFGIMIVQDRWKRPVLLFRNDWKAASLADEEKYLELAPWSQPPDFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHM1</accession>
    <name>A0AAD2CHM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS4222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000407">
        <property type="protein sequence ID" value="CAJ1934886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1934886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="303" mass="32887" checksum="E873482CE0BF8AE6" modified="2024-05-29" version="1">MVVPNIRNPNRHRTLQVATPTKSQYDLEPENTFACRHVGRRTKGGIGGGTAGGFIILHSSEAYRSNGCNGTGNGSAVAIVLALVGVCLAFIGIAFECSKSEKKRNENRGDIGTTRNSIYRQRSQRAVANNSTAPSNDNATSANADQIHTTSNIINSPSGGDPTPYVTGLIIPERNIAMKSNFYFQTVLLDKSNIDPSALREEAEIAGDSVIENGVPPGKRGINKVANNSSQVSSRFLMSAWRRSTLNDECSICLQSYEPGQTICLAKNTLCNHVFHQDCIEEWFNKDHSDCPLCQVNLVCKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIW5</accession>
    <name>A0AAD2CIW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041911976" description="Fungal lipase-type domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="476"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1934407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="752" mass="82480" checksum="81B996CF547DD82A" modified="2024-05-29" version="1">MKLLLSLILAFELSVTLCFQPLSFRNALDRSKYRDNTRSWLFPMNFEGPDGSTKSRVTTEDVERKGAEQEQKDSDISAFFQSLGQWPLYPSSAETSAEGKKTALEKKAQQQKGNTYPRRLSGDSNPLSNLVKLEVILDLADGVKLNETEQYFSSVISVADQLFKASKATAGIEGSLNISSSNAIRVGDLLQRDKWADPIQSLTSLFESSTVDEVLAKTPTIEGGSILSDTRSARIGLTAEAMLRVATSRLEMILNEASKGLAPNVANDLVLRAVKVFANGTTSVEQLANEIVSVARKTAKTQGLDVEYATDRAKDATKGVSKIVNVANRVFASGYAYGCSTGVAGKPYNTANLETGDLPLFADFDTAGRIEQFQYESVVATGGVMGILSGAIYEDTIKRVLKVGHSLVANGTTADVAWIVTDSIQPSSMFKDPLAATSGEASDDVVFVRSITLRGFDASDDSVDRERLLNNILRAKGTQIDDAVPEVLFHSGLLGLASEIYHEVKKYIDWASPNHKIVLNGHSIGGSLSVLLLFLITMDKGVDFAKDRILRVFSFGSPPIARLSNPHAQGNDNACPILASFDLPTDIVYGYVQPYDPIVRLFTPHDPLYPLVDDLGPDEITLYSSGPVRSLRPIARALFTAWEGWPEFRESWKGANQQYHSVGVQHILMPEPLRYLNDRFFATNMGVPDVDAIVQISSKELLPALIKIFPLDVFQISLVPQATRSFLHHFYPAYDSTMENYATKVEKEMEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIZ3</accession>
    <name>A0AAD2CIZ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000236">
        <property type="protein sequence ID" value="CAJ1933023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIZ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39765" checksum="39442C01A2D55472" modified="2024-05-29" version="1">MTNKFGEEHEFLGMKITYKDGKVEISMKKHIQKAIDMFMDDINREATSPAKAYLFDVREAAKDLNKERADNFHSVTASLLYVSRRCRLDIQTAIGYLCTRVGCPDEDDWVKLKRVLQYLKGSIDLTRVIGGDNIRRMQAWVDVSYGIHDDCKSHTGGCISFGWGVISTMCKKQGLNVKSSTEGEVVGVSDFLPNMIWVRMFLEQQGFELEKNTMYQDNQSAMKILLNGKKSAGKRSKHIDNRFYFIKDRLLSEGIDVVYCPTAKMLADFFTKPLQGSLFRKFRDVVLGYKHIDSLLEDDEEESVKERVGSRTDDSPESDSDESKPSYINRESMENQSWADVVRKMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKI7</accession>
    <name>A0AAD2CKI7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS5533</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000613">
        <property type="protein sequence ID" value="CAJ1937153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKI7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="119"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1937153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="414" mass="46603" checksum="1B66109F820680AB" modified="2024-05-29" version="1">MAIAQASTSMVRPPPPPRPPAGLSRKPPPPPPRRPPAATTAPPPSRPPPPPSNNSRKSGIPKPPQRPPPPPPRPTQQQSQKRKEAPQPPANLSGNKRPRNDNNKVSIRAPVVMRDVDVFEKKGKVGEGTYGSVFVGKDRKSGDIVALKRINTEQEENGFPITALREVKILKALDHDNIVNLKEIVTSKEQGALPKDVYMVFEYLEYDLTGVLETPEIRLNQDHVKSWSQQLLNGCHYMHTNKVIHRDLKASNLLINRKGELKIADWGLARSWNSEMKRLTNKKCSSWPTLEKECRLWKNFAPGASERKPNKLAEALRAKLPHPKWMTDEAVKLVSNLMALNPHNRWSALQALDADYFFENPIVKQAKDLPMRFTVSTVHEMDCRKKFEQKMADHKMRMQALAANGRGPAPPPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKN0</accession>
    <name>A0AAD2CKN0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="98" mass="11000" checksum="04E420A3F01668CE" modified="2024-05-29" version="1">MNPPSKYNYHQANCSSRRRSATRNRQDQHGDTPSPSAMMNRDFPGTAPLVLRSSPFRPLSECTPQERMIRLKAVTQAALAIVNLPLRYDEDTPNGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLI7</accession>
    <name>A0AAD2CLI7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000726">
        <property type="protein sequence ID" value="CAJ1938514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLI7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="751" mass="84087" checksum="8C74F2A3EB799B34" modified="2024-05-29" version="1" fragment="single">SDHRTRGQSFWDQLTGLPHQDSLIHDHIINSRRGMRLDKTIHQSFGHPVTDTTKPGYQVTCPEDFEPEDQRMEELEQLFDQWNDPTLTFAQRMRNGETMSPGFALLVRKGEDGQPCHIMFISNPVLTKPDVMEPNTFGAPAPFGEIVNNDIAQKKTIIENWFNAVKASPASFAVPVVDALPFWSCFPTEHDPVDARVLDVALLAPFQEQMDRFLRSHLMQLIYRSGSLPTSTLGFKMRAWVRMHNMRLAESYPTALGITLPPECQAFVNYLFPFEDEDKGWDGRIPKWYKTLDLDSGTEVPDSYLQYTPRPLPSSAQDPDDYVTQRLTVPPVAPPAALQPMDDDLAEFLQATKRHKPNSRRSPVHPPVTPAPEDSFVLTEEGNFEDGHGTNYVPHDDPGGMQPRTDGQVLPAVTPSPSTYRPLDHVAPSHTSFPSSRDQHPDSSCFRNPSRGNPFAGVMNGTNIPLQSPAQGMPHDGIHDSTWNSPFQQGPRVRIDSTPRGPSPFAGHCPTTSPAMGLPTPVHHHQMFPASPGLPMHHMYPHSHMPMSYQPGYDGTMYPMSHYPTHPTFHTNKPNSRSKYTPMRSASINSEMERRCCPPELKAIGYWLVHPLPPTVGVVRTSLGDRAATDVLQFGLPTAIGRRCLEGFDYKNDGQVAVNIVCTALEYRIKHQFGSFSQVGELQRDLRSVMNSDFVKSSYNIATWGVDPDNAPPPGTSKRFSLLAFLPCVLANLSSEYLPRDGLTWQQMKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM77</accession>
    <name>A0AAD2CM77_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000780">
        <property type="protein sequence ID" value="CAJ1939358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="121" mass="13734" checksum="1B2A5330AF056409" modified="2024-05-29" version="1">MWGGAHNVEKFPQYASYHQSPLCKSCDYQKGQQEGDKDSQAVVKSHVFVTEMAKILAAKQQKVPIKDNVVVKNSKHAKRMAAFHRKQEEDAQQTMPMANNVAFVGPTKAEVNEWFLDKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMX4</accession>
    <name>A0AAD2CMX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuf2 DHR10-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS5207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="5">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1936469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="96" mass="11223" checksum="B074ACCC51BACF5D" modified="2024-05-29" version="1">MKTNKASTLIFQDAMELRQHVIEEADRYEEAMGEVQKTMKEVEENNEKIQDLTEKADESELALLRVEEKLAHMRKQSKTKMEAAQDRLEMAKEQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNU6</accession>
    <name>A0AAD2CNU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000921">
        <property type="protein sequence ID" value="CAJ1940621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="568" mass="63009" checksum="BB48B286D05E643A" modified="2024-05-29" version="1" fragment="single">NKTNLRQEQHCLIYKGVSDSLTMGCSSSGGGKERVTPQKVKSNLSSTVVKHLFSMKDENNGKARSSYKDAEERVIDYIQASGMKRSEDMVKSIQDGKLIDFNAIAPTLNAPTQTEAVARETEMAQNKILYSAKLDENMRRSAYFKMNKQTVKSNIMLKFVTKAMDIKLPGEANFTTTLEDPIELLKRIERFMKKSADAEYDFLDFFWEANQKFFAMKQGTTENLMHFKERFLRQAEVLQDLYGVAWFRNFAAKTKAYAAIASTDTIAKDKFKDDIFEAVLATGFLWNCDRTRTAPLMIFRRTTAGNPKTVSKAQDILKIHMDVIKNLGVNLYQGKDQPNKGKGKLKDDKKKAACYVCGKEDHMSPKCPDRLIPESQWKHPKHYVDYGKKLNLNQIGATVPATATVPGTSPATSVNTGGTSSVAGSVNTPLRLAGTTSDQMMQVPSGMQLMQIPTQGGGTVTVPYSINSNGEIVFSGMQLSQQGFCGAQVSQGFDATQARTPQVVKTGYFDTSNVFHDAIMGKDENANDVYLIPCPAGTTNVELQSDWHYASENEDLPDLATEADRGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRK6</accession>
    <name>A0AAD2CRK6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001213">
        <property type="protein sequence ID" value="CAJ1944160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="150" mass="17756" checksum="75A8D1D672496FCF" modified="2024-05-29" version="1">MERMVAEIRLAAKQTASEPVKPKDLTENEAQQMVTDIKAAPESEDSETSKELTEQEVHRMIVEMRQAAEKADSEEAAEREMQRMVDEMKWATEEQVEEEAEERAYLERKRRQRRRKIERSQRRSKSPSRSRSRSKSHSGRKSRNRSHSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSS7</accession>
    <name>A0AAD2CSS7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSS7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="44551" checksum="4749121CD634A35E" modified="2024-05-29" version="1">MLTEPNRSRGSSSDELPITTGNDQGLKKRWVCVVVAIAFVWVNLYSPMLLRTILRAYQSSNSATAKPNTPRLLELSDEERRTLQRVTTKIYFSGMPQNAPNTTGAFIHVGKTGGSTLATVLRNGCHSFLDRPCQKVRNESIVSKTVTYYHTPDCDLLAQQPHDYYIWTVRDPFTRTVSAFLYQHPYNVYIRLKQYNEKVYAFPMRKLYPIFSRCFKTLNSFAKALKHQYQRNTNITLNAAQTLKCEVLASAMFQHKAERLSHHLHYDYRMFSQQLDEGNKQAVLVIRTEFLWHDWTVINELLGQTPGTVFSNETSQLRNTTKYALPVKPIIGDEERDYLCESIAPEYRVYFDLLSNAINLNREDVRKMKEIAKKNCPKLELPQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTR6</accession>
    <name>A0AAD2CTR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Armadillo repeat-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001502">
        <property type="protein sequence ID" value="CAJ1945769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39896" checksum="6EDA33A6BCD5ABB4" modified="2024-05-29" version="1">MTVTIQLLLDIYSGSSSWEENAAATRDFNHQLLKRGKFTLDAIKKRGLLWAVLSGLGHEKEPGASHFIFECTALLGTIADTPKGAKAIFQMPNGLAVQKIASLLSHKEACVQEGAIWCIAKLTSHGNRDIHDSVLQPSLGVIKTLKHLFFQSGNDSMKLKIFSAYALSNLNNGIVSSEYDAAKLPIIDRMMEFFKEVQFQFDEQGRMLEGIIHCIGNLLPGSDAPTQEDIRARLLPHVQEWLQSSNETLRKKACWLAANLVAGSMAQIEWLLSNDGCFQLLLDIASTPNWNVRKEAIRVLCNAFGCGSREQIVNLIERGSLTPLSQAISTTEADYPFKEEISQVMIGAIRVYQKHLVAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTU1</accession>
    <name>A0AAD2CTU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001358">
        <property type="protein sequence ID" value="CAJ1945335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTU1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26990" checksum="0F223E45C76C4C9E" modified="2024-05-29" version="1">MTSKVPWNPGTVQVGKVSIVHEDPRDDPKSNEAELRQLDPIMQGMNEWRMVQQTIVNGERFFQQVGRMDDDARFADVPVRPSFVSTERHTKVTAENLSERLGIGLHRARATLRSTLQRGPRSAILPLARRYRADRMFLRPRLKGKFSTDTAYFNHKSIQGNIASQIYFHKSGFYSCHHLSKVDDKQVGQTLKKFIADYGIPEHLTMDGAAVQVGRSTSFMETINRATINYHISRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU39</accession>
    <name>A0AAD2CU39_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="467" mass="53072" checksum="1F1E78930F40DA3E" modified="2024-05-29" version="1">MRVNSSSIRPGPRCFNLKDIFLVLISSVLTAYVILNVLIFQEHSDNSHEVSRNNQHPSVAPFSLPTATTTAQEASILDGARILVAIVAYDFSQAPHLEEVLDGYFDLCAAGSWVDVVIYSTIAWPVAYIDMLNTRFHCANTSPRAGFTINIHLKSPDTRLHLVDFHRELFYENLEDYSLFIYTEDDIRVSPRTVATYLFETRRVIEKLGPEKASDFNVGIVRYEYNYPSNIIIDDGTRHATQNVTRVYWEHSWQPPIGKSVDIIPQEDILPGYIHMSNHHQGMYLATQDLLRAWKDRSGCEFNVIKNRPSAKGKPYQPAEGTQRVWMSSQQLYGNRHCNVQQLLPMESFGALTVLHLPNKNYRRVGHKGRLGGSKDKQKELEDISAMQAALPVVSSQLLTAMQLHIALRAKWPPKPQLPYKGIVMQDQVEGKQSNDPLLVQRMKDYRAYVERGGVMSNKDMENTVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU92</accession>
    <name>A0AAD2CU92_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU92"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="260" mass="28186" checksum="05FAFEF0C58F9072" modified="2024-05-29" version="1">MQGGNDKEMMEAGSMRPESAIDMVQQPSADNAGKKNGLFRKMQSSYGVALWLIFSLVVGFLGGWFAGGAATAAGEISDGAASSMMNDVTTTTTTTSGSTSNTTTGYNCNCTTPEVVNNNSSITQPEPPSPDDICRALFPWMGRENTTCYIGEWYQCVDAKGTLDIKYFDRLRKSCPSRNDCDDLASCAVSKSEVFFEGPSDGTVPDVYDYCNNDVAHRHYPEGASAATRTHSELVGLAEAYLEGDYSRLDYRCKNNYAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYC9</accession>
    <name>A0AAD2CYC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="930"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1354"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1410" mass="160645" checksum="4ACA7C86EFF2E9F1" modified="2024-05-29" version="1">MSAPPPSNPPTTHRKAVSHGRGWFEGTMGVISGIGAPRPMTPSEGNRPRTNSWSAPNSPARSGVFPSIHRLPSQDSLDRSIHNESGHGKSVAQIIKDLKKANADLTDQMAAMEVKHMNELEAATRPNVEKQKKVEDAFLTLKKQMAQLEASKIAVDSKVKEKDSQLLKAREEASFHRHETSNLKSQLHQLQNELDDSEGRFDDIEQIMAENEDMKMELEELRFKLSAADTGKPDTKVIDEASSSYADVRGSDYFQQWQDTQGELESHRSTLTATKQDLESLQLERDSWHQEQNQRVIELETELHTKSEKWSMREQEMQSQIQSMEFDAVEDMQNQILERDDIIVSLNDQLADLSAALAQAKEQSVDEEQYRRDEAEDLRILHDAQEEEIVKLRKKLEDAQKELAFRDEEINEQQTTLEKTNTDKNEEIERLQKELKHSQEQLHEKSLPPLPPKEEDDSQLILELEDDLDSARAKIASLEDEIELLKVEMGVENIDLLEREIDDLKLTLEEERQKSAVATAQKAVLQEDIARLQQGLSADATLSEEEKKADTEENQKLLQEAKMEITNLKSTIESMKSSESYKGEKHKRQVREAQLALVALDEEKDELIKKHGELLMAVDREKEKLEKDSFKKIAAIEDELIIAQSLAAKCKEVEAEKDALGKRVVHLEEQITRSATRPIGTTLADEQAQSQLESISEENQELKEKLKDRDTTISALVRSSMGVEEKMANLENDLVEARSSRDDDLITADGEIGELRIEVEAMRLNEQRLRNDLKAMERDLNFAEADATRWQLALQVDETSGADQRFQLAALQRNVAELRDKLHERDDTIEALVAESQTAENESKELRSKVISLTKDLENTRVNNTYSDPELRDEIQRLQTENDMFAGQIVEQDEEIQHLVRELRLRDQSVVELERDVQEMAERGGGGQSREEDAREIQALQGQLAEIQSDLRLRNQQLLQYRQELESIQQQGAFGGDPAMAGDISDLQAMNDDFRIELRELRTELWEAKQAAAASEDLKLELAQAKYAFDEYKRKNGSGNGTIIDLRKELESSKKEVEKMKQLKEMQEASKNYRTANESTLSESFERKSKEKDATIAKLRSELESYGTKSGDMSKGPSRMTELRSENKALQEQFKVELHAKNTQIYALEQTLHAQEQVVQNLRREMNQLQNGLQLNIKGRQGDLDEMQEEIIVMESKAKRQEREISGLRVRLEEAQLDHRAEVSQLRDLLRRKEQEAPIARTVMDLKNEDRLLEVHEHLANLKSHNTKLQEQNLKLNGRLERATIEIQSFASQRGHAVELEQDNRHLRNQLTDMERVLRSYSQRSPTVTTIPLSRVSTAPSQVSSPLPSPSPSPVTVQSSASSATSSLKSKKSNKPFGGLFKKKKSKDKTGETKAMPITPENEDDLHSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D1B9</accession>
    <name>A0AAD2D1B9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS10477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D1B9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042221737" description="Fe2OG dioxygenase domain-containing protein" evidence="4">
        <location>
            <begin position="29"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1946336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40717" checksum="C5D601219EA48018" modified="2024-05-29" version="1">MRFSSSSRILFCLAIVIIIDYQNVNVHGFVSSVDPRCRRPTAVVRFVVQDNKSSAQRTTHDNSNQQKQEQLPLGPPNYLSSLPVDKNNGAKLFRYDNFGVKQEFEVFHLSNTPEIFLLRNYISTLERYTIQWNGRNHPKEATVYDSNDATSKTSGRSRSNVSWLPPWAANGIPLTLARCSAQLLLSPELKGCNSRGAMALCEPMQLVHYDSKGEFILHHDAMGRAVTVLSYLNGVGGTWFPLANLDRKYGPIPRNKLDTLQMIEELDLKPGKDGLLLATAGHHDGLEEEYDNDCIVHIHPGDTVAFYNYNGPNNQVTNDESRDLCDVDWSAIHAALPAKEEKFIATLWYQGGPLIRRPESSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FER9</accession>
    <name>A0AAD2FER9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000269">
        <property type="protein sequence ID" value="CAJ1933430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FER9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1933430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="582" mass="63141" checksum="253592C9A1BC17B6" modified="2024-05-29" version="1">MLPLHKAAFYGNLERVVKLLNRGADVNETDDDNDTPLAMAAHHGHVAVVRLLLERGATNSVVGFGLTPLMIAAIEGHRAIVNLLLDNGAEVDEKDYDGRTPLYHACESQELNTARLLIDRGADVNIVEQECGWNLLFCACSHGHLDVVQFLLDPSIGFDNLEGRNFFGSAPLHSVFLGGNTRMQIASLLLDRGVNIDAVNKKGCTPLHFACDSGDLQSVEFLVGRGASLTATREDGVTPFYLACALGYVQVAQHLFNASRDQMLDLQNILEARGIDETTPLHVACQNGHVPVVQFLLNQGSDLEAIDGGLGCTPLIIASGQGESQVVQMLLRHGANIEATTNDNATSLHHASQGGHYEVVTSLLEWIENKGLDRDSTVDAMSERGGTPLYCACKQGHLEVVKILLDAGANAEAAGTDEDGGALLHGASLNGDLEMVKFLFDTLPSDCREAKDRMGFTPLISACMGGEIQVVQFLLNNDADIKATSVDEKTSLHFVSLLDGNYVEMAELLLDYGADMEARDEFGDTPLRIACENDHLQVAKLLVERGATVDDNKWTPFELAEQDDTLDLLFTVIRKNPWLCQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFT7</accession>
    <name>A0AAD2FFT7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1920467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFT7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="323"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1920467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="512" mass="56351" checksum="8369899C382FADBD" modified="2024-05-29" version="1">MDSHSFVGLGYYATSNPAQQSYSTESSNPYQQYYGKQQSPSTPNTYGYDVYGDHLRTGEVNFVPMTDVTANETPSDHATFAIGKESTVPPGLPPLPVGVSEPSGSMPAYLQHSQMLPSFPSPLVDGPPRTISIPQTEVVDTSALQQQQQQIEEGRNKALEILKQFGASKRMEESQIQKVAEIGRSKALAILENQKLQMMSGNDGHLLSLDALPPEEWARRRRVCFEKLQRKYEKAIFRNFEYVARVGEERLKAQAKQLQNTERYHSEMESYHAQVLQDRAKAYATVRNKDYSFTVAGIGTQQRQKAERKRKRTQGQQDSSSSVAIYVSNLPTDGSVSEELMRALFGSYGSLRKIHFYMDKRTGQPKGDALVIYNTSISSGMDDDRGPADVKSSIVEAVCSQMNGAELSCGTCIKVEPSDPFYQLRKKKEAPPNYYGKAGAEDSQTAAPAAPAAPAAPAAPAAVEENAEELENKEESAMGVEEGTSKPETGDDNGKDEDGKDEDDLDDFFASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG72</accession>
    <name>A0AAD2FG72_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4917</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000513">
        <property type="protein sequence ID" value="CAJ1935815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000513">
        <property type="protein sequence ID" value="CAJ1935819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG72"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="225" mass="25401" checksum="5794BD1A14C80CED" modified="2024-05-29" version="1">MLVAEQFRHILEQGARVTPTFTRSEQSHFLWDLPSRTVVAVESPYCKDSNDRCFTTESTFCHTFVFLYKSGYLDTTTGNRLGKAFSGASLLRVLLQSHEFVDFWPLCSVLPLDTPMGQVMHCWSRMFTACLLHYNLDVATAVRYVGNIHTGAHCDWNALEPELRAASVDDGLVANLRCVLVDGCPNYVNATLSEKNRRSFAEYGNHDSVYTNVKKTQKAVQKDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI69</accession>
    <name>A0AAD2FI69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PROP1-like PPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI69"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PROP1-like PPR" evidence="2">
        <location>
            <begin position="116"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="642" mass="73075" checksum="216698BED13E43A7" modified="2024-05-29" version="1">MEASSETSHAFDDEAWTAYKTAVDEMMTSTRVLKNDKPENLEEAKAALLSKNLLPLNTTTTTTTSQLSGTTTTTTIAQQTRDQWTTQAADYKEHYNLTKQQFNFCMRVLVYLGDYCAKRRITAPIQVAWEKLKESGIIPAENAFSTYMYILGTDNACRDSLLEVAKMHDALFAPNEKTVTLRIKTLIAKNEIAQAEEILSSLKNISDDGDVQKLRTFLPILDHYCANGDCKSILRIYRDMRESSRVHFDVDTYTLILCTLAEEGCFSANASPIEDAAKAGFNATCGPMLFDQLVAELAEDLLELTEDSCRSLSTSLSKSICPKDLVDEDQLPLLQNATQPNSSPLVVGRTKIDLETALCPATGAKLRLINLDEEQRQHVHDTLIEMAELQFLEFTKNRKHPVDENGNKGLEELTKFSEWLDNREGEPFTVVVDGPNIGFFGYGSFHYSQVKAIVDELERMGEKPLVTMPNKYIGPSFFLRKGQHQRLADKDLLYIEKLKEEQKLYVVPQLCLDDYYWMLASVSNQTCSRQGQDLRVPVSSNEGRFPGVRPILVTNDQMRDHKLDLLEPREFRRWCSCHIVNYNLLKTNADEWEDRQVKLFPADFFSREIQCNPWGENADRHAWHFPVTEWDGSDRFLVSIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ44</accession>
    <name>A0AAD2FJ44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000435">
        <property type="protein sequence ID" value="CAJ1934984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="573"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1934984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="598" mass="67187" checksum="B6903FDB7032AED4" modified="2024-05-29" version="1">MSNKQAGCFVYRVIDAEYPIVVRSAPSWDDAYKTKIQAKNGNLVSIDCIIQVDHDNNNNKGGPKFLRLADGSGWLFDRAFSSNGNGPVIMEPVPVESGLWCFYVDNNPVGILLRNHPIDDCASTDLNNFVLPGITLPPQQKIYCDRKVIDGSTTFYRIQGSISSWVFDKRGARFMLVPEHSIACGLFAYQITSNDGVAMRDQPDVGEEAKIPNCIADVGNLVVGDYLRQSPHGESNGPFLRLTNGMGWLFGYKYCQQVMREVLIGTGLWYWKVVNRIQLRKQPIDLFQYRFPTEYPPGAILTCDRQIIGANGVKFYRVKGTTGWVFDRRDDYSMLTPCSAPNGNSLVMMSSPPASSLPISWTIDFVRGVACAIEGIQEIGLNEESRIISFSKDGPTKTRINVYYTTRTIGTVLDHPSQGRTQLFRRDCTIGELAEIMRNPRVHTSKGYTRKRQRTSAEQAGSSIDAEEETRNKLIEVDEALETLEERRRNLVASIVEHDSKRHRLEGDASKLLNNHVQTCDNEKRLADNAREMAIRLVANAEREKASRTCQICNRVFGSVQALDNHNGAVHTHQCKFCYKQFSNPHALNQHCTATGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ66</accession>
    <name>A0AAD2FJ66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ66"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="1">
        <location>
            <begin position="190"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="249" mass="26963" checksum="D637D7E601500179" modified="2024-05-29" version="1">MAQRRCLQKISCRFVRPSRQQQRASIGGGNLGARIPNTKVASVRGFATATDVAANSVPAAKTLPEAFRNSTLCCDDRNYTLVRFPTSSMGLALQLWNHALVASTLSNTTTATTTTTTTTAPSKPPPSFGGFLVDKDEITMLVPSDVYTWSIAMNNMNKTTGKQDDSLDAGTDNGIKYRLFTFDDVVLHPSLVGFMAVITRALADHDISVLPYAAYSTDHIFVAEKDATKTRSILEGLPEYLSKDTDGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLH6</accession>
    <name>A0AAD2FLH6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000998">
        <property type="protein sequence ID" value="CAJ1941020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="242" mass="27413" checksum="83701CB4951B770E" modified="2024-05-29" version="1" fragment="single">MVVVINKICENATRDDNESSDSNTQWNYGRSNNGSHGGQFIQRGHTDDDSRPQGIMLFQLNNYRGIHLDSGSTFHLRTSEHDFKEGTLQGIDGGFHYTSNIQERRLYREGINKVFDSVCKLDTRASDNINSLSNMVKDGFDVFMDTKRENSFFVTRNGITWRFGHRNGLYTLVDEPAMVTAMFHDHARGLDNNDVQGYCALQSVEKNKEGFTNKQVKRANVAQSGYHMMGAPGAELFKLAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM54</accession>
    <name>A0AAD2FM54_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001249">
        <property type="protein sequence ID" value="CAJ1944812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM54"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="93" mass="10293" checksum="264D40ED867B3437" modified="2024-05-29" version="1" fragment="single">EDEIVKAYALSGELLGESEGMRTANDKVKESTSGLIDWAFFRGSPAEGMVGTLEWTKASYGTVESYLEQNAGFSVSQQRSFREQLHPMELPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNW5</accession>
    <name>A0AAD2FNW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vitamin K epoxide reductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS11354</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12916">
        <property type="entry name" value="VKOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="entry name" value="VKOR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044698">
        <property type="entry name" value="VKOR/LTO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34573:SF1">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34573">
        <property type="entry name" value="VKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041979778" description="Vitamin K epoxide reductase domain-containing protein" evidence="12">
        <location>
            <begin position="26"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Vitamin K epoxide reductase" evidence="13">
        <location>
            <begin position="115"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1947879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="476" mass="50813" checksum="8A3FB3195FED1CA1" modified="2024-05-29" version="1">MKLIKSRAFTLMMLGCTALFLSAEAFVPERRRRPRQQQQQQMMTYNHHHQRHQRHQLSTSSTSRIHLFQTNGLSAARTKKNVLRTMTALQLQDAPENDDDDDDDNATVASSYCWSPGLRRVMGGIASLGAAETAFLTWNKLASASSGSSSSLPFCGVTNGGGSGGSSCSDVLNGPYAYLPFTGIPLAALGLMAYLTVLGLALFPLINTSNSSFQSSQSSSTSTVLDANADTDADSDATNRVLLMGVTTAMGTFSIFLLTLLFGVLQQDCPYCELSATFSITLSLLAWIGGCLPDASANKEMAQKGAQMTASGFLTSTLFAVSLFVFAADGDPTAASATIGDFGSTSPSNIVATAAASDNGGGKEMANAPPLITTESSNQAIQLAKDLEGLNAKMFGAFWCSHCYDQKQTFGKQAFTKIPYIECSKDGFNSQSKLCKSKQVPGYPTWEINGKLYPGEQSLEELEEVVAEIKKGMTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPE4</accession>
    <name>A0AAD2FPE4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001744">
        <property type="protein sequence ID" value="CAJ1948171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPE4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="167" mass="19648" checksum="89855E3952ADB565" modified="2024-05-29" version="1">MNTYEELAMNTMFGTYAWNASPVDGTDIQRAFAAVARHFKFPLDNAAVALSISEARQKNRTRHQQTPGQNTLEHIETMFPLFWRQKELLKLLNEERREHTEGSRIKPERDGNLKLETLSWCGNKCNQTPLQEYQQNWCYKQKDLIESLRKRQKTRIDYKRSQGQAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ89</accession>
    <name>A0AAD2FQ89_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ89"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="95"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122729" checksum="64A7EFC008F66B6A" modified="2024-05-29" version="1">MQLLDEYSSIYQDSTDSSLSRKPDVSVSTATNSVYSLSLSQHSTGLAVEGSTSVVGNGLKASELRKTKVGMPRKSLSLQTSAETLNQGLGFESMPLVGRGKEVSQLKHCFDRMLQQIPEDSQSSLESKKELVLVKGESGAGKSAVAMTLEKEVLEHADGIFVQGKFDMNTSSKPYSGICKAFGALCQKIMDSPAEAVCTVQAAIHEQVGNDADLLVHLVPELKGLLTDPVNDPAVTNVGADAVQGGLERVRFSLRVLMRIFSSTFSPLVIFLDDLQWADVSSLQVLEFLLSDTQNDNRLMIIGCYRSDEVDENSLLHNKIAALQEMTTKYNFCVTEVSVGAFGLNEIEQVVSTLLPNPNVSARLGLAKICLKRTLGNPFFVLEFLKMLHQEGLVQRHTDASKAFTWNVDKVDNETMATANVTVMLHNQLTKLPQQVQALLQCAAYLGSTFTESTIDLVWTAYGRRLVETKLERTVALLEIIVKEEVLEKYANSKYRWVHDKLQEAALSLTGKQRESFQLDIGRTLYYGLNRKQVEEELFSVVDLINNGNVLQLTEFASANLRAAEKARDLSAYQSAAEYAAHGIALLEDDKWSSDRLLTLKLYTMGAEMEAMLGNVDATNRYTEEVLAQGDFEQLEIVPLKMAKANMLHHDFKFDESVNFCMQILRDLGCKVAWARRLVPVQAIVTLMRLSKRAKALPQSFYDKLVPIKDPRQMAIASVFSKLVTYSFFKGDMLLYTLLNCRLLEMTLNHGINEFSAKSFASIAGTLIIANEDYETATTFNNIALSMIKKFRGMHASETTYLACGPGLAWVIPFEEIQVTLRSAVAEGLREGDSMAAMWNLLTSHVDLPYAMGRPLAVLLKEISAVCIQCENEKVPLNGVAAETMRQMILKLRGASGSNPIELECDMFGLSKEEETNSVNLGFIHFAQTELALFNGNDYESAAKRALKVGDEYSKLIPAYPMFMVELFHRAVPLFAAARLTKKRQYKVEARRLLKRINKWIKAGNANVQYYFLFLTAENLVLDKKYDAADEMYNDALAKVTAKGHLNHLGLINERYADFLIEARSSEARGKEHLNKAIQYYKEWGAESKAKMVEFRLSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQH3</accession>
    <name>A0AAD2FQH3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS12100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQH3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055412">
        <property type="entry name" value="UVB_sens_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24160">
        <property type="entry name" value="UVB_sens_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042188270" evidence="6">
        <location>
            <begin position="22"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="72"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Root UVB sensitive protein C-terminal" evidence="8">
        <location>
            <begin position="325"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1949448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="475" mass="52340" checksum="86D9F102617E71AC" modified="2024-05-29" version="1">MSSFLVRLIIVSLLLIQCTECLSSDNKRRLDIVSTNRNGGHTKVFHLDADGNPRVDPSSSSATAKRRIQGLQHISSVIRSTFLPSGYPTRTPSGYLQYSAWSWIQDLSTQLRSVLATQRVLEGVGVGREGATAISALMNYLVRDGCGMAANLLFTSGWSTCFRTDIKRWRLFADTILDVGITCEVAAVLVPQAFFLPMISIGNICKSICGVAAGACGGAINLHWAKGSDISDINAKFGAQHTCTGALGLVFAALFARSVNQTKPTVLWSLYFLLTFIHIFANTRCMKLISFDYCNNTRLDILLAEFFSKRRDGGDTNESLFQKLPTPTEVSRTESLFFGVGDGHRGLLTSVPFRFGVDFEEFHQASRGNLPMQSDGTVEFDSEKYIITAGMTKRNKKCIAVSFLSDASPRDVTKAYFHAMCLAIQIQKGDTLHSLTDIQDLWNPFEALATKAGWDLDKTELRSEGFELTLHSNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQQ7</accession>
    <name>A0AAD2FQQ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="305" mass="34929" checksum="9FA895BBFBB058B4" modified="2024-05-29" version="1">MRSVPVEETTFCDSMWACLLNDYGDEDQSLRTEVQPRDSRHRERSDGRQRRSSSRSVKGRGRRSSSRSVSKTRSRSKSRAESRDGHRRSSRRRGSSAQSRVSNQSKNRRRESFINDDDEDSESEHELDRIQTEQPVRPPPVEEMETQIPQAPSEANEIRDAREQVNDEPASERMPSAEKPRNMERKRPEKLTIDGGGDDSPRDTNCSRDSAPGRRDEAPPVLFRSIKNRYNPRSPSANSPRPSPRVLSPVSSPRSPSHLRVDSAEFNTIEDYQKKVLASRDKRSGRKFERIQAIRAKSSMTRADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR66</accession>
    <name>A0AAD2FR66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS12442</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR66"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1950140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="26903" checksum="573A814748CA0D42" modified="2024-05-29" version="1">MSESSLRCVLVYRLEKAGKAICLAKYDHTYEASGGAASGRDDAFAEAVQGIISNDPPAGISESNKIGGFKVVQSDEHQVTYGCDKDGVCCAVITGNAYQSRVAIGCLNELYTDFMAKFGKDTKSAAANSLSKKSKAIMKAVSSKYEDPSKVDKTAKVLGQVDAVKGQMQSNIANMLKNTEKAESLNEKSNQLNEQASVFKKRSTDLKKQMRWKNLKMTILLALVCIAIACAIIIPLVNKAKAITGNGSGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRC8</accession>
    <name>A0AAD2FRC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS12536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001762">
        <property type="protein sequence ID" value="CAJ1950332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRC8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1950332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="432" mass="47283" checksum="1C9563DD71829EFD" modified="2024-05-29" version="1">MSSFRRLGRGAKSSTVSARSPQQLIALQGVKPWTGGIHLTSVGLNQLDNVLGGGQPIGTCIFLEDDRWTRDLAHSLLKYWCAEAVSQDQNLVFPVVEDSSPSPFAVSTQTTKGRNIVSDEIFRLLMALPRNLHWVKTQEQQSASPSTIDTPSALSVLEEDDQGENFEEGLEIAWQYKKSVQEKMLAQPFIQQRSQSSSSNAFCHSYDLSARMTDQKALNPADYIVRIRDLGGCCKLSPGILLFRELVSLLKKNEGKAFRMVLYNTNPALMSVALPLFLSHVRKHKVAVVLLVYSQPSKDYKSLSRLSGTCDVVLKTEGFSARRIHPPPPEFRLLQGILTISKISTVTSAAATGGGFFGDISFSKRPAAFVYGFKRDRRKLHISLLHIPPEDYARGGGSVGSGVRSGAGTNPEKKKTQTFGCASNSGGSALDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSE7</accession>
    <name>A0AAD2FSE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sodium/solute symporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS13175</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10322">
        <property type="entry name" value="SLC5sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF3">
        <property type="entry name" value="SODIUM_PROLINE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="497"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="672"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1951662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="78922" checksum="7F8CEA74EA558D7E" modified="2024-05-29" version="1">MPAEDHVTSVIATFSGYSVILVGIGVWAYKREKALKAAHQDEMTAHYLGGRSFGPIMTAATVFASLFNGFSIIGAPSESFYRGFFSLTWIVSVVGIISGYFATGLRLRRASEVRNHQSSVDFITDRFQSQYCRASIMLLQVVPTGIFLAGQIVAIKLAFNPVFGLEPDNQWPSIIIVGVILLFEWAGGLNSVAMTDTIQGFVIFVSYLCVPIAIYMNYGGYEDIDLSTFPRPDFFQTPSKFDQWQFWQFTIINIAFFGLPPLIQRTYAARDIGSLKLAYGVLVCGVWMAIMVGIFVGIMAVKVFGPGFYPPSPFNSMMENLMDLGGFPKVTAVVVVTAFLAAVMSTIDSLIIAASQLAMNEMVMPWVRNNERLSSDRSVTWFGRACSFVITAASLAFGLHWEGTTFSIIELQLSMTLQTVPAWFIGLYSKHEFHPWPIATGAWVGGLWVVLFYEYYMRDNPDRLPINNGVSGLGINLAIVLIGESTRVLLYPNKTGDRALEPEESSNTNTNSLTTDPTTDGSESDEGKKEPRLLFPNRPSWDVPSLAHFGDKPMSWRVLKKYMSGTHEVATNPYWVTFMLISMSLATPLVPQKEPPILEDGTFAYEPTRVFGIPWFAWKSILFSVIPSFFLLIEIVRMPTKFGPEKEDWEIFDDVPQPSFAEKERLIGGDNSIKFNAQSTKEIDDSSGDSRNGADGKSLPMEQAIENKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSM3</accession>
    <name>A0AAD2FSM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS13333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052530">
        <property type="entry name" value="NAD(P)H_nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43821">
        <property type="entry name" value="NAD(P)H NITROREDUCTASE YDJA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43821:SF1">
        <property type="entry name" value="NAD(P)H NITROREDUCTASE YDJA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042099996" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1951976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="312" mass="34317" checksum="BA8E66D763EBC5D0" modified="2024-05-29" version="1">MTTTAIAVLVILLIQPVFGFVVPPPRPSSGGIHHSCSSSHRPTFTTTTTTPGTSSRLFALERAKEVFDKYSISNVISSKDLANMLNSLDVDASREEADALFRYLDTDGDGSITLEEFLPWYSETAEEASEISSTFQSLLLGRRTVHQFDQTPVSDDVLRRAIACAIAAPNRSQSEPWRFIQVGPETVRKFVSLKESMEAPQSESSNNWTKIPGWCVVTSKLSDDPVEELDDFKSTSCAVQNFMLSMWSEGIGTKWTSGPVQKTQEFADLCGVDTKVEKVAGCIWYGFATGGLKNADPKRRKKGVEDVLTTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTG5</accession>
    <name>A0AAD2FTG5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="339" mass="38011" checksum="BEFB096ECE058BAC" modified="2024-05-29" version="1">MKLFRKKSSPKEGSKQRRSSGYFDGRRRRSSASKGEEKHHLLETSAIERESEVSKHSTSPSSMRSHPQGDRYTASVPEIDSIVNCVINVDRMKNEEKCKATKSSESVDSAHESAQRVMTEHATETIKIGPPKVSFASDELETREDPPGDQNYQYGVSHGDSADNTDIILKEVSEQAAPPPRKTAKKSKIINFLLKGSPLHKNTPSKDKKTDSLNTTIETSRSSDSDDPAALSSSSQRLESRDSGDSPKEGRTGESTEKKTPVRTGPVEITNVNLSRLIKHKNAPKKEPETPILKPLKANRSRPRTMSMSKRNEEQFQRYIQRQNRGRKVRESQFVPSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVB6</accession>
    <name>A0AAD2FVB6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="26803" checksum="6518EDAFEA09C9BC" modified="2024-05-29" version="1">MVPLVNRQVLKLPSCDDRFSTRFSGSDNIPSPCHRRASTVGDDASSDPKKRVHFSSKRRSRDIICRDDYTDEELAACWVTQEERERHYKSFEKTVKRMESGKKAKKDDTYRGLEDFLHTDSIDRTIHDCIDAVMDEQERQWQISINVIDWDRFREVSLEVSTQSAKYALVMAQYDAHETCAAIIAEEDDDSFEGDEFTKGAAEIPQSFKDNANCKQFWHPRKIRSQMQSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVH4</accession>
    <name>A0AAD2FVH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12766:SF7">
        <property type="entry name" value="DEATH DOMAIN-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12766">
        <property type="entry name" value="DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="421" mass="46682" checksum="8CE58D5F97904F0A" modified="2024-05-29" version="1">MDEPNNKRRRTNKVLIKQEPGSTSSTNPSPASLQQQQHHQDSESSARPERTETPIIPAGAPNNSRVRQRSNSTQSHGNNTTSISNPGNGNQSTTTTTTTTSPQNNNNINNNTQDYNNNSNLQQNANNANSQPHHHHQQQQQNSPQQQQEQQKQKQQEQQLQAQRDNIIRPLLRELRTGRTVDAAIKAIQRLYGALMNITTSTGKEADASVQMARCITQWNGCGAILMALKDWYLESTDFACKAVKVLVQITGAVPIAKQFIVELGGLRTLLKVSEGGLHAYSASKNNNNSNANAKGPTRVPLKLTVALEKKLSYQLQSNVVGLLHNLIGGVDYSIGKEVAAEECLDLVIDALKCWPDDKYTQKRGIRYLLKVGRMQDSQVTTMLQQKQVGILFVQALDRFRNISPGVKEMAQEALLWYATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVZ6</accession>
    <name>A0AAD2FVZ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="413" mass="46015" checksum="EE97566979C24A57" modified="2024-05-29" version="1">MAEALVSNPVTTTFSTVSTVSTESSASTTSEPSTSTTTTFDNKNKNNKNHKNPKKTDKQGRERVASDREYGGDKSGFLYKSGIPTLRSSAHRVKFKKKCRKHDPKPTDANGKLTNKTWLPKDLLQEDVFSYSQEEHDLKGAVLALLQQCDAEIVGDFDLNPQTAAAAATTAEGIGSVDDDNKAMNTTSTTSTTTDCRETRLEDFRVPVQSIWRKVNGGNCEDTQKYLSDQVATNEEFLQVFDKFVVQVALPYLKERLLAAVAKEKEEVGGQEGTSTEEDTDTTTPITFYYQRPPTLRLQPGPGWAKVKPHNDAEYGHQNGELNFWIPLTDRQWTGVDLWSETVPQQDDYRPIPANLGQAISFHGSSCKHYVNANASNHTRVSLDFRVGVQGFFDPYWQMKGTTDDHGRKEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX06</accession>
    <name>A0AAD2FX06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="3">
        <location>
            <begin position="81"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="3">
        <location>
            <begin position="224"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1955677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1113" mass="122730" checksum="C0D951B28229749C" modified="2024-05-29" version="1">MDFVLPSTSHSDRKPNSSSMPIVSNRANKKNVGDNVTLTPVDIDVLRGLNKDYVIAQQSGLVDQQAHRAWAFRAALFSITFIAVYMTLGIVFFRSQTDWSLPDTILFAVYSATSAGYGHVDIPSTPLFQMVDTCYVLVGIASLAIMVAQVYQFLLLEASRAQDNRRAAELARSAKSDDSSNNRFGDSLWKLIDRTRSFFRETMAGRILSVFLPLAFLALSGACAIGYIEGWTFVECIYFGVISLTTTGYGDYYPTKTSSILLCAVWLPFNIVFTSIYMGSVAKWYLRISSKGIQHIRTKMQDDIVRRQPLNLFSTTPSIEQIEILDVEVGAEPVIHEVSENSDSADTSTIHDDKESSKSSEEDDPTSEKELLAIAADGGTLVVFENLNSTLITMSDVIKAVETSTATDLFQPVIQSEIADSQRAIAFQEAVHCESSKQPCFKLRVLVQQRLAEIIANDLVGGEHLVDVQDTMIVVQIGQWKEVVAKWRIPSGAWKAFRAATLDAIMLAGERNLIRQGPGALFQLSPDEFHSIFSSLVAAMGDAETLQGWLNSTEHLTEEASAEVGSEILRKHPFYGCTSLLEIEILPTVTIIGEAAFAVCRSLTRVRFHEDSVLTIIGEEAFYECSSLIEVNIPSSVESIEDRAFCLCESLTKVSFHDDGLLATIGFAAFCQCSSLTEVSIPSSVEIIGKHAFGTCKSLTKVCFHEDGLLATIGDAAFYQCSSLQEVNFAEANLKTIGAKTFRNCVNLQKINIPSTVGLLESAAFLGCRSLLVVKVQNGLKYLAPLVFCGCKNLQAVALPESVEGIGYAAFEQCWSLLSVELGDRPRTVAIADMAFTECKSLVNICLPLSASSTTITSTGAIGYTSFGGCTMLENQYSRDANIFPALQRRFENFPMHKKCYHASVTTTNELAREIESSMHSKQEGSTHLVDPFGLTPFHVLLSAATCRLDLLQVLLDAYPPHVLGWKDVHGKTAVEYLTQRSFHLDEDSRQMHRMALQGWMVGCISSWNGLEAWKSDMSDKVNAIVAENDVEHRQFLLREATMALSRYEQVESTTLLELSLWKSEMKFAAFASVDDTERTTVKVNDRETHRIRSGASVVVPNVIAFCYEANLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX33</accession>
    <name>A0AAD2FX33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <ecNumber evidence="10">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS15613</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.20">
        <property type="entry name" value="4-hydroxy-3-methylbut-2-enyl diphosphate reductase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009911">
        <property type="entry name" value="PRK13371.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31619">
        <property type="entry name" value="4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31619:SF5">
        <property type="entry name" value="4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042016798" description="4-hydroxy-3-methylbut-2-enyl diphosphate reductase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1955159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="460" mass="51540" checksum="AECDBBB799653519" modified="2024-05-29" version="1">MKISGAAVFAIAIASVEAFSPASVQQRNGATALFSTTEGSKPRTKKEGRLGFFKSEKFHRKGFKEVRDNVEDTINEQYQSSLVDDLKSSNYVIEKDNVKVYLAKDFGFCWGVERSIALAYEAVRHYPDRKLHITNELIHNPEVNDRLTEMNVNLIEKLGEGKKNFDVVEDGDVVILPAFGASYEEMDFLDKKNVEIVDTTCPWVSKVWNTVDSHQRKGLTSIIHGKYGHEETVATTSFCEDYICVKDMKEAEMVADYMANGGDREEFLKYFKNAVSEGFDPDKMLEKVGLANQTTMYKKETKAIGQLFQKTIMQKFGPSKVDEHYYEFDTICDATQERQDAVTELVENGNDYGLDFILVVGGWDSSNTAHLLEIPHHQGIRSFHINRADCISADNTITHRTVEGEIVTEPFLLNLDKDLVLGVTSGASTPDAAVQDALSQIFLLKKMQDAAKEGSAVKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXB8</accession>
    <name>A0AAD2FXB8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXB8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF4">
        <property type="entry name" value="17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="342" mass="37044" checksum="F350D7C1867CC8BA" modified="2024-05-29" version="1">MVLYFAEAEHYDATSDGSCTAADMAAAGDYPTWVVVLLVIVSLPTILWFVLYSLPQMYMAFRPVPDLKKRYDAKWALVTGGGSGIGKSIAFKLAKQGLNVVIVSLDDKFLKETMTQLKEQFPDLEFRSVGVNFAPGVDYLKAISEGTKDIEIPIIFNNAGFLVTGFFDQAPLGKLLVNMECNATAAVNISHHFAGKLVASKKKGCIVFTSSVAGFIPTPFSGMYGATKAFVSSLACSLHIELQSLGIDVCAIHPSPVSSNFYANLDHKVDLIESASKQAVSPDALPDDIFRSIGVCALRDLGGLALGSRMGTWFLPFNFFTEVFAAAAPFLPDWKTHNKARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXR7</accession>
    <name>A0AAD2FXR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS15041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXR7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051258">
        <property type="entry name" value="Diverse_Substrate_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42920:SF5">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42920">
        <property type="entry name" value="OS03G0707200 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="78"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="240"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1954449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="451" mass="49846" checksum="73301B0CF8A0C069" modified="2024-05-29" version="1">MAEQRRRTVTTSSTDNHNNNNNNNNNNNNSTSNGVDVLSGNSTTSLNNIRQQRRRRTNNRNKKYSWGQPKLGLWGSRILLLVVAAMYSTNFASVKYLETRCAHPPCEHDPSETSFARFLLSAIVCLPILYSNRQHWGLIQAGVEIGFWYTVNYVTQAEALEYIPASKCAFISALEVVSVPVLARVFQGRKMERISIISAFIALFGVAILENLLPLGSFTPPPPVMTGEAATKTFMGIGIGDILALGQPLGFGYAVMRVEHYMDKFQDIPNRVLTLTAAQCVTVCFLTFIWILVDCDGRVPDMTYMFETHYLIALCWTGIVTTVGACVLQGIALQKASATDAALIFSSEPIWGSLFAGWLLNERMNATTYFGGFFIICGCFLGSMAGGHHESPNHPSMMTNGTNGNRKYQGRLKSKRSDVSMSGSEDSLLPTRVNNDNDSNNSDDYAFGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY52</accession>
    <name>A0AAD2FY52_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY52"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="147"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1956897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="397" mass="45477" checksum="0AE17C0F7477E621" modified="2024-05-29" version="1">MFNSSTSSKLVATKGNTSRARRDRRTTRIITILSVSAGTVAIILLLCWRLGVVSTRSSSKSNGTIRGNSASRASYDDYFQPQECAVGLWNQDTHTLEVNPNCPASQKLLNMKPPPTDKTLTFFLIYFNDHHHLAHQLKSWISYGQNVLDQIQFVIVDDSSAPGHTAAEFLQANINHNDSQTIRTPLDIVIYKIDQNLMWNIGGARNLGFWMANTPWVFMSDTDTQVAPETMKYILEKVSSSAAITDTSSPAVYTFFQRQRDSGFKPHPAVMLIRKQDYWKVGGCDEDFVGSYGWTDPHFRYKVQEDPTLHAIKAHTEMDELGITPLREMNDDIECPNGIVCLEKFHGEKAPKEPEKNEAKFKRKSQEGKWSNEVLRYTWKRVKWQQNSWWDFLLWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYN2</accession>
    <name>A0AAD2FYN2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYN2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="309" mass="34226" checksum="FA9F49A291509D63" modified="2024-05-29" version="1">MGSEAFRYCASLQEVNIEEGNLTEIGDWAFDDCVKLHTIQIPSTVERVQKYVFSSCNSLRVMQFQNGPKYLSENAFYSCKNLQSVALPESVEEIDLCAFDDCPKLVSVELTRGSRSVTIHHQVFAECTSLVNICLPSESRLALTNSNKVSLNSFTGCSALHNQYGSTNIPLALQQRFDNFPIHKKCYHASGTTTGELAWEIESSMRASQESNTNFDFLVDPFGMTPFHVLLSAAICKLDLLEVLLDAYPSNVLGWIDVNGKTAVEYLIQRSFRQSERLPNNASNGSSSMVGVFSIKLEHIGSVGIGHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZL2</accession>
    <name>A0AAD2FZL2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS17071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZL2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="445"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="867"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1167"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="899"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="873"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1169"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1958198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1221" mass="134734" checksum="CC3921466E41F269" modified="2024-05-29" version="1">MPSFLPTTKLKKLRASKLEKQESALSRLSNYSGSDVLSPDDDASQGGKSLTLEEENALLDKELDELRKVRENLSSETGKKKKKKKKPSDDASAMESVGTPATKRKKKKSRPSSVSSAAGNEIVYDDDDDQTDVVDSLPISDTPRKKKKKKKSSDGSVVSEMTMGTTGTKKKKKKKKVSADGEDGDESTIATNKSGGTKKKKVRKSKSSRSSDVSAMTEFSADDNDRYSTRASERVSELGELKEGEEYDNAVPPTPGGTRKKKKKKKKLGDEESVGTMGTKGTKGTKKMRRKKKSETSASSDSGTLNDLIEGNTISFDPSEMDSLDPAERSLGMRGISERGERTFAPKARKTRSSSNVSTLREPIQEERPVKMKSKASGGAGVGPTNDDDSAYSELSMSTFDKAAVADVDDELKPIRRGRKSQVANQENTAEEKSSPIQPAGEVDAGTSQFFATFAFEGDTAGSQLSFPSGALITAKPNQDGAWWWGSYNGMQGWFPPTYVTEQQEQTTVVAEPETVIKESNHENDENPPVKLAAAIAVTEEIEEPAVVAETPVVVEEQEEDEEEQPHEQKILMEQDQSQDVDPTIASPIQIEDPIESIVQADPSDDSAHGGIASSDDGQDPATNDVRDCMDTTLDSGEPLVEPIAEPETLASADCIDAEVTEPVEASEPYHQDDSQIPEEAVEIGVAFEVEADSSRINVAAHDSDSEDEASPMDPAIESSEVNADAAGSDVIEDRDSPPLHDQEDETKSSSSESEGQAPMNPFNAAASKINHVAHDLKEKAEEIKENKPVLNAVRGAVEDLKEKQPIKTAVQGLVEDMKEKKPLESMFHEAGEIVAGIEEKVGDALGESEPAELEEEVMSEAELVQLESPVISDEESESSEETVQEEVDEKTMDPEELKKMVAAEKERVELLLEELVQRERENAAEKLELQTENESLSKEKEFLELQTENLKQENEQMDRAIFFTEYQLEDLRDNDEAEHDEMMLDLEDENDALKEQLAVYTNFIRKLREDEYDRLQQGKYRMIEILEEGEDDNSEMDDTIGPARDINLEEKEEVSVASGRIKVRGELLKVSANLKESNLVIEHNRMAIEQLKAKLEETRKDNSVQTAMEEVNGMKDDVKIALLTAMHEKEELQRKIDKEDAAIKEMEAEIAKLSTKQTSIWGWIAGAEESESESEEDTDEEGEEDDNVDALLLSPEESVRKTGDAMMQQKLRESRLLLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G016</accession>
    <name>A0AAD2G016_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G016"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033891">
        <property type="entry name" value="TTC38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263:SF4">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1958282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="448" mass="50367" checksum="6580BF699FDD94D8" modified="2024-05-29" version="1">MQTELPNELHDYISAILGMRQPYELSPKQHDEGVDELMMNESDDDSQHRTLLLFQADSLWNLGESAKSQEIVKSCLEQLSTQRQKQEQEQSDDNDNMHQSFAEGLQSLNVGKFTEALISFRQATAACSHSQSLLKAFFTERAVNIAFWMACTGSMLEASKVLEANIQDTPFCGGILAFAHYMSGDSKQAESIARTAIASGMDDPWTIHAVAHALTSQGFHEQCANWLILHRPKFEDCNFFMKGHMEFHLALSYLYLKDDAKLHALIVNGSLWGTMSEAMKADYWNAAGLLNVLWKAEIRKVISNPLKHEEYSNLVKEALERIDTILFQGDEANVNKSSVFSLCIFRFTEGAMREKWSKALLLLPDNSSTSSSTSINNEVLTRVAKAVSIFYHNGDDDNDDNYDHGSSDSKTETISLILKPITNKLPKLGASPEQRETIDDFVQMMIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0Q5</accession>
    <name>A0AAD2G0Q5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS17743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0Q5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1959321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16821" checksum="951095A2B3669F0B" modified="2024-05-29" version="1">MSFAARNLSRALVRRTPAVAARRNVVTVPRLGTKEQMEKEAIEQIRARLSYQKEIMEANPHKSHAEEWAELWTWIKISIFFCGPLCIFAVTKDLLIEEHHHRPTEGNPEYMGIRNKEYPWECDSCDLFDMDCWKKCRADKLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1E9</accession>
    <name>A0AAD2G1E9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS17924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1E9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="381"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1959503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="592" mass="66342" checksum="DEC7C9613772FAFB" modified="2024-05-29" version="1">MALSNNAHTPTTLQAVKIPCCLCGTMILPNNANQCGTCLAQDFDLKSELERGPSGALHPTIYQCRKCRRYQKTPTYYEACEPESPELLAICLKHIPALHGSNSSKYKVKEASWIWTEPHSMRFKVKLTVQALVQNVLVQQRVAVELHCGWQQCPDCNREFTNRTWTAQVQLRQRRQDHGHKGLMTLEQALRNNASIRKHVLSIDASREGLDFYFLNLPQAQMFSNYLRKIAPMKVSSSLKLVSTDSHSNTAHRKHTITCELVPLCVQDLVVISKSCKNNKLAGRLALILKVKSVVHAISASPVRQNLEQSMVEVSPDAYYKYEKSYRVLQASNRLTRFTVMDVELCDEEYGGGGGGGDEQQQQQQQQQQHQLYKGPNSGIEKYALADVQVVRESEYGDMNAEVLCCVTHLGHLLQPGDVVLGYDLATFVGDGDWDAELNNSFVVPDVVLVKKVTPKKGELDAIATGTTSGSVSNKETLEPKHKLSKKKQRRRRRKENRKMKELEERVERMGFLDDENVGGEENGDEEEEEFDQDLEEDPEMAAELQALEQDFANLEAQQGQGGDDNGNDGNGNGNDDGKGVQAQHEVVEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1V9</accession>
    <name>A0AAD2G1V9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001983">
        <property type="protein sequence ID" value="CAJ1959264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1V9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="47316" checksum="F5C83A50C0AC3E03" modified="2024-05-29" version="1">MLIVLVFDGRRDQQNSEGQSLHPHGKRLTSEEEHPQYPSLAEPFIPDLESVDLGPEGKYGTLDKENSQYHCLVEPFVNDLASVDLEPDPVVDLRTKRRHGTLDLSSVDLEPDPTVDPKSKSRHGTLDDNHVQYPCFVEPVATDLASIDLEPNPLAYRACLASLATLPCKKSLCTAKLEAAGSNNQPPAQPPPSPQHPVNLHEMLTTTDFLSQFQHSSMGRGEDADTLTSVTSEETNSDNLVAGSEDADTLTSVTSEETNSDKLALVPATKYRKATQEVKNYKISIDGVDVDEWAKSVPDDGSAGEQSPFDRVDILTKRNTTVTTLKDSPALDDAIGFFETHHCVMPTNGLYKLHPGQASDLDWLECNMAGLFDLDPAHVPQLRPPDFEAYKSGRQPSVLFVPETPINFVIESTPLRDKPINLNYKLSPSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2U9</accession>
    <name>A0AAD2G2U9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2U9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="353" mass="39275" checksum="79FD2990808D50EA" modified="2024-05-29" version="1">MPLISEAPLAHDHSYHQEMKENSSTSEYSSETMPSSAQVLVQAAAYRIDLDPSKLSFLLHAMNEELVTELWQLQYMDFPSWRELGFPVGLIASIRALLEEEESSDHEEAANKNGAHRRAIASDNSTTELAVPKATWQQARMRASEQDNRGIKKRLSDITLSERFSFRTSIMSPPSSKPKSGSPAGSPMYFSVQSKSQKSEPRSNRIFMPVADIPPTSPPRRSSSRSKVRSPMQPSSRDQHQEKTEEQRRRSSFEMPLRPSRRPTITDLESLFQGIGEKYLASSSDSVGGSMTSTSGGTSIEASLALESLLRSGESEENKDVREKSMDTIITGNLRGTADQDDLGFLYAEDFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3K9</accession>
    <name>A0AAD2G3K9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS19020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1961061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3K9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041897719" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="11">
        <location>
            <begin position="35"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="459"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="724"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1961061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="769" mass="83934" checksum="F2A39340BC8C80E8" modified="2024-05-29" version="1">MCLSGFGSNCVRASSSTILFLLLLVQVCVCSTRAQSETSSSAPDIVAIIPDRSTAYPNGLHNGLLSSVRRYNVSLEIREIGDFNSEKSLLVLQEAIDSEVQPRIYCIWPVDIPSRQLMKELHDAHGVPIIQLNQLPSEESAWEWDHLLGYAGPSDALRASNAGLMMIDSLIEERGLSNPKVVALGYPGSYGGYHLSIAAFRQSIEDSSIEITHDLPLDWGNQPAYEAMIHLMDELKTTGQEIHGVYAMDDNILIGAYEALNDRGRLDGEDAVTLVGTVCNGHRDILGQGKQYGTTIQSPFLEAELAVDSAIEYLSTGNLTTIIRFTPNPIATTDTWETMLVEFLGEAYVADRLCTWTLQHERTNGLKNIEDADDPCEYVDCLFTPEALFLVGYVVAAINYALCVLGLALLYMYRKKKVVSIAQPFFLTLILVGALVDTTSIIFMSRDNLGYSKQNLDRSCMAWTWLLGMGQMMTTTTLVAKMARVKAVIGIGERAAIRRTIVTVRDVSGFIVGGLVLDAIVLTVWAVQDPFHWTISVVSRDFEGTILQARGECSSNGENFWVYPVVLILLHLAVLIYGNILAWQTRKFHQISDSRMVAVSLFNSIQLLMVAVIMLSLSGDSVAISYVVRASYAFLNNAGVILLIVGPILYKCMVGKGNVMPNIHDVASRAVGSRDSIEESRTYISGFAIPTSSGIGQGSSRAFNPISETEVDLFGQSEGNGLSSNTASNFGMPGSKPGIPESAQESKSSRVDFTGTIDNSVNRSQSTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3U9</accession>
    <name>A0AAD2G3U9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002048">
        <property type="protein sequence ID" value="CAJ1960180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3U9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32612" checksum="D642DA51ACDB7F04" modified="2024-05-29" version="1" fragment="single">MTHEKQKGLVKCWTDERVGITLLAEVNLQWSAVPRGQKWFDQVKSFTDQGHFSSVSYYKHQEFPTPSAHQWGGCSATLLNKVARRAKSRGKDETGLGRFSWIKIRGRDIRQQESQTDGPPAGPLDLVVVSAYRPNKEGTNAGSVWNYQRNYWLSKGVTMDPRDKLTLDLVDLIKQWKAEGCEILLGLDANEDVSYNSPSSFRQEMRSEGLTEAILRRHQGPYPATTQSRTTDTPIDGIFVTDSVRVTAGGYLDFQQYFKSDHRGLWIDIDLEATLGAPAVTSPSFQPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G465</accession>
    <name>A0AAD2G465_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS17819</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G465"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1959397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="401" mass="46808" checksum="7D792B58C959C9B3" modified="2024-05-29" version="1">MPSKNEIDIDPYQTLGLQPGATDAEITKAYRKLALKLHPDKQANKNLSPAEMEAAEQRFHNIKEARNFLLENREERQKFDRQKASEQKRKEAEAQREKTMSANRKQMRDELLRKEQQAKQASLNHAANKKNAAKKRERDSVVDQLRRDGTKLRKEYAEREADRQDDEELEQEYRKQKRLAKEQLENRQVRLKWDRKKMKTSPSEESIAQLFEKERGFGSVETVELLGNKGNQALVTFVEASSCRPCVDFYKNSKEMRAKFVGARKDTEEQLELQKEKEDEQAEKKAEKRRRTAGRENETMEERRLRQQGERETLLRQMEQEEAESGDAASRNEEMNRKSSHAARSDTSGDATEPLIRMPLEFPKELLATGKTPLQMLEEMERRILGDLLTPEELKSMQVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4F6</accession>
    <name>A0AAD2G4F6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002111">
        <property type="protein sequence ID" value="CAJ1962542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4F6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="531" mass="60545" checksum="78F0C23C91CC06E4" modified="2024-05-29" version="1">MIPRDPHFTSYGDASFLGGGAYSDELLFWFRIVWSPAIVAGTKLKASNPNYVHINSLEFLVAFLQEIATVVRLEGTSHAHPGLAHKFPNGFSQFPVLLNRTDNTPTEKWMNDARTNSPFARLLVDLHGQLLKRSPLTALSDHIPDISHFTLDEKLRLFPAESRTLLRPALLSILQSKAGATDDPRKSGTLRSRRLHFLKFCYDMNLRDDYLMNGPDFPHERRVATFALYTVALATGRTIKGQYIKSATIKQYLHAAASFICLFTGRDPRYNNPSDTKMSPDIHATIAEVERHENVPNKLEPYTLDMQQHLEHRNIDTKAHRDGLWKTCEDWNSIGLLDGHRLSEYAQTSANKNIGDQATFDGISIAFCVKDVTCFDKFKRKVSISDFLQNPDLVWRIKTRFSHQKNGNHGEEKLFIRSEKSPLRCYIRRMHSILSRFDRLIGITTTNVPLAVYQDGARVLFLHDAEITRVMRHVACSLYNLDPKQDKTIAIPTISLCGGGCFEHFFHLMVQQMIVARDMRDFQISCSFFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5V4</accession>
    <name>A0AAD2G5V4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5V4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="362" mass="39995" checksum="40701692E598B2FD" modified="2024-05-29" version="1">MDKSPALKAASANTKKQGVAKSKVSSVGKKAMKKQLEIDLEQPKHRDPVSSNDVDVKQLAKDQDALQSANEMVAQRIAEREARLGDHYDKLLAKYLISLFNLSTIEDKVAEDVWSLRVLAIQISLQNPFSFFGIEEFKEQPHDNQFFDGAKSDPRLHLENPLVGFWSICSELFDYPWATITTMTHLCLSSVVSNKNVQHLLNPSFDHPVPTNTPNSALADNDVSDGDGVSTDGDAEADPMTVDGREILDDDEDNEVQVTGVCHNPRPSLSSNDDEDDDDDNEDVTSVQMKDAGEGEEREGPTDVAAREDQVIPQNRFTPVASQNPLPTTNSRLHRPLTVVEKISRLTQVNLETSLGNATFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7Y7</accession>
    <name>A0AAD2G7Y7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS21146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7Y7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="167"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="253"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1965505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="504" mass="56601" checksum="4B4A2D81594D76E0" modified="2024-05-29" version="1">MMRISNHSRKRQRGGGEQKTAEYSSTLFQFFSNNSKCLQTLCLLTLCQVVLSAYHYHNVYKTTKTFSSFGSSSTSLQFASSGNSAIPKHHPSSPVNSALHVSFAASAAANARVESVAANPLNTYTNTDKDGTTTTTTTTTTILPEWNELSGAAQTELQQMLNWDKVSTFDYPEIFRLDELTQGHSLLFMSWAIVASPYSQPLLLSSSASQQEQQEQQDNEYCNLLDAFGISPTAFMDYVRTIEQGYQKNNPYHNHIHAADVLQTLHSMLQSESYRLTKVQHFSLLLASILHDVGHDGTNNDFQVQTQSQLAIRYQNVSVLEQHHVEVGLKELDSSELLDHLPLQQRDEIRQFIAQAILHTDMAKHQEQVERASQAASTPPPPPQDDDDDDDWQAAMYLLHLCDISNPTKSTFSIWTEHVLEEFYQLGDLQKSLGLPVSFDRSVANSNSKVSIQQGFLKFLVLPAFEAMEFSNPKIMQGLYANYEYWMKQDKEEDAETAAEAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8Y2</accession>
    <name>A0AAD2G8Y2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002287">
        <property type="protein sequence ID" value="CAJ1966435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8Y2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="130" mass="13658" checksum="C7E538D34A5DA15B" modified="2024-05-29" version="1">MPPVCQTQPNESVQTSTGGQLLPDGSVLAPGRNGVVIGGSPAGLSLLSNISSITQLLPAAKSVSIRSSVPTDLPEELVDSDHEDALDLDELDDHSIENEEDFQHLNCEAEEADRILSGTGFVTPTMIIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB56</accession>
    <name>A0AAD2GB56_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002322">
        <property type="protein sequence ID" value="CAJ1967289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB56"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042072313" evidence="2">
        <location>
            <begin position="23"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="435" mass="48786" checksum="B8595652A980272D" modified="2024-05-29" version="1">MWQSLLNLLILLLLLRVASVFCKKAEPKKGIRRFGPSNRQQQQRHRDGGGRVSTEDPLVIFPLDDKLEDTTFFNRFWDFTLEVEPRLLLEFRPLAKVWAIAVELLGHPWTDPKTTTVVTEFSERRSAAKGRKRERNRDPSTARKPAPIDPRSPARGFFPEATPKPVRDSIAPDKEDAVMVDTTGPSVISPTNKPVNGKFAYWSDNDGSESVESAPAFSAPSHSDHPPTEVVVGNSPAPTQRANDPSATVLVDSHLSKTEPPNPPRPSALSMKQQLTYVAASQKKAAIWTKYLSEEMKAREVTQMNLTGLPRSNAQFLCATINYEWDGDTSEGGSIEKCFTEEMVSVLSMAMDSAESNLVILPVSELRVRDKKLWLTYKEKVEELTYKKLKPYIDWSWNHGARFGYNAKNPGPKTGRTRIRVAHNSSLDDMSRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCQ5</accession>
    <name>A0AAD2GCQ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002433">
        <property type="protein sequence ID" value="CAJ1969852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268:SF7">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="234"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="473" mass="54145" checksum="23800D6376C30DDC" modified="2024-05-29" version="1">MKQSVVACLPNEMRTGKVAAEDTVDLMTMDPGQHRSWRVALYYCYIDLSNVPDHVEFHRHLCKNLSLKGRIRVSSDGLNGVLTGQLVDLKQYEDKVLKQLLELGTHQSQSNMIDLNTKYCFLREDLPILPQLFDKLICKETSSVICLFDNYQPAGTAASSTKENRNRRSKQNNRRVRRKKQRQEEKKHQSDKDISEERATLVAELPRIQNAMMTLSPSQHLTTEEWNDKLQNADGENALLLDVRNVYESRVGHFSVSNVPTLLTNTRKYSDLPELLAENPNMKDKEEVFMYCTGGVRCERVSMMMQAMYPQTKVYQLKGGIQTYLQESNNKQMCLFKGKNFVFDPRRTDPVHLGETVGRCLICEAPHDDYDNGHAPSENKEARCNTCRMLVLICNQCRPGYLCWGESEREDTKSDGAGLEGNRSKETRPWLYCAIDSLPKPAITSFANGPRDFELSLCVEETTMIMIYFFCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCQ8</accession>
    <name>A0AAD2GCQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002458">
        <property type="protein sequence ID" value="CAJ1970096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCQ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF498">
        <property type="entry name" value="DNAK FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30708" checksum="1098749A48D8FC49" modified="2024-05-29" version="1">MQLIGILRWLVELGRMDVCSEVSMMSLYNAMPRVGHFHAVLHLFGYLETHPSCEIVMDSAYMALTDIPKSEWHEFYPWAKEVLPPDMPEALGRAVKIVMFVDASHASNNLVTCQSITGVLILLNHAPIVWYSKKQNAVKTSSFGSEFAALKTGVELVEGLVYKLQMMGVPIDGHCHTLVDNNSVVMNASCPESVLKKKSNSVAYHYVRSKCASDLIQVAWEGTKTNLANMLTKIHTGRERARLVEFIMYEEDKMLRVVQSTIKALNVLFGLPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDD5</accession>
    <name>A0AAD2GDD5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS23220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002380">
        <property type="protein sequence ID" value="CAJ1968399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1968399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="31869" checksum="A4BF4E220F323F1E" modified="2024-05-29" version="1">MEEMNLNHKEINNLLLVLLKEALAEGNFVCVRLLLDAKGFSSVHADNLLYLACYQGHLEVAKVLVESGYHDNHVQVRPVANRVTPLHFACIGGSLEVAKWLVENGADVASKDDAELTPLHLAFLQGHLDILTWLVDERGADINAKSISGKTPMHWACEGGYVAVAKRLFEKGADIDARDDRGWTALHWASFRGQWEVVKWLVEEGSGIDAKDKDGNTALHLGCEKGHLGVVKRLVEDGADVRSKNNFGLTPLRTACNAGHMQVVNSLVDNGADVGAKNLKKIATFLLRVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDH7</accession>
    <name>A0AAD2GDH7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002527">
        <property type="protein sequence ID" value="CAJ1970514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDH7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="186" mass="20703" checksum="740972F42B79B131" modified="2024-05-29" version="1">MAVVVGDMARWRQAGLETRWSATGPSVAWLGKLSLAIGMASGSSVAIDGIFTTSGVPVLASGYNAFGKFVEADHWALWIDINLNTALGNFKPQESTFKPLKLTLLDRQSVRRYLQLVHLGYKEYDIPSHLTRLNQRIENNERQMSPLLAHKYNCLHWYGGLLKTIVALPHPARFCGLQSCKDFGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDJ1</accession>
    <name>A0AAD2GDJ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS23776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDJ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF411">
        <property type="entry name" value="OS02G0248440 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042079227" description="RING-type domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="379"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1969566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="834" mass="90511" checksum="745D15D84A0000A5" modified="2024-05-29" version="1">MIPRSLVRAIWLPILLIQSSLLPFTEAEEAIITLLENPAWSYRAELADFGYILDQRLRYNANFMTPPMDETQLCSFPNFALSDLDRASRLSKPVALLVSLGGCETGQKVEVALEIHKKITNFLRFIVFYNNDPNNPDEIFKVNPPINTTTYKDDLDEMSFSAVSTGTSSAILAHMQQFSALSGKTSNFLGPSSDGWMLEMIIETAANPFDKTRTTTDRIGSSNFYWFRIVLFALLVLSPFCRAIFLWWTGGGRIRLRRNENRRIVGFLYTPPMAYWFVSHGTQEAEPVADIMTREQVMALPEIVFKPPPPSEDTANDTGATDVSTDDSDDNDALDKREECADDGRLIKIVDRTSVTLHSSQPVELSSEDGSPRTTCTSCSICIDDFEAGEKIRLLPCGHAFHTECILPWLTRRQGCCPMCKKSVMGEDEDEESNNTAAESAPFSRCLENSSGVDTIEESATRSVDRSVAAGDAERSRGNNGIGGIYSISVEDPEAGTDQVVNAVVNGFDSPSYDTLSNGIDIEIGEGKMLLPDNDDAAASVENSSNVESGLPEMKTSEADAGSSNLESNLPEMEESGAGANSSSVESNLPESTESEADADRVESSPSDDVERRNGNTLPEEDISLPLKSEVEDAKAGDKDQNDSLSATEKEMGASFDEREESVGETITGANQCIESSPTDGEDNPASVKLSNGIKSTTASSGDPAQVDSATELEFQQSSASNLPKQETAGESSSSSHSAAPSISEAPIANDDQEVVYQAEPQIADTSSQQSPVVENDKTAFITRPDSDIQDPNATTSDSMLVEDIPVQGSEYNELLKQPEVQETGDDASKEDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDR0</accession>
    <name>A0AAD2GDR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Malonyl-CoA decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS23988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002439">
        <property type="protein sequence ID" value="CAJ1969964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050080">
        <property type="term" value="F:malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001294">
        <property type="term" value="P:malonyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.150">
        <property type="entry name" value="Malonyl-CoA decarboxylase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.90">
        <property type="entry name" value="Malonyl-CoA decarboxylase, oligemerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038917">
        <property type="entry name" value="Malonyl_CoA_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007956">
        <property type="entry name" value="Malonyl_CoA_deC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042303">
        <property type="entry name" value="Malonyl_CoA_deC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035372">
        <property type="entry name" value="MCD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038351">
        <property type="entry name" value="MCD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641:SF1">
        <property type="entry name" value="MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05292">
        <property type="entry name" value="MCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17408">
        <property type="entry name" value="MCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA decarboxylase N-terminal" evidence="3">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="2">
        <location>
            <begin position="169"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1969964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50524" checksum="C08936D4D2D341A8" modified="2024-05-29" version="1">MAKIVAQLSRLLDQMSKSTLQDQVRKHDLAIALRDQYMELPRSSGNPIDKETYEALLLFADSSSLGDDSSVSVSQVSYGDDFSAPPRRQRRSKKSQFDRDSILVDCILSKDVQKGMEFVVTMREDIFQSRKNFNSSQREGIGQNKFVNLKELDNDLKQCLRDWFCPNMMDIRRISYDNSAPSVIESIVQKEAVHPIQNPEDLHDRLGQGKRVFALFSPLLPDKPLVFCHVALTDEIPCTLEHAAASSQEDDPKVATFYSITNGEPGLIGLQLGLGLLKLGMRALQSSFPSINEFVTLSPIPQFKAWVESHIKNTFDENSEAYPRSAPRSTKVFDNEVGCELMHMCQLLGEDDPRSDTFLAKLEAAMQSDFGTNETQRAAEHLLFKLACQYLLQERDGRVPKCRVARFHIGNGAEVFRINSKADLSRRGMNQSYGFMVNYRYDISNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH36</accession>
    <name>A0AAD2JH36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chlorophyll a-b binding protein, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS12319</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1949895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30842" checksum="1FCA200ADF915055" modified="2024-05-29" version="1">MTKRMTPVSKMMLRSFMTAILSSSSSSLLPLRPTKSPIFALALSSSSNNNNNNNPMSKLLPIKNNNNNINKAPLALSEELGCSPTLTALLKRTPLITTDNSNKNQQEEPFYFDPMGLATDENFGRYREAELKHGRVSMLVVLISIVQTAFLVKTPIAVFLEPPHLWELAQTHNWFFVPKVLLVTGILETLLLVQASPQDMPGDYGLGYFGVRDKGQNERSLVCELENGRLAMMVLLYFALNELLGPSVSISNLPTSLPLLFQELQKWAKLWASITAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH98</accession>
    <name>A0AAD2JH98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS12617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000034">
        <property type="entry name" value="N-alpha-acetyltransferase 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1950514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="175" mass="20479" checksum="BC4BE63DC3E6E337" modified="2024-05-29" version="1">MTTIRQFKMDDLLKFNNINLDYLTETYYMSFYMSYMSQWPEAFTVAEAANGSLMGYNLGKAEGYGKLWHGHVSAVTVAPEYRRLGMAKTLMDDFEDLCTHTYNAYFVDLFVRKSNHLAQSMYNKFGFSTYRRVIGYYSGEMPEDALDMRKALPRDKNKESVIPLDHPIYPDELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHX4</accession>
    <name>A0AAD2JHX4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="424" mass="47842" checksum="4B734F5BA2DB3863" modified="2024-05-29" version="1">MQIRPKHKRRIQEENIIKMTSISAPESHRQDESFLRLQSHVPASIGSTSSDIEELELTVMRESLPPEIGNLTILKTLRIVESPIVLRSQELSKLKCKDIESLEIRCLFEESKLVSLPIQIWDFHCLQSLTINSPHGSMQCLPMEIERLTNLEELDVCNHELRLVPVSLSKLTKLRSLRLSATRLQQLPAEIGKLSNLEVLDLDMCSQLSVVDFLATATGLENSLKVIRVTHNVQLRSSSTQPFQQTARLAQLCQFVKKCKGIEVIDLKGNEIGNLEGFQSLLSSELQSTSRLRLISLKENPIIYHSLEEEDQARLAQLLRVHRSLGSFGGGQTIEGDRTIVDKVVDAIVLRSWACPETNHWIELNRTGRCLVMNQGQPTIALSVWPVVLARANHVFSKYRAKKRSANAIYFLLRNNPELLGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIJ5</accession>
    <name>A0AAD2JIJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="25085" checksum="F8CC67909F0DC8A1" modified="2024-05-29" version="1">MQKNEDDVLVHSSFHSLPKRTCLVRFSAIVDQDTVTDTDDKIESEAGDQSNVADDSTKSALQNALEGFPLGLFRKDGFKKLPPLRFEDLDLLFYDVFLVVNLSLSISFWVTHRVDFSYLPVALNEGCIFSLFWILSGLYHGAFLMSAVDGHYGSSDAAGGPKAAAALGLNTYIGAVNMRLVFALASAVLHHREVGVNAIEELIPLEIGCGIFLMTMWRALHSYVAPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIK9</accession>
    <name>A0AAD2JIK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIK9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="366" mass="38584" checksum="A19310A3FF3B192B" modified="2024-05-29" version="1">MEDDSNTSTVSTTPRTSATVTLNPPTTLPLTQSITRDSWCSEWMSLCKSRGLPWNNNHRRWAAPAAPLLELPEVLVTTSTHSEGSYAEFEDMEWKAYCSLAAVARMEEDDDAAVSTEVTACGPPLALKLSIHCSLPHTGIGSALFLNGQDAALIRASSIVDATGQVVLHMVNSQNVSFAILSGPGEIQGSVRQSKIIGSQQCSVAHCTTWIGPSGSPCASLSEYEKARLQAINGILPVATMVRGEGSYAEFEDVEWKAGSLAAVARMEEDGDAVAFTELMNCGAPVSINCPPPHIGSGSTLFLDGQDAALIQASIVDATGQNSQKVSFVIVSGPGEIQGSGSGNSKPSNNTPWHIAYHGLVRAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ63</accession>
    <name>A0AAD2JJ63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RapZ C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053931">
        <property type="entry name" value="RapZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22740">
        <property type="entry name" value="PapZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RapZ C-terminal" evidence="2">
        <location>
            <begin position="256"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="422" mass="46593" checksum="FFB0AF558E4D3938" modified="2024-05-29" version="1">MGDVAQGNDEFFQVTSDSKNLSSAKVKRVYIGGLPKNVPTLEKDLTDWMQSQVPELTISSITINEGGKNPHALVDCGKFANQAISKLHQQSFQGRKLTVQREKRKNNKKSSTGNDGKKQFGGWSKPKKPQFKPISMEEAGKNIQSVVSEEMKQAENAGEDTLNVAIASTAAATFLAAMNGIADPVGDLGDPEGPVNDEDPDQSTEDKGFQLKAMSDLLADFGQADPNWQKQRVEETAEDAGSSDSRLARKGKAPIHIVLGSFGFQNGAPKRPEGWSYSQPLAIMDCREQFESVPKYLEWKTGLSGAVKRVLQQENKDIQKHARTTVADQVWGCLLEAQNAGHGYASPLEMTIYIGSETGKHRSVVICEWAATAVRKKLRANDKGVIQHEVSVETRHRDIDRFRNNSNKQQQQKKKHDFAGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ75</accession>
    <name>A0AAD2JJ75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS15276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47852">
        <property type="entry name" value="OS06G0298400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47852:SF2">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="3638" mass="393487" checksum="8DF5934C0107C3EF" modified="2024-05-29" version="1">MASGGPPPAFGFRPPPPPNGGGPFRPPPPPGRTSSYDSEGEEGGALTSTINLVTSAANMLFKPPPPPSSGNAPPPPQSMPPPRQPPAPIEATNSMLDTPAAAFQAPPPELDLRTTPRSQSNTPQRMTTISGVPQAAIPTMPSLSATPTQFPPPRSTAEGLFGSSTEPTSTMMPQPGASPMAAAMAAASTSSPQNVFQAPPPPGNAASGFQGPSPIMPQPGASPMAAAMAAVSTSSPQNVFQAPPPPGNAASGFQGPPPIMPQPGASPMAAAMAAASSTTTTPPSSFQPPSSPANNNNTQQKVRGVINAVAVANKFMKMSPKRNQTASPVPPASAGGFQPPPSSDAPTLRGTIGAVAVANKFMSMANNNKSKTKEQEPPASPKPTSPSPLRGVVNAVAVANKFMKMKKSADDEPPEGRDNGQQFQDKQQASPAQQLRGAVNAVKLTNTLKGGSESSTQDKQQPSPAQQLRGAVNAVKLTNTLKGGSEEPASPAQQLRGAVDAVKLTNTLKGPKEPSSPAQQLRGAVNAVKLTNTLKGPKEPASPAQQLRGAVNAVKLTNTLKGPKEPASPAQQLRGAVNAVKLSNTLKGPEEPASPAQQLRGAVTTVTASNSLGASSPKRPPIQKFTPPPSPRVHQVSTRSPKTPLIANTLPPSSSSSQTTTPIRKLNLPTPSPRARTLVAGITTTPHRQLRLPPKSSSTTSTSKNTTPRSKFRLPPPRTKSTTPEPVVNLKPKVDEAPSMPETSAASTSSTTAAPGGETIATQAENSTSAESKSTEQSAAAVEEAPTPASAFMEPPKPAEDALPEGWVATKDPTLGKIYYYNTETQETSWEKPFPQAPSTDNTIEVLSQLNKTSTEATAISSAAPVEEEEPQTHDATEWSEVTDPASGEVYYYNVVTQETSWDRPAAMDQPPVKESETVSAADSKEEMLAEESVEETVAASLPQAPATDNTIEVLSQLNKKSAAATAISTAPSVEEEETEAKYEWSAVTDPVSGEVYYYNVVTQETSWDRPAAMDQPAKESEAVLPASDSKEEISADESIENTFAELNAEFGYVDPSETADEKEEEPTPAGSVTEEKDALPDGWTEVVDPSSGETYYYNPATQETSWEMPAEEPKATKVTEAPSTDTTMEVLSSMSQQPEELAVPALGESPEDDGDLPDGWEEVVDPNSGDVYYFNSGSNETSWERPGAEPANEKSGEVEVVASEEMKSSAPAVEEAAEETAGLATEWEEVIDPNSGDIYYFNSVTNETSWERPSVEQMNGDSVELEPTASEDVQLEEPSELGVDPLVVASESEDAEADTESSDLPENWTEAVDESSGQTYFYNSLTEETSWERPTNDEAVLEEQEEIHEDDPDKNVVSDFKTGAGLNTAVEDSVFPADWIEAVDESSGQTYYYNTATQETSWEKPLITSDLRDEVAADATDDRSETEDKQEDAAVNETTPETDDGLPSDWIETEDGNGQVYYYNTVTNETSWERPRNERDEDRGVDEVEQEGDKAEADGVDIDEGDNVMDEDPADDQDELPSDWVEAVDESTGQTYYYNTVTQETAWERPPMASDGQEKDAGDADEAEYSTAEDDQTDGVVDDSTPTTEDEMPADWIEAVDESSGQTYYYNTATQETSWEKPLTTSDARDEVAADATDDRSETEENQEDAAVNETTPETDEGLPSDWIETEDGNGQVYYYNTVTNETSWERPRNERDEDRGVDEVEQEGDQTEADASDDDEGGNVTGDYHDQKGDDADTDEAEDHSAAEDAKASAAADESTPATEDEMPTDWIEAVDESSGKTYYYNTATQETSWEKPSSSVLEDESEAVEQEEKAAEVTDEHDDLNAEVDAEEADEQQLLGDWVEAVDEQNGQTYYYNPVTQETSWEKPIVDSAEKAEAQEEIPVESSEAEEVPEETDAGDAAGDWTEAVDESTGQTYYYNARTEETTWEKPLVLQEEDEGHEEHIGDDTDGDAEPSAEAEDQNLADEWIEAVDESTGQTYYYNTVTQETSWEKPSSLITSNESEEVADGDGESENSFDGQESDNMKGAGERSHPTNDVSESTDISAHDPDDDAPTTVLPECWTSAIDERTGKTYYFNSLTQETSWEFPRGSSDGEASVGSSEEQDVTDSVPAETPVEKEDEDLPENWSKEIDETTLKIYYYNNVTHESSWKKPGVETDADVQDSEHTETEHSEHDPDLQASDDMCKKEGEDQRNEDGETPQVDWIEAVDEASGQTYFYNTVTGETSWEKPVELMQSDDEGDKDEADDGADNDIDDAAPTNTEDDNEQDEGPGLPVNWTEAVDESNGQTYYYNTETQETSWEKPVFTPSETLNDIADENELPAEEFEGEVQDASPSPTVDEPDMRHGESGFPSDWTEVVDEASGQFYYYNSVTQETSWTKPSVALDDAAPEAAIDEMLPLTDSAAEESSIHFEEPESEKVVDADNKELPEDWIEAVDEGNGKTYYYNTVTQETSWESPNAALEEEIAATPESNENLLDESVAAPEAAETNDLVVAKATENIPGDDLPSDWIEAADESSGQTYYYNTVTQETSWEKPSITLKEAVSDVADETPNAAIENATDTEDAATDGSEDNRAKEDEAEDHGEELSGDWIETVDEASGQTYYFNTVTQETSWKKPSKTVEEDEDVVDEKNKHVGGDGVVEQADAVEGKMESDNDDLPSDWIESMDESSGRPYYYNTVTQETSWDRPSSNTAMEDAAEVADEIQDTLVENPADADVGEPLTTETAVSEGIVQEEDPQREWIETVDESTGQVYYFNTVTQETSWEKPSSLQPADKGHEEDSSGIADETLFSEKRMEDDAIDVDKTDAAMGNSLDVSQESLPSGWVEVVDEDSGNVYFYNSETNETSWEKPSTEPSEPIAESLPNVLADEEDIVGEASNQEWEIVDEPKDDIVIMDDTKDTDVDLATHIANLCDERGGVGIIGPLSLSEDDAVLSYIKLKYENTRNPLWGLIDIAARSRGRLRSEDGVADRNSPESSIVELLLRESNGKSPAAPSSKQQQSPSPAEEDDDLRMERVQSLLLRGNRVEAVKEAVECQDFATALLVASMCDPETYKFAAKAYAENVFVGGSPMYTLGMLFSGSIQVPSESSSNSFWGIGANELNSTWKKHLAAVISNRTAGWDRVVLSLGDRLREIGAIEGAHFCYMVCGCPFTDPLDPTTRVSLLGCDHVDKSVVCLATNAAIDSFYQTEAYEWAKRRGNKNATIKTFQPFKVIFATSLVDFGFEDSASLFTLGIRHCSDIPSAEPIDLAGEQWGQVFEDTNALAGAFCALEMRLDLVPDQDEPEYDHVEDEVPPAFEGERPAAMNPDDSYAEENRDAVNSTLNLTDNDATFVTAASNLMEKPGFSMTPQRETPQAPTAEAMVLQEPDGMVPPQVERLSTVAPPVAPLKEDVSRKRTQAMPPQMPPTPTARNNASNNEDVSTPMPADPTTAAAMPAMTPQETMKQPEKAPSTAPSVMMGKKSDAKVNKKSAPSSTEKPRSGGLLSGFRSMMIKRFNKDAVECSLPDNEEKAYYDEKLKRWVFPGDDLDELAKPMAPPPLMPSGGDSKPAIEPEPKPDSNDPLAAMMAPPSRRPAALRRPGATPSMPPGGGGMPPMPGMPPMMMPGMPSPAAGGGAAAPPQFAVFTPSKKEKEQTKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJD6</accession>
    <name>A0AAD2JJD6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001885">
        <property type="protein sequence ID" value="CAJ1955421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJD6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="413"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="582" mass="66142" checksum="9228D3E2340FC508" modified="2024-05-29" version="1">MNVTINYSKCSDGRVPLEIITGITPEITEYLDFTIYGWVFFRSDGGLGVNHIGRWLGVSHRVGPMMTYWVLPKSGIPISVDTVQMVTNAEQQTDSVKQQMQRWTADVSKIVDAKSTYINWGKEEIPHQMMFDFDDKDDELMRNFGMLINPETLEDGDFEGTEEAADDLDAQDYTNMEIGLRRGAEGKLQRAKVKRRIVDENGRPIGVASSIQLLDTRQYEVEYADGGTEIFAAKILAENLLAQVDKHGHKHQLMEEISDHRKNAKAITKSAGSMLLPSGQTRKRQTTAGWELHVIWKDGSFNWVTLKDMKESFPLEVADYAKLKAIEDEPAFAWWVPHVHKTRDRFISKVKSKYWERTHKYGICIPKSVKEAIQIDRENGDTLWQDAIKMEMKNNQVAFDEFGGDIKKLIGYKRITGHMVFDVKLGENFRQKAQYCADGHKTEAPAAVTYSTVVAQDSVRILLTIAALNGLDVQCADIQNAFLTAPNLEKCYMIAGPEFGDKEGKTFIVRRALHGLKSAALAFRSHLAETLENLGFYSSYADPNVWMQTAIKLDGEEYYEYILCYVDDILCMSETLKMIWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJR1</accession>
    <name>A0AAD2JJR1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJR1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="520"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="669" mass="74235" checksum="1FD02EFD7C4A55C7" modified="2024-05-29" version="1">MSALRQLKKGVTKGVAHTTRFAQGAADLVKDGTTDIIKGARDGIREGLSDEKSKELKRSNSANFYEESDDDDDPDISSMRYSTVVGSGGAKKKKDDQNMAGYSIRPPNHAHHDNTGADSDDDLYTEPLSESQQGELGLNDDDDDSAVATKKKKKIKKIKYRKSGDDSDGSDASAKSTKSSKSSKSSKSGKSRKKKKDRVKRSDGSVGSGRKKKAKDRDESPTRQTSNASLKSETSFKKKKKKKMEVADAYSSDDHDDEQLDELAPLPGGKKVPVLPVRSKSPSGSPGTKKKSPAAPVSPTSDDAVPVHPIKQELMRFSDIWKTQTEDDTEEASPQKRESLNVGRISAALGELNGEIKEDDEDHYSNDFLDAKLRSTEQKLHDSEGKVEELIIAKNEIQKELDEEQLRNDELSRKLLFLEDRVEELEQEKKELEDNPKVIEHEADPIEIFELQQEINTLKTDMSIKVDQHAEALHSKNETIKELEAKLEAGGGAAQPRDSLHSSMHSTNSAGGDAKTQGLLLRSNDRIQKQEAEIKELKQKLEQLGNAEIIEQKDEEIKNLGVQIFELETKMKNMETEQQKALKQKEETIVFFQNQVVEMLKKMPKQAAYTRKKSTEPGEEGTMTLDGEAPEEEATGLWGLVSRASPGLLGGRQTVDRRKMKDVPPSPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJT8</accession>
    <name>A0AAD2JJT8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001946">
        <property type="protein sequence ID" value="CAJ1957447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="817" mass="90832" checksum="61D7F6B4FBAB839E" modified="2024-05-29" version="1">MPVFKEGDEVTYRKSTAHVGTVLEVKTDGDVLVKWENNDTWQEASDLHIVHNDPLSTPALSFRRKRRRITPPAVESHTNATGAGGSNHDETSNPPVTNISFTAGDSSPHLSSRRLLPEGYMPKVRHALASSSSSSSSSSGALATQLDVSSSSSTGSSSTSLVSSSDSSGSKSTAMAPAAGSYVPRRRSEFDSSSSSDDSSDPHSSPAQTATSPDGNDRPENDAEGMGAINDPDLQRLREQYKEKIRMFERLDLKGYLDAFEGPSKDALQYGYDADSMNLATQNLPDIGFLRQSGFHFKKASANNKPYRARGGVRKSRKSRTGGLRPSKGDVVMKGPTPLDQFPSFTIGKIYFNGISMYLSVHVLMETGVGQSCHQDIINTWNAVNRWAYGCSKRSILHLHRNKKLGLDFGDDDMNSTVNLYRLVASGSYGFGEAGEKDPGIESISASVTSLHLALVWFLLGAIADAEFELEETDEDSAHALYYCSVFLLQGAGFKHKWRERFGDKDSVQRKCDFCPIQQRVECNDWVQGKVVETHELAKRRFFRQDVSYHASTRCAIDIAVTIHCKGDWHVLPCGKLAKLTIAEAVKTRASEAQQIFDEVDDEDEYGDEEDDDYDDYDDGDDGDDGDDGGDGGDDDDDNLEHIDYWEDVDHTKDDHDGFCDLALLERVALLEGRIQFPKFGTTGEFGCCQIKRDTLAMNATSTDTYQPDEDDDHQRVDIDYAARNPRAATIIQFYLPYYRFAFRDQVKKKKFWEEARELPRVIVRMASKFESCLIENKALEAERKHFYGDASEYNAVDQSIFRYVKNRFGADVGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK10</accession>
    <name>A0AAD2JK10_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK10"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="542" mass="60259" checksum="F819696EDAAA1D4B" modified="2024-05-29" version="1">MPSYHYFGKEGEAIPEDVEELVIHPLVEEIPRTACCKFEHLTRVHFNGSALEVIGSAAFYDCTRLLEIEIPASVKIVLDSAFSSCKSLTKVRFHEDDGLLTTIGGSAFAYCSSLAEVRFPSSLMTIHKDAFHECRLLTRVFFQEGLKTIASSAFGRCVNLETVDTPKSLEMLGGGAFQYCASLQDVTIKEGALRVIERGAFRNCNEVQNGLKYVGEKVFYLCKKLQAVALPGSLELIGGSAFEGCPKLVSVELGDGPSTVTIHDEAFLECRSLVNICLPSSASIPTATTTEAVSDSFEGCTSLKSLYDDTNTMLALRHRFKNFPIHKKCYYASITTTGELTREIELSMQSSQDTTGDDLLIDPFGMTPFHVLLSAAYFRLDLLQVLLDAYPANVLRWKDLNGKTAVEYYYQRGYHLSEDSQTILQAALHRWMVGSIRSWDGLEAWTANMSSRVDAIVAEHVVERRRYLLREASMALSRYEEVEATSLLELSLWENEMKSAIDASAENGARVTVYKDERVAYRIRSGASVVIPNVIAFLFSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK53</accession>
    <name>A0AAD2JK53_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Silicon transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK53"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015708">
        <property type="term" value="P:silicic acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004693">
        <property type="entry name" value="Silicon_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03842">
        <property type="entry name" value="Silic_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60372" checksum="1E0CDB7102991AFD" modified="2024-05-29" version="1">MLSNSPLDLFKQFYSTCLVIFSVVIVTALMFTENTKVANDAHPVVALVVMWLGILWMSMVEGGQCSMVGLPPIDRELYKDSHKITYQICSLGHKGDNLDRYLMGRQFMVIFINFTISLCGSPLEGASVLGLPQWVSDIFLGSGIAMVLTNVNIGQLTAQVNASHCMLDYINTHFMTFTLYCTLLIEMTGFMHVCYLIRDCFYFAAGKPIVTNEPPRSAAKAFFHWGRVLFSTVVLCFSLAVTLEALFKGQTTMWDFIPNWAAVIIFFVLLSLVGLLEAMQIAFFAVSKFKKEDRGDHPMARRTCNLLFKGEGRNLPGFMVGRQVTVTLIFFVAARVTTLNIKIGEDENIFGVSDGLQEFFNLGFLGAIITTILASISWQLVASAFPIAFLSNPFVYIMLNVVLAIEATGICAASWFFGTIHKKIAGFQLDEVYVGTAEEREAGGKPDTSMHPGRDFSIGTVLVAPKNWEEAIKNLESVPETFSQRRERILSNIKKMKDMMADASEEEKGAYAAGIQAEVKYLEQLNEEEESEASPAPVKDIEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKG7</accession>
    <name>A0AAD2JKG7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47580">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47580:SF1">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="477" mass="51803" checksum="B4E8CC7174F5DCBE" modified="2024-05-29" version="1">MAAGQNLLEEEDIISTNPLFLTNREAALSPKGIAQVQEACLFLEQNQINPSVIKYSLAASSMDTTAIVKDALRVGQNRLIPEFTFMDPRGIGKWDTMSYSQTLPAIFALDETEAGKDGKQGRPPPNDDGTPNETLAEQKIRLVQLISVLETQFQGDTVLLIFPDGSTPALLSCMMAGIPFNKVHELEFAPGEVRLHQDMANIQTLYETRQQQSALNREYEKTVQLGKVELERLRGLDPATIVSKKDLKLQKEVAEVEEQQRQRDEQRRIKAEKEEEARILRYKTIEEARAKKEQAAALQRMSQSGGASEGGDKSTQIAIGSVTSLAVVAGLAIGGQSDTDPVAAVSSGSAAMRNETFAGPLNATTTTTTSGVQSATRAAATANAPTRASNATTRVQSLPDTLPQTILPVGDAAASNKKSLYSDPVPTKENKEEAAAKAMEDYMNQDDGGDDWLTVMGQLMEEDETGEDGQDIIDEWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL84</accession>
    <name>A0AAD2JL84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF281">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="4">
        <location>
            <begin position="325"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1959359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="507" mass="58789" checksum="645BC40A39CD5ABB" modified="2024-05-29" version="1">MAPFRKAKESNSCKSRGPNGRQRTFNLCCYIVACLTLVIGIKFFQPQTSLWVDFDSESSSASSIRHEQTKPKSKSCSEEKERSPSTSPELLLSVPFYVYEDQAWINATIQDKLVSDMAKQHTKYGSRFKHGDDYWLLEASLKHPMRTQNKSEAKLFFVPWLLNFFDFRSFKDVPLCWNGKCNMELLLDAVAALKESETFKLYPDRHIVVRSFYSAHWESWNQELERGNKEGYKQFLYVFKKMQVITFEGKDLYPNPGHRIVLPSYYVGTPCKLSNEKPFDVAMVASLSPEKPRFQHRRNLCHWLKNGQNHENKTTLDLKISSCGHAEQCPALAESKFGFHVAGDTFSSNRLMDTILSGSVPIFTHLNQYTMAGGEWIDWNQLSYYIPIHNDTNLKSSPEDAGKLRPRKGANQNIATHPTSRYSMLPPASESTVLERMDAIVHDEKGYEERYHKILQHIPLFEYTTLHPFDTYMYLFQAELYPETRHRPEVYNCRWSALKLPRPFFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLA3</accession>
    <name>A0AAD2JLA3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-dehydropantoate 2-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS18953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLA3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF26">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="4">
        <location>
            <begin position="47"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="5">
        <location>
            <begin position="246"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1960927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42362" checksum="B058DE89B11A0ECD" modified="2024-05-29" version="1">MRASYFRISKTLTVCVCQFIRPTAAFQSALYSSDAGRIFEAESKPSVAVVGVGAVGGYYGARLWDCGAYDVKFHMRGDNFSQCKKNGLDVKSVHGDIHIPSDQLQAYTDTSEIGKVDWVVVALKSTSLNAIPSLVSPLLDPERTRIIVIMNGLIENDLIKMLKEFHGENVDDEELNFCKALYGGMALLCSNRVAPGSIEHSFASLLSYGVAAHSADTTVKESLDNCQEFWKPVKNVETRLELSLLGGRWRKNVWNLPFNGISVAMGGITVDKVVEDEGLRKLAYEVMDETIAIANAELEKHGYDSSLFLGDEDKEKMFDLSDNMGPYKTSTMIDLTERRPMEVQYLFQEPLKRARSLGVDVPHLETIVAQICALQKWHGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLU9</accession>
    <name>A0AAD2JLU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042123535" description="VWFD domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="697"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1962721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1418" mass="153769" checksum="EA0938C7AB97916D" modified="2024-05-29" version="1">MMKPSVLLATFVWMNSVVATVQADTFTIQMTSGFSSRGVRILTRPLSGYVADVDNPMAWNMATADLYCPIFDPNVIPVPPIDQPENWGRKGFLSGFKIIPEQQGLTLTSVVNVDYVSDGQPFTATSDPRSSVPLPNGVEMNSYMVQALNIHDSGGTFSTSRYFVDFPNQEIVGVAYSDHIRISNPVFGLNGGNAYSGQSTTNGLTLSVNEWFKVNVDSVPTDSCPEAQPRISSAVGANGQTVTLSIAAEFNLRQARIITKPRPGYSAATDIPKVWSLSAPGICPIFETDALLSTPMLNKFNIGRKDYLDGFKIWPEAQDVTISSDVYIDMWHDSDRCHVIKYQDSTKFALPYGETYNAYMAQAFPASNEYSVYQNIVQFPNQDVIGIVFTTDTSKTLSLLRPTDSVFEVGTLYEGNNQFEPGFSPTNIGMVLGGDAWFKINCDEAPDEDTSCVESQVPPPLTRVGERVSVKMAVGTGPKQVRILTRRKPGFLAPIPPPIALNNSSGTMTVDPNAFVAPPAECCARAELDGFFVWPEKQDFSIPFDGVYADILSTNDRCIYRTNDDETRYEIAQGVGYSSYMIQGYATVSTDYSYSVEFPNQEVVGVFYTTPDNTQDLLVVYDDFFNDAMNTYDFSFRSSSSRGIDLPGGDWITINCDGPPPSPVAPRGSYTVDRGFIGTVVDLSVQSRNPDDPCEMCVARGWGDPHIETFDGVKYDVHVQGELTFLKSLQNDFEIQARTEIVGPGQSPAITTAVVVHENSIHNLPVVQLSIAQPNSIQDSVEIATCPVQLFVDNQYKNIMDGTGTEDASVQVSGHNVYVEYPLTRLRLEVRVRLWKNHCLFDVNYLLADCRCNDTLVGILGSPNGQWIDDWMDTNGTAVAIPRNETDRRLGKAYNYSQGWCLEDAGDSHFTYDGDYDFKFFDNCTLPYDNTIEDALDDATPEEIAACTPEGEDMPLVGCLIEAVTFGLEAVEVYLEKEKGDDVISDYANEPTSGPTTGPTSVLTSHPTSGPSSAPTFRPTSEPTSEPTSGPTSVPTTGPTSGPTSGPTSPPTSGPTSGPTFPPAYGPTSGPTSGPTSGPTSGPTSGPTTGPTSGPTSGPTSPPTSGPTSGPTSPPTSGPTSQPTSVPTAGPTSGPTSGPTSGPTSGPTSGPTSGPTSSPVAKDDKPETEVNGDPHFKTWKNEHFEFHGQCDIVMISDKDFSNGLGIDIHIRTKIVRFWSYIEKAVVRIGNDILEIEGLPDFSASYWINYEHMGELTDLSGFPVSLNHNSDRYTIDLGSLYPGEEIQIKTFKEFVGVKIIGASETSFGKSIGITGDFRTGNTYARDGSTVLHDFTELGNEWQVLPSDGHFFHAASRPQFPEKCLVPENPQGRRKRRLDENTVSEVQAGAACARLEDEFSRKGCVYDILATQDLDMVGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNJ9</accession>
    <name>A0AAD2JNJ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002300">
        <property type="protein sequence ID" value="CAJ1966549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="242" mass="25989" checksum="D9C19BEE9DF35F0F" modified="2024-05-29" version="1">MKLEVQTSYDSIDQSVDGPEDYHPPLSPASGAESLFLAGLTTSFSPDDLSKQLRKNQSASSSVSLNTTATDDFMTAAGTVDDLFMDLPRERFPIPEMDDEDEDMAKKKSNKTTMPPKEPLTTTTTESHPDAAANVYEGAKGVWAWGKGVAVVSPFMGMAEAVAGKALEVAGTNMEALDSNIKPQLKNFDSGILNPAIEKVTEVMLGAAGKAEEIIKPIFVLILSPFKMLEQQPSSETPEVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNS1</accession>
    <name>A0AAD2JNS1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002341">
        <property type="protein sequence ID" value="CAJ1967711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNS1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAG-pre-integrase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="143" mass="16505" checksum="27E5F5F7262B2A17" modified="2024-05-29" version="1">MTHLSCNEARLQPTPTLFRESLIDPATIPVAGPPVTDSTECDKQLPLPTLIDSDLHFDLEEATAADHITNLSDLTETDKHTIMLRWHYRLGHTPFPQLKQMAKYDLLDKRLATIQEFPFCPGCQFGKQTRRAWRHRSNKKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUS0</accession>
    <name>A0AAD2PUS0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS13428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1952194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="445" mass="49955" checksum="3465FB708088D2A7" modified="2024-05-29" version="1">MNLALAKTSKFTVQIGVIVAPRTRCLSSLTPVVKDTYYVPRADRGGPNDSFVFNKLGDGRLARQSRHSPTRELNFTPTHWERQKSVWLRFRAVRTIFHSSPFQRLMFPDLFTVGATASAVAVYNTQVAENYMEQLTLHGSALSGATTALGMLVAFRLNASYGRYDEGRKFWGEINNAARDLAGNACMWIDDPYQKDRMLKLIKAFPVITHFHLNAKGGHFMYADDDPDLGNKLYAELHAELLDIYKDEEHEDFKYICSGYLDKIHLPLHVSAGMRRIIADNGAYVNAFYNKTMDEQVRRIVMCLGQAERVLRTPLPTDFTRHTSRLLALWCFLLPFAIYDGCGPLGVVPASMMISYAILGIEDVGLQIEEPFNILPIRQYSDGINAGVDAIANGYDLLDNNPLKRIAAAEETTTPEEPVMEDSTKFGSDEATEFEEDSEPRAATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUV5</accession>
    <name>A0AAD2PUV5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUV5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042055123" description="PSI domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24287" checksum="674E75273E52E004" modified="2024-05-29" version="1">MMNRKLHYWSLFCLLLSLNNTVAFEFSNLLYSLKLCRGPGPFCPEPDCAKESKQHLCQWYDCSSTASRRSLKSSNSSCTFFGSLSSCGNDTKCLEACKKLNDGSCPLCISGYEEDECQDTVVYSAALVNSTDATTGTTFSGISVSSDITFYHGLLAFLLGAGLLAVVLSRGRKKSLDDDLTFAREGLVKGRMDAVEAGNASDISTVENRTQFRQTKLPYSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWH1</accession>
    <name>A0AAD2PWH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS18497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF4">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="155"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1960082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="827" mass="90647" checksum="385326BB80A75BCE" modified="2024-05-29" version="1">MSSQRVLNSSFRALAVGGSMSMGSWLYQENIGTSSENRNTSPDPNRSADVFAPANVMCSEASDMMIQESLFSLLPRPKITMMDGAAYSNAADRDKTAKPTRTITYDFVIIGSGSAGQSALKTLKEKCPSARIAVIDPVRLANGKEGRSVDHYKETATGFNPKLKTVQFMDGTSTQLKYRHGILLATGSRGAPPPLELFQLSALPRVFELKTTELPGNSMKRPVLAPEHVRRAILGSAAKGAKVAILGSGWDALDLASVISKQGRRKPTMVFGSQGPAWNILPQYLSSELRKRLVKRGVDIQDRSIVRYIADIDHFKTKKIEMHTAKSFDLLDTQRTVLDMVVLAPDSFGNKGTAALPTRQIPEKMIESGDGRPWYKTWAQLTKTDDLEPSMIACFEDDGRVVVNSELCAASRVYAAGSVAKYPNSATGSSAIAGEGILDGTKAGEVAAINMSKDFSRDYGYGRQDDDINSFAAISLPVWRSDLTSYQGMGSVTPSSLGSLGIRALCVGNCDSEKHGTRSFWWTNSSAYRKLNRAFEDDYDVGYDDESTNEEAAEKLKTMRRLSMRRLSKRKRKAGAGKPLYGTGVVFYLTKNGRIRGIMTWGLPFTSGETSEINPVLLKRLKVILASNAGVSSLDAEENHQEMNTALARASQDLVSIAFRDQATDITQETHGLNGPISGYSTPLYRYTEILPATSSNLSVLKRKEGGALGVMGEDLFALDVMRLEEPETAIDENDVAPSNIPVTVYPVTVVPFQVEEAYGSEAASLSSLKELNKYLAVQRGWEENEERARPGKEDLLWLRPGDERKSSSKKQMIIDAYRSIMFAHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXI7</accession>
    <name>A0AAD2PXI7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS21701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXI7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="77"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1966118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="314" mass="34692" checksum="900FF7F51BA78456" modified="2024-05-29" version="1">MSDDGNGSLQAAGSEQSCQSQSGSFLSPEEKLDTQVTCDVLCSLSASYPQRSAAAEETSSEIGGEKRKAKTCPKQHQLPLFLSKTYHMIDRCDPEIATWSASGDNFVVKNVEKFASSVLPLYFKHSNFSSFARQLNFYGFRKLRTDPILTSDVDPRTACYVRFYHDKFQKDRPELLHQIKRATKSDQQNKDEVESLKGEVSQLKECIGQMNHRINTLTSEYEKVAALLTEFLTRSHQQQMKQQTTQQLGPAAAPQAVATRGPCNAPDLMHSLSQVAAASLQSHLQASVPSSNGGSKRDNSEPALGPSPSRQRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXS5</accession>
    <name>A0AAD2PXS5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS22914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1967745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="964" mass="104536" checksum="D8FB67F17092C22C" modified="2024-05-29" version="1">MPEYSSRRHKTSRSTGRSSCQSKAQEADEEPSESSNASNLERGERGKGSHVRSTQTSRSPNKKDSERSDRRSSRRPKPREADEEPSESSYSEKTPGNARELRSEPKHRSPKKEVSLLGDRRKEQSVARTSKPGAFPALNKTSNPGDRRKRQSATRSSKPASTLENGTSSSSDHGKEQSIARASKPGAITPQNDGDREKERRSTRSSNPGAVHDDRVSNRNRRKQERASSSSNQTRSTSGVCDFSEAATVEHDPEGDQVLLMRREIEQLNQRLGAERGEREANEEAQQEAQLKEKRKRRNRIIIVLLCVVVLIAAGAGAFFSFTKDETTGDSATANGNTEDPTTTPSSVTINGNLSASVAPTSAGSNSPTVTQLYDPPNEDICLAISRNETIAGQVDLDQREFDMAFDVTLEIDDDITVPEIQTLLDAIQARLLPPLAGCSSSQTVNRRGLLTANDQQTIRAVVAEPHSRQRQLAIGNSRFVIFNAFVTGREDPDVVCITTQDLNLCHRIVVTVSAILKGPVQLTDIVVLTSEQVSDKLKEQEQVDGNLKDPLGLGDPFSEVQLIKFDNANESATPSLSAFPSVGPSDTSSLRPSSFPSLPPTLAPVVGPTLSPSSASSTVPSRVPSLSPTATASEVPSASPSMVPSMAPSSNPSIQPSKAPSPNPSIKPSMVPSGSPSVQPSLFASDTPSLKPSVVPSFAPSMNPSQPCFESDGELVSEVENWFGTELQKTSAENTYGPIGGWCFGPGVTSMEFLFANKYTFNEDISNWDVSSVTAMKSMFYFASSFNQDLSSWDVSSVTDMGRMFRNATAFNGDMSSWDVSSVARMNGMFRDAPSFNQELSSWDVSDVTTMLHMFNSASSFNQDLSSWDVSSVTNMNYMFSQASSFNQDLSSWKVVSVTKMTAMFEQASSFNQNLCAWVSRLPSYANVDFAFYGAASCQSESNPNLFATTTGLPVGPLCHFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCD8</accession>
    <name>A0AAD2CCD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000025">
        <property type="protein sequence ID" value="CAJ1927733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF6">
        <property type="entry name" value="CS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="126"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1927733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="230" mass="25742" checksum="FB4F83F13A48FAA2" modified="2024-05-29" version="1">MNAAYTERENKNQHICLENEKNSMVISSATRQQTQQNTPKLAPQPPHSTVKMTTESPVVDNENAKSALQENIESKGKNAYYFAHAHKANGPKWDGKAEPKLLSMEKLSVDEKTLKKSHTSFDYHKSNITAYAFADGTKSVKLYIELDGVGEKCTDEDVTLDSTESSFTLVVKNLKEEDQVLSFGKLTANIMSASYKKQENRIVVTLKKEKEGEWHTVNDKGAPDTDNEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD47</accession>
    <name>A0AAD2CD47_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000045">
        <property type="protein sequence ID" value="CAJ1928447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD47"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="377" mass="43235" checksum="13D5E0CD2AE5553C" modified="2024-05-29" version="1">MDDADIDGLQYPVSQPHDANGDPQPDVLWDVPKPLKAYLHGIRGYVYHRETVLKDPVTLTNCVLIDPDDFDTYRASSAFIVFRSRTIPQPLVSKPSRQSPAEEFDRGIKLDAILYPTLSGDDKQWDSYRRNLEATCRTHGLKQVLDPKYQPTSLDERDLFDRHQSFLYQVFVRTLLTDQGKKIVRQYDKTYDAQSIYRDLCKFYTQSIKATSTANTKLQWLTTAQLTADQWPGSHVSFILHWLDTLRQYHEVAKHPTPEEQLIVMLSNAVRLVPYLRNVFDTSEQLALQNNNRPLTFDEYASLLEAAAQNHDEVTKGSKPKPNPRKAYATDVVTTGDLEPDPCPPMFDFNIDMDLGDYYAYRTSLSSACKTFLPNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD79</accession>
    <name>A0AAD2CD79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1921750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD79"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050962">
        <property type="entry name" value="Phosphate-bind_PstS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42996">
        <property type="entry name" value="PHOSPHATE-BINDING PROTEIN PSTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42996:SF1">
        <property type="entry name" value="PHOSPHATE-BINDING PROTEIN PSTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042182770" description="PBP domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PBP" evidence="5">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1921750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="503" mass="54330" checksum="663AD8B6F6DFC18F" modified="2024-05-29" version="1">MKFSLSLLLAAAIPASDAQEVIPLHGSGTTNPQKCYWDIMDTLMKQSKLPIRMTYRGVGSSTGQADFMGDATTMLPFNDFGSGDIPFSQEDFNKFDPGTILHLPVLMGAISFFHSVPTGDAELKLNPCLLARIFSRDITTWDHPEIMAINQGLELPAGYPIKVARRVLGSSSTKSITTYLHQTCDTEWPIEMVDSVVNWDNDTLPCEGSGGMTDCIRANPGTIGYIDSGHGHLENLQEIDLLNFDGQYISSKVANSRGGILAAAESPNAGLPNELDQSFANVNLLNQPGGDTWPIVAMSYIYVHKDLTRHLTPESAQLLKAFLTAVYTPEYNAICEQSFGFVPVTGTLREKALQQIANLNTGGGIEWFFEFSTDKTGTGIGQGSHTFSVKRDSYSELEQDSLISQIAALQAEIAEMKAMTGDGHTHDGDDDTNTNGGSTTNGGSTTNGGSTTNANREADAGDDEDMEFERDDELTAALAMGAISIALWAIALVFVIVKYVLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE67</accession>
    <name>A0AAD2CE67_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000180">
        <property type="protein sequence ID" value="CAJ1931770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE67"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="717" mass="81081" checksum="4962503C3267473F" modified="2024-05-29" version="1">MPHEDRKKAGLDAFLANDGPRSVLIDADAPAVHTVSTVSQSTSPKSLSEELASMQNETTPIREFEKKEVNNILRINVQSTKQVYTFSIPVSKMLQREREMRVASKKARVPEAQWSCSRLYSLWKEARSKEDEDIASRRPSSQITVDLEPEKSMRDYSKFVWEPWLTTCLKGFYETGSIEIPERCQGPDLLITLEYLRIITVSPNVFIFSSKEPYDRIRSWSAYFTKRRTILDWLIKDYTNNGVAIRTYTTSTDSKEGSHVLLQVKGGEVDILGRNRHDSRLLFKVVYSLFCENDSEQMLTKEVPKRIRHDFRDQLLRFLPPKTRVSFELHRVTVTKSGLSVKEVRPVLRIEGPFVDKPKNRSPLAERPSHQTDISDRVSTDDKNDSAKYQSDAGARLGIAATGESTRYRTEDNPRAIAARKEATKYQRKSSAKVGVATTKESVEKGQNTKLHTIAKKQVFEEKKIEKPDIPRPPSGPSPMPVVQMQKQGSITSGLSQSLLDESTMGTILKHPPSDTANHSPQRSRFEQSRSATANRQQDSSAHGDQRPSRAYVRKYEDYDDDTKTFTDSTLSTTTYENRRPKRLEDSPCDTFESFLFHVCDSGVTVCDHMLPAGALTHPCDDRIGRDSDIDEMNGNTAIVTYLPDESGNEYSDHQNMNGESAENEGVIAALSQDLTKMENVMHAAKVFGDTISQQMDDLAYRVLDPENAEVQISKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEM2</accession>
    <name>A0AAD2CEM2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000080">
        <property type="protein sequence ID" value="CAJ1929426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEM2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="79392" checksum="38477459F43D6C47" modified="2024-05-29" version="1">MLLHSTASQHSFTINHNGNNERRIETPNDKSLGETDLKEDINGSDWNKIMPTAKSPSNEEIETNATDIEHVMDATTPSISINNSKVCLLEPLSDECLKTPNIFQKISYEISDHNEDDGGDDDDECDIPELVEEDDSILASIRLDILHPEPASVSAVSEVPTSISSATSPQTLFATQQPFGTSRPTNSILKTSITTSGFKNKKNNGPTPRRIRGMWDVNIIISGDSESDTADNKTMKKKKTPNVFSQLRDETIIHCLSFLAGEPIDLLAVSQVGRRFHSLVTTSLSLWRTVDATNFVHQQFNQHSNSGEATTKTLAKLLLKYPPETLIIRDIGDKLHADESFLPPAGRLKNLTLTHFEDLTDTHVHVLLLLLALPVKQYQKKKLVQASSSSLQQLSLEYCPKLTNATVRSIASSPSCVELQSLSIRGNSGISDLLPIAKLLQIKPGTTVPTLRPRKPSLPNPLASLFGGPPAPSTPKPPRHSPPAGLNSLFAPPPPKPGPPAGLNSLFAPPPPKPAPSAAGLNSLFAPPPPKLPVSTMELHKTAAHSVTASPPRTSALHSLFAPPGSSPQRNQSLTTTPTATTNTNTMSLPKTTIIKRGISNSTSHATIPSLGRNTSKSSTRALCTIDIRSTGIKPQSWLQCCQETTTSSSCKLWLQSFAMDGDSWTDQLLKDWADLVSLRDLKVLNLATAIANGGVGNGGITDTKVLEGATWLQSLNLNGHNVSDTTTTTIDQSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEY0</accession>
    <name>A0AAD2CEY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000091">
        <property type="protein sequence ID" value="CAJ1929717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEY0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="17461" checksum="A53F43AB6CC4D327" modified="2024-05-29" version="1">MRGVQLSRHGFSGAQVRHGFDATQAPTPQAVKTGYFDMSNVFHDVIKGKDENGNDVYLIPCPAVMTNVKLQADWHYASEDEDLPDLATEQIEVCSLFKATERKEIHLGCTIMSSWKVVVQTPPFVMVSLCMDSVMLIKNLTCTLTWVAEFSTKKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGA2</accession>
    <name>A0AAD2CGA2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000184">
        <property type="protein sequence ID" value="CAJ1931856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGA2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="92579" checksum="990C4E4440A1E02E" modified="2024-05-29" version="1" fragment="single">MQLSQQGFCGAQVRQRLDATQARTPQVVKTGYFDMSNVFHDAIKGKDENGNDVYLIPCPTGTTNVELQSNWHYASENEDLPDLATEADRGMQFIQSRRIERDPFGLLDHVIMDSGCTNTTICNGELMHGLRQAEKELDMHTNVGSRVLDEEGFLGRFPPPVYYDEDGIANVLAMREMIAAGYRITMDTDFDNAFVVHCDGDRQMRFVNCKGVYVLEQLGADVEPGSKEISAMYRRQLSSVNKQPNFELSSKQNRYAGLGMTAKMATVRKNKEGFIPRQVKAAMEARSAMHILNAPSTKSLKYAIRFGLIKDCPIIEEAINHAKAIFGPDASTLKGKSTRPTPKKTHDDFFSPPEELYQHNRSIIVCIDHMEIRDAKFLNCIDTTVRYRSCIPMQNLKTDPVFEALDKIFRRYNKAGFYVKTIKCDWAFIPLTDDMLDDMGVTIDSTAAGDHDPTAERNNRTLKERVRVALARLPYKVVPKVITECLGRRAAELLNVFPQKDSISSHFSPQQLIDNVNINYKSDMVAELGQYVHAIGTDSNNSMEPRSIEAIYIEPTKGQRTGHQVLNLNTKKMISRPKVVVLPVTDQVIQRIEAWAAAKGVDDTEQGYLEEAFDQDYEPEDEHEHDFNLRGQFDDIDDSKRNELLADADNDVDDMLELIVRFQGDDDYESDDDDSGGEGDEEEEPIVADLDHYQENVDRGTDDIGSLVTDLEDLQEPPEEEIVFEPETPQVAKVTQSGQTYAQAAMSGLNLSQVPKKPREWPSSRNDSSANKNKNRVATRRKHRERELKPLKDKLKSGIRTKEGSRSTKDSKAILEAQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHV9</accession>
    <name>A0AAD2CHV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHV9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28207" checksum="865CBAE061C0DE00" modified="2024-05-29" version="1">MDDFMKYANFSAPFFGASMWQEAMQNQCLSQLRRYGVKWVLTLDVDEFVEIRGDESSRQEEEYPLRSFLAQYYDQDNNDGDDDDGNIQETKETNDNNKANEKANNKGQKVKPIGALRMRSVPFPTNRKFNLPTFRPPTAWPWIMYIGVHWCRRYSHGAISKSLNAFHEVMLHHIRAATGDEYWLEYKKSGGKGMVKDSTMAEQHRIQVCHDMIMIHGPFAAFVKHLDEAKCNDWPPPKSGMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJP3</accession>
    <name>A0AAD2CJP3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000413">
        <property type="protein sequence ID" value="CAJ1934919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJP3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005049">
        <property type="entry name" value="STL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362:SF0">
        <property type="entry name" value="EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362">
        <property type="entry name" value="GLYCOSYLTRANSFERASE STELLO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13704">
        <property type="entry name" value="Glyco_tranf_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03385">
        <property type="entry name" value="STELLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042152107" evidence="1">
        <location>
            <begin position="23"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="793" mass="90227" checksum="276095D151B22B7C" modified="2024-05-29" version="1">MKYLSILCILAILVWINSRISCEVSRYWLQGRRTTKSRDDDALQFSSGSTGSRFTGEKVRRCDDCGLHGAWSNDSAELFPDQNSSRCLQWAVVTTIFEPNESIFRVSRLKNWCLVIVGDTKTSDSAYYELATKKNIFYLSAAYQKDLMLNRHSFMSMMPFNSFARKNIGYLFAVTQGARVIFDFDDDNVLEPLEDIEVDRPPFLLEYDNGDFEGSKKSVLLRFVPQESKPDMLPFNPYSLMNASHAYSWPRGFPIDEVQASWKGWGEIPTKFGSIKYSSIGVIQSLCNGDPDNDAVFRMTRLDSTKFTFDHSVDSFPLLVPSSAYSPYNAQATTHLYKAFWGLYLPVTVPGRVTDIWRGYITQRIMKEIGLHLIFTPPIVVHKRSPHDYLSDFEAEKDLYTKSSRLLEFLNGWSSETQSLKEMILELWIELFERDYIQLHDVKALTAWLSVLDHANYQFPDRIDSILKVIMMTRNEWPLITNWVAYHGLLLGFENVYIIDGSTNPKCISYLHYARDILGANVIFTDANLNKLSILLTALGKQIAGSSDYVMKMDTDEFLAVYDDGSNSLKTSVSDYLFNFTVHGNDMAGQARVGYLQASLPSKEICQEDINSSPESFPLGPIRFAGDGIYKAVYKSGYLENGTLSINLGGHVSTSNLIGYTKLAIFHFHLRYYETEIMNSMQAVEQHGYIDRNQSEEKQFQQLARLLNCAVENFCDLCGLRTCVPSCHKVLAVARFYACPDDAKTYYNLDKSNLPYVPLHNATTYYLPTLGGVTNLDFLVTLQESIDRYGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CML4</accession>
    <name>A0AAD2CML4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonuclease</fullName>
            <ecNumber evidence="12">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS5292</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="12"/>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CML4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000595">
        <property type="entry name" value="PRK00015.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF23">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042001820" description="Ribonuclease" evidence="13">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-2" evidence="14">
        <location>
            <begin position="67"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1936641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="264" mass="29422" checksum="403B277159EC4C29" modified="2024-05-29" version="1">MLHVTWLLALIVSTSPFGHALHTSGNLSRIRCDTVLYGKYGKGGNNNRRNKGDVLNVEKGLAERGFDAIIGSDETGRGSIAGPVLAASLCIQVDDWNSYTPIAEVGDSKTLDFERRERIFEEVVSQPDLYHFSVAERSNEQIDDSNIVMATMECFAESIEEVVATLPQDCNAYSIVDGKKSPKLSVKVPCRPWVKGDAEVYTISLASILAKVTLDRNSKEWHEKYPEYGFDEHKGYATKEHIEAIHRHGPCPIHRLSFKSLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CML7</accession>
    <name>A0AAD2CML7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CML7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="198"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1939263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="521" mass="57105" checksum="EFD6D53C64C722E9" modified="2024-05-29" version="1">MALKPTTNSQSASCQSRHNGLNTWQGGILLTAECMGTGLLALPHNVKVLGKWFGISFILFNLFINQYAGTILSQSATRVEERQASLHPKKRQQKDNKDVPKDSTNPGDIENERTPLIPVDNNTDKSISSARSTVVSRSNSISSTVVENETEYVWFDVDDTASLRVDKEENKTTDFIGMAASIFRGEHQQHDSPVVGFVMLLYYTNVYLVLGNYILVMSHAVSSVFGGKMCIPIAGLVASTVMFGLAQMRTMDRLGRSTSIVSLLAMFIVIGQCVYFSAAHPASSDDAGHSMDALPVDPTIIDKLSSMGSIGFAVGSQKLLLNIRHDLADRSTAPQSLAMALTAFGAVYVFVSLSAGENPPSFLFDAIPSEGIHRRVAGLCLWIHVAVSYAINSQAICSSMDRLFFKHWDPVRCLHDDRRWMLLSGVTASSAFFVANSIPFFKDLVGLTGALTSVPLTLLLPAVYHRKLLSVPIWKFDTNHLPSFGLMIFSILFMVSALIGSVRSIMLDWENNKVGFFPCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNL3</accession>
    <name>A0AAD2CNL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000975">
        <property type="protein sequence ID" value="CAJ1940897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNL3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1940897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="208" mass="22528" checksum="36225D5792880E01" modified="2024-05-29" version="1">MLDKANQTYAMEFKDYDQRNEYPTTIDQVAKALIKHKPDNRGKGPTTPRHTPRPNTAGGSAPDGVSNAQANAQTTSSRPAFSCWCCGDTGHGVTRCPKRSTRPQAEWSDPGRYSDAPTTTTSRRAGRANLQVPAAASAAQSDAASSVTGMQTTGQHIEAICNELLLTGVEMALLVLLMCPALMWYEADLLLMDDLMVELQNGTLHKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNT8</accession>
    <name>A0AAD2CNT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000136">
        <property type="protein sequence ID" value="CAJ1931233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="489" mass="52291" checksum="A1F3D4F27CC93AD7" modified="2024-05-29" version="1">MIGRPRSLLWTLTLLASSTSPASLFRKQPAGLLLLASAFTTTTTASAIAFKSGISQRQATYFTSARTTLTMAKSSDDAQKKIKNIVVVGGGIQGTSVAYQLAKAAASSASDNDTKITILEAKAVASAASGKGGGFMARSWGDGSPTQGLHELAFDMYEELAAELKCESYRKLPVISVSPGRGSQSFQSNDPIVPNWLDGNVARISPMGYGEDTAQITPKEFVEQMLQHAPGIRVVLGKCTGVETAGDEGEEQITGVKYMNSSRDSDEEKTLPADVVVVSAGPWSCQAEDWFPNAGLELPMEGIKSTSIVWNKPEDRDVDATALFCGENSNFGTHLEVYPRPDGSIYICGIGGSDYISTAQLKEGAFLENCEANPTRVEAAQASFRDMAPQYKEENGGSLEKSQACMRPCPPDAMPYMGAVPGYTGAYLNAGHNCWGIAWAPASGKAMAELIWEGSCSSINLKPFDPVRFTPKLAQRGRKRRGTNVGEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPS7</accession>
    <name>A0AAD2CPS7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPS7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="271" mass="31063" checksum="D0F18E754EACF010" modified="2024-05-29" version="1">MTPGIVFIPSSSTLVQGINRGGALLFRESSAVPATAPSRSLLVELYKRWFQISSLIRFSVSGNIGVVCFYIIERMLYAQLCQIDGLPDILEEYKDSVSYFFGYLLQIFTQHLLNATLVYGLDTIDTREKYLKTLIGQFSVYGFSLFGSTILNLALLRYGIDRNTSFFTTMILFAIVNYFLIQWVVQRATAAAYEKDMAARKKGYTLLPNNNNKNARNKRTVLQRVSRGGATESRSWFGRIFRRQRREYNSGEEVDRDEVNESCVAFVRQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQB0</accession>
    <name>A0AAD2CQB0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="271" mass="29934" checksum="2D9D8479C8AC3DF3" modified="2024-05-29" version="1">MEDINLGIIAAGLAGLATVLYYFFYNKVTPSEATGKDATSKSQSNESKSTSTTLKNVWDVSKNSKTSHTKQHHDDKPFGSKYYYAHNNPNATGGYKDGLKMEDYVMNGPRLLSKGGKTVESSGSSNLEDDSGEEAEPTETEIEVKPEISTSLRPTRTITKYLWDDPGNSNGIATIRIDTLPDKHGKSVDWKDVTVTNITAELAGEGMLLKVESKECDYQLKIPKLYGDASEVKAVSKAKRLLVKITKKKNAVLVKRKESNMDAWPQPHRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQS1</accession>
    <name>A0AAD2CQS1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQS1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="203" mass="23682" checksum="FAA64A0A1E0C8ADA" modified="2024-05-29" version="1">MTIKATRSESSLRSMRLKKLERRDQQFAVPGSKSKGRFLRNMLEAPKKEPSGEGTFMKEKYPSASIQRPRVVEYYKLNDLAGDESIRLPPRLPITQSGGARKDPRFTSSFSSLDDDQKVEELESYADEVRWFIAKVSKEVEFEDEVYPLHVAMYRIFMVLQEDPTYQYEKLPQNDRKLLFDCCVESFMQQQQEYAEQTNLPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQU9</accession>
    <name>A0AAD2CQU9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="220" mass="25123" checksum="91689A2250D20E8C" modified="2024-05-29" version="1">MCSEYTEYSGNLNDECTYDDYASSFEETTRTTHVHFSEQVKCKATISRSEITADEAIASWYTHQERAKLMVKYIKTVERRQSGKKPKKNSSYRGLETFDQCDALELQYTIEACVDAVLLEQHRQWTENIVDWEALARVSIECSEQSKALALAMAKSDKREAKKANRRMALMVEESMRSISSTSIESFQDMKKLVPHKASQQTALVMGSTISPVIELRSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR27</accession>
    <name>A0AAD2CR27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31881" checksum="AFEBAF080D5CC84D" modified="2024-05-29" version="1">MVASTENVDTMPASPEDHMFRLTKESSTSVAAAFKNDGFVLLQEALDPSLLEDWRNFGEAYFIKSFQLLHENGHTNAPIPYEKEYLMGLGAKNGFKEMVMRSPGRYELSLLDCLDQVPDIKKIVGALEPLLPKCLGGGYKSTLPLKLCHLSILVSTPGSTDQGWHADGGHASLQQHLPCHCANVFVPLHDLPEEMGPTEFRPESHYLTRNLAPMMLAAKCRGTLRVPVWPALNLGDVVCFDYRILHRGRANNSDRNRFVLVLTFAEPWFTDVLNFPKRSMKTPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRL4</accession>
    <name>A0AAD2CRL4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="346" mass="39145" checksum="A36357E5A00C6EAD" modified="2024-05-29" version="1">MSPSENEYEETIANLKQEKEDLEKQVSMLNERNRNQAMLLKRLDSARQTDRTEYEAQILELKEALSQERIKTRRAANFQNGPWSPSASQRSVMAPITSPRQTTQSEGDPRQVSLDDRKSWKDSTGSLTSSGSDRLGNTAQVQSALLGAAMKQKQRKQNKGGFWSLFGNDNHNEDTESESAKRDAAILKNNEESRTSILTKEIMQALEENKRVIVEREEELSAREEVQRVKEEAIRKNQQRRMSEKMSSSFGLLSFGSDNIDEDGDNVRAPTTPDQVNMMNISKLRDSDLLDVDTLRRLIADRTAGMKEEDMTDKTSIVVGREEKEDGSESEYDPEGDDELTAAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSW4</accession>
    <name>A0AAD2CSW4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSW4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="164" mass="19367" checksum="519100DC56A3E87C" modified="2024-05-29" version="1">MELRGPTSKDIKSKVEVLKMELDTIQLELRIKRLDHRYSRLLRKEFPSWEEMTQLLAELRKLTSMKGLDRSGLVLAVQLMKTEAPVEVDDSDETDEEIAELRDRLETLDWEYENLLNQPQHDVNEMESLLQELKILKETKGIEKVPNYQGYFDSIKAKVLRIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTK6</accession>
    <name>A0AAD2CTK6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001424">
        <property type="protein sequence ID" value="CAJ1945437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="291"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="578" mass="64982" checksum="89F4F9C0FB91F3DF" modified="2024-05-29" version="1">MLICTTAVDLDIGELLFSRLKLWVPKNTFDLEVASGVEFEYFAHAVGDGLDASVGEALHSTKLQVTVTEQIFVHDIGESSISWSADDVLNVXXXKKGEKRGGTDRNGQREAAQADTPTVPPQVGFNLPIEETRNRSIQDSEGAPQQSELPDHPSPGTLEQEQAPTGDGQPAPAPAPVAAPPSPRVTPAGDRHQSVRRSTRQRQQPERLIEVMTAELADLDVPFELFAMEAMFPNPVEPDDILAIKASTDPDTMYLHQAMKQPDWKEFQKAMMKEMSDQIDQKVIELIPKKDLPKGATLLPAVWQMKRKRDIKTGKVKKWKARLNIDGSRMVKHRDYDLTYAPVASWGIIKLLLALALTLGWHTVQLDYVLAFTQAPVERELYMQIPKGIDLDGANPADYCFKVRRNTYGQKQAGRVWNQFLVKKLRECGFAQSKVDDCVFFKGKMIYVLYTDDSIIAGPDKKEIDEAISLMKEKLDLTVEGDLKDFLGVNIEKKDGGFWLTQPHLINQILETLRLKQKGKPINNSNSRDTPMIHSRILQKEADSPEFDNQFNYRSLIGKIAYLEKGQRQKCRSTAPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTV1</accession>
    <name>A0AAD2CTV1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS8223</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="12">
        <location>
            <begin position="1762"/>
            <end position="2479"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="2682"/>
            <end position="3000"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="13">
        <location>
            <begin position="3130"/>
            <end position="3162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2968"/>
            <end position="3008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2970"/>
            <end position="2984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1942992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="3162" mass="351160" checksum="5E76C9FDA6E53DD6" modified="2024-05-29" version="1">MDQHERYSTEFREDGTSVKSSSPLAMIIQDLRRKNLVTATLNSGPFASHLDSTDPWGSSDALDGEEEQQTAYRNNFQPSRPTAETTQPNPWVATRRNSWIGSRQSPGKISRRRRSNSKILQGGSIRVRRSDVDMQSVSPSQQRLLSWLNSTRLPQRESPQHAEALLQDTPQLRVISPASTDMQGVGAVSQNGFLGMLLPSQQGINGSNSGGSDMNGSTRTEYMKSLARERANKEAATELSSVLWILAHEMSLEEYGIIESEVFTSVFALIHAQEIEKRVAGLAALDAMIDAPSADEEKKAIKFANTLSKGLRSALGDYEFLSAASKALGHMAMRSTNVDFVESEITTALEWLRTERSDRRLAAALSLKQLAIHAPTTLYSKTSQAELGHGGSNDFLEYILLAVHDPQPIVRVCAADALSRYLKILVERQQVSLTSLLWQVHQAVLEGFKNDQSKKNRASISKIEASQHGSLLVVGTMISLAGDFMLPRYDEVCQEIMAFMDHEKALMRLEIIRLIPRLARRCPRVFARRYLEPSLVFLIHCASAPTQPRMGIELRPSAYSAIGGLVLAMVDDETGSVIGGGSLPTIKITNDSETSGGPVVEMHDSGAIYQRVDVIFRLVSDGLNYRSVASPKTTSKMHIAAFHCGADLVEALGSLAEPYITRLINDIFKTGLSNDLIQCLHAIAECLPAQQGTIEDRLLQAVSYRLAGIKSARDVCDPLIPLRTIYSNEPKHGGLPRVSHETQVEGAPRVQVVRINMSTNANVVADLVLSLQTLSSFGDSMGRVTTLGAVVPLLPFVQNVAAKYLSHPSNEVRRAAALTCCLLLVPPQIVSKNRVGQFSGQIIQDILDTILRVAVSDSSPEVRLCAVKALDKRYDPFLCQSRHLQTLFLLLQDEVLATRAAGVRLLGRLAQLNPAPILPFMRKFLLGLIVEIRCGVDTGRGREEATRLLVVFLRSGSVQRLIQPVLPVLVASLPLDGGAPRLASAALEALGELSRAAGASLQPWVKEVVPTILDTLQDQSSASKQRISLRTLAQIAGSTGYVIQPYMDYPKLLLQATDILPGTKRAPWALRREVIRTLGVLGALDPDRYHAVGPKARKGGAVGGAYFVVQDEVEQPTADVDMNGAVAGRSLALRNFGGNSVAVGSVLTKPLPPHVATVRKQDESGRTNVPWSVTESIEGDDNLPAYLSMYEQYAMVAQPVSTLPPARRMTPGDEEFYPTVAIQALMRIFKDPALAVHHGMVMQAIMFIFQSLGLRCVQFLNDVVPHIMLTIRTCGPSNLRESLLKQVATLSGIVKEHLRPYVADVFDIVEQLWESKHLGTIFSLVLHIAVGVPDEFRNFIPRLIRRVLTSLDELQVAEWANNDPRSTHTARLKETERLRLILFSVKRLRGVLGDYVHVLVPALLKLTDSLVRLQSSTSAKNSDWVTETDLTSIAILGLDTISALLECEGTGAGVRPVTLFWGEKSGSDIRSGSLASRVVQPLIRLLKHNQRSHRNVGMAIVETLCVSARQLGTTIWMNLYHDVAKQAINEWHYSTPELDNLSMEDEYHVSTASVNTGGVKLYDAMIQELQHSPNKRSYNSPYVAETFTSIQRIESSMFHAMDPLQQPVFAENPGTPATFDAAADVFENPIPSQPLSIQTNKKKINQLHLQRAWDVSQCASREDWDEWMRRLGIQLLREAPSPSLRAAASLANAYQPLARELFSAGFVCCWKDLSPPYRANLVHCLETAFAADVSPEILQTLLNLAEFMEHDPSGGLPIDIPILAELALKCRAYAKALHYKEREHSMGVTNSCVESLISINRKLGLQDAALGVLKSATMSFEDKRLNSDQVRREISSRLGPDHGRHEMYYGVVWSAEDHSTSNTERLDLAENKELWLAKLGSWSDALEVYEEKLARNPNDFGAVLGCMRCLSATGDWRRVLELAEYNWDILKTDFAGTHTGKKNNIARGQKKAFRMCSEAAWRLGSWDDLEKYSSELVHGRGSSAPPSSAIIYPASGNREGSTPLIDFEGSFFSAVLHVHRQEWTRAAEAIDDARKAMDSRFTALMAESYNRAYSSMVTAQTLAELEEVIEYNKIEKGFNEVHQSHPSNRMDPSQAREKLLSVWRARLAGCRVDADVHSSILAVRSLVLGPTDEVDATLTLSELSRQAQRFRLAERVLLNPLEALEADLDGSVFGFGLRESLGLHTELQEAMSELSVPRIVNDLLTNTSRAFLPEYGMAHNQWSKELVREAGGLDRLKIQHKLYFAYLKHLWLTDRRGEAIDRLGRLCDVVDLVSNCESAGNDYIRASCWLELGEWKVEEKITPGKHIPGPLQVEILCDFKRASMIVGCGYKAWHAWALLNFRLALQMDEREDNTLDGSLHSSDDQDPDAQRKHVVSAIKGFFSAISLGTKRWSASVQQDMLNLLTCLFKYGDQPAIASIIKDGVDTVAIETWLGVLPQLLARIQIKNPAIRSVLHPLLVRLGEKHPQALMYPLSVLLKSPVLERKSAAESLMTSLRSHSSALVEEALMVSSELIRVAILWLETWHEGLEEASRLHFGEGNVAGMLDLLLPLHQHLENGADTQKEIEFVKAFGRDLAQAHSHLKDYVRLVTEGGGTIPGGTSTANARDATSTQVRQNEEAETAMNKAWDIYYTVFRRINKQLPALTKLELSQCSPALSRAQGLELGVPGSYRVDGSYVKIERFIPSVQVITSKQRPRKITLRGSDGKDYVFLLKGHEDLRQDERVMQLFGLVNALLERDRQTKKHDLRIQRYAISPLSHNCGLVGWVPHTDTLHSLIRDYRQSKKTPLNLEHREMTKLAPDYDMLTVMQKVEVFCSALRRTKGGGNDLYEILWLKSTNSEEWLERRTKFTRSLAVMSMVGYILGLGDRHPSNLMLDKRSGRVLHIDFGDCFEVAMNRDKYPEKVPFRLTRMLIKAMEVSGIEGSYRTTCERTMTVLRESRDSLVAMLEAFVHDPLISWRLVDLSTEDIDRQSSVTDTEAPTTRNATRGAKSNLLNNPITEAPDEDGEDADAAVAPNEALDDVDQQMATSFRNPPNESVVDARRARSLQMYANIQEWAANGRNNGKKDQVAASGSVARSRMGRSIRQRELLSILEDGLAHDEVLNEKALTVIRRVQDKLTGTDFPDREDDLGALDVSDQVQRLIVQATSVENLCQLFIGWCAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU09</accession>
    <name>A0AAD2CU09_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS10013</name>
        <name evidence="13" type="ORF">CYCCA115_LOCUS1126</name>
        <name evidence="15" type="ORF">CYCCA115_LOCUS15347</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1925141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU09"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1925141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1945870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1954755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="117" mass="12725" checksum="C90D73ED88EDED7E" modified="2024-05-29" version="1">MAKTPSKKSVKKAAPAKKSGGSKKKRVETYSSYIYKVLKQVHPDTGISKKGMSIMNSFINDIFERIATEAGKLATYNKKATLSSREIQTAVRLMLPGELAKHAVSEGTKAVTKFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYA0</accession>
    <name>A0AAD2CYA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001046">
        <property type="protein sequence ID" value="CAJ1941616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="192" mass="21505" checksum="050AA77436518B59" modified="2024-05-29" version="1">MDILSKTKVHRGVTKNMKAVRFVDPTCRFDSGSSISDSHASIPMKSDELPAAQHHQQKCIESFRDPDLYCVERRSSISEQDILQDIPRRDTAKADGSPVESILKKGKISKYSAARTLFGSDSSLASNPWNISHDSHDLIAPLIPERYISEDVSTDDSLEASIDSSIPTAKQRRESNRDVFLRQFLRIDEVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDE8</accession>
    <name>A0AAD2FDE8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000107">
        <property type="protein sequence ID" value="CAJ1930116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="468" mass="52363" checksum="57DFD9580865ED20" modified="2024-05-29" version="1">MRLLAGVGSSESNQVQTAYNAFHQFASGIWGDITSKVVLLPFADGQFTRQQLWIRNLKEFDKKAKDWAHLKIYLDPNFGNPYILNKPGKTGSKTYKTRMRFGMDTAPPILMQELRSVLSSEPRAGVFPTPIQVSDMVRLGFLPLLPQELAIGPYCKDLMRLCDFQYPIGLMQEWVNNPRFFSAKFTGSSRGLLCWHVFVPKAFAREADLILAANLDLRKPSCAPFQAPTHYTRDWQAAKDELVLGKQCPQLQSLIETMRERTRATRVLTAIYRIPIELPGMLTSAATENFGRLTLLRLLLAVIVTGAQAKKAEDAEPKKPPTKALDVLSDSESSGDDDDDDSPPTFEWTTQKVFGCFHSKTCGGQEKVPPHGTQVSRGRRCLDRPACSDGPLQRQTKPSVRHDLTSRGRWMLFCGGSPALSSPCDERARQPAVLSPVSPWRVVVPQFYSSNQELVSYRPRLPESQASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE15</accession>
    <name>A0AAD2FE15_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000348">
        <property type="protein sequence ID" value="CAJ1934638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE15"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="322" mass="36373" checksum="76BF344F27FAEE02" modified="2024-05-29" version="1" fragment="single">MAAVPPFFTVHDDMVICGIDNVTLFQGRTVAERIAYEIFSDDFTTTMDSTIDELSEEFKTLAGLTIAQGQIRLMPAIKKNIRAFIQWCRDEIRMGRDPTTTPFPVVDAAKLLRRMKTHEQYVYGSKLMSQQALPQDFTNDVQWEDWCPTFENYLRTIPGRDGVPLSYIVRMNDAGMLTLHEDFLETYINMAPHVGEAYVMDNAKVLVLLSKFIVGNTEAEATLQAINIAGNGREAFNALRTHYEGEGILASDIVEAEHTIKELCCVGEKPKMNGSMFERMLKKAYATCDKHEGREVHSDAMKLRSLQNKVTAPFLQLNKTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE30</accession>
    <name>A0AAD2FE30_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS2496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000169">
        <property type="protein sequence ID" value="CAJ1931676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE30"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1931676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="585" mass="64943" checksum="D0DF27A2A4664491" modified="2024-05-29" version="1">MALASFLRPVDSPRATSFAIGNATTCSISGFMTTAAHSGTFYTCMLSYYFLFTARFGLKNSFIARRIEPVMHCIALGYPIVSAIVGAYYDAYADTATYFGCFVNCPPGKNKEDCIATTLGWIFYGWPFLFVLASLIVNNLLIWFLVHGHSVTLRKKSTSRQIHGSSHGSSAVKSSLDVDDSFHIDSMGVENTAHGQETTAPSSSDNAKKENMQTPDAPKDNQLRRLQLVKSQAFLFVGSYALAAMWGGFMAVGEQQAVTEDEELSLLVKMYPIMVLNAVFAPMQGFFNMLVYARPKYLTTRHQFRDQSRWWAMKRAILGGRTSRKPKIPKRSAPDMKEVPKSLSAKDGVKPESEAVQNKTVSLKRDALSTLTASRGDFSDEASYYENLNDEEKDRWGSNRHDTCAPMKQAPRYYSSLQERDSSLGIISEMTETQFDPIIDHSHEMKLEGDHRFRAQQGDSIPAFSRSTPIYSPSTVDSRWSPKSVEQGKLLASVDLMMPQRVSSTSEMHCINDQLAGPSIDTPLQTPMRTSSLVEPKSEIDDDEADVSLQHSPLPPPAPQASVLEGTSSDRTLRPPARRLSPPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEY6</accession>
    <name>A0AAD2FEY6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1896154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEY6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF2">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="844"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1896154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1020" mass="108894" checksum="A7EEAF684C73716A" modified="2024-05-29" version="1">MSSIGSAMSSLDSISEDSTFGVDREDLPPSVPRRRGSSGNQSRVIATASQAVESLDSISEESSPPSLRDENGQMENTPSRPKRSHGSQSRSSSSKSGSKRSSKSTRRSNGSGPQEINEADGNEAQENEIQREATARSSSGRSTKSSSSHRHSGTKSSSGNNESGVMEVSRRSSRSSISSSPRRSISNNSNENNLANEGASSTQENEHTLETSQRSRGSSHSSSYRRSRSDDSDDYEESLAREERSPRRSSRCSSSHRGSQRRLSSRSKSRGSDGALSQEEEKSLESSRRRSSTSSRAESEGQTVAGERRRCSSRHRRGSSSSAPSDSPATSRNSRSIASVSSRNSYSDSTNHLSRSMIDRMGREHESRDSEANGPLEPVLSEDEGSDEEQPGAYRISIHSRSRISSLASSVVSLISGSTIVSGQSFVTNGNETMTESTRSSSSRFSYTRPASTSAMVRAEVAPNRADEIEAARNRGRVEALTEVRNRDTSIVVAVAQPSRSSKEDRKPSRRRRVCMIFAVLLLVIGCPVAYFALPSTNEPQQDNSPAVKDGGSGLIANVTFSPPSSEDCESIANGTAVLNQAEMFTHYVDMQIDLVSAGKEDATMLVAELMKQIQLVILPLLVGCDSYAKTGSIIGNGIVDSNSTTTCISQQNPNCVGVFVTLKLSLRQEDDGTVVVETMSEILMEQDLSKTLGLPSTVQTASVSLIMPKNVTDVPIYQPSSFPSLVIIDDPFTIPAPSDGLAPVPTGQPLISYTPQPTVSPTWKPVAGSSPEPTPEPTSQPTPRPSPEPTPGPTPRPTSSPVVGPTPGPTPVPSLAATPVPSNSPSLGPTPAPTPPPSPGPTRSPTLEPTAEPSTSPSRSPTSEPTKAPSTSPTHEPSEQPSLSPSATPTDLPSSNPTAMASQYYAVCGRNNFCNDINGTSIVLAREATMDLIDRELVVRCCSDVPYANMVERPEGVGCPYITTNVGGSCKRGKTWEDANQICRENNARLCTREEMEFGCGYNTGCNAGDRYLWSSTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF90</accession>
    <name>A0AAD2FF90_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000340">
        <property type="protein sequence ID" value="CAJ1934590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="218" mass="24937" checksum="E66DF7F21EB2485D" modified="2024-05-29" version="1">MPKLKLYKTSVSSKTDKHLYTEEMTLDKPLKIPHANENKFGKSICFKLPNKVLHCPVYPLVRFDDSMEITISTDGKFIEKKLLKHIPKDASELLNGAVGQNDLLFASAEAKIRRMKIEMNEWEKVDADPLLQFGEEMEPFFVDRHGRHQDSYTLDTVEQAVSFCRPVHHHRFEDMQIELPTEATTTAATAAPGFVPQMSPEEWAAMQKVIKMFGQTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG00</accession>
    <name>A0AAD2FG00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS1084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="42"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="231"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1924440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="623" mass="69648" checksum="C63FF587204B9AF7" modified="2024-05-29" version="1">MPGFSYRQPNARTNPTEVRDGSGRTIDDDSSASGNDAVSKTFGRGIVQDFKRTIGTWWFKEMTNFNTKTVAVSFFLFIAVIAPTITFGAVYAKATNNYIGAVELLLATAWCGIFYSLVSGQPMMINGGTGPVLTFQTVCYDIAKNLDVPFLTFNAWIGIWVCIYQVLAAFFDANRLIKKATRFTDETFALLIVSIFLLGAIGNPSSKVGLFHYFGTDHPHHENMIEENGSEYDYMTVALLSLILGLGTAFFAIGLRQIKFSAFCCNDYVRTVITDFAITISVVVMTALRHTVFEDVQVEELKVPDTFATSFSCCTADCTSYWPTECPDQAEAWGRRPWVVDLFDLNDKIYVIFIAAGLGIPAFILTFLDNGITWHIVNHPSNRLSHGDAYNYDTCISAIMVLVNSLLGLPWLVASTVPCIMHITAMQEKNTKGEVKYIQESRLTGLFTHTLVLACIFALSVIRLIPLPVLYGVFLFMGLVALPGQQFWQRFLLFFQQPTKMDKNHYTKNVPVERIHKYTLVQFFFFAVVCVVREIKAISIAFPVMVLLCIPARLYLHPRLFSADELILLDGSPEEIEDWLLKNDPEEMAADKAQKSAQAQHVADNGLALPAQLDSDEDDEQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG30</accession>
    <name>A0AAD2FG30_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000010">
        <property type="protein sequence ID" value="CAJ1926994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG30"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031151">
        <property type="term" value="F:histone H3K79 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOT1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1926994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="430" mass="47692" checksum="BC181D4C477ED799" modified="2024-05-29" version="1">MQEEGSVYHSPQMGGRLIFSADEETSSLGDTLGDTVLSEGEETEEERKLELLDQFAIPVKRLLLQTLCAEGGTIDSNTVLAADCNDGEVHSCFQKQFHALGVHDLEKLLEDPCHVPTGMVLARIAVEQEHQREKQKLKEQRQKERALHTQKTQLMNMRKRLEKEKSPYREIVDTIHTVFGKQGTELAHNGSSTYAEVTKETITGIVDMLKDHHEYKEDDCLFDAGSGIGTMVFRMLVELHCCALGIEYCNHRTFLAAHAAINFFAEYRLDERFNQGTMLALGDLYNLQQIPKQVTTLIMYDEAFPPGLMLHMADLIQAAPPNLQFVVSAKVNRESCYSQLLINAGLTDLGNVKGSKTNNGGATTFTLFKRLEPQMNKDGGSAAPVTTSVSPAPEKEPLHLQIEGELETFTMGGTVSLVVAVAPICFSRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG39</accession>
    <name>A0AAD2FG39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000486">
        <property type="protein sequence ID" value="CAJ1935580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1935580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="481" mass="53845" checksum="4230C0B4998DFB1D" modified="2024-05-29" version="1" fragment="single">MPGRRNQGRGGPGGRGGRSAQQTGRGSHGKKADRPKQYHPHNPDFTREQVTIYLLEAIALKSLDYAQDMIWSVRNMAHVDFEALRGTQTVYKPGKNDSEFFKSSSQAQLDRNWENLNVKIDKREMIYTTNQYTVAAIITKHFITQAMRDKLSNETDWLDLKEDHVMLLKRIKTFMTITDKTEWQHFGLMESLKRFTNCTQKQNESVNDYRRRFEAQADQVFEILGTDVLHVYATKTMGYLDLDDPEADPDNIKVLQAKFKKEVLGTFKASAFFYNCDRSRFQSMLDKANQTYAMEFKEYEQRNEYPTTIDQVAKALIKHKPDNRKKGPTTPRPTPSAPTASSSAPDGVSNAQAAARTTSSRPAFSCWCCGDTGHGVTRCPERSTRPQAEWSDPGRYSDASTTTTTTTTTTTTTTTTTTTRRAGRANLQVPATASAVQSDAASSVTGTQSTGQQHRSNMQRAVVDRSGHSTSGTTDVLGSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH58</accession>
    <name>A0AAD2FH58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS5930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1938012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="6">
        <location>
            <begin position="212"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1938012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="443" mass="48579" checksum="DB302CD3DAB301CA" modified="2024-05-29" version="1">MLSSIQPMKSSMMLATTTRTIIRSSSSSLSTGARRSAACQRNNFHGFTNKSPRNQQQFHQKTARRRRFSATAIEEVAQEPSYDTLKIIAIGQAIPFIGFGFMDNAILIVAGDAIDTYLGVTLGISTLCAAAIGNIISDLAGIGMGTVIEDFCANRLKLPTPDLSTAQRQLRSVRFAGQMGMAVGMTFGCIVGMFPLFFIDDKKVQNLKKKAHLEALFMDVVTEAKTLVGAESTCLYLRVTKDKEKLLEKHAHLPYCPAADGEYLYAMYYVLPKSKKQKSVEKARSSLPLAIDEVDTSRFLPLGKGIVSRAVMTGEAWNIRDVSEEPDFFPEVRSEDVARPLDELRHMVVVPVLDYQGRSIGVIRAMNKIASSSVGAGPPGDGFTSIDVQALKALASHISVSLNSVYQDQDDEEVRLRDSIRILKEQGIQGKQQGSLTKLFPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH93</accession>
    <name>A0AAD2FH93_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000151">
        <property type="protein sequence ID" value="CAJ1931480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="142" mass="15951" checksum="8F390BFF7B7FC4D2" modified="2024-05-29" version="1" fragment="single">VANKLVSEPAFAWWVPYTLRKRDQVLKAVKRRAVKRQKAEKFGIEVPGPGPKGVARAYELVAENGTTHWSDALIKEVKTILPALKILEEDEDVPVGYQLIELMTVFDVKMDLTRKARICARGDQTDPPMSVTYASVVTRESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIG9</accession>
    <name>A0AAD2FIG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="114"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="497" mass="56716" checksum="174EEE7FE9D50F9C" modified="2024-05-29" version="1">MSSPPPREELDRQVSLQSSEEGTEVEYSPSEEYPGKKYPLQLDNFGFILNVDSDGRVCQNIVDGAVRPRATTLAEKQKTIKREKKWDMQLAAWDSTTLKAKQNSKKFIKRLRKGIPESKRGEVWLLLAGGIQKPGYYEDIVKKTTILMLASYREIADSQKMQEASVKTSPTASESSSFLPKEETNPIIEVDTDSEEDFASTRAFRHIQDIIDRDIHRTYPKHKLFYDAQHNTDSTASTSDSDVVRGVADPELAATILSLEVDLEFTASGGAKKRVTNSMNSTLTPGGQAALRRVLRAYSYHDRDVGYCQGMNFIAGMFLTQLSEEEAFWVLVGVMNREPCHMRGLFREGMAITHKVLHVAEQLTYLHLPRLARHFKKEHIHVTMYATQWLLTQYTSSFNFDLVVRVWDSFLGEGWKIIYRVMLALLSQSQQKLLKMGFEDMLAYFRELPGRINANAVMAIASKIPLKTKQIKKFEREWEVVRARKAATEKDQIEENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJN3</accession>
    <name>A0AAD2FJN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000510">
        <property type="protein sequence ID" value="CAJ1935780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJN3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="136" mass="14622" checksum="F426F5A0E375AFC0" modified="2024-05-29" version="1">MTTVVTELAERRSAAKGRKRERNLDPSTERKSAPIDPRSPAQGFFPDATPKPVCDSVAPDKDDLVMMDTTGPSVISPTNKPVNGEFAYWSDNDGSESVESAPDFSAPSNSDQPPTEVVVGKSPAQLSGPMTPRQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJY9</accession>
    <name>A0AAD2FJY9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042096409" evidence="3">
        <location>
            <begin position="35"/>
            <end position="2669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1561"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1617"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1705"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1808"/>
            <end position="2294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2316"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2388"/>
            <end position="2440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2497"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2541"/>
            <end position="2572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2591"/>
            <end position="2669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1456"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="963"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1248"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1270"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1314"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1332"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1727"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1762"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1852"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1876"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2168"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2201"/>
            <end position="2216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2231"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2339"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2422"/>
            <end position="2440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2601"/>
            <end position="2612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2645"/>
            <end position="2659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2669" mass="285925" checksum="EA9C12E04265EA16" modified="2024-05-29" version="1">MKKKISNSHDGNLPSGRILLMMMCIVASVPCVQSLANNNNNNRNSCPSNDLLDMLDNNSNNNNNNKEALGLYGVHDALSARILEAQLPENKNAALFVSGFGISASRLGQPDAGLLTSTELQDSTKQILQRTSSRLPVLVDGDTGFGGAANIRRTIRDVASLKAAAISIEDQTFPKRCTYVAGKGITVLDRAAAKERMQWALAAQQEAYEQDGNQLLIVARTDCRMQLGLQEAIERCLLFEELGADIVYAENLQSQDEYLKLRSKMQESTPMILAQVQTGDPEQTTIWNLQEIRGMGFDMGLFGVSGLQATVSALEQVASEMMQCGGIVQNTPLASLEQVKSVVGFDELDAFQERATTSMDNGNKRRIRSSATALSAHYSRGGSPVRQSLARLSSRSPHRRRFHTVLWSTANDVTEPDDEQGPQAPFNRMPPPKSDETVTDQVEETVSKVDSDDSNDKVEPTETTESSSDDEKTITLSDDTISNLIDPLAASDVKGAEAKSTYDPLKAKFPSPETTSSNSPFAKKGGGSPFAAAAAAAAKKGMSSFNTAAAKKGGGSPFAAAAKKGMSSFDTAAAKKGMSSFSTSGPGKQSSNPFFAKKGSPKGMNMGTTTTTTSDDEIKELDVEEEKTGSKAPAKSSFVPKTSKSDFGAPGSPFTAAKKGMSSFTPPPKGASSFAPPKQSGNPFFAKKGSPKGFAAKTATSDDEIKKESSDDDEESEETTASAKSPFATKSFPKKPAASASVSPFSKDGMASFSAAAKKGMESFSSAAKKGMASFTAPKQSNAPFGGTKEAPKGMSQDSGEDVKELPSNENSVGSSKAEAKNTFASNSFAKSNDTAAVSPFAKKGLGPPSAAKKGFSSFAAPKQSESPISGMKGSPKGMAMDAGDELKEEESSDEDSVGSKAPAKSSFVPKNTKFNVSASSSPFAKKGMASFSAAAKKGMASFTAPKQSTSPFSGTTASPKGSSKDSSSDEKELKKDDSVSPSPFAKKGMASFSAAAKKGMSSFTAPKQSASPFSGTTASPKGFSKDSSSDELKELKNDDSASSSPFAKKGMASFSAAAKKGMASFTAPKQSTSPFSGTTASPKGSSKDSSSDEKELKKDDSVSPSPFAKKGMASFSAAAKKGMSSFTAPKQSASPFSGTTASPKGFSKDSSSDELKELKNDDSASSSPFAKKGMASFSAAAKKGMASFTAPKQSTSPFSGTTASPKGSSKDSSSDEKELKKDDSVSPSPFAKKGMASFSAAAKKGMSSFTAPKQSASPFSGTTASPKGFSKDSSSDELKELKNDDSASSSPFAKKGMASFSAAAKKGMASFTAPKQSTSPFSGTTASPKGSSKDSSSDEKELKKDDSVSPSPFAKKGMASFSAAAKKGMSSFTAPKQSASPFSGTTASPKGFSKGSSSDELKELKSDDKLASPGQKNGSPFGIGGSSKGMDKDSNDRIAFVGENAADEIAAGVTEKEIAEKNAAEEAEIEAAKLNAKEEAESALLAVENKAAEVAEAARIAAEKETAELKINEEAEAARLAAFIAANKKAAEEAEAARVKAEKEAVEFKANEEAEVARLAAEKQATEEAESAHIKAEKEAAELKAKEDAEVARLAAETKATNEAEAARIKAEKEVAELETKEEVEEAEAARINAEEETAKGRRKAVKIRIVELDEEEEDSDDEIFDFETDDEDLLEQIRKSQAALENYSERLGAVLDEQDMISKGGIADSDSSAQPVQVEVIRSGDSTDSRSGDEGDKNSPAYSPDRWFSRFGGKTLDQVSPPSDSSGDGSEAVVRKDFVEGGDGLRPIPQATEHWFDEKYSRKSPAFGMEKTSFGVDQVKGKKRSGDQGRLIPLQDEGSAWYADPRQGLPSRQETSQPAELQVEDATFTKGDAEGDSGDSEQRDEENSPITTDPTLFEPKATWFDKPGVKGPYMTPSSGSKKPEVDESVLRPVDITNSWYSESKGRSKGAYGETSTVQKPADKESSATEGNQPEVREDAPSKIDPSLLQPKATWFDKPAVRGPYMTPSPGSKRKPDADESVLRPVDITNSWYSESKGRSKGAYGETPTVQKPADKESSATEGNQPEVGEDAPSRIDPSLFQPEATWFDKPAVRGPYMTPSSGSKKKPDVDESVLRPVDNTNSWYDESKGRSKGAYVVPPPSAPIKKTPDPDDDSNSFHDEEPKSPPTESKTNESTIPLRSFEQQPRWFDEGSLRKSKKPSQPTNSISDQPSQGEASVLRPFAGASQWFETRKPKWDTSSEPKAENSPPKADDSVLMPFETGKSWFEESNFRKKSTPSTTSATNEAKPPLKDVLIPAATTSSWFDESNYRDRMVGAGARPINPEGPADITPTTDEPSDDQKEEIKLEQEAQQEHLKAKQEMLEKEREELELLRQAEQDRLERLIAQMEAKGRPEEEASDAELEMEQEKAELAGAKQAEEEDRLRAEEKARRSAELEAERKRVQLEQELLEQEKAELALAKQAEKEERLRAAAKSNAELKAKRERLKEQQELLEKEKAEVARAKQEEEDRLRAAEEAKHNAELKAKRERLKEQQELLEKEKAELARAKQEQEERRRAAEEALRDAEMESEWERLKEQQELLDKEKAELARMRQAKLATPKQGDEAPPLDKDVLAAASELAEDSTTPTTAFNPMEGDVGTIGPDTNWRDSHRSMNDRMNDLGDTMNGENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKR2</accession>
    <name>A0AAD2FKR2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="225" mass="24982" checksum="9900F699E2921F25" modified="2024-05-29" version="1">MLSLDETLRLNNEGVALFRANEPSRAAEKLHSSLIGARSLIHRGTAAADHPNAPDLLQSYCEESQHHDCCSKDRNEFFLFLRAFAFRGVPEQQGGSTQAALCVYSAGILFNLAILHHKHWMKDGSPAFLDKAVVFYHTVLQIIQANGAYEHIPTLLLLVLVTCNNLAQIELEKGMVENVNQHLRYMTGILYTRKRTLLMTLTRIEVEGLLSNVLSGGRLSTALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKX5</accession>
    <name>A0AAD2FKX5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKX5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987:SF1">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="184"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="504" mass="57424" checksum="CD2395A4F4E1859D" modified="2024-05-29" version="1">MNTTTGTVSRIILGSCNSQHHEHQPLWPVVQSRNPTSFVWAGDAVYADDRKVEKQILDASPEYLKHLLQEQRNEPGYKSLLESGVEIFGTIDDHDYGTNNGDKTFRWRRENAIEFVNFLDLPDTSPMMKRAAAGLGVYGVQVYDFNEPNPRKRLLSDEAAGLDPDVVPDLDPSATQEPLSIGNRLVAVFVLDVRSNRTPWPKTLKEKVMNKNDGCMLGDEQFKWFETAIGRSNATVNIIVTGLQVHAERYYDSAKVENWNGFPKSQHRLYQALLQPNVRAPIVISGDVHHAQLLRKDCRQRGSNTLRPLYEVTTSGMTHSWGSVETSTCGRIRLGRLCNVTYMNHAKRFVLHFAHHIFPWNELIVDDDSNQMQYTLNLNVAELEFDWEDRQVFTRILGHKGQTILEQRWPFRSLTSIEETMVADRDFQSLSHRLQRQATIIDQDDWICVHYTGSPSPVSFAMASIATASLVSILLSAPLLIPILLLWLLLTKRRKRSSSKQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL97</accession>
    <name>A0AAD2FL97_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000857">
        <property type="protein sequence ID" value="CAJ1939854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL97"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042287878" evidence="1">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="98" mass="10696" checksum="23F625E8748F3C36" modified="2024-05-29" version="1">MKFLLASLFIAAASAFSPNSLPNGRVSKTDVNVVDPDMLHHLAQYGEDAATAMFINCDNAGCELVEGVHDSDGWYFDSKGPVESHHSQMLMMSMEDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLI8</accession>
    <name>A0AAD2FLI8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="121" mass="13651" checksum="70FF90A7881656A8" modified="2024-05-29" version="1">MKPTNMDASSSGVKRTVAMKRKFFLSKIPAMIDPMPNFLSRCNKKSRFEFIDEALRIVNSEEIISETLVVTGPLRRKGSSLCERRAIELLKDNSAHLSELLRKSQDDLADSSSDDESDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLL2</accession>
    <name>A0AAD2FLL2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001046">
        <property type="protein sequence ID" value="CAJ1941608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLL2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041971703" description="Thioredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="37"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1941608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="25438" checksum="1568A79B453562EE" modified="2024-05-29" version="1">MTRISRISHQRLLALVVLLMTSRVIAVAGADNDNDSAVVSLTSATFEHETQASTGQTTGKWLVKFYAPWCGHCKSLAPVWEDLATVVANTEEEMTDFVIAKVDCTEERDVCNRFEVRGFPTLKLIANHQVYDYKGGRTLEDLKAFLKSGDFGEGNPVPSPPSWVQQKMAENKFLAALNEDFNHIVKYRKNAAAVLVGMGVIWGMLIVAFFQMIFGGGGGSSSRKTSKAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLS9</accession>
    <name>A0AAD2FLS9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLS9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041962913" evidence="1">
        <location>
            <begin position="26"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="287" mass="32810" checksum="4DE12A8E0D65E1A9" modified="2024-05-29" version="1">MVAMKGAIKATTTLFLLSSLSSSSAFQNYDSVISPAPKESTSFWQVEINEFFKKAVPAPFRQSISIFYEKDDELDPEDFITIITAAPSSPGFPRPLWAVLMASIPTGLFWYAYYKFAVEEELLQTEIKQGKEPRGLGGYGTLGPFTYGLLLGPIAEILDTPGGMQWSLLSGVYLFCSQVLLYERVNDLYHEEGRERPLQAWWSLPLFFPFNIIVGLRQVHFLSQYLSRQRGLKLAKDPVCDLFPFIEVESLTWQQFMVSPKLWCSWFRDIDNLDPNFLLPKDWQPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM38</accession>
    <name>A0AAD2FM38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="140" mass="15541" checksum="4806C32E485BB5A7" modified="2024-05-29" version="1">MSKPNSDSSYGFNLETLGCGGKINKLISAFDFGSRPPPMDKDTDDTYAAQWAANEERKKSFSITDAFQCDPRTCIRSNVRVATKGAEPCDPEVCRQVYYCEICARCPRHCDCTVENDPSICDSAEAKSQADSFKMPKDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMV0</accession>
    <name>A0AAD2FMV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7467 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055890">
        <property type="entry name" value="DUF7467"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF2">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24269">
        <property type="entry name" value="DUF7467"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7467" evidence="2">
        <location>
            <begin position="5911"/>
            <end position="6003"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7467" evidence="2">
        <location>
            <begin position="7952"/>
            <end position="8054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1512"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1635"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1782"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1885"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1975"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2204"/>
            <end position="2224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2289"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2416"/>
            <end position="2441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2511"/>
            <end position="2561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2732"/>
            <end position="2762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2825"/>
            <end position="2877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3054"/>
            <end position="3074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3139"/>
            <end position="3195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3266"/>
            <end position="3291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3361"/>
            <end position="3411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3582"/>
            <end position="3612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3675"/>
            <end position="3727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3904"/>
            <end position="3924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4632"/>
            <end position="4688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4759"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="5138"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="5457"/>
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        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6159"/>
            <end position="7856"/>
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    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPL6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041920325" evidence="2">
        <location>
            <begin position="23"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="40716" checksum="D8EBC1AC72935F87" modified="2024-05-29" version="1">MSHRHYPKCLLGFLAIVHPSLAFAPNFQLNSHHHVLLDNSATIEHFRQTIYEGESTATTLYASSPDDISKGDEKDDFDVEAARRKLESMMGTASDETADSKEVSSEGNLSFPSSSLQVLDDLLSSSKTMKTEEDIELPSPPPLSTIERDRRNAEIQLLKELDVTDEASSELWKLWYSERGGTAKKKLEVVDSLMGNPKTWKMTETVLREIIDEYGIYFVEPLNRLATLSYLQGKFDESYKLCLVILKVKPWHFGALSGIVQVCIGKGDRDGARDWAAKRLPNMVAGDSFPPFATDGPKNPRRKKWVDKQVAAAEKQLKKIEQETKRSFGKPDSYVSDEAKGDIGSASESSDSGIQESDDNTGAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQD3</accession>
    <name>A0AAD2FQD3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQD3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="26453" checksum="5ADA65D4E58BFF8B" modified="2024-05-29" version="1">MENITEPTETDESGSLHFQAPKKDEGAPVKGRKVFFHSRIQCRTRLNKAPITSPDNLWYSKQELASLRKQNKRVKNLGMSGFTSFIGDDDTEAISFVGLYSEMERKQRAQRIKEAKKCVFGEQMQQEEDFYNGVRTLYNFKLDQESIAEFYSIYSLRAAKIAQMKGLRLARHVESLSAEECTFIDDNHRPCSQHSYSQRSKVTSENRLVRKKPSMRSVGNLIARLTTPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQJ6</accession>
    <name>A0AAD2FQJ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQJ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40535">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40535:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="677" mass="76336" checksum="E4065C0A8F98E9A7" modified="2024-05-29" version="1">MSSEPSFDNVLDDYLSLAIGVICAWLIPHVAIEIAEYRYEISRSPAWKGYERQTKGMDTITNAAIFAVSTAGISLAGSAAVVALLTQGMDWRVQAIVTGLSRITGAVVIFFISYKTPKWIGVYWSNKHDYGEPVGATERHLRFNVQWSIWRLFGQIYFLSLLFFCGAEPIKIPLSAFCGIVVGFVIWYFVYLGRTKLQQQRKKVAIFLASLISVASAIAFSSGCWYIQQVWGRDRRNDDMLTFGSFLTWLLLAGMVHVAMYTNTMRKDRETAALPPEQRKRRKYRTRHFHPKHMSKLRRQLERSCSTDENQELERDMDDSSWDHEREMNGDDGDDIFVDISKDGKEDIEGDDLEGDEATRNEESGSSLSDVEAPKGANAASSDKTRTDAAGRLRRLDSMDTNDSELLLEEITENESWFSLVRLHCCGNAERAGERPKKSRLEKTVSGFKWTMGFVVNAFFAFLVIVNIGATHQNNAVRQNLPKAYELLYPPDYNNGTVCAWDNNGPDSIIQTFDTPDDARAANFSIVHCGACAACSTWQDLRLQWTTRSYLADAAQDCTKRAFLGGSEAVQECNEDEDMIGFSEECATCWTVDQLCAKKNCVFIFFQGVMINKLTNFQVGPNEITSATCDEAMCGPEFVPCSGATRRRMDIISTIARPLDQQCRIINQDWETIFDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQU1</accession>
    <name>A0AAD2FQU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS12366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQU1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="37"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="134"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="256"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1949989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37754" checksum="CD0C8B0BB5DC2F47" modified="2024-05-29" version="1">MTLVGTDGKDEHLANTTITQSSNDRSNDKSGGSTNPILLSHNIAGSVVAGCFSTILGHPLDTIKVHQQTKPKFAKATVLDVAKSITLEETGSKRNITRLFRGIGPPMANQMVMNTVMFTVFDSIKTIATKQNMEETSAALWSGLFAGFATACISTPTDWIKIQAQTSLVNNQTNISTGERATTTVLSILKREFVSKDNGRIQWKHATSTLYRGHLANLGREGIFTMVYLGLYDRISHVVRRQHSHQQNNNGVDEDLGMASVLMISSLTGACAWLCNYPFDTVKSIQQAVGGGSQRMTLSAVARQIYQGGGMMGFFRGAGPSTVRAMMVTSSRMVAYEKTIQLLKGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQY2</accession>
    <name>A0AAD2FQY2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQY2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="112" mass="13078" checksum="003856FE52790B89" modified="2024-05-29" version="1">MTKQATRKTKNVFQQMAGCFKKSDHKTKIKYNEHLINKRKREFGIAYMNLVLKNASEQELRLEKEGCLKDIDKLVKEIEELETKVEQVDVETRSKIHREPSTSNPTIEQTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRH3</accession>
    <name>A0AAD2FRH3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ChrR-like cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRH3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20303">
        <property type="entry name" value="cupin_ChrR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="244" mass="27385" checksum="A457D54A0B6FE290" modified="2024-05-29" version="1">MKINANFKAMAAMNFDATKYISSPSYGVNRFMLDRIGSEKARATTIVEYKPDSSFPEHEHVGGEEFLVLTGTFKDKFGEFPAGTYVRNPIGSKHAPWVDDDGCTIFVKLLQMAETGEGTKSLHVECSKEKSSKISDGSSALEMYYNEATGERVQMFWLEPKAEFSIDEYCSLGEELFVYDGSLEVGDGEEYKKWGWLRFPAVSDADEKRKTLKAGSQGAQVFRKTGHLTEKALSMEKIQIKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRY1</accession>
    <name>A0AAD2FRY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS12873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001776">
        <property type="protein sequence ID" value="CAJ1951028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="365"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="398"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1951028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="837" mass="95537" checksum="1CF0CDE8FA576A22" modified="2024-05-29" version="1">MEILIQIPQWLVDMLELAYSKGETAYNLLLEHFSSIWSFVTYQWNSLFLMLSMIFFWPMWVYIAVTLTTASTWIFWIFASLLLGLIQMIYVSYQFVMIANDVMILTCLKTYQVIMRSRTTQFLFFFSKTLRKKRIRTSRRRKWRCECELAKSYSEFLQVQVMEPKEPKLEKPPTDVNKPMKRRTHSFATMQTLYEQQDEITNQGAESPRRRAHEMKRMSSFSRAVFDFDNDDTTPNMDPTVAQDLGEMTAELLQSTLIRLKEARKSCTSQSDLSSLEHLLSGVVKRNHLTLEDLVVNNARAVAFSGQYGFSAASRRQIDAYYNEVSKGLEFLAEAPVSVDEPLAVLSDRISLVRKMKQNMGRTALMLSGGGAQAMYHLGTLRALIDADLYDDIKVISGTSGGSITAACCAMYSTKEIFEKICVPTVSTDFKLNGEMKQKNIKWFPPIQDMVGYWLKKRLLVDSEYFYRTCEFYYGATTFAEAFERTGKHVCITVSASRASGGTAQRLLLNHISTPHVTLASAVAASCALPGVMKPAKLQTKSSLGEIEPFEVDGVEWIDGSVQADLPFQRISTLFNVSNFIVCQTNFHVQPFLNKDHHPSTRSAYWKLFQLFEWDIRSRALKLGKLGLFPKIFGQDISKVFKQKYHGNLTLVPRFTAAQTFGLKALVNPSVKEMEGYLKYGQVAVWPYVSVIRDMIRLEKSLDECLDNLKVRCSKLHVEIDMSDSDDLDSIASSSASLNAISLRRSSVRFGHHSEIERLKKKLSKLEDENQDLREKLKELEQIILANVDQQQELNEKKKSDDKLGKPVEGDKAQDVSEGKVWEILRDLDRRSYTSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSJ6</accession>
    <name>A0AAD2FSJ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSJ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="721" mass="81951" checksum="C2D1F9FF3BB154C3" modified="2024-05-29" version="1">MYNTGTAETLRGGRRNKSLLSTFKKTNSTGKLMDDVDAPVEELDASDSAGSDADLIFFQQAHEEAQPARNARRRGSLLSSLKKASSTGNLMDDLGEREGNDDFDDLNFIQSAHGESEYNVAETPRGRGRRRVRSLLQTIRRSTSKKRLEDDDFENDDVDDLRQIQNLEDIERSIPSNTPRSEGKKKRLRARLKARESNDVSDLVAESNHAIKSGKDPRRVSKSPARLSKEHALSDPERRQRKRSSKSPARLSKEYTLGDPERRERNMNKEKSKSGMDKRLSTDSQNDHYGIPLSFEQRVQQKVRQESLTTPRPKKRNIKSKLQVSGLDLASPVEKKRTKRPGRSKSANDSLIHDVSTISTKDMSTDASPGLSERNQDCGYDSEGRIGRKKRVPRPRKGRPVKEVLIGSESPAALSPHQKLRQSIMNDLDGLEDRSSIATMYLHRQVEALKKKVEKLTKTNEKIQVQLNEEIDLNGQMAMKLREHELGLAALESVNDTKVKVEILKKDHEDEKHEMDLLLKEKDIFIERLQQKINSIRVANSTMQMQRDSPKTSHTDTSGHDVKGLQKKVKAQDEEIEDLTMKLFAVQEQRGQDKRYINNLQGELQQTKDEKKKLDVELQTAKKEHAKAMKRKDETVDFLQDSLLKLKLKESKQRNKERELAGSPAFGRGKNNRSPRKKSPVAQFSLSPGRLSFRNLKVQDVVLDDDDPRSQSTSNLCFSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSR4</accession>
    <name>A0AAD2FSR4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSR4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="526" mass="58997" checksum="06B669D5C65D3659" modified="2024-05-29" version="1">MKSFRKGRSTSAGPAIRARESNTAPVLSARERMEAYNQSYNRPTVPTRSKRNPIMDRVSSKRNAAEATATATAQPLRPYSKHAPSNRSATLVTHHQSNAESKPSLNVSKSYRAGKSNRRLEFQQTQVQHAQSTHNCTRYSRDFQKRSSRDSIQRQKSSSEGSTLPSRQVSTGDETYSDAHSRLSKYKATMGSSYRSDPSYLVPLLAAQAYHIPGNTWFQDWRQFMRNNHPLFGICLHHKLHPIKSCTRMIALCGSILFGLVMTNIFYLFYLWNPEFDQIVMSITLDSGEIYTLTTGMLLLWTVGGGIHASFNLCLWYIAACSCCRAGGCCEARACCPSFGKHLIRGVVLMIVVMTVLVIVMRIAIGNPETDTLDDAAATSNVTDSNGIDFFFTDEAWDFNVKGTEEFHFVLAYLVQMGLSLFVYYPVFATVLMSGVLGCNGKVPLLGGRPYEVAQYKRKQQRVSKLGNWDSSGSPTYLDSYCGEGSDEFALNFSFVSDDRESAHEDDIEILWTPKAKREFERRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FST9</accession>
    <name>A0AAD2FST9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FST9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="352" mass="39895" checksum="1EC400FFF7FA7308" modified="2024-05-29" version="1">MRQLGIINGSLSSSSIAAPFEWADPTQLVKEGVSEISTREIGDEGEQIRISHGNSDTILPTDNKSSNNNKSSNNKPRVVVGIFSRLNDVEERQRRHLVRHTYLRFDLNHPPTFQQENMNLTKSNDNATKAPNRICSLAEFQQRHRNSSQNSYDGACQLIYAFVIPLEEHVDATDSAPTDDSYKEKTSSLPSIASDWYSSSSSLPTEYPNDDCLDEDMIYFRFLATKQQQGLPSPLRPKVIASWYAHLLSEVQYSIPIDSIAYTDTKVAILPTKFWKNAIFHHRHQDRHTESSPYSTFPRSLTYAGIQVQKSKCQSTSCPSLQGEYVMRRWVCLSRGVIIATAFHKGVHERSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTR2</accession>
    <name>A0AAD2FTR2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001823">
        <property type="protein sequence ID" value="CAJ1953201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1074" mass="121185" checksum="F5BC9A42BF551139" modified="2024-05-29" version="1">MVHRWIKCRVCTVAHDIEIQQFSKHVRQKKHLKRVAEFESTKPSAYVQQEIQFAERCQIAQTTDMETDTGPSPTQHSAGDSNDNGMEFFSHNDEWSSIEIDDASNAPPQLTSEDWMTQILSKCPNPKGDLSGYFSTEEETTPIDGLTRTPMNAQYFHCNLEFGWGPRLLTAWAAQRNTSLDILQRMGATNPLFCILLAYLTNRLTNIEQRVLVALMVYMSDPLNRGLPIPENHAQLRNCYGPDGRESIPNILPRPIIQILDTGFAYVSIRDILQFHLANGQTLDPLVDAPYSPQSKNVQSLHGSSQRGKDLVAFSNEQSNTQPTEFISEVVIWSDAFDTNNTKNNRGSVHVVLVSVGTPGDDYHSGRNTYPVSLGPSNGDMTTAMEKLVRELTELFKGQKNKFFHAASQKELAVSLRVYCFLQDRPERCSWLGLAYGNGRYGARFGWAGDLSQSCAYKRLPSCSDCNALRLCSPDVRHFQCTRCSDWRMDLLSYQIPKDYPTIFMNNNSDGTDPTAQNLPDSAPTDARVNGNCLRFRPITFPILKSASDSTFDMVRLRYWTKKQGIAYLETFGLSQVYIADLCNAADNPDEQQPPHPTTWNVPGVDIRHHIDALMHLCFLGITKAISTDLISGWLKAQRKSSSFYNLSHPVLDQIKRQSLSWCKVETKFGGYVSENWIAYCLVYKYVHQLLSKLTEDDDVYIDPPGVPLSQYNLKQRRAWLCARKVEDISNKSLKKAVDKKFLEFISLPPEECPPIIQPVASKATLEQASHMIICWQVCMSRIMSLDQNPSGAQLLDIERHIKVFLTSVDVFDLTRRDQATKKDMKVPVWRRKQNFLGLLNFRDTIREMGPLCPLSELDLNGNWAYNAMKKYFVEKSYKFALGACVRDVTNGLAGGEPGSCQAMMEVATEIANQASAPSTDSDTNDDDAFIQVRSQANYKSHKDEATAMRRLEESEFMSGLVVDDHLYLVIKTGGMNTYLEIRPVEFHLEVCGAQYFSYTTVASSGLESSRFKSCSEHFLLLPLLNNDGSVPKGKGRDGERNFFYVITSGWREISRSDRAGFVLRLPTIPGATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTV2</accession>
    <name>A0AAD2FTV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">30S ribosomal protein S9, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS14022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTV2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1953414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15993" checksum="A9BE452EF41D9897" modified="2024-05-29" version="1">MAPVNSVQVFGKKKTATAVAFAKQGRGLIKVNGQPIENIEPEVLRLKVFEPVLIVGQDKFANLDIRIRVKGGGITAQIYAIRAAIAKSIVAYHAKYVDESSKNDLRKTLIDYDRTLLVSDPRRCEPKKYGGRSARSRFQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUI5</accession>
    <name>A0AAD2FUI5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001830">
        <property type="protein sequence ID" value="CAJ1953543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="199" mass="22755" checksum="76228FCA993DD0F1" modified="2024-05-29" version="1">MTTIHRISKYGKLLILVQRTHTPALGTIPNLLFIGQFYDENPDLMEGDSKPLPPHPPKFNNRDGRIMMENIESWARTAYGYRGIRLDYIFRENSELPVAGDPGFLRADDGSRSIKEELVRRAAHTGAVFRCNNQKFWVMLHAVTHETDAYNHVRQFAPTLDGQAAYFALFAQYRGRGHFTNERQAAVRVLATLHWNGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV01</accession>
    <name>A0AAD2FV01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001818">
        <property type="protein sequence ID" value="CAJ1953105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1958" mass="218872" checksum="0597915EFEC02033" modified="2024-05-29" version="1">MTSRLHHAFTPFSNGGSNPLMLDGEDKDIDDSKDERRQLIELFQTYADMYPNPRLVEEYRLRDTLLQAASAASVASASEKKQQAKDRGFFSRWWFGDDDVKSEEKEEESGSFEGNANVISEDPLVYLDADVETEDETLCGTMHGLDLECIPTEVYSLARFHLASTRTRHNKANVFREGVTFSSSTRSLVVVGLGQIAELSTQQEPCLSKTSDRDMLAAYADAKEQFSLSYVRATVITDNCIAVSWGFLDGIVVIYRRVQNATSSIGWETVWILGPSNGLLENIRGREFFHDDENHPSSPMLRVSDCLPLQVETGKLSEPTTIILVLARLGGYIELIPLPQGVWDGPALGEQNTKNASKVGLRNTIAHYTSGRKIESPPNALALTTSQCHIDVLSLHALRTSASFGSNWNIDAFPDSPPSEHIICASGMNEDGLEVVSFWAMSAIFSEAQDRHFGIGTQLHSSLIEAITTRTGADISFFATAGIMKRWRKPKSIVIREGRKFNRLPVADLKIQSAFQECTTTISITAPIVKLELNVRKNPDHGAWLTFMDWNGGVEILDCELIERFAAQSASSEEFNKYQNADPSVSLATTIAGRNQIANILNKISAASTKASLQQSTIEVCDIKWASPVDLQLQNVDYPFLILFVKTVGNSAVVALSAKLSLKFVALTGNGEAIKLCCTNSLTLIATKNGRKRKGMRHFALQVFQSQEKIGTKRFDNDFHSKSGRANQAINSLATNEDPSIIVSEVLSIVRDGATEGTMTVEYLRKICHHAICRGGNVREMENQVQEIMSFLVKLGTFQLVCEHLSTEPSLIQFWEKFQNVSIPVIAKRFAARADICALTIITYRHRVKLDDYIRVLDSIPLPTDPTLFAHLIPTFRQDTIGRSFLFADDADHIVTANWSNLPSFALQTYGIQLFLDHDDNDNVLKGFLDGQDVTTDDAAVFWMWLFARAAFMQSFIGNVKHTILLLKLGVQSKSHSMSHEFEETVGSIQSNLLYSSLMSFIIEVGKFMVDGKEIINRLSSDDLIAMKAQEIVEITLRGEICPAKVVDKCFRFLRPLAKSMTHGKIAVFDLDNAISSFCIGLVEKYCANPLKKPQTKQWFHGFLCSVFVSLAVAEDSRTSKPRDMRIIREKMELLRMVKSILVVSALTFCNLNVTQESCNLFLNTFWQLCETLPAPMPCRSTSEHEYDTDTLFCSNALLGFEIFLQWPGCFPFCFLSKFCQVHPNCNMEEFGIPFIIELCDSFCAQVKKRPSQEDLNMLLSDLLEDVTKLNMLCFQGSINLPFILTKYLVPLLLKLEAFEVVMRLVEHHPNFIEHSGVELEMLKLIEDENLVEEEGSARKVLWFQDHANEIKMIFPDIVLVLDPLDRCIKACNFINSFIFQGSADVEPMTPIKMKYVLPFDLVDCILEVVPESVCYGCPQWVKPIHFSGQLLQYGKHYTNGELENDPKQVGEAILYLAAILGCTDFYSTALVKCKVVEVAVKEGLQEAAVRLCQTLIREWQITSVKNYATTVGIAGAIHDSSMDKSFGNSLARWELCQTFIREMYCLTGLLCSRSVLSIVSLCASLDLECTCFASDQQHMHSSQEESLVLPSLLADGSQCPEQQSSLSMLLRDFHLYVSLGKIQDYTTTTLCMRLIDIYITTLKTKTRLLERLFSYQIIFLGCVLGLHTSGSAALVALIHGLLESVDTELHYRHEDNCDTRSTFIYSPNSEVVNNLTKQGYSKCAAARATIMSQNKGYSAAQEWAIAHSLQTKSNQPFLSIQSSTKASSADEPIQTLRKVLEKLEYFGASGKAEFLLLHNPQARPSTEIHSKPQSFVRKQAMNDESTAVDSRVRGGAQSNRNFQSDLMWQHECSHKELSAHNSHRTGVCNKEGSILHVERSDCRQSLAPGALLSGQSTSELRVLETGQQQVSERVANRDNGATCDIARAQLIEEGRLLLQKTMRKKRSKALSTTWSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW50</accession>
    <name>A0AAD2FW50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS15346</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1954754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="122" mass="12841" checksum="9DA2145579F75772" modified="2024-05-29" version="1">MSGKGKGGRGEKKSTTSSAKAGLQFPVGRIGRYLRQGKYATRMGAGAPVYLAAVLEYLCAEILELAGNAARDNKKSRIVPRHITLAVKNDEELNKLLGGVTIASGGVLPNIHAVLLPKKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWK5</accession>
    <name>A0AAD2FWK5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS14938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWK5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042061040" evidence="8">
        <location>
            <begin position="21"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1954346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="304" mass="33102" checksum="B48A95812AD7EACE" modified="2024-05-29" version="1">MKFISSITLLGVCAVNTSEGFQLNNPRSASRSLVASKIQEYRTPSSKHSIRRQQASALYAATPQESPSKDLDTDALVKYGSSIGIQMGIITALLYGLDTLVGTIGLEVPFPAVFALFYFFSLKSRTFNPLNNQRPNLKKAVNGEGTPSKGFRDRVMPSWTPPGVTFPIMWILVIGPLRSFSSALVYMANGHHFCDPTLLALLLHLSIGDVWNTINNTEKRYGAAVPSVLMVSAAAANAAFQYSQVDPFAGKLLGLTLVWFSVASTLIADTWRLNPDPSTGQRDPLYPVTGGESKTEFSWFNSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWT1</accession>
    <name>A0AAD2FWT1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001871">
        <property type="protein sequence ID" value="CAJ1954960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWT1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="163" mass="17951" checksum="202A4AD2666F85BD" modified="2024-05-29" version="1">MDTNADTCCLGKNFVIMSYTPRSADVYAYDPALPPTNLPIVSGATAFDCPQTGKMFILIINEALYYGNRLDHSLINPNQVQSFGIPLWDNPFDETRHVGIESKKIFIALKAKGTKLLLDSRAPTEQELATCLHIDLTSKVPWNPGTVQLGKVSAAHVVLFLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYP1</accession>
    <name>A0AAD2FYP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24441" checksum="0427ADD25B72F40D" modified="2024-05-29" version="1">MSKQKGKGRKAAFNLDGPTTDGTPKPSVIAKEEEKQPTTDSQQLLRLHHQMGHISFGKLPSMAKQNIIPRRLANADIPRCTASFFAKATRRQWREKRRKHWTKEQTITRPGEVISVDQLVLPSPGLISQTSGTLTKKRYTYATVYVDQYPGLSFVYLQKTATADETIEGKKAFEAYCKQHAVRVQHYHAGNGIFRAHKWVGECRRMEQGLFSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ38</accession>
    <name>A0AAD2FZ38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="484" mass="53375" checksum="61A633F733488910" modified="2024-05-29" version="1">MMMRDAVAHALIEDLAAGKLVEKSEFQLTEEQKNVRIPGYLIYLAGLIAKPSSPSGNTYTTDDAGVAISLTTRDNEQFESLQKTFANFNKNEMPIFRLSPRLCPTEDQLTSIQTDFERKKQELEKNASKAAEDLLSAEILNNRNEDTKPIDANVKSKTKKKKKKTTNTSNSIKNAVADSNSHEGNLPPPTSAQDQSTSTSAATLEQILSQIQTETTSSVIEEDADPSSWIPVSTKSKEYKKIGNRQNEHNSAKVEPPSRKNGEIDQLDTSHQAVDVTNDSDGAETPPLGTKGLSDTSSMEDQFSSTNKQDTLATKTATNTGEVRRVKNETGVLDIAESASFSTSIEALQERIRLLEQAVKAKDGELKQEKQANIKALCQKQQQFDDQVQALQLRLYISETRLKTFEEALEQHVQAVASNVSTSIECTSDTSGRSILHQYSSRKEWPIRASKSNQTKDKDSPSPLISRLLSRQSKMSDDVPSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ60</accession>
    <name>A0AAD2FZ60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS15627</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000096">
        <property type="entry name" value="Arginine--tRNA ligase chloroplastic/mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="13">
        <location>
            <begin position="253"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="12">
        <location>
            <begin position="715"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1955187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="835" mass="91358" checksum="7CFE8391115B99B1" modified="2024-05-29" version="1">MAEPEKKLSKNEQKKLAKKAEKAAKKAAMAGGGNPPAGGAPAREPKQPAPGAPAPVAAPAPGPTPTPTPTPALKVLIFNGDEGCSATLKAVWAATHYSVDVGVATKKDLPAGFSADKKPALIYGNDVVLGGGGNAMCKAIALMGGAEYSFEADEWCEFERTSMRGNAIGNLDSLGAALEASPTGVHIIGESDSMADICIISALSKHADKLSSWPSHVQTYYKAHIPALERVKAAMPNYISEPPVDLNDPRMIIVLTQIFLDSFESVFPNSTVPKTLVSKCANKKHGDFQCSGAMPAFASLKKSGGLPDGINSPQQVAQAVVAHLGADHAVLSDLSTQGPGFICFRIATSYLQHQVQNLVGKSLPKPNIKPQQCVVDFSSPNIAKEMHVGHLRSTIIGESVCRVLEFVGHKVERVNHVGDWGTQFGMLIQYLQEEYPDFSENMPNITDLTEFYKCAKQRFDEDPEFKKTSQLNVGKLQSGNEAFLKMWKILCDISRKEFQKVYNRLDVTTHEFGESFYNDKIPAVIEEFQKHGMISIEEGGAKCVFVKGAKIPLMLQKSDKGYGYDSTDMAALKYRLQAIGAQRIIVITDFSQGDHFVMCNQAAHDIGWVNAGQRLQHIGFGTVQGEDGKRFKTRSGETVRLVDLLDEAVSRMENSLLQRIESGKANITKEEVHEVAEAIGYGAVKYFDLRRNPTSNYKFSYDGMLDTKGDTAVYLLYARVRFESIMAKAKAEHGVDVEELIKNGEKIVLGHPSERNLALQLHAFGDTIGTTLDDLFPYHICEYVYNLSIAGSEFVTNCRVLGSEEMKSRLLLCHVTTMAMRQCFDLLGIRHVKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZF4</accession>
    <name>A0AAD2FZF4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sialate O-acetylesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZF4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052940">
        <property type="entry name" value="Carb_Esterase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31988:SF19">
        <property type="entry name" value="9-O-ACETYL-N-ACETYLNEURAMINIC ACID DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31988">
        <property type="entry name" value="ESTERASE, PUTATIVE (DUF303)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041985766" description="Sialate O-acetylesterase domain-containing protein" evidence="2">
        <location>
            <begin position="38"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Sialate O-acetylesterase" evidence="3">
        <location>
            <begin position="159"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1958214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="456" mass="50785" checksum="82BCC9C074B05130" modified="2024-05-29" version="1">MQNNRNAAESCTVDTMRVSNSLCLWLICFHLPSFLQGAVTERKSPSIRHGKVNKGTVHVFVLAGQSNMEGHGDVDARDHKTNTPKNGTLLYQLHDPRTRGEFKKLWDDKADTWRNLTDVKVWFNEFGIEHGVNGSTIPGINRKDYLAGDLSTGYGAGGNAHAIGPELGFGFNLKLPKGDKALIIKTAWGGTELASNWRPPLSTTTFDPYCVLPKCNPYQVGHLYQVMIEDVERLLKPGVLGKIYPDLEGMTPDIAGFGWFQGWNDGCNVNATAAYETNMVHMIQDLRRAWKKPKLPASIAISGFGGWLIQGQGRTPPDCWDGPNATKIHCHCDGDRDCRRIDIMLSQIAAANLTRHPELECCVEAVETRNFYRPPEYSPSGQGFHFNHNSETYYLIGKAMAESMHNMMWSIDGDVPGGHDQRKIVVPSSSSSASSIEEREAFTLDLDSNYRRIEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZP8</accession>
    <name>A0AAD2FZP8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001957">
        <property type="protein sequence ID" value="CAJ1957785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZP8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="127" mass="14445" checksum="4D7D71993EE9CACA" modified="2024-05-29" version="1" fragment="single">EALDFATPSFFVLAEAAFGAGDLPITTEIPDEELQDLQEDFDEHFGSSDNGSDEESLPELINRKKKQRHKSDDDSANESDYESKDNDSDIEMSEQNHDPSRDNDEIDDKLTKLIDKLQHMENPEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G191</accession>
    <name>A0AAD2G191_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002005">
        <property type="protein sequence ID" value="CAJ1959588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G191"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="163" mass="18812" checksum="E7BD53E8D6ACFCDA" modified="2024-05-29" version="1">MILPAEEDGCYFVVARQRYLPLAMNVLDNLPSFLQFHLGESSFLNFIQVIKNWSATDLAYQNRKLHVEWVPSELRSRCIEDPTNDQGPQVRDSMDFLLCMEDPVEILEGTHIGIHAKHVWDVDDGFSMIGYLDNWNENQAQLQTALQTIETITDEKNSLNRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2H2</accession>
    <name>A0AAD2G2H2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YEATS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2H2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="478" mass="53629" checksum="8D7C996878251430" modified="2024-05-29" version="1">MAHSVDFIVGNTYARIPNHIAKRSRVGGHRKIHDVTVFVDVVNDGNPDLLDKVSFDCGATFSPQIFTCACPIPTQTRNGTSVWRFSTRQQVYGPFDVKIKIYGAGGTTLVCNHEVQLKSNSEIMAHREPEMNFVEYKRLRPLSKIRLPDGAQFGIELEMSSGATITPEYLAYELSGDNRYQVQAYDYTHATVDHWKIVPDSSIVCNRSEPDCNKFELVSPPLGPGAGLTQVHAILSKVTNVNVKVNKSMGFHVHVNVSRYSVPQLVKVCQQFVKYEAVMDLLMPPSRRTGSVESNQFFASNRRHVENLARNSRRSVIDTLANCEDLQSLVYTMNGATDGSGRYFKLNLQNLVTGRQPTIEFRQHSATFEYEKVRAWIRFCVLLTSNAAKLRAPTSFSSDKTVDEQLEALFQYVLKDRDLRNYYRSRAQKHNHADPAEAACCDECRSAPNSVSSSSHRPAKQVRHGFTGFCVTTNSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G392</accession>
    <name>A0AAD2G392_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002087">
        <property type="protein sequence ID" value="CAJ1961178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G392"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1961178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="108" mass="12297" checksum="29B74B66988CD13E" modified="2024-05-29" version="1">MEQEVLEDIASRLSERYGKEAPLKIQRGHVHKYLGVTIAFSKKGKVKFSMDDYINRLLEEAPEDMKGLATSPAANHLFQVKDEPVLLDSKRAELFHHIMAKLLYLCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3N0</accession>
    <name>A0AAD2G3N0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002082">
        <property type="protein sequence ID" value="CAJ1961122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3N0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="61985" checksum="DC8630FFBF9272C7" modified="2024-05-29" version="1">MNANFGPILKTHSEADYDPTGLLLRCLACMVWHAKSFQEYIAHNPSNELVKVPFYNMRGSEIDALQQLITVEPTPDVMTTVTGVPPHIETTCQMKAIHDNLIQLLAQTRISEDNQKQRDEQLKADLVAAVHHGIEQNAISNGNITAKGINDIIQKHQDATNKQLTEHLQAMLRSLPPQFQGGQPAQIPPPGNQVQQGGGLLLQKPDQGKYFYTKRFWSVPEDFEFPPKPNLPQALRCWLKGIRYGNNYVKPFRQLRPKDLPTTALQSQMRVEWQKFFKYLENNGLEMPSNTSEEVTEAQLERTTDEMWDLLEKKVSYAFTRKNAKSHCLSTFARKVSPSEIVKNGNPSDKTYLESRQKAKPAARQYKNRVRPLAKNPKYLRRGKQKTTANATNPARLQQATIHAGAGILLEPIDHSPRVLNSTRYSIEANAEQDRMMEEYGVGRGPTGPPAVAIGHHDQTSPTYLQELIDRFGIRHPYPPISVPGPLGPCACAGCSKELELGRHRCARCNIVIHNNCAMDRNWYMQKNGEEMCFCSDQCKKNLPGGRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7F3</accession>
    <name>A0AAD2G7F3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002212">
        <property type="protein sequence ID" value="CAJ1965638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7F3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="87" mass="9784" checksum="CF027001A95EA818" modified="2024-05-29" version="1" fragment="single">MDVSITRQMVMDQAHHKEIIAAMAALGEEFSMRAATRDGEPDNDVYEKWSKQQIAKTQFQALEQALTATYVGLQQGMETPNQQLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G946</accession>
    <name>A0AAD2G946_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G946"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="242" mass="27543" checksum="A0D7160F2B817244" modified="2024-05-29" version="1">MGLRGNRYEMSVRRRVSSNNDDALNYYMKQAGWYDDDYSMQQYNSGAAESSKTSATSKGKYNDDDGVSVSAANSDGISMEMKLIAAAIAIAFAVIVFKCLSGRRRRKKVSSAASRATSRSEKSSSKSRPARSRSGTRTRSKSSSSAKGDEYHRMDDREHRPARSKERSKERSKDRQRSKERSKERPQSKDRQRSKERPRSKERQHSKERSRSTSNGRKSSRDRKSTKRSSRSTSRNRSSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9D9</accession>
    <name>A0AAD2G9D9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9D9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="218" mass="23536" checksum="5303858CA9FB00D5" modified="2024-05-29" version="1">MWSLSHAVTLNNQGVGLLLQHDHKGATTYFIDALSSVKQMLGGTQGGKRAVASNTPPALVHESTYNIPGFHDLNCFVFASAITLSPNVKVSDAESINDISAVILLNIALAYHHAGQVDRSLLTKAEHMYATASEIATMNNDRRHGTCLLVKAAATNNLAQIRHARGEYSHSLEGFNYLGSLFATFGQVIQRTRVEQDVYQGMLMNALLMTPPETAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9E0</accession>
    <name>A0AAD2G9E0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9E0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="146" mass="16182" checksum="ADC20AB5A8D61010" modified="2024-05-29" version="1" fragment="single">FLRRRSCSAKHRSNGIHERGKILQVNQDRDSKAKERSRQSCDEPASTTPGAVASLSTVERKKVRGSSKRKSASIPGAVASSDTVEGKKDRSSSKKVQRLFLGLWPLPRLSRGKRIGVLVEEVRRTKRPEDLQGRKGSTNTEAVFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9J6</accession>
    <name>A0AAD2G9J6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002296">
        <property type="protein sequence ID" value="CAJ1966533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9J6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="454" mass="51618" checksum="5C8ED5EF36461685" modified="2024-05-29" version="1">MRVSNILFKSAQNRRHLQSLALSVHFKQPDFGMREYEILSRASGFLLAVDPPDLSNSEGPYGHLGKSERERRLKLHKQDHKYSPAVGPANRELKDLGWLEFAPQEVRPTVHFVCSSHVLAPFLWKDYYPQDWLSKVKQEHCAYSLEVYDTESPGEALGKFALNPYPIHHPEGRDIAFIHLQQEEESLKIMKQLGVKIHNMRDLDSVYNKGDEVAFDGYVVAEQNMADYDELANDVVDETSSTAKNEDARVFFPYQEKGRLAYHTQDRFFAETEKPLPEGLCGGPVLDEDGLVCGIIEGIVDKNHANTQIAGSAAFMPNYMISPFIEYAERFMLQRILPKSLFQKAVTAKTTNSLGGGMTQGNQPNFSQQGNTTAWEEAFDRAVDQLKKNHTQEEVNAILNTIQEERNEVLDILDKEGGDLEEVAARVRRKTMEIREMIHEEYRQGQNADGARNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA02</accession>
    <name>A0AAD2GA02_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS22373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA02"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="47"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="554"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="689"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="660"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1966790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="83316" checksum="BA6BC35578DD82C0" modified="2024-05-29" version="1">MATNTAPVTGDRSTVLSYRRCIILAIIGSTPTSSPVLSQILEQGFLKTTRKWLDDLLNKSVGGVDLLLHMLTNITNLPVTKSVVKDSGMGKAIGSLDKHKIYAGTLNEDPIKQRTKLLKEAWNKSVKARKEAKPATVGTKREVAAPTSEPIKKKAKTESSFSSLLKKVNPKTLPKVAAAIEKAASKSESQEGQIAGSASKILSSIAGPNNKKMKRVKWSDHFGGNIIAYLDGSTVEVKIEGAEPSDMSDRRKRDRLREKELLAKAKRSKLMDDDDDDMPMTTASSLPTIKTTIDWHAPALLPALDDVVPPQVNSLEIATQSTRIASAAAATYFEGSVPSNPAPLSDVEQALDMASQTSAVLQPIPFFPPQAPVPEPAPAPVPQHTSYAPPPPASLPPPSSMGMPPQLNQSSAVATPEVVQSLGLPMFLVGQNVQALETLARNPTLLGTFVDGNGMYDQTRITSLVQTLTQNIAPTPPQGGIAGGYQQPTPSSSYGSGMQQQYGSSSGGGAYGPTSGGYGQSQPIQSQYGGSSSWQQGGAPRTGGGYQARTSTEGNLHLSGYGPSTTEAEIIALFSQYVQVDEVVMKGTFCFVNTSNPEGAKMARESLTGALLGGSPVRINMAQRKNRDSAPSGGNGSASAYGNAGMNGMSNMGMYGQAGSVPGVPSMQTPAPMAQGENVRDDRGNPATKNLFVAGYGAGTSELQIRETFGQYCTIIGIIMKGSFSFVNTSDRMAAIQTRQALSGTMLNGGVLRINFAKETGRLGTSFDLTYGGTVKPPGGGGGPPSHYGRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA71</accession>
    <name>A0AAD2GA71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Separase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2250"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2331" mass="259923" checksum="FDF039FF695D1E70" modified="2024-05-29" version="1">MSWAAANAPKRRVQGDESSTRRSGKQGSTETVEAALARLSKGYTTAMECIGSVHKTNRLMLKEKDKGHGGALEVLMRVSRAARTTLEKALLTDLLVEEHTPCLHQEFVDMKHALVASTDGVRRPLPPALSSEAHKSTVRELAYLALVNYSDLLLSCGHTSAPPLKRTVLDNGVVRKVGSLGNESCWEDEESIETTQRLALAALCDASKLDGTDPILWLKLACAARQLQTTIAERNSSLVLASKYRRMQKYALESGTTALPSHMPPNRAIARARKELEEEEQQQMEQDYDAPLLLTEDEEPTQITLELPRYSWSIFGRMLVRVCREGTDYQANPHGPVVLKASPAFGSPALVVKLNPMFVLPPRLLRRICAFLDTRSTVRFEMTCRGISFSMMDAMASSFEDDDNRRKMSTIFRHDETEEKSTDGIENEIGSAAKGDGTNDVPMELSSDDKQEESKEKESSSSSKDKTQSSRTSKRLRSQQITSGKIAERQSNRKSFEYCFLAATMSCTKAEFKQQVQEAKKHEARSNGHGGWSNPALNSRGSQLDTNVLLEAKERTSAASLGAFVEQYGTQSCNPIDLLRKYLGHVAMNVHDVFVTDPRGPLELTSSVLTAFDLYINRTGSKQRLALLFFEPVERTGSFKASLELFALDLLYCELVLKRCERYAPTPVNFDEDCSIVARMVLPLLEAFDALEQSMERTQHLEENLLQTFFMLGIRSKWLGAGFYFWRRRISQVVFESREAEDEAVYYIDEANKAFESPTVKFAAVATPHLVSPGRTEAHWKEVKPNLLGKLRDDIQASSVVSHAKQRFQELVGSLHKANEQADATITETSASTLTSIGEDLFERYRESHGKSGAKHMELVEDFLLVHGEDLYTLINPAEHDDDDDPVADPIPVQTVSVGNLIQMSNPSILSILTTCFNVDNEHREHSIRLLAHVALTAKDLFDESLARSVQSQGGDNMDDSHSDDDSMMSDDDSRNMGTKTRNTDELRARQCGLFVIFLIRKIKTIFLTVMDNEERKECCMSSDCTSLLVCMFALLRDWTCGGGKRWLLPDDTSDQRLFLVIVQFMEALRCSAPADRCKELERFFFVGIARTMVAQSNSLLSRVNTQGSRTGRATRQKLCIKQAELLGLVLNELGHLLSGKLVTIEDLQIRPNEIISGGAESVEKDSLKRETILFCDAVLRLWRYGSLALSSDEQGEKSTSVCSSFDRPIVRSIQTPLIVAITGLCGSAIRTATEAHSDESGVDQLCLTDFYDSDASANEWLLDCEGPEASEIRQRMRLLLRVICHTVYCINIVMTVAGDKRAVSNMSLIESRHEYGPLLPLVATRVLNFFADSLLVYFGSGNDPASRSESLWAKEYPYTTRSTGEVLDVLLRRSYRWLFGFTLVGEKENTSSTTDNLARNLQPESTSAAARLYRCIVRTYPSGRRSPPKSALEVVSSALPPIEETEKSRSLKEFVFQSNGAETGTKSVLRLMEKAESWNRPFKKIKDLLDQEQEVSEITSVAAGASSTADEAYRVRRGISSELASGQVPANLADTGQKGKSDSSSEDERLLCLKHEEEASKKFLAIIDDICLGNANDTTSWYRAAQCVALKAELIADRLGLSKGYARSNDFSAPSQPRRLKKRLTLDVLEAEQKREDLKISQNWVTVLGQDLSVYVRHSWSSFSSLQACSDEIKKSLGDRGNLDKSQKTLEMVALKNLEKMNASQKFLEWQEAWGGIFVFALKKLALRLLCTALFMVESKEKVESDDKILNSEICEAIGVALYSQMMASQNYGYPMHTMSEDRKRSIAMVAKVAFERAANGIKEDESQETWDLTFMVGKCHEKIASTFKRETFTESTRLYEKHMSLAMSSYASALEQAKAIDEDGGHVISQQGGSSHGSTEVLYRIHASRLKCLISLASYDDDCMENAEVEALRLTEAHWYKVQDEAETTNAPLGKRDRIWNVVADVVAGLAQCRMDDHFFHRSVYRHAQALMWAPVLLDPASREGSLGMVQATKSHIVRGLNNSTHAAYSAEVVIRTLFDRKRAQLCAVWLTSDASNSPFQVLNSSNRKYDSLRGKYIGAYIEALRLCNRWSELEQFTKLLCHSKRDAANYFQASALEGGNPPSKSHANDCILYKKDSALMSKGFGISAKRQANSVFAELIMKKISDTDIEKGMEVESNLKQAYACFLRLHCSDDDIKRTSAIKYGVSSIKEVEALCQAFLETEHAKTVKTDSNDWSGGAQKKSVFDEALSKCRALFPTLSGNFLFKQSSKSKDKDSTSGGKKRKRPSESAESGDPTTKQFEISVPQELAAGDQFVTTISFGENVTKKVKLTVPKGNPKTLRFSLKIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAJ7</accession>
    <name>A0AAD2GAJ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="573" mass="60537" checksum="ACC6876C494EAE74" modified="2024-05-29" version="1">MPGLGRFSKGKPQTPSGIPNIAQTTGATPEAMPEEEGNWLQFDVSGMDFDSFGGDNNDAASFGYLDTNAQDDEEEEQVLPLPANAATNQATSTKGLGLSMFKNKASNSTATNELPTATTATDNTEDTVMQTNTTEPNAAAASEENDLQNPVATGYAQEHQDQDTLMTESHDSSLAALHPAEQANDTSNSLGGSSTGLAMFASAGGNARAPAAARVGQQQTANSGNANSARPEFSLLARASTDNVTGGNEKTSEGSTPSNARTIPNFTPTATEAGTAQVLPPMGAPTRVLPLPAKMAPPLVPPTNQQARQGVIPQFAANRSIPQEGQTTPKQPLRIARQSNAMAKTTPHQTQMPRPANHLQTPRTINRQQQMNANPAAGLVLKHHHAPFSAVTPSPTNTNRPNPMRRNNNNNNNNNNNNNNNKMKNVVLPSSKPRASPHPNQQGNGTVVPPPAAATQAPATQAATPAPATQAAAAAATTTTQAATTDDNDSSPPPPDSTPDFNDLHAQFLSDIRDLEDTQDVNADRLLSMESNLAIAYSVLLQDQFQFLHLLDKLEHVTHETDQAITKYHHQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCY4</accession>
    <name>A0AAD2GCY4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS23545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCY4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1969118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="437" mass="48911" checksum="206CC84527EC7188" modified="2024-05-29" version="1">MIHVERPLGRALVRAATAPSISRMPRVCWKMEQRGFPLHNPWNGRRYLLSQAVTRRLDTMVARHVELLKQMEENPEESYTYGKELASLAQAVSLHERKEAILAEEKSIQELLEECGDDEDMKKECMETLEQCKEDMEALNRKMRTAVLPKDEDDTRSNAIIEIRAGTGGDEAGLFASELRDTYEKTAKAMNFSCETLSESRTDIGGIKETVISVSARGFGGAGADLDADDDDDFQSSVGPYGFLRYESGVHRVQRVPVNDTRIHTSACSVAVLPLLEESGNAEELLPMSELKIETMRSSGAGGQHVNTTDSAVRITHIPTGITASIQDQRSQHKNKDKALKLIAARVRDLQREEESQKRGAARSSLMGGGDRSERIRTYNYPQDRITDHRCKHSTHGISKILEGGSDDGLVSTFFPLLRDMVREEKMTELEEEELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGW7</accession>
    <name>A0AAD2JGW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGW7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="391"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="464"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="547" mass="61508" checksum="0CEC3EFE4032194F" modified="2024-05-29" version="1">MHHKLIGGDLDSGYQYSQNGRRRRIQPVSSNRMLGGFGNYYESGTDDEDERNMTHVGYDHIPLTPGLSHAVRLELGTDPMVLGPERKISDADCDSEDDDSASRSSSSESSAPSTGLRNRDDDDDDDDDEPMEIRPLYKEEPTTTITEDQATPNLFFQQTKKAPTMLYNTTRSKDVLQLKLAMQKQTEFDDLYRDMDHRDHCFSTPAKASIPTFEPTPPTTTTIPTTTNRTTIPNRKRSRSNSRSNSPVPQFIAVSPEVLGATEPARRLKSPPPGASPSVAGGGGGGVATATAAAAASATSAANTPNTSSVLLKSTYVRRPHKNKRKSKSEMATTTSTASAGKLEKQTSTKKKASPPNKKPSPPKQQQPQEQQQQHQLEDSEEDSRFKRFQNTQWNKKFQELLIFRKENGHCQVPHTWPPNPQLARWVKRQRYQFKLRCEGKLSTMTEDRISLLDDAGFVWDSHAAAWQEKYEELKDYVKKNKTFNMGSSYSTHPQLATWVKCQRRQYKLLMAGEESNMTHERKDLLEKLGFLWDVRKSGHSGTPKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH82</accession>
    <name>A0AAD2JH82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="66"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="392" mass="41008" checksum="B3EFA08F3838A2EB" modified="2024-05-29" version="1">MNSIPGFASLPQKSPDDDERSSSSDGTVEEPTETEQRYAALRNHQIRFADAIDPNAERVHKLRKKDIIFGRGRGFQNHPGNERMRDIIEKYKTQYHSLNRDGKRKLVEAVHAEITEGGARFLKKLDNEQAWVVVDLPIALQKVSHTMRCRKSIIRQLDEHGNIPGALSTPHLAANLPGMTPLAPMPMSGHLPGMGAIAGMSGFSDPAAGILGGPGAGLPSLGAHGMYAPPGAGAAAAAGDAPLAALEAQRMAALHRYRVLSGMAVARQGDIEYYQHLRREQLLRETRMLQQMGDVALLGGGSPPPTAAGSIVAPSAPTSSLAAVTATAGPSSSSALGVSNAPAAAAGRHIAPPPGARLQPSTLPASASSNLSESSASDIFADAVKDPSAHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI39</accession>
    <name>A0AAD2JI39_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001821">
        <property type="protein sequence ID" value="CAJ1953157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="148" mass="16425" checksum="3E650E6D2C9E29DE" modified="2024-05-29" version="1">MGTLPGDVQQASVNLHPRTAYVTVTGTAPVDLPDQESLPASILHIWRELAANMDDNWGWVPESIYIEGDEQVLLEALEKGKLWVISNGSFKQQVGTAAVQLRTRPGGHVIWIKCRTPGKREDQSAYRSELIGLLASWLRLRLQSLAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJJ0</accession>
    <name>A0AAD2JJJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40866">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40866:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="596" mass="67917" checksum="99E70E1B6F854737" modified="2024-05-29" version="1">MANIPVKKKSPKADAIRSSESSTGVRRSRRRKHIMYIQQRDEQEDQAKSSPTKVQSTNKPSTGNRSRSTTTTKIQSTPNDPERQKREEIRHMSRWIEMIIKEGWPLSSVDDEAYRDKIGLSSDITLQQNQVAEVILAMNQLVMKKIGSEMKAARRGAILHSEGIESSRYIVGIVASYMVGPKVTQTLLALGEVHELRSVVKRCSTRQDTTMTADSIAEKHARYIQQQVFSDRYDFNSRELQKWLVCQTAITCNAITKVASLLGIPHVDCQSQLLDKQVKQMLERTKGTTFGVGQLISEVREVIKTAQESKYSSDELRNFLRILDDKEEGWSSGATMIAKFHAKKSDILKAVQHEDEKIIVRCNSLINSDRATKQAQKMLQNLKFIQRRLTTKGHPLSSCREDIQSLLDYADAHSHDIESQWFDHKLGTKYIHPLSKKLKDVNFISGVCKIQRKKFALLNDVETTACQQLKRPTMAASPVGRADDFKAFVCRKERQASLPSRDNISLRSIYHLEEEYSDCDFIIGSSSEMEKVWSDARQHKAAQDDTISVALFEAIMMLRYNWRLWDASTVGDAVEYVKSNTSDEQGQKSKKRRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL20</accession>
    <name>A0AAD2JL20_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002049">
        <property type="protein sequence ID" value="CAJ1960184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="338" mass="37563" checksum="1A65CC66BF3AF93D" modified="2024-05-29" version="1">MALTKRLTGDLLHLQRRPAGWISNDAKSCFDRIVHWVAIISLMRFGIQWRTLRSMFDTLMKSKHWVRTGFGNSDRVFTPPTLIPFQGCGKGNRAGPPIWVAISSILLGMMISKGFGFPFSNPQEPGPPPLYGPSPTSQPPAPPSSILDLWHHFGSLAESGSHGWVSEVITIEGSEDRLVQALRAGTLCAVSDGSYKAKVGTVCAQILTDDRRDIIWITCQTPGKFDDQSSTCSELIDLMASLLVLDWMSQVAHLKLFASQPSVEMACDGLVALDKSFSKFHLSLSGAQFDLASTIRALLRHLPLQVHRRHVKGHLDKHRPFSQLDWWEQRNVEVDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLE9</accession>
    <name>A0AAD2JLE9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002083">
        <property type="protein sequence ID" value="CAJ1961139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLE9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="224" mass="25817" checksum="8C21E21BFA3A2520" modified="2024-05-29" version="1">MVAGQEIKFRALTIIDLVTNLFEIVRIKDKTCANVTLQFENAWLARYPRPATVIHDQGTEFDFQNHLNLHRIEPRSISAKNPQANAFCKRMHQTIGNSLRVLVTLNHPFNINDAEQLVDTAIANAVYAHRCSYHGTITATPRSLPFHRDMILDLPMEADLQLIQQHRQQLIDKELIQANRRRFAYDYQPGQEVLKFCYKPNKLDPRADGPYCIERVHSNGTLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMP5</accession>
    <name>A0AAD2JMP5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="230" mass="26410" checksum="1FCCBB876BB2CB3E" modified="2024-05-29" version="1">MNTIRSSSVMEDPPSFLRELLTEHHHQQPLDPADHQIAQQLYRRMNNDVALQKGWSADQHDHYSGAHHQHHHQSSSSLISQVLRSIRDDGDCNSKNTPNPYNDARRILLIQQQRLKAPPTGDHPNLQCQHDDDAGLDDSNFCLEPSSFSSESWQNMPERSLNDEAQDQRSIYDHLAEHRERMNVFSTLQALRGEASMANKSAWDADAFDRCVIPEEQDHDADDLIFEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNR2</accession>
    <name>A0AAD2JNR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial splicing suppressor 51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47570">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47570:SF1">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="2">
        <location>
            <begin position="414"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="618" mass="69241" checksum="0423A4DBEF139D63" modified="2024-05-29" version="1">MVRVILIPHDESKDIEAHSITVDNTGSIVASIKQLIHDRDYLETPLLRPRNETAGLYAYFNNPTDAGEEKSQLANVRATRLAMACGLLSLRFFGNVLLVRGFGFRWEDLSLNEIDGATVISPDLRDCIQKEVVSIKHNTNMSSERIAKWLADAAQNNYHDKAALAKVARAMDTEYVDEDDDDDDDDDEIDSDEKGEKDINSDDGGQKVADPSTAANTGESTTEFIAKSPLCLHCRSKLAPILCADCDGAYFCCTEEKNCRKTGWSHSCLCPTWKVYTSHREELSHFPFFGEWQKELTTRPFQTQEKPYAIFLRSSLGIQEDCSSWWTTETYGWGGGESDSAKKVNASLRKSYAEGFHPIQEIPPERQISNEDAQRANLTRNSLGFVNLTSWEDYYLLRGISTKTSPVALLCTFPLTVYYSILKYGEVPVTVARMLKRRLRIHLVGAEKEMNFLDLFKEVIYLLPTDIELELVFVVRQDMLPSNCGKRADGSYSLQIDLAPGLTIFITSGTYGDSLDPKFDCGSGAPDMVLALNAGLYAYESWRSVVTFLYENTGVVGVFSDYNEYSGVNCASMGGSKSRDSLCINPFRQPLAMPVYSMNLPQFSNGFLYAFNKQDLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNW0</accession>
    <name>A0AAD2JNW0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNW0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="507" mass="56009" checksum="7CB62E16110E5838" modified="2024-05-29" version="1">MAAIQKKNEAVASLATTTRTIVSLDDEKENQRSPAGTECVDQLEEFNEDDGSPSNGYAEDDDGYGEEGELELSGGTRSSNLPLGQHKVMKKRRSLGTLVVDSSEFKTTANRPHRRNSGSSRSRSSRGRSSESHDNDHDHDGDSDDDTQQTSSSRSLSRSARKRSSIYVMTAMRNDSPGRKTSRTSTADRPPAHPGRTTRRRSSMESKPVSKLEDFLRKDDFEKNMAPGNVNDHQISMPLRQVSRRQLTCLSDHSKDILAEQEHMESVQEVYASAEEDLSSSPASSSDMTVKVKHGSPPSTRVRKKCKASPNNAGFRKVVPSSPSWKHKNKTTGKRDEAKNTKRKSDSKERVLEQLEEAIDISKSEEFSEKETQTPSEEKEDHTNSSSQGSSMLGDTVERFLKLNDDDDGGDDGDDSLMKSAEFFDDSEPLSVTMRSMTDYSDDLTDSGDTKSPVITRSKKISVKKESSKTTTTIKSLGRLFGRGLFKRTKRGKGAGSEEEVTPVAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPB3</accession>
    <name>A0AAD2JPB3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPB3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15440" checksum="150247D8EABF50C7" modified="2024-05-29" version="1">MAGPTPLNKKTIVKKRSKKFARHQSDQFIRIRDSSWRKPKGIDGRVRRRFKGAVPMPSIGYGSDKQTRNIHPHGFKTVVVNNVSELEMLMMHNRTYAATVASSVSSRVRKEIVQRAEQLAIRVTNANAKLRAEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPI5</accession>
    <name>A0AAD2JPI5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS23833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042064231" description="Glycosyl transferase family 25 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="3">
        <location>
            <begin position="29"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1969674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="339" mass="38883" checksum="1EB60C1219F9674B" modified="2024-05-29" version="1">MKKCSTLLQTLAVILSLLIPSTNGQRFNVINLARDTDRWERVKVELMKEFDLEKIHRMEGVHGKSLTSQERHENASLGARLFCTEGTIGCYMSHRKFWEQVVEGDEPYQIVFEDDVVLTDDFQEQVKARIEELKGAVGAENWDVLMLGALGCVNPNPRKYGSYVIPAFVSGGCRKPRKITENIHIPMRPFGTHAYILSKRGAKKLLDRSWRATYHVDCVIWGMRDLDLYIAHPLLVYQDSSPSTVGAITSGPETWIPSSIQMDDYTKMRLEWVWNEAVIRIPAINLIITQGRYLLIGIFGSIFGAFRHKKAPKFLPKFLSMYFIFIVSFNRIINRPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPJ7</accession>
    <name>A0AAD2JPJ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042245797" evidence="1">
        <location>
            <begin position="22"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="528" mass="59916" checksum="2C3A9D672FF754F1" modified="2024-05-29" version="1">MTIHYFGIPFLAIVWDTSVNAFKTQTWDVGGIRRRRSVLLSELFYLLKKFVDHRIGHDVENYGIGDAWPTNASVTLLACLKEPRVLPETGIPTMLDPIRAKFNSAGLLRFDFLHGDFIRWLGGEYVNSARDFNAEWDVIDSTLHNREVPAEYPPLKLEMAYRIQTEGVPIKAKYTTPMSATVLREEYDNHPAVAANFSKVEEKFAKEEWKAYHLHYLRFVFQFIPGLVINPIQWVFDKGKGRICIDCSNGPDDLGSINTYIPKPKQDETGDECPPIHYQFAFKRFLCQILRMRITEPTSPILVHADDVEAAFCRVLYHPDVAVAFAYVFSDYLIVPVGQVFGSRNAPSFYCVLADLREVLAMCRVDVPMDELHDLVQKCSISVDTTTPLCTVPADSHHPPLSMDELLRIYNASYGDDNAVAAFAAHIEQAIHHSVMSAFEVFGHDPRQGDCLQATKWEPEVTETFLFLGFCINTHDMTVSWPLYKREDLHSQLVDILSVVPVVSLLEKWRGLLALSDPHLKLLHGAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JQH7</accession>
    <name>A0AAD2JQH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tropomodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS24481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002524">
        <property type="protein sequence ID" value="CAJ1970465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JQH7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF6">
        <property type="entry name" value="TROPOMODULIN, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1970465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57311" checksum="E68130844798DEA0" modified="2024-05-29" version="1">MPSLKERMAAFQDASSPDKFQEEKRATTPKAMPRARSRSPPPNFLTNSGGKKKPVRGKVVENHVSPVRQRPKDWDYLFDLANRFDQFKAEEADQKKKKAAGELPPTPEKEANEEEGGGTDIRAALEGVMAGSYTASADWLNQDWITEHLVESTGENYKSLTFNFNDPSLFKKFTKVQDKDRKVIIAKFISNLLSHPKSGEITRLDLHGALLPDEFMEELSVEILKKPTSTLKNLQVLNLESNLLQGKGIEALAKMIRHDLSLRYLQVLQLENQGKTMTSDAESALATAIGHSNSLVVCSLRVRGAMEKKEIDDITAYNMDHLRQARREHAAKSGTLKTRKRNEMEQYFDKIAANDASITAVDIVGDQKFLTLKAAEKVKSGAAFATNTNIKTLKMQKLGLDDDFAKQLGESLAKNSTLEKVVIDSNAITGAGIKALFAGLGQNSTIVEFQVRHQSKTMASTDEQPLPELLEPNKSIIKLGVDCRDQLIKMKLDKVTNNNREHQRKLRAAAKKAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU29</accession>
    <name>A0AAD2PU29_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="166" mass="19124" checksum="0ED28DB1F4F81D95" modified="2024-05-29" version="1">MCGPTESLSTADLKGPKEKADIYLSCDEPSIEFAETLKKEIESRCNLSVALDRDDSWEEDSNDCAFLEHMHQAKVMVPIVTEHVNITAWIMDYRPARGLTAQQALAHRLHYQRCCKPPAINFSKSYKEGLREFMDIVKRNTGSRRFRKPNKVLNRINTVVRKVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV99</accession>
    <name>A0AAD2PV99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS15035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1954443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="880" mass="97460" checksum="406EF4E76F6C92E2" modified="2024-05-29" version="1">MSIPAKKGNAVVWNPHNPASLLVPTVRGESDGAFATNTFLSHDGVGCNDHERTAVMDLLDAQDAYLQSPTGPQALLSLSKSYRRALSNCLQGWEDELLSSEQQDDAADAQDGSISSNLENLELLKVAYAVTHLSETFLLLPANDQVMDFYESTTNLPGAVTAETVRYLRLHHMTEASDFLDEETLDNLFQSIQPDQWEGTGAVYWQLLEKYVVRGNLEDAWGLLTRHSLCRRCTEAIAAAASNSSSNVLAGLDEYTAASLQEDREGLEALRAILLSAPLPGGRTDQFDAVLADDDDYRKHGGDDGQEFDEDDPNNCYIEGIPLSAYRLWETSSKRRGKGDMPSAYNDQYSKQVYRSWQQSIRSLPALDKLCRRMPSLRKILDILNGDFSKVQFDSWAEQFCAELLYKAPDLRLVDMNIRAMRVIEQHNKNDSQMMSDESGGGMSEFEEVVLSVMKGNAGRVIEVMHQLGGGSGAALPAVMTSLLCNLLHDAEILPEVSTSYSLKTELLLNAAFAIHSSLATEGHSDVATRLTARFLVPHIKVRGDIRIAATLVETLEHHYPKSDAEANALLALCRSLVERKNVRVLDGCVSICLARYRYYLKDQRPGGAFHWLLVGMEFESLILSTRNDSSKMMIDSSENAIDTNWQRAQETGVCHRLLVNYCLETTRGLLKEMLGEGEEGFAILHGRAKEMIATAVEETDFSTFIRSARALENMLLIANAIAEDKGDRIVADNIVALLEERADEEENGVVSSLARFSMHWDILKLAKGVLRRDADLQSGVGNQKGFKSSFDVNGMKVLLERFTVISAAKDMEKAPLVPEETKGMRLALGEGLMRALVVENATKRIHMEASKTSISGIYSSDLGKHSREKQELVVARMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW02</accession>
    <name>A0AAD2PW02_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042030221" description="HEAT repeat-containing protein 1" evidence="3">
        <location>
            <begin position="25"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1958500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1405" mass="154306" checksum="7398427C413D864E" modified="2024-05-29" version="1">MNIFGAKAFLILVFYFQSFPFGQSASPTISRSWKAWRGWMIRNTGATYRVRQYKDLKDGEFPNTVRTTVRGGGSSHNNVEVEEHLKVDQATSSPLEIPEATNQKDSTTILTLTRKGHRCTQDVILDLLRRSSIDLKLESIELLQLITTRSSDYLQDLKLAVEEENKKLPHPRKLLHFLAPKIPAIKHSPDVNLRVHSSRSDIDSSIAACIIGTLAHVSEIYDKQTIMRASSTEESHSVGPELTTDRRFEQLVECVLNGVNIQKRKKESLNRQLEKNSDAVADIEQVLDEEDAHIDDGLNVRDACRAAWGISVLGCSHLETIADVKILDLLLALSLRVRELLLARLQLIRQDDLFSGPSNAHITTSERLNQVVEELAEDAATAMWAFACVKACTGLRSVPLFETCCSILCQDPIDMRKRAQSADYEPGLPIGVHDVVDRLADAENVDQAPENEIDSSKNETAYARSEDTGNGKDAFLDWLSPTEVNDVLWAIALHGSNNTSASDEITLSETASALGEIAFDRLLEWLEHDSLLSLEDVDGKSPSSIKIKSDKDEVTVEVVDAASLLASNMEPSDPFESTGEILPAENSTFSNQKNVEEIEVVDAAALLASASAPGKEMIEKETITASASVTGTNSIEALSSEGVARPRGYKSSPIFTPHDLASMAWSVTELRDPLQVRIVGIVVRLIERLGLDGTKRLGGGDLANLAWAISKSSDISTKPHSNGRILASFSVLSWISHSALQWVTKGQSSDCEKSVQILESFQPPELGRLAWAMANIASTNSMHSQTLKRNTEVMELARLSLEAAASNPELFATEDMLRIAWSFLELCSDDDSMITLSVADALGSILAAVEQSLHQWERGKTSITQYETRDASVFSSFFGLPRLKQQLLEHALNDGEDEDESTLTPILEKSRKPLLRDLTVDPATLCKAACGYQRLSKKYPSMKGAWSLTRVAIRLLASKNARLMKECSIHDVISLCEATVLAEGDGHRTDLVTGLFARKVLQLLNVAVDNGTEANDSSIDVTQASSTEICTLLWSLGELGVKHRFNDDAKCSAYKRRHFVCESALLSPSEVEDLPLPSILKLLRGTVIMNYLATDKVFLLNILKAILTKGSMLKSHDLCYVAESIALLKEALTPGHLYDASRSSGNPPSSEILKSEKVGKRGEEHSDATTGETEYLGEESPPQIGEASIEQDLQQSCDAILACIGTVARKDAAILQTKVIRRLLAVYSLLPFQDDALIESLSSIVALRKLHLEQLPQESLGSLLRTARSSAESVKDTVFGSLESGSVFEQLKHGFRSFFSSIQETEAKENGDDILTEELLTSVQESIDRASKASKSAEDLQAALGVSLDSIFSSMKRGTAFELAQCEELIDNYYRINFVTGTFKSRYDKVGARDIAKRVLGRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWG9</accession>
    <name>A0AAD2PWG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS18850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053213">
        <property type="entry name" value="RLP29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48009">
        <property type="entry name" value="LEUCINE-RICH REPEAT (LRR) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48009:SF4">
        <property type="entry name" value="LEUCINE-RICH REPEAT (LRR) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1960700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="54774" checksum="2C733E252A07B832" modified="2024-05-29" version="1">MDNDAPFDERPAAPVANSKVESRDVEMDHGLPIDEQPAPPVNNAKPKDHSIMDTIIVHKVTPDVAQERRKLPQQVSSARETRTIEDQTHPPEPLEAEQQQQQRSNEEEKEVETTDNSRICNGKKRWILIALVVIVIVAILGGALGGSSSTRAALGFPTEAPTSFPTGSPSQAPTFPPSETPSQAPTTLRSKVEGILRDYEPLDEQTMDWLLETSTWEPDPGDPNGDYLWLERYAMAFLYFSTNGPNWAIINSNINNNWLSDEAACTWFSLEPTLDCPGPVTSLVLKLIGLQGSLPSALFGLSALTKLDLARNQLTESSIPDTIQNLQNLTFLDLASTGLSGSIPATIQSLTNLEYLYLNGNSLTGFMPGHRRMTNLRVLSYWGNQLTGPIPRFGNNMTNLVDLQLYGNRLDGNIPASIGNLNSLTRLSLNTNRLTGSIPETVVQLSNLEWLSLYENFLQGPVPKLPDNPNIEFNCFLGQCYSNLTNAVAARCIIYNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXH0</accession>
    <name>A0AAD2PXH0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="GLCNAC TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496:SF6">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1219" mass="139838" checksum="67F6BE0A27F440F0" modified="2024-05-29" version="1">MQASNELSTYHYHGQEGENVPDDVETLIVDACVSVLPDHFCSFRSELKEVHLAEGLREIGTAAFYECVNLKDIEFPSTLETIGERAFLYCFALTRVHFTEPSSSFQRIKERAFTGVPLRKFTSPSSMRILDRHVFADCYSLLEVNLGFSRLCEIPSFAFEQADNLQAVRLPSSVKRIACYAFYDCPNLVTVEVISSPNRHPICVEKKSFFNCKSLANIRIFTAHGKVDEAAFDGCILLHEYCGTRHDEIIHGQARRFDEHPIHHLCYHSSTTTVEELRRCINSQGNLSLLVTDNFDMTPFHILCSSVEPRQDLFLVLLDNGKCPAHYNVLGWKDTNGKRAMDYLITNWSPETANLFRVAMQRWIIGSWERWGATAGLEDMEGRIEAILDRSVDKDLRQSLFNDTCSAFEYYAIIETMSLLELAIWKQKNLEVGESRREECRLLCQTDMVLANVDSKQQQQEKEEEEQGQVVDGATDDGNNQEVDPIKQAADEAKAKEEEEEEIKEEEEKVLDKDTKEAEDLEGAEKEEGTSDEEQKLEHALKAEEEIKAMDQLTSEEQKKIAQRLQKQLNFNRDHPYGVTLLARDNQNNRRLFPNGPFGTIDVAESDCQDGVCPHYSEQPDAKLENAKHTPVHMLIAAFRDKLCSRTLHYAFTQAENPSRLFIRVIDQVQPGSDLEDDAGCWELYCEKYNHNCNEYKSQVRIVKIDSAQSMGPTYARSKLSAMVHWDYINRDKSEEIDLQVVNEQDYCMQIDSHMNFSKRFDTRLIEMHHRTKNDYAVLSTYVTDIENNDQDEKTVPNLCMVTFTSSIRNWGTKECKYLVRPKLTNAMWGAGLSFHRCHGELVVPVDPYLDNVFDGEEGSRGIRFFTHGYDVYAPDIVLVTHDYKTHQGNPVVHTWGRGARQHQDEDEDLKVGEKKWKWMEEINKHRPELTVFGTDRVNMLLGIGSHHNSTEREQKELDLIRNSRFGLGTKRTMEQVKEFTGIDLLNKKMESNKCGNNYWVPFEESPNYGVQEVLARGNVGKVQEPPKPEEIKTKEVAKEKKGAAPPKHVVVAEEQEEKKKEEEEEPVADQLEHELLEEDQVLKNALKQKTVKKSKKKKPLGDLLSEPNHDIVKRKKIRGAGAVLPEDSSPDLHSNRFERAKHLLDNAKPQMRHAAELLKTKEEALMAGAVRLKEKEQEMISNGQVDYQFFGIVSLIIVLLLFIMSTQGKKRRDHKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXP8</accession>
    <name>A0AAD2PXP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF10">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1365"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1395"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="714"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1661"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1668"/>
            <end position="1684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1967204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1691" mass="186101" checksum="C492D3926B99A23D" modified="2024-05-29" version="1">MSIPTTLETEESSSSSRLLNSAQTAASKPEMAESPLVKACSHLLKTNGSIIGDEVAEAILPLFPDLISALPCHQEVFAQRQALLGIDSSKRTLHHKRIREFIADELGPQLHQMGLGKGDRIALVLPNGPELALAILGVAQWASCLPLNANGAVSELKKDLTLANASVVVGMAGETSIQELAASLNIPFCGLQPSTTETAIFQLIPSSSSLKKTTTQSNIASTTSRFAPNSHDDEVLVLFTSGTTGNKKLVPHKLGDMLIAAGCIAVSWNLTPTDVNCNLMPLFHVGGIVRQVFAPILSAGSVICCPSFDPQLFWQLLLGNDTFFSWYYAAPTMHQVLLETMPSDATPKLRMIANAAGGLLPSLAQRMRNTYRGTNVLPSYGMTECMPISSPPHNYELTKPGTSGVAVGPEISIFNANEEPLEPGKEGSICVRGRPCFHGYGGQAKSKSFAKGGWFNTGDLGYLDQDGYLYITGRSKEVINRGGEIISPMEVEEEVVSHPSVVACAAFSATHDVLQEVVGIVIVPKPNAPKIDLPTLHDYLQTRLATAKWPHAMVFMDALPKSHTNKLLRVKLGQRLGLPEMNDKMLPVQRTFEAKCPKQGTPVGTPIASKEVTVDAQHVQNALHQALRINEKQLVVKNHPNRYGSLVVHATNNDLTSKAIIEAGKASLDAYLRPSHVCIYNDSDEGKEGLTSLRAPQSADAVGFIEMMENAGDAISDPMIEELQKSMQGLISLDYLPPPDTSFFQVGGTSLLASQMASRIRKDYQIPFSGADVFRYNNCIAMAKMIKSKQSPSAASTDSSSTAQYSVHLDAISLDSERLQPENSIATLVYQLLPGCIVFPLWYFTRFFLFFMTLLEVLNRVPGSRNMSRFIGILVGYHFLWNVLSPLVFVLIKWTLIGEYKPGKHAFWSSYYIRWWFVDTCRKMFGKGFWGSSQFLLIIFYKLLGAKIAWDARISIEADIAEYDLVTIGKDASIEYATVRGFGVDNGAMLLGTVKVGNSASVGIRSIVAPNTQVPDGAHVAPGTCSYEIAKDSLKHLAYNRYALPEPNLLWQLLVGSPVTFLVDSFSHLPAMFVLFEMMIAHSSQWEEEHYRFETIGDLLEWLCDPERIPYYLGIRIVRATVAPFLYMVGALFVKWAIIGEFKEGPRDSTSQWDRMRHSLVSTLFSRENIQNVTDLLGRHYELTSIFYRLLGAKVGKRVFWPGHQPVFGGEFDLLEIGDDVVFGSRSVVYTSTTHSCEKVVFCAGANISDNTIVLPGSIIGKNAVLGSNTTCPAGRYLPPETTWVGSRAGEPILLDTTGDDGNDGVLYSANVKQSDLEMIGDETTLRPFGRAVYGGKANYLILPGWSMALISIAYEALTTCFHALPLLGATFLTAGIVYGWPVEDRDYDEYLHTLIVSHIIFSIFTALHIARIVVGLMIEIGAKWLLLGRRIEGRYNWDECGYNQNWELYQLLGRVRKLHRISTLDFLAGTPLMVQYFRALGSSIGKGCCLYPAGADPYMPEPDLVTIGDNVCIDMASVVCHLNTRGNFELVPIVLQSNTTLRSRSRAQQGVVVEEGAMLLEKSLVLTGEVVESESIWQGAPASQILLPKSHPRKSIEKSKKREDGWVLTNRRLFEIVFLSLALTAGVTLLPTPTNQYLSGNFLNWQQHPRGNQAKWYRAVKQEVKTNKPKKKKKKRKRSKKKSQAGGDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAX6</accession>
    <name>A0AAD2CAX6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1910140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042038629" description="Rieske domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1910140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="20977" checksum="FA22A4ECCA829881" modified="2024-05-29" version="1">MILPKFLTLALLALQLMASQVEGFQLVMMGRKAGKGNLKQQLSGEGVSKKKGNSINAVNQGRGQEITGVTLPAEGGLKGWEFGEGKQMACANVDGNFYAVQGDCPRCGFDLWRGEVIANDPGWEELPRVACPTCATTYSLSSGKRGPPIKRTGLAGFVGKLAKTATATEQTRDAEAFQISLDEEGRVYCRSKSKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBW1</accession>
    <name>A0AAD2CBW1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000014">
        <property type="protein sequence ID" value="CAJ1927084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBW1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1927084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="213" mass="23791" checksum="60244423EBEFC451" modified="2024-05-29" version="1">MNFKTIIEQNDETLAFLRTRDYSKAAVASSTALKCLRSLQEQCAGASKGCCNELYSSTCSDGLDQCMLLSKVEDESSFEANDEFIYKHGISLHSEVIGAEIITSVLLFNTALAHHMLAIEQQQHQALLKAKRLYELAYSAYEMDHNILFQFAVINNIVVIDRKLGNEVMPNECLAHLISLFMVFVDQGCNMHLRHVQGFLVNLPWAIDAAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC45</accession>
    <name>A0AAD2CC45_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CC45"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="509"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1926366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="601" mass="67444" checksum="CA688A8D5880E373" modified="2024-05-29" version="1">MESFPYSHNNVAVTHRDHGALFHPSSSVATPSLAKYVVANDDIPLAGPQHGRSNGNKNNDMKPLEDFVASEFCKLSVEEQTKALSDLYCQSAAADKKQEDTNLSNSSSCDLNENPVMIQDSLRRFELQIQQGNFPIYDIALVQNRSYVQDPTFRLKFLRANRHNVPKAVHQMTCFLQEKAVHFGQDKVAREITLDDLSPEELDLMISDRYHIQGGRDQKGRVIHYSFPAALGGGGVGVRGTSSCPSVGMVNRVNYYVWFNILSNMAVVQSKGLVAVHYDTAQPDAASSNKPSFDFIHKSMAFFATMPIRYSAIHLCFPESAAAKRDASIKNLVLGAYLRSIPLYSRARTTMHHGSDWEIQYRLIQQYGFPHAGTFPVDSQGKIRRNVLNVWLHLHMANEPSYIDSFNCTMVQLEDDDDEDDRDDYSITSEEDEICTVATDVAVVLDPPPAATVAKYTYAASASGGRINNDVLHQISIASSSSSSQNTPATITEQQQQKGGGGQHRPDHDVFFGRGRGIQDHPGNIRCREYLQEYHHAYDTAPRNQRGKVTKALTNALRQQGTRFYERNQNREWVEAEPKVIEKKIGQLLREFRKKKNQNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC83</accession>
    <name>A0AAD2CC83_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000032">
        <property type="protein sequence ID" value="CAJ1928058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CC83"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="112" mass="12765" checksum="1435AD56E0B62770" modified="2024-05-29" version="1">MRAAVKPDGEEYYEYILCYVDDILCMSMKAKEVMEGIGKLFKFKKRKIELPESYLGARLDGVDMWTMSSYDYVVAAVKNVKETLKGNTKWKLPKNAPTPMTSAYEPEMDGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCW6</accession>
    <name>A0AAD2CCW6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS1340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000025">
        <property type="protein sequence ID" value="CAJ1927708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCW6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000091">
        <property type="entry name" value="Zinc finger CCHC-type-containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042246">
        <property type="entry name" value="ZCCHC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1927708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="200" mass="22402" checksum="638B160F2F5F3F27" modified="2024-05-29" version="1">MGESNQRNSNKGSTLKKPKMTKEERRAKYTALARKRRDKQKEQRGVHNQRFGHNKQIVCFQCRKSGHTVATCPLNAGNEAVDKCTKVLCYKCGSTKHSLSECTHRDSSKELPYAKCFICGEMGHLSSHCSKNKKGIYVNGGSCRYCGSTEHLATDCNDKKKKKTVDPVGETDINDLLEKPKDAHASAAPPKKKKQRVVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD98</accession>
    <name>A0AAD2CD98_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000068">
        <property type="protein sequence ID" value="CAJ1928941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="336" mass="37720" checksum="0BA79131BB6D0A11" modified="2024-05-29" version="1">MAESGSHGWVPEVITIEGSEDCLVQALLDGTLRAVSDGSYKAKVGTACAQILTEDRRDIIWITCQTPGKFEDQNSTRSKLIGLMASLLVLEWMAQLAQLKLFASQPSVEMACDRLIALDKCFSETHLSLSGAQFDLASTIRALLCHLPLQVHRRHVKGRLDKHRPFSQLDWWEQRNVEVDSKAQSYRRLLETTGQSGASNPRFFHEPVALFIDRIKSSRLDQAHIMELVSLPALRAYWSSKDRLSEQSIRKHITDALIVLKLSQVSRLPLTAVMGIYHTEVSPVLLNQFEASNPREVALSHITLHPCTCRTDLATRGGVFLFCFLRFLKVVVGMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE57</accession>
    <name>A0AAD2CE57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS2520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040000178">
        <property type="protein sequence ID" value="CAJ1931731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE57"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="436"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="617"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1931731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1026" mass="114972" checksum="AAD87182367CA6C8" modified="2024-05-29" version="1">MKKAKKKVSELTPVERMEDLALVAKVSEALSPHIGGLTDKTLSEYVIHLTEKQLKQNQKSAGLESEIAQSQGLRQRLADNGAPAIPLSLCKKLLLWTSEQSPRLKRRRAKQAEKVFSSQKRDGLNENVLGSSFPALAKSNLGHSVPLETDFYERASMARSSGERTARGISNLPAWMTKGKSQEPLAKKRRTGNDDHDDDGQKSQQSKSRILSGRSTAAAMSSTAVVHPGLDIKALTKCDNNRMKAARSNKQGLSEQELFDAQQLVRSGVLPVEQYPTYDANIGMLAVEETEEETEVELNTDHEAAFLRGQTKKSGRRDLEPIKIVKNPDGSLQRAAMQQNAQAKERRELRQAQANQLIDSIPKDLNRPWEDPLPEAGERHFAQELRSINVMSQMDGAPEWKQKIENKTLSYGIISNKSIKEQREGLPICQLKTELLSAISENQVLVVIGETGSGKTTQMTQYMVELGLAKRGIIGCTQPRRVAAVSVAKRVAEEFGCALGENVGYSIRFEDVTSSETIIKYMTDGMLMREYLADNDLKRYSALMLDEAHERTIHTDVLFGLLKDLCRRRPDMKIIVTSATLDAEKFSSYFFQCPIFTIPGRTFPVEILYAKEPESDYLDAAMITVMQIHLSEPVGDILVFLTGQEEIDTCCETLFTRMQSLGDLAPELIVLPVYSALPAEMQSRIFEPAPPGSRKCIVATNIAEASLTIDGIYYVVDPGFSKQKAFNPKLGMDSLVVTPISQASARQRAGRAGRTGPGKCYRLYTEHAFKTEMMSTNIPEIQRTNLGNVVLQLKAMGINDLIGFDFMDPPPVATLVGALESLHALGALDEEGLLTRLGRKMAEFPLEPNLSKMLILSVDLGCSEEILTITAMLSVENPFYRPKDKQAQADMKKAKFHQPEGDHLTLLTVYKGWESSRFSNPWCFENFVQARSMKRAQDTTRLYRKQLPLVSSQMQPRKIHKKDIVHLSIRTLYISIHRRHSSTKHPTFYKLADPNKITKQKRKEKIEPLFDRFNPKDSWRLSKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF95</accession>
    <name>A0AAD2CF95_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000235">
        <property type="protein sequence ID" value="CAJ1933016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF95"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="153" mass="17555" checksum="BC2F69AF5C57ED60" modified="2024-05-29" version="1" fragment="single">MLNNTVTDATSSDEERDEESAMYNGKPQDGQEPLHILVTDLQEKMFTMETKLKRYEDQGVRKRPSTSRPSLKEAPMFASSMSMGMDLDPMDEEEDDEDEVRAFPHSTVSFLLLAKWPLCGHSPPEDALECSQQGHVLRAKHRSRDYMCLPFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG31</accession>
    <name>A0AAD2CG31_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS3522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF-assemblin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000313">
        <property type="protein sequence ID" value="CAJ1933924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008374">
        <property type="entry name" value="SF_assemblin/giardin_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40412">
        <property type="entry name" value="SF-ASSEMBLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40412:SF1">
        <property type="entry name" value="SF-ASSEMBLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06705">
        <property type="entry name" value="SF-assemblin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01799">
        <property type="entry name" value="SFASSEMBLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="40"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1933924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="268" mass="31887" checksum="93AD15B7C2C73A69" modified="2024-05-29" version="1">MTSGTPISSPNRSAIVPSSKVQNVDTLVVSSSDASTFEEIMKERNRVRKEREEYSVAELKVQISRLEDALAAETKRRVDATTRLDDMARGQIFEMEERLRQQMKEDNQRLENRLQQVESRLEELEYRWKKDSEEQLEAIDQKSQDFEKAMKSLQADQDTERKARLRREGNLLQQVEHHVAEFEVRWKLEKEERENRVRFLEDHLNQQMVKRREEENVFQDKVREELALLQREMDEETTERKAQDAEIVEALNRYTMQLQQSLNILSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGU3</accession>
    <name>A0AAD2CGU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS3759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGU3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="203"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="243"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="366"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1934419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="482" mass="52208" checksum="D2047BE297827116" modified="2024-05-29" version="1">MAKSSKRSTKRPIESSTTTEPSPKKTRIPEKDDEIKRAENQSSSIQTNDEATNLVSAQSQIVKVAPSIYDNTEEQCDTDDSNEISELPPQIPQQKQVDDSTTIMQTDGTIHHPPTITRVMQPPPGLEMEFPTQSTADTRYRYFWAALFLALPFISIIGPSAFGSTKQIPNTTDHLIPPNHGLPVFRSSKTLRSFLLEQEGFHLGMAPAFFGYYGYFGALAAWDDELSNSSFPLLKQNIKSVAGASAGAMAAILLASGIPPKVAADFCSTISLGDFADPPGLLTVFRGDKFEEIMHNFMAAQNPNSSLQLQDSIIPVSVSGYDLLTLEGKLLTRGSMARAARASACFPVLFQPVGWVDKHETFLFVDGGLADYAGLNGLGAFGEETNGKKKRVVNIVVGDFQFGNVLGPSSMPKGVDASEVVSISIQGLPQCGPWAMERGPQAVTAARLAMVDALDLPMFQGKEEGHYELHIDASSYVPVVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHH7</accession>
    <name>A0AAD2CHH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000264">
        <property type="protein sequence ID" value="CAJ1933345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHH7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="29578" checksum="12FDD24FADF155EB" modified="2024-05-29" version="1">MIHSRILQKEADSPEFDNQFNYRSLIGKIAYLEKGTRPELAYACHQCSRFSSAPRKAHGEAIKRIGRYLLGTADKGMFIEPDLRKSFEVYVDADFCGNWNERYGHDPDTARSRHGYVITYAGVPIIHKSQLQTEIALSSTESEYTGLSYALREAIPLMNLLKEMKRHGIPVLDHRPKVHCRVFEDNTGALEMARVHKWRPRTKHLCTKLHHFRSYVTRKEITIHPIDTEDQPADILTKPLAVELFIKHRKWLIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK78</accession>
    <name>A0AAD2CK78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1936762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47643" checksum="782C11C5D1605C44" modified="2024-05-29" version="1">MEANELESVEKIKEKGILYFHQGNYQKAREMLEKVLEIQTKELGEDDLSVALTTHHIGNVLMREGKYDEALETLTRALEIRHTKLGASHDDTVKTYELIGSVFMESGDHEKAEKYYRTVVVIKSKFHSLESPALMNLNQNLALSLQRQGKFSEAQKIQKEVLANLLQVYGEDHSDVVLVYIATAGLLYEQNRPKDAHQMLDKSIEVCYRLKGLGDFNTQVLVRALSTKAGMLEVQGDLEGFTGTLNKVLMVQKETLGEMHPSTADAYENLADAYLGQDMLDECINALTKTLEFRRKVLGNGHPRTQELVSVLKPLKRGKIARALNEQGLAMRVQGDMDKAIQLFQEALDIYKETFLHTHPDMMAVYENVSAVKIEQGLLDDGIAASAEALKIRRRTLGDDHTDTKGSMEAHRSLLRRLLESQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKJ9</accession>
    <name>A0AAD2CKJ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000480">
        <property type="protein sequence ID" value="CAJ1935499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="138" mass="15417" checksum="BB5A5D1802F90AC0" modified="2024-05-29" version="1">MGKSPAPQAVSAHTTKLGVVKSAGKKLVKKRLGIDLEQPKDRGPVHSYDVKLKRLANKQGAPQMGDKMEAQQIAARQDTRHIDHYNIVVPKLSEWRLEQLYSGDVAVQLLTRLDCIQTGNALFSWAERYPDSQNQPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKP6</accession>
    <name>A0AAD2CKP6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000657">
        <property type="protein sequence ID" value="CAJ1937496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="289"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="731" mass="81628" checksum="80C738AD54C38719" modified="2024-05-29" version="1">MVRNNAAVVIATRPFLVSFYILILFALNPSGNPAVFAIMSTNNRNTNNTTNTTNTTNSTPASASASGYSTSSRTSSSSSSSLPLKMATRVDQVVKRVSQKGDEWRSLPMDTKIKLLEQIIQNTIQYRNEWVACHQSNLLFAHIDNDDDDDDDDPSSSTNDKITRRTRLMNNHGYAMVDILVRGPATLGSYANGILDSLKHNIQKNNNDGRPPPPVSTRTVGGGPRISRHGVVIEDDVENENGFYPEKIVATVWPSPWSLTQSLEAFGMKAEMVCDVQDSAMLQQTHDSYVQEHNSKLLVSNNKNVGCSAILAAGNFDAPTDLLCELFIKGRVCVYKANPINEASIPILKKILKPLLDLGYVEFSPSTSIEAAQALVEHQGIQEIVFTGSKATLDRIVWGNSKEEQDQNKAKNTPINTTPVCSELGSVNPWIIVPGPQWNKRSVDDHARAMVFAKMSNNGHICVSPQVIIYPKDWKFRQLFREKVEHWMSKHPGTVAFYPGSHETHQSLQQHPNAKLVPYGNPKKKSRGHDEEKQQSEPIFPGEQRPLFIGDMSLENERDQNLLRQEAWCPVLMELAIDAEDVDTKPMEYLRKAVDTANTNLYGSLSINILIDNKTMRRNKKELDHIIVHEMPYGLVGINVWPCYVNSMSQVRWGAFVGTDESGSGTLANAHLYRNVEKTVLRAPFRHLPRKAIQVMDPKKAHLVFSRFTTFKLKPNIITQVGLFAALFLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLA6</accession>
    <name>A0AAD2CLA6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5793</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042440652" evidence="2">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1937744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="76" mass="7921" checksum="03E9ED5FDE25E4A3" modified="2024-05-29" version="1">MFKLSFLLVALIAIIASVTADKPKALRRLQTAAPVAVPIAVVAPVAVPVAATSSSKGSSSKSSKRQLVHYNTPYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM06</accession>
    <name>A0AAD2CM06_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000553">
        <property type="protein sequence ID" value="CAJ1936136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="909" mass="97878" checksum="CC39170945D5A116" modified="2024-05-29" version="1" fragment="single">KQQKQQEQQDPPSSAESKTAEDLSGLGTVLEDLVEEEEEEEEEEVASPDAIETGVPATDTSSTEAPTTAAAEVNDKNEGLSKMEIQRKLIIKELREVFGKLMMMGEHVVESISLRDPTKEELNKSKRKSLATVEDSHKKIVMKDLAIRVSGIYRNDHHVVEAMSPDGSKVAVQVQPDIAQAATLATMALTEALENVDDEGKEEEIGQTDMEETPTLSLQQQQQEQQSKDSLPPTLTTLKPLLMKDLPRANFSFTSAAKNMSHDNHGSDDDISVLSKVTMPSIYVGMSKRHASSVPLCLNPNTGAITTQFHIVFDPTFSTAATNVDDLPDFGSEAWSKLFGDSVYQYVLDDPEDPLRPPDPTNNPPPPLTPTKPQVDSSGATIPSIQRETVIENPPAVSPVQPPPSQRENVTPFPTTPTNQPKPSPPPQPTPPPVRTPQPTAPPCKPAPQPSATRTSCRSNKAQTPKLFGYDGHGPAGYTAPLKSQSPETNNFYTYFSAYFNHSNIELEHSHDCSFIPSSYKARATKDPDVFTYNQAVNGPNSKKWCEAARKEIEELEGKFTWIEACAYPSVQLRSVGCNYNIGIASDRAHTFGDKSGLMGFSYKYTDIPYMCFNAAKSWQLGWYTSKADSITPSSSSATYSIKRAGIVEYDTTANKVLIQIRQTSSTTFYNINYNHATGLSEGTQEGANRVLVVSKDEAVDSNASMAQANLSSGNSFAISNFNGKSGETLTISFTLLENNEANVDIVLTGFQETSPTASITPSPAPSKAPNKILSRAPSPSKAPSKTPTRAPSNAPINAPSSMLPSHVPSIQPSAKIVASDSIQPSSTASASEKTSSSRALLTPASGNTSLSPSSSPSLGSSKTPSILRRKAPSTVPSTVPSDRPSTKIFTSVSIQPSSDPSASVMPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMJ6</accession>
    <name>A0AAD2CMJ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000061">
        <property type="protein sequence ID" value="CAJ1928864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMJ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="134" mass="15179" checksum="CD1CEECE32EA623C" modified="2024-05-29" version="1">MNLSDDFVSADYLSRRTECQAWYLAHKFAFDHNEGKGLDTFAKLYDVQSIKAKKAFDDDLKTSRARVSAVELESVPPATKYFELFKTTFESLKERAVRLVGQNTPVTAHPLERHLLPCRLPSILTCSLLQPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN10</accession>
    <name>A0AAD2CN10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutaredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS6063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000702">
        <property type="protein sequence ID" value="CAJ1938290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN10"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="155"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="263"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1938290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="37554" checksum="3545D4519BF5E280" modified="2024-05-29" version="1">MSKSSSASSLVEVSSSPLNIGTKSKAVLLFGASWHEACPQLEALLSALAGTAPDVFFAKIDAEENSDLSEQFQVTMVPTIILLNGGPTTDHIIVRMEGGFDPSHVTIGVQRLLSANEGLGSAEDSSSGPAVRPLPEDPEKELAARLDTLIKRDSVMLFMKGDPSAPKCGFSREAVELLQKHEVPFGSFDILSDDSVRQGLKKHSNWPTYPQIYVNGNLVGGLDVLKETAEEGSLKEQWGVTGPATVITPLQDRLASLVKRSDVMIFMKGLPSAPKCGFSRQMIGLLDESGVAYDAFNILEDSEVRQGLKEFSNWPTYPQLYVKGELVGGLDICKELAEDGDLVDTLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNY0</accession>
    <name>A0AAD2CNY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNY0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="214" mass="24854" checksum="E6839055C7271C15" modified="2024-05-29" version="1">MQLSLTTKFRPDLRKKPRRSSLSSSSRSLHSISAEDSKDVYEPKRRVSFCEIDVVELPMILGDHPACRNGLPVQPDWDASDRYSISVDSFEETRSPHRRSGGPIRISSFDRLNLIRNVPLRDDASPQIIGKDEAIPNTDKIITPPPITAVSEENTKSKVGKQNDELRRLEHRLDVANTRYDMLLSRMDDLELIRLKERIERRRRQRQRRRLSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPS9</accession>
    <name>A0AAD2CPS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS6839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 7"/>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPS9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000045">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000774">
        <property type="entry name" value="PPIase_FKBP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01346">
        <property type="entry name" value="FKBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042149488" description="peptidylprolyl isomerase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="60"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1940036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="150" mass="16123" checksum="C02858131E50FA09" modified="2024-05-29" version="1">MISLRSLIFLLLLAFAAAGTNKEGLAFLAKKETEEGVVKLPSGLMYKELVKGTGKTPTANSPCSCHYAGTLIDGTEFDSSYKRGQPTTFAPNQVIKGWTEAMQLMKEGGKWELYIPSELAYGDRGAGGRIPGGSVLIFILEMLEVKGDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPY6</accession>
    <name>A0AAD2CPY6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPY6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="452" mass="51166" checksum="E1363898BD368B45" modified="2024-05-29" version="1">MSRKDSSLRGSNHSTTRRSFDLLSPRNNRIGSKNKLSRKWRSEHIRRKSREEDFDDDSVSSSSCSFGCDDYYCQLSSKNVNLTATTTTTKPSSMITLPPSPPEGTAMFSNESFKMIYLSWDVITNMAQGKQQIGEKLFELLSDEEVPIARWFVGDKTAHRTSFVDMIDMLVSMLSPTDLDLVSDELKSLGKRHAQYNEELLQVFLPSLFQHLTDAFCKALKHCVHGHLFGPQPQQQEVDNNEKEEEEASSPPSNSRKMLARNSSQHDLFNDDSTDELEGKRPSNWKMVEHAWQDLFWYIRCQMEEGAMGEYQHQQQQFQEDSTSNKEYSVVLKSEDDAAEESSSKCPKPWSFSSRSTRRTSMSSFNSATSNISNDSAATPSSGSDASGSQKNKKKKTKAIRGLPKKLRLLRLNSMSTDLGFSSNHPSSSKTKPKDRGMKMKRRASMSSIPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRL9</accession>
    <name>A0AAD2CRL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRL9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042196298" description="YCII-related domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="42151" checksum="1ABA67BB81ADE4C9" modified="2024-05-29" version="1">MMQQTLLLSIILCVVGTEAFSVPSMTKTSLKQYNPQHHQQSSTLFMSSFSADGSEYASTDKDYVDDDIVEKEKFGPSFEDDVSSDVVEEKPVPMSKNAGNRFVAVVWDAEVDSEGRDSMELHEDRDACVEDHVLFCRKRNLYNETFNTNSMVDILRSLPLLSADLQRIVGHAMILESPDICHVKEMLAEEPFLKALNGGDWSKINLFRWRHIRDYTLRRDDGRLGYPCMMFGIDHDPETDNDSKQIREETKDAFMEYLIKSERIIMAGPLHMPTEIKDDPSSIATGDFILFNAKSREDAIQFVEEMPTSAEGLYKDLRVHFYNTLDITGKFISEDPMRDAPNYQMKEAMKEWGYPVEDNETRWLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRM2</accession>
    <name>A0AAD2CRM2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8371</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001213">
        <property type="protein sequence ID" value="CAJ1944152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRM2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="452" mass="49931" checksum="1DBA899F298BE4F0" modified="2024-05-29" version="1">MFSFIFMNNNIINTIINTITMPLALTLIVMLVAAMPVIAQQLISRVAVAPAVHSVIATQTTTIVAGVRAIFGSISIAAVGRTVSDAIGGITNIIKSFIGNATVLNSQIFALPTSETYLQLIVRAPRDLVLMATRAIIVRATRAIVVRATRSLVLFAARELVLRVSTCTDLVILGSSDLVPFGPQDLIIKVCAEALAHCITPVFAFVGQEVLNLPMNQTFSSEGNMMPWSPSILPIYSFGTAMTSTLSSLTRIMTGFFKLTLKTCVPVFADLIFLLLWTLASFICVMMNLANLTLQRSIETTKPVVRVFTDLISALSSWVCMWISALSIVSCTMTSLVKLAVQGMLEQYPGKVKYYWVVVLPNFCLKVGCDYLGQGPQRTNPPSSGKTIIGSYKRKMAKKRYDQKFKEMRERTERSFRLEAQIPGTRINLFQTEWEWAVIRRSNDETTLLSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSJ0</accession>
    <name>A0AAD2CSJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001247">
        <property type="protein sequence ID" value="CAJ1944765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="121" mass="13645" checksum="FE25C05CE79D1BA2" modified="2024-05-29" version="1">MSNQPNLLHISTSTPPPSQPSATPSAHHRSALPPNSQYYQFTDAEQEKFGELLEVSVQGRPSTPSMTKRDREAWAATKLPSPVFLAVNSPHGKDSLDRWFSTEHKFEHTWIFLLKSRYPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT43</accession>
    <name>A0AAD2CT43_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT43"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="444" mass="50711" checksum="0A651CE89E2FA66A" modified="2024-05-29" version="1">MRISKVGGRASPISLRVRKALRYVSITTLLFALTVLNSVQMMPLYYDQEAVRLQDVMRQKFENESHIDASSTRQEQSNSQHFVSTSKPSVVTLLRLDWTNQVPQSPLARRIQQHQMDCSLPLGNFKFRNRFGLGSDLHVWSQAMCNAMHFGVRIRTVWDWLWMDQQSCQSIIIEENKKTKRTLGSPLQCYFPRAELQCPSDSEIVLEHPIFDSALFNISGGRRQGTVNWDCSSILSSESGDGNEMQRRFQFQEAGMEFLFGQISQHVVEEANRQHFLVFGSGNTSQTTTPNDLITVHIRWGDKKREMKLLQIQQYLNAIDQLVQGRPRPVVNVFLATEDPEAVQQFQQQAPTDWKIYIDQFYTELLPHRNGNEYNGVPKAATALEGRMGTIALGSLLVALEANEFVITTESNWSRLLNELRKSIVDPTCHGCTKVMDLKPIQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTI4</accession>
    <name>A0AAD2CTI4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS9809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTI4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="152"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1945664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="348" mass="39143" checksum="1022534DCFEDE0DA" modified="2024-05-29" version="1">MAAMVKNPAEAAAVMPPISTSVEHSQSALPLTTNMTASSLTSGGNSCLDEQIERLKRCEYLREGEVKALCLRAREILVDESNVQRVDAPVTICGDIHGQFYDLVELFKVGGECPDKNYLFLGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVNVWRYCTEIFDYLSLSAIIEDKIFTVHGGLSPSINTLDQIRVIDRKQEVPHDGAMCDLMWSDPEEIDGWGLSPRGAGYLFGGDIVAMFNERNDLDLIARAHQLVMEGHRSMFNDALVTVWSAPNYCYRCGNVAAILELDENLERSFKIFDAAPQEARGVPIKNPPPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVZ7</accession>
    <name>A0AAD2CVZ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000735">
        <property type="protein sequence ID" value="CAJ1938576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVZ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="20393" checksum="B88FECD55829CC10" modified="2024-05-29" version="1">MNNASRGEHAPKAERNNQHLKALFWVHFHRMPFKAIPKMLTVALMTRVAKISHYYPAKGGLSEYYSLHMIMHQRMVDASKEFVAEIGAYVHGYGHDTKNNMAARTIKGVYMGPTDDILEGHRIYDLNTKCEARYAKIKVLPMTDQVIKIIEADARLEGVTELRTYSRRNGELMDNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWU9</accession>
    <name>A0AAD2CWU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF937 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021302">
        <property type="entry name" value="DUF2780_VcgC/VcgE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11075">
        <property type="entry name" value="DUF2780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="15654" checksum="E444D07D352E4BF7" modified="2024-05-29" version="1">MDQLMKLAGDAGLSEEQGKTATGGIMSMVKQNLDSGSYQKIVQQVPEVEGLVKDSDKEATGGGGGLMGQAMGMMGGSLGGAGQAGSIASLLTLMQSKGIGAEQMNAFMPQLAAFIKSKCGVDIGSQLGVSADGAAAPAPAAGGFDASKLGGMMGGMFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZT0</accession>
    <name>A0AAD2CZT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="127"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="310" mass="35992" checksum="F8EE08848E676ABF" modified="2024-05-29" version="1">MVAAKSWPWLSDLDQAMLPDKAIDPVNEYDTRESVPELLNEHASNIELVKEALKEDSLYEPFKHDDLWILRFLMSHKHKVKKATKAAKHALQFRNKHKLDEKDLRSIAPHSVPLGEEDTPFAGCDSLKRAWITRYPGDCIAFTIPDKQRGVAGFLRFADFKHDKATMKALSDEDLAAVFIYLSEWTFQWLDYVTRKTGRLTKSARFVDFTGFSMFQVSRDATKRDGKIMGDMEDVYPQLLHSLFMYNQPHWIHAIWATMRHIMPSRIVEKVDMVEPKENEQEFKRLLKFVAKEHLPVSLGGDNTVNPTEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZU5</accession>
    <name>A0AAD2CZU5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001230">
        <property type="protein sequence ID" value="CAJ1944683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="10388" checksum="8EFAE2265A1CF2BF" modified="2024-05-29" version="1" fragment="single">MVEACDRTGLSIDEMVVEIDLMANEDGVIPALQTPPIFKIAPIRITSKALEYLSPSDLGAAVDAFRSDIRYHDIEGLSKLFSPNDCRYFVAQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZV1</accession>
    <name>A0AAD2CZV1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001236">
        <property type="protein sequence ID" value="CAJ1944719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZV1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="211" mass="24466" checksum="D4DBEC38D18FCB8B" modified="2024-05-29" version="1">MERSFIYCPQGKWTMLQKRVYPLPKISDLLTDISGFTYASAIDLNMGCWNVRITPETSKLCTIILPWGKYIYQKLPMGAMSSAYIFQEAMNRLMEGLSHILTYLDDILCVTKGDFEDHLQRLELCLQRLHKAGLKVNLPKSEFATQQFKCLGYLVLRQGIRPLASKVEAIQQLKPPKTLKQLCSFLGMLNYYRDMWEKRSHMLAPFTELIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEF4</accession>
    <name>A0AAD2FEF4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS2886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEF4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1932537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="377" mass="40735" checksum="A3719C3BCE605A84" modified="2024-05-29" version="1">MPERRPHSILGVSKDASEAEIKAAYHKAAKKYHPDKQTSTQDKEKANQLFSQVNEAYESLMSQFHSSYGDEGREGEQDLAGEPPSRNRPKEGCKKVRKRSSTGRSNLSNSQRSSESAGENQKPSSFSRQPGPESSPRGHRRASSASNSPASNHSKRSIRMSRSNMVSPVPKSPSAKKSVRDSIRSKSPHATSSGTPRQRPRPVQRNSSTPSRHSSGPALGASAGAASAPHRRSRSSLVGGAPPPKPPLDSPVVTRKKHSPMNSPASPHGHRRVGSMRVNHNRPSSFRTNGDASLSPLRTKKSPVHARHGSFGSLNFHANIAPPPPSMPALSPTATKSLKKAKAPPPPQSTLQRLSVKLTSRNELKAEKKARAEKLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF50</accession>
    <name>A0AAD2FF50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1899153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1899153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="272" mass="32524" checksum="D4960B1E81FBD2C2" modified="2024-05-29" version="1">MNTIREVEKINQEELERGLAGTPASWHSQYRNSPWVYVGNLEHQLTEGDVLCVMSQFGEIEDINLARDEDTGKSRGFAFVKYEDARSCILAVDNLVGIKLCDRSLRVDHMEKYRLPKKLLEQEEAKEAMNFGAGHAYKDTELANQYSVHQGQDLFSPTDQKEEDEKKRRKEEKKRQKELDKLERRRKREERRIKKEEERRKHRASRYRHDDSVDEKDKDNSRRSRDKEERRKHRKRKHERKDSSSKDESSSSSSSGEDRKRRRKSHTRRHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFE0</accession>
    <name>A0AAD2FFE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000380">
        <property type="protein sequence ID" value="CAJ1934771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFE0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35996" checksum="FBF3FC9C6328975A" modified="2024-05-29" version="1">MDPKVNDKFAKRLNMRYGLIKACTIVRGKIHRYLGMTLDFSVKGKLKIRMDDYVKNMLEDFPIKFNKDSKQETPGGNDLLEAGKGKLLNAAYRQIFHATVARGLYVSKRAGLDIQPTITILASRVQEPTESDWKKCVRMMQYLFCTLLYHLTLSAESLRVMKWMIDASFAVHLDFKSHTDGTLSFGGGAAQVMSKKQKLNSRSSTEAELIAVDNVVTMILWTKLFMEWQGFLIEKNILYQDNKSAILLEENGHKSAGKRSRAIIIRYFFITDQVEKGNVKTTYCPTDNMIADYMTKPLQGEKFCKFRDLILGPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFV4</accession>
    <name>A0AAD2FFV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1921532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFV4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="248"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="561"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="738"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1921532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1257" mass="135440" checksum="AFA564DD7130C958" modified="2024-05-29" version="1">MTSGPLTPDMVPSDGKYHFAIDRGGTFTDVVATLPSGEIVVSKLLSEDPQHYLDAPTEGIRRVLEKNDVSSGIDYTRGRLVCTSNIGSIRMGTTVATNALLERRGSKMALITTKGFKDLLEIGNQARPDIFDLSCKTPSLLYHTVVEVDERVFLEKFCPAEMAATLERKVGITKEGVLIEKKPDLDVVKKQLEAIRDSGIASLAIVFLHGYTYEEHERMVGKIAKEMACFSEISMSHEVMSMVKMVPRGHTSCAAAYLTPKITEYLNGFTKGFDANLTNVPLQFMKSDGGLAPINDFGGHQAILSGPAGGVVGYAKTAFNSPNSPPVIGFDMGGTSTDVSRFDGSFDHVFETITAGVAIQAPQLDIHTVAAGGGSCLHLRRGMFVVGPDSAGAHPGPVCYRKNGMLAVTDANVVLGRIIPSQFPHIFGPEENEPLDVDGARKAFEELERLPEAGGRSPEELAFGFLQVANEAMCRPIRNLTQMKGFDITSHTLACFGGAGAQHACNIAKALGMSEVYVHRYSGVLSAYGLSLADAVHEEQIPTAEVYDGGMSDIGKERLAMLRERATKALTAQGYKEGNISTEEFINMRYDGTDTAIMIKQSENMTFSEAFEAIYRREFGFTLKDRDICVDDYRVRAVVAGKMLEPEPPTASCGIPTPSLGTSRAFFDNGWEEVPVYKVEDLNPGHEIPGPCIIVQPISTVVVEINCRAFVTAYGDLRIKIGHSEEHHLSADAVIKADPVKLSVFSHRFMGIAEQMGRTLQRTAISVNMKERLDFSCALFTKDGGLVANAPHIPVHLGAMQAAVRFQVEYWETNGGIQEGDVLLSNHPQKAGGSHLPDITVITPVFHEGEIIFFVASRGHHADIGGISPGSMPPHSKSLEEEGAMIIAFKLVEQGKFQEAGITEILMSPGKIPGNSGTRNLRDNISDLRAQVAANNSGILLLQDLVKEHGLEVVAAYMNYIQENAEGAVRLMLKQFATTHDKKVSATDFMDDGTPICLTIEIDPDTGSAVFDFTGTGPQVDGNHNAPPAVTYSAVIYALRSLVGDDIPLNQGCLAPIKFIIPKFSLLNPSEDAGVVGGNVLTSQRVVDVVLLAFSACAASQGCMNNLTFGDKEFGYYETIAGGSGAGPTWVGKSGIHTHCTNTRITDPEILERRYPVLLREFSIRQDSGGKGKHAGGNGVIRELEPLRPLVMSILSERRALQPYGMAGGDPGERGRNLVVKQNGTLVNLGGRCSGQLMLGERLRIETPGGGGYGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGB2</accession>
    <name>A0AAD2FGB2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000056">
        <property type="protein sequence ID" value="CAJ1928599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGB2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="141" mass="16207" checksum="AB86426A16EFFAFD" modified="2024-05-29" version="1">MQMASSAVLRTYLSQKPSQPFPDFYSYMNNKWPPNGDNIWRLYQQAVYSSLQPYSYSNVLRYTQEIWSVRFERGDTAAFDHTFAATRAYRDKKSMGKKCFADFNNGRIGEIGGIYAVPTTKLSNVSHGLTQAAPQLKMYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGG1</accession>
    <name>A0AAD2FGG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000080">
        <property type="protein sequence ID" value="CAJ1929340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="177"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="252"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1929340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="351" mass="40496" checksum="BDA5264317FF82DB" modified="2024-05-29" version="1">MNISSEFQDKRHLADEYNMPVVPYDASSCQQLDAADSLLLGLEKSMMSEKELWAPDTVGSSMYYNLDGCVNKAGDVFEPYSIARPTPRETSVSSHDLNMFMDNVMRPTLPEPRPFDQTCPSNEPGPHRQNDKKRFLEEHASINTAAPPSKRSRIFNVVEDDESSQEEEPLPKFRNYQEQQWQEQYQGLLQYKAKHGHCCVPNAYPPNPVLGRWVKRQRYQYKLRQTGQQSTLVTPRVQALESVGFVWDSHSALWEERLNELKAYRIAHGNCNVPSNYPKSKQLSTWVKCQRRQYRLFGQGKNSNLTEERIGALDDLGFVWDGRMVGNRCKRVVEKSQPRSSRLSRRFAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGL8</accession>
    <name>A0AAD2FGL8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000106">
        <property type="protein sequence ID" value="CAJ1930105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGL8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="227" mass="25074" checksum="0EAC70968198BFB8" modified="2024-05-29" version="1">MTDLFGFDAAPEDSPIPECFEVYEACKPPSILFSPRQLVNYDNESAPLKVSSFKDLILDSDKPARKIPHGELDLCPPPRVHFNDTLTVHKSTSQILTTTKKSTLDNAVAFFTDFVLKDDLLQQLSEASMGRDDATSALPPVHDGNKSDREPDQTIDEIATNKSILVCTLGILEATLDCTLVSLGPLDFDLIDRGLSTANIPNAMLIPKHCTDHGQNVLDSTYWNWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHF6</accession>
    <name>A0AAD2FHF6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS2648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000198">
        <property type="protein sequence ID" value="CAJ1932010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHF6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042152933" description="Rhodanese domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="397"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1932010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="445" mass="48639" checksum="9F036E565F16E637" modified="2024-05-29" version="1">MRVPNLLLALICITLLSADAFSRSHRRYKLSSSSVSANRSGEPVGLSNTEISRYSRHLVLSDVGMHGQVALKNSSVLVIGAGGLGSPCLLYLAAAGVGKIGIVDGDIVDESNLQRQIIHGTSTLGMSKCESAKKRIRDINPHVAVRIYEEEFTSTTALSILEGGFDEQTQYDVVVDGSDNFPTKYLINDACEIVNIPWVYSAILAFEGQMSVFNYCHGPTYRDMLPTPPPPGDVPSCAEGGVLGVLPGTMGCLQATEVLKLLLRRPRSQITSGRVLVFDALQMKFSELGITRDSKRKKTSTLIAYDGFCSGPPVQETIIGSSGRTMDEAERVTGEEKYSFRSIEPRKCLEMLSKGWAPWVLDVRLRTEHDIVALPFTDEVAPHRSVKIDQVPISGDILVYCKAGVRGKKACNRLIELGIDPLRLHNLDGGIIGWQREVDPTMPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK14</accession>
    <name>A0AAD2FK14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="152"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="329" mass="37316" checksum="9B5EEA743AD193A6" modified="2024-05-29" version="1">MTDLVDLLKEDFADATDAEITRFALGYGKGGGRLERRKRAAAARLEAYLDWRKKFELDKEKSETGDLSDSKTWEYAVNKAWDVVISHQEAIELTKKLEAEAKLKTDDQEEATDYDKQMEEVMKEPPESKEEETEGNDDNDDDELPPTATIKRSNIDQVLFRHQLEGKSIRDKGGHTILHVLPSRIDRKVASAIIYANAFAFYLDMNLDRNSDEKITIFLDVRGGEGFPNPSPKTMLKFISTVSRVLEFNFPERLEKLIIFPVPMLARGVFQPIKLLMHGKTVNKIELISGSANRHAALPKAALEKFIDSKVLDKTEAVRLGCFKLVDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKA5</accession>
    <name>A0AAD2FKA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS10189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051084">
        <property type="entry name" value="H+-coupled_symporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="33"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1946048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="474" mass="50754" checksum="7DF84C91FC006267" modified="2024-05-29" version="1">MSSSPSKQQDQVNLRSADGLMQGGELPQYDFKTKMAGIAGNVLEWYDFSVYGYFSDIIGKVFFAPDATGKAALVESFAVFGIAFLIRPIGGAIFGYMGDNVGRKSALENSILLMALPTFIMGCLPSYASIGWYSTALLIICRMLQGFSVGGQLMSSVVFALEASPESTWGFQAGAVFAATTLGAVIGSLFAYALRENLTEEQMESFGWRIPFFFGVVGIIPGLYLKHRSKEIPVPKPAPQISPDAVTTPSVGGHPQLERQGTFQETFAPNNRRALIASMLVPAFTSGTYYIVFVWMAVYMQTIVEVPHAFGINSAVGVIGIGLCFAGGWMVDRLGAKSRVPLMLGSSLAFGLVAPYFISTMGQGDPLTCFILQGTMAVLMGIFGGAMHPWLISNFPPHIRLTSTTLAYNMAVSLVGGFSPFVATLLQEEYGNAAPGYIVSVLAVLAWLGLIIGSTAKTSWKDDRANAPKLSSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKD7</accession>
    <name>A0AAD2FKD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS9351</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1945207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="493" mass="55369" checksum="E669F83784322AC5" modified="2024-05-29" version="1">MKASQQLIRRCSLLDSARGSLQRQTTANSSLKRKYPLPAFPIKPHHVETRLLGATPSDFHETLCEAIRNAQERVYLASLYIGPGALVKYEQEHELLDALRSTKEDVDVKIILDQNRALREVPCDNGEMTSSAQAVADAIKLQDNHKLHLFQVLPTSLDALLPNPLNEVAGVFHIKAYIVDDSLILSGANLSEEYFTDRQDRYLCFSDGGNGLVDFYAKLIDSLCDNSVAYQQGTTNTNVKKIMSPASNTRLLSEINDLFCSEDPRTAEQLLTEDSDTIAVCMPTFHAPSGFWDEAPEYWTDIEATLSLLREGGSDDTTSRIHLSSAYLNPMPDLLKSVQHYPEANFVTAGPLSHGFRPKKQQSGNKGKAWIPTVFDHLIYEASKETHANMWHWERKDWTFHSKGIWIEEGEELLSHVVGSSNFGGRSFERDMESNLLMVFPPSKSSEVSISLQDEWGELMKHSKQVNTKEVLDSAPELPIHVKSVLPFIKSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKJ5</accession>
    <name>A0AAD2FKJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001402">
        <property type="protein sequence ID" value="CAJ1945403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042139436" evidence="1">
        <location>
            <begin position="24"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="245" mass="27477" checksum="712C1EB9C69DB245" modified="2024-05-29" version="1">MFDRTRNSLLTLCLLLILRNASAQRFLREGFSSKMESDFKAETKLEGASGLTREMTLMKDTDWELQPATFENIRDARFRRHLESFLQTPVTLKLSTRKGKYGLRAVGHLASGKRLRAFWRQSTNSKKLTPDGFLSATYDDAIRCRLSVMEFEIQLPPHDKKSKALPSVIFSVPVEPGSMNSKAIIPRGAVNVRVLPKGRISDDLGPQDVELGKGHVHLPMRAGLVDAAWAKGRSVFRKGRINGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLG5</accession>
    <name>A0AAD2FLG5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000968">
        <property type="protein sequence ID" value="CAJ1940847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="154" mass="17994" checksum="5D4EF66ED0364FFB" modified="2024-05-29" version="1">MWRLTLLFIQEDDEGDFQDDQVALVPLSIRSLIKVIQGYVYYRKHVHNDPVNPDNCMDIDYGSVLDYRASGELLTFGNRTIPQPIIQKPSRCTPADEFDRSIRQDLSSFPTFSNDKQWENYNCNLPAICRTYGLQNVLNHKYRPQTVDEKDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM51</accession>
    <name>A0AAD2FM51_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyruvate carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS8959</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM51"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041930797" description="pyruvate carboxylase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin carboxylation" evidence="15">
        <location>
            <begin position="64"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="186"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="16">
        <location>
            <begin position="613"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="13">
        <location>
            <begin position="1152"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1944581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1228" mass="133294" checksum="6B0875CBC7BAA590" modified="2024-05-29" version="1">MMRLSCTALFVAIAITSLTVSEAFTNPSVGSGIHTAATRLQATVEKEPPIADTAPLGDDSTKPLFTNVMACNRAEIAVRIMRAATELNAGTVGIYVHEDRYSQHRWGADRSFLLEKEDDATPISAYLDIPQIIKIAKEANVDAIHPGYGFLSESPEFAQACADADITFVGPTVENLNRFSDKTSAREAAIAAGVPVVPGSDGALTTKEEVTAFVEDIGLPIIIKAAMGGGGKGMRVVRSMDDLVSSWESASSEALAAFGDGAVFIERFVDRPRHIEVQIIGDGTGNVVHLWERDCSVQRRHQKVIEMAPAWTLPMELRRQLHDYATALTSAAKYKNAGTVEFLVDSENRPYFIEVNPRIQVEHTVTEEVTGIDLVQSQLKIAAGATLEEVGLIQENISARGVAIQCRVTTENPERDFAPDTGTLSVYRHSAGCGVRMDGIGYSGLTITPYFDSMMVKYTARGSTFIETVNRMNRVLQECRIRGVKTNIPFLMNCLQHPDFRAGKLTTAFIDENPELKQTSTSYWQFANDEQADPRKVFRDEQLLRYLANLAVNGHPTELGADSSKLATQFKSSVAKPVIPAPKPGAPKKNMRQIYLEKGPEGMAKAVRANEGLLVTDTTWRDAHQSLLATRMRTQEFARCAEATNEALANAFSLEMWGGATFDVAMRFLHECPWKRLETLREKVPDVPFQMLLRGANAVGYTNYADNVVYKFCKQAQSSGVDVFRVFDSLNYLENLKLGVDAVGTAGGFVEGTMSYTGDVADPTKGKYNLEYYMNLARELVDMGSHAIAIKDMAGLLTPQATTMLVSALRKEFPDVPIHVHTHDTAGSGVASMLAAAHAGADVVDGAIDAMSGMTSQPSLGAIVSNMKGTGIDTGLDPAQLGPLNTYWENVRSLYAPFESGQLSGSSDVYQHEIPGGQYTNLLFQSKQLGLTEKWPEIKKKYAQANIVLGDIPKVTPSSKVVGDLAQFMVAQNLEPADVLEQAETLAFPDSVVNFLRGDIGIPPGGFPEPLRSKVLKGRGLDPIEGRPGASLGSYDFDKERAALVSKYGEKYINEKDLLSYALYPNVFTEWKEYESIYGDVETLPTRVFLNPMNIGQEIELDMGPGKALSVKLASISDVNEDGTRVVLFEVNGEQTYISVTDSSVQTEGTVREKAGAPGTVGSPMPGVIVGVKVKPGDVIQEGDTVATLSAMKMETSIPATSSGVVTRVTVNVGDKVEGDDLLVEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM55</accession>
    <name>A0AAD2FM55_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001225">
        <property type="protein sequence ID" value="CAJ1944643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM55"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="122" mass="13443" checksum="540B3119E6235DAA" modified="2024-05-29" version="1">MAKKEKGNKVELESKYAAAQEEHSNMKTMMGAARGMIQRLLPQEGNKEELDKIEASIAKAKLSHNELQNDSGFLDAMTPESRKAYTDHLEDGINANMAVVKKSRNKPLFSDAASDSDSDDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMY5</accession>
    <name>A0AAD2FMY5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMY5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="222" mass="24411" checksum="F3786A1CD5E8B85E" modified="2024-05-29" version="1">MSTIRIRTAINQNNAAVSMIGSARYNEAICMLKASMRQFQKELRSHAANDNVHSEPCATAIHHLILQSATTSLLDRGDGSNDEAGFLYDQAVFIPQRVSLERHIATHVVSSIQIFNLALALQLKANATKADSRLRDSCLRNAMSIYRLVMMLNGSNGLLSMIVLNNVGLIHRACKNHDRASECFSRLLAIWMVSPVCAKYLEGMIHNALGWYDTSALPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNK1</accession>
    <name>A0AAD2FNK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS11160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001728">
        <property type="protein sequence ID" value="CAJ1947471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8 11" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="13">
        <location>
            <begin position="387"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="270"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1947471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="520" mass="59402" checksum="9495A6A9D820FC53" modified="2024-05-29" version="1">MAESSVRTEDIEGMQVELGEDLSMNEEKKVESEASSDENSASVSSTESDNSDTYDMDTSEAKKDPELLLIKATRLKEEGNTYFKAQDYEKALRSYRRGTSTLKPLNKANTGDPQVKSLLVSLQSNLSMMYFKLNKYKESAVVASSVLKIENNNVKAFYRRAVANRKLGEYKKARDDLREALKYDSKNSAVRKELASIKHSIAKENGKARQSMQKAFSNGGLLYDDKEEEKRLKKEAEIESKRKAEELKAKRRKDWEDECVRRMARGESACSFDEYEQESKKQEEEKEEEERKRMEAEKERRRKLRELTKADDSDSDEELTDKELQALRGYKTLRDGSVTSYFTREQTKEEKMLAAQRNAPKKLDSGSQQSDIVSSGSKWNTAQTWEERDCGIWCRDRLTQRLKQTKVESAALCGFITEATDMTGDASVALVSGKKRYIFDFHCNVDYEIRDSGSEEVVASGSMKLPDICSTHHEELEVIIDGWKNGPKDNINAAAECRDSLVSEIRESVTLWVKDFNEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP31</accession>
    <name>A0AAD2FP31_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001740">
        <property type="protein sequence ID" value="CAJ1948094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="309" mass="34157" checksum="533405CA909897FD" modified="2024-05-29" version="1">MGSDDDQSDEMALNLTKAATDQGQGGLEEKIRSNSTTQLTVDLVKDDPSDDPMELFETVWHALIPPKSRHKQPPPSKIAEDGALKGQPLVASPKKLNPSNDPMEFVEIVWHALIAAFPPTIDQSLDRFSIGWSTKQGRNQNKIFNYLHTTTILFYDVCAAHQKWPTTMGSNEAKSQEMALKSTRTAPEHAQEGLEATTRSNSTTLLTVDLVKDNPNARISSMLYSLFVLFLSLEKIQQTDFLGLPFQIPTNRMGAPICPLTDDLRELHSILSLEKVPTKFLCNPGDILASCLYFPTNSGSANLSPDMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPU4</accession>
    <name>A0AAD2FPU4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1948959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="20271" checksum="4A5485DDFD08A235" modified="2024-05-29" version="1">MPNQIGAWIKTEKGVRRLMKEEVARGLGINKGCKTELSHKSLQRTTSLFHWEYLSFSLQHLFSHPTSASGKTTQGPKTGNHLSGATTITLDNDVFNGHPPDLSLGSPWHTLRLANLRWAADHYPEPDNIYWDGIQRLAVHRNNYNSEGLDPKQLQLLWWEFPSEHWEELRNGHARIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ07</accession>
    <name>A0AAD2FQ07_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KA1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KA1" evidence="2">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="454" mass="50374" checksum="E90691774558AED5" modified="2024-05-29" version="1">MSFFSSNNNSRSESESSLPPAPESLSANQLPQSLLISNSSSSIAMPPRPRTPWAVKDHSLKHIPKYYPPMDPNCTAFVPGTTASVVAFRIAECLRQHSVAVEYDNESITANAMTVDRCHFEIQLWKGKITPTVDYSHGVVVEIQRRSGNTISFHQVCTAILQAARGESSGADHRKPHQTNAMEYTHMPSLTARPPTLSRKPAASTSDVVSAKVTLEKIQEQLRKDRLECQQLAMERLIQLTTPTVCGYSHALETSKILLSESWLYPYIIAEQDETEPMEADEPKSTSFALLKPTLKRSLSPRLTNDNFCQNEKQHETHLRAFALRVLFNALSNVVDAQNKEDAQFLSNLLQSPDCPLLESKLLETLAEDLQGANRPPSVVEASIGLATIHEAALAVGCLRIMAENAPAVKQFWNSEHMLERLQVARSCGRSTHAFLQAQTDLVHYSLTEDARSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ16</accession>
    <name>A0AAD2FQ16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="84"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="162"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="248"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="321"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="470" mass="53959" checksum="21EAB06A8D4A1C72" modified="2024-05-29" version="1">MTLRKQQETWEVRLKELKAYKVANGHCNVPLHYEENKQLGRWVDKQRTYYRQMKEGKKSSMTAERIEKLEGLNFRWKIRDSDHVPWEERMKQLKAYRDLHGDCNVPYHHPENKALGKWVSRQREFFKFRQEGLRSSLTDERVNELAEVGFTWKVRDQTDYVPWETRIRELKEYKKKHGDVVVPKDYEANKKLGRWVDHQLSFYSMQLGGLPTPLTAERTKELEALGFSEEMLQDTEHSPSSGHSSVLDANWKKRLDELKQYRDEHGDCSVPKRYKANTALGYWVNTQRKHYKLLKEGKKSTMTNARIQELEKLGFAWNQNEAIWNKRIQELKDYSKEHGHCNVPRNYSQNIELAKWIDSQRKQYSMKRDGKKASITDARVAELEGMGLTWKPRKGAPLVPVVGAVEAAAPPPKAASVPAVAAPPAVKPAPDPVPVPPAATKPAPTVAPPAKPEAEAPAPSAKDGPASVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQG1</accession>
    <name>A0AAD2FQG1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1949560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="426" mass="48590" checksum="08CA7548F3493EEA" modified="2024-05-29" version="1">MNELDYRRSMEARNSVTLNSNMDSFDLINLLRNLPKDIVGEDNEKCEILTLHRVDLDYNTVYEIIDQLFRWSQVEFDDSSGHHMYALLNAILKHENIKHLSIIGDELDPDSVEAMKEGLCSCYLHELVLFIELTREAATSIILEGINNAPSILKLDLSQCEISPDSIEVICQALETNESLVSLNLENCRLQDDEIAEILLSLQDNQSLQHLSLAMNYAEDEAMNAASRLLQSPTSRLKSLNLAQQNPGTLDLLSLSAGLRENKKLQRLDLYESFVDKQHMAAFAEVLTVNTTLRELNFENCGLKDSILSLLLVQLKRFTGLQKLYIKKNELSKQLDPSTIRGNFMLQVLDVEDRLMHPQVYIDLALNRGGRQYLDQNMLPMGLWPTLFERVNRYFQETSDDQAPSRCHHGFSSADALFYLIKGSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT93</accession>
    <name>A0AAD2FT93_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="434" mass="48509" checksum="C2B0B8CBDB1C3045" modified="2024-05-29" version="1">MAIDERERDLNSQDGGGSQDNKNSFNYVAPDDDEYQNTYRVQPFAEGISEYDEYQQAWRFLGFMVDCNAKESDDDNQHDGGGSNSYDGGTGEGCERYLLWAAYVDLEYEGDGIGEYQYYNIDNNAWDKTSCNYADSGNSRCAKMDCHLDSTHFSLLGFFKHQSYDDWMEQLFKHEGVCVWGMQQYSFMNSARNTWPQGCSLSSATTSSGKPIYYDLKPISKGGMTPGLYTDTKCTVEYQSTGSDDPNTIKNILGNFLIDGGDGGGGSNDGGDYDFSGLSFTQAMNLWEYGFEHFKVCQPCVAYNLNNVGGGYYNDDANQGGDNFDCYDQAGYTNVNQCMKFMAKTSMNTATFRDLSLAQSQGTLVDSPLAGFMDSRARSAHYMMESAGTVMNYVFLAVSVVVLFYGVTNFWRVRRKVKLAPKTSQRMDEPLVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTQ7</accession>
    <name>A0AAD2FTQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS13201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1951714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40224" checksum="FAE3B656E2C1BE2B" modified="2024-05-29" version="1">MSSFVLDKFGSNCRLKFGEECVSVDFEGKRITTSSGRTIQYDLLLAADGVNSRIREFLVQKEQELFQEQHYLEDIHWKALQLPKQPDIEAGSFKPLQHPSFSRGRVLPRAPEGHILLLFWKEEHGIENPAGVETTDDLKQMITEAMHGKNTRGTNPLRKLLGFNRGDSDRKRDWNEVFDEAALEDFISKRAGRTHHLKINQYHFQDSVALIGDSAHAMNSLLGQGCAAGLQSTYTLVECLGGCDDQTLSIEESLLKYSQLATREAYAITDLNLIHYATRGRMAMLKALPLAVWNKLRGRSLRKQLSDITVPYSQIAAENKGLLKLSRRNFEKERRPFVNPGIAAAIPTKNELELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU30</accession>
    <name>A0AAD2FU30_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU30"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="146" mass="16710" checksum="3155D29A3BCA146B" modified="2024-05-29" version="1">MIDYLLRNRLPKSAELIKMILEKTLLARLGMWGVEILRMDLTGRIESAEWDGDVTSRQNVLESIIQRSEFYGMIQVTSVLELALWKKQKVNTAHLSETKRAVIDREGRRTTCGANVVIPAVLAKIILIGYQLVMLQFQCWIIMHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV26</accession>
    <name>A0AAD2FV26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="392" mass="43579" checksum="56C9DA56E5BF2600" modified="2024-05-29" version="1">MGISTPSKFLTRLNQRATIIKHPTANLMIAIGTSTQGQDQANIANAFVCDPKQFKMLDPPMLAIEQSQSPYLVNANAEIGEPCFMYLQTSKILVMQMISCRHFCVSIEAEHLFGSIAKDVVKTHHLIKESGQVYSSSWMTGSFEGGKCGCLTKLMLLLLLQASRFTRKSADDILEKLVQDLEVCSLVCTAMKYWRGTKEIGPDGPPIQRQGGDGCSLRTKVCQCLSILHDAAKKRQEESQALQVKPKSRQVTSVEGALPQIKDSATLPSNDDGDGLVVPVGKPLLQRKGSATLWSEDSSYSSLLKEKEGRVDLGRNDWRRPFGISPAYTLEYEIPLPFFGIVLAPLRNTEKQMKILLGSVLINKGNHQNKKTLVQSIVQQTLQHMEDLRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVI4</accession>
    <name>A0AAD2FVI4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS14724</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15567">
        <property type="entry name" value="PHD4_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047365">
        <property type="entry name" value="Tudor_AtPTM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23011">
        <property type="entry name" value="PHD-1st_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21743">
        <property type="entry name" value="PTM_DIR17_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="812"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="1664"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="16">
        <location>
            <begin position="1741"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="16">
        <location>
            <begin position="2167"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="16">
        <location>
            <begin position="2265"/>
            <end position="2333"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="11">
        <location>
            <begin position="1741"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="11">
        <location>
            <begin position="2167"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="11">
        <location>
            <begin position="2265"/>
            <end position="2333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="350"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1226"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1711"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1834"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2479"/>
            <end position="2827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="246"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="2217"/>
            <end position="2244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="2315"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1841"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1888"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1935"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="2479"/>
            <end position="2488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2493"/>
            <end position="2506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2544"/>
            <end position="2556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2586"/>
            <end position="2596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2644"/>
            <end position="2655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="2656"/>
            <end position="2666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2682"/>
            <end position="2694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1954129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2827" mass="319327" checksum="6646AED20BEE7DA7" modified="2024-05-29" version="1">MDVDSDSQEAGKASNKALEARDDSESDEDNDKKPAAKNLDDDDDDDEGSDNDDDGNDQEDDDQEDEEQDDQDDDDGSKSDNSESGDDESSDDSDDSDDSDDEGISSYEKLRMERIKRNQQRLQQLGLAGKSGTSAFASLKPAKPVKRKPRKKVERIMLPQRSSRSRSAKRGVSYAIKYDFRGKEIVKVNKAPGARRAAKKPRVVRWIHDEFRRIGRQRKHTLKSATRNLKAAGKELSYWSRRMQVFTEKKQRIVNFEKKMEQDKKEREEFGGYTRSELLREIDRRTPQLEGLLLKYDIQEANVAKTEEERQALLERMVQREAFDRKMQMIDALDRFPKALRDATTSLNLMLYNRSPKDPAPPRRSKRNSTGDDRGQEDEEGQTKDDDKGEDGWTNLVVDKPTLPTAESATKNRKKDVRNVGGWVSPIFGQELNRAWLEREHALQNFDLDTYVPQVGDTILYYPGVHKAFLKKHPDMLWKMTRNPLRVPLWQRAFKERTKGITGGSDTWWTNEWLDSPDLEAYPLVCRVERTHAEFPPDPYAHYRTLDKDGNVVWRHPKSLKPKKRKTGMRLAVLLKPLTPLLPPTFDEDNGLMDDKRCSLPPKFYVSTAPMKKPFVVPFVWAFALNHSIRENEAVELPDIDSNKAKVKAFKGLESSQYGSFRLDDKVQLMHRILDDLESTGVGATSLQDRIEQQMTYDGSGNSFSATDAGLIVSYLKADLNERGAIGKAANTEVNGNLLDLIRSCLPLSQNIEVQPNAFQRKTIRVSWWDLRQKKTSKGRHTTLPGIQSGCLHSLEDSLRTKIAFSVEESLNEIEFCEIFSDPVTDEEAPGYSCAVPIGMYFNRILNRLKVTKGPTCYYTSVESVLSDLQCVADNCLLYNSLNSDIAKLCVDIVMGIKRQVSDVFAKHVKEQSNRIKAEQERRRFVLENCGPSVVGDDTSKRRGKGHTVPDWLNSPYEGKLYRKWMQRLDQDGSWTINDGASQEAKIQNWAPQSGDVVHYSRSLHAQFVKGHMESLAKEQCVVPRFSSSTSETANDEDAENDIDESADDLLPKLESHWLLGNIVSVRSTFPRKEETGESFDIASPVLAIGLRLPYPWAKGKVFTVCWRPCSFTENEHSWKCSSCNIGMSSFLRPAWLAKDETQRDYRVLDCSGESKLHSETGPTGIPQPNRTSIATCFDIIKKRCLAETDPDIVDPKSCFSNAERRVATKPPTSRALPSFETLLSEFEEEPTSSQKKASSRKNSSTKDKKEANARKVLSKICFLPPWCDPVAAEKEDTAETFKTKLPLPFLSLEQICLRVKNGYYRQPAAILNDLTESYVTAVLYLLSNATTRKRNQVSLRKITKYLHTTTKNSKPTKMIDAKDAKQKTRSHESVAKTMAPVVRESLFDNEEFQSLQGEEKEWIRRIEKIRKLYTMAILCVTDTGLLQHIFGLPIQSDDADGVSQDKSNSEEETKLQEEGIRHIRYLLSAVTRDPSDLTQPFKGQMKIRIRCNGKIEASGVENDGSEGARVLGSNELERNDKLCRVLIGQPGRRAACVRCQVAGSSMLSCRVAKSHANVDFAFSDFFKNGQGVDGLIAAATPNGTSGMKGGSQLSTQAIGGPRIVGSFESELTDPTDNFKKARTTFELAKMLQKEATMLSQAPSRLGDDFIRSYFPVDESDGHYIYCIVCGRSGDLVCCEGCPTVVHADCIGLSNVPDGDWFCNKCNSSGNTEDEIKSGGDGNTDSKNAGSRDMVAVDPFPRSPMPAYFQFLNERRTEIQNQNEGASKSEISKILSNLWKSSSDEVRNKYMDEEAAQRKAYQLAIAEYRKSKAGKQVDEAQSYESAIKFLESVKEKRKEAQQAQAGQQTSAAQPTVAQKSNENDAGETKSSDHGPLARKPAADSSSSRNDDLNAEKPAPDAEREDIEHPVEAKPDFDDGDLKAEKLVTENEQENFEQHAEAKPDINGDPIKTQDEKNDEKKDETAAISDPEKLKKASSESSAKLEAVAPTKPQESDDFDYLGEVLSRARQASQKDCARKCPKGVGLLVKKKNAYCHICHKRSDAAYGFACLHDTHNYCLRHAMERFDFSSELYQLDHCPICCLRCECSACKRKANNLAREFKQHCRNTNKTGKEAKFKGILDRCAVVSGARLTSFVAWDDEISALDNTPKQDINITAPVATEPIDRPKKASSAYFFFCKEFRRKIFEDDPSTEFREVGKILGERWRALDEEGRKKYEDLSNADKERYEKEMDEYHEKLEKAAASAASTASGFDEEAIPHDDIPVPQKPYPAYFQFANSKRVEVKKANPGVANSDVSRIIADMWRDLADEARQYYVDEEAQQRKKYNEEMEEYQKKVEERYKMIEAQRPAKPVAPRRDPAPRQDSPSLVPEAIVNEQMQNLGALLKQLSSLRPKTAYTPRKKNIPPPVIPVGTKFKKHFDDHGEFEGKVARIPDDESDLYGVEYDDEDEEELTIDELLPLVSEGVRDDYKRAQRDYKARLNRKRGRPRKIVVNEDSDGENDSEDEGYLDQSKIDLSPKRKRGRPSNIAADLIDEEPPRRKRGRPRKVDPRVENEESRQKRKRSANPDPLDSQPVDGTPRKRGRGRPRKEEQSLEPKLKLPLGQPRKRQRGEDDLRVSSTTVTSPRGKRGRPRKRPAEEPEAIVQLEREESPEDPNKRRSKRSTKFRKVMTVPGESVRDLFAGSNVTMTLGSSRSSLRAEKPSGRRSQTPKRFVEETNSESDPSPVAETKRGRRNRTPKRLVADTKAEVQEPDPSPVAETKRGRRSRTPKRFAQSPEMSTKKVVQQQQKRAKSLPPSTTTGTRRTRHSDATSTKESGGREGTRSRGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW33</accession>
    <name>A0AAD2FW33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="487" mass="55469" checksum="05B53B289BC35D88" modified="2024-05-29" version="1">MIGSSAPGSSTVPIVLAPSRFNHRFERTTVDSEPIQLEVENLDQAQASKTVICGICKNKQSRYMCPRSQITYCSVACFQQLPSSSTEAFYENRAQSILQLETKEHEEGTLRMLNRQYQQQRADEEAGVEKEEEDDVDLKELKELLSMVMTMNEEHDGNEDDSKRETNAKHSLEKLLSSMSPSLRAAFERDLQNGNLQNLALQEWHPWWRREFGNGNSDGMEESGEEIIAVSNVQPTKTLDERLLKIPNFNQLSKKPNPQLLFHVLDIVYSYCWTLRLFHGLSNIIAPKSVISNSQDSPASEAVTTFLSHSEVLYQQGRHQYSSLEEVLIKCTAASTKAKDECNTNWNVLVEDCSLIFSSRRSVARSLVEAIDMIQAAVQDCKKQRKEKGPEYQIEQQIQTLRKVRKKLVFLVAWTKQAAELEGQDDISISIQIEEWGRYWQHSNGDEELHELQIPTETILSSPSDKKASSEQHAATPWMTIAETRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ96</accession>
    <name>A0AAD2FZ96_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042154952" evidence="1">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="160" mass="17739" checksum="933EE00385F7C8CB" modified="2024-05-29" version="1">MFFSKQVSTTLAFLILASTTVDGRRRRPLITKGEYEFGQNATEAEEADCAGSPDFSCKFSVHREEGVFVCRSWINKNGIERKKVGCFPSDRSILGTDECGCCGKECPTICNTCTCKTERGRAGAYIVYEGRDEPVCRSTFIATKLVHRDESIACLADCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZR0</accession>
    <name>A0AAD2FZR0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001979">
        <property type="protein sequence ID" value="CAJ1958417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="134" mass="14875" checksum="D101EDBFB53A73B4" modified="2024-05-29" version="1">MKVVPHPSDHLWFVCFVGVEDAAALGVTKSLASARCGPTFRHDQKQLPLWAFLQTFRETPLMIPVEHTLNLSLQHYWIMHSEIEYFSMLVAGVSKAALNALPCLNPMNPTLMAKTILRQATANNMTAPSTSAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZZ2</accession>
    <name>A0AAD2FZZ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="650" mass="71275" checksum="6DADA76103EA2E35" modified="2024-05-29" version="1">MTEEEIAKKKKKKKKSIVEDGEGDENNGETIKKKKKKKLKKAASESALTADGPVKKKKKKKKKVAGDFGGDSSDDDDDFLPDSPLKDEPKKTLKRSKSLSGDSNHSADLGSIRENGAIIPRDRSSSPSGRPKMRPSGAGRGMQRAQSLNFGGRGGGMNRQGSSRNSMNGRGRGMGNRQTSRGGGLSISEHGPGRGGRGMGIRQPSRGGGLSMSEHGPGRGGRGMGMRQPSRGGGLSTSEHGRGRGGRGMGSRQSSMRQSNRFNGGLDGGSNHGGNKRVMMARQPSARVEMDGQIEEMSVGSSRPGRGRPSLADTKRSYSQASMSLSNHSLDLGDFGDEPKWKKVLRYLHIMKPTPDETPIQRKQRYLIWFALFLDFIAAMVSIFSYDGVTTCCEVPIFDTASTVLDWDVFIRTTTYIYTALLFIEILPVLKKGLPINLINPLLGFGITFGMFFDDRIFEAVAMWLIEASAIGCEVVVFLLKRKEFNEGQKRVDDATTEIESRKPKSRKSKLARGSSKTSFDDDLGLEEGANSDLRNLDNFRLERERRRLRVAQSTEEISLRYHFIGTIINCGLVVLSMSLIAGVGKNGGLCIIDLAQPPLFANDQQFRCAACFTPENENNKDFWDEDGNVCQICDTSEGGTNHVCYYSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G033</accession>
    <name>A0AAD2G033_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G033"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042037379" evidence="2">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="186" mass="21167" checksum="1BD43F9E631CF0E9" modified="2024-05-29" version="1">MRSQLQHLLLFCITGIATASFKIPFLSKKKQYTPLIFFTVPKDVIPECDEMEKVVSEVERELGVKVERLDIVRDPAAEATLAALTNRGPPYLYNKESCQVISKEADDSGAIKQTVIDKDRVRAWAKGRFLMPKSAKMGNMKVLSQKDNSLDQKDLVEDMSLTEMQKRGKEAIKKRTEEKSKEKRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0D7</accession>
    <name>A0AAD2G0D7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like superfamily protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0D7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59580" checksum="BC795E10DCD51275" modified="2024-05-29" version="1">MEHHRKCRFNFAWSHGYHPNYRFGRAELSDARHILIEPPNYPGSFRIRNQIWDAALFDVFVNLFDHFASENIIWEEFDFFFMSTYDKKSWKFIRPLLQRASSLGIYKKLRVEMQLLFGPENPPDTTKEFLLEGIDRNENLQAIELISVHTKSSDPLVRGEHPFQMSKGDCIALNRLSEATDSLKELSLNGIGMLQTMGASDGEGEQERIWYHPLCEGLAKNSSLETIKLDFVGCRMTDMSLAQLVMSISNIPTLKSLTLNFPCQAGPLTSAALQDLLLKCHSLTDLVLNGPISVSSSNHEEVETEKESVNGNAGPLQLDASQILHGIQESRSLKSLKLQRIMNADWSLSRIFEAIWSCQTLCQIEVDDNVEIMQDLEALISMERFDRHMRLILPVDQYLQDYESENAVEVLQGFLFKHPEMRLKPPSVLSKRARNKRTTSNNPSGFFSQRFMALMEESMFLSKSLKHICDFNWHGRYLMHTPAVPLGLWPRVMERATTNPSVLYELLKSPALVSWGGGATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G106</accession>
    <name>A0AAD2G106_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001924">
        <property type="protein sequence ID" value="CAJ1956682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G106"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="132" mass="15384" checksum="02E2F3E37047C3D8" modified="2024-05-29" version="1">MNKSADAEYDFLDFWEANQKFFAMKQGTTENLMHFKERFLRQAEVLQDLYGVAWFRDFAVKTKAYAAIASTDTAAQNKFKDDIFEAVLATGFLCNCDRTRKAPLMLDLQMNYCREVDYYPKTVSKAQDKQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1S1</accession>
    <name>A0AAD2G1S1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1S1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="32490" checksum="13918FDAC9907C3B" modified="2024-05-29" version="1">MVDRGSTAWQLIPTWSKDSRDSNAMRFLTASFVPGKWDVICHSGKESQQHIGNRRFSLCIQNHLKSYAGSNSRPARSAIITNVVASIRDVSEGGFVRLDLASGRWYEVGDKMARDKVGQALRDAMNSDTQERSMSPPQEQRKRKRPSCGGSNSPNTKQNSTPDTPKQMEKTHIALDINPRHNAWPNSNEMPMRLNPPFTTGESRVQTDSLRIVREPTDSGFRDGKVNDANNKCFVSVIGKSTEATATATVKAKGQAKADQSPGDASGNSGRSSTSDSHQLSLIEWFEKDVQNAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4H7</accession>
    <name>A0AAD2G4H7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4H7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="609" mass="68263" checksum="F27A786BFB368D4A" modified="2024-05-29" version="1">MHFKRYDVLDVFTIVFPSKNAIGEQTIQLETDNFNVTKTVFLFDRYTELTADQVAESCKWYTRWPDATTSPWFRENLRLSYDYLCNHMTPQLWSKVLKDLLPYRDTQGMGGPLVVFFIMKRLQVNSQLVVKTIQGQLRTLHIDQYEGESVDDLVSHIKVMLTGLKSLEKRIDGRVVSSNVPHDIGKTLISLFQTSSDPKFNEVFHNKEINAYEQALTQGDAAYGSPDMILDLATSIYQNRMASKEGGTGQFHKVNETAFSAQKSVGPCFNCGGKHSVTACTEPINKERVSQNKRKFFDEKKAQKNPGKKGRSRLGAGVQFEHLPSETNNRPHALLSGAPTPAPAAPAPAPPAAAAPAAPAPPVNQVPSGDASALTAATSATNLPQIRQQVSAIATGMNQLIDQVNRATLLLRMIVVFLSTVIPSYPSVTMWWPLLQGGMDEFRPHLKCSNALNSSSILSSSRGATSSSKYLPLLVPTPPSNALELLGCAFPWRCCKSKSPKRNSPHYHLILKALRRRVKPQRVQFYRKTARTKEKKRKRQHKQAEKQATSVPHHWNSPSDEEILEDYTRNKHRFLHLSFIQIDAKYGVDLDQFVRSVDPLKQYHQIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4Z1</accession>
    <name>A0AAD2G4Z1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartoacylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS20036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4Z1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050178">
        <property type="entry name" value="AspA/AstE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055438">
        <property type="entry name" value="AstE_AspA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA_hybrid_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002601">
        <property type="entry name" value="PRK02259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15162">
        <property type="entry name" value="ASPARTOACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15162:SF7">
        <property type="entry name" value="SUCCINYLGLUTAMATE DESUCCINYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24827">
        <property type="entry name" value="AstE_AspA_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA_hybrid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Succinylglutamate desuccinylase/Aspartoacylase catalytic" evidence="7">
        <location>
            <begin position="51"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="AstE/AspA barrel-sandwich hybrid" evidence="6">
        <location>
            <begin position="299"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1963171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44264" checksum="1431663B89B666C6" modified="2024-05-29" version="1">MSPAASDCHRNQRRLSPNVRTTFLLNLMVVATITTIPYCCNGLSLYKTSPIHRVAVVGGTHGNEYTGVWCIRTIEAQQKELKAQYPSLDIQTILGNEEAHLENKRFIDTDLNREFKCDTLCGVDGDDVVVMEEEEEEEPASREARRAKELDALLGSKCDSDNGSEIDVAIDLHSTTANMGLTLIINEGDELMTQGAAYVVGKCPGAHILMHSIPEREDRPTLSSAAKHGFTIEVGPIPQGLLRHDTVLKTESAMHALLEFFQRKNDGVDVQAELKETYPDGHVPCYRSAPARRDGEISGKITWPCDPVNPNFPALMIHESVQDKDFSLIKVGDPLFVAHDRSVVPYDGSHGDEVYLIFVNEAGYYYASSGTGIGVAITSYYDLQTGMLKEEKENACYTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G663</accession>
    <name>A0AAD2G663_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002155">
        <property type="protein sequence ID" value="CAJ1963647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G663"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29892" checksum="F85F25C8233A1755" modified="2024-05-29" version="1" fragment="single">CPTDSSSGILASNPDITIKIRSGQGNGAGPYIWVAISAILIDAMEAEGFGYKSRTALTNKEFFASCFCFVDDTDVMESNDNVETTGEDLLPLVQSALDLWSGGISATGGAINPAKSFWWLIDFKWRPSSGTWVFRRKAEMPGKLTLQDPTGPWATLRRLQPDEAERTLGVMMAPLETGTAQHLALREKAKNWAAKFRPQHLLRYDVLPLLKATALKTLEYVMPLSTLGRSDWVSIMSPILQASLHKAGVCRSFPRVMVFAPLNYQEHAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6Y3</accession>
    <name>A0AAD2G6Y3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6Y3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="301"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="374"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="460" mass="52109" checksum="6C19556101BDE472" modified="2024-05-29" version="1">MNHPFPTSLQEDREQSSSSSGGSAEAYQAHSFHPISQAPPIWPNTERPLPPSPIQTTNSFDGGYSNSPLPLRNPFEPRGEEVLPHPGEHFTFEGYHDQYKTDPPDDAGREDPKQFPFASPPHPPSFAAGFYANTAASPFHQMHPQPYDDYHADPHNPYVSHHHMVYRFEPQYYLPSTWHAMYKPTEMDQKPAAVSYSPSRPPISPMKASNLLPINVPPIASRDPDAYAASNTTSTRAAASNSPPSPVAAARRPQPRRSRKARGARRQTATPQIRGNHVHQSPTATELEEATTNRAQKAVRSWYQRFNELVDYTNKFGDTAVPQQYEDNHALGIWVNKQRMEMKAYGEATRSSMTRRRMDLLENIGFEWAKPKGQAAWDEKFRELLEYKSVHGDCHVPTKHKANRPLGRWVSTQRNMKKNCDLGKTPKSLNYEVIRNRIQMLEEIGFAWSMIESPTSNDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G823</accession>
    <name>A0AAD2G823_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002210">
        <property type="protein sequence ID" value="CAJ1965629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G823"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="62" mass="6302" checksum="E63446C91034FC93" modified="2024-05-29" version="1" fragment="single">VYNNTVVTYGAATEDYLKDGGTPISNFVPAGDGIFPGIGVPAVAISGASAALQWRCLDSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G883</accession>
    <name>A0AAD2G883_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G883"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042196676" evidence="1">
        <location>
            <begin position="23"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="462" mass="51847" checksum="F5C7AD8CA94CDE99" modified="2024-05-29" version="1">MDFKPRFLAILLIFLCPANVESFHLTCSLRNDISSSKTDWLSLNSVPPRRAYEGLPSTPGWKGGQLDRLTDWAVNDEANRPVICEYEPEGTYLWSKWKGTVLQLIYPAVIFNTFVGILVAYSAREFADSTWPLFAIPPQDDYLIQQLHGFNLIWSYQVTLTTFILTFFTSEAYKHWKDVYFATRRIQGRINDICMLVTIGATTPNEEDKNELVKKCTRLIKLSHTFFWASTPTSSNGVVDGGWENDEDIHSDIEIGPILLSNEGLQGLVDVGELTTEEVDSLLSSGLPPSQYTYVLLEWVGLLIMDGLERNVLQNGNSGLEENILRQMSALRAEYFSIGDYAAGRMSLAYVQLVQVLVDSLVFLAPVCLYSDVGSLSVPLVGLLTLFFKGLLELSKSFLDPFGNEGFKSQNIRVDVLVSELNFGAQSRWTSAADSYATLKKKEQQRLRGEELPISSYVDSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G912</accession>
    <name>A0AAD2G912_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G912"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="329" mass="37218" checksum="55B0C628A24544D4" modified="2024-05-29" version="1">MVLTMSTSLAILQIAETCRFEHGAGLKVMKGVERNKSLNKLIISESNLSMVAMSSILRAVSDGEVPKLVTLDVKLKPRSDCIQLLTRLMCSDTCHLEDLKIDEDDYDISSMFRTDGIPTGTVNRMLEKLEICFGRFDDSYLASLLPMMPNLLDLDLKSCNLSDISPIVNHLCHPSTAIRTIELCDADEDIGLDQVEYFASHLRDMQSLTDVYIGLSFRGDDENDGLERFQNILRIFSSCWNLETFEFYGLSDTLEKLVKESNLNLTFAINGGWRRELCYNQHYRESSAPPPKLLPLIIARALRNTTVRSLRADVVLSLLRERIGDIIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G995</accession>
    <name>A0AAD2G995_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS22116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002296">
        <property type="protein sequence ID" value="CAJ1966532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G995"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1966532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="865" mass="96703" checksum="94EAC8B0F4407D6A" modified="2024-05-29" version="1">MSDNTVDKNRDFQEKTEEFNWSAFYDDEGRIYYYNEKSGESSWDAPARFNPPPNDAAEQSSVKDVDSTAEDNAADASKDPDKNNWVLYHDDEGREYFFNTLTEETTWEKPVEFEKRSEKSPDEASTVTAKSPEQEYSDRISENIEDDDSLQRIPAKEHMVDDMQVEEKQTEPEVIVDQLEVAEQALKLPDAILEPGVMTHLTEIVSRDDGNPERAIQALSKSYNGTTAVCGLLSRWLADLKSLSAVADVVDTEKRRERQSKAFRKSTDDIREMAQAVIFRISREKFTNGGGDNILNLHKAEVAFLEKMMDSKRWRGLLIDLSASNKDSAMLRYCLRAISKRGHHREIANRIDQSDHFAVFDAMLASEVAAVGKIAVSLCQEQDSTIHLDELVSGLRRTCTSTAYTYIFTLEVLDHLVTVARRKAVGLHGKEYRVFLRAIRKWERLGDDLKSSMIDPASTNATPLFRKRRLDVAMTISELHQRQRRRTLPDGNNITGRRPVDEVEAKRENAVHSFLRQYSLSTRVDDSFLDSILESGSTELSANSSGALLVKRPISVKALLGYLYKPGGQRVGSVVTKKKCAMIIAHSAIAAENEITSASNEQSEETIQVTDKVALTRNLVDGSNLCQELENMVSFIVTQNATKKAQQSSGERLVVLATGSSLVAHGVAMWARNMVKGNDFVSSGTYATVSPSILSLVRVLYTIHKSLRDDSLEVAFSFLSHSNTDSDVSYQKLNEIKEQSLRLLLVLSVAGESPTALLRMTQLLEESGSSALDSSLIRYFVSGLLSVIQGPFSIPFMRTLAAFLKVPSCVDALKTSYFEATEQAKLSVVMNVFRQELDSKTAVLNPEDIELFLSLLSNYATTRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAZ1</accession>
    <name>A0AAD2GAZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS22586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAZ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042274788" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1967045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="219" mass="24926" checksum="7AC9C06C20993544" modified="2024-05-29" version="1">MVSSISKMALLLILGAILSPCDAFSYVVTLQPENEDCFVILIPRGKLSIIGGSFQVEDNDVSPKDFTATITELPKGNIVYEPKKEALAGHFLLKSDLRSTHYSLCFRNNARDDDDNSFDVGFNIRVGDLPRGRGEEEIGPETKRAYELVDRAVKIHEDWSVMLDHLDYAHNREAVYEDLASSILYRLAKWTYIEAFLVIGMATGQVMYWKKFFETKRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBN6</accession>
    <name>A0AAD2GBN6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="158" mass="17302" checksum="5419BE3F9F630F5C" modified="2024-05-29" version="1">METTIKNKASSSFNTNTSISSASNATQQADCLKGNNTFLARLSRPNSINTTTSSSSTTTSINTMNQHASHPLDANSDNASQESRIDEAIDIIDSEETSNNKRPKRQSLQRKGSSISERSAKELLHDNCNRLTVLVQRSSIEMTRNGFLSSDDESDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCN7</accession>
    <name>A0AAD2GCN7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002408">
        <property type="protein sequence ID" value="CAJ1968817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCN7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="160" mass="18023" checksum="2E60759814C3C6F2" modified="2024-05-29" version="1" fragment="single">MVITNAQNTAFFTQDAQMAIPLGIFAPHLNQQGITTIDSLKEFNDGMLDDIHKHITRHGPPNDVFSALSLSRLKTAASAVRFYLVTGRALTAACMRWTNTVIMYQEEREELKIAQEREDPKVPCVSKALPIMKWLAAFRSVIHESYGVRGFPLGYVLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDH5</accession>
    <name>A0AAD2GDH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002491">
        <property type="protein sequence ID" value="CAJ1970281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="371" mass="42161" checksum="43DD1A80773CAC98" modified="2024-05-29" version="1">MITIYAVTDGLKHDGHLSPFPSATGIAGGIDGSLVIPKNPNSTIVDDVSKIWHDPGKGSICVHLKQSARCPYPALLGRLSESALAILDWQVQKTESSSDGGTIHSGGYSNKWLDAGDYLVEILILYCEGFGVGAWETFDNKTAWLEAGFKSRCIEDSKRNRITWEEGNKISIPSSTEGKGSYHLGRWVITPGIPLRPLFTRHQPVECTDPMKGYRPLEPLQKCCEPLTNRDKPTNRTSLWNHEQGDDVFGLPEYQFQCRMNITEEDLIAKLRKRQQDASTEKICAVGDSHRRLMLERSLPQLRLTGMFEYIKQSWIRTYKIAPEIVDRKCDQVFMQIGRWTPSWYTRNTPFSFAKYHYRLKNTYPKRAQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDK0</accession>
    <name>A0AAD2GDK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Agmatine deiminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDK0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047632">
        <property type="term" value="F:agmatine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017754">
        <property type="entry name" value="Agmatine_deiminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03380">
        <property type="entry name" value="agmatine_aguA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="AGMATINE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377:SF0">
        <property type="entry name" value="AGMATINE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39818" checksum="69ABCE4B108AB05D" modified="2024-05-29" version="1">MPGEWSHHDACLILYPHNPKTFRLVRVQEEVINVTRAISKDGEEPVFLLCYNDEQASELKEQIGEEGIRIHTCPSDDTWARDTCPTLVWNSDTKQIEGLDWDFNAYGGPVEGCYWPCDKDQQIAKKVCQDILNVKCHAISIVLEGGSIHTDGEGTLLATEECLLNPNRNPQLPKVTIETTLKGCLGVSKVIWLPHGLDADEDTNGHVDNFCCFVKPGHVLLAWTDDNVNDAENYKRCRVAETVLSSTTDAKYRKLVVHKLGLPPPLYYTKEEAISLSNESAEAVGRVEGEKMAASYVNFYIANKAIILPQFGVPSDSIACDTIQALFPNRKVVGVGSREILLGGGNIHCITQQVPAPCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GEK0</accession>
    <name>A0AAD2GEK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS24491</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002524">
        <property type="protein sequence ID" value="CAJ1970475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GEK0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="15">
        <location>
            <begin position="210"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="53"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1970475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="906" mass="100070" checksum="B193FE4EBE86AECA" modified="2024-05-29" version="1">MVDLNSLKDEISSIGNKIKELKNMAVKELTVTDEIGKNVQDLLAKKQLYAEHNNGIGIDGKPFAKNMTKAEKKKQAQAQKQQQPNQQQQNQEQSQAPKAENASKKAAKKAEKAAKKAAYKAGGGAPAAGSGGGGGAPPPQQQQQGKKQQPPPQLAQKKAVPPPTMKRGGGFQVKPLQMVINPNAPIEDRPVVALAMAVLTNTDIDLELTSDHRIAQATLGGEAEAGDETPQIVGDLSMARYLVARSDKNEFASVSNSQQALQNAWIDYASSLKPLSKEQALKGIGMTLGHALFTKTYLVGESLTFADVALFGAMAWPSQSSDLAAVTAALQANDYTAALRWTTMMASHPAIRKATQLAMGVNGTTEVGGDLLEPLVSGMNLLEGAVPGNVVTRFPPEPSGYLHIGHAKAVLLNDYYARRYKGRLIVRFDDTNPSKEKEEYQQSIVEDLKLLGVDPDVVTYTSDYFKAIFGYALSMIENGTAYMDDTPQEQMKLERADRVESKHRNMPPEEAKEKFLMMNSGKEEGAAWCLRAKIDMNSDNGTLRDPVLFRQNLEPHHRSGTTYKAYPTYDLACPIVDSLEGVTHALRTTEYNDRDEQYQWIQTTLGLRRVRIHSFSRVNFMYTVLSKRKLAWFVEQGLVEGWGDARFPTVRGVVRRGVNLDALKTFIYSQGASRRVVNMDWSKFWAENKKEIDKQAKRFMAIDANTNVPLKVTNGPAIDSNSYLSTANHPKDPSLGSRALRIGQDVILETVDVEGIQEGEEIVLLRWGVVKITKVTQANGNVGSLEGEFIPDGDYKTAKRKLSWMIQTGSNPIVELTEFDHLVTKDKLEEEDNFADYVNPTTLATTQVMGDAGLKTLQEHEIIQLERRGFFRVDRPYRDGKPLILYMIPDGKTKSMSGMTGKLAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JG93</accession>
    <name>A0AAD2JG93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JG93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="391"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="479" mass="54010" checksum="290466A965D981F6" modified="2024-05-29" version="1">MASIPESGLSPRNNKKCINCGSFGQSVARPVAASSEMKSAEGIIAAELKGLSIQERVTALDDLHCVGQGQEEDPEVIRTALEKFEEEVRNANHPAYNLAVRKQNPYVQDSEYRLRFLRGALFDVKKAVRQMLSLLQYQAEYFGVDALDRRIALSDLKEEEVRVMLNGMFHYPTQTDRNGRYVTYCFSNVFLAGIPAETMIRSCLYANSYFTSFPDLQKKGLVGVYMDIGEPDQSIQLGPRFFSWVFNLMKFMLCLPLKFSSSHYCINVGNSKNVAIHKSVIETFIKVLPSYARARTKLHYGSALEIRYSLQSHGIPMDTYPIDSNGNIRQDMIDSSCLKHYGIDASNYRGVKTPPNLDSNDAPTAVIPSIAASSQQNRSGHIVPLEPKLTDVLLGRGKPNQNHPGNIQLRAMIEECQEEYDAIGRLEKRQMIQNIKHACHSIGTRFLKQQGNKNTWVVANSSEADEKIRQHFRCARKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHB1</accession>
    <name>A0AAD2JHB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS12137</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041933162" description="GH16 domain-containing protein" evidence="12">
        <location>
            <begin position="26"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="13">
        <location>
            <begin position="87"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1949520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="645" mass="71732" checksum="58378A1870AEBF6E" modified="2024-05-29" version="1">MSFSMERLVVIALLIQFCTFNLVASDWIDPDTPEEAKTTQPLTVTPYFVRKTAPKEDSDSKKEKNETKAPTTAAPTFAPTIKPTPFPTYSSHKYELVFSEEFNTPDRTFEDGTDPRWTSLEKNDYTNDALHYYSTSNARTKDGSLVIKTEASDTDVVGFDDVKRKNTHVTKHFKSAMLQTWNKFCFTGGIIEAEVELPGKHNVGGLWPAFWLLGNLARHTYVGSSEHIWPWSSGVCTTKSFSAQHISACREVGHYGMLPHVGRGSPEMDIFEVQPGDIKANNGPFLRSSVGQPFMSASFQVAPGLSNFRPGPGYWPGPGQWYTGLVGGKNTSLNVGFYGNYNHFRGDPHPEKSDYWSDAISYNRQLDASHFNGSHTYRLEWDVPTAEKDGYLHWFLDGELVLAINGTGVATAGEGSEISSEPSYIILNTAVSKQWGFPIQCPAGCECKEFDCHSSNYSAQCGFSPGFCKMMLEGDPEYKINSIRVYQNPDFEEQKVGCSTPERPTRRYIEGHADLYKEDKDERPLKSIQQGRGNCRPGVTNNARDICGGAEHGTCTRGKVCECKKGWTGPHCLASAGYNTIEWDVPDSIADLGFIPPSMFPRALLIGLLLIIVAFFLAMQLRSRLGGWTPIPEVDTKPRSWRGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHB6</accession>
    <name>A0AAD2JHB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="332" mass="35793" checksum="D72832009CD3425A" modified="2024-05-29" version="1">MAAESVPDGNTILFGRGKACNYHPGNQRMRSIISNYKTQYRSASKGEKAKLVRKVYDELVGGGMKFMKQTEGGDGWEDVDESAAIQKVGHVLRHKLKPTSIEKKSLAQDASGNASHGERLKCTSNSSSIRNLAQEVAGLHKVADVPLSLRTWLPLTGSALHNDGGLGQSLTRMPTRIQCSVGSNPRNEDLSQHLSMLSSIGALQQQIGRTSLPQGPGLPSTDDLLQNKNHRRGLVQHRADGFNGHGVANRLQNQLAQMELERQRSTLSALMGPLTPSGLPPLLSSRNQLSISGQGNLLGLLADANSQFNPVPSDDPMFWIRLAAASLLNKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHC0</accession>
    <name>A0AAD2JHC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1731 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11092:SF0">
        <property type="entry name" value="EPIMERASE FAMILY PROTEIN SDR39U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11092">
        <property type="entry name" value="SUGAR NUCLEOTIDE EPIMERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="345"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1950908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="41789" checksum="70A500308E292231" modified="2024-05-29" version="1">MHSRPSTMTVIFAAVQLSTRVASRQSKATNLSHQLFRRGSSLRSLSTSSSSSSSSLNDDNKYFTIGLTGASGLIGTALRDEISNIGSINGKPVRCVALKRGSKADKKPLNDDSANTSLVWNPNGKTPEEVIDPSALQDMDAIVHLSGENISTGLSGPLAPLGIRPWTDAKKKEIIDSRVITTRALAQAIAKSEKKPSFLVAGGVGAYGPDFFEGAKAADESADISKSTGFLAEISRKWEGAAQEADDSGARVVKMRNGVVLSTKGGAMAKLYPIFLLGGGGIVGSGKQYFPFISARDMARAMIHVLQTPSLNGPVNMCAPSGCTNAEFTSAIGKVLRRPTILPFPSFAVSLLFGEMGEEILLGGTRAQPQKLLDSGFEFAHPTVEEAVQSAVDEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHD1</accession>
    <name>A0AAD2JHD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11834</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1948917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1948921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042440815" description="VWFD domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="62094" checksum="9FC211C5B6EBDE80" modified="2024-05-29" version="1">MKIYFSIALSAAIFTNVANAQSLFDYSAPATGSAKCALINVIMDESGSMGGDQTFLKNVALPKMATELHSSNHNYSDVFVCSSGFGYSRTNNAQAYRHLGCTTYNSAGVIANSTALAWYANGAIEDGWYAMKHGMQDVPSSINGTDLLSHCARVDKNLILVTDEDRDDAYSNVDATNIANLIDTNGYILNVIANYGINNNINDFGMNIGGGGSNSTIFRFDSSAPDNHMTYQDFRPYETYVTSFGGTHPHYTELIVDKPGAAWNINSLRSGGLRAQTFADIFVDIKVKEISNGTGGPSGGGGTVRVGGPEAGGDPHITTWNHKEHYEYHGQCDLVMVKDPTFADGLGLYVHIRTKIVRYWSYIQSVAIRIDDDVLEIEGSADAHDDQAHYWKNFEYQGDLDTFAGFPVTQKLPSVYKRTYTIDLSSKFPGQEITIQLYKEFVRVKLNGNEQVFGNSVGLLGDYKTGKTLARDGVTVLDDFTDLGDEWQVLPSEPTLFHEIAHPQFPELCLKPEDPRGERKRRLEESSISEEDAEKACVSLKDPLAIKDCVYDVLATQDVDMVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHD9</accession>
    <name>A0AAD2JHD9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS12216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHD9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042108812" description="coproporphyrinogen oxidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1949675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="387" mass="43629" checksum="EBC37579DDF20B0C" modified="2024-05-29" version="1">MRVISTCLTILSAASLAQAFSPVRPSSLGRGGSQLHSTAEKTEGKKAGEDAPPVSIGWDSHQAVEKIPDSLVREGDGPEGNYPMRSKFEKMCREAQISITKAIEDIDGDANFREDCWTRANGGGGMSRVLSGGKVFEKAGVNLSVVYGSMPQEALQAATERGIDRSKGMAPGERVPFFACGLSSVMHPKNPHCPTMHFNYRYFETDGGVWWFGGGTDITPSYVNEEDMKHFHGTYKEVCDKHDPEYYKEFKAWADRYFVIQHRNETRGLGGIFFDDQNDKDPEEHFAFSEECLNSVVKAYGPIIEKHKNDEFTEQEKEWQLMRRGRYVEFNLVYDRGTVFGLKTGGRIESILMSLPETARWEYNHIPEPGTPEYDFIDACKTPREWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI26</accession>
    <name>A0AAD2JI26_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">GTP cyclohydrolase II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS12968</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000001">
        <property type="entry name" value="Riboflavin biosynthesis protein RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="17">
        <location>
            <begin position="181"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1951226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="652" mass="71567" checksum="FE3826B8051DAE74" modified="2024-05-29" version="1">MKFQISTNSRPNRRRALSQCLIYFLGCSMLGMCTSEAYLSSPNAFLPRELKTRGGADAVRRKTTNTMKMEFHDGLNFNGDSQSEVTLDVVSSLNGNTNGSGKVNGLKVNGKNVNGKKVNGLAIDKKVNGNMVNGKKVNGFVNGVVSQEVRDNVNINAKSFDKKRVINGDDEDQQVPATFIADTKLPTVFGQYRLRAYRFENTSNEFTGNEPCVIYSEDNPPFGKDGKFLESVPIRIHDQCLTSEVFGSQRCDCKQQLRMAMEFIQHNGGAVIYMPQEGRGIGIANKVAAYALQDTGMDTVDGNLHLGLPEDARQYGCVPSMLEDMKIASIRLLTNNPRKVHRLNALGVKITQTEPMVVPETNPYNHKYLVAKHERMNHANLSPLINGKMLARKAMVHATDGQRTVENAVQVSLSTEEELMQENGKATEDGATAGEDGYCFGRQSVEDAIAAIQEGKMVVVVDDMDRENEGDFIMAAEACTPEDMATIVRYSSGVICVGMEGARMDELKLPAMVTNNEDPKGTAFSVSVDATKEHGITTGISATDRAKSVRMLANPNTFPTDFSRPGHIFPLRAKEGGVLARDGHTEAAVDLSILAGRGRAGLLCEIVSEENPVEMARLPELKRFCKKHGYVLTSIVDIAQFRRETERIADFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJB9</accession>
    <name>A0AAD2JJB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Photosystem II reaction center Psb28 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJB9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021503">
        <property type="entry name" value="DUF3110"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11360">
        <property type="entry name" value="DUF3110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041973165" description="Photosystem II reaction center Psb28 protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18674" checksum="CC505346938668D4" modified="2024-05-29" version="1">MKAISLIFTLFLTSVVQGFLLVVPQKKNAKHNPNRMRSSSSSPGAKTTGSSTTLLFQTPNAIQEQEDNYLQLAMQYERRPDVVYVIMYNPGTEQEGIHTMEFPRGSETDLLLAFESIEDCVGFSNSLRQDPNWQQEPVPTPTPLDQVEIACQGMGLPIKIVPDTSQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK92</accession>
    <name>A0AAD2JK92_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS17543</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK92"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042038996" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="842"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="891"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="931"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="958"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="796"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1010"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1013"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1959119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1068" mass="117157" checksum="1CDF4B72110B0492" modified="2024-05-29" version="1">MRSSSVSSVTLLWLGVFLGVISAAAVAATPDWNCDPCIKRTDYHIRAIVHGEASDDYWVQTSAAMHQAARDMRVDFRMDNLVDAYDPAQMAASIRSLIPTSDVAPNINERTPNALIVTIPSDEVREAVEELIQKTDIPVFGMNSGYQIAKDMNLQCHIAQDDFLAGQEAARQFLKLYYPAWNETGSPTTMIFNNNSTNITTSTTPHRALFINHEHGNSGVDDRYRGFRDTLQAAFGEEHVVVDQLILDPVQESSHEKAIAQALEGCPYTDGVLAPLQKLELLTSAYYKNECSFVAQKSGIFDVDSKVYDAIALGKVAFAVSQQQYLQGAATVTLAAIYATTGFQLYFPSGENRHGTYLSGPKVVKLQNLPSDSQQICESEGFPVCNNDGTSPNPQGRCPCRDRSNIRIGGSTPHPESTPSHWGVIWEAARHAANDGGIDLILDELERLDATESEFDKIGQKYVSLCQSGVDGVFGSAVPFDEVLDLCSSLEVPFVSVSSAVEESHQHAITMSHYNSAYAASQKMIEAGMKRGYCVQWHLSNDLDDRCFGLRDAIADSGLDITYEGVIYPPEGQTYHDNVLLYQKIVHDFIPEEGDWEGIGLLLVSDPFAEGSVLLQDQHPKLLIGAFDSGEKVLQYVDEGRILFAVDQQPYLQGYLAVRLLAWYAHTKQSLFTQLLESGPQFIYEAPSAELQACKAAKFDVCPEAVFYNKNQLDQVRPFGLAFACILIALSLALIAWTVKNQRVQIVRASQPIFLITICMGTTILATTIIPLSLDDGVLHEEGGCVDCECPGCDKACMAAPWLFTLGFTVVFAALFSKVWRLNKLVESAARFRRVTIRELDVIIPFGMLLCLNVIFMLVWTLVDPMYYDREQRCGLDESTSFGSCRLGRTGVSSAMAFSVAAVDFSALLLANLQAYKARQIKTDFNESAHVGIAMLGILQIFLVGTPLVFLVNDNPPAEFFVLTAIVSVVCLSVLLLIFVPKIMRSKNAPTGAWASGDFFGRNAPNSGMDFTPGSSQLEANSDPGTRPSSVLHNKSALADLPEQISSAFDPSAEQQIPLDQSENTKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKK6</accession>
    <name>A0AAD2JKK6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001991">
        <property type="protein sequence ID" value="CAJ1959299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="628" mass="70736" checksum="9F0AE6E3B08BD123" modified="2024-05-29" version="1">MGKSINAKASSAMTKKSGVSKMKTTPVAKKSVKKRVEIDLQQPKDRDPIDSKMVSETQTDEKRVMDDNEAQRMADEIESKRIAEREARRSGHYDSIVPNLSEWWMKNLYSGDAVDEALERHDRIHTGNELFMAWEERFPAAWNQPCLRYDDPFNDNTGTTTCEDRFSRIFTSMNSDNSQLTQYLIAAFDTETMEVNPSEEIWSLRILAMQISLQNPFSFFGIDEFEGKPDDNQFFSGEMSNPRLRLEHPLVGFWLICSKLFDYPWINEFLVEYYDDPPSAIVDAIKQTRSGKSINNAPNRESVKEPDPPCIQKIYDPMYSIDEPGTDVQRESTSSEGDQVQNPNRFAPLQSDDDSFEGSGIQDFDEVEVVAVKKNAPKAPELSAEDTEDDDTDDRENIVDDAMEEDEDDERVTTAGANPHDEAMDDNTLPLTSSKLKAKQDSAGTGTFMEPSESTPSRVQRPPTLAERISNLIQVNMEGIPGKCHIFETTFSVDYQGSDSGTVAEALLSTVLTSMEEAINNSPNELKLLPISDTTYKQLNLWIRNSVELRNRISTYRALSTYCDMEYGNCPYAAANSKPGEKKLAHAFASASRLRPRSRPSKTIFIPAYVNWGEALGATLLPCSMEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLG0</accession>
    <name>A0AAD2JLG0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042181233" evidence="2">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="193" mass="20973" checksum="816904DE1A10CC6C" modified="2024-05-29" version="1">MKALKASILASLLVQIPVSIAQSLRPEGVDVPRDYHVVNHGLNSHQQKVQQESSHPTLVVEGLGLHPPHISQHETLAFDFFTLPDAKEAAIQDYNKMSKKRAVHDWMISPASPRHSSKRGRSKPSSSSPSSESSSRKVDMSRISNAIRNKKVPTSTRSSVTAPSSSSSTSSSSSSTSRSEKSLSFDLSQAKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM38</accession>
    <name>A0AAD2JM38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS20223</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866:SF2">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="PABS" evidence="13">
        <location>
            <begin position="294"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1963560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="647" mass="71126" checksum="58824A22591F4048" modified="2024-05-29" version="1">MPKQEQEEAQPFKVALSTKFVVTSITASCAVAFGMGRLAKMTLTTPTAVASIKKDPAQIDMPTPIAPKGKEVPETIYTAKNFDTRKSATIFSQWLQQDPEDWNNVPEPINERLNETYEEDDEEHLPAGQHLLVDIDNIEADFLDSEERLATAMVDLVNGSGLTLLSYHCHGMVPSGVSCAGVLLESHVSFHTWPAEGVITLDLFTCGCTSLLDSMKIIENLFAIPRNGPDGDQPTVLWAYKRRGFKDQISDLPHNKPGSPRDTFAYPIGIHGQDYKKDVASAEIAPNKFAYVYDYIQRPHQDTALYMKSISNDGSYESKNPELFSPNRLFYYNGVFKSSSLGNAEAFESMVHPAMMAHPDPKKVLVYGSATGAALREVLKHTTVTEVTMVGVDTTLMQFARQYLPSWNDCSNFGLAKNCFDDARVKFVDSVTPSSKFDVVVVDTDFFEGVHDQEFLKGLVTLLSEQGVTVFHVTKDRPADMARVLPKGSKAFILDTKRTDFMTELESAGFGQTKEYKEKQVGFAEPRNHVVAFKGGALNWGLNEAQINRELVRRTAVTTSGVSALKFFDGAKMTTYSRFSNGKGGLDCISSPTEQVCANRAGIERQESSNNTGGDKQCGGSPQMPACKHAEYLQHVTAAAATVSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM41</accession>
    <name>A0AAD2JM41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA primase large subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS20177</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="269"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="447"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1963468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="483" mass="54510" checksum="EC30D73B476C914D" modified="2024-05-29" version="1">MNIVKKERSSSGLPKNKQSLNSSNGNQAINLYQEIPTMEVSLDDFEEFALDRLKVLKRLEQLKLRHVPAEKHKQYLDPLLSKLNNPEKDSISHFVLRLAYCRTEDLRRWFLAQEVALLKWRLGVSSGSVKNLKSVLPDAAKSVSQKEMEELDFELKTGTVGLQSLKLPLFYKVPFTLALDLVQHRQVFIKKGMAYIPESKLVHLVTSKFRAHLSRQLVLLSSVPTTPALKRTQGFLKNVATVHAVKDEFANKSEMAASLDPQNVKDHLRNMPLCMVQLQVALQTERHLKHWGRLQYGLFLKGAGLSLEDALIYFERMFTAKTKDFSKEYAYNIRHMYGKEGKRQNYPPYTCTKIIMSNAPNSNDHHGCPYKHNTVQQVSTMLAKLGISPQQQKPIMAQQQSGQFTLACMEHFKVAHPNAVTTPNVNLDNVGNHPNSWFEASVSYHKVTTGGGDEKSPSKTTTTTTVMDKAARGALKTPKAVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JML2</accession>
    <name>A0AAD2JML2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS20977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JML2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF0">
        <property type="entry name" value="CENTROMERE PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1965159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="370" mass="40528" checksum="D873A28BAD8323E0" modified="2024-05-29" version="1">MSNRAGPSDVNEAQEDDESDNKETRDVRAALQMAVLQIIIKEDRIHRTRTTPGAIRALSELVYQYVTNRLAPDLYQFSDHASRKSTIAVDDVALVLRKVPHLQEQLMGNLNIKKAPTNESNKSNQSNRRSSSASARSRQETAKSTANQNTRRPITTNLLSSSSSSNDDDSSIDIAKNKEKNRPIAVPRARSASTSPTVEQRKPTPLKTALSLKKAPPTYSQNKRRLDQLLNDSSSSEDELPDFMKPITKKKSPAKDLGSPLLPSPKRAASPPKRSHQSQVMEILNQYSSDSALSNDSEMAAAIATKATPAASKKPNYDSDDDSDDDILAHPSKKRTQKVVDGSSSSSSSSQEDDDNPGLPNTKNDDDDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNC2</accession>
    <name>A0AAD2JNC2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002307">
        <property type="protein sequence ID" value="CAJ1966642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042194689" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="209" mass="24208" checksum="B08A471338D6D410" modified="2024-05-29" version="1">MFVIVLVFVPHLLYLATQYNAPSPWTISPAVRPAFLAQQVIDSQGLLECCIASHWLPLQQQYFDKIRCCRSVSLWASRLFQQLILLGFYMWQQRNAIQHSDNNVQLHKRHCTVNEGIHSQFDMGPNDLPPEIKPMLSCCHRVLRKLLMDKEAWLTLLCQERRQYRRAMKAQVVFGLSSPPDPDQPFVGPYVPQIHPALSREKSFPPGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUZ9</accession>
    <name>A0AAD2PUZ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="221" mass="25972" checksum="E8D8A17FE011ED0D" modified="2024-05-29" version="1">MRTIELPDKSPPIWGLMMQLDELPFGEALNRVAKISDLLLVTENFHRYRFGHGLVVSKVFQTFTKMLLSDRLSVVQRIGKLIDLALMCDKIKLNGAKDSIVGFFRQALAWPQEEEKQYCGVIYRRKHVKLLVPLIATEGLICDRRTKEEILCPLFPKDYVSKMLRRGEKCRLRVIEKRMSRRSTILQGFSPEEVNRRNIMLLRAYRYECRLEWTFLIGLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV12</accession>
    <name>A0AAD2PV12_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV12"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="117" mass="12903" checksum="6D3C4AFACA64F869" modified="2024-05-29" version="1">MFPIILVSDAGLESVKSYDTKPNLLTQSEICFQKSGTLEEKESVITIKLIQGRWTICDKQIGPFGQDKLLLQEASTDSMLSFSPEPSSFWIGISGPSTPPYVLGIERTNRAAHARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVK1</accession>
    <name>A0AAD2PVK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS15862</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1955663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="73279" checksum="0962411E7AD81114" modified="2024-05-29" version="1">MSVTFTDSAPPFLKYQGSDSFFGGDAPLPEGVGWAVVVGFGALFSVITTIIVFIGQKYGGQGAVTSEHFNTAGRSIKTGLTASVIVSQWTWAATLLQSSNVAWQYGVSGPFWYASGATIQVILFGVLAISLKRVAPSAHTVCEIVNARWGRTAHKTFLFFCFCANLIVTSMLLLGGAATVEALTGVDYRWASFLIPWGVILYTASGGLQATFLASYIHTCIIFGVLIAMVFIVYIKTYSSDAIYDFLDKTVTYSPEECADIYAGYEAGKFACGPVDGNRDGSYLTMISSGGLMFGIINIVGNFGTVFVDQSYWQSAIAAKPASAARGYVLGGICWFAIPFTLATSLGLASTALLLPITDVEAGNGLVPPAVATHLMGDAGSVLILIMLFMAIVSTGSAESIAVSSLVAYDIYREYINPEATGEQILKVSRYVIVGFGLLMGALSIALFEIGLSLGWVYLFMGIIIGSAVAPLWMLMKWSKASGTGAVIAAWSGLILAVIAWLVTAQVREGEITIDTLGTNEAMLCGNLVAILSSAFIHVVYSIVIDPQEFDFTTLDEKITLVEEDTRGLEAEDQDIEMLQEAETWIARRGYVLTLVLIVIWPLLSIPAGKFTKEYFAFWVLIAIAWGFGAAIVIAVLPLIESSAEISKVFDGMRGKKSEEPTKETPAVEKEEPAAEPEVQEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWM8</accession>
    <name>A0AAD2PWM8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWM8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="572"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="650" mass="74534" checksum="9CA392B98BB9AF0D" modified="2024-05-29" version="1">MILTSTDKDTESSSVEYNGGQAPTTIVNEEKPQTVVTGEQSNDNGNQRLSVLDKVSGMFKISTPNVSIPKPFFPFSPQPPDEAPYVDAQLQVDLMESERSIQMLGAEVNMLREQLGYQQDDYLKLQNEMRSIANQERKLKEETRLVQQLEQAQQQQQLEKQYQHLKTTQQQLELAQRNITSLETEYQHRLAVQSKDFAHQQEQLERQIADLSHQLTTIKSALEIANQRWNDQTLELKQFQQAAESQKETMEQQIAKLETSLKEANSTNVQLQGSLSTSKADLEALRKDWQDLQTTSDEKEAAQIAMLESQHNETKLALQVAEELLKKTIVEQGEVAEETKKAWSLERQELESQVESLQLQLASEKTTTEKALAQYKLAQTELELAQKDKLQQLEEGQATADRLKTELEQMKAQYEAELESMAIKKDEHVHALTERIQTEHNRQEQELQDESAKVKAELAKMKLMYEQSEEARQAETKALEIQLTGQLETAQAKAARREQALLSQIEMAAVERVTKTKSLEKEIAKLQHENKALSSSLVFANTSRDESIEKAKALEQKYMDSGADQEKWKEQVSLMKQEFQDIQQSKKELEAQLVTVTLEKEELVLKAQALEANLQALTEQNAQLKLQQQHRPYQQRQKDSNDFHWALDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXX4</accession>
    <name>A0AAD2PXX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS23407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002406">
        <property type="protein sequence ID" value="CAJ1968799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="641"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1968799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1183" mass="132459" checksum="AEFB2E545B7B427E" modified="2024-05-29" version="1">MISNRQSNIRELHNDQRDTFASAKMTASSNAPSPESSNQTLEKVLEEKILKRVLAEIQESKDDTDSKIESLQLDTDAKINAILRGSQGTNNGDAANNNDPSPADDPPKFKLPRDVYSVLATASWSSVPFWFCGFVIFGFQYFLLILLLANQVDINSEDNPLNLPANVETPVRISQILLVAIALFSQDDLLVGIESFFDGKPDYYRGDLRFVSMPLVQWRLASVIRLVQGLLNLLAAFVLSIQAETIPDVLLNVLGVGFISNLDDLAFGLALKGYFGQSTKSLAKDVCDAEFHRNSKKDQNIDHTLVTKLKNSAHIMMAFAVLVVILFSFTFLSIAQNRGMFSEQDIQIEFGDELLPFLGLFNGCYKASESSNEQPSGRLVYEQVGYANGGKFGFCSDFGGGDGGWAFFIGEVGDICETFIVRSGETSTFSLLEAATTKWYTSEDLPLDYLEITEIKNPSSECGQSMLRKTIDACPAILDFDSIPMSRLPQRIDNMESRSILDASVSHPIYYYNRIEARSFDLLFFTGRRWLRTNSEHISTLAGNETSLSDIHDFFFVKDGLFTLINDLRTSPDSQTLWVSAMSGIVDVKRDQGSALGLQWYLPRYETADETSEGDNSRGYLQRNFPSADLTRPIDTVMTCLYCNKETNPCRYEGVCDNDSGICNCKHGTKGELCQIEPLENGVCDLFFNTAEYQYDGGDCCGGTCVGAQCGEDDRPNPFLDAMHLSNPLFFLGEPFFAFDDMADDWNDTYRGREFGFGMDIVNDDDLKFYFVPFRYEHCIDPNTALLLIQMKPVWYQSDMYKGLEFEGITVRCDGTFYLRMPEFTLNTVGEPTGTFQEQVRVPYGADCVIEFISEHGYMIDEVSVFAENEPEPFIKQRRILGSDTVPTRFQIPESTCVRNLFLENRFSISSFEVGEWNMPDLSFGWNEYMSEDEYTSFAEGGQIDAICKRDRDEVLERYVLWKIANSTIMDLSQNFFGHICDGLWDERDKGSLSLTCSGRRVNTLHVPTFKMEASQIEEAIKMLEYAKKLEHVGLPGIGNETLEAAAMDVLSTLPVLTSLDMTGASQNNLTSLPSKIGSLTSLQGLDLYDNQLTSLPSEIGRLISLTNLNLYSNQLTSLPSEIGRLTSLQDLDLSDNQLISLPSEIGSLTLLTRLDLRQNPLISRDSLPTEILSLDSLYLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CA34</accession>
    <name>A0AAD2CA34_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1894128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CA34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1894128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="748" mass="81492" checksum="90319632A35D6061" modified="2024-05-29" version="1">MSEMDNLSLSGGRKRDHAPRRRGPIGALDRRQALRTTLRRSKRKLVRRIRGKSAESDEKLEGESLIVEKNGSGGGYADSHSHGDGDHHDDEQESKPINEIDSDDDDDFLVPKEHSDHSHSGEDDNNNAQHDADDVEDEEHASPGSDHEEVHGDHTGSDFEEDHSKESENDDSPWGRYDDEYENKSIDNSIHDQDNSDYKNKEGSYRDGEDLHNNGRGYKDGEYRQDSGSPRSPRTNGGRRNSLLKQLGKKLLSPRSRRKTASNLDHTNLAVPGSADPYWSPSSPSRKRIEGFGSTKPDFASPRTLRQKLKDFRENRIAARKDEEDGMEKMNVGGDPKRKNWKEKIENVVDAMVDASIPEPELQGYMTSSTLAISTPQKSIPAAPPSTPTPANASKMSHDRKQFGDDNAYIVYLEGEKVANELEVLAYQNRIKELEFEARKLDDVSGEKNHGDDHSNGDRTAISGSSNAGGGEGEVKAVNEKESKVAGQTGVPKEGLLIDLGGTSTTSPPSIEQITAAVIPATDLVQTPQERQILTPETNTTITSQNNGPIPTSPTEQLQEISAEASAEAMKEQTEGALIDLSVRNEAKDIVDNILADLLNEKKVTSLQSDDEGNVADALLSLKLEQSSEKVENTTPRPESSHAATLTGQEGTNTSAPVSTSLTATNTLEARTNDAGEPIPVEESSDAPPKSPADSPPQRATGPPPESPADIPPEPPAAETPENLKDFKGKEEEGTVAESAEIEHDSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBG4</accession>
    <name>A0AAD2CBG4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS1018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBG4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1923224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="152" mass="16948" checksum="75F1E45AE372E2A7" modified="2024-05-29" version="1">MSLLRYDPFTSAFDDGFDRSPYYRNEQSLMPRRSGWQPSGMTSHENDKNYVFQVDLPGVSADDLEMKLDDTHDGHTTLHLSGGRQFQSKDGTSFETSSFERQFSIGSSNVDKEKIRADLKDGVLTITVPKTEEPEKASPTYIPITSGAAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCN7</accession>
    <name>A0AAD2CCN7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1914752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCN7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="450"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1914752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="601" mass="65841" checksum="835D85A2890FB13B" modified="2024-05-29" version="1">MELPFAVEPSVDPVTSSHLQESASSTLINAPSDVSSPDSRHLDGLNTPQDVFVPRYKEKQPEIGTRVFNSEANDPNDGFVDPEITDFTYVNVSDTDVDGLHAIIDDHELYFEAESQRSDVLGLLLSGTNPIVDITDEANKAASKALEAKKRGDLLGALEYHTLAARKYKENAINNPSFAKPMLLLSQTQAKSAIALKKIIQLNPEELIQALSTSDDSLSKESSAISHKDRLRAAVRGALGSKNHEADISDSQFLGRATANPGSYDEAKYSEVEIETSAPVGADTNNNPVDDMMELERELRDMDMALELGSSISSLDTRMQNRMKSSVVDGSFMVVPPGSNSYMSSSMWGGGPNPRSSAPQSTSANVNVRARANRVQSVMGASTAAPVARLAKPVPPPATPTDAPDGLESSWWGNANSTSQMLASSVISLGTRVDSGPSIDRGQPINTKQLMQLMDSLKALGDENAELIRQVDDAEASRREAEAAREQMKRFKHDYGKRFASLKAALDKFRQDYPERGVTSSENPMNSSEFIRSSSTKDQIQRQEQLIRKLTADLKKEKEESKKKDAALRKYEAFYREVKARSAQKKTAQRKTESQRTKHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD46</accession>
    <name>A0AAD2CD46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="14">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CYCCA115_LOCUS1939</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="14">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15 16">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="14"/>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="20">
        <location>
            <begin position="387"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="19">
        <location>
            <begin position="1058"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="930"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="610"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="active site" evidence="14 15">
        <location>
            <position position="1155"/>
        </location>
    </feature>
    <feature type="active site" evidence="14 15">
        <location>
            <position position="1198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="769"/>
            <end position="776"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAJ1930434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1250" mass="139468" checksum="F0F164EED4ACB4BF" modified="2024-05-29" version="1">MAPTDEKLQRYRLIVSYNGTQYQGFQRQNSGVVEARPNKRQRSEKGKKTKKTKSTIQETIEDALQHLSGLDRLALKVRFSSRTDSGVHARGQVLAVSLPPSLCPEFWQLRKSINSRLPKDISVDDVCACLETFEPREHVLWKRYSYTLKYRRKVVKDDGELLPICTSGPNTIRNGLDPTAIWVVPWVLDDSKLDEYCEKLIGEHDYSVFVHKHARRERENVLTVNRLFCTTLNETKEEAPVVTVRLDVEAKGFRRSMVRNLVGFLVDICMGSVDETIFEEELWLGKDDTAAKLNMAPAVGLCLEYVQHDETKWKEGAMEGHKVLTQQLAMLRLAYCRQVGRQPRLLESTVCSVQTRCFTHGDKSNNSSLVVPTKLRFGDEAPRMPHALALPVTNRPLFPGVVTTITLTDPATIDALEALQQDQQNSYVSVFLRRTNPTGVSEGGVLLPLPEVITDPSELYDVGTFAQLSRLTRKLPSPDLDSETTDEEKSDDSATALLLAHRRVNLVSVDEIGPPIDVTISHWPRLEYTGADDTIRALSNELLSTIREVAQLNVLFRENVQYFSQRLDANDPYRLADFAASVCSTAKAEDLQALLEEKDPEMRLHQALVLLNREREISKLQQEISQKVEEKMSETQRKYFLNEQLKSIKKELGMEKDDKESVIEKYRKQLAEYPEIPEEVMSVIESELEKLSSLEMNSSEYNVTRSYLDWLCGVPWGVLSDENFDISRARKILDRDHYGLEDVKDTILEFIAVGKLKGSVQGKILCLSGPPGTGKTSIAKSVAASLGREFYRFSVGGLGQVSEIKGHRRTYVGAMPGKMIQCLKTTGTTNPVVLIDEIDKLGHGYQGDPASALLEVLDPSQNSSFTDFFLDIPVDISKILFICTANELERIPAPLLDRMEVIRLSGYDFPEKVAIAEQYLVPKSMRDSGLMEEKTPAASEAEAEGGSEDTGSCDEVPKKPLDSFQHVEGVPETVGIAPDAIDNIVRWYAREAGVRNLSKYIDKITRKLALQVVAEKEGTQLSKKSSKKGNGWMVSEENLHDYIGKPIFTSDRLYDKDPLPHGIVMGLAYTSMGGSALYIETQGIQRGMNDDGKPIRGGSLKATGTLGDVMKESSQIAYTVARARLAMLDSSNNYFDNMDIHMHVPEGATPKDGPSAGITMVTSMLSLALGKPIRNDLAMTGEVSLTGKVLPVGGIKEKIIGGRRAGIKKIILPGANKRDYEEIPDYLKEGLEVCFADEYEQVYEQVFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE35</accession>
    <name>A0AAD2CE35_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS2491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000169">
        <property type="protein sequence ID" value="CAJ1931666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE35"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1931666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="596" mass="66110" checksum="6919185B06199ADE" modified="2024-05-29" version="1">MALASFLRPTDSPRATSFAIGNATTCSISGFMTTAAHSGTFYTCMLSYYFLFTARFGLKNSVVARRIEPVMHCISLGYPIISAIVGAYYEAYADTATYFGCFVNCPPGTNKEDCIATTLGWIFYGWPFLFVLASLIVNNLLIWRLVHGHSVTLRKMHTSRQVGGSSDESSAVHSLDDDISSLGLTKRVDATVHGSDITSSSYKANVVYHRKVTHVATASHLRRLQLVKSQALLFVASYAFVSMWGGIMAIAEQYAHTEDEELSLLVKMYPIMVLHALLAPMQGLFNMLVYVRPKYLTTRHEFGDQSRWWAMKRAMLGEKRVRASGKPNAPTALPQAMKQVPDAESPKDGVIDNRIDSVDVQTQSLPLKRGGVSSLTANSGSEFHDEQSYEENLNDEEQDRWGGKHHDTWTPIKQAPRHCSSLLEERDSSLGMISELTETQFEPIIDYSVETRFEQDHRFETQQGDSTPAPPRPAAVLSPSTTDSRWTNDSAKERQLISSLDWMMPQRLSSTTEMHCTEDPMGGPSTDVPLQTPMRIESLELISEIEDEGTDDVSQPLPPSALAGPLGVQASSTADRTLRPPVRRTSPTLSVRPKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CER7</accession>
    <name>A0AAD2CER7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS2427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000158">
        <property type="protein sequence ID" value="CAJ1931526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CER7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF38">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="257"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="8">
        <location>
            <begin position="712"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1931526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="85070" checksum="92AB3909137510B2" modified="2024-05-29" version="1">MAMTLDPYEQQYQQYFGTAANGSSKVNIKQNEDSQTQQTPVNDPLQASDTAAVIDPYQSQLDQYSGQLASPATALPQGQTGLQLQLQQPSDSNPPSMNSWDSASSSSTTTTMDPYELQYQQLCSQVSAYPSAYSSESPVPSNSASPTNGAGYPSQQQPKQQEIAIPVPEPAPVVQSKQEEDDEEEGLEDKFLRMVSSEVAYKKLKGENPYALTDIDVSLLIQRFLDNIEDSTQKNNGKTKGQSKLKGKTSPKKGRKKIVVLGTGWAAHAFIKLASTYDLRVVVVSPVNHFVFTPMLASAAVGTVEYRSMTEPIRVTNPHIDNFVEGRAIGVDVVNRKIAVQLTKLSTVTNTFKGLASDAPSRLDPEPVLTNIMYDEETNVIQRDAAIQGAGDVIELNYDHLICAVGTGARSSIVPGAKDYCFNLKTSQDSKRLRTAIGEALEFASRPDVQEYYYANEEDKMIAKNERQRRVRIAIVGGGPTGVELAGEMSDFFEQVCRPSDGAFQLLKDDISIMLIHGGAELLPAMDQELRNRALVALDEQGIDLRLNSRLKEVGRDFVKIFEKSSGEEETIPVGLTIWAAGNAPLPFVAELLSQLPESAAGPGGRINVDEWLRCPTPSEDSFGSVLALGDIACLEAQGKYDIEAKALPQTAQVAGQQGAFAARLLNRGYDLQQTPPVLPELTAEEGYSILRLWLIARGLDEAPGFAFLSLGLLAYVGQEEALNQVTIGDVPLFNYSGKIAYALWRSVYLAKQASTRNQALIVFDWLRTEAFGRDITRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFH9</accession>
    <name>A0AAD2CFH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="343"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="447" mass="50870" checksum="7DDE9FC4EFE066C9" modified="2024-05-29" version="1">MDSLIAHALTSLSFDERQRQQEVLHGVATEIPENAQMLSEAFETLHCHLEKIKRVGSSYQMAESLDVSYVSDKAFRLMFLRGNRFDAKAAADQMIRFFDMKHQLFGRDKLTKDITIEDLDEDDLAFMRAGSVQVTETDRAGRPIWFALPGLRAFKCLQNELRARYYMAMELLKSEQAQRRGIVSITYAIGRYRDCMNGTGYVELVRQVLALPFHKAALHNCVSDPKEYILGSAAMAVIPVKDRSRIRLHLGSHMEIHYILSTYGIPSSKLPLHPKTNDAILDRHMRWYNDCLARDTGGHQFVVEKQMDTIMSDTSIVEQKQHHFASAIGSNDPMVVERPGRNDVVLGRNNKGHGNQLMMSLVKDLAKDYDSAGRGEKWTIADSIVQRIREQGGRFLQQQSDGNWEEVANDFARSKISKCFRNHRRIKKKNGGSSLDLTVPIVGDFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG42</accession>
    <name>A0AAD2CG42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS2488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000169">
        <property type="protein sequence ID" value="CAJ1931660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041990311" evidence="3">
        <location>
            <begin position="19"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1931660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="555" mass="64559" checksum="B518E9F10B4595BD" modified="2024-05-29" version="1">MKVFHLLISLLFLARTYALSVLEPWPNGTKVFYYDKSYGEWINGKILEYDRQTELYTMKWEDGRTEDSSRFNDNDLYNMVENYETLWPIGTPLYNSVNATFGTVADLTQFGSYTITWENGDVENDQHSLDKVDTMVKDYMVYHEEAGLIPLGTHVYYYDEEDKKWDMGKVTKWTSTQGYTIMWGDNVTEIGLYTDRVMHDMVNNYKSKTAIESDEPIPEGTGVYDYDHEAHAWYKGTITKQSPQLGYTIMWENSAIEVAQYSHDEVRQMVLNFMNKDLISPDTEIIPVGTYVEQDGAITRIGHIKRWTPMDGYTVYWEDGSIDTKTYTKVQIDSMMRAYHNKNTDHWPEGTRLYQLHNNIWREGVISDWSSQTSYIITWKDGTIENNAYTGNEMNEMVKFAHLYLSEDSPYVGNSIAVGTPVFLNYDDEWYEGVITAYEPKEGYTITWNHGTEETNEYSKSELDEMIDNWKTKRPPSKYGPWVSSNDTNPMYGVLIFFCFLAISGPVLILFRKYVLRLRDEREIQDDDGEGEIMFQDPNALPSDPKLLPDAKDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI45</accession>
    <name>A0AAD2CI45_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000054">
        <property type="protein sequence ID" value="CAJ1928577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI45"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="306" mass="36038" checksum="850BE184AC1AAA73" modified="2024-05-29" version="1">MLQRIKRRQEEEDEDDMDFVQDQQPENDIEMDIDDEELKDMIDEVSLELDRLSQPIEVEIMFSVEDEDDDNESEYDAEEIEELQEAEDEPQVYPDKEDDVRAGVRFEEVPVPRYGQTYLQRKKPKINLLKNRSAMRKKARLKRLRISSYQAIASKVKSRKKGEFRDDNVLSAETRRKITERAHNLMFQQSGTEKKATYNVDESLVISRVMQQIRDEVYTRDGVSFIQQYYLNKGLKIFKERGKEAALKELDQLIKRSCWTPISIGELTESEKRKAVDAMMLLAEKNSGDIKGRFVYKGNETRDWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJG9</accession>
    <name>A0AAD2CJG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000302">
        <property type="protein sequence ID" value="CAJ1933794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="354"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1933794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="580" mass="65770" checksum="00F50E73FB7600E8" modified="2024-05-29" version="1">MHRWNKNTIQSSQSQESSRPIAFEASAPSSTNSHDSASTSVDPFLLDFGTSINVTEDLRREIRSEIQEIVAKLAKGTQAHQQEQRLQKQLQQDLHHTFCEMRNLSRGAADRLEDAQVHSSFLNGLDTTLNTDVARPTGVLPECRKSPVSVLDTLNVTSLKDPPSPDVSEGQEKSGSSKTNQEVLKEKEEMLKQLVQSIQEQTTQGDKLRNQNQNWVMEKNRTLERIQSEGLVAVLEQTQQKNQHAHVDVQNESQRRDQLVAKVQSVRSQCGNHAQQLADKTKEIKALRADNEVKQVDMKSKVANAADSLSKQKEELGATKSSHGLVKSRMEELKQQEAYYNDFCQARKTHEETLRTEQEENGKLLQLLETLTAEQEKANQELEESKEALGNAQQLHDKVFKKKAENDRLEETVMKSGEEERSRLAQEKEQLATQIGKHHAALVQAQNEQKETLANKMETKNEVSLKVARLESELKEKQDEVKTRASARQITKGMLEQELQTMIDKEEQIRSEHKTKMETLQAAHQASQVAAKQALEAAKEKAKLQMAKERRFLETIQIGAKIIEKANEKEEKLNDDIVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJY5</accession>
    <name>A0AAD2CJY5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Na+/H+ antiporter NhaC-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS4363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJY5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43478">
        <property type="entry name" value="NA+/H+ ANTIPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43478:SF1">
        <property type="entry name" value="NA+_H+ ANTIPORTER NHAC-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042225620" description="Na+/H+ antiporter NhaC-like C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="642"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Na+/H+ antiporter NhaC-like C-terminal" evidence="9">
        <location>
            <begin position="291"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="729"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1935026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="758" mass="80781" checksum="C6B2E37D230EF0AA" modified="2024-05-29" version="1">MLQRLALLSLLGTSAVAAFDYDIVGAGSVVLTDVDTGISDLRTIFTDDEIAVSLDGLEWESNGGNTTDGLLFYKTYLDGELMSEGNMTLGDVGRELPSGLDAGTVKATAGGRHTIEVIVTSGEAEAVTDREVESYAAGVSILPLLVILVLSVTTNMVELSLFSGIFVGACIVAGEINQGFKDTVEDFILNALADVGHGYVFLFTFFLSGLVAMLERSGGMLGFTRYISQYATDARRGQVAAFVVGVVIFFDDYANTLLAGQSMRPLVDSLFVSREKLAFFVDATAAPIASISPVSSWVGYEVGLIQDEIDAISERFGGDITIDGSGMALFLASIKYRYYPIFMLLLIIGLIATQRDFGTMLIAERKTEVYKRTDGGDGGTSGAAGSMGDENAPRQDQPLKTYNFALPIIVLVFLIFYTLVQTGDDGSGEQDFMDKIESSDSYQALLWSTIGTALVTLIFYLVQFTKDGSLIVPSGSDIKDAFFGSSEESDEPKARSILSVRDSLESFIIGMGRVFPACIILTLAWASGSLMKAVGCDRLFAAWIVGGVDPSDLPTLSFLISLFMALATGTSWGTMGILFPLIMVPTYIASNGDEEIFTATVAGVLSGSVAGDHMSPISDTTVLSSLATECGLMEHVGTQAPYVLVVVIISILFGTLPIGKGAWPNFVGVILGILVLVAFIFGICKPVLSPTGAWDPITLLFQKIAKTEGLEKLQKDTIRAASGEDLSKEVEAKKVDVEETPEQSQPIMEKPSAEEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKM9</accession>
    <name>A0AAD2CKM9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000574">
        <property type="protein sequence ID" value="CAJ1936915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKM9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="201" mass="22239" checksum="62E823A7A0F77131" modified="2024-05-29" version="1">MKKYFVEKSYKFALGACVRDVTNGLAGGEPGSCQAMMEVATEIANQASAPSTDSDTNDDDAFIQVRSQANYKSHKDEATAMRRLEESEFMSGLVVDDHLYLVIKTGGMNTYFEFHLEVCGAQYFSYTTVASSGLESSRFKSCSEHFLLLPLLNNDGSVPKGKGRDGERNFFYVITSGWREISRSDRAGFVLRLPTIPGATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL32</accession>
    <name>A0AAD2CL32_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000491">
        <property type="protein sequence ID" value="CAJ1935624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL32"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="170" mass="19431" checksum="CB5D05B214D51D7C" modified="2024-05-29" version="1">MLVGHPSENLAIKHAILLLIQGVRDPSLPSLRGVPGCLCRAFCSQQCIGYQGLLEGRLSCQWAPCRKNTYSCMGGSSPTLWVSHLSHQLILMGFQMWEHWNLVQHLEDNVQLREHSRQVNDGIHSQFDMGPTNLPKVAQRMLLVKRRAVLNKPSKDWEEWRKLVKMEHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLR0</accession>
    <name>A0AAD2CLR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="658"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1237" mass="139444" checksum="A08E99BCE0A907F7" modified="2024-05-29" version="1">MSQDSSFASDALAGLSGPSLDVLETPVRILDEDSPHYQFLETHMLPEMGKLLKELRGRRFKDVQLKLSEGIRSLKEFQYVQWPEETTSSKRSQLRSRQSALEAHLEGLPLDSPQSSSANDHAFHASRDSLDSFMDLHSVDGDFEGGSTDGILEDDFGDNDMEKDDATSFTSLSNETPPTATSSLSDGDDPETRDQMHESIRTSLQAFILVLTHPQKTNRSCDIALECISQLVFRRYVSGRAGGRDDDSGSGSIHRETPPAHRPPNSLMHDVIVAVQKCGESSSETIQQRVIDCFEAIMNSSTCSVHELTMLLFIRRLYHIYLSTKSESCQKNAKRALMDIVSKTIQRMEDSPNAKHSLYYTDSYILMKRVVHLSAKALPGVDDEKVISKNVLNKQIFNNDAVDPKALNNKELSLELILLMIEMAGENIKTAQKFVDLIQSQLCVTLLKNCISNSTQVAYTSQRIFLVLVYKFKKHLKEEIQVFMKNIFLRVLESENSSFSQKAIVLESLRSMCHDPFLLTQIFLNYDCDVDGMRIYNDIVTNLGTVAILSTKEPSAGEDKELEEELTLGFAAVEVLVIILNTFLKTMGLEKRRHREMNDMAGKQIRKLLQLKEVGRLLQEMEEEEDDEQEPEEKTLEEHMEDPDIRASIMDQTDTLRQMVNVFDRKRNAEQSFELGAVKFTLSISGGLGFFIDHDFVKLDAKEVANFLFENREKLDKTQIGELLGKEPDNAYDKTPGVEAERGGKGFYLKVLYHYVDATDFSDMLFDEAIRLFLLGFRLPGEAQKIDRIMEKFAESYARQNPDVFSNSDTAFILAFSIIMLNTDLHNPSIKPSRRMTLESFQKNNRGIGENGTNLPDEFLAGIYQRIKKAPFSLKEDDALREKVVAETSNGGFFGKSAETHKKERFDKEKEEMMSSTVELILQKREKAGTNDKVLESVKPAYVVKPMFDATRSSLLKTFTTIMEGSVVRSNILVCLNGWQYAIKLACNKDMPEAQKAFVDKLGELTLFESLEDLNFKHVDALRTLMGLAVSDGEYLGEGWGAVLRCISRLATMRMKAEEILKGSNSQAFVKKRKSFARRFYKTRAKKEAESEESKEKESLMKLSILESVGDQLIDNVFSSTVDLSAQALESFTSQLIAVSMEELAAGEGGLQFVTDMEKIGKKTLETIASEDEFSYHSSSGELSYDASYDDTKSHDGTRSRGESIDSADFSLGTTDDELDLTAEVERRVDKRLKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMB8</accession>
    <name>A0AAD2CMB8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000036">
        <property type="protein sequence ID" value="CAJ1928136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMB8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="184" mass="21158" checksum="35EF9FACD07B5666" modified="2024-05-29" version="1">MMTATKLLMTRNNIKILHDQKASRGIYYFRSHFVQKEEEKTVQSCPFFAPFLGIPGDSGGAIKSVSDDEEDRAIRKVSSARAPTPMDLQDAVEDKPFQHYADKFERSLKQTYCNNPTLVDLLLQGNCYLVHHPSVNWQMPQFDFPLWRFKCWHHSHGQLGKTPLICSLTKPRYKLLALTLFASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMJ4</accession>
    <name>A0AAD2CMJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000393">
        <property type="protein sequence ID" value="CAJ1934829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="265" mass="29058" checksum="6C5662A721AF2460" modified="2024-05-29" version="1">MPSTTPADNSFVTPSKTVDFSGENPEETDNTVDENVAAALPPVVHDKFTKPEALLITKIVFNKENPTKPMFDALQTFFDHIGVEKPSDLEGQDVDDLLSHGENALPDGGLIRGVITGRLKKFLLYASAPSVAIDPSLTYQKIVQFSIDQAKQNIPTTPIDLTKAIGERQGMKFRCPEVEPFSGESTVYWPWTSKVALEFGQSGIELALTDAKFHEQSTWHKDASSQGFYAIAKALNDGTASHSHSPCVFCSFFHVSQGVIVKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMP5</accession>
    <name>A0AAD2CMP5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041897384" evidence="3">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1937732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="264" mass="30157" checksum="EC3B18CDC463E0F3" modified="2024-05-29" version="1">MMKQLLSFGLIALLTCPNVQALLQGNAGTTSSYRLAGTALQVSRTSPDYKKKDVSSSEGESEAEKYLRLARKLRQQAAEDEQQVHERLYQKKREEDEQLDEWIQNLSLSEAVDQKKNAHIVNALKERKPCMETLERIVERLHEHHMIASGLECVEAPSSKDASQVNRVIHEKDDVKVQKIDNEAEALFQAIDVLDSDQSGASKSESRHWGGDGRAIQLRNQWKGLQREHEDQFLKRQASFIEAQRLKKENPPPPKVKDDHRFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN74</accession>
    <name>A0AAD2CN74_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000904">
        <property type="protein sequence ID" value="CAJ1940552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN74"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="164" mass="18297" checksum="CA437EF057DCBD26" modified="2024-05-29" version="1" fragment="single">MPQEVRSVSSKVLRGIVPFLIHHLCKLTNTQADRVLGKWIPKSEIQATRRKCLVWCTNTLRAIEASDQSTKVEEALEFLDDVIEDTTDVYQGQLSINMDMANAKDIDDGQTVTGMLDEMHEREQQLEDAFVEIEARDNALAAKDQALAQQKAATAALQAQLDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNV0</accession>
    <name>A0AAD2CNV0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041962447" evidence="1">
        <location>
            <begin position="22"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="343" mass="40158" checksum="20A95AC752180383" modified="2024-05-29" version="1">MTIRKILGIPWLIVLFLNGDTLVDLLEQCIKDNYFFMTWWLESDYNAQLYYRSDRAVFIFARARRAKKVSMLSGVDGPDKETRARRKLSKSMVRDFRRERRDLEALEFLKACYEEGADLSWPDTYGNTVLSVAIRRCYEQCVKWLLKHHDADPNRQDHYEGNTGMRILVQRIGKLGDGTAAAMLRLLLNNNASDFTTLNFHGDRGIIKNFNKLTKERGHTPYMMLRNPSKFPDSANALKPRPSFQQLEKLLKTENKSARQKCDDVYKLISESHNGDRSLHHLRVMDMLFCANEGTNEDLELRRTTIFNHFLKQVLLLSTQDSSEEEKLTHDDVALLWWMYYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPV1</accession>
    <name>A0AAD2CPV1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPV1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="203"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="276"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="353" mass="40131" checksum="937FDDC2B7C10185" modified="2024-05-29" version="1">MIQSNLNFSTSFMNPEQNSAFTALGTSSSCPKSLLAQMQQAVQPSHPPLKKRDFTLSPTNDSEEASQPSKKRRVAVGMGSWWKFGSMPTEIKNLAKQGSVKCKPPSSGSTQVTTMDPRPFPPATIQIRTAMPMSLPNQVSQVLDNSITQFNTAQLEAAQARIAAVTQLAVAPTTPVAPVVERSDHDSVSDTGSGGLKYRQYQAENWSERYESLIIFRKNHGHCLVPNSYPEDVALAQWVKRQRYQYKLKQESKRSTLSDERVEALDNIGFVWDSHRAVWDERFNELLDYKRVNGNCNVPSRYTENRQLAVWVKRQRRQHKFFRTNQPSSMTEERIIRLESIGFEWDLRSRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPX1</accession>
    <name>A0AAD2CPX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000746">
        <property type="protein sequence ID" value="CAJ1938624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="242" mass="27733" checksum="4B53CD9D8FD0F8E0" modified="2024-05-29" version="1">MISCPKVSVLPVTDQVIERVEAWAAAEGVTSMNFFDKKRDLETFQDGDQIAGVDDTEQGYLEEAFDQDYEPEDEDERGINLHGQFDDIDDSKREELLADADNDVNDMPELTVRFQGDDDYESDDDNSGDEGNDEEETIVADLDHHQENVDRGTNDMGPSLLIWRTCQKKRLHLSLKSLKWQKSLDLMSSHMDPKVNDKFAEWLNMRYGSIKACTIVRGKIHRYLGMTLDFSVKGKLKIRMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQC4</accession>
    <name>A0AAD2CQC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS7996</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1942536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="620" mass="69535" checksum="CF4FA02F6421D5BF" modified="2024-05-29" version="1">MSDDPTEENLVDVSATFHPTAYDGYALIDNVSTTNGKKKLLNEMNLLFPEGSVSAILGPSGAGKSTLLNVLTDSLSSNSKAVADIHLPGHSSFVPQDDQLHGFFTVKSYMHHYAKMANLKLPRKELDAKIDTLLKQLGLTEQKGTRVGDIFLKGLSGGQKRRLSVALEALTDPMNLFLDEPTSGLDAESALQLMEFLKSYARAASGRRVILTIHQPSTFIWQLIDNVILLAKGKLMYEGSRKSMEEFFAKYEHPTPHGWNPADHYVTMVNDEFRDHARSVNEWAQSYQDWQKNHHLGGPKSSAFFSPPKRSGKERTTSMNAATNKGTVDTKRSNSFMAVGPLLYRYFLNLWFNPGILGTRIAMYSMLALMVGGLFWELGDRTDYESIISRTAVLFYCVAFFIFMSVAVLPFTVMERGIVDKEVLNGYYHPIAYQVAQGLSTIPAAGVLAGLTSVIIVFMLKLNDGWWYFLNMFLALCTAEALAQMVSHVVPHFVIGMAGIAGLFGFFMLFMGFMVIPSDFPYGLGWTYDVAFHTYSWRSFMVTEFQNLTFDDPRSPFATGHDVLKFYEIEDVNRWNDMIVLACYAIAIHLISFMVLVIRYSYFKGKITPLNGKKHPGMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQX0</accession>
    <name>A0AAD2CQX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Inward rectifier potassium channel C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS6939</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF103">
        <property type="entry name" value="POTASSIUM CHANNEL INWARDLY RECTIFYING TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="105"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="378"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1940232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52714" checksum="C510EF69E60400BE" modified="2024-05-29" version="1">MPRHSNSDDGTDQQVPTGSSPQDQGLITPLLSHAQSIRQTSSLRQRRELSSNQRLLDRDATFSQSHGRWGVQRLSRLQRRWCLSRIWNDGIFGDWFHRLAYQKTWILMGILFVTYASMVVFFAFVYLGVSILGSKTEVGPDGSKKVIAFCHMDINNHMEALYFSLSTMTTIGYGVSDYYFGGCWTPLLLVLWQVCCAITFDAVAVGLLFHRISRGTKRGKNIIFSDKAAIQQVNGVWHFMFRMGELRQYHLIEATVRCYCVKHERWPLSATNNTIELNPDAATNDNPNSSTEINTTYFVSRQMKLKHPDEEYGSHLWMGLPQVIVHRMDSQSPLVPSSQTWYDEQGMEHSTPSMSPQEDEEQGSNTTIANSLEDFWWDRNVEVVVLVQGVDEATGATTQARHSYKASDLRWNHTFVSCIRPAPRTTRRSSTRQSMAAEVDFSSFHGMLPAPIHCQQSPFIPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR71</accession>
    <name>A0AAD2CR71_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="609" mass="69118" checksum="3DB120AE92E87F5A" modified="2024-05-29" version="1">MMMQSVISFLFPPKPGESKDLPIEITALPGLITFLDVALFRANEGQLTATTCSSHALLACWLDIKHQSQLLLQVLQQEKKDPNAKLECESFCRQCLETAMDAIERLSTDRLAQAANLSDPFESISETAGGHYHHNHHNFLSGIGIQGVSSGILESKEDIGRRLPSQKRIDCWESPRLHCPDYVWAEDSYQACQRWLRNLYKHPFYLKDRDALNPLATPNLQNQGTPNSNNKNSNEQPLHPPSERQASILIQLIQDDLPLRLLQFRQAMNAEEVVTKRLHLVKCEYRGPFRHFLEAHLSLLEAPSMDVVDYFLDGDDISYDSEVQEGQLQDLLETPELVEMLTLERDCEQFELDLGKALFPFSELARTLDHKKARIKAVPGVVEEDEVAELQETVRRLKCILCRKSGPETSTGIRPILVDLQSVRRDDEALKSFDDSRSIKENVADFLSQLECLSTLLKTRNAFRTRRGNHVIEFSASVVNGCTEEFDPELVECQLLDWFDMVERQQELGQEQQHIVSNIREVETKIGLADASDESLDAAKDNLEYMVDDRQQRLEILQDLVEDLCLREMNLHILINDPDPEETLILKETSALGFLGVPLQLAGEALPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR79</accession>
    <name>A0AAD2CR79_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS6928</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR79"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042130188" evidence="10">
        <location>
            <begin position="16"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1940210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="234" mass="25062" checksum="A33FFFDC6F730AED" modified="2024-05-29" version="1">MKFTIAASLMGMAAAFAPLDTTVTRTETSLNLWGEPTEKDGEGGEKSKALPFAPRPKLLDGTLAGDVGFDPFGFAGADKESLIYMREAEVKHCRLAMLAAAGWPIAEIFDKPIADAAGLPSLLTKTGESPSLLNGGLDKIDVAYWAAVVSLAGIVEIESAKMKEEKGKAYIIGDCNFDPLNLLPEDKAGQMTMMTKEIKHGRIAMMALLGYVIQEAIYGTPVVQQTPFFFTPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSU4</accession>
    <name>A0AAD2CSU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WDR5-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS8987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="33"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1944631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="361" mass="39507" checksum="6D506F7839188936" modified="2024-05-29" version="1">MSSPSRKRQHEDDDMDVEGETKHPFKCLPMYGEHKRAVSSVKLAPSRLTKEHAALCASASADGSVKIWDLGASMDDKTQESLLQPETTLLGHSRGINEVCWSNGGDPFVATASDDKTLRLWDAQTGDALVEFRGHDNFVFCCEFNGPSNLLVSGSFDETVKLWDVRSGECVCTLPAHSDPVTSVSFNRDSSCVVSASHDGLIRVWDVCTGECLKTIFAAGNPPVSHVTYAPNGKYVLAGTLDSAIRLWPIGVSGKAKCSKTYSSAFHNNSKYCIVSKFMVAQPKRRQCIVTGSESGHVVLYDVHTTKVHQVLDRVHKDVVLAVDAHDKMELLASGGMTKDRTVRFWAPEDESASLKKLRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT01</accession>
    <name>A0AAD2CT01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001391">
        <property type="protein sequence ID" value="CAJ1945377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT01"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="198" mass="22088" checksum="E3DC172F2F82AA65" modified="2024-05-29" version="1" fragment="single">ARSSIQRVTIVNAGSTVGNSEDLSVGMTSLFHLEKSTFASSFLVALTSTSSSESQSSGPSNSARVSPIFSDADIRFCFSFFDSFLKEVSFKLRVISAIPRFTETPVGGSFSARPKPSPYPSINQDRSQYEKRLYSWLSIQWVQASPMYPYQLCHWPQNKPWWEESAMGAVESTFDRLSCRPVNAQKLWSALPTHYASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT15</accession>
    <name>A0AAD2CT15_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14640</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9523</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001391">
        <property type="protein sequence ID" value="CAJ1945379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001851">
        <property type="protein sequence ID" value="CAJ1954045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="942"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1390"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1954045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2046" mass="229619" checksum="C87ECE5C8C567CF9" modified="2024-05-29" version="1">MSSTSGGTPSTGTLPSYITKPTCGGITTVGPNEYEIYTGGKPDDTRSGLDSSAPTERVYPGQTRPISGYRSMKSQTYRTTFEGTTKISKTSQQTKLKRDLHQHFVENGLDSITYLPDANGATTSVILSADSFSQETALAAYKTMLPKYDKYCIANDKDAAKYLLNAVDDDLKDTIELFHTESDGFIAVWFSLLANITDNNIDRKKSLEDEIKSITVSQFPQQNLKSMVAKLKPICDELDAMESYEPDNSIHMLDNFSYAGSGTDPSNPHTMRFRSKIITLRDKLDDAITTCRNMSKATRDTHLKGQGLHYTQLLKTISDIYVKLEHNKTWPPSMTPLDSRTPAALNMAALKDSLSPSVAAQFEAYILQQSKGRQPPDEDKKSTNPKHVPPTPSMTPTETIEGIKHYVQDIKGVKNNWCGRCRRWTPTHWTWMHGRKPDDKPTPVTPASTESHLLINKQDSSGSDDDTSLETNLASSGFKYVFYHMELPRPTPAKISERISSPEILDEAPSSSIMDKSYLWSYLWYTFQVAILGFSLFGALLCTTTTIDALPGLSALSAFFQDIPRLVDTYTFTWHAIAPLLWYLIYSLLFIGPDRFAAPTPVPRHIRRQIQRHLFRESRRKPRGIQKPSFRHPRYQPSRADCIRRFHATTTFFPSSFHTVSEGEPAFPVIWDSGASVCVSPHLDDFVGPLGPPPCSSTKGVGGPVEVKGTGNVKWTFRTTDNSFRTIILPAVHIPTATQRLLSTSSLCQKYPNETLTQNADGMILSGEVPITRAVQASIDNSNNLPTSWSFRHVTKPINDNTTSDDATVCANNISSDQSSPTPTDCCLKRSSSTRPSHHATMQAAISEVCNHNINLNNGDREWLKWHQRLGHRSFALIRYIMGAGTLAKSQRARALHTQVSKRVECPKCAACCYAKAKRRSPPKLRRSQGHIKDIPSTLRDNTLYPGQEVSVDHLVSSVPGRTYEGFGKGHKSTMFKGSALFVDNATGYTYTHHQRSLNTHDTLRGKEAFEANCRDLGVVVQRYRSDNAAVFHSHEYKLHLESFSQTQKYAGVGQHHANGIVEKSIQDIQSTARTMLVHLAIHWPEQADLALWPMAIDHAVFLHNHLPDQTTGLSPMDKFSRQRWPHSKYHDIHVFGCPTYVLDKKLADGKTIPKFKPRSERHVYLGFSPFHASTVPLVLNPRTGSITPQFNCVFDDWFATIATSIEEIPTFLEEHWQTLFTDSEYQFPADDTDPPALATIPVQPPPPPASPLDTFDSASSPYITGLPDLFEPRSPPSTSNIPSVPTSQSSLERERVPVAPMQATPPLNSTTDSSNQREPELPSQQQREQQAPLPRPTPRNKPNVRSQPPLPRERPIEDLPSTHQFSPNLRRSTRSTKGVSAPILDPDPSQKSYSSKVEYSSHLSELDQSINPDFNDVENLHSFPKDTPFLTAEELVLTPKHESYKRFSTQPDTDDGGIAGFYDLHFSYLGYKLEDKPNFVFMDSRAPADVIEFLKAASSDPDILTWDEAMKHPEEAEQWRKAALKEIRALEHKRTWLEAPESNATVRVIPGTWVFRRKRLPDGTITKFKARWVLRGDLQDLDMDTRADVVAWSSVRIFMVLSLKLGWVMKSIDFTNAFLHAPLPKELPMFAHLPRGFYSNMRSITGERTVLNLQKSCYGTTVAPRLWFEHVMKAFKELGFESSPYDKCFLIRKDMMIVVYVDDCGISCDKPEKIDELVQQLRDKGFDLEIEGDFETFLGVEIEKLDDGRFHLKQTGLIAKVLEAAGLSDCNDNHVPAGPTPLGKDETGEDWPQHPWKYSSIIGMLIYLCTNTRPDISYAVSCAARFNAKPKACHATAVKTILRYLKKTSDKGLIIEFDGTLDLEAYCDADFAGLHKSEDSFDPASAKSRGGYIIFFGGVPLLWKSSLLSCITLSTLEAEYMQLSRTMTVLLGIKNTLEDLLPPLGLQTSNRSITSTVFEDNAGALLLATEQRITPRTRQLLAKWHHFWSWIRKPSDGPPRDANSTWDDGKITAKKISTELQRADMFTKGLTRVLFERNRKMICGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU01</accession>
    <name>A0AAD2CU01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001546">
        <property type="protein sequence ID" value="CAJ1945855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU01"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="134" mass="13943" checksum="650A137FFF11FFE4" modified="2024-05-29" version="1">MSPKCPDRLLPKTQRKNQDQNVDYGKKLNLNQIGATVPANVPAIVPGASASTSGASSVAGSVNTPLRLAGTTGNKMMQVPLGMQLMRTPTQGGSTVTVTYSMNANVEIAFSGMQLSQQGFSGAQVRQGFDATQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUU7</accession>
    <name>A0AAD2CUU7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001191">
        <property type="protein sequence ID" value="CAJ1944056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUU7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1944056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="670" mass="75535" checksum="C6B5C4A98156C856" modified="2024-05-29" version="1">MICLLTTTNNNINTITQLALTLLVVLVAFTPAIIEQLVNRAQIVIAPVRNVINNGIAALLTNTTVATVAAIIDAVQTIANRVLEPDSDAAAFKNNKNIKNIKILALPLSETYLQLILRARPRHWVFRSPQEIIFWTPRHLIPTSTIRATIITALSTIDALEKVANRALESYSNNNHKNIKILALPISETFLQLIPRAPRHLILRASREIIVWTPRYLIRTSFCATVIAAFLRTIIDAIQTINKRGLESDISAVLNKKKSEFLALPISETFLQLVPRAPRHMVLRASREIIVWTPRNLIRTSDPSMVLPRIIELAQEFVNTSTIGTVMSCALASLPTPVPQCWTQRFSLGAVMQLSPPTSFTTFFGGKEPEYYVSSLVSIIVDHHHHHHHQEDKQEEATATPIATTESTDSSIIVLSSSDMLANIAIAADKEKNNLDDDEDEVEHVDAAAAAVLSALSSFAEEDKVESSPSLFYKKEESESFADLKGKRKVVPFWMSKHSIARAAGKKVKGRRGQFKQYLRAQKKADRIKMEQQRRDAVKQQERMDGGHEDMEIDHEEDEVKMEIDYEESTTDACCSFTASNFTRRRGQFKERVVAQNKAGRRKIEQQRRDAKKQELLRQKRGMNEMKIEYENDVFDSSHLASFSEWYRAEFGCEPTSSLDIFDDPSFGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUZ7</accession>
    <name>A0AAD2CUZ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUZ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="163" mass="19290" checksum="8BA0C5801B01EC1D" modified="2024-05-29" version="1">MELSNGDYLDMLRQWKSIDKAVRGTYDPSLPRHAKIRKLMDKAMLVVKLLYKVAKALKSQRKWNKKYAASLYFHWRHLFPDDAFRLQMTPSNKPCFLMLKLVQQARSGDPTNYHQETPPLPFQKPRTKVDNGIIKLDKHRAIKKEWEEVYNMAVARAVPKSWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CW36</accession>
    <name>A0AAD2CW36_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000763">
        <property type="protein sequence ID" value="CAJ1938751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CW36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="195" mass="22360" checksum="45BEE034649B426A" modified="2024-05-29" version="1">MSGLNLSQVPKKPREWPSSRSGSSANKNKNRVATRRKHRERELKPLKNKLKSGIGTKEGSRSTKDSKAILEAKHNLCFQQIGNEMKADYEEHDTILIARCMMQIKAKFDTDEGLNFIQQYYINQGLRQFGDDGKDAVDKELRQMLLRDCFTPEFVKDMAASEQKKAQSVMMLLAEKQFEKTIKGRLVFQGDGTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXC4</accession>
    <name>A0AAD2CXC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS10448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="60"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1946307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="322" mass="34933" checksum="DE9E6B23ECCCE443" modified="2024-05-29" version="1">MAQRLREAFKKVAKQVNSAGGGGSGGGGGGGGGGRAAAAAATSVTALAVAGGLGYGAYNSLFTVPGGHRAIIYNRISGMKDTVYGEGLNFNIPWFERPTVFDIRTRPVNLQTLTGSKDLQMVTIAIRVLHKPDPNKLVEMYRNLGRNYDERILPSIMNECAKAIVARYNANELLTKRDMVSKEISHDLRLRAGYFNVLLEDVAITHLSFSPEYARAVERKQVAQQDAERAKYVVIGAIQEKQTIITKAKGEAESASLIGHAVKKNPGFMKLRRIDAARDIADIVAKSGNKVYLNADSLLLNLLGDSDDKFEKSLSEKGRFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CY89</accession>
    <name>A0AAD2CY89_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001035">
        <property type="protein sequence ID" value="CAJ1941549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CY89"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="483" mass="54694" checksum="B4FB03063A556703" modified="2024-05-29" version="1">MKISYSFVSKHTTEYRHAIRHGRPLFELMEENGDLARNEGSIVRRMLLYGLGNHWIVGKESLKACLSILGTRVQMGQTSFPVASDMVGYGYANLTHATSTDAIICYMPDPVCGRLAMQLMDPEWALGDIKGRPSSWWLRKMKEIFSQGLCRPEKGDFGEIMVALYFLVCADVLRRRDNHNHTTFSVSLEDWIEQLTTGGLERRQGHRSNVDILPKRKSKRLLAAKSQGSRQKMTAEKVDETMAEAYEVEVEASISFIQVCQNYLRACEADWEGFCLQDFLSYMYASGTAFYVFPGCPIVDLVIPIKLSGQRKHYFAPMVISIKSHAFYSPADARWECQRMAERFKRIKESNDKEVFEFFPGALCLLVVFGSTAVSDDNDLTLGHSAVRELAKKKVFSRVLRIPAKDAFAGFCDTFCTLTSKIMFGTSEVFASHSFVRAYCMDDNTEELNTRSALRYSPGKEESELLQNLHEQFKSGYSTSGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYK8</accession>
    <name>A0AAD2CYK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041945696" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="49"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="298"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="623" mass="71360" checksum="45D08D723D1178ED" modified="2024-05-29" version="1">MATLRRFSVGVATLLLTQFSHSQDNANENDILVVDSQNSTAQTPESDQCRIWVGMSTIPGAGLGMFAGKDFDKGELLLPVGDLVIPIVDLGTRRKITFLWNDYTWASHSGYYGATKMAAHETDMASPGFGAVANGYMDFLNVDQDGGCEYGPEELDRLRDPEAGAFSLHHSRMSHAGRKVAKGEELFNNYGNKWFKQRQYKLGVIPLWKDHKRAESLYKKFSEKLLSKYEDSSLSSVVQDLWATFVTDEKNTWQSTVFAALPPKEDYQQMEKLGLKQLKRSQMTRSQDWLDKHALCADNFEFGVSTIPKAGHGLFASRYLSEGSAILPVPLIHIPERSVLTMRQPRKLIDMGHKHEKFTRQQLLLNYCLGHVDSTLVLSPYGPSFGLINHNQTRANVRLQWAKPERSNHFPEALEKDVKWFTTEKGSRLGMEVITLRDIEPGEEILLDYGDDWEKAWREHKAKWRPLEKSLNYVSAYEMNRRQNSTLKTVFEEIKEPYPSNIVLGFREEYNHTGPWRNANETGTDNFFFKEGLSDMTSCEILRREEMNGQTLYAAVLADRNNTDKNVLLEHLLREAFEFSDAPYTTDVFLRNAFRHEIRIPDDMFPEAWKNLREASDFPPPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZL9</accession>
    <name>A0AAD2CZL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 15">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS8784</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 15"/>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="1656"/>
            <end position="1703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1944229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1712" mass="190454" checksum="42CB8725E7546164" modified="2024-05-29" version="1">MGREKRKTRLNKGESGEFLGFAAFAAPAAAPSATKGASPSAPSLTISPIYTGSDSYLSLIFPRIGQKRDATTKAKAVGDLKAFFADDCKPKKAKVEALSHFCYLFHSKLHYDNTPRVRASCLECFLPAAESVPKAWKTLTEIQPEILGIILCSMADPGTEVRMAANALVESLEASDPNNFTEGTWDYVERILSYGSSKAMSEELFQKGKDSASADQKEELEERYERIVGTAIGGMQLYLQKYHSDTAPTTRANVKFLWKAMSSNKPSLRQRTFSLLSTSFQKAPSLVDNDKISKMLLQTLSAEKEASNIPSLLETLISFVASYPQEERSSTMSLYTKPLTKLFKKGCLGASRWSPTVLPIVALLPQEEQASLLTCVWEGRVNVAGLAEELEVVGAVAETATFLLLKASHVFSEIIAKCWLYSLQTFLTTEGSGPARRSLDKLCEILARDWMQLNQASQSKETSAIFQLKDWFWNQELEKVVLEDNVNNGQMLSLIQLLAVKEASEANQWAHIIQKKFHKVLATCQGNSGLVPAMDVYELWIAILEKLSVDHVFDKPKLDKFVMNDLLRWMVIHTSSVSEQADANLTRCDFTLYRLCRSMTNDGVWNTLLKELVAAKCDLSYLQVGLETVLQAQGSADLFPCLTLDELCVQVAQEAVHPLELALDFSVASDLSAEHNQKVSNFLKVCLGLGKYDNLLERTSIESMVKYACPEDYLISMEDNPVLETLVQMIIAGRLGAQDEKSILVQSWRQGGDLWESEAIPFVADKESHLVSLIELASTETKAMLNQVSSEHLSHVWSERANRLLGLCRIESEATLPAPDLSLVGLSDQSKWSSEPSPFLSMSLMNLLSQMESKENKRLLFSNFQGSVLEPFLDILLSLSSANSDILKADFARRRTDTCSALLQAIDTASIENSQLDEWCDKLISLLASLFDKGDELRCCRGVAVLSQLVEFRFRTIRPVESTTDDQLQIHQIVKGDTVWYIVQSEDPSIREKCTIVKVHNDLPGERYFTIRLNRDGEDQERQTVVDRLRKAPFAAGEASAAAVYAKDISKEESMERGKLLKLILDQLIVPNWEKWPTECFELVSIAISQCGLLGGRGIGTDHHMILQKLMKIQSDNLVTLEGLSSDNVDKVASAMQSLSYSLGYGKNVPKLQSLNLVGFSPVSSMKSIVGYLDENEAEVEEEFDSAAAMWLSVSAPEVSDKDLRQQVFWHLYRLSARLIQSEGSDEFSSRDFVALRAIAIAQKENHKSRAGVSLLDDSEAEALSALIKSFFCQWDSESQNGLPLWSSSKIFDNVFSDGLRNRSSLMGHACRPCVDDVVHSLSKESKRVYAAKLLKAFADKGVPLHAEPTAPNSTTASKLDQWCSDLIDEEIEELEDDIDAVAQWVPAKMMNEVESWYEQTEGGNVATPADGDSAVYVVDDATACARMLTWNSLCEITKVAAEKNSVNRSSFAAYITKCKAVDSILNLALSYGNVGTDRKMKFEKVKDANTILESGTEINLAQLSALTIFNTIEVFPSVSKTWWEMGCPKFATQAIREFVETNVSPEILRNELQHMKQTSSFGNMNVKGSAISREVTASYVQDDFTLSVAIATPISFPFRSAVVDCSKTYGVPEKRWKRWALQITQILNTQGGTLGDALMLWKDNVDKEFEGVEPCPVCYSVLHVKTHKQPTVECNTCHNRFHIECLSQWFRQSGKRNCVICQQPWSGTRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D1G5</accession>
    <name>A0AAD2D1G5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001699">
        <property type="protein sequence ID" value="CAJ1946486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D1G5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="51"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="208" mass="24345" checksum="56C10A4E90ACCD49" modified="2024-05-29" version="1">MFSDSLQKPTHRNPPNKRTKQTFVRLSDRTCQTASIKEFPMNGLQESNFNTRYYSHKYNKAGLDYELGISLVDNRLLWIRGPFPAGTNELTVLREQGLLAELKRRKQSAIGDKGYNGEPNHVSTYNSHDNAGVKLFKSRALKRHENFNNLLKQNNILDTRFRHNETRFRDAFEACCVLAQYRIQGEIPLYEILIEDVVDRYNEDRQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FAT3</accession>
    <name>A0AAD2FAT3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1902810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FAT3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042023">
        <property type="term" value="P:DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033246">
        <property type="entry name" value="BIN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34810">
        <property type="entry name" value="DNA-BINDING PROTEIN BIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34810:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN BIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1902810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="229" mass="24424" checksum="D57DFAC6E771601D" modified="2024-05-29" version="1">MPKVNRKKASDVVDSLGSPDKSEEDKGNNKASPTVSDAKAKSKKMAPEDPKSIDPPENDSFDVVLPSLLGTANAGECTLMVEVSPEDARLLDYEGMSGAIGRFEANHHGVIVDLKGNRYHGSILPGPTAMVVNLVKGGQLKVEGITDEYATLAKSKDVMKSLDAVVKGEFDDGFRVRDDNVNKTARQAAAAKVADKKAEDNKSSVTPKTKRRASVTPAKKSSGKKKKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDB4</accession>
    <name>A0AAD2FDB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000091">
        <property type="protein sequence ID" value="CAJ1929618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="112" mass="12687" checksum="1867B34BA7468282" modified="2024-05-29" version="1">MEGIGRVFKFKKGKNEPPESYLGARLRKKSLDGVDMWTMSSYDYVVAAVKNVNKMLQGNTEWKLPKNVPTPMTSARWNMAAGVVDVSWIPEMLNLADCLTKQLTLEKRGCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDV9</accession>
    <name>A0AAD2FDV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcription elongation factor S-II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS3753</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDV9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="10">
        <location>
            <begin position="132"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="8">
        <location>
            <begin position="272"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1934413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34270" checksum="2013400356F9D78F" modified="2024-05-29" version="1">MSTASKVVGIKKSLSKHVPPDGLGDEDIEHCQDCFKKLDDCDMTLNVLTSTLIGTVVSKFKKHEKLGPTAKALVKKWKKVAAGDNSSGPSTSAVAAKKKVAAKQAAVKRRNSGEDVPIPDRAKEEWDGLAEHRRTICSKLYSFLTHGKSSLIKDGINEEAAGSLQIDRSTEVEAAIQKLHANDKGEYASKARSLCFNIKKNVPLACQILLGQIPAENLVKMNSDDLASEEQRAEMAKRAKKSTDSKRLDWDRANEDKINEMCGITGDLLKASLFTCGRCKSVKTTSTQKQTRSADEPMTVFVLCLNCGNRWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDZ2</accession>
    <name>A0AAD2FDZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid:diacylglycerol acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000336">
        <property type="protein sequence ID" value="CAJ1934563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041897388" description="Phospholipid:diacylglycerol acyltransferase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1122" mass="124584" checksum="95898163E1ABDBFA" modified="2024-05-29" version="1">MATQSRSRIRLWILGALIFLGCQQDFHVSVVVRAIEQSSSSHQEGVNNEDHDQTSTSSSSSSAATEENPSSSSFINQGSTTTAFGVARDDDRLTTTTTTTTTTAAAAGKKNKPKANIIAGKAIVVDLTTTSTITNNPTDAIPSSSSQPVDVQSIQEPIVQQNEESEDFNDDNRHHQSEEDDTSSNTDIEKGTKKTLADDGSEKEQFDEHSEPIVSSSTKSLEAAEDTVDAKLPILPQDKVKESRLRPEDVEHIDQIEDSFFDPFTSDPSCETENEAECYAPPDSTIETETIIDATCLQGGGDHLESDSTDSEDMENNKACSADGNKRKVDKHWGNDEQILSMRNQLQSLSNSTTKENKRPPIFLIPGLASTRLVAWKFKKCTGAFASDIKVQDNVWLNLNLVLQMGTVDVNCLRECLQLGLNQSDTDDWETGCKLRPDEGLDAIASLAPGGIGSDLLIGGTNTVYAWLIQWLADNLGYDVSNIVGLPYDWRLTPDKMEERDGFLTMMRKRIEGSVATNGHPGIMIAHSMGNVVFRYFLEWLRIEMRKEAYNDYIKRAKRRAKSKKMQEALYKAKSASSGSTPSAPSATGNSWTEGWMTGVASSIDDIYGWLTSEEATRQQQQQQQKQQQQKYPKWSKTGSESSDNDLEMDSATKAQLWELAVDEGDANWLEWIEAHIWTYVGLSALHLGAINPLRAVISGEHMGLPITDEMAREMELSFGSTNTMNAVSTSTGFCDDPASRTRESEAHGGPNSQRLACLDDIAIDIEATSKDDNDPWKHFPALKSFLRDRVDWNSGKPMIDIEIERCQGKKGKRQCVQENLMHVKPKEVETGEVFRIFNNLWPEEGDPLIIKKDQLDNSFGAAGKPNVLNHTWDRPLIKHVIMAYGVDVTTESGYVYNKQYEVNADGEVAIPKNTTGPPPDLKSVFWEHPRGKVTREHLDGSRGSTLESLLGQKKMKEDQFNMTTGRLARCGDGAVPYLSLSWAHTWLLHAERAKRASSISSKEPTNPLDSIKISHRPQGEIDWIEGPPPEKLTIVNDKLVDVADKKSGHPHGTRYKPEMIRYHNVGVSRKTGIEYTTTVIEAIGVEHKEATRNYDLLAAVFTEALQHMHDDLNLIQDDNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE00</accession>
    <name>A0AAD2FE00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7640 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS2500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000169">
        <property type="protein sequence ID" value="CAJ1931684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019524">
        <property type="entry name" value="B-solenoid_diatom-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056057">
        <property type="entry name" value="DUF7640"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22534">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22534:SF5">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24646">
        <property type="entry name" value="DUF7640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7640" evidence="3">
        <location>
            <begin position="836"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1931684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1227" mass="124979" checksum="3130DCDD7925EC41" modified="2024-05-29" version="1">MSEEERTSRRDRKSGTSSRRGKDRDRGKDRDRDRDRDRDRDKDRDKDRDRDKDHDRRKDKLSSTDRKSSRRHHSDKSSSKDHRSSSRRHASSKGRSPSRSSTKPVPVPSSPLRTSKRSSEAASPSRSKHAKGTDSDAEAHTKEEKLLFVGDDDDDAKAKAKASGGERATTPGIQVVEENKPSSSASKPSKSKSKRSSRPSRGGAAAVGAAAGVGGATALMMNDDKNKHSKKDLMDMDSLAVPNDAMETAGPDEKTNKRKSKQEKKEEEEEEEKKKKRKRAILLCLCLLLLILAIVLGVIFGLRGGEDEVASLQDTPANGSAFPSGSPSGAPSEGPTATFQLYDPPSLEDCELVALNRTSPEERAELDQFNFGLTIDVTLETEEDINATQVVTLASAIQQKLVPLLIGCSDISRRNLVETDTFMIRGASQNQRLLAFGENLREKRYVIRDAFVQGTPQDADCTETRFTAQCHRVFFELSVFLKGPIPLFQIITLISEAEKELIAEGEENNLKVPLELEFPFFAVRLVEGISNLSPTTAPSSMPTGIPSIPPSDVPSETPTGGSGSGGPGGGPGGGPGGGPGGGPGGPGAPTAPTLAPVIGEGEGSMQPSSVPSESPSEFPTSAPVSGPTLPPTPRPTALPSFSPSLVPTIPPSSAPTLAPVIGPTPPPSSQPSVVPSVGPSLVPTPVASNAPSMNPSSKPSRAPSSLPSMRPSMRPSSNPSTKPSTKPSVAPSMKPSMVPSEAPSGSPSAKLCYCLLSDSCDSPISRVTIGCGSCAASQSCVNLSGTGTIGENSCLEANACDGTTLGTIGDGSCTLANACNGADVGTIAGGSCTGLDACNGATGTRILGGSCLVTNSCKGAQVDTIAAGSCTGLNACTDADGTGIGAGSCLAENSCNAAQVDTIAAGSCTRLNACTNADGTGIGAGSCLAENSCNGATTDIGTGSCTAARSCALREITAGDGSCVGANSCRNDANGSLGALDVGAGSCASAYGCFSQSGTAGDRSCLGDYACAGRSILTIGEGSCIEANSCSGEEYASGTVPSTFAKPITVGAGTCTVSGSCRGRELDAGAASCTAAYSCDGFGNQGGTIKLDPSKTGALTVGDGSCTGSNGCLSYSGKVEATSCIGENACAGRNVLTIGEDSCKGVGACSGLVRDQGNDIVPTDPAAIRSMTVGSGSCNCDGCCACMTIVPANSCNAVGNNAVAASNGACCKANGDPIFTAIPGILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FES4</accession>
    <name>A0AAD2FES4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000273">
        <property type="protein sequence ID" value="CAJ1933465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FES4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="221" mass="26059" checksum="677D34F4852CC082" modified="2024-05-29" version="1" fragment="single">AGGYLDFQQYFKSDHRGLWIDIDLEATLGAPPVNSPSFHPRRLTLADGRSVDRYIKAAEAGYRHFRLPQLLTQLADDILVQDGYLTANQQDRFNTIHRQACEIRRRAERNCRKLSMGKVHWSPQMQQKWDRLHLYQLLILGHKKVRTSSRKVRRLLKKTGLSDAWKLLEADLQATWYLEHQEYKEVKRKRAHQWRLKYLESQSAAVQKAKKGNIKARSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEU3</accession>
    <name>A0AAD2FEU3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000287">
        <property type="protein sequence ID" value="CAJ1933613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEU3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="300" mass="32181" checksum="C4BC930C8B424591" modified="2024-05-29" version="1">MSTLSNGLCSPVDPSSGMSTLSNGLCSPADPSSKAQSKSKKRLASIPENPKGAKEHNLRPSPSVPMQFKLTPPKGRSNPYQCTAPLDATPPWKQVITSDAVHVITSTPTGTQEASVPADAVVASTLRGRTNEENGAEEHNSALTYRDTVASPPAPTVPLTTDVPSCCPLDCLSLSAHYIFNVSVVFDWQSIGLSNFNQVQTAYNTFHQFASSIWGKITSKVVLCFADRLWIVIHFPAIVCLQIQHQRSCSHLIAVAHKSCCKSGFKDIILELVLSCSIGASNSSIRFCLDCKILEPGNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG33</accession>
    <name>A0AAD2FG33_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000502">
        <property type="protein sequence ID" value="CAJ1935741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34123">
        <property type="entry name" value="OS04G0578200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34123:SF1">
        <property type="entry name" value="OS04G0578200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10184">
        <property type="entry name" value="DUF2358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042223284" evidence="1">
        <location>
            <begin position="21"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="239" mass="27405" checksum="0D4FC9051F478C58" modified="2024-05-29" version="1">MRSQQVLLLCLHLTASGVNSFTSQESVAIKNRTPLYGKTNDQEVSSYSDTDAASKGFVSALTNVFNAAAGPSEDNSIRKQKASPKNVEELQSRIRDDYEINNYLWTGKLDLDCFTDSCRFTDPTLTFQGTDKFKQNTDSLIPLVERFVENYQSILLDIRRTDEYIETRWNMVGELNGLFWKPEINVIGRTKFWFNPKDYLVYFYDESWEVPAFQALLQLVTPAKTFPNSSAPKEETKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH29</accession>
    <name>A0AAD2FH29_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Immune mapped protein 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000125">
        <property type="protein sequence ID" value="CAJ1931089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040955">
        <property type="entry name" value="IMP2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18590">
        <property type="entry name" value="IMP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immune mapped protein 2 N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1931089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="213" mass="22608" checksum="B9B335E47B9EB3FE" modified="2024-05-29" version="1">MGCNASKQEGNVSRSAPGGGSKAKGGKAKAGKSKSKGFASATSAPVPDGGACYLVYEPDSSGRLVEHYSKTAIEGAIGRWTPGKDKKIAGFKFTQNHGKVILIGNCSGGVAGRKAYCAGWNQFVKSAKLNKGEIMFWEPLEGVKGLPVDVWLYTDDNRPGFQSMKLETGVAVTLDKMQGVATLPKDSDFYEGVQIDLFKWLDDGNSKGASIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHU3</accession>
    <name>A0AAD2FHU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS3053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF2">
        <property type="entry name" value="INACTIVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1251"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1335"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1383"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1453"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1531"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1561"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="541"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="676"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1658"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1932869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1697" mass="188651" checksum="F8CF75F00D43A58D" modified="2024-05-29" version="1">MVMTIDDMDIPRKPSTMTPMRARSPSRPPPPEIKDDDSSTLSGEGDDSKMPMTIDEMDIPRKPSAASPSRPRQPLVPLADSDDSSTLPAAEGEDTYEPAGRGESKMIMTIDDMAIPRKPSSSPPRQPLVPLADSDDSSTLPAAEGEDTYEPAGRGDSKMIMTIDDRAIPRKPSSSPPRKQLVPLADSDDSSTLPAAEGEDTYEPAGRGDSKMTMTIDDMAIPRKPSSNTPMRPLAPPRALPLPQLSDDDSSTLPEEEPKRVMTIDDMTIPRKPSSMPSMSPTRARSRSPARPRTPPQMKDDDSSTLPGEGEDTFEIPNNEGEYKIAQKIQPQNKKAGRGLVSFSLSGGPLFSPKSRKYMEKIHDPTNDDDVSSLEESNRSLGFDMSDDFPIPAVRGNTTGLAAQAVPLRRSQLEDEENGALGEVGDTFDMEDVKPAKKRGFNLRGNRRVSRMGIGNKSPKKSPKNSRSPKNSPKKSPSKVDSANGDFVARMTSAELKARRKELEYGDDSSTMGGLGDTLELVETEPKKKRVFNLRGNKRVSLLGGFGKSNNGSSDDDDDEEETDEFNLAPLTAEAMSRRRKELEYGDDSSTVGGEGDTLEPVEAKPKRGMSKMVSFSMSSGPASLIGKLSPKRNKKTLGGLKEGVSDDESDDLLGGLSSKSRTISHSGVNMAGGIGVGKVPNSPMVPPSPIQVSRRRKPRRRVKRGGMVTTPSSMNLGEVMSNPFTTEDMEEVNRAQSRRGSVSSVVSASELSQETDLHKALADEDATMEQLNYLLQNEPAAASIHDHDGKLPLHIVAENEQLHLNLGQALDDFILEDLIHRNRRALITTNYAGEFPFVGGIREWVDNINEVAENNIPDLSTFESKKAESPKPMGGRRRMSLLGAFGAGPKEPDSDDSSELALVAPNNDVEDPAKKEEILRDLAEHLIPWNVFIDDLALWSIDMLSMLIEREPLKAMWTIKIVDTVASIPCFLKTVLLIDDDEQRKHVLQSRLLHEVMLHEKSMGPWLVYLITSDDEVAQDRAVMYLQLMTVIEGKMAAAHRSTFSTRLSGAFKSADNQFFERKNKVYTKAAELPGIIPSFMQFNSSNFSKCSTSSIVQFILDKKLFEPKSLTVILFDVFFLTMAVVLFTLCSNEVFKLISNMRYSPMLTFAVNQTAYNLCEDGTLGRDDHTCLYYNEKQANGDPFNIGSVSLFRPTFDCDLECQICKGLGNFEGDATKGGSIIEYSGEEALSEEFLFTCYAIGDRYPIDTFLIFCVMALSFNCLYFMSRSLAAWGRVPRKYLAAQFFFVFTVVDTVSIIFPVVLVIIFLLFIYQTDKYTGIGDGNYVPLKIYEVWMYEAEWLSAASAGCVGFLYLKILMYFKVLNQYTATFIFALGEVVKDIFWFFWIMVVIIFAFSQMFYTTLSCKEGFCKADFGQSESPYNFFSDSLLITYSILLGEFDLEQYNSPFTTILFVLYTFGIVIVVLNFLIAIVGDSFDKSMIKIESHFGRARLMFMVELSAFQSYAKVPFRVKKQNYRRFLLGGNWKGCISYIILSAGLVSGFVLLIINKDLVTKSSTPVIAMIGVTLGLMILSPFIWKLGLVRFLVHSSLLSPVRRGVGKLLIMFFRVILGKSILSERSEKDQKDWGGRLKHIVGAIDEKIRESEALTLSTIAENDERQNRIIEKMELRMENLEEDVSDMKKMLIKIQKMLEEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIS1</accession>
    <name>A0AAD2FIS1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000369">
        <property type="protein sequence ID" value="CAJ1934726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIS1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="222" mass="25502" checksum="965990B28FAD2886" modified="2024-05-29" version="1">MSLQHIINLNNYMVFLLESKQSSWAVKNGVHAMELMDQLNEDQHLTLASQSSLSVPCKQEDAHDIDHYMHYMEHSDLYDWDEPSDDYVYERGVTLPSTVTDFKCIIAVLIFNLALSHQLSASTRHQHDDLRQKLLHKAKRLYELALREQIVDHSTAFKFAAVNNVAVIYRMMGDDETSQKYLDYLVSLRMHVVSVGDCPQLQQMNGFWRNVFGKGISIAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIT3</accession>
    <name>A0AAD2FIT3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIT3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="251" mass="27556" checksum="FAD85B931C8B1D8F" modified="2024-05-29" version="1">MESACSYNGMDTSIRKLSIDDTSGGIISPSCAGESSKGTEPKQWHIMTNLSTSLVQALDADTSAHPVTPCPSDSSCCTDCGVSSSMSHAAAGSPLSWDHQSPVNNKIPTEVQMAQQQQQQQQSKENAQKPSVPAVVNQQQQQQSAASNAAVSKNVTSEAQKRRHFLILVQIIFKVLKQAKAQDAITFHCKKVIRECTQRNRQGDPNFTSLVDSATPRLRKVVGEKTWRRSILLLKHYIQQQQQQQQPAMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJC9</accession>
    <name>A0AAD2FJC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001313">
        <property type="protein sequence ID" value="CAJ1945026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJC9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="608" mass="67810" checksum="59AE4AC91F9EC58F" modified="2024-05-29" version="1">MPNKRGNDDKALTCDAITRTNRPIDFVNNLANNHCVVEQVEETNKGAGHSHHIGQHQGDANANNLNQTDTADTPISHQSRSSSMQDDETLPDILMEFGSLVASEIENTGNFNENSHSADKKMTHNNAIITSNSDTPDDSKNVHRISFSASASGSTEVVDAKYAEEQFSDFTLDSFLDVSADSEQSALQPFDEFEFSVSSEEDDDMDSISGDQGNDNEPKPNANTDNNNAINPTKSIGALDSHEDSVSTESTTSLSSEEESTNNAAAESGNKTNCVSSSTTATTTGANDSNTIHRNQQRTDPLAIAPRPSDTPISFRSKEFQQYLSSFHSNESRRIRSACKGIDSCEHPPIGTLEDRFESVLDRPFRYWKALDQVLEYSNPEWLNYQRGRMVHYLIHFLELKIGFQDYNVDPPSRSLSTDDQESNASVSNGGGQLMPSPVVDEAWKALILESQLYEKITRYLQEFHGQPVYQYIHYSRVRTVMNSSTKRQATIPEELITTQSLFQDYFHELMPSSIRQVRTILPSRRSVPASRFSRAQTRTTNAQLAPFQCTPLTAAHKRHGQMQAQKRLNQNYNDMTTSPSSGGLRGLQVLNVNDEMMPTKIKHVVWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKU8</accession>
    <name>A0AAD2FKU8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000735">
        <property type="protein sequence ID" value="CAJ1938566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKU8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="116" mass="13098" checksum="C8011F400990CB56" modified="2024-05-29" version="1">MKKSADPVHDFLDFWEAIQKVFAMKQGTNKNLMHFKEQFLRQAEVLQDLYGVACNRIPMQLQSNKNNSSDAGSSDKLLHGSGLLSKYNPQSTRYIEDSHGCAQKSGSDPLPRKRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMB1</accession>
    <name>A0AAD2FMB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001347">
        <property type="protein sequence ID" value="CAJ1945309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="236" mass="26858" checksum="7BAC7ADADF5F0831" modified="2024-05-29" version="1">MGKNSGQKRKQMRTDPPLNFMTVGSFATMEQAQKLDFSVNEVLAVMHFPIGLNLRNTANLKGIYDTGGCCNIGEKAYHLIIAKQYPQLVKQVYDFPKIHYDPIKIGGIKDSVNIEAIIEYYIPFANEDGENHTLMIGLTEQLPIDTLFGLPFMLKAKMAPDFHRKTVTSSLFNQEFELTMERPKMLPVQHIRRDQAASPKVLFNNNKKETGQRVIIIRKHQHSAPTTTTNITPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMN1</accession>
    <name>A0AAD2FMN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="229"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="56806" checksum="27923E21D980499E" modified="2024-05-29" version="1">MPNRSIDIASSEEFSYNVEAYRAEILSEGYVDERSTGFDLGNRGGGRYEGPTAAGREGAPKSARQPQASPGPNAVNVFRRFLGGAPGATVPTTSQKRVAIATSKQSSLFDDSTATDAFSEASAETEVMGSTGRSTASSGSGMESTFDYSTVGGSTAGTSRYDTSRYSSQYETNQTPPIPEGSIARHNIPTSNLKNTVKMATMSLTEAALEENRKNYGWRIDPAQSFSDWEIKIVAESGQVKQYNVHRMALAAGPRKSEYFADLFGKQVNNFKNQRLRLEMPDESAKVFPVFLDFVYGENDLESVQEKEEAYAVYEQAEFFDTPLLKQSVANWCKKRLQWYNIPDFLPELERFEDAGPLVRMAVDLCAAEFEELGTDFGSKIEPKYLQMIFENLIEREFKFDRGADYISEMILECCTAHPDMAEANFLGLTDMRFLPLAPVEAVLRLLAEEGKFCDPNLEASTLQSRCIKSLSENWEYFSFQFPSKDDMAAAMMALPKSIMAQLLVLTTELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNA6</accession>
    <name>A0AAD2FNA6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alanine racemase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS10925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001721">
        <property type="protein sequence ID" value="CAJ1946979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30511">
        <property type="entry name" value="ALANINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30511:SF0">
        <property type="entry name" value="ALANINE RACEMASE, CATABOLIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase C-terminal" evidence="5">
        <location>
            <begin position="531"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1946979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="672" mass="73127" checksum="6B852C8A626D46CE" modified="2024-05-29" version="1">MRNKMRSGNANVRNSSRPSVGSHGELDGGDIPNVPSSELRAVHKIHLARLHHNYIEVEAAANRQRCSVIVVVKADGYGHGAIRTALFLADNMGADAFAVATLEEGIALRKAFQDTPPGMPYNPSGGNSLQAKNSNSTKDVASLFQPSTNTTNPTRSIDPSFSRRRYHRPAKVRILVLGPPAPAKNVFDDFLHFNIEVMISGPEVAKALLEWVCNTEERKRLQVERAATEAKERALQLQSNVQQTQQGTNHSSRLRKKTSDPDSPNNENSVNFNMETSQLYRPPSATLGNVTGMDLAKEVRQILNNQKMTSASTTNSSDTTILTNSSLNASPKGKTAIKTFPGIEEAAKNSRSRHKAISKATRCEPDTTDAHPKNPLSKSSLGIGRKRLRWHALVDSGMGRLGFRTDTVSSEEEGQRRDTVDIMKELLELEDNMDVPVEFFGMCTHMADASSSSYTGSQMERFKFLLKRARAAGISVPTISTDNSAALLTTEHKHFDPKELLTQDFTDSRGFVRTGGAIYGQRPAFHQIRAISTLCASVRHVAILKQGESVGYDRAYIAPSDVRIATIAIGFADGYPRELGNGVGKVAIRGSLFPVAGNVCMDMLMVDLGPAQSSDSPGASIVVGDTAILWGPESDEDGDGLVRLQDLAAQLNTTQSALTCGLNKDRVLRQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNK6</accession>
    <name>A0AAD2FNK6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001726">
        <property type="protein sequence ID" value="CAJ1947440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="539" mass="60427" checksum="F0F05E5A9CD7A6C4" modified="2024-05-29" version="1">MNLDNSQLTKYLIAAFDPETMEVNPSEEIWSLRILAMQISLQNPFSFFCIDEFEGKPDDNYFFSGEMSNPRLHLEHPLVGFWLICSELFDYPWINEFLLEYYNDPPSAIVDAIKQTRSGQSLNKAPNRVSVKEPDPPCIQKIYDLMYSIDEPGTDVQGDSTSSKGDQVQNSNRFAPLQSDDYSSDGSGIEEIDEVEVVAVKKNDSKALESSDEEEDTDADDTYDRENIVDDAMEEDDDDKRAGANPHDEAMDNNTLPLTSPKLTATQDSAGTRTLMEPSETTPSRVQRPPTLAERISNLVQVNMEGTPGKCHIFETTFAVDYQGSGSGTVAEALLSTVLNSMEEAINNSPNEFKLLPISDTTYKQPNLWTQNSVDLRNRISTYRALATYCDMEYGNCPYAATNSKPGKKKLRTRIRVGFSAEALVEAVQDYLHTGLHQLGRGAGCYPSPLQYGEIVKIGSCSFIPAEVNFSAYAKELMRLFDFEVLIGIKMDWVSIPYTGRAKYGERSPGVTSPHCFTRRIHAKRVDIKLKNQKTKTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP25</accession>
    <name>A0AAD2FP25_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP25"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="233"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1947831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="476" mass="54412" checksum="FDB754E08C23B191" modified="2024-05-29" version="1">MSPKSESETLLSGSSNSEDEDTQVFEHDDQATYIICKSKKPYVNPTVPAGTKPEDVIKTLNLDLGQNFVNAESKIVLWIIRFLSSVCVEWWEFLFFRFWKLVPLSIRRGLTMYGWKIYFKLHKAILGRRTGVHPSQSPEYHALTSIMWWSRLLPISPARMRFALSQLYVCTPNVVEAYNAEMIEQEMPLHNATNSNDKKSIDDILTIPICQQDHKTVRGLFLHQGKEPTEHLILWLYGGAYLSGDVVGNSSPADWVAKQTKMDVFVPEFRLAPDGDLNDVLWDVALAYRWLLNKTGKDPSQIFFLGVSSGAAICIRLMQFMVQQQNGEKTLPEYIPKLGLPPKGAVLFGPYVDYTKERKGSFLHYPRLDLIVNESVQRDGLPYLEKFIPDGKRKEYSPVYGSMKGLPPLCVVVSEHEAVYDMSMEVVNKARKDGVSVTVGIWKYMCHVFTFLWGFIPEGKQSMEFACKWIREEARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPK2</accession>
    <name>A0AAD2FPK2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001744">
        <property type="protein sequence ID" value="CAJ1948169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPK2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="439" mass="49528" checksum="99D1CFA399FB4058" modified="2024-05-29" version="1">MAPLRIRKALMKANPDYGSVYMYKNDILDGLYRIRLSTTGALKLGVIIPRFEGLPQLVALPLVLPMGWTESPPWFCAFTETVANLTNIDLQQNKQVPPHPLGRAAAITDFEVRDTQVVRPIPKSHQPLIYQRPLKKMEVFVDNFVGMGQDHPSNPFKKKQAVLSHNIDKVFRPNRPTDNQWRKEPQSQLKMAKGDASWHTVKEALGWNWGATTKTLQLKEKRVSKALSLLGKVLDCKRVSLKRWQQVVRLTPEVREQLEIFQDAKRPTTLEELVPGVDFYVGTCDAAKLERGAVWFTDNGEAIVWREPYQEAVKKEVISYHNLTGKLTDSDLELEGTVLHHFVLGKTAQVEGEATYTGCDKTAAVLWSTKGSSTSQKARARTLRLAAGLQREQRAHHHIGHLSGTNIKWPTMLADCGTHILIARIHRSTLGNFTGWQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPX8</accession>
    <name>A0AAD2FPX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS11902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="1144"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="805"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1428"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="715"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1479"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1508"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1564"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1592"/>
            <end position="1603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1949055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2248" mass="253143" checksum="CCC766149EBD6BEB" modified="2024-05-29" version="1">MSSTSGGTPSTGTLPSYITKPTCGGITTVGPNEYEIYTGGKPDDTRSGLDSSAPTERVYPGQTRPISGYRSMKSQTYRTTFEGTTKISKTSQQTKLKRDLHQHFVENGLDSITYLPDANGATTSVILSADSFSQETALAAYKTMLPKYDKYCIANDKDAAKYLLNAVDDDLKDTIELFHTESDGFIAVWFSLLANITDNNIDRKKSLEDEIKSITVSQFPQQNLKSMVAKLKPICDELDAMESYEPDNSIHMLDNFSYAGSGTDPSNPHTMRFRSKIITLRDKLDDAITTCRNMSKATRDTHLKGQGLHYTQLLKTISDIYVKLEHNKTWPPSMTPLDSRTPAALNMAALKDSLSPSVAAQFEAYILQQSKGRQPPDEDKKSTNPKHVPPTPSMTPTETIEGIKHYVQDIKGVKNNWCGRCRRWTPTHWTWMHGRKPDDKPTPVTPASTESHLLINKQDSSGSDDDTSLETNLASSGFKYVFYHMELPRPTPAKISERISSPEILDEAPSSSIMDKSYLWSYLWYTFQVAILGFSLFGALLCTTTTIDALPGLSALSAFFQDIPRLVDTYTFTWHAIAPLLWYLIYSLLFIGPDRFAAPTPVPRHIRRQIQRHLFRESRRKPRGIQKPSFRHPRYQPSRADCIRRFHATTTFFPSSFHTVSEGENGEIPVYRRHIHVSYTRPQARTRPTKFSLRSKWKSPMERKLRQWMLDYSFRSYHKKRIQKLRQRAKQHEKAMKETRKEQANAESIRLQQLRSQRTSELLLQGSLDPILPPFDVWDTDSWDNYTTPPDDYCVESSTCQECSLSDDESTNYSTNSSTSHASTSDETTANPPSIIHLYPVMIGSSVAEYANDHLFLTDHCAKDLEPAFPVIWDSGASVCVSPHLDDFVGPLGPPPCSSTKGVGGPVEVKGTGNVKWTFRTTDNSFRTIILPAVHIPTATQRLLSTSSLCQKYPNETLTQNADGMILSGEVPITRAVQASIDNSNNLPTSWSFRHVTKPINDNTTSDDATVCANNISSDQSSPTPTDCCLKRSSSTRPSHHATMQAAISEVCNHNINLNNGDREWLKWHQRLGHRSFALIRYIMGAGTLAKSQRARALHTQVSKRVECPKCAACCYAKAKRRSPPKLRRSQGHIKDIPSTLRDNTLYPGQEVSVDHLVSSVPGRTYEGFGKGHKSTMFKGSALFVDNATGYTYTHHQRSLNTHDTLRGKEAFEANCRDLGVVVQRYRSDNAAVFHSHEYKLHLESFSQTQKYAGVGQHHANGIVEKSIQDIQSTARTMLVHLAIHWPEQADLALWPMAIDHAVFLHNHLPDQTTGLSPMDKFSRQRWPHSKYHDIHVFGCPTYVLDKKLADGKTIPKFKPRSERHVYLGFSPFHASTVPLVLNPRTGSITPQFNCVFDDWFATIATSIEEIPTFLEEHWQTLFTDSEYQFPADDTDPPALATIPVQPPPPPASPLDTFDSASSPYITGLPDLFEPRSPPSTSNIPSVPTSQSSLERERVPVAPMQATPPLNSTTDSSNQREPELPSQQQREQQAPLPRPTPRNKPNVRSQPPLPRERPIEDLPSTHQFSPNLRRSTRSTKGVSAPILDPDPSQKSYSSKVEYSSHLSELDQSINPDFNDVENLHSFPKDTPFLTAEELVLTPKHESYKRFSTQPDTDDGGIAGFYDLHFSYLGYKLEDKPNFVFMDSRAPADVIEFLKAASSDPDILTWDEAMKHPEEAEQWRKAALKEIRALEHKRTWLEAPESNATVRVIPGTWVFRRKRLPDGTITKFKARWVLRGDLQDLDMDTRADVVAWSSVRIFMVLSLKLGWVMKSIDFTNAFLHAPLPKELPMFAHLPRGFYSNMRSITGERTVLNLQKSCYGTTVAPRLWFEHVMKAFKELGFESSPYDKCFLIRKDMMIVVYVDDCGISCDKPEKIDELVQQLRDKGFDLEIEGDFETFLGVEIEKLDDGRFHLKQTGLIAKVLEAAGLSDCNDNHVPAGPTPLGKDETGEDWPQHPWKYSSIIGMLIYLCTNTRPDISYAVSCAARFNAKPKACHATAVKTILRYLKKTSDKGLIIEFDGTLDLEAYCDADFAGLHKSEDSFDPASAKSRGGYIIFFGGVPLLWKSSLLSCITLSTLEAEYMQLSRTMTVLLGIKNTLEDLLPPLGLQTSNRSITSTVFEDNAGALLLATEQRITPRTRQLLAKWHHFWSWIRKPSDGPPRDANSTWDDGKITAKKISTELQRADMFTKGLTRVLFERNRKMICGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQT0</accession>
    <name>A0AAD2FQT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase ATP-dependent N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase ATP-dependent N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="285" mass="32657" checksum="E675D53F0B2C1040" modified="2024-05-29" version="1">MFHIKHYKEYLYQDEPLAQNYAVDKHVYGASIVQQDCCIMNNLSFYNTCATMESVWKAQSGKLGLKVECLLPNDLVNIAKQECESLYPLLRLYCPEKDNDRKYNVDENVIAQAYCDALGLEELGGIVNLKEWRDLAKMLHNFTDAEICSSDVVGDLSLVVEHVMDERTNYTQSKLRLGDINGLLDEFAALNPKERHHQYKSRGNKENITPNAKPNLAEWFRKVIYQEKLSPMEHKWLVRIIIKKPDFGIQSTSILRAVSPYANGLLAADGNLKRMCDKLAGPYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU26</accession>
    <name>A0AAD2FU26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001821">
        <property type="protein sequence ID" value="CAJ1953163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="110" mass="12696" checksum="A0BE4ADB16342737" modified="2024-05-29" version="1">MGGAAWSPTGQSIRDRITLWRLLLKGRRQCRVSSRKIRRLLLKTNEPLAWKLTTAELESHLTQDLGQYREAKRGLTSKWRKAHVTARTRALLKSATRRQANKNDITAYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV13</accession>
    <name>A0AAD2FV13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS14609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1954011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041922334" description="VWFD domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="248"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="566"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="850"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="877"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="918"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="970"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1004"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1954011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1304" mass="141414" checksum="3FEE118EE7C2F0CF" modified="2024-05-29" version="1">MVKLHLSLAAAFAAFTLTTAEKAPGDIIEMKMATTGQTDQIRILTKPRPGYTPAADAPSVWNMKDGCEDVSSVDFIFSPVDDESKCCKLESLDGFNLWPEQQGYTIPGGANIVAQEQFALDNGCFERNRGSGGSYTLQSGETYNSYMAQFLSHDQSTVFFDNVVEFHNQDIVAIIHDTDKLKESDQLFALGGQSTYKDVRDDEWRGFEANSHRYESLHVNCLARPSPGSCPVTLSTAVSEVAVSNESCEGRGWGDPHMVTFDGLRYDVHVKGELILVKSLDSAFEIQGRTEAVENHNARPAVTTGIVVNEVGDNPRIQVSLARDASDTYTEVLRASGCRGDHCNCPVQLFVDGVARPVSSGSGNTMASVAVTGGNRITIQYPETKVKVTMDVRNWRQTCHFSVTYTLADCRPNENIVGLVGSPDNEWRNDWMQRDGTPIPIPPSLKKGAGFEPTYIYTRDNWCVDKESDSYFEYEANTDFAFFDECDNPYDPSLEQAVANADAAVIEECQGDVFCIVDSIALGPEAAEAYLEDPALNHTLSQTASTDIEIVLQVPDESPDPNCPVCKARGWGDPHIITFDGVTYDVHVKGELTFLKSLSTDFAIQARTQIVANHPKGPAVTTAVVVHEDSTLGLPVVQVSLGKDEDSELATMIGPCAVQLFVDEEAKDIRLGTGSSDVTVQVKNKRIVVEYASTNLRLDMDVKVWRDTCHFSVNYFLADCRCDETLVGILGQPDGDSYNEWHDHTGNAVDIPSNGRKRRGIEAYNYSMTWCISEEDSHFTYESGMNHGTFDKCTSDNFDLDIDDLIENADTDTIDKCTIDGVLEEGCVLECEFLGDEACDEYIVIIQETETVEITDEPTSGPTPVPTSGPTRVPTSGPTPVPTSGPTPVPTPVPTSGPTPVPTSGPTPVPTSGPTPVPTLEGSSGPTVAASSSPTTLPTPGPTSGPTSGPTKEPTPVPTSGPTLVPTSEASSGPTVTASSSPTTLPTPGPTSEPTSGPTPVPTSGPTSVPTSAPTKQSQLGTAASDITTPETNVTNPDEILESDSGSRGDPHFKSWVGEHFEYHGQCDLVLAKDANFADGLGLDVQIRTKLVRFWSYIKRAAIRIGDDILEVEGSGDMSETDPLYWFNFVHQRPVQTVGGFPVQITKGTGRSHRHKFEIDLSSKYPGQKIVIATMKEFVQVDFVNASAKAFGNAVGMLGDFKTGKTYARDQTTVINDFIELGNEWQVLPQDNILFQDVSDPQFPKRCILPEDPRGDRRRRLEESTITMEEAEAACSKGLSDPLDIKDCVYDVLATQDMDMVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWE7</accession>
    <name>A0AAD2FWE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052442">
        <property type="entry name" value="Env_Response_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="1094"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="789"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1954706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1553" mass="173431" checksum="5E9AFAE0D22EAAAD" modified="2024-05-29" version="1">MADSQKEAEMDNKKATEGHSNGGIPPEEDKKDPKADKTTSEGPPDEAGADEAHEETSETSNANKNEAKSSDKDDSNQGETTAEDAKSSEDNNDETDEPVSNDVDSKPSSPETKDIKPSGPKDPHVGKTMEKQMLLPSGYPSTLEGKVVAYQEPSGRLPPRWKVEFAAPGVRIEEEYTLDELNAATDGAEVEAAPGPALSAIEERHRDHLVHSLVNSDLMATLLVYAALEEALQSLLQEQQENPAQSSSSSSKGGRGKKNIHPPLYYTKNPSSYLQAPTATDTTPSQSSNSVQFTPASLAQRVRAGAEWAWSLLEAKKPPPPVIEGPGRPRRSSRQPTKPADDQINHPNPVQRGGRVAMWLLHKLEDESKKGEEREQAGPVKVKSASPTKEAKKEKNEHSTEPEPKEEPTEDDEEKEAQATLEEEESIPESKSKEDDDEDFDDMDVEDEDDEELEGVEVERGRLSPVHGSDDDEEEEEDIEDAILFENPYFEPGFESILEHLARPRVISGEMVQEALCEAILRVKHNKRAAEHGVATSELESIDEFVLDQEAPDFPVGKVVVKCISGESFGDLKNLDAQTFSRCKFVLDVVGDQEKSHQSKRQEELLEQELIFKEQKAWEKWRFRGINEGCSNWSSWIDTISEFAKGKYGQSGAIETEAASSSAMETKDDDETLAKKLEIAEEEPSGRRRTRRAANPGSSEGVFYGNQSQLTQKQLMDALLRLIKANQCQTLLGLQQVVAEDSSDPIRRCRAGLGKLLWKQNRIVRLETSTDLSDSEALKELSKTQLLTIEEEKDDDEDEDETKDEKPYELSDAQKALVAYMKELHVTELRLRQLILRNLAETPLAIIATAADERLTSSDALDGSQFEDESSVEWFTEGHDFIGKLLCRPEAVEGTTDMTECVWFRIRDYSKSVKSEGEEAAENPLLMRRRMRFRAEAAAPPGADYTYEGDMVLLTEAQVKAGLKAAEIEKKRIEAEAADGNPFSGGSGDKVSLVPLEIDEGMDSAEDEEIGGRIIGHDTVLDDDDVEHRILFLPDASRGEQKASFWATLDVRADTSTFICQPSGSTLWYSIEHFDYNPGTDAFRECQNIVKYLQRQSKIGPFLEPVDPVALNIPNYFSVIKNPMDVSTLSEKLENGHYSSVPPGQSSLKSPTARMLNGPFRKDVELIFDNAMTFNPPDDWIHVAASAVKRNVLKKIADISFTADQKSGGGRSRQRRSVYVDDGSDVDMYEYESDEDDEYDGGRKRKRKGKRKMVKDEYHSRAIENAIRLQATLREANDLRGPFANLPINMEVSSFSLQPKWSCRPSQQHKEVVEESNEERSQEIAELLELQKEVAVTEVAGLRRSTRAHAEPTTRRSAAKDLKVGFLSSVEEEHSVSGDVTPLPQTRLDVEMHQEKCHEEFYAPLYRTHASMITTTNEKGVGEYMNGSFPPYLGRVVPIGPDEVSWEIRDQFLVPAIRWVLRGLMRSGHVSAIEPMVVNQSPGIIIANHVYCYDSNLKPFELLDVKELQREKRGNRAADESESEDEVELSEYEQLRAQRVARNAERLKMLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXH1</accession>
    <name>A0AAD2FXH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1955960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16128">
        <property type="entry name" value="FAD/NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16128:SF5">
        <property type="entry name" value="FAD_NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="56479" checksum="38B29AF7C9E4AB32" modified="2024-05-29" version="1">MSMSSTNTNTNRRNNNNNNNQRDTFPKRPNNNNNNNNNNGRQSVAIIGGGISGLSCAQELVLGNNSNNNKYDVTVYDTGRLRPGGRCASRQPGDPMKPPEQENQNNNNNDDDFPLLSQYRYDHAAQFIAAPGKENEAFAKQLEQWKSSGILKEFPQGSVCSIDKNGKVAPIQDQTFYYGTNGMGNVPLAMVDQAKQSSNFALEQDTWVSPSSGVKYQKNSGTWKLQAKGKTLGYYDKLVIAHNGKCADRIMSKTPSKEVHSLLRVNFSPNVPAHGGNKMTLNSLYSVTVVLPLESEWSKTLPPNFVCGMLADHPQVRSLTCQTRKYNDQQQEMEQQHEVWTIISSATFGKKHKAPQEFLPQEVIDKVTALLVQAVDGVLKTSVGGTPETPNNGSDKKGDDAPKETTNKMDTNKAASQVLEHRVQLWGAAVPLNVWKNEEGFLYDSNNNVGVVGDWLVEPSIGGAWTSGYQLAQHLNNNHQSLESTEHKIIVGLEGGSFERSESVKSAGIAAIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYC7</accession>
    <name>A0AAD2FYC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS16585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYC7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042018969" description="Fatty acid hydroxylase domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="219"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1957178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="41802" checksum="DDE066A4853DA090" modified="2024-05-29" version="1">MVFFTRKSKSVESILLVLLTVFVLSCAAVFEQKNGTTSQSADEIVASIPFPGAQWIERMATPETKITLENGETYSSAYAAVLNGEPLANPCRNFNAWVNSIFIGPKTASRFVETMGVEWGHYLLCYLRNMIAGTFIYYATAGIFHYFCYVHPMSKEIFKNRKRPDSAIIWNQIKLSQASLFIYTMLPVLDEYLIEAGYTKTYFTVDEIGGWVPHIATMAFYFACVEIGIYWMHRTLHTNKTLYKHVHLLHHSYNKPETLTPWASIAFHPLDGILQASPYVFLLPFIPCHYITHVVMVFFTAIWATYIHDAMDFNIDPIMGSKYHTVHHTHYIYNYGQIFTFCDRFWGTLKIPDGPTGVPAKRKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYF9</accession>
    <name>A0AAD2FYF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS16360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1956713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="299" mass="33251" checksum="B18725BFBC16C1DB" modified="2024-05-29" version="1">MSLFPYKLHELLTEMQSNDHLSSIISWTQSGGAFKIHEPLVFEEILLQKYFPRQTQLNSFKRQLLYYGFDNLGDGIFAHPCFLKDKRHLCGQINHTNPTKSQREGKALISSRRVRGKRAKHVIRERLEASAASAITNTKKEEAARTTESAPAFIPSPDPLRSGGTTSPVLSVPLSLVPPLASPLARPGSNNRQGGCDQPSLIPLLLHSSREMPNQYWSRLNNSCAPLSRMVSNEDHCLPASTVVSMEGQNLPLSSTGISSMFPRMKQMPSGLTLSNGPPCCDVVSAARKWRKCWCRKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1N0</accession>
    <name>A0AAD2G1N0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1N0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF7">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="559" mass="64527" checksum="B85E14F8023BF005" modified="2024-05-29" version="1">MVKIRNKLIRKGSTPPQRKHWLRRKYVSLAWMVVFGALCLWVMTLLHQTVLKNAREQDSSALHSSLVDNVQMKSLSKKIIERKMKLRKAPTLEENSALDEASSSSVSQSVGESSDKPVDKNKYHLAFSTSCSKNDWQSYLFFYLAMAFEQPGDVTHIVSGCKDQETEDEIRQMHLEQHTKAMNENFYVHFTPEFSDKRNFQVTKYWNKPFGVKHWLEHRFGFEYDKSKGEVAKPTEYDDDIVILIDPDMLMLKPFYNNFTSAPMSVWNKYFQSRADSLFYEVKQGQVISQEYAFGGAWLRGLKEEGKNLTYVLGTTESRVLGMSMNEASNVYAAGPPYLATARDFYNIAYHWTDFLPRYYEQKPNMMNEMYGYSMAVAHLGLKIQLAKGFMVSDVNILTGEGWEFMQETFPKDEDLLAHACDMPRYSRDSLPQVLHFCQRYGIGEFFISKYKVPRRTFTCEFPLYEEPPIDIATEVYTRMGNFQTTPWDATSGVHTAKRAANAYMVCSLYTALNKAATFFKDHHCEPGQANYDKVWQYFKVYDKDPHGPGGGGKSKSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G293</accession>
    <name>A0AAD2G293_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G293"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="32554" checksum="B5DAB6CC88523952" modified="2024-05-29" version="1">MMKEASMHTPPPSTFGSLCPKQQAETTMASSWQPNDRFDYLKDRLDKIDRAQSAIEAEEPMHNFTCSLLQLKDVRLQEAVVFKKGNETLLCQLEEIGAIPTLLNAIERFNGESSPEFNNSACIAIVHFAFQSKERSCEIFQIGGFQTIVQMMETYRAIDFIQIIAIAALMVVGKNSGIEKYDLEWTILHEIVVAMEYHQESSHLYIVACSALGSLFGPNSMTMVPETDAGVELYYRAIDAICFGLVILHLDDRVAQKLGKDLLFCLVGQQVAEEMMFYVESSYGVYTAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2K6</accession>
    <name>A0AAD2G2K6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type E3 ubiquitin transferase BRCA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS18736</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2K6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031099">
        <property type="entry name" value="BRCA1-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="1125"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="368"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="591"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="871"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="900"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="943"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1960448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1250" mass="137252" checksum="55D3DFDEB2103F51" modified="2024-05-29" version="1">MSISDNDDSKKPNDDDDDDDDCHPSTKAAAPPNPAINDDQNQPVAAATSCHKVADLWQTVDRELRLNIGNSLKCGICLSTLTQPYRTPCVHAFCKDCINASLMYSGNKKCPECNTPITKRSLQPFDYLQDLCDAYKLTLREFGMVPAKYTPNFTTMTQQVCPSPSTNDDDDDDNEEELSPQDQLDRLDVATAWQQKALPLLASQRKIQDLQVEENAQVVDANFKACGDLLIPKAQLNSTQEVQEQAREQQLADEAWKQQQQLQEELAKKQQGNPTQDSSVFLTAPEESSLSNSPNNNNKRVSFSTKPPTNLGFVANKTCTNQLVVHTSHASENTEIPAEEDIITPKLTNVTFNKADTAFTVVVATPAASRKRDSTLFETSLSPIDPQASQEIMPRDPTAAVAAASSLSEEPADEEESLVTKEPSALVPLQPNNETSAQQDDDDESKKKKKTKPKKKKVGKAKGGTAVGKETENNSAKSNAEESTNTNSTTRRSHRRSSKQEAVDPTKDTGALSMPTPSPSKQMQPPEPEPQDEILTLSHNDTEESEEIPKILEQGTQMTQDDNATACFNTTAGAMMEDSFGALHLLPVKRKRKQRQLELSQSSQVSDDVDDEDQTAKDSIEDKATDLAEQDATKELLQNDVSVDDDWTVPIKSQSPESIHTKESSPQATEPELKTKTVRKRTSFGTATTTRFGAAAAHVEETTTTTTTIPLNQEEEEEEEDRKPAARPTITPRRRRRRKSGANESNALEEAQNTDRASLAPATPAATVNPATRPRVWHVGEIVKVQPRTWPGVNKLGGVARVTKVWEAFANCCYDVAYILGGKESKVDAIFVVESDDFDDQSQPQQRRRRKADATELSMAMLQDLERQGFDTTGLKPLKTPYVKRKRPRLAPGSALKDTTNSKKKEIKKSSDTKKTTANDNKRKANSSNTEAQKTATKKVVKKAKENPKTETKTKAGKSKAATSTTAAVKAKATVSAFSSMSLPEIFVKADDHYESIMDSAQRDGELYIVTSSLKEGEMSMLKEVCSKSLGNIRLRVTDTFGKRTKICVLPVEESEGNIRPQIRTVKAVRSALAGIPMVPPDWIAQMKDQKKFIVPNTFVRSLPAKAVPGKKGGVAQYAAGIKSKQHLLLKGTSLFLCGNFPDAQRKDMHLVAKEAGAVVLKTPQQAVDQLQQSKRVVVLCNTSNIAPVPLEKQLRTSLTADSQAALVVGPGWLFDSIASVEELPPQAFPPPETKQRTAMELWRLCCADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2Y7</accession>
    <name>A0AAD2G2Y7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CYCCA115_LOCUS17142</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001971">
        <property type="protein sequence ID" value="CAJ1958342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15614">
        <property type="entry name" value="PHD_HAC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031162">
        <property type="entry name" value="CBP_P300_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51727">
        <property type="entry name" value="CBP_P300_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAZ-type" evidence="21">
        <location>
            <begin position="439"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="21">
        <location>
            <begin position="676"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="20">
        <location>
            <begin position="926"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="CBP/p300-type HAT" evidence="23">
        <location>
            <begin position="1166"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="22">
        <location>
            <begin position="1571"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="21">
        <location>
            <begin position="1639"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="327"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="385"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="522"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="642"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="761"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="561"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAJ1958342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1760" mass="198684" checksum="106868A557CB1B62" modified="2024-05-29" version="1">MMAPFDGSVQQQQQGVSQASLPRPPMPPGHAGQSSAMHQQPMNPAYTHGLPRGVSAGIPPGGQTYQMRPQSPGSRHDSFQMPSASGPQGQYTSHQPLHSSGHQQQPQGGQIHPGMTQMHRGSSQSRNGHVLPMQQTHDNMMASTNGRNQQFMGSSMGGGMDNSMNRSMNNTLNNSMNTSMNTSMNTSMNGNSMMPMGNPVNMMGTSMNAGMPNMTMNPNIGGVGVMNVSNGSMRSSSTPMLNSSMHSGGGMNGSWQTDRDTQHRRDMIQHIVKMLKKDRNGSPEWLSKLPQMAKQLEVSLYRNARSFEAYTDMNTLKQRLQQIAAEVSKKARDQRDDRQRDRIPSSNNTNSNYIGMTSSNTSIQSNSIGPGSVANNNPMVDMNSMRGSPHTQMRTVGSSNFQDQRAATSSNRTSASRGMGNSLSSGTVLSSSGSSNRDDPEWRVRIRHKQQRLLLLHHSAKCPHEDGRCPVTPHCADMKRLWKHMEGCKDNQCRVPHCFSSRAILSHYRKCKDVSCPACGPVRDTVRRSQNRNTSSSNLSLGENRQSRTNMGEVQRMGADANTSAHPKLSSRANSYQPSLGNSFNQSQDPKPLMPPSGDSLKPQYPSTQSSSQNVQSSGTNNEVVGRQSLHFCQGLSVDSGAVDKGAREMPNGNTVVGERQQDKCPNPPTRRNDSEWQKVRHKQQRLLLLRHASRCQYKNSCPVTPHCASMKKLWEHIAHCKDQRCSVPHCMSSRYVLSHYRRCKDAKCPACAPVRDTIRKSHEKERQGQSAGLNNSFDTEKQGQGDSSTTAFDTGFADSSEISTSDDNQRSAKRSRLDQGLSLSVASSVTDVHSQNASKFDNSIKKETLVNESIGVKALQSLEGLQKEPIPNPATQNAQTSEDRSLLNSFSVAQLTTHLESLNRVAQLSPAIIKQKCLEVLKGLQAHQHGWVFNSPVDPIELGLPDYFEVIKKPMDLGTVSKKLDSCAYHEICDFQRDVNLTFDNAMRYNEDGTVVYGMAKELKDKFKEDNEKLFEQLKAEDWERRQNDRACVLCGCEKRLFESPVFFCNGLNCQSKRIPRNRYYYIGGNNQYFWCNQCYNDLDKNTPLEFVDLTVNKSDLKKKKNDEVHEESWVQCDVCEKWIHQICGLFNTRQNKEHQSEYCCPLCLLEKRKKDTSGTLPLRPPGAADLPRTKLSEYLEKDVTKRIEEKKQGSAGNAQSINAGSVIIRQVTSMDRKHEVREKMKSRYKHKNYPDEFPFRCKCIVVFQHIDGVDVILFALYLYEHGEDNPAPNQRCVYISYLDSVHFMRPRQMRTFVYHEILISYLDFARQRGFATAHIWACPPLKGDDYIFYAKPEDQKTPRDSRLRQWYIDMLVECQRRNVVGKVTNMYDLYFANDSLDATAVPYLEGDYFPGEAENIIKVLENGGNKKGGNAGKKMAGSAENRKSTVEIERDQVMVKLGETIKPMKESFIVAFLNWSEALKENMEVPEVVLKYRSEHPEAMVPLLTGRKRDANGNIRELDGPLDRNGRPIKVIDDDVEDLDCEFLNNRQAFLNLCRGNHYQFDELRRAKHTSMMVLWHLHNRNEPKFVQQCVHCNREILSGMRYHCAICSDYDLCEKCYKDPNTNRGSCTHKLHPIAVESEGAQEGQGNSNGVTAQQRKQRQRNLLLHIQLIEHASRCSSSSCTSTNCAKMKKYLTHGKTCKIKVQGGCRICKRIWTLLRIHAQKCKDEVCPIPQCMVIREKMRELQKQQQAMDDRRRLEMNRHYRMTITGTDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3U8</accession>
    <name>A0AAD2G3U8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3U8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042292528" evidence="2">
        <location>
            <begin position="24"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="24749" checksum="46AE538108C68F1E" modified="2024-05-29" version="1">MVNRGNILLGVILHSICAVGVGADDRIQRKRRGSLHSSQTAHQSSSDEMNSPIKTRRVQTTENGQCLDRFSATFLQFSALPQAIYNDPFTRNPQELGTRYIYNDNLRFLPSLDVVPGSRASGTCTRVQSRVGNDQIGLQLGMGHCEFTYRLANGDREVIFTATGEIVDSIGGALSITGGARSAFGAYGEAIITPVTVQPDGSVVSNEGDIFLEPNFYKVEATLVFPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3Y4</accession>
    <name>A0AAD2G3Y4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trypanothione reductase</fullName>
            <ecNumber evidence="5">1.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N(1),N(8)-bis(glutathionyl)spermidine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CYCCA115_LOCUS19170</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>trypanothione + NADP(+) = trypanothione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58290"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58661"/>
            <dbReference type="EC" id="1.8.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="17">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.12" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3Y4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015042">
        <property type="term" value="F:trypanothione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000051">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001864">
        <property type="entry name" value="Trypnth_redctse"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00470">
        <property type="entry name" value="TRYPANRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 17 19" id="KW-0274">FAD</keyword>
    <keyword evidence="8 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="17" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 19" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="21">
        <location>
            <begin position="7"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="20">
        <location>
            <begin position="356"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="53"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAJ1961385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="479" mass="51731" checksum="75D55DA92AE91D90" modified="2024-05-29" version="1">MSSSDEYDLLVIGAGSGGVRASRIAAGYGAKVAVIEPQLQHGAPNYSAIGGTCVNVGCVPKKLMVFASRYPDEIGLSGGFGWEGATTGSFNWDKFMEAKNKEISRLNRVYKDFILGKAGVEIIEGFGTLNGKNAVDVKSTATGETTTLKAKNILIAVGGWPFLPKIPGIEHAITSNEIFYLEKQPKRMVIVGGGYIALEFACIMAGLGTKVDVMYRKELFLRGFDMDVRLHLKEEMEKIPNVTLHFSMNPKEIVKKDDGSYTVNTECGASMETDEVMFATGRTGKVDGLNLESAGIETKGTFIPVNDYSKTNVDNIYAVGDITDRMALTPVALMEGHRLADTLFGGKDRPVDHKMVASAVFTNPEIGSIGYTEEEAVEKFKNVTIYKTSFKAMKVSFPGGSSKTLFKLIVDDATQKVVGCHMATNGAGEMMQGVAVAIKMGATKEDFDSTIGIHPTSAEELVTMRTPAYSYKDGVKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4A3</accession>
    <name>A0AAD2G4A3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4A3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="180" mass="19727" checksum="7F798B3460FEB5C3" modified="2024-05-29" version="1">MVWWGWVLLWIVLSNLILYCFPQLLADIVQFYTELFKCFFGSTQQQQQDPAAPGSSNTVALEEADALLAEEGNVFAQPLPSAPNLEQRSQESAPDEPNAVLIEIADVALVEDEDVMAHQLPSAPNSAHHQESAPDEPNAVPIEKAAVVLVEDDDVMAHQLPSTPYYPEFISKSVTPSLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4D4</accession>
    <name>A0AAD2G4D4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS19684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4D4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1962431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="65625" checksum="15850D2234F96170" modified="2024-05-29" version="1">MRTRAQLCHISSTLDNDVAAIVVQPTRAQDFWQRQQGFQRNIYSPGSLQFCGLAHLNIAPSFAPRSIHHHTRNLSTLNDPSTNVGADYTSVSSVLDQQVQEGNLRQDKAQMQLAKRLSRLQKALVGYDNAILFETEEESDDRKDDVDDDEKTDQVNKEANDEKPKNQKVKLQIPRGLYIHGPVGTGKTMLMNAFYANAPTTTLNENGSNSKKKRYHFHEFLAQVHQRIHQLKQQDLKEHGRNFAIDTSVSNNPIVKVGLEWSEQVSLLCLDEFQVTDIADALILSQLFGVLFRHGTVVVATSNRPPQDLYEGGLNRNYFLPFIDLLQHHCITHAIASPIDYRKVLSDRTSFFLTKGRDEEEDPQTAVDVMLQALVAESPGEPVVPTPMTLAVGFQRKLEIPLTYTAKPPTSSDDNATNVVASSLKVARFGFDELCDRELGAMDYRAVAHNFEMVILENIPVMDLEGHDVARRFITLIDELYEGDCALLCSTLEGADEGVTTPMDLFSGASETHGPSKETIQQKQEEEDKKKAVFMGVDVAQEGGLPVGALASVRELSFAFERSASRMFEMTSRPWWDRVLGFEAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4M0</accession>
    <name>A0AAD2G4M0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4M0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36223" checksum="16D956D9360667B5" modified="2024-05-29" version="1">MRISSQQAYAGGVFVGVMRMIGTVFKVLLCFFAIYRLLAWPPLHWFYDPVSHAGPGTIYIPGGGFSGFWFHLGYLQSMKDLHEYEYYCFSSACLGILAVLMDHTADDVMDAALLAQERWQDNHISRFDLVENFLETLVPTSDDDSHDQEQLQQILSKIKILVTTTENGVEVLQATNRDELLDLMIKTTWVPALTGWGFLTDHKDVYLDGGFSRYLHPDCEYVLELPMVWETLVHTFTPSLTRETIRELWNVGYEYEYGFQGLSKQAKEGFLITNDDDDEEIYLQRERNDTQHNDTSCRSETMDSVQSSSLLQMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5B7</accession>
    <name>A0AAD2G5B7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1961992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5B7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="468" mass="51602" checksum="5315F0E96CD88790" modified="2024-05-29" version="1">MSEEGEKKAASQEAGDANREERKSRSNKHRPSSRDLVDDILVASERKSSQAKPVRRRSKDDDDDDDGLGDPGKRPSKPPSRRKSRDSHDSDELGGSSSRGKRERKKSKDSMDGIAVGVSDRRSIKSPSRRKSRDSNDGAIDTSKRSTGHHRSRSRDSNDSLANDQEAKIRVRRKTSGLAMPGAFVETKGVNRGVRRKGDGSKSPLPISLWTQLCLNLTSSRHRGAPCRSCAANKKSSMISSRHHNSPARNSDTNENEVILSPIDQPGSSVPQRTGNVEALEATTIDEMKTAHRGEKRDNLVFVAAPATSDDDKSKKYEYIFAAFVIFAIAVGVIKWLLVAGRPQEVNIFVTYDHPASEDCRAMSQGNETKDQIGTTVKYFGAGMEFGVAPSIDLDFLETELQLRLQRDALPEIAGCDRRSSPIIENNIFVVENAVLRSIALEDYAICSSNSTRMCSPVCLEHDIYSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7D4</accession>
    <name>A0AAD2G7D4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7D4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1964993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="199" mass="23233" checksum="469BFC646055AD1C" modified="2024-05-29" version="1">MTTKTAEKRLKRIRRTCPAKVQERMSRATRENMYLTERPSVDYESLKCEFTLLGSTGNVYDITFGRLPQCTCPDYRKGNTTCKHILFVTTQIMGISPSDHMSYQMAYIGDELEEMYDKMEDKGNGKAFMAKKAVRKEYNTMNNDSLESKMAKMRLSCSSRTPNDSDYANLGKLQGQRSERDTSTYNAYHWEKYPYRRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G854</accession>
    <name>A0AAD2G854_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7640 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G854"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056057">
        <property type="entry name" value="DUF7640"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24646">
        <property type="entry name" value="DUF7640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7640" evidence="3">
        <location>
            <begin position="645"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="819" mass="87595" checksum="C412609ECC6BE6D1" modified="2024-05-29" version="1">MTDNNIRQLSSNENSNQKKMPAGDDHNPRASSSRASRRSVAEQEAKRRAAPTSRSVQPGAQSSNRNSEVSVEADLESRNNNRRSHHRDGHHRHSSRDEPRESSLRRHHQSSSRHTADRDERDRESKRRAAGDGRRSTRVGATSIASESKDGHRKRREDDDRRSKQRARRNDSSSGASAVVPGASHGRSGPEDARERKLREAGLGMDDDDKATTNSKDNNSEKDGIQRYPDLGHGVNGAAPVGIAPDAASVDDDGAIQIQATLVEGDDDEDNDAEKNIQGTMARENERLQREMAADNERLRQQMEEDRNRLREELQQSNSNQGIDDQDSKAKKKKERVIFLVVVLILVVIAGGVGAFFGTQGSSDESAAASLPATEVTNPPTVGTTPTQAPIAPPQATEAPSDEDCTNIANADPVQGQDEAEVYQFDTILEMTLTSQTDANIALPILQEQMQSRLMTKISGCLPDQRRGLSLRATTKRRQLQGNKYVVLNAQITSMSILEGESCKGNAGADCSKVLAKMDLYLQGEEQQFLLIDRLIRLFNSGGGDEDDDFDLARSLGLPNAVASLALASISSNDPTPAPSPTPTDLPTISSSTVPTTKATPGPTPPPTPGPTPGPTPPLTPVPTPDATTRPPRPTPPPQEECTDICRGDQACDNFDLELFELGCGSCIGDKSCLNAEADIGEKSCRNGGCEGLSGEVGDFSCIGRGACIKTVDVTIGDNACTCEGCCACIRPGDTVPDGSCTAIAESAADIEYIPFETFEQVEFCCLERNGGDNVDDEGDEADFEEDDGIDEDIDTPPPGEGGGTAPPGGGGGTLPPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8P9</accession>
    <name>A0AAD2G8P9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS21988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8P9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1966404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35145" checksum="DD8CF290F88DFD27" modified="2024-05-29" version="1">MTQLDIESKALDQENQRSGFDEKARAREEKRNANEAFVEKRISASTGHNPRKSSSSRDSISSGKRRSSTEGTRVEKVDRDIFRPENHGRDGQQPIEEPVGAFSVREREYSNSIRNNEAHVEPSENLAIASVVVPDENIADKKVNDTEKMNSIENKQLSPKSMAIFAIVALVVIVIGVVAAVVLTGEEENGGNAASVSSKRKTALLIVDVQDCFIGSASVTANGQVGSLPVAGSEEIIPIINRIRDEKSCLFDLVVRTQDFHPTKHISFASTFGLEPYVHITGGKGELELKCVNIGEGSCCPEALIASGIFAPTELKWSWMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8R5</accession>
    <name>A0AAD2G8R5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002242">
        <property type="protein sequence ID" value="CAJ1965975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8R5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="267" mass="30568" checksum="CF9A09E98CDB595D" modified="2024-05-29" version="1">MNAHHEHKYRPLSPLPEPISCLVVLVGIAKHDCHDMTNIFLFLETNNVLLPSDICSALPPIRLHKRLVLPDGEELALPTITKSIDLSDGEELTPPRKIKSRDHKSLKTIVHSSDAESEIEDVLLEEKDLIGRTFLLSPDDEGYDQRAKIVELNYKHNCNTDIQPARIQLCLNIDKGKYVMAYHEIHKWSETDKDNPIDTKLKQVVCHHHYIRLEQPSYYLGLTYSMTIGWKHGENTPEPLNITGANESVTYAIYSRNHNLPTRKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9A7</accession>
    <name>A0AAD2G9A7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS21982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9A7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13853">
        <property type="entry name" value="CuRO_1_Tth-MCO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF518">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="76"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="173"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="350"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="56139" checksum="EA0A175DBE69F659" modified="2024-05-29" version="1">MTSINPPTILSANGTLSTTWSLESATVSIPNSNIEITSRLFNGQLPGATLRIQPGDTLKINFQNLLTDNNGALGYVHNTYSAADETNLHFHGLHVSGELPSDDVTHVVGPGESYDYMTTLPDSHLPGTHWMHPHRHGSTSLQVGAGAASAIVVEDPPDFLPDQIANAPEVMFMAQYFHVNELNRIQEQSNDQLTNIRNAPSNEFTLVNGALQPTISINPGEWTRFRIIWSQWRNGNLDFSIVAQGGCEMQLLAKDGIYIRDYPRAIDMAPIVPGGRADIMVRCRDPSTYYSISGQGGTLATIVTTDVEVESSDLEAWEPPYPAYLSDLRGATVSPGCSCTTEFDGTDTVNGIAFEYGLTLHTSYLGAVVERVMGGQANEHPYHQHVYPFQLTTGYNNNRDAYNQIGDWHDVVMGDGTIRYSPTEFTGKLMVHCHRLIHEDLGMMAMEQVGEQEGGTCSCTAAPGLGLGAIIGIAAGAVLIVAIIVGFCVYRRKRRIRAAAEVADNNDLELLETEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9B3</accession>
    <name>A0AAD2G9B3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9B3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042012188" description="Subtilisin" evidence="1">
        <location>
            <begin position="21"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="70750" checksum="C0A9E80D88A99757" modified="2024-05-29" version="1">MKLNIILVLVIGFAAPVARAECRTCPDGIEFRDADPLGDGFYQCTNVDNFYLFSIEADSAECFGAQYDVMSVCCPSQVKDIAKDNACGWCPNGVTNLESSVEIPFQEDPVTCGQVMVLVAAGSLELGICGLASSVASICCPGDEGGGGGGFFSCGFCVDGIEYPLKINPEAENFTCTQVQAASLLANETVCDTLVKPLEDSCCPNTNSSSECDFCSDGLDNPNAELPLTGITCEQFQASAASVTDSTQCEFAFKPAETLCCPSTTNVVGCDFCSAGLENPTAPVPFVDELTCQDLQDSALFATDCTSTKLAEAFCCPSISDNTDRCEFCPGGLDDPNEDVPLLGGLTCKDFQDGASFVGNSTECEESIKPLEGLCCPNATDNFQCDWCSGEAGVEFPELEFPGIGLKCDTIVMLVPAVTYEELCDQYKAAESLCCPASTDAVQCDFCTGPSGLEFPEREIDDSGLTCQAFATLALAAPNQTFCSSFHVAEELCCPSSTGVSLPPVAMGDYCYICGSADVEMTKPDFQPYAFGGSDDPDDQKTCAQLEESLNAGRSPGESCINTISGFTFRFSPSICGCKGVTPPNPCDLCSGRSVNRDAQMPGENFTCGEGFDFIQHVSPAFCSNPEINLYGMEGVCCTDILESETISAASCCTRCLVAFASLFIGLIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAJ8</accession>
    <name>A0AAD2GAJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="597" mass="64448" checksum="469092689493A2F0" modified="2024-05-29" version="1">MAAITQRGKRKTAGKRMSSLVGKAQEEDDTFWGHDTWADDGDDSGNESFRDSDEESAAKKDEFDSDFDESESDREEEEKAAGQEEEQELKRQERSKSKGKGYMEAPTNRGITKGKGKRVVGDGMNAGIVLNFPGSKGGGAPLPTPVGAPLPSTAATTPPPPKKPSPKKAAKRITMASTRTKRSATTNKRLRESTAKASEESQTSAKKATKTGTGTGTGGSKRSGKRRYTQEEMLLEAVHKTEPENKRWLLERKRTKDIEDSDRAAMALREKKKGPVVEKYHSKRGSLKTLTYPNMDAVPELFTRKKVVLKKPKKTFCVVTGKRARYKDPKTNLGYFDLPAFKELRRRMEANEPLDQRKKPPPKAKPATNDTGSNVGKEETNTAGAAPKPTPNGVPPTDVAPTTPKTTATVKTLPGNASSVPNVPTLSPSGRRMSPRSRKPTEKMRENIASSPQLNNLVKLNVSNPANPALAMPADSINNTKSSSTVPGPVPKPSPSGTNGNAKKKSTTTQPTSEQSDQKTTSVGAKVKHATPPVKPKTTPTESAPTTKPPIAAKPSGGETSSSGNKRAVEGQKEATQSQLIMQVINDFNQQHPEVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAQ3</accession>
    <name>A0AAD2GAQ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS22780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1967448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="247" mass="28064" checksum="5F7A5314790455E4" modified="2024-05-29" version="1">MASLTPLSKSDEVVGKSMNEGYMNGFMVFVPSLGAMYMALKNPTFRKVTNVQSRTAMVIMPALFAFAFVSETKLIDGMEELAAETESNMKTVAWAEHVKNNYAKDAELHDLYRKSVMESGVRMVPELTPFHQAANYIQMNPFKCIAGFGVPAVSAIYFSESRKSHLPQQLKILHTRVFGQATVIATLLGIMALKEMMDRGGRYITDEQVEERVEEMRATRERMLFNIDEEAKRFAEQRQHNHDINKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBC3</accession>
    <name>A0AAD2GBC3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002369">
        <property type="protein sequence ID" value="CAJ1968185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="301" mass="33293" checksum="963F71C5BD855350" modified="2024-05-29" version="1">MNTLAILSRRAALTVARTQSQSSCVPRMIPRMLLSTSTAAAAPPQPFAVESPEGPSDLERADNLDWDEFAVDYEIMSGHNIKIKEDRAAAAMRGRTAAPQPFAVESPEGPSDLERAENLDWYEFAVDYEIMSGHNIKIKEGRADAAKTFAVESPDGTTDAEMMDTAQWDEQAIERELKSGLASEIIRDRKEAAKVFAVESPEGPSDLERADNLDWDEFAVDYEIMSGHNIKIKEGRAAAAKVLAVDAPDGTPDAELADIAQWDEAVIDYAAEHEDLAEVHRIHKLEQDVRRETALDAERIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCH4</accession>
    <name>A0AAD2GCH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002435">
        <property type="protein sequence ID" value="CAJ1969866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053019">
        <property type="entry name" value="GATA_zinc_finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353">
        <property type="entry name" value="RAB-GAP/TBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="260" mass="29887" checksum="C2F6FD136917FCA6" modified="2024-05-29" version="1">MILQRPLSPTIEKSSAFSNNNNKNNNNNNKVTMLSHNVVMLQVIVPARDVVRCTKQQQQQQQQQQQQVLPTATMIRRVHFSADENDSQSAPHKEELTSEMVQDMWYTPTEMNGFKEDAAKSIIIRQRRNRRPQELSDDDDEDALGLERYYEPKRDEFRRAAIFYTLQAQTKSRGDPNFIRLIARKCSDFARAAAVHQGRKDFDAAYKNKNNNNNKNNNTNTSNNDSSLDTQGKRQRNGFVCCTTDAEEPSAKKQRTLCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDP0</accession>
    <name>A0AAD2GDP0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002407">
        <property type="protein sequence ID" value="CAJ1968812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="341" mass="38292" checksum="7892E082D47DF378" modified="2024-05-29" version="1">MYTKLTTGSSNGAMEQPPIDEFGPVRDRRDFEPLQLSLKRILPCPSRELSFSVRGGCWRYTPSVAFGDRLGSIRESSAMPSTKNTISNAWGDSNSSNSFHSTPDEDERRTRKRLSGLNLEEHMKRHRTEENAEENTNSYTGGKSTTCRTAVTVVSESTSSSSSIRKDATVNATVTVVSDVVPKAVLYSLYGKRKTQIPNKQYLTWNNGARTHELKFSAIFVCPISREVFLAGRYGSFYQQDGSIIWYNKKSLAEHAVAARAYDCYMLRDGDVNSTPLKLGIDPPYHIHNQPPLPREKIPRPILAALDSMRNMRSPQRKNQMPTVVRPTPPNKNINPSQCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGB9</accession>
    <name>A0AAD2JGB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGB9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="340" mass="38910" checksum="99C8E1D1C69F5E1A" modified="2024-05-29" version="1">MTRQLVEEAFGSNNTSIDLYKDVLQCPKDASNAQLRKAYYKRARDFHPDKNKEESAKLQFQAISFAYNYLKDPERRKDYDEEGILPDENDMGDNGDDDNDKPNDWKAYFDMIFGKLSSTKKIDDFELKYKMSLEEEADVLKYYEQFQGNLVKCLEFVMLSQDRDVKRWMEDYIQPAIDEGKVTNYEANLKSSIGKIDKKLAREQKKNQSKQKKTKTKVEEDEEGEEDDEEEVAIDEDETESEDSEDDKRKSKKKKAAKPAAKKAKPTVTKRRRQVMGGCGPSDGLIAAIRGRQNSRNSGGSENLFASLGARYGVDMGDDDPLDDAAFAKIQSKLKKKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHK6</accession>
    <name>A0AAD2JHK6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001785">
        <property type="protein sequence ID" value="CAJ1951536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="385" mass="44948" checksum="DC0CB4A2ED6A1439" modified="2024-05-29" version="1">MKVIINGTALDQNPKHDAPIPLYKEVSKWDHEAEAKIKQKIRRNPQNATPTYEKEFTPWDGDTVEDYCQFRFTWNELEVGQALNAPGKHHTILSILSGQAKENWQTAVSQLPDDQQTTQQGFDTAMESFALCYCTLDARQKQRRFINKALRLPKNMSIRVFWNRLLFMFRCYQHLPGTGTTPTPEHRREILIQCLPRSVENDMTRGDYRWDDPNKTEIDLINYLTRLQTIGFSEKRSIPTKTTVTKKKTEYRNFKKDRKNGPNKKKICDYCTKKKGFTFYGHTEDQCNNKKKDLANNKEEKHNIEPMDVENENDVTTRFGFSMSKKEISKKMFNEGDSNAKEMASLCDEELTEFLNIDDNDDDDVKLVITQRNKPLPRLTTKGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIG7</accession>
    <name>A0AAD2JIG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14554</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="125"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="314" mass="36635" checksum="5BB5611D29D1CEF7" modified="2024-05-29" version="1">MAPGDSQANIKKKRKTEIAAKEKVKLVKRFKLFKLNYDDVENLSVSLKPFLTELEKERGPDSTPTDDAFRRWIKNVDEGKWTEEMSQKRNRKPKLKKEIRNIVSEDETNSLTDSEYVHGVQEFLTRLPQLPVIAIERCQESDLTEYYDHLWSQPKVMELYSEGEVRSRDYVAGRLKTWCKRWDDNFPFSAFTVRLPDGNNTFLGCMILGLSEEENTAEIAGLLRQEYWRKGFATAGMIHLLAHARELFQDRKKVADGEPFERIVATCHPKNIASQFLLESQGFHQYTPPIRWRADRLYYALTIPPVIRNFTDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJG9</accession>
    <name>A0AAD2JJG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="203" mass="23631" checksum="4B1DCD2B04EDB9DF" modified="2024-05-29" version="1">MTMKPENDPTGPIDMDTCEPWEETNENEEEQKHLKGDNHHEEEDEPKHQQQQQQVIKKKEYTKTSSRPFGSAFKHLIKTKRLSILLKRITKHHVDHGNTTDSDMSMSSGPTTFDHAEDPTTMIENNEPPVFHYKEGIKSPLLKNVDTSLYDNRLLSPSIVVDQQQQQQQQQHHHQLGINNKQRQHQQPSFRHYLPMDGMVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJV0</accession>
    <name>A0AAD2JJV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038983">
        <property type="entry name" value="C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057815">
        <property type="entry name" value="C2CD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056430">
        <property type="entry name" value="C2CD5_YbjQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056431">
        <property type="entry name" value="C2CD5_YbjQ-rel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412:SF2">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23025">
        <property type="entry name" value="YbjQ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23028">
        <property type="entry name" value="YbjQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23128">
        <property type="entry name" value="YbjQ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="YbjQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1316"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="775"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1956513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1335" mass="148096" checksum="95D99A492C57F2E1" modified="2024-05-29" version="1">MPSTVKVRVKGGRNLSASSSHSKFSSGVSSGLRSVSALIGSYVIVTLGGHYNIADEEEGKGKQKVHSTRTRICRQSRYPIWDEDCRFEVDDKLLQDEPLIFRVCHSDSIGQDELIGLVYIDLNPLLTQTAIRYDDENGESKIDGWFPVYDTLGGITGELNLSVKLNFIGDENPFRDSSAGVQLLHISTLDSASGFEVTHVFGFVEELIAADDVEYKWSENFRRARVSHESRQTLLYLLDASVRRKMCKTVLERGGNAVLGYHQNFDMEGDSGIVARSYGTCVRIERIQARPQSMSSLAPHTDSEREDSRPPLPRPMPEGHNRVASSTRFNLNPPEDQDDDEVELLTMTDFDPRVRVRIGGLVTARSIKYLGNLASKLSDQETRDSWWQELRAEIRSHAKVLCCTHVIGYLEAVTIYDDTAILSITGTACTIRGLPDLSLQRQINTWQDPTWSGVDDDILNDKSGRGGNEALERRYRRTSEMKSQTGDDSSIEKGAEITLPRKVHGKRGVIRARAAKPCSYAHVPYHHKLAPFQNMKLVPCLCCGKKWVPECLLATCEPPSRLPIRGSGVFVQARVCRSRQPSTGESDALAVSEALPFLEYDLARQLMLKLKVSGRNAAFSLKSEVDVGRSLIVATLTATAVYCSAMPAPRVLEISRTIAVQDEEDHQLVELQNQIEKISAQNRQRLSQAADRHLERIRKKYSSARQNSRQKSWARREAKWKREGRKREKERRNSEDDLHLNDDTPLPKSLHLHSSQLSTPTEAVPEGSERHDLLDSSSSSDSSTSSSSSSSSSDSESEKESPQKEEAGKMNTESSVGSNRDEMSAEDRARGKLAQSFETGFASGTDVSGHFGGEDDLINRNSGHRGVETIVPGDSDVDLDIDLEDLDNAGQLATRKGQRRRRRRKYRDDKAPFVLEIDDETDEDFLSVLLDKNLPEGIRMCTSQSMPEFGTGIGSKPHQRTDGQIVMSMLRFQWDSSALRGTRSNQFFSSLFQELFAKLCSQLASYSPAIVCGVRTQVNLTPDDMIELICTGKVVLERTGTRLEANGDDSDSSVLEELKLRKKEDLEQRELSREIEKGALLLTSPTPSISQNRATVIVDKLSDEMKQLHRSQAHQDAHAVQSARANTNTVPPIPPDYSFSEPFTISESDDTPLSPRSPMHSRHKSEGRTRVANSSPAAALARIRSVPIGHFAPSLKQPLPPTAPTPTVIAEVPVELTPLYYISDASVVEYLGTVSMHFVRESSGLEATEFNRFITECNAIARAHVASLGGNAMLAYRAVPAESGGRVYKSQVYNVISLSGCAVRVKYSQAETANGTNRSDAAENFAERRRRASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLR5</accession>
    <name>A0AAD2JLR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS19690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052941">
        <property type="entry name" value="StomDev_PlantInt_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48004:SF59">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48004">
        <property type="entry name" value="OS01G0149700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="8">
        <location>
            <begin position="409"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1962443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="626" mass="68621" checksum="E829333710A05A56" modified="2024-05-29" version="1">MEDTPDDLNANQHVAALPQAEVVTDIEGDVQDEVRRVIQEALRRRQQRQTPLAIVLPHVTAESQNDDESSNDDEDKNEKKLCGLSKWAFYMLMVVAVGGIVGGVVVAATSSSSSGNGTSSPTVILTPITLANLLYPDQDGKDLAPAQSDAIHWIVETDTFFQNPTVTDELLERHALATLYYGLRAYNWTASSNWLSGTTHCEWEFVGCNEIGSVISLQLDYMNVQLEYEYEGILKGSLPAEIGRLSNLNALSLAGNEITGQLPLQLYDLTMLTQLSVALNKFTGSIHKAVGRLSRLRSIDLANNLFHGDLPSEIGLLRQLEEMSLGNTYLSGQIPSEIGSLEFVKTIKLSSTNLSGPIPSDMQKLRLLELFDISGCGLESTIPSFSTSLKSLILNDNVFPTLPTELFLLGNLRKLFLSNTTLSGQLPSEIGKLTSLTELILSDNRIEGPLPSELGNLRLLLYLHMDDNMLASTTLPTELGNLASMVHLSFENSALVGSIPTEFENLQDLCYLYLNENQIIGPIPSVVGRMASLRKLQLNRNLLTSTIPWQMSRLSNLFSINLSNNQLTGNVPASMSRLEENIQDINLYGNNLTGGLETLFCGSLPDLQEFVADCELQCTCCTGCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLS1</accession>
    <name>A0AAD2JLS1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLS1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47821">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47821:SF2">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042099230" description="Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)" evidence="2">
        <location>
            <begin position="24"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33969" checksum="236D07CB7DA64663" modified="2024-05-29" version="1">MTTLFSLCFSAALFSASLQDATSFVVKDAPRASSRCMATAVVETVEESMIQEARDMDPQIVESMPPPLPSDLKNKYYFLRHGLSTANVAEVISSDRSLAYSNRHGLTPKGYEQGMASAKELLDALEEEGVAAGDKVVFLSSPFARAKQTAMACLDGLAEPENQERLRNEFGDLEISSKILMENRLMERYFGRLDNEAIYTYSYVWPLDKFNASHTAFDVESVAAVCHRLSEVVERCESEFENHHIVWVSHADVLQIGQLYGANVENVGMFSSYRFKNGEVRAMKRTPDSLPDPVPLEAPLRGTNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV61</accession>
    <name>A0AAD2PV61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS14408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001842">
        <property type="protein sequence ID" value="CAJ1953807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915:SF2">
        <property type="entry name" value="TOUTATIS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="491"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1953807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="625" mass="70401" checksum="03D2C08277A779EA" modified="2024-05-29" version="1">MDEISAEQGLLPSGPAGNDVEHNTCAIQDVDQAVMLIAKSNKTLESKTNRELIDDETFTNIASVDIQDHTNDKNTTAESHTIVLESQSQNNDATENENESLGTVVETLKPAMDTLENVADTTEGAEAMRWEKRFQTESESLKPLAGAVETIDETSQEDENERAEQLKWSAKVSHHERSAITDRIIHNGSQHIGVDPTLSSMPSHATQVRPKRAQRVSSKRSYVEALEASRVPETASDLWEAIRPVPEQGFEESLFSSARVGATSKRYSKRKKEKCKPESHPIVSNVVFNKRFLDFNRSPRGYLDELVRISKSAVLTKEQQSRPHYESIPIEPDLGDSASRVGHSYQARVSKSPKDYRDKFGDGYLPEYDTLWDPYRADAAERQGQDIDGFLNINCELVKKECLMTLLHLYDYNVAMAESEYRRIRAFGGEPSSKLSKEQSSVFKAFLMNEKKDFVVLAEKINRSKSDSLIHYYNWKRVDSHYPTLKAEWKNDFCFICNDGGDLLVCDGCERAYHLGCLKPPLAEIPEGDWFCPLCVNRKTKALPISTLSPSAIGNRLRFSEKEEDGSRLHRECNGIIWDKMNQQALGDSGNGSLRKPENDNPRSPDQVQMAPVLDELDAEYSVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVT1</accession>
    <name>A0AAD2PVT1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS16613</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVT1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="141"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1957230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22506" checksum="BF80363E1FDE147E" modified="2024-05-29" version="1">MVKVLALSVVRTGTELPEPIICSLATELSSFGFFQRPSVKEMITFLTKTFIKRTESGQRQSITHEGYVVHCYVRSDGLAGTVTTDMEYPARVAFVLLGQLLEDFTAEAGDSWKSCTVPESMAYPKGEEYLQKYQNPAEADKVTKIQKDLDETTQILHKTIDSVLERGVKLDNLVERSNDLSAQSKMFYKQAKKTNSCCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVZ6</accession>
    <name>A0AAD2PVZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041987193" description="RNase NYN domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36890" checksum="54575160CCAB60C2" modified="2024-05-29" version="1">MVALSHAGILVLIWISNLVSPEHDILRLPIASGFSLKESKSPTLERAAAKAEAKLRDFAKKENAIIVVDGNNVRGSAKFHWNPVEVHGRICSFCQGIGISKVAVVWDHGIKRFAASIPTNETVELDMVVVFSGLTQRADNVMVKESAHLAKSFCNEDWASLCFVTNDMGLQGRLIKRANANSPKMTCPRRPLLMGSTRFVEILDSYHNDGSYGCGIDKESCRVYKAQKSFEKFAKLREAKYNPSREKTWQRCVLGEELRRSYLCSYQDTEFSNIFSSSYIRDLEERGYLNPSVDDIEEGLAIRGPPRLDKRQWGMLIHYNQFMQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW85</accession>
    <name>A0AAD2PW85_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002001">
        <property type="protein sequence ID" value="CAJ1959463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW85"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="121" mass="13348" checksum="AAF113DC40B11CDE" modified="2024-05-29" version="1">MLAVEGGVQVSDTEVLRRPTRIRCRVEDRAVRRRTKGFGTMGPKPNTQARESPIGDEDIGSPAPVRFGFWRQTEPEEATAGGEFLLITVLWFQAFNSIPIEIKAFRGPEPPQPEGEVGKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWF0</accession>
    <name>A0AAD2PWF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal membrane protein MPV17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS18671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWF0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042183718" description="Peroxisomal membrane protein MPV17" evidence="8">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1960318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="28976" checksum="CB5EE5EE0C983DFC" modified="2024-05-29" version="1">MSHIIRYLASFLLLQQASSLSLPDVTAVTSQLSHISPHLAAHSFAPSDLLDGYKELLNSNPLPTKMLTGATLAVCGDAIAQSKDDNEYDKPRAASFAAFDMVYRAVQHFSFPIIVAACHGQYLGAIPLVGDIDVSQLSAMEQTLASQLGIVPFFYYPVFFSLTGAIQGLSVSGAMDRAKENFVPLMKRNLLFWIPVQFIQFGYIQEDLQIPFLSMCGLAWTFILSVAAGSAKSYTPEEETEIITPGDGTSKDDTSTVAPVTPIVQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWF2</accession>
    <name>A0AAD2PWF2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="613" mass="67255" checksum="3278BE3836FF78E4" modified="2024-05-29" version="1">MESDSETFYSLPGSGRKVRVPIKVKKGKVVSPTGVQNFDFDEDCPDDERMALQPAPSYMSQEGEETVLLEGNDEMAELEARRIKREMEEDEATHFTEGLGEEIIMPEDSDDEEVNALADELGGLSDHGTKNVAGMSHDKTESSEEEKKEEDVSDFEPARTGIESDGEAPKNSSGAESAAKSEATDIPEKAEIADIPDKTDDKQFVSEVGFEEPESTVEEDERAADEAKSAIVATNAAVETADDEQVASDDVVEEAKAEKEEYDAEKADSEIVATNATEESEEQETDEAKSEESVIDPVVKTQSEGKSLACSTNTTEETQEFDDQHENAASEQETVSQSKLQEDPALLVGAPDNEEETDIEEAKKGVDPPARSRGTPQGDVDEDSSIPEGPDDELMFVPAVGSASDTDYATASDTDYNTATDYATTDYATTDYGTDTDGGTTDYATTDYATSFDYDTETTREVDDSASVNQSVTHSIANSIAADGKGPRTRKNEKERSKWSLFGCGIVEEVPSTKQEWWNFVLDSTEGALQTVGGNHWDDPWAAEDEFDDDFDSYLNHNRSNRPRRRARSASTTRVNSRQAAASRTRKYRRASSAPRTRTRKALPKQDRRKQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWY1</accession>
    <name>A0AAD2PWY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS20161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="541"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="852"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1963436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1187" mass="133130" checksum="9A7E578A5FAC850F" modified="2024-05-29" version="1">MKGMWERAGDKESVDSGNGPSMHSNGSVGNDSHFMSMEDDSKEATSASSRRSFLKKQTSSSSNFGTKESRAISLLKGAVFVVVLLAVSAVAAATYVNITMEERDNFEDAFGGNAAQIVSISRQKATQVFSALDVLSTIISSEAGASNTTWPLIFVPDWSIHAEKLGRLMGENIELSFAPIIQESERELWANFSQETAPRWYRESIENEVKDTTVKDLMTKTLPYIFYYDFRNGFSPTRVTRSGVTLPVWLSYPLISENSIPLMETNLDLLTTPFATNLFNALSATKSPVVGVTQVLTDAKTSVAEGSIMQPVFERAGGKTENQTLVGVALLKLKWIDYFENLLVEGNNGIVIVLRSTCPNLDSNGQEEVIGLLSYEVNGPNVTFLGEFDAHDSQYDNLEISERLIDLQIDRTKLPPGICVPTLNLQLYPTKNLEKAFQTNKAAYFTTGAVLVFALTSTLFLVYDFFVRRRQRKVMKRIARQELIVSNVFPTAIRDRLYNQQQENGKEDKDDDSQHSLDPLGVDKPGSRSGAPIADLFPNTTIVFADISGFTAWSSAREPQQVFTLLETIYATFDKVAHRHGIFKLETVGDSYVAVAGIPEPTDQHAVIAARFARDCMKKMQETVLKLEVTLGPDTADLDLRVGIHSGQVTAGVLRGERSRFQLFGDTMNTASRMESSGLPGRIQLTKETADLLNEGGLSAWVVPRSQKILVKGKGEMQTYWIRKRKLLKLFHNSMDLVALDETVETEVDNGYDDDVFDPDNIAGMTKTDRLVEWNVELLASLLQQIIASREGSVEKQLSQRSLLKAGNVETGRTVLDEFVPIIPLKRFDADELKARRRPSSIDIGEEAKSQLRSYLSSIASMYKDNPFHNFEHASHVTASVKKLLKRIVSVDENGAFGKHDLPPEKRMDLVDLAGHSYGITSDPLTQFAVVFSAIVHDVDHPGVPNAQLVKESTRDAKFYKKSVAEQNSVDLAWTMLMQEEYHELRSCIYQTENDLKRFRQLVVNTVLATDIVDKELQALRKARWETAFSGTSNLERDVDSEDRKATIVIEHLIQASDVVHTMQHWHIYKSWNEKFFCECYKAYKSGRADVDPSINWYKGEIGFFDFYVIPLAKKLDDCGVFGVSSHEYLNYATANRDEWIRDGEELVQDFLRVKIDEQSDQMATKFEVAQFPLLLEKVTVKHICLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAD5</accession>
    <name>A0AAD2CAD5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SKI-interacting protein SKIP SNW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1902440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="3">
        <location>
            <begin position="234"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1902440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="590" mass="65199" checksum="01282DCEF094D271" modified="2024-05-29" version="1">MASLSLPPPKHSNNSAFQFGKPAAVAEEEEEEETETAIVFTGSNEPAPAPAAPSKPKKPLRAPCYEERCLAAAEIAKMTPEERKSNPRKLFVPRALEDFDDGGAFPEIHVAQYPRHMGNPHLRKKGASVNGFQTRSRAIVNVEVDKDGEISYDAIVKGGTNAGKKVFSRYEDLRGGEGKAEDLALPTEDEEKEATDKTQAALQKLLASKTALNNPSGSAMVNAETSKNMEAKTKFIKYTPRPDAPGYNPAAAQRVIQMVPKQVDPMQPPKHKHVKAPRGPAEDPVPVLHAPPKKLTKEERDKWNVPACISNWKNSRGYTIPLDKRLAADGRGLREHTINPNFATLSESLYVAEGQARQEVRLRAQVQKKLAMQERDKREEELRELANQARLERSGLAAEQTAESIDHPPTPEDSEEDEEEESAPRNRAEETEEEKAARQREKLRLERRKERERELRQENNMEIKKRKLEADRDVSEKIALGVHTGTGGAGEVDSRLYSQSAGMDSGFGADDEYNAYSKPLFDRQAAASSGSIYRPTRGETEYNADESYDKLVKGGTSKFQPSKGFAGAEGGADIRAGPRSAPVQFEKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCT6</accession>
    <name>A0AAD2CCT6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000014">
        <property type="protein sequence ID" value="CAJ1927185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF48">
        <property type="entry name" value="FAR-17A_AIG1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1927185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31113" checksum="C70B38CF868AD6E8" modified="2024-05-29" version="1">MSCGQRCGSEFKRPMFDIEENEGSLDINASFHIGKGLLSVVGIIKFITFAIAVVSLVYSFTVIEIPSFYPAFLTPWTVFFGILQLGGSWILTAFYSKDGSIYNPQNKNVLVKITWLLYSVAGVIGCCITILFWGAVYDPDNPSNDMFDKIMTHGGVVAIVLLQGNLLDRVPMRLKHIAFSDGLAVIFSIWLALQNTVIKYNPNIDDDDDAIYDAMKWRTETTSAIIQTVLVIVLVVPLFQTILWAVSLPKRRYLVEEVYDVDKGEVQEKPADQEEGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD12</accession>
    <name>A0AAD2CD12_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1907640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD12"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1907640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="10561" checksum="E8B2807E262B716B" modified="2024-05-29" version="1">MFRKSLVVLSKNKPRTIVRDPRKKRLPAEVSHHRALTAQQQQEQQQQIQERQQMAFEPSRQNQQSIGSTMGSYALAGFGMSIGFALVGALFGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD16</accession>
    <name>A0AAD2CD16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS1924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046834">
        <property type="entry name" value="ABC_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046833">
        <property type="entry name" value="ABC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049069">
        <property type="entry name" value="MRB1590-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149:SF1">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20446">
        <property type="entry name" value="ABC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21117">
        <property type="entry name" value="MRB1590_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase of the ABC class N-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase of the ABC class C-terminal" evidence="2">
        <location>
            <begin position="259"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="MRB1590-like C-terminal" evidence="4">
        <location>
            <begin position="556"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1930389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="71598" checksum="4AD5C6B964768BB7" modified="2024-05-29" version="1">MRLRPLIALTPIALQFRSVRSLSMSYRGGRGRGGSRGGNRGGGGGRGEYYKNKYGRGVRGGGGRGQADDTPRTAPGGGLYSDLINCLERLDGKSYGAYHDLDTPLDRGWVNSDFGFSLFVERAQSDPFAAPTRCRIIIDGATAAFPVSLYSNRIRSVALSDYLLRALHANCKKLGADEAMGGKGWSGPKGGDMQVLEPCQHVLEQSAVRVDERGNVVVQMSVNLPARGRNILGLAAKEIFAKTLPSMIEKSLLLKSLQAQRLQSHVDSIEDQVWLQKELESKNLIAFLRNGALLPRISGVDDRPMDSQKAVPFESPQRLEVSFRLPNAGTTVTGMGIPKGISLICGGGFHGKSTLLQALQVGVYPKIPGDGREFCVTSPNAMKIRAEDGRNIQSCDISSFINNLPFGKDTACFDTADASGSTSQAANIVEAIEIGANTLLLDEDTCATNFMIRDSKMMQLVAPDKEPITPFVSIVRSLYDEHGISTVLVVGGAGDFFEPADNVLVLDCYKCNDMTQRAKEIVVNAQDSRQALPAKKEFRAARQRSLIGNKIAANGKVKVLSQQRISYGESELDISFLEQVVVKSQSAAILNGLQYLSTQNHSNQTLKESLLALEKKLDSEGLSSLTPAQFNGGMSRVRMLEIGAAVNRLRRPNTLVQGQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFM9</accession>
    <name>A0AAD2CFM9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFM9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1926221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="520" mass="60431" checksum="8C8DE757CDA27A16" modified="2024-05-29" version="1">MLRKAYVLDQDVFSASLDIQSSRDLMISKRPDSQATIGIRRIRTATMGSSSSAKILPHENDPSTTEPNSSTDTTEHLPNNQTVVSSTILIPEHPDGQIWRNLNLIWTFRNGTALPNMTETDFNLRRIHPLTGTCPWTAQYRLKLHPGSNETEEYWLLQSLDNHSRPKTMGGDEMYVMYHHRNKTKAAPTAVAYSLDQGDGTYRLDFHTTPFTRRKDINFVNMMGRKGSKLLREGRYQPKGTSETGSRFKIDGGIFTLFMSYTCGLGELHHPAKKEWRTGGAIMRRYHTYVPYPPQMRVFQSPNADRKIDFDKYHKVMIFGDSNLHGLWRDNNQTIKNLHFIRKPDSALQMRSMKRLFLPKIQWFANLTMYEDDNPFENRYALMIGSACWDIVFPENSGPEFNNHLTALRYMLKQLKYTFGPMGNVDIYWHSGLALQLYVAGQEGGWFDRRPLKYMSYHRSFDLYRKQVELLKHVGNITLLDFMHASYLSGHQYIRGDARHVMPLLNRILLTYYYPSRLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG15</accession>
    <name>A0AAD2CG15_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000147">
        <property type="protein sequence ID" value="CAJ1931407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG15"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="83"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="344" mass="38400" checksum="FEAEF005DBF8693B" modified="2024-05-29" version="1">MNLKNPQTLQATLCAVFRDDDGYDASQTINSLKQDSPETYRQLLGDVLIASNVSWRQQTLNLIDAIWKEEAETRTNIPVQDVMKHPCAATVGSTKISVWKGDITKLEGKNLAIVNAANDQGLGCFVPQYRCIDNVIHREAGPRLRMECQKETNHRRTSLSTGTPPIVTAGYHLPSGHVIHATGPKVLKNNVDGLTSKDREDLKITYELVLETGSKTDGIGIRHWLEKHPESRLDQVVFNVFTNADWDLYPKHFPVFSTSAADITTTPSLRDRTIDLAKQWIEDADAVLICSGAGMSVKEGEMVYTNPDDFTRAYPWFLNGATRPATNVWGYQEIETFLQQPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH39</accession>
    <name>A0AAD2CH39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS3044</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel family. Plant (TC 1.A.1.4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000123">
        <property type="entry name" value="Potassium channel KAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045319">
        <property type="entry name" value="KAT/AKT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45743">
        <property type="entry name" value="POTASSIUM CHANNEL AKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45743:SF2">
        <property type="entry name" value="POTASSIUM CHANNEL AKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="510"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="756"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="858"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1932850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="935" mass="104929" checksum="B44AD31A8F4C9A52" modified="2024-05-29" version="1">MAGNVGSGGSAGSDHSRSETLTPETDRMQTDPTVGSGGSPVLAGKKRINGRRQLMSLRDASTAESTITTATDKSEEQAPSPDALQGSNHSGDFSIIHELPKMEAKSSHQPNRARTSSNGSMSTFSRSRRSGMAPSKTGKEVSNAKAGRTIFSNIHAKVQIQKIKEEHKKESNWWERLVIFPMSNFYRAWWMFTVIATIFTFFFETYQIGFPPGGLTEPTSPSSVMNYLLITVFGVDMVINFNLAFFTENDELVYSHRDIANHYLSFYFWIDLMGVMPFYLIALKISGYYQEDTHLTQWLSLLRLLRLVRMRRVKQLFDIIKFSSKVSLMSLTLIRNGVAAGVWTHFAACVFFFIAKQYDFDPDNTWIGPHEDQSPAEVYITTLYWSVVTFTTVGYGDLSPVNTAEQIFSMIYMLLNIILMSYIIGSITLLVVKNDEATGMYRANLQTLHNYCNANDMLDDELYPRLKTQLKVEFNHRDMGDEMVLSKFPKTMRQKVLYKLYSPCLEGTNLMNGIRQHFITDFLSACRIVIFSSGEELLTRGAVSSDLFLLVEGAVELSSPELTRASRVHSTHAGDEKGKVRRIMEDQDFINEISFFTESPQIDTVRTLTVTKTLIIAKSEYRVISNNHPGSVGRLLHNLLLKVKAIRDIQEQSHETSNIMPKLPKSVPVLFAGSEFDASQVSTYDESESGEKMPQNLTAAQTEAALASVQDLVEMHINRQQDDHTTRFLFAASRDDVASIRLMCDQGFDPDSSDYDSRTALMVASMKGNIDTIEKLLEYGADPHLKDHHGTCALLEAIENGHDVAIDILLNERTHPDMHWLDDARASGLLNQAVSDGDIQKLQRLIKANVNLDAGDYDMRRPIHIAASEGNMSAFRVLVEAGADLMVLDRWGNSVEDDAKRARNGKLVDYLNQQNLFRSDSRGNLTPLAEEHAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJS5</accession>
    <name>A0AAD2CJS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000413">
        <property type="protein sequence ID" value="CAJ1934921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="321" mass="35399" checksum="F18AAAF524056916" modified="2024-05-29" version="1">MLPPQNAATRPKSLVESVTPDQAPRTAPTARPPKRDGGTNAESITPSLTDTQGSGSQSDASTPSVFPIFRHPQQSPPSVPVKVEEFLSSLSPGDFFGDDHRCHLQSSTRLVFQNVNGIPALATGWKQQQINQWLKEEQVGIALLAETNTHWPSLLEGQHWNDSMRQVASKGYYSVAAHNENRARLMASCSQYGGCVATILNSVAHCAKSFGRDPTKLGRWAYVRVQGKKFAMPTPDDQVREASDASRSRFSRDLAVVSAYRPNPPGTGESTVWAQHQSFFRSQGRLREPREAFMVDLLRAITQWRDEGCDEDISSTKSSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK11</accession>
    <name>A0AAD2CK11_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK11"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="51401" checksum="56BA817DDC0E022B" modified="2024-05-29" version="1">MDEEVLKAAIQFVDELVELGVLRSIDEGLAVLTNAPLFVVGKDGQPGQWRGISDMLQGGQNDCVGQDPIFMPRIAHIVDQKYTEGYAAVVDLSKFFYNFPTYPEDRPYLGLLHPKTEELLTYYGLAMGAGNSPAIACRIGLAFVRLVKEKFGVFQGEARANCYWTGLQDNGFDPQLGYEFILTSNDGGAVHIWVWVDDFLIHGPTDKKTAQGLQFFLDTAVDYLSETKSCDIYQFIFDTADAQTPPFLKHSEFSNVNAVYDCIFALAHAHTPAETGTTAYRYEADRIMYAVTATSPTVVAFQHIFQALFVDSWDTFEKQTSTIANTELMKKFIALARAETSTATTAMAIADLDLTNPQTVQDIINQRVNDQICEKTKKLEQQLQTIQRSMVKNDVRGATRPGASIKKKKSTPNRQPSASNSGKQQPKTVAKAAAVVADSSKRKSTSRKKSLQKNKPSRNNSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK19</accession>
    <name>A0AAD2CK19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="199" mass="22455" checksum="676FC373C7530C6A" modified="2024-05-29" version="1">MRSSIVAARIFQRCEKRFPLQLGITQSQHCSMQQRNIVSTPNAAKTLLGINQDVKPTVKELRHAYFEMAKKCHPDVQEQSGEDGDAVVDFLELTEAYEYLLHNKNHHRQDGNIVISLDEEEAYRQACVAVLGIPAEIVEESKQNPMFRHWLGGNTDGAQHWRSFLSVHGGLAQRLRPPAGYIEGGENGGAPASRRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK44</accession>
    <name>A0AAD2CK44_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="199" mass="22973" checksum="D2770AA7165F6ECD" modified="2024-05-29" version="1">MMQERRVAFQDDRDVVEIPGRNDYTTDEISFMYFSSWELEIIRLREKRWALELSVYGGISSKHDDDDDSTGLESVETKSMRTQHIEIGIQTVLTEQELELIEGGYREDEYIAKIYRNATRQNQVLARHRGFDNAIQVKAGNFAERILSPSSRSTTITDCNPRKRDLDICRVGNPIESPPETARLSVRLSRMIVVPIDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKV6</accession>
    <name>A0AAD2CKV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CSC1/OSCA1-like cytosolic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000402">
        <property type="protein sequence ID" value="CAJ1934872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="658"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="705"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="961" mass="107822" checksum="F38ECF571FC87CD6" modified="2024-05-29" version="1">MPVTNSNGSENLDESNKSSTSTKDENGYSKDAAPSIDFLKDERSSMTYGRRIALSLMNQKWYNPQVEVKDGVEIDGSARTGQSGNPNTVVAKPSLEKAWAYFEHFALSRYLIDETADSSDRKRAEPGENDVPTRLYSPIRLPHAQLGDFGIGIGLYFSTLRLILFLAVLCGLISIANIHFFASSSYQSPSNRDSIFPSLVQGSAICTETNWVACPSCECASDDRVTAHTLRRQDILPTSRCQVREVDGNLLTYVLKNECGDIPIYVGMINYATIILFFLVTYVYLGIFLKQQETQFDEDEQTAQDYSIQVENPPDSATDPEEWHRFFKDNFGAHATVVTCAVENDLLLHTLVERRECLRNIELMLEPGESNDELNIARKAALIERDRSFFATMLALVSKGIPEYYSRMVSLSAKVKGLAQLSYPCTNVFVTFETETAQRDVLEKMSVGIVQAEKNIKTAVADPKYLFRGEHVLYVSEPEEPSTIRWQDLNVTQLQRIKSITATGAVTFVGIVVVFIAVSAADNVSLVAGAYTITAFNVAFPILAKALTNSEPHPSESDFQTSLYFKISFFRWVNTAIVITIVTPFTNTLLGEGGLITKVYQQFFSEIVVSTALQLTDIMGHVNRHIMAPRATCQDAMNLLFKGTQWSLAERYTDMTKILFLCVWYCSIFPGAYLMCAVSLFLKYYTDKFSLLRTWERAPHLGNAIAWISHGVFFPLALVATAIMSSYYWAGFPYDNLCPVGPLEDASYGGSSFTVDGNLEEFNDAFEYEYCRQNFFGRGGIFPFVSQIRKGGAKWMTDDQELITSIFGWSSVVFSALVLIKFLIAWVKVYRALQSSSYKAVGADKQIAFSTLDEIVGYIPQISSELFSFPLIACISEEVDPELYEWNDPDKPYVYYDLTEDARKLLLGSPFDYKDGFSRIQHYSPYREPLRVENLTSSVKPIDLIVTDDGEWNSVIAPIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL67</accession>
    <name>A0AAD2CL67_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL67"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="381" mass="43328" checksum="34B6E0E6D591C797" modified="2024-05-29" version="1">MIAGNQDTTKDQYHKDQQQEGQKSDDTGTTSQSLPPPPPPQEERMDASSSSCMESDDDSTGSDDVEKGKPKYGDVDSDTDDTVTLGDDDISHRPWVPMWFLNHGWQGVLAILIPILFVTVISSVFGHIFASSSQKEFAIDGQGGSNIDLSLVSRQNTTKSVSPTPTPTTSLPTVAPTTLMPSTLPSYSPSTVPTVAPTLEPVVSHDFMVRLYWHQDFYWQETYKETWWCMECAECKRFTLGDGWEGECVTPGSTPASCQEGDQIWVRRCKDERRLYTFEIIHNDGSGDQVRVHGTSLCFSMKNERYLELRNCDRTRPEQLFAPIEDTMKFELRPYDQRDLSDKEANCLSQRHHPKDKEMVGMFKCRTNINHETNYWTEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLX1</accession>
    <name>A0AAD2CLX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS4751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000469">
        <property type="protein sequence ID" value="CAJ1935426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042215339" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1935426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="668" mass="74139" checksum="26A21BB0E14BB472" modified="2024-05-29" version="1">MVVNRFHVIFDLFLLFSIAESFLTPNALIRKVDDMSSRLKVQHAKSGGRAAGSEDKITSSEEWQATPCKPGEARLTIIQITDTYTLEHLASVKTLLADTREKSQGSKVISMMTGDFLAPYLLSSVDRGRGMMRALSKIPIDYLTWGNHEADIAHKTVCKHVRDFPGVWLNSNMLDHEAMDAQQEFEVIDICSPDGTNSRKIGLIAVLSDDPGLYSHFKAPGAFGGATIDDPWMTLKRLQEKLHGPEYNVDTIVPLQHTYVPDDHKTCREFDFPVVLSGHDHHRVDEVVEGTRLLKPGMDSVYATILELVWPDGDTEGKKPKINASFVKTSNWEPDPALAEENERAYDALAPLRNTELARVPPPFEPLSSVNSRGKVCTMGIYICTLLRSSLNSSRRQRKHDIDAVVLMGGNIRGGQDYELGSFFSLEALEAEVKGDEVIAVVPMPGWLLAEGVAATHAGDPIPGWMQYDHGIVEDWSSGKPVITQVRGKPIDHKRIYRVATKISDLTNGQSPPWTEYYKQHPLLLPPKGAYVNIQAELMGYFAKNLWRKIWDSLTDSIGSECNVDAIDNDCNAEMRLKSLDKDNDGLVSVEDIQAALADIVGLSVDNRELSLAQFVHSFADTNGSGEVTLEDLQTFCDEMEEVYEADAWRLSFPKSSPPQGEPVEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN53</accession>
    <name>A0AAD2CN53_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS7062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000891">
        <property type="protein sequence ID" value="CAJ1940479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN53"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000014">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31469">
        <property type="entry name" value="OS07G0633600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31469:SF8">
        <property type="entry name" value="OS07G0641000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1940479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="67579" checksum="9CB1646713988CA1" modified="2024-05-29" version="1">MTKERKISTIKASKDGSVSRRHRTGGTGLNDFFIGVFGLCFLLSVSLNFLHDSGTIPHIHNTVVESAIQEFKQDKKRKVGPGENSNSEIRLAKLNCEKWGGPEIAAAQEMVYWEDIPSDETFVSPFCQQGKENFMTFEPDGGGWNNIRMAMESTIGLAYAMCRTLVMPPQKRMYLLGKGGKNQRNHFNFVDFFPIEEMAREHKGLNIISMKEYLETRAVTGKLRNAITGEVEFPPGNRTDWDGIDGQDYDVLRGYLRNVSETATWNPGQCLPAFPSSGDHKDVEVLQKLVQSARRNVPGGTPVKVDDPNPLGRLEETLAGRHDLCVYDERMQNLPVLHFQCNHKKRLRMLVHFYAFLFFENWKEDLWMKRFIRDHVHYVDEIQCAAARLVAAIREHVRKRDPNNTNGDFDAFHIRRGDFQFKATRIGADEIYENSKDELIPNSTVFIATDERDKKFFDPLRAHYDLLFLDDFKDELKDVNTNYYGMIDQLVASRGRIFFGCFFSTFTGYIIRIRGYHSVKDKLPGHEDGLLTNSFYYATKDRKLIMHQYAILRGGFFNREYPTSWRDIDKGIDTLENPQQVTTYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPJ9</accession>
    <name>A0AAD2CPJ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000707">
        <property type="protein sequence ID" value="CAJ1938352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="15791" checksum="5D4FC82D2A260129" modified="2024-05-29" version="1">MLAARDMDDGATVASAAKLAVQLEAMKADVSDLCGELETATSALKSTKAKSAAEEARIQELEAMMAHQQLVKGKLRGASPSSSKTNSADSGGGPITVVPNHQRSRQARLRRQTEGRIRNLRNQPSSQAAHSLLVAYLNSLSPGNFFGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQP9</accession>
    <name>A0AAD2CQP9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="116" mass="12824" checksum="0DCCB669122C7E90" modified="2024-05-29" version="1">MNQDWILGGGMLLAQSCFGRRDDWESQQSFVDLATLFSTPLDNSGYSDSVFLNPMALALFEDPAWYQSNYTFYSKSTFSLGAGHYFVGGICLNRQENENNGGMVAGVGTEIPNRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQZ9</accession>
    <name>A0AAD2CQZ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041931444" description="Phytocyanin domain-containing protein" evidence="2">
        <location>
            <begin position="40"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="24826" checksum="A54C53B887DD8C61" modified="2024-05-29" version="1">MSRTRQSSSSSASCLLPSYSTVLLLILLIQTCHIPSVSAKDLLIEFWSPTLDHEPLPEQFVTAGDTVTFKVYGPHTVFIHPSLSCDPSNRNELVPKQNSNSVTYTFQENDSDFFGNEMLFVCDAGSHCEQGQQARFRVFPTPQPPSPAPSSFLTRPTTSVNKPEDDLAAALPGVPIESNTADGTAGARTTNNEDAATTAEEQSSAFGIIIATRKSLFVAVLVTTMVSLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR02</accession>
    <name>A0AAD2CR02_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS8339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="891"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="961"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1086"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1167"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1256"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1943237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1291" mass="144666" checksum="C9483089FA443060" modified="2024-05-29" version="1">MSSRPPTPPGRPRTPTKPLTPPPPSSLAVQPPPPQLQKDVPTSTEQQQQQQQQPLENTDTKPQSTTMASNQQILPSSPSDKGSLGEPSSASDITMTNIMTTKPPSTTTTSKPAAPAVATSSNLPPATPVSPPTTIPNNNNNRNNQHFGTCDTCGIPTHRNRGMLGLWKKDVFTNEQVYQGTCIRCHGELVPPNVFLEWYLQKRRTSSRNKNDPKSSSISGGGPSPQDDALPTTTTTTTNFNTPAPSGLTTISNPTPGMPNNIPGTLMFQQTPSPSSATTPGGWSSIQVSASSGESTRVYEQGFQRPKKKMAKNSPNNKGTSQRFSFAGIENADSPTEQKALRAKYDRVFQLLQSCRTDLYRPTTDELDRLRLTEEDWRSIVLISNIDVGCRLLHWALVFKAPYPTIRFLLQRDVESSWTVQHADTLGSLPLHYACRYGAPLEVFELLLREDQGDEKKTIIHVDKQGWMPLHVACQFNCNTNIIKLLLDQDPQQKEKRSVTHRDNQQYLPIHLALERNVPTKTLELLLTADTQRKTIHGPSPSGFTTIADFAMKYDYQSLLSENSTKLLNFVVDEMNIHTACRFGVPLETIKLLLDMDSNQSIYKIDEDENLPLHCALDGTAALDVIRHLIRMDTSKSTLHQKNKDGSTPLLKIALREDAMAILSGFPSLIQEAEAISIVEEMNLAVKMKVDVSLELQMKHTKLVNTIWQRRDFENRPSIAELTSLGYSEEFWRRVVLIEDEDTGWLPLHWALAFGAPPSTIGFLLEKDYEQHSIRHGNLSGSLPIHFACLHGAPYDIIQGLLDKDVTRSTIHEKNNAGKRPLDLLPRNSDIIANLVKDARTMDMQPETLDFFFQSAPPSLLKRAIMDTLESGTGGTSPLEWMNYGFCQDSAMISIMLEFYLLITWIAAFVYASVCYLLDGYLPESLGIMLPILTVLVLTVKFRCAYNSDDFDSFFSNIKNVWNFCAIALVFASAIALNSATPKHDWRPLIIATGTFQIGTLLISLKRTFYSLSTLLGAVYQSFWKLVPFFFITGIVIVAFAFFFFVNRYNTDLDIDLEHQTLVGSLTFVFHIIVGRPDETLDWLDATFSILTILVLLNVAIAIVTQNWQVSTSRASNQFWVDRLDAIIEYRSRGTPSPNPANRLWEHVTASFHDGRQHESLFDKSRFCILYLDFFLVGLATCGYLWPQEIRRDLFYAPLNLGSTDGNQEMDLVAMLERKIQLLEENMEWNQRLMDRKMHEEFDDLKSLLVGLQDNSAKKPSKLSGSGNSARVDMSGKPQPFPPTEILVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRT0</accession>
    <name>A0AAD2CRT0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="193" mass="21677" checksum="815FEE8E99019613" modified="2024-05-29" version="1">MPLLSPLISKVAIHMSSQELQPYPLSKTSSCASATMFNILRTASTTTSHQTPWTTAEVDESVSPSRNDRVTNLRPRRVTFKPTVTVRSIPHFNRYPQSMKKKIWNSSAEIYWNARRNKIEFKAEGCDWRNVVTEDQMHVDVAMGELIHPCHVSSSSTQQHQHEVLEASGAGGGVVRTTLFPTTRKVQGELILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSR4</accession>
    <name>A0AAD2CSR4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001068">
        <property type="protein sequence ID" value="CAJ1941738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSR4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36991" checksum="8B60A2D067A0EBE3" modified="2024-05-29" version="1">MAFILLSIWVQLGSFFFLLSGLIGDLLLIRLFLYLAYVMLLTNALLGSPLWPKILSVDQITFSEVAMDSFVWAILSLYVHGSSLVALIWDERAPKLTDDEAALWRMMYRTGGLSARLFQDVVARHLHVVEVEAGDVVDTENFFFIIYRGRIELEVLEGKKFSHSRVLTSGEMFDLKSLGLVRTESIFDNSSVRCTALCPSKLFEIRKENLAKIAQNPLSKSLFQALLINNLMYIVESYREINHTRSEDDNYCSKIFDPLEEWEQPESYRSGSGKALQRPLRHIWKGIRGSFGLPWPFSRHPVGLRQTQLPPPLRRDEYQKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CST4</accession>
    <name>A0AAD2CST4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CST4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="213" mass="24186" checksum="31B7A55DA6DB4E91" modified="2024-05-29" version="1">MTETTFSQNIHSGRIPEVLHQHGIWRRPTMRPGSMDSLRRFSFAQQDIENSKAKQQIYNEDNSLESEFLPLVIILDDDELLQESSDESSSVPPSPPMSVWSCSMSSNQSEHFSVGFALCDPKNLRFYRDSNSTVTPSVRDSINTTSADYGLSVATSDSDSSMSQEEEVYSELLSICSDIPREIVVRKTLSQRFPFLRRLAPKLLRQSNRNLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CX87</accession>
    <name>A0AAD2CX87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS10665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001711">
        <property type="protein sequence ID" value="CAJ1946524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="1243"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1118"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1118"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1946524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1479" mass="158316" checksum="0458F54A511B2E47" modified="2024-05-29" version="1">MPTVYSDPEAGWGNDAPIGDEDKSQLTPPVQIQLNDPSYHHSDDSGSEWEEDISVEDVKGEGDMHGQYSRRKSSDELSHSTRSMPTTSLCVSMAGLGVGVPTNHEFEEVGSADGHSHRKRRHGSRKPKLQGSRSRSLSDLDANNDWDDAILPIQEADNDRRRRRHHGQHGHKRNSNVNSRGKLLGSSSRSLSDSDNSWDSNIVPIKKDAKNSGHNRNKRNNKSSRSKGNHQSRRRKSNSRSGSSDSRSMSSERHGNSGTRNIERHVSFSSSTEPSEEPIGIGESERSAVYLNKAAQKIQNRFRGARKAREEASGADSETDSFEETTSQESEAVEEDDIGHTITMAFILIFSVAMMSKRWIIKCFEGCRGNQKRSGRRQNNRDHDGHDDPEMVNPDEIPVDGNANMHGQAQTGPTTGPTAPAPGGMESMMATQAASSAAGGAASGVSAGIAAGAAAAGAATSAMAAAGVAASATQLVTAAVVGTTVVVASSVAVSNVLTATPVPFPIVSTCGIESPVFHNGAIGLSFEGFERGFNAREQQLVETLVVDSYNLITRGINQEGNNCADAYQREMQNSTMFDQVFNAENDENPSSLDVTLDSWVICNGCPNDLPMIGRYANAEVPSASRRLQNGEDSLNVKLDLDLLDQLLKEVARKIVDFADSGELAESFIPSKIALKGQPPSSNIDSEGEASMPLIFLNLPIGYEDPTSSNGREVIFPRTSVCGSSDPEFYPGIWRLSLQGVARTIATDEVRVIEDLMLETYNGVVIGRIAQPECSDRYQREMSRARLIDQQFIRAQGNDTVSSLEMTFKTWLICNGCSNAIPLFGTADEIENGNGFSYDSRMMEVALRDIIARMVGLINSDALSSSLLPNKVSILPPTQAGSNGNGGGQGTALEPLLNVRIIIETDENGDLLANVPKPSACGLFDPNFYPGELRMTFEGFERVFTEEEAALIEPIVLSSYNALTKGPNTEEGICVDEYKREMTNADLADQTFSVPPGGDEASVLDLVFETWVTCDGCSEEEAVFGSAGSSVRRRTQDGVGGDGLDLDFVEIHMEEVVAGIFELVRIGALPAIFVPDKVYVKRRGADGGNGAVLLDVPIIVSYRAQTGFFVQFPGPSQAPSMSMVPSSMPSDVPSLSMVPSEVPSDVPSDSPSVVPSDVPSVIPSDSPSSIPSAIPSSIPSAIPSMQPSSVPSAIPSDSPSEVPSSLPSMLPSTIPSVPPSDIPSVIPSESPSMIPSVIPSEMPSTAYQGCFVETPAFPKMDLLLGGAWNVDNCINQCASFGYRYAGLSISSVADHTCYCGNSFDTTAQVDDAECDNDCSGSCGGTVRTSVYIAGNHPVGGADGFTSDLYCDCHRDWVLTLTGTRPDLTNRVSTRASVKGCIALCRRDGYRYAGLQNGRECFLIQTSYPAPPKHAMIPSMIPSEMPSTVYQGCLVETPASPKMDLLLGAAWNVDNCIDQCASLGYRFAGLSTSGAHDSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CY80</accession>
    <name>A0AAD2CY80_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001025">
        <property type="protein sequence ID" value="CAJ1941511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CY80"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="523" mass="59529" checksum="681F7F16C025F934" modified="2024-05-29" version="1" fragment="single">MSCLEKGIEYDPSVRPGRGRQAVVKRGSVVEQTIANLVETGSSIEEATNLLNEELKEKHATNDCDSPLVLYSVSSVYTCIKSLKPKVSKIKLRSQGRVDENSPWAKARLGWATQLLIKLGLLEEDPTKDYYTKSKLESLEISQIVFWDETHTKCVIGAGAGRDFVFVFPRDSNGNLNPDGGTYTDTKFNRLKVKYEKEVRLCLGCAAVQINGQDEYVGKRCVPFDYSGKTILSISDYKSKCQAEIQRVRALKGEVPPWYLKTRVKDKCYRNDTVRIGLKRVGKVLQEQFQMINIFTIQDLIETEGSFADRLNPCPPGCKWREDQLQSWYKQAKENLVEGDGKEVVDHRKAENPYESRYGQGWEEELRKVLHRNGSVSVAHLVDHIVHESAQTMKGTKHDNDWRFYHDALTLMTSADLIDYMKAKGIYHRWILPEQGLFEDDTALRNYRGRPPGDSPELMPWDNNLNQDAHVSVERHVGITSVYEKGDPRKFSKSTPNEGARAYKRVLHPTEGVAPTPKRIVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYN3</accession>
    <name>A0AAD2CYN3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYN3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1942410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="104" mass="11564" checksum="50FFFFBEA66866A7" modified="2024-05-29" version="1">MKTLSIRIYGVDAPELQKRNAYPLSQPFAEEAKQLTSDLVIGRKKDVSIELTKRGLATLYTGGGAEYDGNRALLESLEGKAKKSRVGVWSNNNYVSPAEFKRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZX1</accession>
    <name>A0AAD2CZX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001262">
        <property type="protein sequence ID" value="CAJ1944864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="347" mass="39938" checksum="BCAA9A8A37A0DF39" modified="2024-05-29" version="1" fragment="single">MKKLEYPMALTTLDAQQWTDIMSPVLQVCLPKAGVCRNFPRDVIFAPLSYHKAQMVAKAKDWTDGKAKDWAEQLRPNLLHKYDVLPLIKSTIMKKLEYPMALTTLDAQQRTDIMSLVLQVCLPKAGVCHNFPRDVVFAPLSYQGLGLPHPFGCQVFKHLEMLLQHMANRTKTGDYMEANIQAHQLETGTSFGLLQQVYTNTAILASDTWMKRVWHELEGLDIYVAYDSPALSLRCTDDSLLMDLFINLEVEQEELLWLNWCRMFLQVCTVSDIVTADGSFIRRSAWNGLRDECCRSPYQWPRTVCTTRQHWDLWQTTLSRALLASNGPHHPLQQPLGPWTDRLEDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBV5</accession>
    <name>A0AAD2FBV5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000067">
        <property type="protein sequence ID" value="CAJ1928932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBV5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="18365" checksum="40F507E8A3547B44" modified="2024-05-29" version="1">MKALSYIRKRIGHHHDLFDGPGEPLPKGKQTEPKIKWRHSRARVLLYDDIERGVLQFDDEDQPMISLKDIYAMHPEYADYLFVNFERRLIALKDLFDELIRRADDDIAALENYMANHEISEVNWLGMIQWQGSEAQEYVIEDIDEDAHLESLQSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBX3</accession>
    <name>A0AAD2FBX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1893376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="2">
        <location>
            <begin position="486"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1893376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1551" mass="171573" checksum="7932D8BC4DF2367B" modified="2024-05-29" version="1">METYPGEILVGVFPLVFCVDATFDNAVGTPKGSSTKPPQSRSQFDRFLDAMASSLMDDSVGDHPLGSTGSATASKDVLNALLRNQSADDSDDDEALLSHTVPRSASRDDTSFKSSDSIGTTSKRFQLGRKKRNKSSLEPPLHQHDLDVSYAQALQNGQGFFQRARIMSISARHGFPPSKDATGDNNRVHQFYIGKNFNTMRLVNTMRGKPVDGILPSGWVEKHAHALPSVILVVVQVTCDQTQFTHDENLMNTLENLRYSLAPKRQCPVHIVGLVQEGVTNVLAEQWSANVSKKVQNGETIMLLHNRDLQQDAPPSIALQYLHSFTRQASYQYYSRQASRIKQKLAKLGPSRFSPILLPLSIRYCFKIALFHEFQWQEQKSIKFMLEAYRNADLYYRYLLHRKQHKQRTGEDLFQKQQQASSAAPPSLMDKVSMSQDSMSTGGGDLEMEGIELALESGITQVRRELTEEEINFLKSYPPPEDMLHQCRKIADWINFKILQSGLTSHVEGGLLAVAKQWQKHSAAFCSPRRSFVSVSLGGPGAWMDWAYVAHQRMVVSQLLERHPPKAIDGTNREMDEILFRCSPWRTYEATAEAILRLGAEIRLIQEKGELFEENVPQDSMRQKFVGGLDTDGHLPTLEEESKINHREVALACIERALSLLQRQVNSSPNLTWKRSAARLEYLAGGTLLGLGRHQEAIPHLTTAATLCDGWPGLEVTIRRMLIRCYEQHIPSQGDDEKKLASALLDTYFNAQMTNADLRKALVRYSELSGGGSVEWYRDCNDEADSTLPFSFFLSFPSITHAFAGDKVKARLMLKSNLDYAVQVDSVTLKSLAGSVSIPSTDLQCAKNADQGSGRGIIMQAKAEILLSTEIQLPKDINDIAIDETGNGGEKEGSAGKGSFSKTARPRTGGISSGAGARLVEEDVNADKKGGQSSGQWSLRCLGGRPLRCDGLKIDFYPVQSATGDGKNTVVELTIEKKYARTDANIKRTPFEEDNYLASAWRRPKLAPMAWGPRCLRVLSPMADMVITNLTEQKTNGKAMEGAVNRVLLKFKAGEFERCMGVKVKISCSSFLVSPEGKVRRIVGSQEAGSDESCLSKENPNVRTPTLVKKQEGLPPQPADVGYTLPEGWGGNESSDFVSIAPQLNGGESAFTYFDLYRPLPPISRAQFVLSEGSDGDEFSFDQDMCQTDVDVTVSYRQERPSQKGNQPLRRRGRRKPDEVQASEEELTEVEDDIVTLEYNARVQWAAPISAVFKLGLNDSHPCGNRHPSNLLPDPNATSPRHHESSDIVALHGERVGARCTLEAVAADDSLVPNIEEVRFKNDEGEHPCEFKLLTGKDESGLLYKGEDGDSCRELLPGTTFAFSWTALAEVNPRYQQIPTSSSLGVISVGWNPAPLTLPDDYVTSDSSEPISEHGPLPLKTPPTCRFIGPPCYIEKAPFAVKMNRLQSSPKVGSPFSISYQIKNMTPQHQALKVSFKGSIADREAQGYMLSGLVDGTVALGAFEIHNLCYTVIATRAGAIQMPRVCVSSDRFGTWVIKETLTDRKELFIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCG6</accession>
    <name>A0AAD2FCG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1921827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1921827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="155" mass="17411" checksum="AA47F48C9EB4478E" modified="2024-05-29" version="1">MAPNGKQNGNIFDTAIDTAKAGIENVREKVNEATKSEEEKEAENKTTTEWIGDKITGVRETLSKTEEPKDIEPTTTDKLADKITGVREDVREKVHEATKTEEQKEAEKSITEKIGDKISDVREKVKEATKSEEQKESEKSTSESDDVPEKFIQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FD43</accession>
    <name>A0AAD2FD43_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000050">
        <property type="protein sequence ID" value="CAJ1928526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="869"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1928526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1601" mass="181811" checksum="28557DC03BBCABAE" modified="2024-05-29" version="1" fragment="single">STDTAAQNKFKDDIFEAVLATGFLCNCNQTGRAPLMLDLQMNYCRKISFYERLSTFLYFYHPPSKMAAAIPVFTIYDAMILCQIPDTGNFQGQTDAQRMAEELFDNDFSTAMTKSIKQVNMDLATLASLTAMQGRIVSRPRAQDRIRAFVQWVRDEIRMGRNPAQHPFPAGDTSTLLQRLSFHQKYVKDSKTLIDNTVPPKWSKEQQWKQWVKLLRDHLRAYIGVNGIPLVYVVRENAAQDPTPQDDFLDEYINMALLVGTAFIVDNKQVLALLNKFIMGCSEAEMVIQALNTTTDGRAAFFALKAFYEGEGIFAHDVMAAENIIATLFYAGEKRPAMYWQKFEQILNNAYATMHHEYGRVMYTDVMKLRSLQQRIKADFLSQTKAAIEANMHAIPMTMTYDQAMRMYRSKVAEKFPPASVAAVARGRHVRENNRNTRGGGRGGGRGRGGRNQRNNSGDNRRYNGNRQQHPDERNITLSDGKVIKYHPSYNFSCEHLDLMTQNQRNTMTAERTAYRNRHKNNLDNASTNENTRNIAALTSLIGDLTDRLTVPTEITQATAATQISQVITGTNGRSIIGGRLQQAQQRQNGGNGTTQRLGVQEPVAGTYANNEMDTNADTCCLGSNFIITAYTQRSADVYAYDSSLPPTHVPIVSGATAYDCPETGSTFILIINEALYYGNKLDHSLFNPNQIRSYGTPLWDNPYDDMHEIGIEATDLFIPLLSRGTKLLFGTGAPTKQELETCHHIELTSKVPWERSTVQLGKLSTQRNTPFEDPRSNESEMRSLDPVQHNLQQWRVVQQINATADRFQDVPVPSFVSTERHSKVTAENLSERLGISIGRARATLNATLQRGTRSAIMPLARRYRADRMFERPRLKGKFSTDTAYFKRTSLRGNIASQVYFHKCGFYSCHHLQKVNDAQVGPTLNKFISKYGIPEHLTMDGAPVQIGRKTTFMDTIRRCNIDHHISKPYTPKENPAEGGIRELKRRYYRLIIKHGIPERLWDFVLDYVVDTMNVTVNYSKYSDGRVPLEIITGITPEITEYLDFTIYGWVFFRSDGGLGVNHIGRWLGVSHRVGPMMTYWVLPKSGIPISVDTVQMVTNAEQQTDSVKQQMQRWTADVSKIVDAKSTYINWGKEDIPHQMMFDFDDEDDEFMRNFGMLINPETLEDGDFEGTEEAADDLDAQDYTNMEIGLRRGAEGELQRAKVKRRIVDENGRPIGVASSNQLLDTRQYEVEYADGGTEIFAANILAENLLAQVDEHGHKHRLMEEILDHRKTAKAITKSAGSMLLPSGRTRKRQTTAGWELYVIWKDGSSNWVTLKDMKASFPLEVADYAKLKAIEDEPAFAWWVPHVHKKRDRFISKVKSKYWERTHKYGIRIPKSVKEAIQIDRENGDTLWQDAIKMEMKNNRVAFEEFGGDIKKLIGYKHITGHMVFDVKLGENFRRKARYCADGHKTEAPAALTYSTVVARDSVRILLTIAALNGLDVQCADIQNAFLTAPNLEKCYMIAGPEFGDEEGKTFIVRRALYGLKSAALAFRSHLAETLENLGFYSSYANPDVWMQAAIKPDGEEYYEYILCYVDDILCMSENAKDVMEQISYKFKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEX3</accession>
    <name>A0AAD2FEX3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000302">
        <property type="protein sequence ID" value="CAJ1933780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="308" mass="34499" checksum="AD665976BEBB03D4" modified="2024-05-29" version="1">MPGGESTRRSRRTNLGQPPRRLGEEEETLEQDSNRTVRFRDDNLEEIIDNRTAQVEMNQGQGAQQGGSNSLTEELLYNALVLAYDSVDQDQFKAFMGVKDNSAIQPHEDLMSEADAKFLDLDEKKVWNVPSQSQQIMSLTTLISKAEKKTIDVQRQLDKSKQSRKEKSKRKPSPADEAADSGKRQRQTDFDRWMVTKPKKGEETKVVQKKGPNGQVKGWNWCDKHKKMVLAIGRDGRPHNSDTCALSKTQSNSNPKRAKKQLRVNALKAALALEDDSASDNATSNSDDTGEFPTNDDGSNENDSDNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF36</accession>
    <name>A0AAD2FF36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS3705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF35">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042040680" description="EGF-like domain-containing protein" evidence="7">
        <location>
            <begin position="16"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1934336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="340" mass="37390" checksum="DA615E3206B42E21" modified="2024-05-29" version="1">MKHLLLLLLPAVNLAYNWDCNLFCFNGGECRHGKGKFGSYGNVDAENPWESKDHVEGMYCSCPSGSTGLQCEISLKGCRTTENNFQHNCDNGMECKLDKNGEGHSFYHCECDDDTVFENEYVEKYCAHISTVFCGHNKNDDTFSSSQFCVNGGKCLPDDTNGTKHPGCDCPDNWHGKHCSEKAPPGLLEKGKEVVFDLASAKNLFLLVVICVFAIGICAFLVNRCGIKMPKIRRRRKTKKQLAEARKAPGLLRTNLKLRSEAKKQAKESSGKKSGRRVGGKRVGGRPSASAPAEPQVDEESEALNQEPMVEQNVRFSDYGKSAGLTSYSDGPEAAEGEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFH5</accession>
    <name>A0AAD2FFH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000568">
        <property type="protein sequence ID" value="CAJ1936845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042036947" evidence="1">
        <location>
            <begin position="23"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="502" mass="55410" checksum="DA9E2C0408B58CCF" modified="2024-05-29" version="1">MTFMTNAAKSVILALIATPLQSTAFHPLYQRHTWSLSRVKTFPDGDDNGEMFNDFEDIFIGEQQDDSLLPSETKSLQTRLDILVNQEHEDEVRIAGNWKNGRWSVRGCSLDPGNEDERIFVSSLCPIDDDPNTVLVGRTDGSICWLKLGNEYIARFVTKLSAIEGKNETIRVSGQLRREDTQNEISSDSSQASNQFEVVGQVMAHGGGISQMLIQDELLLCATYSGTLEYWILSGDEPMSQESKILCQAPSSVVSICVQAVNGKRVLVCTCEDGDVLTWDIEAQFAPLQSRKLSAVVTPGDTILSFYSDETYSYFGTSQGRLLVYNTRDILASTFDINAIKRFSPFSGGSAGVSAIVSSQQSGFASESQASMTLVLGSTNGKIKQYAMMPQKIGLEHWPRLESQSIPGKCHLFESPSEERVRALRFIPGAILAASSNQLTLWDPENGKALFEMLGLDFESTEASLVLLDSNSVLITNGMKHLVCLHDFSEQELDLDENFEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFN5</accession>
    <name>A0AAD2FFN5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFN5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="498" mass="56894" checksum="BE64BE81039CF908" modified="2024-05-29" version="1">MTCSFLLGGQLGILSNLLGQSAEEMLRLYEYSQGTYNRRTMEVETNDPGVVTIRSFTLDDPPPLKLRRDVGVPRLQDTAGFWKRVNKESPEKVRRRIENVKHLTTIQKSLLLEQYDQYQATANQESASNKDSVRNQGKESILPHSKPDADLVGNRNVTIQPLFSWEKIAIETRACQTPHRGIPKHCCPGSYSAGGRLLFFEGVCNSTEPYEIVQEYAMEYLKKPYLARDKDDECDACSIVETLMELNLTLSFVGDSLTRQSNAGLECELLRRGYMVRSKKSSVTKREGCSWRDCIGEWMVFTVTNPTNMKTATFNHFGMYRPDPSNLDLKEIILPHSDIVIFDHGLHWKPKEQARFAEAMTRYLQGFQDANLTMLAWRETSAQHIDSDGGHYGLEAKSKNCVPIHPDHQAGYRMPIMQQAAENAGLQWRSLAEPDFSAQDKETNEIVFLPFRDYTVPLHYLHPNECTHYCHTPYLWLPLWRSLRIALDRAVAPASHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG36</accession>
    <name>A0AAD2FG36_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000678">
        <property type="protein sequence ID" value="CAJ1938172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="199" mass="22359" checksum="366610B5BA9C48E8" modified="2024-05-29" version="1">MTKEGEHPFAKQKLTDALNASVTSPTGALQCHDDEAQNAQKPKAMGVQSHVRIPPTKKTKTWLSPAKRRKKVNPRIAHFKQNQRAVDDISKKAFNPLDDCVICHAKEIDLRVPHRPHDVRCPGLLKNSQGERKYEKDLRNYFNAPMENPEKEEELTGGGTPSVQLYYSGPTMTRRRKALAAGKLPAQAQATTVQKWESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGD5</accession>
    <name>A0AAD2FGD5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
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            <begin position="345"/>
            <end position="359"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAJ1936597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="527" mass="57926" checksum="81A36350813CBCF1" modified="2024-05-29" version="1">MPSTHIRPKIRKTNAKATKSTSTKPPPANDDDSVDALERKMGSWIGLSSEDDKATSSSIEPDVESTTSTITTSKAATTIVSTSSSEPAAVPPDATQTQTIQATSSTTKPLGILKKPKYSSTGTTDSQSQVTKGDKTNNLRNNKKAATGVVCEPFVVERDPFQKPPMRKTRPKDNTANYATIEGYEPSQSTPQSAVSFAPGDGASTDQEMQGKGSTQPIETSSPANTTTNAEEEEMEEPIVLSSLEELFEAAGNELPADRTKVTPDAKLVEADLAFSVMTQEQYGEKVTEMKRELAQEQQDMYRMFMGNEDVFDDGDSTSGREESDEDSEGEEEFANFLMEQEMGDADGDDYYQDDDEEGNANNAHTSTPRAFALIWGALARWWTPEAVEWMARLERPSSTETPLYGNNWSPQVDRSDIGASRCAGLMAMVKMYLPSSMHELGFQQELQRTAESRIADWLRTFDYSSEAPKLPVKMWKAISCMLLDMVLVESRKTVVEKLPPSVAAVGMSLEEYKYLTRSAVQAFQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAD2FGM7_9STRA</name>
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        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5598</name>
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        <name type="scientific">Cylindrotheca closterium</name>
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            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CAJ1937299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="PH-protein kinase domain containing protein"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="PH_domain"/>
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        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="120"/>
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    </feature>
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    </feature>
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        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
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    </evidence>
    <sequence length="174" mass="20273" checksum="3F6B5F7C4AA7C43C" modified="2024-05-29" version="1">MARPPYVDPNTNIIYDCDNPEYQGYLTKQSMWLKDWRRRYVMLKGSKLFFCKNEYGAPHGMIDLASCTTVKSADLKSKKRHSFEISTPETTFLLYADTEQEKDDWIGRVGKAIVRCSSTYHGQNNKQQQQQQRQQQPGPYGQMQGQHFGGMDDDSDDDDIYYEDPNNPNPYFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAD2FGT3_9STRA</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CYCCA115_LOCUS2007</name>
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    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
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                <person name="Bilcke G."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
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    <sequence length="208" mass="23692" checksum="9968B74BA2D1F189" modified="2024-05-29" version="1">MTKDMRPRPAPAADSRIRDNLIFKLGVVKSDQKPAVRSEKSVLGKQEFASEPLKSRLDEEDIIESPGWNLSALFSKSPSRTPSVTDLASLSSSHTTSDSVSETSSAANKRLTFNETVTVCSIPNHDAYSKRIKEQLWNTPEEIMANATRNSIEFAAEGWDWRNTLEDENMYRCVGSNEKIHPVHVENYEQQHQQQQEQKEEQQQEREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGT4</accession>
    <name>A0AAD2FGT4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Cylindrotheca closterium</name>
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            <taxon>Bacillariophycidae</taxon>
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                <person name="Bilcke G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3663"/>
            <end position="3693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3794"/>
            <end position="3809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3811"/>
            <end position="3820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3954"/>
            <end position="3973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="4130" mass="453121" checksum="8A05AE7F86BAFE72" modified="2024-05-29" version="1">[encoded data, 4130 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH72</accession>
    <name>A0AAD2FH72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS2424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000158">
        <property type="protein sequence ID" value="CAJ1931520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH72"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1931520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47796" checksum="BEB40AB5F90D7410" modified="2024-05-29" version="1">MQEARPFFLLDWLDDLMVNQDAFQIAELLKTPSKLPQRQHLQSHHQLGSYSSHHQMISMMETDDFNSSERDQQQIMLRSISSPAVSSHLSSSAEAAAVAIPGTPTANTFRKSCIDNTHMNGDSHGILPTRLFHQHNTAAATAMGQKLETTIQLSQLTSSKSSNSLLPNNKVKSKPTAPPGIFKKRSMALGNGWNAKGLTKAKQGRWEAALACWDNALEIRLQISDASCRKDQLEVANTWNNRGIALGKLGQYHNAIQALGEAYQIRKTLLDQGHPQVVSTLHNIANVHQQQGDLTTALQVFGTAKSLLVQSLVASSPTNGNTNTDPMLLARICTAIGHIYYQAQQWIDSRDAYQDALNVLLKFDSSSSASTDQQREIYELQRDIQELNGKIPITFANHGMGSMATMGGGGGVGSSFYHGHHGHCTSTQQSPQPQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJJ2</accession>
    <name>A0AAD2FJJ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041920323" evidence="3">
        <location>
            <begin position="19"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="795"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="962"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1124"/>
        </location>
    </feature>
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            <begin position="1158"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1190"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1267"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1291"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1357"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1413"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1496"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1529"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1543"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1602"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1628"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1663"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1711"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1753"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1774"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1792"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1855"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1895"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1921"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1958"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1994"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2040"/>
            <end position="2051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2051" mass="211260" checksum="A383ECD6833D15B6" modified="2024-05-29" version="1">MKILRLLSIACLVDEGLAAFLPFRLHINDRRSSFGQKQSNLQDRDPSSYRIREGLALSEQTNNLNEEVEWNDNEIIDTDASMAELELALAESQRKRAALEDELMASMAESVLNRTPQMALAELELAQANKNLLSQDLIKATTGLLGPIGGIVGVSAAGVVAGRNFLQKRQAKIEDMERRAYQSRLDAALQLEKISVQSAAQKAAAVTGIAALGVTLSGTLDEFSLPSLGGNSMPTISIKNEQQVAQKKLVEPKPELPYLEENIRNAELEVEAKEKAVLEATQKSQRAAGEAATLATDELPSLKENVKKAELEVQAKEKAILEATQKSQRAVGEAATLATAELPSLEQNIKKAELEVQAKEKAVLEATQKSQRLEQMLKTEEQASLTLQAQLKAAEEAAKMATARLSSAELAAKEAEARALAAERKATTSPAPITNIDMEKKEDNAFATRKKEEAESLDLKRRVAEGMLRPTSKATSPFSSKLATSTIATPTAGVAATAPSSASDALSKVTNNPAVLAFIGGGVAAAAGVATAIGAAKNKEDNDKQKKGDPVRATMKISTSKPKAKAKKSDELPFNIPPPPKEISSPSKVGKRGDDATKSSFASSKPASVEETKPHKSGTESGSSPSTTSKGPKGSPGPKTPKFISSYDGPADEDDLKSLSSAFNPGVDILKDNAFQTGPGASKFSKFRASDTSQFGPGSGAPKGSSPFQTDPGASKFASKFGASDKSPFGPGAGASKGSSPFQTDPGASKFASKFGSGDRSPFGPGAGASKGSSRFQTDPGASKFASKFGAGDRSPFGPGAGASKGSSPFQTDPGASKFPSSRKGASSVGASSKSSSKEESLFFTGPSTRSPLGPGFSAGPGVPKGFVTGPGPVNGQSNGVDSAESPRAGTVDTGGSQGFLSSSPPNGLDRGAPKGFPSSYSNETNGGNGGVKGIGRDPVAPLDSPGASPFETSGKGLPKRGSSFFTGTTTGSPIGPGVAPKGFGAGSGVPKGFPRPVNGPSSDLDTRSKAAENVAPDSFESGGLEAPKGFSSLSNRFASPVNGRNNEVNASAKEPEAGTVSSNGFGSGGPGVPNGFPNPANGQSSDLGAGSKGTGAGAGTVAPKGFWRPGGSQGSPISANGQSGDIGASPKAAEAGTVAPKPFDGGPAKPKDDAGQVNGQSNDTTASMKESKAGTVSPNDFKSGGPGVPNGFPNPANGQSRDLGAGSKGTGAGAGTVAPKGFWRPGGAKGSDSKGDSTGLGATKDGVSGSASANEFASPKTGLPFGSPGSAAKSSSGTSEVKGTSAFEISKSTAPSDFGSSSASFRPLSGGKSPAETNNSYTGARKREFKLFPKSGSSTVKKGAPASFDPFPSSRPDTPGGPTFPTKTGSPAGSSNIAGKPDGRKTFTSFTGKDGAEVITTRPFGNGPGKSLSGQSNSSGKKSFQPPKTGLKSPFQSSEGVAKKDFKPYSPKGMTNEVEKKSFKPYSRPAEAMTSEADLPAEFNPTFPPKEGVSSKGTDGASVSGSNLGFQVQDIPQSPATSVDLPASSSSYLSGMQGSTSKNQGVKSSYSPFGPKKKTEPSKSSTYSPLGQWTPGSSKADASANLGAPSLEGSKTDDAATEASATWASASVSGESSIAPSKAWETSKLNNDLPTASMESTPLPISLQENEQGLAQPGEASNGEQNTEEPQGSIWDTLSATVSSFTGRSTYSSKQATTASDTAEFPASKVRSSYSPFGPRSYSQGTPRAPFGVANTVDPTRNIVEQKRAIQGATSGNSPVKTSYAPFEEKESSYSPFGSASVPNPSEPQVVPSQGNANVNSPFGSWSPPVPTSSETTTNESGFSPFAEWLKNEPQPGQPATSTNASPVAAGANPVSTPQAPSENMASQNTDNPVYFSPNSPGAFSKQPPGRSYQPDQNGNQSGSVADFRRPRSTNSYGNRRVEDFRRLDEEATEPTSRYVNRAVDPTQSYRRPDPYLNSSSSNVPTRKQQYLNQERTMQQATGRQADPFYSSPYGTRPTTKSDQIDPNTETAAQRGRSGPKDSKPSNNWFDDGRGGKGSLNQDWQWNSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJS8</accession>
    <name>A0AAD2FJS8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001311">
        <property type="protein sequence ID" value="CAJ1945023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042289126" evidence="2">
        <location>
            <begin position="30"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="392" mass="42757" checksum="E46F12DF9F29C6B7" modified="2024-05-29" version="1" fragment="single">MTRQPSLHHLFLSCLSMYLLLLLPKNSLAFSTAVAGGGGGGGHLSSSWTSRPHHASSSWSSSSTTTTTQLQFVPSSEMQQQGGEEEEEDQQTKNHDHAHDPSSCWTMAQDWELIDQLPKFTVGEGEHCRTFWTQMAASTPLLATKSPDELLERCQYLFLQQQQQQQQEEEDDENENGNDATTATTTTSTSPAAINNHSTTTATTTISGLRRPIVFGPSPPVLSQWSILDWNQHHHHRKQQGSSKVVGQLVDDSNNGARTIWMHYHCIGRLDGDPLLPDATTSSPSVFQLVSGGYLEAIGGRIYELGEAREQPTAAVLPTSRTTTTATASSSSSSSSSSSSSFMEDHHPSSSSSSSYFGMLEAMDARRKAGQMTTELDLLTKQGESLDWLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK62</accession>
    <name>A0AAD2FK62_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000583">
        <property type="protein sequence ID" value="CAJ1936974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="118" mass="13526" checksum="B9C5E6A6F680DEF4" modified="2024-05-29" version="1">MKFFDKKRDLETFQDGDQIAGVDDTEQGYLEEAFDQDYEPEDEDERDFNLHGQFNDIDDSKREELLADADNSVNDMPEITVRFSGDDNYESDDDLGDEGDEKEEPIVANLDGSPSRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKJ2</accession>
    <name>A0AAD2FKJ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041935390" description="VWFD domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="94517" checksum="C738CADA3B1E1558" modified="2024-05-29" version="1">MRSFLPLLASLLLGATLSSALDEDSQQQYLRTNSIVEGGYVGPPRLPADFIPSDVDVKVTVLEQETIEARKLQTCTPTVLVQQSCYSTSDVKIIAEVKICSGVPDEWLGIFHPTDTGFASALNFQYTCGGQACGGATGPPDFFQSPTTYLYEFNAQTTGSEGWPLPVDSGYRLWYHSKSGSYGSNSFSVGNCGGPVVAPPTAPPPTAPPPTAPSTPACSHSVSVNQNCWGLGQTITATISTCGNNVEWVGIWDAGTGSFRASYNWQYLCGNQGCNSRISAGTRTYSFSSATAGSVNWPLPAGRTYQLYFHSTFGTIASQTFQVTSGTSCSSSPTAPTAPSSPTAPTAASSAPATTAGGGSTAPASAPIGIQYAPASATDCAAIQSGNIVVGQSAMPSQTFYFVFALGVYGPALDSATVASIVKTAFQNLISTGVVNCSHRRKLMQYRQQQHHKNRRHKNRHHHHHHRQLESRLPDGRRRLELVENVIGNVMFHLICNVHPECQPGMTGCFECTASVEVYKKGPAADTDIEALLTSYLEDPNLLVDSGLEDQDFAFLRAEEITFITTDPTSGPTSLPTSGPTSAPSPVPTSGPTIGPTTSLPGIPDGGTGDGGDDEPKEDPGKAGSNGDPHFKSWAGDHFEFHGQCDLVLAKDAKFADGLGLHVQIRTKLVRYWSYIKSAAIQVGDDILEVQGSADTEDIGSAHFWYNLEYQGKMETVGGFPVSVHIDNGPRRKHIFEIDLSSKYPGQKIMIDHTMKEFVKVDFVGPSIQAFGNTVGMLGDFKTGSKFARDQITVIADFNELGNEWQVLPSDDMLFHDVSAPQFPERCLLPEDPQGQRRHLLEGSISGEQAEAACAQLKDPLSIKDCVYDILATQDLDMVGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM48</accession>
    <name>A0AAD2FM48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001236">
        <property type="protein sequence ID" value="CAJ1944709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM48"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="114"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="317" mass="36743" checksum="5038107BCF505D96" modified="2024-05-29" version="1">MKYKTHLQNHTNWTIALDRGYLDIFNDAFILDAKYEATTGAEVASKQVHLTKQDQLATALENTRELFDGNLGHYKQEKIHLEAEDGALPIHSKAYSVPVKHQHSFLKELWHLESINILKQCGPTEWATPTFIIPKKDGRVQWISDLCKLNKVLKQKVYPLPLIDEVVSRCADHKFFTKLDLTIMYYSFELDDESKELCMVVTPYGKYQYQQMAMELKPAPDVAQCYIEKTLHGLKEQDVEVYINDVGLFSNSYEEHMQFIKTVVKRLQEAGFKIKPLKCEWCVQETNFLGHWLTPEGVIPCKKKVDAILKMNAPRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FND8</accession>
    <name>A0AAD2FND8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001723">
        <property type="protein sequence ID" value="CAJ1947016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FND8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="315"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="440" mass="48699" checksum="9508C2DF49F675AD" modified="2024-05-29" version="1">MSKKHASSVPLCLNPDTGAITTQFHIVFDPTFLTVATKVDDLPDSGSEAWSQLFGDSVYQNVLDDPEDPLHPPDPTDNPPPPLTARVREQTEVHNPPTPLDVPTPPPARKPQPTPTSKPAPLPSATRTSRRSNKAQLPKRFGYDGHGPAGYNAPIKSQSPETNNFYTYFSAYFNSLNIEVEHSHNCSFVPSSNKARATKDPDVFTYNEAVNGPNSEKWTAAAKKEIEELEGQLTWIEVPMLKAKTKIIPGTWVFRVKRNPSGEMTKFKARYCVRGDLEEMDVGKNTFAPTVAWSTVRLFLVLCLILGWATVPGKGTCLQLNKSLYGTKAAPALWNKTAVEGFTKCGFKQSDFDPCLLYKKGMMVVLYVDDAGIGAKDPADIDKLIEELRELQFELKNEGDFNEFLGIKFDKRKDGSVELTQTGLIDKVLEAAGMTDYNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNM6</accession>
    <name>A0AAD2FNM6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001727">
        <property type="protein sequence ID" value="CAJ1947448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="10701" checksum="BE1CC4BB0B94CB62" modified="2024-05-29" version="1">MPDKKAPSTESTHNWRHSTVHLLLRVWSCLQCHRSNDDKYLRAVALSVEVDRPPTNAPGLLRFSKGNIPTSLMKLLGRWRSVRAFDALLDQCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP61</accession>
    <name>A0AAD2FP61_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1948007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042164407" evidence="2">
        <location>
            <begin position="17"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="663" mass="68742" checksum="5063FEDC4C0795AA" modified="2024-05-29" version="1">MRSLTISAFFLGLANAQRCPGICINDGEQLLNPTEPIFLNSGTQFCATLNDISRQIVNNAVQCEDSAIQAIALGCECGVPPTPTLAPSPAPVVPDLPTLAPVVPGQEPCLGICPGGTLLNPNRIITIPGQTADFCFVIDGQLQEIVGNPTQCNTLSTSARISGCQCEGVPTATPSMNPTRTRSPTPRPSVNPTGTPTGSAAPTRSASPTKVPTTPDPTGSPTTPKPTAAPGPCSGVCYDASLTVADPDFIIVVPNANGNGIITETCGEADARYRQIVAPGGVCETFSRSAQNNGCSCVAPVECPGICNSGLVTPKSGQQIVTPDLLVNIDGRQDTCANWDARWDGTTSPVLCESVPSKISQALSAGCKCDVPVDCEGLCPGEQVTTPNVVVSLSNGVEAPCSQLDAEFDATIDPGRCNEYTPFKAEMLNNGCRCGTPIDCDGLCPALNEELLTPDLLVDLPAGTSATCSSLDLLARQLIDEGLCTDSINEALAAGCRCGEPKKCDGICPNKDRKLFDKKFEITVPWTGELEECDKVEKEMKDTIIDEIVCLERREGAIQAGCQCGETTESPSMMPSISAAPSRAASSNPTGVPTGTPPTVAPNTPLQNEPTVTGGEPTIDGGDEPTTNDRSPGELNSASGNNKQYLMMTVVTMVAAVGVALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPV6</accession>
    <name>A0AAD2FPV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001756">
        <property type="protein sequence ID" value="CAJ1948802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="128" mass="13562" checksum="DFFB2D8813CB2158" modified="2024-05-29" version="1">MANTDAQVATMTAALTQVGVQFLAQLKARQTAAATAAAAAAPPAPPARTAVYNLHDSGQPVDLCSRSGAAAADKASAKLPIEITGDKAEIMIWIQALQRHLHGCCRTHGHSIFWWQEPPNRLSLHSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS60</accession>
    <name>A0AAD2FS60_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="167" mass="18514" checksum="CF55849008C0C2F4" modified="2024-05-29" version="1">MRGASAAFRTYLTMADRHKSLPPSLAESVLSKTNAIVKEGFAFLKQVVEIPKVLFRPNRKTPANLLPVLLRKRATLVRTKPNGHGSHLMLDFGSFSMTIYFSPLLLTLRANEEEDGDENDGDNEKTSETARTVPGFSERAPRLGMCLLETSSPWFGTSTATQRFAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FST1</accession>
    <name>A0AAD2FST1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001802">
        <property type="protein sequence ID" value="CAJ1952165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FST1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052160">
        <property type="entry name" value="Gypsy_RT_Integrase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47266">
        <property type="entry name" value="ENDONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="51"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="666" mass="76244" checksum="4DA54F2EDEB32F44" modified="2024-05-29" version="1">MAGHVGFHKTYYRIAARFWWPGMAKDIREAVLGCGHCNAAYASSHKNQKILQQTPIEEPFDVYCMDVWSPGSTKNATKLSTTLTKTLTNKGVVTYVCNMTVAFISSMNSGNMARIAFLQFFTVRGLPRLILIDEGSENKDQFTALCDTIGIAYHTVSPENHDGILCERFHKYLNKVQQIGAADMNTYEEWAMNTLFGTYAWNAAPVDDTDIQRAFAAVARHFKFPLDNAAAALSISEARQKNRTRHQQLPGQNTLEHIETMFPLFWRQKELLKLLNEEQREHHRMLKNQTRTRRKFDIGDIVMVRKQVQSNASAGIPAKLVLRTKGPYRFIEKASEDSYRLQKIPGTSTMLKKRGSTPIKESAFRMHKIPSTTILHKGVDTPDTRLANMRSLLAHSPLEMNLGLVDFGKYATTPTDTENAFEPIKNIWDEEVDPMEDSSDEEEDNTPTPSILDAIQRTQPRPINRDIPPTDTEGANQTRQVHTTETITEELNLRSLYERTTQSKDKLYVIAHQDNTSGWNNWYVIQINMEETNEKLARTKGQYHCKEWYIPKLTTTKQGSPMTSPFWPLIKEFTDETTYGPTVPIRHSKVDQVLNKSPHKYAWFQKEVNIVEDGVYGPFDFERDYKIPDVVWEKVREAATQMKLKVANITPKSTPPGRAHKRARHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU08</accession>
    <name>A0AAD2FU08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS13870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001817">
        <property type="protein sequence ID" value="CAJ1953098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="394"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1953098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="616" mass="70431" checksum="06909D84A44020F0" modified="2024-05-29" version="1">MVAEAVDSMASAVDAPNLVVFFFSQDKTIKAEANHSNKTVKTTMLSRTTIKKLKALLRKVAFLNGTKTECLMVECQVPSSTSIRNNIINLKKISTLEKFDDADGPMTKDEKEFILNDSLLHIPTPKQDVNSMEDLMRKKRLSPTSLVIWKTIGGIESGKVLQVLFDSGGSHTMINARAIPKDAKVQSIQNAKKCTTVAGDFVSDKCVKLRDGVFPKFDKHRRIAGVNGVKPNVFDSPTFPHDVIIGRNLLHKMGLDIQFSNGQVKWIYKFIPMKAPDHWQNYTNYSMALDRDVLDIYDDDDDADDAFIMDAKYEATSGAEVADKQKHLTEDQRKLLAQALKNTDKIFDGQLGHYKHEKVHLELIENAQPVFSKAYSVPKQHEPAFLKELKHLQEIEVLERTGPSEWASPTFIIPKKDGRVRWISDLQQLNKNVKRKVYPLPLIDDIVARRSGYKYFTKLDFTMMYYSFELDEPSKKLCTINTQYGLYQYNRMAMGLKPAPDFAQYYIKKTLRDLKEKGVEFYIDDVGLFSNSYEEQMALIQEVLQRLQAAGFKINPLKCEWCVQETDFLGHWLTPEGVKPWKKKIDAILKMSAPTNVTELRAFLGAVTFYRHMWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUE7</accession>
    <name>A0AAD2FUE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mRNA export factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1953443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38295" checksum="7C8D54B5E1BCD997" modified="2024-05-29" version="1">MSAFGTNTGTRVNSIAPQDCNVPQAGNDGISSLKWSPAANFLVSTNWDGGVRCWEVQEQGGQVRASPKAQVNHDSQSPALHCCFSPDGSTVFSGGADKAVRMWKLGENPPGGIAQQIGNHDAPVKAVGFLQPSSLVVSGGWDRKLKFWDMRTNNPVGTLDMPERVYDLDVRGNLMCVITANRRMMIYNVGTPQPTLVQNKESPLKFQSRCVSCFPDQTGFAIGGVEGRVGIQYVQKVGNKDHFAFKCHRKDNNAFSVNAIAFNNQYGTFATCGADGVVNFWDKDNKQRLKGFNPIQRSIPCAAFNAQGNLFAYASSYDWSKGSGYHTPGSPNEIYIHYTPENEIKPKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUK1</accession>
    <name>A0AAD2FUK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1953626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="205" mass="24321" checksum="0B0772B7067B288F" modified="2024-05-29" version="1">MGAYKYMEEIYRHKQSDALRFLSRVRAWEYRQRPNILTCNRPTRTDKAHRLGYKAKQGFVIVRAGVRRGGRKRQNHRGMVFGKPKHQGINQLKFERNLQSVAEEKAGRRYSNLRVLNSYWVNQDATMKYYEIIMVDPNHQKIRNDPRINWIVNSVHKHREMRGLTSAGRKGRGLRKSGHRANGIIGGSYRAAWLRRNTMKLKRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUR9</accession>
    <name>A0AAD2FUR9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="132" mass="15236" checksum="8B944E9ED85C6056" modified="2024-05-29" version="1">MRRPKLRNATRLDETHETIGFDGNQNHIPNRRRAGTDDSADTFTSASSSRQCLGDALKDCGDFHFDMSDRWKTALMEALDQPMFPDEDQVLPRHRRLRKGVTNFVKKRAQGLRRDSRRDVLDHQPVSPMAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUT5</accession>
    <name>A0AAD2FUT5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUT5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="103" mass="10879" checksum="DA905CCF64CC9CA3" modified="2024-05-29" version="1">MKQVFAVAESKTGVCMLFLIGLDESSEESIVFFKSDTFGQGKVITVTIVVSNEDEFGATNLALCSTCGGGQESEVMVSHADLALGAKGTRLLRSKTKKDGPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVC2</accession>
    <name>A0AAD2FVC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050994">
        <property type="entry name" value="At_inactive_RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF58">
        <property type="entry name" value="RECEPTOR PROTEIN KINASE-LIKE PROTEIN ZAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1000" mass="107036" checksum="B733C713B7B86BB4" modified="2024-05-29" version="1">MASDNDSSSSPMSYSDMYNDDTFTMVEEEDQTSRIGEKSPSRSNKSDVDFGFDDEDALDFGSAAYSVPYMQGGTDQPSVATSVTSVPSDQGRRPSSLLGGDDSSVASASPSVDSYGFSAVGSVAGGSVNPPPPSIMQNRGTATPTPYHKMAPPTSVIGGSLTSGTSNPYYESHDDDDDESVEMSLVTPEPSTPGRNNPFGKKTKNTESLLQDTVKIQFVPAPQRPKTTARQTSTTSYPDNPDDEFGVSVISSLQDDLSSVQNSSSVKYVPSPFAEAGTAPTSPLTPVFPDYQHKVLPTNAPMAPLPHGQKIDPSVPRPDSDEESGVPVNHHSEYPSQPFGAGNGQAVFTYNLTSSSSDEVSTAGQSEQEYRDEFLEKNQKKLGQSDGPVSVSSSVATEKLGGTRTNPFATSSDDAAKQDPETALNLKDPQPKKNKKSCCRKCLCIFIPLLLLILGGGGYYAYTKDFYGFDFFGLYESKDAAQQQTEGGNILENSQDVSNDDPQETDGGGIGFPNSPTSSSTTAPSVIMEPPADDGIDNGATNNSTNGDDILGNNSTNSNSTAGDDSLIGIIGTKQPHLTPVDTKAPTQSPISESLPTATPTIMAEATAAPTTQAESEIIIQYRTTIQSFLSTQQGISFDTTQSTMTVNALDRLMNDVVAAKFQEVEPADPFYEDIYRVTQRFALYCLGVALEEPAQEDFFTQFEVTKSWTPRSDAAPMYPLVFERLNAGETKSPDHCNWPGVICSTGDSPEIVSITWNQKGLDGTIPSEISLLKALTSIDLANNYIHGTVPSQLYEIPNLQKLVLNHNYLEGLLPAPTALTRLTHLDMGQNLLSGNLQSLLSAQGLEYLNLNKNTLTGSIPETLELPSIAYLDLGHNMLSGPLPTRLAKQAMQVRHIHLEYNGFSGNLPVEYLWAGKFQLLTLKVNNNQLTGAVPSGGSKSMVEYTLQNNQFSQPLAQLTCELDQALGLGGSVIEFEADCSICQCTGGIFCSTCNGGFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXM2</accession>
    <name>A0AAD2FXM2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS14965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXM2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1954373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="819" mass="89424" checksum="4E95D33EEFA6A04D" modified="2024-05-29" version="1">MIHSFIHGFMDSVANTNHRRIENRLCSSMPSFMASPMPFASPGREAYSENAPANDKSSVRLSCLSPDGRSVHSLSIVRGQGLIETRTLPLDGTVEDNDASPSGPSLIRAILPEQISQALRRYPAIALLCVDVESNATSTVHQSLPKLCLYTQRDVFVLEIGYQVTPGVSQTDRTVVKVTEPFEGVLLGSSPGTRVVCIRQAPQRHNGFAIMCPPKSMAMMIFDPESSETSVVLYHGTNDTTTTALVYGQELYDKKDHFTNFCFGQSSALSLLSNTSIMMLKGSGDVYIAGPALFRGSVVPRALLDTSLEYLRNEIQQTEPNTPKWRQTRLALQNLADAFPVGVKAQFLTAEAQSPIFEVPAQLQGPALIGEESDELESMATCIESFAAGNLVGFAIGHTEGIVEFGVLVPSTLVPRFASESHKDMQVLDDEFIGGMVITRIDLRDEEGDFDPTSSMNLVKDPLIDSVLHCVTGTQIISVSTNTLKIIAKELSDQVGTGMMSPILKPKTAQPNTTAWPCLDVTSTEGNINRVVGAVVSGDVQFGHVLIARLSNNSMVAVNLTEARLLKEMEIFDKKEAGSASDARVAELSNIAPLHQIIEPLAKQVVEGLGGLTKVVGSATPIAAATPDQLAAAVAIKQSCDEKIYLPLIEITEHLKSRKEILSVMYKNQMLQLDAVQNMISKLKEREAIIKEMTDVAKANSTSLSQRSAAILQSSNDLMPKLSQAEYDYFQELRKLEEKTRQWTAEFEGVHSRVDSLQQTVYDDTMQTLDALPQQRTELSQLQGKCTTLLAIFEDKLDDAEMKLDDIADAAGMERDSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXW2</accession>
    <name>A0AAD2FXW2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS16185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1956341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="304" mass="32652" checksum="B14F154BDD658BD1" modified="2024-05-29" version="1">MARMTLDQGADVQAKDDDGETPLCVACQYGHHAVAELVLEHGADVNEKYTQGFTPLLVACSRGFLQLAQLLLDHGGNMADTTDSGKAPLHVACQSGHIEIAQLILDLGGDVAQKDSSGWTPLHFACHSGHSEIARLLLDRGGDVFAQNDDGFTPISEALESVEVTRALLDWGVDVNARIEKKCTLLFLACGSGRIGVPRLLLDRGADVNAQNINGLVSPLDTACLSGHFELARLLLERGANVGAASAKPLSIACRNNHLEIVWLLIHRNPCLILDGASTVLHQNQERMNDTTESGESARKRQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY87</accession>
    <name>A0AAD2FY87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="100"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="175"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="278" mass="31966" checksum="AC1934E4EC72E65E" modified="2024-05-29" version="1">MLEECLLALLRQPLPSPLLDLPVQSFEDPLGDPKMEPLPFRVSSSDQSETDPEQNMTFKDEPIVVASFYHDQCDDVSLTSSSGWSRTNVAERIPRFRPYQDKKWKSSFQRLINFKNEFGHCCVPHSYSADAALARWVKRQRHQYNKFIGNNGSSTLTTSRLEQLESVGFVFHSHAAAWFERIDELKDFQQSSGHCNVPSTYPENPALATWVKSQRRQYKLRVSGLQSTMTMDRFGVLHSMGFLFEPRLAAFENAQLEMKTRKKNVKSFGPSRKVLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYZ4</accession>
    <name>A0AAD2FYZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001946">
        <property type="protein sequence ID" value="CAJ1957443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="133" mass="14939" checksum="3503442F61F23185" modified="2024-05-29" version="1">MGKSINAKASSAMTKKSGVSKMKTSSGAKKAVKKRVEIDLQQPKDRDPIDSKMVSETQTDETRVIDDNEAQRMADEIEAKRIAEREARRSGHYDSIAPNLSEWWMKNLYSGDAVDEALERHDRIHTGNALFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZK0</accession>
    <name>A0AAD2FZK0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZK0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="98" mass="10941" checksum="D3A41B721FEFF5C1" modified="2024-05-29" version="1">MKISKKNQTSTTEKAPKKGLLGKLGLKKNKKAKEGEKPVEEEKPVEEEKPVDPEPVKEDARELEKPVQSVDTEATKDDTEREQPENKPPTSPLFCGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0B1</accession>
    <name>A0AAD2G0B1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS17307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0B1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000014">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31469">
        <property type="entry name" value="OS07G0633600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31469:SF8">
        <property type="entry name" value="OS07G0641000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1958700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1125" mass="129487" checksum="AD34D935070B5402" modified="2024-05-29" version="1">MFFPKSGNRRRSPYRSARSVRPQKEVPTHMVTNWTRNKVCVLLAGVFIFGTTFLVPIMMLEKSMSQEATIPMNSKNHISLNHLFDKTKKMEKIIETKSYSVLKKAKQALRKGGHFGIPEDEVNNRDPFELHDNEDHEAHPEEIEESLARGVVGLPMSKTPALIGARPGHIACEVNVDDMAYWNDPQGTRDQEFQSPFASSEPESHYITFEPDPGGWNNIRMSTEVFFVMAAATGRTLVLPPKAPMYLLGTGAAHARSFGNFYPLSNPHLKKRVNVITMKEFVEKEGKSIMNLSDEELEQLLPIAEMCLHQKNSPIICENLYKVLREVGMQPDMHGAHSCYIFDKDKFEGKEISDDVQKRVDRFCGEKRTATFYDQSLHTPKLIHWNADAPTHRVLNHFYTFFYFTDPKIDNYFKRFVRDFMHYTDEIYCAAGKIVHALNDEGKGWSSLHVRRGDLQYKEVKISAEEWYNNTKEIWNDGEILFIATDERNKTFFDPIKEHHEVRFLDDYWDSANLGEMDSYFLGMVDTIVASHGRAFAGTWFSTFTGYINRMRGYLGHSTKTMWYSWLPRKYAVREWTYPEGNYPAREWPIGWVAIDGDEVIEHENEKADSIPDPPDPNEITIEAIEKVPASVAIKNIAMSDLKSDEGFADKPVARGVAGRPMSETPALKGAKRGKIACDVNVDSVAYWNDPTGEKDQNFESPFRAKGEEKFLTFTLDRGGWNNVRMSMEIIFIIAAATGRTLVLPPKEPLYRLRADAKNVHRGFADFFDLSTPEFAKRLNTISMEDFIKMEGGEHGRLPIPEETRQNVTNSAHHCDKRKMSTAYCGYIDDYLATAGYVPDMSAKKSCAVFDVDKFNGKELSSASEESVAKFCGDRERYYFTEELQENTLIHINAGQKELRLLTHFYDFVHFTDPAIDNYYKRFIRDFLHYNDQIYCAAGKIVKALQKEATDRGFSVDEEGAGGFSAMHIRRGELQYQKVKIPAIEWYENTKDLWEPNEIMYIATDERNATWFDDMAEHLELRFLDDYFEFAQLGEMDPNYFGMIDTIIASRGRAFVGTFFSTFSGYINRLRGYHGMSMMDSWHSWLPRKTKMHEWEDVDHFVFSYEWPTGWVGIDGDVVPSKDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1H2</accession>
    <name>A0AAD2G1H2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1H2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1957122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="226" mass="25560" checksum="912C5F5868C02304" modified="2024-05-29" version="1">MTLTGTPPEAAVLAAKRKRKVQFGKTEQDVVREFPRNPRETWYSDDEYREFKRTWKINQVRIEDAQQELGFCFELLGLQDPSDGAHETFAKGAWLSRARLRQVVFKHQDDCRSRGAYDPDGASRLSKSCSDKDQTKALKAAAVNAEAAFQYRKDISAIQPSPTSVSNFPPLDFSSITDPFECGVSFSCVNWDFDVIDGNEILNYTKKFDRHIEQTDTESVSSEGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G225</accession>
    <name>A0AAD2G225_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS18457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002040">
        <property type="protein sequence ID" value="CAJ1960041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G225"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="239"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1960041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="669" mass="76082" checksum="A8A53CF03B4C1897" modified="2024-05-29" version="1">MIQSSLPLQNLCARLPIGRRNLSGFDLSALSSRLLEVVRSGSLNPPNPVLKSLRNKADDCWHPEFRRMLPYHLENAIQSTRTQYSVDLAELEVAITAGVDKETQWKTTLDLLNRIDEIEAPLYQIKEVGQLFSELAALPDQQKQWQEAHRKTRSIRGALRPFTGSKIIYQTLTEMAGSSTDAHFPIYLRLAFERNGLCADEGHPDKRQQLVEIDEKLKSLNRQLQSVVERSGANKSDRLSIVKYMYNIIGLTHLQAQHLGYSTVSSMMMHERNAMSSSVEEVLNQNESLANILRPYVPKASVTLDEEAGAFLPSSKPKAPTDSEKELWIAKQSFKKLVYLDGTIQAIVDFCDSILGINIVENKDASSLGWNQNVRIFDVANKTDGSSIGTIFFDPYNDKYWRSSEASETTMSRLFSIRPNQTRFPVAVIGLSIEPTWDDVPTPLSWKDFQDVLFHFGNALQMLLSQKAKIDNKTPYYLQPSDVSHFLGKFMVLWLYNDGFLERLAQLSQDQFTFQPELMRVLRQEFKKQRATNLMENIFLCTLELAIFTDFDPRGDETLVSLQGRIARKYVPYDMPDSNDLGPMIEIFQCKNLDPKISTNCPVHSEMLACMAYKRFMTTDLQNAGAVEKLGQGIRNLFLSPETSSKEYFESLCDATEISVKSLRDVHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2K7</accession>
    <name>A0AAD2G2K7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2K7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="137" mass="15778" checksum="9D4BB32AC9B038EE" modified="2024-05-29" version="1">MITLAEIRQQDIMNKTKDLFGPIYALRPEMDIVCERGTFANENPRNQVLIDKIRRALPDYDSASLHLKGRGAMITDFFTQVTSGGGRFLMRIHETTQEWKEINDKARRDKISYLFRDEARKARNVEASFAALENVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4C4</accession>
    <name>A0AAD2G4C4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1962117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4C4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052660">
        <property type="entry name" value="Erythrocyte_Invasion_ImmMod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16021:SF13">
        <property type="entry name" value="ETS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16021">
        <property type="entry name" value="MANSC DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="638" mass="71734" checksum="09BE3C0C6A5A77D0" modified="2024-05-29" version="1">MAARARKRTNAANAASNAAAANNAATQNKRRKPTNTQPLGLKLMDDNNNSSSSSSSSNANDTNGTNESTVVRLYVGNILGRRPTKRVPANIVTPVRPVDIGIVDCHIPRKLLQVSRVTPETLELDVFFDRTEPNNEKATKAHRKCAKLAADICKITRNDQVLQVERGRTIVLEPHDILVVAKTCKGCDFFYQFQVLPVAQETASISPNQSMEDQDSTVKEEDAPDSLAVMDAELDELEQKLGFRPYRPTRTMGSTCSNNNSTATAAAAASSVQTRQSPTNRNNMATPNKLSQDTVDSESEDETDVKDPQKTTTMHATLANTYYKALNTSTPHFGSSLLLLTRSKQEFPTPHLVQDLIKLLTFGPTYHEDYAFYEGNRLQLALDYVQILLRLYPKDMGPRFLQAAQQIAGENGDYWRLCLDQLSILPYPHSMTTTTTTTTTTTTTTKTESSEVAERKRLLQSLEMHAVSLQFFQILLQQTDLLSRQEQIHGNTAKDFIRHLARIMAQTWVSRGHYLLLTSLQDQPLVYAIEQVTQLLTQVLGCVVNPEFVDNDFQEQDLVDILWNAMDEQQRQQQQSWQEMQTKDKRQVLLTWIFQLEGLSMTTTTTTSTNIKWTRVTDGLVKRARLRKEYNALALPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4J5</accession>
    <name>A0AAD2G4J5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS19471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="6">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1961988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006970">
        <property type="entry name" value="PT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04886">
        <property type="entry name" value="PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="765"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="776"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="856"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="881"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="906"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1961988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1301" mass="141590" checksum="12A834098B53D1D1" modified="2024-05-29" version="1">MSIEDEKDAGNQEAGEKRPSRESKSSKDNGERKSRSNRHRSSSRDSQDDILGGSERKSSGAKPERRKSKDFDALGGSDRRSSHRPSRRQSRDSHDGNLDTSKRSSGHRSRSRDTNDALVNDNELGGSSGAKPERRKSKDSDALGGSDRRSSHRPSRRKSKDSDALDTSKRSSTHRSRSRDSNDSLANNNESSVTRDEKAKARSRRKSSAPAMPGAFVEAAGEDRAVRRKRDSADKGKESLGTKDRDTTDREAKNRARRQPGETMLGTSQESKDRRAKDQARRSVGGAVRPGASSETRGSRQAKTKRDISRRSTGASENEIGVPAANSVGWTGDVEAVEAMAVDEMASTPPSAPQEVREQTLNQSTEEDGNKAIVATARPDNKGRKYKYMLAAFVVFAIIAGVLVWLLVLRESSEPDDVSATSIFSPPTTEDCQTISEGMETAGQMGTTVKYFGVEMDFEVAPDVDLEFLQSELQMRIQRDVLPLVAGCDKESSTSTGSDTFIVENGVLKTISIGDLVPCSSNPQGLCSFVYLQLDVFSKDADVQGAVLLGLIFDVFQEDGLLQDPKLLSPVEDIDFITAYEILPSSNPSSSPTIQDDGGVPVDNGSPSQETCDAIANGTPVLGQDDLVAQEYDILMDVTLDSETEELSPLTMELDEKIQRFLLPSLAGCTIDRRRRLQIESFVVNAFVDSEVSIGGACLPDSETACYRYVIHLDIYVQRTVASADFSSDIVGKFREAPLVERLGMLAPFKNIVIVEIYSDAVFSESPSAEPSNNPTDSPSVNPTTAPVTYPTTEEPTRSPTIAPSFAPSLSPSSNPTLGVTSAPTLIPTLQPVVGPTLEPTPLPTPLPTPAPTIADSASPTADPTTASSLTPTAEPSVLDSAQPSGQPSGQPSLLPSVQPSSRPSKSPSAQPSALATTQCFESNTELSGALGNWFDSPFGRQITETQYGLIGDWCFGAGVTSMKDLFKNRATFNSDISNWDVSSVVNMQSMFQGASSFNQNLSLWDVSSVTNMRLMFEMATSFNGDISTWDVSSVTQMNNMFQVTFKNPSAFNQDLSQWDVSSVTNMHSMFYGARSFNQDLSGWDVSSVTNMAFMFYETPFNQDLPLWNVASVTKMNNMFQWAGSFNGDISTWDVGSVTSMIQMFDEARAFNGDIASWDVSSVTSTDRMFSNAAAFNQDISMWNFASCTNMILMFNQAESFNQDISSWDVSSVTNMRDMFQYASAFNQDLSSWDISSVSDMRRMFQFATSFNQDLCPWGPILQGNVQFEGLFASTNCPLEADPDLTATPRGPFCNLCVPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5U0</accession>
    <name>A0AAD2G5U0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5U0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042204664" evidence="1">
        <location>
            <begin position="26"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="244" mass="24174" checksum="011DA28703B1F334" modified="2024-05-29" version="1">MMTRFMTILSLVTFLVIGLGNPAKADCTGCTDNGCTCIGSIGQGCDQSNCTIAARCDAGGCNQDGTMNPDCCFGYCSQVNATGPTCIAGHCNQDGATNGPVCTGGDCSQVGAENPVCTGGKCDQSNSVSPMCTGGSCTQTNARGEADCVRGSCNTAGAETVSCLGGSCCLDGTETSVSCVGEGCNADATSCNETGCGGSPCDSTSMPSDGGPVQCSQDSGVSVNANQALKLLLAPIFLIVILCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G852</accession>
    <name>A0AAD2G852_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G852"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="371" mass="42402" checksum="0F86C838A2C99BD4" modified="2024-05-29" version="1">MKNHQNGYRIHSALFLVLIFGGSGSTAGFLMTIREEPQSRRHHDRGSSSARSPIATPIILTDHIRQRSLVSLQMENPLATEAALSEQSNAMKKQQQDSPFLGVLQLILISLVSAILLISWEEVSMYHPIRKLPQQHIQQQQAVYHWGDSTVRGLAFGKAQRIRLDDDAEPQDSQYYIPSYNEIMLEHRTERIPSWNDGTMTEDKVRQSVATIQTTVEYLQDCKRLANEYDWDGLTLAIRQPILHQQLEQACNNLKHADGFLSPDARDEIGFEWASCAWRHCGALADAQEAIDELDHLIGILEPFECLFCIDIVERSLYDILAVTQKYQDPSIPVPEYQQLHRKSDVGPEGVDQFDTEYLEALQFLKKFENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8R6</accession>
    <name>A0AAD2G8R6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS21530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8R6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="100"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="209"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1965944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34384" checksum="2E3CB00FB8F1573E" modified="2024-05-29" version="1">MTARRMETLKFLSGGVAGTVASVVTNPLEVIKTQLQSSNTALLESKSPIAIAKAIVKQDGIPGFWRGLPPTLVGIIPSRSAYFYAYQRVKKLLSPRLPEGSPGNALVAGFTAGIVGNTLTNPIWMVRTRMQLMVDANAGQRMYNGYVDAIKTIFQEEGIGGFYKGITASYWGCAEGATQFLIYEQIKTRLLNQENERRAKAGMLPTSELSKASYFWAAATSKFVAAVATYPHEVARTRLREQAKSGVFKYSGMWQTLGLMSKEEGFKSLYSGMGVHLMKVVPNSATMFLCYEIVRGWLDTYTIVALVPTKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9G1</accession>
    <name>A0AAD2G9G1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS21949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9G1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1966365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="70998" checksum="2741C46C8F9E7048" modified="2024-05-29" version="1">MTHDHDPLRLAPPAKTLETVTDCPPFSSPFSNSKGGRWEGEMILKTLAIFCGFLSIIASVWIVVEVLKEPSKRSNVYHRLLCGMSLWDGIVSAAMFLSTWPMPTGGEDEDNTVWAIGNELTCLIQGTFVQFSIAPPIYNFCLALYYMLVVKYKYSEKQVKKIEPYMHALPNMVGIGTALFGLFHGIYGSALLWCWIEPDDTQFRWEMYYIPLWIVIILITTIMIVVYRTVERREMKLILGVGDTTTTTGNAAAAAAAAAAVTNNATNRMSLTSQGSERSFVVQQQQQQQHHNAFDGNSSFRGSITSGTDHANEGLLLLPESMMDALRIARASRSSGGGGGGGGGTITPLVGAPSNDRHGSSTNFVADALQRASLNHANLNHTVGPKNPSIISGGGGGLLDADQVMDAIGGFASVKEQQSVESNKLGSRAVFRQSLYYTLCFYAVYAFPTLNRILELHGHSFFLIFLLHGISIPAAGILNLIVYRYPFYKRLKQRYPGMSRWQRVRRSIRWSFLGPIKESNKVTPSQMQSQKSKIDPRNSSNMHSNLLEGSTAGNSQQPPDLLSSEFDPSIYRSSFMQTIIDDMLHFDDQDYIGNNIDLYNQMESDLNAVYSEFPTALTEDTVVVPTDFPVVLRRESISEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9L8</accession>
    <name>A0AAD2G9L8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9L8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15291" checksum="E75644B1AA8D4EAF" modified="2024-05-29" version="1">MISDNAKIGTGLLALGIVFLFLGVIFFFDAALLALGDILFLIGLTLTIGPSRTLRFFSRKDRIRGIVSFFGGIVLVMVRWPMLGMICQLYGMVYLFGQFFPIAAQAMQDTPVIGDILRYPAIENFFASFGGGNNRRAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9P6</accession>
    <name>A0AAD2G9P6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9P6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="373" mass="41454" checksum="11E3B8311CC4744D" modified="2024-05-29" version="1">MSFHFGEPTQRNDRRKRRRRSFVDHAMTVTVSDEQQSQHHPNQLSLTYSSQSPTLLSTGAQNLSISIPTASFDDTHFPEGCTPIHRGQHKPSVKEAVVSYHGGLAQQLNKEGVQCIHRGLYEEAVSKIARAIQLFHSDGDLSNRSSISLGAILNHHFQQPSPGSSTPSLTETNPDDIDDRNDVETSRERDVSDDTDGDFVYSSGIMLPSKFQSHATGETLLVVLSFNLALAHHLSWTTREAASDTLRLSHMVQLYELAYRLAFQIQANSSDDDISPEFSEICNMRFTLIIINNLSQIYQALNGEDNYHRVLEGLLSHLMVVAVVQQQHSRFATADRNRGGVDRYGAASIAINLDGFFQNVLPLLLKRNSAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB89</accession>
    <name>A0AAD2GB89_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002274">
        <property type="protein sequence ID" value="CAJ1966318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB89"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042007537" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="50" mass="5016" checksum="D9058FAB8A4C8050" modified="2024-05-29" version="1" fragment="single">MKFISALFFAAAAIAPVTADTGKEEPAASIIDLAAADGKYGTLLSAVTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBA9</accession>
    <name>A0AAD2GBA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ApaG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002407">
        <property type="protein sequence ID" value="CAJ1968810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBA9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050718">
        <property type="entry name" value="ApaG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47191">
        <property type="entry name" value="OS05G0170800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47191:SF2">
        <property type="entry name" value="OS05G0170800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="1">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="179" mass="19703" checksum="A30BBFB6F574762F" modified="2024-05-29" version="1">MHRLSSFATTQQVRVTATSRFIGTSNPAFHFPPAVTPDVLRSKYRFAYRVRVENLSSHQYVQLLGRYWEIQEHDGPHSQDAVDSPIVVNAPETGAVGQLPVLRPNQVFEYTSGADLGTSRGSMQGHFYMAVVPEDAVCLNSGDDVDIIQESDKFEAVVAPFPLVGYCSSNLGPQSEIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBN5</accession>
    <name>A0AAD2GBN5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine cyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBN5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270:SF1">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="44111" checksum="1A0A3395755D51BA" modified="2024-05-29" version="1">MSTGSKIVSFHRKTKDRNDAAKFHRHYTFEIIPKTSLSGAMGRSDMEDGSIEMREWNDAEVRTGEEVGYDFDESDGWGKEDRGQCNCKGFVYCLIVTAFIGACVGVYFAVDSGLIALPGAEADSVEEIVEMKNCSLEHHIEWYQKPITTKDGQQYTVIGQIDHDPTSFTQGLTFANGVIYESVGLFKQSKVRILDPNSKEGDVLKSVDMGPKLFGEGMTVWHDKLVQITWKSKRGFIYDIESLEMVQDFKYETTNSEGWGITFDWCKDEFIVTDGSPYLHFWDTSTLEETRKVKAHRLSGEPAKNLNEIEYWRGRVLANVWFEDVILVINPDTGETEKEYDFSMLWPADERHQVGADVFNGISISDDEDMLYVTGKLWNRIHSVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBY1</accession>
    <name>A0AAD2GBY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002413">
        <property type="protein sequence ID" value="CAJ1968916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042207631" description="VWFD domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57284" checksum="6344B643260DA38A" modified="2024-05-29" version="1">MKVISSLLSLAAVATIVPTAVDAARADTCEDQSKCIDFEITTLGADACGVGGNCTVEVCMRIQAGSSNNFGTCPKDVGGGGFSHVCSQTDAGGCPNWGDQAETIPLLGQSDGTDCTLTGHGSGAPAFGDKCSGEDTIVMCQEGAPGATLYWIIKDGQDTEQEDPQTLYPFIWHDTHQCGAEVKCFNYVYKCGDGKSDTQTKKERTWTFKIPDSDGSDCDPCTFYPPTPTPPSPTPPITPEPPIVSPPPSPTPVAPVAPTPTINTVPSPSGGNGDPHFKTWKNEHYEYHGQCDMVMTKDANFADGLGLDIQIRTKLVRFWSYIRNASIRIGSDIIELEGSSDSEDQSIRYWYNMEFQAENANTLGGFPMTIRRIYSMMTKIEIDLNSMYPGVTIEMSTYKEFIKVEVKGATEEAFGNAVGLLGDFKTGKTLARDGVTELHDWNEFGNEWQITPTDDMLFHSTVDPQFPERCIVPEDPRGDRRRRLGESNITMEQAEKACSGLKDSLDRKDCVYDILATQDMGMAGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBZ0</accession>
    <name>A0AAD2GBZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1995 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002413">
        <property type="protein sequence ID" value="CAJ1968946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053021">
        <property type="entry name" value="Chloroplast_ADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018962">
        <property type="entry name" value="DUF1995"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF1995)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509:SF4">
        <property type="entry name" value="DUF1995 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09353">
        <property type="entry name" value="DUF1995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041993047" description="DUF1995 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1995" evidence="2">
        <location>
            <begin position="40"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="294" mass="32979" checksum="351FF7DEC610326F" modified="2024-05-29" version="1">MTLPIMMSTEILLLLLLLLYCEAYSVGGFSHSPASVPKLPENPEDVARQASASIQRAVLDGGIHRQTIRLPLSESMYARKEESFVADRAIGWQGGPQETYRFVSPMTESVLRQISLNDDKNSGLTPKIQRQILLDFDGSALLNAQSPMGALYDSLALVQPNTDNYYMELIEKVENEFSDTPGKAKRLFLLINPAWKDDPSSWGIFQSKKAKDKILDRYETTFALDQFIVKGNKISLFKSYPFDWTAYWTQLRPSGTRESDDSSIEGATLLGSMPKRPTYLEVENMLDSAMAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCG1</accession>
    <name>A0AAD2GCG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS23762</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="178"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="305"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="379"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="452"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="683"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1969542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="812" mass="89430" checksum="3E424414B53241A7" modified="2024-05-29" version="1">MVVATDCIIEERVNDHQQQHSRSWIDSVASPISLLDRNQCVIGWNQQAVDITRINGQEIIRQPLRQFLLPESSVVFENAVNEIEKGGRQNKCLQLAFSTNPEGDRYHVKLAARLDNGGSYCGLLLFFVDAIMTSELPSSPVSIINGVKSLDSSERSHFSIGPPQQQQPQNGMDPAAAMAKECRTVLETANAPIFGMDCDGNINEWNLKCVDFSGYQKDQVLGCSLVNTIVVPSMRSPVQQVLNDALQGNGTSSYKVDFQTSRNEIRHLLLNASTRRNASGDIVGVVCVAQDVTEAVHRDRAVGGMAAELRQLIDTANAPIFGIDTDGNINEWNKRTAEITGYPKEEAFDEPLVERFIAAEMKEKVEEILSNALQGNETSDYELEFISKSGESVFLLVNATTRRDPENAIVGVVGVAQDVTEDKKHREALRQMEYLRASQEAKVETERNMTAYFAHELRNPLGAIDSALNALPNDLSEEASSLVSGMQLCTGFMSSIMNNLLDVRKMEEGKMTLMKAPISLKKIISNVHKMLLPSVRPGVEFLKKSDTQGKDWIIGDSHRVQQVITNVVTNAIKYTVNGSICLSVGWEGDMVKFECEDTGPGIPKNQQSNLFQRFVQRGGAPGTGLGLAIAKHLVDLNGGSIEFHSDPSVSAGTTCVIYMKLPICEEPKSIVEESSSVIEEPLAILIVDDIKMNRMMLKRRIMKGIAPNAVIKEAATGEAALEICGNRSFDVIVVDQYMEEAGGIMVGTDAVFAMRRMRIDACIIGCSGNDMGTQFSEAGADFNWQKPIPNNTQIIQDIRKSLNEKRPNFLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD37</accession>
    <name>A0AAD2GD37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18037</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002011">
        <property type="protein sequence ID" value="CAJ1959617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002491">
        <property type="protein sequence ID" value="CAJ1970306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="853" mass="96211" checksum="5AD8DC9C406F04DC" modified="2024-05-29" version="1">MNEEHRYTGQTTTELIKRTGEQPPKHANGRELCLIWHTKGECKENCEHDAAPDIDKLPHPAAPMLHRVMKNGAPVVVHSEPWSQSQLDMRVARGCHSSANEFKEFLMEEFLDFGRKGFWILLPYDAIKDEKGLCLSPNGCVPQDNRRPRMIVDYSFWGLNDKTMKLAPEGAMQFGTAPLRIREALMKANPDYGPVYMYKNDMSDGFYRIRLSTTGALKLGVILPRFEGLPQLVALPLVLPMGCTESPPWFCAFTETVADLTNVDLQQNKRVPPHPLGKAAAITDFEVRDAQVVRPIPKSHQPLTYQRPLKKMEVFVDDFVGMGQDHPSNPLTNQRAVLSHNIDKVFQPNRPTNNQWRKEPQSQSKMAKGDASWHTIKEALGWNWGATTKTLQLKEKRVSKALSLLGKVLDCKRVSLKRWQQVLGVLRSLQPGMSGSEGHFSLLQDALIRQVDCRVRLTPEVHEQLEIFQDFLHGHAKRPTTLEELVPGVDLHVGACDAAKSGRGGVWFTDDGEAIVWREPYQEAVKKEVISDHNLTGKLTNSDLELEGTVLHHFVLGKTAQVEGETTYTGCDDTPAVSWRTKGLSTSRKARARILRLAAGLQREQRAHHHQLLATVQDAKRRELLDDIRAVELRIEHGVCPSKVAKAYSVWTTWVAFCDSLTLDPGLSAVDDPLLIILLFGTQWRHGKIAPSKRQVRGQTAEAAMRQVGQAFSSLGLLNLRMNRYAPGTMDFCWTPLLKSWKKEDPAAQRVRPLPKSLSRQASKLAKKPTSTHAAKLMHRLMWLGFFFLLRSGKFLSKGGTQFPFKLKQVFFHINDAEFRGDVIPLRLLDMPLVTFAGLIFDKQKKTVPDKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDH6</accession>
    <name>A0AAD2GDH6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36503:SF3">
        <property type="entry name" value="BLR0126 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36503">
        <property type="entry name" value="BLR2520 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="126" mass="13685" checksum="F491411342C002A2" modified="2024-05-29" version="1">MILDAVGIVCGDLKQSTKFYGLLGLEFQSAGGPEHLEATTPTGLRLMLDSEDLMKKINPDFVKPTGSGMTLCFKQESAAEVNKVYDSVIKSGYVGTKAPYDAFWGQRYASIKDPDGNPIDLFADLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGM0</accession>
    <name>A0AAD2JGM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="374"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1947747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="80848" checksum="E59E900D0801F072" modified="2024-05-29" version="1">MDPVKFVPFSSTVDSPFWVEYCHLKLEDIQLSEDAISMQAQVQPISSSNVARLQCLGGGSNSLTHSVRKLTPTAVQRSSVDKMIFQGNLVGFNTLETFSKVDKNKLLKEHFLKGFLSSEEANDEQILKSLTSFILLTFPDLKQHKVLYWFGIPALMSKTKLQAKRLPSFSSEEQLVLEQAFHSFRREQESNQLPTFFVFSNQDPSDIVIHPLSKDSFSKLSKDHDGSAEQLVFGFVDSTTVTTDTTQQVVPPMGWPLRNLLAYLSIHLNLGGSTISILSFRPNRLHRLVDETIPSVNSSSNNHIQLQMAVPNKEDYSFEQNNTSDNNNPYDKYKVVGWELNARGKPGPRWVNLKPLLDKNHLAIQAADLNLKLMKWRMIPNLDVTRLQSTKVLLIGAGTLGCSVARTLMGWGIRDFTILDYGTVSYSNPVRQNLFALEDCHFNNGQGKPKAQAAADALKTIAADVKSRGIHLSIPMPGHSESLESVQESVSQLDTLVQEADAIFLLTDTRESRWLPTVMAAAHDKILINAALGLDSWLVMRHGGGVGNRLGCYFCNDVVAPENSTKNRTLDQQCTVTRPGLAPIASSMAAELLVSIMHHPLKQLAPAPKTRSSAFSPTVSKGGDDEEEEVSDSSPLGVMPHQIRGSLVSYTMMTPTVPCFTHCTGCSQPLIDAYKKDKMELVFETCKSVNGSYLEQISGLEEFRAQAAAKMAEMDEMDWDVEDDGDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGU2</accession>
    <name>A0AAD2JGU2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001728">
        <property type="protein sequence ID" value="CAJ1947491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGU2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="354" mass="41080" checksum="5EDD74B0D2EA2842" modified="2024-05-29" version="1">MSGRFQNTGRGSNGRNAGRNSSQQGQSNCQYNGNKSGNGSQKEKKFHPLTRGKIPEFSFDEVKKTLGIKMSTMKMDHIDDMIQSVRTMKLFDIQSVKPALVLVTNDSDPDKEIKNEERRTNYLADRKDWKARKNAFDNNKRNVYGMIMKMCTDHMVDKLEREADFENKLFNDPVELLMRIKKFMTTTVDTEWEYFGLWKTMSNLINCHQKEKENIASFRKRFEERAKALQALLGDDFLDKFTEESQEYDLLGSDAERSQHKKESWERFMANGFLYNSDSRAKYQSRIDGMTAQYTLKHLDFKQHCTFPTTLENAADVLNQHKHDNRKKNLNGGNSNGQGKQNKSNNNQNDGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHL6</accession>
    <name>A0AAD2JHL6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001791">
        <property type="protein sequence ID" value="CAJ1951631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHL6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="420" mass="48456" checksum="792A44E956A79425" modified="2024-05-29" version="1">MKKTKLPDAWKKTTAELETALRNDRKEYLHAKKNHAVTWRKEFLTIQVKQSKKKQWTSRKARDRFLRLRRMKQREEARRRRRAQSKGSTGGLQAIQVEEQLPNGQVDLRTLTDRRQVEQGCMQENRARYDQTRSPYTTPPMDEPLYSMFTGADAERNSHALLEGRLPMPDGIDSYTQLFLEQCRFHQGHSMIPMEVSPDDHTYFWSPNPENKGSEPHGLHNGHFKAGIYSPTVAQCDALFRHIPLTTGFVPDNWRHLMNFAIGKKPGDFRLTKMRTIQLMNSESQANYKKLGRLAMAYGEEHHLLADGQCGARKHHQAIDLALSKRLVWDLLILQRRSAGWISNDAKSCFDRVVHWVAVIAMMRLAITWNALRMMFDTLATSTHRVRTGFGDSEERSPFYCTISGLRPGQRSGPAHLSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIA4</accession>
    <name>A0AAD2JIA4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001812">
        <property type="protein sequence ID" value="CAJ1952658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1952658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="219" mass="24981" checksum="36911D0D918A99EE" modified="2024-05-29" version="1">MAQNKILYSAKLDENMRRSAYFKTNKRTVKSNIMLKFVMKAMDIKLRGEAGFTTTLEDPIELLKCTEQFMKKSADAEYDFLDFWEANQKFFAMKQGTTENLMHFKERFLRQAEVLQDLYGVAWFRNFAVKTKAYAAIASTNTAAQNKFKDDIFEAVLATGFLCNCDQTRTAPLMKAQRSRLQKAKADDEFRLASAEVGALGHAVAMQLTTTRNSQATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2024-10-02" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIJ4</accession>
    <name>A0AAD2JIJ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001848">
        <property type="protein sequence ID" value="CAJ1954021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="49560" checksum="F82C999D985DC3CA" modified="2024-05-29" version="1">MDVPNAFIQTYMPEAKEGEDRTYMKITGMMVQILIDMAPEYCEYVVLENGKRVIYMRVLRAVYGMLQSSLLFYNQFRSDLEAKGFVFNPYDLCVANKVVDEKQQTIRFHVDDLMSSHMDPKVDDEFAEWLNMRYGSIQACKIVRGKIHRYLGMTLDFLVKGKLKSRMDDYVKNMLEDFPIKFNKDSKQETPAGNELPEAGKGKLLNAEYRQIFHTTVARGLYVSKRARLDTHPTITILALRVREPTESDWKKCVRMMRYLFCTLLYHLTLSAESLRVMKLMIDASFAVHPDFKSHTGGTLSFGGGAAQVMSKKQKLNSRSSTEAELIAVDDVVTMILWTKLFMEWQGYPIEKNILYQXXXXCCNQASYSIISFEVIWRQRDLFSIRMTCVLLTKLLMKNSKLSDFIFLTINIFLHNNYHQPFLIVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ19</accession>
    <name>A0AAD2JJ19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS15109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1954516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="507" mass="56791" checksum="E6FF83D66E7D222D" modified="2024-05-29" version="1">MSMENRSKDDTTTQGNDSSAVPSGFILKLYQMVNGAPDEVISWTPLGDAFIIGSDLVRLESETLPQYFRHNRFQSLVRQLNFYSFRKINRERNVWIYKHKLFHRDRPEDLHMVRRRTCPGVDGRKQRFSRYSAQKISNSDKAIQSSDDEHSLGSSSDDENESKKRSMGESRGSESKRSRRSLWYGGGGNSKTSNEKKVVDATSVVKSTTSPTSVYEPSTSLFQNEIDDDDSSANKKTNRMEAVEQAMIVSEVASKLEEHLKKVMKGRGGTRSRKGNAGIVTPPNGSYQKFEMSSRGLITYDDEYKTTYPPTISETDEASIASVTVTEDDVSEQLAVPKQFLVAPVEDVEKVKNICEEIRCCVDRSFGNSLTFQACASVAEFFMSTPPSEDVQCVSKKVLELLSTSSRLAADFHFYRAALNPCSANNDEPEASNLFEERHAVALQRSLEGAASQSDAVREFKIFCVNLIYKLLENMENYGVKEPFSPTVRSNLLHTAETWSKSVGNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKN0</accession>
    <name>A0AAD2JKN0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041947718" evidence="2">
        <location>
            <begin position="23"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="331" mass="36295" checksum="A81560E504C868CF" modified="2024-05-29" version="1">MKIQAYTWILLFFIVGSNTVQGLLPPSPSNKIAVHHHQQLSSHHRLAANEPIKTHRTVETSDASPNQIPQSRNRASSWFAAAYFFAACTFAWCEPMAVLAEITTTTTTTTTTTTDAAASTSSWTQKVASSLKAPTEDSPRIELPIISGASQQGSSTPPPLFPKPGSSSNNNNKQPSKNPPPWRVQGLVSLENPRIERPYGTDFMIVQVLKEAPPKEPYAVTDDTKKTVLGGAKIQVGKFRFPSSITLGLENAKVQDNWKKVASTKDLWLEVTICKEDSAKFPCAPEEQRYRAVAFSKLFNSPQISESSEDAAAIRLPATMILERINNADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JML5</accession>
    <name>A0AAD2JML5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JML5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="559" mass="62629" checksum="671E70E4C996C50F" modified="2024-05-29" version="1">MASSHQPMSDMSMDEQTRQKPASYVISPDNRSFIRNRHFTVYQPRSQRLPAQEGTQAQEEPEEYFQDDAGNPISPLSQAEAQHFFESQDGSDSSEAIISNSNVRSDSKLQSKPSPTTNPTIQHVPQHHLIIAISPSFESDSSNFSPSDGNDSLPSKAQQEVRRTPLSILKNSSDNNRRVGIPSARDDYLVKLQSEISLLHRDVLGMKESIDTLTTNLEKQKAARIRNYMVSKYGRHNTDSSSSADSSSLSGLENIDALMDECLNSVSEASERSTSQAAGVRNHMVSKYGSHNAISGSADDSSSLAGPESNDALIDECLNSFSEASVRSSTAHAQDMKSLDQRVMQQNERNQRRHRQRQREDQSQSPSITPTNAPSRREEIMSPWESIRTPTSLVWDGDQHVQRNLFWAGHIPCVKAKLRGGKDMTKDDRQKQIFLLLVVCLASIAVLMIMTDAKSQTSIGQVPHSRRPRRSSKFSKKLTIDEQSNSCHSLQETTKDGCTRHCNTNKPQIAQELLLWKSYREGKHSLDPWKAIVLSLRERNSNPSAENYSPLVSEFTFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNE9</accession>
    <name>A0AAD2JNE9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNE9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="560"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="684"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="769" mass="87063" checksum="B900F3FCDBA3511E" modified="2024-05-29" version="1">MSGDGVDYGYGYLTPQPGRPRKSLGRRLSLGAKRAFKSPLSPPLSPAASGEQKSSNSFTRVSMIGEANNAADEQSPVQISPPQSTGRRRLKIGNALRSTVHGGGDERSVSSQPRPEYKRGTSFTPRALKKKLGKNLMKLKSKNVQDPGDLEYLDDSDNSRASHFKGSSSSGGSLGILHNVEDEPAKEAPALPFDDDKSEAGTIVSKSGRRRKKKKDTGDDMASPLSTKKKTRSRSKSRRGAAGDDVSVKSSGSRKPRKASKSRKAKVKVNAWGEEVEEVSEDETYVHSLYGGDDGSTSKPRRRRRKKKQNSVEEDKAKEERRQAFKKQMSTDMLLSKKNSEEVEKRRLALEQELDAMFDRKLPKLKTEDEYTPPPPPPPVHPQAKRRDSAGSRQSRQLSNGKSPRSARRQPKDEEEFEDDTKDDDIYSQEDDLPPIRNLSFSQRRQRTTDVPEIPLKDQISQDNENSNSHKSEAYEYNMGDTTTDEDDEHIVETPGNSRRKTLRDRDGNESVSSKKSVSSRISLSSKRSPRFAKKSLDEVSAGGFSARRNSGKAEKRRFVDDMLDQLEEYETNVDDEQINLRKKLESMAMEKEYLEQKNRQLEFRVEELKEKAAETADRLDTAARNKNQSSKEIEQLQIENDILKQRVQRHEAAMLRMNSSRSIRGMRSIIHKGEDPEEHEQQLAEKDKEITKLKADLALLRDQLRYKTEDYDKQAVELHQARKEVAEARTTLKHTGTFKYHNKFEKLKEEKKKSKTGAEVALSSFFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP69</accession>
    <name>A0AAD2JP69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002413">
        <property type="protein sequence ID" value="CAJ1968922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP69"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042282883" description="VWFD domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="58221" checksum="E7785FDFEBD6C7DF" modified="2024-05-29" version="1">MKLNANLLSLAALAAFPSMANAAPTPDCATQSGCIQFTVNKLDSDSCGVGDCAVEVCMEVNSSLPGCVKSDTFSHMCMQSDTSGCPAWQDEAKTIPLLGAGGGTCESGKTYGEGSGSGTAIFAGKCEGKDDITMCQEGAPGQTLYWILKDGNVKNNPAEDKTFTLPFTVNKADAGCTGDVRCWNNEYNCGASFNKAQAPKERTWAFTIPSSDGGSCDACGSSPPTTPNPPPPPTAPTPNPPPPPPTAPPPTTPIEPAPTPRVGPTPAAPTPTADNTTPTPGSNGDPHFKTWKNEHFEYHGQCDLVLTKDANFADGLGLDIQLRTKLVRYWSYIRNAAIRIGHDIIELEGSDDPQEQHVRYWYNMQFRSDEAKTLGGFPMIIRRAHSKLTKIVIDLDSKYPGVKLVMSTYKEFVKVEVEGATEEAFGKSVGLLGDFKTGKTLARDGETYVHDFRDYGNEWQVTPMEDMLFHSTEEPQFPKKCLEPEDPRGDRRRRLDESNITMEQAEKACSRLKDPLDQKDCVYDILATQDMGMAGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPN4</accession>
    <name>A0AAD2JPN4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002449">
        <property type="protein sequence ID" value="CAJ1970032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPN4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="154" mass="18141" checksum="004B7AFF8A6B2DBD" modified="2024-05-29" version="1" fragment="single">MSEQCIPGSSLTCTPSVMIPQINTRPSQQQQHGDDDDDDDVKNDEIRDHRGRLRQSSQTKSSWWNPLEGVLGTFIGVPEETKEEVEQRKQEKEQQLQQQAAQMEVDLKEQMEVDLKEQMELQEEEEQMELERLGSQLERKKKYDQEETSWWDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPZ0</accession>
    <name>A0AAD2JPZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS23447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002413">
        <property type="protein sequence ID" value="CAJ1968892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="264"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1968892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="522" mass="57984" checksum="DA53DAE4DCE377DD" modified="2024-05-29" version="1">MADTTSDNETKRPSSTNKLDETWFYYQNPTSGCVATAPMTLRQLSRLFCPVREGLKPILPPQTRCLQVLQGEQFGEWKLASEFDVLREASAEWYFATKDSGSEGPFSCRKILEEKPRLVYAGGVTEEWVSVDDIPNLKLVLEALQNATSVIPKNNVAQPAASKEVVELQAQEDLESFLSATAEETKASVSGSKDVDPDAHIYESDGGTKYVQDPMTGNWVHEALALEETKKETTAPTVATTTTKTKSGKKKQKKSKFSNRNAKNWIYISGLPTDKGITEDDIHKYFSRAGLLDLDPESLKPKIKLYRTASGQLKGDASICYAKADSVNLALQVLDESPWDEKHILRVQKAKFEAKVTGDGSSAGTKRRRPASDAKRKVARLALLQAQDEGFGGRLSGGRKGLCIVVVKNMMDGIEENKLEDMIYSYCQEHGEVEKITCMEKAKVVIIKFAEPTSAANALGALNGKPNPSTKKKMEAMYWDGVTDYTHKDEESDEEERLDQFGQWLESQEELPDELRLKVADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PTX8</accession>
    <name>A0AAD2PTX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS10679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001712">
        <property type="protein sequence ID" value="CAJ1946538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PTX8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="149"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1946538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="22531" checksum="C72DEEF02946B8C1" modified="2024-05-29" version="1">MPRQSGMADREPCPWRIVDDVGGAFCMGNVGGGIWHTIKGARMAPSGARIAGSLSAVQARAPVLGGQFAVWGGLFACCDCSLTAVRQKEDPWNSIISGAATGGILAARAGPRAMAQAAAVGGVLLALIEGMGIMFTKAFAAPSPDDLLAQQAMDPTAPPTAGGLFPSISGPGSSLPSPPTPSNTPPENEPFIGADTTFSTETSSHNSSQSSSWWPFGDGQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUG8</accession>
    <name>A0AAD2PUG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS12515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="50"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1950287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="338" mass="38180" checksum="E77C0B86D75B83EE" modified="2024-05-29" version="1">MMNKQQQPLQVDLLGSSSASGASGETDTQNIVTSSALLSAKAFSSNSQLSQLNFPCKLHRILNNPEYSDIICWLPHGRSWRLQQQQRFEKEVLPIFFRHGRYASFARQINGWGFRRIASGPDFNSYHHELFLRDAPDMCLRMTRPSAAELAERKRSEPDSPPNFYLMPKINPESADPQQQPPQIPPVMVEGCSSSESSSAAQGDDYMINLIRRIAVYAPQQQDMMLQLELGMLDKQRQEILEQMKQVKTAFHGSSNHIYTADANVSRISPTMNFPSPQERESLQYHQVAKINHISNLVGASSSDAQASFQHQPMISNLAQRAALEMYLQQMGQIPSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVB2</accession>
    <name>A0AAD2PVB2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVB2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="392" mass="43757" checksum="1243B9EBBD86D231" modified="2024-05-29" version="1">MPPRKTGHQRHGHGKTKDKRNSDYDPPSKSMDGKVKEFGKKARALLQEEKDKRREIKVVDPVQISTKTKSSTSFGSAIKSAGAATTATARSNKRQRVSSPTKRRRSEGASSAVTSKIHIHAPHIPIPDKEFRSNVVKLHGLHASCTKDHIKKFFSGLKFDFIFTVLSNDIYIPLLDCKKDLQETRASSNNDHHLRVFVKFESSTLATVAAERSGETISIGAVKTSSSEPTKVSIGVTLMSKELARRMLEMSIHGISNAPFYEVLSKIEKELHPIISTILWKRVAKTVEVPLEEEINQHDLFRKTNHDPSTLQGYQELARHCNQLIEIHETLINQLPSPSVELLASELSSTDPSVRLTSVAATVLTNEVSQLHKILCQGRVEARIQRQTEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVX2</accession>
    <name>A0AAD2PVX2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVX2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019309">
        <property type="entry name" value="WASHC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015">
        <property type="entry name" value="PROTEIN AD-016-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10152">
        <property type="entry name" value="CCDC53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="25704" checksum="EED5662007DA73B9" modified="2024-05-29" version="1">MAQENETVAKYTKMLKMGLPSGAVQQKMLQAGVAPSVIDAVMESGASSIRVERSDEDEESQVIESYKKMLKMGLLSGAVQQKMLQAGVAPSVIDAMMRSTVGNSSAEFTAVAPASFAAEQTVDDEKPTPIYGNDTVSESESEGDTKVDMANIADLDYDTLVKQITAKEQKILTFWFWSKRYKDKRAVLQNEIDAYWQELTGRNEYDDDDKEQWIARKENGTTPTLWKTTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWK1</accession>
    <name>A0AAD2PWK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="127"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="397" mass="45803" checksum="CA503F27097605DE" modified="2024-05-29" version="1">MVRGDSLQTLAGYNNAKKSFRRGGHDGILTEPKKIFAMFVLLVILAITESMRSTVAVLYHNHHPQDLGSAAEEAKPIIRKQQCPVGIFNNDTKHMDVNPECHPNSQKLLSMERVPTTKKITFMLIYYNDHHHLAHQLQSWKNFSQMALDQMQFLIVDDGSAPGHTAKEFLQANYEYAESMDIVIYGIEQDLTWNIGGARNLGFWMANTEWIFMSDGDIQVSRETMDYVVSLTNQKVDNFPGNETDPATQYVMNVFVMFQRYRPSGFKPHPAVMLLPKASYWYVGGCDEDFVGSYGYTDPHFRYKVEVDPTLHLINAYPDMDEQKVPPLVEMADDIGCPKEVQCLPAYSGFKPPREITKNQKKFFAKRDKGLWSHKVFRYTWHYVSWKKSWWSWLVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX14</accession>
    <name>A0AAD2PX14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dephospho-CoA kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042113851" description="Dephospho-CoA kinase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1964259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38136" checksum="CED85DA7665925E7" modified="2024-05-29" version="1">MVVFLVGKLLIQWLLASLSCVPLSEKGKGDYYYGFSWLLQSYGMFCPSDFESIGTLLSPDAMAILFSLRLVFVCLGVHLGESMCFVALTGGIACGKSSVSGILVGSQSSDNYQDGTVGLICADTIAHQILLPPSVLESYSVEGSNPTTVIACVVKPKESVFFELVAAFEGHDILSPNGTIDRTKMGSIVFRDGEKRRGLNRITHPKIFSILMSRLVHQALFSNNDLVVADVPLLFESGKLSWLFAITICVVTDPVTQFHRLQLRNPELSPKECEDRINSQLNLDLKMKLSDIVIDNSGSLDELKDKVEDVRRDIMRRLFGIGLSLLQVLLLIGGSTSIAISSKFFSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAK3</accession>
    <name>A0AAD2CAK3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1888596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042118940" description="Pseudouridine synthase RsuA/RluA-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="43"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1888596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="289" mass="33339" checksum="3D01378DCE5D8630" modified="2024-05-29" version="1">MTSVTLLLLLITALWLNVNSLSSPTNAQPKRQRIPVLQYHNSWVCVDKPCGLTVHRSKGTPKHVKVLTTSVKRQLARKVFPVHRLDHRTSGAMLLAFDSETAGKLHDAAIRKGHKQYLALVRGEWNREESSVLVDKPLRVKGTIKDAMTKFTLLATTKGREDDRCSLLLCEPLTGRTHQIRRHAFDIGHPIIGDSQHGSSRCNRYWRENKEWNRLALHCWKLDFEFDGEQRECIAPISFQLKKILNEMELWDEIIAIEPRLSMEPFDIKGGTHGRHFRKRRDEEDSDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD07</accession>
    <name>A0AAD2CD07_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1917733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="934"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1917733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1279" mass="137203" checksum="91C6E95F25902367" modified="2024-05-29" version="1">MGKTSLPTSRDSIHSASSQETTGEDSCRQRSIDGSMAVESKPQTGVSRTETNQDIKTANTESSSVSAAADPARNHQHGKASESSLDSIVNEANQGHEQLLTPTVVVDMPSEKPRTNQTLSEQRSVTPSDFSNAGSATLTNSASPNPQTIVQQHLEKPPPAPKIQQNQNPPQSTVGQPEGLRPSPTAPAKSAPQHHGKPFSQQATQPDAQQPKERSGSRFTITPVTSAPQGPAQTPPIQHPQSRRPSLATSTASTQHSVQSAQQQYADASQSQSVPSTVTQTGQEQHQQQHQQQQQQHHQQHHQQQQHQQQQQYQQHQQPQQHHHQQHQQQQQQHHHQQHAQGNTIGSQHSNFSQLSQSQTSQDQQSQQEPVETLAPLPSTPASVPTRIQQPQAMKHRSISVPCAPQPYPGEVGRSQSGPDSQTTYYYQIPGVIPVQTIQKTSTRGGGQPQEQIIGTVGAIPLMKVQDGLRYVKKGRFKLFQQTAPAPAPAQAVVPGPPESVPAVVVTQPLVPPAPIVAATEEIVSPKLAQASSGAAPVATPSPAAQSQEPKAAGEQNATGANGNSTPLPETLDGSSVPTVTKKGRFLVSKVNNVRTMIPAQNVAVPGAPVEAVPPPQSLHLPTMMQPAVNQPQTQSVIAPVQHVAPPVVQTTMVQQVQQVQQTHFEAVPGSHQVQQVQQTHFEAVPGSAVPVGSNWTASPFFSLQSTAVITEPYAASPHPSQQQQNQQVQSHRMTPVPQGIPEANATTSQTHVTSNTQTSTPPQTPNMQLAASTSLTQESTRRSMQAKALPEIPKGTEKARMAPTVPKKKALARAGPHALDRGGKLSLGKLSYLLDQMKSEVTDADLLIRTLQTDLKLMRDKNKALEAKNRDLDKSLKEEKGLREKAEARNIELRKKMREANIMPGTNGQKPLDQTVDSSATSASAKTKADGVAITKAKAPKAAVAATGPKAPTASEAIASSNPKRDPTAAPPAAIAEKKCQPQPPVGENKVDRPATNGVSIPATQNPASSTISLGREQGKEQFKRAVANGWHARSNSLGNAGDAFLQQVTADFGNTSPAKPKGGAQHLSRMESVGAVNGAAPTPIPAAAKPVARGALKPPCVKAFDPLHQNQPATNITGDMVPVMIPTQVSLVNADSPVFQDPHDPAAYQQRTTGLQQQYEQNQFVQENNIVVPITFGMASTMDQANMENGMQHQDINQDLRNLQQQFMVLPQQQPIMVHQVPGGVQQVQNLIAGQMPQTFTSNGNTFPSYGQPMMQQQSEQQQPQLFYSIDSFDPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFB9</accession>
    <name>A0AAD2CFB9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1364" mass="149845" checksum="FD8243C1C7DBA695" modified="2024-05-29" version="1">MSIPQPHLSGDLRLALSVLYSLPTVSDFSIQKPNSKEAHEYLMQFQCRNIRRKLSSRSKSLKNKNESSEGVDILQSLEAGDLGSSWLACLTLLAAHRTSTNQQIEVNYAEALFAAQTMVHRLRRVKLSEAIDLEFESPQSIPPKHEMIMDMYMQWSTTANSAFPQVLKNYQPQSSDEEATKGELTVLSLTTILYYQTLSCNQDFGRIRPLLSSIASALACCCARLRYTTTSIPSEAPNTQPIVKMIINTLTMVHQVVASSTGTNPDHANQVYSTALFIAMASIPDAILAGSGSGGGAYGKMSMDPRCYTAVTTEVRTQGLSQVWESFMDMPSPSSDQLVLFLEMCESWAKYVPLPKEFVRRSVSLLEQAFTELATDHPNPHQVAAGRAALRYWIAIMEGGCWTVDEVLASSLIQKNEKSQNPNKKKQSSKSKKRQKEVIEERTSQNQYVLAQNEVHHRSEIACEVTMRTWHVFRPLLTRELSTISDVNDETQGDGPVGGIVACANSCLPYLVRQPVHTSESLQLFVSISDAVNEICSSAARSVRGFAAESLYMLHDVVMTVGFPTDNSNGINLQNVLVGHFYKCCMNLATQCGYPGGYFDDLRENNDEDIEMERNDVRDVLRGISGHSPGDTTCSPSGLNVALCVLEKLLEACAQPIIEVGAEGKHLFPESALHAFSALARPIYAIALYYQGSPSVELERPLKMAIEIMSSAGRCVIQAFAQPFHHDMLPLSRLYSLATASLSPAFSALSATKSFETGIVQVLEICFQASVLSIVHLPELSAPSTLRSSRFDVRGAMRSPGGEDHVGILALMRLATESPTLTRMILGSNPSMVADLCHLYKQLKQMEKERGKGVLHGKGVLPKSRRILLGVICHLENSTAGQSVSTAVLEDLFKSSVLDIANMSSIQQTQLTPEILFGICENVFDLASFSENMVQSLYNFRPDDTESPLNRCLTFLNQVGVAGFNAMVNPNTLSREFVIEWNRLRAALFMLIRSSGIPDLPTTAIDLVKTNIVTECNAVLHQCNMGPRSGSAVFNDEVISDEVVPAGLMLQTLGEALDKAMVSSIPVVSLTNTIRILYDSRVTVLQVITTDCPYPIEKGSFCDPRPTIAETWFLALNKLLKVLIAQGFFQSAEKASDLSQAVQQLLVESCVSIVILLLYPSISKTQNKRANDPGMSFDGAQTLAMMDFLHLYFSLGPSMLQGVSIELLANIPVDLTSIQHLGTDRDIAGISIIGAGLFRAAQGGLPPWAVECIPSVYSSFFSALNRDPAIFCNVFNMSIHIRLGNQNFGGVQASQLLGGKYFQSMGEKSKQTFISQATELATKDNPNGWRQLKALIKKVCGGKKKDTDFKQKPGYTRWDALDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFV6</accession>
    <name>A0AAD2CFV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E2F/DP family winged-helix DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS84</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1891971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000008">
        <property type="entry name" value="E2F transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="8">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1891971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="638" mass="69291" checksum="B291DDFB5977F4C7" modified="2024-05-29" version="1">MISPTKTRDSWSNELFSPTNVTISSDRSSCLSPKSVELSPVNLFSDHLLPTPPRSLDDKSAASIPYASHPRGSPVSARVGTPSSLSQQSRFDSSLGLLTKRFVDILKETPDNSLDLNRAASKLGVQKRRIYDITNVLEGIGLLVKQGKNHVSWNDNPPEAAEEAISQVTGTGEGEEIGSPPKIANTASVATTVEFEEMKKKLARLQEEERRVDRYLGYLKGQSEVFNGKRPPTGEHAPYLPQGVKNYPEQMYVRYQDVTSMPAYSSDNVIGIHCPTGTSLEVPDPHQGMKAGDRRYEMYLSSKDAEGEAGGKEGGAEPIGVYLVQPKADAQNSGSIRSRPGGFEGSAASPGRGLPPPAGEPDKHTSSSREAHRPQYGPPPGRPGEHPYAGYGGPPPRRPGEWGYGPGGPRPPYPGPERGQRKGPPMPYGHPGAQYMPYGDPNWGPPPHQSHGYLQPPPGYYPPPHIRPPHDPRHGGESSKDRRDRPGSNKASSDRPGSDSMARQFHPPPHDDEPSPPGANPSPFRPRQHHFQHEVGRTASAGGDHSRDQSFRPPSPGREDSLMNMPLQSPTGAFGFGTPPGAPSRMDVRSGGMQFPIPNFPTERIEFGDRWRPPLSKSSDTPPQEDSSHARGPPRPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG37</accession>
    <name>A0AAD2CG37_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000168">
        <property type="protein sequence ID" value="CAJ1931628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1931628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="335" mass="37227" checksum="FED58E5DE3365DCA" modified="2024-05-29" version="1">MQGNNNTGNNDVPADVRPYDILCGRSKTCFNNIGNRRFRITISMNLKKYDSLPNRTERGKFIFTLAQTLQEDAGFRFVRISKKNGRVELTNEEIRAKIGHALRDLSKAQAEATVAAAKPAEEAKKFMSSTAASRTTSPTTTKEPSAAACNKKVAVITPQLPQRQVYVAGAADVDDIRKEMMMVVDSSSSSRHISVEPSASSHQQQQQHQVITSSLIIEDDEISEMTQDIPITLPQHEMMMMLPDCCGEAHNKLQPMKVQALKPAPIHTKVAAEVIGDDHYCLMPLQFDEKLNKNQILLEPASKSTFDDDDNNLFIVDSGSNSSFEGEFLRRCSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGS8</accession>
    <name>A0AAD2CGS8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000294">
        <property type="protein sequence ID" value="CAJ1933713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="71" mass="7981" checksum="0FB0621E9BA5107F" modified="2024-05-29" version="1" fragment="single">PPGSVNHQRCFNRLRPMVNFCTRGHHLGALAKEFLDNNIEPPEECRPIEEDPEPPSDMIDEATRLLAGTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ00</accession>
    <name>A0AAD2CJ00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000465">
        <property type="protein sequence ID" value="CAJ1935382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="507" mass="55995" checksum="96CF0837BA212475" modified="2024-05-29" version="1" fragment="single">MDVIKNPGVNLYQGKDQPNKGKGKGKRKPKDGKKAACYVYGNEDHMSPKCPDRLLPKTQWKNQDQYVDYGKKLNLNQTGATVPATVPAIVPGASASTSGASSVAGSVNTPLRLAGTTGNQMMQVPSGMQLMQIPTQGDSTVTVPYSMNANGEIAFSGMQLSRQGFSGVQVRQGFDATQAQTPQALKTVYFDTSNVFHDAIKGKDENGIDVYLIPCPAGTTNVKLQANWHYASEDEDLPDIATEADRGLQFIQSRRKERDPFGLYDRKMRFVNCKCVYVLEQLGANVKPGAKETSAMYCCQLSNFNNQPHFELSSNKQNGYAGLEMTSKMATVQKNKEGFTPRQVKAAMEARSAMHILNAASTKSLKYAIRSGLIKNYPITEEAINHAEAIFGPDTSTLKGKSTRPTPKKTYDDFFSPPEELYQQNRSITVCIDHVEIKNAKFLTCIDTTVCYRSCIPVQNLKTDLVFEALDKIFRRYNKAGFQVKIIKCDRAFIPLTDDVLDDMGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK07</accession>
    <name>A0AAD2CK07_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="223" mass="26047" checksum="872DF986A0A136E8" modified="2024-05-29" version="1">MGVMACPKAVASCLASFVKQYWVFIRYLWSLMKRRSMSREDFQVSLALYVLYPALLWLFLNVFHGLCGLETYDNKVEAIQACKSLYFWFCFLMRSYKLAIIHVYGIEKQGSDRNLGRGLRRSTANDEGISPARLKCQTWFHLSQEMTLVGWVVFLLLICLPVLAFWSMFLSILVTVFNILVLIRRLWITAQRREDAANMARDEEADDEFQEFLSNFTDEDPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK12</accession>
    <name>A0AAD2CK12_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000591">
        <property type="protein sequence ID" value="CAJ1937023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK12"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042045710" description="SET domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="225"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1937023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="496" mass="55701" checksum="A19FFAFF0EA26C5C" modified="2024-05-29" version="1">MSRQSHCLQSSLWAPTQLILLSGLLFSSSTAFSWNQRQSNLGPSRQTGTKYTSTRSYSRAVGHSNSPWASTSSSTNTINSALSSTAAAYSDYVSIDRSAPREIDYFQGWAGSCGVQPENGFYLQGQLVDDNEDYYAATSSGAASGSRMLYVPGEMILSAYQISQEYNGYIDASLQTLVEMDMQHLQKHFHLFLKILVEFEKGSESPYMPWLNAMPRKWNTAASMDNFCLSVLPPYIKAVCHTERDQLGAFRRALGAFDYVSPETKNNSELLKFAYNVVFTRAWRSDEGDYRIVPVADMINHEYPDNCVICYNENGGCEVYAKRDISAGEALTMSYGTPTNPSKLLATYGFLHQPPATFCKIVVSNPSEELKSVGYDPNRMVFFSDGSIAQDVWDVLLYHRLERKPELAAVKDAFFQAHMSGDEQTKNSIHNQFQRETVGALLRHVNHILAEVAELTYKMNSFDSSQHPRLPLLLKHHAMVTDTFTKVRDFLMDLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLC3</accession>
    <name>A0AAD2CLC3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1916622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1916622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="106" mass="11587" checksum="B7BC38A10F509F3B" modified="2024-05-29" version="1">MGRGALLKYADTCFENQESFMNAAIGDARKSEIKAVFASLAEKAGALDDSFTKDMFLAELDNCENTVKPAFTEHKIALGHSVYDTPIHVIDEKLVPSTESTWGADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLS7</accession>
    <name>A0AAD2CLS7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLS7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="542" mass="61573" checksum="87416FFC205206D6" modified="2024-05-29" version="1">MTDKRILTLGACTAIAVTASRFVSIKRVLSSLRPKNVQFLTIDDKEFVETNQEYDANDFKYHVLMPFIPGAFTSSDSYLPFLREIQIRCAKLGIRLDIAFGSFFFEVPNEAENDHILEAILKSAKEKGIKYDAKFLTGHSMGGYLAIEKAVTMTYDALIQIGCSMGSIWGVKDHRSLASYPQPVLTLVGEMDGFLRGLKLMHDMDTLDEEISREGIADDALLQKKRNKMDIVKPIIIHKEVNHLQAADNTVTEFQLKSGRHDFESALTPEEARERMAETISNFVLIVVSRTQTGLSDKSAYVSATEKQLKQSQDTREMLRPFRELSSTSSTSQFVMEAQRSIANLVQDIDITPTFHNSDEDFLYAKPFHSLAVAEKDTTLTTNIEVVAQDPILLDPKLPEATRQESPSFAIKAKSQDTFLQLSSSITKKEDPVSLRELNMLTMAKVLKEYVTQEQRVKYELHGRKLEFLEDLEIKVPPEWVKTPIQLTHEGNTTFVRSPFTRTSTAEFMPLKFRGMHYIKPMSPAQIYEWIVYDAFRHIPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM22</accession>
    <name>A0AAD2CM22_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS3898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000336">
        <property type="protein sequence ID" value="CAJ1934558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF378">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1934558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="81764" checksum="A1B118C3AAAFFFAF" modified="2024-05-29" version="1">MVKPSVPSKNIRRYSKIRTAVFLCILALFIYGLDNHVSGVNQFQLLIDDTSEQRTTAGHGDIAPSEQDRQAREILNSRVESKSEEEVDVRQDRADSSRDEEIIAPTPPESKAERTESAGAATTPPPSVKESPSPLPSKSAVSGYLMYVLTLQGVEGADDSNAQRFDNFKRHWSILCNNTQQAIEEHQQVVAEEIHFHKCPGYLNPMGAKFGYGLTMAYKECFDWALEHHKKWHTEHNTISNKNRDIPYIFLEDDARLYNSNFCHSEYRNRLWDAAPSDMTVLMLGGHNLFLQDQPGAEVERTDGVGQTGNDGIIPTFRRPNQSAGSYGFVVPNAERVAYMRRKVIKMLNRTFTPEGMVDFFGIDKQFYQYPMLKVYVTQPWLVYHEGGLWSNNKDRVRGEYGQGSGQYRWVPGLTGSFRNCSMDGNEANKLHNGPALSATPERGHWYAEGSVVVSCQPLTIRIPHQSLVMLQTSTTPDRLIAGVVSHSTRSSWRSVIRSTWGKPDGFVSNEKKGTTTNHTQVKVYFLVTGPWEEVASEFREHQDLVWIDQGTIATTMESSLASLQVASFIKLVDDYASDLYSYLLRVPDDAYANLPGIQAQLVEHQDNHTGMWGTNCRTGFRPFHIGIPETQYSDYFFPEYCKGKAYALSQPFVRCAAAHIADTRIVSLDDTYIGLLGERCGLQESQFLSSSGRVKGDERLLKLNFTQEGAMRRRHAQQQLFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNA8</accession>
    <name>A0AAD2CNA8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000757">
        <property type="protein sequence ID" value="CAJ1938697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="733" mass="81344" checksum="25528C3E33ED8CB4" modified="2024-05-29" version="1">MDIDESSLHTTSQTPPQVYFIYFGQAKEDIPRNITHVTIDPSVSKIHDYAFQDCHLLASVQFHDHLQEIGDSAFQRCRSLTLAAGGRGGLIPSTVKVIGQLAFSECSRLQDNLVLPHGLRSIRFLSFAWCESLTQISIPKTVENIDMEAMIGCSALLEVQLEKGLLSIGSHAFSNCVSLTTMTLPSSLTTLGEGAFNYSLALTEIKLSQALQAIEHNTFSWCRSLLEISIPNSVQTLGNGAFFNCTSLRDAFLCEGLISIQRRAFHTCTSLRKVHVPSTVSFIGDDAFYKCQSLTDVRLPQYLASIGDKVFWNCAALRSIEIPETVGRIGDEAFFFCTSLVDVSFPVGVRTIGTRAFGNCEALSAISLPSSLTMIAPRAFAMCSSLLCVEFPADGMERVTIGEFCFDGCNSLVTLSMPPSSVWESTSLMTCAALMDLRFGLESDLLQKQMEQKLQSLRGRFDNLPVHLVCYHSSRTTVQDVERVLDGIGNIFDDSEQHYDNWKDSYGLTPFHILATSVKPSVEMLSCLLDHCPDNTVQCLTPTDNQGLTMMDYLLLHTSDAVFPLIQVVLNRLLVHEMSKWGLERWSMEVSFCVNVDSNSAGSHDNETKLANVKRVLVLLGYYLRVEMTSLAELAVWKKNIQEVSSSSSSSSQLELLHQSDDDDDDDDDDEVVEEHRSSCRWQSGVEVVLQNVIGFLWEKNQEEPRATCPETAVSIYPLLSLQKMEDAMAGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP37</accession>
    <name>A0AAD2CP37_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="68689" checksum="3E01F619F579E570" modified="2024-05-29" version="1">MADETNDTPFVYTVQPKNEIPRGINYVIVDPSVRIIHNNSFEECLNLCSLTLPKSLRVIGKRAFERCSSLEYVYIHDGLQVIGREAFRDCSSLIHIRFPAQGLTTIRKGVLDGCGLLQSLSIPSTVEKIGQNAFHDCISLKKVTLRDGIRSIGSGSFWKCESMKEFQFPETLESIEAEAFVWCKFQAISLPASVKTIGTKAFSGCAALTTVKLQEGLQYIGRYSFCSCDLLVDIDLPTGLTAIDNRAFLMCTSLRTISIPGTVERIGDGAFASCTSLTDVEIQNGVRAIGHESFIRCTQLSGIVLPLSLDEIGANAFFNCISLQGVEIPSKSKITIGKKCFAGCKNLINLSIPDATRFATEDAFSRCDLLQTFDAIWSIRERFEQFPVHNACYQASSKSIDHLTQALDDSCQSLKGYMEDPFGMTAFHIVATSPNPRIDFLDCVLDRYPLDALSHNDAHGKTMMYYMLKHTSNKVIPLIKIVVHRAVIERIAGWGAPESWRADLVRQVESIHGDDPMGRNNSVYNFFDHTRHYARVEMTSFLELALWKMRMRQGYKKETEKVESYREICRYQCGADVVVENVAGFLWNGQPKSYAGMAVFAPHSELSFWIPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPE3</accession>
    <name>A0AAD2CPE3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001090">
        <property type="protein sequence ID" value="CAJ1941850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPE3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="390" mass="45406" checksum="31EE1496532C19A8" modified="2024-05-29" version="1">MIRTRKRSSQKADRTTADTVKNVALILMIALNIFDRNSDFLSNFHRQLSEANGEVVVADQTSASSKQQQNSIYLPSRLENRIMERSQSELQYDQLRADECDLFHNKSRSDFYQEYHDYLKTLDDYTEAVKTYDVNLGDVRLVPREKRHSICQSMDDLLKGSFQVDTVLSKTREGFVEPLLPPLRHPRFCEAVDDVYKSKYVMKLDYLIHDFGAMCRQLSTSSKTVFIDLGASLDIHPEENPSLQLLELYQKFGIKFDHYYAFEATVIPPDQVYQKVPKKILPSFHWFNVPVEVNETSNQNPWNAVLSQYTEDDLVVVKLDIDTASVEIPLVDQLVEEKNVRIVDQFYFEHHVRMKHMLKFWRITARGTLQHSLDLFTKLRKAGIAAHSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPQ0</accession>
    <name>A0AAD2CPQ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000875">
        <property type="protein sequence ID" value="CAJ1939924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="224" mass="25677" checksum="FA89BF632ECF92B1" modified="2024-05-29" version="1">MPNWLNISSPLLISTQSRRKQPKTSGHCKFLQCKFHCRTLSRSLVLTNLRKKQNNNQFFDGDKSDPRLCLENPFVGFWLLICSEMFDYPWATTFDDDYYNEPPSSIIRGIKQKRLAPFQSFFRPESSNHHIQHAIQKISDPMNDHLDNAIGPSHLNKTTLVDQRKRHCNLTDNRYDTLVDDDGSSGENADNAKAADDDATTIDGDAYQQPNQDDDENEILATEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQI1</accession>
    <name>A0AAD2CQI1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001101">
        <property type="protein sequence ID" value="CAJ1941895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="196" mass="22215" checksum="A4DE3405588C584C" modified="2024-05-29" version="1">MHLIMLYHEAYTASPASGEKLHRLIKEPSIQERTGSSIFIFSFTRDSNTWRLQALPNIAASISGLVRKLSFLEYSKLSIKIYFRFSSARKHSLQAMRAAQCPAFRLPKNTGKRLTGWLVRARVMALLNKKSKIVLFRNCNVVTQINGIGSVRARLKVLSRFLHDAFYLPLPAPICCVFQFLVFLSQPVPNACVLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQZ7</accession>
    <name>A0AAD2CQZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS8533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1007"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1074"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1155"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1191"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="894"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="956"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1225"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1293"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1419"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1463"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1630"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="919"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1293"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1313"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1336"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1365"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1499"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1575"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1597"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1607"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1639"/>
            <end position="1650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1943621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1893" mass="213166" checksum="7204439AAC71457E" modified="2024-05-29" version="1">MPLFRKSKKPVDKGLSDLPEEVDENYETNNPAALSPEEKEEEEARLRGTRQKMRNSKDNNRSPSTRLQEAEIRRNQMKLARQIPEDNNNAEEEENEDAAKIETLLGVTETGCCKKHTMFLIRSGSVEKSNRFETILDCKLCRQDSMQVQQEKKDQLYRFVDAATGQVKQFFKNPTKMKWKDKKNQGTYKSDEGDIDGAWKEQASLRLDQVLTWDIDNGPLKSNPQYAKYFRMIKDGSDVRAVREICKKDGMNPRVLDFDPFLPLEQQLNESTVLSQTTKDEIRLSALGEGTTPEELYEAVNNLHKLYVKKYNKEIASRPPPTPRGISPTKSLVNSIASSFAIRPTTVKKEAAPITELPSSSSAANNSMQPNSMATPVIATPVKATPVQNKSSSGKPIKKATPKMPMDEKEFLREKEMQEIRELHQDQREAKERRREKRKVDKLTGLVKGKNQKRNLKLLRAMEQLELTKDQLLGVRLKVDEKNAQGTDLIAQIQMLQIQFDERTKYQKALSTRVNDLRKERGMPPRQARRMPPRRVESTDDTSTGSYDGFGEYSPRQKSDRSLGSSVPIPLAPGDYDDKMISISDKLRADDDDEENENDTPRTRKRKSARSGRRRRKSNTTVASKRSVASKRREPNFDPEFLIEKFQEAIRKLITINRFFQQANDLAMAKESNVDQKSFGMRKSVLTDLVLPDFNEDEEWEYYDVEIEEDEDFDEDEFDGDESTVDSLGPLPSFGRNSLQSMPLFSPAGKNGRKSLVLKRSPSVASIPAPPPVNPDSKVRWNDDKLYTVRVIPRLPEDEDLFYTTDEIKLFRFEKFMDDNADEFEVVDDEEWEEEEIIEDDDYSIESFDDESYYSQDESVKSGRSFRRSSDGAFASNKKGWSYDESMFEIKPLEAAAPASTNENEAKPIESKPASVDTIFRERSPNTEDKTDLTSQASANILDDLIDQVDALIKRKTSEFEPTPSMAKESATASRGLPEMNIKSDQQAPDEDPASEPNESLAALADDEIQELRRTFHAFDTNGSGYIEHDELKANLKTVGYNINEEGIDNLLSMVDSKDGRLNFEEFIAWNRVLWKDDMNEKFKAIDAKNRGYIDQSQLKAYVVDLGHGFTDEELEELCYEMDPEGNDRILLDGFINVMAASRAGNSYCVVNGELYIEKLKTDFQSMDTDDTGYITRENLQEMATQSDYILSEKELDETMKELDLDGNGQISIDEFIAASVRIKDPSAAEEPDQSSSSDGFASGKGGIHRLSESRMSLLDEGKGGLETVLESKQEHQATEAEKYRQMIARLEAREKSSKSEAGDDEETPKASPKSSIASTSETEAGDDEEIPKASPKSSIASTSENTENSVHSKVAATGAKEKNTLSNFFGRTSQNQQAIRQGSKSSLSYIDQKRTVEMNKSNEVSLADLSVLTSDVFGSDSYSVLPSPDVKEQQQTESTKVAPGTEAFKNIVDNVRTKIGALAAEDTPSEADGNETKKTEEVFVPPANTRMSSITVDETLKNLDDTPDKTEERKTASAPAPEPAAKIPDIFKERAKAPAPAPVVPNAFKKKSQFLRESDSKMPKKKAILKRESTGGSKSSMSMDDWSSDGGGDETDTPRSSRRQESQNNDPNNASLPLIIMGDKLEADKEAGVDGIAPKKRRRKRRTSKKKPEREPNLDPQFLRDTFKQRIRKLISLNRFFQQATDAKFDKEMGTDRKSFATTGSGLSLLNKLSASDITEMDELYDSDDSDGETDEVGSMVSFGLSGVTNAANAHAGGRGLNRELSTMSMQSTTCFIPPAISAQPKRSSVMTQERKEARAGINVGFKPESKMLKVKLVPFLTDEQTQEFFWTEQELKLFRFEKFMEDNSNEFALVDDDEVEYEEEEFEEVSWVSGDVSYDEVSYEEETIAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTI2</accession>
    <name>A0AAD2CTI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042294950" evidence="3">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="296" mass="30754" checksum="9A6E8AB2AA157D66" modified="2024-05-29" version="1">MKITCAILPLALAWNQASAFSPSKVSSRPTTLPLRMADEFADEIPEGAVRATIPISEIVTPAAEAEAEVAKEEETPTSSPATASSASAAAKEEPAGALVAITQENIEFSAGVIGAVLGLVLGGPYLAAIAAAAANFASKSEGNVVGTVSKSGIEVYNSLLGLNAKYEVSDKAGKSLNDAVAKLKTSESVDPETFEKVEKALSQTKTKITEVNDEYDLVGAGLTALGVVGDLIEKTVKKAGELNEQYELSSKAKDALDASISKAGVSESLEQATSFLDEKKEELNDKLKEVESTSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU99</accession>
    <name>A0AAD2CU99_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001496">
        <property type="protein sequence ID" value="CAJ1945767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="127" mass="13832" checksum="7D67197794E91B08" modified="2024-05-29" version="1" fragment="single">MSTALDNYFAALKLEVGVSNFAVVQDRAIQRTRRPAPERNNPQQALRRDALTRTSAAKFAIDECDEPLHCPSRQMSSDFSSQSFSADDLEVLVNLSSGSVEALGVIIDDSCRTPSVSKDNVALEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUC3</accession>
    <name>A0AAD2CUC3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001558">
        <property type="protein sequence ID" value="CAJ1946070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="246" mass="28831" checksum="ED9EFC473E9EB52C" modified="2024-05-29" version="1">MKKRLEIDLELPKDRDPVSSNDVDVKQLAKDQDALQIANKMEAQRIAERDARRGDHYDKLVPKLSEWWMKQLYSGEAVNQALQRMDRIQTGNPLFAAWDERYPGAWNQPCLRYDALFNDFMGTSTCYERFIQIFHYLNSDNTQLAQYLISSFDLSTIEDKVAEDVWSLQVLAIQISLQNPFSFFGIEEFEEKLHNNQFFDGAKSDPRLRLKNPLIGFWLICSELFDYPWATTFDDNYYNDPPSSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUM1</accession>
    <name>A0AAD2CUM1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="493" mass="56078" checksum="223ABD4F33D48688" modified="2024-05-29" version="1">MRVFILYSDSQGKLVEPICGSSGIPENAVTMEILCRRFFDRNENYYINGFSYDCQVFLNILKDHTKRMQNITLDLIEATMGPEYLALLIATFNKTNSLTLVDLMGDAGYTCLKSCFLQQDGPREIQFYPVKRISIDHARLLFEGLALSSTIESFVLSPPSGNLIFVDPDDAGHAFVAALGQNRSLKHIQLHSDHFQAVLRWQTFPEIFKTAILDTKVQSMDVRQASLVGQARISFETFQETLCQRDCSLEKLRMTAVAFWPPDDDVLMDDNDDAASEDSIIPNTSIKEFSLNEIGLDSPRIMETVSLLHSLVSLDLRGNSISTLSPLDPLLIGEYLTLQCLNLDENWIGEAEAVGFLRKLPQMTCLRHLSMSSNPFCWTRSYMEVLADVVWRNKSLEDIRFEVNDLCPELAAMYSQISVPLSWNRGGRRALMQVESSSTGTLPPNLWPMVLERATRICYYEYGDEWHKPSWESTQPDVVYWLLQKKILGEWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV77</accession>
    <name>A0AAD2CV77_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS10389</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057570">
        <property type="entry name" value="NOL9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25467">
        <property type="entry name" value="NOL9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="10">
        <location>
            <begin position="204"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="NOL9 C-terminal" evidence="11">
        <location>
            <begin position="433"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1946248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="570" mass="62996" checksum="8A51A0E072955165" modified="2024-05-29" version="1">MKNDQNMSLPEEESSSDPPEVDSQDDRGQKRPLEEEDAENDEEDKKDKEHELPRNILIEWNGQNALVEIDCRGDNDLENRICIVGRGTIQCLQGSLHILGYTMQKEENVDTGAEVILTSPFWSSWTTIQATTPMVRFQVSSLRGTPSFRFASASRRPTILPASWITTADTIVSACQKEPAPQRDSLEDDGIFVHAKPQIIFICGGKGVGKSTFLRYLTNRLLSVSSHEEVAILDADVGQPELVPPGILSCTIQKTPLLQPPYWNLTESRENVASVFYGAVSSKDDPSRYIEAIQYLVQAYRDHLKSTLNPTPLLINMDGWIKGLGYEILTSLALSIAPTHVCQILGSSKAKTFDLQRTLSGRESTIYFLDACTNLISMSCSIPSFTLRSLRLGAYFGPNLEDLWDTLDFTPAKQLQVGWIDDGCILAEYLAQERPYCVPFETVQCSFLSPDHDDLMADEKRVLQAMNGAMVGLCVGNANNCLGLGLVRSIDWQSELLYVLTPVESSFLPQVDMLVGGNLPLPLSFVLRGVHAESFPYQSMTNASVVTALGVDPMKSRNNIGRKGSMNGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWT0</accession>
    <name>A0AAD2CWT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS9764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="3122"/>
            <end position="3188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="953"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2001"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2644"/>
            <end position="2667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3194"/>
            <end position="3220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3546"/>
            <end position="3601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4357"/>
            <end position="4380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4582"/>
            <end position="4602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4808"/>
            <end position="4839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2017"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3570"/>
            <end position="3585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3587"/>
            <end position="3599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="4357"/>
            <end position="4368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1945620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="5501" mass="614934" checksum="FBE2F2C330D7CC78" modified="2024-05-29" version="1">[encoded data, 5501 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWT1</accession>
    <name>A0AAD2CWT1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWT1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="72"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="203" mass="21106" checksum="5FD413D6EE6D100B" modified="2024-05-29" version="1">MMSDPATDTPENAQKPAETPEADAPTPASSEAGDKDEAPKEPDAEKPKEGATAPVVSSSKRSRPPYKYDPNKITLRFLFANRDGLTVTVECNPTDCIGEVKGALLSVWPEDLPSCSGGDRLRLICMGKGILMPDSRTLEDCEVPVFKTHPTPINVAVRPENMGASSSKGGGDKKIRLGGAAAASSSGGPSGNQAGTGCGCFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FED4</accession>
    <name>A0AAD2FED4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000428">
        <property type="protein sequence ID" value="CAJ1934970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FED4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="209" mass="22669" checksum="37912509FBB125E5" modified="2024-05-29" version="1">MKANIINPPEKDPNLSTTVADHGQGGLEAKTRSNSTTQLSIALTKDNPAITTPKRSSKRYPSETAEDGAMKGRSLFPSEVAQGQDVPLVNTRRNPTTPSSIDLTKDNPPDPTTSKSQRKQPPPSKTAEDGAVQGRSLVAYITKLKVSQFCRLYTKVWRQEVFALATAQRVITTKVASLLGFFACVRPDINCSTRRAVDLDVASGIQILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEG1</accession>
    <name>A0AAD2FEG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000441">
        <property type="protein sequence ID" value="CAJ1935015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="53789" checksum="FA2D2F3F96E9A062" modified="2024-05-29" version="1">MSGLNLSQVPKKPREWPSSRSGSSANKNKNRVATRRKHREREMKPLKDKLKSGICTKEGSRSTKDSKAILEAQHNLCFQHIGNEMKADYEEHDAILIARCMIQIKAKFDTDEGLNFIQQYYINQGLKKFGDDGKDAVDKELRQMLLRDCFTPTFVKDMTASEQKKAQSAMMLLAEKQFKKTIKGRLVYRCDGTHEWLSREDTASPTALQEAITTTCVIDAHKGRDIMTMDVPNAFIQTYVPEAKEGEDRIYMKITGMMVQILIDMAPEYREYVVLENGKQVIYVRVLRAIYGMLQSSLLFYNQFQSDLEAKGFVFNPYDPCVANKVVDEKQQTIRFHVDDLMSSHMDPKVNDEFAKWLNMRYGLIKACTIVRGKIHRYLGMTLDFSVKGKLLKIRMDDYVKNMLEDFPIKFNKDSKQETPAGNDLLEAGKGKLLNAEYRQIFHTTVARGLYVSKRARLDIHPTITILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFK7</accession>
    <name>A0AAD2FFK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit beta</fullName>
            <ecNumber evidence="13">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS750</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="13"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1916464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF82">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="168"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1916464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="500" mass="53456" checksum="5523AE9E15093877" modified="2024-05-29" version="1">MIAARRLAQQGTRAYSSTAAAFGTGKVTQVIGAVVDVQFDEKLPKILNALEVEVAEGNERLVLEVAQHLGENTVRTIAMESTDGLVRGQKCADTGAPIQVPVGPETLGRIINVIGEPVDEKGPIFTDKKSEKFAPLHRAAPTFTEQGKSQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVVIMELINNIAMNHGGYSVFAGVGERTREGNDLYHEMIEGGVIKIDEKTGSTAGSKAALVYGQMNEPPGARARVALTGLAIAEYFRDEEGQDVLLFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGALQERITSTGKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRSIAELGIYPAVDPLDSTSRMLDPRVIGDEHYEVARSTQKLLQDYKSLQDIIAILGMDELSEDDKLTVSRARKVQKFMSQPFHVAEVFTGTAGKFVSLEDSIKGFKDIISGSYDNLPEGAFYMVGNIDDVKEKAATMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGG3</accession>
    <name>A0AAD2FGG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000746">
        <property type="protein sequence ID" value="CAJ1938638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGG3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32518" checksum="C8E66FD3970EEDCB" modified="2024-05-29" version="1">MDGAPVQIGRKTTFMDTICRCNIDHHISKPYTPKENPAEGGIRELKRRYYRLIIKHGIPERLWDFVLDYVVDTMNVTVNYSKYSDGRVPLEIITGITPEITEYLDFTIYGWVFFRSNGGLGVNHMGRWLGVSQRVGPMMTYWVLPKSGIPISVDTVQMVTNDEQQTDSVKQQMQRWTADVSKIVDAKSTYINWGKEDIPHQMMFDFDNEDDEFMRNFGMLINPETLEDGDFEGTEQAADDLDAQDYTNMEIGLRRGAEGKLQKAKVKRLIVDENGRPIGVANSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGQ2</accession>
    <name>A0AAD2FGQ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000662">
        <property type="protein sequence ID" value="CAJ1937536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGQ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="197" mass="22426" checksum="E4E93E7F9905AA15" modified="2024-05-29" version="1" fragment="single">MELLCKTTGMYRRQLSNLNNQPHFELSSNKQNGYAGLEMTSKMATVQKNKEGFTPRQVKAAMEARSAMHILNAPNTKSLKYAIRSGLIKNCPITKEAINHAEAIFGPDASTLKGRSTRPTPKKTYDDFFSPPEELYQHNRSITVCIDHMEIENAKFLTCIDTTVRYRSCIPVQNLKTDPVFEALDKIFRRYNKAGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI33</accession>
    <name>A0AAD2FI33_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="435" mass="50122" checksum="36BDDAD3A1A8D38B" modified="2024-05-29" version="1">MKVLYRNNIVQRMGGEFGFDFLVVTYCENILDDESLDHFYGNFDLNTLTCLQKELLLITFLEPYQETEPRKKRVSFRNDMMGLDRSIFPILEEHFVAALDDCFVTGLDYELCKAYFAELRPVFKECTTVSKYRSNIVERMGGEATFDLLVVSYCERLKGDIKLHRFFESYNLHNMTHLQKDLILMVLLQPSAENNVESIERRVTSKYSPMFALGLNEHHFEMMERHFSAALFECLSRPVVIQICLKLFSNLISFFEEHALSSVEFDDDDDDDDDADDEVEDDDDYDEVEDGDDKEDETLIVSTRSLQIGSKASRISYNEGVQSHIAKRISQALDASDRTEQTEQNESLESKGVRSSEFESERISSRATPEKNAKGRQNFEFISPLASENKTKRRTTIGFSTSSLVTPKKLNGKPKMAFGWRSPAFKRMKRSAMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FII2</accession>
    <name>A0AAD2FII2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LRRK2 ARM repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FII2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="809"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1942068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1145" mass="124953" checksum="3BA6ACD76E922210" modified="2024-05-29" version="1">MNKASTSITNNMQQQQQVSLNTAETEASSMQQIQRRVETPNPAESIEIDSSNGNRAFQGSSSSSSLESSLSSPPSNLRIAPESAQHEDEANMALHYGVKGHQMTGLLPSLSLGSRTNHHAASGRVHGSTTYQQARDPGGRNGQETKLAMMTTTQSTSLIARSKGSYGEDSGKAQASLTSEQKKHQQREPLNMSDGSGNSGNVVTTTTATNTSSGGDDPDSSWGNGMGAISMPQDESCSDVMRLHHLRHQARRRVLENDSSTLQLPRDDGSPSKILRGPSAVVASRLLPPNSDTTTNVSSSGSGGEVDPFKENLLKSHRESGYHPMRKRFNKLPSRHGEARHGPQTSATDSSSSLEGTIASRTKSPGSSSKAAKLKLTSKKTGSQRRDTAAIRFRDPSPSPDSEGSITEGGEGSSSGSGTEGGYAGSASSNSGQQESSCSSSPSVSSTEESQFRSMSRRHRSRKGLKPPKRSESIENYSSSSSSEIADFSSGASMLNEDNAVELSINDFDESVQSASPSLSLSNERDDLDDLEVTYLHAKRAVEEDQVKFIKATTKKRKAADVGTWSRKTPAEWPRPDVAVIDSESKLDRRPPILSLGSDVMAQVFTFLNPPDIMDVLSMPLSKDWRETVTLQPELWRTLCLAEPFKAKMEDYTDSDTNENSFVSLDRYRLLYTSFVRCMKYLSQIREDALNGREPTFIDYGGIAQRGRNSKRGPPLLLGSNRNLQLFLARARGAVEEAKSEGVVGVAKVSAGRTTPDKRSAAGSYPEDQIQRKKPKLAGRSMITDRLLGPSKAGDVGNLALPWSCAIYSIVNWMVAFLDVEGIQILCLKVLPFLLEDEKQRMTAQRTGLTDVILRAMILFDKSEQLHIAAFHTIVLLARPLGGKEGMLFHSSMLASGIFGSQTSQHRKNGIAVMLDSMRRFEDNEILQAMSCWALVNIALAPAQKAVLVKLGGIQVTLNAMSRHPFNAEVQFRALFALINLVIPSISLNRTNSDPMQDQLGETNNKTNEKEIIDGLVGKIGVLVVRAMTNLCSSEAILNRACLVLHNLSLTPGYHETLLWTPNCYQMLEWCLANYRTDQVLQQSASGTLNRLQTTLSNDISLRTRFADSLNAQHRRSLQQAHNEAVRINEQEEQLNGLVQINQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIN8</accession>
    <name>A0AAD2FIN8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIN8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010865">
        <property type="entry name" value="DUF1499"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34801">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34801:SF6">
        <property type="entry name" value="SLL1620 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07386">
        <property type="entry name" value="DUF1499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042091545" evidence="1">
        <location>
            <begin position="18"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="271" mass="29780" checksum="CE730E6DD200E084" modified="2024-05-29" version="1">MKLLELSFLILVAQTGAFSHSQFSQYTTTPLSLSTNDGDNDQQQPTQPLLYSRQSWFQAAAMASVMIAGPNMAFADEEITTSLTPPPPPSPALAAAKTKTIEKCSTSSKYPCVSTSNVKNLDLYLPPWTYDPSQYSSVEVLARIKGALMTDPTCQILPPANDEEAKYYLKAQVKRSDLFWTIDEVEFLVDEEKQVVFFRSLATSSDFNDFGTNKKRLEDIRKKAGIFGVMGESLNSADSVSDSERGYGPLGQLKAFYGLQSGGGFEDVLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJE7</accession>
    <name>A0AAD2FJE7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001211">
        <property type="protein sequence ID" value="CAJ1944140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="107" mass="12184" checksum="8696F5F2D3DBF684" modified="2024-05-29" version="1" fragment="single">MGKSINAKASSAMTKKSGVSKMKTTSVAKKSVKKRVEIDLQQPKDRDPIDSKMVSETQTEEKRVTDDNEAQRMADEIEAKRIAEREARRSGHYDSIVPNLSEWWMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK30</accession>
    <name>A0AAD2FK30_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000565">
        <property type="protein sequence ID" value="CAJ1936841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK30"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32106" checksum="8371BABE65EE67C3" modified="2024-05-29" version="1">MTLDFSVKGKLKIRMDDHVKNILEDFPVKFNKDSKQETPAGNDLLEAGKGKLLLNAEYRQIFHTTVARGLYVSKRACLDIHPTITILASRVREPTESDWKKCVRMMRYLFCTLLYHLTLSNESLRVMKWMINASFAVHPDFKSHTGGTLSFGGGGAQVTSKKQKLNSRSSTEAELIAVDNVVMMILWTKLFMEWQGYPIEKNILYQDNKSAILLEENGCKSAGKRSQAINIRYFFITDQVEKGNVKIKYCPTDDMIADFMTKPLQGEKFCKFRDLILGPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK38</accession>
    <name>A0AAD2FK38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001372">
        <property type="protein sequence ID" value="CAJ1945353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="269" mass="30065" checksum="8C170982A3357001" modified="2024-05-29" version="1">MAEPLYTAFTGDQAESNSIALLEGRYFLPALLDPATTAFLSHCQFHKDHLSVHLEVTTSDHVFFWSRNPEDKGSELHGLHNGHFKAAAQLPVIASYDALFRNIPLAMGFVPSNWQNLMNFAIEKKAGDLRLSKMHTIQLMNLEAQANNKKAGRAAMRYAEEHSLIPDGQCGSRKRHQAIDLALSKCLVWDLLILQRRAAGWISNDAKSCFDRIVHWVAIVAMLRFGLTWRVLSSMFNMLSSATHWLQTGFGDSESTLKPPSVIPFQGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKG6</accession>
    <name>A0AAD2FKG6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS5763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="64"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1937676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="348" mass="39007" checksum="50A94995A806C4C9" modified="2024-05-29" version="1">MKRKVLGGLNINVDLVNDEHSKAKRIAFDMNDTTYRHDGFSIGQDYLRLEGKTISRGDLLPKALVIDDLIGEGAFSQVHKGLWTTHKKKGTHEKQVPVAVKQFSVLDSSEQRHDMLLKEIRALCKVECKCLVQFFGAFLEKDVVTLVLEFMDRGSVEQLLKRKSNGLGENFVASLTFQMLWGLSYLHHEKIIHRDIKPGNVLIHSTGQIKLCDFGIVSLSEQTLSSTVVGTSRYMAPERLRAQPYGRSSDMWSAGLVILECITGKCRWGDCTSIVSLLMTVEEASPETMVPDSISSTKLKEMLHSCLNQDPGKRIPAKLLLKSPWFQKDHDIATLSDAIKVSKDSYPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKH8</accession>
    <name>A0AAD2FKH8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042077568" description="VWFD domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="1357"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="1680"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1854"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1971"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1977"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2012"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2025"/>
            <end position="2038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1937648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2296" mass="254682" checksum="1D4D101B623DB1C9" modified="2024-05-29" version="1">MKFSSTLLSLAAVAAFPSIANAASTPTCEEQSGCIQFSVNKLNSDSCGLGGECAVEVCMQVKNSFPGCAKDDTFSHMCMQSDSNGCPAWKDADKTIPLLGGVEDGGSCQSGKKYGEGSGAGDQIFLGKCEEKSDITMCQEGKPGQTLYWILKDGNEKNNPSEDKTFTLPFALNGADTGCTSDVRCWNDEYNCGATYKKAQAPKERTWAFTIPSSNGGSCDACGTPALPPTWTPFAERTVNGVFSNDVSPARLTAHMNANPDAIIHRHCPSCSKDSHKDIYYKRVTPVPDQAAFDADSGDATDFVDIFVKNWMSTPSNAINTDFKLYSSYEDAVEDANAWTYCNYDDDWVGFPRDCGPTGFTPGQWISIHSGTWTFEVTGEVPVLVEEPTVWTTFASKDATYSSNVSGASLTAHMNANADAIIHRNCPDCADSHKDIYYKRLTPVPDPATFDADSGKAKNFVDLFTDNWVDTPSNKLNVDFKLYSTYEDAALDNKGWSFCNYNSAGVGFPRDCGPTGNKGGQWINDENWSKKYTFRVTGEVSNLVDEPAEWTTFVSKDGTTISNSVSAARLTAHVNENGAIIRRICPTCQSKDHKEIYYKRITPVPNQDDFASAPKVFDFVDLFANAWTSSPNNEINVDFKLYSTYEDAVLDNSAWSYCNYDSSQVGFPRDCGPTGFAPNQWTTTRTWGKDFVFEVEGTVLFHELDTVWTEVASVTSGTFEQNEDVTAESLAAHVEQEGAIIHRSCPSCADTHKDIYYKRITPIPAQSDFDGATPDNFLDLFTENWFSTPSNKLDIDFKLYSSYDDAFLDVNAWTYCNYDNEHVGFPGDCGPTGSEADQWNSKSQTGKDYTLYAAGVIPLPAYNEWDVIASSAANVKNVEVDDAMLRQHLATTNGIIRRFCPGCSDPLHKEIYYKRITPLPEPSEFDGTTPEDFLDLFLNNWFDQPKNELNVDFELYSTYLDARTGENKWAYCNYNDATVGFPRDCGPQGKLGNGWISMSKHWTRDFSFEVEGNLEPVIQAASLSAIEEWTVVAEATHTTKTKYYASEAHVMKHVVDSTNGIIRRLCPSCAESHKEIYYRRLTSFPTVDEYKNSASAASSFMDMMINNWYSYPKNVLDTDFALFSTYEDALAGINAWNFCNYDNSGVGFPRDCGPNGFVASQWTSFERNTGRLFAFSVEGSVPPEPELAALADSEGWTGVARKSAGIPYQCLSDEEFRTQMEATNGIVRRLCPSCTNPTHREIYYRRITPIPDQSEFETSDAKNFLDLFLDNWMKEPSNELNIDFELYSTYEDARKGRSKWTYCNYDDSGVGFPRDCGPHSFTPSQWTSTSRRSQDFVFEVEGNFATDNECKPPPKACVATGWGDPHMITFDGLKYDAHAIGEVIMMMSQDSDLMVQARLEKVVGHGADPAATTGVAIRENPMADGTEYPLVQVSMTSGENPPLTLFNCPVELYIDQVKQEDLFAGYHSNDVKVEVHMNTGRIHIEYPDLQLNLKVLQFMDLCHFTVTYALLNDCRPEESIIGLLGSPDDDATNDWMKRDGTVVDLPSGGLSSFFFGPAYEYVTQNWCIYTENESLFTYQPGYNFTYYEHCGVDYNPELERSLEEATPEQLEKCGDGNTACLLEAVNLGEGAADQSLETPGADEEEPEEIKLLKTEASSIISDIVLEVPDTPPADGDCPVCRAVGWGDPHIITFDGVSYDVHVKGELTFLKSTDPENDFTIQARTVAVKNHPKGPAVTSGVLVHKTGQPTIQVSLGEDEGSELATGFTVSNNECPVQLFVDGEARDITTGTGLADATVQVKGNRIVVEYLDLQMRMDMSVRSWRDECHFSVTYFLADCPCDGSLVGILGQPDGEWSNDWHEPDGTPVDIPRSSRKRRGREAYDYSLTWCLGRDASHFTYEPDMSHGDFDLCTGIKGDDNYDVDVDEIIEEASPEVIEQCTTDNTLDEGCVIECVFLGEGACDEYVEIVQNTQTADIPDTPEETLEETPEDTPDLPDIDDTPDDTPEDDTDVGTSDNSNTSPTDTEGIPEDNDTPAEENDTPSGSLGDPHFRAWNNDHFEYHGQCDLMLAKDPDFADGLGIEVEIRTKLVRFWSYIKSAAIRIGDDILEVQGSADPEVGVTEYWMNLEYQGPIKTLGGFPVTVSARSQRKRSFVIDLSSKFPGEKIEISTFREFVKVDFIKSSEASFGNAVGMLGDKKTGKLLGRDGTEMDDFYALGAQWQVRPDENMLFHRAEDPQFPKACVIPEDPQGERRRRLDEQSVTVDQAEAACAALKNPLDRKDCVYDILATQDLDMVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL13</accession>
    <name>A0AAD2FL13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase UBR4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UBR4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025704">
        <property type="entry name" value="E3_Ub_ligase_UBR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045189">
        <property type="entry name" value="UBR4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13764">
        <property type="entry name" value="E3_UbLigase_R4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52043">
        <property type="entry name" value="UBR4_E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin ligase UBR4 C-terminal" evidence="3">
        <location>
            <begin position="696"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin ligase UBR4 C-terminal" evidence="3">
        <location>
            <begin position="930"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin ligase UBR4 C-terminal" evidence="3">
        <location>
            <begin position="1325"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="UBR4 E3 catalytic module" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1418"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1427"/>
            <end position="1440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1939099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1811" mass="198832" checksum="4848A1EE9D558BC6" modified="2024-05-29" version="1">MPRTVAGPSAATAASPGSPSTSNNHGNHGSHSSTHNGSTTRGPLSLPLLEGLRCRPGASDLCFNQAIRNYTSAHAIARFVQSKLNEKSGKASPKSKAQSRKRGRRRKSKEPKQKQQQSLPATLAKKQSYHWLIPCLQSPSLAERKAAFGVLCAGCPMERHALWQVLELLANLLQHRGKLATKIPILTLFQHIALECLNPQEQLALWIHPTMGLPWWSDWLWHLSIGLSETNHPCEQQHQADLMSLLMDLMHGIGTNHKLVIKKGDDEGTLPLKYLWKSKEQIKQGSQSKEDASPLAALIGSYHLCKTNPVLKAAIKESSFEHWKQLVDPAFVSGDAGSTSSSNSRPSLKKPERLMDTFADPAIDLAAVSAMLSSSSSTSSRLQGRNSSRLSSPSANSTSNSNAANSNSSFPFSRARRRLEDRSAAATVARIFNAVYGNQENEQEEDDEVSRFLNRNRRQSQETIVEDPPANEEDEGDEEGTKSEEEEEEDDEEIDSDEAEGMEEDRAGSDNEEGEEDEDSDDDDSDDDDDEEEEEEEAEELSVHGIEAEVLESGLLDFEDIVVDEDPHSLLRSAQRQSSASAASNRANPPPTANPRSLKQKRRVYVVAAMQVLKMQHPALKTLHQQNPPKVSASDARKQGLTVSAEHSLMSSIVNIVQPPKKPPNSKIILRRAPTQEEFFRGSLSKNPVSLSMLRSHENKNEPTIKDLRQHIANDLQMGDSAELLELLCANKILDTDLKLRVVHQVVWKDHLMQNSSSSGGSQSAAALSSFLGGVGRGGRSFISSGAGLSMLFGSGMERSLLGMPSSNSNVNADTPLSGLPPMILTYRLIGVDGEATEDTINTLQDPEAPSESATPEEVERMMEQKFGVTRTIMEGRGVFCLLKSIERNINATLLKIRRDDVTEIGVQARRNVKNPSREVFKSSSPYPGLELLWCCSKLPSNRKLLLQSRAPTMLLRLLLSVLHALEEDGKGGSVSESNATVKALQKSIEVLASDMISSQNDTAMSETEEDNEQDASTLRLLLTAIETSSLSRPLRNVIAKLLPYLTYGQASLCKELANEFMRHVSMDQLGVCETQPDVWDEESRYILPATCVHASCSLPENPVCDSLRVELVNCGFVERLAKVLLDNVPSQPPPWSPSLWTKDVEQSENEKIKLEGKWKEYFARPGLKTAFNMLIGLCKSHGKTQLFIGNVHMDLPGRKKQSLIQVCHWIESTSDSSRVSTHDLGIVAETLLDELTKEEKTVAPIVKSVRRKTRDRKKEIAMARRNKALRGMGSFGPSAMSGAKVGEKAPVRGTAASLLAPVLGLFGANDNDDGPPAKRAKKNPQPAPTAKPAWMTEMENMEDEDGLTCAVCQEGRTLQPAELLGLYAYVKKVSIPMHQSGSKSAIDGTDLLTSLPGSMPRSISDTHAALEWFPPAKKSGDELRSSARSSSLSSSSRKTTYTTTVTAGNAIHFSCHAKARQADKNHPKAPKSEWEGASLRNSRVKCNVMLPLVSSRSSKVPLVAVDSALTDHSTAVSNLLNARPKSMLWTVLHDVRLLLLRIAYGEPLNADCEGGSLSSNSRLVYYQLLMADMFAKDAEIDSPQTARHACSLSGGFLAACTMIKADDYDKRKQTVVNRSIADSSLMAALTCILFHNTTNDYNKSKKSDDNAPNNKRRWVTGKESFLRGLITCAGRRHSLGLEDSGCLPSRNQLNRGSFADWDVDEDDAAMDTDMSPSIHLRRATSGRAGIEDFRNALRPMIVFYAIMDQVSSDFSLNMDDAKVEECGDRLTQVIQDCRRATSIHDLLQKAKVTLDHADIMQELQRGILSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2024-10-02" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMI2</accession>
    <name>A0AAD2FMI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001513">
        <property type="protein sequence ID" value="CAJ1945790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="215" mass="24237" checksum="9F73341F9FA8AFFF" modified="2024-05-29" version="1">MVLLETHQAISENNPSSRSEMASLNKIIGTPVAISNKPCLCGYNSSSCGGGRMTSQLNNSSCKRKLQGASYFDDVLIQHEQELLHGVADDVDLDDNTFDDLLLELESHLHRMKKGIAYELAERQDPSYVSNWEFQLAFLQSSHFEPKASAAKLITFFKYKQDLFGEDSLVRDITVQDLNQDDLSCLLDGNIQFXXXXLRSIHFFQPWKTNGNEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMJ2</accession>
    <name>A0AAD2FMJ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10008</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="715" mass="81513" checksum="2147734009CC9059" modified="2024-05-29" version="1">MTNYITTFVNQESLKSISFPKLPRMSAITQQQQEQPVQETIITGLVCAVAIVLLRYMVLDTYRTYQRLCRQWNRRQPPVSILRRPEGGSRKKNRSWFGVFIRKPNRVRFAKIFRRTFVPNKHELQSRRECWGLIQWRIQLHDEVLPEIENTVRFVPHTPVSILRPSRQDWGSPKPTSSIRVHFAPKTRRRNFLPDEQDLQSRRQLVRQIDRKIKRRNARRWKIDFKRTVLATIVEDPAEEDLSNIDSSLDTGFIDGKVDSEIIAIALENHRQMLPTVLHDMLSNIPVPMDLDDDDNNNKPCMEEQAPLSLKRIATSCLISSRPTKRRKMNSSSTVPTCAATWAKRTNELFTPLLPVIIEDPEEDGDESHIESSLDAGFNDDIANEPSTRLAKVALENHRQMLPTVLHDMLSNIPVPMDLDDDDNNNKPCMEEQAPLSLKRIATSCLISSRPTKRRKMNSSSTVPTCAATWAKRTNELFTPLLPVIIEDPEEDGDESHIESSLDAGFNDDIANEPSTRLAKADAIWVNKSEEILAEKANLNKMTKAERAKWANKARARRSKGQKEIDFEPTLLVIIEDPIKEEEEDEVDDVNEKKEFKPSLHVIIEDPEGEDLSTIDESPLDAALINDDFDSLEDGSDGEIFAAPTEQSDNARTTDIPSDGMGSGWTESGKRYSRRLQLKLSPEKKDPSTEALGSDMTKKGRRYSRRVVNRGKGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMJ7</accession>
    <name>A0AAD2FMJ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS10144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042276579" description="Thioredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1946002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="236" mass="27072" checksum="3C7C063F97AE598E" modified="2024-05-29" version="1">MTIRQKSSNLQILVALLVLSCTLQATFGQNVHLLTTENFLSVTEGKNIFLKFYAPWCSKCRAMADDWERLGNDFKDHEHTIVGEVDCTSDTGKLLCEEYEVQTFPTLIYGDPMNADTYDGDKDYDSMSAFAQQKLSKPICSVSNQDHCTKEELKVIQSLLEMSKEDLEEVMTTVEDQVKAAEDDFDEQVAKIQQAYDALVLKFNDKLDSLKDAYNYRYMEQVLMIHHESEEVEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMT3</accession>
    <name>A0AAD2FMT3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10684</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14868</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001713">
        <property type="protein sequence ID" value="CAJ1946543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001865">
        <property type="protein sequence ID" value="CAJ1954273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMT3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="223" mass="26386" checksum="E37FE290D7610D11" modified="2024-05-29" version="1">MPPYASTTRRGIHVVHADHDVRRMSSECWAQPILKQPLYFIDERFVRFQDNVIVHEYHPQEHHQQEQSQEQTNTTKWYSTKELVRFHQEANKEGRHSQRRSRPLPRGLERHTTQGLQRCLKNRLCAMALVLATQYTAAQQQQDRHSSEIMIAKAYHDITRHCQLEATETGLRDYLETLENSREEEVDLQCQYSSGACLSMPHWLSALLNKRAFQHQEKRMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNZ5</accession>
    <name>A0AAD2FNZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS11044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="535"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1947233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="74396" checksum="6E1C1474423289BB" modified="2024-05-29" version="1">MSETLGPHDVPCGTNQIKESSLFYKECEQAARLLAVVTKKEKKHAMNEAILKIIGNVRCRGGEFKKKKFKGLKAWFPENETAIKAKIKRRIESDLKKIEIEMSEQNNKVKPASNRVSSGRKSQGEGEESLGRVLEMPYHKISKKIGELGPYDVPCGSNASGQGAEGFHSDCSYFALIFPRLSKEEKDDAVQRIINSLEKRGGKFKKKMKDVGWVEESGSDTVVKRVLTCIANYGRKNGVISTETMNLIRQEVLCNRKGKEYAVVSMQRAQGFEKDANFDDSYYFLRTACYVYKTMLVENVESNKNETKWNLARTYRRLAEVLVDNGQKQGQALPYFEMAARACEELKHWDTLGAIKCQIAHCYKRKGDRSTADRMLQEAHDYLFSARWPLPLEFEMSDPTAKLFYYQYSANLLRGDGKHEASLDHYERSCLLQPTEDRQFSQDDHDNFLNISGKAYHGIGMAYTEQGKYDEADTYLRRSMSQLLKRYGPNHPEYTDNYLILAKGQMMRGKIGNARYLLENYLNLYRDKPAHPSYPFGLGHLGKTWEKEKNYREALNVYIRALELNEARIGKGIAHLDVAYTLNSIANCLRKDEKFDDASDTCKRAYETLRKLGYEDDGDHPTMVYNRNLHGRICSRDISSTYDETLLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPE1</accession>
    <name>A0AAD2FPE1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="389" mass="44976" checksum="0CF2704CEABEAEDD" modified="2024-05-29" version="1">MLPATQRIRLQSAISRLVYGVVLLAFLFNQHAIAEAVEDKPFQILCTTTRRYVKVGSYKIRCHTFKRLAEHFGKNVEVTVVPQDQLYPEWKGDNAELVAKKFDATVVIKRAIPPEERFGKMFMDVVDSYTITHENLDPAYDAIVQSIHHGNDIFSNRTFHVVEHWYNSFPQDMMASTDLPVVPLPPVHPVEVLKLGTLWTNEDEECAYLHSPSMQYTCISEKYRIELWYQDYFEPKEKPRVDALLSDPDQGTGRLYFELFWKFDVLVVPAKAGNPAKLRFGNVQRAVSQMRSGVPILLEIYGDILEDFMDEYNYPCAYVVPGKNYQARHEYMTFEKAVLQMKKPDVRRACQEAGIRIAKDYSPFRIVKKQLEGMGYKGEFNYPKGTTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPN8</accession>
    <name>A0AAD2FPN8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPN8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="480" mass="54567" checksum="FD1A085E688A8511" modified="2024-05-29" version="1">MAAKRMRQREAGYNNEGVEVDLYDGDDGSITVIHDIDHSRDDIMAASSSHSHSRSREALHNLNLSVIRKPAREVTFSNIKVRTYPICVGDNPACSDGVPLAIDWQYQKEYNFTVDYYERKLEKWANNPESPMHPNRYPRKTEAELRISAADRLQLLFSSGVMPPDANLAFRQVELVRRNREATIRSLHFWHMIYVWERIQRATRNATVGRASKKKERLMLQPYRNMEGENNSIEISVDEIPTPRRWFTFRQSDQNSSPLNNIHKRKKPAPIVLNQSYETASVATNTPQSIVSYNGDALFPPTPTSNSPLAKTIRERNMTQFEPRIIDMTGQVSGSFEGDINASPIARSPTMKRTNKPRDRGFDDDDSQLLIGESIMDQSMDYNSNVDRYATAQHNTSISSRMDEESTHSGNYFKSTASMGGGSNHSRHSQRNDNVSAITTPSATTGNISSNIRHLTGLRGWSSDNNAERGYFLDSDERYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQZ9</accession>
    <name>A0AAD2FQZ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="374"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="485" mass="55242" checksum="816921D153E82CA3" modified="2024-05-29" version="1">MNVTYRDSTSSPFSMTEDSSASGSPDPYKEEEDVKIIHTAMPEKVESSLVDSLIAKQMSSLTMDQREQAYFDIHGISNNDETPELIQQSMLEMEAELGILEDAAAYRKALDLNSQYVRQDRFRLKFLRADRFDPKKAALRMARHFEAKLDLFGQEKLCQDITQNDLNPGDMDALVTGVGHLPIRDSVGRLVRISFSHNGVDIAGSTMEILRALFYSLMVLADDEETQKNGVVFVSWAVGYKQDSNMVHVTKSDGFKNAIWAMVKLAFTAIPFRHEAFHLCYDNFFLSPIFGMIKLSLGMYMGVRVRTHYGNKLECQRKLQTFGIPTTVMPLKAADMDHAKEIWKKRLAYEKWSSNPSHEGNPRPRSVFVPGHLDILLGRGRRCQEHVGNMRLRNLVEDCKPEYDQASRKEKTLISQEIVDNVKKNSHHFLKDEDEGWVEVDDQVARLKVSHTFRDVAKDATKKKEGNTSDNASVCSETKKRDRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS33</accession>
    <name>A0AAD2FS33_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="143" mass="15906" checksum="44E0F867E5DF3261" modified="2024-05-29" version="1">MTFETLLEPFLGFFHCAGEEFNDDDVTMMEVAMTSSMTSNPALYSMPSKESMVEVRQDTIQRYGASPLFNGTASVPISFDDEMNNTHEEKRDDSMRSTSSRSTEVRQSLSHASTPPRTTVSTTSTPRRKSSQSTPSRNSLITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS72</accession>
    <name>A0AAD2FS72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS13003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS72"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="8">
        <location>
            <begin position="307"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="650"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1951296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="749" mass="85858" checksum="8B393B9AB0A8E7DF" modified="2024-05-29" version="1">MIDPSSLPTTWEVDSADFDEDASVSSNSEIVVEIKKSPMSNRRKTRITFTTNEMKEGLRQSRAVIASFTEITKFEDSDEEMKKNWMQVFNDNIMQREEINKRQFSENVWRQLVLLQDVKGMLLLHHACRRKASPATIKWLKGDDNDTLTLSHASHDGSLPIHAACRAIAPFEVVKMVMKDSDKRSYLNFRDGAGHLPLDLIGKGEPTGEKKGHLGSSLRLDDNPIFDSFAEKMFEHLINDATSEEEEIFLAMDAMCNACPAKKFQTIVCSNLRSNTCIEWLTWAFCQPNVILYIMRDFYCQLAGIILIFYASHTYLQGHTVHYVVYALYGIALVFLVREIRQIRRYVKANIFTDYLKDPWNWLDCSTILLVTMSAVMLQISDPNNNPNDYFTRRLLMITGSCQVAHFVSFLRKVFLPFATFVGGLAKVFGTLVPFIVCTGLVLLAFAFMYYVQNFNNPEALGELPYNDLWTSFQSVLLMFLDAPESTETMVDALFGLITSIILLNVVIAIVSIAWGRSTEQEMTQQLFWEYRLAFVQDVTLTKNPGKKKKGKTSKATNIVSERFDKSRSIRQEQIADPFHTVRYKRVLLYTGYFFQYVVYFVLGLFTFGLCWPDKIKRDIFGIKFQEVKYLMKPEIYETRRVHTAVTTKMAELDSRIKEQADDNRQLMEQNKSLHEKIDRLESSMDKMSEILSQIDVALNLQSKSSRPMRMLPSGEVQVVSNGDAVEDEGNDDSSSKLSLEQDQVPRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSZ3</accession>
    <name>A0AAD2FSZ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSZ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42488" checksum="14393CCE4B428CD5" modified="2024-05-29" version="1">MEDSGKEEEDKKSCCTWPKIVVAAILTVTCCIILWKYAPIDSAIDSILPKFNKTSGDYSDTGGAFGDIPPTEAPSTPDRFNFMQCKQGKECCNGLPKICHLGVDEILYATAHNAMASFEDGFLFGPNHRLQLERALFAGYRGINLDICNCAGLLVFCHGYCSLGIRGVDEVFASINGFLDSNPTEVLMMPMEINNFADESVDLDQFYFQMTQIPGLIEKVYIRENDNAPWPTLKKAVDSNKRIFMFHFNGPDCTTANPCPPGLHLYDKYAIDTNWEFRNLEDVEDSPVSCDLVLKEALSHQAFFGVNNFLSPPSYSVSKTLNSVDFARERIRACSEQANLDVNFIYADFWSEGALPELVQEHNRGLARRRQRTLRRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT99</accession>
    <name>A0AAD2FT99_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS13673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018227">
        <property type="entry name" value="Amino_acid_transport_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32195">
        <property type="entry name" value="OS07G0662800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32195:SF26">
        <property type="entry name" value="TRYPTOPHAN OR TYROSINE TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03222">
        <property type="entry name" value="Trp_Tyr_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1952701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="488" mass="51329" checksum="1FA4833E75D04892" modified="2024-05-29" version="1">MPTNSHAKRPFSSISSSSPMATTTGSSSSSSSSLHMESSIKQKSNSAFETSRTTTRTKQNSSTTSSLMKNSAKLDATSLPSFAQIQDFVMPVIFTSMLITSNTVGAGMLVLPELVQGPGMGASMGLFFALYLGNLISGLLIAEVAITQKEQSGEDAPSSFKAFSEANLDSELAKDVIAAVCVIKNALVLAFGTMKAGQLGHEVLGWNADLTSMVWVMLFAGVLGTQSAPRLSKVASLFVAGLFSSFASILIPGLAHMETPVMDVLTMPGTSSDPMAAMVTAAPIILMSFIFQNIVPTTARILEYDRTKIALSMGIGTLFPFAMYAAWCMAVLGGGVDTAVGLDGPMFTLFSVVTIAGSHLGSATSMAEELDTYLRPALDDTQDLVEQEDRKNEVFSWASVLITAAMGIGLGEGFAGNLNDLLSLAGAYGSPFLYFVLPLIMMSTQREKLASEAEPKEIISETPFPNIPLGIAASAASAFLGLQALQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTX7</accession>
    <name>A0AAD2FTX7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS13810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 99 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTX7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572">
        <property type="entry name" value="ENDO-ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572:SF4">
        <property type="entry name" value="RE57134P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16317">
        <property type="entry name" value="Glyco_hydro_99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1952975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="57474" checksum="560E778D99B905D9" modified="2024-05-29" version="1">MSSYLASNPSQGQRLSSNGASIQSSTSPYFAARHDGRKFQQTWQAIANDDTEVLSSVAPITSGFKDGIVSDRHYDAKHQSTQGGSDTGEYSPNSKRTRSIFKPCSMCCLIISAFLIYILGILTERMILKVDNSSSLTRATSLYGVSDTFASRSASLPMVTLGTYYYPWYADDFHRGDGYLRKNLGQKPVLGEYDDRDPAIIAQHLEWSKRANIELWSVSWWGKHSREDNTTREVILTHPDLLDSDFQISLFYETFGRIKEEENYSLHRVGPDMEFMCSNYFNHPNYFHIGGKPVVYMYLSRLLDEKGLLAEVIQVMRQAAQDACGQDIYIIGDHIFGPPDDSVVKDAQIALELLDAVTNYDVYGSMSKSVGSKGGYFLEDDVRRYYEIEQREWKGIVNQKNCAYIPAVSPGYNDRAVRFEENQIPLSRSLFGGAPGSLFDTAVMSARTLVDSSASSVLMVNSFNEFHEDTQIEPVTAGEWSSMAFNMTYGLSYHGYGTLYLDILRSAFRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUQ1</accession>
    <name>A0AAD2FUQ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipase D/nuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS14477</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUQ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1953880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="66282" checksum="67D964A6B49248B5" modified="2024-05-29" version="1">MEEKPSKRPRRTSPARSVNDDGTETADFLTAATTTSTTSTTNSNNKTPTNQELFLDASQTPVIKLFASIEDLKLRQDLGSREITMSSSSHLNYIMTLREILGLDPIWKPFKGSHNPTTIAQGYPGRKSIEWFALSNFLCDFSFLMEEHPELLSVRNKVFFTQSGGGNNPDSWRFLDPSADFCPLNPKEEPSTYGTPTTNPLQYKFDYGSHHTKMFLVGMEDRLRVVVSTANIGKVDLELQANGAFVQDFPFKSSVKAAAAPSSLGDDFEKTLIHYFESYGYRTKKQWSNGGPARTLVDQLAQYDFSNAKAILIPSIPGYHAILPEGEQRPREGRATKPLQGYLKLKNAIQTHANVPSSHSSTRYGPVVSQFSSIGSLSEKWLKDFATSLSVVPPTITNSMGKQQPDLVDMIKLVWPTISEIEGSNQGISGGAAVPGRIKNLTKKCVKPLLCKWTTTKTTLTSTNNSMMIHKPRSIPHIKTFFQLQHQHRMITNADNGSSNNKEKSPSFAWFCMGSQNLSKAAWGEIINGKFGKCHRVVSWEMAVLICPSIMGKRLVPFTGRGEQEGGDMPIPLPYDSIPQRYCSPNDQPWNIDYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVQ1</accession>
    <name>A0AAD2FVQ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVQ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="165" mass="18576" checksum="9DD59B1DED5444B4" modified="2024-05-29" version="1">MSAISTTGTEESCSSLRSKVGFRDVEVRHYERCISDNPSVQDGPPIGIGWKVEEEQKFSVDEFEGSREFVRQPDVNSLMLPKTHRQELLLSEGFSKKEIAQSVRSVIKAKNQRRQTVNNLDKIPLEEFMENTKRSVKGVFCIGKSKENKMLLSESQTLPIANAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW60</accession>
    <name>A0AAD2FW60_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="162" mass="17212" checksum="2C078AF3034147DF" modified="2024-05-29" version="1">MINGNPIDWALRVCESIAFSLHCCIGLSEPWTGVMKGVTEGSLVYNNFFFPLAGIFLGTIAYLNFSSSNAVVIGVQCYIAAFHTGAVFTHLRVGHHPAAAAAPGIFIVLAFAVLAIRESFLFAVMATLASVAVGVALGFVLVKPKEEHSAPLLSVLEEQESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWM5</accession>
    <name>A0AAD2FWM5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="41429" checksum="B8ED6228178B4517" modified="2024-05-29" version="1">MSPESTVSSGSFDINKMEMSEVIRMYSRSSYQHPLFDPLQDGKAKEHRRDDAASPISNSDSTLGILQDLGFSQSNIDSEGFGKKLPLWSQIIDNYGDRPVVLGLERCQAYRETVPVAKRIVGLAGLFSSGTNVMHHLLLNNCKPPEGGQKPQRSFQWQVPWGKHHPADTRMKYAARDREFLNQTAVLPVVTVRHPITWLNALCRHGYSLHWDHNPDLCDATLRLDQAVHAKFGYTNQSIVYDSLIDVWKDWNLAYFQQRKYPLLMTRLEDIVYHPKQVVEEVCHCIGGKLHSDRPFSVFVSSMNDGKGHGEHRSSGLLSTFVKFAKPMKELSDKFSNDDWDIVKTVLQDDSHLLSSLNYRMPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWQ2</accession>
    <name>A0AAD2FWQ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWQ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042279956" evidence="2">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="257" mass="26096" checksum="EB014DB18E1C0772" modified="2024-05-29" version="1">MYSIKQIFLVLSLISLASAKKGVSTRKAVEVEAHRGLKKSSSSKKSGSSGGFVAPNRGGTGGIVGGSVSGGGGVNRDGTPAGTLLQPPGKPCVPFEDASKFLSAEYPGDAQCRTADAPMGATSACCRVFSFTDANGPQRWLLYDTNNQYRDLLCVCNANTGAASNPVISVPTGGDRGGAIAPPVASPISVPVSAPVVPPTPPGRSVCENPNPTQLDLQSRPGMTACVSSDTCGSGRCCSSNTCVCMPQSFLGNAYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY92</accession>
    <name>A0AAD2FY92_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001935">
        <property type="protein sequence ID" value="CAJ1957053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY92"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="387" mass="43706" checksum="F88C70B8E830A144" modified="2024-05-29" version="1">MMKARFLGFSLDSGDDFTYVIVTDPDSDKEPRRIFTRSVIRPRHVREAAPVVVRKGKTKFEIYKKDERTILEGIADPDFPPRLSERAPNPLLTIQEEPEPLDTVEEYERAIEEVYGTPPSKRLRTDPTSDDALLRTDLEELQPLSVKTVTNSASKLPREQAEPAIQPPRDQEIAAAVPAATVEATTDGPSKPAQCPAPVTQEEHTQVTDQGEHASESDDDASVQSAGDDSVHSADGDLDDHHVTPESLDVHLQNIAGISDDEDLFDLVNGHEFHKGIFPYETAKYICANKIGSCSGNHKNGPHQHWARTFMKKTRRVMRRFVKYYGYSKPMKEGQVFSCPKEDDSYQIQYTKRFKKSTPRQNRCAKKPGRLRRPLPVKYGIPIWRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ77</accession>
    <name>A0AAD2FZ77_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001949">
        <property type="protein sequence ID" value="CAJ1957692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1957692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="257" mass="28500" checksum="4EB69B70432BD2D8" modified="2024-05-29" version="1">MDFKQKFLEKRLRSSQMNDFGQRGNSWHIGVIEYYDFEAPCQANGNTAQAVPMMFPLDQILDTGNKQDGLCVLSMLEAMMKIVTVQFHFVKRIILASDNANCYHSKELIFPICFLNQLSSGPKIIKYIHPETQDGKGSCDSHAAVAGTHVDWRYICTQKDDTLTKNEACTPTELANALCTNGGIKNSAVQLVELNFQRLDKISQLCSGAGTPATLNCSRTCQSEPASTKFPQKGGAQFLGVIFLASRIEVFAWSKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G134</accession>
    <name>A0AAD2G134_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G134"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042155485" evidence="2">
        <location>
            <begin position="25"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="243" mass="27100" checksum="F9D035E9E03B99AB" modified="2024-05-29" version="1">MGNSFKQRLFGGLLLSCCLVVVIASHQQQHPTRDDDVSSHGYFFARRDELPGANSTHKHSSDYTAIPKETKPVLASETLVAHSAVDWHLSDFSGGHSNQSILSDSGPNWQSSATPQDVKENQKPIIEDDDPCVAFGASASTPSVSGTTGGERIGDGKAPVAIPTTADSIQPDNAMYQHLKSHPGVIFIFLGWGILWTKCKLYPQLTLLKHASLQLYKRGRKRRRNRRHRNPQNRPRRYPRQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1E2</accession>
    <name>A0AAD2G1E2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1E2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="164" mass="18369" checksum="ABADC17BC8C47F34" modified="2024-05-29" version="1">MTTTSKTNVFFSSFQNNDNNSKNTNSSNDTDSITDASNATMTQTADCRKEGKNKLLVRLTNTTRPKNSPPRVINDLLRAPFSDNASPECYIDEAIHIAKAKETKRAKRQSLRRKGSSMTERSVKELLHDNSDRLSSLLMQSRSRKEMAGDGFLSSDDESDLEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G230</accession>
    <name>A0AAD2G230_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS18297</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G230"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="60"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1959878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="332" mass="36568" checksum="1B6B57AC4C24F125" modified="2024-05-29" version="1">MSMSMSMSMSSSSSSSLSNPPTLTLRNGLKHPVIGFGTYKVGVIPASASSAVASGGPNAVERTAEECVSDALDVGYRFIECAQFYANESEVGKAIAKSGVERTDLFICSKVWTTTIEQGPQAIEEQLKKTLADLGTDYVDLYLIHWPVPGKHVEAYKTLEKLADQGKIKGIGVSNYAWEDYLELKENGVKNLPLVNQIEINPFLYRKNTIAKFADEGVVLQSYRSLRDGKAFDDPTILKIAESHGRSAAQILGRWCVQKGFVYIPKSVKKERMVENSKVFDFELTEAEMNELDSLTTPDAIETFVSLYRKCVNRDTSKDGTLDGVKMTITGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2D9</accession>
    <name>A0AAD2G2D9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002054">
        <property type="protein sequence ID" value="CAJ1960217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2D9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16228" checksum="957B941D072B2651" modified="2024-05-29" version="1" fragment="single">VHPDFKSHTGGVMTMGGGAMQAMSKKQKLNSRSSTHAELIGVDDAITQVLWTRMFMEEQGYLIEKNILYQDNMSSILLEKNGRSSAGKRSRALNICYFFVTDQVEKGNLTIEHMPTDDMWGDYMTKPLQGEKFRKFRALIQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3L8</accession>
    <name>A0AAD2G3L8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3L8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="103" mass="11457" checksum="2B5F08A8C636B4A7" modified="2024-05-29" version="1">MEEEDELYGDLGEIDKKNTPATPSTSASPMVAASSKTSSLKSPPPGSIMAQQLEEKVKALEAENLTLKRNMGMLYRTARREIDRKDRQIAELMAELDETKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G549</accession>
    <name>A0AAD2G549_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002133">
        <property type="protein sequence ID" value="CAJ1963133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G549"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17795" checksum="4C2AAAD133B83523" modified="2024-05-29" version="1">MKWMIDASFAVHPDFKSHTGGTLSFGGCAAQVMSKKQKLNSRSSTEAELIAVDDVVTMILLWTKLFMEWQGYPIEKNILYQDNKSAILLEENGRKITGKRSQAINIRYFFITDQVEKGNVKIEYCPTDDMIADFMTIPLQGEKFCKFRDLILGPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G598</accession>
    <name>A0AAD2G598_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G598"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="91"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="20738" checksum="6F2BD3083F6F8BA0" modified="2024-05-29" version="1">MKLSKLAFLGSQIIVRGSAFSTKAPACVSRQPASSLLGQETPAAIRNVSSRSRSSSTRLFSSAVGGGPTLTNIDKDEMEEIVEDYEKGGREESGYLIMDVREEHEIASTGKLSPNTITFPLQKVAQYDAFSLDEFEFEEIYGFQKPTPDETLVFSCAAGIRSVHAARFAAQHGYTKLVNYMGGAYEWFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5E3</accession>
    <name>A0AAD2G5E3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5E3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="153"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="261" mass="29947" checksum="E9C452B075AA87A7" modified="2024-05-29" version="1">MSDKTTQHPLDGFEIFNAYFCDVLEDCVDTETPDTEITAIISEHFTQSHITEEQNENNAIPTKLIEKMIKNKRGKSKKKVYSKSKKPSKASLVQKPKKTLTQQDKAKKIQQGEIKTIKTTKRKEKTTEEKKEDIQKKMKDPFGPICDLRPKRDVVCEPGSFGNENPSNKELIAKVRGALKIYKDLNSRKKKTEMINHIFDGVKSGGGRFLVRLDKREREWKEMKDEAGRDKISHMFRDEAKKARNGRKAEASFASLEMVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G773</accession>
    <name>A0AAD2G773_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Guanylate cyclase</fullName>
            <ecNumber evidence="2 13">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CYCCA115_LOCUS21071</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 13"/>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G773"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12974">
        <property type="entry name" value="Phosphonate-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042185763" description="Guanylate cyclase" evidence="16">
        <location>
            <begin position="25"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="646"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="1003"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="679"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAJ1965347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1213" mass="134425" checksum="C25F40C041EF8F95" modified="2024-05-29" version="1">MRIRVLSILLSLWPLFLLLPIAVAQECQIELPSSPSLSPSLSPSPSLHNETTQREYILGGHSWHLPVIDYLNDVVGQQFDPPIRFTWKTHAEWLNAPTVEDALARGYDFINSNAYRSSCYESEGKAIALATERRVLRDPDTRLLYNVTQFGAALYTLSNRTDILTVQDVRGKKIGTNRYSNLATHLCYDVLLRNGVHNLQDPEQIIYFRRSTDALEAVLDGRVDVGCAAANTLEFYKVDDDSERLDLSRIRILGEQLHMTNDGVPYPFKVSSPLVPTPLFQALPHVEPIVIEKVRNALLAMGDHADVAPALLACLDDRGCQTNNTVCAEDCFQSLTNNNATMIRRCDTTAELALKAFTAIGDDIWGYTKPQQNLDMRDIQESTGFLVRDPNPRCVRLQNIAEAVTCPPGHFIRSSQDIINECNVSGLECYGWDCLCSPCVKAFEVDFVVTSNNNEETTTTQSSSITGTGCSKFSLCGAVEQESSISLLAVDNKKRHNITMRGAFLMSDDSRDEFVLDLVNGTFQYDFDVSRTRVGQKVVIIEVCERDEPCGEIPESPFRINVMKRSCPAELFGNGREADEWGVCVCKGGMVDLGRNCSSIAAITVVAVVLMMFVTLVTVMIYVRKLKDETQNDMLWTVKHDELKFNAPPEIVGRGTFGLVLLAEYRGTQVAVKRVIPAKTRATLESSFHQDKTEPTGIESSEQLNQSQNLGLRSGFSGARSNEDAEIGAKASWEKLRSNFVEEMRILSKLRHPCICTVMGAVIDNKDEPMLVMEYMDYGSLHDLLKNNTMAINGEVILPILRDISQGVRFLHSADPQVIHGDLKAANILVDSHFRAKVADFGLSQKKQLRGTGTPYWMAPELLRNESAQTAASDVFSFGVILIEVCSRKDPYEGEDPNTVLKEIADKSIQKRPTVPASCTSQIQSMIADCLVDEADSRPTFEEIDTRLKRIDTAAADILPMAKNKTLKRPGTDVGLQDSFPSHIAEALQGGRKIEPEHRDCVTIFFSDVVDFDKISPKLPSHKVADLLDRLHSKFDALAKDHDVFKVETIGDTYMAVTNLVKDQRDSHAKRIADFSIAAIAAGKTTFIDKDDESKGFVSIRCGFHSGPVVADVVGIKCPRYCLFGEAVNMASLMESKSLANRIQCSVASVKLLKQQDASIKISSRGMIPIKGKGVMDTFWVDESSNVHTPFTVTRQELDDVWSAGAFSSIETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7H2</accession>
    <name>A0AAD2G7H2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-ornithine N(5)-oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS21261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7H2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041989228" description="L-ornithine N(5)-oxygenase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1965668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="71082" checksum="1A889A82002A4798" modified="2024-05-29" version="1">MKATIPTLLLLWCISIHSLLAKPSHSHRDGDEEPICDSSPLRPLRIAVIGAGPASLFLCHALEKLIKEHGIHTKSGRKMEVTAFERSSHPGGLWQPRNNAKSGVTIYDNMWTNGPSFQHEFYDYTYEEHFRRPVDVYFPRKDVLDYILARVQQNTTDFFEKYVRFDTEVINVRFSNAKKVFKVTVKDLMTGAVTSGYYEKCIWAAGAEGVPNVPRYASDLEEFGFEGRVIHSSDMANFEKDVRGKRILLIGGGLSAEDLALQAIKCGVEKVFVAARAKFGSSISMTTAWPDNKVEVLLGWNLASITEDGESLILESVTYDGEYYSRDEMYDDIFLDDVDTIIFCTGYDANINMLENSLQKGVSIDLEYENVESPTVSEDWSMEENCMTSRLGDVQPSLYLEYESGYNNPMVYRGVLISNPNMMFLSSFGSETPLLSIDVSAHLLAGYLYGTINLPTKTEMQKKNLERFHHMMHNPFSRMDADYAYSVAIEQWMETVNSTERLNASDEVVTTSAYCFDLYYLHQTMVDANYPIKLVGPEGLTCPSKFDHKIGNRNYLMPKGLTELGDLFVSMDMLCGEHRGSTRNDNRVKDQTPSKSTYRDYTDGAKFRSLHTHNEARPSLDDMWVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7X5</accession>
    <name>A0AAD2G7X5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="2">
        <location>
            <begin position="161"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="3">
        <location>
            <begin position="413"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1485" mass="165902" checksum="722F7E91CB631F94" modified="2024-05-29" version="1">MLTPLTNIRGLSTRRQIVFVTRFASVDRIPFIIKQNTLPIKWQMNSEEETVLRAIVISSSDKWSGQPITLADRQAANGILANFSTFDGRIQLSLKWLQLPQVIADGSNDCTLSAKLYACEILAGVFKSKYATLSDQEKGTIRAALLSQAQQQARLAITDSRILPNKVASLIAGLVVRDFPQRWNTAITDIFGTLWSTDGPTMGVKICLEVLKLVAEDCTDSDYNAKISTQRRNDILIGLNETSHHFLPLLFRLLEEVATLSQGKMSLHQMRQYLLQQNQTIASMTPEQSAQYQLEENKVRAVTVAIVDTLLTLEEFCRSMPLDWILSPQHDFGAACFHLIRESTGGIQVRALTCLEHLCLRGKLTYDQWIKWINDLPQVIQQANQVMAGDLEYKQVNDAAAGINDPSFDALSEQLEFHLALSRMLAALVLAHIAHVTHDKKILKSGSPDQLAFSTYLRLLVDMLHHPSGLICSSQLALWIAMLRDPQISRKKLLQPFISEILICYMDQIIKIRWDDVDDGTHPQSTLMEASWDDDEEYDRWIMDFRSKTSQLFKHIGNCEPDTAATVLLTRMQAMFAASANGEPRTHLHAQNQQLTHDSEAVRQFEATVQPIENILQGMPTWSLSKPQNGKQNNNKRERRNRTVSCLSEIANLVVSWNPAYLWLRFRQVQLLETLRHFWSHEDSTLLQGIDLLLRYIGAPDEFGDGSIELDGTKRISGETIALRKKSSTALVSVSKQVPQNLVPYIPQLTDATRMLLSSPEIHPTNRMHLYEFLSGVATAVDDPVQRATFVSNVLADAINILQSKETQDSISSVQGILNLIGVAQAGQNPATVTDPAHVKTVTDRFAAIFSAFNQLLSVGKRCHEANKKRPTGGLPMVSQATNISSDPNEQNFPDEGPVSTQDLSIGDPFVPLWIHILPAVLSVLESLMQMWRPENQAHLLANRIQRYSLAISDDEVYLSKKQSSKSGGVFGEGGTAGSVISGVSRRDLNLAPKWSGWLNELRNSCFQLLGLASAQRALYTPELQPLFMRFVQVVADPQSLQAMENRHCTQYLKSFIEILLLTCPKTLYMTHLAPIIGPLCEHMKFRLEKSWEPILKATRSRPLSTGDCEAAAAVAIRGGDEWWTEYYSRSGLFVGDLDADTAETAVEKTRIEVTRMFCDVIQSALALKGDWALTLANLAREEQTQKQKHTSKGTKGPPNRFTEGLINADGTPKSENQAAIDVRKLARISAMCNFLFLEHEQTAGFLMLTLIQCLEYPDAYTCRRVTKICHRCLEAVAWHPRYTEFLGSQMFSVAVKNVVVEPKWMVGMEWDMINVVRDIYCRLVCGQVVQPGGQGAALQQPASSSNSSTYEQAKTADRPLQGGGILTTPSALPQNVLLSLPGITAQMIEQLNQDLKRKRASKDQKDFIKDFLRIAADNYSIAQPESLGIDRLDRATKKESLLHSNTIVNEITDPIATNPSRKKKASRKSKMVNQPTGLTAFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8S3</accession>
    <name>A0AAD2G8S3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS20404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1963964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8S3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677:SF59">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="132"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1963964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="355" mass="39855" checksum="38B8252F37F77E27" modified="2024-05-29" version="1">MTPETTQDDTEAPAMKEGDYYLDEDSDDNDSQTQKTAYCCTGQGKPITTAELWEEFKDLSSELWDYVRYRCWKKKLLTAVLVICAIGVCCDLAFGGLFLNWLALFVAWMAYHPVEGVFAYVAVFVVATLLFVPEIFLVFAAGFAFSAAIGTWEGMAVATLASFLASGISAIIAFIRARYMMRDLIQLFAKRYPLVMCADRALERNGFRVLVLLRLCPVIPYNALNYCAGVTDISAEHFLQSLVGVIPFQMFLATVGATTARYSAIDLHNNQEQRLILFALLGAGICFGAFGVLLIWRLVKQELQKELELSDKQMKGYITMNPDDFVEQGVEVSAKRFNVKEGDEDESDQFFWVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9F7</accession>
    <name>A0AAD2G9F7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002260">
        <property type="protein sequence ID" value="CAJ1966186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9F7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="460" mass="51984" checksum="FE339399FA0466A6" modified="2024-05-29" version="1">MGKSTSLKVVSTTANKAGGSTPKSVSVAKKSGKKRLENASAVDLRQPKDRDPTVNNDSEIRELIASLPPLIDFGLSTHELIAIGYDYNSTKISFGNSIYNQWMEEHNDRWTQALPRFDSPFKDLYANYSVEVRVNMLFAQYANDWRRVLKFLISLFDDDALGNVEKTTEYTWGVRAIALQVAQQIPFSFFDVGLVNDSKVPQEDLYFLRDDRTNPALRNETPLVQFWLMCASIFDHPWTMLFDEFLEESPISCIQEIKLKVIEGFPNDETNMVDIHKGVKKIFDPDYEDSEEEDDPMGDEDTGLVNQFGQPDGWDSDETVDDSNDRRNDMEIDGELASGDDCTHYDNKDDKGEAEEDDEDTDESTKDSVILVERTYDPTDTANDEDNNNMGLNTDEAVSELTGVTGEDKDPELASPPRKKGRSHRVSVHTFVRQYPNAPAGGLKPVRTKPMLILTTRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9H0</accession>
    <name>A0AAD2G9H0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA/DPMS transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9H0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA_DPMS_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA_DPMS_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA/DPMS transmembrane" evidence="7">
        <location>
            <begin position="86"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="238" mass="26362" checksum="597A596A57CC69DE" modified="2024-05-29" version="1">MAASHLKQRPSMQQSALSTPVSNGEGVYNAKGSRKGCPTSCISKIEQIKCGGKPIVSGIDRVVFGTQPAAELVSIFGMRPPRYLFYMMSGIVCDIIQFLMDVCLHVVLEIKDASVCWSLGFFLSIVFRHTSHRYLVFGDYVGGYWKSLGRMYVGYSIIISLSTLFNVIMTKWAGLPHYVAWIVTLLWTGIVNYFILKKIWSFGGKQANTEATSAGTSNGDMTEAEIEVDEEAELVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9P4</accession>
    <name>A0AAD2G9P4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS22532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1966946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="319" mass="36095" checksum="A05B1138823F5F5B" modified="2024-05-29" version="1">MGTMKPKLPADPLIFGFWKVPKNICADVCYKAISAGXXXXXXACDYANEEEVGQGISKAITDGLCKREDLFVTSKLWNTYHKPEHVPLALEKTLKDLKLSYLDEYLIHFPISMEFVPFESKYPPEWTNMDGKMVLVNNDMCATWKALEDQVDKKLVKTIGVCNFSTQLIRQILSTCRIPPSTLQIELHPQNSQQKLIRFAHEAGMNVTAFSTFGASSYLELNMATKEDVLMENPVITKIAAAKQKSPAQVLVRWALQRNTFPLTKTSNEGRMKENRDVLDFELDEADMKEVDSLNKNCRYNDPGVFCEAGMGTFCPIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA41</accession>
    <name>A0AAD2GA41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042018514" evidence="1">
        <location>
            <begin position="22"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="279" mass="30731" checksum="D2BC255CE1F56176" modified="2024-05-29" version="1">MSSSTSAVLVGSALLVAAAAASSLYSSKADSTSTIKDIDDDEYDESELITSEEVTKIFDRLFLEMQGVLAQLSQMVQQIQMSGQVIPEKQLRMMIKAEFERALAAKQTLVLEEYDMDYDCLEEATWEFMEKEEEFPKVKKSVERFQKLWENVSGEVVVGMRPGKAATVEAIEILSPSKTVEAAEIYFDALTMAMKGLVEKMKEDGQDLNSPAVAQELHMKFASVANEAGEDSLKAIGLTQVQFQKSIEANASNPMVGRALAMLQMKQQQALMAMGVPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAM1</accession>
    <name>A0AAD2GAM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="2">1.4.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS23057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1968040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="264"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1968040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="553" mass="60917" checksum="8A87A8C419682BB3" modified="2024-05-29" version="1">MARRQQQPAKKKKRGGRLSSLFLPRKSITILLMLSLVWSCKASSSTSSSSSSQSTFRPSKPSADLEFLEPLYQKYPHQPIFLQCVEEVALSLLPLFSDDNEEGQFYKRAFLAMTEPERVISFRVPWEDDDGNLRYNRGWRVEFSSVLGPYKGGLRFHPTVDEGVLKFLGFEQIFKNALTGLPLGGGKGGSDFDPKGKSPQEMKRFCQSFMTELHRYLHPSTDVPAGDIGVGGSEIGYMYGTYKRLTNRHGEGVLTGKSLAFGGSPLRPEATGYGLVYIAKLAMEDQRKKDCKDDKDAEDNNVLKGVKCKVSGSGNVAQYAAQKLLELGAKVMTMSDSNGALIFDNDNDNTGMTQEDLQQVMECKNVHRGRLSQLEGKVSGRYIPDATVWNLPPQQNVACEIALPCATQNEIDESAAQRLVEEGIYLVAEGANLPTTTHGQEIFRRKQEEDGLVYIPAKAANAGGVGVSGLEMSQNAQKLTWTTEEVDDKLQSMMKEIYHQCQTGGDTTTTTTSSSSSSSDEKEEAASMSLEEGANRAGFRKVAHAMRELGWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB99</accession>
    <name>A0AAD2GB99_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002278">
        <property type="protein sequence ID" value="CAJ1966333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="10741" checksum="EA00D8F604DCBB3E" modified="2024-05-29" version="1">MGFVPSNWRNLMNFSIEKKAGDFRLSKMRTIQLMNLEAQANNKKAGRAAMRYAEEHSLIPDGQCGSRKRHQAIDLALSKRLVWDLLILQRRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBZ7</accession>
    <name>A0AAD2GBZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS23774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBZ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="101"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="103"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="398"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="451"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="510"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1969562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="575" mass="63189" checksum="CB7BDA7FA8F66A63" modified="2024-05-29" version="1">MMSSSKKRSATDGGFSQGDDDSEMKARKQRVKVSSPSKKSLQNSQFLDDKKSLWQQAMEQLNEQTKKVLNRAKTDDDVFFACMEYTRHRDWITQRYNPACGRVVSMGSDDCNQLGVAASADADKECEYPPTFVNLDGSKVAHVAGGGLHSLVLTVDGKVYSFGNNDDNALGRGEIHEDRLHLAEPIKEGFRPDDRNRIVGIDAGDSHSLFLSILGNVYQSGMYKDVDSGKFHDVPIGTNESPKGSNVYPTLVDLPGPVREIKAGEAFNAALLEDGNLYTWGMGHFGQLARSKTMGADLKKDEKGNSIPGVYELGKMWIGEEYETDEQEKDGDGNLKFDEKGNPVWATAYRYHEDLIKEKFLKPAPVIWANPYPKRSVLSLACGELFILVVARDEGYDTNVYSAGHNGFGQLGHGDKHERHELTPIKFFERKLIKKVSAGTSHGLALDMAGNAVFAWGRSDYGQLGHTDDIKGGDIEMSPQQIAFPESLGSTRIRDIAAGSSISMAITEENDVYTWGFGETCATGHLASAEDIKRPKKLDVLRQALKRGGAKSKNCHVLEGTGGAQHSLMILECFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCC1</accession>
    <name>A0AAD2GCC1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCC1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="276" mass="31624" checksum="54A1D3B2BCD190D0" modified="2024-05-29" version="1">MLKCSRNAIRYHPPTREMVIKQCLIVYAFALFVASWSNWGVSETWWPIRNNVYSGVFCLPMPYDFRSTLFFYLLYAPLVFFLPLFYICYVVFDIAKNKLLPHREQRKTLMIFFRLLLVYFVMWVPALFLTFVAGNWLSWPYVTFGAIWAHLQGAVSAATCIQKPDIQVACKNLVFCCTRKKNQAVLEPIPTTLEKPAQIFLGIKERSASINLNDEEQQDEVDDNADKDDDAAHKSDTTMTSSSRPLRRSAYEIAFGLEAGELHSIPPFSESASGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCK6</accession>
    <name>A0AAD2GCK6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040385">
        <property type="entry name" value="RABL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932:SF1">
        <property type="entry name" value="RAB-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932">
        <property type="entry name" value="RAS GTPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="749"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="90790" checksum="765428CFF5D2A86D" modified="2024-05-29" version="1">MGTTESIFWEDEDGTESVDPQRHFPQSQQSSLKQPSSRPSPSKPSTGPRKGGRHPPPPIIRIRGLLLGGPKTGKQTLLARLQGIDPYGPNLESHQPTNPSAPPSAPPIRTASIPYQPTDQKKCWDRILLHVQTTRTIEPELHGATDFAILLIHPLHKFEKTRSYVLSVFEKTRSYVLSVVATLLRQAGYKPKQQPQTKTEESKNNEPEESKNNEPDNKAQAEEPQNEPSKDDDAERRPICLCVLFNFRDFGQPQEQRAEIQDNIKKLIRTLIQDHFEVPASMVALQFAETCLRNCYGLNVLHHFIYRTYLLRKEIDLQRQLKQVQQQATKTEDHPVMSYDEFVQVLEEEERQEEQEQAERLARQEQAPLEPQTDLVAEAAQLRQQMLLQQQQLQQTQTKQQSRSASRMETKSKSKPTPHTTPQTKQQPKAGASDLTPIRRNVMFQKLPPQFPSGMGKDALEAFLADSSDEEEPQRAPQQKVKKPKSNAVFDSSDDDDDDDDDFFYDEKGNRKVNHPSHHILRANPTSTKSTTASVPPAAAAASRKEIPSPPKPIPSKPMEPKSTTPMVDEKKEGVEVPKEMKSPKAPNAAAHDDNDHDGSQAEISSPKEVSAQETKQNKEESSHTSANDADAPASPAPNVTSKVAADDDGWSDDDDDDYVIETTPVLDSDEEDDGDTPRTPAPQQAGRSDKIPKATPASPMQEEDDDNEESSDFVVAQGTSAVITSASDDDSWGDDDGDGDNGSYQPISSTPAAPAAPSPTGGGLSAAAMAAIAAAQREAEAMLHQQAAPSTVIPERKKKKKDKSEKKEKKKKSKKKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGP1</accession>
    <name>A0AAD2JGP1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="211" mass="23317" checksum="F4567AE0528AA8B1" modified="2024-05-29" version="1">MMKTHTDSPPSALTVFMTELQASKSVVGLIADNPRTNAPFLQIPAKRSDRVPEKAMRRWVAMECQRIDTILSDSPNSPNKAASSSPDDGCVSSPLLVPTNDTPKLPPIEEYFFKAPFKPERRDSPGHAMLHTDAFFPIVPSKDFVEQSSSSPKNPMESNDRRQEFLSRMTVGPSLSSSSRSTPSCCSNCFSPPVCPRRKQSIDSPDEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGS5</accession>
    <name>A0AAD2JGS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="225" mass="24586" checksum="DF52C75B008DB77F" modified="2024-05-29" version="1">MAILDLSDESSQGSISALDRALVPGLTSSSGGDSKRSIEADESVSSDSSCSASTSTVATNLDSSNHCQAQTARPEKQTRRVKFSDKARIRKIPHHSSLTAEQIAEMWFSKADYKALRKDCAQRIKFLDKVKLKHPNEAPFCTRGLLNHTAEARAKKNAYRDVMYDALAQAMDKEMEEGLDDALAEICKICSAPSVKTARVQGLRDAKDAQKIHEHMSSGMVGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIJ7</accession>
    <name>A0AAD2JIJ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001826">
        <property type="protein sequence ID" value="CAJ1953511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="192" mass="21521" checksum="EEF5385EFA00ECC4" modified="2024-05-29" version="1">MSSIEVGCTSCDGVGETVVTPDAGKVPTVDTRFFNTGDGHEGAPAPQVTPNEETAQPSASFKNYIDDDIEGEMSTSADTSKARMASFAEAFLKSLPWRPVKTAVRKRKPHPFESHLVNEYQEQSLKETMCRTYPNLKNQFSHEGDWILPAFFVYAYSFVHLLIYCVVSHLITMWIHGNFLQRLFAKIAPARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIQ9</accession>
    <name>A0AAD2JIQ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="12">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS14959</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIQ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000190">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 12" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="13">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="14">
        <location>
            <begin position="164"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="74"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1954367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="282" mass="28910" checksum="D50349D220CDC6C6" modified="2024-05-29" version="1">MTENALSVGFIGSGMMASALMSGLVEKKIVSGPSAITCSDVWQPSLDMAKEKGFNATKSNGDVIGASKDAVIIAVKPFVVAEVCQDIAKVNSDAVIISIAAGVTLDFLQSKLPGRRVVRVMPNTPCLVGEAASGFALGNGCTDDDRKVVESIFGSVGVAKEISEVLLNAVTGLSGSGPAYVYQFIEALADGGVRSGLPRAAALELAAQTVKGAAEMVLQTGTHPGQLKDNVTSPGGTTIAGIEALERGGFRAATIGAVVAATKRSMQLGGISEEEIRYKHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ48</accession>
    <name>A0AAD2JJ48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ48"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="126" mass="14737" checksum="DD0B8451065F9C9E" modified="2024-05-29" version="1">MAKSIRAKCKRKNRSEFRRTLGEAAYQKQQAKVQEKMKDCIEKNSMQSYERLSNLLQPNADEEVQVMETNLGIDAEPATVDLKGENKAPVKTRGKRRKHTLRTKKRSVDKEQKPAEKRRPKFFVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKP9</accession>
    <name>A0AAD2JKP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS17390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="91"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="312"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="457"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1958864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="525" mass="58157" checksum="850E420E74572500" modified="2024-05-29" version="1">MAKRGKRRRHNQQAEDTAQKKRTREGDSGVSDEGNAVAVQASYTGSDDYTIPPPFELSSDESSKSDVDKLWKYVVNDKDWKATPIQRQLWSILLKKEKSVVGIAPTGSGKTMAYGIPSLLRQESLLVLVPTRELVQQVAAVCSKIVKGLQDSNMEKPYLVVPIYGGVDKKSQREMMDQVNDKTLAVVATPGRLLDLLKDSTFATSFQPSWIVLDEADQLSKDGDLGPQVEEILGIVKSPSTTLAMISATYPDKAKAKFEKWVDDDYILVQVDSVDAAKSSFGKIPPNLKQVLHVCSDHKKPKKLMSTLQMIQKQQTGRNVPLGIVFFARIEKVKYVSGLLEKEGIAHISLHSQLSTPQRAQSLHVFQSGKRPLLLATDIAARGINIAAVQYVIQYDFPSNLQQYIHRCGRAGRCGQEGTVYSFFTRNLKALATDMISLLEKTDAWVDPNLRALVGNGASKEKKSKGGAKPKKNKADFEKKNVKRTDNNLEDDDNEEFPELAPGRIVLKRASHVSDASSSEDENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL01</accession>
    <name>A0AAD2JL01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002043">
        <property type="protein sequence ID" value="CAJ1960051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL01"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="308" mass="33898" checksum="57CEA7FEB826AA83" modified="2024-05-29" version="1">MLLNLYKPTHQSLTEGFLKTYSLNHLPESQRNQFATTMETCGIVLERNEAIVLEAARRKQTPNKGGDTKGKNRDKGKPDKEAPSGAAFAQHGGKGGGASGVTCFCCGKKGHTCDKCEHKNNPPEKWFNPSKFKRYSMLHGWDVQLANWKGTGKKALHETIKKGYRVQFDSDKMNAFVVTSPRGLTEIYCHHPNGLYVRPLINSPPEFDDLNRDINIRAILMQSGNDANGPNHTNDNNILSGSSGLQTVEKNMEGFTDREVKAANAARAGYNIAGTPDIVKFQHAVQTGLLKNCPIIVTDIKNANAIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL82</accession>
    <name>A0AAD2JL82_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="88" mass="10077" checksum="7F32181D2AA34170" modified="2024-05-29" version="1">MSVPTKMNVISTNMTRANEMQKVGELKRQLQVTARSCALRGNRPSLSERRSQELLSDNSDHLSELFRKNQNCLVDFESDDESDLEEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL96</accession>
    <name>A0AAD2JL96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002075">
        <property type="protein sequence ID" value="CAJ1960857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="268" mass="29637" checksum="71B77EC8BE3C481E" modified="2024-05-29" version="1">MIRYKGGTMMYDSVATLFGRIATILNGFNHKNPPPTNLSDLAGVAFQAFTQEIKDVVAEHLETGAAGPLLVDYPSNLSRMHRLHNQAEKEERRIKQLVGIANSAGRVRPNRSYVPGLSAPPSPGGRAFAGFHQQEFQGFQDNCSSQTPTIETAGTFHTALTPTPKQNVRVTDGQGRQLLVPTPNSKLYCPQAALTMLACMSAAKEALNIEEESDKPPLIRCWGCQRIGHSFRECPHKGDPGVISQFEQSLEDYRLKREQRRHKSKLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLZ2</accession>
    <name>A0AAD2JLZ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="481" mass="52989" checksum="40FC3C9FA3F6DACF" modified="2024-05-29" version="1">MARTRTSRRTVLKKTWKNPNEPREGSRRSQRKRVPVFKAPDVIRHRLLLEPTLARRKARKRRREQDNDHDHDSSDGKSTLDKRTERMTRKDELRRKLGPHGLGNSESVSVASESKIAATPDNILSQQPAPSNHSATTFKTNSHSRNRSAKTTVSHPVEGPPKYHRAPTPPLPPPPPPPPPSVTVATRTKPRKSPPKRTATPKVPTIQSPAAARTSNPASTAPHHCTAAPKEPIQNPTAAAIASPVEQPTTIPKNQHTDGRGVAPNTIPIRNQAAYIASPPVGLSTCDSEIQSFMAWNHRQILEDTQTLKMLQKRERAIQLMQRAVDVPSVIASARLVREFYQGVHMDSATRVVLEEAEGRGMVWLSKLLTRSFSKPVVLGGIGFPAAKAKLIADEIVINLGDMIGKIDTTYHTLVGIHILPNDAVLIVPNIREIARAIKEKSLAFRQDIILKAQTSFGLQMMPTASYPSSLSFGTSMAYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLZ5</accession>
    <name>A0AAD2JLZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS19630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677:SF59">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="158"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1962324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="382" mass="40917" checksum="F45A12B5A439B91B" modified="2024-05-29" version="1">MIKPGDTEESSASSSAILVESSSSSSSMEELSSSSSASPISSSLDQQSPNNNNNNNNNNNTSAMDNNASALPAQTEGRQAPKEESLLERLRAKNREWHKKGLCMFLLIVVVVLLILDSTKFCIIPMLLSDFLEWVEQNPIPGIFAFMIVFLVATVLLIPGAILTLGAGYVFANAFGISKGVLLGSISSFLGAVAGSLVSFLLGRYFLSGWVSRMSTKYDTFQALTTAMEEKGLRIMILLRLSPALPYNILNYLSAVTGISIMEYTVSLLALLPGTVLYVFLGASAGSLASTNESGNGSTTTTIVIVTSIVFGIAAIGLTSYYAKRELNKITERKRRIQALSVTEVLSPEDLNSSSSGFETAPAMEEGEGEHEEGEEESLETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM92</accession>
    <name>A0AAD2JM92_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM92"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1205"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1207"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1244" mass="136633" checksum="57995FDEB89974F8" modified="2024-05-29" version="1">MDSPVLIPRLIPDLSAQDNGDHNHPPSTSSKKYSKFSAHKVNVNRKYRAVANVVNTSKQRIRASFKSRAAQSSSSSSSALTTTTTAISSNKFQQLNPKQHLQKWMQPSEIKRKRTLNQRLQSQFAEIQEQNHDLLQQIRMEKMDFSHQRTELERERLELERSLGLNVNGDDDPKSTRSHHQDATGGQQQRKQVEQEPTRTMKPGIRNVPTPDPSSNKRLPFEASSGDPMVFSDESKTDLSTEVAASNSVIAASSAPVKEDANTLNTTNANNNHDDEEVPEQQQQQQIGFSDETKTELSAETFSNKSLAAANSVPAKQGATTTKTALPAEISASSAPDEEDATTTTANCDDDDEEALEQQQRPKFFSDESKTEPPVEAAANIVLDGEDANSTASANDDDDDEEEPEQDHLQSGDSLTDPRLQILTYFNTVSAEEIVTSSLAASPSVAEDPTTLQSERPPVMNGKEKPSSSESSVFTIWRPTSAEAIRKMVEGEGVGKGLEIKGKSSKAGALSGFVPYLQINKEEHKSKVRTMERGGRTRIFFATEKARDAVLDDLGPLQNNILNAVQDAKRTVRHSVIQVLYVPHHAKKKVKKAGKVAKKTAKKTAAMASSTVSLATNTVSTSVVTAGNAIHSGASKGLSQAGGSVSKLSQRTLNSVSSAGGAIANFTSPVSTTVAKATNPVGNSVAHFTSPVRSGVKKGVTMAAGTVTSSLFKAAKGVSNARVSVTDTVTSSVSMAGKAAKKTGKVAKKTVTQAASTVSTTVADPVAGSVVHVGSSIQRRASMVGAQASSTAKTAVRGMGISNGEQDDEVEFALKRLLWDMDDPSIRKIDDYSPRCYGIELPDRLLWQAFVVDSDISRPEDSRWFTGRPSQPAFQDMNLIAISKSRKNQKKTKKKKKKKKKGVAEDPLVVLWQTCTGDGVDDNPLDPRGLVMAYEECGRVSPVVSDFDCFTMGTRQIRYDVLPEEQIKLLDWCVSNIEDVLDRQNSSKDATWTDRWLDVLKSSAKKGFHPEIPKYGFGDAKSYDIVENAVDFLQESGAVRHGAECFNFYFPQDLDDEFLIVSESLPDDPKWRYVGVEELLDFLFERVKEGYTFPLNPKWVLCDDGRWKKLFDCLLTSEAPFVQESLEAWMPQSVRDKIEAIRVRHPDGFVSDKARDDEVCGTEAMDLAMLNIDRYMILRRARNKLWLMGFFLTLLRTVRERRAGLEVDNDEDSDEEVGSQESQEEGEGWNGGDESDELSEETDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMK8</accession>
    <name>A0AAD2JMK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="393" mass="43828" checksum="7ACE90E66EB789AF" modified="2024-05-29" version="1">MHGLHLSRFFSGRPPPPPIQELNALLHEEPYATIAYCIFWAMLLSIGAPIAMIVLAVMLPLHLLKYYCFDHRILPIKSEHKELAVVITGCDSGFGKELSFRLAAEGFHVFAGILKPSSKDLFRGEALIQPMVLDVTNENDIKHAYEKVSKWMKAGDKQRCLHSLVNNAGLGRFGLIDWITMDDYEICMKVNCYGPIRMVKAFLPILKDQAIQGSHTQSQIVNMVSCAGMASASGLGGTPYEVSKHAAEAFTDSLRLEMKTFGIKVIAVNPSFHSTDMVDSTDELLDPENMWNGLSKTHQEEYGKTFVDKLCVHTRTVIRTATWDFKVVIDVMVDIIQSSSPPAQVVVGMDFRYGLAGVRMFPQWLRHCLTLVALPYLEPAAMTPSKPLEAKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP46</accession>
    <name>A0AAD2JP46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002410">
        <property type="protein sequence ID" value="CAJ1968832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="169" mass="19004" checksum="9FFABB5B6A48A85A" modified="2024-05-29" version="1">MLESYLCIRVAVAVDDNKPAVGRVVDVNLVKEDGKTVNTANYIVEFDGEVYFEGNRTDRVELNQEQVLYAMDFMKEIESFEDDVDEDGEDGACVPIKNDLTKMGRVFSEIRSKMGNGIGVDRISSEFFIPTYSCRPWVCMMRLGGLEWVISTCKRFNGNHPATVVNPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPU5</accession>
    <name>A0AAD2JPU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS24422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002513">
        <property type="protein sequence ID" value="CAJ1970404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF10">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="853"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="888"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1379"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1423"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="722"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1970404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1637" mass="182099" checksum="2F0FA7AA808F60CD" modified="2024-05-29" version="1">MKVMESEAMISIGSNKHETGKEAPIVAACRHLLKPNGSIIGDEVAKAILPRFPDLCSALPADSFPHHQALLGTGDTHRAPLTQSRVRQFILSEFGPQLHQLGYGSGDRIALVLPNGPELALAILSISHWASCLPLNANGAPSELKKDLEAANTSLIIGIAGVESRAIQDIAQHLGIPFCGLKPSSTETAIFRIETDRFQREQTGRKEQENGYRGHLLPNDHQSEVLVLFTSGTTGNKKLVPHRLGDMLIAAACIAVSWNLTPEDVNCNLMPLFHVGGIVRQVFAPILSAGSVICCPSFDPSIFWGLLLQSDNASSNGIRTKFSWYYAAPTMHQILLETMPAALELAKARYPLLQPQLRMIANAAGGLLPSLAEELRQAFGGANVLPSYGMTECMPISSPPSNYELTKPGTSGVAVGPQVGIFNANEEKLSPGKEGSICVRGRPCFHGYGDRPQGEGFHDGWFNTGDLGYLDAEGYLYITGRSKEVINRGGEIISPMEIEEEVLFHPSVSACAAFSTKHNVLQETVGIVVVTSPNSKRIDLETLQDFLQSRLAPAKWPQLLVFMDALPKSHTNKLLRVKLGERLGVPEMNDGMQPIERTFDARCPSQGTPITTPIQCAQVTVDTALIERALLNDLGVDSSGHQLLVTKHPHRNGSIVVHVHNLNPHDVIKIANESLHAYQRPSHICSHEDKTIMLRRDSCEKIVPKPTDSVDCLQMTLKHAAAGSDPVLEKLRGIVQDLVDHDHLPSPETSFFRLGGTSLIASQLASRIRKQFQVSFSGADIFQYSTCLAMAMKIKSEKEESSRNQSPFNKPSQRHKAGTAFAVKNSRGGLQEVTFDATKLLPRKNTLKTLFQLVPGFFVFPWLQFTRAFLFFALLFEVLKDLPVERNVIRFIITVAVFHLLWSVFTPLIFVLIKWTVIGKYKSGRYPFYSVYYLRWWFVDVCRKIIGRGIWGTSNFLLIRYYRMLGANIAADARIAVEAEIAEFDLITIGHDASIEYSTLRGFGVDNGAMQLGPVRIGTSASVGIRSVVAPFTEVPNGAHVAPATSSYDITYNSDRHLEYNRYSARPPCWALQTFVGSPIKLFVDIFSHLPEMYIIFVMMKALRFRYRLELGEFSFETIGDLLEWLCDPVRLPYFLAIRIARTTLAPFLYMLAALFVKYVLIGKFCEGPRDPSSEWDRMRVWLAESLFSHSHVQAVADLLGRHYNLTSAFYRLLGAKVGKRVFWPGTQPLCSGIYDLLEIGDDVVFGSRSTILSASSTAFEKVIFCAGANISDNTVVLPGSIIGKNVVLGSNTVCPHRRYLPPSSTWLGSQQGEPILLQYLLETDLIPQYSNDVKFSDIQMSGDSTTLRPFGRAVYLQQAKFFVCPGWMMSMLHIVYEASLTCFHAMPLVGTIYVSVDILYGWERSDRDYEQEISLLHLYGTMLVIFCILHCARILIGLSFEISAKWFFLGRRKMGRYNWDESTYNQNWEFYQLATKIRKVQSRSMLDFIAGTPFIDWYFRALGGSVGRNCCLYPSGGDPYMPEPDLVSIGDCVTVDMASIVCHLNTKGNFELVPIHLESFTTLRARSRVQQGVHMESNAMILEKSLALTGEVIESRSIWQGSPAESIAEYDEQTESERTDETLSLLHRSDTYGTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU17</accession>
    <name>A0AAD2PU17_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001730">
        <property type="protein sequence ID" value="CAJ1947520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="110" mass="11530" checksum="D8A91A76F5028514" modified="2024-05-29" version="1">MEEARVGGSRTACRLQQAAVGLCFGVNVNIALLPPVQLGERPVLVQVAFNMAPMNLEGKVAKQGRDGGGQVKLRARQGQMSIGEGLIQGDEAVTGHLNQRLAGKGLQLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV46</accession>
    <name>A0AAD2PV46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="510" mass="56878" checksum="522023663BD17848" modified="2024-05-29" version="1">MNNHLTHQSSELSTLSPQWIDESEDGDDSQLFFVTSYSDFSSLAHGPRGSEAKQSLYVYRFNPADGSLVLVNIQGDPKTVMNPAFSRYHPQKNVVYTCTEDCMNNGKIFAYKMGADGTLEQFGDAVDAGGTSTCYLTIDREQKNMLAVNYWDSTLAVIPMDPMTGALEGPIKHMYDPKHGQKMLAAHGGCNHSNNDDSTIQMRQADPHSHALVLDPFVGTVAYVPDLGKDLIREFYYDSIEGKIGMEMNILPSGLCTGKPDGPRYFQFHPKFNIGYVVNELSSTIAVFEVDRKLLNEIHEASKYGEDMTRFKGRSTLRLVQSIATIPSAFPNLLNTCGRICVHKNGRFVVVSNRGHESITVYKVKMSGCKRGELTLVNHFHTRGECPRHFQFDNSGQYLLVANQDSDSIAVFNFNLSNGDLRYSGNEYRVPSPNFICCCPTRDDDTPTPPTPTEIQPVVVERESGNASDSDDSTMHASRIMRKNGEKQLMDELDKARAEIAQLKQMLEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW93</accession>
    <name>A0AAD2PW93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosducin thioredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25993" checksum="21A53B03A9FFEBD1" modified="2024-05-29" version="1">MSHIECSHDVKPQSILHHIGRLGFKIAKPIANRRKRTRMERTVQKGSMKQSVAQSVSDTMESSEDGSFQQEDYHDAMNGEEDEFSLSFSDFEVKEECRGIFETLDQNEFLTECFVANGRSDIVFLVHFFNQGTFISNAIEDVLSKRVRETNSKCECRRINSTHAPLSTIKLQIDPEQPTVVAIKNGKVLGKVSDISSSECTELDQWLARTGILQKVATGESFSGLSTTMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXV8</accession>
    <name>A0AAD2PXV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002380">
        <property type="protein sequence ID" value="CAJ1968417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029059">
        <property type="entry name" value="AB_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12695">
        <property type="entry name" value="Abhydrolase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-5" evidence="2">
        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="284" mass="29852" checksum="2E937ED951F1DF86" modified="2024-05-29" version="1">MHESKIGVVLYGGGLVDPRGYSVLAERLASRYGFHTVIPIFAADVAFAFGTCDSGRLDMAKAEFPLVEKWVLAGHSFGGVSAVVDSWSRFNRGDEALGGVALMAADIQQNLGCGEIDFSNSTLPMTSISGALDGVLNMTRYAANQQFLSPATQSLDIFGGNHGNFGSYDGSERVAVLGPGQNDGTSLIAPEIQWDLSVAAIAHVASRMGVEMPIKLSMEEDDTMMNNDTSGNSTTECDCPSLGSNGTNSSDTSTAFGLSPAGGATMSNPIFLTVLLLAWLFKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY09</accession>
    <name>A0AAD2PY09_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma carbonic anhydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY09"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04645">
        <property type="entry name" value="LbH_gamma_CA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047324">
        <property type="entry name" value="LbH_gamma_CA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050484">
        <property type="entry name" value="Transf_Hexapept/Carb_Anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061">
        <property type="entry name" value="DYNACTIN SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061:SF29">
        <property type="entry name" value="GAMMA CARBONIC ANHYDRASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="29837" checksum="0902505817A29A9A" modified="2024-05-29" version="1">MASLSTRVAVAASGAARRMGAMLDGLGANIEVAKYTEKLVPSTRFIAVDGIAPAVGGSNNFVAPSASVIGKVSIGDHSSVWYGATVRGDVNNVTIGTRTSVGDRAVVHVAKIQGDIPTSIGDNVTIGAGAIIHACTIESLCMIGESAQVMDGAAVGTNSIIAPGAIVTPGTKVPSGELWSGSPAKKERALTSQEIASIAESAHEQLELAYLHSVENSKDYKQLIAEEEDRLDREVRGKGQGAWFDPNIPDPDDVLGQGSPGRIFNSTLTHPEEGLKLRAEQREKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBJ8</accession>
    <name>A0AAD2CBJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1923995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="372" mass="41058" checksum="E2D9AC42C7AC7BB9" modified="2024-05-29" version="1">MGIIKIRANKPTQDSKMGIKYLSDGVGMTITGIFENSIFESTNLKVGHEVIRINDSSVYGKPMEWIRLKLASIEGEVELDVKVNEDTKNYIQIRATKPSPDSKLGIRYVPGETSVVITGIMEDSIFSSTALKVGHEIFLINGTPVAGNGRDWVASMLYSIPDTIVFDVKNTWTAGVKLISVGKKAPTGNTRVGSSDDRVRILLRCVLDASRSEPPLFFVGHGIPIDEWERIYDIIEGDLVPAIAESRLIDDVMRKEMGVYRSKQIVKGYMDIGESQHEAKVFKMTQSASAMADTCTLVATNVLSHVSSIMAPYSVRCEIDLESYELPKYSDIKQKQAFQAKRVNGIKFIPIVQRTIPDATTVPPLAVAELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBV5</accession>
    <name>A0AAD2CBV5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000009">
        <property type="protein sequence ID" value="CAJ1926932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBV5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1926932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="471" mass="53089" checksum="28001AC6483B2D52" modified="2024-05-29" version="1">MAAVPPFFTVHDGMVICGIDNVTLFQGRTQAERIAYKIFSDDFTTTMDSTIDKLDEEFKALAGLTIAQGQIRLMPAIKKNIRAFIQWCRDEIRMGRDPTTTPFPVIDAAKLLRRMKTHEQYVYGSKLMSQQALPQDFTNDVQWEDWCPTFKNYLCTIPGRDGVPLSYIVRMNDTGMLTLHKDFLETYINMAPHIGKAYVMDNAKVLVLLSKLIVGNTEAEATLQAINIAGNGREAFNALRTHYEGKGILASDIVKAEHTIKELCYVGEKPKMNWSMFEQMLKKAYATCDKHEGREVHSDAMKLLREKFPQGTSNATDRGRYLGETRTDNNRNRSRSQNDGGGNKRRDKEEITLSNGEKIWYHPSYRFSWTHLQAFTKKQRKRMAKERAAYRESQGLPARRATGQAAQAQQEETQLAELRAKVASIRSNNVPATISAKAATQISQVPVTTTGTTAMGGRNQQANNQQASGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEK8</accession>
    <name>A0AAD2CEK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000180">
        <property type="protein sequence ID" value="CAJ1931766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33240" checksum="45D30862DC4D629E" modified="2024-05-29" version="1">MTTTTSHQPVLPPLYFDNVKAPKTTEGKRDCTTSDLPAEILSLCLTRFADWGDLAKLAQVQKSWSSILDDAAGQSTDMKWELSQALLNGTCGLERNPKRAIAVMRELTNVNISDEFEPEVADNDAVCFAPALRAIANCYFEGNGVEKETKLGLAWLKAAFELGNDVDAAYETALIHEYGHHRVHVDVVAAAEWFQKAAEQNHVEAMSELALCYELGCGLEQNDEIALDWYTKAANLGHITSKYSVGEAFEEARGVPQSDEEACLWYYRAALAGDEDSKKSLRRLYDIARIVVPGVAEIFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF30</accession>
    <name>A0AAD2CF30_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spore protein YkvP/CgeB glycosyl transferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF30"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055259">
        <property type="entry name" value="YkvP/CgeB_Glyco_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13524">
        <property type="entry name" value="Glyco_trans_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spore protein YkvP/CgeB glycosyl transferase-like" evidence="2">
        <location>
            <begin position="433"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="566" mass="64219" checksum="E15BB892AA30A0D0" modified="2024-05-29" version="1">MMYATPHKSSSHNGSTTLRQTPSSALSSRSSSTSSSSSSSPPSISTPSSSSPTLQSLRLTSPRKRIIRPLHHSNHHNTQYSLSSECLRLLTKSNKLLLGIASLLVTWLLTASPYERMALEKLTRNYDIPNGYYDHSFSLQQQQQHSNNPLIRAKRGLPDNLLLLKSSSSSNSHKKNHNLRQRTAKEEEENKVPDVDVTPPSRLRLSPEPFLPTAQTQVHFLADATTPDRTSKFILDGLERSSYLEITAISIAQLHATERQLASLQVFERKSELPLLYVVDWGSMDRDCGLLHTMLQKTSISRSDSILLMDFSASHRHTKCAFLDDYKTKYTKRSVVEKRYYDMTFNWIYPGQLMENEGGDVVHFAPLVLRESFVDLMHNVTTSKVQPLERTNDLLFNWKPGDNSHFGFLRRLVADKVQSLGANVTSFAGSDQGYVEAMLRSKIIVLAQRDEWEGHYRLFEAMASGALVLTDPILAMPPHFQNGTNLVVYHNLEELKRYIRYYSSDKRTKKRLEIAQNGYATVMGRHRTWHRMEEIVFGTALTSVDQLDGQAPTKQERPDLTLVEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF34</accession>
    <name>A0AAD2CF34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-adaptin appendage C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS836</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Adaptor protein complexes are heterotetramers composed of two large adaptins (beta-type subunit and alpha-type or delta-type or epsilon-type or gamma-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1919089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000002">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000012">
        <property type="entry name" value="Beta-adaptin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000002">
        <property type="entry name" value="Beta-adaptin-like protein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="12">
        <location>
            <begin position="766"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1919089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="883" mass="97593" checksum="6E7799CACBF5C494" modified="2024-05-29" version="1">MPKGKDSSNANDSRFFTTQKKGELHELRMELHATEKQVKVDAVKKVIASMTVGKDVSSLFTDVLNCVQTGNIELKKLVYLYLINYAKTQPELTLLAVNTFVKDSNDPNPLIRALAVRTMGCIRVDRITEYLCEPLGRALRDEDPYVRKTAAVCVAKLYDIAPDLVAERGFLETLHDLISDSNPSVVANAVAALSEIAEASGKDVMKISAAVLQKLLAALNECTEWGQVFILDSLAKYTPADGREAEGIIERVTPRLQHANSAVVMSAVKVILSYMELMGSSNSDAIRALTRKLAPPLVTLLNSEPEIQYVALRNINLIVQKRPHILENEIKVFFCKYNDPIYVKMEKLEIIIKLVSEKNIDQVLLELKEYSTEVDVDFVRKAVSAIGRCAVKLERAAERCIGVLLELIQTKVNYVVQESVIVIKDIFRRYPNRYESIIATLCDNLDTLDEPLARASMIWIIGEYAERIDNADELLDTFLETFEEEDPAVQLQLLTATVKCFLKNPEDTQDMVQRVLDLATEESDNPDLRDRGFIYWRLLSTDPEAAKMVVLGDKPVIEDDIFKLDPSLLNSLIGQIATLSSVYHKPPDAFVVRRAAGTGLGGDEDDDEDDYEAENDVGGEDLLDIGGMGISDGGLYEPKAPMNKVVGPEKSNGIEVHAGFRQLNGTIRLEMDIQNISSQASVHGLAIQLNKNSFGLSPASQQIVCNPPIPTGGSGSAAVELVVTPSMLAPMPPGQPANPQVQVAIKNMATGNVFYFAVIFNLDALFSQDGTMERSAFIETWKSIDDRNELYGTVSDLPPSNVDIESVINKFKGYNCFFIARRPVPNAEGQEVVYFSMRTVTNMEFLAELTFKQGVNATKICLKTEKAAYAPLAKAALESMLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFG5</accession>
    <name>A0AAD2CFG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="94"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="437" mass="48684" checksum="9CADAB8D9D15F5DB" modified="2024-05-29" version="1">MRSPFRSLLTSALTTYTGGGGGGGGSAHSKRCLSSLVSLQEISIPAADGTIMAAQRWTKQQPRQTPATTSKTTTDSENDEKSSESSSQKFDRRTILCTHGWLDNCGTHHYLAPRLALELEDGAEIIALDFPGHGHSSHRSKDAPPLVSADLVYYTCEAIRALQSPSFSFQASEEEEEKVNQPEDFPEKWTTDSASGSIVDTTSDNEKKKITIVGHSLGAAVASLTAASFPEWIDQLVLLDAATFLPRQATDTAEHVRQHILKRQQHTNSQDQQQQPPRVYPNLERAIQVRQFSATKMPGNQAMSHQAARAMVMRGTRKVVDSQQMEEEKKDEVETLDSMDDTGPVQFRHDPRFTWPSIQYMTWEQNEGIMAALHKTDIDVCLLQAESGWPVDDYITKRVKEILQPTFFRRLPGKHHFHADPETAEAVGDAVIEFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG33</accession>
    <name>A0AAD2CG33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS2389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000147">
        <property type="protein sequence ID" value="CAJ1931437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="8">
        <location>
            <begin position="614"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="783"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="783"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1931437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="814" mass="89836" checksum="8B46249B0156BA8D" modified="2024-05-29" version="1">MGKSSKQKDDDVVVAVQKPKLQAVLLADPFLTPQQGKAFKPLTLDGPKMLCPLNNMALIEHSLDFVATQGVEQVFVVCTQDEMEEYLQETKKMVHFAMELVVIKDTSLTNAGDALRELYKRNVVQSDPFLLLFGDCITNMDLGSEMHGAMKAHLDRRSKDSASLMTIILKEKPPSSPSAVGTGPATDDLIVGLDSDTNRVLQYDNDANNKTVKMPCSFFKVHSTIEIRDDLMDTGVCICSPDVLGRFEDEFDYLHISQDFVHNSVAEEEEGLQTRIHAHVLPTNTYAARVLDEATYHSISSDLLRRWCYPVVPDNYHQSRTDDANSLYAKPRRRYKVVSQVQHPPQLFTYREITHPSKVGRNGTITGPGMLGCGGSIAEGANVLASVVGNDVYVHDNATIQSSHLWDNVEVGANATIIESIVSQDCVIGEGALVKRGCVLGKGVVIGKGAIVPEFTRITLQEDDEEDEFGDDGDWGDDTNINNGKETDHAQSTDAGQGNDESPQTAVNVVGKDGSGHVWVYTHDEDDESDDEEDLVVTSTDTMKMQSIGYDPSLYWSKREEYQAEPEDDGLSQGGGPTEDEQMDAHAFSMMTDDAFTFEDIPTATTATPVVFGRQKGVDVVKEMKEICLEFEETSPMENLAIELNSYKFSQNAAYSDCTRASTLAMVDRLEITADMKDGKLVSSLKARLEFWGPLLQKMSIGIEEEKSILYGLEQVAIQENSPVATKLSSGLSFRFVLQTLHDEEVLSEEAILSWAAERKEEPKDSAVGNLFQLKSIQEFLEWLEEEDEEDSDDDSDESGSASGLTDDDAEHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGE0</accession>
    <name>A0AAD2CGE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000236">
        <property type="protein sequence ID" value="CAJ1933071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGE0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="150"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1933071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="349" mass="40164" checksum="E973ADA3FDF30154" modified="2024-05-29" version="1">MMTTLRSERITNNPRKASSKSPGRSRGLHSRNSTGRAAQRHHAAVISSPVAGTTTARARKSSPLVLSSPLLSSSLDVASGDDWSQYSGDQQSEVECLSRLREYCKLFQIPASDSLIFRFACFYDFDYEEIRKALKNKDYTNPYLSFDKMDDAMVKQFQTGMLIPLPKMRTKKQKSQVIYARPARYVKSPEAFDDLLKQLCFLLNDLSRSAQQCRHGVSLLINLKGYSRKNVDVENSIRLVQLIQSHLVPTKIEMVIFVDTTTMSSKVWQNSISPLLSPVEEKKIHFAKQDDLFRYLMPSYEKFLPDEMAEGWKNTTDLIDNYVDRKIRIEKEQREQEQQAEQQQPEQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGY0</accession>
    <name>A0AAD2CGY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGY0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="117" mass="13078" checksum="801205D7E1E1573A" modified="2024-05-29" version="1">MQQKDLQQSGEKDITVEAILAPTSGSPNDPDDSDAEEEVLLCPLELDAATVTAGLAAYEKLLWKHGMYKAASAAQYAREEIFHERRNAKQKQLINKRKQDASNRPQSILPNKKTKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHI6</accession>
    <name>A0AAD2CHI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS3770</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="10">
        <location>
            <begin position="517"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="11">
        <location>
            <begin position="744"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1934430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1153" mass="129008" checksum="5C8C0F2D2FB1A871" modified="2024-05-29" version="1">MPYAGTNSEFSLPMADDDETDDKSSNTGHTPPDRRPSQSAEIAAKENTQVRYSRLLVMFVLACSALGVGYLTFSFVTNEEEDGFKTQFENDADEIASVTGTNEGNVGTLLGILSLIISSWSSNAGTSFPNFTLPDFEQFASGTRSLTKSSLLVYTPLVEHADRPGWETYSMENQKWIDTSLASVGKPNSTEQISEFIYYRDSRDQLRETTLPKYSPIWQMSPPPEDVSVINFNLLDNPIFQRLVDFTTTERKAALSEVLDPRELFGTAVPEIASGEPQSIMVLAVNKEPYNPQSPIVGHLVAVFPWSAFFDDVLADSKSSSGGIFAVVEDSCGTAFTYSIESGTATFLGMEDTHDRKYDYLKNDDQIFLEYNSTNTEGVGQSCVYTLKVYPSAAYEESFKSKTPVYFTVGVLAVFTWVAAVFSFYDCLVQRRQEKVNTFATKSNAIVASLFPAQVRDKLINEQREPKRRYKTGGKVSAAALNATNDNEMWASQLEAGEHGGIDDDSPPIADLFPSATVAFMDIAGFTAWSSQREPSQVFILLETIYRSFDKIATKRKVFKVETIGDCYVAVCGLPEPNDDHAVVMARFARDCLEKMNELARKLEATLGPDTANLAMRAGVHSGPVTAGVLRGDRARFQLFGDTVNTAARMESTGTKRKIQISQETAEMIIAADHANWVKPRQDIVVAKGKGEMQTYWLLPQRELTVSVATSTQEDSEGEDLNAMMWMKSNKDDEAKANGEATSSTPELNGKVQRLVDYTSDILLQILKKIVAKRGPTDKASPAMERRLVALEESIGKAGICLDEVEEIIELPSFDHAAYQAKDVEVSQEVVSQLVSFVKMVASMYHFNPFHNFEHASHVTQSTSKLLSRIVAMKHIDEVQKLHDHTYGITSDPLTQFAVVFSSLIHDVDHRGVPNFLLVKEEPALGSMYRRQAVAEQNSVDVAWNLLMDPSFTELRRTLYSNVSELRRFRVLVVNCLMATDIFDKELAALRKARWDNAFFGEHKDDGSQLSINRKATIVIEHIIQASDVAHTMQHWHVYSKWNERLYAEMFTAYCQGRSNKDPTQGWYEGELWFFDNYVIPLAHKLKECGVFGVSSDEYLNYALANRREWEKKGKMIVASNFEKFKKALDNRPEMTKSVSMDGDMAPLPNKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIA5</accession>
    <name>A0AAD2CIA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="67201" checksum="F0348DD2C7DC33AF" modified="2024-05-29" version="1">MELLAADQSNSSSMIIVSEEAASAVALSSWIPIDDSLGIWTEFRHTDAGTNTTATTIYDDADGHNDEQQHHQQQQQQSVASVVSNHRHPYYYYPTTASSSSIHAAGSDLRDWHDDVTSPIQNRSSNNQTTTTTTTTTMIAPPQYDDYDDVASAVDYNPALAMTTSSLSFESATMDTGRMPTKHHHYQHHREEAEEEEEVEPRQDDPELQIISSQTPESPSETPASSHHRRTSSGSLWSGIVKAEISGEMIEDTVTGTADNNKAGDENGDSNHHDTPTTTTTEKESSTHSFFRSFVDTSFPNNNNSTNNGNNDNSERDTSPNPLRVLSEFMSFDFLFGSIPTQEDLRETMELTRNVNWELGMALKQETDGDNAIVIASSSCSADKNNNSNSNSNKNNSSRSSSHIMSKLGYKPGMQVVKINGEACPDSLSELYAQMELQIEVMDEVTKETKVAIVGAHEPKLDLYVHKDSKRSKLMYITKVEPNSVLADAGFEAGMVLTRINERKCPVSFSGLVRLVTAHIVAVPKDLAVPIGLESNRTISNLSLPPKEEEDGDDDDEEDELRPRRSGGHQRGIGSSRFCSSRSPSRRSHRLLDQKKSRWLRGGLVAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKC0</accession>
    <name>A0AAD2CKC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000447">
        <property type="protein sequence ID" value="CAJ1935310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF119">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="260"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="671" mass="78431" checksum="A1309A616395E113" modified="2024-05-29" version="1">MEFAEHSSELRGIFGPKGDSLNWLKATKKFPNGVPRFETRDECLEFMRNYNKENGGSNPEYPQLKHIFTTLITWDQVEEILMPAIKKARKEPSFAKKVPRDYGKEPDDSSKNIYEQSGGKEAVDAINFRLDQPFHKCTTPESVINTMKYLFFHMKCGIYVMVRNGELRIFCPFTNSDYRNTWSETLKIEGDGTLDKYYTQKAGLYREENIEKDMSKWWANGNIVCNELSKDNDTSKMQHWGDQFLSPLRDMLAEACRLRQIPDCEFFLNKRDYPQLKVNVERGVPVEPYGFIFDKDDRDPNQDVDLVPEHKFKTYAPIVSFYAAAEDRFTDIPWPSSEDWEGACGLVFPQTFISFEKDTEGYPVFGNPRDLFTEANFRKFQRGWDDNRVATAFFRGTATGGGTTIDNNQRVKVAYLSHNWKNDPEKGGEEPFLDAAIVGWNLRDKKIAERPMTFLRPKEFDFTAGRQHFTPIYEQSKYKYLVYVDGHCAACRYGFMMRLGSVILKVAPRQVADRMWYFPLLQPYVDHVPVKSDLSDLEEKIRWCRENDDKCREIAANCTKFYEKYVARSALLDYVEMVTKHIAKRQIEPPKWWEAPPRERPPPTLNKPDMKCFDDRSSGVSRFCARCQEDIDKEEVELRENEAKAKAEKKSTKKKKQTLRERMRKRAKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKN3</accession>
    <name>A0AAD2CKN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000379">
        <property type="protein sequence ID" value="CAJ1934752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKN3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="119" mass="12953" checksum="7B11DCD44403F01E" modified="2024-05-29" version="1">MEEATNVAYHPSYGFSRTHLQAFTNKQRERMAKGRAAYRESQGLPARRATGQAAQTQQVETQLAELQAEIASIRSNNMPAAIPAKAATQISQVTMGTTGTTAMGRRNQQTNNQQASGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLF2</accession>
    <name>A0AAD2CLF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000746">
        <property type="protein sequence ID" value="CAJ1938622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1938622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="290" mass="31114" checksum="EF5CCAE7F0DDF0F4" modified="2024-05-29" version="1">MQSQKATKQIYVKNSTALSTKELKSCKIYGVAWFRDFAVKTKAYAAIASTDTAAQNKFKDDIFEAVLATGFLCNCNQTRTAPLMLDLQTNYCREVDYYPKTVSKAQDMLKIHMEVSENPGVNLYQGKDQPNKGKGKGKGKGKPKDGKKAACYVCGNKDHMSPKCPDRLLPKTQWKNQDQYVDYGKKLNLNQIGATVPATVPAIVPGASASTSGASSVAGSVNTPLRLAGTTGNQMMQVPSGMQLMQIPTQGGGTVTVPYSMNANGEIASVECNSANKASVVLKCAKGSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLH6</accession>
    <name>A0AAD2CLH6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1938074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="330"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1938074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="722" mass="80791" checksum="85C707F8C22C5F23" modified="2024-05-29" version="1">MNQSHNATGHNGIGTDDGFESPIGMMNALKTGNPQADMAIAMFLPFLFRLVFSSFGSVDKLQQWTIWRKLMFWKKTEKMDKRFIIHRTSRYSWGESFDVDENTKNSLLQKAIKMYIHQVLNVKMVRAHMDLTQLETSSASNDDYCCYYSDDEEDKDEGLDDDDDGEHGSKRTIAGMLARYKVLNNLPQQEWHELGTFGNPAGVVKLLISIGKGLTEEGSTFVYDETYFQLTSPVKGAIDSFVETAYSWYLDELRKQETNARHFYEMQNPESNKQKSERGSKSRCTKFKRYKLSEEKSFDSLFFQEKKRLLGLLDHFVNKTGKYAIPGYPQKLGLLLHGPPGTGKTSLIKALAQHTGRSIVNVPLSKVSTNSELMSIFFDRSYGIQGSSVSIKLGFNDVIFVMEDVDATTSIVKRRDGRRSGATDDSTVVRLPIPKSLWRMFLESSSEDCKSLTKLLISKSEKLKEDAEFQRPEILRSVNQRLADLPALGLVDETRDDTAKELCSIALEVATKSQARFKKLDDILAFHAKSIKSKIETGIEVDDQFAEELLEEMDSVKLASSLSSASTHDGRPDKTGKSSSKSSLLSSFLKPNPDALSLSGLLNVLDGVVDTPGRIVIMTTNHPEILDPALIRPGRVDKKLFLGHMSGDDIIAMMEHYFQETLTKSQAALVRVAVHGPSIATPPVLKLTPAQVEQLAAEHDVLDDMIADICKKTPVNFNSKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLM6</accession>
    <name>A0AAD2CLM6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000713">
        <property type="protein sequence ID" value="CAJ1938375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="151" mass="16006" checksum="43CC863323FA2767" modified="2024-05-29" version="1">MAGLTLEGSELCLQCRIVRTLLCQGAFLSLQCIVPNLNIIEGIFQLLLLFLHLVHHSGHESLVESVTPDQAPRTAPTARPPKRDGGTNAESITPSLTDTQGSGSQSDASTPSVFPIFRHPQQSPPSVPVKGKKDKKTSLAGRGASRSTAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP03</accession>
    <name>A0AAD2CP03_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000713">
        <property type="protein sequence ID" value="CAJ1938379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP03"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="166" mass="18945" checksum="BE7945849DF8275F" modified="2024-05-29" version="1">MIKHERRIPLHLWPNRYIANLPVNSLAWLEGRYTLPDLLDPATASFLSHCRFHKGHSPVHLQVSKDDHVYFWLRNPENKGSEPHGLHNGHLKAAIQSPSIAYCDALFRNIPLTTGFVPLQWQNLMNFAIGKKPGDFRLSKMRTIQLMNSEAQANNKKAGRAAMQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ27</accession>
    <name>A0AAD2CQ27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000771">
        <property type="protein sequence ID" value="CAJ1938800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="193" mass="21475" checksum="6F1F05DFACE557D5" modified="2024-05-29" version="1">MACKSFSFCCCKKAPPQASSTLDYWKPSSPKRRRTAVAAKLPAPPPQPSTSAAAKRLPQAPSTESEESTLDYGKPSLPKRRRTAVAAKPHPPPPRPSTSAAAKRLPRSPSTESEESTLDCWKPSSAKRTRRPDIQEGQQSWASQLRMKKELQAFLAVDKSEEVREKFNGVLCNFDKKLLQPKGRRESARQFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ94</accession>
    <name>A0AAD2CQ94_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="249" mass="28014" checksum="5BDF63D1AE945D04" modified="2024-05-29" version="1">MSKSDEERLLLSEPALTAFIVAEMRHFLTSKSNEPGKLTKWEMSDEERLDLKLVDDQGEIINDEYEKAKAGLTDMEAIDLLCNATQLTFYDGYTNEQGIMSALGSAILFFKEPLRGSPKLLAACEIVGLSDYAVAHHITDMYHHRCFRGTYTKTLAPSGEGEIAARLAVGLKETNSQNSEKERTSKNIKATRGADERDEGDECLMWSPTTPGVCLHWKSDEEAWRRKRFERVQMEGTRDPRRGGSGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQL3</accession>
    <name>A0AAD2CQL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000613">
        <property type="protein sequence ID" value="CAJ1937163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQL3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="758"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1937163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1164" mass="128070" checksum="28506049EA5016C1" modified="2024-05-29" version="1">MTAQGNKLGRLPDAHQNRKATGTLSSIKDDERYRLVHNVLLPLVRLLTQCYSILDKILPSQPKPTENTSRKKTKKPEPPVGMLSIQNYTDVACLLEFLVLTNILPYLDANVMISAQDRIQYHLPKSLAGRMPRAALAWNSMQASSISASEKSFELLTTSITISSLVMLDRFKPMLLPRHLSDLYAATFQTQQWEKVSDSQSASDIALLYRTLGLRPTSRLNPVLQAKAYQTMLLRGTKAPAWLRQTVSSLLSQLACTDLFSIIQVFCPTQEAAMASQRLGRALAGTPFKEALVQQMLGLMQGIFPTNGEISGPTVSILETVWAVLNEWSPDTIRSELIELWENGIMDTGTRDGQTIHATVRQIGALFSFVPNVSISLKVLHQIPKSIILPQLVRLGSMSSIFASNARDDAKQTLHWISQAICSVTQSTMIGSVAVSAEGLMAIAWVNSLEPNSWDLSGNEYYIQDLESQFSSIKGFECLGIRKCDASVLDLKRIIEHGTRRVDVLLETTYVVHEQEGFTRLKGLCCRIFHLILELYLSKSTKKTLSAISSMVPILSLPTLFERCSPEDLLFGDSSNATSLLFLIKISLISVDRSHKSTTINEGASTRSESPLAVENGLAEGLFEFRKVVTMHTASQTSSSLLSGLDDKEDFASSLQIAFIMLSLLVSVLEFGSTLRSLDEEEVLHSFSPVLESLAQLDENSSTVIPSYIEESRAEMADVAAYALSLIASRSAPRTREAGQLDSESPYDVLKSIIMQSENDLRSAEPPIRARGIVELGRLARGYLGIIAKENLSSGKSSLINILQDNESVSSNESTINFVVDEILRLSIGAVGDKESYVYLAAVQTIVSIGDMRPKKLIPLVASIVVTGRWQLGSAETDYQSINVTGEERIKLAEALIFMIKRRPVVEEYVPTLLALMTFGDERANHDSDKAEDSLFRSETHKYFITEAKQEAGEYEPSQKELWEEKDIRLKTGGPVFKAEELDVVRAARASVLAALVSKSPPRTIALDCAFLVRLINDTLVLETSRSVCRAIATLALALYESALRELEEVLAALETASAQMVTTRASIPFTVALISSDEEVLHSNLAAKSTGGLAVSQQTLNDPATSARCKEALILRQQAEETGLFSCARIALSQDLSNRDYPQMLRVLKANADMGVKVKLSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQQ2</accession>
    <name>A0AAD2CQQ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQQ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="201"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="285"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="410" mass="47035" checksum="F61F0F3755C0EC10" modified="2024-05-29" version="1">MATNPENQGHMMGAPQMAPHDLGVDQIPPHQHGLASPHPSDVTATSALGFPDPMTRVVQPVPQGQVLPPPMVGAPQIPQGEPPAQVVTEDSLKRSAPSNNNARKPPPKKPRRDSREGRMSWNDSLFELLKFKAEHGHTDVPEDHPIYFWVYTQRKNKRQKEWRQQHNKTENPGTRKLTDDHIKVLNTIDFCWDPYKKSIAERWKQRFDELVTFKNQHGHTNVPQKSNARGLSSWVKVQRMNYTHAQKQKQGEKLASEHCVALSQDRIDMLDSIGFEWRVKKVAQGWDARFNQLLEYKGINGDTLVPFNYVNEHGRLGRWVNKQRHEKTLKLRGEKSQLTDEREHRLNEIGFRWVAPGFQKKTVKEWANPHDGIPEAHADHDVMVPPPHNPAPVGLPHAPHHMHHDSQEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS62</accession>
    <name>A0AAD2CS62_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001229">
        <property type="protein sequence ID" value="CAJ1944681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="303" mass="34513" checksum="950C01D586647C14" modified="2024-05-29" version="1">MSFGSMSYASTSNKPGEKKLRTRMRVGFEVDVAAGTIRQYLHGELRLQGYGAGCYESVLQFGDIEKIGALCFYPQEINIRAMEKELMRHFDWKTVIGLQYEWVNIPYSGRSKWNERSPGCMMWHVYVRSRDAKRADRELRLWLHPSTPKKDFPWCTVTHYISDWKAAQNGTISVKAVGPVKDENLTMISKHNDFMELTKAKYCPVEIPGMLKQATTKAFGPRTCLSMFLSIKARPVRAEKVAAADVNSDSDSDDSLLEDISHKFTKVTVKGKTKIKKQPPKSAVAPTLEHDIKLRNQKSKTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSD9</accession>
    <name>A0AAD2CSD9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSD9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02019">
        <property type="entry name" value="NK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="355"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1942142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="607" mass="66200" checksum="44FD9C1B74E430AC" modified="2024-05-29" version="1">MDNPKKERIGPLGSTAQLLELPTSSIHHTETKPNQITMGYTDLHELAKGWKAAIARATDPATKHETQIKNDRGNLPLHSATSFRAPLEVAEALLEAYPEAASITNNYGNLPLHFTAWKKGPLEVEKVLLKIYPEGAAQKNNHGNLPLHYAAHYNAPLEVVEALYNAYPEGATMKNNDNNTPLDLAIADGASPNVVSLLQGKKVPPTEDELLEKAKRRCEAAEREFARAQEATQGTNDEMEEVLGLLMDIYEGHKHALYSAGINPDNAGTAENMMDQVRKAAAADNPMTGGMDEGFMARNEVEEEAQLIEDALCPPDDLVELALSKIVGLETVKNQVRGLRRTMEVQKYAPGARICPHHIALQGNAGTGKSMVAKTLAETFFDVGVTKNKNFVVCGRDDLIDRKSEARTIFKTRQVLQKANGGVLVLNEAYTLLPSTARPRGRDHGGAALREIARCLPSGNPVVILTGNPLNLQRILSSEIGFKNYFLTRIEIPDPSSASIARMFLSKVGAKGFIAGDGVTVEYLADLISTNTDDEWRAERNGRISDLLLQGVRAEIGKRINFDDAASKVSISPIKMMSPGQSRMPAFSPEEIFITVEDVQNAIVNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSN9</accession>
    <name>A0AAD2CSN9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS9341</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSN9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="571"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="842"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1945197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="960" mass="104573" checksum="20C936507F80CB84" modified="2024-05-29" version="1">MDDYRRKTVILYVSNDNRIDHDEQVCLETSQSQAPNVWTRRKALQAAALGSIALLPSTSALAGVAEFDVSTGALYTPKADMLRGGSAAARGIQVKTSGQRLKPGQKFQNVYETRFIAYLSRFLLTFDSSATAWWIKEADSRPEEERFAEFAESVEIGLADYFSGPYGSYSSIQAAKAGLTAAAQAKSRRADDTQKGFFDLLKGIVVGDKERERRERDSITIGKQGILNLYTLLKIRYTSEEEKLQLAILFSFFSQPELQPTTEIRSLLGEIDNATVARVDLIKPVSPSESTSRSSSQRGGGYTLTDPPIVSVDAPPALGSSYVAAKMKPIMKPTSRVLRIRLLDGGSGYTQAPTVTISGNSERQCSVCAILDRDGHVESLVVLDPGYGYQFSAKNPPKVEISKPKPQKTATEKPRPAQAIVDMEYEVRGIDIVEPGNGYVLKEPPKITIAPPKDDPDWFVETSELTDLEAKYGKFRAVATQMRDKGNRPAYISTKETSRLALDKVRASPLELLPSTMRPELNSYGVYVISSVAAIRTYDTSPNIRFRAMDPLFGSIGKVPVTKDAAELKSGEYLRLALSGAVCTVLVRTALNPLELIKTKLQLKNDDELFQFAEDKMKGEKVTAKAKSKKTKGKATTDESELTESDGNEIGTGDLVKSVIELRGVGALFQSADITFLASLMFGSFGFGATELFRRSFTLTFFTDGGDSNSELILLLAAFAATVITSAAAAPFELLRVRSMGLVESKSWTKVLKEFLEEKGNRANGNGPSNSNEESEDSFWNDLNARDLLPLFAGFPPTASRELAFAIPKFLAFDVISKSFTEFVNANAGAGSLPVQVGVGTEGLLISAFAGALAGIAGAIVSHPADFILTKTSASKKKINEDGTVESGADWKDVVKDLLQMEGGIANLYVGLQPRVVFFFLVIGLQFFLYDYVKILLQVGSDDLSLVLDVFYAVRQGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSW1</accession>
    <name>A0AAD2CSW1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp fold succinyl-CoA synthetase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001336">
        <property type="protein sequence ID" value="CAJ1945303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSW1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="87" mass="9257" checksum="31DF0EA4AA8637E5" modified="2024-05-29" version="1" fragment="single">MFHRLAARSLRSASASASNSSSKCHKVNFQSKRFLNLHEYQSSAIMEQAGVNVPFGIAAHSVEEAVAAANQIGDEEVVIKSQILAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTC7</accession>
    <name>A0AAD2CTC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS9672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTC7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="4">
        <location>
            <begin position="231"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="427"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1945528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62548" checksum="F0A39A8BC46628F7" modified="2024-05-29" version="1">MSTSKLRRRPILFGNPALGTYGGDVYTLEKETKSQQEISAESLEEFKQQQQNEGCNVDSMVALVEVPPDQVTEGILNLARSHRPWILHVRIVIDVLEDGGSLDNNEDNDKTYLILFHMSSPEAADDFCHELDGRPYTFLDETITCKPVPVVALNGHNGVSLLNPLFASKQTTMSAGALGVAGNVPDDFNCAVCLEHMNSKNQTSSPGIFTTVCNHTFHLDCILKCQDSPCPVCRYDHAGLNDALSQCHICGTTENNYVCLICGVVSCVTPLDDGQGSDLLNSSENSTSCQFHDSDKTSCKAIGSPRRVTSRPAAVAASPSSTLHPSRDDDFTARQFNRSCARKHYDETLHAYALDTQTQHVWDFAGQGYVHRLLQNKQDGKLVEVSDPYSMASLERTQSPGLSETQEGEVLHRKLEGYASQYYTLLKSQLEQQRIFYEGRLQELRQEHGIERKPGATKSENPYLAALRQEKRQLQQRLQSLQKKNSKVKEDVKFLKSMNESLEANKPQIEIKIQQAQKQRVESREMVQKYLPALEEKVTSLILQLEQQNTAHLVSQDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTQ6</accession>
    <name>A0AAD2CTQ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001450">
        <property type="protein sequence ID" value="CAJ1945689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTQ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="126" mass="15095" checksum="CEDD7DCD2FC1DF3C" modified="2024-05-29" version="1" fragment="single">MAHDKGVCDLRTYHWKNGEIILDGDLLAGVDLDELWDDTYIPRVNEYKQSDENLRNEKIDQDEIDALLEEAEEFIENYDDEHTKNVEEQTEDRSVASIYERLRRRNDDDEKYQNDEDLNEKIQEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUC6</accession>
    <name>A0AAD2CUC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS7730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="564"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1942004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="74969" checksum="EB668E97E28AB907" modified="2024-05-29" version="1">MGLEEDHVISDQRYHGHFECVICQSIVDLDCLVTTTCSHAFCRQCLKFWLETDKTTCPTCSRDLLYSSNATSSSHDSKSYMMIGCKSVMVQPLSKDQPLAYRLLKSINVKCPLRKTLGCTWSGDYGDLQNHLLSADHDALEQQSPSSPAQQTPDSESPVQMDAEENKAQEQKRQLEKKISLASSLKEEANGQFGTQHYREATSLYSKAISVLSPFESESKEDTGKGSPKTTSTDLIALLTTLYSNRAAAYLQLQEYHKSLEDCDHILKKLDSTNVKVFVRACRAAIQLGQLDLAQKYVQQGLSQKTQNPVLQKEQRRLAQMTQWTAMGTKQLSSQQYATAKSCYSNLIKEAPAAIPFLLGAAQADLGLGLTDSALRLTKRVLTQHAQNPQGCWVRGQAVFLMGDLKVGLKLLQEALRLDPDSAEIKNSFKAAKKVEQSIEGAKKKMFSRNFQEAVDLLTSCVDIYKPLPPKSPLYANLLTQRAQAYLRLKEYKNCLKDCSLVLYAQEYNIPTWLIRFQAHHGLEDHETAMEEIKDLLRRLPQEEQLQKAYVKADFLLRKQKRVDFYELLGVSSLASEMEIKKAYKRKALELHPDKLPPGSSEEVQKKGQQQFQLLGEGLEILCDDFMRKLYDEGYDPEAIRERVEAAKQAAHQHRGYNPHHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUZ0</accession>
    <name>A0AAD2CUZ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001424">
        <property type="protein sequence ID" value="CAJ1945443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="34410" checksum="38DBC47E72F31BDB" modified="2024-05-29" version="1">MSKRTVDNKSKQEGWIDWRTSSARAKLLEDLHNGTLPLEATELTAKNAWVFYQNKEGFENVVFAQFKARLADHRKQVKDKKAGVTGNKKKGWIDWRSNAALKAKNTITEDLVQGILPLEENVIPVEDLWTHYENEAGFEKVCFDQFKERLEAHREQVKTTLARSRYEEECLRHDRILFPREEVDDNGIPFFDLHPAKKLLEDDVAANKHASMKPEQLRQTREEYKVFPNSYFRPRIYQAVRKLKFINYLNYAREVKDKMLRSKQKINNEEEIDDIRKELFAVRRKKQKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWC2</accession>
    <name>A0AAD2CWC2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1939079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="195" mass="22014" checksum="31D4D732101EFC03" modified="2024-05-29" version="1">MRNILDKVYRELSVTKTLMAEREELRRDQEDFESRASAIQHEYSLRGHDSSHVDNDNNNNNKINNQEHLRGSEQRQHHRKMLADDDGPPEGPISFNRESAMFEAVSDMDQAFPILDNATISTDNTTATTSVGNGMSSQLDVGAWLLMVLVVGFAVFGVVTYRSSPRGRRRRGSNDFHYRSVTLPVVAEDDDWGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CX38</accession>
    <name>A0AAD2CX38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10313</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22104</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001635">
        <property type="protein sequence ID" value="CAJ1946172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CX38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="235" mass="26501" checksum="084F867E37F74D01" modified="2024-05-29" version="1">MMPDKRNMDVSEKDDNTTTAVSPESILYARARNRLLDAVAKRLVETVEPKTDPLVEQVRDQLPKEAEDVRKLPFYNSTLQSLQYQRDQYFMGTKYAADKQAAQQEQRQQQLQRRSESYDDDGENSLPFRRNKPPPNPLKAHYDPTSLASQQTIPLGASFLPSPLVHNALLPIVVGLPNGALREPILNATVNSIPMAQPALNDVVKNTMIQFLSNPHWKEVVQNQTNKTLIGSNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CX78</accession>
    <name>A0AAD2CX78_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001709">
        <property type="protein sequence ID" value="CAJ1946509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CX78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="146" mass="16707" checksum="008AC82DC54B72BB" modified="2024-05-29" version="1">MSIEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDALSLHNEPSREQHDDENTTERSNDASGHKSNFLDIPFFKLPCLQQAKVELPQSPCDVLAGSFIALKHTLLKPHWFQLFYCETEESKAYEDIGIFHELLGFVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXC1</accession>
    <name>A0AAD2CXC1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXC1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="591" mass="67721" checksum="A1EFF7D21CAC5CF6" modified="2024-05-29" version="1">MTNYITTFVNQESLKSISFPKLPRMSAITQQQQQQQQVQETIITGLVCAVAIVLLRYMVLDTYRAYQRLCRQWKRRQPPVSILRRPEGGSRKKNQSWLGVFIRKPNRVRFAKIFRRTFVPNEQELQSRRECWGLIQWRIQLHDEVLPEIENTVRFVPHTPVSILRPSRQDWGSPKPTSSIRVHFAPKTRRRNFLPDEQDLQSRRQLIRQIDRKIKRRNARRWKIDFKRTVLATIVEDPAEEDLSDIDSSLDTGFIDGKVDSEIIAIALENHRQMLPTVLHDMLSNIPVPMDLDDDNDDNDNEPCMEEQALMSLKRTATSCLISSRPTKRRKMNSSSTVPTCAATWAKRTNELFTPLLPVIIEDPEEDGDESHIDSLLEAGFNDDIANEPSTRLAKADAIWVNKSEEILAEKANLNKMTKAERAKWANKARARRSKGQKEIDFEPTLLVIIEDPIKEEEEDEVDDVNEKKEFKPSLHVIMEDPEGEDLSTIDESPLDAALIHDDFDSLEDGSDGEIFGAPTEQSDNAPTNNDIPSDGMGSGWTESGKRYSRRLQLKLSPEKKDPSTEALGSGMTEKGRRYSRRVVNRGKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDC9</accession>
    <name>A0AAD2FDC9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Plastid light harvesting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS3233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000258">
        <property type="protein sequence ID" value="CAJ1933270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDC9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042002733" description="Plastid light harvesting protein" evidence="10">
        <location>
            <begin position="16"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1933270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26910" checksum="D2791C0C9C487410" modified="2024-05-29" version="1">MKTAILASLIASAAAFAPAQEGSRASVAVQESQADLEALAGKLNPVVKYYDPLRLSSWNLWEAGDAETIGFLRHAEIKHGRVAMFAFVGYCVQSNFHWPWPMKLDGTPFPSTDLSPPEQWAALPIESKHQIITFIGFLEVYSELASSLSTTEGQAHYMKGGKPGAFPAFGAAIPHPVPFNLFDPFGFSSGKSEEAKAAGLVKEINNGRLAMLGLFGFLTEQTIPGSVPLLTGIVKPYEGALIAGKDFTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFN0</accession>
    <name>A0AAD2FFN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000444">
        <property type="protein sequence ID" value="CAJ1935016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41473" checksum="A89E8ABD1BA9000D" modified="2024-05-29" version="1" fragment="single">MSYTPRSADVYAYDPALPPTNVPIVSGATAYDCPQSGNTFILIFNEALYYGNRLDHSLINPNQVRKFGIPLWDNPFDEMRNIGIKTKPIFVALKAKGTKLLFDLRAPTDQELANRPHIDMTSKVPWNLGTVQLGKVSIVHEDPIDDPRSNEAELRQLDPIMQGMNEWRTVQQTIVDGERFFQQVGRMDDDARFADVPVRPSFVSTEQHTKATAENLSERQGIGLHRARATLRSTLQRGTRSAILPLARRYRADRMFLRPRLKGKFSTDTAYFNHKASQIYFHKSGFYSCHHLSKVDDKQVGPTLKKFIADYGIPEHLTMDGAAVQVGRNTSFMETINRAAINYHISRPYRPEENPAKGGIRELKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG17</accession>
    <name>A0AAD2FG17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1926452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="252" mass="27303" checksum="CAECE597E6205FBA" modified="2024-05-29" version="1">MKAPSRIAKSVVITNLVNSIRDSATEQGGGGFVRFDSSSGLWYEVGEKIARDKVGQALRDAARLQSEKRKSITIDSSSSSSSSSHPHRDDGRFPLAEPSITPSTTPDNTVAMVKQERSGQSVLKWTHNEDSERLSPSSAPTIAKNDSGADNNSSSFWFRQNTTAMPRTRGTTQHSSTTDEEVMAAFAESLEGDISSHNQRHQQQARTGSPSIMLFSSERVLSPLPSSSIPSSSSLEGIEAADALLEWFENDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGJ7</accession>
    <name>A0AAD2FGJ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000768">
        <property type="protein sequence ID" value="CAJ1938782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="286" mass="32097" checksum="48C39A9ACD5CD63F" modified="2024-05-29" version="1">MTEAMGYGFECLSALESQLVTSQCFCFVNNAHVIEAGNTVHHLGEAICAFVQDTATLWGGGIRATGGATNPKKSFWWLIHFDWDSRIGTWKFCGKKAVAPDFDLQIQGLSGAAKSLRCLKPDDSERTLGVMLAPLENLKADEDQLLAKAKDWAEQLWPNLLHKYDVLPLIRLTIMKKLEYPMGLGLPHPFGCQVFKHLKMLLQHMANRSKTGDYMEANFQAHQLETGTSFAILQQVYNNTAILASDLWMKQCGMNLRVWTSMSLGTPQPYHIALRTILCWWISSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGV8</accession>
    <name>A0AAD2FGV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS5881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="171"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="367"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1937914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="559" mass="62031" checksum="9D5A762509548B36" modified="2024-05-29" version="1">MSHQEDENGGKNMGKASLRVANYCNKNSPVGDESNPHKMKVLLHRLGKKRRMPGFSGLDGDGDDDEGTTDAEVIASKKTRIIADASSIESPPKSSSEPKSPVPANKPKDSVSLAPASSNNEDKADPSTSVSLRSASPPQQRGDDHETTITRVYIDCATLPDPPRLELTESFVEKVYNMLEQIEFNAQSHVVSFLHHGRAFAIHHDKMFVENLPKFGLPQTSVEDFELALMDHGFRQIESECDKGAFYHELFLRSRPGLCVNLRSNATSAQNAKRQHPPEPNFAEYPPVPPMPFRGTEIHVMPRGRNPMAHVMTPHLPMPTVFPVRHAATLYCDWAAWPDPPLPMNPRGLEGHLSLQLHGVLQQMHLEGNSHIASFLHHGRAFAIYDQVGFQQAVMPRFFPSLTFQEFLRNVVDFGFAQLRDGPDAGAFYHELFLRGRPGLCVNMQRRAFPQPFDKQHQLNFQDYPPMPVYGGYPPFPNMQPPNDLVVAPSVSTPKNTTAAQPIADPKQTAPHSEMTTAGKNAKRKDTPTMSQEEIGSPQGKVTEKSHAMEKEASLVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH00</accession>
    <name>A0AAD2FH00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1930991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="207" mass="23027" checksum="ABD9149906D049E2" modified="2024-05-29" version="1">MNNKEETTADCNINTANLSTFEGNGKDDLNRYKRRGALAAALLVLGITVVVLLVLHREDDSNRTTGSFTIGNDDADNLRKKAYEGMQGAAHQLWNTSHDDDVGPNNRDWKEEVDKSLKERGLYLNSRNATYLLNARGKTLTIGDDVEIREFDENEERDCSELPLQGVLQAMRKVGVLQYKSPDTVAEWAAWQGCLIRSHAGTIMVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHW0</accession>
    <name>A0AAD2FHW0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001088">
        <property type="protein sequence ID" value="CAJ1941837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHW0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="294" mass="32971" checksum="51E7876DD7785342" modified="2024-05-29" version="1">MVAELGQYVHAIGTDSNNSMEPQSIKAIYIEPTKGQCTGHQVLNLNTKKMISRPKVIVLPVTDQVIKRVEAWAAAEGVASMEFFDKKRDLETFQDGDQIAGVDDTEQGYLEEAFDQDYEPEDEDECDFNLHGQFDDIDDSEREELLADADNDVNDMPELTVRFQGDDDYESVDDSGDEGDEEEKPIVADLDHHQENIDRGTDDIGSLVTDLEVLQEPPEEEIVFEPETPQVAKVTQSGQAYAQAAMSGLNLSQVPKKPKEWPSSRSGSSTNKNKNRVVTRRKHQEIDLKPLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJB8</accession>
    <name>A0AAD2FJB8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJB8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="196"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="278"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="345" mass="38915" checksum="4FC4B9452F806152" modified="2024-05-29" version="1">MNEGNQGNLLNLYVSAHKQQFSFVNCYLDRASKHHHQQQQVQLLQSLIQQDERQRSLVPIRNQWNQPLLQPCGQQARPPFHIGSILPIGNTISTSAVASLNSDLQSQLLLSLADPPPRRMSLQTLEEEREQARHRARLHQISYTSSIDSSTRAPLPSLISNGAAISSDDSHDDQDRPGMVCASSPLAVGRGRAHADSTWESRFAELVEFNREHCHCNVPRRYKANPKLGVWVCSIRQQMARGTLKNVKVERLNEIGFSWRVIAKEGQQTTNHQISKMDNWIKNFQLLASIKGSVGKRSVPASNRKLCKWVGRQRGEMKGGTLSIEKQEKLNSIGFQWKPVNVLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJF9</accession>
    <name>A0AAD2FJF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS9260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039633">
        <property type="entry name" value="PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31906">
        <property type="entry name" value="PLASTID-LIPID-ASSOCIATED PROTEIN 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042129063" description="Plastid lipid-associated protein/fibrillin conserved domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="4">
        <location>
            <begin position="42"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1945116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="226" mass="25394" checksum="424D43B71A645577" modified="2024-05-29" version="1">MMKRTLIIATCMAATATAFEFPQFPFAPAAPKASPQVLLQELDSLIQQSPKNGLNTPGDISEQILDVCRQLEKQNPTRAPVKNSKMMSGFWRMEWTNFAPAAPSSGKLGPFVGDVYQDVDLNDKQKARNILRVNFPPICGELVASTNVVDDSTLAITFQTVGNKIGGMIPLGPKIDFEGRETRLWEHAYLDDEYRILYARRQEEEESRGFLYVMKRADDERFETGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJW6</accession>
    <name>A0AAD2FJW6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS5197</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJW6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003368">
        <property type="entry name" value="POMP_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02415">
        <property type="entry name" value="Chlam_PMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042212026" description="Right handed beta helix domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="10">
        <location>
            <begin position="99"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1936449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="438" mass="46306" checksum="8AB73614EEA6447B" modified="2024-05-29" version="1">MSIRSVARVTALSLLWKFTSAQFCTSLKTDTWAGYVDAVSEALDQTGFAVLCPFEISGDGCQGMEEYPEGLRIKEGQSQVLISCDSLLFGYHEESTECVVDCPGRHITVPESSSLTLERMVFSGATESSIKVEEGGTLTVINSIFKDNKANSEEGKGGAIFVLPNSSVHIYYSQFVRNTADYGGAIYGGDFSYVEVVESMFEENKATISGGAFAEDGYSESRFETSSFYKNDASFGGAIYIKELSTAKSLGNTFENNFAIDGGAIFSAGFTSVVDSTFEENAAATGGAVYVEAGSSMTLSRSEFRSNSATKFGPAVSNQFNVQVDAADNTACGNAMESTGVHCEGILMLVPGETSQCVPFTNACDAPSAQPSASPAPSAVLKFGDGDDGAVQFEEDSLMPSDMPSMVPSDMPSLVPSDMPSLVPSDMPSVTPSDMPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK06</accession>
    <name>A0AAD2FK06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="257"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="460" mass="51864" checksum="CF83AD35F811F472" modified="2024-05-29" version="1">MGRRRKQKEDPEKSSSKSAELLPAFLLGGLVVSIAIVFRIYWACKDVPSSPLMECPTIISEKETKKGGLAGLFKPKAATDGPIELELATPNPKDCACRFFFGYFNGNSGREGAPNTCIPSQKQIASKKPSKELMEKYKVAFTSERITVPKDHQQLIVKLAEQTEKQVPDWEERTNKVQWGGSTWPWYMSQPKSTGDSTDLEKLRGGNLFFSYLRIMKWPKTLSAQFPFKLCPKGCDSEVALGHTLEWREKFKPWMYSPAVLKENEKGFVFFHGFSDPKEEGENSSHAIVWIRGGLRNKVADTAQTRAYVNTLERAVAASYARSNGRVGKFNVVLDGTGFAFRLMPSLNSVKAFVTMLQDHFPDKLGIILMTNLGSVGEMLAKMMLKLLSEEVRNKIIVLPHDPQERQAILNTVVSYDYSPTWLGGTDTYEFNAKEYYADPELMLSDKEALEYLETMPYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL24</accession>
    <name>A0AAD2FL24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="3">
        <location>
            <begin position="160"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1939131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="278" mass="31662" checksum="1329AF49B7BA55C1" modified="2024-05-29" version="1">MATNKRTRIQTGHNEPSDRHRKKQCNTLFLENHTETMRRELPHAVEVQTVTVDTVLPVIIERLISLEQAVEQTTKEVKEAKLEIIELINNLKETIPAMMRETMLEVWQSIFSGMATTIGDMRSAAAAGATAPPPPPAMQQQTIPAAAANLLVLTERIRTFTFQSQHNSLKGLWDEWHGLGNYQDLPIAGGVAALEELHGAKWRNTRTNIQQRVSRQGKICLGIKKKSEAESKSIDSVCNEWNRKYAMELNKNMRRFVEFLQEENWIPVPTRRGRRSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL92</accession>
    <name>A0AAD2FL92_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS10523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL92"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003647">
        <property type="entry name" value="Intron_nuc_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00497">
        <property type="entry name" value="IENR1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1946379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="769" mass="88301" checksum="947AA076B5BCF2BC" modified="2024-05-29" version="1">MSSTEQTDNVLEIGTRITCYWPDDDQWYKGTVANELDNDRFWISYDDGDEGEINIKEDKWRRSLHPDKFIKENTLADEQKQAIVEKLELGSRIAVYFPHEKEYYPGTLTKKKDASYLIKYDDGDKEWADLLFRKFKRITKKSDQLEVGSRVAVYNEKRNKNYHGTVVKIKPESAKPHKVKYDKESRGEEWLNLHVHPFLDMVIEWDGKKRKEEFLDADRPIKRRRHNIQVQQEAQENQTEQESALVSEEPCAHCETRADAPYAIACHHILCEQCVDEYRHNDSCKACPLCKTLIRSAPINFSPDHDSFKAVEALSKTTAEVKMEFSSASSASMKVPALNAARIIKACQSKRRDDREHKGYYWRFKGSKDRILRVGEGIKDGIQIEQVDLESGEIIKTFSSGRKAHEATGVGRIVIRRVLERRGKANGGGFFWRYQGETHGPWPDPEPKHLKPLEQLDWETGEMLASFQSLADAKRAMGKPPNSSCIREVCDGDGRGTAHGFFWRWKGSDSIPNHLIGATKVMEIRKKRNGKVLKVFKNSKEAQAFFGHQCCWSSICRYCREESFYLGYYWRYRVLRRPVNSNEAVVGKRLRIKRGGGGDWLEGKIKSFHSDSGEYEIVFDCGKTERRRLENLEYEWKNDQGQKPIEQLDLQTGQILNTFDSIADAKRGIQDANGSHITSVCKGRYHSAHGYFWRYKGSTEIPRKKKGRRKIDQLCLKTGRVIASFDTITAAGKAVGITTPGISYCCNGRNSSKSAGGFGWRFSTKDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLQ1</accession>
    <name>A0AAD2FLQ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1142"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="982"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="982"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1036"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1942310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1285" mass="141580" checksum="CE1F33153FDF65FF" modified="2024-05-29" version="1">MMQAALEAAMEEAAARESGVAGGQQYHEDEEQSQQSQQSEESSQHIEHSSSSQQHHDLDAEQLVFLRALQDAEEGEQAELLQRMIELGQDDPSVQALLQLLAQEERENARPEEHYLTIAQNGMILEATKTATGYPPDALLMTSAYDAVYEDDLPGLLAVKTHFWDNGHPDVEVYLRRRTIDGDWIWLVTKAVSYVDQPIPGIILLERAVDDVEHANRISRIIRISAILVQAVEAAQVASLNPGLTDELQGSDNGSVDSSTQIPWVAEDAAAYQAMLQGGAAAAGGHPSVEDTLAQIMKAAATGGAMSKNKAAATAKLEQEIMERYGTKKKESFDPFSVLEEVREGVRLDLGMISLSESEIKMITMVLKGEIPAEDLATLVYQALSVGVGIDQALREYMVLRSQIDEPGDSLANMPPIAVLNLSYTYMGNTAIEILSDLVQMEGSLLRTIDISFCALDERGTIIFANALKQRRRRGIAPLRGLIVSGNHITLKGARALGRALCPEEPSPSDDSSFGDEAKQEQTEAMVDAAKKYLSKNHGLQVLHLGSALKDADSVAEFLGGLGPNCPVKEMSLTSNGIGASGITQLVDFLEGKGMPKGTKVMKHLDRLDLSNNRLGNDGLTQLCRAISKRNGMQLVELRLSNNAIAHSGIETMMSKLLQHNLVSLSLDKNAIGDQGCQIVAASLNGMRSLSRLNLGFNQIGSRGVNSLMRSLVACDSIQYISLSGNIMKISGAVALAFLLAQHPRLEELDVDNCCLSQAAQCHIVSGIISNRWVPMKRMNGFEAGPPMVALGALQISAQSLSNEECFRIRKDEQMKTILEWMESNRNAKLAGARGAGLGDVNSDSYQHFLSPEFVQSQNEFQGIPSQNAYLRLLGWLSRIPFDEDELISLRKYFYDSDGASEDRGSEGYINLRLRGDLLAALESDVADELRDETPMLVKYQGSVGIDLDIINGGNNPDASPWDQMLGKSFDKPQRIQADPALEKIPDEEPSEHMMEDDNSWSGHMSDEEEVNRKRRMQQDFSDDSFENNGDYRGPSSRSSMSDMSRQSSSTESDGESYASDDDRRRNRGIKARITMFPQFEYKLEELKATATEMIESEEDQEQQEIILTQYAEASLTILRQLRYHCMNSGLDGWRQGSVKRKVLIVDDSNVTRKLVSRAFEKANFIVDTAANGLEGVKKLKTSIYDIAFMDIDMPVMNGFEATKKLREWEDAVRPGTRQPICALTAAYVDGIIERSELMKCKEAGLDVMESKPCNIPRLFKVVDDVSPMFSDLSISVIQKERGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLQ5</accession>
    <name>A0AAD2FLQ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="294" mass="33923" checksum="6BC64E66E973FB63" modified="2024-05-29" version="1">MEEVFLQEMVRDREIQIGMIRKKLEDQEKKLELTKKSLEETKKIYTENHLSHQMELDELMQKQSKLLSQYKDANEELDLKKQQQGPQLQVYNEVMSSLETAEGDEAAQDSSYVTRMQAQLCKAMHSMGMVETQLALSTTQVEGLQKQLRESKTTLIEDKTQVELKLMNDLVLADNARKEVSEKVTKQTEEFTAQKDALLEKFEEQQEQQDEEKEGEEEEEEEEDDEEEKAELTEILVEGREEIARLEAENAKEKAKLEELKQKVIALKGEELVDALCAQIAEDCGVGTEEAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMY7</accession>
    <name>A0AAD2FMY7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="143" mass="16064" checksum="4E446A546CE1F061" modified="2024-05-29" version="1">MCTATGISRSKMVKRPIHNTLKVCATNEKSKPTTGAASATNFAERCTTNLETRSSSRFDAVTFVGRNTMAPTLPCKERHYTARSMDRHYMVQSLDRLLREETASPEPLNKPRRWCSLCTGSPFDQMFAESAPSEPLTMPRRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN78</accession>
    <name>A0AAD2FN78_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10838</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24532</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002528">
        <property type="protein sequence ID" value="CAJ1970516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="188" mass="21515" checksum="46544CF304F51215" modified="2024-05-29" version="1">MPPHSKELLTQPVYEHDLVSWGSDICSKMVLETMSFGSSDHQYQEKRKVAFSDHVEIFEIPHVNAISAQSKRDCYFSREEIARIHAHAWEIVDHMNNGMEIQDDEDFSKRGIVDLKDTTMQRRQRQRQKAYKVVFGMQAFANTRQPMHCGDPRDFLAELYSKAASDAKKEAYMSAIRDAVAAGMAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQM4</accession>
    <name>A0AAD2FQM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009858">
        <property type="entry name" value="DUF1415"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07209">
        <property type="entry name" value="DUF1415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042056801" evidence="1">
        <location>
            <begin position="21"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="47687" checksum="FBBCB946220768A7" modified="2024-05-29" version="1">MITFLAAVLIFSLQTNPVLSLWVQNCKNGARFNRIRMTKDDFVSKTSECPFSKAFPRYKIDLSRLKEHSKHSWFSSPFQVISNSVQRSKLEGMLTQGEEIHWDSEVEGVSAMSLLWHRSSQMISNARVLSSEIVALPEANLQLVQNWVEIVQWMSDGDDSLLRASLLTSESSGVSVPAVRIELLGTLEDDLEDNLGPTTNTDSADVLNARTRAWVKRILVEQGICPFTKSATKSGHGLSDVGVPVGTIAYHASFAEDAFHLFADTWKAIDEMIKAGPSGKTGVSSILLAAPAFDDDFDFWAGPIFAMLEASVVAAQAQEQIGVVCFHPQYATPDGKSWPGFGHMHSLPRLQKWYLEHSDSKDLTTDDIAAGGAWQRRTPHATINVLRADQLEAAESKRMSGSMYTENIEKLIRSIGSSKLADDLEQERQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQN6</accession>
    <name>A0AAD2FQN6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042173527" evidence="1">
        <location>
            <begin position="18"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="361" mass="40043" checksum="EE44A4B4CE8413F9" modified="2024-05-29" version="1">MFRPVIFCGLIVRYVSSLVPQPIDQHRRSLFESPIQALQLSCVLGLPSSVSALDPNSSGPSSSDDLQVLFWSGPTWNESRYRASTLSGYDQNKNAPVPFDSAKITYPGWMKGYWSVKYKFAGADFPQGKKILSLRTAGAGLGTCLVLPNVGYNPPAAHALRFLSNENSDENDGFVHGDLAYNLPRRLESFWPESKVLSVQTNGSSDSRMTPKCFVTGDGCAVQDNPKLHWVASRAVVDFEAPTRKSGRQVQSSDVTLLNFTSPSFAEGNSNSRFVTVQTYSQFNPSQELQTFYQDHLLLERLKGSDGQDVISGRIRVAAFLPHYIQQLDGADSSYQDTKAVAVYDYKIFMKRIDENEAMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQU5</accession>
    <name>A0AAD2FQU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="153"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="304" mass="35091" checksum="D33B5DA7D002F1E1" modified="2024-05-29" version="1">MTTWAWMQQGAKPSVKNNGSNNESNEDKDIMDDNRPLISDLLTEHRERIDEFQTQLSKDDLYDKDKHDDLWMLRFLLSHKKDLDKALSAAKETLQFRKKYNLDDKDIRSVPPQDIKEPDGVTSRGFQCFLNNGVPRDAVRLVAPANEKSHAVVVYFSIKDIDTHKLAEVKQEDWVAGMVYANEWQFQWNDYTSRTTGRLTKSIHIIDVSDINLSMRDSTTQEKYAKAGKELQNCYPQGVESYFVCNAPFWIQGPWKLLKPLLPVRVVSKLDFLNPKENEPDRDQILRFLPSSQLPTQFGGVSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR06</accession>
    <name>A0AAD2FR06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS12008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1949267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="361" mass="39766" checksum="D2F3B267CB624597" modified="2024-05-29" version="1">MAITSKATLPTKSSNKKGPRKTSSLPTETVEYLKAWMMSPEHIAHPYPTEPEKAQIMADTGIELKQLTNWFVNNRKRYWKPRVEARLQQQARAAAAAAQAHAAAVAVANASAAHTNPVSPEQGYKPSLPLPHAGNGFVTFDLGNPSVPTNSNNNTTTTTKLPSRRYTHLVDTDMARVMADHTANADRDERIVSENSSSASVTASDEGTISDSATYQEEEEEEEEEIVQHNSFKTCSPSELDQQQKQKQVQHVQHEQMEYEEDYSSEQTTGESSSSVSIASSARATISLSSFEESAPTTTATKKRVFVAAPTVVTETTEPRKKFRRVSIGLWRETCQKAANVYDDDALPSLEEATQLFGFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRA1</accession>
    <name>A0AAD2FRA1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRA1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="306" mass="31107" checksum="BD99015B85CBFF84" modified="2024-05-29" version="1">MNASTMTRACEILLQPEVEGEDDDNKDIKASADELLAMYHKCRADFATIQKHQPRLPNLALNNGTLKLGGGGGAAGAGSNNPNALSAGHSLQMRKKSLLSTAGAGGNSGTISAKHGIMRSKKSLVPHGRRNLNDAISSDSPLAKKARLNSNNNTSHTGGKSTATTTSEAPPKSALKFLNKLNRGDNGGSGVGGGGDGKNASSSSSSTSSSSQKPQKLPKPQKPTRSTSTASSSSSGSSSSSTKSQPPSRAATAAASKDDTSSTPPTRSRPARAAAVAATKEIMSSSSTSSSKRSQPTRSSRRGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSK2</accession>
    <name>A0AAD2FSK2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSK2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF5">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042034109" description="FAD-binding domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50563" checksum="8C1F025F38686D3B" modified="2024-05-29" version="1">MMMLKKGCCSLLLLLGLVRGLASTSPSTGKTLVSGKKVVVVGGGPVGLYFAALMSQKDPTVQIEILEKRTGKSVNAFGLGVGHRMQNRLNDIPGLCEKAIEISATVESLNIPLVDRGDLTRQMSSFVLDKFGSNCQLALGEECDSVDFENKSIITNTGRTIQYDLLLAADGVNSKIRQKLVEKEPETFQEQHYLENSHWKALSLPKQPDIGKGSFKPLRHPSIASGRVLPKAPEGHVLLLFWRDEHGIDNPMGIETTEDLKQMITDAMRDKNTRGVNPLRKLLGLEQGDSHKSDRVVVFEEAALEAFISQRAGRSHHLKINQYHYQDSVALIGDSAHAMNSLLGQGCATGLESTHTLVQCLLGEEETTMEKALSRYTELATKEAHAMTELSLINYAIKGPLTILKALPLILLNMLRGRGLLKRLVDISVPFSQIAKENKSLLKMCRRKFEKQRRAFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTK2</accession>
    <name>A0AAD2FTK2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTK2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="121"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="203"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="277"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="356"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="475" mass="54358" checksum="DE9549B453570B7B" modified="2024-05-29" version="1">MRESKIQNAADAGTGFDAASSNEPTMNTPAIQTNMTDRSPMTSAISKGRPTDSSSSDRTPPRAEAVALAAMQEAATILMEADQKKRSAEALPQSSSTTNTTDNHGNNNSSKRARTSSTRIPWATRLEQLKEYKREHGNLLIPIRYKANPSLGKFVHNTREQYKIFTKVEPEGYKKRCSLTAERIQQLKALGFVFSTERSKLESEDWAGRLEQLKTYKDKNGDTLVPHGYKPDPSFGEWVHRQRTAYNTHMKNPKPNPLLEGRIAMLKEVGFNFTVHNDKWMEQWGQLKEYRKKHGDCLVPTHFTENPKLGRWVHTQRHQNRMRLKGKKSCMTIDRFELLNQLDFAWVVRATLERPRATWQQRFEELVQFHSSNGHFKVDAMSMPQLNKYILDQRYRLRLLKKNKGKDVTKRMGPDRVKALSEIGFTFETVVLDKEGAICDSAREERMDEKVAVGAQSSWGSDRALLREAAPEKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTT4</accession>
    <name>A0AAD2FTT4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribosylglycohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTT4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF34">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1952775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="49162" checksum="59C941EB3FB7FD0B" modified="2024-05-29" version="1">MASSSTANITIDKKRVAASLYGMLVGDAVAMPAHWFYSPTKLRADYGEVAEMMAPKSTHAESMVQGMSYSGTIDIMHDKARFYTGNSLATEAQKLTKEEIEARRDEHGNYIGVTEDSRVHYHATLQKGQNTVNSCIARLAMRYLAETNAPAGRDGYDPDEFLQRFVEYMKTKPDPKNDPDQLLNHNDVYMDIYVRHFFEMASQGKPLRDCPKNQRDQWSIGSLDGVVMSIPTMAAYANEPEALLIGRAVEHHMLTHRSITVTATVSVLAPLLLELWKGAPLKESLDRAMDKLRPPKITGRELRDSYVGKGGPGRIPKDKKWLQHMELLPPGTTTKDLVHELIATVEDDEDVAGCGDRENSRLSTMCYCEQAFTVVLYLAYKYGTDDPRKALLQNVMIGGHSTARGAVLGAILGAAYGVEGLPFVDDLCAKKAIDKEVSDLIATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUS1</accession>
    <name>A0AAD2FUS1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUS1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042862">
        <property type="entry name" value="RNF32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14991">
        <property type="entry name" value="RING FINGER PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14991:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="539"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1953910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="748" mass="84684" checksum="6B1C61CD2CCD362B" modified="2024-05-29" version="1">MPNIEDSSSSMEDEHLIVEASPHHEQGGNNSAPLVLLRRQQQEQRWRYHLSRSGSATRFHRIFIRPLLVFLIGFWYLQRRSIVGRKDQRHQQRPELEKESSYWRKPSLSPSSSSSSSASNLDFHIGNEHSFDSTSSSESISSSHTVSNSSPDLLVSSSSHMNKQAFHEPYFPLYASVLQASSEDSPDADDPESFGWEPSLYPNPRENPQQCGISYLLQDEHFIHPNDTDNTLQLCDPDWVLGGIYLEEIGAAMNNFVETYSSLPLPDTDNMGDTPPPIDRAKNESPVNESLASPNLEDTSIGEASVPFVELGIATVRKMEISAVLEQDVYYSSEDEDDMVSDAAQVFARYLHDRWWQGNPNGEYGILIFLSIEDQVCFISTGNAIAKVLPWWRLEHTVSIMKPDLRHRDFGHALLTAIHDLSDMLAEGPPTLADRFHDFMTRFGIVIAFAVFTFFFGALGELRDRRKRWAHTESRSKMSQVEREKARLLQREFKTRSCPICLENFDGGTDSEGNLYQLSIDDEKHREEDVDSEDRGSCCRSCCTPKSIKEARSPDKEQAPINSGLRRVDSYGIPLLGPDHRNVKMLRCGHIFCESCWKQWVHSGQGNPSVCPVCRQDVGKSSKHRRRRRQQQLQHQQQEEEEARSQEQQLEEAANAASPTLPNTDTTPLMNNASTRTSGGTYDSLSSYRTLSRLDGADEETGHGDSITVNTRTTNDGQEDENGEGDQDETQSLLRNGSRRARRNWFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV61</accession>
    <name>A0AAD2FV61_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="232" mass="26084" checksum="96C33E95D9D55018" modified="2024-05-29" version="1">MPNDGFGDVGNDLADSDDDSLLDVIGMVGGKSNPVAENNMESPSASTATRVTTPSSTSTSVDQRTPRPSPTLATPTPPGKRAPPPVILKQKSPNASKKKQTPGDPVIISARKRIKEETMESFLRTSQSQLDEEGSKKQKRHEENVGLKKEEISQREKHFRMRFEEEQKVFKRQAIAEEASFRKACLAKLHGLLAENKSDRYIHFMHPHLVDILKQFRELEEHCKLRSCLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVF0</accession>
    <name>A0AAD2FVF0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVF0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="318" mass="34344" checksum="ABBAC1EBFB5785E4" modified="2024-05-29" version="1">MVENTTAFENSGSLSLGESLMADEDQNTGDYEVVSHNGSEIRSAPETSTRNAYFGSGILILDGVEGEGVEETGSVLSIPGTDSLPTDVGTVNGQDIAYRGWTIPKYGIFLLSTVLLGLGYTTYTMYTWRSASFLKDEQIAQHLATIQRLEQEVQEKETALGYFDESDYITVFDNCWVKAKARWCDKGGPGSFPQIFGNAIGEASKLVTDTFASLTDTMKEVPEAASSELKSATDAVNKVTDAFSLFVGAAGDAMFAELQEFSDNPMDYMAEAVKGTHNEPEITGKGVDEVMNIMTGKTFYMTDDEAAAAKEAAVLNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW27</accession>
    <name>A0AAD2FW27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042104897" description="EF-hand domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="267" mass="29763" checksum="16F5B367723B3451" modified="2024-05-29" version="1">MNPSKRGILWILAASVYLAAPVDAFSASSQKRKLTSSSPPPVVQQSSRRQYIAQTLGGIISGAGILVSNPTPSVASSTARVQKWPGVEYLEPVYELKLSFEAIAKASEDESQYASLQQRLEKFFKGTIYSERNVYAGVALSYTTQIQYDPNEIQEYARLDQQERFDLMENALDNLRNLYISLPSTPDATVNKQDISDFANGATACMRRWFSLIATAEVDRAKELYEAARSADANKDGKVDVEELQAVPEEYRTLWKKRLEFTGIGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWB6</accession>
    <name>A0AAD2FWB6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="315" mass="37094" checksum="53F27A57ADE5D6E2" modified="2024-05-29" version="1">MNTDQSLKIVGLLTFLVVLTTTFHNMHVASDSIKASETLLQQFLDSSSSRFGQGTSYYQTLPSQSQAICFVTASYALNETVMDPLPDMTSYKWPFKFFLFTNLKETQWETPGWEKVVTDFTYRRRITHSRYGKFLSWKYPRITKLCRAIFYIDSTIEPTKNISLWEEAASRMEANDGPGFMQYPHPKNRSGLPAEFRAIRRSRKDTYLNVNKSWTWMENDPSWTPKMRIFLNTCLGYNPKSKTFQKVSQSFWDRYSLELDSWRDQPLWSFNLNRHKVIPLNFPDTFHEIFKQANMSVYGHNGHTYRKDSEVNVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWP6</accession>
    <name>A0AAD2FWP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042269254" evidence="2">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="246" mass="27570" checksum="9DB76908DD4ACB7E" modified="2024-05-29" version="1">MMRTTSSLLGLLSILILSFSTTTTATLSHSDSSSGLVSSPKATIAVSQSLVVPSTVLEIPRGGNKRVVPRRKRSSVKSFLGWRERVQEIGDSLTEFTERKTFFSTQLMPKSEADAEWAAFLKGWLLVALPIPLPLMFVALIAYSTLMSFSLWEDPIKRKFIIGLYHGVLVFAVVLREMEEKIEEITHPRQVMILLNVATNLFLGKTGRFKATKFLMDSSTFSTLFYILYQYFDTSSTGTSVGGWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWR0</accession>
    <name>A0AAD2FWR0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="613" mass="69266" checksum="4829E4035374846F" modified="2024-05-29" version="1">MKSFEIIAPYFAWVNKENFPYIVQVYGQLDIPFWDDYSESFHQSSTDVIQAFQSSFKFLDLTFRPFLQLLFIIFSGLFEVLLKQGLISLQKGSTQAKAGTIWFYNFQRSLTKEQVLGEIGIVGFFFGIYFLRKWLKRQTYWARATKWFSNQKKKVKKSYTNAVKRLSKVSLVLAMTVPHLFFLGIVVASKILMPRALEWVVHETYTTTTMSLCYPFFSTLLLIHGRRQEDKSPDENTTLLAKDGEISAGKATKSKTVAELKVSSTNKSRMNKKTSDGSGRTDSASFWLQYWITYSIIQAFGQFCHMVPVFGRFVAKHPFFQSLSAEFKLFFFVWIFTMEALMGGNTEEAFLAQATPLKLTTRYLNPVILDLDTVVSQAISAAKWKKLVFSKAQRVLDVFVMVRLLSEERKDWLLHILEESRVLLIPSITLMMPSFATQFGVAYVQYIVPSAKSAHARGANSQLMFLQYWVLHCIFLGLLTWLAPLLWWIPFSTHVMFIAWCNLSFPKTIDKYYGVLEMELITFGILSGTSGIAVNDTHTAQLINAISKRLPSAQDGDSIKSATATDGKQASSVSVPNLRSEKSVTSLSSAREKDANSTSPGAGDASVASSPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXD7</accession>
    <name>A0AAD2FXD7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001889">
        <property type="protein sequence ID" value="CAJ1955465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="204" mass="22916" checksum="D990393987E86B82" modified="2024-05-29" version="1">MSYDNGSYYNSSPDKVRKRNLKDWMRFGSKGDLNTVKSGIHSAFREHNGGCYTRLPKKKRVGLGSLTTPTTPLQHGVVMKIGSLAQCPLKVDWKKLARQLMKHINFLYPIRVDVGWPSRPGTDRRWSGSDPKSMGVFVLKEHTVLIDGVLSKKIHITVPKCDCLWGIPFAYIPQAQALESIEADNVASQLDIAAHFSIIHKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZB1</accession>
    <name>A0AAD2FZB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09279">
        <property type="entry name" value="RNase_HI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48475">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48475:SF1">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="241"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43139" checksum="C7B057830F7F3793" modified="2024-05-29" version="1">MRKSDLQMECSFRGLPTKGDRSILISRLMKTLDDDNDVKPKGHAHLQNLDPSDTSVLRVKGHTTPNSEGVGVGLVLYHSETNEELWSGRIYCPGDRAGFEAEYSAIIMGLDFCKSCGIQNLVLQSTNNAIVFQINGIYKVSKQSLKPLLEMEKEHEEEFDSFSVAAIPNSENTVASELATKALSTRRSADTPKFWKFNDPILTLSSDVVDADVMDVDTIAGEEIDLDNDYTGIPQPAEIDPSRVYLLRFDGGSRGNPGVAGAGMVIYDDQGNEIWNGWKFHSESATNNVAEYSGLLWGLKCACSSLGITQLIAEGDSQLIVKQLNGEYRVKDAMLKKYHKACVDVAGNFEYFEIRHIPRAENSRADWLANHAMDLQQSHGCGDEEEDLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G003</accession>
    <name>A0AAD2G003_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS17258</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G003"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="12">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="10">
        <location>
            <begin position="416"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1958602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1073" mass="116108" checksum="865ACFB291BD49B1" modified="2024-05-29" version="1">MALSTDATQLSALLAVLTQPDTEAIRQAEVALKPLLKDPRCVPALVEILKSKDTQTPPVRHIAGILLRKRLPGHYGKFDLPTKTALKTEILAILSSEPERTVRNGVVGVAASLAKLECTAGGTSWPELFQFIAAAAAADAQQAEARELAFWLLQEMTDTIGMHLKDQFQPICGLFSKALVPNEDAKVQKAATKALGQLLSFLADEPEVDVFAGLIPPILQVAAQQRSDEELLSTVLDVLYDLAYSPSPAVTQHLIPMVQFGLECIKLQDLEMGVRDSAALVIATLAEAKPKTFGKEEALVAQVLEVLFGLIENSPDSAAGALFESNPAWREDLENDEDGDFDPDELDSPTETSMAQGTLDMLACELPKKYIFSPAVTRCVQRLSSPQPNHRKAGIAGLGVIAEGCSEPLREHLDELMPHVLQASRDGDPQVRECACFCLGQISEHCQPEVLAYSEQILPIVFGLLDDQSVAVQATSCYVLEMFCERLEPDAVRPLLDSLVKKLAAMLESTNKRSVQEMAVAALAATAVAAEEEFTPYVGGVATLMTKCMAVTEERLFSLRGRALECMGHMAIAVGRETFRPYFQATMECACEGLTRDSTDLHEFAYAVFANLAKVMKEEFAPALPELVPHLVQVIGTDEGQLEPAEDAEKGGQFNAFDDSDGEDEEGGNYVLHVRTALLEVKKGAITAVGEMAAHTGGQFCPHLESVMQVLQKAATNWHPLIKSEVADALPNLVVPSVAAHHNGELQWTKGDVSGASPMSEHTSAVVAAVLLELMALMKDDDKTTVAKACEGVQSVIELCGPHSFMPIAQQCMQNTHELLTKTAPCQAADELYGEAPEDDDDHDIVTQAACDLVGGFCRVMGAQFAQYLPQFLPAVCDYAKSSRPPRDRSMAIGWLSEVAQELQGSIFEHWQSVFLPAVLGGLGDPSEDVKRNAAFCAGVCCEHLRERVADSYPQILQALEQLFQIDPNATEAAAACVDNTAACVARMIMASPTHLPMPQVLPAVLKLLPLKTDMTENETVYTCLLGLLQMNQPDAIAQKAEFRRIFSEATAAGSKVEPEIQEKLKHALPGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2B1</accession>
    <name>A0AAD2G2B1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">GTPase Der</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS18607</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002050">
        <property type="protein sequence ID" value="CAJ1960191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2B1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTPase_Der"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43834">
        <property type="entry name" value="GTPASE DER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43834:SF6">
        <property type="entry name" value="GTPASE DER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="G" evidence="9">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="9">
        <location>
            <begin position="243"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="GTPase Der C-terminal KH-domain-like" evidence="10">
        <location>
            <begin position="426"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="517"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1960191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="548" mass="60297" checksum="89818F4DADA7ED21" modified="2024-05-29" version="1">MLADPDFVVAILGPPNAGKSTLFNRLQCKERNKSYKLGSSSKRVNGRISSKANSRGNAIVSPIANTTRDRRQCWGRIGSTEFQLIDTAGVDGDRIHLLGKSQSKEPILEKSMMMQTLAAAEQSDLNLLVFDGKVGVSHDLVATARWLRKLGKDSQVVIVANKLEGDSWAYEGSDVMQTLDEVTRLGFGEAITISALQGDGMVDLAVLIEQMKTNKKVRDVKSGVLSIPDGGAPASVPDKPIQLAILGRQNVGKSTLVNKLVKSERVLFGPTPGLTRDAIAVDYDWDGKKVQLVDTAGIRKFTRRAEDSIEDMAVADALRAMKVAEVAVLVVDAKELFLHRQELAICNAILNEGRALVIVANKVDLLEMSSDYGPKDFAKQVRLQLETAIPMLRNTPVLPMSCHTGEGVSALFPAVLDAKRRWSKPISTGLLNRWLKEVSNGSPLPVVGGVKSKLRYICMKKARPPTAIIFTNVDHLPDSYLRYLTRHLQESFELYGMAIRIIVKKSATNNPYVKKKGNRSGFGLGGRDARNRRRIAEYQKKSKKRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4R8</accession>
    <name>A0AAD2G4R8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS19917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4R8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053038">
        <property type="entry name" value="RLP_Defense"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48064">
        <property type="entry name" value="OS01G0750400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48064:SF6">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1962917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="80141" checksum="5806C4D806715136" modified="2024-05-29" version="1">MTDNNIDQETPSEEFTMDIERPSPPTTPAAITHHRVDSSTDLPVPAPPGASPETIIDVPPPIPEDKPLEIASSPVRPSTMPPPMTPDPSKKPPPPTPDTVASTEDEESKEDGQSSKFYEEELGGGGAIVDTSNVVVQENKKKRCAFFTTTCGMIASLITLLVIIALITAFVFLFKQGNDDTVPRSQFNDVSTLRPTVSGLLETMMPAVTTSGPPTQAPTQAPTRFTDPTLSPTGLVVTPIPPFIGQTPTPTGVAVTVRPTNPPTQKPTPGPTVVAEPGLTNRPTQRPIPGPTPNPTSRPTPGPTPNPTSRPTPGPTPRPTPIATPATTTNRPTQRPTPGPTPNPTPAVTPSTTTNRPTQRLTPVPTPRPTPLVTNPAPTPSSSNRFQDTIVDFLFQDSNGINAATADSASVQKAVEWLGNEANAAQSIPFPLDRKYLQRFGILILYFSVNPNVQTTNSDNALLPNRDMRNQDSCSWTGMRCNENGMLTRIRLAKRQFDGRLPVVWGFFPKLRTIDLSKNKLKGSIPADLFENALELEELYLYKNQLSGSISPKIGNLWLLRRFHLSHNSLTGSIPKEIASTADKARLLRYFNVHRNQMTGTIPSNMRLRQLFSFDLGNNAFSGTLPPDFGTESVRLRHLYLDYNGFSGTFPSEVLNAGDGRLITLFINNNEFTGTFPGDHKSTTAIAEMTIQKNNFASMTRNATCELDVFSGGELVEFKSNCLVCRCGVGMMCRHCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5U4</accession>
    <name>A0AAD2G5U4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5U4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25594" checksum="3D85789285E6E89B" modified="2024-05-29" version="1">MSSYHYFGNKGERIPDDVEELVVHPLIHEIPAHACSNFEQLSRVHFNGTSLRAIEECAFDGCVSLLEIEIPPSVAVIGDSAFMECEALTRVRFHEDGLLTTIGNWAFQKCSSLAEVSILCSVETIQKGTFSYCELLARVFFQEGLKTIDRDVFASCVQLETVDIPRSLELLGSGAFYRCTSLQEVNFDEENLRVIGKHAFMQCFKSCKQSTFLPLLSVLNRTHSATAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G684</accession>
    <name>A0AAD2G684_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G684"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="474"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="750" mass="82257" checksum="6D43E3C4F5ECBFCB" modified="2024-05-29" version="1">MPTETMAFTEPVKDEIESPEQPTTTTTTTTTTKTTTAEEVVKEDSKTLEPSPSVPKDSKTPVLETPTVDEKQPEEEKKEEATESVEPLDKEAKTDNKTMSEGVEVILDAGNGSTILDQDQNVFRAPNPVRPRAMRAHPHDVKGSASYGYGPADYHQSPYPYAPSTSFDEGGYPPMTASHYSPHVQYPHPAMHVGDVNVISPSHKEHAPSSHRPPMTPRRGGGGHHSYQYPPASPVSRPGGHHSPPRMRGYHMRRPEGPYSAAVRSRSHPPSHGPPTHIRHPEEEAWGYSPEQRPRPPIVAETSFDSEHYPSHASHASNPATPNAPHYGPPMHHDGGSAYHHHHQQGFQGGSFGSFESPAPGYYAEQQRGHYGRPSPHYPPPESPYTPYSQHGYPGYSPGGYRDYYSPHSDYHRRYAHSYEDEYGHGGKKNDSGMILPKAAQEIDFEVTDPPMEPIIPASKTPLCESPADVNSYDVLCGRGGGTNSQIGNRRFRKLVQEFQPTYLLARRKEKPLLARTIVLIIRKRGGRFLKKDEETGELYEVGDVKAEAKTSQALREGLDVRATKSAASSIMDKKKKKKSSSSLTEEEKEVDAMSPASHTDSPVGVTEMKSGGRPAAEAPPSLPTLAQDQPAPTPPSPPSPNSVHFRKRRRMRSGDASVGAGAGCGMGFQDKLFPDFCPPRADLGRVASPTMEMAMDMSHTRHEMKFEDDIYAHGPPPPQQQRAGCGGIAFDIVTGAAASSFCMGPRKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6N2</accession>
    <name>A0AAD2G6N2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6N2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039633">
        <property type="entry name" value="PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006843">
        <property type="entry name" value="PAP/fibrillin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31906">
        <property type="entry name" value="PLASTID-LIPID-ASSOCIATED PROTEIN 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04755">
        <property type="entry name" value="PAP_fibrillin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041995010" description="Plastid lipid-associated protein/fibrillin conserved domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="4">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Plastid lipid-associated protein/fibrillin conserved" evidence="4">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1964281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="191" mass="21439" checksum="8E702FA90929F3CF" modified="2024-05-29" version="1">MMKSCIFLFLLKLYFSSAFIFGASREQLKKEIVDLSRSVDRGLTSTPEQDAQILSLFEKLEKMNPTRKTLKSDLVNGVWSLEYTTSALILGKGGVGKRVGPVLQTIDTKSLSAENSEVVDYFGIKVPSKVSAELSPQNDRLTNVQFKRFSFGPFGFDAPEQFKGYLDVTYLDQDLRLTRGDKGNIFVLTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G725</accession>
    <name>A0AAD2G725_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G725"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="165"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="345"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="50491" checksum="1459A7180BA025C1" modified="2024-05-29" version="1">MEEEVVNYNFVRATESKAGMLESDEIGPGDKIDSLIANALNQLSLDERETVYYEMHGVDEVINETPELVNTSLNLLEIELERIKATHRKANAYKMAEEMSPDFVHDQTLRMKFLRSEKFDAERSAERMIRFFDCKLHFFGQEKLCNNITLQDLDKDDLKALKAGFMQILPVRDRAGRAVFLAVPSKQTFNNPINKYRGLFYLVMAMSEDVETQKRGVSIVVYNVEKFERDKYDNDAVAHTTWIQNSVPMKTCAVHYCISDSAFRSVINIAMHFFSEDTRARVKVHFGTHLECTYSLMTFGCPVHCLPVGLDGKLKRKAHLEFIRMRQQQEARVGLPRIVLPSHDDVLFGRGKPYRQHIANLRLHEMMEEEMKQTESSSLKSKRMLTIEKLTEAIRHEGGRFLQQDEVGCWVELDEKVVHEKVNRSFRTRLRNNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7B0</accession>
    <name>A0AAD2G7B0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protochlorophyllide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7B0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42500" checksum="8EC5F1E6D4E8B81F" modified="2024-05-29" version="1">MPEGGNWKDLFKAAEEGDLAKTRYHLAGGVDPNWQHPEYFTAPIHEAIKNGNLEIVKVLVEEGGANPGLMEELTDDTTIEIARASLQFEILDYLNSKVPAEARFDSRVVLVTEGLMGTGKPLALELLLKGHQVFFVASSEEEATKASEELRLESGNSKLGYIIGKLSTIADVYKLAENVQQQIPKLNTLIHNACIWPFSRQTNDDDLESSFMVNYMARYILTKTLKKMLEGNKAPRIIYVNPETTWREPDLIDTPIGVNFSWYKSMSETVACSTISFLNCLQDMKGSGVTVMLAQVGKPHNSIEKESSGCYWPLVEIAQAVFPDARNVTDTIAWMVEGGQGKNFHGKIYNGDKEEVTNYTVMSIPKEWEQWTTDFLSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7X3</accession>
    <name>A0AAD2G7X3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS21374</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7X3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000008">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF58">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="36"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1965782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="521" mass="56493" checksum="D9F4D7CE0FE3B5E0" modified="2024-05-29" version="1">MADSFTCDSLAGSCEKLDNLFSVNAYSEQWKDDATWILTSSFVILTMQSGFGLLEIGASSAGNEVNTMLKNVADILFGALAFYCVGYGIAYGRPSNSFMGLGDFFPDGDVDAVSSGILYSRYLFQLSFAATSATIVSGCIAMRMRFEVYCIFAFYAVVIYSFVAHWVWAPGGWLFEMGFHDFAGGAAVHLHGAVNGLIAILFVGPRRGRFDGSRPASDFEESSPTSMLFGLFMLWWGWIGFNCGSTFGITNDKWIVAARAGVITLNTASAGGLTAMIYSRYRSGGKHIHPGDVVNGILGALVTSSPTCATTHTWDPLIFGALGSLFTNFINDTVMKKWLQLDDPVGAVGVHLGGGMWGCIAVGLFADKNLTGAGIDVSGLFRGGGFELMGRQLIGIVAISGWSMLTMPPFFYLVGVLFSRDWKDPRKGLRHEFVQMDRHIHGCTEDPTDLITVEIQKALELRDSLMVSHRRTEQGMLTGIRISNVRQIHTHNLNIPSGNDDDLDATASPDSASNTSQEETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAS6</accession>
    <name>A0AAD2GAS6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAS6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042277104" evidence="1">
        <location>
            <begin position="23"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="538" mass="61358" checksum="8CEA1BC6F8C1FFB4" modified="2024-05-29" version="1">MNWKLRSFLLLTAAALLYQSLKLPADLKAFLDPEDLIHLNSNNNTPRNQKNDLDFHQNGTSVRNGETHAWLDHIYYFNSFVNPEAERFMESWLQPIKHAHIERVEEISGSTSNYQSCAGEELSCKTSTETKRIGYTYYRFGSAYKKGGVSLVLHHDTMALDLEKLRHVVETELKKRNIRWSVIRLDCGQNERGQSIEASTIKGTGWAVYPSPDTQDSESCGTSKAILWRDGKLKKMTKLLTMLHGDDPEKINIDCLLESREFGSYCLDSPGIIQHSNQLSPQPTPIFGTWDYGRIQQTSNQNMENVHKKMPLAAEHEALAIRVDRILYVNLAKNKLRRQFMESWLSRHSIPYQRVNAMSSSVQADSCAFDKTKEVCRGIVGYDRTLVHTLESMADLQTGNTMILEDDMLPSDSRLDRLVQAIKIVPPDWELVRFDCWGMEDFNFDWPNPFVAATNSYSIKGCDKVDTKNCHKTFCGGSHSMVFSARGIGKLKRMWSTKPYQNADCIIARTPSLRSYCVNLGFWETIHIKSELSDISGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB12</accession>
    <name>A0AAD2GB12_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EIF3d</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS22616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB12"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1967105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="63102" checksum="6D41ACFE4095DCAB" modified="2024-05-29" version="1">MFQPNPNPERNSPMATFSIPYVAPNADSWGPPDTTDEANPNAPSTSKFADLPYSPFGRSDRLGRAADFISGNRPGQYGRNGRYVKGRPFKEEGEEGEESFQLVDTSKTTTTKRFVTPAARRRQHTARLRQVNARRQQNSVGSSVSKETLTRKGPGGRGGGRGGGRGGRGGRGHRYNNNRVDRSPSVAVQPDWVKVEELDLAKLTKHLSTSTTVPTAQDVLWCGFLDPYNDSYDKVTARQPQPLKRMEHKEFYPVTTTDDPVLEKLAIDGVGKVFVTDTILAHLMTCTRSVYPWDLVIQKLPGGTLFIDKRDNSQLDYLTIHETSYNPPSPTEDGINNPERLGLEATMINQNFSQQILKKTGRKEMALPNPFFDEEDADGMEPASTAFRYRKFALDEDTVLVCRTELHGLVKKSQYMTAFALNEYTPTDANQNTNNNVWREKIDSQRGAVLANELKNNSFKLAKWTAQSLLSGADQMKIGFCSRATAKNAYDHVILATQFYRPKDFATQITLQEGQMWAMLRFFFQLFNKQEEGKYVLMREPNKAVLTMYKVPPETFEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC64</accession>
    <name>A0AAD2GC64_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002380">
        <property type="protein sequence ID" value="CAJ1968431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="100" mass="10690" checksum="278DA0E0D018144B" modified="2024-05-29" version="1">MPNAQSSSCSSPAQPPSYPIENSLTSLLGTAIASSQQDASQLRLPTFQNNNNNNRSSQDLSEVLGQVLEIMGSDFPLSMDEMDGFFDKRVASSPHAGAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCC3</accession>
    <name>A0AAD2GCC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNL-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS23677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042264123" description="DNL-type domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1969380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="199" mass="21758" checksum="BCE8D9EEF26F4042" modified="2024-05-29" version="1">MTLLRSMLAIALVSFLFVQANSFATLPSLTTKIQRKCLGYGCHQFPPLKQSSDDHEEIESKIPQLPAIGTSSLHQGGSSTVQAEPQGNSHEPLNDVAFVSPKFQLQYTCKVCNTRNHHLVSRIAYTEGVVITTCKGCKSKHMIADNLGSGCLDGDANIEAYFKARGMEDITRVTEEVFELEKVLNMDALVGDDGNPVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCE8</accession>
    <name>A0AAD2GCE8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="151" mass="16962" checksum="65FB62D9ECDD085C" modified="2024-05-29" version="1">MPSQPPNRSNNALVVHNPNQGRRPRPDNRRRAGGPRRPNPQWQEQDDVSAVSDADYEEDYEEPRFKYSTAELRNASCIRNQKCCIASMIILCLIVAIVISLVVQKFMKDLEEDANKVPTDPPTIAPSISPAPSLSPSVTAGRFLRHALEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH56</accession>
    <name>A0AAD2JH56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MalT-like TPR region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH56"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1950043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="54326" checksum="3EEE8D439B5D4DE1" modified="2024-05-29" version="1">MQNRKTIEGNEQDSATNLFDQCQAYLKQGNDEKAKEILERVLTIQTKDLGGDNLDLAETLKAMGDLLLREGQLDGASDKLNRALEIQLKELGENHVCTSNTYEGIGHVFFAQHNDQKAEEMFRQALDIRLATQGEKHGDTASTYKNIGDVSLSQGNFEKAEEMFRKALDINLEILPKTHPDVTNLYHDIAKSLRFQRKFSEATNIARLVLETVLVVHGEDHLDVVKAYLGISGLLGDQNRNHDGLQMLDKSIEICSRLQGQGQGDFDIHVLINALAMKAICLQKLGNIQGSTEVLTNILTITKETQGEMHSSTGDTYEELAAAYRRQEMPELALEACGKAINIRKATLGNDHFLTKNLRASLKLIRREKQAKELNEQGLAMKAQGDSEKAMQLFHEALDIYTEIVATSSTGHHKLVKLAEVHGSKMAAIHENISAIKVQQGLLEDGIAASAEALKIRRRVHGDDHADTKARMEAHRSLLKRLLENQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH60</accession>
    <name>A0AAD2JH60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001768">
        <property type="protein sequence ID" value="CAJ1950447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042252161" description="Pentacotripeptide-repeat region of PRORP domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="87539" checksum="09941B1BAD9EDBBC" modified="2024-05-29" version="1">MMLSSRSRAIICALFLFLVILEVKSFVPYKNFAVPTTSQLDAISRKGKESSRLARLRVNRDRLHRVVKSIEYYGQTEGSERRASCVLLNAMRMLLEAKTQDKISHVGNLLNKIDIVNEECRPIQERVITATSLAGLVSISTNILTNMLHSSYLPSSRAYIAACSALRQTGRLEELERLIYDLAELGTKLDTAIDVVAWNIYLSSLCSSIDSPNDPTLARIWEWMQPSVAQRLFRVTPDVTSFNILLDGAARVRNTTLVERVWHDLKGQRGVEPDIVSYNARLKASSGASSRAECFDILEEIESRNISPDAFTIDLVSNHLIRAGRYDDLQSMVDQFLTDKSERDKSKALAAFLVTLVQQENIESARNLFDRCALDEPSVSSVSPCTRHFNILLDGYSKIAQLSLSKDQLALIQKTLENPSGTFDSLDLDPIKVAALTEGRELCRMVVSFGVEQDPYTLSSMISLCISSDEIIELMNGSTAPLSPAVIRCAITYLGRLGDPSQACRVFDQFAFQSYNNRVWNVLLGALSEGAKQGNSILDIKSTISSKRHVLEGKGISSLVDGLTCADAAQTLLSAMNGMMERVEAPKPNSQSYCLVAASASQIESVDPSIAMKLFRNATSDGIPADGRFVNAVLRCFGGNLEQALKFWKEEMRMACIEHESRSRTRAIPNSRRPKKNLIAAYNGLLYVCGRAIRPDTAVRVAYAMRKEGLEPNEISLNGYKAGKRQQEKLDRHKDTNYNLGAWFKFLPKPNMIQQYESLLYIECTKYNPDNKRTSNDRRVRIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHZ3</accession>
    <name>A0AAD2JHZ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tubulin--tyrosine ligase-like protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS13222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHZ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1951756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="59704" checksum="9DB79ECFBCB1D79F" modified="2024-05-29" version="1">MMTRRRQAKGDEPTGSNTHYSPEKSRGAHYSRNQIGIIHVAIIGMVIVATIGFGMIRIVPSEIEKLLGITRTHGQMVKRAPKRKTKMACVDKAQTAVVRAFKERNYKVFYLRGYNWKALERCYTNSTVSSLFLWTKHKPPKGYWEMAQPWQRHNWIPYQNVMSSKSKFLSSLRGYEKKSGRKMDFIPESFMLPYDRKPLLERFNSSLNEPWVTKLSATDNGIGIAMLGPDSSELRTLANILREKSITRKYMDRIREEIVFTQKGDTRGEENIEKARERSKKLNDPIIVQRYICHELAYLGRKFDLRIYYLVASAKPLVVLYHDGYLRVSPHEYNDKVFESTGKHLTNLGRHNATEKNTVGFDDWEIQLKLHVKENKDGFSAAVRADPLDHIRKQIMSALANVVAANRDKGFHGHGGSYTKMENGFALMAGDFIVDRKLNVWMTEAQSSPGLGHETAMKRKMNDRLLPSTVDIIGEVNEKQMAGKPLTPIQNPGNFRLIYTDDYHYRYDFQREQQRGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ34</accession>
    <name>A0AAD2JJ34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042199141" description="Glycosyltransferase family 92 protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="49257" checksum="02593E2C5A52F137" modified="2024-05-29" version="1">MKNLPSSLHLLLLAMLYFVLQGDRKILFSWEKRKKTNAQQEKRQGVGLSLGMGGGGDVQTAATVAPQRQAEALTPQTAPPQPLEETVITSARTNADQYSISHLVVLVQGPARMLGHWKQRLRDAGVEKSVLLVYASFDKPAKDPECDVLENGQWSSFCRTLFIPDTTWTEGRNELVKYAHCEEQIREQEFRYWIFSDDDVELECHIPDDMATTTNNLNGTVCWTLYFDFLDTQMLSSQAVFYALRDAERFSEENQKGIIITAEVDAIINAFDRRYIKMLMPYVFMKKDDSWWMSQMMQFSLVHRCFGAAGIVPLFFNFVNDLHRDYPRGLELEKASLLLHQNYEQYMGVDFFRGKFGIYQYEHKEGPFLDVATAAVQVRKQLENSQASCGNLTQRFHDWEDSWGTCIAFQQRLEEEQSHPLPRKPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJS0</accession>
    <name>A0AAD2JJS0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="297" mass="32505" checksum="B238258846264994" modified="2024-05-29" version="1">MPGGESTRRSRRTNLGQPPRRLGEEEETLEQDSNRTVRFRDENLEEIIDNRTAQVEMDQGQGAAPQQGADANAANQGNNQNVANNPAQAAGNNAGQAVTPQLRQVIATEIANAIGPLMQLLQGQQQQPPQQAQPQAQQQPPAPHQQQQPPAQQIQGQQQQPPQQAQPLAQQQPLAQQQPAQQQLPPLQNPPVPQPQPAAAAAVQQPQIVMASMSTFPQGTDPMIDPKDPVHGRLNRSMYNEAKEELKTKIDGKNLSMVISELRERCSAINCTDLFNVVTTNGTKNLLKHYGEITFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL36</accession>
    <name>A0AAD2JL36_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS18703</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1960382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="403" mass="45663" checksum="9D2E49EA96990473" modified="2024-05-29" version="1">MKSFLTSVSSSISATAPPPLAFQSSLSRRKRIQSSPSRHHYSDGNLSSPFNKNNNNNRVRPRWVLSALEVAPTDETFDNEDDGGGDGEDDEFLLLENMLQDVKLDDSELKEFLRENDEMLSIDGFADDVNTLFELMDHDEDDDDEEENMRDGDNFKKIPPTLDSSELEKALLQGVVPVAAGVGSECLPGDWGFDPLGFASKDYILDIQYKLLQSLPGAEQTPAPKDRPTALILRDYREAEIRHGRLAMLAAVFWPLQEMLDRLLLDDDQFGPIVYDTVTLPYFPLLMTLFMLNLGYLDIFAKEMQEKDNIGDAYLPGDCLWDPLKFLEGAPPRMKRNMQERELFNGRVAMLAVAAYFFEEVTSGVPIVSMDANQLLFIPAYEIPSIQEWLDLQFSPSFDHYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL58</accession>
    <name>A0AAD2JL58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042210642" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14960" checksum="B0E1107B8E0B774F" modified="2024-05-29" version="1">MNYSIICLFMIICMILISSANAVEGGSHFYTLPDAEMAAKEQQQKGFRTRGSKKSAAANKDWMGAPISRQQSKHSSSNSSLRKNKKKTFEDVVVSTNTDDMIKESIRNDRVSGSSSSSVRTSSSKSRETRTFDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLD3</accession>
    <name>A0AAD2JLD3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002090">
        <property type="protein sequence ID" value="CAJ1961201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLD3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="267" mass="30364" checksum="D53F5C0AF064E24A" modified="2024-05-29" version="1">MKFFDKKRDLETFQDGDQIAGVDDTEQGYLEEAFDQEYESEDEDERDFNLHGQFDDINDSKREELLADADNDVDDMPELTVRFQGDDDYESDDDLGDEGDEEEEPIVANLDHHQENVDRGTNDIGSLLTDLEDLQEPTEEEIVFEPETPQVAKVTQSGQTYAQAAMSGLNLSQVPKKPREWPSSMSGSSANKNKNQVAPRCKHRERELKLLKNKLKSGIRTKEGSRSTKDSKAILEAKHNLCFQQIGNKMKADYEERSLHDADQGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMK0</accession>
    <name>A0AAD2JMK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS20916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMK0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="7">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1965035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="164" mass="18884" checksum="C8BFCE2E85164B39" modified="2024-05-29" version="1">MPSLIWSSAYLFLLVELVITAILVVPVPIKIRNAITRKVFQLNLGERLRKPILFIGIALAFGFVDSYSKHKYVLDMINEERNAELDHGHHLPHVVHHEKEKKYKAERNMYLTGFALTLLFVIGRICQLMQEHVELENELHPETAVKKKEPTASPPKKPADKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNP9</accession>
    <name>A0AAD2JNP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="48"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="270" mass="30247" checksum="4E013F4A2FBCFF80" modified="2024-05-29" version="1">MVATREEVLGVFFASIIGFSITFQLSTSILKRLVQKDGFALEPKHHHTLVSHGPSYVCSMIHCVINGYCGIVQLIGLRDAPSQVKLVFPPVPEEVALYIRGVELSNAFFFAFLAFDLFHVLRLYPKLGGIDTVAHHSVFLTCSIINGGYQILPYPFSWLIIGELSTIFLNIRWALIKTGRGNTIFFQGVQYAFALTFFITRVVIYLYGVFELFQRRETLFEIVSTGRVPGIFMGITLSFVAAGSLLNAIWFQKIAAMAMLKQTKKDTKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUE2</accession>
    <name>A0AAD2PUE2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12288</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12472</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="422"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1950200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1344" mass="154125" checksum="548C35D57DF1DA40" modified="2024-05-29" version="1">MEFFDTMDDNWTAYYTRAAYKRAKHMHYLAESMNEDYEPLTKETWIKRELNRVHPNKRKLNHPHYRVRNKLLYAKTTLIYVHETTNSEGEATHHNNCKFDTDSGKVGIDNRASACISHVATDFEGPLVPVKRSIKGFGGERVWNVFKGTIVWKWHDNEGQLHRFSIPNSYYVPHGKCRLLSPQHWAQTQLRGRVTPMKKLSETTKDGIGESTLYNRCQVFWDRRQYTMDVYLGEHDNVATFYLAPGFKNFDLFCKECKIDTNDDTPIYAMPAGVVSDDEGGEDDDDDVPPPTEKNDNNTSFLPNLLRPIRQLNPLKAKQTTPEPRHTTFDLDGRTTTGDRPPVVIDEEEEKQATTPAQELLRYHHRMAHISMAKLQNMAKQGIIPRRLANVHPPTCSSCLFAKATRRQWRHKRRKHWTEKTDVRTPGQVVSVDQLISPTPGLVAQMTGILTKKRYTCATIYVDQYSGLGFVYLQKSTSADETIMGKKAFEAYAKQHGATIKAYHADNGVFRANKWVDECRRLEQTLTFAGVNAHHSNGLAERRIRSLQDLARSMLIHMNNRWRMPGIAHLWPYAIRMANDAINEAPNLRDEKGRSPLQLFSQTDIQTHNKHWIPFGCPVYVLDPKLQTGQGFLNKWEARSRVGIYLGRSPNHGRNVALVLNRLTGLVSPQFHVTFDKGFNTVKQDKYDTHWQMRAGLQVPKKGAMHPSNESTNKLKRTMPEPEGVPQQSNKRVRMETGVSEPMHINDDDMIGNSTPGETNKLQQPDESTSPVPHNEEEAGRSDPPMEDGGERQPESQQVPNTSSISHPAETILKVMAAELSSATKNGIEGEIFCFEAMFPAYSGEAEQDPLKIFKATSDPDTMYMHEAMREKDAGEFRKAMKKEWEDQLKNENFSIIHRTSVPEGATIFPTVWQMKRKRDIRTREVKKYKARLNFDGSKMKYGRDYDQTYAPVASWNSIRTLLIVSAMLGWKTKQIDYVLAFPQAPVERELYMKLPAGFKVVDGNSNEYILKLHQNIYGGKAASRVWYQYLTKVLVDKLEFKKSNYDECVFYKGNVMKPDGSIHLTQPHLIDQILKDLNMQEDTATRPIPAASSKLLSKHSDSPEFDGSFHYRSVIGKLNYLEKGSRPDIAYIVHQCARFSTCPKKEHGEAVRWLARYLKGTKDKGLILRPDRTKGLEVYVDADFAGNWDPKEYEDCDTARSRHGYFINFAGCPIVWKSQLQTEIALSSTESEYTGISYSLREAIPIMNLFKEMIKYEIPIESPIAEVHCRVFEDNTGALEIARVHKFRPRTKHLNCRLHHFRSYIGNGITIHKIDTKEQPADMLTKPLNAELLIKFRKMILGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUE7</accession>
    <name>A0AAD2PUE7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="136" mass="14780" checksum="F906E912039143FC" modified="2024-05-29" version="1">MFSLQLQFPSLPDRPTKRSVQHELRLFPAKRRCRMVSSVIHESVGEESNANGWIDVFIVPGDGSNFPLVLSDSMNEMLASADEFAINSELHVIPEPAVAEAPRRSPSVVESQRRAGSCATGDPCSAKEDVGDPATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUH3</accession>
    <name>A0AAD2PUH3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001764">
        <property type="protein sequence ID" value="CAJ1950382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUH3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="331" mass="36685" checksum="04273575B8CB8E27" modified="2024-05-29" version="1">MNSNFISQLSCIDQINPLETETGPSPEKAEMNDLWLGGATDGKYTGPIRIVLSYCKGDLAWLSAFILGFGVQSITVVSKCGVSPPTNLPIKDKEFIDLPNAGRNDHTIAYSMAKISAEESDDDAIVLFLKDNIVVHQKANPRSLYELLRITAKKGFGCFQELRKGMSFYHQTDVLKILNMTKYGGVPHSTSDGRRVWNDSKGFKSPFKNLGQWLESLDISLPSPLTPVCYGGIFAAKQTKIKSIPKVKWEAIAKSLSRGDNIEEGHFAERTWAGLLSAPLSEEEQWSIIGKSSYVNRVAAKDGGGRLGALGNYKLNHHPETNRHFYQEQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUP6</accession>
    <name>A0AAD2PUP6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019099">
        <property type="entry name" value="Uncharacterised_PGPGW_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09656">
        <property type="entry name" value="PGPGW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="48207" checksum="47119810EE47FE40" modified="2024-05-29" version="1">MVSADIDTAPSDEHLMEGWASKVETVVEDECDLPVRAEESRDPSSATGTQETGESSHLFSPEAESSDAPVTPSSSHGGSWLQRDGIETAKPSSGNFWFRKKAKSGQGSLAAGKDLDESARRNEEKGAAQQNKPWWKAGREVPQPIDGNKHLNGIHRQYRGDSSWVPQADPQGETGIVVRSEPVNVLWDLMSRAIRESALWRAATKVHDSSKAAAEERAKQGAAVRHGFRRFFRKRKTDDEENIEAEKKAPAPKVPWWSRFRRNRSNAEQPSVDGETSTAIVPYQPEPHPVAAAMKKAAAGVAGTCMVIVGVPLLLFPVPGPGVAMIASGVYVVSTEFEFARSWLENVKTRFGTVFDRLGIEVATPEALAAPKSSSPVLLLPPSLPPANVDGEIKDSNEEEESDDHKKEEGIDSNEVHSALEAADGDDSIEEYRKTEEMIIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUY5</accession>
    <name>A0AAD2PUY5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="170"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="512"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="932"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1060"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1262"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1482"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1541"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1792"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2061"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2129"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1348"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="948"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="979"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1063"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1273"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1578"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1618"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1670"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1793"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1803"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2065"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2094"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2129"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2156"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2167"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2188"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1953378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2245" mass="260303" checksum="A42AE73998075B26" modified="2024-05-29" version="1">MNRQRVSRLPRRSSIQISNQWNKQTVATADPLYDGADPKKWFVKTQTFNGKFLGGFNKEEVNGQLITDGIEKFKNNPVKYMGIMYITEEMKEPKSNQGYALILREKGSKVFPADVGPDGRFTIMTQEYRRLPPLKSDTLPKLCRDDYTDNMIYKGKKLHTKANKPLMPGRGMGLLDQPNMKLIGTIDPSDVKQGIIADCWLLSGISTLAEFEGGIQRLFRKTKKFELMPFDDKPNMYTVTLWDISTWTEVDIVVDERLCSRPDGQNRRGEMKLLGAKPSDDGELWVPYLEKAVSIHCGGWDKISYGANCNHAWAILTGVKEQCTILRVADENSNWGCYAKYDPFSKKFAELDNDPWKGFQSVYTVPWPETEGAGFDDFKDTSELNDVQLFGKMCDWDDGNFLMACSSKGQSDRENTDGIVNKHAYGVVECKDNVAGTGMDMIQLRNPWGKGGELENGQFARGKGPGWKKYPKLKRELNPDQDSPGVFWLTRQEFFKYYDKIYLSAGDMSEFLGLKPPKRGKPKDEKEMETDNKKRKVETPNDKQTASNASASPVKKTKSISKPVSPKKVSPIKAKPKGFVKVEKNIPKKGKGKKGASGFFKAIPSSKGGGFQKMIPRNKKEEMAQAKLERETKEKEKLEKERLVQQELGKERQEKEEAERQRQENEKVEKEKLERLRLEREQQVKAKQERERLERERKATLQLEKQERDRLERESKAQEKQDKQERDRLDRERGAREKKERDKLERERKTQERLVRERLQWEQKEQDRLEKETEAKEKQEKESKAKLQPSSNAGKFKRPAKKVESPNHDTDRGMEDDSMKLQEMDSIIADLQRRLDEAQKETTELRSQNTTLAAIQEDLEDEAMAYEGQLETKSEIIDTLTEELNQAYETAKPQDDAKELIAKNAELREKTEELSGKTAEIAKLKKELAKARSNALSQSDQKTSVMQHRREIEEKNAIIASMRKEIDNGKRRTSALQDKASELESTKQELEIRNKGQKRKIEQLERDDGASSSLRADLQKAKKTIQTLSQGKIQSQRDLAKKEKRIDFLRSELREANQAIQSLERKMGGSRDRDRVRLNQLKKQLEDKEAELHSKDAKLKSGERAGVESRKRLREKDDRINSVLNQLQQSRKEGRVLEEKNEVMSKKLKSNEHHVSFLNSQLEEAKHLIQTLEQRTRASRDREVARLRKQLETKQEEVNTQKHQLQQAIDSAQSGRIALRAKEQESIDLRGALRQLRGEFQSLEQEKNDIYVRENRKVKQLQSRLSTTEAALETEREKRKQSNDRVDELEEELHRERNKRQRLNEEQVNYRNPTEAPEADQVLKDKEDELNFMGKKLRRMTLHQQQSSRHLEQEMIHKEDQISELQQQVDDLQRENEALYVKNATQKSLNKKLVELEIELDKKNSIAETWKEDVVSLQNAMDEQKNRIERMDMEMTHKDSSIQLLEQKILEQAGIIAQKSTGSAKYAKVVADLNRELESAQEQLKRRRIESTSEGANIKRTDELEKELREARDDSDASRQTIKLQEADLEEKEALIQSLTRKLTERKQEPSLASERAQGRELSLGAQRVQDPGLNAERASRQKETTLTIERVREPRSAAEGAREASSSWERLRGPTMTAGSREQSSTTERAQRPRSSAPEDLPYQPPDVKTSLESEKESEENQQNAKRARSIEKVHPPEHDMHLRKTSIAEQGSPESQEIDKGMRALEHLQPDYGRLPSNPNLHIPQNESFDNNGIVYSHLHAPELPEYESQTKSDPPARGIATEADQVRDRGLVATSPHLNHLDVFPLQTDDENRARRGGFDEPEGEKWDDDETEEHDFIESQNAEEHRWNEKSDLQALRLRDETRIKHSHFDESIVAYDEDMDMHKAQPSAERRRIHRDFDEANDMEKWNDVSQMYELEDRRKTNRDIDEASDMDEEKYIGDPRMHGIRTRGKNRLGREDFEEAKAIGDEEWNEEFSKFTSNPRDHTRRRHGDYDEYSLHEHHKWNEEPDMITSNLPQERRMRQRRDFDDPIGMGDEQWHEESDLQTLRPMDESYRMRRDYNEPRIMEDGKWNGELGMYIKPTPSSRSHQEMNQDPSHMARSRRNTAYGQRKHMESSTKDRSPWYFDSQSPIGNWNEGWDSKLRRQPEEGLRESHGARRLDPISDAPKTRKVSRYGDGDGDSDHSTSNAHVVGSMNSWAESTGPRQQERLRSQRIQGKEDDGGPDSINDYLARLFEKVQATKSELEATQKRLNHTVGRHLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW71</accession>
    <name>A0AAD2PW71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="813"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="902"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="975"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1959493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1471" mass="162906" checksum="6AE6BC8D73EF8434" modified="2024-05-29" version="1">MSYDISSYINTGVNPPAFASSSNNSSPNMMDNNNEVSNNNSNNSNNNNSNNSNNNNVTTNALQSAKQQQLKQQEQLRRLVVTEEEQRQKRIEAQTAMERYRAYLKKQASMEQQVYQTLEAQQDDDKGQDGQGQDGLQQPQSRVQPLPHRHYSQQRQQIRQQKQQQDNDNDNNTNNNNNNNNPPPLIEVVRNATKPIIISQPNASNNNKQQQQRQQQRESAMSTVSARNGNENNTDISNNIDINSPNLSPSGLPESHQPSRGSKIARVDFSGSITNGDNEEVIDPATIWQAFASASDTGYTASGGGGGGGGVDLVKDDEKKKRNASVMQAMTTTTTTTTTMPSLPTALFIPPTRPAPRAVPPRPDSSSGGASRTSTAPHNTTTAPQTMRNAPNTKTTTSMTSTSFNPDTLVSVHGNKNISSFGKTPTLSMFYPSPARSTNSSSSNKVETRPTTTTTTTTIEKNENTIDAPTVQHQSTAAANKNTRSYQIDQQQQQQQQQEQQQQQQQQQQQQQALFPQEQQFQQQQQQQKQQKQQHFQEQLQQQQQHQQQQQQQQQQQLFQFQSIPSPAPTQLPQQLLQVPSTKRRPAKDPVRFATTEESPPLNSSSAAAAATTSSSGAFSPRPPRPPPPPPPSSSRQAGSDPKPPMTSILKSTNTPNTSGGGGGGGGGGSSSLSNNNNNNNNTNNNTTNNKKFTGAASMIVQERKNDMEHRRPAPPPPPPDPPKLTYWETKLESLQDWWKKPAQYRPLKILQLIFGLYIVIMSFTYTGTLGNVGGLVDPKSGWIIDPSSAENTDKGVILVNGDFRAVVAESTFQMIALAISRLSAFTMYPALVVVFFSKFRGTMNFLSFTYIGQLFIASDLHDLHVYCGHYILIDGCIHTFFHTLRWAAQGNLYLLYSNPSGISGLIVILSTLLICLPMMYGKKKVVYEIRKLVHYLFLVFALAMCFHVPTSGFPNGGFAPYVFTILLVWWFLDSIFVQWFMTEKIQSSRFYVLPSGVQLTMAVSQRFQSWGTGGYCYVCLPWVNPYQWHAFSLFENPADPSERQIFVQKLGNWTTQVHSMLGRETSRPVWVAGPFTSPYGRADNFDNQILVAGGIGITPALSVIRHLKDTRRCNLIWSTRDRHMLEFFIKHADLSHRGWNLVFYTGKEQLLGIEDVVVTGSGATIHIIRERPKLHYIIPNIIYGIESATSVPEQFIPDNKIVAMELLQEKLTELEAEPDLDSHEKLSELVNYCDELGYLFSDLISTLPNHEELTKAPTLASVGNKSNRSVLDAILNFNGNTSDASGGGVDSDDDRRNMFAGSRGSKGRASSRNMLINASRRKLGGSSLRRRRVSFASSSIGDERRSSGGGGGGGSKGRESITTSTWSTLAASIQVVKTMKGLGGLGSLGEDSEELDPETAIMPSMFDQLDIPFKPWDYNKEAEEYVKKMGDDEVSTWGVLYCGGKSPLYRALKKAARKANVEMHEESFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWI8</accession>
    <name>A0AAD2PWI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Solute carrier family 5 member 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS18818</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF3">
        <property type="entry name" value="SODIUM_PROLINE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042269639" description="Solute carrier family 5 member 8" evidence="15">
        <location>
            <begin position="26"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="684"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1960636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="75927" checksum="84B00069CE6CBCC0" modified="2024-05-29" version="1">MSSSSSSAVLGTLIALAGLLPQVASQCIGDETINTQFAEIFSNGTSTTYEVAEGSCCQETICAIPCPEVVDPPEKVFGIVVISFIALTVLVGFATVLCVKGKSENYFVAGRTLPLGVVVATLASQSLDSNAILGNVDLSYKYHFFDGACLPIGLGISLLLNGAFLARHINNDGALTLPDVYARRYGRVVEVMVSICTIISFLCLLGGNLVGLGAILNYLLDFGAEEAIWLSAALVLLYTIAGGLFSVAYTDVMQAGVGWLGALSFAFWMIKNSEFDAPPPSIGYPGYSYPNDEICDLYEGVPCTNLEGACCYNEAKWCPSADDCKVDNGAYPIGDLRVIPEAMTDAQGLTPFPNAILFNWATIFVLGFGNLAALDFQARCMASKDGKTATLGCFIAGVLTFIIGIPFAYMGAITRVFYGPDSARAAFETDTCSEILALPTCGLWLPDSEAFIKLLTHEAPTFLGAWCLVAIVAASMSTCDGAILAMGTVFSHNIMRNFGNCISNDNLLTIARFASIPLTAISATIAAYYKSSHSLGATGYLLIVAFDVVLASVVVPLFGCFYTKKPSPLAALCSIIAGILTRIILEFTLPKDGFLLAPFDGDEFLNYGTAASSGVPPFWDFPESDRWDPSAEQCVQERYSDLSGADSLAAPLVGLIVFVLVQFLERNGPIIEFAEGGLMSPYMKEGQGLDLEEEPAKEVDSAEPESAEKESDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWW0</accession>
    <name>A0AAD2PWW0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWW0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="159" mass="17546" checksum="E6176568AED3B911" modified="2024-05-29" version="1">MDCHHKEITPIFKLPEFTTKEHLKSNYTQFTSATEPLPNPLSSPPANNNNLPLGNQAAVAPAANLNPYHNAAAAAQNQNVMRHIEDTLAHIWRSIRTCFLDAWTAYICLQKDNDNALCMKKMLTKLLTNEATAAAAMQVDQEAALPPATLATLIQREVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX47</accession>
    <name>A0AAD2PX47_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX47"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="105"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="364"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1964913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="454" mass="51901" checksum="F9160289C953F392" modified="2024-05-29" version="1">MANYSMIQEVILVDARSDSMTISWTKVEEAVCYILEFRTVNPLEPDWQRLAEDIQGTSSRKRNLMPESQYFFRISPVYEDDTVGPWITHPESFETLTQEQDEDYAMAAPIVTIPAEPNALIITWEEVDEDVHGFEMQMRENKGGAKWFGFQVSSVSSEVKKKNLTSPWGYQFRVRPVTDFDEPFSPPSNPVQPRRGEKYNRNRAQPAAAPRSARQASQQYEEQGYAEEEYYDPDATPQRQYGDFKEYCMPAPWFKTAGEGAVLICWQRQQGATGYELQMKEIVPGYSQEEGWETIAARLSGTEVKKKNLWSANGYQFRVRPVDGPMSGRGFSNHSNPVVLPQTSKMRQARTTAGAKLSHDVIHAMPAPWFKGANEKNAIMVVWQPQARVTAYTLQMKECAQGEQWQTIAERLTNTEVKKKNLYSQNGYQFRVKPLDGPNKHKEFSKPSSIAFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CB50</accession>
    <name>A0AAD2CB50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1900425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CB50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000117">
        <property type="entry name" value="Probable papain cysteine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042033162" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="48"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1900425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="355" mass="39335" checksum="516D99EE1270B8E0" modified="2024-05-29" version="1">MLFSITLLLAAVPVALGRHDEYMVLEGHDVREDYHSPLPHTYISEDELPDNFNWGNVNGKSYLTHSLNQHIPQYCGSCWAHGALSALGDRIKITNSSKDEIDLSIQYVLNCGTHMAGSCHGGSHTGTYQFIKSKGHVPYDSCMPYMACSQESKEGFCQYVDTTCSAANTCKTCDTFAGMGGACTEIDYYPNSTISEYGTYSFMTSPKDIVHKLKSEIYARGPVATGVNAEPLVKYEGGIVTDTKLWHMMVNHIVSIVGWGLDEETGNDYWIVRNSWGQYWGEMGYFRILAGKNSLGIEMEVAWANPGSFTVNNYPCFENGENCVKTAYYKDPSKDLDSLKLRLAGEKTKKGGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBT4</accession>
    <name>A0AAD2CBT4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1897613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBT4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1897613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="153" mass="17290" checksum="E0B1F45FDA48874C" modified="2024-05-29" version="1">MATRVVSLLEMIASRGGIVKTTNAPGAWAIIAQWRRYFELKGEEVDEEEYTEEFKRAFADVRMEQKSEDQQQQLKETILAPIADPGVVEARKYFAMQYLRSLTQESQSGIPTPSSNPFPSGPTVEERNAQAERILNNPDLRIPTGDEFLNLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC57</accession>
    <name>A0AAD2CC57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS25</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1889108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CC57"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031142">
        <property type="entry name" value="SPX_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45978">
        <property type="entry name" value="SPX DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45978:SF7">
        <property type="entry name" value="SPX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1889108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="325" mass="36959" checksum="E1EFC0D809E900FF" modified="2024-05-29" version="1">MKFCKNLQRVVDISDPEWAPYWPNYKMLKKLIKELPSLVPAEDAKPTPEPPKNNTGSSQKPQNNPNASAIGKSPGEVAFFKLLHSEFKKVTMFFERASEEYKIREERVQEGMAISKQANSIMVNEKWSLMAKSIHRLYKDLLLLETFAIMTYCSFSKILKKHDKVTGYETRSAFMENVVNKANFTHYPHLLEMISRSERMHEQVSQILLREGKEGLYEDERLFINMINRLNEQVLNGEDSNSNAIRKDTTRRLSLTPLANKKESSEASTTAAATSTLRAVLEDTQNANNAKIEASDDGGSHHHHDNKRPAATNIPIAPDAKRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCN5</accession>
    <name>A0AAD2CCN5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000083">
        <property type="protein sequence ID" value="CAJ1929503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCN5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="117" mass="14235" checksum="3DEE5D721C512C92" modified="2024-05-29" version="1">MPKRKKTTKPKKLKLNDKEWGVFFARHERTYIPVTKQMRQKEPRLIYMYWVDHFGEENPIKVYEPGETYVERKKRLEAKHDKHKKNLHERMTTAEINAGEQSTLTDCFFLPKKKKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDH1</accession>
    <name>A0AAD2CDH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS2132</name>
        <name evidence="8" type="ORF">CYCCA115_LOCUS2134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1930879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1930883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="361" mass="39858" checksum="30AB47E2E151FC80" modified="2024-05-29" version="1">MNLKRWLLSEEEDVNSPSILITDGGVSTHLEAKLQHKNQEFEHQSLWSSSLLMTEEGRKTIQEGHDDWLKSGSDIITTVTYQCHYGVPGLEMVVTPTQMDQMIQDGISIAKECVAKTNPRKLVVASTGCYGAALADGSEYTGNYGDMDRTGLVDFHLQKVKRMMAQKPDGVAIETVPSLEECHAIGEMLQSSKLTTLKENESQIACWVSLACQNGTQLNDGSKLWDALEALRSADDTTEAKYIHTIGINCCDSLHMPALLEIVTRHMATRGPKRGIVCYPNSGEEWDAANDSWKEGTGCSSAHELVERLVDAVHVIESTWKKHTAGAMPKLILGGCCRTSTQAICELRVAVDNWEQKQAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEL9</accession>
    <name>A0AAD2CEL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000147">
        <property type="protein sequence ID" value="CAJ1931363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEL9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="185" mass="20679" checksum="73E9F8B58B657F20" modified="2024-05-29" version="1" fragment="single">MIAALNGLDLQCADIQNAFLTAQAIEKCYLVAGPEFGEEEGKVFIVRRALYGLKSSSAAFRSHLAETLEDLGFSSSTADPDVWMQAAVKPDGKEYYEYILCYVDDILCMSMKAKEVMEGIGRVFKFKKGKIEPPESYLGARLRKKTLDGHDMWTMSSYDYVVAAVKNVKETLKDSPKWKVPKNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEZ8</accession>
    <name>A0AAD2CEZ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS1891</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="11">
        <location>
            <begin position="37"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="203"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="286"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="430"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="885"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1930289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1377" mass="158412" checksum="E48CA949405987A7" modified="2024-05-29" version="1">MWKVSFCSLGDDANCGEWCLLTKLKKTCPPIPLHDLGRTTIIESLKFAVCGALPPGNKSGQAFVHDPNSIGQSSVKAQIKLRFTNRGGRTMVVLRSMELAQKKKNMTFKQLDGVIRMTDEDGQRQSLSHKCSELDRQLPVHQEDANWPLQEGAVLKKRFDDIFDSTRYTKALEVFSKLKKDYTSKVKDHKADVASYSSHLHAAQGFQAEVEKYSDQLELVEQEIEENTEELRRTENEEKRLNEILDQLDEIQLDVDDKSNSLHTLTELANKTRKMLEDDLTEEKSARELKEMLRDFDSKLNDQIDEMDDLQGEISRLKNQISELTQEESKLQSQLGRYQAEKDAQVERQTLRCEKVIQGNNRFGLNSTLTAFSQSQSMTQNASFLEASGQPVQLEMSKTDLDDYFRALGRKTSELDEDLNRKTKLRLQSEDESQSQLVDLKGKLQSIKNEQKKLNHDIDEAKKEYEDVSRQVSQISRMRKDDVEDARNNANRLAAQRDKLNKDPRRSQIATEIRSFEDKSDRLKRDLEEDSDALRDLRETAEAQHEITVLKQQIARDIEDLKESIQESDFALKSRNIDIPTIELDGDEIGDGLSQAMGKLTEDVSSKFQIADSELRKAREQFNALQNVVAEKSALLTRDQQLVHNKRDKLASLSSEGGIKKVENVVSELRQFEASNAIATPPELNETKPKELLTYLEERLEAEEAESLEGIQPEVISKIIKRLKNKAKRPGQKVVCPCCKRGLDDQDSVQVFSEQMKMLMGSESPLLKDGENNKTAKSQYQKWRRITTENMNDILEYRRIANEVNDIEHNCTSLETVVEERKEDLETTKTARDEILSEVDGLRSLLESCKMWQGASDRINLKRSQAMNKCNTLSISESVHSGRDLKTVERDFAEKTEKKDEYQEKISRLNKEMTKINNQMSSVSKQATDAENLAREKEEKFAGIRKLSDRKKALNERISKTSKELLELGDNIKPIKDKIAKKESEREKMRKHTMEEENEIRKTTEQLKMFENEFRELQRQIDDFDSRNEVNALERIENQIEGFQSKRKEKEANVAKIQPHLERLKKALDDQERHKKNLNENINLLDLNAQIRDLERELENLQEGTKQIKGRDTAKDDIDNLQRRKNKLAQQNARLEGRRGEIHENIRSFKRKLSQPEYRSVDEEYRIASIKHDTTEMAVRDIGKYHAALDKALQRFHSLKIAEINTIIRDLWNLTYKGEDITSIALVSGKDTGSRSTRSYNYRVVMTKGTTELDMRGRCSAGQRVLASIVIRLALAETFCVNCGCIALDEPTVNLDYRNKKGLAVALAQIIASRAKQRNFQLIMITHDEDFVAIMKTELASQTGFSMPEKYFQVRREEGADGKFYSKIDAIDWEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFF9</accession>
    <name>A0AAD2CFF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000257">
        <property type="protein sequence ID" value="CAJ1933248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39454" checksum="00FAB252158583E6" modified="2024-05-29" version="1">MASFDFDLEQQYNSDNLIWVSSTRGGLQEPPALDFTQDRNGKIRVQQVLSKFQQSSGIIQVGFQLLQIQGQEVADYEGGVDEIQKVIQESLSLEMVLLRSTTDIGSKLKASETCNKDNRISVSNDNRTSDKKIQNRPKRRGTIHTPGEGWVKIVPKPMEDPFASLGQRYKYNNIAWACNTRHSLRQPVPLQLIQDDEDCSTIRIHQIDPNFQEATGLQVGQQVVQLQEKDVDSYEDFQEIKDIVRESLKLQLIVLRSTAVKATEKGNSSTTDNTEIITTKEEEESIYTATSSTEFTVDESAAEEESPHQEEPQPASDQLLVVVENPSVAVEDPSLVVKEPVSMPIFDDPSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGH3</accession>
    <name>A0AAD2CGH3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PsbP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000324">
        <property type="protein sequence ID" value="CAJ1933997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGH3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002683">
        <property type="entry name" value="PsbP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31407">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31407:SF16">
        <property type="entry name" value="PSBP DOMAIN-CONTAINING PROTEIN 7, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01789">
        <property type="entry name" value="PsbP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042219299" description="PsbP C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="PsbP C-terminal" evidence="3">
        <location>
            <begin position="166"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1933997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="356" mass="38104" checksum="16C44BAF7241BCE4" modified="2024-05-29" version="1">MKTIGEILLVAVCLQSSLAFQAPVTNTASFSRLSPPTSTSRHVSNDDKQVVSPISEAANNDDSNTPSAAPSSSSSSSSSPAATEPQEFRRVVDTRPPPTADQMMLALGTNPRRLLLGNLSAAGIALAGNFLGVTSKLLTAVPEEVVEKTSLDTYYPRGDFKRCRSRGYTFVIPKEWVADTFVELAKAQRRIQPLDYTMSGPGSSRQQQQQQPNTLPDAAYGPAGRLNSKGVSESGDTNVSVIVNNGLKGFSLMGTLGTPQNAAEFLLSRSIAPEGSGRVATLLNSFEDKDRNAYQFEYILDRGSRGPPLRNIAVIAGSTKGDAFYTLTVVAPATQWEKEAVSTKLRKIASSFHLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHW8</accession>
    <name>A0AAD2CHW8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042227685" evidence="1">
        <location>
            <begin position="27"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="326" mass="35771" checksum="96EC2FF8008063E5" modified="2024-05-29" version="1">MFHRIFSPQCQLILLISLTSVIFASCQQCEPCTRNDAGEVEEPGHGGSGAFNCDIAAIEAQSFDNGTAACRDHQLMMWQRNCCPDPPSNHCSMCDTYNGDKVVPRFEHQQFGSPDINFTCSNVAERITYLDRDGIFSEYGNCDHTERGRARAWCECEGTFPDCTLKCPDGSDIPDPNKADPLFGETCARWMFETTTLPQEGCENIEDSLFFSAISFCCNLPPPKTCSICPEGEELTNSTEEVFRGKTCAEVQEYADWLPDDSCTGWFSRLMDDPFDPTAKCCVVSLNSGGGATDDTTTATSEARGGATLGLAFTLLLLILPHVVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI43</accession>
    <name>A0AAD2CI43_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS3444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000302">
        <property type="protein sequence ID" value="CAJ1933756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI43"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF64">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042209288" description="Phospholipid/glycerol acyltransferase domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="8">
        <location>
            <begin position="182"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1933756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="362" mass="40653" checksum="A587E390B2BF1855" modified="2024-05-29" version="1">MISMQRIFLAVLLIITQPIFCNSFSSNHFRPLQCGRAALRVKADFESLVQPKSSTRFASSTALRSVYAFSGVDEGVDEKVGKFRPGPRISIGSLKLNWYGVIWGIIGVSLGIVWWLSLAAYQAFQFLTRQKFDPQRRIPVELGHLWGTVVLRLTNCYPVVIGKQNLKAIHKRDKETKKKTTVMFVANHASWMDIYYVGVSLGWKNYKMVAKSELLKVPFLSKSLRVAKHIILDRTNLKSQLQTYKTGVKYLKDGVNLVTFAEGTRSDNGRLGPFKKGAFRMATATGACIVPISISYAHKVHPKDYILPVRMGRRIPASIHIGEPIETEGKSEDELAENVWCQIAENLPESQKPLVGTPRSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIR4</accession>
    <name>A0AAD2CIR4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component EXOC2/Sec5 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS3734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIR4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="420"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="320"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1934394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1205" mass="132776" checksum="4F6B3E4D4DABC882" modified="2024-05-29" version="1">MAEEDVAEKASQEIKALLRRLDPEKTSHKDRIRRLTKFKNFVSGEAGEVPEFYDDDIPLLLLGSAVPAALLGDDTDILGENVIGLLQAAGSPSVEHDQTLKRSARHAMSLLKYLLCDFVEDGDEGGENSLNLFAQCFCSLPLDRYQFMSLDLHLVGDERGGAKDDACAIMVLLLCNHVQEDGETPSPLSKEDLLMDPSAIEAFEIWCASNVSKDQRKKIKKNAEKRTEALADVDDELENEYVESDGEESDFDEDDDGAFAEMKRKRKADKKAVMDAVHSGDMSKRRGPALRWEDSQLYKEQQARIAAHQKMQEQEGGGFHDTVTDNLRLAQEMAEREEEKSKILRKDPLGLQGADFDLRTIEKEQVDHLEQGLLELQEEIRKGDVGGEDSNVLRSKKESLEFILDGIVGVGGTSGGISGTGHSVLPTEAQFDPILFLTLVHRNASYDELLGSMNRLSTDIHNQNVQLQSMVRENFALFLRCADGIDTFNETTLSQAGPGLVDRLNRQDALAESCAHQAKKSFKPLLDNANEVRKVQSALAVLQRVAPMLQAPYLMRQHVENGRFSSALKAYRRVLVIDEHCNIELLNHVKDQAAECAREARRELEGRLAQDKTSVQALIDAIRDLGELLELDIPHDPKESDKVANARYKVPNMKSVGVFSIGGILVNIRDHPPALACMLLQAAHFTHLVTTTIEEADNTTIRIFEGESLSSQKLDGEKKEDKPEPAPKKTTSNNQWKYDVLEARSIATIKAVEVISLWLPRLLQVARAAHEDEKRRAARVAKRNATGVASTLSPFEVLITNVAPSISRVVEHAAFCGLGSAPRGSGMEIKMTFGKRSPEKLRALLKSPLPPSQSSRVGKELADMVKVLGDSSGIVNELRPEDAAGASQKVSPLDVCKTLGDQSVMTIERRRCIYAFDICARGCSSRATGSGKFDADALLTCLKTLSEELTRPDQCASEVEKGCELVIRKCCDGLASYVRDRGDAARLSAVAECADVLLNRMADVVREVGNLTNNAETVEEVMMEDIMGLEGAMFDDFLGSLRFNVTSCCRMGWLDVKSESKAAANDSPSMGFPPYLSASLLAIVRCRAQVEQALGDKVRRSEGAAYQHIAMATVAEAVAEGICEEIVQRKTKLRVRQADRLANELQFLLNTLKRYLKRETVKLVDTTRAMLVGKSGQNGASAPEGLASLEELERLGRVYVLCLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJF5</accession>
    <name>A0AAD2CJF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS4877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000502">
        <property type="protein sequence ID" value="CAJ1935721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052788">
        <property type="entry name" value="RING-type_E3_ligase_ATL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798:SF97">
        <property type="entry name" value="ALCOHOL-SENSITIVE RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1935721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="221" mass="24928" checksum="8E84362160367589" modified="2024-05-29" version="1">MPRHILPGVDGDVLHDDTAFVSTALLTLLVLMTTLEAVVLIVCTVYGWFKFPFSDFRWIDEEEENDDMLTAGVDASGKAGKEVDRHVQIADSLMEKVVSDLHGQQECPICLNEFQCNEVVVTPKRECGHAFHNKCLHRWLMAQSSCPCCREKLLEAPVCERKHTHLQHHHSDENHLSSSMVTSSTNDGSIPMSMAMPWTTPEARPSYVPIEEAWGFCLFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK87</accession>
    <name>A0AAD2CK87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000569">
        <property type="protein sequence ID" value="CAJ1936859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="107" mass="12348" checksum="C41189710D6EF214" modified="2024-05-29" version="1">MCHTTMLMPKPKGMASFKRGGTKSQVQSVSGNAKWKTMDDSEKKTQILCSVKILSWLRKDLVDCILSDKKEQENETKQQDEPKKKQTPTRSTTRKRRKLGHEEPKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKC9</accession>
    <name>A0AAD2CKC9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MIS12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000580">
        <property type="protein sequence ID" value="CAJ1936955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKC9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31994" checksum="CA377A48875E1D08" modified="2024-05-29" version="1">MAIEKTESTLSATGCFKSEVSVDERLFGSLNSEIADALADYVRKAIIEGVESLPLVTDQEKIFALKQKIEGACMRNIDIMESYGSRNIFTLRNYTRRRQLHVLHASNPSLREVDMTEGNTQVILDQSALIILPTSAEMPSLEQMNQLERELVQLKERLNATRLLRNELASKYHGLESAIAVSNVAVTALLEISTENVAFPVNQVVSKGKDLRELTNECKEMIHQLGTTKKARNNDVENDEIPASMKEQTKRKRLSMEDEYKLDRKVLQSNTVSSLDALRSILRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKQ7</accession>
    <name>A0AAD2CKQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CYCCA115_LOCUS5816</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAJ1937784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="663" mass="72229" checksum="8AC193BE0EC4D8B0" modified="2024-05-29" version="1">MWMSKSWIRASSFSSSTKFARLTSGSTYSIGRGAVANSKQRHPDLKRLSSSLVTAANDTTVTITDKQGNTPLKRQQPSASSVRCMSSSEMVDEPRESMAFDVLIVGGGPSGLSASIRLKQLNPELSVCVIDKGSEIGAHILSGNVFDPKALHELLPDLKDNWTEEFQSSQGANATAVKKDEFKVLTETGSYTIPNILLPGQLHNDGNYILSLSQLCRWLATQAEELGVEVYPGFAASEVLLEAGGVKGIATRDVGLAKDGTPKETFERGMELHAKQTLFAEGARGSCSEFLMDHFDLRQDGIMPQTFGLGIKEVWEVPEENLQPGLVQHTLGWPLQSSPTSDVFGGSFLYHLEPNMVLVGLVVGLDYANPYLNPYQEFQRWKTHPSIAPHLEGGTCISYGARVLNEGGFHAIPKLTFPGGALIGCSAGFLNAVKIKGTHTAIKSGMLAAEAIVEEMGDGDSIAETGELPEDHIPQEVASYASKIESSWVHDELYEVRNCHQAFAKWGIGAGLAYTGLAAHLLKGKEPWTLDHTTPDSKTTKEAKDFEPIDYPSPDGKLTFDLLTNLQRSGTYHAEDQPAHLRIKPELAEFAESISIKDFSGPEQRFCPAAVYEYVEDAEEQKKKLVINAQNCVHCKCCSIKMPGEYIDWTVPEGGGGPQYQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL07</accession>
    <name>A0AAD2CL07_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000635">
        <property type="protein sequence ID" value="CAJ1937347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="435" mass="48619" checksum="846D65A38DF0B695" modified="2024-05-29" version="1">MTAAQTSTAGTSGGNDQPRRGAANNAGRNDNKKRKEIFKGDIEEMGGAVLQFPDERNRGSAAQYERFYMALKDYIGREVSVGAAKLWAKTYVKEMDPSWEPPVPIEPTTNKNDVKALLLYESEKAAYVKHIGATWPAAKLEIWSTIMAQCSPKLRAHLQQLPFYDKAESTHDCIALLENANVLCGGGNLLAFQPQARAEALLDLVQYKQLNGTLDDYYNDFKARYATFSSLGGDLTTKEDTWTTANGTKASTNQALLVCLFLANADRKRFGDCVTDLRNDASSKLVRYPETLADAYTMLGEYVRKHKKNSNNNNSDELNAYLEIDHSRPENEICLTSTKYEWLIDLAWILLDTASTVTIFCNALYLRGMRQARHPTTIHTSGGTITATLEGYLPFLRKWVAFHPDCLANIISFRDLLDAHHVTLNSRQSRSFTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPN5</accession>
    <name>A0AAD2CPN5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001057">
        <property type="protein sequence ID" value="CAJ1941660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPN5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000035">
        <property type="entry name" value="Fcf1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1941660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="196" mass="22464" checksum="DBBBC71ADFA75267" modified="2024-05-29" version="1">MGKAKKTRKFAVTKKIISPKDTRVKENLEKAKKKAADKMKKEEPRQIEQAVSSLFFQYNTQLGPPYHVLVDTNFINFSIRKKLDMIRAMMDCLLAKCVPCITDCVMGELEKLGGKYKIALRLAKDDRFERIPCDCKGCYADDCLTNMAKQWRCFIVATCDKELRGRIRKIPGVPCMYISGYKYTVERMPEAFGAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQI3</accession>
    <name>A0AAD2CQI3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000861">
        <property type="protein sequence ID" value="CAJ1939869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQI3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="317" mass="34882" checksum="41D232876E7007EB" modified="2024-05-29" version="1" fragment="single">LDVLSDSESSGDDDDDDSPPTFEWTTIIKKSLVASTPKPVEDKKKSLLMAPKSPEDDDASIDQLAQMDLTNDRPSPLFVMILPAKEDGCYFVVVRQRYLPLAMNVLDNLPSFLQFHLGELLFPNFIPVIKNWSATNLAYQNRKLYVEWVPSELRSRYPVEILEGTLHIDIHAKHVRDVDDGLSVIGYLDDWNESQAQLQTALQTIETITDEKNSLNRDLQSVCDELEAMKAAQETAAAMTELSKTVRPVPMLTVAVPTGPPGQTRVSTAMLLSPLVHGSAPPATAHETDGEDWEDQPNASSPMDTGRGGISTPTTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRH9</accession>
    <name>A0AAD2CRH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SPRY domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000702">
        <property type="protein sequence ID" value="CAJ1938322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11709">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035766">
        <property type="entry name" value="SPRYD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951">
        <property type="entry name" value="C13ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951:SF2">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20355" checksum="2A4A88B0FD6AA0C5" modified="2024-05-29" version="1">MKVKKLSISKNMTSPNVEIGDKGEISGDGLALAGVQIEQDAAYWEWHIKLPSKTHCDTIMFGVTSKKNRGFYEELEDKILGEEGVSSQHTGTNWMRKVEVENGDVVGVAVQQSDLPMVQFYLNAEPLHDRAVNRFRGTVYPAVCLPKSVSGRLKVHLVLEESNFKQRSPGERFGPVIVARSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRP7</accession>
    <name>A0AAD2CRP7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000957">
        <property type="protein sequence ID" value="CAJ1940769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRP7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1940769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="197" mass="23069" checksum="CC60D46C16BA038A" modified="2024-05-29" version="1">MNRIPDIDREIAMMDERFTVKLHRILEDAQAQGFSHVIQWDPGGRSFTIHQPDVFSKTIMKTYFRQTKYKSFQRQLNLYEFKRETRNGIRGVYSHPLFVQHDRFLCQQIKRKSQQTTPAAPNPPKRQRLDEVALPRRPPVMSLRHPFDTSAVEASRTAKAAADQIRYQKNEDDDDSIETIEGFVNDVDAGELFKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS66</accession>
    <name>A0AAD2CS66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS7683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001090">
        <property type="protein sequence ID" value="CAJ1941846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="9">
        <location>
            <begin position="1828"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1941846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2140" mass="236010" checksum="631757122892D0AB" modified="2024-05-29" version="1">MNEDAGRAADVPLVTLQANCMASLRHLELRDSRFGNYVELLSMDTNRKEQALMTQSENDELYQTLDGLLHRLILRISDNSKTSKTAKTSVFHVIEYLLCRYDIHLQPLLAETVLRLTIPFHEDPIFLRMIQLVDLSILPTWSFLRPYAAPGATVAREIISKQASIDVSLLSSLCLLAQRSAGLPCNAHHLSFTATVISECAAFQVTRLGGLTERTCHTLLQQTLGACRQSKNVALQNWGHVMASTIVETASLADESLNILVTSILKGIADSNKSTQLNGLLVAFSSISKRWKHFAQPLQEMQFFLGDENGMKISIFEEFLAVKNLAAQLGHLFCEGSIDQVSRWIACMLVVGARLLQENATTKVEKVRKLILDLINEPNLRILWETASNRYLESFAAVFVEILARKSEDALQADNDFEQAVFKPLNSIDSSAFENGIASALFRMKGPKRQRVLHRILTDKHDAGIKAGLASESLLSPLIDVEHGSDGNRIKLIQTIIGQHNGNEFTIHQSRKKAQALLDLLNHDTNNTVAIAAGIALVDFLRSQQLSNTACEIGEAALQAAYKWFDWQLSSSFKRSSVLEQVLRVLEAISLNLVSIDSASPLFCRIIECLGAFCSSSIEVVAQHSSGTLHRLLGTRGIDMTGLQKIHVLLVSDETILHIFRREVLVGRSLERCVRHHCVQSLLQGFLEMLRSCQNGEKRKVYTTEATEYCLWAATTFANELELSDRTLLQSCILSLGNHFASSHQQMQHFITGLASAEGIFFTKYLSPLIQNLCASLEKKNGSKIPGLNVLMDVAVFASQQANDTTVTNILSIAKTYIEGFEATLEEVQCAIATTLCFLTDMNVEIRREAVNLLKSAGSFLAKIQNKLTPCLIDLCAFVTENESDVSIGDATLLPWCLASVMSQSKQKKQLLEALLSSCANAGCSLANNECFATSGCFTAAVLLTAAELAGEEIFPLEKRWELAGSPILKHIQSHLMELEQIHTALEPLISATIRMLLGLKVINSTVDAGPKTTNVANSGARLSSGRNQSDPFRESDRGRFLIPYPKGMEIAILSILKIDAKSNTARMLQENLVVQVVRSQSWKSEIFAVLSSTTREKIAIGTLSGIIDGVDGFDQDIFLNLPLSTSEVMRMIESAHRTQVEISYLSEYAVFNKERLNRESPNNNLILALFGSLEASLSSGDTAVSTENDYSCEGILSAVLELLKSSSTAQLRTVTTEAKAQSWVAFLLHILVRNVAQETFQSPRVHKTFIALLDALCPSFPSVVVKQLIPAMNATIAESIDSNAPGFLIDCLVMIVPQFLRHAALAGLEPIDLFKAFVSHSIKIANGKKRTMLYQGFLKALSRMSVVGLSDPLPGAFVSTCLAMELHFEGKETIPPMSAPLCDLASMILNDSHIAIKTSSTIAMLAYGKEIIGKLLHGKETNKTEATVKVEDLIFISVNGTIETCERNDLIGDPKSLMLCNLLLQSVCKNTQTTSFQAFLHDLDSSDSKKLLPFWQDLIMVQAAGRNVVFDSEQGGSQKFWKILLKTTDEILCNLHSFIPVHIFLAFATSVIENGESDELRSIAVHSIGDRAILFHPHDAEATLFCETLPFLTEMLCCDGVSVFQQSLLVVIETVARKLCLGFDLRKSSSLEEELVTVINKSARLIKHELSCAEANYERIAPLSRETICIASLCASTCIRICGPRALKTLPILMKAYTDTLCMINGYLSNEGVQQRKKKEAKLMQASSTHSIIAVVETLPQFLAPFLKDIFDPLALPSKAFREQDDGLEIVDKLNTTLVSHTPTRLLLPALLEAIESNHLDVTSLLPVVSLLNRTISKSSRQDVVCHATRLLEVVTSTLDYPVQSDMQSQVLHAAHDLFLGFVLKLSEFQLRSLYLKLREWKGDLDIGRAVGSARRQAAFWSLSAALAKHLHTIYLPCLSLIFTDLISELEYEAMVLCDRLHAPGASEGKRLRLDQKKTQNLSLYDTTPVENILLCLQQSLRSDAHDGGRWIREGNSQKFERLLDPLSKLLQSACPPKASSISTYEKVVQGTNPQSGSVIACIVSLALAAGDEQLWKPLNHHVLQAASSATRVEVRRAGVKCLASLIQTIGEEYMIFIPECLPVLSELLEDTDPSITSLAQDCITLSEEFLGENLQDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU13</accession>
    <name>A0AAD2CU13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001033">
        <property type="protein sequence ID" value="CAJ1941531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU13"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="303" mass="34262" checksum="E2530EAE5C5B1216" modified="2024-05-29" version="1">MHRLRERAEKEEKRIKQIVGIANSAGRIRPNRSYFPGRPAPPRPGGRAFAGFHQPEFQGFQGFQDDCSFQAPEIETGGTFHTAIMPPPTLAAKQNVRVTDGQGRQLVVPTSDSKLYCPEAVVNMLSCMSIMEELGQQQEEENGWTMLSQAEEALQKASGKPYPIHCWGCKEEGHNFRDCPHKEDPQVLKRFYEKLDQWKQQKNEELNRNRNNNSHYRRGGYMTQAICDTVRAIEDPQTESGERTNLLVNLVKAVTAHTSTAAARKRPKRQSTQPALSFVTFGSFAAMEQAHQLNFSLNDILAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUH6</accession>
    <name>A0AAD2CUH6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000558">
        <property type="protein sequence ID" value="CAJ1936818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="509" mass="57047" checksum="CB73E8A4856B48DD" modified="2024-05-29" version="1">MSITARRMEQERQEARTRLAATNMGQEQPPPSVPTLVDRTRPVISTNPTHLPASTSQAILEEPPRPAFHQAAQADSSKGNEEEIHGISITSLGIDRAMMPEGIKNAKIKGSWDRASNMAALPGKCSPGGGDSESGGAGEEVMNQLLETFGSDSTKIALLDTGYCRKSRHGLGLITSSNKLHEACQKVLKKEEDTFKNQRFQFLHYLVRLGYSTEFVEDYVERGLMPRIIKETYVNFLALLNKIRHKDMGADEAWEDSEAYVILQVHSENLLDICTNSNSKKMLLLQNYIYLCDARKKDFCSNTITEKNIERVNKTNQKLQRELESLWAAKGRGGREPTKDKDKEGDSTLKKCSQCKSRTLQTALKLKHNKTVCPPGRACRLMGQGRGGTSCYCRLGQQGAPGWRYYQGSIRQLAQEILGRGRNWQPPEVPHMWYTLEQNSGGAAWSTLGTYPKGRRKAIYYFGDHHSEGTTERSPLWGQCTHHTSSQMKQSLIIQTASYNQHPPPPPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUN1</accession>
    <name>A0AAD2CUN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS7835</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41394">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MGTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41394:SF5">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042005433" description="SLC41A/MgtE integral membrane domain-containing protein" evidence="10">
        <location>
            <begin position="30"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="203"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1942214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="344" mass="37537" checksum="53D8386616822D0B" modified="2024-05-29" version="1">MTMISYSRRNSVLAATLLLLQHYSLVCQAWSPLKPLSINPLSIRHQSSNLFKRVLPRKITLPSFELSSSSTAEEDLDEMKSENSVLRDTIRQLEEENQNLKQRNRIVLESFEGESLFWDQDSATGMSSGITLSGDEISQDELWCDELEGDQCPVEPAISFKEALRDRALWLVGLLVMQSFSGIILGRNEALLANHPVIIYFLTMLVGAGGNAGNQASVRVIRGLALGTLNEKTRNQFLNREVKMAGALSVILSVAGFLRAILFKTPLPEAIAVTSALTLIVFSSVCLGAVLPIILEFIGVDPAHSSTSIQVIMDILGVILAVTVSRAVLDGPLGVFIMSKLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVA4</accession>
    <name>A0AAD2CVA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS5753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1937656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="60791" checksum="163F2FA30EE62D50" modified="2024-05-29" version="1">MSSSALDTTNNNNDGATAAAYSYMPTTTQQRVISSIQIPVSMLSLIGSSLIVYNIIRKNSSNSSKNSPHGRIMLALSVSSIISTLGWMLQPFLVPRTDVPDPWVYAVGNDASCVMLGAISQFSVISQPLYLAFLSLYFLLTVKFGVKQRDFEAKYERWIHASIVLIAVSTAMGGIALGLFRPNVISPGCWVNHDPQDEGCNGRWCREKTFALVFGAIPSLASLLVIFGSNLMVYVHVRTTVIEGQKKSMTSEMKLTDFQASLMSSSPAPLPPESTSRTFSDTQQQQVDECNVGTREEAVDARKKYTHSNASFSDISVLSGGDGKRSVLRSSNKQWKRVRKVGRQAFLYVGAYLLAFSWSFALHCCLIVLDFEHRQGSEDVTFPLVVLEAIFGGSLGFSLALIFFLPKIRQARRKYDCEPWWWVLQQVITGEAEKVERFSSISMASTIQGRRLSTSSRQRGDMPNKTKNSLTRGQASKVPPQQQVPVSISMSPILNRSESLSIDDMIEADMDTADTEELEHQEHITETHKNQNHESSSTSSSKSDEELGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXM3</accession>
    <name>A0AAD2CXM3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="449" mass="50933" checksum="CB86335C2794D7B9" modified="2024-05-29" version="1">MLEPNDLDLKGEFSDVLFITGLLCKGRSDEDVEQFLSMSEVNFVEAEQQIDAPGGGKLWVRCESIRQAKKVQAIFHQQSFKGAVIMCRYELGFDPETGKRRVSRNSIHTTCIRRVQQRRGENNNRNKGVDTHTVPANYSYRSLSIGEMEYPFPSGVYLARLISLVQKWPNRTDDPLIELVSNNYIPPNAKKKKKNQNPSSVFGNRYAKEITESMAMVDAVERAMKLCLGRSTSSFRLSASTNRNNNVCVRVYCVGDGKYPVSAAAMALNYPYPGWEFISIDPLLEPLDIDNATNDPEDNHHHNYDRHRHRLVQFTGLSQDYVLPDLPAAFTTSSPDESSSSEIETEYVDVVVACHSHAPLQEFWDRILERIHSRYGSSCRAIAITMACCANYSDITQPPSLVFDDYEVYSPKRQIRIYNNDNLFCPQIVKEGRKESIKSNTGDRQASVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYL8</accession>
    <name>A0AAD2CYL8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001546">
        <property type="protein sequence ID" value="CAJ1945848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYL8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="368" mass="42592" checksum="EC0B1AEF6DCB2659" modified="2024-05-29" version="1">MTSSHWICRLTLADGRSVDCYIKAAEAGYRHFRLPQRLTQLAEDILVQDGYLTSNQQARFNTIHRQGNEIRRKAERNYRKLSMGKVHWSPQMQQKWDRLHLYQLLILGHKQVRTSSRKVRRLLKKIGLTDAWKLSEADLQAKWYLEHQAYKEAKRKRAHQWRLEYLEIRLAAVRRTKKGNIKARIRRTRVQQMAQKEETRRQRKAQGKGFSGGLQQIKVAQVAQDGTSHWVTCQSKCIVEEGCMQENRLQYDQTRYPYPTPPMTAPLYSDFNGPNAKRNSQALLRGLYDAETADPYLMSFLDHCRRATGSGPGGHVSFWRKMGEHKGSEPHGLHNGHFKVGVASNLLACCDTLFCSIPFATGFVPVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCC0</accession>
    <name>A0AAD2FCC0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1930993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1930993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="211" mass="22820" checksum="2FFBE1E20C2A9460" modified="2024-05-29" version="1">MSTVSSTNQEFFPILANIYPWASTDGTGPQFSSIDQTMGFNEMVAAAMDTASFGSGGFEIHHLLKARQPTTAVRLELGRVDGFRSVQLAWLREGCNNGGDFDLTDAYDHEVVCLPQYSSIFVAAAEVGGGEACLELSTTASAESLNTAVETGRYQNSCSIPPINAMVELPSGVTLWEVQVGRTERNGIFNGLSLKENYFARVWLTVKPSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDD9</accession>
    <name>A0AAD2FDD9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000262">
        <property type="protein sequence ID" value="CAJ1933335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDD9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="129" mass="14504" checksum="00DACA7AA9E18B65" modified="2024-05-29" version="1">MVKLPSQINPTASNKLLIVNLKFDERLQPTPLQEFRKKSPPQIPAKSVLNVLRDGPLSAKLSHAVGSAKNDELLHFRYASFGLFGAVYEAWLNHWALRTTPEDWWFPVALKIAKAVDKQPSMGTVLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF24</accession>
    <name>A0AAD2FF24_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="529" mass="59851" checksum="6420558ED7E19DB9" modified="2024-05-29" version="1">MSKSRSHRKRHVPPGPVGIWFRTQQQQLHSKNQGSVTTVNAEQRSSKGDSSDNASHSDKSNNHKGGRDSSFSPVWSNVQEDLKLNTPYLSSWNGDPKQKYDELRPHLPPDFILLREVLRGDHDFAIPPGFHLLLLVNSIESHNLHSICTVELYDETGLSVRAWVEPRYVQEQMRKQQEASTIRTGVVWMLQEIGMMVQMNEDDEKLERILLIGGKHITKVWTPEDAKDMDFLQHMERKKAISQHIFEIDNDVDSVHDGLHEEDVHETGDSDQATKDNGIAGGTCDQRFFFFSHATKKGEEKNLKTKNNSLPLIGTEQSTAKSSSQDVSCRPSEQNALVDTTTNCPSVPFLEKEETEAQSFNEQKSGTTLTDKNNRHNKRHDEKLHQHAKNRRKRSKPSLQSPTQAEGGPHRISNSLASCLWDNVQTDEVLELFDDNEDDSDTFANNLAHPQSIQAKNISLSSEGSRHKEEERRSSTTRPQPQKSDEMVPQSRFGLCSSLSQDQNENDPSFSLFEVSHLAGLDLSAFDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFJ4</accession>
    <name>A0AAD2FFJ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1914985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF261">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1914985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="370" mass="40555" checksum="B1A8924FAADC68A5" modified="2024-05-29" version="1">MVTIPSSIGPNNVGIVGGGLAGMATAFQLIKKKPSINVTIIDKALPGTGGASSVAGGLLHPLTPRGKIAAFGIQGVDSSKTLIETASEFEKGVVLRDEIYRVAVNNKHRSVLKAAASSHPQFCEWLEANELEWDTSSSSVLGALRIHGSGCKVIHVPSYLNGLWLACESRGTGDRVWALEEDCADWKERLSEFDAVVLSAGAGMFQDAVVKQELPVQLVRGQSIELHLRNRQFEQVRLCGKYATPLPDKGKVNIGATQEFKDEPLDCASVKDELQMRSYDFLSDLWDDGDVHKVTEGFRVQSDRGPRGRLPIIGSFDSELHDNAWIFTGLSSRGLLYHSLFGDMLTDMMFDSDENYQLVDAESLNWWVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG93</accession>
    <name>A0AAD2FG93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS1430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000036">
        <property type="protein sequence ID" value="CAJ1928265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="65"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1928265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="284" mass="32594" checksum="7A433E84CBA50E96" modified="2024-05-29" version="1">MSGQRPLATLDVSQVEGTWQGSLVNAILWMDDTLGADQWTTRQIAVVSILSIGVVQFTIGDWKKVKWFSFWHAVLSGYGSLICVLLNYFAAYRMTGYTEPMGSVLCQGPLTSLHRIVPAITMGFGMFDIMEGFANGIDFMLHGLATSFIMGYFTEYDIGEIVTPMLLMEISTPFLTLTRFELFNDKAITINMGLFVLSFFFYRCLVVPYIMFEVFTTLMKHRNDPASQECLPWHLPHVVFTFSVFFCTLNFYWMYKIVKKVQRKLSGEEKLKDKNDVSNHRKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGQ3</accession>
    <name>A0AAD2FGQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="225" mass="25573" checksum="CFEACA6B57012484" modified="2024-05-29" version="1">MKSDGSSIVVVFGRPGAGKTTISSMAIEAFENDQQTMMMMMMRSRKNFVLTGLDLDVCVPQWMKDNFSKGMYPTLKQRNEFAFECCKYVREKLAGGEADPAKPINNNATIISFSFVNDDLREIFRSNFPEATWVLVDTSEEEATRRIQSRQDHFYTGEASQSNTDNDEDRTISREQDHDPTNQDNSDWKFAAVTFEHEILDGKEAVEKNALKLIEIIKKLPMASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH34</accession>
    <name>A0AAD2FH34_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000724">
        <property type="protein sequence ID" value="CAJ1938495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="121" mass="13440" checksum="F06541BD18C7E348" modified="2024-05-29" version="1">MADFTPALTIKECLARFDDLPQVGNPPTYKEVNASDIANQRNTAKFPSPNGGGQLCHVGLTMTAPDYALISPSYAWVNPSNFEDRHLIVTGDVLTADMLISFFKQVDMEFLRCRDENGQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHB1</accession>
    <name>A0AAD2FHB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000174">
        <property type="protein sequence ID" value="CAJ1931714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="198" mass="21808" checksum="5C34BB7B540EF268" modified="2024-05-29" version="1">MTTALKRGVTINPTVEVAEILSIYDYTPNEIAAAWYDEDDMDKITRQCFKVLQRMEECGGTKNGQKYCTRGLEGHTTLGSISKKKTRTASFAAVLNEQARQWNKNEQADIRAISDAYRKTSSSSQMWAQVSGIQDRQAADACHNEDEEENDDIDATTTAVSIKPAEESVFKSPVSQKRMASGLESAAVSMIQQGARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHH8</accession>
    <name>A0AAD2FHH8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000990">
        <property type="protein sequence ID" value="CAJ1940985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHH8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="297" mass="32788" checksum="BF90B8DEDBD0AD75" modified="2024-05-29" version="1">MGKRKTGKGPRAQRVSENDSYHAPVSLVQKERGKVDKICPFDASAFLGLLDDDDSDEIADDDEDNKTPHSQKANWDSYYISSYPVPQEQAKMVQSCPFSAAFLGFPDDARGPINTVFDDDGGMATEKASSTSALSTPMVVLQDAEEDIPFQKHDQMAQQLFSFFAFGGKNGIADRHEAPLWKHGSPATPCKVSRLAETAGPWVHVALLTIIICSANWMPSPLPTPCNNPTLGKDLLQSNCYRFLHPPVDWQMPQFDFALWMFKCWHSSLLHPGNSPLICGFTMPGHNLLSLTLFASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHL6</accession>
    <name>A0AAD2FHL6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHL6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="224" mass="24778" checksum="4C0425D02D1849D7" modified="2024-05-29" version="1">MRKLGKISECQSSSLSTNPVHQFLPPGTTWPTYTKYWALPRDEDNDSQNEALQDSTSIENTKLQKNTKIDEQTQNMLVSLLRNTDLLEVRLDATLCAIFGMARFLLYDLTLPRKKIPGMEIVDVVAVLNTFSSAAVLAILWSIAGVAIGLFDTRTNSKDDPTLLIQLIGTTAFSVPLWVFVEKVCHWPISAGLESASLVYAMLLSSLGVLGTMLIARTLSRFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHT3</accession>
    <name>A0AAD2FHT3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHT3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08640">
        <property type="entry name" value="DNA_pol_A_plastid_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF27">
        <property type="entry name" value="DNA POLYMERASE NU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="462"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="509"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1940128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="989" mass="111214" checksum="8A60391152917631" modified="2024-05-29" version="1">MKATVVDESSTSSSTISNDGPLHEQTNDEFLEFEPELFEGLTSRPKPGGNWNPRDPVAWSKNFGRRSPEYEERLKSIIQLKEGDEGYFDHSEMKMPKVTMVRTKEQAKIVMEKLMNADRSILHAADTEVMDISLKEVGPIGNGYVTCASVYSGPDFDYGLGAEPGSTLWIDNLDDACGILQEFKEWFEDPTIYKVFHNYGFDRHVLWNEGIDCQGFGGDTMHMARLQDTSRAKGQGEGQGLGYSLEALTSTILGMRKRPMKEIFGVPRLRKDGTPGSLIDVPAIEVLQRDPRFRKNFILYSCYDAEGTWRLHQELVRRLQEMSWLANGKNLYDYYWENMREFGKVLTDMERRGMRVDAKDYLASVEVQARKDRVEHSRKFREWAATKIGPDGLAMNPASSTQLGAFLFGGALNEKTEEPTEVERVFKVKREEIPEDALAAYEKRDEDNKAGKSQVEVESDELDQMTATQLKALCKEQGLKVSGKKDELKDRLRVHFLSGKVDESKMDEFDEMSDDELRLSLAARDLETAGIREDLLTRLREDIMFVQELETVIPPDAANGYRTISEALAAAAKDGGTVGDILAAIDEKNSAGPKALDVKITSLRMQPEKYTAGGAPSVTADVLRKLAGDPFEDPPRYGTAYDFFGGGKEGHEACEALFSLCAIGSIDTMIANFLTSLQSLADHDSRVHCSLNLNTETGRLSSRRPNLQNQPALEKDKYKIRQAFQSSAGNGLIVADYGQLELRLLASMTRCKSMIDAFESGGDFHSRTALDMFDYVREKVDAGEVLLEWDYSKGSPPKPLLKDEYASERRKAKTLNFSIAYGKTSHGLSQDWGVSTTEAQEMLDKWYDARPEVRNWQKNTKAYARKFGITRTLMGRYRQLPEATGRNRRFVGHAERASINTPIQGGAADVAMMAMNKINNSEILRRLGWILLMQIHDEVILEGPEETAEEAFKEVIQCMEAPWVPGLEKTAVPLLVDGSYTHKNWYEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIC7</accession>
    <name>A0AAD2FIC7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000331">
        <property type="protein sequence ID" value="CAJ1934080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIC7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="359" mass="40668" checksum="8762677F8A4040FA" modified="2024-05-29" version="1" fragment="single">SRPFRQAPTLALKRWHIFHLLPLQREGYSGEHLPSNGLTLLEAQQFGKFLFLIMAMIGSEEKLNSDYDDSKFSSSIFGTVLTFLCRVPQNLNLQRVWTEHQRSCTQQWMDDLIATFELVAKMVANQRSGSSFCTFGMRDAQLIHDQANHFVVVPTKTGDNDFAQVPLSYVTDMKRLYTHCFDKWAPGIVDVHDPKWATSSAHPAYFSHLVHPPQERQAPPDAGTGPIQVVKPLFKLLAPVPPGKNPFEVFMPKLQAKTSPLIMNPNGKTKHPIYFRSAFEGSCTCDATGICRSCYPPLSAGVGQERMHVDFNDPCWQRDNYREEQWAPVVKFVKHYHGLGLLGPTQWLKDTTPNTPWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJG2</accession>
    <name>A0AAD2FJG2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000480">
        <property type="protein sequence ID" value="CAJ1935507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJG2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17736" checksum="56735E193396DA6C" modified="2024-05-29" version="1">MKRMINKSFAVHPDFKSHTGGTLSFGGGAAQVMSKKQKLNSRSSTEAELIAVDDVVTMILWTKLFMEWQGYPIEKNILYQDNKSMILLEENGRKSAGKRSQAINIRYFFITDQVEKGNVKIKYCPTDNMIADFMTKPLQGEKFRKFRDLILGSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJX9</accession>
    <name>A0AAD2FJX9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10936</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12937</name>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9332</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001722">
        <property type="protein sequence ID" value="CAJ1947004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJX9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="139" mass="15388" checksum="D8CEFE15B04CD755" modified="2024-05-29" version="1">MTNHSNSNNSMDLGTEKRGAEIAINKGKYKGKFGWVDLSRGENGFSSTRKSVYVIYCEDGTTVAAPNQIRAKSIDYQNWHSKATVGSNFLVRNPKVGQKVSELCDLMRAVNYASNEDKAEMMGYVLQVIDAKMRAPKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKK4</accession>
    <name>A0AAD2FKK4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001513">
        <property type="protein sequence ID" value="CAJ1945789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="403" mass="43484" checksum="FB28D8A6DA5ED22F" modified="2024-05-29" version="1">MAELQGMLAQLIAQLDRQNTAAEQANAAAAIAAAATVAPTAATVAPTAATGSSMADPLATPRDGTVDKMPAFLHDLKTALKVHKMDTAGTSSIIFFGGKNLLDDYASIPLVDITAAATSRTDARAKQNSKALFAKLLGSTTGALQDKILKTNGNLPNHEDGPTLFKEMIDTTAVSSVLVSMTALAELDPGDFEYKMPSVNIELRPRSTKTPPWVALAVTWNGRERWSNESNRSCKLQENGNLGDGILNIRRSITTGGLAGSWTTGPWIDLLVDHWSTARRARGPLVHGSISSWTTGPRLDVLVDQWTIQSHCPIPIAAAGICSQLARRLAGMPGKNNDNPNGRYYQSMLYITLKRLSMTNKRRSDGFAHCFLDQMVESGANKLPSNLWPCQIRHLLVDQPKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLS3</accession>
    <name>A0AAD2FLS3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS8049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLS3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1942642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="756" mass="85728" checksum="D38342894A45EE24" modified="2024-05-29" version="1">MNPRTPSPRKRVFRTAGGRDAAGLPPPPLFQVPEGQSNFDETTLNYNDLRLHRKGPSKPSSRYPKGWNESVESWEERYVRSPTSFPHSPSAFYSPAPSMMTATTAPMTATPTEVDISVYSSTTQNNPYFIPITTLSPDAVPYCQPMSPPPAYLSTLHANSRHGSRASTPTSHHNSTSNYEYNNNSNNSNNSNNANANPPGFSTPRRSPTKQRRAPNSASSVGSAMDDPNRKQRIKTELCMHHRRGNDCPFGEKCTYAHGEEELQLTRLMDMQRAGLIEDAETYRTKPCWTYVATGSCPFGRRCGSIHDPRTTGTVSSWLPHTETQGNSMSTDINVDGLHQKRLHSIQYGNPFGDQFSIELDDFADLYKLICNNTSSNKRRRNNLSEIHKLSMALQMRGEAGWMYKYRPQHFIRGTLCMVLQKRAFRLEKSGTALPIPLNKYKAEHSGHILVRELAFGPDSDPSVRGVALYFNIPKEDVSECTPQQAKRYRWKKSSGARENNRDKLSIFDKQECFVMIRPFEKDPFDLATRILQHRFDTVKAERLSALKQRFAVMKKLTKEKEDLRDTFHIHKKDWIKWSWPVCFGRQNVDEDTCVPSVEAEYIPIVDSGAIMDDDAGSEAIKGSAIQPLWESFVAQVNKFEEQVGEIDDAPRVKKNLFSSLDDLAPRTDGTSRLVIFKRLASGYQVCQNRSLPHIKSATKDAVENQILGRQSERCWKALLLKKHDNEFAKNGNEWEVVQGHFQKSRSNKVLKIIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMB7</accession>
    <name>A0AAD2FMB7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001373">
        <property type="protein sequence ID" value="CAJ1945354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="297" mass="31857" checksum="88E3D98548208E75" modified="2024-05-29" version="1" fragment="single">RIERFMKKSADAEYDFLDFWEANQKFFAMKQGTTENLMHFKERFLTTTRIPTVFFVMKRCSAGFRDFIARCTIGQSTDRKCLGARRPLAAQYSINSGSVNDGVSTPRTDAACAAWRKTTYTSPAALPPGPRPSGSSYSKNSKIGSSPPPLLHPSPNSLGPFFAPSAPLTTSLKLRLRGTAYTECLLPPSPKSVRLNSALAPNVSSKAFSSTAGPTPSNNSLAVVADPVTAGLPIYLDSSSLSVKACGSIVMMSFILTTTSSTNSTRLLSIDASTKSLTWVLATYLGTFALPSVDPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMN9</accession>
    <name>A0AAD2FMN9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMN9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="243" mass="27462" checksum="6C69168448EBFE0B" modified="2024-05-29" version="1">MFSSNTQSSSQPEFKSHAVAQSYNNKAASCIDDGRYEHAIRYLAKAFQLSSHSSDGTQSPPTNFGGHSLQACLRYSRSSFSSQDLEKQLSSDKKDSSEGFIHRVPLRISTHFIDMPMGSLFSFILTYNMALAHHLSAMGETKENQRRRKLQKALKLYELSYRWHVQEEMNCLAFSMIIANNLSEIHRVANNERKRQMCLQNLLSTMMYVHMVDYNRGGEVGEMDGFVQNTSPLILKGQCAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN66</accession>
    <name>A0AAD2FN66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001723">
        <property type="protein sequence ID" value="CAJ1947018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN66"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26292" checksum="2842BDA7118EE36E" modified="2024-05-29" version="1">MYLSTNTRPDITFAVSQVARFSSEPKQSHATAVKTILCYLKRTCTKGMIIKPTGKLNLDLFVDADFCGLYNTEPHTNPNSVRSRTGFIVKLSNCPLIWRSQLQTSITCSTLEAEYNALSSALKTLIPLKHLLIEATNHVELDNGIRATIWASAFENNQGAYFLVTKKRITSRTRWYLNKWHWFWQHVTKDGVGPETVAIHELDTSLQDADYLTKAQSCEPFESNRFQVQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNJ4</accession>
    <name>A0AAD2FNJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001726">
        <property type="protein sequence ID" value="CAJ1947438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="158" mass="18034" checksum="CC47DE42DE172574" modified="2024-05-29" version="1">MGKSINAKASSAMTKKLGVSKMKTTSVAKKSVKKRVEIDLQQPKDRDPIDSKMVSATQTEEKQATDNNEAQRMADEIEAKRIAEREALRSGHYDNIVPNLSEWWMKNLYSGDAVDEALERHDRIHTGNALFMAWEERFSAAWNQPCLRYDDPLYDSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR37</accession>
    <name>A0AAD2FR37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001762">
        <property type="protein sequence ID" value="CAJ1950326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="434" mass="49486" checksum="684A07BAFBE49215" modified="2024-05-29" version="1">MVQVLETEIWDEANQTWKARGERWTTAEGQVSAPPSDVKAPEGFEFEGEWKIVVSSGDSMGWEYEFQYLRPPKRKRTWLRSLKQSEKSSKKSVSKAVDRCKTMKRSDKSVSEAIDRTTAIDGAKGSIDGAKGNFARGLSLIRDDFNFKGFGLSIFKSLIFPESLGLSLRLPLSNNFDTWDRHPELPTISTSVSLMFPWTIAVFCNSSVRVEWLKWAVKRTLQFIPRLIIHCVYEVFLPSLWAIAAAMLSLTSARLPPIPKAPTILIAKPRYNPEISERVGCSLSYRWSRDRGFQWRVGYWHSYLPTLVACRKLLQMKSPADWWQKHFGSVGLSTSYPIPVSPGFSCSAQLSLSGLYFERKKEVRPSQSSRTVHNAIAKNTTDYCLFIYMRNENLITKSKEVTKLEPLEDLNYSFQPLSHSHGEYIIWNGEAGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSP6</accession>
    <name>A0AAD2FSP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="437" mass="49581" checksum="DB3044BB7AD29936" modified="2024-05-29" version="1">MPPSTAYNFKWQIGDDSSKVLDILQLSPTNDVSFGRFVLKEPPPEDELLLRNILQVFQHCSQHDIVWDWLDVTMESVGMMSFHFLRPLLFAANSMGIVRRVAIQGDATPINAGEPLPTHEFFLAGSLLNPRLEVLEIVANREGGLVPMGDYRALCELLQTTKSLRRLKLDRVTNFEVTLLCQGLQENKTLRKLSLSFVQCDVPDASIANVIQSLNDHPELRYLTITSSGQFGPLSSTALKMLLSSKPCKLKSLSLQGFEFFELDTTSGTLNTEDLLEGIQANRSLKNVLIGDALDGDMFFSKFFQLLGECPWLETLHLWEPNITNQDLESVLSEQVQRLERSVVIGLGFPVLDTLEKTLTQVLTKHQEIRMEHEGFLGNPSFVHLCQWNWYGRYLMDKPDFPLSMWPVVLKKANQKPNVIYEFLKGPAFAARQPYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVE6</accession>
    <name>A0AAD2FVE6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVE6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="180" mass="19813" checksum="F04EF1B268ACD0EB" modified="2024-05-29" version="1">MPEKHGKSSEVYKELLHDFMNFKQTGWKPFGPNIGGVEHMKSKTMYEKKMASRHAFRSLAKKVAADAVGLLPSSFIEDEGAQEDSDDDDDDDEGENKAARSSSANAASTSRKTSSSKPIDLTCQAAKEDVDGRILGFEVGQMRQHYLLQYPTGNKLGVVCCLDGDVEDRTSNQFKLSNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVZ0</accession>
    <name>A0AAD2FVZ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="318" mass="36227" checksum="68D0D6D49CECE1F0" modified="2024-05-29" version="1">MGTSTTLSSKTKPNFKKLKSKEKSFASRYGFAKKVNSSEMTEKHYTKPRANYESKDAASCIFKNEDLVIEIMKFLGVRSMVAFGSCTTGLRDGLEREVKRRKKVFATCNSRVKALLEDANPCSSKVLSARRIYSAAEQMVDDELRFLEMPRRRFRGLSRYPFKDEAQQFMVLKAGTDEPPVFQMLPVSFYFPLSGGTTFQPSTQELQLAMERAMNIVGLQDCTYVIFGQHVPYGDDPNHPFRKFEHSGADFFRNLMTIAANCLQCDIRALESFRIVARKLALSCPRSQDCLHFVLHSADLKVKDDRCQRVHVDISRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW17</accession>
    <name>A0AAD2FW17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NIF system FeS cluster assembly NifU C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000003">
        <property type="entry name" value="NifU-like protein 3, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF25">
        <property type="entry name" value="NIFU-LIKE PROTEIN 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042098277" description="NIF system FeS cluster assembly NifU C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="NIF system FeS cluster assembly NifU C-terminal" evidence="4">
        <location>
            <begin position="274"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1954510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="421" mass="45851" checksum="C43E79E0E13A7767" modified="2024-05-29" version="1">MSFNRKQKFALSSLLLVACCGPRASAFTAVSTPPPQRQQQQQCQQQTLTQLWATQEEDAAPGLKAPVLNGKRVLPFKVLMAGLKGAKVAGTYAVLNKDYKRGSEGWEHCQHVGVSVDLASTLQEHMDEYADKMAHVRALTFVVPSQGAMEEIANQWKVQAMEAGGSVHFDPILADLAKKLSLGLEDEDDDDDDDWDEEDDEIFSEMQMAAAAMSRASDVMGDSSAATEETPAASAESEDVISPFDANKKETKPAKSTKEEKTEAGTLVFSKETVDKVLEEVRPYLISDGGNVSVQSVDEATKNVYLKLEGACGSCPSSTVTMKMGIERVLKENFADLGEIIQVEDEGDAKPTELTYQVVEEEVNRIKGAIQAMGGVVNILNVDPIGVVEIEFRGANKVRQGLELALLDIDFVKHVKFVSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXD0</accession>
    <name>A0AAD2FXD0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001886">
        <property type="protein sequence ID" value="CAJ1955434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="167" mass="18088" checksum="A7894D5C08E1A9FC" modified="2024-05-29" version="1">MSPKCPDRLLPKIQWKNQDQYVNYGKKLNLNQIGATVPPTVPAIVPGASASTSGASSGSSGAQVRQGFDATQAQTPQAVKTGYFDTSNVFHNAIKGKDENGNNVYLIPCPAGTTNVKLQADWHYASEDEDLPDLATEADRGLQFIQNRRKQKGMGEEVWAISQHNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYA2</accession>
    <name>A0AAD2FYA2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001917">
        <property type="protein sequence ID" value="CAJ1956597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYA2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="144" mass="16106" checksum="60901ADE0CF299F9" modified="2024-05-29" version="1">MIPSDTPPLVDIAIGDWHHEAIQVRQAASTFLYNYALLKNKHNHDMADDAVVSVLCSAMENLTEEKDPTTCLWQLVLCGRLVFPDRINVNEVAKELIQDLGFVGILQELTTVDLEEGTTTSHGDTIRCNQLALELIGKFQDETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZK1</accession>
    <name>A0AAD2FZK1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="299" mass="33131" checksum="05A17B70E73E7E3D" modified="2024-05-29" version="1">MSAINNSIESTWHTPSESDVELSIPMVEASPIGDNQTVSPSPPTAKVRVKVTAPLALPPGFIIQILYQEKGRRGIATKIWKKAVVKVPVDCNGVEKGQVFEAETQPFDTVKQIRGDWDRSKVDFDVCCNSVTTDTEFCLLSWFCSPVAWACLFEQLVDLKKENFGLSIYRPRFVAKSIGLVSLLFVVLSLVSKASGTATTASSDTDEDSRVTTSPVYGMVLVGFTSPLSFVFLVFGMFVRSKIREYYSIRGNCIEDFLAVMFCSTCSVLQTYHHMKKAHEHPLVGHLNEPLTVEAEKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G001</accession>
    <name>A0AAD2G001_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS17341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G001"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="93"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1958768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="357" mass="39530" checksum="7380762315ED0BD8" modified="2024-05-29" version="1">MNAFSSQARQRIKEFNTGRKLINLRKASTAFDSKEVYAKAEIHEREPVRQYPLSGAMKTVPGNIARPPYADTGELPYSLFSNQILLHDAASVEKMSRAARLARQVLDFTCTLAKPGVTTDEIDTAVHEEIIRQGAYPSPLNYHGFPKSLCSSINEVICHGIPDGRPLQFGDIVSFDVSCFIGGVHGDNCATVIVGDEQEKDEIGVDWRGVPYLSTFDKPEDEEMMRSGRRLVHAARESLYAAIEECGPGKCLTSVGGAIQEVSDSYGYSTVTKYRGHGISSEFHTAPYVKHYRNNDTLELQPGMIFTIEPMIVEDAGDCFEWDDQWTVATTDGGMAAQFEHTVHITRDGVEILTLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G006</accession>
    <name>A0AAD2G006_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G006"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="270" mass="31351" checksum="B96C6B36B8D9E490" modified="2024-05-29" version="1">MAFIMRQRRESLLMDKEDDMTASTHRDSLTSDSTSRSGSWSEEDESETSSPLVERINNRPLHHTFTSISSNNQFPKVTFSPSRKTTTMLQKNKLISESDYDLKNSRDVMAGSVSAVVNFLRMAGIPKASMDELDENLNKGHYFDVLCRVQQYVQCIVSESNDEKDAKIHLAVTAWVSLCRLKSLEYKEAYKRTNKLKMEMSSADAKKWKRLQIEMKEALKEQVDLAEQCTSCQKKFYLVQRWEKQHLQTMKRNTIMEPEGYQPLRCLIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G196</accession>
    <name>A0AAD2G196_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS17966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I13 (potato type I serine protease inhibitor) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G196"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000864">
        <property type="entry name" value="Prot_inh_pot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036354">
        <property type="entry name" value="Prot_inh_pot1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF30">
        <property type="entry name" value="OS06G0587000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00280">
        <property type="entry name" value="potato_inhibit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54654">
        <property type="entry name" value="CI-2 family of serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1959545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1064" mass="115875" checksum="3B6D0651DDCA27D8" modified="2024-05-29" version="1">MAKKKEKSKDDRDEEERMKRIMMAATGYETVEEARQKPSGGVTRDGKAVISAKEFLEDMEDEVNQDVAKSGGRDIVAPNEKDDMKLNSVLIGGPAPKPPERRKVLHSQLASTLHHSHTKSSGVDQSMNLMDPSLARKGHPAGKGKTSLTTRLFGDSGFSSMHDADPSADSEEFILGKRHMVRYYNFICFLVVCILFMVGGTLLTLTIMSKQAPEPIDQTAPDGSKDVADFGTPIASPVAAPVSAPVTAPIVAPTPSDTASLGRFEAIMTRLVDTGFAEESKLRNAVTAQYKALDWLVSHDPAALDPSSKALLTRYVLAVLFYSTSGREPKSTDPIRTNWKQHTLWLTGDSCCGWYGIKCVDANDYFTTEGNGKISQINLPENKLKGTLPSELSALSGLISLNLKSNSLKGAIPTEFKFPAMKDIHLDYNHLNGTIGLQLEFMTELRTLSMPYNELTGSLPATIGFANKLRYIKLGGNRLTGSFPASIANLTKLETIHVSRNRLSGSIPDEFFEMKRLVNVSMSQNLFEGKLSPKLSQLSHLHELHLTGNDFSGTVPDAFDSMILLATLHLGENRLSGEVPTSLGSRHRLEKLDLTANDFVGTMPQEICDLQQTGKLYHLGADCVTGDTTALDVSSFNDNRRHRNRRLVKISRPPKDELYNDDPDAGKPRVRAGTSRLGGSFVEEDEDSEEDADIEDTDEEVIAAGDFVYLEEDGTVEDQDGNVIEGVDLEDADIEDADEEVIAAGDFVYLEEDGTVEDQDGNVIEGVDLEDADIEDADIEEVIAAGDFVYLEEDGTVEDQNGNVIEGVDLEDADIEDADAGLDADLDADEEVIGEGDFVFLDEDGHMEDKDGNVIEGIALEDVEDLDADEEEEITLKNNRIATLGESDDDHEDGIIHFTQPILNKDENADGDAKGYKIAYASQEVIKMDPPAGMEFNGIECPCCTFCLAAASSPEEPIDLPGGDESSLPEDEEILSASASFANDEDPGGSSECVDAINEGTASSEYPGLVGMNGQEAKKCLQMNTDKTVLLVRPGVRRHFAYQNSRIIIYLDRNGDVKKTPIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1W4</accession>
    <name>A0AAD2G1W4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS16712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001945">
        <property type="protein sequence ID" value="CAJ1957432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1W4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-SPECIFIC PROTEASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="490"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1957432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="776" mass="88848" checksum="14BA423CB3607176" modified="2024-05-29" version="1">MFSQASWELSQDISTKNNGTSVPLTQDSQLSLDPTSLTLTPMLSQLSQMSETSATPNNSQPIALQKDEPADPSTAAHSILEMSQTTFDAILPSTTCEAPLARPPHIQTDTLENKLKKLEEQRTSLLQCYYFHPHLLRTTTVSKLHFTKEHFGNDLVMLAFGIALSLRANTHSFFCNFQTGIRIRNNLRRKNAASLDTEVEISVQLKDEVNFFSMLAFEIGKKNGKRLQLGPENLKKRFLQHLEMVYVLYHLIQALLRHVLPPEAINPNDCLWFLGQLMVSCRTENECFESILKVALATQTIQQSPLLENLRTLWGKRTSSIFLEEIQSLLSSLFDNHTVADLHYCLEDSWGLLERAGLRTSILVQQCRVLNIVRQQAVNVNPGHYFTITVVAKALNLCLKHPSTQGRLLPALHLFQTHTQERKKRRSNFSRKQRSLLSCKRPVEPPQPCLLDTHSILEQRLDSTLCCLLQFQQVLPIVHPFRQCTPTAPIQLELESLSCLKVTTDHEKADFFRLWQVSRDIVVTPPTADNKIYSESVKRLKDDWLRDDLINAFFKKLCCRVRRGYNPGVTHNLCWFFTSYFFTRVMNLAVGFGFGDGSSNPDSGIDKSGDPFNKYQYANVEKWAKRLLPTGNLFLLDTLAIPVNFRGIHWMLCVVYIQHQKICIYDSLLSHKYDSYLVRSVVFQYILDEYQSVHGQPMSSADINKWRFANKVLNAPQQRNTRDCGVLTVLFGEHLEHGMPLDILQEELKDECQYKAIITRCRLRMATMVLKNQDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G207</accession>
    <name>A0AAD2G207_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1960016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G207"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="366" mass="41340" checksum="D3756C740B404D13" modified="2024-05-29" version="1">MEPGLKTIGVYAFCECFSLSRVSIPPTVVSIGGNAFESCRSIHDVVFVVGSLRSIGELAFAYSSRIQSVWIPPSVRYVGDEAFYDNEWLISVEIPRDSRTTFGWNVFSRSCQLANIALPPSTTQDELLDQCTVLNDAYGSANVMQGIKSRFRGYPVHEACYYAASVESDEMLVRALLIQDENNTYLENLIDPLGMTPFHVLMSTSKKRPDLLKLLLDYYPSNVLGLTCPSDDTALYYLTQNWTTDASIMLRMALQKWMVQDMASWGLPQWRSNMHELVESVFNVPRKMELHAALFGTLSKACDQMECYELMETTSLLELWLWKMKMQSTRNGVKRMAVDRASSRARCGATFIIPTVVDHLLGPDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2I4</accession>
    <name>A0AAD2G2I4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2I4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="249" mass="27913" checksum="B7089899B19FCF50" modified="2024-05-29" version="1">MSSSSTPVSFDALLDFHQKEESLSPYFPTTVEEKEADLKIVEKVLETSDLRGFGILIHREHGLVMLQCSKPKKGKPVPHFQIPGGHVDKFEIEEQQKKQPSNPWAPIYEAAKRGCVREIWEETGMDLRESLDRVRPLWLGAIKTNKGMRNEHKDRIFFVLEVSDSDFLTKAPEASVSHGEAKGPGLVGPLNLSSETEGLKLNISFEHTGFQFEKNPEVAIEAVQHHSGGKVSEALRRAFRSLEASTKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5P7</accession>
    <name>A0AAD2G5P7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002137">
        <property type="protein sequence ID" value="CAJ1963327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF71">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="523"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="826"/>
            <end position="1094"/>
        </location>
    </feature>
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        <location>
            <begin position="1124"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1189"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1436"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="335"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="378"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="464"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="551"/>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="603"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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        </location>
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            <begin position="679"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1021"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1150"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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        </location>
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        <location>
            <begin position="1783"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1839"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1873"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1963327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2352" mass="267234" checksum="D0CDFE88E9DFC0B9" modified="2024-05-29" version="1" fragment="single">DVDGVMNWLRNGKTESEDPTGDFTRIDQMLPKKKGQKPKDRACEIESALDWMRNNNVSPQDVNMQPQFEKLPSIPVTRRSPEDRKADTDDILGWLRQDCNPAIDPTGEFTRVDQMLPKKKGQKPKDRSRDIENTIDWMRSVGVKAAEGDVALGPEKLGSVPISRRTPEDRLDDVDRIMNWMRNPQDDSMDPTGEFITVDQMLPKKKGQKPKDRAREIESTVDWMRNMGVTVDDESDEPFNVLPSIPSSIRTPEERKDDVDGIMNWLRNPDIKLDPTGEFTRFDQALPKREGQTAEDRATEIEQALDWSRNNAIGSGPSEEDGEFDSVGLLGSTRRSPEERKGDVDAVLSWMRNGKPESMDPTGEFSKVDQLLPKKKKQSPDSRAREIEGALDWMRNNGVTPSVGVPPADFEKIPSLPVSRRSPEERADDVGNALNWLRNPQNKSLDPTGEFTKIDQVLPKKKGQKPEDRAREIEGTMDWMRNKGLAPSEDAPEGIFQKLGSVPISRRTPEERKGDVDAVMNWMRNPQDDSADPTGEFTRVDQLLPKKNGQKPKDRAREIEGALDWMRNNGVSPTDDELNPSFSQLPSVPVSKRSPEDRKKETNNVLNWLRNPQDQKLDPTGEFTRVDQMLPKKKGQKPEDRARDIEGALDWMRNKDVKPSGEVPQGTFQKLGSVPISRRSPEERKKDVDAVINWQRNGKTSQEDPTGEFTRIDQMLPKKKGQKPEDRARDIEGALDWMRNSGVEPSNESPEGTFEKLGSVPTSRRSPEDRGEELDNVMNWMRNGKDNLDDTNGEFAKIDQMLPKKKGQSPLERAKEIESALDWVRNGASDEPDENTVPLSKLASVPISRRSPEERKGEVDAIMNWLRNGKPKSEDPEGEFSKVDQLLPKKKQSNDDRARDIEGTLDWMRNRGVEPSDDAPEGAFETLGSVPISRRTPEERSGDVDDILTWMRTNKNDQDDPTGEFTRVDQMLPKKKGQKPEDRARDIESALDWMRNTGVKPSDDVPPGTFHKLSSLPVSKKTPEDRKQETDDVMNWLRNPSDDQMDPTGEFSRMDQMLPKKKGQKPEDRARDIEGALDWHRNHPVDDDIVDDEGVFEKLGSIPVSKRTPEDRKEDQDAVLDWMRSGKNATKDPTGEFSTIDQLLPQKRRQTPEDRARDIEGSLDWMRNNDVPSAKVNELPYEIAGMMSAIPKGGNEHSRPDDDNLDWMRYPGSPMDIEDNSLPFNRPGDVNSIPRDGPPREADGEMNWSRDKNDSVPGVSDEDYHPFEKPGMLNSIPTSREDSPGHDDDNLDWIRHPGVGTQLDEEKLPFDRPGEVQSIPRDGLPKSEEEPETDWTRYPNNSVPGVTDEALPFDRPDLLSSVPKPRDSDDKGTEDNLNWTRYPNQKVPGVPDEEMPFTKPGDVRSIPRHGETKPEDDSEFMWARHVPEDEYEVVQPFEAPPKSNRVLRSKRPEEDDEEDELMWIRSVFPDYAPTDEEDVFDRPGDLRSIPRGGKPKTSDDPEFGWKRSGGKVIPGVPDDEDIFIRPTVRDVPRDGNPDDEDEDSIGEWSRSPSSRSLVPEEENVFDRPGDIRSIPRAGKPHEEGYPALSWNRNPAWKNQGEPDEENVFDRPGDLRSIPRTGRPHDQDYPEMFWNRNDVSSPDEQSDEENVFDRPGDLRSIPRDGRPRGESYPEMTWGRNAVGPKQLSAPEEENVFDRPGDLRSIPRDGRPKDSDDPEFEWERQPSFKSIPGVPDEDNVYDRPGDLRSIPRDGRPNEFDEPEMNWQRHFSSKSIGINPVEEDLFDRPVDARLIPRDGSPPDEEEEFGWQRNPQSDEWYEEEPFETPTSSTPEVRSKMPEEFDEEPEYDWSSDKPEDAQWKKEEPEYDWSGGRPDQLRAVEPDFDWSSDKPEDALWKKEEPEYDWMVTKPNDALWSKEEPNYDWSGARPFDRPEDALVTLPTTSLDDDEPGEYNKPFDDISEYTELGEDKPRPVTGVPCAAWTMLALGAAAGGAMTSGTAPQGAAVASQFANNNSVGSTTDRLYPDPGALPNCSTDANCQIIMDGLSPVLPPDVLGLFDLPGTCQTKARDWLRTGKDILEFKAERIRQRYAMSVFFCEMDGGDWITGDSWLSDLHECDWYNKVGLDPCNRREQMEMLRVTDNGLAGTLPVELFILSNLYEFTLANNMMSGTLPQLFDKFKELDTLVIPFNQFEGSFPHQIWEYPDMVYLDVAYNGFTGTIPTDIDTRMPNLQVVFLENNNLSGPIPENLGNLKQLHRLHLDDNKFTGKIPPTLGLPPRISELLLHDNLLTGEVPKELGDLNRLQLLTLHYNSFDEQTIDEHICDLMYNKQLELATVDKATISCGCCSPGEESFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G641</accession>
    <name>A0AAD2G641_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS20231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040002148">
        <property type="protein sequence ID" value="CAJ1963577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G641"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1963577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="713" mass="79816" checksum="D33415505F9A003A" modified="2024-05-29" version="1">MGDFKAALISIYGANANYLEGQEDFLRLILENQNSNIHGTIPCGRGKSLTFFLLAKAAILSGVNDGVSFVVLPYKFLVDHMVQVGERMGLETVAVQCSNIAKGATPSPLVENIPTIVFFTVDSFAKMMSDNGGKLEQWCDEGILRRIFLDEIHLPFIEVGFRRSYDCFPQIVPKFVSKGIQVITMSGSLSIGVEAATQKWLGTKNCKSRRTASLGLAGIPIHVKPIPTGDGLQSVIQDRLKFGHIHVFCWTKRDCAKIYDCLLEIVTLNQIGVVTSDTSEEARQGASKTWFNGGWKILISTTCCLVGNENLNCKTVICFGHMYNLASLIQAMGRLRVNQRNGCKAICFLDVDKEVDAASDLMAHLSCCGLLSDAVRKFVGPTSLNNFYRTSECRIALATKEFGARLVPNCGECDNCVTTRIQERKVNMNCDAQQKHEAEVEINREFSSLRDKMDAACVVCERVSCKGEDCMTGRCHICGIEGHNTKECTMRNCKPKDSLEGRACRNCWTFGPDHSSYKCKHRRWKRLVLYNGSPRQIKQLYMPTEVESKHNMVQIYKKLLEKPWPAKRKTTHPIATPTQKRRMEVENVPEIGIWNDIACRVPTTASKSVTNFTILKSPSPCTVFRLKGSEFNIHHPKAPLYIPYRKRKGEGLAFSFKVVSSVVFDGQIKKGHSPFLIFYCFSLEPLFNLLFLTDEKKRGIAPFVFSIAFCLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6T6</accession>
    <name>A0AAD2G6T6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002184">
        <property type="protein sequence ID" value="CAJ1964432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6T6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="221" mass="25066" checksum="43FFEB16E5420590" modified="2024-05-29" version="1">MPSENASNLTQEEVEEGLQLRVAEAQTWPAKLPFDGIVDYDGESADLFAFVTNDIETRKARFDSKQWPPTKQGLKDLLHHLKLIGLKHGSEFTYDASKGWLTCYRSKPYKGTKLQDLEQFNEKGVLLQYQHKSYHHDRLRNRPDGQTCPRATHTSKDITGDKLCSCRLRLGIHSSKKAGDQSHIYISCKGDNLHKYHAKPAAQLPIKAHNLTAEARQIVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G715</accession>
    <name>A0AAD2G715_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS21024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G715"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="60"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1965253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="452" mass="50593" checksum="8E5752A2016FC34D" modified="2024-05-29" version="1">MKSSSPPIAPLRDTESSVLQVETEAEVSPYFVDLEKLRKADLDNLRQTGLLGSDGTGVQLLRDKHIEYLSQVWQQPLKPGFVTLDSSRPWILYWCLHGCDLLDGLSTIDDETRCRMVSTLEQCWTPMSIQDPPVTKEEDPQYYVGIDNSTDFVLGGFGGGPMQMAHAATTYASILSLCILATDSTGAEESSSRAKQLLANIRIPLYRWMLSLQTNEGGYRMHHDGEVDVRASYTVLCCADLCQLNTEHLRHEKVAQYIQNCQSFEGGVSAEANCEAHGGYVFCGVAALFLLRRLDLLDIPALTSWLARRQMSYEGGFSGRANKLVDGCYSFWQGGANAIASSFYAPGDQINDPWLERQGDEALGFSLLFDAPMLERYILLCAQDIRGGLRDKPSKPRDFYHSCYNLSGLSVAQHCDFAEEAYGDLEQTRVARTHPCYNIRIDRVRDMLQLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7X0</accession>
    <name>A0AAD2G7X0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS21514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7X0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="103"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1965927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="328" mass="37164" checksum="68B528F269E261AF" modified="2024-05-29" version="1">MAESERKIRENGLQSPYSPAQVSTWVFLPFLLVEFGLVASPLMPIAVSIPVTLVVFGIAGAATYYAYVTMSTDPSDVRIFSNPQNRKNDKVEYQAPTRTTDDTIKHCWICEADVIQTSMHCKFCQKCVEGFDHHCMWLNTCVGKKNYHLFLKTMNCIISLLVSHMAVQIALLIDMYANPKGTTRELSEQWLGLTSDSSLQSSKDATTLGVTIGMGAFIVMDLIALSLMLQLWNFHQKLKREKLTTYQFIIKDNQRRREARHLEEELDRKRDSQKAKALAEKRKGDYFKLHWGGILATSCGIKSCDPLRQEPQRTTKTGDGDDEEHGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9U6</accession>
    <name>A0AAD2G9U6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS22489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9U6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1966903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="389" mass="42669" checksum="9003F25077ABD305" modified="2024-05-29" version="1">MARVVNASISPAFHTQVAVIGAGVVGLAIARSLAKCGMEVFILEKASIIGNETSSRNSEVIHAGIYYPQDSLKAKFCVSGRHSLYEYIQSRHIPHKKCGKLVVATQPSQVSNELRALFEKAQRNGIDNLKLVSREEVKVMEPNVECHGALWSPSTGVVDSHSFMYNLLADAEKHSAQLVLNTAVEDAVVDSDGICLKADGAWIQCDYVINTGGLWANHIANMFHRSTSWKPPIAYFAKGNYFRLQGKAPFEKLIYPVPEPGGLGVHATVDWGGPTVKFGPDVEWVEPSVSNPAEVSLDVDPTRGDKFYNEVRKYWPGLEDNQLIPDYAGIRPKLNHPSLQSPLPFEDFRIYGPETHGVQGLIHLVGIESPGLTSSMAIAEDIRIQVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA48</accession>
    <name>A0AAD2GA48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA48"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61406" checksum="BA43831AD7B54A75" modified="2024-05-29" version="1">MSQRKRTRSGDNALVGGGKGTPKLLACIQCAVILLLVMMTGCWMYVVIQFRKPSGVQSQNASLDYEILHEIITPMHNFGGKPQQASGLRQNGKKYIDHGNLGDGDDDAEVEEHPMSIEEIKDQHAAAAAVEQEILEKSKSQKQVDSKVVQQDHDSSSTTNEYFKYKVSTKTFLKKSLFNKEAIHDQVVKKDKKGNILHNAIHAVRKEDLEDLNIPIPDGWNTTTMEDALKGREPLVDILHDAGVQELDVAAVLSLPKWDVVTKLYGDNGPVIIGLDTCKQFQETIPLDQASIGIAGLFNTGTNPMNMYLEENCIMPHIKRERHGGMRFQVPWGKHVPASWKWNNTAGNDQNTNKTNVLPVVMVRDPYSWMQSMCKHPYTAKWLRPKGHCPGLVPLALDKDRGYKSSTLDVTVKYKATAYFDSLADYWTQWYEQYLHADYPRLMVRFEDLQFHSREMIDAICQCAGGVARNEDASFSYVVDSAKSFGPGHGGKKQAKTNMISAMIKYGSETHRLDSLTKEDMEFAATHFNPAFMDLFEYNVPEVPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBW2</accession>
    <name>A0AAD2GBW2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1968014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052326">
        <property type="entry name" value="Diff-Dev_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33459">
        <property type="entry name" value="DD-GDCA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33459:SF7">
        <property type="entry name" value="DD-GDCA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042260967" evidence="2">
        <location>
            <begin position="20"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="632" mass="67838" checksum="A4D0354546C62C60" modified="2024-05-29" version="1">MKIAKSFCLLFVAFVAVVAHDVKDNQHERERSSSNVEAKQIRTKEDARTEHTGARNEVHPNAKHTRTKEDARTEHTGARNEVHPNAKHTRTKEDARTEHTGARNEVHSETKHTRTKDDARASLTPPDMLCEYDYYGECGGYICDGICVVAQPDGSTCDYNEGCYTWKCVHNVCEHSDHGDSGDACDDNEDCQYDLECASDGFCVPRACDSNFSCGSGKCVHNVCKDWDHGAADEDCDDNQDCVYPLVCAADGTCAAAKLAGAACETNSICESGKCVHNVCKDSDHGDSGDACDDLYDCSYGLECASDGTCVPSACDSNFSCGSGKCVHNVCKDWDHGAADEDCDDSEDCMYPLVCAADGTCAAAKLAGAECEVNSICESGKCVHNVCKDWDHGDSGDACDDASDCSYDMECESDGTCVPRVCDSNYSCGSGKCVHNVCKDWEHGAADEDCDDSQDCMYPLVCAADGTCAAAKLVGAACETNSICESGKCVHNVCKDWDHGDSGDACDDASDCDSWDSWNNLKCAPDGICRPQLAGADCDSNDQCYSDKCVHNVCVDWSHGEAGDKCDEDKDCEAWLGLVCGSDGTCEATPKLGIGAVCVSDVWCESDYCEIDEMQCIMSSSCEGVCQDGYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBX9</accession>
    <name>A0AAD2GBX9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBX9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1205" mass="133909" checksum="60EDCDA9F9EC7F47" modified="2024-05-29" version="1">MSKVVDKSIFDRGISWRMLLLLSLIASIQDASRFAVRAFSNFRPSQRSLYPTSFVETFRGPYLGSSSSSSSSRIPLHARTSSKVDAAGTSTKVLYQKVIRPPPSLPDILFLGYLVEYLESYFELPNGLPMIYETNKPKKEAQYIIEVDSPLSPASEVTRMEIEVVGIYTTSKDDKKDKNGNKSTSPSTPNMAMVVVKKKKDPQSSIPPMMENLFTDSEKRILKALDRGLEDFVQGKIRFREDVDVKDKKKIPNFRTAEQVIEAELMDEAPSSKSRSKTDPEDVVVEAYATLDDGDKDSQAKHKTQEKSKPKVHDKTTQGENTKKPETKSEKPVKTKAAKAKKGGSNSVAATIPTAGSEPAGLDFAVRAAKQAAAKRKARVAKQESPATEDYAVAAARKAAAIKSPPEDFAIAAARKAAAATGKKNTTTMLKVAKQKEASKTARTPVKGAARPQVIEEQAKPIAMPEVEDKSPPALSRDNLAQSRSFGYTISRPSERAKKGKTKTAAKKTASKVKKGSGSKVASASSADTPIAKSQGGSGVPSTAAVPTNSKAKPTAKTNAKPIPQEAETTEVADDKKMESKPMPSREQMELDVMKAAKEVIEEMVEDSEDMTAEELLRDVLKFDEEEKKSNEPGSGFVSGAFEKAKEIMQDRYRQRQRMDTKIFDGSKPNIADPNQFPVDADAPSSEEEELRRMFQAGEQIADTRITKSIKDNVDLGYGLGNSEDEVDQLIANEKSISNYAKVLDDELIELELQINPTPGEELDGPMKNPMFDVMSGPEVYNPNTDMDDVNYPGALPGTKELRLPKPLKEVKKQAEFATGVLKKLRTVETKDDNGSVGAKYFVGETEMTLKQLTDLQSVVSEASQIGIITDPVTLMKESSRLQLLVDELWNQPKERFREIAENYKDLILSDNFVSLVKERMQNMVERDLDAFRRDDESLKEPHAREREILGEVVVYAQLLLKEVRALGAELEAQQLEVVRSICKVAMDPRYTTEEETAMALTDAVRDMRPLLDDMFVAYLKYAVVEEKGRLARAGLLDDPEHNQWLFVLQIVQQGVYNEIAIGINRHIDHIGYVIRMKTPRQRRMLLEKLIDVMPSLDVRPFVQVVENIVGALGDGAKGEFDGIDTLGGWANELLQLHRDVKELLPPERIALKARDADEWAERQRQRLLDFRKVSRQRLQAANDNAHLQDEIEALGKRGEIERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCD4</accession>
    <name>A0AAD2GCD4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS23710</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCD4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="374"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="553"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1969440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="630" mass="70501" checksum="539190D9495BCE19" modified="2024-05-29" version="1">MSDFIPMPQAGRFHGRGGNRNHRNHSRGRGRGGRGGRGGRGGRGRGGRGRGRGRSYGNVDVSFDKIEEIGEPSTDSISIAVEGCCHGELDRIYERIEDHQKKTGQRIDLLICCGDFQSHRNAGDFLSSSIPPKYRRLGTFPRYYAEEKKAPILTLFIGGNHEASQPLRELYLGGWVAPNIYYLGAAGVVRYGGLRIGGISGIYKSHDFKMGQYESPPYDRSTLRSVYHVRNVDVYRMKCLQDSEERLDVMVSHDWPLGIYQHGNANELLRKKPFFRQEVEQNELGSPANQDILFTIKPKRWFSAHLHVKFEAIVVHGREAKTSNESETAELVPSQVAQKDLANNNAEVAQKIDEESAVAEEETTFHGLESNKNCNGPDLTELMTKFLALDKCLPRRQYLSVIHIPVGTHSGEAQFEYDPEWLAIVRKTNHLTCKEKRPVSVPSQPIEVSVEDAKWVRERIVEHNGSLRIPTNFSRTVPIYSHPMFQGRCRPFPAMGNPQTDTLLSILDLEHFITVPFDSSSLLDGNIEDENEIEIDDISDNENGAQDENEIEIDDMSEENGGEAAIPPVEGKKDPTTDEKETKIGNEPSIGNTKDVAEDENEIALPHQEEDDCSGHTGSGPVVKKVRYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD08</accession>
    <name>A0AAD2GD08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside-diphosphate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002502">
        <property type="protein sequence ID" value="CAJ1970334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="40904" checksum="8A602ACC1BD4CAC8" modified="2024-05-29" version="1">MLSRVFKQPVSFIAGRTGSRSFSSNGSGGSGMAMPASLLALAGASYCYYDSSRQNEALTSQVNDLQVELSGKTNSAFVFIKPHACKGKPGVVEKVVEDKFKSVGIRVTGSGEILAEEIDKKLLIDNHYGAIAKKAMELTPSQLNVPDKGKAAFEKMFGESWDTAISANKVYNAKDAAEKLGLDVDGINDKWSQLKRGENLIKFGGGFYCGKIGDIYVMNGFYMSMRAAYCNKGEKIKWYTVSWPTDSLAWESFRGDVLGSTDPSTAPKGSIRRTILDDYRKLGLNSKPNTGDNGVHASASPFEALAERCNWLDASVEGDQFGKGLLSAGVSKETIKQWSGDCQVTVDGETTEGKTMSVFDSLEDLDADTSLAKVAKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD09</accession>
    <name>A0AAD2GD09_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS24206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002474">
        <property type="protein sequence ID" value="CAJ1970183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD09"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF18">
        <property type="entry name" value="RETROTRANSPOSON, UNCLASSIFIED-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="377"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1970183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1130" mass="125911" checksum="B17B514E4FC0EEAB" modified="2024-05-29" version="1">MSEQLLQGDLSPILPDLISSPSPVASFPSWDDDSVSTSCFSEIDAHDSDPPDPPPSVLINQHGTVSNYNATTTIATSIAEFAQDHLFLSETSADMEPAFPVIWDSGASVCVTPHKRDFAGTLHPPPNSRTKGIGGPIEVTGCGHVAWTFKTTTNTFRTLILPAVLVPLANQRLLSTSSLLHCHSKETISLSSDGMLLSGTTSDGAFTRPIAVDISPTNNLPTATAYRVIDSPQPTPEAHADDVTVAIDNLHSSQGPAPTSSRTDRNSFMMSSIAKVSRHNINLDNGDKEWLKWHQGLGHRSFAIVRFLLRTGTLAKSQRMRTLHTHISKRVEPPKCAACCYAKAKRRAIAKANQGCSQLSSRQHSLSRSRGIRRSSVSSVPGRTYTGYGKGHKSEMFRGSAIFVDNATRYIFVQHQKSLNTHETLRAKEMYEANCRDLGVVPQKYRSDNAAVFHSHEYKQHLEAFSQTQKFAGVGQHHANGIVEKAIQDIQSTARTLLIHLAIRWPEQADLALWPMAIDHAVFLHNHLPDVDTGLTPMDKFSRQRWPHSKYHDIHVFGCPTYVLDKKIADGKTLPKFSPRSERYVHLGFSPFHASTVPLVLNPRTGAITPQFNCIFDDWFATLSANVDDVPTFMEEQWQHLFGDSQFQFPTDDNDPPSLTPQSQVPLSYELSALDSFEPSTSRYAGTQPTLSDPSVFREPSQPSFERESVSVEREQSPPANIPTSTNTGNPTPSPLQREQQTQSKSPHITARETPIDLPSSSIPPTSSSGPPLRRSTRSTRGKPAPILDPNPHSKTYVSKPLPSSNLAEINPSNDPDFNDTENLHSFPKDTPFLANEDLVLTTSHPSYRRFKTQPESDDGGICGFYDLHFSYLGYTTTNTPKFVFLDSKAPPDSIEFLKTGTTDPDILSWDEAMAGPDRDKWREAALKEIRALEHKRTWLEAPESNATVRVIPGTWVFRVKRAPDGSIIKFKARWVLRGDLQDLDMDTTAEVVAWSSVRTFMVLSLKLGWVMKSIDFTNAFLHAKLPDNLEMFAHLPRGFYSNMRSITGERTVLHLKKSTYGTTIAPRLWYEHLMKAFHELGFESSSYDKCFLIRKDMMIVVYVDDCGISTDKPEKIDELVNQLKSKFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD99</accession>
    <name>A0AAD2GD99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS24429</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002513">
        <property type="protein sequence ID" value="CAJ1970411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1970411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="157" mass="17881" checksum="30CB1CFBC644EBBF" modified="2024-05-29" version="1">MIPSVSMRAARLAAFRASSRRPAQQARRWAGDMPVPQSQNAPLWRGHTVKEEGWETSMYVYAALAVVLQAAIIGFAPETSIESWARAEAKARLALKEKDPDMKFEFGTHYQDLIKQDQLDKWTKFSDRAITPGEDDDDDDEDEDDDDDEDEDEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDN0</accession>
    <name>A0AAD2GDN0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002425">
        <property type="protein sequence ID" value="CAJ1969754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="262" mass="28542" checksum="D1DB6214D7A5F03B" modified="2024-05-29" version="1">MPSTQSQNRNRRRRGADHKVIQFATPPEDETWMDDKDVKTPEGTSRRNLIINAVGVGLLGASGWASASLYKTNVYTPDGFQRIYPTQFIAALGDPKAKEGKGAQDWGIWRVDPGPRGVWLKQYESQLAQQNNVAPAGWTFDPNNWWVEEHGLIMEAPEFPLSPGRYLVTGGRTTTTGLTIDAQGGWKLDEGALYDVTHLPCRSAKYTPDSSSSTPGSPLTANPSNFPVAPGAAMPPVQGCKKQDYAVLFVVGKVIGKGENRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGM7</accession>
    <name>A0AAD2JGM7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGM7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="234" mass="26622" checksum="BA3E65729BD11E0A" modified="2024-05-29" version="1">MTNTSMTNTIINYMNKKEENWDSLEHALPTYMPPTPPVSILCPARKDWGSPRITNHVSFTQTNQRRNFMPDQEDIQSRKKRNREIYGQIKYHYLCECFEERVLPQLRSTVMDTLCVISDDPEEEDDCHFDSSLDVGSIDDNIDSAEDPLEDTISNGEIPEPLQEQSDNAAITGIPPDGMGSGWTECGKRYSLQRAKLLITHMAEDPFTKALGSGMTEQGRRYSRRVANRQNGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGQ5</accession>
    <name>A0AAD2JGQ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="367" mass="41413" checksum="724CD560730A32D4" modified="2024-05-29" version="1">MMEDYTNKHEDSSNSASFLPKHLRDMRKYLLIQNSGNLNELMNWTIIILGCRLFLRVDEVLSLQIESFVPQYFAVKEKKVLSLCVKITRKTGDDESEDQHFQVHDDPYYPEFSPVRPLLLFIAASKRMQGYIFPVKEQMFEANATKAYHCNDFLNTLHYLVKDVLGMDLSSGSGRHHLYAGTHILRKTALLLAYWGTKMGKINHSEMNIHHGGIPIEDLAAIYNDPRNDSMLCDGRREISTSIAADLGDAATLFALYSRLGNRDPDQMVGPYMPISMCIANASDDSHPINNKTLPELAAWFVFDIMEVDKDTVLKANIPLLCSMAHSLDHADNAVNITPTNILEELRAHLPPDLFSQVAGHLSSSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH03</accession>
    <name>A0AAD2JH03_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH03"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="464" mass="52477" checksum="132F26F516BEE0F6" modified="2024-05-29" version="1">MEVTEYQFQGIEGETVPNFVLKLIVNPGIRELPRYLCANQFDLQEVSLPEGLIKIGHGAFDFCCYLTEIKICSTIESIGEAAFVHCKRLAKVEFEYSSSSPHQIKAIGKFAFSCCVLLQRVKIPSSLKVIGNDAFHACKILIEADLSTTSIAEIPHDVFLDCRSLQTVSLPKSLELIGQNVFHKCTSLVTVMVPVESHAIELEGNSIGLCNALANIVLPKWSIANKEYFDKCTLLQDRFGKEADDIGACLTHRFDNFPLHRICYYYNSSAAALELCDCIQKTKEEEESPLVDRFGMTPFHVLCSTIGPSQDLLQVLLDKLPHYVLGWRDANDNMAMNYLVNNWTDENKILLQKVLQSWIFSRLEHWCSESGRRRMIPLVNAVLAEDDKERRITAFVEACSVFAQYEGMEATSILEMTLWKGKVNHEWSNDGSNRRALEREESRFVCGSSIVMPSVMMFLTTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHP5</accession>
    <name>A0AAD2JHP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12573</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16989</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001766">
        <property type="protein sequence ID" value="CAJ1950414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001960">
        <property type="protein sequence ID" value="CAJ1958014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="203"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="278"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1958014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="368" mass="42143" checksum="2889261781AEBE94" modified="2024-05-29" version="1">MIVTANNDNLRGDSFSFSKIEDDELVSLLTSPLLSMDGPCSSLSYLHLPPFSFDDPFDDPRMEPSPIESQDEGTHNAHQIMQSLYDRSMQSLYDTRLLVDESIFSEEDNKSNDTSKVGPTIDPTSKVGSKTSFGDFFSHNDEEPYCSTVASSKRSREGFFLSSNHNNQGNQENPAYKRQRTTTSHAAQSTFGEESTPRFRPYQDKQWRAQLQKLIQYKMKNGHCCVPHSYQEDPVLARWVKRQRYQYKKFNDNNPTSTMTTRRIQELESIGFIWQSHASAWQEKLNELKAFKQRTGHCNVPSDYCENPTLATWVKCQRRQYKLYAAGASAPSTTAMTVHRLQTLESLGFVFEPQTAVKTSSRCKHDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIC5</accession>
    <name>A0AAD2JIC5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001826">
        <property type="protein sequence ID" value="CAJ1953509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIC5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="345" mass="40137" checksum="D711F156829CC606" modified="2024-05-29" version="1">MLTLLSRLSTVLVNFNQFLMMLKMNYASQGEHDPTAEQNNQHIKALFRVRYHRMPHKAIPRIITEAIAKRVAQTSNFYPAKGGISAYYSPHMILLRRQVDYSKEFVAELGSYVHGYGHDTRSDHRSRTIEAIYLGPADNMQKGHKLYDLNTKREVTRPRITVLPITDQVIKLVEAHAAEEGVTDLQTYSRRNGEIILDADLLAGVDPDELWDEDYVPADIEIPPVNDMNLRKNDAISDEELEELIEDAAEDILESRRIDDKRQHKYDEADRTVDRMLQRIKRRQEEDDEEDMDFVQDQQPESDIEMDIDDEELKDMIDEVARELDRLSQPIEEETMFSVEDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIM9</accession>
    <name>A0AAD2JIM9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001859">
        <property type="protein sequence ID" value="CAJ1954230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIM9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="588" mass="65363" checksum="AF803A4877BDD758" modified="2024-05-29" version="1">MQPPPNETNQQSATRASSKTRSGCANVPGVGAEGGADRVKASARGTVFFARVPNMDARVVPFEASYMESDKCCRGSCVPAPFWTQPLPADLSRATVHITPLLGSLALTGIGTAPLQPHHDSQPSLLVAWTAASAKVTVYVGWTPKEIEIDGDKSLLAEALLDDRLCVISDGSYKLGLGTAAVQLLPRRGGKERIIVRCQTPGLPDDQSAIVCNGFLALLNTFSDNRVTPQQAQFDLVSSIREALARSRASWEPSHVYGHIDKAKSFLCLSWWSKRNVEVDAWASRLNPEQVQALSALRKRWHKRQTITPEAHLETDWTSLARAMSSLPAGVQRWTTKHVVAPSASAEWKRRMATLDQWLHTQVTDPAIKHAILYLLQGVCDPSLPRSRLVWVCLCRTFLSQQRIGYQGLLEGRLSVQWAALQAQYLPSRGSQRSPTLWVSRLLHQLILLGFHMWEHRNSVQHLEDNVQLCECSRLVNNGIHSKFDMGPTDLPQVVQRMLAVKRRTVLNKPLVDREEWLKLVRMECMAYRRALPPSPAPLTLFRGINALKSPRPVAGRVGIPLILTRATSVHQMSPWFKLVIDSSLYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ92</accession>
    <name>A0AAD2JJ92_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001890">
        <property type="protein sequence ID" value="CAJ1955483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ92"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="171" mass="20117" checksum="BB2F6FDD6AAC03DD" modified="2024-05-29" version="1">MFRRHGEINSRWKVDQLNAIAPRLNSPTQSEAVARETEMAQNKILYPAKLDKSMQRSAYFETNKRTVKSNIMLKFVTKAMDIKLRGEANFTTTLEDPIELLKRIERVMKKSADAEYDFLDFWEANQKFFAMKQGTTKNLMHFKEGFLRQAEVLQDLYVMKKMVQYDVCSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKK0</accession>
    <name>A0AAD2JKK0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKK0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="391" mass="43346" checksum="3C5C910014D867A9" modified="2024-05-29" version="1">MGCFQSSLTNRSVGRLLAASPPGEKMEDESVASLSDVVTVEASNMQRGAVISSPVPVSPIHDEAEEAVGDSSHGDDGTDEKPQHEQLNATTGDLESISNQSIQNMTEATDLVQRRTRSSAQSAGSSDRREEESIKLDREKDFSSPSKAKRIRRRIDGSPIFPACNMPRKTVYLFRHGYSQGQAAQKNGLDRKTDQSLRDCALTERGIEEARAIPKQFLGDERDSIEVVFSSPLTRALHTSILGFPNKNIICHFDLGEIGTKAPENIPRKMAAVLQDLREDIEKRDDSLTLDTTTFQPSTWPRDTAPGVIKKEKVKKFFQWLYKERQESVFAVVCHHNVIKTVVINGEKLRPKNAELISCSLDSNGELFALNDPEKHEELPVAALDFESIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLB6</accession>
    <name>A0AAD2JLB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS18996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1961013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="5">
        <location>
            <begin position="31"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="5">
        <location>
            <begin position="174"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1961013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="354" mass="40007" checksum="FA5D4BE50CCB6956" modified="2024-05-29" version="1">MLKAAKNVFKADEECPVVPLEPRRAKGNEIAVMACGDFVAPQEKFLELEGVERVLRGYTGGGKELPTSIKIHDHTEALLIEFNPNTISYSQILVAWRQCVDPWEKETTQHRAAVFWKSLSQQNEALDFLGSLQSQQPSKKLHAEVERARRFFRARQPYAAIPVDPKHEDNEVAILACGDGTGPLNMFQEIGGVQRVITGLTGGKQENPKDGKPLDHTCALMIEFDPLVLSYRQILELWHECDKFKQGEITLHTRSAIFWKTLPQQDAALQFIEELKASKPSTEISVDIERVRKFYEVEVYDPNAATIVSPQHQKAKFSPRNSPVIVPGQQKRLSANRKPCLSEVTTPVWKTNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMA0</accession>
    <name>A0AAD2JMA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042185587" evidence="1">
        <location>
            <begin position="29"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="255" mass="28946" checksum="DE6AB95DD54DD882" modified="2024-05-29" version="1">MFRQSTSRTVFQSLGMSLLLFCGSLSSSSLLFFHKNNVFASAAGASGTQKFKRDIGDDCSDLTSEACIREIITIQKCPIACSELLEEPGTIARTSDSEIYQQRVTKQDGKQITLEEYEGYITLFVVIPLVPNAQYYYELVEHVHEIFPFTVEIMILPISVVDDNEYDAAEIIPQANSKVTFLKHEERTDFMIYLSESEVFGGEDNLREFANDRASIYIISSNGQFVERMVAPKLIDLEKRIIVYLQQLDPTFLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN39</accession>
    <name>A0AAD2JN39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="187" mass="20680" checksum="BAE4D58F3561D798" modified="2024-05-29" version="1">MMMPGMEAAAGAEGGAAQDSNKIVDLLDFVEKKSCYARNEDPRFPHSNLFIGDSRLGCKSDADEQLILHIEFNQFVKIHSLKFTAFNQGNEPETSPTVVKLYINRPNLGFEDIDDVDETQALELTSEDLREGSDAMLLKFVKFQRVSSLTIFIEDNNGGDVSSLGGLKLYGKTVATTNMCDFKKNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNF0</accession>
    <name>A0AAD2JNF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS22361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNF0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="147"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="256"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1966778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48333" checksum="AB7041F14489E3E9" modified="2024-05-29" version="1">MSDNDSRAKEAAKQLFCGGIAGSVAKSVTAPFSRLTILYQVHSMVTTKHDRPAYAMNLRGGFQKIVERGGIASLWKGNMTSVLHRFPYSAINFYVYENTLDILTGIGGKHEEVDETVAHLARRMSISTQVKRPSKTSTSSQSQTNQTKPIHKFIAGAVAGTAAVVGCYPLDLVRTRLTTELEGREHYKGIRDAFRKILAEEGIMGFYSGITPTLMVAVPNFAISYSVYGTLKEHALDDDLFYNLRRIDADSGEPRLGLLLTVLCGATSGCMSTTLTFPMDTIRRRMQIQNLHIAAEHRLTSRQQLMRLVKDEGLISLYRGLTPEMLKVIPMVGTMFVVYEWSKEMLDVKHNRNFIIMARGNQFVMSVVWIILLCFFVWPLAACAGLLWLFLQPFEACFDVVGQLNRFLEKIVTWPREFGHAIASGTESCPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPB5</accession>
    <name>A0AAD2JPB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS23610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPB5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1969248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="283" mass="32607" checksum="DF8A5968DD713C56" modified="2024-05-29" version="1">MQNRIAEEEAGLTKKRTPWEKAAEEKALAYVALSGMEQMHPRPSEEVFAQNRKFLKDADKKLQKFAREGHDVETAFREALEKEQGTMLQMNAMAQAWKKENPNKTNFEYGGPETQRLYEQIAAPPKSSNRRGQFYTCDYCKKSSTVELKMCARCKKVAYCNRDCQKTAWKAHKKTCVEWTKTKDPKELALSWEELEAFGGRPAEGKVLEIRAMLDESMMRQVFQCKDRLGKLRRIAAYTNSRSIPGLRQGSIIKWKNPKFHYFMDGSSGARIEEEDLPNVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPD1</accession>
    <name>A0AAD2JPD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS23520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1969066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="61534" checksum="CF97BBDDAC447CD9" modified="2024-05-29" version="1">MSPPLLSNVIITMMDLTCGHVAILAVSVMFLLVASQRRRRDHFPMAPGKLPLIGHALALADSDKFYSVIQEWIAGVGQQEGIYEFNLLGKRWIVLCSTESVMACLKLRPFKMIRAKILSRSIDSLNGDGIFSSNGDQWRRERRIVGPALNQNHVRDFFPSIQLVAKRLVQKWTKAAAQKVDIPAANLDMTAFALDIVALSILGLDINTIHHPENQLAKDVEELFRITFLRTLVPIPYWKIPIIGPYLDGFREGNQRIVATLMSKVQEYRKRKANDDTSIDNAKNQTFVEKIIDISEGEKVKLNDEQIVGNLLTVFVAATDTASNTVSFSLWELANDLALQDELYQEVIEYTNGSGKRSLDDLTMEDALECFPRLRSFLFEMLRLKGPGPLLFFEPVESMEFLGKTVEPGDVLVTVGPSYPHNKKTTKSEVPFGPNGEPPQEFCARRWLTTEPQEEKKEDVSPTCIIGFRPKLIVPSNREAGFLAFGHGLRVCPGKMYAHVEMVTVMVHLLHNFRITPAKDCPKMTVVSRFTETFAEDLKLTLTSRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPK1</accession>
    <name>A0AAD2JPK1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002458">
        <property type="protein sequence ID" value="CAJ1970076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="298" mass="34052" checksum="C328C5DFC0A29BB3" modified="2024-05-29" version="1">MTSSETTQTHEQQQQIDDVEHHCRTNTTTTTWNLQIFQIWMLVISLLFGGSSASLLYLYEMRLRPNARQAEVLTNRSMTLIIGYAYTRMILHVSTGKLLAEHSETFQLLAKPMNDDCAFILEPNSHVWVDRALQLTVHSRRDRLIHHAVASIWALLVIEWSSSSSFFLNDPSLFVTGAIMEGLAKFSYFFDFVARMNRAFIRNQTTCGECWESKAIVGADILFISKTARKQAQFMKLGFGVFLLAHFVAPFALVGVYLGSRRESTIVAWKLALPFIFVLFNLLDTSQYKALRKQSEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JQ38</accession>
    <name>A0AAD2JQ38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS23767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JQ38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF64">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042257574" description="PNPLA domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="189"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1969548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="586" mass="65627" checksum="59C55EE5FA1BB45E" modified="2024-05-29" version="1">MSTKSYSTILYVVLVFLSPFQISGFVPLGQLKPSFVYSHGNGHSVTTSPSEHDIEEMNNNKNNDNNLKPPSKRLRFLNKLGFKRVSHDQKEIREAASAKKVPETFEITNLRDLDSYFADKQRRFRNKEGKIDSDSLIRSLSVCGDTQIIGSTEHLDYVHPVAKLLHERKANGSQCVEGGKRDDGCKIALVIEGGGMRGCISGGMVCAINYLGLRDAVDVVYGSSAGSVVGAYFITGQLQWLGPEVYYDKLTTAGKNFIDTSRLLRVLGFGLADPRLFKDVLGRRNNGKPVLNLPFLLKETMQRTKPLDWEKFAQRQKVQPLKVVASGLKRQEAVVMGMESGHFTSIEEMSECMHASCLLPGIAGPVMNIKSNENNDPEKPKFVIRNGLDDPDYEPVADALVHGPLPYESAFKEGATHVIVLRSRADGTDVTGKGGVLERLIFRRFFLRKNKLPNVFQYMSHQLHKKLYAKNIIEMNEAAHSTRDYKDTSEPHTLALALPPGSEEIARLEVDRKAIFEGVRRGFARAYDALVEDPKERGRGHIVAKEYFPDEILDYSPEDIARVDDSAFRIFMEQESISPKSWANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JQ89</accession>
    <name>A0AAD2JQ89_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002515">
        <property type="protein sequence ID" value="CAJ1970436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JQ89"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="371" mass="42028" checksum="3FF4A0F54DAAFC97" modified="2024-05-29" version="1">MDTNADFCSLGKNFVIMSYTPRLADVYAYDPALPPTNVPIVSGATAYDCPQSGNTFILIFKEALYYGNRLDHSLINPNQVRKFRIPLWDNPFDEMRNIGIKTKPIFVALKAKGTKLLFDSRAPTDQDLANCPHIDMTSKVPWNPGTVQLGKVSIVHKDPIDDPRSNEAELRQLDPIMQGMNEWRTVQQTIVDGERFFQQVGRMDDDARFADVPVRPSFVSTERHTKATAENLSERLGIGLHRARATLRSTLQRGTRSAILPLARRYRADRMFLRPRLKGKFSTDTAYFNHKSIRGNIASQIYFHKSGFYSCHHLSKVDDKQVGPTLKKFIADYGIPEHLTMDGAAVQVGCNTSFMETINRAAINYHISRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU06</accession>
    <name>A0AAD2PU06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF29">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="278" mass="30631" checksum="37D92D9DC5B2353F" modified="2024-05-29" version="1">MGESKSDDAMRENQRDTGTGQQLTQQQDAPTDSATSDFIPTDLTESIPDNSSEAPPTASPTIVPLRVACAGDSLTLGRSGNSGASYPTLLQRLLGTGFGVRNYGRNAVNVIEGFGVPYIGTHNFGFSMDLDPDIYLLMLGTNDVRFWKAASHRFFAGMKAIIKQVRAASPGVRIILAIPPWVQPNDFGISNDILLNDIQPRIREVAWAQQVELVDMYKPTFNQHDMYSFDNLHLNEKGYAALAQVWQMQILCNNNGVCDIGESCETCRQDCLEQCTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV91</accession>
    <name>A0AAD2PV91_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="47"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="287" mass="32156" checksum="CBA76100B8A584DF" modified="2024-05-29" version="1">MGDAISSLLFQPPPPTYLHPSRHFWLNNSKGFRIPAFFIERPNAQVTILFSHGNAEDLGMIYDWFNDLARVLRVNIMAYDYTGYGKSNGHPNEECCYADIEAAFEYLIEVRRLQPEQIVLYGRSLGSGPSCYLAQKSAKEGHSVGGLILQSPLLSAYRVAFDFRFTMIGDRFANVDKAPKIQCPSFIIHGTQDEVVPFWHGEELFLALPQQWRAKPFWVEGAGHNNIEALLRPTGAFVDKLTEFLDLHVSARRGRIAPPTSVPECVPLALREIRSAAGEETASSIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVC8</accession>
    <name>A0AAD2PVC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVC8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050343">
        <property type="entry name" value="RsuA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47683">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47683:SF2">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="98"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1954439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="312" mass="34581" checksum="9E846D7D3FD722B5" modified="2024-05-29" version="1">MLVLQCGAFQNLIVSFYLLVLIAPTIHCLSLSSSSSPPPPTPHERTVVLLLYKPPNVVTSHVSNDDRPTVYNQVQDLNAYVGGEIMEGSSFQEWTGIRSKVHAIGRLDADTTGLLLLTNDGGLVHHVTNKNAASLRDKSNVATITKTYQALVMGHQTEDTLRCFWEGVDIGTKYGGRTAPVDNVQILEYPNHKSTLVSITISEGKNRQVRRMFHSIGSGVMQLKRVAIGNDYLTLEGLQEGQWRVLSDEEVKRTLQWEPKVLENKTGSIGGRQGSGSPRGKRPSSTNDRQTIGKKRRRPSGKVRRSSNTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVU3</accession>
    <name>A0AAD2PVU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="1">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS16705</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001943">
        <property type="protein sequence ID" value="CAJ1957416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVU3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="5 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="33"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1957416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="645" mass="71886" checksum="8DE14C0DE37863AA" modified="2024-05-29" version="1">MIRQGAATLCKRHAANQLKVNTGASGALRREMCGLVAAIDDVWGKTSSARSDIAILGKETMNTTSKILHHRGPDGMQVSAGTVGEGETLARWSMGHTRLAIVDPSNRSADMPFNLSFKTKKGDKIIHLAANGEIYNHNLVYKDLVAKEGWNHDRISGSDCEVIAHAFAQWGGPKTAASLDGMFAFVVFEEDVVTGEVKAFAARDPVGIKPLYYGRTKCSNSSDDAAAYVFSSELKALVGHVDPSTVVAIPPGHYWTPEEGLVCYYNPEWLRNDDYAPWEDPNHTVTDDEIREGFTKAVQKRMMSDVDYGFFLSGGVDSCIVSHDLLPLWREERAKLGDDRPIPAYTVGMENSPDLMAARGMVDALGGEKHVEHHIRSFTPDEVFDLVPKIIYHMETYEAELIRSAIPNWLLAERAAQDVKMVLTGEGADEIFAGYLYFQDAENPRQLQNELRRIYGMLGNVNLHRTDRMTMAHGLEARVPFLDTEFTRLVMSVDPAKKIVDREAVKSNSRGREKTFLRELFEGPNSNGSSIPRPILWRAKAMQCEGVGEDWVSILQRRVSSLVSDAEMAEAHITYPINTPQTKEELYYRRIYDENFHGMEHVVKLWEGGGRAMGAEWKSDMYTREGLANVDLLSHALQEGKGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX20</accession>
    <name>A0AAD2PX20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DEK-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS20588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000779">
        <property type="term" value="P:regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044198">
        <property type="entry name" value="DEK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468">
        <property type="entry name" value="DEK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468:SF1">
        <property type="entry name" value="PROTEIN DEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="6">
        <location>
            <begin position="560"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1964349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="614" mass="68453" checksum="80EC4EB2C99D9C29" modified="2024-05-29" version="1">MDEKAASPKIEDNNQDKQEPTKSRRRSSRSKSITDSTAVEPAAKMDIDDEENEKSKDSLTDRSEKKSSQQATTTKTDNDEKLSSSKGGAPEAAADQKKDETISASTTADSNTKSKSKASTKSEPTEDISKTEGAAKDSEDNKADGNDDEMQEESAESEEDEYSEENDDEDGSNATRKRQRGRSTDSIRAKRSRVKPTNRYEPVDFSVPKEKAATSKSPGRPPKRSASQSKPASTPQKTKGDYITVIKGQGMKLGDIPVIRKRVEESDIDSPDLYLVHRLLYSYKGRGSNKLFKTHILEYCGYMRKPMEGEKEEKVEEENAGNETFMSAKVFKYSIEKLKLFMDFFEIDRSPNKDGPLNKEAIVDRLLDFLCAPSLESMNPTDDSSSEEEEEEESHDGDAITKEKEEKDDSKTAKTTADDKKKDDAATPEEQVAKKDGTDITKTEEAKKDYSAKETGAETKGTKPVDTEEQKNDAEPKGTGETPKDSQKSSATAEAKEKQTPKEESKKKEESKTDKTTGNKEQDEGVDRKTANSQTYQEWCKKARIEGAFYLVREHEKGDEPSDAALRQWVQAYVTCFDMSSATAKHAIETASARFGVNLVHRKDLIREFLVSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX54</accession>
    <name>A0AAD2PX54_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX54"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="240" mass="27891" checksum="FC092EF97F3838DE" modified="2024-05-29" version="1">MEPVPLELVRPASEWIRKLIKMNRPYDLPIFINTEAFKGIVANLIDEDWRLPAEELLRYTSDLLVTATTDYIKSIRKIESLPMLREFLLFTSSELVGTLMEESKAQLSQFINREQVPYRHDLFENLSKLRSQRLMEELMSPIGTDHGHMQKPAIRSAVKLVFEQKQARSMDDHMAEEMQHALSAYGKVAEKRFVDTVPMICIEVMQKYDRRLNDILSNVMESEIGRLVVASRTAARHREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX63</accession>
    <name>A0AAD2PX63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="383"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="520"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="604" mass="68395" checksum="51A6DEEF18B36912" modified="2024-05-29" version="1">MSKSPDTISNKSSCLRRCDCSDRGNTTNQLANCRNRHSIYEDTLVEGMQHLSFDQIQHEQELLHGVADEVKLNENTINDLLLRLEMHLNRMKKGTAFESAQRQDPSYVSNRELQLAFLRAKRFEPKGAAEKLINHFKYKRDLFGEGSLVRDITAQDLGQDDLTCLLEGFFQYSPFRDRSGRTILLEFPGIRSKRTIRTLLRARFYAAANNVETMVDLSKGTVIVSYFVEKYQDHLNGSGFVETAKFYHEAVPLKTDGFHLCCSSSFECMVTRACIALIPHRDRVKSRVHFGSHTECQYLLASYGIFRAALPLKGPDNEMDLNHHNAWFQRRKLREIEKPQHMSVHIPSSDVFTTHQRSTPCHRNSSSSDSGNANDVLCLGKRIKGVGNERLHSLALSYATAYRNGSFSNRRTIVSGIIDEVHRHGGRFLKPDPQVAGSMPSEDEGKIVWVELTRDEQRAKVTQLFRNLRHHRSRQGSIVSNNATAAAPPSLLPSGAPVSTASSLSTSPPVIVEKIGPHDVLFGYQLDNPGNQRLRELVFGLADEYNRTDRGEKKKKVLQLLGTIRNRGGRFLKPCKDGTGWEVVSDEVARKKVSMQFRNLRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAR2</accession>
    <name>A0AAD2CAR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="6">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1910178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000064">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1910178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="315" mass="35359" checksum="58498F794D8DF659" modified="2024-05-29" version="1">MQRLFASRVVGKACNRRAAMIHANALRRASSNAGQEPYLKGDDTHFGFETVAVNEKEGKVREVFESVADSYDVMNDLMSGGLHRYWKDHLLDISAVASMSDAIRQYPGKELRILDVAGGTGDVAFRFVDAAQCMERSISSGEDPISVTVCDINPEMLRVGEKRARERFGSDLIDTSKALSFVEGNAQSLDFEDNSFDLYTIAFGLRNVTDVDKGLREAYRVLKPGGRFMCLEFSQVSDPILRQIYDTYSFNVIPEIGHFVANDRPSYQYLVESIRKFSNQEELVFRMEKAGFELAKYSNLTGGIVAIHEGWKPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDU9</accession>
    <name>A0AAD2CDU9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000142">
        <property type="protein sequence ID" value="CAJ1931336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="18002" checksum="270C9B96013A6568" modified="2024-05-29" version="1">MIIASPTMGTSFDESVAHIKGFIRNREDTLVLGKRSRDGRHIASVDTRHRPPNKWHAMPKDERNAIMEERKRKKRKIEHGAKKDKTAPKDSGAGKKTDKKNGRTTFKELKRRIAKLESKESARTQDGNDNDDRTGGNTPGHAANGNRTNPALNRGQPGDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG40</accession>
    <name>A0AAD2CG40_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1897271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042225619" evidence="9">
        <location>
            <begin position="22"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1897271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="657" mass="71662" checksum="3E6108932DC0803E" modified="2024-05-29" version="1">MMFNKLAISALALLAMPFARADEGEEKMGTVIGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFMDNGDRLVGDAAKNQATINPANTVFDVKRLIGRKYSDKSVQSDKKLVPYNIVSDKDKPVIEVTVAGKASTFAPEEVSAMILQKMKATAEVFLGKDIKNAVVTVPAYFNDAQRQATKDAGTISGMKVERIINEPTAAAIAYGMDKTGGESNVLVFDLGGGTFDVTLLTIDNGVFEVLATNGDTHLGGEDFDQRVMQYFIKMMKKKSDVDISGDKRALQKLRKEVERVKRALSSQQQARLEIEDLADGFDLSETLTRARFEELNTDLFKKTMGPVARVMEDADLSKSEIDEIVLVGGSTRIPKVQALISEYFGGKEPSKGINPDEAVAYGAAVQGGILSGEGGDATSEILLLDVTPLSQGIETVGGVMTKLINRGTTIPTKKSQTFSTHQDNQNVVLIQVYEGERSMTKDNHNLGKFELTGIPPAPRGVPQIEVTFEVDANGILQVSAEDKGTGKAEKITITAEKGRLSEDEIERMVQEAEQYAEEDKKVKERIDARNGLESYLYNLKNTLDDDEKGVADNISAEDKKDLQDMIDEALDWMDENPEADKEDYDEKTKEVEQVANPIMRNVYAGGAGGADEDMGDFDDGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGR5</accession>
    <name>A0AAD2CGR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS3714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="4">
        <location>
            <begin position="51"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1934354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="289" mass="32303" checksum="84D2A38226F9B9A3" modified="2024-05-29" version="1">MAPPQKRKYEELKIRGPPLYSQGNFADEQDTLSKRGKSIAPRCPSIDPTQTALLIVDVQPEYWSECPAVRKDFPHFPAKMSSLIENCRSQGMKCIWVRADYSYDRSPWLQQFTRLHQGRIPPVVRPSSKWEGFATPEKDELVVTKTSWSSTTDTCLLDILRNAGIDTVLVSGLITSVCVQHSAFGVFEAGYRTILVTDACADRGKERHEAALALYGDYMYELRTVRSVQRELVTAVDKTPEKIVKSDSFASLTSSMMTSHTSLSSLDQEEIEEEQVEGGPVNVEVSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH01</accession>
    <name>A0AAD2CH01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GxxExxY protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH01"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026350">
        <property type="entry name" value="GxxExxY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04256">
        <property type="entry name" value="GxxExxY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13366">
        <property type="entry name" value="PDDEXK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1932701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26107" checksum="BB93F0F95F21862A" modified="2024-05-29" version="1">MKPWNLLSSLIIPSASLEGQMSDSGITNQLTLERELPGICDRLFQEIGSQQSEWTYQKCLAIDLLQAGVDEVHTEVKLPLTYKGHVVGNRRTDMILELASGEKAIIELKALEQIRLLHRVQLEYYMYYANIPEGYLVNFPHDDGLPSVTDRCEFDYQVLAGGSIVEHLVNPRSKLYLRNTPDKREVEVIHIYRKDLLIDTGGNDDTIFPGSPSLSQLLLEGSGGPMETESMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHQ6</accession>
    <name>A0AAD2CHQ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000406">
        <property type="protein sequence ID" value="CAJ1934884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHQ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="192" mass="22002" checksum="6FF7A66C81397AEE" modified="2024-05-29" version="1">MREQRASAEGKESGYSGEYKEDLSRGPARLENVLKHSLNIYNYVEEQKKQDKEGYEHKLDITLANLGDKNATESARRQRDYDANVEKQHGKSLCGLARQRQQGVDTTPYMAGRVVFAKCLKAKNMNAMVVEAVARELLNESYKAAYNEGKPVSITYTSIRALIANDVVRRWKEEHKDKPLSEEDEKELRKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIC3</accession>
    <name>A0AAD2CIC3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000403">
        <property type="protein sequence ID" value="CAJ1934881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="186" mass="20153" checksum="EDE34EF688F2DA5F" modified="2024-05-29" version="1" fragment="single">LVVTERGGKEWAPTAQEGRPLTGFGLPQPLAYFDVTSTWPDTFDVLLPSDVGCVLGDGSACCCCSDVPEDCVREDGSCRNTREVIEEVYSGAQTDRCFFNSPSAPWSADWLLAWIVTSGMSLMALVGAFKKTAFDRLLEAIGIRLDHKLDQITDSMAIDVPAEAAMAQATAIPEARAEVEMQRVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJA0</accession>
    <name>A0AAD2CJA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000469">
        <property type="protein sequence ID" value="CAJ1935414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="217" mass="24326" checksum="091A968B85D37B80" modified="2024-05-29" version="1">MNLLGKAKRSAQKTKLRGDIVVLERKANGRKKAFGIEFYDLITNDKNKLLGVSAGTIFKGHREELKEPFERARDDMAGKQAQKDVHQKDLDVMEVKGAHTLPSDTMGEKVNKAGAVMSNAANATKLGGKMALLDREMKIRKEQFGLEVFEYFNAPQDGKRTSMKKRLSEKLSGVTQHEQDIQACIDAAKRDVGEIEDQIKSKRTQMGFLDEESQPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJW6</accession>
    <name>A0AAD2CJW6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS4281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000424">
        <property type="protein sequence ID" value="CAJ1934944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="348"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="576"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1463"/>
            <end position="1666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1934944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2104" mass="234582" checksum="4306201A2EB8C584" modified="2024-05-29" version="1">MEELLLEYEKEDAFNLKEIEKKYANGEYRNQQQVSKSISKFADALLRCTFLFEDNNDAGEEFKEGDSDVNAEWLLNICSQVPSELGNEQLAVAVWDASKLEGEGNQQDALFAALGASEEAVAILFEIVPKLPAIQRNIRRSQLGGNGNAQASPFFVPPEDILDEAELNRQKLRQEALDAAQVAAITKAEAEAALGPSRFGSTHTIRRTSDMKEQKMAQKAAKRAAQAMQRAKAAGAIIEESELLAVSNAGVVGAGGLMGHTDADLQALQDSLQPEGSRYYHKEEGLPSGTIREDDDVIGYEKVTIPPPILDKSKLHPRLSIDDILDPDCALAFSGTTTLNPMQSTVFDTAFNRRENMLVCAPTGAGKTNVAMLTVTAHFRDVGLIDGNNGRDMDTGDKVVYIAPMKALAQEVVEKFSSKLKPLGLIVRELTGDMQLTKAEANSANVIVTTPEKWDVVTRKSGSDENALGNQCGLLIFDEIHLLADESRGSVIESVISRLHRLVESRQKQLRIVGLSATLPNYEDVAEFLHVPERGLFYFGPEYRPVPLQQTFVGVTGNIKNRKLIEDKMNDVCYEEVKDALSRGYQVMVFVHSRKGTSDTATALTQRASAKGELDRYFVTQGKEGRSGDAYKRYADRAKKARSREVTNHFYNGIGIHHAGLLRPDRKLTETMFADGAIKVLCCTATLAWGVNLPAHNVIIKGTDVYNPEKGKNIDLSILDVQQIFGRAGRPQYDTTGEAMLITNHQAVGRYLDKLVRSVPIESSFIKQLSDHLNAEIVGGTVTNLNEAVAWLRYTYLSIRMKKNPLAYGISADKFADDPGLRSHFMELVRNAATYLSTNRMVNFDPQSGNLGMTTLGRVAAHFYIQGESVVIFNESMELKPFPTDADLLMLVASATEFENVRVRPEEQDELDNLQQKCPLELEGPINDSVTKTFVLLQMFISRNRPKGFTLISDTNYIASNAARVSRAIFEMCLHTNQAGTAIKMCRIAKSIDNQFWWFQTPLRYFDREVGDTAIKALESRHHGRTMNYGTLDSTLELLDMTPEEVGQICRSKKAFGQKIQRMIEFIPNPVVSCRVLPVTQHVLRFQVEIVPEFEWHGRWHGGAVSFWFWVEGSENQRIYHQEHVVFTKRTFPEPIKLDIPIPAFQGPGNQYLLRLISETWVGVEITQPISIDEIRMPQQDTVYTDLFDLTPLPTTALQDERYEKLFSRIETFNPVQTQLFHTLYHTNIPIFLGAPTGSGKTVIAELALLRMKKLHTDGICIYIAPLKSLARERLKEWRARFGESSMNWNVLELSGDTHHDQKALANADVLVCTPEKWDLISRNWRGGIGASKAFIKRVRLLIIDEIHLLGEERGAVLEAIVSRTRFISKFLQNQNKSNGNGGDSGPYETVRIVGLSTAIANPQDLSHWIGIDVDSISRTARHGLYNFRSAIRPVQTKIHIQGYPGKHYCPRMASMNKPCYAAIKQHAPDRPSLIFVASRRQTRLTAFDLISYAASEGNPKMFLGCSDLMIESVVENIQDEALRHTLAFGIGLHHAGLVSSDRDVVERMYLTGDIRVLVATATLAWGVNLPARLVIVKGTEFYDGKVSRYVDYPLTDVLQMIGRAGRPGFDTEGKAVVMVETSKKNFYKKFLYTPFPVESCLKERLCENLNAEIANGTVSSLLDATGYLTWTFFARRVKANPSYYGADSGSEEDVEAFLLSVATETVSKLKDQGCVVSEGDEVEDDLRPTTLGTTSSQFYLKYTSPKQMEIGLRECARLLMDSLDEEKEVGKTPNVSLRPYLPGERVDEVSISWLLYTLSFTPEFDELPVRHNEEDLNEGLSENLMWGADTAGVQSPESTYIYRSSDVYADPHTKGFLLIQAFLEKAQLPISDYVNDTRTVMDSVPRLLAAMHFVASNQYETDGYADVVSQLFRTKQLISTKSTLSMNPILQLPGISKKTAEKAVSELGDGAFWHLRQASRAQAEQHLKNFGPPKQRNYASALNNLLSYPKVTVTESKIAHRVDKVTVKSKGTLTLKIQIDRKKGSQDEPITLGIVVASNASRRLLGYQEVSISRNGNWTVDKSIDFDWEAARSDGGEGSGTVIVRLLLDSVKGLDSELLVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKT8</accession>
    <name>A0AAD2CKT8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000463">
        <property type="protein sequence ID" value="CAJ1935380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="460" mass="53129" checksum="E66DE20CEFAE5AD4" modified="2024-05-29" version="1">MLRQTIIVNEGDSPLAYKSREVTNPVMQYVSFFDNNFERKRKVEVWNGASGKNVEPLLRSIQSFRNIASEWGLNQGRQKKALFKQFLTAEPHMTYQRISDTHGNSVQDFEDSVDEFICEYTGENPKYQANMYLFDTSNHIRKPYNTEIGIHTNRLKTLFMYHNILPRNCSNVNDENDPAQIRNRKMALFCSFPIYWQGDFINSQNDPASDDNIMWKDIVSWMTQKKRTVDRKKLVQESSQRQTRPGNRTGGRGLHQNRFGGGGGRGHGHGHGHGHGHGHGHGRPSNGYQPYPRPSNSPRYSQGNSQGFQRGGNSQQQNQGRFQPRNPNNGGRGRGFNGQGSGRSQSGRFQPGRNYQGRGQSQQQQSQNYYAESHYNQEAESFAAEGSVPEWNQDGMSYGGMPSAEQYQHQEHYYQAEENQQPWNDQFNFEQEEYYPEEQEAQEHFSYDEDSPFSFHEEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKY0</accession>
    <name>A0AAD2CKY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000480">
        <property type="protein sequence ID" value="CAJ1935489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKY0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="181" mass="19102" checksum="997087879B5599E8" modified="2024-05-29" version="1">MEFQKGTPIRFVAGKYAGLTGWRDASKTWGTDGDNETSAPVIVDQTRGKGLKSSVVSKGSFREILASTTAGNYADLVIENCPDIEKDLVAVTRKLAKCNAGEHIDDINGLLVVTMADAVDWQSKLTGAKAATRNFAPRNKANMKKRKVSKGAESAADSSASDSVHSMSTGGSGMTTSPCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLH0</accession>
    <name>A0AAD2CLH0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1919826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1919826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="381" mass="44547" checksum="74475DC46DAB7C91" modified="2024-05-29" version="1">MKRKADDSPSLWRAKCIERFQLKPVPEGWKDAVAGGTETAWKRYFEYRSQEEEKLSVYDPDHDDYCYDEPKCDFMKEWKAKMRSVTCREPWFSWTPKFGRLVWVDEDEYRTAEYYSHIWSPYAIPHALGLEHYYHHKVTSFIEFRSIWSYRMIDFEIDSSPTVECTELCSNHNDDVDTSNLKMATVNKLRRFLFGSDSEESKIILCDNHRFLGILFGSMGTMKLVSDTMGDMGNVYLGYVWSPDEELRKKLFEEGVSADDCPDDDDEPPESFDYYNPREISWLEHRVMEITGTLGPVSTHYEHPKKKKEPSRTLTPQQFQQQAGGLIDMMEMITNEGKSEEERNDKESSKRFEEARAVLKSYAANGDAVAALQTLEDLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM94</accession>
    <name>A0AAD2CM94_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000358">
        <property type="protein sequence ID" value="CAJ1934678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="701" mass="79868" checksum="768AC66CEFD0DC07" modified="2024-05-29" version="1">MSAGRVSRIQRRYEENIRQNNNAFSNTSRQQSQQSQQPSWRQSLQQRQQRLQQQQQQQQQEGNGDSPQATWGDSMRNGFTTLREVKPVQGLTSLVTETIPKATNRAWMKCGMDTTWEEFNFGNNPFQGGNGFFEDFNGDMIDDDSIVERDPFDFPIKPNQPSSRRKEEVPTGWANFNSPHFEAQAVRYYSPTNATATTAGTSSTMNTSIDDSFYDHGEKMFDVKAVPITEVIPIHSLEPPSVLLSPQMLDPDQPSDEEPEGDEEVLMSSKSKNKNNKGSPSTKAGRFNPFGGGFRSTKPVAVVVEKAAATEHTKKQARKEEERLRKKEEQRLQEIREEKAREEERIRRKEALLKREEERLAREQERILQEEERMMREEEERERRRDERRRREIEIARLKEERRERELRKREDFEFERIEQTRQKSKSDDGGLLEWEDVELGSSFESVEVDWQGFPPALDPALAASSPPRRQSRKRERREGAPRAPREPRESIKIECPGCPPLCCRDFCANHKKSLFGLVILLLVAGLFAGIYFALDMSGALEGVAEEDPLNPDCVAVLGGFAIPNESLYPTVRLSWVMDISSEGAWASMPALTSITRTHFQDMVIPTLAGCMGTPPSSDGRYDILNGYVRSVRDVGSCRVGEPQPCARVLVDFVVYVRGESSVLDLISHISAQYNTAVAETMDQMENVRQTGLVGLFEQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CME3</accession>
    <name>A0AAD2CME3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CME3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="99" mass="11725" checksum="5CAA9AF5E26434CD" modified="2024-05-29" version="1">MVIRNSDYPRLPRMHWGELIYATPGCGKTYVANKYRDVVDGDDLIVEATIEVAPHFELDYYDDPRKAIFQYFRYINFNRRINHVESLQPGLGENGRRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ25</accession>
    <name>A0AAD2CQ25_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ25"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="558" mass="60107" checksum="965CED367882C584" modified="2024-05-29" version="1">MGIFKKKSRSDVSQSENSAPSPSSAASYPAYSGTIYEQQQQQPNNGSPRSIASAPINGSSYKKKKGFGSKLKGLVRSNGKQKSVGDSSKSVGSSASEEPPYDPPQQVRRPVSKGNNDDNDYSSSSSEEFHQELGTVTEVNEDDYDSDGELKPKSKRRISPTPKKKRIRAKAKRLGSGGEDGEFAETITLVILLVDPTTRRFELLQLEQNRPQDLKVKDVLAQVKTCVTEASLKQLQFVGLVDRLCQTHKPNVPLTKAMGFDAKKDILVGWPMGVPVDQLVQSVRPILGDRNMGKLLDMNGFDTKGWVEKKKTKDSILDKPTLIKEEKQGSTLSILAFVLIIAAILVGVDTCLVHLDQKGFFIQPLMDWANVMESTKDLALQGAQAAKEAFNGNNTAAVAMVNTTFAAVEESAMEAVAETKAMVKDFVPVTTTLPSSPKVMFDNAKDMVNMAAVQAKIAEVVSEARASVPAKVAEVVSEARTNVSAGISNVSAGITKTIANASADITNASETISNTATPKAAAAAAVVTTTSPPSNNPVWEDYILIGLLVCWFLYWMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ44</accession>
    <name>A0AAD2CQ44_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000241">
        <property type="protein sequence ID" value="CAJ1933107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="292" mass="32643" checksum="A36817D3AAC20A0C" modified="2024-05-29" version="1">MLAPNIPQPSIYIPQPSFYISKFEHGVAKGAAGLIGNNSRVRQLSVSKNFNENRNKSDSVCSLLFMPVVYIPGDKMDNPKCNNNPTLNFLEQDPNHKRAISNCYQLQIGRTDHLGFSSLLSRMNAPTLDGDKALAGCWYGTTLGNPHPVLYKMDPLLVLPGIHSATFVPLQGCFSLVFAAPKCEDNSKHSHGLEAFQEWKETLSLSSKMVLTHMLLVFENVARQELRTPDVDLLHFQCTPVEAYTFPCQQWKCCTIIENDKASQEYMILHPMVLESKDNKGVEGSEAPEEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS29</accession>
    <name>A0AAD2CS29_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042235680" evidence="2">
        <location>
            <begin position="23"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="619" mass="62564" checksum="2E991BFA85F27CD7" modified="2024-05-29" version="1">MPMNTLAKIFLAAVLLAGSANALNPECSAHELCRGLSGFCCPTTEFVYLECCEGFGAECSLYPACERLGLEDFCCPTADGEMLECCGENNPDGPSSCSAYQRCNDEGLTGECCPTQDGENLDCCGGVTDPSESPSLAPSEPPSTTSDCSQFPACAIAGLTGECCNTIDDVRLDCCDGIVPSNQCADYPACATAGLTGECCTTIDGVRLDCCDGIVPSNQCADYPACAIAGLTGECCTTIDGVRLDCCDGIVPSNQCADYPACASAGLAGECCTTIDGVRLDCCDGTVPSNQCADYPACAIAGLTGECCTTVDGVRLECCDGIVPSNQCADYPACVTAGLTGECCTTSDGERLDCCDGIVPPSQCSDYSECVAEGLTGECCPTADGDRLECCDGVQSLQVVESTQCSDYFTCALEGLTGECCPAANGERLACCDGVENLALADVVVAPPPVPAVADAGAAAPPPGTSPSSPSSPSSPSSPSSPSSPSSPSSPSSPSTPAAASSPSSPSSPSSPSSPSSPSTPAAASSPSSPSSPSSPSTPAVVARTPVTRPTRRPTTRPTRRPTRRPTSRPTPRPAPSGKVSNKSSSKSGKSTSDKRKKKRNLGSSSLSGETVDVTKVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSK9</accession>
    <name>A0AAD2CSK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000857">
        <property type="protein sequence ID" value="CAJ1939848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSK9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042125096" evidence="2">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="368" mass="39880" checksum="BD699734974D9DA9" modified="2024-05-29" version="1">MICNQWLVVILGILQFSVANGASKCPLCSRLEVVPKRLDYIVDTNPFRTCGEAWLKLGSLDKNSGQCSSLQSRYRESCCGDAEPPAIYVPPAPAPTKSNSGGTEPMCRICGNDKYPGKPNARVVARYVGDFSCGQLYDRGRNGLIPGFMCNPLKHFSFSVCGCGSSPPAPTRNPTRPPTRNPTPQPISQTTRRPTRNPTPRPTRNPTPGPSPRPTRGPTRNPTPRPTRRPTRRPTRPPTREPTPEPTPYPTGLPTPEPTPYPTGLPTPKPTPGPTREPTPGPSRFPTLAPTRGPTPQPTQLQRPTPSQTLELSTPTTGTGTRAVDRRKATPLVGFKKDMKFTRRAQGGANSIVRGRGSSPLIPNEVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU86</accession>
    <name>A0AAD2CU86_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8431</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU86"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="26285" checksum="8FC0B1DCEB13BDF5" modified="2024-05-29" version="1">MTQPNIEASMCSEHPEYSGNLNDDSLDDHHGASSYEETTRTTHVHFLEQEVEYKATISRSEITADEAIASWYTHQERAKLMVKYIKTVERRQSGKKPKKNSSYRGLETFDQCDALELQYTIEACVDAVLLEQHRQWTENIVDWEALARVSIECSEQSKALALAMAKSDKREAKKANRRMALMVEESMRSISSTSIESFQDMKKLVPHKASQQTALVMGSTISPVIELRSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUF4</accession>
    <name>A0AAD2CUF4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUF4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1217" mass="137210" checksum="0AA81CCEF7008D55" modified="2024-05-29" version="1">MKFKPQCQDYHSEATSLWLERYPNKETEPLRIHTKLLEQEENEVSNEVYEKEVDEASNEREQEPPISNPLMDSFKSQANGSPSNARASNAKKKVSKSNLSKAEANSSTPSRHRRRKRRRDSQKSLSPTSEKKISEASLRSKDHTEVPATNMPSCEEPGLRPTVEENPLQGDPRNGQRRWLRRKLPTAASQSEPSSLEATEEISTERPSQPCVEHEAMDCDLDASQMGESRTTLVPPIRFEPQQCPQEMMECNSSLQMDLVKTIQREEDYEMQPSSDISHDETGPQDMIVEHSDAYCSSPGVDRVRRRQRRLVNAICGSTLGSKGIIVLPPKLFSIYDSPLLVSIWTNIRRSANRKRIANYAWWLDSSQASQSVMIEEIETRASFWRQPMALPYLQCLISFWWRRRAEIAFFRQFSRTISNVAMTQLDHVVSVFTLRHLSDRRQGQRPISIKLRAIPKNAKAKKDLSKLPYRYCLLDILQGNAGTFWNVSLGPSSKRRETLKRELKAIVLYNSKPQNPSLEVQQRLQFAILFAWNLANRQKEERHEEQDTVEGQCSTENQPVLPEKRKALDETGLLPPNKWTMSKLLARSKTELADSTSHHSNDLRLHETAEGSSPPDSTKKQSAKGQRQKEIGQARQTELSLLERFGLAPSTEPTGNGSNPTKGRKKRPPPPIISPEEVPQSKRGKRQARQQDISESSHLEIAPSSMQCDDPVSLHETRKATNVNDVILPEQNDKQINSPKQFSVLSPQGHQPPSCQPMSKVASCRKLDDRSEHYRNWQPKNFDLDGGSVWSFNNDNDSDIQLVTAPNAFDPESNLPSSVGSPSEGLIQNTAHQISQHQTTSRVVSDKKQRKRARKAAKKKKKKESKRKSGKRKKKKQSHGDLFEQSLPESVLQSLEEDATEEVRPCVKENGPTTTHQVTATAQFGMEIGSPDQPIVIDDTEDSALTSLPPQTVRPPLVLLCSEDFLEKWGDYAARLVSGDWQHQVSSRRTNGTSSGRRFCFVDTKLVDTCGVDIELPDRGGIVVSALSSWFNDDGFESLIMRIIGLISSTRFRHLSIFLCADIDQDDATIDRISTIQSAVLHQGEGLTTATSFTLVSPNTLAASIGQSICKLDAAWGLEEAESWLLDDRTFERLLFLVRLVPTLTVTSILQCLMSSPVATGSTEDKSRLWFQSVFQDDRERKRMKSFDPKVLHPAVITQLSFALGINIGDKTVFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUS6</accession>
    <name>A0AAD2CUS6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000591">
        <property type="protein sequence ID" value="CAJ1937045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUS6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="207"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="292" mass="33624" checksum="8972A3BE8E9EAD7A" modified="2024-05-29" version="1">MISISHQGPLLSMNTFPQFNNSLQDECITDLLSSAPEMMIDPLPLHPKSMSSLPKTSSELEPRPIHPKQVSLSDLKAPSLPESIKQYCDEYIALLGPLAVQAPAKKSTKVERRNSGSSESETSSTNGIGYHAFQNERWMDRFQELVEFYQREGHFNVPYKSNTTLFQWVKRQRHQFKLRSMGEHSNLTLDRIHQLDQIGFVWNSHLAAWNDKFKELKDFKMIQGHCFVPCTYNGSSKLSTWIKRQRRQYRKFMAGQQSTLDASRIEKLEKLGLVWDYYAGKDKDGTASSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV32</accession>
    <name>A0AAD2CV32_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS8061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tic20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV32"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005691">
        <property type="entry name" value="Tic20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33510">
        <property type="entry name" value="PROTEIN TIC 20-II, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33510:SF5">
        <property type="entry name" value="PROTEIN TIC 20-II, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16166">
        <property type="entry name" value="TIC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042127377" description="EF-hand domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1942666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="391" mass="42413" checksum="33D6A2583C656AD5" modified="2024-05-29" version="1">MKISMQTSALSFLLLASSSQAFAPSSGTFRTQRLAVERPASAMPSSASVLLATSDSALPDPTQSNSSEADEVQRLRTMAQQLREEAAALAAEQAHKVSDAAMKAFAKFDLNHDGTVSVDELKVGLEKATKNEIPQNRIEKLLQRFDANGDGVLQMEEFASVDRLKNQLDFIVREEKVVALEEAKMAKKKESEKEIQEMRMALINDGEPTTSDKVVSVLPYLFPLLDSLQYAGPWVTSHPDNVFAQVAAVVFTLYRSIPLSGLLAFFALSTLSSNLSFNRLVRFNMQQAIYLDFALFVPGLMAALLGAVGSGLGLPATGVVTEYLSDAVVLSTLATIAYASATSLLGKTPDQIPFVSDAANRRMVTPDMFDEEGKFIGPSRGVEDDEVNKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV42</accession>
    <name>A0AAD2CV42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS8076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="467"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1942696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="700" mass="77194" checksum="4B60E9EE2C5C3127" modified="2024-05-29" version="1">MSSNQPLHRRSSDPRKGKEMDDLNPGRNKNLLQAPSSSEAVLIPFQSVSNTTRPKNPSRDPHKASMAKRIGNLFSTKPPKGRDHHGETSSLAVQYDNATIQSADGQQSVEAVSVAPTLHSQATQKASNRPEKIKEEEKSKKPTKHWKKFKKLVGVKSTKTEKLEPIAVSTEQRNAKLDVAILGRMDGIDPLSLGPANLSSFPINSDDGAIRFSNKNMGENKTTEGAAPPSIDFDPLKLSFTTLSKSWNPSDIVSDSIWSAGGMEQPELVLEGFANERWTLRFNETPSTPTSSSTGSSSFVPRLQPIDDDDESSTLTDNEFPLRGLWNQLWGNKPPSPTLASPSSPGGPEANAHEELLEIAAACSVPVDLDEGTFIIDSPDHLRSVHEMVTIPLQAQRFDSALLVFENLLKGLDQGQNSNLQHLVGATHHNIGLVHLCIGNFGDALLSFQKAVEARIDFFASHHPLVAVSLVRQGEAQFALGVFADALESMKRALAMSPIEDCTRAKILNNLGVVHYQLDNYEESLDAFIAALEIQRRMLGSPIRRQHIVHDASLTMCNMGKLYIKQALFRMSYTVFEEAFVLQTTAYPKDHDIVLSTLKSMALVLAKNSQFAESLPIFRNMLRHQEERFGSDSEHYTETMGMIGCLLAKDLEFDESASCLKQVIEWQTKHLTDANPKTKMTKEALATVEDIAQGKVSIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVL1</accession>
    <name>A0AAD2CVL1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001369">
        <property type="protein sequence ID" value="CAJ1945345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVL1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="126" mass="14236" checksum="608B2AAF8A162C75" modified="2024-05-29" version="1">MNKWTNEDLRVAIVFKIIGRCKEKYYQKMPNDRASRMELWQKVRRLPHPAERYFDGFGDNSGFSDSESDVNSSDSEFEVVRGSSVDGGFSDSEDDVDRGSSDDDVVSDSESEDGSFDAMCRVVVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZF7</accession>
    <name>A0AAD2CZF7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001147">
        <property type="protein sequence ID" value="CAJ1943835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZF7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="103" mass="11462" checksum="F2E241CD54DBE0A1" modified="2024-05-29" version="1" fragment="single">VLDQGQISIQAWSQQNVLLVDVIQYASASILPAVSMLQASFGVNTILTMMTLSPSVSFWSLDYRGQDSLDNRYVESYWEVTNTMISKVKDVVLRDELQNGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBM2</accession>
    <name>A0AAD2FBM2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000007">
        <property type="protein sequence ID" value="CAJ1926852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBM2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1926852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="163" mass="18501" checksum="34C9C96685D75DDB" modified="2024-05-29" version="1">MTHEKQKGLFKCWTDERVGIALLTEVNLQWSAVPRGHKWFDWVKSFTNQGHFSSVSYYEHQEFPTPSAHQWGGCSVTLLHKVALRAKSGGKDETGLGRFSWINIRGRDIRQQQSQTDGPPAGPLDLVVVSAYRLNTCQTPGKFDNQSSSRSELIVLVKWDLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCR5</accession>
    <name>A0AAD2FCR5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1926439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="404" mass="45560" checksum="21D29250D1C43A25" modified="2024-05-29" version="1">MAGSTKKQKGNLRNRKRNEKESKTKDAGPPEENNNKTVEEDDQSLESNQTIWETIRRHPLFWGFVLLGIPYGSYLIFRWVVLQHPFLSSMRPPVALSDERQVLILGSMSSGTSSIAADLRGHQILEVGHEDTDATWKFVRDGTVSWFHGIRFISTTDDADKVIRIAKTCAVSWLITSKSISGNHGFGPTLFGNPEYECSFWNPYFRKCYLSSCHKALLREFGCALEPEGCQTPYKKTLLQTREPWKIITSLSAKYCYKNGKIDDSAYPETLQRLLSSVGWVSANDPPLSCPTQMMEYVVSYYSTILEASKSIDITVYPIENASLCDVARMAGLDSPETTIWQDNHHKYQSMCNGEDIEGTETTPRAKSNEINKGRVSKEDLQPYATPALLKQIDKLHSKLGYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDK4</accession>
    <name>A0AAD2FDK4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000287">
        <property type="protein sequence ID" value="CAJ1933611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="166" mass="19247" checksum="DF346331F267B072" modified="2024-05-29" version="1">MATNGLYKLHPGQASDLDWLECNMAGLFDLDPTHVPQLRPPDFEAYKSDRQPADLFVPETPFIFVIESTPKRDKLIDLTCKLSSSEPHRSPPDEGHVQGTKIVELNYNHNCKRDIQPARIELCLNIDKGEYERVMAYQNIHKWSEIDKDNAIVWKLKRVVCHHHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE78</accession>
    <name>A0AAD2FE78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS2631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000191">
        <property type="protein sequence ID" value="CAJ1931970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE78"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041953456" description="EF-hand domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="619"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="656"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1931970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="693" mass="76390" checksum="183148799D6CF5D4" modified="2024-05-29" version="1" fragment="single">MTKFLATAFIATLFAPGIEAFVTKCNKHNVRRGLLSKLEDDGLAGILQSCSDIEYETSLFVDGHVFVVSTPAILEDNNSDCPSVAMEQSDRLAKPTDADFGIRTVNIHNVTLARDLPGLPIGTFPLSEIANAFHTVQAEVASDPDSMKNYDYILQNCGDFPAHMLTLLNVAFDHQMVQFIAKQLQKRHPTFVQNVRNSPNAMKLLADKTTLDVLTDLQLLELLVESRVKHLYDSSTTQLLDSYSDPSQEHSHRSLSKVDNEPAADRRRLGEVDCGRWYSSSCLAESDIRYDRSASNAIADQNPAWKKFEGFYEGTATAYGPDGRVIEPFYLEEGATSFAPSKMPYSQAKFKMFINITLTGSRIYEQMTSVFPPSPASFCNQSVPEGMQNVILPGECGLNGTSGFYERFGTSTFEKDGRVSMLSFGSTMSGSSLDRKSYVSLPAGESNHFSSYLEGDILVQYASACLDAECSQLSTTIDQYDTSTPEGEEYEFVASTRIFATRIASSRQFRDALGAAYLEYDVPSDQRPSEDGCLSGYCPHESDWCEYDPECGVSPYQEPEAYVLAGPVVGIVVAITAVIFLALFALHRRQMKQKEAVVRTMFANRVAEGITITGSSDVLSPDQLVAEFNKIDKDKGGTLEKGELWAFLESGKVGSMSRSDFDLLFSVIDIDKSGNVDFNEFVAFYSHAMANVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEM3</accession>
    <name>A0AAD2FEM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS3142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000236">
        <property type="protein sequence ID" value="CAJ1933061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051455">
        <property type="entry name" value="Bact_solute-bind_prot3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30085:SF6">
        <property type="entry name" value="ABC TRANSPORTER GLUTAMINE-BINDING PROTEIN GLNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30085">
        <property type="entry name" value="AMINO ACID ABC TRANSPORTER PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1933061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1477" mass="164860" checksum="C420141C5683E3F7" modified="2024-05-29" version="1">MNNNSSMNLPMARAEPAPPTAEEYQALLHEVTDLRDKMESRETSFRQDIARERRRREQMVNTLRRDFNLISQSGNNSPAGGSASTQMYHQNHNIIDEHANFKADEESTPLTSPRAERPKFSGMSLNPHSLNPKKNSFKFTAIGDKNDNSLDRSNRSESSLVVTGPAGDIIPAGNGSDGDTPDGIDIPLLPQDTFSYLAFSKLTSVSLAIAIFVIGVQVLTLTVLAVDMFGEGTPGNVLGIPAGINESTATIQVVAIFIITVAQTDLHDSLNTLFVGYQGDELSDAIGRPTQKWRWTVSLWVRISITLYALMVTFIMICTESDTTQVLLDFTSIEFVTNLDNIFFWLTAYGYLGFGAQEDANLVLNAKPFSIVLSERDDGSTKERRFSVRSSATGQKRQRRFPRLLFTTSLFVIMLIGWGIIFSWIRDGEFLCQTVFVQFADLANPDLAPFTGLYDIGCSDQVSGCRRAKYGESAHGDNHNFSDTAKFAFCIQKNSWGFVFGNETEDVLAGKTSPCNWIAHSKKVSSKTQDSYDIMSTASDPWKVLNRRGIDVPFKGYELRCFDCRHDPLFCGSAAGRGDCVRNRCECRKGWYGRRCEFRSPCELIEFRDPERDVIDGRRFATQYNRMYNDQGEPVEIYDRPVYEGSFLDGDDLGTTYQVFFNGFRWVLTANLGDLLRSQKFHGYWSAKWNQYTVIFYSAQVIVDSPEDATSPEGLLWYRPLVKQRGKAIEGVDLKSIAPFRFLCASCDDDTNPCLYSGICRPGNKTCECPSGSSGRLCQILPTGNGRCDPYFNSREFSYDGGDCCKQTCVSTDEYDCGRDVVTNSQGVKSIGFVGFDNCMDPSIARSVSGSRTIYDIQERGVLNCGLIFTSTWFYNFMTDQCRAIAAAVLDNRNAIQLFNFTNDRFTGLRDKRFDVVFWTDYTANRDVYESSAKSGFNYATIPYYFGGFVFGGIKPFAKCADNGDFFTVGCLDMKICLVDGTSWYDTASTVFPSEVIVTYNDFEATVVGLENGECNIIGGSQVDVELISIRAFGYTGDESNYEVGSKLYFKSFETWITRPDDRVWSRFTSWIFESLVQAEESNVTQATSNLMRSTDVFGDEFSGIFQRAVAAVGNYGEMWERNLPFTRSGMNLVNNGTAPSMVSYDFGRVSDVGPEPSQNSAIRAIIARDSLRCGVNGGSFGFANYNENTNTWSGLEIDMCRGIAAALFDGDDSKMDVIQVTSFDRFSKIENGDVDIVPGVTRTLEREVNFGVNNYAFDFSPIYFHDAMIFAGEMPFAACAENQEFSNTNDLGLNCTDTTICVPSGSTWYNTVVDSLGIDDERLILTSNFEESVQYHVAGLCNVIVGETAKLNTVSLRAAGYLVTENYKFGTQKLTKEPLCLMHRSDDQQFSDLIKWIVFGFFYAEENGYTSVNFFEMPQTNLFGPELTKMWQNSIRRVGNYAQIYEGNIGGAIPRSGMNLRNDLSSPQLFAAPGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGC4</accession>
    <name>A0AAD2FGC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 6">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS5226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 6"/>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1936507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="551" mass="61593" checksum="3A21B2859CD32D43" modified="2024-05-29" version="1">MSAFATIRRLRPLNTRAYNHLSSRYASTATLDLDDFDDRASNNQNPVPDFSDAQSAYQAKSNAELFRAAACFRLCQIPILVSNADRLLRVATRISPTLTDKILKQTLYGHFCAGEDRERIQPVIDSLNSFGVGAILDYAAESDDPASSGQVPDEAIQPTSAVAREYDYESEAKCDKHLDTFLQCINDVAAGSDDGYAAIKVTALGNPKLLARVSQAFEEAKQLFAKFDQNGDGLISREEFEKGYRYFFTVDESTLKNVLDEFDPNNTGTIDYFTWSMMLQPKDLPKITSSCKETGPLAMATPTDEELELIEAMYQRGYKLAKEADRVGTRLLIDAEQVRYQPAIDGLVTDLQQSYNDGETTDKAIIYNTYQCYLKDASERLQLDVQRAERFGYHFGAKLVRGAYMESERELAASKGVPSPIVDTIEETHANYDAAVDFLLKHSAASKLEVEFMLASHNQASIEKAIESMNRHNISRKSPTICFAQLYGMSDHLSFNLGKHGYRVYKYLPYGEVGEVMPYLLRRANENSAIAAGTASELTMVKTEIGRRLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH03</accession>
    <name>A0AAD2FH03_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH03"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042217073" description="Methyltransferase domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46379" checksum="97DA47CE94EB5658" modified="2024-05-29" version="1">MSTQTFLLASFLLAFVLFDDLPITLALSSSSFQAQTKYNDVSQFKNKIIACASTKELTLAVEFCVKPHYRVAELGSQLREVSTQICESCASATLVDVQRKFPKTPPAVSDDGATISKQKQRTAAMRLQSGKEDIFFPEISTFREIKKLQDWREAFFPSLSEPSSYDVLVLDVNAIVGNDLEWTSLSLIQEFQNQQSNKDLIILVKSLGLSQFASRLVYGKRYTKDYNAIPPPHILATVGVQEYRDTIPHVVIKPDSDAILEVGCHFGTTTALLEQAGKYCIGVDVGSKIIKQAKNKYPDVFFAVGDAWKTASLLRIQQEYYKQEKQSHINYNNDDGPAAAAAAAAATENGTRVGFDVVFVDVGGLSGSDGLLEAILLVTSIQNALEPRCIVIKSLCMQRLSTTLVSFWELRKRMKQTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIA8</accession>
    <name>A0AAD2FIA8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000316">
        <property type="protein sequence ID" value="CAJ1933941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="414" mass="45195" checksum="FE7A28ECAC031239" modified="2024-05-29" version="1">MTKPNTSADSGFGAPLLADIFEATVTNHLKCPRPVDEPNHLMLGSLCGTTLGVSLDKGRRAFAEALFPVIMSDGLALGQKPLNGDSWKILFFPFMSECPVGFVWPATTSYAEFCDSLENRNSKVFGGLLHLLRTQKAAIQNWFDAVNANSQAFGVPVVSALPLWDTFPTIDNPNGQSLIGDCRQLAPFQVQQDRFLHNHFSQIVRRGPIAAQSKAFQMAWMQYHMFLKRGTLEYPLDQGGGGTLSAECQPFLSQMMRPMDGWNDDGPNWCANFTLDPVEVLSPFHLYPVKDIPKTAKAPPGYKPQRLVEEEPGESFDDFLAASQQLHSSEQLDNPVDSSSDTEEVAYVATLGPPPNDDGPRRVTNPTAGGPYAQMAATPRPPTRDPTTGRQTGVSWSTSPSFLAPVPAVSPPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIG5</accession>
    <name>A0AAD2FIG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS8185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1942916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1036" mass="112994" checksum="7EBEF29C9C5C74F0" modified="2024-05-29" version="1">MWQQTASLGSQSSDDKRTDSTTSTSNLEETERTPAHQQSDSCESTRVEEKSPDSALKSGPAEESLASSGNRAAAVTAFNSSIEEVETTPSHPSDADESAPIETSCRRDSLKLGSTEEVLASANSLLQHHRIERLKQRSIEIDMPYGDMPTETEIRSIYSESKKDTTPKYEQISFAASNEEPLPFFIDQVNQRGQKNSPTFRGEVEISTEEQDASFSNDEKNLSNSTRKGVTQIEDSSINAIEPKVIRSLVAKEDSKEIQNSKWYSIFGDQMNPRSSMNGGDDTAKHVDVGSSRTQMPNSIVKAIHDKPDDSVHTQMPDWIENQSSGCNDETSASTYAPGQSRTVIVHEIMREGWTWGSAWSPSGDRLAIATENHHLAVIDTRSSPIWRVKHDKRMSGSLNRGTGSIRCVAWGSNFIAIGGTGDAVSILAPTEPYPIIHTLSAGTYVGSLDWRCNSKTLITGNRDGKVHIFGIGSSEDDDSASASTEYSSGRNAIQSKILKTIDLKPAWVNAVKFSPDGLSFAVGDEDGILGVYSFLERQDGTQIEISNVANFKMEDSILDIEWSPNGKWLYSGGEDFAITIIRTDGWEAIHRIKREKWVQFLTCSSSGSHLAVGGLSSEISILDAEGTWQTAIILDLKGMNPLSAKWHPKDQFLVITGQHSNVLAIETTKSRYVQGHCFHSISPILAVEFSPDGRMAIVGNKEGVVTIFKVAGSAFSVCYEMVLDCLGTLSIKWSPNGAFIVIASESKIVVLSRRNHDESMSLGASGFAVAKIIRGIGNICGISVDPTSQFIAVCGSSPSILDATADFTKSCGINSLKNDSLPLPSSSNFSSVLEMGSSSRSLSLAASWSPDGKWLALVGRNQNLAFFDTSSDSPSKWRRLFEVKTSQAGLALAWGPPTETGLQYCAYAGEDKKVCILEIRDTERSWEMVLEVPRNGVVYDLDWDSDGLLAAAISDGTVTIMDLSYLRCGLAVNEMDYNWQRQALTCFTEIQRNKGKNCMQTLRWVPKAPGSDSLLAIGGTDGEVEILDLTAERHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIX1</accession>
    <name>A0AAD2FIX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010903">
        <property type="entry name" value="DUF1517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053023">
        <property type="entry name" value="FLAP_modulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33975">
        <property type="entry name" value="MYELIN-ASSOCIATED OLIGODENDROCYTE BASIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33975:SF2">
        <property type="entry name" value="MYELIN-ASSOCIATED OLIGODENDROCYTE BASIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07466">
        <property type="entry name" value="DUF1517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041983952" evidence="1">
        <location>
            <begin position="17"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="232" mass="25397" checksum="73B7D6B9F90D55F9" modified="2024-05-29" version="1">MFKCLISALILFSASGFVVPDVKRTSSNNFLLHIFDKLFEEEGMLGKGITVGKVQVALMSPDRSDSSIFGLLEDCATDTGNEPEELSRMANDVCLALMRKSDSWVAACSTGKWFKGDDAGKAESYYNELTNTEAMKFEKEYIPDDIDDESQGSSTIVVVSMIIEIQGDSTKFDGAGYSIAQTKEVLASIASDVLVDDGYCVNAVEVLWTPGEKDEVMSKNDMILDFPELIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJE2</accession>
    <name>A0AAD2FJE2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001202">
        <property type="protein sequence ID" value="CAJ1944104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJE2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="158" mass="18131" checksum="D58EF6671E104E1A" modified="2024-05-29" version="1">MPSVLKDIFQLGRCLMYNNPNCAIFAWNCMRDGMYYNRPSFPNALGEEGGDVQRLRVRLGIDSNTPMGFSRVTLDVYVVVKDSAYDFSMSMSTTKKPFKQTVMLSIFLDDHETEPQATMFFLVMTFHYKYLKDEHDNGNSSADLDSDMMGNAKKRQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJK3</accession>
    <name>A0AAD2FJK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="790" mass="88587" checksum="81D252C472206A7A" modified="2024-05-29" version="1">MSTTGQEDVDVVEREPTAEEIQQALTVAREQGLPEQFHVQWDETGRKFWMLKSKRFHSVPSAMAHACQIGLLPPAKMPESYQDKELSPKELEAALREARQQGLPESFTCRWDNKKRRRVWYTPDGRRVKGGIPAALKTAAELGLISNARAPTDSNKIPLTTHEKIQVGLQEARAHGLEGWNVIWDSKYNQKVFCSPDGARNLYGLDKALAYAVKQKWLPADKLPPQFAKDRELTNEEKAKAWKAAKKKNLPETWTVVWDSKQHRRVWVAPDNRRCDCISKAVVYSVKKGWLDPTIVKPQKTSLTPAEEEAALMEAKERGLPDCFSVRWNPKKNQKQWIAPQGKVCNSIPAALAYATKHELILENDNDDGPVAAMAPTKRKRKQTRIISPRPLKQAALTQLIDAALAKDVQESVPQTAHTNAATAVEEEDVVDDGDDNVVNDIDEGDIGWTKFQDDQDDDDDNDDNGVNDDIKPADSELAKETASISGAEETTGKTSMSKHEVDIAMEQAELRGLPGGWTVSWDLKRKRRMWTSPCGKYKCRGIPSALHKSMELGLISYPSTPVQDASQSVSTDARAASAMRDAKHRGLPDSWTVEFLDDGRRSLRWRSPDGRVAKTLVEALKMSVAMGILPPDKMPVEYRERTLTAEEEERSLKEAASRGLPSGWSVTWNSSRRQKIWISPDGKKKCDSINKALKVSVRLGLISQDALPARLKARDFTQEQIDAALADARAKGLTCDGEFRWRLELNTKKGCRRWISPDNKRRCDCISKAVAYSKKMGWVPADSSKSYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJU8</accession>
    <name>A0AAD2FJU8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJU8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="118" mass="13415" checksum="5D13927E7FBE579B" modified="2024-05-29" version="1">MLAILSIMSDRNTERTTTRFLCFVVAKLPSQMLVALVSFSCVGPSRFYDRFSAGFPVCRCLEGGLDVDSRVMGLVDTEDEELIKVAYDIKEGKGPDESLFYLYRCSSEKEYCIEHKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK20</accession>
    <name>A0AAD2FK20_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS5362</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000558">
        <property type="protein sequence ID" value="CAJ1936779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11046">
        <property type="entry name" value="CYP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042025167" evidence="9">
        <location>
            <begin position="21"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1936779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="602" mass="68316" checksum="AC6401F97782653F" modified="2024-05-29" version="1">MRLVAALFFTSLCIETPCAAFLNPLQHASRGRFEQALASVKPDAGVTSSSDAQGLPFWWEAVWDLDMMKAGNPGEKVKFSDIARVFKSNIEQIYGGYASLDGCPLAEGELTDIADGTMFVGLQQYMRDYGSPYKLCFGPKSFLVISDPVQARHMLRDANANYDKGVLAEILEPIMGKGLIPADPETWSVRRRQIVPAFHKAWLKYMVGLFGFCNQPLIESLDKLVKKGGKVEMEEKFCSVALDIIGKSVFNYEFGSVTDESPVVRAVYSALVEAEHRSMTPAPYWDLPFANQLVPRLRKFNADLKILNDVLDNLISRAKQTRSVEDIEELEKRNYAEVDDPSMLRFLVDMRGADIDNKQLRDDLMTMLVAGHETTAAVLTWALFELTKNPACMDKVREEIDRVVGDREPTYDDIMEMKYLRLVVAETLRLYPQPPLLIRRCRTEDNLPNGGGREATVIRGMDIFLALYNIHRDERFWPNPDEFDPMRFTRPYQNPDVPEWGGFDPKKWENKLCPTEIASDFAYLPFGGGQRKCIGDEFAVLEAVVTLSMVLRRFEFAFDESKMTNVDIADHPMNLEHPVGMRTGATIHTRRGLNMVVKRREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKB7</accession>
    <name>A0AAD2FKB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="66"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="337" mass="36531" checksum="28C02B06F8F961DA" modified="2024-05-29" version="1">MAKSSAAKDSNEASKKSPEEADHTKPDYGPWKERKRPPGSQAGRYKRFDKSIPSGAERVLVPTKNDVVFGRGKGSHDHPGNRRMREIIRRHKKDYSAIHRSKKRQIAELVYSEITQNGARFLHRKRGEEAYAVVDLNLALQKLSNTLRCRKSCLIGDEDENEETVAASSSAAFASAPGAVTIQPRRDAAGFPGAVPPAVLAPPVGGLVSAAALHQEALSAGAASMTAQDSLLRRRYLAGLARPEYMLPPTSLAAERELWMGTSSLAAERELLFRRSALGHPYGAGGAGSLLGSSLLASDPLLSAPPMSAHERYSEMMAAEQEYLLARRRLRNATLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKZ6</accession>
    <name>A0AAD2FKZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS10441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1946300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="502" mass="54586" checksum="D91BDA15F227CAF9" modified="2024-05-29" version="1">MPATDGGLGEHIVGDKVVVGKRNITVNSLLDEGGFSYVYLADSTDENGNQEPQMVLKVTSIHSRSQRDIAEKEAKLLMKLSHPSIIKIYDNCYASIAHNDVKKEGSKKERPQHLILMEYCEGGHALGVCNRLAAAGERFDLSTLVIAFGQICNAVSYLHAQRPPVVHRDLKPVNFLVKNGAYKLCDFGSAVFGHVDLKSAKAKAEQEEVIQKTTTQMFRAPEMVDLYMAKKLTQATDVWALGCCLYSLAFLKNCFEEGSNLAILSGKYTIPEDNPYGDGLVELLDRMLASDSKERADMTEVILCLSAVYSGRPLPPRKKKKNKEPSKSKAEKPIESKTTEATDEERIGTFRTDGQGVQEAVYDPTKATEGKKLASNSVAARRKRAAASGTDPKPQEAEADFGKDQDFAFAADFGGFEDKGDGFFDSPFDAGTNDANNEFEATFDTAFDSGFGDGGGGDDPFKSGTSNFDEAMGGLSMNDTESSKKSKSKDSSKKPKSKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL79</accession>
    <name>A0AAD2FL79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS10460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL79"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="299"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="649"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1946319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="77386" checksum="43C7B35DBE434255" modified="2024-05-29" version="1">MGKKSRRTKQKAPARQQNEQQVGRSPASQAQEYRVPRVEPVLLPFVTDSLVGTVLERGGVPENLNSFEALQGYLKQIFTAPVDLLPFLQALAEGLEKGPPLINRSTQLSLAIGNIMPLLHWVCQFEFLNAQYGCYFSDGMVELVLNAGGSFQSDKCTLFCCQVYLPEVCEFVAPSWCKHQPTRSFWSDLSLQCHGASETPGDLPISWVGLGPPTIDDVRETFMLLRQKGVRLAGSFSTTTLSVSIGNPTHPDIRDPIMLQKLAEDLVGLHVPKGYKFKQEDANLIEILSLEAESENDTCPICLKGVKRGVTLYCDHRFCKECILEYGKVNIACPLCQAQLCTEVSPNSRRGLYHNLLGIDEMASKRRGPRFFTNEQVIAEAKAQGIYNLSSSSESLREQLETWLSKGIQSSQQMVPLGFSAGEGPHGRLEGRGRIKLELASNTTMLTGSPPSALSMCPKFGMKNIEVSINDVPLVARISNQSLYTMFSRAIVDQLGLKRIHKLKSKKFVGFDTKKLKNKTFTCLEPVKICLQGIAVTLRNAIEVSPSPSDFMLTVQLGLDFLRSGLLSVVDVEGDMEVGDEEEGGNYFRVVGEDSWTILSQVSRESFRFYSHDGKMADLPLITFDPFMGTADRHIATISVKASTSFAQCNWCCRMFPEGMSECSNCSECFYCDERCQNAAWKIHKLNCGVSSNAETKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLK2</accession>
    <name>A0AAD2FLK2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001004">
        <property type="protein sequence ID" value="CAJ1941423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLK2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="16892" checksum="9CF0B412679A8F85" modified="2024-05-29" version="1" fragment="single">MFYLPKNDDCSPPIHYVLQALQDHPGAWEHFCRDCNVHMVAKLHNENNPMQPLNCNRMGGLATREWPCLVGFRARQWTGQILETWVKKVAQKLQSVAHIKCCYPLPLEYAGDITLPNIQVLSCYVTVQDILEALEQRIFPDMTLANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMZ7</accession>
    <name>A0AAD2FMZ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS10804</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="720"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="17">
        <location>
            <begin position="686"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="951"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1344"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1427"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1630"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1345"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1427"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1437"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1486"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1517"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1539"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1565"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1633"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1753"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1946720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1847" mass="205784" checksum="B6D0DF7EAA695EB7" modified="2024-05-29" version="1">MFYYSIDGSNNNRNNPSWGQKETPRVRYLPQASRYYDETAPNTGGGIPVDETNSNLPSARRIMEAIFSQSTPHADKGTNHLMLEFGHFIVQDVIGRTLLNETEPFPMPCDGEVTDVVFCPVTGQTYSIPFDRSQHATFANRNIPRASLNGETAFMDMSNLYGNTPEVQEEVREFVGGRVKLDEMGLPPILNKYNSSPGVFAMYCVFLRYHNILAAEFQEKNPTLKEEELFQMARQKNIAIYQFNAEEKYIPTLLGSKLEPYVGYNSSVDPSIDEFFAAASFRYAHSSFSGLVRLLDENFDPTGSDPLILRDVFRQSSPNNVPRVVRNHGGIEPFLRGLTVTNAKAVDASLVHDMNYFTEATSLLDVQRGRDMGLPSYNDAREAFGLERVKDFESLVGYDYQGILAPLKELYNDDIEKLDAYVGALLEAKDTGAEMGPLFSQSILNQFQRIRDGDRLWYRNNQYTQEEWEQFPSMADLIRATCTGMDNLPTESFLAWDGVAGEGAATCGASATQLSLINGKYSLGWQIDVPSAADLRDQPDMKSTIEVTMNFNERMNNPGFLGVGWRSQQMRGAEIWWCTANADIFATETFPDACDANSDKVNFEKKLFSCCVADGGLHVQPVCSSPDASVYYELTIVDWCLTPGTSRVTVTAPVCDDNEQFTNGKVNCFRKTSSANGEMDFIVAYNPNRIGNHGYQMRTAAAVDLSVGVLTQSESDTADVGLIATHAIFMLFGWMVLAPMAIFIVRYMKTKEWRLVAHVSLMGIVGSMMVPLLIGVEASVGATDKTEEHSFVGLSLLGVYFVMVFAGRVRYLKLQGKKVGRKTYFFSAILHKYGGVVMVLLAWWNCYTGLVRIGPEDSYFQVLLLSMGYDLDIFGSIRKYIYFPYLAVVCLAFIFAEAQRYRLNSSSHVSKLQGILEGKNTIWEDDADKFLEKMTMDAFMEATKLGTMLCIVDGYVLDITSFVESHPGGQHLLRYAAGSDITEEFVGKRDVDGLRNVHSHSAVELMKTFVKAVLVDENNQKLSFQKGASSRMALSKSKNGKGFGRMSLMETIARVPQTRRGASVFRRGRVVGLRYLTPEIEITHTSKPAILLQLALPKTRKDLHVQKLISLPSCAFTFRGIDKYNSAVDRQYTPVKIHNDFASRTKDDTDEDIFDFVISLVPGGKMTKIFLDLRVGKVLLAKGPTVNQETVATFRTGEWRSVVMVAAGTGVSPMLQVIDYYIGKLSSEFKGLESVLDAEVPNLYLMWIVKSPKYNYAETLALDSRVARSNGKFKYTVIYSTSHGKESIEKPRHQLHHQWTFKEVVDKTTPRRIGLPGFKKPQKVKRAVVDAAWKSKKNLSKKTDLSSLAAPTNKTIRSSESSSDEFSIENEITTATWRDDKVQTCYRSYNRMLLEELLLSIPETDGSFRTSSNPTMGRISLPSIIEEGSEEDESSDDDHSSSYDQDDRNSVDRDSSYGSYSSYDEGSRSSKGDSSSFKDSFKDEGSISQESRSESSSSSSSGLRSGLKFIPSLSSDKGSHGTHESAKSPDNCSLDEKEESSSHGTRETPKNPDNGSLDEKEESGTVATERSGSSPESNQQADLESNLLTSWVPSRPLDRSSWMPPTGLDAAKNASYDSDYVSFDHNQLKRGFSTANSGSAILRSPTSKTNQRNLIPPRLGGPPLEHEPFHKVPPRLGSPPPEKEPSRSIPPLVPKSIAAPSTEQSSSQPKASEPPPKSSAVPFARNIPVVQNKPPKRNQPARVPSLENTPQSPKKDAVDEDHKERSSLEERTPSKNLETAHSDSRRETREEELLDQWEIDEEEYRDRKILVAISGAPMFEYKTRMNLGDLGFPQENIVTFHASGQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP26</accession>
    <name>A0AAD2FP26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS11358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042174533" evidence="4">
        <location>
            <begin position="27"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1947887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="723" mass="77976" checksum="B498F3C7C77A1B16" modified="2024-05-29" version="1">MRTKTNTTLMMVPIMMLILSTIEVTASSSSTAHSNTFIRHHHHHPMFHPKPDLHRNLGTRGNRLQWGDDDATYADYNPDYSGEKDEDGNPIVSVIADGETSQQQQTASPTSDTETITDENGNIIFNGSSCKPGNKRPCSPSAQPSAVPSPAPTEPTTPRPSLLLTFPPTKSPTPLPTKNPTPPPSLLLTFPPTKSPTQLPTSPPTWILTRSPTKGPTLPPTFPPTRMASSSPTVGPTKSPTPNPTRAPTTPPTPGPTRAPTPNPTPVPTLPPTPGPTREPSPFPTPHPTKFPTPSPTVEASISPTKLPSLAPSMVPTMAIQTQTGINGTRVTECSSPPLGQGISNVQLLAFKYNLYLPVLVTLPPTTTTVQADSVSSIADGTNRFQDAAAILEQRIHNGLVAQFLTCNGEVDENEAVIAENGFRVTAVMSAPTDQVNMTSVCDTTNDPVTDTPTECFEVVAQLAMDAFFPTTRRRRRVLLLRRLQLTLADPQFLDSVGDYLNTSMANDEFIGTRDGDDDNVPVEDRAVQVSFQGFLNVLNQDDDDGTTSGSGVSNADGIVGAGSPGGSSSDKDRHVFLLGTAAFGGVSLLLFLVALFATRRNRNRQETYLRQLDDLAASDRDSEVSSQASHILADGRVHLVRDEEYDRFEAEEMEIEMELPASHSDVHFCSSATCPICKHRTSGPITFVSSALSQKDLEDLSPRKRSHRPNGRRYQAPDTVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP41</accession>
    <name>A0AAD2FP41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS11388</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18131">
        <property type="entry name" value="ASADH_C_bac_euk_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02316">
        <property type="entry name" value="VcASADH2_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011456">
        <property type="entry name" value="PRK14874.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46278:SF2">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46278">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041897079" description="aspartate-semialdehyde dehydrogenase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="49"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1947947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="386" mass="41723" checksum="53F28209625B08CB" modified="2024-05-29" version="1">MKFSLSAVVSVMAVSSCAAFTPIQKTHTTTLRPTTTRGSSSSTTSLNYSVGIVGATGAVGKEIRQCLETRGVLDVDTLRIFGSERSAGSTVETKYGDISVELFSEEACRECDVVFLAVDGDFALKHARNICEGDDGAVVIDNSSAFRYEDDVPLVVPEINGKETKKSKLIANPNCTTAIGLMALWPLIQKFGVVKVLMSTYQASSGAGQPGMDELTSGTKAYLEGKEVVNKIFAHPLPFNVIPQIDKFQENGYTKEEMKVTWECRKICNLPEDTPISCTAVRIPTIRAHSETIVLETEKDVDVAVARQVLEEAKGVKVVDDPESLSYPMPLTATGQYDVEVGRIRKSIAFGDKGLEFFVCGDQLLRGAALNAVLVAEEMQENGALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPI6</accession>
    <name>A0AAD2FPI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042084139" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="50"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="376" mass="42506" checksum="BF1205049DAB94CE" modified="2024-05-29" version="1">MLRLPLFNILLLLNILGHGAFGEESAFIRHSQEVHNLIQWLESAGGFLDSRVEIRRLDPEDPSSYFGVFANAPIQENEILMRIPGELKIQIVDDGNDWEYDEEVCELSWMLKAEFEKGDKSKFLPYINYLRTQVEGQIPGAWSSAGQGLLLKVQGGLRINGAYEEEEPSSIVSWLRSYAEEECAVGDETLDPHFIALTVQRGYDSALIPIYDMLNHSNHPEKVNTMTDSSLHDFDDEFTVQALRHLKAGEELHYAYHDTSSDEWGTPEILRDFGFVEGYPHTFHISDGVTIVVDQVESDDGQLEYVASCLNENCPESSWIEEKVQALMEVEEILLPEVAMAKLQVPPRELAIIKEYHQALLVAFSSISSKCPDPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPR1</accession>
    <name>A0AAD2FPR1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001757">
        <property type="protein sequence ID" value="CAJ1948817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPR1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="126" mass="13919" checksum="7574EC8676F03FAB" modified="2024-05-29" version="1">MYYLNGTKGMHLTLSAKDLRTFKWYIDASFPVHPDFRSHTGGVLTMGEGGLQIISKKQKLNSQSSTEAKLIGVDDAATQILWTKLFVEAQGYPGEENIPYLDNKSSILSEENGHDSAGKQSRALNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQN1</accession>
    <name>A0AAD2FQN1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1949634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="369" mass="41152" checksum="263D28D48BFA3844" modified="2024-05-29" version="1">MVDSSSHRFFYYSYPPCGECEHVHFPVRDLAAAWDATKVLDFSFSAQTDCGFHNLPALQFRLADAIRTTVDFYSESPTPVVVSKQDGVTCLNEDVLREDATIGHSALVLLAWSGACRLGIFLPNEPPMPIDSLTKGILAMQLETGAFGCTFKNPTEYLRGIAFFPGEAMLALMDVYELSRDTKTRHSLDAMVQDSILSAMEQAFKFYSRHHEENELDVNYNIWQAQAFARYYNALSDSSAHKDAVATYVLDLCHEVCESRSWKYQLARGSSFYVNLETVEIVCGLDALVEGLTVAQALQDDHAVTKFRIHVTNAARFVEWVQDQVPEDSLVGHGGLGYGGIQVLEQRLDVTGHGLSAMNKLHKLAMKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRL9</accession>
    <name>A0AAD2FRL9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRL9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1949835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="421" mass="47333" checksum="86BB895F66D20920" modified="2024-05-29" version="1">MLKASYSLNSYGRTVFALCIVLCFTHSVSSTHAHQRKAASLISPIGDPIDVWDSVDTWKRCSIVDVPDIPSRVYAEAKDKMHMIEGSTHFFPMTGDSIFNFTRSCKPAWNMTGDGNPAMFAGNEFLDSAIAFSNGTVVSLIHTEFPGNRYNMCNSTAYPLCWTVTIGLAISHDWGATWSHVRPPPHHLMAAVPYVYDEKKLAYGWGDPSNIVLNPRDGYYYVAMWNRHQIGKQKSGICIARTRQLLDPSSWRGWDGKGFSTTFVSPYSLDPKAPKEQHICTVIENVPTLCAALSMVWSTYLEKFVMTIGCFDELSKSFYISTSDDLIHWTTMRPFFDADILPPRVKKMITSIGYPALLDPIAFSSYGDRNFYTIGKEPYLFWVSLGHSPYTDGRHLWASPMRFNSEEGVLSNVSSSYTTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRV5</accession>
    <name>A0AAD2FRV5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRV5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="194" mass="22806" checksum="1DE8103FFAF5B89C" modified="2024-05-29" version="1">MKVDWKTSEARKIVLNDLGSGFLALNPKDISAREAWGTLYEYMDEFEGIEFNQFSRNLSSYRKKMASDSKFVWNNTCAQDIVLKDLETGRLPAYQREMSSEEAWRSLYSTRKEFKNVPFWHFEERLRELRSKKQMQLRSDFEHICLLKDMSRIARKIGKEGMKPNPGTILADILTEYPGLAEWDGDAKHLYQCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS37</accession>
    <name>A0AAD2FS37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001765">
        <property type="protein sequence ID" value="CAJ1950393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="250" mass="29206" checksum="438B84179F40012E" modified="2024-05-29" version="1">MPGRRNQGRGGRGGRGGRSAQQTGRGSHGKKADRPKQYHPHNPDFTHEQVTIYLLEAIALKSLDYAQDMIWSMRNMAHVDFEALRGTQTVYKPGKNDSEFFKSSRQAQLDRNWENLNVKIDKREVIYTTNQYTVAAIITKHFITQAMRDKLSNESDWLDLKEDHVMLLKRIKTFMTITDKTEWQHFGLMESLKRFMNCTQKQNESVNDYRRRFEAQADQVFEILGTDVLHVYATKTMGYLDLDDKFLQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT16</accession>
    <name>A0AAD2FT16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS13481</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="129"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="251"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1952296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="338" mass="37645" checksum="DE8DC020C5A8E3F5" modified="2024-05-29" version="1">MNDSVREVVSGAFAGASTKTLLAPLDRLKLVVQLRGSIPPSANNNNVASNHYQGPVQAMTKILREEGFFALWRGNTSTVVIQGGTTALNFLFLDWYKKTADHLVLGNRGSTAGGEQTYSSSSVSLTRQERIAKSFVSGFLAGGSAITLLYPIGLMRTKLALDVGQETRLYPRGMRDVFLHSYQVNGLTSLYQGFAVALWSVSIYRMVYLGGYDYLKTELVEDYKAKYSNATTTSTTTLTDEDAYRAIPFYQRFLSAQLVSMLASTAHYPLDSVRRRLMMQSDMPKEKRLYKNARHCLVKIYQDEGIAGYYRGLGTNYIRSVGAALLLVSYDYCKELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTY2</accession>
    <name>A0AAD2FTY2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001820">
        <property type="protein sequence ID" value="CAJ1953145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTY2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041971514" evidence="1">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="103" mass="11605" checksum="053B63654D50868D" modified="2024-05-29" version="1">MLVKMKTCLILLLKQIKVCSLFKAAERKEIHLGCMIMSSWTVGSRVLDEEGFLGRFPPPVYHDEDGIANVLAMREMIAVGYRITMDTDADNAFIVHCDGKQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVA8</accession>
    <name>A0AAD2FVA8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS14592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the centrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1953994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="152" mass="17283" checksum="088248F0875926E5" modified="2024-05-29" version="1">MSLPENEVAELKEHFELYDLHSAGFISVRELGWAVRGYGVNVTESSLKHAVEKYDNGKGQIMFSDYVDFMARKMTDPGLNEEDIMDSFSVFDKDKKGKVNVKELKDVMCKMGEPMTGAEIEGVLKDAEIDADGNMNYKDFVKRLNDMYELFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVI8</accession>
    <name>A0AAD2FVI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SOUL heme-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF58">
        <property type="entry name" value="SOUL HEME-BINDING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41474" checksum="84B02B839FD5B5C2" modified="2024-05-29" version="1">MNKVLSREVSTVRLSFEGGESPSNPVANDNAVERLTQAINSNATAAEALLSKISMMRENAVSQETMEAYLNKLLAAGPDKRLPFWARSKRLARFSRRARMASLRRTLDLTTPAPEAEEETVERKLGRRRRALVALLRSISTEEGLDSKEPVIVTIENRARLASKESNEDMKSRMPEGLETPNYDIVATSKHNGQTIEIRRYKPFSVCAVNMNKPRPDAAKETDNKVRVPEISGASSFGALAGYLFGKNDQSTAMKMTTPVFTSPIEQGDKQMEFVLPSSYWDDDSLGTAPKPLSGSGVSLQQRVSQDRAVLMFGGYASKKEVAKRKRELMAALKKDKQWKAEEDEATTAQYNDPFTVPWRRLNEVSIKVVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW76</accession>
    <name>A0AAD2FW76_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001840">
        <property type="protein sequence ID" value="CAJ1953786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW76"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="245" mass="27695" checksum="873D05604BBDC356" modified="2024-05-29" version="1">MPGFKPDGGSEEDTAAMEEEKNKTEKKKGSFGMLWEATLLADFQEFVSKILFAHYSAPESKLSNQQIKSQTCPSKLPPQVSQEGLRNYIHSHLNDNLDPSFQTEDNGESVNFEHDDDHEEELAELSIESEARNNPNGSFVMDLDVGSQYGANYLPNDITLPTINFEVDDPHVTGPNGENIPLPHPINPFKFRPDPQDKPDLVETTVTILVDKRNIQQLSRPRATPFLFYLMDLPQRWPDKSVVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWA9</accession>
    <name>A0AAD2FWA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS15391</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWA9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="17">
        <location>
            <begin position="21"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="481"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1954799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="519" mass="56892" checksum="67A4F1849B6AEA8B" modified="2024-05-29" version="1">MKVLDTPKTADLRNDSFINKLAIVASMSGLLFGYDTGVVSGAIVYMRVQMDLSPFQVEVVVSSTILAAAFSSFWGHHIMDKYGRKFTLMVASSIFIVGSIIMGASFGPYHKGLTMMVIGRITVGIAIGLASEAGPLYISECAPPPLRGKLTTLFNIAVVGGQVFAAILCGALSYLPWSYNWRLMLAFGAFPALGQLLGFLSLPISPAWLVLQGKEEEAEIVLRQIRMIPVQQNEDGEIIPDPVQKELKEIVDEFEESKKKQHVSLFRLWTAYPSIRRAMILGCSLWAVSQLAGINTIMYYGASIVRKAGLGGDRSFDIWITVPLYFMQLVGIIICYNIIDRWGRRPTLLFSMTLVLIGLLTIGTGFATDNGILTIIGMVCYLFAFGVGLSTMPYTMNAEIYPTEYRGVCVAQSTGVFWATNFVVSLTFLTLARVLGNAGVFFLYAGIVFVSEIYFYFVVPETSGLSLHEIQAIFEQKPEESVGLSDTSTDGIETTEYGSTDVSPDVSSSPAERKLPMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYC4</accession>
    <name>A0AAD2FYC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001917">
        <property type="protein sequence ID" value="CAJ1956589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="333" mass="35259" checksum="0183C0EBD42F3A72" modified="2024-05-29" version="1">MKKSANAEYDFLDFWEANQKFFAMKQGTTKNLIHFKEQFLRQAEVLQDLYGVAWFQKFAVKTKEYAAIASTDTAAQDKFKDAIFEAEKTNLIKVKVKVKVKVKVKVKAKAKVKAKAKAKAKAKAKAKAKATKATKATKATKATKATKATKATKATKATKATKATKATKATKAKATKAAKAAKAAKAAKAAKAAKAKAKANQRQTKGKPKANQRQTKGKPKDGKKKAAYTVQAIVPGASASTSGALTVVGSVTITPLRLAGTTGNQMMQVPAGMQLMQIPTQGGGTVTVPYSMNANGEIAFSGMQLGHQGFSGAQVRQGFDGTQARTPQVVKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYE2</accession>
    <name>A0AAD2FYE2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001918">
        <property type="protein sequence ID" value="CAJ1956610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYE2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="305" mass="33645" checksum="14180D62D0776908" modified="2024-05-29" version="1">MQRFPPGQSVEVELESQPFKDQSNEHEQWSNANGPIYKACLQDTKIRASKRALIAWWQASGKNAYRKALNSKRQTLSNTLKGLVIGMFMNPERVQPPEPSMVYSVGAEGNIAGLRENTDIYILFLKNFMRAIYGQKFTALSMKKTISGFVPECLEAFLVLAYDNGYDAWKAEAEKKLAEAEASGGIGTNNGNESPDARGLEGDSDSPGSDSSESHVPLAAQECRIVGDFKFTGSGQGSRKAEGWSEEGYTLFNKLFSRIKEQRADETLGLQFETTFIFNAEEVAPAPADQVVIQNNWADLAVYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYN0</accession>
    <name>A0AAD2FYN0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="22239" checksum="C48A6B15A1C25A3C" modified="2024-05-29" version="1">MVPQIRESIHYQHDEEPVWLSVFGSERKSVSKELRSDFHPPSYIIVQQKRVLFDDNLDIFCVDRVSGKYHDKVWYSEAELASFEERYIAKAGKKRSLRERDARAYNHSRRVLLHHRAYKEMGDYNKANDLEYFSSQSSQSCKDMCRKQAKRLEKEVRSIQSESDEQTTSSSTGLEYFIEKVFSFSSQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G117</accession>
    <name>A0AAD2G117_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002000">
        <property type="protein sequence ID" value="CAJ1959461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G117"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33113" checksum="1D5863C5A1AC350F" modified="2024-05-29" version="1">MTRQDKRDRIEMEQKAVGVMLKQKEYKEDLIADPRKGKRGKKKPVASLEEFLRSLPASDFFGDDHRCHLSASARLVFQNVNGLLASSTGWKQLQINQWLKEEQVGIALLAETNTHWPSLPEGQNWNDRMRQVGSKGYYFTTAHNKNRARPIASCSQYGGCVATVLNSVAHQAKSFGRDPSKLGRWSYVRLRGKKFAMPSSDNQVNEAADASQSQFSKDLVVVAVYRPNPPGKGESTVWAQHRSFFCSQGRQRDPREAFMVDLLQAITQWHDKGCKVIVGVDANARIPLFASAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G195</accession>
    <name>A0AAD2G195_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS1520</name>
        <name evidence="7" type="ORF">CYCCA115_LOCUS18017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000058">
        <property type="protein sequence ID" value="CAJ1928653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002007">
        <property type="protein sequence ID" value="CAJ1959596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G195"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="131"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1928653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1959596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="39639" checksum="25D98295CB94FFF3" modified="2024-05-29" version="1">MTSKLPPPSVWINSKCCTFGASVFDSILSTSSRNSLREDISSTDDDSSANHYDRTLVSLNQGYDNGQLTLLSASSLSDGNGSKGVLRIPFGRSRSYPPLGSHPCPTTVSETQAATQAKLLSQGSGPNVRRFVQLAVVGLVVSPQNEILITRRPSYMRSFPHAWVFPGGSVDSTDDSLEAAIAREIWEETGLKVSGSSLSAMQALDASAGDGEKTTTSCSGWTIECIWESVFPTIPEPGITIKRHHLVVYLSIKLSEREMSQMSLKLCDEEVDAAVWLSPKKVNSILAKGLCRADSSVSEEEIWVDLLTSSNTQVAAKTGVKESLEHLSGIYPRFDDDDTSSQHPFGMAQGSLFALQEYCNRHHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1S7</accession>
    <name>A0AAD2G1S7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1S7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114290" checksum="8BF869ED90E4B353" modified="2024-05-29" version="1">MTKTSWELLDPITVLPDGGMPAMDGIVAFLDHPENPTKVGVRLTGSSIGLGDHSGSVDGIDYFECPLNSGLFCTPDQLEVRTLSRIEQLRLKRELAAGQLDMSKGGSMMMAAAGYGDSNISSKQVIRSSMIGHGGLPPSITNHHQAIVPQQDQPQSISLNGLSPTALARLQQINPGYMDPNVTPVSSSTAPAAPAAAADDPPLTVPEEDDEDDEMLVSDHEDEEGENYDDAAEEEYLQINRQHISRLQQRKEEIKQRKLELQKGKARGDNSNGESSNNEAAPPPLTDEGQTAAVVTPSKRGGGETTTTTTATTTTTSNDTSMEESSSSEPPLSRLEQLKLKKRQLETTPATATTPTSATTTQSSTVNSIVSMAAAATAQEQAAAPGEEASEQVPWPFPATSREVPPNTTTIVPGAESQQAQPVPVPALATATEEPLSRLELLKLKKRQLEEAGPPAAPAPKAPKTTTLDSTARTSPRPVAVAASPISPTPPTATLILPASMSMDRGAPPPVINRGGVRSQPPKPKPAELSVQIMNSSTKRFKEVPLKISNDINLYSAVYDHQSVKQANVRKWGTSFVQQVKEKKSEIRCRVLLLSNPPPELANEPNKSMPMELSVDQLKVTTTELLWNQYKDNFHAGRSKVQMLLRCQPINGNGQEKEEEEVQDSSNKKLFTDQEEEEEGEPTAAEDSAPAPKEEEREIQIPAHFDRSSITSIASQLGDVKHQLRIKVINERTRYFKDLLVETSPQINLYEAIYNNPAVKEAKVRKWNSSIVEQVRSGMAEIVCQICTIPNGKPEHLVKHGALTIEQLKECSTTELYTRYAMDHYDLENDQSLIQLVLKCQQTKTPVASNQASKPKPQGPLVTPTKLADSLPPVTPQAEASRGNPATETAPIVSQQTHPRTSPTEASQSSLSSMERKPTNSPYAKAASAALPMHNTQTTFSDLLRHEQQQQQAILSPNSVVMTPDRDPELGLGRIAEPIETKVDAGVQTAIEMTTPVRDNRHPSPQQRMQQQRPMTFAEKLQEVDPYWWLAIIFILAAAFFAALFLGPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2H9</accession>
    <name>A0AAD2G2H9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS18490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002046">
        <property type="protein sequence ID" value="CAJ1960074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2H9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="163"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="341"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1960074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="493" mass="53988" checksum="D907E5AA1E3E7054" modified="2024-05-29" version="1">MNTSFTDSNKSVRSNVCPRWERKRQNARDRAPLSSKNGGDRFIPNRAGMNMELSKHIFRGDTEDMTMSDGPEGETQSHLPSNQQVVPDANKQEYQSRLSAALLGVDDKSNNRIMSFKDKAPQPKGDTVNNLNVLYSAARSGPQKKSNAKLASRPIPSAPSRVLDAPDLMDDYYLNLISWSDTNILAVALANTVYLWNAGTGDIHELCTYDDGPSSHISSVAWVQEGGAHLAVGTSGGKTQLWDVHACKQLRSMDGHTDRVGSMAWNRHILSTGSRDTNIVNHDVRVSKHNVATLSAHCQEVCGLTWSNDGEVLASGGNDNLLCLWDATQTSLNNPGPRFQLTDHQAAVKALAWSPHERHLLATGGGTADRCIKFWNSQTGACLNSIDTGSQVCALQWSPFEKEILSSHGFARNQLCLWKYPSMGKIKELEGHTSRVLHMCVSPDGSTIVSAAGDETLRFWEIFAAPSKKHQSSSHYSASGNSSSKLSWTSQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2J7</accession>
    <name>A0AAD2G2J7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2J7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="137" mass="15913" checksum="F0C20DC54F0B7C96" modified="2024-05-29" version="1">MEGRRSRRLGYEIEEYKAKHNTVPIPHLMFDVYIRLGEAEEMMENWEAAKLMYFGMTMETDDGATSTPPQQLKMFTGLCRVAYHLKSQKAMGDMDASKVTMARALVYEAPWDDHHHEQVLHLYREIVGEEPETRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G306</accession>
    <name>A0AAD2G306_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS18870</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G306"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF57">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1960740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="17549" checksum="372A64BB2012683D" modified="2024-05-29" version="1">MPSNSKFPLGIMLMAAPYCVVNGYLQAQDLSQFRMYHQGHIMSLNFIVGTVVTLCGFGIAYQSDSTLVQLKKSTGTYQIPKGGMFQFVSCPHFFGEILEWTGFCIASNGSLATLSFVIWTACNLIPRALAQHQWYHSKFPEEYKQLRRKAVIPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G311</accession>
    <name>A0AAD2G311_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G311"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="87" mass="9888" checksum="F3E75B55414CCBBC" modified="2024-05-29" version="1">MTQSNNNLKQASPNRRPMSLKSSVLQNMMPSSDLLPRRAPPKNDSPQERSAFVIGILDEVLDILNDDIFDDEDDLVFDTKSNRRLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4Q5</accession>
    <name>A0AAD2G4Q5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4Q5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1126" mass="127867" checksum="76B431E2FD5721BE" modified="2024-05-29" version="1">MDDSSSSFDESIISDGGELKIDDNDQRLSLNSLDCAGESEMFEAPLVSKSGHHRASPTDYKKAARRYAKRVSSLTSELRNRLVNHSDDLRNNENIMALTINKLQPDSVGLVGREEEIKLLQSCLSRMTNANDDNDNNSDADEFASSSSRQKELIFIQGYSGVGKSTLAYTLDKEVTDMQHGIFLRGKFDFSSDEPYAGIAKVFGELFLTIQIRQQEDKGGELIRSIGETIISELGSEVKLLSTLVPEFDNIVPPPDDGDSYDVQNFDWDAEHERWKYVFRVLTRVMNAFFSPMVMVFDDLQWVDAGSLEVLQYLVSDMRNSNALMIIGCYRSNEVNEKHMLSQAIYDLSTKQQRYGFNMTNINLHSFELNEVKQIVTSILSIDNERRAQKLSEICFKRTNGNPYFLIEFVTMLEEEGLITFSLGLMVWTWDSEKVEKETMSTSNVVHLLQARMEKLSRSYQLLLQYIACLGSTFPINTVDIIWNQHARRDSGHLKAQDVSAMLAVLAEKDFIEQCGQKSYRWVHDRVQEAALLLGDARGSAFQYEVGLVLFECLDGEELDENVFAVANLINKGKVQRSDFAALNLHAAEKAQGIAAFHSASKYVSAGLDTLPKDKWESQRDLTLRLYTIGTETELALGRVEKMKKYSKEVLSQESCSTLDKVPVYTASFHKLSNIDMKYKDTIQFCLTVLEELGVDLAAKGPLHTTKTITIFRRTVRNAKNTPISTFESPTMMEDPKQEATMQFLFRLLYASYLSKNNLLLIQSTTRMIQITLEHGVSMLAGPAYAHLGLVTVALLHDYQTAAFFAETALAIQDLDKGDHFEANTLFSCYNHVLPWTKHLENCFAPFANAYTSGMRTGNSEYAMWASIMRRIFLSFHLGKPLGRILAKCATCATQTEELKQHDQDTFLRMFWQVILNLTGNSNSTKTLHGEAYNSVKFVRKTPLHDALHNLAKLELLLFFGDYAGAADLSVECDESFSKAFPGFFLCMMETFHRGIALFAMARKTKQGKYKRRARQILKTVGIWRDKGNPNVEHYWIFLKAEDEALRRKYDSAKKLFVESIRLAARNGNLHHAALINERYGDFVKEDLNDDEEYNYRLHEAIRFYREWGASAKVDLLMKTTSSLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G571</accession>
    <name>A0AAD2G571_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002118">
        <property type="protein sequence ID" value="CAJ1962771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G571"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="184" mass="21071" checksum="AE0026E44C1EB804" modified="2024-05-29" version="1">MIIKPTGKLNLDLFVDADFCGLYNTEPHTDPKSVRSRTGFIVKLSNCPLIWRSQLQTSITCSTLEAEYNALSSAVKTLIPLKRLLIEATDHVELDNGIRATIRASAFEDNQGAYFLATNQRITSRTRWYLNKWHWFWQHVTKDGVGPETVAIHELDTSLQDADYFTKAQSCEPFESNRFRVQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5Q4</accession>
    <name>A0AAD2G5Q4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002134">
        <property type="protein sequence ID" value="CAJ1963143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5Q4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="215" mass="23273" checksum="442D49A12F575940" modified="2024-05-29" version="1" fragment="single">ELAHDEWKISELWTWFQWKKCWTKQIAARQGIDEAIDFLDGFGSDPLDVAEAKLEFDMEMADAKDIDDGATVAGAMDELLEKDSQLEAAITEIEFKENLLVEKSSALEAERLWSESLANELAALCLLQQTISSQEAQPALPPQPTATVSFPQDRSESAAADSAAKEPTLPATPARAAKSSPLTASLPSSPPRATTAIANQLRLETPPLLLLGGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6I6</accession>
    <name>A0AAD2G6I6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6I6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="935" mass="104653" checksum="18CF2C134EA9EE35" modified="2024-05-29" version="1">MLRQNNSNASTSSQSTGGDITKNNHQQREQEEHQKKKGSRGISPFSLRSRGTSPSDGKPRGISPFGKKNRNQVVRKQSSSDSSSSLGSSSHHHHHHHQESKEDIVVCHGSARSIVFRDQLRLAAKIIQEETDQDMLMMSDDDDDNGSNHSGNEADAGFESMQAAMRDSIRVSIRESDGGNKVTNEINSLAHNMVPELKDVTLRVQDVSERNVEIEGQQVHLKPLPKLELGPTQTFDALENDKTTDMDKSDWNMAEQDVYQLLKKQQACVKTIKNSEWPSFLQRFQVAKNKEQKCRFPTQHEDIPPNHQEGYPFNSFVTSTTLLPELGKKMRCYGSLYSYPVGVVFALPNSDSPNEEDDAAAQAKTWSWPAGYAAKTEFNIERGKLINGRQEALVSLTQLRQYNKEYVYEKDHYIGGRLVKGGFQVVPYNEVFLRVGGRGRIVQGMDTVTREARNDVKGTGRSFGTGMGLPVALFIRSCTIGDILTLLRTKARVEHVLGDQYIHGIPLLVITPDCGVRVFSERLQHAFWKLAAHRVNPFQNPILEPSLKVDDPNQNYLHQKALEQISFLDDDYEDDGNAEWVSSYLTIEECARLAGGFGATDEFLAKLLEKAREQDLLEDSDEENLKSPRSSHRRRNRHDSLNNVMSTALNAALRSNDYYTARQLLIVYSIVSTGHYHDRFEHNHQGSKQKGPNNEISDQGGNDTGAEDPTSLEFAYRVSETATNSALPVSKQHEKVPDEAAEQKEEKSFSPQFTPVLPSLDTWRLRNATNSQGILFVLGAVEILSAARSGSAQSRAKESIVALDEWVQYGEESVAFRIASWSKQRATEHDTHVALEGSSQFMAFVSNKAITNRKGFAKKLQSALEAEKGADAVASSEESHLCFLKRIQEIVNSLHAPCLRLEILQYILGLDNRFSVDHIRHSMELAVTCMVLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6P4</accession>
    <name>A0AAD2G6P4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6P4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="19828" checksum="5EA0099F35A0304B" modified="2024-05-29" version="1">MTDACISENDVLCGRGGATNTHIGNKRFRAIVAEYQEVYLGARKKEKAQIASRVVERIRQNGGRFLKRDTTTDTWVEVPSKKALGKTGQALREGLDVRHNTIRPDKMPRKYSEAKSNSPRIRARLVQGKVAMSPTLSSVATEQSIPSLEEEQAFDGVSMYFAPQQITQENIEVYEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G738</accession>
    <name>A0AAD2G738_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1962046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G738"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="669" mass="75313" checksum="93CB070AA1D2033A" modified="2024-05-29" version="1">MPKPSSPFSVSPRRHLIPSFVWTTVLKPPRKEKNASANPRDNTEDDTKLTTLQNDQNSLHSNNSSSGYNDDDEKDISDNIEDMEELLEMNFTLEDSQYHDLWNATTASVAEVEKDINTSSPLASSSPLASSSPFKGIDFSVYSNNFPAFSFDSWKNYSSTYSSSKSGFTKGFYNPYGHNYSDSSSSSRSSNHYKSKGSSKSENLTLPPLLEGKVQPNDTLTLSDLQEILQYNGYVRKDDLGGGGGIFGGGGLAFRDKRKVPSSFEDDDNYDSLVVSSDPKRRRTEKGVAFPQPSILSYRALRRATTLVSATYGILIATTIFPNLWLLGLALGSFYGYGISNFSGDEDASPPKGVVPNFCLESGRKLAKGTLDLYDKWQGVWFLYKTGQLSYEYYKQYEALDKRFAIQDKMDAWNARFQEGKIKFDNWEKQNEVGRTMLAGLRTVWLVDEQAKRRRANKQKTSRYRAVQYFYNLQFYIGRGWKRLVTMILNSNSKFWGEFVSGIRQDMKFSGMDALGTRIGAVVASLLVIYATGALFAISPLVLGVLAILLGVVWPSWVAELAERMQDIFDETRARGRGDDEYVPSRASSMNMARVLGRYDKKKYHYYKRPDGSKRYYRTGQSYFRFGTSENNDLRQAMPWNTNPPTKKKDPPTNTWGIFGSFAKGGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8Z3</accession>
    <name>A0AAD2G8Z3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA 5'-phosphatase</fullName>
            <ecNumber evidence="3">3.6.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS22033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8Z3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="8">
        <location>
            <begin position="74"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="7">
        <location>
            <begin position="407"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1966450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="764" mass="85695" checksum="BE40A13C6C4D3818" modified="2024-05-29" version="1">MSKRMGGNLASLMDKRNKLEKDTAQTKSSAALNKNKNPFLSKPIQPGQTLQMFLVQARRSALNYEPTKPPFTKPFCEIEARIGVLKINDRRVTSSGPKRINNALVQAFDCTSLQQKPSMESGVSRSHYVHWTQAGLSEASPISAALGVMVKPNMPNKEVVAMIKRDLVEKELVETVFAGYPGDRRVAFPCIVPLNGKLPDSTTVGAMEYKEKLVQMEWAIPAAKYDFRVALASEKTVDKSVKSVPDGWSIQRIKRRRSYTRRDGNIAWQIDVTEITSTPRDSPHKKTVLFEIEMELRAENMLKLLNAESTEKASGLAKAYSQQLWWILGQINPLEDTVDVEEYLQPHPNKKAVQLALATCGALKRFMERPPAPGSKAQPVHMDAPISKPNEAPSPALSNVKFCGCMPVNFARHNIDEIQQSAKNAYFLSEKTDGVRHFMIFTGDTVVLVDRAMKGKQAIPTKPGQEPMASVLPLIKPGTVFDGEVVMHRGGSGHKARPIFIVFDVLTVGASAAILHLPFEQRLYHLKQSSFRTDTADRNMFATSLSDPSIPMPLVRKNFVQRSELATLLGHVIEEKGTRSYRNPPLHNHLTDGIIFQPNLPYACGTDLNLLKWKYLDTVTIDVELLPMRQNYHGGGDEDELNVGVMGNEQTTVDMTRHVNLPKSERLRLEADKFESGSRIAEVGFDPETGEWYYLTMRPDKIAPNHITTVLGTLLELSESLTTEELEYRMSVPPGHRDTYRKDLKGMLKQLLDHQKRKHGQQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA34</accession>
    <name>A0AAD2GA34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS22160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF67">
        <property type="entry name" value="2FE-2S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042022954" description="2Fe-2S ferredoxin-type domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1966575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="324" mass="35297" checksum="2E3E4BA3F1C95EAE" modified="2024-05-29" version="1">MISQLVTVSLLLTKGTLGNALSTPFGKTTRNIATQTLQGAGPATVDLNQYNLPVETIEEEWCAVVVQKTAENEEGIYLGCKSNSEVFVDTFLTTFPRKEGMGIELLELAGGRDDDLGITVVSGLVPGGSAEGSEIMTGDSIAEVSLVRSKTKIGDNRPISEQNQEWTVKTECFSYDATVKAIQSLPPIIEGYEDYFTVKVRRLRSRPKVRVKLQYPPEQNEPDAIIEMNAGENLRQGMLVRGIKLNDPLAKRFDTKSGGNCGAGGLCRTCQVTVMSGGELLNDQRVAEKQMLADNSRARLACKAIVGFGMQEGDMTIRVNPNQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA86</accession>
    <name>A0AAD2GA86_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA86"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1261" mass="133875" checksum="304528EA7420E2F8" modified="2024-05-29" version="1">MSTRNQQSEPGDQRKRQDEGATMHGLPSNSAATDDDPPSNLNIRELQSPDNRRGRSSKSPRTPRGSNFKKSSPSRSSSHHNRRRKSNEKRAESRSNSHGRSDDSKELSPTRRRRKLSADRDSNYATSDDSKEMSLSPRPRKSSGDRGSRHSSRHRSGSRHSSRPRRADVELNLTPRRKSSTGRVKSSPRNRSYSADGISSSDRRKSADKLSKSDRHSMSRSDHGGRSSRDRRNSGDGKRHSGDGRRYSNGGSDKKSSSRSPRRGGKRTVPRPLDFRSKPSKGDTSTEIVSSAAPLAGAIDSDGESDADSENAIQPDVEADRMKADEEVERMKDASARNRSSSRNRSSKPAKRTSTDTLGSMAVLTESDDDSDDNSDHAILPDEEAERMIDTSNRSRSSSRHRTSKPAKRTSTDTLGSMAVLTESDGEADDNSERAINPETQPASLLSPSNTSKRTKASRKKSKSSRGSLESMFSPSSATVATSMTSATTSTLYGNADEDVKAKAKASKGSFPPATVPGVQFTPSYSAVSKKAKVPKESLEHFMLSPSGGATVATNMSAATTSTLYGNGDEDAKAKAKASRGSSQYASNPGVESVSMAASVGGESTSSSAVGTLYGSDADAKAKARAGRGGSTYAANPGVERVALTAAMGPVAENVDEEKGGEEPVARPVSIGGTDSESDSHPIGQSQIHNDDQRKKEEKKEGKKKRRRGVVFCLLCCFLLLGAGIAVWFFVFRNDGSDQDSQINTSGIQDPSTAPSSQATTIFAPGPSGSVPGSPTGAPVLEELLFEPPSQSNCDAIAKNETIAGRDELDNADFGLGLEVVLSENTTMTRSLVDDLLIAIQEKILPSIAGCNIRADEFVEAWRFVIFDAFVSGNAKPDETCKNEELVAQNCHRVNVQLDVFLKGVVRFLDIIRLISDEEVNIANNLELSDPFSIIQLVEIDSLTPTNAPTTMPSDAPSSSPSKGPTSMPTSLPTRSPSKSPTQMPTVPGQTRVPSVEPSLAPSASPTATTVPTALLVVPTAFPTEGPSSRPSMAPIVDPTPPPTKSPTKSPTKNPTESPSTLPSMAPVVGPTPPPTKNPTKFPTVSPSARPSNAPVVGPTPPPTKNPSKSPTVFPSAMPSPRPTPFPTVRPSATPSKSPTKTPSAAPTKPPTKRPTEAPTKRPSTSPSSKPSSSPSTSPIVQTVSFVVLAEGSRCPQGGRDTFFSVRAISSLEECFDLCVNAAGCSKFSYSESNSGVNCGGCNDNAPLTTSTDFIVYQLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBF6</accession>
    <name>A0AAD2GBF6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002407">
        <property type="protein sequence ID" value="CAJ1968806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBF6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="43" mass="4884" checksum="5048C9D87FED2300" modified="2024-05-29" version="1" fragment="single">TSNSLCQIQSSLFKRNELQLSCSSFANFFHNLFAKSQSIEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBV7</accession>
    <name>A0AAD2GBV7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1968018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBV7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="442" mass="49459" checksum="2F99FC5445B6E550" modified="2024-05-29" version="1">MKPKGQSKGVSEWFVRLMILTLGWVLGVLTCFRNSSMNNSAGAIAGGPRTTTSTACSSTALCQPSSTMVTAVPIVGSEAASRPSSRISTEDTATRDAATTTTTTATTTTTTTTTTTIQPLEHSSPHFKANYRRKTTTVSILTDTANPFHRYLSVLGSMDTSKHSEIPLWNSWIHYLEPYHNHMARFRNRQGVVFMEIGVQSGGKIPLLRKYFGPGFQYVGIDINPSTLQFRTQPEDDFSASIEIGDSANATFLEYIKEKYPHVDIFLDDGGHTMEQQITAIQHFLPHVQPEGVYMCEDLGTSWQKIYGGIPNGKTNSPNRKFINETMVGFVHQTMDWFTASTMRGRHSYYAQDIDTISNCKFDCKDSADNPWWKTIPKQVKHIHYYNQLVVFEKGVTQRPTPLQTVGTEIPVGYSGEYDPINWKRILTKIDEAFEAANVEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBV8</accession>
    <name>A0AAD2GBV8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF33">
        <property type="entry name" value="PEPTIDASE S54 RHOMBOID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="361" mass="40892" checksum="CD3B669C971F91DB" modified="2024-05-29" version="1">MQASIPLLTSYARPALIVICGMLLFNLPTLIYKSQMFLRGVAYILLCNDKSWKKPDDPSLVVGPLLEDSSKIERKTVYFVRHGESTWNDTFNKGSHRSWFTFILGWYPGLIKAVLYELYLFLAGKLDSWFYDAPLSNLGIRQAEDLSKFLNEQQPPKEQSSFGDREKFHLSVLTAQPGSPPSKLVCSNLRRAISTVAAAFQDRLSRRPQEKILIIPVLQEISRNPDALSLTPAHAQIHASWMEKTSTVCDFQNIFTNQVDMSLHSGNKPIGTNGLKRMNLFCDFLFSPSVTEDYVIVGGHSLWFRSFFQTFLPYTTIHASQKKKIVNGGVVAFEFVKANTKYGPRYMIDPKSIDVVYGGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBX1</accession>
    <name>A0AAD2GBX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS23059</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1968044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="462"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="1039"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1481"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1418"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1546"/>
            <end position="1556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1968044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1556" mass="177969" checksum="1A58259B5B088B54" modified="2024-05-29" version="1">MHGFIFEILEAWVIEQYGLDTWHTIKEVADCNVKDHSFISRGQYQYSTLLDLLVGTSELVQIRLELLLKLFGQFIVGYLFDSEYGSLLRCQGSTLLEWLSHLNAMHDQFQKSYNSEKFCPPVFWCEESEEDERCIVLHYFSHRGNSLVPMVHGIVDELAKSHFQVDIHMDLVGKQDEHDSRYTSWKISAIDESLAYKLKPPKEAVHKGIPETLKNVKIPMRCPVSGNHAQVHRLNRSQSSRLVTESQQRRSLSPKPDSATEGISMDLMRNVFPFHVIVDEEFRILQVGRNLPKALQTTEEDLRGNHIQEFFTITKPVFAFAWDWQSMNRLSHQNFFLAQTESSIKNKENKAIINFKAAMLALSNDKVLFSLSPHVNSLRQLTEIGLSLSDLSLITSQRDAVSLGEYVSKESRKTNSLDKLSKKLKAEQKLSNSLLYNMLPKQVADGLRMGQTVEPRYYHNVTLFFSDIVGFTSLCQQVQPWEVIDLMNQLYSVMDALTDRFDLYKVETVGDSYMCASGVPDADDSHGEKVANFALAVLECTKHVKSPVTGEPIEMRIGIHTGSCTAGVVGNLTPHYALFGDMVNVASRHESTGMPGRIQCSHELFELLQSGKANAHYEFQERGFVDMKGKGESLTYWLECGTAANKLANPSALERLSREMKDVLVSEQWKMQEYFDKDESTRPDFGDFLSPVAVPRKKLTAVSETNTAPSAPIEMSDWDTLLLDSSISREEIQDKIFDVLFSTLRRCAGKGGDSLTEARKDLLHFVDLICGLYSHENVFLNVANVLMRAEFLLKLRKRSGGYDSWDDFVLLFSAFIRDVDLDADEDSRLASRTGAASLGEGMSMEAAIEFLEDDYEDLCEVIFRGCPRFRKLMRKLAVASAELESEANFRAMLMEFDRTMADTSTEKKALRRKSEVQLGMILILATCGHYCQSYEVFLHWNQLQFKAELQAHKDGISDDPRQEWQEWQAAVFKASVYHLLDRTDRFLTDGMGLRKRANLNETQWRLEGKEWVGAILVPYARLEASLDEKFSYEQHINANIAILEHYLRRVIASHKRNDDVDASESSEYMEATTPYEELQLVIEMAPVANSRRIAEFELPRVVRQELRAFVMSIAGGYNENEFHSFRHASHVVLLSNLLMESIDVAAQGKEGVTSDPLVCFAIVLSALVHDVGHTGVPNGQVAEENPELADRYNNQSIAEQNSIDVAWQCLMSKSLKHLQMCLFGSSESEKARLRQLLVNNVMATDIFDKDLRALRQKRWERAATCDHAKKTLAMEHIMQTSDVAHTMQEWDIYREWNESLFLEMYEAFSEGRSEYDPIDGWYNGELWFFDNWVIPLAQNLKSCGVLSIVSDELVARARSNKRRWALEGEKICRSLWQKARERQMPHMMMQRAHSKSSILSRRSSMHSEESTAVETMLAATVVEEIESLSKVLKRYEEKIETACTNLIGLTYKNENHPPAKQLKHQPWQEVRKHFRKQHWYRNLHDGTHREEDDDNDNDAKVHIAPPTQHALLQEEENREDAIHESDDEDDDMSCLTENSRDAIMKHSQSTIVGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCR5</accession>
    <name>A0AAD2GCR5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002415">
        <property type="protein sequence ID" value="CAJ1968971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="16986" checksum="F2DB849E945EE6E5" modified="2024-05-29" version="1">MACPLFQGRIPCDMDKKWSLFELTKWLLGDSQGDLEAGKKVAGALNRLEGKELQAQLKDFVSSATHGKKYNLFRDLIQEMKEREAKFDRTVSFVGYEVAAVWDPDGKDCKFCILGKLTYHWMFMGNIPHKFLEGVVKHCSTKEYTGALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDT6</accession>
    <name>A0AAD2GDT6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002524">
        <property type="protein sequence ID" value="CAJ1970501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="772" mass="89426" checksum="795D8AFBBED16DF6" modified="2024-05-29" version="1">MDKGVVSAEIKANDRSGIEDSSEDDDSESSEEQVKKRGPFSPGRCALCFFGLPRSYESVVLPTIEKNILRPNAKYRCDVFVHFFDQATEAAGRYNDGGKIDPSHIYFLDGSVRKVYDEFNQARMNRSSMLPAVVQFVNDTDDTFITARRHQLKKYHNSRNEQGNQIYFPWKSNWKNSSMDNMIKQWHSINASFSLMESYGQSHSVRYERVAMLRNDVLYVTPIDIYLLDNLNKTIDYDNSHFVMPPFCRYPVNDRMIYGPYGAVRIWATQRFDLIEHRVRQAKDEGYEMHSERFLDSTVLPTMEALGYHRHMNPDVCFVRTRTNGIVMVNDCFAAGVTRGLVKENRRDIIIQALGRKCSKEITDRDDNTVFYLDCDNVGESTQLSKSESQDESVASNDASVETWKTQNRQMVDDSTESSQDDDSESSEEQVKKRGPFSPGRCALCFFGLPRSYESVVLPTIEKNILRPNAKYRCDVFVHFFDQATEAAGRYNDGGKIDPSHIYFLDGSVRKVYDEFNQARMNRSSMLPAVVQFVNDTDDTFITARRHQLKKYHNSRNEQGNQIYFPWKSNWKNSSMDNMIKQWHSINASFSLMESYGQSHSVRYERVAMLRNDVLYVTPIDIYLLDNLNKTIDYDNSHFVMPPFCRYPVNDRMIYGPYGAVRIWATQRFDLIEHRVRQAKDEGYEMHSERFLDSTVLPTMEALGYHRHMNPDVCFVRTRTNGIVMVNDCFAAGVTRGLVKENRRDIIIQALGRNCSEEITDKDDNTVFYLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GEC1</accession>
    <name>A0AAD2GEC1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS24283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002491">
        <property type="protein sequence ID" value="CAJ1970263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GEC1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1970263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="160" mass="18559" checksum="3A918F4792B3DE71" modified="2024-05-29" version="1">MFSQRFSTLSRSIIAGKKFVVPSTSTSVSSYLSHNHRCFSSAPNPLDAFRDSVDRQTRASEPVGRPWSVKELRRKSYDDLHKLWYVLYLERNMLLTEQQLSRTRQLIFPQPQRMKKVQKSMAAIKQVLGERKRSKIASFQESRMAEEMAANAEEANEVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI90</accession>
    <name>A0AAD2JI90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="597"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="721" mass="79404" checksum="FB68677C86A4DF7F" modified="2024-05-29" version="1">MANRWGDPQQGSSQSSNDKNNTSLEMAMSGMNIVSAFGTSPVEFSASPDMQSEFSEELSGHQRKHIIDSGDSVHSQRSNNSNASPLPSIPTHRLHGVPPIGRPGHSKSSSISTSQSLTLTPTSSLDGTGTDIHDYNRRSKEEQELPTRITATFGDGFDGIHGARERANTAPGTMAFPSSLDSSFGSASAHRGSRNQLPPSRPPLAGASSYNPDFSVLSTISRPGYLPHSGGDPYLQRSTSDSGRESLLSSSYPGQMEQQSSKLSSFPSLPQQSGLNPNQPSFQPVSRHQRSFSGPVPVPVPDYMNQFQHHSEPPMGHTSQVSDFGVLPIDQGLRLAQMRYRNHSFGSAEEVSRAELHRRSSLQTLPSAGGFYGQQNQFDRRESLDYVPGHDMFMNDFDRARHVSPGHSPVHQHYGHHHHAEALSAQPMAMGGGGSMRMYGGNKRNSYGNQPPRHHRVPSLDDDSSHPLAGESIEVPSDDRGYMLDSSSHSVHSLRSGSESSHYMPEAVQHLPTAGASLPLAKVVYSVKFKRTQRSFVIGPRLNRDLKIGTYVKVEADRGEDLGIVVGKVSPEKRNYRGDMSIMPPATGTAGNTSDLKRIIRLATHDEVSLLSLKREEEDELLKICRTKVRQRGLPMNVVDAEYQFDRHKLTFFFEAEGRVDFRELVRDLFSMYKTRIWMQQLDKNTSAACRAASNPPVPVAMDFGTPIIAPMSEFREFMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJQ3</accession>
    <name>A0AAD2JJQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="93" mass="10278" checksum="60501C2CF9EB0A93" modified="2024-05-29" version="1">MRFHQKALITIGQYLKSSVNEGLILQPTDSFDIECHVDADFAGLYSVEDVMDPTCVKSRTGYVISVCGCPVVWVSRLQTDIATATMEAEYNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKP0</accession>
    <name>A0AAD2JKP0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="14267" checksum="3E1942BF5AB901ED" modified="2024-05-29" version="1">MDDCETLRQKKEKCFAKNGEKAEKCRVFKLKEKRCLAFRHCPVEAIPYYGTLDAEKAMCGAFEEAFCFGNPRIMGIDSAKEKENNVKIYKYHQRALGKIGGNRQKFRQCKSISSALSKCLRQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL56</accession>
    <name>A0AAD2JL56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL56"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041946877" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14276" checksum="4354912FECD23094" modified="2024-05-29" version="1">MKKQLLFTSLSMAVSLVTVESFLVPLGTQSSSSRLLSSSLSSDGFGLRKMSKELMQQKKEDQQATNDPAANDVASRFMSFATSSPNKPLTTSISQVQSPSSAKRNSQTKDQTQQHGTLNSRIPSVFTTNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL80</accession>
    <name>A0AAD2JL80_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL80"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="444" mass="50554" checksum="F891BD83ACCBE200" modified="2024-05-29" version="1">MHTNTLHKQQQQQQQQQQQQQQQQQQQQQQQQTCTQNSLEYWRWPRVMGTYGTHGTKVFGRLVTEPNNDILHRSIMDTIAQSMNEAPNGVIVGTEEFDQVGPDALNNAIPAIKKLIRHLNLNNEDVTFVLNYRSPRLDQWVSIWKHEEGDFMDSTYEDFLCMSHNDPAERRRRFDMLGAQMNPLGAAQIFLEEGWKVKLIDMGGVENDDKDISHVIGCRVLLAGCIDGFLGSLGDELPRENAVEKPFDELNDEESGKMEQLFQNRDCGYQHSLKKWIDNGQMEIEYQDTLWKSCESGRQSYYTSLVGATEVLFNAFLSQLECKDNPHDLRDGITMDQALGNNNTIGHMVNGFVEAVLIPLVFLGGVGYVMMMMLKGKQQRRLDERGIAVVQAEMTPYPSSAFQDDHENEGGGDDDGDDDENDSDDDVEEVYKDPAKSEDDKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM26</accession>
    <name>A0AAD2JM26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002110">
        <property type="protein sequence ID" value="CAJ1962530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="222" mass="25215" checksum="C14DA6D03CA892B2" modified="2024-05-29" version="1">MIGSSIITKPIRHVRCHSLLASAWNSGHRQLEPERICRQNNNSQTNPIARNHSSNGNSSSIDHDSNDFQIPKPTWSIRDLDLTAKRPPLPEEELDRLSKLALIDFKAMGPKDQESLGQDLANMLHMIDQVTQYDDDEDNDNDNSDSGNDDENIQAAAQIYDLVRGGLTKAPLRKSLEQDHLQDKDEEIAKDVWEKMLQPKTKRMGGRHEYFAIQTKTEETSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP91</accession>
    <name>A0AAD2JP91_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002395">
        <property type="protein sequence ID" value="CAJ1968641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10503" checksum="F2CD981B48E29024" modified="2024-05-29" version="1">MSRGDQRDRDRQKRQAREASKNNVTQREGTPQQRNADDKAALLAKLEAKKAKQLAEPLDQNANIPVPRKKGKKQSETLDDLLSAGLAVGKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPF3</accession>
    <name>A0AAD2JPF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002425">
        <property type="protein sequence ID" value="CAJ1969762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="628" mass="69289" checksum="0F294939A351A477" modified="2024-05-29" version="1">MAGPQEESIAAESPQSQLPQQQEQESLSTPNTDTIVKEELNQLNDDLLQTPQELNDSASDVTSSVSSTASSSDAILTPQAMRRPSNFEMDQFNIIFHKTLKEVEKIARLRVGDTVITPFGEGKLLELGESNKIALPWGILCTRLQNIHRKLPELEFQEAMDHLNEVRKLHFAVECQKLNIPLQIDGCTACLLERPEYKVKRNQNQSRWNRFKQRVDESRKNKKQHLWVCDVCGNPVCKFHDRQQQKGGGDHFHMCVDCSYDLNQVEHQLNPYHPNVLQSLERLLLLYTRMCLQLSFWMPYVPELCSQIFQKQRKNAKISLANTSLGFVGAALGVASAATMLTPAGPAILIAAMATSATSGTLQATHQGYDKYFSSKVTHEISDRLIAWQGLCCGILQSLEQLRRDLLAERQHFSASATFGHFSIKNNKKEADVWSTLAVGSMGVTRSAFTGVGVTASMGAGYAQVINSGLQTIPLVGAAFSVTYMAMDAGNIYSHLQQLSTPNSYIIRLKQLQNAQTNGGLPHVSTVETEVDMLDKAIRDINSKIKLLREEQDSTPSQVEEESDKVKPAQDDSEAAATVVEAGPIPTLLTVQEGALEGTATAPMEDAGEEAASLDGEMTSDDEPNNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPM8</accession>
    <name>A0AAD2JPM8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS24114</name>
        <name evidence="14" type="ORF">CYCCA115_LOCUS3111</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000230">
        <property type="protein sequence ID" value="CAJ1932989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002458">
        <property type="protein sequence ID" value="CAJ1970091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPM8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01060">
        <property type="entry name" value="Membrane-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="13">
        <location>
            <begin position="85"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1932989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1970091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="436" mass="50994" checksum="FA08E6EBF57EFA5F" modified="2024-05-29" version="1">MCRQEVAREPKKAVADPAELQKGDEWLKDFDFEGFATEIKELGKKLDAEQGEADVAHLNKMIMWSNSCAAIGLLTMGFLVNPITIVCLSLYTCTRWTMIAHHTCHGGYEKVHPNKDRWSRFKFGLGTFWRRFNDWFDWMMPEAWNVEHNNRHHYNLSEIHDPDLVEQNMEEVRDLDAPVIFKYMMVGFTMLTWKWYYYAPNTYKELKLARLRRQGKAIPEGVQPELAVTVKSALMGQSHFYSFAELMAVVLLPYFILHFFVAPLPYLLLGEHLEGYTGQGMYWTAIKNLFLAELLTNVHSFIIVVTNHAGDDMYRFREPCRPFSGSFYLRQVLASVDFSMGSDPIDFWHGWLNYQIEHHMWPNLSMLTYQKSAPQVRAICAKYGVPYVKQNVFWRLKKTVDIMVGNASMKWFPESYEQEYLQKDSKIEAANYKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU14</accession>
    <name>A0AAD2PU14_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001729">
        <property type="protein sequence ID" value="CAJ1947497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="120" mass="13728" checksum="4AA8BD21A06220AF" modified="2024-05-29" version="1">MMLFQHHNTGIHLDSGSTFHLRTNEDDFKEGSLQGIHGGFHYASNVKGRELYQEGIDKVFDSVCKLDTRASDNVNSLSNMVQDGFDVFMDTNRENSFFVTRNGTTWRFGHHCRVPQKAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUQ3</accession>
    <name>A0AAD2PUQ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001777">
        <property type="protein sequence ID" value="CAJ1951032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="517" mass="58296" checksum="F4EA0291601D3BCC" modified="2024-05-29" version="1">MTVLDVKMDLTRKARICARGDQTDPPMSATYASVVTRESIRLAFVIAALNGLNVLSADVSGAYLNAKCAEKVYCILGKEFGEYAGKKAILVKAVYGLKSSGFAWRSLCADVLKEQLEFQPCRGDMDVWRRPCQHKDGSKYYEYILVYTDDVIAISENPKAIMEKLNNFFVLKPDSIKEPTTYLGATISKHKLDGDDYFTWAIGSEAYLQELLRVVKKPIVPMQRTLKKNVYSTSPTGYKPELDSTPFVDDDTAIFYMQLIGILRWLVELGCIDVAAEVSMLLSYNAMPREDHFHAALHTFAYLQKHPDRVLVMDCGYADHLRPLKKADYSQFYEFTKDELPSDMPTPLCKAVEFTMFVDASHAANVVTRQSRTGVLIFVNKAPMIWYSKKQNSVETSSFGSEFAALKTGVKLFEGLQFKLRMMGVPIQGYCHTCVENMSIVNNSSVPESQLKKKSNAVAYHYVRSKCAIDILRIEWIISAENLADVLTKIQPGTVRDRLLEQIMWKAKQNGKLALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV15</accession>
    <name>A0AAD2PV15_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV15"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="102" mass="11019" checksum="ED8AD2D9F1B8F66F" modified="2024-05-29" version="1">MATVRSWPFLALGASHFCKFNGKKKDTVGAVEIQQSANMEAASATKDHFLTGGDELWHGAPEFPRETSSRDATCPGPSALEKQELAAILMFVAQQKHNNTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW40</accession>
    <name>A0AAD2PW40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="44"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="259" mass="29125" checksum="62772F517B1686BF" modified="2024-05-29" version="1">MNRSSSTNSTIQAVDLNFDSAVSKFAPKSKQCLPESFQPLADSVIIGKGKMPAQASGNRRLRELVDVHLQNYANAKYKRDKTFIVTNILQSIQDLCPVGAFVKFDGERWWEVSDRISREKIACMFRDSLSGQYKSSNKNKVAKRRAQRAKKRHAAISMQKVETQQPPCYQESLPKTPAAQSLEPQAFANNLAEPPKMTVAPFKRVSKERDSILVLEGLDFNGLLDVDRNVFDCADFFSEDAAKVSSDEESFFDEQVFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXK2</accession>
    <name>A0AAD2PXK2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXK2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="104" mass="12090" checksum="FD5D3AD23C7F95FB" modified="2024-05-29" version="1">MKYKDEVLGKRIEVEFKVGTVTQFFPGTIQKLKMELSDGIISCHHFIAFDDEDEYWFDLEKKETANQLRWPEKENIPQPDAKKLKTDDASSSIPQFPIIVLQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY28</accession>
    <name>A0AAD2PY28_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002429">
        <property type="protein sequence ID" value="CAJ1969823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY28"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="351" mass="40348" checksum="A5E53B03EE139F44" modified="2024-05-29" version="1" fragment="single">MHLQLIYVNLRTGRDPSVNNDLEIQELIASLPPLIDFGLSTHKLIAIGYDYNSTKISFGNSTFNQWMEDHNDRWTQALPRFDSPFKDLYANYSVGVRVNMLFAQYANDWRRVLKFLISLFDNDALGNVEKTTEYTWGVRAIALQVAQQIPFSFFDVGLVNDSKVPQEDLYFLRDDRMNPALRNETPLVQFWLMCASIFDHPWTMLFDEFLEESPISCIQEIKLKVIEGIPNDETNKVDIHKGVKKIFDPDYEDSEEEDDPMGDEDTGLVNKFGQPDGWDSDKTVDDSNDRRNDMEIDGELASGDDRTHDDDDDDKGEVEEDDEDTDESTKDSVILVESTYDLTDTANDEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY77</accession>
    <name>A0AAD2PY77_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS24350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002499">
        <property type="protein sequence ID" value="CAJ1970331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1970331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39402" checksum="1D666103FCE88D2A" modified="2024-05-29" version="1">MDGMEENIFEHNSTLVESESNTTTITTTVSSSSLSPAQESVIALLPILPSLLSIAGSLCIIRLVHRKKYRAPYRRLLFGMSVYDVFSSLFVPLQSFLVDKETSRRRFAVGNEATCNFLGWGFQATCGCFLYFGALSTYYLMVVRFGVKDEYFARRIEPFIHGFIILFSIITAFVALGKNLYGEQEIGAGCYLTPNESCDAACIANLALILTGIPYVFTLFLVLGNNLTIYCHVRRTVRQYVKNSQDRAEKNLSSVLVSDRIVASNRDGSVDLDKSIEETAAVSFKVTKRIAQVDNQQKRVQLLHRRRAWTKNGSGFVSVHGATSHLCSCHGIFKFSHLYQTSVFATARTNGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAD0</accession>
    <name>A0AAD2CAD0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1901814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1901814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="372" mass="40797" checksum="0755457682E42E97" modified="2024-05-29" version="1">MATEDVETIEFQTSVIIPEIVTAGESAQGELSPKGLAEQLEEAKLDAKKSAEALDDLISGVRAVKRILDKHAGDEKASMKESTTRDAELIAHLSNQLPGILGSDLMALVNAANMARGHAKLASDEAEAAVSEMQEARKEAEESNTKARTAAKISKKLYEDNLALQQQVGHLKKERRTLVKAVRDLQQEQEQTNKFDTWRLLEEHVQNSLTMHEMILKTPTRGARQNSFFDPAHESTRSMSDEDGSNYISASSVEKPEKPKKFGRISPTPTASCSEDSMSYHKHEGHSTPSRSFEDQENVGMPTDVSLIKRRPTSPLGTPIISREGNGAESQELKPICDPQILRTLAIPGDDRVGGPDLPSPRVRVAPGLYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCN3</accession>
    <name>A0AAD2CCN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000057">
        <property type="protein sequence ID" value="CAJ1928633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCN3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041940885" evidence="2">
        <location>
            <begin position="23"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1928633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="424" mass="47588" checksum="98A1B177A781EB70" modified="2024-05-29" version="1" fragment="single">MLSLRSIIMIFLLLAMQPMAMPSLMSANYTRPSTQVSSLANENIVSTVDFVGTAVEMESTGIPSFSLAEFIMSIDYELVKAFAQDFSKKYEAFAEAFTDAMSAIFEFFSMEYNAYKQSINYESINAFAQLLNEKYEAFAEAFTDAMSAIFEFFSMEYNAYKQSINYESTNAFAQVLNEKYEGFAQAFTDAMSAIFEFFSMEYNAYKQSINYESTNAFAQDFNKKYEGFAQAFTDAMSAISAIFECEAFHHSIDDESVMSLAELLNEQYEAYAQAAFTAMYSKLELFIQKLEAYNQESHVEYQRVYKKLEDVASDLLAAAPAWPSLLDPEFIVRDVFDGMQSYTTKDPFVPAPLPPLPSLEDAQSIAAMEVVLDSSITFGAIVIALLLVATVTTIIYASSVIDRELISMEDLSIVLETPCLSMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD82</accession>
    <name>A0AAD2CD82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF8">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042252858" description="NADP-dependent oxidoreductase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="462" mass="52230" checksum="189387513CE8E82C" modified="2024-05-29" version="1">MKASISLLPLLLALLPLEGSGQGLFSRMAKFAKTQFVGSLLKGIPTRTLSNGVEFPLIGLGVGNMLMDLIPSMISRSLQPDKKVYLFDTSNISHNELYVAKGIIEGAEILERESGVDKIEVHVITKVWYTHLGYDRTLHAVQNSINAFQEAIDHKNVDLKLHVMIHWPRCYDNVPWMNCELEENELPQDVKDAGPPPHLDKANAWKNSWKALESLVMNEENVVSSIGVSNFHLKELKMLDEMATVKPQIIQTDAWSLLYDPMMIDFCHKHDIHVIAHNLMDGVFLKADKAPFAFNHLALVANELTKDMKNKGLLPSDKEEVTPAQVILAWLVQHSISVIPRTVNLRHLHENSAVQLGSIPAMNEQQVQTVALSVEAMISEEDMPDDAYVKITFHAKTKDIYLWWYDQEYGGEIQVAKIDQGSTWEESSHPGHIFRVYDGPEKNSYELFSVQGRYGDHRHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF74</accession>
    <name>A0AAD2CF74_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS897</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1920679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF74"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01200">
        <property type="entry name" value="WHEPGMRS_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="15">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="242"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1920679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="706" mass="78467" checksum="22AEC1556B009D8C" modified="2024-05-29" version="1">MEDMSKLQDELDALNAKITKQGAEVRQMKKDGAAAEKIGEAVNALQALKLEAGTLTEKLKGDEPDFNRKAFDDLIIRKMFVVPSFEIHGGVKGLFDLGPPACGLKAAMIDLWRKHFVLTENMLEMECTCLTPEVVLKTSGHVDRFTDLMVKDPATGECFRADKLLEDAIDDLIEKNPTMPTEEKEDHLRTQRQADAFSPGELDTLLTKYGCKGPSGEAYSPSFPFNLMFKTSIGPEGTSVGFLRPETAQGLFVNFRRLLDANAGKMPFAAAQIGNGFRNEIAPRSGLLRVREFCMGEIEHFVDPNDKSHANFPTVADKVLVLFGRDDQLGSGKTKKISIGEAVKSGLVNNETLGYFMARTQLYMEKIGMNPECLRFRQHLATEMAHYAADCWDLEIKSSYGWVECVGHADRACYDLEVHSKATNTPMVATVKFDKPQEMEVAKLKFDRKALGMVFKKDARTVSAALEALAESWKDFEPIATALEASGKTTVDGFEITKEMVSWEKTMKKVHEAKFTPSVVEPSFGMGRILYSLLEHSFYQRDMDEQRNVMKFNPQVAPQKCAVLPISSNPECNAAVDEIAAELMQSDLATRVDKSTAALGRRYARSDEVGVPFAVTVDFETLTDGTVTIRERDSMVQVRVPKKEVCNVVFDIVHQRTTWEQVTKNYPVVQVDEGDGTPAEKGADARAKTVVEANSRGRFSRPAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFU4</accession>
    <name>A0AAD2CFU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000125">
        <property type="protein sequence ID" value="CAJ1931111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="73"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1931111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="538" mass="58636" checksum="1CFBE574B3A96A3F" modified="2024-05-29" version="1">MRSQENTEDWTVNDDKESFANIPASPVDVLKLSFAPKHESIGVKSSTTYTSACVSIEACDMPEDEAERTCSVDICVALDVSGSMSGSKLKDCKSTLEAMLRPLSTKDRFGLITFGSRCDVVFPALLMTKENKAAALKKIKALSTNGCTNLSGGLSLAWQELLLVDNPNAVRSLFLLTDGHANEGITTTPELVEMVKSFNADSASDISAALNESQAARRVASLRPNKPSTRRRRQMQKVKKPPSSSSASTVPQTINLTSKGAPVSLFCFGYGSDHNSEMLEALSEATPGGGYYFVENDSDVFTAFGDAMGGIMSVMAQSAVLKISVPSAASECGVKIREVHHDKKVDRGDGSFTVNMGDFYAEERRDVIVDFDLANVTSNEPVLHLVATVSYMNVLTKKNTQGGPRDCSISRPDSADLSAVNQDVEAQWLRVCVVREMEEADKEARSNNREQAQARMRRVAATIQASPAYNLEDSFYCSLQQNVDESMVDYEASSYKGHRSKNIAQTLKKQRACSSKSSSNGYYQTKSKKKMSKAFEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH44</accession>
    <name>A0AAD2CH44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1918675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000113">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="704"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1202"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1071"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1233"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="786"/>
            <end position="793"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1918675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1329" mass="148134" checksum="EDF6560163720ACE" modified="2024-05-29" version="1">MPAHMPPTMAEREAELAALQSAFDEYIASSRELEEELDAELAKMQEKLADSSAANAALSAQLENIAPQLAALEKALSESRNKLKEEQKLRRQAEQAQDELEAKFREAEGSLLAVREECDAVHEELAFKESELEETRLELEIEKEKHRVEMEDAMENAGSGGGGGDEGDKDEAKEEPDEDGDLFPTVDDAYVKKLEDELELVTEQLIETEARLSQTEEKLSEAEEKTKAAEETGPSETSEEDKNTMKSLQEELDAKSESETKLREELELTKEELSLTQEELKAVEFDATEVSGKLDTMRAEHREEVNKLKNLLNDQEIEAKVQQSGGDTETFEKALAAATKETVTYKDEVDNLNTALANAKADHAAVVNELEEVQQRFDEVRTEAEKRGKEAAGAEIRAELKAEREAEEAKFKEQLKKIQEENAALQQKVNDAEIALATAKDGQSKGEAGAEESSELVKQLQAQLAAAKENLAKKETEMSASVTEMEGKVGSAEEKVGKLESELSETKGKLAEAEANLIVIRREKEIAEAKDVQKANLRKKNEGDGTAKYRSELIDMDEVQKITRKRRYRSNSPNNIKRLEIKVEDEQKKYKELEVEHDKLKEQKRIGDAHINRLEGDIKVLQKQLYQSGDMGTKTDMSRLSSLASGSAGGGDILSEDKSKVQEVIESGDVEGMKKELLYLDKKCASQRDYNNQLLSKMLALQGNIQVFCRIRPMSIREIQAGYKTVVESLSESELGCFDSRTQAWKSFAFDRVWGPDQSQQNIFQDVEPIALSVVDGFNACIFAYGQTGSGKTFTMEGAEENNQRGISYRTIQKVFHLLSLKKQQEAAAAILMKTTEERTEEPDEFVFEINVGMLEIYNDECYDLLGAGGSTLAEKKAEAQKAGGKASLDIRRNQDGRIEVPNLTKETVHTIQDVIDLLKRGNKHRAVAATSLNSQSSRSHMVLWVDVKAGMKSEPGNNGTLFLVDLAGSERVKKSEVGGDNLKEASHINKSLSALGNVMEALDRKAAHVPYRDSKLTFLLQDSLGGNSRTMMVVAVTPVDYAYDESIHALQFATRVRRINIGAAQRNVTSKNLEETVKALTAEMKTLTRQKQKTDSQLNNLKKDNDRIQGKLGKIDAARKASKSDNKTLEVLRKNNDDMAKRWQKEKSAREAALEEAEKATKQLAKLQKSVSALTREQESLKNKLDEKDKLLEKKATELRTAKEAASASNIRARKAQVLGSRAEPKARTKRASATAAAPEETSATPPEEVKEIREKVLALLKEHDQGKVNRIDIIMEKFKGKENLLLEKMTQRYESGTAANDAKTRSEAAAQRHMLRMKKLREKKGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH94</accession>
    <name>A0AAD2CH94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4 8">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4 8"/>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1921070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="673"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="710"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1921070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="768" mass="84269" checksum="B6EB8C3E60B21175" modified="2024-05-29" version="1">MNRGSNLSKAILAHRRKLLLATGTTAVTGASFFSEENSSLPTLDKHGKRLDRTFAFPSALGLATMSTTECKEAKVKDLGPTTIPIPTRDEQLSKLKKGETFDILVVGGGATGAGAALDAATRGLSVAMIERGDFGNETSARSTKLIWAGIRYIATGFSALLRFHNITRPLDAISDFMGEFNMVMGAHKERRILLENNPHLTNWVPIAIPFTSWVSWPAPFGHPIFATAPVVMPLVMKFYDGMSGFTCPPSHIMGKKRAARKFPQLDQDAKYFSVFYEGQHNDSRTNTCIALTAAEEGATVANYVEMIDILKDKSGKATGIKCRDNLSGKTFQVHAKAIVFAGGPFTDSLRKMEDKNSEPAVNAAAGTHIVLPNYFCPAGIGMLDINTSDGRFLFFLPWEGHTLIGTTDRKGPAESSYGPPEQEIRYLLDEVQKYLAGDIKVRRSDVLSAWQGYRPLASDPNAPPGAPVSRDHIISVNPDTGVTFITGGKWTTYREMAEDVIDRVISLHKLNPPKESSTATRPLRGGVGYRRNLPITLVQDFGVSEESAKHLARTYGMNALDVCRMATPTSKRWPRFGNVLIEGFPYLEDEIPYICKHEMVCTLTDMLTLRTRVAYLNKDAAIAAAPKIADLMAKELGWSWREKKRQLNDALEVLSTFGGPIPDKAAAALELSTELKTVREVFEKMDLGSTGYIDLTEFMDCCTMLGMPFKDRQKAKKAFETIDSKGDGKIDMGEFVAWWEKGGGLQAQIANKLKFKATKETSVGAAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHS6</accession>
    <name>A0AAD2CHS6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHS6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1926420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="510" mass="57069" checksum="ED460D6025774363" modified="2024-05-29" version="1">MRRNGYESGDADTYSLSSAGSLDLHDPSDLDPMVNRKKRKDKKLKRQQKALTSLQLPQLNYKDTPTIRILVVADVDLHCASALAEAALVSTADNPLRKVDLCIACGPFCKEDELNIYYHGRQRTLRVRPTPSSHYNNETLSSSSSSLQYRYHHNHHQQQVRPQLPLITSPYKQQNFHDKPIKRSLEENAALEGLMTAALSQLESIVCRVLYIPGETDPIFHKMKRRLTPNSRNIHQQWMPLCPGLGCAGLLHLDWGKYEAMYGGDGIDEEDEDNDDDEEEDEDDNIDDSQADYGSDSELMDSYRHDDNINQSLPPLEDNIYSDSEGEASSIGSESDMPPLTDAVPSDSRTTGRQYSLDHCNSLEKLVNSAPNMNAVTDTPLANQTHPTIVGFHKTELFQTILVTHYEHLAHNNGDSHHADEELPCLPAQHDDFCDLPEVQEHVCLEIASGRNVHGEAIAPKCVSKGPNLTVLLPGSLKERGDYCLLDLAYVVDGNNGCKWSVTKSEFLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHT0</accession>
    <name>A0AAD2CHT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000386">
        <property type="protein sequence ID" value="CAJ1934795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30734" checksum="467F08F991FCC042" modified="2024-05-29" version="1">MKRLRVSLYQAIKKQIDTRRNGAQLQRNHKYARFIQECMHNLAFQQVRNTNKGKYDADEALVVARFIQQIREGVNGGIDGQDGVSFIQQYYLNKGLKIFKERGKDAAMKELDQLIKRSCWTPISIEKLKPTERKKAVDAMMLLAEKNDGVTIKGRCVFKGNETRDWLSREDTASPTASHEAIICTGVIDAHEGRNVMSMDIPNAFIQTLMPEQEEGDDRVIMKITGLLVDYMIDLDPTYWDFVVIENGRRVIYVVILRARTRMDNCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIJ8</accession>
    <name>A0AAD2CIJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">O-acyltransferase WSD1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="2">
        <location>
            <begin position="408"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="579" mass="64285" checksum="B135C2F3899A696A" modified="2024-05-29" version="1">MTSLFLSSLRQGAQYAALPSLVSGCLLTAHTATASSHGGNNPAYPTTKCDSAASRSPSLLRRRMTAVGRFSLLSETRSNPSIPVLVLALSGKPLRAQDFSRLYQQREMGEKHYRFRSVTKDATHFSLVPSQDFELPIQESLVYPLIYRRELKAWITDLLLEPLDLSKSLWQVKTATGGNIGQSGAISTTSSSTEDDETTTTSVPLERHNQLLDDNVESLLLFRAHHCMADGVSLGALFVDFMDEREEMEEMLAGKIGDFKKNRKRKSWFQKLLVMIYYWGWGSVKTFGYQLYLYCANLKSTLSRSNPWKKLRRAYEAKSKSEGSSKRTLSWVSVCPVDEVKEVAEHFSTKKQKVTINDIFCSCISAAIAKLIQYHQAQNPELSLRLPYMNLVMPVHMFGGVLLPGHSMGNKIGAMVSRIPGTNTTSCTERLMQVHNTLYARKMTPAAVWSYLTAKAVGTVGFGGGSSGPIDSSAADNTFIPWAFEKSHANASVVVTNVRGPETMVHLDGRRIERFLGFLPLPPGIPVGMVVQSYANNLTLTIMAEPWAVPDAMGDLFLSWVVEEYDALRKQANIQPMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIL4</accession>
    <name>A0AAD2CIL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS4552</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041540">
        <property type="entry name" value="VATC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18716">
        <property type="entry name" value="VATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VLRF1" evidence="15">
        <location>
            <begin position="253"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="610"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1935216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="708" mass="78594" checksum="23225B4EBE3B2277" modified="2024-05-29" version="1">MTIHSTSTDNTDIPIPIPIPIPTSSSTSTSNNGNGNNNKQLQNKKSNKAETLWLYDSKTQALLKQAHEQAVQKQQQEDASANRLYPVVRTYDEDYDQLSLPSEDEDENENEEGDHSSSSSNQSSSSEEEEKEETQDKESTATKGKQTKPQKLPKATKKKEMTPKQTIRLQQEIRQHYSNLIKTAVPIAIQQDDNAAESSPPLANNTDSPSNAFTHNLQLSSALLTKSEQQYGTPVSKAKAFCDLSTQLSSNSDTGYVVVLLLQSGKFAGGVFLNGRCIEHKTMQKYTVRKGQGKAQSAQDGKRKPKSMGSQLRRQGELQLKEDIQTLLWKDWKTFLQKASLLLISCPKTMVSTLLDTPTGPQWSSLHNHKQQPILSRKDGRIRKIPINVGRPTYETVYMVHQVLLQVSLEPITIMDGGGDNGRETAAVVETDTTTADHQKNKDDSSKEPKPNEEEIDETIPLLHLHHLCKAGNHGELADWLQTTNGNDDDSRAARKSINQQAGVDFMTPLHYAAASCVPPPSASPSEKNNDSVDTPSSPEQAALCVYDLLVQGKAVPTILDTRLRPAYFLAGHDKVREAFRKARAALGEDYCDWKAAQVGPPLSEEVVEQKKAKEAEKRRRKKAKAKEKKAMERQAQEEAAKEKAKQEEEERVTGDASGGRACDCCRKAIRGRKNVFKRLEYEYCSTKCVNDHKRELMASAALARFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIM0</accession>
    <name>A0AAD2CIM0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000102">
        <property type="protein sequence ID" value="CAJ1930031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1013" mass="113218" checksum="8438082CB9253FF1" modified="2024-05-29" version="1">MGRSSSGGGMGHVTPQKVTSNSSSTVVKHLFSTKDENDGKARLLYKDADYIQASGMKCSKDMVKSIQDGKSIDFIAIAPRLNAPTQTEAVARETEMAQNKILYSAKLDKNMRRSAYFETNKRTVKSNIMLKFVTKAMDIKLQGEADFTTTLEDPITPLKRIERFMKKSADAEYDFLDFWEANQKFFAMKQGTTENLMHFKEQFLRQAEVLQDLYGIAWFGNFAVKTKAYAAIASTDTAAQDKFKDDIFEAVLATGFLCNCNQRRTAPLMLDLQTNYCREVDYYPKTVSKAQDIMKIHMDVIKNPGVNLYQGKDQPKKDRLLPKTQWKNQDQYVDYGKKLNLNQIGATVPATVPAIVPGASASTSGASIVVGSVNTPLRLAGTTGNQMMQVPLGMQLMQIPTQGGGTVTVPYSMNANGEIAFGGMQLSQQGFGGAQVHQGFNATQARTLQAVKTGYYDTSNVFHNAIKGKDENGNDVYLIPWPAGTTNVKLQANWHYASEDEDVPDLATEADRGLQFIESRRNERDPFGLYDHVIMDSGCTNTTICNGELMHGLRHAEKELDMHTKVGSRVLDEEGFLGRFPPPVYHDEDGIANVLTMREMIAAGYRITMDTDTDNAFIVHCDGNRKMRFVNRKGVYVLVQLGANVKQGAKETSAMYRRQLSNLNNQPHFELSSNKQNGYAGLKMTSKMATVQKNKDGFTPRQVIAAMEARSAMHILNASSRVALARLPYKVPKVITECLGRRAAELLNVFPQKDSISSHFSPQQLIDNVSINYKSDMVAELGQYVHAIGTDSSNLMEPQSIKAIYIEPTKGQRTGHRVLNLNTKKMISQPKVVVLPVTNQVIQRIEAWDTAKGVTSMKFFDKKRDLETFQDGDQVAGVDDTEQGYLEEAFDQDYEPEDEDERDFNLHGQFNDIDDSEREELLADADNNVDDMPELTVRFKGDDDYESDDDLGDEGNEEEKPIVADLDHHQENVERGINDIGSLVTDLEDLQEPPEEEIVFVLGKRMRKLQCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ55</accession>
    <name>A0AAD2CJ55_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000369">
        <property type="protein sequence ID" value="CAJ1934709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ55"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="entry name" value="Phytochelatin synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="294" mass="32835" checksum="F358335935611D97" modified="2024-05-29" version="1">MDESGKPMVLSPMNVNTLASQVSRFFIINVVFSLIVPSYVVSTILRGKIKLSELKLIYKAVGEAHANPINSLPEYQDKELIRQLWKKESARPYIDGDALEYQKREGYCNSATIRCTLKSFPGYPTEKIPPQKSEPADPEKWQGMSAWDTANDNDGDESPSGNGSTAKRSANLEMFPGSCSFPEFLTAIKRGLEDPNCRVVLNYLRPVLFGFAVPWWLPANMCLALVGGHFSPVVGMVETEKYRNDNPLIGVFDVNHKYGGAYLVPAKTLFRSVQLMDVSSQKPRAMILVHDPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL88</accession>
    <name>A0AAD2CL88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Multidrug and toxic compound extrusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS5193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893:SF46">
        <property type="entry name" value="PROTEIN DETOXIFICATION 44, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PROTEIN DETOXIFICATION 44, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042061461" description="Multidrug and toxic compound extrusion protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1936441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="66126" checksum="B2B447E981191859" modified="2024-05-29" version="1">MTNIFVLVCLVLGSSDVALGFGSRVLSTTRPTNLESSPVHRSLQILGTQDRKDHRQCWGQRRNEALSASSSDDEAISNNDNSTSKERTSASDGLGVEGIPDSSMDCCGSEPVDFLVPPVNATNTEFESSSDNTILGSEEEIVSTSSAIGTNDEDSSNTLKVWPCFDQLDKDLIKISLPVIGNFAINPLIGAVDLFWVNRMGNALAVAGQAAANQIFSSAFWFTSFLPSITATLVSKQHAKGDKEGTQDAVCQALFVGFFIAMIGTPLMFFNPDRALSAVLSKGAPALEYARPYLLIRSFAFLPSMFSLVGFSAFRGIMDTQTPVKISAFANIFNAILDPILIFSLAMGVPGAALATLGAEVISAIVYMTLLRKKQLIKWRKLIKLPSWKSLEPLLKGGLALQLRNLSLNLTFLAVTRVTQAIDKTGVAAAAHAMAIQTFQIGGVVLLALSTVAQTVVPNAMVERFDEKSQKKVGGMKYAKAMVNRLMSWGFVLGCVLGGAQLMLLPAIRKASPLQEVRNAAMLPAIIGSVLQVINGLVFIGEGVMIGTGSFLQLSLSTVVATAGCLWGLKVLPPKFGLGGVWLSFVVFNFLRLAGVWLHQARNGPLAKRNIDVKAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLR4</accession>
    <name>A0AAD2CLR4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000524">
        <property type="protein sequence ID" value="CAJ1935898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1273"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2089"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="695"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="819"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="898"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1297"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1338"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2148" mass="235862" checksum="51AB446DB8AE2BF7" modified="2024-05-29" version="1">MASTLESFYSWTLPSPRVLSSLQEDDDISDASEYSSDDSEDHDSDDSNTESEEDLDDENDEPVQIARKLLFDCWKQDHSPAMGNLYDGGLGTYFVLMEYAQRRTNRKLKLRQRKRQRRKQPTNGMQTPKRHTLGGIGTSSPRGSVTPRSSSNSAPPNKAFFNSPPRKKRTSIYRSKHYLKQACDAAEKACQSYHQTMSTVTTSFMYQKQNNISIFQSEWVGARALYGVCLYHLEQEHVEPDPLSTGQTRLSLSSVKPTTSTPDRTSIASDSIQQDGEEKTSRAKSILDDLVEEMLEKASHERSNTVLSGRAGALQAIFWIRSQLRDPYWSQEAVVELAKQIVQGGILTVNTEATVTTEDTTHTSGPESPSTSSGLPGRQSYRHGNFRPPKLPKSDVTREGAIMGQIGILHTLLNLTAQEWNLIEEQVPGSKQMVHGKLDSLTVPLLPSKHPKDTPEHCTNWAHGATSLAFLWIQASQVFQSKSYLLEALDICDNIIWPKISGDDDDSDSEGVNNSASKTTRPPPMGLAKGTTGMAFLFLALSEYCPKPVSTLWLRRAEFLARMALEHSSLATSLAPTPMDMDHLSTVFPFDRTKQSNKQGFPLDAKDRYSLYHGQGGLATLLLQLQRPDHKVHMPLYSMGYSEQLLQPEDQLPQVKLVLDDIPDEPVFAEPAERSKEPEPVIEEEDLQVETQEEVEVVESESEEKEESLDDMLDEILDDNKETEKEEVVKEFVKPRPSAKAILPRPSFLMPKFQAQSNNSLFWSLQSDSNIGDSETYRPSLVNTAPDSAEKVQLRSYSQTNSRLSGMSLSEAAAAMTDAAKDPKAKVTKREEIKKRTKESAQPSDATRIQNIVPSDGSKVIVQETKNSEQEKKTVAAPSPSRADKEETQPKDSKLSKKSTPSRSKQNTEPPIKSSEVSHSSGTQRDSASTVHSNLGNLSAMKDTDNSGLIKTTKECSTKESPGKCSSHTKGVLLETPKRNTFPSLSAQQEMASTPQHQPTSVFERLATPLQKAKQNPKATPGHKIHRTRDSVPGSGGKVRMTRSGMLQQQAMLSAASKDVVLPMDGKMTLISSEDPPRDFVTPCRQRTSMQTTTQTLVGPGATVRMTRAAMLNQKVATPVKKGEGETPPKAKYRHSPLSRAFQIHSTKETLPGSSGKVRLTRSLMLKQQVLSAKTKGNQESSRSRDRQSEPMGALGSKVRLTRAAILKQQQTAPNTRQSWQGSLRGSGSNSEVSNHSSGLRKNPLKISTEKLPGAGPQVRLTRSAQLKMKALKPEVQQAMEDHRESRKPHPPLNLIYVSSNSSTTSILGDETSHPNERSQRSGFKKTKSPIACTARNQKPHQSKKKVAQVSQALKDEPSSMSAINGPRDIGIEEEILDDILDNILDDDEHATDAATETKASKEAERLAACINAEREAAEFQVEEEKEVTATVSTEKKDAELKAKQAAEAVRIAAEAQRMKAEKEAAELKAKQEAEAAAEAKRMKAEKEAAELKAKQAAEAVRIAAEAKRMKAEKEAAELKAKQETEAVRIAAEAERMKAEKEAAELEAKQAAEAVRIAAEAERMKAEKEAAELKAKQEAEAVRIAAEAERRKAEKEAAELKAKQEAEAVRIAAEAERRKAEKEAAELKAKQAAEAVRIAAEAERMKAEKEAAELKEEEEYAARIKAEAVASRIIAKTKAAEEAEFAHLNAGREGELVVKGEEAARVDAGKAEAAHIKAGLEDAEVKAMEEATAARVAAEKNSIEACMKAKKEAAEFKIEKEEATEIADKMKVTEEAQVAVSTHDATEAIAECKEDRVTIFLGDFVPVLVSEDGKPEERTLVKGASMVEEAPPITKQVNLFQDEWDNDSFVTESLRGFLDNANSKLEADLSDILSDGVVRNHSVERQTILSGGPVPVSDCDNQNEEKVLEDQNEVKGLEDEMPLEATKSEVLASKLADHELDQESDLAKAIISEADTTYPTGIILNEHQLTTACPTVAKLSASMAFGTLTMLPEEFLRVPDEKDEEEHEDLTPAESLESMLQCIDSSLFDEIAAITAVLGEDAILPRSRSTTSDVELLDELPSFVEGDEGMNVGPASSFDELFNGFSFNSDNQESYTGGGTSSKDAEVTSPQHGMSVAQIRRRKPVTEQAGSLDADTHSIPNRGGKKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMC8</accession>
    <name>A0AAD2CMC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Semialdehyde dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS5188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMC8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23935">
        <property type="entry name" value="AGPR_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17896">
        <property type="entry name" value="AGPR_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01110">
        <property type="entry name" value="ArgC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050085">
        <property type="entry name" value="AGPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010136">
        <property type="entry name" value="AGPR_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01851">
        <property type="entry name" value="argC_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338:SF10">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041940464" description="Semialdehyde dehydrogenase NAD-binding domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1936431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="356" mass="38365" checksum="7AD737D8429DC523" modified="2024-05-29" version="1">MKFSSALLFLASSSTAFGFSPSSSTTSFASPQSALFASYKVFIDGEAGTTGLQVRERLEKREDLEIISAPFELRKDEDTRKSLINEADAVILCLPDAASIEAASWVEADNDRTVIIDASTAFRVDKDWDYGFPELSKEQYTSLTKSKRIANPGCYPTGFIGLTRPLVDAGIIPKGTPLTVNAISGYSGGGKGLMEIFEGEDHEPWSGYGFSLAHKHLPEMAEYSLLGKKPIFQPQIGSFPQGMVVHVPLHYEWLKAGTTGQDIHDALTKHYEGSKFVSVMPLGEGAVKEAGLLERGGFLRPDTLANTNKMELFVFPNDDSGAVLLCARLDNLGKGASGAAVQNLNIALGIDETTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMP6</accession>
    <name>A0AAD2CMP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000780">
        <property type="protein sequence ID" value="CAJ1939356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="501" mass="55429" checksum="96D2B7E9B9FAF84D" modified="2024-05-29" version="1">MEDASAPIGKKTVPAKKKPVTKKKAVSTQPADIAEQEDSETSGEEQPAPHQLSTRINATPSIQCAAGDLCQLPHLPVDPQHHCRTCDIPMHNPDFCGKACDSDDPRNHLKYPGICHQCLNSKLAARPEHKSQSNAITKKKKAAAKQLPAVAKKATGSANCGILTAASQKTPSKANNTAVTLAANKKKTSSEKAKKTAACKKAPPTTNATVAKTIASKKTLSKIKVVKMKEAAPIIPNCTPLAFRIEEHENWIKELPEIPRSYLKQVNGRLYLFGNVIQCTNRKEGKYKIEFSHTNIAQTEMQAYALYKAMDLRKLLQEGPAGAQQTNVFPLSSSLEQALNTPLKSQENQGESILSDCECDTDEEEEGEEQEVRTRDYISTDLQLNLNFPSLRQYEPSNTEWMSGIKWDVGLNGEVTTDVPSPTNLASNKKSYIPGKFKAHFSSPLSSFLAFFPIEFWRLVVKRTNEYALWEKEFGERKLYEKWQPTDLPESPTCLLADSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNQ5</accession>
    <name>A0AAD2CNQ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000794">
        <property type="protein sequence ID" value="CAJ1939465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="279" mass="30968" checksum="152B543591537D04" modified="2024-05-29" version="1" fragment="single">ADGQCGSRKHHQAIDLALSKRLVWDLLILQRRSAGWISNDAKSCFDRVVHWVAVLAMMRLAITWNALRMMFDTLATSTHRVRTGFGDSEESFHPPSMVPFQGCGQGNGAGPPIWVSVSSVIIQMMTAMGFGFECLTAIDSQLITAQCFCFVDDTDVIEAGKSVEQSGEDICHSVQQAASTWAGGISATGGAINPEKSFWWLIDFVWDSREGKWRFRRTHQLLPDHSLQIPGLTGELEALRRLEPDEAEKTLGVMLAQLEDQQARVAHLKSIAKKWAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNZ9</accession>
    <name>A0AAD2CNZ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000835">
        <property type="protein sequence ID" value="CAJ1939711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="309" mass="33561" checksum="87033F8FFEA8548F" modified="2024-05-29" version="1">MPTAKKQKKKRTKEEIAEASPISSLKFYRLKYNVDPNKPVQKKVSRKGETEKQRKARLANDRQETRAKQREEEEQKMNNAPGTPGFAGYIPGQANFQDCMPGGKANFSRIKFAPNQSFGATNLNHGNGFGATNFNTTQHNAQGGQNLFSRHSSQGPPLHQILQTQAIMVLLDRRHLAAILVLASQNSNQFSGQTGGFQTPHGQSTVAHAGSDVLIATAGSNPLVFDFLAKQMERPQPAANSPSERPTPSQLFSTPSWSNPAGSARGGDGNTTVPMEEDQEDQAGAKRFTGAPPVFNNGNLKPSNTRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP14</accession>
    <name>A0AAD2CP14_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12140</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6734</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000846">
        <property type="protein sequence ID" value="CAJ1939779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1949526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="733" mass="82542" checksum="DE8F561E65AA202A" modified="2024-05-29" version="1">MSAEILHPNLGPPPPAKPQPKPKPKKRIPLISKAEYQEGVKRTKALITELGLKVSETHRTTIVGQNQDSHQIATVRAKAQTVDRYAKALKDFLEFCFFMEDYESAIILMRDHCPENPPPVSDDTAILFLRYKVQLLDETVLHHKSHVPVVSRGKPLKAVGSWTAVSTIGIFRSALSQIHKAYDTTRGSSRHKNGSYFLACKECRKLTLEQRQNNKSCGAHNGHCQAFGEGNVIESETFGQHFSMIEKYAQQHYMSKSSASFLPSQLRTIRDHCANDGSLAKLMQWCVIILGCRLYLRIDEVLSLETESFVPKYFVIKGKTVISLCVKIKGKCDGQERHFQVYDDPKYPELSPVRPLLLYIAATKRTGGFLFPKSTQMFDANPTAKYYYGSFLTHIEFFVKLVGMDLQSGMDGEHLIAGTHMLRKTAFLLAYWAIKLEQLQSDKESIPTSIPSHEESAIFNDAAMKISGQSTNVTLLADGRHGSLSVQMTYLGDAATLFGLFRQLNRLSTNEMVGPYFPIFIKQLGNLLHIANNGSGTCGFNKKSLPELASWFVFDLMQVDSETDLARNIPELCRKAKALNHVEKEVSTEILLNKLKKHLPPELFTQAMTRMTSLPTKSGDTTMTDSDVTTNTIPPATLQSSLPNYQELCRKAKTNEAKLSIVIQAFTRMTKPPPKKTHLKANRWYYHQIRTYRCVQGCFNGNTCEFLQKCKEKGIQNVTGRIFKCPNKCVHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP89</accession>
    <name>A0AAD2CP89_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS2624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000191">
        <property type="protein sequence ID" value="CAJ1931952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="837"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="935"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1088"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1164"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="843"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="877"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1095"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1171"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1196"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1206"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1249"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1931952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1418" mass="159518" checksum="1C640C8D1DBA0E24" modified="2024-05-29" version="1">MASQFAAPQQEEIFHVYGGNDFQYSNFEYNPNNHYKDERNGRASVPNYMKPTQASRRRAKSADARPQYRNTSSTSSSSKSRALEQQKSYEDRLLDELLEQQFDLEHQQDIDVQRLPPQQQATTTTTQTTTTYQGPQMQLPTQDGDHFMDPNLEEPTERIHFEREMHNPFSSGGAKRLEQPLDRQTPKYSKEETEEEFFNPFGGEWSPEDDKRRWDMPYEPSSSTYPAPNNPATQQQKVQGTRSFPDTSPTYPTPTNSSSQTQSVHGTKSFPSSSRKSSSTASKSQKSQHTGGDWRSTVMKSTMVLKPKTKAVKEQVKAITNKLSSAMSSARSRSQIPTYSKSSQPRSKSQPPPARKNRGQYVADSGIMRRQQQNNNPIPTTNATPRSKDDYGSFDVEYDFYGDGFAQSRTFSHDGSQSDHGFRVIRPERPRNPQMQIKPDAVAPSYTSKRPAPVSYSQYLATSKIPSTKGGAFSKVSPTSVMDSIQNNSNVHWSNRLEPASTPRTIEDNPQSILRKRYPGSINDHDYLIEPTPVDFRDGSGMSLSPIENRTSPAQPQHQNMRTAQPAKSADESDLMSIAYSEFIESVAAVVIQTTVRRFLAKLLVDKLRVQVAAARKYRYNRKRIEGKTITPRPVKVPSVQRTSVQSRSRNRVQQLQQEEESMANTGMEYQLFVFAAIRIQSVFRGWFVRDIIKIEHYCATIIQKNARGLVYRNQYQYDLFRIIMAQSVVRRFLVCRDLYVVAPDPEVRRVLDFAAAMIQARWRGFVAEMRYFQNYRDVLLVQSVVRRWLAIRLVRAIQSLDQHQQKKSTGNNRFGKYGARHSLGNVRVHAHEPVPVVPVQPKSTGTHTSSKWSNTRNVPWQQPSSSSNTTITHSASTEERGSTTSQAKHDVPTGMGSIAKRRAMFESKRLNTVQQEDASKEKAAAAKAELKAMQRKVGVRPSPGTQSISSHPQRAKSMSGRIQNPLSKKNWGPDFRPNTKVVGRVSTFESSSGSVVASDVETEVQSNRTSTSRLLQGWRDREKSNSFDQRNSFDMTSERATTTATEYHGRSSNTRLSTGTIGLSKYLGGKTEHQEAVAPLSHGGGMVHRPPNPSHEQCSNPNSDPEPSFQDIMRSKRSPKESIRIQQIEEVFIKVGLMRPVNRPLLNANVGQPQPSKVERTYLSSPLRKVNNTKVEQSPSGTQAMKNQLPWRVQPSRSLDSSSPKTERKLFHDEPDSGNDNGNSSNEQAQSQAALKIWRNARQPPHANSNSNSNSSRAQQLPPRQQQQQSSGVERRSLGGVGVGANPSPVNERSKNLLNSLGINTSYTSEVSTDVSDMENSPSPAFLRRFQKVTPDSPVPKTNLFGAPEVQSQNKVVSTVNQNHPQRPVFSQFQIQKQAERSQEDQIKIDAMHAVFEKVGLMKSVASIYLYTVVDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPB5</accession>
    <name>A0AAD2CPB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001056">
        <property type="protein sequence ID" value="CAJ1941652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPB5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="505" mass="56398" checksum="70155FE88442E916" modified="2024-05-29" version="1" fragment="single">ALDFESVPLIGREKEVSTLKTCFSRMIETSSNEKNNTFESRKELVLVAGKSGSGKTAVTRTLEKEVLKHTKGIFVQGKFDMNTSSEPYSGICRAFGSLCLKIKEAPAEVLCTVQACINEQLGNDVDLLLHLIPELGDLISVTANDSAVKDLGADEIESKVERLRFAFRVLMRAFSSAASPIVLFLDDLQWSEVSSLQVLDFLMTDAQNENPLMIIGCYRSDEVDENSLLHNKIVALQEMTDKYKFHLTEIKVGHFGINEIDEIIATTLPNPSMDATLDLAAICLKRTLGNPFFVLEFLKMLHQEGLLQCDNNSNSWTWDVDKIDGATMSTANVVAMLHDQMTKLPHQVQALLQCAAYIGSTFTESTINLVWTTYGRRLVESKLELTAALLHFILKEQILEKADNNTFRWVHDKLQEAALSLTGKRRESFQLDIGRTLYYGLDKQQVEVELFTIVDLINNGNVLRLTEFASANLRAAEKARDLSAFQSAAEYAAHGIGLLKNDKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPU6</accession>
    <name>A0AAD2CPU6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026350">
        <property type="entry name" value="GxxExxY"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04256">
        <property type="entry name" value="GxxExxY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13366">
        <property type="entry name" value="PDDEXK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1932699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="258" mass="28585" checksum="2121C849532035E8" modified="2024-05-29" version="1">MVKPKPQPCTLALPPVALDEQNQSHQTATTPIISNLAGFQRELPLICQRIFQALGSQQSEATYQRCLSIDLLDAGVAKVHLEVELPLTYKGVIVSCRRSDMIVELACGGRALLEFKAVNKMTVDHRKQTEYYLHHSDIDDGYLINFPHDTGFPNVTDKSSFEYSGLAGITEQLNSVVLGGPVLRLRNDPKNREVEVVHILRRNKVIDAKKEGKIPPTKVTAAPLPTLGLTKKGLPCKNCKKENRLCRIHKSQAVGCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ82</accession>
    <name>A0AAD2CQ82_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000791">
        <property type="protein sequence ID" value="CAJ1939452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="271" mass="30310" checksum="E8011AFEBC3FC727" modified="2024-05-29" version="1">MSDGSNTAGDSTMYILGIPDSALVPIDDETYPSIYWKSFQSGDEFWLTAAIDVPSCSIISTGTGPPTVYAQLESSQEAFLYDPRVILQENTLDNPILDGGRSLVLETNCIANCANAPRTFLNEDHCVLSTAETACQASEVLEIEIELSEEFIKVSNEITGRYIYAVDNLPINDESYRDTDNQLQYYNEPPRNPSRWMLVDASICQNPNYRTVGLRTQTVFGNLLQRSSSSADSWLEDVLFFRGLFCDEDDNDKRSLGLIRDGDGHCWQHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRX3</accession>
    <name>A0AAD2CRX3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="339" mass="37091" checksum="5962C8CD64F685FB" modified="2024-05-29" version="1">MAEKKGEDTSSESEVSDEEDDDLVLEGVITRNPDVSDSDDTSSSSSSSSGEDDDDDDDDDVKPPPSKKAKQQQKTTAATQSKRNKKEEPPAQNKKKQKKKPKEGPEVIQVDFTFCDMHEKYFHGLKTLLTGTSPVYAAQSSGLADMMIKNVSVGTVISTEADSDGEGTIYGYASVLNLTTYQEDPAIQAIKKICLDKCPAAHKAELQVVFSGKTKRPAGIYLQGRMVNLPLEIVEVLHQQLVLDMDWAVKNAEGVDRKSLDFGAFVRIAPAYKSGGATYFKYFDDEIFAQHAEFTFEIELPKTYDMDEAPFCVALVITKTGHRAGMESLSEMINGGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUJ6</accession>
    <name>A0AAD2CUJ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUJ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF11">
        <property type="entry name" value="OS06G0360300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="36"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="268" mass="29693" checksum="736A03AA287E010D" modified="2024-05-29" version="1">MIQTKKSYPLRIVVFFVIVVASSFAMPISSKVFIAGATGATGKHVVQQLLEKGNSVVAVTRSKDTMMGLIPQKDYGDRLQIHEASILDLSDDELKSLTKGCSAVVSCLGHRPTFDGLFGHPKRLVTDATKRLTAAMPSDSKFILMGTEAVQLPIDPKRTFLERSVLFLLRNLLPPHVDNEEVAAFLQEHKEINWSALRPTNLVDADEADGIYKIQEESSLPLFGSQAISRANVAHFMVELVTNESTYSQWKHKMPVIVEKESETKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV30</accession>
    <name>A0AAD2CV30_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS8833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV30"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="446"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1944329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="673" mass="76269" checksum="755108F06C01A6BE" modified="2024-05-29" version="1">MIEAGFDLELDPRNQACDVTTITSDGVHTSHLPDNQDPFACMRGGAPSKLDPIADGPPSTIGGLSTKEQNHDDIISEASPAGPDYRPSHNGDPASRHQVATIDDFSIGIEGGMPYLRPSKTVKEKFDQEQKRLNDELDQQLKAKGWMDPDVAKTCNKIAQQKFDQEKRRLWEELDQQLHENGLEEGLMDPDVALKYNQIAMHLVDEGKLEEAMEVFEHRLNIEKKIFRCDDHPEMASTFHNIGFVLSSQGKYKDAMEQYQRALEIKLKALGPDHFSTAITYHSIGNLLHKQGKYEDAMEQYQRALEIKLKALGPDHSSTASTYQEIGMVLFDQGKYDDAMEQYQRVLEIELKALGPDHSSTASTYEEIGNVLYYQGKYEEAMEQYQRALEIQLKALGPDHSKTARTYHEIGNVLNDQGKYEDAMEQYQRALEIQLKALGPDHSNTAATYHCIGKFLRDQGKYEEAMEQYQRALEIKLKALGPDHSNTAVTYYCIGNVLEYQGKYEDAMEQYQKTLAIDLKALGPSHTNIGLTYQTIGDVLQHQGKHDEAREQFQQALAILHNTLGKNHWRVAMLYNSMAKDSAQRGDQDSAMDLLKKAVETMLENAREDHPNLAKIYITMADVLLETRPSQLEEAVEYYDKALAIRVKVFGEGHKFVNEVWQKKSELPLLGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV43</accession>
    <name>A0AAD2CV43_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS10660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001710">
        <property type="protein sequence ID" value="CAJ1946519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV43"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38894">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38894:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1946519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="198" mass="21863" checksum="2D9E92855B63C21F" modified="2024-05-29" version="1">MSSTPSWLDHGADPSPPLQDESLDVPAADTPPPAEPSSFASADEKDLPTIILYMRLANMGAAVALVTISVLLMVSLPPLSSFVLAIYATCGGLLICCLETQLKFLRVIIAVNFGFLFNSVWRFIFYMVIASVSWSYDSIPGKVVAGVWIGIAIFNTYVLCRYPGYRRIREKIAEEEDKRIEARISKEVKRQAVKQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVU4</accession>
    <name>A0AAD2CVU4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="318" mass="35993" checksum="55D4B47D1107B73C" modified="2024-05-29" version="1">MFTVIYANQAHHNEPDTEQLPSSSPQTSTEFQEVPITKDESPHKSENSMSTASLTAMSNPSMAEEDVSWATLQVVGDDSSENDDGDSDDEDLDVQELLDMYDTIDTIQVGRELAETPSKIIKRPSSYNLKGEEKEVRFSTVQVREYPIVPGDNPSGDSGPPITIGWKPTREMEVSVDHNEQYGLYADEKALQNSDHSRIKRNVEGLHLSHLKRMCKLHHSGYSSKEIGAATKAADDERRKREETLKSLKNEKLNEYKETIKRAFRNATVARKAKKAEKEFLKPYIERSSKNRHSSIVNESGELPNAKTYEDDGGFWYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWD6</accession>
    <name>A0AAD2CWD6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001415">
        <property type="protein sequence ID" value="CAJ1945425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWD6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43331">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43331:SF1">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="101"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="185" mass="20414" checksum="99A220808A284D11" modified="2024-05-29" version="1" fragment="single">TAQRLHEAREWDGPLSVYVSPLMVPKDHVLARISSHGNAVAIASANMGTCSYLGPGAGRFPTANSVVADICRIADGQQGPAFPIEAPPHLELDLDYIAIFYIRIPFQDGLGIIKRVGELSEDCGVSIHSILQTPIMDRMSADFCVTTEECKVSQVEDLCEAINQQVDFCRAPCVYMPMMREIYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D183</accession>
    <name>A0AAD2D183_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS10357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D183"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1946216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="274" mass="29697" checksum="0E6B271C4872E80A" modified="2024-05-29" version="1">MMTPNRVAVVTGANKGIGYFIALQLGMSGLFSNIILGCRDVQRGTTAANQIQALVQSKADTKIEFSPLVIGDEATHSTFCEKMKKEFGKVDVLVNNAGFAYKGVDPTPFEGQTEKTLSINYFGLVDFTQKMLPLVRKGSDPRIVNVASMAGRLGQVSSELQKKFSEDSLTIDELNTLMNQFKSGVQAGTYKADGWSSSNYGMSKLGVIAATKIWARQEPTIKINACCPGYCATDMSSHKGSRSAQDGAKNAVIPATTENPPTGEFFRDYEISTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBF6</accession>
    <name>A0AAD2FBF6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1922541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBF6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="88"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1922541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="275" mass="30459" checksum="27FE1DDF03F02241" modified="2024-05-29" version="1">MSNTFLPAISEEPSKSFMDEDVFDENEFLETENENEGLVTPTKTKPDEALSTPQAPKKKPAMKKSIANAQNASNSVDPVQVGLPSKFDVLCGQSRICANHTGNCRFQVVLDIYASRYEAAKSKQEKMMLTKEIVGCIATSGGRFLKYKDGLWNEISSVTARDKVSHALRTKVQTRKKQQTAKPSSSAKKKGSTRKGRHCRRRSAPASSAHTNDLSEVRAVSFDGSDGSSTSSNAIMDDLLRAQREIFEQLTKGDKQTNTPRKTNQHPLKRTETWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDC1</accession>
    <name>A0AAD2FDC1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000247">
        <property type="protein sequence ID" value="CAJ1933197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDC1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13246" checksum="50D4C829E54A8F09" modified="2024-05-29" version="1">MAYHRYLDSGAFAYAIGNVAVEASGVEGEQCLDDSIVDVIGETPRPTPNPTPGLTANPTSSPTPNPAPEQTANPTPKPTSWPTFFSTPGPTPGPTFPPTPPPTPVVLYSVGRLFVVDDVFLYCKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE35</accession>
    <name>A0AAD2FE35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS4052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000369">
        <property type="protein sequence ID" value="CAJ1934713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE35"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1934713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="756" mass="83484" checksum="7533BACB8592F8AB" modified="2024-05-29" version="1">MPESCIVILDPSEYMRNGDYIPTRYEAQQDAARWLIADITTSSPENTVGVMAGTSVLVSTTNNIGQLFEAVKSSRRKYTGEFEIENSLQVAFMALKHRRNKVGSQRIILFVGSPIMDHKSFPKLSKSLRKNNVSLQIVTLGDEPNQDKLELLIQNNSEDSRMINIPKGTVPSEFLSATSTFGTTNGFAGETSGGGMIDTFDPSMDPELAMALQISLQEEQTRQAQLQQNEEQREATTVEEDSVETSDVAAAPALSQIEADDDYKDEMAMMQQALAMSLQEEEDGRLQTEKEADPSSSSSVEMDNEPVIETKTTDEDSKVEPELVTIQDRAANSFKNDDSSRLGSSPENAISLVDIEESLSDSDDGKQFPSAVAATAAATAATMSSNKPLPPSMIINVEDEQDVQNDVWEDEPKRSFGEEDSATNEVWENEPRVSVVASSIDHYEAEAMLLASPPKSGGDEPKSYDDETKMALMMPATVPRDDNELPPPPSMPPPDVPQTTSSQESNWNQINQALDVYYTASSETNGRLEQHPVLGSNDETATHYRSSSLQSVGSSTLPVIRSCWSNLDQAFDEYNTAINEISTFLPAGGNSMTMPSSVPPAHFASMQRQGEEERQDNVPREEYQKLAAELDEAKKAMAIMHGIVNEKDEMIVALREIMGMMQQERRNLRNEAAPNDGNSETESEREMTDSLIQEIRKKNRNLEGLRMSLANYKTPSTTGEAPAPVSQSLTEKRRKKRELENLRASLSSQKRPTPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFC9</accession>
    <name>A0AAD2FFC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1906702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFC9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1906702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="394" mass="44036" checksum="778D6DD106FD7970" modified="2024-05-29" version="1">MKSGNYQQFGMNNLNNLKGFASKMREQARDAAKKLPSLDEMAAKDDYIHKEEFNVKGEKQEEEQQRNGERRIKKEENSSDTPTPWSLIDKRIFQNEASETPSIPSKPQSDEASFKSSLTEEEDIPLIVNDSPIETAPKKTRPLMMSVVTDAMTARPASPETCEVDDESSVASDSSSDSDSWNDEGDEEDDPILSMIRKSKVEDGAAQKTKKPKKSNSKTSKKQLAKEEKPKMHRFLADMADAENQMETNSQSNEEQTSISSISLSLPATPRELGSWMKNMASNQVNKILKRPDLSQSSTTTTSSAPPLASRWKSKLAAVIPMQEEYHSQDSADLLGDDELRQLASFKQSNSGGKLSTMMAAMYEYRQFAFILFTLILAGVVYFFKFSELEDGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGV0</accession>
    <name>A0AAD2FGV0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="345" mass="36389" checksum="BB3772480D814966" modified="2024-05-29" version="1">MAASNIREINIEENNDRASGMARRAEREQAEKHRARDRVTALRGQMQNGDDQVQNDNVEESKTIPRKCKIAILAVLMIAFVGGAVAIFGTIGSPSSSAAAAAAVTTDAPVSVIPTEAPTPLPSLTPTVASTLEVIYPKPSPQACAQVAAGQPVLGQRSLATRSFNVELDVSLAAETDIDTMVDALQIQTQDILIPSLVGCNERRGLRAIVLRQSTTQRRRYAIANAEATVVHDPSQTCVPTGSGPCYRVVTTLNVFIKNATESEQVLNNLIVGVYDVEALSVDLGIGALIDSISFEDILLAQQEPTNSPTRAPVSSPTVSPISAPTLPPAVSTLPQTPGPALTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIW8</accession>
    <name>A0AAD2FIW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS4198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000402">
        <property type="protein sequence ID" value="CAJ1934862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="9"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1934862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1108" mass="120943" checksum="E91D63421753174A" modified="2024-05-29" version="1">MASIFLPPDQTRLVTIAAHVDHGKTTLADSLIESNGIISERLAGTLRYLDFLDEERRRGITMRASAIGLKHRYLSPTKKQDSSTQKAPFLDLVVHLLDSPGHTDFSTEVSSSLQCCDGCLLVIDAVEGVCARTHQVIREAHLHELVPILVINKVDRLCTGLCLTPTEAYLRLRGLIETVNATCAAMLNSKQAEDKQDVTNNNNNKNSNNNNNNNNNSDTPMTPEEEHWTFEPSKGNVVFASALYGWGFTVPSLARSLFRSKTVSIKPVALKQCLFGDFKCKEGDKKVLKWKHDSSDDPLFAQYALQPIWEIYEGVATAAVSAGIGTSLFADGRILSNNNNNNNTSAGKQPSKIKADTPGMDQVLEIAQIGSTSKGTGTPMPSTYQEMDAVLAKIGASSEEAVLRLIMRRYRPLSNTVLDAVYEILPSPAMAASKVRSRALALANPKMEQEGMEPNPTATTALQEIRSAVEACNASVDVPAVAHICKFMAVDRSVIRDPQLGDEEKSVILGLSRVLSGTLKTGSDYYVMGPKHAKNVSSEEQKRQIRLYLLMGSSFLLVKEVPAGHLCAIQNLDDLQLKTATICESPYGMPLQGFDSGIRPLVKVNVESVDPADTYVLEHGLVKLSSADSAVEITATAKGERILACLGEIHLEQSILDLKNIYCERNIELRISDPIVEFGETTTWFEDELDFGNFLERSSAPLRQSTIPPYNEEEGLEFALHGRSRAILSGRAAAISLRVVPLPNSIYVALQSKKLVEEECKDDLLVMAKALGLNGANMDPSAIFEALSQSLCTSDESGNALVESKALIAGDTIKAVVSDAGEIHVAKKDVLVSPEEEPTVAPDTPATQAFKEVSSQIRKLGFEASSNPIEMDSNDSGAVEMWKKQMRHSAIAGFQMAVRAGPICEEPVRGILVVIEGVEVALTKSPDDESYKPAKLMTSGMVASAIRSGIRGALLTRPSRLLERHFRLTLHSSLEALGSLYSVLSRRRGKVLNDSMVDGTDLLEISAALPHAESFGLAPELFRQSSGQVTAPELVFSHWERLDEDPFWVPTSLEEREDFGENLQNGDISTGMSNIALNYIRKVRARKGLVVDSIRTVEAAEKQRTMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ49</accession>
    <name>A0AAD2FJ49_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000435">
        <property type="protein sequence ID" value="CAJ1934999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ49"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042110716" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="33688" checksum="5E4D358BF9636115" modified="2024-05-29" version="1">MKTCAFSAVVLLSASSASAFAPSSLLNKATSSNSNNSNNSNSNNSNNNPSSDVIVMHNVGSKWAYNPFGGTYQDLPPGRVSTDPAAADGFGSKWAYNPFGATYQDLPSAPTSSNPNDADGFGSKWAYNPFGATYQDLPSAPTSSNPNDADGFGSKWAYNPFGATYQDLPAAGPTSTDPTKWYFQPWSGVYQSQFTPLFTRGVDKWYFEPRSVIPPNDEFFHGYNSASHMWVPDQLYAEPQPFSAPAPAAPAPAALEASQQGAVPPTTTTTTAASAPPAQQEQQQQQAPPQMMPEPTPQKMPEDSTMSAYDKAMSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJZ2</accession>
    <name>A0AAD2FJZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS9817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF15">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="87"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="87"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1945672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="344" mass="38679" checksum="79DA26956C8C0F80" modified="2024-05-29" version="1">MNIPQPIESSAFPSFHESPLERAISKSIQTASPGIHQDRGWDALPMKKVKASKSICGTRKMKKSASKTIQKKETQGKKKWKKPKGKPNRPLSAYNLFFRKQRATMLGDDIPTPMMEILKKRVHCKTHGKIGFAEMAREIGRRWKSLDPESKKEFDDMAKEERQRYVIKLEEWKESLRAKEDTRALDTLSNAASSVSDSESIHSCEKSVDSTLEGARITSSTSLIVRSDPACGNETKRVPSRRAEPQSLTHMPTRVHAPLKPSPSYYERVAAGTTFPMASSFPVLHQDRLLLQQMLMNQAPALGANTTLQEQMLSGAIPPTASELAFLAQTQYRRQQMIAALFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL64</accession>
    <name>A0AAD2FL64_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000797">
        <property type="protein sequence ID" value="CAJ1939478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="508" mass="57084" checksum="8E403D0D79DE9879" modified="2024-05-29" version="1">MAAARIAWRNYIRDVLDFSQDEAQEIVIEQGFSSPAFFARSTRENIDSLVKQINRTVIDPGNDPDTTFSINQAQKIMLYDLCDYCRFIYMVDRQHDPAFGTQANLAKINRYYSHLKNKSNEFEDISEVMPPKFDNKNTVELMESLEQWLKRNRGKGGTLLTYVIREHQNPDDNPTADPGFLVPSVEDEAIRRSLHREDQFVANNKAVWNMLYSVCHGTDAWPVIKGYKTTENGRQAYLDLVAHYQGEGQLNKRRDSAYRVLNTTHYNGKKNFSFEKFAARVLGAFEDLKNCGDGMSEHAKVTKFLSMIKEGPQGAGLDACKTLVRGSQACMQNLRTAINTLQTEDTAQQTHRLTAISGTRALAAVDGGGRNSNRGRGRGRDRDNGGNGGRDRGGRNRNRNQHGRGGGRGRGGSRDHDGTIWSDDGTTILNNGGYSQDTWSRFSDRDRRVVLQARERANSRLMSERDIAELNSLREQNRDRQQSEEPAPSPAPAPSSGNVGSGVRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLC6</accession>
    <name>A0AAD2FLC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="633"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1670" mass="190604" checksum="9484253AD0DAFCA8" modified="2024-05-29" version="1">MSGLCHLHYVPESQGLTLDIWSAYKSVAETTLCEWACILQLGLYAAVIWYLYSSLKYRNDSVLFRGLDDEYIQPDQHLKRKCQSWKQSIPRWGLRPSGVLYALVAPPSMPRVGCRPSGVLFAHGEAYVNVHQPRRMYVELPSVEKPRRKITVELPSAYPWWCGIRRYRYPRQYHLRLRIARVKGDPRKILRRQRKEGVREQKQERKRQERRRKEDYESRRPERRRKGAAQGRKKTRFRLLKKLVRAKSPKEQDVLQRELKSLKEEDFWGDYDVKQPSHWESPSDEELLEDYERTKNRYLHHSYLQYESQYGVVLDELLADFRPNTKHHAMKDVLSSTFLQPVSSLPRVTQALIAADDLVSDVSCADRLRSVYINVDSKGELPIVIDTGASFSLTPNLEDFVTKPIACGTKSLNGLSSITPVLGIGEVEWKIRDMHGTIKSIRVSAYYVPDTNIRLLSPQSYFQEHGKGEVCFDSFQVKMTLPDGDTLFFPYQAGNNLPMMLTANRLVDEAAHIITDEEEEFLPEDMSVFLNVAHENNANLTKAEKKLLLWHAKTGHANMNWLLKLCKWTKTEGHPVMGPLPAKKDEFKSCKSPKCAVCQLAKQRRRSPRSDAAQQQPGSKTGKQRKEKEMMVDNLKPGDKVSIDQYLSAVPGRLAHTFGEEKTSKQYVGGTLFVDHATGFVHAKHQTSTGTRETVKSKHSFESEVGEYGHKVKSYRADNHPFSSKGFLDDIESHKQTIDYSAVGAKHQNGVAERAIQTITTWARAMLLHQMLHWPDEADHKLWPFAMDHAVYLWNHLPREDTKQAPIELMGGAKIDHHQWFKRLHVWGSPVYVLDPRLQDGKKIPKWDVRARRGMYVGVSPTHSSLVSRVLNLQTGYVSPQYHVVIDDLFTTVPNADQGGLFDVAEFDATTWQSLVETGYEKHLDEEGLASGSRHDRRKRPTLANEWLNPVEKRARKSRRAAREARLRQRIAEERRHRAARNRHVTFEVPEGGNIDAEDKPASAPPNPPSHDDLNDDDSDGEPAIHSDDEQSVVEGHEAEDEDPGEESESEGAAAPSLPTSRVRKKNPKYFGDDFANVAELGKKKIRHSALDRQFFANLKWAEAINTIKGDNFGRMWRAACEPYHDHDTGLQDDLHPMILAAKANSEDNPNWNEAMNGPLRQGYWKAAEDEIEALKKKESWDVVDRTEGMNVLPSTWAFKCKRYPDGSVRKLKARFCVRGDRQIQDVDFHETWAPVVNWNTVRLMLILSQVLGLSTKQVDYTTAFLHAPIEEEVYVAMPRGFSEPNKVLKLKRCLYGLKQSPRNFFQFLQSNLEDIGFEPQTEVDPCLFISKNCICLVYVDDTLFFSPEQKYIDEAIAKLREKGMELEEEASVAGFLGVHIERNEETGAITLTQKGLIKRIVDALGVQKTSPTPAHVDPLAIDAEGDLPDGLYNYASVVGMLLYLSGHSRPDICFAVSQVARFIHGNRRSHEVAIERIGQYLKGTMDIGLILTPREDFDIDCYVDADFAGLWNVEEHTNPESVRSRAGYAICICGCPIIWKSQLMRPIAASTMEAEYNALALSMRDVLPLQELFKTIGHAVGIGKEFCTQFSTTIHEDNQGAQKLACMEPGHHTPRSKSFWVRSHWFRQYLKPTRTKVVYIKTNLQKADILTKGLTKDKFLRCRKLLCGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLG2</accession>
    <name>A0AAD2FLG2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000957">
        <property type="protein sequence ID" value="CAJ1940781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLG2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="24396" checksum="266E8413AA3E19EF" modified="2024-05-29" version="1">MIKKKQRETKRKPLANKAKAVKLSKYATKNPPPSLQDLIEKMTIRSRSRPAELENPATVPFDMLLAADNILSRTEAGGALHPPLIPPVPETHGQHRSVVGSPNNQTTRNHGAITRPCFVIPSHGAKKNAPKTNGETSASVHSIPFVLDDPSASNYQPLKPRAAVSTPTHAANHNDGSSECRPIPPPPRLPSVPIGFAFSSSGTLSSLSSFSSVSRKSSARARSTVSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLH3</accession>
    <name>A0AAD2FLH3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000990">
        <property type="protein sequence ID" value="CAJ1940981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLH3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="16487" checksum="41EEB01343177427" modified="2024-05-29" version="1">MIVSRSGKVVDVCGYDPSTTSRQLEVVTAAIAYDRPTTGETIILVLHQAIHVPNMDHHLLSTMQSRTNDVTINDRPKFLTACPNDNDHCILAPSDNPNDITRLPLRIHGTISYLNVRKPTAAEYANCEHVSLTADAPDWDPPHHQIPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLH5</accession>
    <name>A0AAD2FLH5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000997">
        <property type="protein sequence ID" value="CAJ1941017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="161"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="382" mass="42769" checksum="DC988DF8AA9EFAB0" modified="2024-05-29" version="1" fragment="single">PPNHHPNSITIYILTNFELGAIVSGYLCAQIHGDETEWIDLKTAKEAYPIQVAEYAVANKLVSEPAFSWWVPYTLKKRDRILKAVKRRALTRKTEKFGLELPGTGPKGVRRAYKIDANTGSNHWGNAIEKEVKTVLPALRILGPNEPVSPGYTCIDLMTVFDVKMDLTRKARICARGDQTDPPLSVTYASVVTRESICIGFLLALLNGLDILSADIAGAYLNAPCAEKIYTVLGPEFGDLEGRTAVVEKALYGLKSSGFSWRSTLSKTLREEMEFEQCRGDMDVWRKPALKSNGEKYYEYIFVYTDDLMAVSENPRAILEKLGTHYMLKPDSIAEPTTFLGATISKRFVDPSDSNPNPNPNLTSKIQLEFEKKRVCCLTFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLN8</accession>
    <name>A0AAD2FLN8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C19 ubiquitin carboxyl-terminal hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLN8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C19 ubiquitin carboxyl-terminal hydrolase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="407" mass="45491" checksum="F17FEBD9D272E714" modified="2024-05-29" version="1">MAPKQIFFRKLDATENGSSSFLSALQLIAHIVTPIRKGMIHFFLQNRNTSMDQIEWIFLRELGWLFQAMIAAPPDSGKKEANDDEDEEDNSPPVDPTAFFDALKPCLTKYKKKTTPKDASQAVQILLETIQACTSTLPVTGELWNSMLDEASLRFVARQTIVGKTELEDGEVLQRTKKESLILACPYVIPKSAGAKVEESTSVDKLLKEWCAKQPHEYDFDDKSFDFEVTIPVFSKGDASSDGWSVNRTLHFDALNGFLFVGLSRLNDQGEPSETEIEFPKKLDLSKLCTSDVTGSKEFELYGGVLYDDGDYVAALKNSAIKDPEEEGAWQLMESDEIIPMEEGDILEFLKGEGGEGPCGTLAVYRSCNKSIHKQMDNILSDIIISHVSGVLNTKSEQYYYEEVVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLP8</accession>
    <name>A0AAD2FLP8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLP8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1942252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="224" mass="25912" checksum="45BAB8D2887BC7DB" modified="2024-05-29" version="1">MCTRQQTIQLASTVPSKLETARSTVSSTMKKSSVYFSETVKVRYSLSLEDYSDEEYDACWYSSEEYQTIEKDLCRQFMKMEEGKILHDMKSCSRGLERYLTVNAFQKKESQRVARRSVLDEQTHQAELNQRDEEAIARLYNNVSSSCQMWAAVLGLRDQREAEKYIQDDDLETRFDDLETLTQAQESQESSIRQDYVAPQKIYDSSSTRAMTSPQQMAVTARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM95</accession>
    <name>A0AAD2FM95_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12935</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9334</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM95"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="474" mass="53493" checksum="BB2F7D540FFB223E" modified="2024-05-29" version="1">MLYRQSSLGLRCDHRRAIPERVGEEIVSVNNNAHKIEKEDSNKSLLKPSTMPPISAAAVSSLEEGAGKKLADWEIHFQLQSIEEHNLDRRNFVPIQLWNTNKTMFGEKGSITRKRYSRFINNTVKRVGIETYIKLLKKHKIEMSDTTRAELESNEENPVDADERMETEETEEDKPTTEQRDVPAPEQRTAVSSTIPEQATALNSSFDLLVSNLSGMNISANSSIGSPSQIFGATSYGSHSFSSPCGFGSPPTRTRPSYPLPDYHQDGSKKWPNVIYNFPEHGHRHGNTFICQGLIEQDHIEYQTITVNCPCPPDDYKFYELKIANSFEVPACFQKHLGHILLFREPVANFTACQYQKFGIAKSDNPGAKKTVVNALKAEAVNAERDLDLFFNYSIIVFSMEQPVFANRIFSPKSDFIVDSEKSGIHNKPEDNTSFKKDQYGLTLSWKIALAGEFRELKSSVEEPDADSFFTMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMI4</accession>
    <name>A0AAD2FMI4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS9949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001524">
        <property type="protein sequence ID" value="CAJ1945806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMI4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042214494" evidence="7">
        <location>
            <begin position="25"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="663"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1945806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="695" mass="76004" checksum="22646AD8CF6D7642" modified="2024-05-29" version="1">MKQSLLVRSFRLLALVCLITPNSAAIFGIRKNENLLSRIHSLRGGADDKISGPCIGIDLGTTYSCVAVWRNNRVDVCPNEQGNRITPSYVAFLKDGTRLVGDAAKNQASQNPAGTFFDVKRLIGRNYNDQTVQMDKKLFPYAIVDDKHGKPIVELEKPLASKHIKSQFTPEEISGMILRKMKETAEAYLGEEVKHAVVTVPAYFTDAQRQATKDAGTIAGLKVERVINEPTAAAIAYGLDKQDREENILVFDLGGGTFDVTLLSIDNGVFEVRATSGNTHLGGEDFDQRLMEFCISQFKRRSNIDIKDDKRAMQRLRKQCETAKRTLSTQTSATIDCEALAQGEDFSGTISRAKFEELNLDLFKKTMAPVTQVLKDAQMSKADVDQVILVGGSTRIPKIQQLLSDFFGGKTLNKSINPDEAVAYGAAVQGGILSGDAAEATKDVLLLDVAPLSLGIETAGGVMTALITRGTTIPVKKSQVFSTYADNQPGVNIQVFEGERSMTKSNRLLGQFELAGIPPAPRGVPQIEVSFDVDANGILSISAHDKGTGKQESLTITSEKGRLSDEEIDQMVHEAEEFAEQDANEKAKVQARNDLEAYLYNLKNSINDTLAGKLNGDEKTALTTAIDDALVWIEDNPAADKKNYDDKQKEVEQIANPILKRAYESASAENSEMDDDFLEEDLDGVDDGPTVEEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPV2</accession>
    <name>A0AAD2FPV2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1948961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPV2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="273" mass="30635" checksum="33A1519F8A6D955E" modified="2024-05-29" version="1">MSRKGDSVTSAISCHSHSRRTASAVSWPDRQDIANLKSTVMKTKMPRIQTMMDEHLNRVSTEVLFISDEEEDHDDTDVNTSEVDSEGQFSDGSDDDHEDDCDRINELIAEIEEAKLKKLKAEKARLEAKKAASQSPRKKKLTPTRKKTRATSQRKVPIAKKRTLKGTTPKQVTIEEGNNTLNSPPQPPTTARILKPESAAAETQNNQPILQSVLEAIHPYFVKLQDSADKMSNAARRMEQEREEARLRMSAINMGQEQPHPSGPTLQYPLKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ76</accession>
    <name>A0AAD2FQ76_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inward rectifier potassium channel C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS11815</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1948881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ76"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="13">
        <location>
            <begin position="198"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1948881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="382" mass="43368" checksum="FEC3B6057A952FAF" modified="2024-05-29" version="1">MSRRTSMIDAMKLRSTRNMESFLHSASELSNHDNDIEKPAEKKRCVDIDGHKVIFTLVKNETQRPKASRKERQEFEITNKNVKLPGNCHERKIRRFLLTFDIPALTVMYLVSFVVMNACFAGLWSIESDGCCGDGSMTFWQHFDFAVQTSSTIGYGGYWPRGYWNNTLVVLLTAFSILFSTVYAGLVFFKFITPEANIEFSEVMTLSNVMGQSCIEIRVGNVDASSNKLINAEASLTVVSHQEYQSEDEGDKVLKISQPEDLKLAVTSQHLFFGVWTLRHFIDETSPLYGFRFDEFPGSTIIGFQLNIKAIQSLTKGEVYAQTRYQVEDLLVGHAFEDQAIWETAIQTAVFDYDKMSSTRPSFVWYPQKKDILDCGDAVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR59</accession>
    <name>A0AAD2FR59_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS12418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR59"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1950092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49877" checksum="4A7331FDACAD1E38" modified="2024-05-29" version="1">MAEPSSTYLYVPSEDEQKAISILLVLSASLSLVGSSCIVYHVRHNSKSTPYRRIMLGMSACDIVSTIGYALQPYVGLKGESNSFVWSFGNAASCSFIGALAQFGFSAHLYSAALSYYFLSTIRYGTREAVFAKKYERWIHVAIILWSVATAIVGIALDIFHLNDLGPGCWVSGTPDCTGVRCWAELIAWVMGGIPTLLSFFSILINNLKLYCFVRQTVREGQRRALEKESQMISYRLNNHQQVQDNVPMDTSNHNKETRSMKRQSSVLTSSEKQWKRVREVGRQSFLYVGAYLLSFLWTIIKQALDGQDFERSPGSGTFLLPLSILQAIFLPAQGLLNALIFFRPKYKQARKLYGEQPRLWLARRAVLGGNLRSMETNTLDPMSRRTTGGSRAPVSQRSVSASVVVGQKRVNFAGEVVSRCSNPMLDVPQNEALPAEGEHQSTPSEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRD8</accession>
    <name>A0AAD2FRD8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12575</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16991</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001766">
        <property type="protein sequence ID" value="CAJ1950418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001960">
        <property type="protein sequence ID" value="CAJ1958018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="99" mass="10893" checksum="207AC8AACEF8388C" modified="2024-05-29" version="1">MKCFESGGVYDPAVRNGRGRKPNIEPGSIAETAIANMVETGSSIEIATDLLNRDLKEKHEKDPVLGPLVQYTVSSVYTWVKNLKPKVSKIMPCKTAMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRQ4</accession>
    <name>A0AAD2FRQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001762">
        <property type="protein sequence ID" value="CAJ1950334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="222"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="536" mass="60381" checksum="7F1B64DAD11A20D0" modified="2024-05-29" version="1">MNDMTHEDREQSYLEVHGIVDRFNETPTAVQEALEGMKAAIEKSTKKDALKLVESMDEAYINDSLLHLKFLRGEKFNIKKAAQKFVQHFELKMELFGESKLVKDIEQEDLDENDTKALYLGYVQWLPLRDISGRLMWELTQPTPRPEEQGDPASTEDLLKQIMLYYPEAIDTFPLDFATLSQAQNDDDQVQEKVQHGAYGTTAFGDHKMVNKIVNGDPRIVVPEALHDSTVHWYHVILGHCGQDRLIKSLQNHLHFPGLGAKVKAFVETCDECQRYKNNGPGYCHLPPHDDYPAPFEDVALDHDGPWTLDVSEFGKLVFHALTPIMDIASDLLELLIYNAAGSFTAPTFQLALNCNGITGVPITVKNLQSNTIVERSHATIDNMLRSYQTANIPDNVGTAFEVIDTVFASVQRAMRTAVNKSLGASPGAAIVFRRDMLLNVPAIVDLEQASDRRQAVAIGNNVTENKRRRYKNYNIGDEVLILAHKPHKIIMGARATGPFTITTQVHVNGTVTIQRRNNVTELISIRRLKPYNRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSA6</accession>
    <name>A0AAD2FSA6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001783">
        <property type="protein sequence ID" value="CAJ1951492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="117" mass="12938" checksum="2EAFD0F3D56D4CF4" modified="2024-05-29" version="1" fragment="single">MSLYRGTCWKTLSTWKKGWGECVFLLPIELAKVRRAESQEGQEPTFAMELTHRGGLSSTQEAWTKEGAVAALDPTSAAPWRPFRFFSPEAAAGEIAFCNFKASCRRSCGGVMELEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSS4</accession>
    <name>A0AAD2FSS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSS4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041934209" description="Fe2OG dioxygenase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50600" checksum="E6F81D70508AA72F" modified="2024-05-29" version="1">MRQSQREVWLVLLSMPVVCCMVTQQDVMAELLNQHQLESDYGFFVFGDSTIADETKQRKWMPSDFNNFSLGEGSAGPSESVLKQASSVFISKEPIISEEECLALIEDAKVAIASGRRSTEEGSESTRASRTNSDLNEARLSQLPTRRPWLQKLLHEKVFPILESKFGVPAESMTLNDGLVLGYIAPSKSQPIHRDASLLTLQIALSPQELFTEGGTYIEGLHESLQVPMGHAMCHCSGTMHAGKGITSGERWVLVMFVLGRDEPQYARRLHSHGVSAMDDSNYPLAESSFQTGIEIAPTDQLLRLSLANCYLAQNKNSAARKQLRLAQSYKHCVRPFFLHANQLVVKSRPRAALRRLDMALERLGDRDLSPSAWNPMRALGWEIRVLAARCACLCAEKELVSSRSEGNGDMPWSRQHLPKAIERLHIALQFAPGHEPLMQMEARARQLMSMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTE7</accession>
    <name>A0AAD2FTE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS13486</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041960241" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1952306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="203" mass="21642" checksum="377D1F5B1180BE00" modified="2024-05-29" version="1">MTPIPLLAVICAAFLVHTSNALSSNHIDRRQALSQATAASCAATIGIVLATPPAFAEDTATPTSPPIFQEGPGGIKYSILKEGTGDKALRAQKVYTKYTLWTGGFGDDGGKQVDSNTGFMGRPLGVIVGVGQVIKGWDLTLLEMKEGETRRIIVPSDLGYGDQGAGGSIPPKATLYFEMEVTNMDPLPNLNDEQKKWLEEHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV67</accession>
    <name>A0AAD2FV67_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS13977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV67"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041973850" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="8">
        <location>
            <begin position="271"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1953332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="736" mass="80888" checksum="ED7F017BE3FBAFF7" modified="2024-05-29" version="1">MAQIRSFIFLIIGWCSILPRPSSSAITSTKTGYDTLHGTDAICWESQIITSANIDDSTISSSVGSSIFNVEGLVNNSLSASRNDSYVMDILSSCPNGTWLQISAPQDLAPPAPLTNVEYNYTVQGTIYIASLPGLEIASDDPTKAKVLIETIACRVSSSFCSPFVDEQTEVALAGQLGASVELKDTHTNMGKLVLDLELSNSSIYTFNVQVPTLIEEDGLYNIIGVATFFVGSSSQPERRYDVANSLARERSNQYMVYSDPPIISKVEPQAYIIAYLLIGISAAILVTMITLTLKYYDSQVMQICQVPFLLTYQVAALMAVLSSILMEAKSDVYCNWSLPLIMIPVHVHNAITLGRLYRIHTVVSPLLSDHFTRASVQRFPIRLQMKVLSLCLHGKWQDGDDSKQIRRTIARLVIQPFELAFEYERDYSIGRPLCTAEILNQQENIHESLAVYSLIWLGFLGLTVLGMAYVSRGLPSILNESQAIFSSVIYSLLASLIIGIALYMTRTPDASPGLRFVMFVALVIVTVMVPTLRIVGPKLILAHAGMKIMLHQMISEHNNQHKPNAMRSSSRQSNHVHISGTSLTNPIGIPQSQGTQGNTTRAPTETLKEAHGDDETKESQSKNENSANSEDKSKRLGSLQAGMDGQNEQVLQDFESHVDEDSAVFIPAGNAPPNEILGKVVELQRRLDKITKRIAYGIAVPPEDWRLLSTLTGNLGSTLANAKFEEEEKCETNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVN8</accession>
    <name>A0AAD2FVN8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">subtilisin</fullName>
            <ecNumber evidence="7">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS14790</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVN8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041920735" description="subtilisin" evidence="11">
        <location>
            <begin position="42"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="181"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="421"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="509"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="594"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="728"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="603"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1954195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="764" mass="81362" checksum="0E0EC63402C38218" modified="2024-05-29" version="1">MSSSSSSSSSSTATMTMSLPSLLRACLLISCLSLVTSTASAQEDDGKISVLVGFKTQEATQQFVSSYQEVAVTASVGDSGEATEIKSSGGPQIQYEYENAQALEVRVTQKEFEQMKEDDQFAYVEEDPIVYQMETPTSSASADIRRQLQAAEEPSYGLFSVQGDKDIPLPPSNAEDCLVDICIVDSGLIEDHFDIPYKRGDGFVDGEEFGLPSGQYWWNARPDDDHGTGVAGVMIARGGNNRGTVGVIPQGPEKSKVCLSIARVFADNSKSTATSRILRAVEWCGRRHRNGSAKRMVVNLSLGSPSRTTTEETVYRNLYREQGLLFMAASGNAGTNDYAYPASWDEVVSVASVDEGNGHSSFSQSNDQVELSAPGRQIISSGGGAGGTGSGLELDFGGTVVQAAFMQNNQYPSDFNFGQTFELVDCGFGFEPCQNANGKVCLMQRDGTFTFRDKVQNCQAGGGIMAIVYNNREGTFTGLIGDPNTVNIPALSMLQGAGDSVKQNINRSFTATNINGSVRGYTGTSFSTPYAAGVAAKIWASRPSCSNAQIREALQKTAVKLGNRIPNDDTGYGLIQTLDAYEYIVQNFDPPCGGVSLSDITPTNPPTPGPTPSPTPNPTPAPTPSPTPGPTPAPTPSPTPGPTPEPTPAPTPGPTDTCAAYLTQCVATEECCSGLECRRISADSTQPWVCRPTSKENRDKLPRAGYCIGGIIGSGCRRRTVRQGGMLRGEQHAAVEHRNLELAEDEPADTREQSPEEQEALPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXE5</accession>
    <name>A0AAD2FXE5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXE5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="2">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="642" mass="71077" checksum="1927AEB970473D08" modified="2024-05-29" version="1">MALTKLELEDSDDSSTETSSSKCQGVHDDLVIRELLMNGLNLSRVIGIYKGRLPEEDIVAIARKVLIEIGSKRDQEGQGDADDSEGGAGNGKINRNQHFCAIGIDILRRSPCDLLMGSELLKHHITNLSQSAPEDFFDPISSDIMRDPVVISSGFIVDRSTAIEEGSGNLKFATCPWSRVELDPKVYPALRLKQQMTEFKSGRVGEIIETASLLMNTKNERDFCKVIELAQEFMNDIGPKGHRTLAMQLAQLGLGALDKQPCSDTGLCILQPSLLTKQLLTLYAVKPENLMEAYLPGKVLQICKMAQKAIDTHQFDEAEKWLACCTELQDQCQDMLAGDKEIPVAEMYLNLAKKRGDDNLVPFQRRVYLGFLRNGKAVAAQQFLEEEGISAVELRDLSPCFFGRGTLSSSISNDRWNEGCRSSALEGEVSRVFVTADNLRDQGWGNAKGSLALALYSSNDELIARCNLFGTYRTEPYESKYPGAFAYRLLESDQEVVSKCTPGCYYKFEFIVGGGGGHRLELDSFICKIFYKEWFAQQQAPTGCYRMHDPEGDAGVFLGSVNQQGVAHGKGRLEYDDGITFVGTFADGLMLEGTNYQNGQAIHSMVGGRWTPGSDFGNPDETVVSRFPLDTHDIVETRDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXG3</accession>
    <name>A0AAD2FXG3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001902">
        <property type="protein sequence ID" value="CAJ1955896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXG3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="384" mass="43388" checksum="6F3C371E7E98D16D" modified="2024-05-29" version="1">MLQKPPFVHRKRRDALLMHPIFKKLLMKKLVSSRWPRCKLRFTELVLQVHAFLCTTQLGVGWNVCLPPSPHCFTSPKFAKGWKYRNSKAILKLDVDFVSLQSHDCPVVPPSNDKNNTAYASKTPAARRQYTNAQQSKGGQNNASRSHRGSFYSGEYVYKRGNGVDITSNSQVTKMKIVDTTQYKHGFINVTLPDGKITKIDFHCKGGMFPDETNALNDSCRQLGLMWEDNADMVREVRNDMIKVGMVSMCGGLNVKAPTLSMFGAKGLGVVKKMNIEARNLCAQMMPELLEEIYMRSPAKVPDEIGGQQGLCSIMFQSQNLENESHFDHSDLSRCFAIWTSADGKDHDGWYLVFPNIRYSESSPGVTYDGLSNRYVCTLFFIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXK6</accession>
    <name>A0AAD2FXK6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="567" mass="63701" checksum="8680ACFDEFD029E1" modified="2024-05-29" version="1">MSYHYFGNEDEALPQDVQHLIVEASVQVIPAEFSFFRFRRLTRVDLSDGIQTIGSLAFGWCNLLTRIVIPASVTVIEEGAFESCISLESVILVDGDDDPSCLVTIGERAFNCCEALEEITIPSSVKRIQDYAFRRCISLVQVSFREGLKVIGCGSFQECTSLERVNLPETVETLRSEAFRECSALWEVNLSEKLNEIRSRTFYGCSALSVVNMATNKRLVTGTGIFEQGDHQTPPSIYTGVKVIGEYAFCGCEGLTSIALPPSVTNVERGAFQDCSNLVSVELAQHSSTNVMSIEYFAFYCCVSLVNISMPVTTAEVAGFGSCTLLCEKYGAANLPNALMRRFDGYPIHRKCYHASATTADDLIREIQSNEGLVYGDDYKQALVDPFGMTPFHMLLSAANGANRADLLRILLFSFPPHVLGWKDSFGMLAVEYCWEYQWNEDARRLIRMILRRWMVGSIAGWGGLQSWKPHMSTFIELFLAEKDDEMSNTLFKYLQFKLAQLEVWEKISLLDLKLWKTEMTKHSDNDDMGGTITEYDRETCRIQCGTSVVLPNVFGFLFIEPTWAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYA3</accession>
    <name>A0AAD2FYA3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS16436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYA3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042289130" description="RING-type domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="284"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1956869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="335" mass="37345" checksum="9D18784CE79D7613" modified="2024-05-29" version="1">MMNLMKSLSLLLICLITVAHGQDGSSQQPSPSPTIMISPPTANDPPILTIPTSAPQSATNLTLAPEDPQDEYSTCTNDPDWSFSHQYVAGWAKVVEIRGCDDDSVKCCHEGNLGYAKDHCCKCKAADYECSGNPDDDGFPIALQVLTSVSFVFLTLFSFKMVRESELRHIRQTMAARRQQQRESNHTALTLEEMNIARYELFTSKFFFQEVMPDKSNITVDGLRRSSMKLGDDNLCDEENIKTEVVDGDDSVVPENSGPGIIINDQTLSGMLSSWRKPAAKEECCICLECYTIGEVICAPMKTECIHVFHKGCMHEWVRRGNDKCPLCRVEILKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZB3</accession>
    <name>A0AAD2FZB3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZB3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042113840" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53817" checksum="7A2F1D77DEBDADAA" modified="2024-05-29" version="1">MMIYRLLSTLALCSVSAVAFQVKRNNPLCYHGQALGKCQQSIRDTIMDPTISRDLDSFKSWTKENGVLLADGLDLSSSPDGDWFISLSKPINEAQVLMTIPKELRLSSTTIRDELGSDVGKAVEYLQSKKLDEQSHQFYLWIRILQEYEKGEASKWHGWMKSLPRTFNSAVSMDEEELECLPPFAWSLAKMVRLHHEAFLEAIKMIAEGVLSDETKADKEVLLWAFNVVFTRCWGKEDFDDKNRHDLVPMGDMFNHGDPPNTFIDYDEDTDECHIILKEDADPSTPLKLSYGHSRVPSKFLSIFGFVDESQTEIFCQMLVTNPTKKHVEIGYDTDKMLFDTRDGTIADAIFDVTLYSILEQVPELQEKFYRAHVDKDKETKGYLRQQYHLETCIMIKNHIDSSLKIFEDVLQKCVNLNPVEHPRLETIYKHNLFFHQTFHKAQGTINAMTKEEMMIRKERENSVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0K0</accession>
    <name>A0AAD2G0K0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS17627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0K0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="68"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1959206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="477" mass="52478" checksum="92E596654711C906" modified="2024-05-29" version="1">MLQNSPPDEPSSSSSSDVTNRRKSSKTTHEEKGLIRSVLEQEHFSDEEGSYHSDHDSHGQIGSARTPWYGTTVVLLSEVMGTGVLSLPFAARTLGWIWTLVAVPVFAVVAAYSGWLLAFVKREHKDFGSYADASTELLGNTFGAFTRACMLVNWGALAVYYMIALSNGIGDLFQGMCDYERTIIAAFLLVLPCQCRDFYNISKYLSVPSTLAIVLLLVTVMVNLSEDETEPFAQSTSLEPLPNTSLFDFLAALSAFVFAYQGQSIYLELMSEMKDSSQFPMACSSAYFCMCIVYAATVVVAYGVKGSSTPEFLPDSMQDGLAKRIAGALVILHIAVSYVICCQPLHDWLHSTIFPRTYHDESRLGSMHWFLITTGYLVFGFVVGNLIPFFADVQALIGSLFGAPTIFGWPAIFFAMIYRRKATSWQEAISLMGYGHAFVCGIFLFICTPLFCILGTTGAVQAIIEDSKEAMNPFQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1B0</accession>
    <name>A0AAD2G1B0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1B0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="152"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="226"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="315" mass="36579" checksum="F583977268AF331A" modified="2024-05-29" version="1">MNKESDGVMLEPTPFRDGTTLTPSSHFQGLYTVVVGSARQSDVSQLVGLVPPWNQTWSNQQPNQNQSQQYSHDSMATAGHILIRNSFLDALNERDSTHASSSLLNSTPSKTEAPLAYQSKRKRARRDQQIVGPNNGLKRDPNNLRYRSYQQGQWDLQFQELLKFKEMHGHCHVPHTYDHNPILARWAKRQRYQYTMKLEQKQSCLSDDRQQKLDEVGFIWDLQMMAWQERFNELVEYKRKHGDCNVPNRFGENLALGQWVKSQRRQFKLYGLDPSSSRLTPERHQLLTSLGFTQYYYHQRLVGSPNKNVKGANPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2X0</accession>
    <name>A0AAD2G2X0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2X0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="45"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="326" mass="37104" checksum="B41ED25274FB1EFD" modified="2024-05-29" version="1">MKVKGGGPPPSTDPSEWPHRPAYICAHPDVQTPHHKEGSPLPLDEIVEFETDLFQGKMICRLKPVPPTPDKDEAAIQAQEEYFASRNTHYQFIIQGRFKREIPFSDLVIGDFYERPMLGVPKGLFIRMYQRFLESLYPGMVMDMTSEKPKVFTPLASAQIMRVDLPGNEPNIHDKAVLQEMHSLEDTTLLFEHPIQPPTKLPRPGTTTSPSKRRGHLSKPKNACHYQTNPNHIYTIEWGDAAMCFGSYYQYAVGFKIDLAKSMNAQPLAFAIFTRQQEIVCKFPIWNERLIDEMKAAETITEESPEDDPSDSVVVDRPDSVWQSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G317</accession>
    <name>A0AAD2G317_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G317"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="280" mass="31936" checksum="DC66F17BD3CE428E" modified="2024-05-29" version="1" fragment="single">MGMSHSILFNASSMTKQLPQLYKSKQLNAELASIQSDKDDLDGYDSDFSEDELEDPEWNERLAILEDASNLAKMADFFLNPHKAVVTTDPYVCGRNYFSRPSALPQQSQEEEAERELIMNEMKQLKQLAMDYLHPERPVVTTDPFACGRNYFTRPSAPLPEDEEIAAERDLVLKEARQLKKLAVDYLHPERPVVTTDPFACGRNYFTRPSAPLPEDEEIAAERDLILKEARQLKKLAVDYLHPERPVVTTDPFACGRNYFTRPSAPLPEDEEIAAERDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3N8</accession>
    <name>A0AAD2G3N8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="3 7">4.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS19036</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>hydroxymethylbilane = uroporphyrinogen III + H2O</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="3 7"/>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1961093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3N8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042:SF1">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042031808" description="Uroporphyrinogen-III synthase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="9">
        <location>
            <begin position="79"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1961093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="298" mass="31718" checksum="6002C364B0801519" modified="2024-05-29" version="1">MGIEHIQGTSKVRLLLSLCLFILAGESSCFSTPSFTTKSSGLTAASEGRTLVAVTREDGKNSKLLKVISDDLELGSTTELLELPCIEHASGADIDILGPTLKSKDWDYVAVTSPEAAKVLASAWDIVRDNPPPVVAVGVATERSLEGFSIDVCFTPSKATAETLVAELELNGPSTSLLYPASARAKKTLQNGLEARGVEVTRLNTYDTVTANWSDDKKKASEEVKIACFASPSSIKGWLQNTNENNNVIAACIGETSATACRNHGWDESKIFYPEKPGIDGWVQAIKDAAASITVAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G450</accession>
    <name>A0AAD2G450_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G450"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10912">
        <property type="entry name" value="PIN_YacP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="YacP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="YACP-LIKE NYN DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547:SF1">
        <property type="entry name" value="YACP-LIKE NYN DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="388" mass="42845" checksum="189EE2F78CDFCC12" modified="2024-05-29" version="1">MGQTIPTIEVANTNLGTVASPTRSFLTMGGHKDGKKKRKGKAASSTSSQSVPAATPTPTPAAPRVSNDINVSIRRQIQYGKLNKKMREGGTAAFRQKKVARTKYRRAWDEEEIEQKAEERRRKGQDPDWDVILNRTSTPPLVIVDGYNIIYKWPRLKKHMSKNDPARARQLLVDDLENMRSIKSWRIEVVFDGAGKDNRNGPLGQSGQRRISATDQKESKDVSKHGVRVVFTGTGVEADSYIEGRCLQAKNVTKGELTGSLIVATDDAMIRSAGTSAGAMCMGADRFVSELKAIKKAVAFRVEVAMAQVNGERMRPEKLWGTTTFAPTNTVNPANLRPLSSSNTTKATESQIEGIKGLQQTEDGRTVYTGRFGRNAVIIEDRRKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G489</accession>
    <name>A0AAD2G489_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional lysine-specific demethylase and histidyl-hydroxylase</fullName>
            <ecNumber evidence="3">1.14.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS17865</name>
        <name evidence="7" type="ORF">CYCCA115_LOCUS20048</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ROX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001997">
        <property type="protein sequence ID" value="CAJ1959442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G489"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.30">
        <property type="entry name" value="50S ribosomal protein L16 arginine hydroxylase, Chain A, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="NO66-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="MINA53 MYC INDUCED NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096:SF8">
        <property type="entry name" value="RIBOSOMAL OXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="JmjC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="204"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1959442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1963197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="563" mass="63191" checksum="C8B3C9A52130E406" modified="2024-05-29" version="1">MSKKHGIHLIYFLFYYLLFLSAFLVVVVVVPVNAWEQTPQLLVLRSTYQRHPTSIATKSYSGSRWNRRWNRCRGVIPSSLRTTPTTLHASSSWTEIPSIVGPFDAKAFAETQCWGQTPLLLQHSFGGTQVFSWKDMLQLAMQDESSSVTSRLITHQPGTLDTFKLDFGPFSELELSNFLIVDSDTEELRDDPDKNEKDVFNQVSTLVVNDVDRWIPSLSDWMDIHFGFLPRWRRDDAQVSLARKGGGIGPHVDNYDVFLIQASGTRTWKVGLETLSVKDEFGNLVEASEVRVLDLEGQPAGEFVTIQLDPGDCLYLPPRVVHWGSATSDDCMTLSVGCRAPSASELLQRITESMSDSSSILATARYTDMEDIANWSKQQHGGNQKGLSKKVKDKMKRLVLDLIEEQLDDDAFWDKLVGEVVTEPNRPTMDYPIPLSEMDEEWKTELGIWADSKQALGGVLGGTGVLRRAEGIAFAWSVLEENEKMGPIMFAQGRSFPLNDNSDAASLLLDMIANGLPLSRQRLDEQGVEVSDTMKSFLLELIEEGLLYGDDDDDNNDDDEYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4H0</accession>
    <name>A0AAD2G4H0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4H0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041970381" description="Methyltransferase domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="193"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="463" mass="52991" checksum="576A078067220560" modified="2024-05-29" version="1">MQLLKPALLATLFAAVSATYDNEMNKNDIDNQNINNREEYRGLRGGLPQQEPELTIYQPLVTSSSVAEAYISTNARIKETLFMGDNEIPGEVLQEPGTQEQPLQKEDSRNSSDVKRDHGQSSTQYGWTDEEFEQHLHGELKKDPIYNEYKAVFDLAPKCISKWRQRYRGNPSIWKRIFQKDRVLKEFIEAAPIIEAVQKLVENSDLEGNQKYTIIDLACGRGYLSMILSEMLPPEKVKKFVLVDKQWPMHGNEPKPSHISWTHIYGSFKKCEDQTIPNYYETWPIPLNTSKQDLKSASGLRKMEQVYFQDGPIILVAVHLCGILSIKAVELFNNNPSVRFFVLKPCCLPGMVHAKRDEIFKLGPTHCFDAKLVCMAGRWKKNVWRGPPRTQLKSYFERWAENLYLGIDGGDARKIQKHVEVQSKGGYQNEFLFAERLPGSEFLWGGLFCRPVDANAQAKTPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G553</accession>
    <name>A0AAD2G553_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G553"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="213" mass="25007" checksum="142CB673E02A2391" modified="2024-05-29" version="1">MEELERPCIKPNDLTPMEVKRRTGFRDLPNLLSYAILVCHGDLDQLFTTCSKLTWLEEWLFYFEFKYGRTACRWKDYEKRCKPLQKPLQKFLLEKLSLELGTRDQWRMYAAFEEDARFCDRKWDNYFDPITGERVVMHDAAGIPLPCPSKTELQRALFSDYYGTTCAKAGVSNQLCGWIRGMPLMTGRITDSQMIKDSEVLVEQRKFSEAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5V9</accession>
    <name>A0AAD2G5V9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5V9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="462" mass="50745" checksum="0A2CEE7BD0EB8035" modified="2024-05-29" version="1">MREIPSLQVLCLRSVGGLGCSAERTFDPNKGKKKKNENKRGNNSNAKQDDNLPQNPTSASKLLQSFDGEIKINRTPAIGKGAVRRKQANDVDLNHPWIGIWSSDDRETQVLQMEYGSPSLDVLQCFIDSLVELGRMDDCKLGVHFFREWKANVLAKKESNTVVVKSKSRKQTPPKKKARREQEVSVKLGSLSLHNSVLGEDTVNAMVESKMASHLAVLDMTGIQPLTDDLLFPILKDASNLKRLSVKNCRRLTSKTLEHLGQYTSQLTSLDIGGAYNLKPQAVLEACANLFYLDELYASGLGWTDGLLQELTSLRGWKGLSMGFAPLLTAGGFKAAMLSQTKSLISLSIPFCEQMVDAALLGALGRHLPLLRALDVRGNTNLVSLTGWYDGRATLAPKPEAQPLLVLARYSGVAKASLEDTKRIHPLDALHLDCILDSDGIGLGIQRTMEVPSENNDEEMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8J1</accession>
    <name>A0AAD2G8J1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS21734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8J1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20404">
        <property type="entry name" value="Tudor_Agenet_AtEML-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041991615" description="ubiquitinyl hydrolase 1" evidence="8">
        <location>
            <begin position="33"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="3"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1966151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="441" mass="49457" checksum="77D7FC6D8DF7C7AD" modified="2024-05-29" version="1">MTRGIKNVSGVSCHISCALQILLHSLIPICDALTKKENGPHPSRPLHQMSEFAKELRDDSPPDDENPLSPVDPSPLYKMLKDFRSSTAKSTLSLEPEDVGDASTAILMLLKLLRQQSKDWASLVDLCSMGSMRYSIKGEYHIAASDGSNKKRIRIKPGKIKQMPFPFPISGEYQSLDEALKTALQPTEVVGYNWQSQKPESYEEICYDEAGQVVELKDDDCNSDNYDSKTEWKTEKALHIEELPHYCFFHLDRFSYDSMGDKTLLNPTVEIPPSLELSALQSKAEGSLQLLGGILHVSEGGKIEEEGHYVTLVRIDEDVWVLIDDETCTEIRSDETAMERLKGTTDDSGNFVCATLVAFGPLDQKANTNHRDRMFHRIVGQIQSQTPEEVVGKRILVKWAKEKFYAGIVKGYHAATGKHSILYDDGDVKQYVLSQKIAEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAK0</accession>
    <name>A0AAD2GAK0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAK0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="15326" checksum="C0D8328FB990F043" modified="2024-05-29" version="1">MVPGLDQNLDYKLEPWMELETQLVLNLEPLRVIYSVQQSGGWTDDALGVSLGMLEEGIVGLELESFVGVDVGVPENIKLGRALLGLSDGMFVAFNDGVIDGRTVLGIIDCSAVGMPVRGGAGPPVGARVGTIEGKDVGCLLGCIVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAT6</accession>
    <name>A0AAD2GAT6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1967976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF1">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="253" mass="27918" checksum="E4811B8A2651ABA3" modified="2024-05-29" version="1">MSPSKFRGIVNDEKKLLTELCEKWEKVLTIESESTADEAATNKEGKEVPTGEDGPPSSRTRSKTQATGTNNNNATDVEGNMDASKPATEQQSLPDQKTKPAVVIPVEDEELIGLVRATTGQGRMLLRQRFVQFESLIDDAENKTSEKPIRDDDLQGFWDMIGFQVDDMKEKFQVLEQAEANDWKLVPPETKKEPPKVASKPKAVKPSSSTGSNTSRIKKAAPTSGMKDFIAQKRREAAAARKKQLQEEAEAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAX1</accession>
    <name>A0AAD2GAX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium/hydrogen exchanger 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Na(+)/H(+) exchanger 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Solute carrier family 9 member 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS23204</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002380">
        <property type="protein sequence ID" value="CAJ1968367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF191">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="15">
        <location>
            <begin position="23"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1968367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="626" mass="70364" checksum="66A96327986A9166" modified="2024-05-29" version="1">MTSGTTRQIEIFFLCFFGLLLILLFLSKFLHNRPKLHSILSEPALTVVFGIICSFVIKALQRIDASSVGDDDESDSAYLAEAILEFPTRVFFMALLPPILFNSGYQLQRELFHRHFGAISLFACVGTCISGFTVGYLLYMAKPYFGSDFDPTLLELMTFGSLLAATDTVSVVSIMNSKKVDPHLYSLVFGESALNDAVAIVLFHTMADFMVQHGENMDHDSFVEYVWAYFLSFLVEALCSPLLGIVFAFGMALTLRYGDLKEHALIELSVFLLPIYISYILAEVLGMSGMITVFFTGMFAKRYMEPNVATKTAQHADVFFQLAAFLAETSIFLELGLSVFGLSGNYYWKFIGISLVVSLVGRALSIYPLAVIHNLSLTRLKRKEDNANNSNNKTESTMDDSVPSQGSHLTNAVSNASFETPVNKRDKLIPLKFMHFLWFAGLRGAVAYACARKFPDIYGHNAEFVAATMVIVVFTIVFMGGATELVMVKLKISVDVDEREYMRHWHSRRKLKGFLHRFEYQFLYKCAVEKEDERELPAEPIQEMATWEVSNTPIQATSFGKTVLANQADSHHFEHRMDNYINGGVVVIDRLNQQRFSTRTLSDDSMSFDYRNASDPSAVQCCAQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC12</accession>
    <name>A0AAD2GC12_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC12"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="CONSERVED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163:SF1">
        <property type="entry name" value="DUF501 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041917457" evidence="1">
        <location>
            <begin position="18"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="229" mass="25502" checksum="16C4D58AF47BD79B" modified="2024-05-29" version="1">MIKAIFIWFSLIFVCAALSATSGSGATELERVRTQLGYVPTNFISVSAWKSDLQQPIAIRTYPLNGGAKRRQSKAGVPGQAVNSPFPTLYWLTCPDISKAIADLEGRGYLKKIEASIRESSELTNKLVQCHIQYAEERWNSLTEKDQQLLSDSNNPSIERMRIMMRDSGVSGTNFTMYTEGVGTEMPSIKCLHAHYAHYVSTKDTLEFPNPVGAMVHEALQKCHPEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCC8</accession>
    <name>A0AAD2GCC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BI1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS23694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCC8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042137864" description="BI1-like protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1969410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35633" checksum="21C7E00BDB4F4613" modified="2024-05-29" version="1">MFRLGLLAILLTIVAGRHQPPDPTFGIRGGSSSLPRSPPSYFSPWSPPKLQPWSGSASTTQSTPTRDAEDVSTKEIIDSFLTRDSRTTFIARVYAILGVQLIVTALSCAIFGTHPFLSSLPARIASGEYQGTFALIPLFGVLISSVSWFRVSLSPNARHRSPNKWWWLGIFTLGESLSVGFLTTFFKFQSVILSMVATAIATISISAFTILQKNPKYDLSQWGNTLSSWALILLMYLVVVWFQQIGIIPIEVLPFSNILYSFVTSCLFSAFLAYHTKLIVGGKHAKYRMNEKDYVLGAMALYDDIVNLFLNILQILGEEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCK3</accession>
    <name>A0AAD2GCK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002450">
        <property type="protein sequence ID" value="CAJ1970036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="99" mass="11347" checksum="F32816FCAE5EE66C" modified="2024-05-29" version="1">MSRLSIKPSLKRIDPEEKKWCPSRREMASLQTYQGISENNPSSRSEMALLNNRHLITTDLSSHRWGKSIKQKRNGVALGVFNCCMLRLSRRMVTVVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD90</accession>
    <name>A0AAD2GD90_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002469">
        <property type="protein sequence ID" value="CAJ1970140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042011729" evidence="2">
        <location>
            <begin position="23"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="384" mass="42834" checksum="3231265FACB3A2CA" modified="2024-05-29" version="1">MLSLRSIIMIFLLLAMQPMAMPSLMSANYTRPSIQVYSLANEDIVSTVDFVGTTVEMESTGVPSFSLAEFIMSIDYESVKAFAQDFSKKYEAFAEAFTDAMSAIFEFFSMEYNAYKQSINYESIKAFAQDFIEKYEAFIQAFTNAMSAIFEHEAFHQPIDYESVMSSTEAYIQEVSTAMFSKIELFIPKFEAYNQEFQVEYQRIYKKLENVATDLLVAEASASAWPSLLDPEFIVRDIFDGVESYTTKDPFAPTPVPPLLSLEDAQAIAAMDVVLDSSTTFGGMVIALLLVATVTTVIFAGSVIDQGLVSMEDLSIVLETPCLSMTDLRKKMTPSVILCSADAYARYQASCDKSKDPSIVDLCNLFANISFRKDTTDPSKKESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDT3</accession>
    <name>A0AAD2GDT3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002415">
        <property type="protein sequence ID" value="CAJ1968969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDT3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="140" mass="15706" checksum="9377BB881AF79AD2" modified="2024-05-29" version="1" fragment="single">EQVQELVALPALRKRWHERQTITPEAELETDWTSLARAMSSLPAGVQRWTTKHAVGMCGVGKFKVRWGAADSAACPCCGEFEDHLHVPRCTAPLLDQWLDTQVTDPAIKHAILYLLQGARDPSLPRSRLVPVRLRRAFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GE76</accession>
    <name>A0AAD2GE76_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS24314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002491">
        <property type="protein sequence ID" value="CAJ1970294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GE76"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="528"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="607"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="4">
        <location>
            <begin position="752"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1970294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="89322" checksum="C669D8065EE0A801" modified="2024-05-29" version="1">MESLPSQQPQQMIEIRHDEPPLNYDLSPSMYDARTLDSSGNLGHVKQSQPFDQPGESITAPLSQDSFEIPIDMQTTILKDLSKIWHDPEKGSICVQLIENARCPHPALLGRLSGPALAILDWNEQKAEEHTGTVLCGDYSNKWLDAGEYFVEIIVLFCEDFGLGAMERTDNETAWLGAGFGTNCVEDAMHNRITAKEGNKIQITSSTEGKGSYHLGRWVRRQGIPLRPLFTRYQPVKCCVQSGGYRPLNPLPQWCEPLTNRDKPGNATRGLWKFKTGTEVVGLPEYQFQWGMNISEISLVNRLRRRLHDKSLPKICAVGDSHSRLMEERSLPQLNLTGMFEFVQHYWIAPNKIAPKIFNRKCDKVFIQIGQWPPSWYTKGNPTSFAKYYKKMKEHVQNTLKVLETKPDAKIYLPTIDQGPLTGRVNACNDWRIPTVLDAYSFVNQMIKRELNTSKVEYIDTNFIIYTHWDGHPDWAHLMEDMLPRLSFLPALLSLCSSSTHAFTPARLGTVTRPICTQLFDATSVSEVASMRAGEIKAELESYGISTASFLEKSELVDALEKARLEGLKPKKKKKRRNDDTGASPSSSSESDDRPREERLTEELENCRQMKASELKKELEERGVSTRSFFEKSEFVQALAAARVDGVEKKNEESYAEYADVEVLTDDNSGPRTKQSPQSQQQQGRSPFGGASPFGGAGMGGMGGMGGIADMLKNMGGGAAGGGAAGANPFGGMGGMGGMGDAMGKAQEMMKNPKVMEIMAKAQSNPKIMKAMQECMSNPAAFAKYQNDPEVGELMRELQKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGC9</accession>
    <name>A0AAD2JGC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001716">
        <property type="protein sequence ID" value="CAJ1946865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGC9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="200" mass="22879" checksum="F1C8EBD6C399F76A" modified="2024-05-29" version="1">MWSGTLKTCPIHPIQAIRIKELKTKDIAILQDLKAIIKDDLRETVLRPKDALGNESIKQVDFQTTDLQEIFKTATLKTIIMLDCITIKTEVKPKAQFLITTIRKRNALFWLELSPKRAKAECLLPQSSMINNSYKANSSNLVNNKKCILLLKTRILQMNCIFQQMIKAIIHMMMPLNITATTMKHIDLHSKTILVHSLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH48</accession>
    <name>A0AAD2JH48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1948957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH48"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="887" mass="100484" checksum="98F6AD20765BDFCD" modified="2024-05-29" version="1">MDEAMLEAVVQFVDKLVELGVLRSIDEGLVTVLTNAPLFVVGKDGQPGQWRVIADMLRGGQNDCVGQDPVFMPRIAHIVDQMYTEGYSAVVDLSKFFYNFPTHPDDRPYLGLLHPKTAELLTYYGLAMGAGNSPAIACQIGLAFVRLVKEKFGVFQGAVHIWVWVDDFLIHGPTHEKTARGLQFFLDTAVDCGFLFHPKKLVPPQQVVKYCGFLFDTTAVPCLPIPEAKKERALAICDYLIQSPKHKKWSRLGLAVAVGVLESLTEATPRQWGHTHLKEFHTFVHPPGLGNGAAPYYTTTFLNSEVLDKFHWWRQFLTRSEGRFVRGWEAATLVPTFGDGSGTDTGGTIQLPNCDFEMWQGKWKPSIYIFPSVWKELATLKETLLRIKESPHAHQVIGTTVFYFTDNSGVYWIATTGSSRTRSLHKLISEIRLLELDLQCVLQVVHVPGRVLITQGTDGLSRGVWMSALQNIMDSDRLTQAIFDPVPFDMTLVWTHLPQSAPLTQYRSWNQPWTASLCLHQTTVWCPPPELARQLLTFLLNSWVECPFTTSALLFVPRVVEASWRHMSPSTRTRPTYASRHSCRYQLLFCTLRLTLSPLIPTLGWTRLPLPPPLGMPPKPHLCAGCQRGFSRKEIETRLQCTFSAKGFGRFRACGSTYHRDCFRAGEPFKTRRLRDEGLTFPRHATWPNFVCEACTVRQYLQRELVCADDLLLLMLERIRMLDIISSWAKGTHASYKSKLSIIRQFETNFAIQVLKPTALLERPSGPDIPLMWCQEWYSLRHSTKAHDRGAQTPISFGTVRALRSAASQWLSLDSLNTPQNAYMSQDNKVLYQDCRPTDSLSFHLFAKGMVARMGDYSRPSVALLDRHIRALDHFLDPQFYEATSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHG0</accession>
    <name>A0AAD2JHG0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001775">
        <property type="protein sequence ID" value="CAJ1951008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="475" mass="51980" checksum="BADF16A30F3FE212" modified="2024-05-29" version="1">MLARQAGQNCVRKSRAFLGRPLWDSRSSPLQGKGKDTIIIDDLSCINSRMYHASAKRDVLPLIAAGSLLLIGRWSWKALNRMDEEWEEYQWQLQQYERERMRDSSKVSDMTTLGVDPGSVYLKLSTIDGGKPELIITSQGDRYRFAGIIKGEQIEDCISGARAMEKFYFEDIEELKGGERVVLPIADGFSSLVKHVVAPAVGEAMERLVKPNMRVVLTLPPAIFNQKEDVLLQSMREYYERSTIVPDPVASIWGARIMGLLPDPATKEERAAPSLVVDIGGLSSSVSLVSGDVVEASCYLKDVGGESYVKTIVDLVKNETGDETLNNDAVCLALMDSSARSAVVELVNKTNTVENHLTKETVPNLIEDGVFSTALPSPKSASLLFASAITKVLEDSEKTPSEVKHVLLVGGGSKHLFFERSFREGVDSIFGPGLQISVVPETALRADITALGASSLLPNFYYSRESGLEAAAKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHS5</accession>
    <name>A0AAD2JHS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHS5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="275" mass="31121" checksum="42C37AFFD48FC39A" modified="2024-05-29" version="1">MGIFKRKSVIIEEASLSWDNESTRKQALVLGVMIAAILILRLASERRLKMLSGEHTLKMAALNDAVLFQEVFLAYLNAALLEPILAIGGMEEVKGGEFAINALSAAAICWWIWLLTDAFDFTDVVQFFTYHGDFREQVETDPKKYFFLKFSKTKEDARSERKSLVGTLTKDVALWFMLVCIAAAWLPGIAVTHRDAIHAYAVVVLWAIMHHVARKATAWSAGYFFTFLFPSTALMPLEYCLPLMDVADVVEDVEWLVSYRKFVHDRTGVDLIIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIA8</accession>
    <name>A0AAD2JIA8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS14215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000013">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="152"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="597"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="712"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1953615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="797" mass="89473" checksum="179D274B44B3EB82" modified="2024-05-29" version="1">MTVDIHLLPNVGRATAGLPPTKKTSSSAGRLPFQARNMNTMRSSANSSSVEVTKPGLSTLESSGNDMNKKLTSSASYLQTRRGSENSEVREGAADPPSTGDQQRVPSSSVPKAGMYKRTSSSSSSEKGGEDGIIIEEKRKKASGDGFTVHRYMRGKLLGKGGFAKVYLCTAMDTNKMYAIKIVPKANLVKARARQKLQAEIKIHRTLKHEHVCEYKHFFEDRQNCYILLELCHNQSMNELIKRRKRLTEPEAAFFMRQLVEAMLYLHHEQLVIHRDLKLGNLFLDRNMNIKVGDLGLATRLENAEDKRKTICGTPNYIAPEVIQGDKATRGHSFEVDIWSMGVILYTVMVGKPPYESKDVKSTYQRILNNEYSFPSKVTMSENAKGLISSMLQSKPADRPSLNEISMHPFFTNSFIPGSLPQSVTHVAPKWDSATMVQNSSNGLKKTIQPLVSSTRGPLGYRDVNVDPVNSDPLKAAKSHMPSIEVVKNVVSAVMGVGSTKNSEKQSAFNVFDETEGNRDEEIVSRTAAMSIRTEPNEVAQRPTPVPSPTSDDAYVLHNMIDRIESVLETTSKRSYADVDVNSISLRAMSTGGPDKWVSRYVDYTSKYGLGFLLSDGSSGVYFNDSTKAISEPEGDCFQYVERSKVSVETSRRGEPVVASHRLAKYPDILQKKVTLLKHFRNYLIEQQKKADEFESNTPSLPVNSDKRDMVYLKKWVRTKHAIFFRLSDNTVQIVFYDHTEILLTPDERHITYADKQRQRKTYYLTDELVGTNSEINKRLKYTKEILLQLVTGRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIS7</accession>
    <name>A0AAD2JIS7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001868">
        <property type="protein sequence ID" value="CAJ1954293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIS7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="14381" checksum="46FDC5C31CC2DEAC" modified="2024-05-29" version="1">MDDFLLELEIMSDLFDFGSDKDEGSSSKSSYEREDMRGRGPRAPKVARNPYIGPFSNVYIKNADEQNANDMGSIQDQKSTLAKGFWRRFGISHSSFDSIAKDWDVDGEYRALKRRNSTRRIDTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ07</accession>
    <name>A0AAD2JJ07_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF30">
        <property type="entry name" value="OS06G0587000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="79002" checksum="FB9D588942A29992" modified="2024-05-29" version="1">MSTYCEFEDICGKRGRPPLNSKDEEVMVQSFFQPFGQSSRDDQSGRFSQRGDLERGPSGGSARSGAHYPDNQELLDYDYPSVPVQKVTIMTEDAADIDPRPMSRKASSRFHPSPPRSRSAPQSDKQPFDVPTNIQITTNPRNHATMYQNNSNNNQVPPQSAQRGPQRYRGGGGGGRQEEESTIFGEDMKSANTMLDEADLRTPPRTRNANMRQQHPQRSPHHREPHIDYSNEDDSAMLGGLQFVSETGTVKPLFPITESSQQSQQSMYSYSVESASHRSSPTPMEDLPLDEYNVTLAMDDYSKSSSPSRGFGGNVRHRLPSQKRASNFAVLERRRSRCLRGFGIVTILLAIGIGVFAYMEIVDGQQNVTRTGSGSGSDPSQAGKSQGGPKPNNPGPSVPSEPSVPNRPPEEVEELKASEAYNILGPQVENPALLLDPETAQGKAFDRIFQETTAAREDSGDGAGRYLEELAELEDLEPMEDGRQLQTEFREYRITQRFALMVLYFSTGGESSWLNNMGWEVFERNECEWHGVECFNRNRIATNVTLSQNGLAGELPSELCLLKEVEYLVLDQNALSGDVPECIAKMKMLKDIDLHQNDFNSVLPNEFFLSDSLQTMDFSLNQFIGVIEVPSVDTGKKGFRSFGGFKTIKLNDNKLSGQIDDAFMFFTGLERLTLHNNNLVGGIDVMCVHPLREFTADCTKVTCTCCSKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ99</accession>
    <name>A0AAD2JJ99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="717"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="809"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1955575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="848" mass="94590" checksum="2C5BA6120D85B4CA" modified="2024-05-29" version="1">MTAEGEDSAAEYKLLQKKIRKVQDILTKIEREQGTKNKLYRAYTRKLGDYTMRINDNEEFNKQFLNTDLDEEEDQSSKVADKPDDISEASSAKTGDLSFDDPDDLMSRGDDDLSDDAESTGDLSLDGDIEIDTSAMEIPKEEESKKGKKKKGKGDGLGYKALQKKLKKAKKSMKILEKEHGKKEAKKLDEYKGHLKNKKKYQGQLEETPEYKKEHGIEDAPKKDLDFPENGVWLRIIQINDVYELDNFPNFKTLCDTKAKETKNGQSPGKFLVILSGDFVAPSLLSGLDKGRGMIDTMNKCGITHVCFGNHECDIPLPALAKRIEESDFAWINTNMREIDDVLKVKTDPHEVIKVKSADGSVEKQVGLLGLLTEDPSVYRPGAFGGATIEPVLAMTKTYMRDVMDPLNLDLVVPLTHQRMDPDREFSKTFKGDVFPIVIGAHDHEPYDETYEGSRIVKTGMDGHNTAIIDITWDAAKGDKPKIDVDMVTTQSYLPDRTILKVVQGHKRILNELQVARLFKLSNWLKGEGKVFSTKDNRLGASTGSEVLCSMFRMGMRSECCICNSGAIRAGKVYPKEHEWFTWSDLKAEVPFPTELTTVYIPGIVLQETIKYSRRLAVQDPPSSSGGYLQHCDQIEMDEITCEIHKIGGKPFEPSHKYLLTLPIDALRGIDNHVPLLEWAEKEHGGGASCANDEGRPAKIVMVEMFSAMMWLDMGSFSEIDTNGDGVLTREEVRERATKVFGKAVADLVVENVFAVADVNNNGYITPVDMMVINFAATDMKKHIGSDNELGAMQEVAADVLGKRASSIEVQDMLKAMMQTLDSDASGNIDRAEMINVVGNLHRQSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJN5</accession>
    <name>A0AAD2JJN5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJN5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041966848" evidence="3">
        <location>
            <begin position="26"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1956795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="674" mass="76111" checksum="C1DF071D1DF02B6B" modified="2024-05-29" version="1">MSPSPVAMKTLVSILVLFSLSVSLSFVVFGRKDEPVSLKVLFGDDDDDYVLFSTLSFNNIQRLLSDESNRGQDEDEEDWWDTIWGDNDDDDDEDGSDKDNEKDKNKNNNTANSPSQNRPSDDNLYDCQSMLNYLDHLPPECIQWDHNIPVIGAPTSDEPDDVRNTTFEMDDILVPMSFRVGVRKRLNNGQVDRLRRAVAISVSRILHRKSPFHVPEPIRIDAFDSFLVDEDADDEQGTTSPSIAVMPDAAPSTQPPSEEPNERLPNGNPFIDLSSINRAAYSDVIPDERNNKARRSAQKKGKIWLHHYSTDLVDTETKNATTGRWYYPMAVNYVVFWDVLSYLIEDPRILANVTRTCWHIGNRTLANGELERILLGEVKNDTLFDFIYPMFADDDDEEDEAWTEEEEDVFELDGQDQGDEIPTPNDLGDEEIISTFPTRLSSSSWERREYFGLYMMLFTLVFAIVMRFCAARNQRHDSKAQLSPISDSHVLTEEGVNEILKAGWKYQEHSTGDDSQLFLHVYDKSSAGYTKDNSMLMGGVEKMEIDANTPYASVPPTLNTAPTDHESNSSANRDSERKTISSRNSEESNRQQPPLTNATSTTSQLGDGKRRENRSRRKSERNSRSSSNAARKSASVQPPSTRQPSTSQPDSTNNSVHTDLDEVVGDLAEQGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJV9</accession>
    <name>A0AAD2JJV9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJV9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="102" mass="10980" checksum="9D49ABF2B69D338F" modified="2024-05-29" version="1">MPNNEVASPCHSSRGRIPEVDNEDSLISLFASSFQSSSSPAAPRTSASFLPVSSPIPPSHSYQSDLDVLTMAGDLTGEDPYEMDDLFQLNHHEALPSHGPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK33</accession>
    <name>A0AAD2JK33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="130" mass="14719" checksum="C1BF75AC76CE03BE" modified="2024-05-29" version="1">MIQEDDRISWVAVPTTTGTSKKDEVSSTKNTPTEDITMIMIAGYIDWKPSCKERDLLYIHPSYFRQGIASRLYQQVLQEALKKPAVSNDATITSTSKLMIQTFSSEGAKPFFEKQNLSTVGAQRFCDWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK84</accession>
    <name>A0AAD2JK84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS17497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042082705" description="Thioredoxin domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1959074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="217" mass="23924" checksum="440410C40F3CD035" modified="2024-05-29" version="1">MKFVVALLTTLFATSNAIELTPDNWDEATAGKTIFVKMFAPWCGHCKKMKPDWDKLMDEFADSKTALVADVDCTAEGKPICDDNGVKGFPTLKYGDPSALEDYKGGRDYSSLKKFAEESLKPMCSPNNIDLCDAEKKAEIEKYQAMSAADLEAAIAEKTKVMDEAEEAFKTGVNELQEKYQKMMEDKEKTIEDIKNSGLGLMKAVKAASAKKGSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMF1</accession>
    <name>A0AAD2JMF1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002097">
        <property type="protein sequence ID" value="CAJ1962187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="171" mass="19002" checksum="D995F507447B4840" modified="2024-05-29" version="1">MDTSFLIAFLKASENIQDGQVMLIGKANADSKADLDNWLIKVIQSDFREASKVLEVQLHSKDGSTLPKHDPNDAGLEKLIVASHTSLAAAAIPAVTLPIDERSIIEILDDSVDDETETDETELNRDIVASMPSAEIQRLRQVKITKVASDEEEVDQEFSQMQQQMMSLYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUY1</accession>
    <name>A0AAD2PUY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS13956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="209"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="255"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1953290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="546" mass="60632" checksum="2135E23C8FE0F1FE" modified="2024-05-29" version="1">MMTKDNASPSLLKTPPRPKRRASSLAYASPSTPFSARRSKSTKPRMSPARSLMRTPSSYKSTPSSYSGDRFIPSRRQMNVDLCRRALLSDEFQDENKDSNKGSSHDDERSPQQPADTPIQKEYKRRMLSSLCNIPLDALNENAEPKGLFSFGFEEKRKLSSSISMRLEDPYSHDTLHVLDKFQGTSDSAVIKGSEGVNRRIPNQPSRILDAPDLVDDYYLNLISWSKDNILAVALAHCVYLWNASTGDIHHLTTIEGNDDYVTSVQWCTMSGQSKYIAIGTNSNTVQLWDCQSMKKVRTLHGHSGRVASIAWNQHWLTSGGRDSLILQHDVRSANHLVAQYKGHEQEVCGLKWNEDGTTLASGGNENFLCIWDAKMSSSQGQRRGRRSQDFAPRLLLQQHKAAVKALDWCPFHRGLLASGGGTADRNIKLWNSNSGAMLNSIDTGSQVCSILWSPHQRELCSSHGFSENQLILWKYGNGSSLTKVKELTGHTSRVLSLACSPDGSTVVSAAGDESLRFWDIFGAPPSRRSSVMPMGDMSFGMPTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW69</accession>
    <name>A0AAD2PW69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW69"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042290004" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46458" checksum="E584475AE67BF52C" modified="2024-05-29" version="1">MILRHGCSLLSITILLSVVAQFEKYIFPSANKSQYKKSVGNGVSSLTEKDMQCSQKELLRKTTFRCPSRGHELREHKNDIPRNISESEYRQNYIDNMIAVYDGIDKDLFQHCTSLSFPLETWDPPECWPVPVILPSYPTSGNGLFRSLLSNLTAPLETSMVMYNSSRQLPTALFRLGPDEGSSTLVHGMLTAGDALPLFRRIVVFKSHMGGKVNNPNMDLNAAKLHVARQHEKLHGILRLARNPGDQMLRNHFRWNSRRCYKEGLECFLEKAHRLCPAMPDVAEEYHNFHTFWSNFDSTMPQHVAYYENFSSKAQVKDSIVAAMQFLNTLTPDVDYERFYKDKDRMAMATGVIREPKYEHGKLLAEVCGVAIARRVHAKTKAVTKELGYVFDNADGTWSLDSTRIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWB1</accession>
    <name>A0AAD2PWB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002027">
        <property type="protein sequence ID" value="CAJ1959898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="951" mass="107109" checksum="3AD57C70941CCD6E" modified="2024-05-29" version="1" fragment="single">RRSAGWISNDAKSCFDRVVHWVAVLAMMRLAITWNALRMMFDTLATSTHRVRTGFGDSEESFHPPSMVPFQGCGQGNGAGPPIWVSVSSVIIRMMTAMGFGFECLTAIDSQLITAQCFCFVDDTDVIEAGKFVEQSGEDICHSVQQAASTWAGGISATGGAINPEKSFWWSIDFVWDSRKGKWRFRRTHQLLPDRPLQIPGLTGELEALRRLEPDEAEKTLGVMLAPLEDQHAHVVHLKSITKTWAEQVRSGHLHKYDVIPLIKTTVMKSLEHPMVLTTLDAATWVSIMSPVLQVCLPKAGICRNFPRDMVLAPLKFQGLGIPHPFGTQVSKHLEVLLRHLSNRTKTGAYMEAAVQEHQLETGTSFGLFQQDYSNMAILASDTWLKRVWKELEDLDIYVALDSPVPPLRCKGDALLIEVFMELEVDQDALKWLNWCRMFLQVCTVSDIVTADGLSIRESMWHGERDYAHRSSYQWPRTVRPNRNHWKVWQEHLTRALLVSDGPQRLLRHPLGPWIDPLDNWNWLWSSTHGLFHRQGHGWQRYRPRSFSTRSIQWDYPRSTQLSGCKRPHHKHTDNGVSFLPAPFWNQPLPADLCRATVHITPSLGSLALTGIGTVPLQPHHDSQPSLLAAWMAASARVTEYVGWTPEEIEIDGDESLLAEALLEDRLCVISDGSYKLGLGTAAVQLLPRMGGTERILVRCQTPGLTDDQSAIACDGFSALLNTFGDNRVTPQQAQFDLVSSIREALARSRASWEPSHVYGHLDTATSFSCLSWWSKRNVEVDAWAVAYRHQLEASHRSIAPNARFFTELAALYIGDVKQSRLNPEQVQELVALPALRKRWHERQTITPEAELETDWTSLARAMSSLPAGVQRWTTKHVVGMCGVGKFKVRWGSADSAACPCCGEFEDHLHVPRCXXXXYCPTDNMIADFMTKPLQGEKFRKFRDLILGPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWC4</accession>
    <name>A0AAD2PWC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS18242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GnRH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002012">
        <property type="entry name" value="GnRH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00473">
        <property type="entry name" value="GNRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1959823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="728" mass="81456" checksum="912BB0959AD5BA99" modified="2024-05-29" version="1">MAKETAADDEVAKFLEELYKEGDIEMDEATIQMIRERNEESQRPSDLQSQSQQHAMITTAENNIEEPIESYPDIDSTSGSDDDSRNHMSNSFSRDWRSHDDSQSPWPMPEDLRIYHPSEQRSRPSSSSKDSGQHYSEGLSPGETSEQVQAEVPSPEPKPEESDDSSDLSSQSTGVKCSTIGLVAFAWLIVGVGLGVGFGIAAANKDDEPAASTADSTGGDKQDHDAVGAIKLLDSKDYFLFGGEELAATMEAIDVSACLEFCKEYDAMQYLQVQDMCACYNSVSCLMPWGPKVDTTNYQFVGDLYTKNELEECSEDYCQALQDKDGLCFTANYQDYTEYSLHGVNIVERESQRVETLEECLDLCSPYDTASFLNWKDCTCYDQAECWLEWGDSFDTPLLLGMVYSKKPLDVCLETYCEIYQDARCFKGNVQDSKEYSVVGTALTELNSTLVSSEEECLELCAPYDAASFRRPDVCTCYENPTCWLEWGENVDTSLFFGNVYSKTPLDFCEFDYCDVNNPDSLCFTGNEEDYRFYSLYGESMVEMASGQTPGSLQACLDLCAPYDAAAFENFADCSCYNSVQCLLRWGNEIDSDDFFGTVYTKRGLQECELDYCDAVGNDGLCFTGSTKSYSTYSLFGNNMEEMAASNDVKNKEECLDFCKEYDSAQYLNFQDPKCKCYNGAECWLAWPPDVTTSGVEYTGDVYSKEELQFCSFSYCSGNLCASGNNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CB82</accession>
    <name>A0AAD2CB82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1919912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CB82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="96"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1919912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="277" mass="31913" checksum="69F37A4F2C52E324" modified="2024-05-29" version="1">MKLLSRARSQKIAFLSASKERSSDTEPEEASSSSSSYGEERELCHAQVREFCRKEGITLSRQQMIRFEHFHSFNAIATREAIKNKHDDAYLKLRMEGDLVSQFKKKMLFPLELRTKKEKAQVLYIRPSRYIPSPTGSDAFIENFCYVMNDMSQTEEQCQKGLAIIVNLIGYSSKNIHRENSKRVLQLLQGEMVPTKVALVLFVDAPKVFRQFWQMLKPLVSDALSKKVHFITSDTIGKYFDEGYQAHLPRDMASGWASSSELVEDYIDLKLFEDNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBW3</accession>
    <name>A0AAD2CBW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1915122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBW3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="52"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1915122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="225" mass="25165" checksum="ECEBD97681B72504" modified="2024-05-29" version="1">MNLRRCQTLTDAIPRLEKIFAEKANPKTANAFPLFNKSTHQAVWKSVPINKERQAAVLVPLVSFQGEPSILFTTRSMNLPHPGEVSFPGGHLEEGVDNSLTDTALREAQEELLGDYPWDEVHILGQSTALPSAGGTPVTPIIGVLPYEIHANTFPGNPQEVDEVFVLSLKELLEIESRERLQRFKSNVPVFHRQHGERIWGLTAVITRPILHNLFKPVLLESSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE33</accession>
    <name>A0AAD2CE33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1902521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11559">
        <property type="entry name" value="W2_eIF4G1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="2">
        <location>
            <begin position="632"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1902521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="811" mass="87911" checksum="CBEE818226C1F3A3" modified="2024-05-29" version="1">MGKNQNKGVKMSLGDFMGGEPTNDLSALPTAPKVRAPDDDGSFQRRARRDDNDDREMSRADNDNSWRRGGGGGGGFGGDRGGGGGGFGGGGGYRDRDDNRGGYRGGGGGYGDDRGGGGYDRRGGGGDDGGNWRGGGGGGFGDRGGRDDDRRGGGGGFGDRRGGGGFDDRRGGGGFDDRRGGGGFDDRRGGGGGFGDRGGAAPAERPRLQLKGRTAPAPKPAAPKSKPAAEPKPKSNPFGNAAPVEKKPVEKKPAEPSKEERKEPELVEEKGENSEQDAEKEKEKKRREPEVVNSRAAALEGAPDVKRDSNNRSQRHDNNNSRGPPQVVNKRFADLADEEREKNKERDDRRRGPPPVANSRFAAAAEADRSYNRDRDDRGPPPVANSRFAAAAEADRSYDRDRDDRGPPPVANSRFAAAAEADRSYGRDRDDRGPPPVANSRFAAAAESDRSYNRDRDDRGPPPVANSRFAAAAEADRSYDRDDDRRGGDRGGGGFGRFDNRGPPPTQNSRFAQAAASDSDYVERGARDRDSRDRYDNGSGPFGGRDDHGRGGGGYDRRGGRDEYDNGGGYAPRGGDRYDNNRYESQGSRGPAKSRVADLLKPKAPPVEENILKVPTKAQEDSILKPPTKKAEEEKPQPAKAAPAPVDVAKVIDDSSVINEFISGNKMGEDLKSWVSDKVITSIEKLVFTLLQETEKLNPDIECKWAEPTKYGAALLSLVEDDLLKQVEVLVGIQKYCDKLGFPKLDGESVVQAMFRSMYKFDLADEDAFAMWKEDETPQYEQGKMNAVIQTVEWFNWLEQDDEEEEEYEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFW2</accession>
    <name>A0AAD2CFW2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042012173" description="NAD(P)-binding domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31462" checksum="776000F23DE287CB" modified="2024-05-29" version="1">MKLTIFFFFFFSFTLLGITAGLNAVCYGPQSRVLLLLTAKLAAREMNDVAVICESGAESMCRRFMYGPEYEEKGIDEENKAKPTSDPTLMETALKKANVILLTGHDNPIEEKAVNTLLNTAGEGLSKVVLVSQMGGSKAKGGFFGGGNSIKESEDYIRKVCQSKGLDLSIVRAGMLKGGGCGDVGDDFGLNKVYYNTLVDVIEASVTMAHDKYSLGADCTLGDTVEMPNMFTQMGSKSSFEPCQYDSNRIVVAGGAVAAALKDGEIEFSIGTQSSKTPPSQEDWVKMFDTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFX2</accession>
    <name>A0AAD2CFX2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000290">
        <property type="protein sequence ID" value="CAJ1933628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFX2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="589" mass="67384" checksum="11B27034488D7E71" modified="2024-05-29" version="1">MQSEEVVDLLLNFTAMEFVASLDDAAFVLAWRGFFGRAMKDTASVVAEVKYTPKDKHKWLRKWPLFVVLLVLMGCYALIRIMQDNRIFGDNEVYIQLHDDAIPWLSTLSGMYFGCYLSDYSDVRDRTDSSVGRIIYTKLPTDRCEDNWKNEHAAFFYCGESWVLAVGDDMMYPCDRWTLRSFKANSANIDAYDILTHSTDLWFAKDEKNISKDGVLETMEFLASFVPVEHVELNCKDLGSEGFVFTFPIYERLDIFIGDRPVYYADAELLENEVNGEYIIFSGRRWLAIRERELHLDCISGCSRTSIDAQCRTECLRSFDLYASNYTVHLISDPLDLRTTTDTWVPTDDLRWYVAEGHGRASKPHIVKQNLFAQIDGIPAVLEAGSAKNATYQQLTEMEELFVPSANLHCECDDKHEEDCYGILYCPDGGTKVWIDLKTDSHAHEIHFLVTELDFFHDTLVQASQVHPYFEWGDLKKEANGYEVLNDTGHFDWHHVQSGSFDHLEEYRYVSCLPVNECGVIYFEDTFGDGIANPGSFEVYANGKALHGEGETELVSKKNCAYHFGETCETEVICSDRPLDIADFFSSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHA7</accession>
    <name>A0AAD2CHA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3954</name>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5021</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000347">
        <property type="protein sequence ID" value="CAJ1934613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000544">
        <property type="protein sequence ID" value="CAJ1936063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042440651" description="SET domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="73"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1934613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1936063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="476" mass="55405" checksum="6EB4E1126208004D" modified="2024-05-29" version="1">MRKSPRVIASFILGCLCVSISTSSSSSSAAAAAAEEEDKAYAYPMNDPQDAASYHILQMVKWLDGMEEGYFNPKIQIRRANPDDPTSYFGVFAAEDLEQDELLLYIPPEARIHTDVKDGEYTEVLCELAWTLHWEFDRGYNGDYIHYVNYLKQLRRDIIPAVWSREAKDLLMKVQDELYMKDYEPKTAHATHLINWIEEWFQKPCLINPKGKYSLHPYFLAVVTQRGFDNMLVPIYDFFNHHNNNVNIYNRKSIYHRTGFDVYASRFVEKGEELFFSYHNCPDCKECVDCDSSQTYWGTPEMLRDFGFVEPYPHTFYLGDYMTFVVSNATLGTKEPTLQDLSIEYMDETYPSAGIVAEAKREWVRIENVYQNDILAADTTKIAPHELYTITQYYKALVNAFKLMVITFDPELAAKMEAEEAEEEEEMEGGEHVEDHEEWEDEEVEECVEENEESSEDLFLAEMDHQEESEDEEDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI51</accession>
    <name>A0AAD2CI51_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI51"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="216" mass="23804" checksum="29ED5A3A58A71A70" modified="2024-05-29" version="1">MASALEQFMKGMISNKSKECGFRIDCVLIVDNAVPDSESHYECESVRSQRSVASAAISVATAETADMTVATSAAPAHKDLDLSDEHIRMLRWSASMGVHTALTELKAVEGRIAERDAADYEKKLRWSAAMGDTTSMAKLNAGNKSSRWSAGCAADERKPVPSKRSLLMQPKRRPSFRLSSRKLAVEEEEPKVVSSRSSLKQPKRRPSFRLPKISFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CII8</accession>
    <name>A0AAD2CII8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CII8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="299" mass="33932" checksum="ECFBBFB7C6828AC0" modified="2024-05-29" version="1">MGKMKNLQMLENCFANSENVRDAAKMEAMSSKLIRQNSRLQKEKEQLARQARKQELCIGHLLKKLENAADLANDQQVNFDEAHHRQTETVASMLQELSKSRKEIIQLRNELELERIKNRATTSTKEQMTEIHRIPSDCEDFSDEATVLRNNVAVPQKDVAALEDEVAYLRHSLIQQESQYKESLKDNAVGSAGLRRFTSTCGEEDAAEARMHHDRFRPDDDIEIIHQPFAHDTREKRIPRSGLQEIDAEAPRPPLSRQSSGVRGSSQSPPKLSATSSNSRSFAMDAVRLSRSSRTLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIN0</accession>
    <name>A0AAD2CIN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartyl/asparaginy/proline hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS3657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051821">
        <property type="entry name" value="Asp/Asn_beta-hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332:SF5">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042068419" description="Aspartyl/asparaginy/proline hydroxylase domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="6">
        <location>
            <begin position="196"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1934240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="382" mass="42779" checksum="6235C40369BCE328" modified="2024-05-29" version="1">MTTRIVLLCASLALTAHQSTSFVPFSTTVRLSSTAVNAGFGKTTSGSGKKAQKKKSKSKRLSNVLQDAPKENASSNKPFVKSEQDDLIASLAAKASTTSIGRAVTSAPVPPDGIDPFWELMPSLVSSRFPNVADKQLERVAGMVRHTLDPSLPLEDSIVNDPYRPHDEIHAYMPGLGETQPFLDPSQLALCQKLSENYDIICEEYENLLRDEKDRFQSVTSMNYESGWKTMVLFYNGHRIPDFPYDLCPTTTKILETVPVAGRIAGFNRQQPNSGIPLHSDGNNMWLTCQMGIRVPDGEKAWIRVGPETKHWKDGECLLYDTTYEHETMNEHETMERVVLHVDFFNTLKLTPIEIEVMQYIYSLREEFFKAEGVAKVGNQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJC3</accession>
    <name>A0AAD2CJC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS4880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040000502">
        <property type="protein sequence ID" value="CAJ1935727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000007">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="188"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1935727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="533" mass="58747" checksum="B8B90B6F2CC8925F" modified="2024-05-29" version="1">MLSRASMSIARAMRKRVHPPAFRALSTVETFGKEQNFTWSSAAMAGAASLFLATGALSAVPVSTECEQEESSLPVFGSSSDPLAGSESKEGLDEIEKLYIERVPYKRDREEISDTSSAFSRGVRAFENSFESAYAAKEESEDPFGGTSVPTPGIISTSSPAVQETVTTNKMYFYRTPQIKSRIARKFMLFTAPSSEELGGDVAHLLGMDLNKVEVGKFTDGETRVEAGESVRGKYVFIVCTTSSNDALMELLLMISAFRKAQAKHITAVIPYYGYSRQDRKVKREPIAAADIAILLQNMGVDRLMCMDLHNDSLCGFFSPSTPVDHLLPIPVAAAYFHEELASVPTPEDWKPESEDDEYYPNITVVASHEGQVGRAAHFRDVLQRLSGKKIELAFISKNRQKRGEKYYTPHVVGKIEGQRCIMVDDIVNTGKTLISNVDELHKAGAATIHAWASHGVFGPRSLSDAPQRIAEIEHLDYLLISNSVANDSILPPKIRQLNVAPFLAEAIARALHNQSINEILNLDEESDRRYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJD6</accession>
    <name>A0AAD2CJD6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000502">
        <property type="protein sequence ID" value="CAJ1935729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJD6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="752"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1935729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="834" mass="91150" checksum="99563C6B347DC62F" modified="2024-05-29" version="1">MKVNADGESMDEFFVNSIQHSATRSNQAIGKATVSLRNRRNLATSSPSAESTIPSDAPSSMPSIVPSENPSSLPSRDPSVMPSAMPSVEPSLRPSVRPSLQPSMNPSNIPSLVPSEAPSTSPSYEPRTVVRPYNLAHDKWALAAVIGGTLAVVVSIACYLYWFRCRRQVGIVRHRPDALTTKDAQKRQDRSSIVPPRSVDSNRQSLADTSSGDPILLRLPTRSGEKRQHGRPVGQIDSIDENSLYTSTYSTRKEPSVSLHSRQSHISQPGSDSLTLEVAALFPSSNHSRSESRHSSVTSASRSSKPHLKELRGIGPLSLDSPQKYSSIAQAKRLPTAQHRNQRKGRVAFGQDTAFTAEGSMSSRRSYASRSQRSYSSHSATARSHKRPERLLDSVHRRQDSLGNYSKSSHNSSSRFGRENSSIHKSVDGTESSLVVSHISDKDFLADMQSLDSNESPSSASGRSFSSRSSRRKGGPLADFLESMMKSSSHYRRTIPQVTPEEGEFLPDNDGASSKKIIRCTSLPPSKRSTSRTGRGGNEDAFSESSSDMTENERYHDQRSPRKVFTHENIQEKGPVVRKVTPPSSASSDSSYRDLGLLQVADFDYSNNGQKWEKAESVVDFSGDNASQSSHSSEKSPGNDWLFDAVEQALGPRSMSADMESLGGKSSSARSRSRERSRCRSSSLDARSRTPRALEQEKERLEIQLASLEGEQMSVTSFVASSAAMSFSTMGSRSLQPKVSSKKRIVVVVPPGRLGVVLANRNSGKGTIVAEVRKSSVLYGMISQGDRMVAIDGEDVTAMTMGEITAIMMEKSDHDRRLTLLTSVDKTSKQYRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJF1</accession>
    <name>A0AAD2CJF1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000297">
        <property type="protein sequence ID" value="CAJ1933728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="216" mass="23212" checksum="289BD2348DDCCD54" modified="2024-05-29" version="1">MSPKCPDRLLPKIQWKNQDQYVDYGKKLNLNQIGATVPATVPAIVPGASASTSGASSVAGSINTPLRLAGTTGNQMMQVPSGMQLMQIPTQGGSTVTVPYSMNANGEIAFRGMQLSQQGFSGAQVRQGFNATQAQTPQVVKTGNCNTSNVFHDAIKGKDENGNDVYLIPCPAGTTNVELQADWHYASENEDLPDLATEADRGLQLLHNYPTKWFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJJ7</accession>
    <name>A0AAD2CJJ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS5221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1936497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="422" mass="47136" checksum="E555A7446AA90186" modified="2024-05-29" version="1">MGKKLQGAKLRAKKRSKLAAQNSLETKAEEAETQQVTTKANEELFVVDTTAVLPSKKQLVKKEQKKRKFSNSAKEEAQINKLVDTHSPTKLQELAKVETAKRARIKKDVDPSFDLWGDDGDDKTPKSKKGRTQSKKKQIATSNPGIGPSLAGTKPAHKPSNYSITAMPDPNTKKVSVDVAEAGQSYNPDRIQHRNVIAKAVEVEEKRQRAEELNAAPISKGMSEETKAYLLEDSDLDDDSSDESDSGEPKEKGPIEKKKDKLTRAQRNRQKRIKQELYDIAQRKKDKKFQNSVAEAKVIAKQLRKEEAEKRQKAQALNKLKEESERTKGKNVYHQLADENPVDAPTYPVALSSELKNHGGSLRTIKPKGSLVNDRMASFMDRGMAAKKQLKQKRIVSGKRRKFKVKVRGKGFEASKEGGIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJS8</accession>
    <name>A0AAD2CJS8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS5129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042269243" description="Cytochrome P450" evidence="9">
        <location>
            <begin position="26"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1936313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="63469" checksum="052F98DCF84E519C" modified="2024-05-29" version="1">MRRRISFHLFSLHFILLFISIHIEGWQPPLRQWWKQRQETSLVSKDTDTSSIPTRLPKAPKLDKLEYHPLIGILKHFQKDTAEALLELANYCRENDLPGVRLSAGIAGTFELITDPKLVEFVLSDKGQPNYKEGIFYKSALDRRGVGLLAGQGSLLSDGPDHTRKRRLILPGMDRSSLEGFLEIMETVSMEYSQSLTSNSTSTSTTQNVGELLSAIAMKIVGLALFSTNVVEKSIYNDIVVCLEHVVWYTRHPLAAPMWIPTRRNRKFRKALKRLDDLVYSLIENGQRQMQGSKEGGLGSKNDLLSMLLQARYDDGGGSKLDDKELRDEIMTLFLAGHETTAITLCWSLWYLGDPKHEHWQDIIVEEYDRIQNETGYTPGVVEDPEALKNTRSVLCEALRLRTPSYAFDREVQQKIIAPGNILWKRKALLMLSPLAMHLDPRYFDNPEEFDPSRFLEYKEGKDLWDGPYDRSVYLPFGAGRKRCIGYKFAQWESLVILGTLLKHVKVKRPEGATSVEWEPGVTLRPDRDLELVFEPREKRVDTGSISGKEESSIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKA0</accession>
    <name>A0AAD2CKA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000569">
        <property type="protein sequence ID" value="CAJ1936857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="444" mass="48572" checksum="0553B3BA7E1994D5" modified="2024-05-29" version="1">MVYHKSRTPTGIALRLVIICLLSMAGHSLAFSARPQPVAVFRHYLPTFSSSSSVSSMPCIRASPQATSRLSPLSSLSPITTKRHYSTSLQASPISSSISDDDDEEGEPNILEKFASLFSTKAATKVSQKYQKIAPITQKTGLLTLFRVGIPSILSGILAFYAFPALSLWLCSFWNDAGVFAVLSQDSSQFVQNFLTVAGLLFSILVGQTYYFMYQQQEMVYYALFSEVTEAKSLLEQVALVCQGRTMYPKVLSAISKYVKTDLKKLSADPAVLLSARPVDDPLETIMYLTSVGVPGTVYDTVRSLRQARAQRLGALQRKLPTVHMLLLWILAAIELVSFPLLGAGTQSIGGYNILTIEGCLFGVMTASIVLTLRVVAELWRPAGGAYNVDKVLKTMVSGLEEELKARMSGKKLDNMKESYPSPAKTIDGDYLGRASDRISKQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKA1</accession>
    <name>A0AAD2CKA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2834 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000624">
        <property type="protein sequence ID" value="CAJ1937259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKA1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15884" checksum="49B590627BB71EC6" modified="2024-05-29" version="1">MSISILQAGPAIMYGGLALGLGYGTFVREKEPSWKMPAIISAGFFCFTAFTVYQEGLLGVIPNHTSNYWGNQVWYDLLYSVGLFWFALVQRAKKVGMPLLPWFIYVICTASIGGLHMYARILHLEEEKGKRDDGPVNANSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM61</accession>
    <name>A0AAD2CM61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000595">
        <property type="protein sequence ID" value="CAJ1937063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="30239" checksum="D5BFE24640ABB216" modified="2024-05-29" version="1">MRSLPAGVQRWTTKHVMGMCGVGKFKVRWGSETSAACPCCGEFEDHLHVPRCRAPSASAAWDRLTLALAQWLDTQVTDPAIKHSILLLLQGVRDPSLPSLRVVPDRLHRAFRSQQRIGYQGLVEGRLSRLWAPVQEEYLQSKGSQRSPSLWVSRLSHQLLLLGFQIWEHRNSVQHSEDNVQLHERSPQVNNGIHSQFDIGSTDLPKVVQRLLSVKRRTVLNKPLVDREEWLKLVKMERTAYRRALAPQRRILYRFFHPQAPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMF7</accession>
    <name>A0AAD2CMF7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMF7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="686" mass="74201" checksum="D0A9B1DC9D43E022" modified="2024-05-29" version="1">MGRKRYTPIAFMSKPKPMMSEEQLMEEIMLGTRELQVPVKPLSANTASVANSALKTSPTPQPKSLRSTASTTAESESRSDDPSDGSNKQQKQQVANKIPPAPALISSTIQRDKVSPMSTPNASPTTISPKPRTRRARPGKSPGRTSKSNVVQPPVTDNGDSEQISAVATSGSAHTSSPMPHSRRSQYSRSPVSARRRASSGNRRSLSTRNLQPNDMMSPLPPPPPLPTKGSEDDDQLGLLSPKTARRGGTRLVEIANKRLQGGGRTSTTSRRSTKLPTIPMIADATANDQQHENGAQEDSLRSRASDDAESLAKETSNATRSRSGSISSAPRSPAVVRRKMSTRSSTSARPQPTNDTELVEDQVSTSRRSSIGNGSASRSPAVVRRKLNNRSIKEDSFRSQSSNDTESKEASTSRRSSMGNSSSSRSPAVVPRRKLSNRSIKNDPLQSQPSNDTESLTKEASISQRSSFSNRSASRSPAVVRRKLSNPSIKDDSLQSRGSTNDTESKEASTSSRRRSSSISSAPRSPAAVRRKQSRRSINTLSATTAPLNDNGTDQSQADSENQGDSFRSRSSNEIESLAKQSSLSTSARSRSSSISSAPRSPGAVRRRLSRSKDPKRRSNKVSDELRESRRMLMQRSQSSNSIGKKKNAGYIKSFLGTSERSLNINQQQIDDSGEKNVVDDEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNJ4</accession>
    <name>A0AAD2CNJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000731">
        <property type="protein sequence ID" value="CAJ1938528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="215" mass="24898" checksum="84D5960EA54EE36B" modified="2024-05-29" version="1">MKATVLLHTHAMVCVQYDSIYTTIFNIYYFKQNESVNDYRRRFEAQADQLFEILGTDVLHVDATKTMGYLDLYDPEDDPDNTKALQDAFKKEVLETFKANASFYNCGRSRFQSMLDKANQTYTMEFKEYDQRNEYPTMIDQAAKALTKHKPDNRKKGPTTRTNTVSSSAPDGMSNAQATARTTSSRPVFSCWCCVLDILGFFKYIFGETRKREYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNK4</accession>
    <name>A0AAD2CNK4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000976">
        <property type="protein sequence ID" value="CAJ1940900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="20900" checksum="2A45D2B8902A97F2" modified="2024-05-29" version="1">MDSGCTNTTICNGGFMHGLRHAEKELDMHTNMGSRVLDEEGFLGRFLPPVYHNEHGIANVLAMHEMIAAGYRITMDTDADNAFIVHCDGNRKTRFVNRKGVYVLEQLGANVKPGAKDTSAMYRRQLSNLNNQPHLELSSNKQNGYAGLEMTSKMATVRKNKEGFTPSQVKAAMEARSAMHILNAPSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPP1</accession>
    <name>A0AAD2CPP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS5059</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="47"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="378"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="414"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1936173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62278" checksum="C266746B90C8A919" modified="2024-05-29" version="1">MGACLGKSEEADNGPSGFEVGGDSKKNAQSVHSVILRHRNIDVYKKYETKEVLGQGSMGSVSRVQVREGQEGGSAFNPKVKKGMTRQSSNVSLSERRAHKVDYALKQIQLDKVSSAFLEELHNEIDILKAMDHPNIVKAHEVYNHKKQIYIILELCDGGDLYTRLPYSEMEAGYISGKLLSAIKYMHDHGIVHRDLKFENIIFESPHPKAEIKVIDFGLSKKFGNQATGVMHEGVGTLYSMSPQVLQGVYTSQADLWSAGVIIYMLLSSHRPFYSKKRKVMIDKIMRCDYNFNKSYWDPISNEAKDMIDNLLVIDPKKRMDATKALKHVWLSKEFKLSDRKPDQTTADAVQGNLMNYKDVHALKKIALNVIAHKSSTDDILELRKCFDQYDVANNGTISYDEFMTALKEKNYPEERVKEIFNSMDVNKNGVIMYTEFIAATLEAQGHIEEERIAEAFDRLDSDDSGFISRQNLTEFLGHEATSQDIQDLINEIDKDGDGEISYAEFLSMFRQNRTNLFDIIEPAESVYSEDGLLGLDAKIPGGKFDSSRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPQ2</accession>
    <name>A0AAD2CPQ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPQ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="528" mass="60041" checksum="E1CE5329FF3D8DC5" modified="2024-05-29" version="1">MEAYIASLLRENAATNLVIVRDDALISSERRQCMDEEPSSSDDEHYWHRPSSFKNTPDVNPAPTIPARKESNDSLHILSASNEIPQHHGFLDKFRGLRNRALGHKRKNKVSTYDEGKESEDVFPMSTENPHINMENTQRNGWDGARSPMESIDELWQDSSPPTLPLRKKSEDSLIEQQSEFTSRYQPRRSYQRRGSLDSALVVSPDCQPKSHSKRRGSLEHAVDSTELLSPECKTRKHFQRRSSLDNSLLLTIDKSKKRVHRRGSLDNAIILPDEQTKHHFEWQGTLNNALLSSDEQTRQHFGRRSSLDNASMLVDQKTRLHHQRRESLDCALLSSDIDSSKQGGFQRRGSMDNTMMPISQPNRRFQRRSSLDNAMTSSNHQAQLRFQRRSSIDNAMVQQLIDHETVQGFTPAEQYRPHENCDSSEEDVAMVASVITDVPLAPEPDRGLKQRIMSKLNSPRWRGKIAMSSDRFRASSIHDEYGCKAAATSKQVADESRSRMQTTAAPCPQRISDSQLSLVSQESGGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ76</accession>
    <name>A0AAD2CQ76_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ76"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="696" mass="74168" checksum="9EA7A5B437034B34" modified="2024-05-29" version="1">MKFFKKKKGDKLDDETATKEEPEPETNAEPELKEEPKEESKEETTDEPKVDSKEEKSPPSSPSKKDKRSSTSKKEEDKKKLKKAASKKTVGDDDKKKKKKKSSGVKGVLGAAVAGTTGAVAAAAGGAAAVANKSKDAVTKSANVVASGTKDLANSAAEQVGMKDKKKKHKKSSKDKKDGDKDKDKKSSKDKKKSSDKDKKQSKEEKAATEEEVPKEEKADEEAVKEEAKEEAPEEAKEEAKEEAPEEEEAPKEDAAATTEEAPKEEEVSKEEEVKEKSAPAEEAAPAEEAAPAEETAPAEEAAPAEEAAPAEETAPTEEATPTEEKPSKEAAATPEAPAAEEEPKEEPKEGEATPAEETEAPAEETPAAQEAAPEPASEETPAAEETPAEDTAEETPAPTPEEPGAEEAEKVEAPEEAKQEEPAPPAEAETPAEPAAEPEGEKEEPAAESAAPEPEGESAVTEEPAAAEEAEKKDEPQSREAPESGSSREKTSSAPSTDFPPLEPINVLDAEDIASMDEAKLKEELTKANAERADFHEKLIKREHELRESAEKIKGLESEIEKQLEDWDTLEEKLGKADAEMKKLLDDAQKHEALKSELGNLESLKAELEKTKAELDSVKAGGAPAGDGADVAAKDAEIAALKKELNALKDDAAGDSKPKGESGDFASLTNSLQNFSNEISDAKKELEAAQSKMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS37</accession>
    <name>A0AAD2CS37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001234">
        <property type="protein sequence ID" value="CAJ1944692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="212" mass="23742" checksum="B6EACF359CE11155" modified="2024-05-29" version="1" fragment="single">MDTDFDNAFVVHCDGDRQMRFVNRKGVYVLEQLGANVEPGAKETSAMYRQLSNVNKQPQFELSSKQNGYAGLGMTAKMATVRKNKEGFTPRQVKAAMEGRSAMHILNAPSTKSLKYAIRSGLIKNCPITEEAINHAEAIFGPDASTLKGKSTRPTPKKTYVDFFSPPEELYQHDRSITVCIDHMEIKNAKFLTCIDTTVRYRSCIPVQNLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS95</accession>
    <name>A0AAD2CS95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1941992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS95"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27282" checksum="0E45E4279F3FE748" modified="2024-05-29" version="1">MLELLLSLDHETSKLFDWLEPREILNLTCVNHALHQACEHWCQAKGVPRQVAMKEAEIAGICDCLVEMEQVAHDDLASPLFQSYQGFLHALLRTPLDDTVINLFSWSIRYWKASQPRPPAVSQRFDFGYPDTGYWCDTFGCGAPNDYFRLVGDAPNEYWSLCLAGSDIQYLSWRSVSNDDNRVLDPVPSPDSRNVTRKKAAYIQSSNGPTEWDRTKQYWRDCGARIRPSSTRWRLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSM4</accession>
    <name>A0AAD2CSM4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS9277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="69"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1945133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="450" mass="49562" checksum="2D26875058B9690A" modified="2024-05-29" version="1">MHENENARKSSSHFTPRNSKPKWDDRGLGNTCRFENGKMFFGGDPFDQFQNGGMDGGPGGSSSNADTTKLYETLGVNKSADAKEIKKAYRKLAVVHHPDKGGDEHKFKEINAAYEILSDPEQRAKYDRYGLEGLEGGAGGSGGHEDLFSMFFGGGRGGRRSSGPKRGEDVNHPLQVSLEDLYNGKMVKMAVSRQVLDGEPKMCTNCSGSGAVVELRQIAIGMVQQVRRKCPACTGEGYMAPKKRQREVLEVLIEKGMKNEAKIVFRNKADEKPNMEAGHVNFVIQQKPHPLFKRKGADLLITKTISLNEALCGFEWRITHLDNREIIIKSRSGEIIKAEKDNKTPFVKIVQGEGMPSHGNPFVKGDLYVLFTVEFPEDGDLKPDQIDMLRKILPGASMAIEYDPEVAEVAHLELGDVKNFGKGGVANHDRAYDSDEGGEGGSQQVQCQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT92</accession>
    <name>A0AAD2CT92_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS9385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="2771"/>
            <end position="2934"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="2953"/>
            <end position="3249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3366"/>
            <end position="3407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1684"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2621"/>
            <end position="2649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2690"/>
            <end position="2763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2852"/>
            <end position="2879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3615"/>
            <end position="3644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1695"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2621"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2697"/>
            <end position="2712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2748"/>
            <end position="2758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3615"/>
            <end position="3625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1945241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="3644" mass="401638" checksum="A5836B7ADBC055DA" modified="2024-05-29" version="1">MRSWIFGGNKNEGQQDDRSQNNPQGESGRPGGVVGAAADALSAFRRGAPDDAEVERKVSLAARNLCYGVQRIVLAAKGKSGVEWKAELLNLLGGADDTVPKGHCDLDVLLVAPKNDKFILRCLENELPPNMIHCLRLLRVLELQHANQKHKENEARLKAGKKTKSIKPISSRATSKVSQLLCTLCTDPSVGEQLRPHLFGLLALSGASYPASGVHVAKGASQVIIAFAENCLSNSLVWFLHDRKMIIHMTDDIKELCGLTADGDLTTSSTSNALSLYGAEAEKEGLWAISLSTVIHLVVNSCRHNCKELMKDFEAAKGNEVLKGAILQSKSKYGKDLMNLIPLLATCNVSEDQEETLPGQRPNENLAVNTAAFGIMEELMFKSLPFLEKYDKEFEERPNPTKKSIKEMAEYTLNLSAKIRFTEEIDESVMSADADVDETTEAQIEGFDVATDLLLSSLQLYSEHAMNFGILESRCHLLTTYVLAFPTLKDENLKVLILKTVEFVVTGVQGPVAMQPFGVLSEVFVSICKILLKGGLESSSEEHKKQMLDGLFADTDLINESMERLFKFDSRVGPAIMQSGTITKVVDDVTELVLQAMEEKKSEWEESFEDDGQKFITPPSETPLDSVCAAICRVLGLILGQKARQNVTILTSSSTEKTKELKYLLVTAVKEMGDEAAFAATGVFEYILSAREELELLREDMVFCLQLSDYFSDIMARSCGVPEAAKEVTKNKSLKSGDELDIKFTPKQPLNDVLLRRVAGVYTMLKKVLESSSLARDAFRLTGGFESMVRTVLCLGGAAAQNDPADDSIVENLMNLLKIILSAVDAGIGIDSREPPSMQDLDVYSRVSSVTLGTGTLVDPVSSQYSAPKPAAKNLYYLRLKAFYLDFAIAISQTKILETPETAVQVFDIAMSHMDPSFSLIQADATSAALLIRNPDAARLILGLSLFLPKTKDGALLSKKAFDNIIRLCDPSRLGSTLSQLANCGIIWSITNPKEFAPILDETSHHLYPRFMLLLRRVASFSMSYNDFVSMLRGISGPLLIEEGESRIRLPVITSSVRRKQKTVDSSKESYQEKEEDSCRRLDSLCNVAERGDRVPFCAVGGDTVNTISVLLHKTKIEDRLYKAADEGRLNFVEVDAVDATSLLPGGFLTAGVPAPGSSGGERLWAPMSTSGFSYSLWFRLPKQSDENKKGKYYLFDMSNPPVTTGDGSQASQSGTYLSLWFDYHNLRFNMLASTQTGEPMSLPTAPLTPGVWHHLVLTYTPSKRTMMGRKSAITLYVNGRPLETEVKIDSVNLAPNAKVVIGAPNPAIAVSGIVTGKILSWDVGPTLMLSTVLSELDATAMFVHGPDFNGIFWGDRPQRLSLSATGSAAFALLAETGEQGSVASALRRRQIARLEAAGTVSREMGLGGANDDNDSLVSLGLLCVLNADSVVFAYRAVSCNRTSPLMKSDISLKKKYWSDKLINMARINSNNEVVSSDASVYGKAGVVTPRCFADNVQWGGGPKLLMPLVYAANSSRSMALALRLIRASTNRHPPNLESMQGGGGYQTLAVLIQGKRFVDAQVLDQAFSFAVHGFYPEEADEMAKNSNDMSSGFANGPLQNSDFWVFSDLDAMKQLLLNHQVWDLKNAGPELPSRLLTFVNGLVAQKSIHKAFNSRRLHLVGIVRWTLHLMMEAAELYTNGELAKRNQQRKQQDTESAPDTPKASSSRWYCEAPHIDAVSVGGNPDNALLQSCKTLLRRVLTFMLTPGDLEAIAETTMHTVSIGGFTAKSNFNETEAESFEDEKLLPGAVARIYLLRLIEELIVDGVNEIVASGPKEGENKTEVALAPHAGGIVNPNQTYFSKAMLEGEAEDGETHPKHFQAQNFLSAFAGVFTPVWFAALLEGCHEEATASAVLRLMILMMQSSPAFAESFEQQGGFAPLILSVPKFSTCSSVIISLLSQLLHVSILSLPTFPMLDASQLNIVFDEESSLSEKVAQARLKALGNRKRDSSCGIFALVAECIGRNLQLVPFDNELGKKAKQTNMAILELLQHRHNLSPAFQDFCRTSDFVEPLSQTLCLIYDERSQQSMSPSSPEDQGAITRHGLLSSVPKDMTPLERFFGVESNDMMLSGAGIILLLKMVVSSSVMMGPVAPALVNSFFESFPIHASSEQVGGYQMVLMDLVKTTVHEAIDLGEATALAASVGVCSVVLNRLMKGFFTSELALQTLTSTLDILKALTSPGSTVSQNLTNMEVAMISADAAHIARLAAVTTLKRSRSYHDEDPGDPELQAIVIQLIAKSIDTLMIVPKSNPNARRGNSGVHQAPPSTSKLYPLWMSASIARCAAGVDLAYVDLSDSDEPVRSFVVGLMVELLSLLNDPRDEIREAAVAVVVQLLQGNRTIMSGLLIKDIQQGDRIETIDVMNRGGFSALLVAHEVAKSSGGTSSKKHYASFFDWFHRNIGMVELVKNDIEHESHRLLPGLHSRATTMAEAVEIRQQEMVMSMASSEASDRTIRGGLERAELAQHCIDSTIENHVHWKRQGFDDLASGAMQWKFLLRRLKGSRTIWEGGPRFEARTFLARHQHLYAYLVTGDVPAQVGMKKEEDDGNSSELVKRWKLDLSEGNERQRRRLLPNYEFHTLYGVEEDEYDDGGSESGVDDDDSKAASSAASRKVRKSARLSTFFHGKNEKPDAKGESFVMEATADLLKELNIKSAKRQDDDDDEDADDDGEDDGQTEATSMTGTSSEANDGAVGSVGAKPSTSEDANDDDSASHDQHHEAENATSYELITGLLQSGDWPEESYNVKRCTGLEVRKALLLWCRDAIYVIDGFEQTEGEGLEGRITRVEKEEFSYNINLRPKDFKVDDDNTSVDASVMAEGNKGEGKNKSAKKGGQEPSNEVTYQHRSQRIAFKELHSVFRRRYQLQHIALEFYDSYNNGTLIAFTNHTEREEILSKVLATPLPNSIFSSSYGTYINYKKFMNSWKSKIVSQWVNGKMTNFEFLMHLNSFAGRTYNDLTQYPVFPWIIADYDSEEIDLDDPKTFRDLSKPMGDLGEERAEQFRERYEALEANYLNEDEPPPFHYGTHYSTAAYVLYYLMRLEPFSRLALTLQGGRFDVADRLFHNIGSSWKSASRENLQDVRELIPEFFYLPDFLTNTNNFDFGITQKGKTVHNVTLPVWAKGDPQRFIRINRQALESDYVSKHLHLWADLIFGYKQRGAEAVKCLNTFVHVTYEGEVDLDSMTDPVQRESTIAQIQNFGQTPSRLEKRPFQSRFVFNALKEKDGNIDFGSLSYLAPLTPPFMVVGAPHRCQVKRISSDMCKLGLSGQHDKAVGDLFLVKGQLVGVGRMCALNIPMKTYYRFGYPNSGLAIHVASLNNRNRELNKLISIHDGMHRSEISVAKVSLNGQALVTGCIDSTVRLWQYENSRFKLRSVFCGHDGWKITCVDISNDFGFIVTACAAGQVVIWDLRTLTFVRRLPHSFKDEQDSGHVRAATSVSINHNTGNIVTLVGPHLSVFDVNGNLLGTENSLGAMPTCAVATNCPEWQEKGIVAVTGHVTGEIRFWSLDYGTGELTVQYMMIDIEHTCEITALRITGAERQDTLLIGDKSGKMSVCKTVQLENISQKELGEVVTELRAMKNFPEDADKKESEGPGATLRSFLPGQGDTVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUX1</accession>
    <name>A0AAD2CUX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49138" checksum="B912CF69248C5CAE" modified="2024-05-29" version="1">MKERSSFRSISSVILIIMLATNMFLIYNLALTTTNVDLEHNAMGQAAMHISGFTQIQFPTFKKKEEEDVMGRLVEELVEWSISKGGYFHPNVEIRRFDPSDPTSFFGAFVNGPVGVNETLIKIPGSIKLQLSKETKHGLGYESSVCELAWLLKEEYDKGNSSEYLPYINYVKEQSFGQIPAMWSPSGQHLLLRVQGDLFMVDDNGFVNPSRMTKWIDRYYETKCLNPRDEENEYLNPFFVAMAIQRGYDKALIPIYDMLNSHEGKINSITRPSIYDRNGFGVYALQDLDKGDELFYSYYHCPDCGHVPWGTPEMLRDFGYVEQYPQTFYLDDNMILYVDQDGQGGYKAWCKEQCPPKAWVQKQLEYLQRVDEDDIATATPYIPEKELNIIRQYHEALTIAFTAVLPIATENDSVLPNTTDDASKRSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CX54</accession>
    <name>A0AAD2CX54_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001680">
        <property type="protein sequence ID" value="CAJ1946464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CX54"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.310">
        <property type="entry name" value="Tex RuvX-like domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050437">
        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF10">
        <property type="entry name" value="S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="816"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="931" mass="103157" checksum="EC4A61505D410919" modified="2024-05-29" version="1">MLLPRRLRPSLLWFSYSSRALRHSGQVHSPHHTAVPSTRLGFTPTWITAHNRLSSGTRIWLSTTASDPLSLEESLEIDPTSPGSFSVLMNDHKAVSPSMLAEVWTPLMLKESKESLSSQGTPKQVQAAISRTIPLLSSSGASGPASASVPFVCRYRSDVIHPLTTQQVHQLQTWISQHESLATLRKKLLDALNGDKDRSKTKDRALVKRILTSISKTELDDLYAPYKPPAKGSILQQIVKEHPKLVQSLEELWSSSSNESQSSIKQDLDLINKLSREYPQEAIVSWLGSKVAAEPKMGEIVSDQLHRYGKLQTKLIYFTTTASKSSKDGKQENSNDKVYENYHDFSMLLRLIKDHQILAIRRGSAQKVLRMSYDIDSTKMESCLKYHLHNSETPLVPSWLRRKSNLFSEVVHDAWSRLLRRRGTQRWWNERCKEAQDRASWVFANNLERALLAPPLQPTRPLLALDPGYQAGIKCAVLDASGQVIKLDTVQFLGKHKDRAVSKLQDLLRATHDLDPSAGDSLTLVALGNGHGTNECRQLIQEAASQDETKIDLQLVNEAGASVWSVSPAALKEFPDQPASAIASISIGRRLQNPLFELVKVPPKSLGLGMYQHDLSEKELEERLHLTSVDAVAKVGVDLNTCSLPILEMVPGLNKLAPKVAKARPFAYRDELLKVTGLGPKTYENCAGFLRVPNGEEPLDNTLVHPESYDLARFLLTQLRLLMKEDERTIKTISVPKEKWIEQWDTEIGQASDKFNVSRERVISVLENLIDSILQKDPRLESSANGKSSTTEVGCIKGCTLLPSDLATNAEKLKEAAPLRGIIATVRNIADFGAFIDFGGPNDGLLHTSKLGPLELSQLLIGQELGVDILQVDNHRISLGLYGLNSEPTQRKPGDTRVKGKPKGSGSTSGSGSGSKRSMSTKTNARKKRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF29</accession>
    <name>A0AAD2FF29_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2256 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1896196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017136">
        <property type="entry name" value="UCP037205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37463:SF1">
        <property type="entry name" value="DUF2256 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37463">
        <property type="entry name" value="GSL3115 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10013">
        <property type="entry name" value="DUF2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1896196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35769" checksum="6DB3EA54225A0C72" modified="2024-05-29" version="1">MQSWKGFSTFLIASQILKSRPSTAFFLQTKRRYSFQSSVIQSGQSDAEGLPGGTKPIKRSYTATPPINMPRGVKKENLPSKVCVVCNRPFTWRKKWERVWDEVTTCSKSCNHKRRAANRGGQKPGNNIVGGDASGVNGRVSPSSMGTQEVSRRSMSTDAAAGSVSAAVECTVVPTEQSIDRVTSDDEMDSPEQLHFSREIADQLSDTDEPFASLMVEDDFMKNVDDPVAYTKQQRKALKKAKKAERRAQRQGRGDPTAGQKTCDMCGKSVNLLIRCMYEPGQADWKMVCGKCWKIASGGVVDGDKAHPHYRYGGLWKNRRAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFK8</accession>
    <name>A0AAD2FFK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000435">
        <property type="protein sequence ID" value="CAJ1934997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1934997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="279" mass="30905" checksum="705252459332B43F" modified="2024-05-29" version="1">MSFQRSTTHTSILAFTAVMMMILTLSLTSQNGGGVDAFVSSPHSAAVRSTFTTPSFQCKSKSPVSSSSSPSSSQLNFFSGYEMGGTDAVNNERKNKSGNTGRTISKNNKDEAANTAGSLDETEDPLFLASLITKGIIILIIKTAKDIVNYPPNLLDQYNRYQQMRNQEIANNNSNIQLQQQQAEEKEKELEDPAMVMSAKMEPTESDTDTTTTSTPTTTPSPYMPLPIELTKTNPFILLAKFVGVLTYKTMHDAIYYPALWINDFLHPPHNDDDAYYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG42</accession>
    <name>A0AAD2FG42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000689">
        <property type="protein sequence ID" value="CAJ1938205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="104" mass="12155" checksum="F547B570E66ECB57" modified="2024-05-29" version="1" fragment="single">MAASQEYTRQEMKDSEGMLASELNKLSLQERNEALEDIHCVGHDLEETPELVQELLAKFDQTVQRQQQHDPTYQEVAKRHRAYVEDPSFRLKFLRANMHNVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG63</accession>
    <name>A0AAD2FG63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000019">
        <property type="protein sequence ID" value="CAJ1927558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1927558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="89869" checksum="CAD34D8F3089CDE6" modified="2024-05-29" version="1" fragment="single">MMDATTIPVSPSFFATIAAALRIDATNVEHSMDSRSELDSHANMIVVGSNCFVLSDTGRTASVNPYNPEYAAKSIPIVDAALLYEDQVTGQEYILVIRNALHVPSMTHNLIPPFILREKGIQVNDTPKIHLADPSSDDHAIKFDEHLRIPMKLHGTFSYFVTRKPTVEQLNDADPNHVYMMTPEEFDPHKSSYAQTEDHLVNYDGEVADARNRSKLLISDIEDDPTMTVCAMSTMRLEEQTLVDESVLEEDDADEGLLGQPFNVDLASISSILCERTLSHRLSTRREVSSMMTSLGSTHAHEDDTDFLFEDMNSELDFEEMLSGDDLFTKIAAMADRKQVDLDEVMASATYAKPSKGVQAAHLAKIWKLDLPTAERTLQATTQKRRHTDNPKMARNYGTNDRMLRYKRINQYFFMDTFFAAKNGGRSTRGNTCCQLFVTDKGYVYVVPMRSKKDVLSAVKQFAKEVGAPDAIICDAAGEQTSKELREFMHSIGTTLRVLEQGTPWSNRAELYVGLIKAAVRRDMRTSNCPLVLWDYCLERRATINNLTAKNLFQLHGKVPEETITGQAGDISNVAQFDYYEWCYAMDNEAGFPSNKEVLGRCLGPATGEGNKMCQWVLKPNGKVVSRRTVRPLTSGELHSDMELKKRDAFDKLIEARFGNTLGRQRKNVPLPEEEEEDEWATYQDDDEFSKPIPDNEDYVDIHGRLINQQPVYDLLLNAEIKMHTDGERISIGKVKQRVTTPEGKQMGTYDPNPALNTIMYEVEFDDGTVRDYGATTIAENLLTQVDDDGYSNTMFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGD7</accession>
    <name>A0AAD2FGD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000069">
        <property type="protein sequence ID" value="CAJ1929002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042125409" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1929002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19630" checksum="E8EB4775E6B776A5" modified="2024-05-29" version="1">MNPLYAIAISIFLFVRSSQGIEIMAADDETPGSMFDDTVDNAKTGMSSMREKVTDATDDMKEAFYSKTEKMGDNTKTGMDNLREKVIEAAGDMKEAVSGNTEKTVDSSPKSTEEAGSQVGDAIDLGVQYVKDATKERSTSEKIRESAKEAGSTLGGMIDSVVQKVMNTIIRPDDSAKCKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGE3</accession>
    <name>A0AAD2FGE3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS1600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000069">
        <property type="protein sequence ID" value="CAJ1929081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGE3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd21670">
        <property type="entry name" value="SMP_ESyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051634">
        <property type="entry name" value="Extended_Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761:SF1">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="51"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="222"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="524"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1929081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="673" mass="74242" checksum="C657188157CF9EE6" modified="2024-05-29" version="1">MGNFMSLATGFFWGSAITGAASFLYFNGQRRPQIDEFSLALEERQKSIRRDVESVNFLSDLVKRLWVHLSPAIGDTIVAAVEPMFKDMLPGPLSSLKFTKCDLGKVPLTLDNIVVHPLKNGKIQCDVDMIWDGACDINLAAGKLKLGAQNVKLMGRLQLIFKPLSDVLPCIGAIQYGFINKPALVIDFTGLGNVADLGGIDAMIRGIIKGAISGVMVLPARLCYKMDVNCDYRDAFVAPEGIARLTAVRGRGFVIEKKTIGKDDIPDCYLKISLGDRTWTTSVIKDDLSPKWLETGDFLLSDYDQHVRVEAWDEDSGTMDSDDFLGQVEFTVAELMLSGRTKEFELLDDNNSPVGAFVTMHCEVANLVSNPTSFSMPPPANHLGGLFTVMVTKAFNLPLKKEDCESFVRIKYGKQEPLLTGIVTHLPDYPYIDALNPVYDVSYVIPITPEMIEGGLPDVTFELTNTWAKQTVLGSLTIPHQEMLEAKDNTIKDTRTIGSAQLEFQVSIQGFDEHSKFDATKVVRKSIPKISATGTTEEADVQQVKVTILGGQGFKIKKKKLRKNDIPDVYCNVKFASSPNVWRTATIKDSVNPIWNESKIYNLANERAIINIQAMDANKRGDDTELGGFRVQVSKILLNGGKMDLELEQGGKGQEAYITVQCELVSGGDKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHH6</accession>
    <name>A0AAD2FHH6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000789">
        <property type="protein sequence ID" value="CAJ1939405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="419" mass="47906" checksum="A7DC1AA93DFE1423" modified="2024-05-29" version="1">MTMDSTIDELNQQFKTLAGLTIAQGQIRLMPAIKKNIRAFIQWCRDKICMGRDPSTTPFPVVDAAKLLRRMKTHEQYVYGSKLMSQQALPQDFTNNVHLEDWCPTFKNYLRTIPGRDGVPLSYIVRMNDAGMLNLHKDFLATYVNMAPHVGEAYVMDNAKVLVLLSKFIVGNTEAEAILRAINIAGNGREAFNALHTHYEGEGILASDIVKAKHTIKELCYVGEKPKMNWSMFEQMLKKAYATCDKHEGREVHSDAMKLRSLQNKVTAPFLQLNKTAINTENGKRLILMTFTTALQIYRTAVREKFPQGTSNATNRGCYLGDTRADNNCNRSRSQNNGVGNKRCNEEEITLSNGEKIWYHPATVSLEHTYKHLPTSNASVWQRKELHTEKVKDYQQEGQQDKPHKHNKWKQSWRNCKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI15</accession>
    <name>A0AAD2FI15_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000258">
        <property type="protein sequence ID" value="CAJ1933298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI15"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="95" mass="10574" checksum="7D43B6A4057F6D8A" modified="2024-05-29" version="1">MNAYFESLLKSNNMDKSQLILVEDKATMPASELLQQLHRDWDEDESSFSDHGLATTRTSCTSIDISARYKVGLEAEGDSGTMEDLNSSSYCSKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIL6</accession>
    <name>A0AAD2FIL6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS7590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="CAKOGP040001046">
        <property type="protein sequence ID" value="CAJ1941612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIL6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1941612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="255" mass="27694" checksum="94282C570F0152A2" modified="2024-05-29" version="1">MTSNIVATMKQERTKDRAALFPLEANPDTLNHFLSLIGFDVQKYQFVDVLSTSDEDLLNLVPRPAVGVLLVKPSNAPSSDGTDSKPGGDTSVTHENIWHISQTIGGACGSVAVLHLIASLQKCLVSGHICKSNSWLEQFLSSTTRDLDEEFHRLHNEAACHQTNQTSHAKLIPGKRVGTTFVALVPVSVGDDGNQGSMRIVELDGRKSGPVIHGNTSSCTFLRDSCRWIEQNVMKYQPDGKFAILALAANKSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIN2</accession>
    <name>A0AAD2FIN2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIN2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="426" mass="47274" checksum="19DE8D17DC0CA239" modified="2024-05-29" version="1">MGKSLTWNEAEPEVFEVPRIDDELIDDAFYQEDEIGEMRHTAFMIECGLEEDPPDGPDVPPIPWKPEDLKKAAEEAEAANKKEEEEKEKKEKPAPKRGPPKRTHSMDEGLVDLEEHLPEAAKKPEPNRGVVATHSGGVFQNRPARRKVPPSRTMSVDAYGSSGQKKTLSIGLARTEKKSIGGPRKIAASKSGSLHAMRKNLDKLAEGDEEPPPIGSPIGSPRRASKLVATKSGNLHGMRKALQKPEVQAVKEEEVSGDDEYTEPMKGDEPTKREPKRGSLVVTKSGTSHGLRRANRPERRDSRDSRSVDSTSTSGDSFLSDFGSSSSDDSDISIETDASEEDEPKPKPKTPKEILQQIKADKEKAKKREKRREEKKKAKKEKKKSEKDGDDSSEKKEKKKKPAKRFSAKRSSQADIPPAFRASFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIR2</accession>
    <name>A0AAD2FIR2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000363">
        <property type="protein sequence ID" value="CAJ1934696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="119" mass="12706" checksum="228A667EAE4C4330" modified="2024-05-29" version="1">MSGVNYTAQKVKQPKAALDSNSLSDRAEEEAEASSARAQEVDAKIKENTVSKTPITMETLAEGDAVEKSSLDAGNLLNKALAASDEADQLLQQAEEALEKSEATLEKHLIDFPDSTLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJZ6</accession>
    <name>A0AAD2FJZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 3 N-terminal helical repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="3">
        <location>
            <begin position="150"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="484" mass="52843" checksum="6DF9BA7714A8189D" modified="2024-05-29" version="1">MADHLAEIAADAAYRISSSSNLVLPPEFVQDPSSFLTMIASEPPSHEALRKLAGPVASWLSNPNSAEAASQVSSLYLKAAATQLKVETTSDGATVAAARKAARSGRMEEMEMLHIQHKAEVVDAVGVAAAHCMSNRISISSSGIIPSLAQIMLNAPNELLSASVEFLQCSLLAEQYRYAARLLQGTWPRPGEGSSVKQVLRYYHLRGMIHLGCNDLVMAHRCFWTCLSIPSDSLSKITFEAWKKMVLVQCLTAKQPQAKGMMRTPKSMPSVLVKLLSSYKDGSPASQTKPARAVGSESAGERRPSQRLSSQRLDQLTAQEALSSYMSLVDAFGQRDKAKFMSIMQEKEAMFTEDRNMGLVHQCLSQLVRNQVVHLSNIYSVVPVSKVVSILGLENESQVPTILLESKVPCQIQPDGMVVFDDNIVAEKNPSLVDFAEWMELLEKVQQLDISMLTSAKYHALLQKENANRKDAPGVGGPQGVEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKD5</accession>
    <name>A0AAD2FKD5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS5585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000624">
        <property type="protein sequence ID" value="CAJ1937273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1937273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="18682" checksum="CB52D4A65D85FC58" modified="2024-05-29" version="1">MVAEMSYSTVSNVIDTWEQVRRRENYEQEVGTKLFQKFFSIEPEAKAIFGFRPDMDLSSDEVVKNKRFIKHAQFFIQMIDRALSLLGPEIEMLTEIMLELGEKHVRYGVKAEYFNSMGTALIHAVKTVLGESEFTEEIRADWLEVYGALSYDMIRGQKNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKY7</accession>
    <name>A0AAD2FKY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="407"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="496" mass="57349" checksum="EE500C29CCEA8E6F" modified="2024-05-29" version="1">MFPPNSAFITPSESNSCVSFLNCGGHSSFHGAALPVFSQRKTGDDSRDEMKPIEDYLASEMNKLSVQERSKALDDIHCVGDELDETPEMIEKSLAEFDEMLQRKKNVIYEMAENQNREYVENPEFRLKFLRSDLHDVSKSVRKMLNFLQHKATYFGNEKVTRDITLDDLNEGDKKLLLLGIQHIQEERDRRGRVVLFFFNRYMGVGTIYNHARVSYYIMFNILSQIPAVQKKGIVNCFYDITKQGENIPKPGISFMLSISDFVNSLPVRFTAMHHCLRAGKDANVALNKFVLGTISKFAPYHVRARTRIHYGTDLELQYQLKGHGIPVHHTFPVDSNGNMREDIKNVWFYKHLQAVEGPSEKDPDIEEHNWVDLLEGYNWDDWPIGDTDENDATSGHSSPTSPPLQDILLGRGKPIQNHSGNVCFREYLKQFSIEYNEAPRHLRRTVRLKIREDLKRRGIRFLQEKDGRWVECSVAEAEKTIGQAFRNQRKQSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL42</accession>
    <name>A0AAD2FL42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001691">
        <property type="protein sequence ID" value="CAJ1946480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="196" mass="22242" checksum="349F3A8CC74A5CA5" modified="2024-05-29" version="1">MGKYTSLKVVSTAAKKAGGSKSKSGSTSKKSGKKRLENASSVDLRQPKDRDPKISNDSGTQEVIDTFRPMIDFGLSTQDFVAIGYDKNSTQIEFGNHVFTKWIDDHNARWSQALPRFDSPFQDFYAKFSVEVRVNMIFDEYDNDWQRVLAFLISIFEDDDKNTKYIWGVRAIALQVAQQIPFSFFDIGLLGDLTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL44</accession>
    <name>A0AAD2FL44_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="211" mass="23175" checksum="F2FDB812AFAADC20" modified="2024-05-29" version="1">MSFQSIIDLNTRTVELIQQQNYAGAIEASSKALRLQKSNLPELDNHLLSTTDNGAHPGFLDRCMLLTETDDNAATAADTFIYGTAICLPPTVTDNSLVSAILIFNSALAYQLYADTQASPVELLLRAKRLYGLAAQLRGVDRNILFQFAVINNSAVIERKIGDKNTATSYFEYLMEIFLVLIDRGCSKQLSQIRGFLNNVPKHNDNSAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL47</accession>
    <name>A0AAD2FL47_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001613">
        <property type="protein sequence ID" value="CAJ1946139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL47"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="234" mass="26292" checksum="C0048CC12CF41DD0" modified="2024-05-29" version="1">MSNDGFGDEEDGDLSLENADGGNGDNPTAENLAGYAPCCTQEYLLLALKPFRRGSKLQRVHVENKGTPAAGTPIQSVAIAPRMATPTPPAKQRTATASSNKKFKKSATNKKRPNTPPSDGQPLESATKKSIKQDYLKSFLSESKIQMDLEVSKTQKRHEETIVLKKEEISQNEKHFRLRFEEERKVFKRKAIEEEASFRKACLAELHELLSNKRSDRYIQKMHPHLIPFSQTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLK4</accession>
    <name>A0AAD2FLK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS7528</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001013">
        <property type="protein sequence ID" value="CAJ1941459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042078692" description="Metallo-beta-lactamase domain-containing protein" evidence="10">
        <location>
            <begin position="26"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="238"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1941459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="639" mass="71155" checksum="3C8B51F64A581E7A" modified="2024-05-29" version="1">MKFRGGQHIFSVVVLHLFCYGNVLSVLAFVPTNKNQCRATHSVVAFSAYNDFDLEQSLDSMTVKDLRQILKESNVNKPRGLLTKLKRKQDLVEYLKTNLVSSDRESILNRKDNISSQEISNDSPSHPISMPKRLGLKAPNVLSAKDTLFQKVYEMYPPLKDQECVSLGEEDVRQLWHPAFRNSNTSGDMDVIFVGTASCSPGITRGVSCTALRLNLNNRKPIAGVPAGPYEGTLDVSAGGTWLFDCGECTQLQVQRTPSVRPSKINRIFITHAHGDHSFGLPGILCLMGQDRDRETSEPVEIYGPEGLRMWLRVAIRYSVSRIVPNYRVHEIKDIPMAPEWEMNRKTGRYFYKGLRRKNSRQKRWGDQGLAGEDRQSWISKADMMNLDPSSRYGEVEGGTDIYPIYNHPKASDGAPIWEVSKADDIKVFAAPMSHGVPCVGYVVEEESRPGRLRNDLVKPIVERNLAALKEAGFKVPMKAMAVIKNLQPGSAFTFPDGTVVTQEEAVEPPRRGRKIAICGDTASARALAGLAIDADVVIHEATNSYLSGIDKDTDMRGVTRDAMIHGHSTPHIAGEFAKRVRAKTLLLNHFSARYKGDQTVESVSIMTRIERQAIIASGLNQTQVAATWDFMVFPIRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLL9</accession>
    <name>A0AAD2FLL9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001074">
        <property type="protein sequence ID" value="CAJ1941758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLL9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="512" mass="57538" checksum="91B2764EC964ACAF" modified="2024-05-29" version="1" fragment="single">SLCGVDLTKYFGEGDILWERWVRAAMGLKSSPYQAVQAIMVAKEIALGDRKDPKNAFRWDEVKLNLPGSSTYDPSLPWVFKIRWSDGKIAADLFIYVDDGRVTASNKLECKQATRQAASRLNGLGIQEAARKRRWGSRNPGAWAGSLVKTTEDSVSVFVSQEKWDKTKLQVKEIAEELSGSTSGSLKHKALERKRGFLIYVTRTYPTMIPYLKGIHLTLDAWRPGRDDEGWKSIGYKGESPTPSSQEAPEYVKAVPRLKDDLAALSALTASESPPIRRVRSKRVMTVFYGFGDASAVGFCSTFQRFSKQGSGFIAEDKIHYRYGHWCTTNGEESSNYRELLNLVESLEMRVRNGELYGVEIFLFTDNSTAESVFYNGNSSSKRLFHLILRLRRVQQEADLILHLLHVSGKRMIAQGTDGGSRGDLNQGVMTGENMLNYVPLHLSAVDRSPLVLDWMRNIWEERLGKLEHLGIDDWFTKGHGRGNFLWTPPPAAADVVAEQVGEARHKHPESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMD6</accession>
    <name>A0AAD2FMD6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMD6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="194" mass="21728" checksum="A77034F6C246F694" modified="2024-05-29" version="1">MWSRQSVPLQLLKDRLCVRFDTLMKSKHRVRTGFGDSDRVFTPPTLIPFQGCGQGNGAGPPIWVAINSILLGMMISKGFGFDFLMLISWAPLLADVCQAAPSPDQSGESIVPKVAKALKWWSNGVRLTGGAIRPDKSFGYLIDFKWNLQQGVWQFRRKQDFKPSLLPKGMSEIVVELDDLDGTPVHLQWLEPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMJ5</accession>
    <name>A0AAD2FMJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="186" mass="21044" checksum="8373BF1D865F0399" modified="2024-05-29" version="1">MNSQSSPLNKEESSHDQRIHVSSNMEPDVAQQFIAEIGFSSFFYPTSNAPRQQNRNKEHASPNSERIAPSSSPIAFGQRINGYNVLDSFQLVKDQNGLSWWYDTSDDSDDDTEQQRCHLTRDINTKARKNQRTTTDIDLDWLSLFERVPQGIGASYSTPPGLAATSYQHKASNTFLFAKMIPQQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNC3</accession>
    <name>A0AAD2FNC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="121"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="303" mass="34926" checksum="F50C9D4A1E7F42EF" modified="2024-05-29" version="1">MATPNRSSTSSNRFQQKPQRKIQSLPWVVMMAFLFGLYFLKDAAFSSFEASSISDLSSVLIGPKKHEESLKVWDWKTPELGDMKQHMEFVRIASELVPRKNNNNNINNKYYGIQHVHRDGLLHSGMGVAVLDTNITMVDAKILLLKRARHLVTCPNAWSLVGEHTHQEETPRDTVLRGIKEELGDAFHQQFVRKGSKTMELLKHPVYANVDYNSDNNGSPIYDRQITYLHAIEMNTPLEELQNMLELDDEVAETRWMTRQEIQDGWMNSNPGEMFCSHELALLLQLVLHRLEDLEREANKMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNM8</accession>
    <name>A0AAD2FNM8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001735">
        <property type="protein sequence ID" value="CAJ1947613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNM8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="81" mass="9275" checksum="763C947054BDF1CD" modified="2024-05-29" version="1">MFNENDVPLERRKVALAFDSIITKKGIQWDVHGKMTGIDQNLHLAPIQTKFIKMKRTKKMRNTCKVSIVSKNTCQISLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ92</accession>
    <name>A0AAD2FQ92_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS12064</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ92"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="106"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1949378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="405" mass="46536" checksum="2537E156C3039A53" modified="2024-05-29" version="1">MAADGITPNEMTSLTDRHSVPYRSSSRKHWFEEERRQLLLLLTEPESSWGASFFFVILIALITFSNVLMVIQTMDSWQFVPTDCVTCGGNVSYMFEDDDQVEMVTVGFCMCPPAPLPITETFVRYIMFFFTVEWILRVVCFTSDPNETKSHIRQLYDYITSMSMMLDFWACFPYYLESINIQSLVSLRLLRLLRVFMLLRLGMYNSMMKTLTNVLTKAVEYLKLLVLFLIFGGVLFGSVVYWVERGHWKYFEPADSYQFVRTAVDGVTEEISPFRSIPKAMWWFVVTATTVGYGDTYPTSTAGQCCAALAMLTGVLVIAFPVSIFSDLWHEEMKNKHGGKDSFDDDGNDWNQTMAPASNDSSKVVMDKKDLKAIAECFRVIREKEDRLSTILSKYNMDGEMKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQV8</accession>
    <name>A0AAD2FQV8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="282" mass="32756" checksum="2A8A4ED101B6DC44" modified="2024-05-29" version="1">MSRQRQQQQGQQEQQEQQEEQDEQQEQMPARPEQRNQVHDQARQDVQQDGLQVQNFLEFTPRQQHAWLRARCDWCFAVADHFQPMTYTTVEIAINMLCDYMMHSGRLHELPMGHVLRCSTAASLRIAMLLNEGNYMTLQQLIQIGQHRFIEDEIFESVFHIYQCLGQDILSPETIESHAYNYLVFLESDGNGSIADLWQPLRRLVRLASRDLLFLQYPAQKVGLAAVVVALRINNANGWETRTMALLRALNIEEYSTEAAIVSEIGSRLLALHHRYTNADEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQW6</accession>
    <name>A0AAD2FQW6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQW6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="102"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="473" mass="52434" checksum="0F6F84E7EAC9E8B4" modified="2024-05-29" version="1">MIIQREDHLAGGFGNTELLQRLESLPTNVDTAVGRVSRRCQQRALSPPLPYMGSFCKALDYPCDEENPDGFVILCMAENKLVTDILSKRLGADPNIAKVAFADESLYCYTSSLGLPVARQAASHFFTKRFLSSNALQDSIVDPKNIGIASGAAGAMNSLYFALGDAGDVALIPRPYYGGYDFDMSIVSQITPFGFELDAPTEGPTEADLDRAFNDAQSKGLTPRFLLLNNPNNPLASVYAPEVIRNAVAWARNLKLHIIVDEIYALSTHVGHGFQSVVRILDNDLRDDVHVVWALSKDFGASGLRVGFVYSRNETLLQAMSHLNTFSSVSNSTQAMVAELLTDDTFIDYYLKESSIRLRQSYESCVEKLVEMGLPFIPPQAGIFVYVDFSSILPKKTKEYEAKLSQLLIEHARVILTPGDSMKDPTPGMFRMCYAWVSPDVLRVGMERLSRIVTKIRRLDWEDLDETTLSGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSZ5</accession>
    <name>A0AAD2FSZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS12762</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM163 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="12">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1950798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="253" mass="27321" checksum="0BEF3E5B841BEFD6" modified="2024-05-29" version="1">MNFTGCFKNPTAKHAFYLSVIGCAVEGLFTAVGLAGYFVLGSPLLLVYGLENVVDFISSAVVLWRFYAPGELTKARELELASREERAGVAVSFLILLLGCLVVPAAVGDLEEGAPTDQEVDAALELVMIISFLSVTIFTSLTYLKLKYARILNSESLHKDGLCSVIGLLLSTLIFITSWLINKYPILWKIDAYGAMLCGSIAIFIGSHGIITAVMKKDLPIFSITFWKGETGTEPTNLAAGANEPKTQLSEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUE5</accession>
    <name>A0AAD2FUE5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUE5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052392">
        <property type="entry name" value="Kelch-BTB_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46375:SF3">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46375">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042035263" evidence="1">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="391" mass="42347" checksum="34FEAE019315952D" modified="2024-05-29" version="1">MKIELLAFLCSALVPAATTALESWTFAEVDAEVPIAVSDHSGVRSPDNGLVYLAGGCDHPSGNVWNADFATFICDSITDAFFAFDPATKTFETLESLPRPRYRHSSAIVDGKVFLLGGRTLFDDLIPEIDMYDIATKTWSTPSSLPAEFAVSDHAGFGSSDIYIAGGYDQNYTAMSRVVKISGDGQTFTRVGDLLEERGDVFGVATKDGTKAYVAGGFTHTNWCKPLTSAEEYDFSSETWTSLPDLVDARGEILLVENRGHLYAIGGEGPLDEGVCASNNYTIATKTVATDRIEILNDGETAWKILEDFPEERFRFAAVGVEEDDVIYTFGGQVKFDDSCQCFKTTNKVFVYGKPEDVADKGTIVEADSGSAKSHYAAVAIFALGLVVTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUI0</accession>
    <name>A0AAD2FUI0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cGMP-dependent protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS14149</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001831">
        <property type="protein sequence ID" value="CAJ1953549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUI0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF143">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="7" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="173"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="342"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1953549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="83211" checksum="BEAB6F5E8355DF50" modified="2024-05-29" version="1">MRTFKGKWGRKCKESGGTADFAYMFVKPTLTEEQQREMERQIRESKINQGSLLEAGKGRPSSAPTLKPIKTNVGTNMQALLNADQKRMTVAEKQEYLKGKFKAKHYIGDFGKLKKAKRNPKSKGEKTEIPPVSLRKVCAPQFEFDLRQFAPKETKKTEWQNKILKKVIGASVVLRDNSKKTEDRLIAAMKQIKLKSGQVLSKQGEMDEKDDKYYVVESGRLEFHVDGVTVDTAEAGTAFNEERLLYRHANNATIKASEDTKLLELDQATFRGIMQQEEIKAQKEKPKQKEKPKPKPLPAKKEKRKKTRTIAGDWDLSDSTIFQEQEKARFGVKKHASSKEDLEFVRLLGEGQFGEVWLVGAKLPEFEEKQQYALKMQDITDDELREDPTDAIWKEITALKIVHHPFVVNLVHVYETEDSIDMLLGLIRGTELWDEVHREDEPDVWVSGFSEARARFYTCVLIDTLAFLHKHEFCYRDFKPENVMIDEDGYPILVDFGFAKHVAEGDKTFTFCGTPNYVAPEIIKLLGHDRNVDYWALGVVIYEMVCGENPFFYEGMEQFALYQAIADEVPYDMEGDYTKEVIDLCHKLLKKDPTKRLGSNHPHDILEHNWFRGTPDLSEYRAKKVAPPPLIEETISFEEEESESEDETPIKARLLEDDVDGSNLEEELDLFKEEDKPKPKIKLAPFKATNKGALKGYYAKEKTKEEKYSSKERRSMLSGTLEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUK7</accession>
    <name>A0AAD2FUK7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001842">
        <property type="protein sequence ID" value="CAJ1953805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="484" mass="54479" checksum="EB2D2F35CD7FDB2B" modified="2024-05-29" version="1">MKSPPRATVTGTNHHAPPTPAATNNNGNQDTSQFILQTILQLTEPMMRQMQATAERLAQVTERLQEKAANPPPESRPRTTTRQLEPDLHGARDRPIQYNQGATPNGGEDEVPRGPNGEILINQHNPLVRIGQVDSSKDDKDKIHGLSIFDSQVDRAMMPEALLRSQYNKGLYDVTNDIASLPGTCSPKGGGGDVDVNTDTTDIMQQFLETVESSKSPSMKTTITAIHYPKTSRHGLSLIKSKADLFKAASTIAEDKELTSRNQQLRIQSYLHDRGYMKGFIDNYLERSLLCLIIQETLTNYTALINKIRQKRIDGMSDVWKGSEAYLLLSHHSKELLRIRVHSTSKRLFQNYIYLRDAQAKNFNSNKITEKTITNVREENRLFQEALDSRLEALVEERLAEHLAKNKKGAGKGNDEPKCSWCHNRDLHIALGIKHTPKACPLKSHPTTWAKKACRKVLQTYKADPKRPIAAEIVKEVLEGWKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV25</accession>
    <name>A0AAD2FV25_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV25"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="17607" checksum="FF791EBFFEBD208D" modified="2024-05-29" version="1">MSPTILLLPQLVLTYAALKKQRPSSSLTFSEVNDTLKELSSPPSSPTNLSSSSSSRSGPEDRPFNLQVPDLPVFSGRTEQCPGWKRKIMPELGKQALWNVLDSDDYHAKNPQISEAIFSAIAAALSDGLASPLSKQLESAKEFNARKLYLVLEKSFNTLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVR5</accession>
    <name>A0AAD2FVR5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053240">
        <property type="entry name" value="VTT_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46826">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46826:SF1">
        <property type="entry name" value="TVP38_TMEM64 FAMILY MEMBRANE PROTEIN YDJX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="4">
        <location>
            <begin position="222"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1953621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="403" mass="45479" checksum="1F2DEB8F95197B94" modified="2024-05-29" version="1">MGATAEPFVQRTLKDCNHQDVFHIQNSGTQRCIALKSHAEESGRTELRAIMETCDDVAKRQQWTQIAADFLVRSHFDSSKCLFPSKSSIVALVDCEDENWMDASWEKYSDKTIRNTDHEDDCWDEHHGKYLVLSECVANRQEQLWTSFSSDPSCPDTVIRDKSRAGNTTDSTNNTNIASTDNSTDSNSWFNPQAIEDHVNALGPWGIYYFGLVYVAIEIVCIPAVPLTITAGYLFGIWKGFAVVLISAGTAAALSFTIGRTLLRSYVLRKLEGYPKFKKLDKALGKEGFRVMFLIQISPFFPFAMGNYFYATTSINFWSFWFGTLLGISPGSFVYCYSGHVGQTLLSDASGMIYPWYVYILFLLVVIVILHLIATTANRIIEEMNEEEEEVDNEHLEKLTPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXZ1</accession>
    <name>A0AAD2FXZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXZ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33618" checksum="94420187A5D7C76B" modified="2024-05-29" version="1">MIEIFVYKGGNQVIPEDVELVRIDPSVKIIEKWAFEDRPKLRYVQFSEGLQKIGSNAFSNCVSLESIRLPSTMTAVHKGSFYNCVSVTSVVLNEGLEIIEKDAFSGCGMELLWLPSTMKYVRTGAFDSCKELKKVALNEGLVKVENYAFNLCDNLETIEVPSSETVIDAFAIPEKTSQITGKYIPFWDQVHYRYEQGEKARMEKYGMNSVPIDDSEMDDSTMMNSKPSPEDTSSSRKPLAIFPAPTKKRSKETKADIQLMLADKQEQIESLKKLLMSAERERDELQTKLNEYDMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY71</accession>
    <name>A0AAD2FY71_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="523" mass="59770" checksum="5288FECA28648CF8" modified="2024-05-29" version="1">MPISYDKKTAKNGTSDTEGHCSTGRLMTIFVLIMAIMMVLILRIVTMIVNPVTRKRNPTSGHTRWKNTTNTFSNGLIDSQAIHKAIFDDNTDKTNMRQSPSSTKEESICDSLDENMPVLLSILRGEEVKVYNDTQHGEGPDFRIQSLIEIDMNGYQKPFASDIRVSATNGNTTSTDPTAAKIIIIKGFNRDLIDRVFRKKHLYFIGDSTSRNLFVALRRLLNYIQFGAPKDQNETAQISSQSRTSSENDNDLEYDKWTDSLEILFAKAQKKWKSGDSLPPYMIPAERTYLRILDVSSIYVESPAQRKSAEKTNLREDFSNLAKSTLVNPQAIIFNAGLHLLQLIPNRKLSHYKYEGWSQYESILETLLQVSIDSEAPIILAKSTNRVCDSKFGPDYRNYAKAYTEKDEKTLENCEKIVKQQEKDKKKEAHEKGYNITGLGKSQREEICKFGTLNDEGSLLLNQRMTKFVEQKRMTMPNRLRYFNDHDIELCNYSRGGDGRHYKPQVFVRLHLLAIMLDCMSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYJ3</accession>
    <name>A0AAD2FYJ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS16433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYJ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053238">
        <property type="entry name" value="RING-H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF627">
        <property type="entry name" value="OS06G0192800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="365"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1956863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="415" mass="46698" checksum="724ECE7226C61F70" modified="2024-05-29" version="1">MGSWCVSSITEMNYLFTGSSSFNDNISSWDVSSVVDMTGMFYGAASFNQDLSLWDVSSVVDMSNMFVRASSFNQADLSSWDVSAVTDMTAMFYGAYSFNQDLSSWNVSSVTAMKSMFRDAHSFNQDLSSWDVSSVTNMSHMFFYATSFNQDLSSWDVSKVTDARMMFFNAAMEEPAVLCGWSDAWKGLLNCNGSASSNSNAPDLVPGLGIFGGIIICALVAKYYDMHRSSQRSVSAYEDQEQARSRHEIQQTMTARRRQQRENNTGRQQGLTDEERNHARYEQFVASFYFHTVLSEKSNITANNLRRLASSKPDEENPSPAANDHDGNADASVVDEKQSSSWRRPSSWRRPYSWRKPSSANKEECCICLESYAVGETICAPIATECNHVFHKGCINEWLKYNDKCPLCRVELLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYZ0</accession>
    <name>A0AAD2FYZ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS16829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001948">
        <property type="protein sequence ID" value="CAJ1957677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1957677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="574" mass="60614" checksum="B2C7CF0702C20CF9" modified="2024-05-29" version="1">MIRSNLLSTKVASRFAFKNNGSLRYMSKEIKFGVEGRAAMLIGVETLADAVQVTLGPKGRNAIIAQPYGPPKITKDGVTVAKSIDFEDPFEDMGAQLIKSVASKTNDIAGDGTTTATVLARAIYSEGCKAVAAGLDPQDLFRGINLAVDKVVKTLGEISRPITSKEEITQVGTISSNSDAEIGQLLSDAMERVGKEGVITVQDGKTLENELEVVEGMKFERGFISPYFITDAKTQTCVLENPMILLVEKKVSSLQQLVPILESVIKSQSSLLIVAEDVESEALATLVVNKLRAGIKVCAVKAPGFGDNRKATMQDLALLTGGTVISEETGMKLEEVTPDHLGTCKKIEVDKNNTVILDGGGDPAGIKERCELIRHSIDTTKSDYEREKLQERLAKISGGVAVIRVGGASEVEVSEKKDRVVDALNATRAAVEEGIVPGGGKALLYCSTLLDEVADGAKNMDQKIGVQIIQRALRAPLSTIAKNAGEEGAVVCGELCKKGVEISYGFDAANGIYTDMFEAGIIDPTKVTRTGIVDAASVAGLLTTSESMIVDKPQQGGASGGPPMGGMGGMPGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ83</accession>
    <name>A0AAD2FZ83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS16978</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12974">
        <property type="entry name" value="Phosphonate-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042204950" description="guanylate cyclase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="11">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="640"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="1055"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="677"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="679"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1957991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1340" mass="148912" checksum="CF700E8208FE005F" modified="2024-05-29" version="1">MRELLSSLCIALAALCFIPRSNSEYLDMEGWTADKHWAVGDINCTHGLREFNKHTQKRVYTVGVHAPSGIDKAWTEFNMTFETYLTEVVGKRFDPPIEFKMKPSEWPLLDWIDNAEDVDFMYSDTGLYSCIGTELGAQPLATTIASLESRGREYELDSYGGTILALASNTAVNTIEDLKDKVIAGQAFSVFAAGQSQFYVMHKAGLDYIMDPKQVIFTGNHDETVQGVLSGRWDVGFVPSGRAERTVDEATGEYIDSNIFKVIEPKIAIMNNGDLFPFLHSTPVFPEWPLFAKNEVDGIVSEEVAIAMMEFGAHKRVGKLMHQCVEDAETAEELELCNTMPPVYFDPAARCDTTRELAELAYHAGMEGHHSGMRPAKSHFQVRTMQQDAGFIIRDDTNGDWRCERASRTYFGITCPEGHYKIAEDKFDKHCDKKGLPCPEGATCYCRPCIKAYEVDVFPWDISVDGAVPEEHDRCDKMSLCGQVEQNEDVVFHAFDNMERSNATVTALVHLGQESRYLDVTRNAGGFNQYEFTFSHRKRGVAILEVFFDAVQIPESPFRIQVFDKECPIRGMVASEDGVCECSSSAIDIFGECVSEGVFAGIVSGICVLIGFVVALFYIAYKKKKNDEVWHVSVEELHFSHPVEIVGQGAFGVVLLAEYRGTKVAIKRVLPQKDKTKRSGSVASVGSVGAPSVSEGDEQEDIETGEAGGGAGGTTSGTTSGFGDLDFLNRLSFNARKRGGFGRLFRGHRKDDSSKYNLSILGSVSAGASISRGIATWLFPSCNETARRQEQFKEEMRLLSRLRHPCITTVMGAVMNGIEPMMVMEYMENGSLYDLLRNESFFMGGEIILQVIRDIAQGLRFLHSSKPAILHGDLKAKNILIDSRFRAKVCDFGLAVKGKNDLSGTLYWLAPEYLRRRSEYNSTCDIYSVGMILYEIYSRKTPYEGEPLRKVLRKVCDPRINYRPAVPGTCPKRMTEIMTRCWSSDASYRHHAKDLDMIFGEMTSRDADPLLEETNTRVRTEVATGDMLYKVFPKKVADKLRHGEKVEPENHDNVTIFFSDIVRFTDISRALSAVKVCNMLDRLYMAFDELSTKHGVFKVETIGDAWMGVTNLEGNQEGSHAKRVAEFAIDAVQAAGKVLIDEDDPTAGYIHIRVGFHSGPVVSNVIGSLNPRYGLFGDTVNTASRMESLSVSGRIHCSDAAAKLLKEQAPGLPLYKRGKVAVKGKGNMVTHWVGKGDNAPVAAGHFDEPRPLVNFNEKLQILTSPPPNTGKIFRSPAAVTPKHHDEIAMNHPSRRTTMTGATKYAREIPTASEVHKPIEVHKSPMVQATPVISFQRSLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZQ3</accession>
    <name>A0AAD2FZQ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methenyltetrahydrofolate synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017:SF0">
        <property type="entry name" value="METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40561" checksum="FF85854A387D1640" modified="2024-05-29" version="1">MTQPQKACSKGSSAQEKEVFDEVTYEADRLAKDEEAMQAMKEKSEEEFSKLRTPWKWTIRKRIWDLMEAKDIAQYPRPVHHRIPNFVGADEAAARLTELPEFQQAACIKVNPDTPQRPVRHAVLEQGKTLLTPQPRLRTGFFSTLSMDTLPGVEINGCTNSKGVAKFGTQVTLHDKYTVDLVVVGSTAVCPNTGARVGKGEGFAELEWGILSQMGNLSAQNCLVVTTCHDIQVVEPDSEDGGIPADSLTKHDVPVDIIVTPTRIIRVPNRAPKPSGIMWDLLSPQKLAQIKVLRQLKRDIEERDGTQLPSGPEEVLPPIASRNNRSKNNGQKKQTNGKGRRRRPRNSNNKSGRTSNNNSQRETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G082</accession>
    <name>A0AAD2G082_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G082"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="28304" checksum="B5AB6C5C8486FDA8" modified="2024-05-29" version="1">MQQHNGRHKPYVTESSLNVDSEADIELSVPFVEAAPIADGEAVTPPRQGMPAPPSTVVRVQVTAPAMLPPGYVMQVLYQEKDETGNFKDTWKKGIIIIPLDGGGVNKGQVFEAETQPFDTVKQIHGYWHGNEFNVDECCCSQTTDADFCLLSWYCPPVAWACLYEQLVILDKQNAGQNSYRPRFVAKSIGFVSLLFLILSIVPKTSGAVLSRVTPDDSGFKGPFAVVFFGAWNIWAYYSSCFCLLGFWNGCEIKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0M4</accession>
    <name>A0AAD2G0M4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001986">
        <property type="protein sequence ID" value="CAJ1959275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0M4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="758" mass="87059" checksum="5127124A9C06E435" modified="2024-05-29" version="1">MNRSGSSIVKKHLNSRTVNNTTHILGDGATNAEDELGHDFKQRLQKTLSHEKTDKTRRDYRNRILRMTKYFQQKCFRYFEVGVRKNTSAEMNDPAMYFYDKYEYDLIYAGLNVDYVLKFLMDQERTAAGNLRTKADMQKFRDAIKWGAQIRGEALSQECWDKLDLYLFSYKRQVAAGKGNGDVQTKEADPITKELYMLICKWASEDGNTMVDFWTKTQWNCMSRCGNIDYLGFSNFRIVLDAHAVTHDTTKKDKDGDRCFAKHIYANHEYHYLCQWTAMGNYCALYKNELGQTQKLFMWNTKDGSAAKKYQEQLKALVNKTEERRNIVSSHCRKGHFNAYGLRKGAASYASSGTTCAPSLSSIAHRGDWSMGSVFDIYWRFLPVGDHYLGQILSGKDPMKPSFKTLPPHWKMANPMGHPLIREVMNANFGPILKTHSEADYDPTGLLLRCLACMVWHAKSFQEYIAHNPSNELVKVPFYNMRGSEIDALQQLITVEPTPDVMTTVTGVPPHIETTCQMKAIHDNLIQLLAQTRISEDNQKQRDEQLKADLVAAVHHGIEQNAISNGNITAKGINDIIQKHQDATNKQLTEHLQAMLRSLPPQFQGGQPAQIPPPGNQVQQGGGLLLQKPDQGKYFYTERFWSVPEDFEFPPKPNLPQALRCWLKGIRYGNNYVKPFRQLRPKDLPTTALQSQMRVEWQKFFKYLENNGLEMPSNTSEEVTEAQLERTTDEMWDLLEKKVSYAFTRKNAKSHCLSPWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0Q0</accession>
    <name>A0AAD2G0Q0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/potassium exporting P-type ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS17536</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0Q0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="896"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="948"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="978"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1011"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="13">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1959112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1080" mass="116701" checksum="B1C87D7D9B444968" modified="2024-05-29" version="1">MMQESSMINDKPQLEVQQPNWHAMTKEEVFSELELPEDHRTNGLSTEQASASLEKYGRNMLSSKKKKTLLEKVWEQVANVLVGILLFVAAISIVRVFTDDPVTNGIQVGIIVGVIIINTAIGIIQEGSAEKAAEALKAMLSSDAIVLRNGIETKVPAEEVVPGDVVVLSLGDRVPADLRMIEVSQLASAEAALTGESVPIDKTVDVIESENPKSVPLGDRHNMCFSATLVAQGSGVGIIVATGDNTEIGTINQLVNKVEDQKTAVLEQIDNVSKWLALFIVFTAIVAFLVSFFTTDTDDRDWLESLSVALVCAVAMIPEGLEAIVTVSYAWAVSNMADKNAIIRALPAVETLGSVTTICSDKTGTLTKNEMTLVGFVTSNARYKIDGDSTERTNKNFVRDDTYMAKRADHTKMMKTRDVLKSGPGVSTHDRFGKKEKDFPFTMRGSVIDKSLVSDHGNQEGSEAADKADGHESNDNFPVGAGESPELSFFRQGLAGGVLCSKCTLGKDGGREGEIGNPTELSILRASYWGGIEVNDMKDASPIIAEVPFSSDYKFMATVHAPKPENDGQGKNDKLIIHVKGAPDRMIPLCNKQFKAGMLNETEDINHDYWIEQIAILSSHGLRCLALLRGELDLGAVQQGDPLGPEFVQDKGAWLTIVGVCAIMDPPRPECVDAITQAHGAGVRVAMITGDHKDTALAIGCMLGLVNEEHNSAITGPELDAMGDEEIKSAVQKYNVFARASPQNKIRIVKALQSQGEVCGMTGDGVNDAPALKAADMGVAMGKEGTDVAREASKMILADDNFATIMVAVREGRVVWDNLRKVLLVNTPINNAQGMSVLFGLVCGLKDTPLTAIQVLYCNLICAITLGFVTAVEPAEDGIMNLPPRRVGKRLIGRYLFLRIVLGTATLVACTVGSTFWARSLYLNGATETSNYYYDIVLPLMRSQASNTLTFGACSITMSARFAYNSSFGTRSLYGNKFAWYSLAIVSILQVAITYTPGLNSAIFGMGPMKAEQWGITALFSFIVFLVMEIEKSIRRFLLARGADVGDSEYGFFDDAEQMPNQDISLPKGASHLNLTTLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2B4</accession>
    <name>A0AAD2G2B4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18582</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2B4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1048" mass="116602" checksum="D7787A2FBF5D3E74" modified="2024-05-29" version="1">MSQYYNFDENVFRDDVEDALQTVEKILDADRRPRPAEEVHHKYENKYELANYMTNISIVAQMNVLERLGFTPQIIQQLEDTKTKTTTLRFEASEICTFLKEQTVDVPDPYAVETVKERTSVLGSTPFKSKSSTIHKVIRKVNEYHWTVKAHWEITIFSGTEVDKKIMLQSRDSSTIVVTQSKDAPMEKVEKHTPVDLNLTWMLKQIDMENKATGFSIDVTKANTPRRNEQVEASMNFFCSRMNSWLYNVKSHFSRNLQRIISSIHNPAIPPPSHQEKLARQCSASGLFQPILPILEENKVKDGESVNDELLILEGGDNADAPQSVSTLALPSGISHAKKQECQLLLGKDTIQLLNAQVKSIDTKLKSLNEVFPASHQMKLFSIAEATVFLMLDHSEKLCLQYQHAIGYLEKMLENQLVAAIGKRVTNDDLEEFVRFHNAKFLTIPPKPFCHAIGRPNRFPYGVLSIESKGDSDNTIPIETMMRPVQMEAPLEVPLNAATTLQLTGNTYLHGWMHQRSESGGTNKSFQLSARARQFSSFMLVIGTMAGPNKLNPKDAIILQNKDEVLIPLLLEEIPSAKEFKDAIESLSPEQQRFAKSFRGMQLESSVFGVAVIQIKPQLEALLGLPEDSLAKEIKLTEDLMELFVEYQVPSDLLSYDELAVAVSTSEKVDIVRQNVKAVMSVVEGTKEKQLEAKTMKAEMAVASAAQELCFEQDTIPSIGASYGDYSPPPCGSMRRSAGGGGGGGRGGGRRGFAEVLGLGANFSRAPSREEGCGSPPPQVLLGRSKGNVIPKNRQLDRGAPPPPNSTDAVWIKQEPDYDWSSEKPKDALWKKEEPNYDWSGAQPFERPADGLVTLSTTSRDDDEPGEYKKQNVENNIVPNSTSKTKRSPSQAVDFTSIPKTLDATIEKFDKDSTLRSTKLKTMDTWSRKRQPDLLTKPTTNTLAAKDVKSESNKAYDLLDAISRSGSLPIAYSDLHVVVCVTHCFAKDVMATVVEDNVNPIEKLEMSTLLLGSAIHGTKPIELIAEEANRARFQSSFPLMLETEGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2C4</accession>
    <name>A0AAD2G2C4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2C4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042128879" evidence="1">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="13526" checksum="8CEFF7CBE2A5D65B" modified="2024-05-29" version="1">MKFTATVLSLFAFMHTIDSFGINQQKVAKTSEIQISRSNFLALVGAGVTVAACSVPPAFAKDSEAELKGTKKDPNFETCLSTCMYECTKPKGVEQKSRKECLPECKAKCATNKNQLLLGDPKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3D1</accession>
    <name>A0AAD2G3D1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS19137</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3D1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000027">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041967650" description="P-type Ca(2+) transporter" evidence="16">
        <location>
            <begin position="23"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="891"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="968"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1961317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1140" mass="122810" checksum="BFFCD682F9FE83DF" modified="2024-05-29" version="1">MMWCIRYLLGVLMLACLQASSAIAIKYPGAFASSFISSRLSRTTGRRYHLPMIRGGGSDFSEEVAPAKLSYNASAVDAGSLQISDLMEQLETNAESGLSQEQVVDRLELYGQNKLDSAAKPSIWKLIAEQFDDRLVQILVVVAIISGIFSFLEHSEGESLLQSFVEPIVIVAILVCNAAVGVWQSQSASDSLDALQEMQPARATVIRNGEVIGELPASELVPGDILQLRVGDKIPADARVLELQSSTLQVDETSLTGESVTVSKLSGAEGQNDPGAPIQSQLGMVFSGTMITSGNALAVVAQTGMTTQFGKIQQGVTMAKESQQKTPLAQKLDDFGQQLTLIIGGICIAVWLVSIPKMNDSSFANFWEGAIYYAKVSVALGVAAIPEGLPAVITLCLSLGTRRMAQRNVIVRKLPSVETLGCTSVICTDKTGTLTTNEMTAVSLLMLEGKGQLVEHVIDGTSYSPIGSVDGIDQDEIDKKGAVADIAAVAALCNDATILGNDDAWGEQSHDEDVVDEHGNTVQKLHHGGSNKKKNSLSNIGKKIYDRTGEPTEAALCVLCEKLGGMQEYTHGQHIAQNGSYHLHVPPSVLASANVDMWRATHPRMATLEFHRERKSMSVVSSFGDKKNRLLVKGAPNLLLERCTRIKDRDGKVTKLTGAMRWEIQAKITELAQRPLRCLALAVKDGKDLEKSLARFDGKDSSKHPLLKDPSKYKDIESGLTLVGIVGIKDPARPEVADSILKCSKAGIRVMMITGDARDTAIAIAKDVNIFDSEAPNDSLKAFEGREFFSKPEEEQLEILKKDNIVFCRAEPADKQRLVKMLQSLNEIPAMTGDGVNDAPALQQAAIGIAMGTGTEVSKEAADMVLADDNFSTIVSAVEEGRTIYANMQAFICFLISCNIGEICAIFFATLAGFPEPLTAMHLLWVNLVTDGPPATALGFNPPSPDTMDAPPRPSDEPIMTKWLLTRYFITGLYVGLATIGVFVQHYVHEGISLSELSNWSQCGTVWSPANGGAGICGALFKESGRMYPQTLALTTLVVMEMLKALSAVSVDNSLLQVSPFANKWLLAGVSGPFLLHLAVLYSSKLGVPVLGEAFGMVPLTSSDWQNVLLWAAPILLVDEILKAIGRNLKQKDFKKSISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4K3</accession>
    <name>A0AAD2G4K3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4K3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="459"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="962" mass="108131" checksum="5C07B3B9D75BF365" modified="2024-05-29" version="1">MMKARFLGFSLDSGDDFTYVIVTDPDSDKEPRRIFTRSVIRPRHVREAAPVVVRKGKTKFEIYKKDERTILEGIADPDFPPQLSERAPNPLLTIQEEPEPLDTVEEYERAIEEVYGPPPSKRLRTDPTSDDALLRTDLEELQPLSVKTVTNSASKLPREQAEPTIQPPRDQEIAAAVPAATVEATTDGPSKPAQCPAPVTQEEHTQVTDQGEHASESDDDASVQSAGDDSVHSADGDLDDHHVTPESLDVHLQNIAGISDDEDLFDSVNGHEFRKGVLFLRILWKTDETSWVTYRACREDFPYETAKYICANKIGSCSGNHKNGPHQRWARTFLKKTRRVMRRFVKYYGYSKPMKEGQVFCCPEEDDSYQIQYTKRFKKSTPRQNRRAKKPGRLRRPLPVKYGIPIPRTVRQALAIDDENGNHLWREAMEKEIASLIAMNCFTFHPSDYKPGPNSQFAPLRMIFEAKQDGRRKGRLVCGGHLVDPRGISTKSTVVKGVSVRLLDMIAHRDGLTILHGDVGNAFITAKCLEEIHSTAGPEFGEREGAVVTINKALYGLRSSSRAYREKFAAFMRTIGFEPTRYDRDVWMRLREDKSGYDYLCTHVDDFKVVAKDPQRWVNAIAGAFQLKCSGAPDYYLGMDYYFDDANKVWLTGSKTYVEECIRRIQALLPNGSQLCVHYTPAPSEGPASHPETDTSDFLDDAGKRQYQMLVGMAQWAVTIGRMDIAYAVASLSRFSAAPRQGHLELAFYLFGYLKRFPSKQLPVCSDPLEIHPTLLDKKGDFIPDFLKEYPDAKEDRDPKEPKAYGKPVQTSVFFDANLAHDLQTRRSITGLLVYVGSTLVSWTSKRQGCIASSTYCSEFIAMRAAVEEAMSLRYMLRSLGVPVEEPTNLIGDNLGVIQTASIPEADLKKKHVAISYHCVREAVAAQIVNPIWCDTSENWADICTKALGGVKLSAILSRTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6L6</accession>
    <name>A0AAD2G6L6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6L6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46277:SF3">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46277">
        <property type="entry name" value="OS03G0850700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="108"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="290" mass="34090" checksum="68A4E83DA8E3C3FE" modified="2024-05-29" version="1">MTKIIFPKAGLFLKQHQKQNDAKDIDGGSSFTTEIHSDSSLDGASTDRQNRKEQECIRKLKEECRFANISASDIIIFRFACFYDFHFDKARTAIVQKFDDLHLNLRMEDKLCEQFQNKVIFPLPGLMTKNKKHEVLYFHASRHFPATMDTEMLIKNMTYIFNDMSLTKEQCRNGVAMVIDLNHWTFKNFTPECSNKFFKALQYQVPTKVEAVYIVNAPNWFPKMYRHLFKKMMAKSFAKKVLILKHPQQLQNHLMDGCEKYLPVEMGYWVDSSEIIDDFVDMKLHSESNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8V3</accession>
    <name>A0AAD2G8V3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1810 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8V3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.380">
        <property type="entry name" value="Protein of unknown function DUF1810"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014937">
        <property type="entry name" value="DUF1810"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036287">
        <property type="entry name" value="Rv1873-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08837">
        <property type="entry name" value="DUF1810"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140736">
        <property type="entry name" value="Rv1873-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22126" checksum="9F41EA5D17C5F6B0" modified="2024-05-29" version="1">MRRKRTSDSDDSLSNNSSSNSSASQSGKNSQNSNPGDSSVSKDHQQSDPHDLIERFVMNQKARFPHAIAEIKQGKKRTHWLWFILPTPPYIVDGKERGSEMNRYFALRGDAPQAYLKVDALRYNYLEICRAMECQLKFGNTFRNMFGPYDCPKVISSLNMFNETALQMKDDELATVCSSLLSMDKKKNPNSTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCV6</accession>
    <name>A0AAD2GCV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002413">
        <property type="protein sequence ID" value="CAJ1968884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="615" mass="68724" checksum="CF40524290F21ECE" modified="2024-05-29" version="1">MTEESDWELVSDSEPSDWSAKQVHVELPTAGVLPNQTTSESPNISSNSTNSFSVIDGMDPLALHSDTGSSISSFFQLSSNESLMGSSICDQFDLVSLSSGDVCFRCKRCQARNPIGTGICNICHLAQVANPCIGLDEQLALAQQQREEKIALQALQFEERQLQNLMNDSLSDKAAYLAQKLMTQLEPHNSILKDYAKFDFVNRSFAFLGKAYGLLQRRSILRANLNLVCGYVMTNQAQGTYLRIHGFRSDMKVPVYRTMANALEDFDVNPSIHRHFPPSSLSPISENDVMQRPLVSIWIVAAVGSKISLGGQTKSINVPGDTIFPLACLDAISMDAKADEIDSLTKVLFQVIDDTFVDGLHMKVKSIATGSTQDPEALHQRTTKPIATSITIAHARRQMMKPIASSATIAPGREQTTADTSSCFQAGSRGKKYDIDERWRSQRGYPPNVPKRSNPQTMRVHSNSERTSGTIRRIDQNAIDKYRRSRYGTLSFFCSGVSMKDLAGLDHDTRTSLRFYNFPVSRSPEWLLHEFACHGFPKARFNLLFLPVILEGQRCGPLFLDFVNYRDIPEFCFLFCSTKNKSGYQFQRPQYTKHQGKAALTAYFQTTPLLNEFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JG63</accession>
    <name>A0AAD2JG63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dynamin GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS10755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JG63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="53"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="675"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1946622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="86342" checksum="F56658CBB8B3C92B" modified="2024-05-29" version="1">MALFFLNGNKPEQSESVLIEAPRTMTNTITDSDGNEAYRAFMNKLAQCNVDQYVDLPMIAVMGDTSSGKSSLLSMISLVELPSNDKLTTRCPIRLQMRKSESKSATVKVIWKDSPEGFDYNFIPKEVTEANWDDLTGYISEAQTHIVEKQNKEVARDVVSVEMTGPHCENLTLIDLPGIVRSHGKDESASLSEDIQALMSDYLTNQRCVILAVLPANVDFHNSQIMAEALKVDPGTKRTIPVLTKPDLIDSGAESSVKELLLGEKTQHFEMGFHMVKGRGQEALNKKTTIEEGLTQEATFFYNTEPWRGVEDKSLFGTKNLRMKLGELQMKLIRLSFQNIVSEMKEKRESAFSSRQQLGEIPSEFIEKRALFRKVADDICRSIRPLIFGGHLIGKSKMFKRKPSAEFHVASKRFKDTLSKSRLANISKIAVGVDAIAFVNSNEVKDTVRYVKGNDVYFKSIRQNKLHILLSGRTADDVYEDGNHVKIVDNNNYAYIMKPVPMESVRRDPEWIRKLIEENRPYDLPIFINTEVFKGIVVDLIDEDWRLPAEELLTYTAGLLETATCKYIKSIREIESLVQFREFLLFKSTELVGTLMKESKVQVSQFIDREQVPYSQNHYLFENLSNLRSQRLMKELLSLIGTGGQDKTMEKGAVVSAVNLVFERNQARSMDDHMAEEMQHALNAYGKVAEKRFIDTVPMICIEVMEKYDRRLNDILSNDVIDSEIDRLVVAPPEQQRAMEKYDKEIATLDAGIAALKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JG67</accession>
    <name>A0AAD2JG67_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CYCCA115_LOCUS10711</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JG67"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:intracellular calcium ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Sodium/potassium/calcium exchanger 2 isoform 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="EF_hand_dom"/>
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        <property type="entry name" value="K/Na/Ca-exchanger"/>
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        <property type="entry name" value="NaCa_Exmemb"/>
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        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
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        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF73">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
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    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="115"/>
            <end position="135"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="695"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="766"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="795"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="492"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="318"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022568"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAJ1946569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="820" mass="90519" checksum="B7CA89D2E9455A9A" modified="2024-05-29" version="1">MASSLTEEELPITTTRRMDKRTARRIKRKKTYVKYAIKAGLLVAVSLGFLIYYAATSPSSSTTAIEEASASSFNTLNTSPIAYVESPILLHRRLQEVGEIVDVECGQLEKADPEWFAAIYFLGVLYTFIAIAIVCDELFVPALEEIASEDHMNLSMDVAGATLMAAGGSAPELFTSIFGTFVQESEVGIGTVVGSAVFNVLFVIAMCALLTKETLNLTWWPLFRDSFCYSVGLIMLGLFVGVISPAKIELWEAIVLFCLYICYVIIMYFNKRIYGILTGNRGVPAPGSEEAIHAAEENGETAMVESAENGIATAQENHTNNGEEKHDPAEEGSGFLNKHSDNQSHSDSSQLIVGDDGTKHAMHSNRSHKSHHSTGSTPSRRSMRRGPSLHSLDSGSVDLLAVIHQAGDGGSMKSIHEDESLTDLTPWPGTFRSGVLKILRNPESWKDTAGIGLVAVMAGDVHHVFKQVDVDDSGHIDKEELAQLFAKLECKIPAEELDMVMEELDENKDGQIDEEDFVKWYVHSEKRISMRTKLVFDFFDTDNSGKITRPNLKKLLKTVEPTVTDEDVDQAMAAMYMTGSKDEISFEEFSNWYVHSMIYQKRTKRIEEDEGILMDSIYPPEIEDGSSCGTIIMTYIKYIVVLPIVVILAFTVPDVRKPGSAKYCYISFLLSIGWIGVFSYYMVDWAEVIGHTIGIPSVIMGLTLLAAGTSVPDLLTSVIVARMGEGDMALSSSIGSNIFDILVGLPIPWIAYTALYEPITIGSKNVWVYIFTLLGMLVFVVVTTHLQGWKLTKTLAFLMLMFYFGFLALAILLELPFPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHT4</accession>
    <name>A0AAD2JHT4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS13540</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="12">
        <location>
            <begin position="154"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PARP-type" evidence="12">
        <location>
            <begin position="317"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="897"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="1138"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="1251"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="203"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="643"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="816"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1952412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1426" mass="158822" checksum="B544A9D908BF96B9" modified="2024-05-29" version="1">MSHSFKEGDVVYVNLEEHEFLSEKATKLIVEKESGVVLKTNCAYENDSGEEFDDGIMVKMKISNTKGIYPPSCVSNFVSSPISDSSKRRSTRGSLVSPSPDKEQCHDSSSKVEEKKQPKKRSRKEEEHEKPTKKSKYFPSGDDGHSSNENSLKFRVQKSPNSAAKCKHCKAAIKKGALRVQPFDSKRGWYLPNCLSSEFPGMSFSSAETADFEGHDDLSEEDQKILTDELNGVTAVVSSNSDNNNDGDDEEEEKEEEDDPPLSALKAKKKPAKKPAKKTTSKKGKKSNNNNNNAPAARSNIIAAPESDSDDDKDMPYRVEYAATGRATCKGCDERITKGVMRIANKPLFRGKPGFVVYRHLHCTVFSENIEQISDVGGWRRLNDEDREVLKARVEESKELVQKENEELRPDELVQATFQGETRGPPPGLTATLLPFQVEGHSWMYHQEVAIPELRGGIMADEMGMGKTLQTIATILDNRPKLQHATPGAKHPPSAPDIDARKTEEALWKDAQTSWEHEMEMCNVPKRILVNSKKKGAAPLGVRAGTLVICPVIALFQWKTEIEKFTDGKTLTVGIYHGPKRASENPRELLCKYDVVLTTYQVIESDFRKMVSPNKVKCPNCGGSYKIDKLRVHLKYFCGESAQRTEAQSRQRRTADRHEGNQQRPRGSGGGGGGKKKKMFSKKAHDLQTVKRKGSSNVRVKRSAAYDSDSELSVPDDLEISAARPSRSAAKNAKKRLSASAKQTIDSGESSDDDSDAFQTGTSSSSESEDEESVTPVKTTKRKVIATPKESYDSSFESEDDGAIARARSKQAAAMRRAKASGKGRKRKLDDKVKGKAKKGKVGKKPRGKMTKGKKKKFDDSSDSSSSDEDTSDEEVNDDPLAGIDIDKLMEEAIAGAKPSVLHTMSWWRVVLDEAHFIKSRSSQTAAASFSLTSIHRWCLSGTPLQNRVGELYSLIRFLRIDPMAHYFCRKEGCDCKSIHYRMMNGRCQDCGCSSIQHFSYFNKHVLNPIQRAGYQGDGRRAMMKLKNEVLDQCLIRRTKESRAEDMNLPPRVVNIKTIRLHPIEEDFYNGLYTETKNSFNDYIHEGTLLNNYAHIFDLLTKMRQAVDHPYLIVHSKKYAERNLQSRAPAIANGSVNCELCNEPPTSRVVSSCCGAGFCRECVVDFMSASLDDNNTNHDSSNCPSCREPFTIDLNQENADIEDDGTLTISPSKTTTGSPFDLMPSLKEMTHVSSGSILRRINLAEFATSTKIEALVQELVEMRQSRPGSKALVFSQFVNMLDLIRWRLHSDPCLADLGLGVRIIHGGMNVHARDQALKDFKGDNSVRVLLMSLKAGGVALNLTVANEAYLMDPWWNPAAEMQAIDRTHRLGQHRAIRAVRFIAEGTVEERVLQLQEKKRLVFDGTVGRDAASLKMLTVDDMKALFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHU4</accession>
    <name>A0AAD2JHU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="134"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="508" mass="57637" checksum="5BBD199889EC737A" modified="2024-05-29" version="1">MGKITIFSQDDCRHCKRVKAALYTRGIQFQEINLTKYPEKRNDMLSLSNRLTVPQVFVNYNHIGGADATMNLLAFWDESGQLAYLNEPDPSDPRLDVPTYPPKEETKPAPDRSTQTMIEIPGSEEKKGVLEMMEAMKFILPAADLKYGVKKYRNAFTGAQAVKVFQKCYQLKSPEEAVAFGVLLQSHRILDHVVGEHTFQDTEDYFYRLTCYQTPNILNSYRVWNEAVDPDPIRLVKGLTATLNKILSQYTSDKTGKVDYKRAGLDRSMTAFEEASCELQAVNLREMSKDTKMAFCINLYNLMIKYAFVKVGIPSSNVDRVAFFTKVQFYIGSDLFSFQDLENGILRGNRKAPYSLTPQLGSDDPRLLLSMDNVDCRIHFALNCGATSCPPVKNFTKEGIHEELRIVSQAFCEGAEQVKIDIGKNTVHLSKIFSWYFEDFGSSNMELLLMVSGFLRDEKKESLQSLFEASSSVKIKYNNYDWSTDASDSLVFSAGNVKANPFRSLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIU6</accession>
    <name>A0AAD2JIU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS14605</name>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000902">
        <property type="protein sequence ID" value="CAJ1940534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1954007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="265"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1940534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1954007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="607" mass="67996" checksum="9C985BD522927019" modified="2024-05-29" version="1">MRRHYHNVPGLLPILSHRTTRIACSTLKYVALGEERQQELTEMVARGLVPVFFGGDDGRMDGTDNLRNMSLSKNKTITAEKALRRVLREYQKEVTQWMDSGSPNAAEERRQTRKFLSDLLLGTSIMRIRHYHTLIAVLDKQENLRQDDEASIVPTYGLSLRDLGSINGVDISTYKYSLVRTSKTHPISLVDDDAKKLDLSRVMAHIHLQYLQEQGQDSSTMELILSDFLTVVKDPALGISVRYSLPLFFVKLLIDQYGLDLTEQMAKTFNAPGPITIRRNAIRCRSDSELQSLLSNRHGIRSAPIVPAQWNYHRNGTDALNNTAYIQLVTDDSWSPSKSSIWSLSSWKDGYFEVQDAGSQFIVQSIESTFDNNGEFVAVDYCAGNGGKALALASHIVMQHQHVENKNGESSLTGSPVTATIIAHDIVSDRLKQLEGSLSRIGLQEAGSTVKILTTTNLTACVNGQGYPESFADVVLVDAPCSSTGVLRRRPSQRFQLNEDEIRNRFPELQLSILQEASKRVKVGGTLVYATCSICSSENEQVVESFEDSSSNKGDGMLWKPLLYAPNQNQEEQEQSNRKDFRHCSNLLPIRIDSSDGFFVARWTRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJF4</accession>
    <name>A0AAD2JJF4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJF4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="598" mass="68526" checksum="106870DAC9634369" modified="2024-05-29" version="1">MPPRTPPTTKPKSQLNNQGASSLSRYAIVLILGVFFGRQWTLFSVDPHGSMSATAFEEEHAHMYNLPRLQDPSSTTTIRELEASSAPNIPARTSSAAPAVPTPKDDESTDEKKPIIAQPKDAESTDESSDDNDGADETKNKQKDESSGDENDKVDETIEQQSSKLQDEDESNEKQEASAISLETMAPQLTTNSAIDTTPQMPYNSSGLEATVDISTFQAEMDRRLPLWQKEAAKEDGWQDPPSVNVYDKVVLATKVHYAGRQSLNQMICLQKAAYNYRRNYPWVIFHTIPVTAEQVAEARAVAYPGTVTFVQDSPPLEEVVGNFSKEEQEYLIERCQCCHPKDKENCCKDRKKKIDWGFWCYEQKTGWVTLSYAWQAVFRSYNIWTHPALADYKYMVWIDDDAIPTKPWLKDPLKPMVEEDLVIFYDNFPAGFCKSGGIIEKMQLAYNKTYCYIHRVHVFKGNQTGKFVVRPCKKNKKGNYVLDKFGLVHGMMHITNMDIYRKPVHMEFQRLLTQHNTHPFSREWDDQIAVTVPAAFENPDKAWDMRMHGYNMSIHHNGKLDGKQKAKKWKYTTWWKYYKDEFPVAREMCDHLVKFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJX2</accession>
    <name>A0AAD2JJX2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJX2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042163019" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1955261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="248" mass="28144" checksum="8021A8935D80AEF3" modified="2024-05-29" version="1">MKVLSASLLLPLLLCTPSTIFAQQYDDDYQEYQDYGGDYGQDTLYHDYAERQENKGVGNTGGAGIGKLIVTGAATWLLGAKYHSGKVAKKLKRKHQGEQKKLYSQYYNDVYKLSEQNKQLQRQVEELTDLVKSTEAKAELEALQRDYDEFKQPDIDGDDRISRAEFNMYVKDYLSSYPGLSEADYPKFEDFDHDGDGFVSFQEYSQQMALQAQQAELEQMYSAEKQQKAQALNDMYKSATGGGGGLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK69</accession>
    <name>A0AAD2JK69_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001940">
        <property type="protein sequence ID" value="CAJ1957379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK69"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="18646" checksum="22D9AAC233EF3BC1" modified="2024-05-29" version="1">MDFLAPEKQQQEDQVPSRNREKARRLSIKPNDLTSMEVKCRTGFRDFPSLLSYAIVVCGGDLDRLFKTCSKLTWLEEWLFYFEFKYSFTTGGRWQDYEKMYKTSQKPLGKILLKKLSLELGTRDQWPMYASYEEDATFRDRKWDEYFNPATGEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLL5</accession>
    <name>A0AAD2JLL5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="112"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="502" mass="56671" checksum="99F86E0208C7C946" modified="2024-05-29" version="1">MSMSQGRGSSENSNSKGRSTGGRGSQKGPGRGGRGRGRGGRGRGGRGRGRGGRSQNKNNRSGRNHQENDNRQNVSVASRSYTIEPKESTERMDTSKNVSNQDEALMGAYQYCPREECDERQELKQVHELEATLETCSLPQAQRKLDPCLAVSKFKRSAAGTSHTVKPAQVLERTLSHLQRICARHQASPEHPPINNLLDWAEFLVDRLRAIQADATRLSSSNAGVSRDWHVQLVRMLIWIRYWTYSLDGDSSWLQRTINTMIGTAMESYWGQGQGLEGLSDADEKLHERMDDEMLCWSALLHVSQQQERQVGKRIGQADDLSCNSILLDFSKLSTTRKIAHHSLWSQVLILSSHLVRYEYYAAWKKMDNITAGLASQPMSILFKCCIEPNLSLWRYRTIQHYNKSFAKEEQITSVPRLLSIDPTEWNLDHARDFGLPVEQKDDGEIALVFKKAPLKDDAPRTNNAGSRVRDHRFTFGKCFDLNEKMSISSVHIDQMLKGGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMI9</accession>
    <name>A0AAD2JMI9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMI9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053202">
        <property type="entry name" value="EGF_Rcpt_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009:SF2">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="171"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="381" mass="42793" checksum="44752D4AE1D6DE0B" modified="2024-05-29" version="1">MIRSRKRRRRSNRCFACGEGCSMQGMLVLIVVVMFFLVAYSANSASDVEFDVARSLSTINDTTDTSKYHESSSSNPAKTTTKNTNAVTLKSQERPSFLRDKAAGFHAIHVYHGPEDSINSLPNNSEGMVYKQYGRGSQVDQDRIVAALALALASQVAAAAEEEPSFYFVDLAANDPIQLSNTLLLEKKGWHGLCVEPNPMYWYRLAHRQCDVAAAFVGSRQDQNKVTVSLTNKEFGGIVGDGMDNKDHSKVETEQRYTISLKSIFDDFGVPKSIDYLSLDVEGAEELIMRDFPYESYTIHFLTVERPKPELQTILKSNGYQFVMMLIYWGETLWVHESVAKQMGVDKIQEVAKANSDYVDKTPKKGQHLFTIDTGEYKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JML3</accession>
    <name>A0AAD2JML3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JML3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="116578" checksum="A6F8AF3BD9039864" modified="2024-05-29" version="1">MAALVHENKDNDSDSFSSGSDDEFLTVRTDGGNVDREALIRKKLLENFYGATPTAGRNDKGGESSDDGFSSDDDDDLAEDPRSSQDLDSPHFNADQHKAHHVLTQNVHNLLEVEESLACQVRTLDSSMQTLVYENYSRFIEATDAIKNISIHVQAHSSGLTELQDKMNTVSKDSLQIEQTVGSLRDQVVEKIRVKRLLQRLDALLKLPSTLHSHMSLHKYRWATKSYVSALAILHKHSEGFDSLKKIETECHGIMETLVATVQHKLIHWSGASFLDDDDESDEEEGDGKEASQKKKEMEIDADDIPDGPTTILDIFECAGTPILIWQSKNAQQLTPRLSAEKCQEYALKACLRLLERVLDSHQIQLQERMFTSKTKQEGEEAEGLDWLIPTNILDMILEAATLYSMTFLQDQDGHPQPDEALSVFVSNAFSTFLTHVRGALLEQALQASPSTMEHDDLGVLATGETDSLDDRVLLEGKDEEAYEQISSALTLLLQGVKQLSEGLELQDVAVGNDLASSLVDQAVSLTETMVRKRVDQKFISLRQRVIEDCLAPMARSTFSQAQDGKQSGQQDQSLLEVVQLASVALSDSLQLVDDTVRSILATPEISEGTMVLDGTDRTDNPLSPSSNNDDNGPSADGAMMLEAVEHSSKRFALWLAASMEVMSGCEASHSSKQKLFDIPDSTKIPKIRKMDTDSASYDTGSMDESTQGDDLMDTPEPWTEDSSDPVVERALWNLVEEISKYPKNGNKSSAYMTLAISEICRVAERSVMENISQSISAHSGQRGKGRKNKSFQVGSTFDSTTNTRGLPANPIAARFRLAASRILNLFAMDRGAVAADLLCDANMIEKCSKEEGEVSESPRAGAWQVLEIVKETCLDCADLFGGSARAGPVPENLDDEYISLTMSHKKSGLAIDVERMFAEKIVVYPHPKDMTDFSRNAVVVLILKVALKALAENSRCVKFSLSGYRQLMVDMEFIKFLIPHYVKDEFFGDGSNSISGLEALLREASSVARQRCFAVGELGDYQEEVNVARGAVRVFMSNSDRLVKKFTIQDEGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPB2</accession>
    <name>A0AAD2JPB2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS23688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPB2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1969398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="287" mass="32139" checksum="6C071857F1CE3681" modified="2024-05-29" version="1">MDLIIDGWFHERGVLWPGQAMSLKVKKVLDHHRSDFQDILVFESESHGNVLVLDGVIQVTERDEHAYQEMIAHLPLYAHPNPKKVLVIGGGDGGVLREVAKHPGVEEIIECEIDEGVINVSKKYLPSLAKGYDDPRVSVKIMDGAKFMDENQDSFDVIITDSSDPVGPASVLFETPFYNAMYKSLREGGIVCTQGECMWLHLDLIRPLIDSIGKTYSTVEYAYTTIPTYPSGQIGFIIATKGRGECKKPERQPSEEVQDGFQYYSTELHEASFVLPAFARRSIFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPI7</accession>
    <name>A0AAD2JPI7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPI7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="424"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="518" mass="59808" checksum="00F73B1493B6FDF5" modified="2024-05-29" version="1">MTMASSLPSNHCTRQACLPFSNYNYQAKDNNMSKLEMKETEAFLASEMNRLSVQERSNALDDLHCVGEEVQETPDMIQKALADFDQAVRKEQNPFYEMAMNQNRAYVEDPTFRLKFLRAKLFNAREAVRKMMSLLECKAKYFGHGKVGREITLDDLSEEDKQLMLSGIYHIQDGRDRNGRLILHFFGKMLSRCKADNLIRIGYYIMYNILSSLPDVQRKGIVVIYNDTTLPEETFSMPGFHFIKELLAFYDSKAVRFSGIHYCLQTKGQNLELSNVIINLFLKGAPQETRVRTRIHYGSIIELQYQLQSYGIPLSTLPFGVQGNIRIDILNVWLHRHLEQTNQRICFLESEASHGWSQNMEVESDFGNHEQLLHSDANTDDVREALVLDLWHICDPMWASTEEDPGDTTHINSVPGSIEPTEMDVLFGKGYRLQLHPGNVFFREFLEQHRDEYESTPRQNRRAMAVELAQSLRNNGARFLQKAESGEWVESDNSQAEKKVSQFFRELRKKRSKAAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPV6</accession>
    <name>A0AAD2JPV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS24333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002493">
        <property type="protein sequence ID" value="CAJ1970313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="10">
        <location>
            <begin position="209"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1970313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="388" mass="43380" checksum="46C4C4C635C15860" modified="2024-05-29" version="1">MASGIRFLHSSQPPVIHGDLKSQNILIDSKFRAKLSDFGFSNRKPDKATGTPLWMAPELLSGQSLNTPKSDMYAVGIIMYEIVARKEPYYDATESNQDLLKGIVDRKKNKRPRIPSYCPIKVKKLIKFLWHGDPSLRPTASELDNRLQEMDFKAFEACAHASGSHSMQEHTKSQGDNDEHFLYQAFPRHVAEVLKSGAKVEPESHDIVTIFFSDIVGFTTIAGQFEPLKVSQLLDRLYLKFDDLSRKHELFKIETIGDAYMCAGNLATDQYLDHVKRVALFAMDAIKAASTTLVDEDDPSHGFINIRVGFHSGPVVSNVVGNLNPRYGVFGDTVNVASRMESNSEKGRIHCSKASAKLLMTQAPEIKVRLRGETEIKGKGKMTTYWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PTY6</accession>
    <name>A0AAD2PTY6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PTY6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="220" mass="25591" checksum="426F6A263C63FACB" modified="2024-05-29" version="1">MEIYLSYSEPNLETAVRLKEDIESYTSLSVSLESEDWEEVEDCEFEAQIHQADVLLNLTAETSNITAWLIDEEKRLYRTKEPPMEVSLPQTVDISYSSYEDGFAVLLGLISRHMDRRFGPLQMQHESEEEYESSVELESTRESMRCLASTAKVDSVRPLGSDSQRNAKHEMCPREIFSKSKMESERTLDRDEALKARRKQRSSRKNRLREARSHRTVPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PTY7</accession>
    <name>A0AAD2PTY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WDHD1/CFT4 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001715">
        <property type="protein sequence ID" value="CAJ1946833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PTY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="2">
        <location>
            <begin position="480"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="965" mass="106648" checksum="21F640D1BAF7A4E6" modified="2024-05-29" version="1">MMFMQANFSLGLDDVDGSEEPRRFASLPCKTLLAYGGDDGTVTCLDEKDNTFHAVQRFDDCVRAVAVSEDGKRVAVGFDSGEIEIFHYDTFELEKASRHPFAEINEKANDDDLLSQGFSDCHKASVGGPQFDAPIRDLQFLRGTSPTFWLIVAHESGMSIVDVTTIDSMSSRVLERESRDAHGQCGIRGVCQRPDSSQIVSLSMDGKLCLWNTDLVDHKMPSFKLAQFETNRCIAKQDAGEIHGADACERSYRPVLHGDVLATPGRLTPLVHYLGKESRIMEVKDCDTNRHIEPVVSLVFLSSDFMISSGRDCRMVLWKCDFDKFALSSVASITSTSVVTAFHAREMGSIYAACTKGTCIQLNVEQRSVESKLPKDSDSPRNHISETLACSNELKKKSSSEHGFCVHEGAHSEYVDDEASVDSPSRNGTKSDTPTGFSQGEQKKGSNEELGSEDESEAEEINAPNNLLSQLVREETPQPPFSVSSTPLDLARRYLCWNHIGSVTILNGTEGASHRSTVDISFTDSAYKRPVSFTDNTGFIVGSLGEDGAIFASDLQKDDDDGLDERNLRGLQISEQTLQAVKRSQRKRIEQNAKPTGSSIFFYRFETLGALRDKDWFLNLPTGERVVGSACGSGWAAVVTSRRFLRLFSSGGNQGQILWLNGDPVTVAGRSRFLIVFCHRSLPLVDKTQQLDYVLWDIASFTVISQGPASCVGKGAALSWAGFSSDCAPMAMDSDGIMSMLTPCSNDGRNWQWIPVLDTLGLRKSSEDNFWPITVQDGRLVCVPLKGSSTYPDAARRPITATLGLRMPFATSSPAKFTMLEELSIRSNLALSQKRALEIDEDDEEYVGLCAQVDKVTLKLFVGMMDEGKVERALDLIDRLHLPKSYEIAARMAEHNRKVADLIEDAKHKNFPQEEDDTMGRLVCNSGSPEPSNEDPHFVTPVSNQPLQKRNKAYGDRTFKKPRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU24</accession>
    <name>A0AAD2PU24_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11262</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16587</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23566</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS23570</name>
        <name evidence="5" type="ORF">CYCCA115_LOCUS23628</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1969168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1969284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1171" mass="131100" checksum="9951DF6AF6F7777B" modified="2024-05-29" version="1">MKFLTDAFASEHGTRGRTFWDQLTRLPHKDLTIHDQLINPRRGMRLDKTIHQSFGHPVTNTTTPVYQVTCPEDLEPEDQRMEELEQLFDKWNDPQLTTAQRLRNGETLSPGFALLVRKGEDGEPCHIMFISNPVLTKPDILEPNTCGAPAPLGEIVTNDLARQYVSDPTKQTHFLLGSMSGHTFASPLTGNRIDFAKALLPVLMTDGDAIGNKPFNRDAWKILFFPTMSACPVGFVWPASGGFDEFQNSIANRKKVFSGLLHLMKTRKPIIESWFTAVKDSPASFAVPVVDAMPLWYSFPTKEDLDNDQVLDKALLSPFQEQMDRFLRSHLMQIIYRSASLPTSPLGFKMRARVKMHNMRVSDSFPEALGTTLPAECQAFVNYLFPYEDEERSWDGRVSKWYKLLDLDPGSEVPESYLQYTPRPLPSSAQDPEGYVAQRLPLPSAAPAGLPVDDDMAEFIQAAKRHKPSLRQAPIRTPVPARGDLIVLTEDGHFEDGHGTNYEPPEDHAGTQSFADRQLPAVTPSPLQNRHMGVNHPNSNCFHDATGGNPFAGVMNGTNIPLQSPAQGMPPNGIHNSTWNSPFQQGPRVQIDPTPRGPSPFAGHNTGLPTPGLPTPMHHQQMFPASPGIPSPHMYTASHPNLSYPAGYGSAMYPMGYYPAHPGFTTNKPNLRSKYTPVRTASINSDMERICCPPELKAIGYWLLHPVPPTVGMVRTSLGDRMASDVLQFGLPTEIGRRCLEGFDYKNDGSVAANIVCTAIEYRTKYQFGTFSQVGELQCDLRSVMDSAFIKRSFDIATWWVDPDSAPPPGTSKRFSLLAFLPCISEDFSSDYLPSDGLSWQQMKEFAMVIYYHFALLGSTNPTSDNGDYNDELFCSSLFGHCLRHICQYVLNTNLGRRWAQTPAQCTAAYVRDLSELFHILKKFVDHRIGHDVENYGISDAWPTNDRNAVFMSVPSKTNSAGFMAQTESVVNVLHDYYTRIQRNWGAGRYTAPNECSWAMSSSPFFAPEKAAPSRLLDLPKPKTTERTRDDKENVPFRNTSPLFVWNHTVTPLGKKSPSEMLYPVVQRGTYPLIVDPHAKRTSGKNTLYPICLNSTFEGHCTCSKPGTCKTHKVGRYAGKTRLHIDLNDARWSAATYKEEDWKPIVDFIKKYHDHILPSKAFKKLTPSTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUR9</accession>
    <name>A0AAD2PUR9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042219329" evidence="2">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="210" mass="21070" checksum="362B4E9DB575F8BB" modified="2024-05-29" version="1">MKTTLYFLACALLLDGAAAQCSLCPGGSSAIGSLNAALLPGTNDATCGQKEALAAAASNANCSAVVATINAGIDYSAFCCGDVRADSNSCKFCDGSSVDVNQAFPSDFSNAVTTCGQAQTLTQYISANDSACTTILNIASESCCPAPTMPPTRVPTVTRPPTPFPTPDPTPGPTRRPTSAPAVPATQSGANQVSMATLVILGVSALILQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV03</accession>
    <name>A0AAD2PV03_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001817">
        <property type="protein sequence ID" value="CAJ1953087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV03"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="46" mass="5319" checksum="1C11B6EB43E2FC76" modified="2024-05-29" version="1" fragment="single">MSARTDFQHYLHGKKGGENVRRAESQEGQELTVAMELVRIKQNVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVY7</accession>
    <name>A0AAD2PVY7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="362" mass="41685" checksum="D70DE8A27ACE729B" modified="2024-05-29" version="1">MTSLTGAPLAKIVAVTSENQELKSKLTESRTQCENLEQELRFQTAKALEFQEMLALKSDGDVDALLAKFMEHSLTLAEQTLEIDQLKLKLRESEKEKIARDQEREAHIEMMASLNRYIRQQGIALQRLENPSSLTPKDYEYDEIDSEFDQLCNIHDHLKDVKLVIERKEAPVVIEDSQKVKKLNKDLKQVLAERAHLKRKVEAQNAAISILQERSKTRETSNLALVKDLKEKYESEKRGLQDTLRSLEAQIQTLRQNEEQSESEPSCLHGELIEIESQKYEENYEIYEPLLFLTDTKADCDVFEDDASEITASTFLNSESEQSTPASMSSLHQRKHVSLDDYMDFGTKFEAIADFSMQRFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWT9</accession>
    <name>A0AAD2PWT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS19880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWT9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="60"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1962845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="489" mass="53921" checksum="5F5817D8AACE53E1" modified="2024-05-29" version="1">MANSVQVEMNPNALENERQDEEDQREWKKYRRYPLDVDPDQGDKSKEIMLCDFSRPHMRAFHCSWFAFFVAFFIWFSIGPLLPEIRKSLRLTKEDIWNSNIANVAGTVIVRFILGPLCDKVGPRVLFTGVLCFAAIPTACTGLIQNSLGLILLRLFIGVAGGSFVMCQYWTSIMFTKEIVGSANALVGGWGNLGAGVTNLILGTALFPLFKEIFKSNDNPAEAAWRTVCIVPAIIAFGTGIMIYRISDDCPKGNYKELKEHGTMQEVNAVQSFCKGSFNFNTWVLFIQYACCFGVELTMNSAAALYFHDKFRLTTEDAGTIASLFGWMNLFARGLGGWASDVLNMKWGMRGRIFAQFAFLLLEGALVLFFAHSDSLIGAINVMVFFSIFVQAAEGSTYGIIPYVDEEATGSVTGIVGAGGNVGAVAFALAFRSESIDDRTAFVIMGGTIMFSALLSVFIIIKGHRGILCGKDDEENKRERGNPRSFGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWV6</accession>
    <name>A0AAD2PWV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GPI ethanolamine phosphate transferase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS19943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="657"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="749"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="864"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="897"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1962965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="102790" checksum="580EB2C272DC096E" modified="2024-05-29" version="1">MRILDWLIPILTIIGLYWFSASFFLAKRSLPHSASCDEAHSLLTEVLKLEPSEVSLILGEDYDNKDAAASGSLRDGCWLPRKVDSVVILVVDAMRFDFSQYSLPKSVGARIDKHQTPSSQLLQFVADPPTVTMQRLKGLTTGSLPTFADISGNMGGSTMDEDSWVQQLKNTDYKHRGLQYPSKLGFVGDDTWIDLFPVLFDESHPYPSFNTRDLDTVDNGCLKELPNLMKHVRRKNSHSLEDLELVVSHFLGVDHVGHTYGPFNEHMDAKYRQMDEAISTTLDLLDEEDQEEEIGSKSCHLALVFGDHGMTNDGNHGGGTDEEINAALFVHFSKGCHLDDMNRTMPLEKAAEIMGSTYVQDKFQSMNQIDLVPTISILLGLPIPYQNLGGIVPSLLAAHDIRETAAALALNAAQVWRYFTIYSQTANRLPNLPELEEQLKDAVSTYREALQHNEDGQDSNAFYTACGLFKLFLVEASELGHRVWTRFDTLGMTGGGLILAFVVLATLLPLLFLGKSFLKEQNQQICNSRGVLENILALTFVVFHCGMLSFSNSYIDAEQRIVMFMMTILGGVIFVRLNSTVAGGNSRLLPYVPVLLPILSRISEIFVSGHGLDPSIRLYAAHSQWLFLPSLALLFAIRTQVFEKIDRHHPVNTGGSIIGSSTLHAGIDCLSLVLLAFSWIEKRNPDPSRNGYWSARGVIGLLIFSIVLSILNAFSTSSRDLQSDETSENTSLSCARTSVAKALSMISRLLIAIMLVTGPATSCTVLIACLQGWMLFNLAGATGFYQVSVPVQALLWRLVVRHVFFATNHGCAFNMLQYSAAFVATIEFDFVFAGSQLFMNTFGWEIVGISAVCLTTFFTRKPLWKWYCFYQILEGFLNCISVSILRRHLMVWATYAPRFIFSAIFLVLNSMGQLTYNFLVMTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY43</accession>
    <name>A0AAD2PY43_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002447">
        <property type="protein sequence ID" value="CAJ1970013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY43"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042233934" evidence="1">
        <location>
            <begin position="28"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="213" mass="23770" checksum="A736946FBD693701" modified="2024-05-29" version="1">MNPLSLRLTTAVLSVLLLAFHPQTVVGFANEKPTAKQAAFFSSSYRTSKLLQSSRVLPSEEISTSSTIVKAIHNLQERFTEYQHVRKQRKLGREASLLASYCSDKNSMVQGFVPVVKEFLHKPNKKLLQSHVMAHQQAQYDHLVHAYHEQALSKRVMKSSSSTTDAAIGPLSIGQCLVQTRKEAKDARLAAKYAAIESLEDRAFQICKDLGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE03</accession>
    <name>A0AAD2CE03_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1930973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE03"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="121"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="392" mass="44280" checksum="0B81A3B33D086258" modified="2024-05-29" version="1">MLNPKEAKRLLEHCLPALQQCRSSSSSASSSASSSAPSSKNNNTNSNSNSKNKNKNNTQPQYDNKIQVENMCRLWGGMGYVYQIQVAVDHDRSSDDLVEFIMIVKQVSNNNNKRLSLGDQRKADSYECEANFYEHMAPILLQKGLEIPTPLHVERQNKGVTICMTKLHGDSSYLGQDETKAALQWLATLHAATWGSTADKAVDEFGLQPQGSYWYLETRPDEHASIRSKGWEGRLKRAATAIDERLKRDPMQCCVHGDAKGANMLFRQHEGELVVGMYDFQYCGKAPPTKDLAYFLCVAADDNDSSYLEYYHEQLLERLDHESSSSLYRPTLEELQDSLDLAYCDWARFMAGWGYWGTDISKHVIKVLDRLDGGKDLGTEDAYREAVLREYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEN1</accession>
    <name>A0AAD2CEN1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="144" mass="16171" checksum="03BD02C637E6DC17" modified="2024-05-29" version="1">MCTKTRRIAKSKPDSCTEKNLDAPRTSALNSFLNDLIREKRAESEGTQFRIMILPDDAHGSEGGLLRRRSSRIGRYNSDPLPSLKKRGGGRRSVLDVSDHTKRLSRWLSVDPASSQSKQILSNCMVRQPMRIPSSRRINAACSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEN3</accession>
    <name>A0AAD2CEN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1912888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEN3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="623"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1912888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="742" mass="82586" checksum="26E91B463785707B" modified="2024-05-29" version="1">MMDVDNTVATNATTNVTLTSEPKQPQHVQQQQQQQQQQQQQQQQQNSIEPVAPKQQSQPQNGSLKPPPQPSAQLKQPPPSNQQQQQQQQHECEPMQLKGPIHVLMTMPSSKSSSSSSSRTSAARFGGGRIMDNGKPRSKPTKRERMQQLLLDPVLQGDYVTKRLKAYQRCMPKAGEVGKDEKPKTPSPQQPKAKSKQGKLALNNQSKCKSPTSVWDGVSQVERELVNCCESILSSSSSSSSSSYLEGYSASSDAHDDDDDDDDEGGLQKSAQDGALQIQKEVQFVGILARDCHTLSAKSLALSILERTLQLHLLENVDDDDEEEDDDDEMEEEDATTDSKAAKGGTANAENEETEALESPRSKRASTRNDESASEQPQKKQKLEDIEPEPEAGKVASMPTQDEEDEEEEEEEEEEDDGKPERLEGFLAAGGLKILNRWLIDACTEEMELPPKQPANGKGQQAAPKPKPPATRPLILPMLRFLEHIPFDKKVVIDAKINKQIRKLGKQVTAIRKAREQNTHEPVDLQNWSLDPTVDAKDALDDVHQAIKDLKSSWEQMAKHDPSEFDDPFESLKAKMKERLDALVQYEVGEAPKPDWFDDTETGKGNAKKPPKSKTSSTKELAAKERLAERENLKQQLHAAQTEHRERLAKLREKFLKRGGDTEVASVPSTNGKKKKNGKKVVWKDGMRSQISRNREELEQVFVFEKQSPPAQDLLEITNGPVEDGPIADALMDDVEAALEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF85</accession>
    <name>A0AAD2CF85_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000225">
        <property type="protein sequence ID" value="CAJ1932888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF85"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="512" mass="56773" checksum="6F4677A9FBD8F72C" modified="2024-05-29" version="1">MVITNAQNTAFFTHDDQMAIPPGIFDPHLNQQGITTIDSLKEFNDAMLDDIHKHITRHGPPNSVFSALSLSRLKTAASAVQFYLATGRALTAACMRWTNTLIMYQEKREALKIAQEREDPKVPCVSKALPIMKWLAAFRSVIHESYGVRGFPLGYVLREDADVPAEPPLAPDRPYSIEHGSLVAEFTARASHTHPRFHQDNARVFAKLEEALRGTTYASSLTPFEQTRDGRGAFFAIVAQYLGKEKWSKEIEKNTDFITVQKWKGNGTFPLERFIGGHRNAHQALLTASQHVEYQIPNEHTRIGYLLRALHTTDPGLHATIANIEGNEDPNGPRYSFEECARLLQLADPVAKKNKRSHAQISDTTVTIDESANQTIEIASLRSGIGTTGVHLRFYKKKEFDKLPAEQRAELKAWRLTPEGKAAIARDRAAKAKAHGGNSSPKKEGKISAAAFEKELKQRVKQYTDEEDKKKGLHDTLVSALKTANASSHAPAPSASADVNAIVLAKILGKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF87</accession>
    <name>A0AAD2CF87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3107</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000227">
        <property type="protein sequence ID" value="CAJ1932980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000347">
        <property type="protein sequence ID" value="CAJ1934619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="560" mass="63627" checksum="810B968371055DC2" modified="2024-05-29" version="1">MSAMEKESHENSATEEQKSVKIKHEPGAKGPGPIVKTEKGHGLEATSMEIDMKVKNEPNAFEERKPKAKKILTDSLLGTGAKKPPLKAKSTLAKVKKEKARLPKTKKTGRCKCKGDCRFAELFKKVMAKQSEKMGPHVHGQYHNSNSQRRKRFYNYCSREDKSLNEKKMDPRHSQFDSKMELPCTPKLAAIRSVTWSHNFTMARSNRNVTSAKPGSCPMNKKLRNAVLDELITTHEQNPNKRRGDIARIVEASQEEYPYVTRDNFNNRWRALKKQRKEAAAATNSTENSAGSSEGSVLANAAEGDLNSAEKAGRKKGSTDAAKLERTQQEMEALHWVTMKCKESKDRNPKKMKSGTIDHLITSARSKFKLPPMWNPSKETIRTRLKKKIHVVNPKRGPKSPVPEAVERTVVEIACESNRCGRPLDTSEIIDLANDLIKGQPIEKDIIDWQIRFCPTIRKRFKETKERPTSANLGPGWYQGFRQRNPEIATAKAINHDERRASWCKYGNMSDMFGMIYKRLKEAGHAKELPTPQWQDLHGNVVSEKEAYGHRVEYYLTHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH42</accession>
    <name>A0AAD2CH42_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1932621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="41254" checksum="64B7E53D120818B0" modified="2024-05-29" version="1">MSSFDAQFIDNASCCGLIYKQESASEINQEDVDVILAQGMQHLSFDELQREQEDLHGVGEMIDKENHQETISLLQRFDDQLQRRKKHTVYESAEVMMNRDHVTSSELRLQFLHANRWNPETAADQFLSFLEMKKQLFGMDKVVKDLTLNDLDEDDKENLLGGSLQILPCTDRSGRRIILELPGLRCFKNLRNELRARFYMLANLCSHLKRGVVWISYATGQYRDNMNGKGFVEMTRMAMSIPMHCAGIHLCTDDPSEAVICKAAMALTSAELKAKTRIHYGSHTECQYLLNTFGIPRVALPFTTMTNDPILEDHMTWYKQCLKEGQNPDSAKTSFVGRLEPNPRDVLFARRKFSGKVTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH68</accession>
    <name>A0AAD2CH68_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000347">
        <property type="protein sequence ID" value="CAJ1934614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH68"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041969789" description="Helicase-associated domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="70"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="225"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="290"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="353"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="423"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="496"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="568"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="639"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="709" mass="86022" checksum="E2BFB1212543C1C4" modified="2024-05-29" version="1">MMNLLLLIMASSILLLFQLGLTTAFQSSLPLSLSSIHPQQAVCQWPSTASASAAVVEETELIERTKDPPDDWDEQFEKLQSFKEEHGHCNFPQNASMELQKQYPTLASFCHRQRIDYMNLRADRRRSRRMGLTTFDRNARCCRLKEIGFEFHTQRAKWYDHYYELLQYRSDNGHLRVTESENSRLYAWIFRQRQIANGEDCPNRSEAHVKLLENIGFTWKSERKDALWMEKYQELVDSRNKHGHLLVDYKSKLYEWISVQRKRSNSLTDERKRLLDEIEFPWKGERFFDRWLAKYNELEEFHKIHGHCQPCYVQNLPLYDWVRTQRVHRDNGVLSTSQIQLLDDINFAWERKVTWRTMFAELVEYYNLHEHLQVNQGDDPELYDWMALQRKHYHDGIRKKKMSDISIEKLEEINFCWSQDWKERVWHEMYTEAVEFYKEHSHVRVKKKDNPSLYNWIATQGKRYKKTKGHKPLSEEELELLEQIDFVFFNNQPRMSWNVRYAELERYREENDGCFPDHRDDPKLNLWIRQQRKRLRSSYGYIPLSDEQKSMLESIDFPILPKGHDLRVWYEMYDELVEFWKRHGHFLVTQYEPENRKLLKWVDYQRSKYNGCGCVRALTNSEKYLLERIGFPWTSGFKEMEWQTTYAELVRFQQKHGHLQVTKREDRELYNWIKYQRDRYANKGPTKVPTHQIEQLNKIGFRWVTENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH87</accession>
    <name>A0AAD2CH87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1920730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="124"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1920730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="316" mass="35906" checksum="FB4C29C688C30768" modified="2024-05-29" version="1">MSGNKGFMDDQLAAMLLQEQKFYRCSDYLGSCSSSTEHPVPITVCPLQILNEMANLVTDTQLVRIDSSSNFSKSDSKSEASPTTVVHDMYESPHHSRPPLSKQQSQRDKFELSLIGAWRSQMFDWICQVVRFSQLNKGVVEVSFNILDRFLVSKVQHDNISREEFRLYCLASLHIAFKTSASAGRLSMKQSLSMSGGFYQVEEIQAAELEILQNLQWHVNPPTIMAFCDLYLKLHETQLSKKVYSACEYMAEVAIADEFFISKPCSSIALAITLLVTRKEGIRFAWAQKLLQELRGRVFVEGDEFESILQQLECLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHI1</accession>
    <name>A0AAD2CHI1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000119">
        <property type="protein sequence ID" value="CAJ1931043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="193" mass="22062" checksum="0D4D8AF510E452B5" modified="2024-05-29" version="1">MFYLPKNDDCLPPIHYVLQALQDHPGAWEHFCRDCNVHMVAKLRNKNNPMQPLNCNRMGGLATREWPCLVGFRARQWTGQILETWVKKVAQKLQSVAHIKCYYPLPLEYAGDITLPNIQVLSCSVTVQDILEALEQRIFPDMTLANILEQQDMTIYFGNKSLILARSHVTAGRGDAAANGFYKPHIAHNNFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIM6</accession>
    <name>A0AAD2CIM6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042261511" evidence="1">
        <location>
            <begin position="22"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="411" mass="46309" checksum="6326B88893C1E3B5" modified="2024-05-29" version="1">MSTRYWRFCILHLCLFHACSLHLESTIPKSLDESWSSASSTSLYLSREPLAAVTDRSITSSTTPSGISQSLSLYSLQWTPDDRISIPVRSTWRWKDAVLGDGRDFFVPKPKTIQKLQSIFMDNIPGLEECSVLSNCARFAVLCKWNDTDVPTVAERDLRCEALSFCLLHQVDYNDKTAKKHLATLTQSLDLPKLLSTELPSTVEVDSAVQELSRHWDCIHDISAIMLHLCKVSAGTSERPRRPDRQVIFRPYSSRDAHILLQLKRTKAAVSSRSGVLNDLLELAIRAGKAARNEMIVPALKELKPYGSSKDPPLDLSIEVQEKVIEDAIEPLIQECLEKWKASTNKDSITTLRQAAESLSTSDEELAIIRKLLHQPTIELRRSPETVDVQQILDDIDYKLQSLRKSKASLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIN9</accession>
    <name>A0AAD2CIN9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIN9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1930218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="180" mass="20738" checksum="E3C26DA01D4F8641" modified="2024-05-29" version="1">MGCHRIPFEVKGAPIRSSTYEIDMAHRIQTEGVPLREQYTTPMEATLLQNKYDNHPAVGANLAAVEKKIAKEKWNSYHIHYLRFVYEFLPGLVINPIQWVFDKGKGRICIDCSNGPNLLGSINLYIPSLKDAIPGEEDECPAVYYQYAFDRFLRQILRMRITRPNDPIMVYADDIEAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIR1</accession>
    <name>A0AAD2CIR1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIR1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="205" mass="22993" checksum="1CA61072DE0B21ED" modified="2024-05-29" version="1">MEKGNQQAEVPMHEQAKQGGKCCGGCCDYRRAVIVLCIISLVFSIIGIVNPALSQAFQAEEYPELEQIVKDHNTSLLIIGIVHIVMTVIALVGAIIFNFYLVALYVLWSILNLIISIVLQQQMVGDLLDWVDAQTDDAAWGTTDQDQLETAFNTYMIINYVITALFTLLWVYPSVFLSVEIKKGIMTKETYPREEMSCCCVSNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ71</accession>
    <name>A0AAD2CJ71_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000370">
        <property type="protein sequence ID" value="CAJ1934739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="224" mass="24775" checksum="EF8A4068AF85983C" modified="2024-05-29" version="1">MKVDNGPGRNQIEALAQLRNNGIYVFLGVPNTTSVSQETDQNCGVFKSIYRENREKMVNDQNLMQKPTNLSLPVIGILIFGGTDPVTGENHFCSAFDEAFSKEKCLGAWAKVGAAPCTRKCLNSAKVCHQLGDDLDPMATMYKVIQQQNGQHGFTQQKPDKTAPEIEAFLFEYLKTVRQPSLGVPTAQVWSRRPHVFQSANSSQAKLGAQGLLEGLVSHKWKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK00</accession>
    <name>A0AAD2CK00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS4467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1935129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="41031" checksum="FA094B87597E1231" modified="2024-05-29" version="1">MKLPGEFAVHYETRNHWAVITQLHGSVYIYIWKYCVFNVLMMLLDFFVFDDLMAKHGIKITDKGHTISIFFVAFFCVTRANMALARFNTARSNLGGMLASIRALTDAVASHTMDDQTEAAKAWRNKLAYHSCLTLRVAMAACDFEDKQVMPWDVPEMDDETKTKIMRASQSKGIADQWGYAKRTPKEEAYRVPFVMAQILRMTLYEHKTALEGGELPVGFLLKFNSLIDGFVNSYNAQNKMFTTPMPFPMVQMARTMMFLWVYTLPFALSSDGSTILVHCVVVMLLTYAFMGLETVSLQLDDPFGNDENDFDNLGMAKTVFEDVIRSIDMVDGTEWALKVRASMKGDPAEDKFPSESTSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKC7</accession>
    <name>A0AAD2CKC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calmodulin-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKC7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041944249" description="Calmodulin-lysine N-methyltransferase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="34300" checksum="E51739FA03566DB2" modified="2024-05-29" version="1">MKLIQGISLVVVTSTMILSVDAFLSTFHDPSTTTNLLASSTTSTPESTTTTTTTTNTTTNTTTNTIQHVVDGVVCREMPLEVPIIGTVTVLEATAQSQEDLVDMALALPEESESGLLEAGDPYGAVLWPAAWAVARYILSEPKLTLENVNILELGTGTGLVSIALALGGAKHVLATDYEPLALKLTTYAAETFHPTIKEVLGTKLLDMCDYDDKLPQVDLVVAADIMYEPKTGIAMAHRAVEALKQGSRVIVGDSPGRPGRPAFLKALQELGVEGVEFVDTIGRTCTGPRHDLICGKGSTSVSETPKDLAVAIMDLNPEHLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL84</accession>
    <name>A0AAD2CL84_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000500">
        <property type="protein sequence ID" value="CAJ1935692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="412" mass="45219" checksum="71D738E85BCC4E6F" modified="2024-05-29" version="1" fragment="single">KLFATHDDSSEEEDDETQEGAGSLSGAFTKVTKRKVKKKKKSPLSDYLENHFLKDLSPAQRKLAEATDRKLQNDIDRHKAGPLFLMILPGEMEGSYIFVCRKKYGQLARNVLKGIVPFLIHHLCELTDTQTDRVFGKWIPKSEIQATRPKRLVWCTNTLRAIQASDQSTKVEEALEFLDDVIEDTTDVYQGQLSIDMDMANAKDIGDGQTVTGMLDEMQECEQQLEDAFVEIEARDNALAAKDQALAQQKAATAALQAQLEALQRQTAHHLAIASQPPAQNNEVSPGRSEFTTPPKKRKSKESATVKRSVDRSTAGLKQPTKSTRTSTSVHFQQPKQRSWKKSQAHVDTTQMEGDTTTAVSQDESLSSLTAASPGGVHPFFLPSPSSKSGTSGSTKLPSLVGRGAPRSTAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLH9</accession>
    <name>A0AAD2CLH9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000669">
        <property type="protein sequence ID" value="CAJ1938108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="102" mass="11752" checksum="AFAA316A6A7420AB" modified="2024-05-29" version="1">MKFSSLSNTFLLSPEAARETAAQTEEFEHFERIEDKRPESRTPRNSSVYPPTFERRTRLLHTGLPPASSEPPKSLRQETDQAILKPIKEIESSQKKMSHEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLT5</accession>
    <name>A0AAD2CLT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000569">
        <property type="protein sequence ID" value="CAJ1936865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLT5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041981622" description="Subtilisin" evidence="2">
        <location>
            <begin position="24"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37856" checksum="E452E7555E4E3686" modified="2024-05-29" version="1">MKRMDSFSASVILLLACVLKVGCETNAQPAKNNSTIPSETINTMLQRSMRDSYRRPDLPIFGEEDIKTRISNHNTRNRTRDDDVIRHDHQVPIQTATKKSSSKKSSSSATSSSRSSKKSSKREGTILFPTHRPTSLPTTTQPTMTPATALPTSSSVPTTSSMPTISPSEIHSPTDQPTRVIPTRDPTPGPTPRGTTSAPTAEPPGFPIEASTYSLNFFFDNTSGNIETTDEDFVQLGEVTQLYFDDYFDRKYGSTFIISFKEALTQVVGFSALSLPIETFFFTTVIFSETSIFYPPLSEVEREIEKAFITFGSNFEYLMAVRGLPTSNAFQTVSSVSWVGFGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN34</accession>
    <name>A0AAD2CN34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="4">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="288"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1940418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="435" mass="51256" checksum="D55C8D95C5D1E07A" modified="2024-05-29" version="1">MPAIKGTSSVSDLRARRKALKGTRFPDNFAQAVELEKVNKQVLTQWIEHRVTSILGFEDEIVSSMAINLFLPEEGESPDPKRAQLDLVGFLGEEESASFARDLWTLMLEAQENATGIPKTLLEEKKKELAAKKAESRAAQGEGRRDPDMNRYLQEANRRANAARGAMGGVHGRRHDQPSVPVSPPRYERQSSENRNGRRQHQPDERRLPPAHRRPGDNPPHPGHQHPGRYDRDGPRMPPGLPYGFDRRHERHMSRSFSPDRDRDRTRWGREEGRKDDDRGRRNERPRFYDEEDEMRFLERRLGSLRREYSNRPNDYALGDEIDDINDRLHELDRRMRRYRRGRDEDDYRRRGGRNSPRHRSRSRTPEIRRRRSRSRSLSSESRSRRRRRSRSLSSESRRSHSSVSRSSRSHSRERGRRRVERRYSSESRSSRHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN84</accession>
    <name>A0AAD2CN84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041917437" description="Thioredoxin-like fold domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31521" checksum="1C6DEC2A5720FA89" modified="2024-05-29" version="1">MKIVRGILALLACALNVQAFSSLSGIAVSPVKGGDAVNLEQYLENPNGKTLFIFGTYAADFNAIEYLQRLRHYIPRLKECGVSKFGVVLNCQPEAALAVAEMVDLDTSEVDIFVDNEGVSRKQFGVNTGWLKDNDDVNPYVKLFGMLFGLGAWATLPAVIGGYIGNPFVPQPWIEDALAVGQKKGRWPDTALQIGDDGSVVNKFDELPVVGDWPRRPLELATLRLQSMIGISIENWSELAPDDEALQAGVLTQLGGCVVTDSNGQTLFERKDTGICAVTNFEILLKKITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNC4</accession>
    <name>A0AAD2CNC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000946">
        <property type="protein sequence ID" value="CAJ1940731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="180" mass="19674" checksum="3966F5B0EAD47548" modified="2024-05-29" version="1">MTEEADNEMIVDETIGEGDAEDYNEEDDDDDDGNGNGDGDGDGDGDGDNQEISLDRIKTECSAMVKLLKNLQDEEQNLDCQLQILAREALICGFDIDMVEPPQPKRRRMTGKKRQPQTVGKQDKAEKRSSIGSTATANSTEAASVSELVAAVLNSAETQDEEENNSIDVEAEIVMDDQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNV6</accession>
    <name>A0AAD2CNV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000681">
        <property type="protein sequence ID" value="CAJ1938180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="210" mass="24237" checksum="729D7C87666B8A5F" modified="2024-05-29" version="1">MGRSSSSGGRRRVTPQKVKSNLSSTVVKHLFSTKDENDGKARSLYKDAKERVIDYIQASGMKCSEDMVKSIQDVKSIDFNAIAPRLNAPTQTEAVARETEMAQNKILYSAKLDENMQRSAYFETNKRTVKSNIMLKFVTKAMDIKLRGEADFMTTLEDPIKLLKRIERFMKKSADAEYDFLDFWEANQKFFAMKQGTTKNLMHFKERFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPS0</accession>
    <name>A0AAD2CPS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000976">
        <property type="protein sequence ID" value="CAJ1940904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1940904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="135" mass="14163" checksum="299015BB516C9E0E" modified="2024-05-29" version="1">MLKIHMEVIKNPGVNLYQGKDQPNKGKGKGKGKGKPKDGKKAACYVCGNKDHMSPKCPDRLLPKTQWKNQDQYVDYGKKVNLNQIGATVPATVPAIVPGASASTSGASSVAGSVNTPLQLAGTTGNQMMQVPAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQC6</accession>
    <name>A0AAD2CQC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Shikimate dehydrogenase (NADP(+))</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041984361" description="Shikimate dehydrogenase (NADP(+))" evidence="1">
        <location>
            <begin position="17"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="2">
        <location>
            <begin position="486"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="3">
        <location>
            <begin position="737"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="85474" checksum="3B0A97E9C7479300" modified="2024-05-29" version="1">MIGITLIFALVPAILGFVPNGFNHRRPNALNMISDGSQRNIFHNYDKPIVLVGCSGEGNELKRLAESFLEENFPQVPMNIIKPTTDLVLADISSFASPSVIVVDFGAETSDDLDLAEVTRSLYEDNDMLSIYVNVDAEEGKMSADSAKTKSEFDESVFMKYSDYELCIKGEGTEGESANWDHIKWELTRLVARARLAPAVPGEKAPSTNTAHLTMGENTFFLSLSFPEISQVEPYVEEMCLDVDAMEYRTDLLDCRDSRFDLIYGMQLLRRYCRPYVLRVPALPFVGDVLEDVMPICYTVRTQNQAGTYPDDEAGISKMFDMLGWGLRGGVEVLDVESTWDKKKTEDLLDGAKERYASQVLGSHHVVGQEISREEAVELFQQCALDGRAHGAKVVLSIESEEKDRMAHEAAIIAASLAAKEGKPVIPNISLILGDIGQFSRIVNLPFTPVTHESLPVKAAPGQLTAKEIMATRLLMKIVEPKRYAILGHNIAYSVSPQMQGSAFRATVLPHAYGRADVETVEEFVESDFFKDPSLGGCSVTIPHKQSIMPYVDVMSEAATTIGSVNTLIVENEYENDDFKRVIYGDNTDWKGIFNPLERRVGVQGEDSKGIALILGGGGTARAAAFAASELGLKRVYYNRTPSKAEQLVESFGGSVITSLDMESENADEICLGDVLSGDTSLKVIISTLPAGAEFVLPDWLIAKEDVKPVIFDVNYKPYHTKLLEQAEGAGLETVRGSEMLWEQGVGQFEAWTKRTAPYAVMKAVVLQNCLPEDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQM7</accession>
    <name>A0AAD2CQM7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS8145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQM7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000016">
        <property type="entry name" value="Propionyl-CoA carboxylase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="58"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="319"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1942836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="563" mass="61406" checksum="5E496499A62DADE1" modified="2024-05-29" version="1">MLVRVFNKQATNSLRKGLTTSSFRCVSVTKDYLKPTKRGFASAVPVEDNLDSNPAMMKLKFQERLQKEREQALMGGGQKRIDKQHAKGSLTARERLELLFDKDSFQEMDQLKAHRCTEFGMESKNFPGDGIVTGHGLVNGRHVYAFSQDFTVVGGTLSETHAQKMVKVMEMAMRVGAPVIGLNDSGGARIQEGVDSLAGYADVFQKNVDASGVVPQISVIMGPCAGGAVYSPAMTDFIFMVEDTSYMFVTGPKVVKTVTNEDVTTEDLGGSKVHTAKSGVAHGDFANDVAALRAMRRLLDFLPSSNEKETLPVKEATDPADRLVPEVERLVPDDPNSPYNMKDVIGQIVDHGELFEIQPDMAGNIITGFARMEGHTVGVIGNNPLTLAGCLDINASNKAARFVRFCDAFNIPLVTFVDVPGFLPGTEQEFGGIIRHGAKLLFAYSEASVPKVTVITRKAYGGAYDVMASKHLRADANYAWPGAEIAVMGAKGATEILFHGEDLEAHTAEYAARFANPMVAAQRGFVDDIIDPQDTRRIICNDLRVLRTKKMPEIKKKHSNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRS6</accession>
    <name>A0AAD2CRS6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000773">
        <property type="protein sequence ID" value="CAJ1938806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRS6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="341" mass="38658" checksum="453A4299DAA3EAD1" modified="2024-05-29" version="1">MVWLNNVWYELRSNSSCSHFRLSSQGKLVNCPVLLLRKVRNIANVKEKRVGAPAQEKLDLDGVDTRGVKDHRHPSSKRVGSWATRVWTATYRIPIELPGMLTSAVTENFGKLTLLRFLIAVIVTGAQAKKAEDAEPKKPPAKAIEPVEETKTSLLTAPKSPEDDDAWIDKLAQLDLTNDSPSPLFVMILPAKEDGCYFVVVRQRYLPLAMNVLDNLPSFLQFHLGELSFPNFIRVIKNWSATDLAYQNRKLHIEWVPSELRFRCIDDPTDEQGPQVRDPMDFLLCMEDPVEILEGTLHIDIHAKHVRDVDDGLSVLGYLDDWNNSRPLFRPSRLSLTRGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSH7</accession>
    <name>A0AAD2CSH7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSH7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="101" mass="10545" checksum="DE0062B0E98706DC" modified="2024-05-29" version="1">MGKNEAASNNTTPTQGTISPGGQGGKGTPPFPPNKKATFHNVSATGLELVALPNFLHSNSTLSEASETSSLGPAPSLNLKMRRSESCPNDIARTQLFPHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT91</accession>
    <name>A0AAD2CT91_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastid lipid-associated protein/fibrillin conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36348">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36348:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042109191" description="Plastid lipid-associated protein/fibrillin conserved domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34906" checksum="4D05028DED9DE420" modified="2024-05-29" version="1">MKFVVAVFAVLSVTQAFVPLSGVRPAIGSSRDFLLKASDGDESPKPPKWSRIEGNQLEPTAKDFEIMDEMITKLANAAPYELPNAVRRAFRVISSPKFFMRIAERTDATEDPVEKAKLGSLASNLVSTLEVVVETTEETLDERAREVEAVLKAAAEPETGEFLVPLLPTQVQGMRKTLEALEPSSLDEGFLSTVDAWMNKSHQDGMDGMVGILQKVLQMYSGIQIKRAKENMESAESTPASELFEKLLQTDTELWDVEIRNGTKEIKCSPLVREIQKTMESVVLGLENGSMAQRVQAEYLRELITRVEAIQQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTH9</accession>
    <name>A0AAD2CTH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TPM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001402">
        <property type="protein sequence ID" value="CAJ1945407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35514">
        <property type="entry name" value="THYLAKOID LUMENAL 15.0 KDA PROTEIN 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35514:SF1">
        <property type="entry name" value="THYLAKOID LUMENAL 15.0 KDA PROTEIN 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042133998" description="TPM domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="TPM" evidence="2">
        <location>
            <begin position="71"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="145" mass="16119" checksum="E8008C051219F64A" modified="2024-05-29" version="1">MKVLRRTLLVGCIAFAAAFAGETTNGQHCRRKILQGAIGFAAGVAVAPPAFARLESVNRPDLLPAEDNLHVIQTEKFLTNGQVRRMEQLLVQLERETGFRIYVLCQNYPLTPGLAIRDYWDLGKEGQKDDKYVVLIADQFGGRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUF7</accession>
    <name>A0AAD2CUF7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001602">
        <property type="protein sequence ID" value="CAJ1946125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUF7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="95" mass="10392" checksum="6E14E0B29934D236" modified="2024-05-29" version="1">MLNRTKSALIYSSPWSLDIYDSIKIVSLTRSGPNLNCLSPYTNFLNRSSITHERARFLNTISSIQVCMTSSLGPDTRRPSGGASSFSTGRKGSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVG4</accession>
    <name>A0AAD2CVG4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVG4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="149"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="238" mass="27120" checksum="104ED57EDAC457B8" modified="2024-05-29" version="1">MIQKMPPFYDTPMLIMTDTIMDTSSPLTEIDEIQIEQGTTTGLPPTISFIEDHYRDNDDDLELDPIPIDSMIDGEGEEALVSFAASLDCCFLGGNEQNLPTDPNSGDEQTIITRNKKSDYKGRRVRTKRRTFSKIKDPNGYAVECHKNDVLLGRGGHASNNPGNLYLLQAVRMYSAEYKSLAKTEHDKVQKRAIVRHIVSQMETRGSRFLYREKKGEQWREASGRAIYEKISHMLRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FAJ7</accession>
    <name>A0AAD2FAJ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4954 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1895120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FAJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032533">
        <property type="entry name" value="DUF4954"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16314">
        <property type="entry name" value="DUF4954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4954" evidence="1">
        <location>
            <begin position="44"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1895120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="686" mass="75052" checksum="4CA94A26A3D0F776" modified="2024-05-29" version="1">MSLELSDDFIRVFTARDAQLRDISRLLDLVGAQFNDVTDRHVIRSLKSFEVQTLESCRCTCTDWSTLRVLIKRSEQSSDLSPILKGLVSDTRFDGAVILIVDDDDKTSKSGLSKKGAAKQNLDKLPAGIHSNLMVSDSIIHLKSARIYRNTVISKTFVGPDCTIVNCGMISAPNDYEIGHIKLSVGPESGGGRPLHLTLEHTMIDVCRQLRSKPPTSSTTSAIQNINMNVLTKSNVLRDTPTIENIYLHENASIEAATSVSKVTMLPDSIIGSSCTVSNALLQWNAGVSDNSSITDVLLMERAHCGPSGIVVESVMGPDVHTSAGEVHASVIGPNTNAHHQSLVIGVLWPLGRGNVGYGANVGSNHTGRLPDQETASGEGTFWGLSCVIKFPVDLTFAPYSIVAAGTTLSPQRVCMPFSLILEQQSGGNEIIPGWVLQSSPYTLARSEKKFATRRKAKRHDFYTGWKIQRQEIIDMCRWARNVLQQSSGENNKVPGVGANQLTGRARSVGVKAYTECIQRYALHGLLTWISQGMEQGGQNPKTMLESEFLAKGIPTPQSPIDPLANVDWPPMPWDMKAVDEWNFQKAVLVEEFGAPPASDTIVWITEVLERLVYLEGDFARRIHKSKARDDVRGAKTIPGYANAHIAADSDPVIMEARKNADDVKIQVASILGHKSTVLRKQRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCJ0</accession>
    <name>A0AAD2FCJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide-methionine (R)-S-oxide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1918373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042114240" description="Peptide-methionine (R)-S-oxide reductase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1918373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22976" checksum="156A202EBEE6ECF4" modified="2024-05-29" version="1">MKLPGIALLVLGVSSSIRSSAGFVSPSIKAVAGRNTQQQLFKNLFGTAAGSSKYPVMAEESVMGPKAHGTSEKPVQKDLKWNCDFEVADRICNFNRHYAEYAGYWQTTDFIKSIKEEEQPIKFYDSVTGAHLFTAPVGRTMEEFLKESQGHGWPSFRDDEVNWDYVRCLNNGECISTTGTHLGHNLPDGSGNRYCINLVSVAGTPEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEK4</accession>
    <name>A0AAD2FEK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051918">
        <property type="entry name" value="STPP_CPPED1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43143:SF4">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43143">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, CALCINEURIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="635" mass="71175" checksum="CC68C2F6F3D58C47" modified="2024-05-29" version="1">MKTSNSKIQLSLAITMMIPPIVVSFTPPTLRSRQTSLRTETRLSTPFFDRNDGMANRSELVDAKDWIDAAVASTLKSGGFDESSFLVGILGDLHIDPRKMEDYEEGKNDWKPIFEAAQQAHGNTCLVSLGDLGESKNCDHNKDNPAELFSGTTLCHEIAADFLGNVATGVPYEVIGGNHDLEGIDEFATDEENLEAFMKAHNKPTPQFCHQVADKTLLVGLGSTVFRDAPYTSHEVIIDQAQIDWFEDLLKNHPADDDWKIFVFTHAPPNGSGLRIIQENHVVNGCCWLNHSDESQCRKFIELVREHRCIKAWFSGHFHLGQDYQDSITFPTIPIEEGPYPHRGSCVFAQTSVMRKGTSRDGRQQSRLLRGNKHGFEICTVDHQEGGKIRLDATITYSDNSNEVGIYMHDDAAYEHDNYFKVYQPTEGDLQYVRGADTDEQSSITDDDPVTMDTKAWWRLSNNRVLGVLNGMLLEYDESTLAPLGLVLTKEELLGNSITVVDSGIEDCFTEFDDASEGMEGAECCKEREQAILVHDLKTNNVTIAQPNEDGSYWRKIVRNKIARMEEKRREQAAIQYIQEQAGLDDKDAKTSIQSTWVSGNGYEDQLCADAFYQSLTFVFMNQQGPYTSTSGNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEL1</accession>
    <name>A0AAD2FEL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEL1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042085356" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="170"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="317"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="446"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1935150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="654" mass="70143" checksum="9BE0C9804917F45E" modified="2024-05-29" version="1">MKISAIAFLTTAVGLATAQNGTEPFAADFSPIVEKGSYTSLLGAINETGSDAVISSNAPVTIFGPWDEAFDNITDVLETLTTEDIQGVLLNHVIVGVNLTTEMIAAEGCIEATTAGGLEISIFRDPFTGLIDVDGFHVVVDPDITGDYGVMHGIDRVILAEEHKFFPCPPPLDLSPIAQLGNYSTLLAAFEQTNNEFTIATNIGFFNTTIFGPSDAVLAAIQSTLDELNNDELNEVLWGHLAYGEIFSDEFRALECAEAETFAGTFVAVRFNRNTGIASVNGIPISSTNLDIDGEGYVFHGIEGVLVDSEYVPCSADPLDFSSVELAGNYSTLLSLVAQTGLVDELKEIRPVTILAPTDAAFARYQSNLTGLSDEEIAEILRIHVIAFDTIDAQWILDSECMEFFTEGGSMVSFRYDNVTEQITVNGIPLVQADILGNFGVLHGIDGNFAFDGQYEPCFEDPYSVVGYLTSYYDQQVTEAAVAAFASSATFFGPTDEAFYSLDEYPFYSDDAAEREVELLLGHIVPGIHTAAQVKEAGCVILDTLAGTKVRVMWVEGDMGGRRLAGHEMTGMVMVNDAMVILADQLDEESDVMFHGIDKVILSGSFSECPSTMSPVTAPTDAPAPRGTPPTESSAAFVNHVSIIFASMVALLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHS9</accession>
    <name>A0AAD2FHS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS6870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHS9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1940098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="385" mass="42833" checksum="D345253F2A4E4185" modified="2024-05-29" version="1">MPASKVLVVGSGAIGLRTSLELLRKKVSVILRSPRSPIDTSVCSQGAGGLWMPFHCDDPRTDRWAKETLDELYPIGKDDSKSLVELVPTLALHRNNHGPTTLDFTRNDYASGTGGASQLPAWSTDARLQFQHMTTEMLYWQNYINRLKIPPEQDILAAGYSYAWLFNPPIVDCPKMLETMLKEVESKGADVNVETGMEYESLEEIVDDAKSLGCDAVVNCTGLGARKLCNDQEMVGARGILLQYDRQDCVRTEDIAFREDGKDTNIMVEEGPWGSEEMPCYMITRGNTVVVGGSYLEGDTEQDIRDHERLRLLENARLMGIDTEKSSPVGEWTGFRPFRPTSRLEVDAKFSNEDMQIVHSYGYGGSGWTVYVGAAKEAARLLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIT8</accession>
    <name>A0AAD2FIT8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1942136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="217" mass="25085" checksum="6AB00DEDC15A4E97" modified="2024-05-29" version="1">MNDNFSSVVITKNEDTNNYETRFLDDVVVPERENFRFRKLVSNKRKRRSSTIVDQMGGEFRLQALVMYLSQRVLGDSRLSSVFGSFSLKALALLLGDMMWYALDDSFDACIEEKKHLKSKLLKKLCRLGLMDEAEYFDILAEHFLNSMRMCSFRNTRIITQLGDRFLSLRAALQEVADRIAVKTTKFPATLFAFLRNPISWCTTQSHRSVISDSHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJE8</accession>
    <name>A0AAD2FJE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protochlorophyllide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000447">
        <property type="protein sequence ID" value="CAJ1935315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1935315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12288" checksum="C95766C9CCD897E4" modified="2024-05-29" version="1">MGGIFSSSSKKVDYSGKLIVITGGGSGIGLEMAKSFSRDGAQVVITGRTKSKLEAAAKEHENITPFVCDVSKDDDMIKLRDAMEKKGGVDFLVNNAGVAHDIDFLDETNKISTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJJ9</accession>
    <name>A0AAD2FJJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041928186" description="Subtilisin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42432" checksum="C14B4E9B6C3CBD61" modified="2024-05-29" version="1">MLFQSTIVASLIVSAAALRPNNGIPADSKAGMKLLSEARQLNQEEQDDDMSWIAGYSIKYIGCSSLLQIREDGGEEGSNLYTMNLAKFALCDSGNSCSSCGSGAASYVVNMETFVDAYTEMALNAQETACENIRENCDCENANDDDACENQCYTNMGMDSCIEYEGGEEFEIQEYLECREIENENGNNNNNNNNGYYQQYYVGPTCSNGFDINLAVFTDEGCSTKATGSGIYESMNYYGNSLPYEKESIVSSDCISCIDTQNDNGDDNQNNNNNNNNGQQEYDILELCENTYEDAAKCEKSLSGKYYNDDSGCNYINNVLPTLEKATNSITKSSGSRSARTGDGSAATGWAIFFFLTAVVMSAYAFFLYRKIHRAKVNLSSSEGQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJU4</accession>
    <name>A0AAD2FJU4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001333">
        <property type="protein sequence ID" value="CAJ1945068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="332" mass="36758" checksum="B1A448878F47811D" modified="2024-05-29" version="1" fragment="single">DLWQTTLSRALLASNGPHHPLQQPLGPWTDRLEDWNWLLSPTTGLFHRHGATWKHFSSEGSPTTSRCYAPGPSHPSCPWWTALLPSDALCATVRSITGSDRVLLTGTGRASELSSSSSPSILHAWQTAAKLCTDYYGWVPDEIEVHGDEATLADALLDGRLRVISDGSFKNKLGTAAVQLLVKHGGCHQTIIRCQTPGLPQDQSPYRSELIGLLAGIMAVDWLLEQWFPKNLTGPKVRIACNGLSAIEMAFKDRPLSPTDAKFDLVSSIWEAILRSLVDWAPQHVYGHLNKSNLFDELSWWEKRNLEVDGMAVEYRKELETANHLIAPNVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL48</accession>
    <name>A0AAD2FL48_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000780">
        <property type="protein sequence ID" value="CAJ1939342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL48"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="13861" checksum="BEF88FAB3A9A4E21" modified="2024-05-29" version="1">MKTKVIAGFPNDAVDKIEIHKGVRKIFDPEYEDSEEEDAPIGDEDNGLVHRYAQPDGWDSDEANDNSEIDNKTDDDADDDDEDEASEESVIIVESTRPTMNLVPADPAEVTTLRLAPSLMKQSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLD1</accession>
    <name>A0AAD2FLD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042182501" description="HMA domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="38687" checksum="452DEA4F97D41749" modified="2024-05-29" version="1">MRLAYNQSFPLSLIVVVLLLVANQAFSFGIHRQPISSHNLQQSQFPEPKHRRAVFNRPSKLSAGNSSLNQSSETVCNQSENSRTPAAYSYHLLWTPGFARKLMLSTLLLTVGHNFVFPHLVASSTSNASMGWISSFLLSLLASSCCLIQMIANVLISTVGCLGLNTALGPVRPYFFSLLLYVNALTIKKGLSTIPQMVMRTIIALLPEGLHLWTNYRNKRYQSINTEVGVEAGDVSATVESSINSSNGSFSKEVSNDRSINMVMELDVPTMGCVACINKIDRLLRQSQEQSTESNKVRSVSSILDAEKAKGGKAVVKLSVGSTEEAEKIGNSLVEQLDKLGFPGASIISKETVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLV3</accession>
    <name>A0AAD2FLV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS8273</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Longin" evidence="13">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1943092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25581" checksum="4C2173836C577FA5" modified="2024-05-29" version="1">MPPLLTQVARISDGLPLVASQTPSPGTPLTNQHQKEAKDILRKITTGTPTKMSITSGDMVFYYMTRDSLCFLTLAEARYPKRLAFLYLDEVCDMILSELVKEFDSNWRTEVDKTARPFAFIHYDPIIQRKQREFQDERLQRSKLNDDLSEIQSIMKKNINDLLDRGEKLDNVQNISQDLLKQSSGFKWGTRKLTWQARLQQAAPILVGGSIVAFVTYVKFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM74</accession>
    <name>A0AAD2FM74_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001319">
        <property type="protein sequence ID" value="CAJ1945040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM74"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="332" mass="35891" checksum="0D5035ACE6EAD36E" modified="2024-05-29" version="1" fragment="single">LSLGVVHTCATTKATKELYCWGSNDSVDLLLKRPVSYHTPQHIDLGGQGIFQNNADIDILQITSGRSHNCAVVAYPSFNLERFVCWGSNEFGQLGIGSTEDGFESPVQVASTLDIDLLPQQISAGYSHQCAIQAADNSLWCWGLNSNGQIGVGTTNTNVLTPTKIAQLGSVSTVSAGSYHTCAISTTLPESTFLDAREEEDGRKEGNVYCFGYNSFGQLGIGNLEDQQLPQKVDLGGFAKDIKTGRDHTCALMEDETVKCWGSNFSGQLGVGNNRESSMTPVTVPDLRDVQKLALGREHTCVSKSDQTLWCWGTNLHGQLGLGENVSIQYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM93</accession>
    <name>A0AAD2FM93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="68134" checksum="1438AB7BD1241885" modified="2024-05-29" version="1">MPRVGDGTFGQSGNYVTNASSDDSLDAMIAASSQQQRISAAPMSAPKANAQSPVPSSILRTGSHYDGAALSPIRQGAALELPTTNSALPPRGAPVSTSRVRVRAAESNFRLGSGSSSVNSSRQQHWGMELPTTIETTTSQKPETTIMSRTKVRAAETRSRRDDSMQLPSTRVVSDTDVGTSNKKQIWRAAESGSSPLLPDYSSNDNNHNSNNSASRRRRGAPAQRAPPDRSRTRSTPSLRKIVMRGVNGGTSPVLPQTTSESMSAAGPSMPQRQTSGGGIRRRTASTTGSDDEDLYSYPSRDSPYKFKRSRKHGNWYSWRNLTQLKVGHMAQALFILAVTVLVYESHSKAIFAANQLSQFKEEESLLLLHLQKIEQQSIQLHENLSRLAQSGGPMEPLMEEVEKRAESGDVDFDLIHKQTQQLYQMEEELNHEVRTLQAKIQQSARNHIIQAFGEGPVQVILELEFPEQSSSANQISILLWHDTPHAAWTWLDQIGKHTWDGAKFSWQQSHMIDAIPVHVDHSGSRIEFVEQSQHGHDAWTVGLRESDMGDLQMFFNLQDNSNIHKHEVCVGKVIDGFDVLQHLLETSRAQKKSDDNVIRVRTATAMHVTRVENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMP3</accession>
    <name>A0AAD2FMP3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMP3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="25748" checksum="A99ABB6B730D57FB" modified="2024-05-29" version="1">MQPLQATPEMCYYCFEVLIGALVENRTPGRLPGFVNDLPDRLVECPLFVTWEKMHNRTWQLRGCIGTLSPRRLDSSVGEYALTSALRDRRFHPIKKSEIRSLRVGVSLLIDYEVCRDVYDWTVGVHGILIKFQMGGNQFSATYLPEVAQEQRWDQATTVMSLIQKAGYDGAVSNELLGSIGCTRYKSSKCKVPFDEFVSQKCQGQSPLLMNNDGNRRRDIVAAGCKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMZ5</accession>
    <name>A0AAD2FMZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="222" mass="24914" checksum="573D2B6D584C11D5" modified="2024-05-29" version="1">MSTIRIRTAINQNNAAASMIDTARYNEAICMLKASLKRFQKELRSHAAHDNVHSEPCATAIHHLILQSTTTSLLDRREDSNDDAGFLYDRAVFIPQRVSLERHIATHVVSSIQIFNLALALQLKANATNVDSRLRDSYLRKSMSIYQLVMMLNGKNSLLSMIVLNNVGLIHRACKHHDRASECFNRLLAIWIVSPGWANYLEGMVHNALGWYDTVAFPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNE1</accession>
    <name>A0AAD2FNE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS10989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="490"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="718"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1947123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1644" mass="185464" checksum="75D2CDA40A14270F" modified="2024-05-29" version="1">MHGLVFEIFEDWVIELHGLDAWHSIKKKAGCDVKDKSFVTRTFYNYDIWIKLITATSQEISVSFDDVLEAYGHYNIRYHFSHGHDALLRCQGSTLRQWLSNLNAMHDHVQKSFPGENFCPPVFWCEDCEDVEGSILLHYFSQRGNLLVPWVVGIVEELASFHFEVEVKLNRIAKQDEHDSKFTTWRITAVDETQMWKLSPSTMHNEEEVIDFSAVKLPGKCPFTGKKLRKDMDSSENMCPHAKRELEKMEMEAATASVSTDTSLLTESEEAESGLSMNKMKEVFPFHVMVDKDFKIAQVGEKLPKLMKTNINDLLGAHIKSVLKITRPVLGTSWDWRSLNKLSDQNFFLAPATEESTADTRASMHITADGQQKFGMEESVVKFKASIVHLAEDKVMFTLSPEARNVEDLNNMGLTLSDLPLQSCQRDAVFLGEYITQEADKAHGLDKLSRKLGTEQALSNTLLYNILPRQVADDMRKGKTIEPKFHENVTLFFSDIVGFTDLCGQVEPWNVIDMMNQLYSVMDFLADRFDLYKVETVGDSYMCCSGLPEPDQYHAENVANFALAVLECVKHVKSPVTGEPIDLRIGIHTGSCTSGVVGTLTPHYCLFGDMVNFTSRHESTGAAGKIHASSHLFGRLTHFAQSDNQEYSFKARGLVDMKGKGEHYTYWLESGTEHNESANPTALEALSEEVEAMISSRKWKMRKYFKHGGLFRSEQEASGNLSSSNEESSGYHSTSDSSNGMSQKEAGSVHSDDGDILDDIEEDDVIEDPIANLVRIEGLEQLADFGNGWEDLEWGSCSKDALQGKVFDILMNVLQVCVGKGGARLNIITSQLEKYVQTILDLYSEENSFHSFKLAAEVVLRANFIWDAWATDVSKDPWDHFMLLFAALIHGVQHAGVDNAQLEFEDDVICTMYRGKQAYQQRSSFDCAFERLEEDFEELCEEIVFGCPNFRASVKKLVVSFTDLESEKMLRAMVANFEEIIAKTSKNQRVLKEQREAKVGLVLAMSAIGHYAQSYDNFLKWNNLNFQEHLKAHRAGRSEDPRDSWYYEQNMFFSDAIMPLVNQIEKFLPGATCLGDCVLRNIEQWRRNGRDRLAASLVPTATVEDYRGEKLSLDRMGALIAANVDMLEGLLKDIVACHAENRIRSCGTSSRRMSMPVDEIQMSIAMKNKTAEKFRPTADLPPHVRSELRDFVITIASGYESNDFHNFQHASHVAYLSNLLVNGINGIDGSNDGSGIGCDPLARFAIVLAALVHDVGHTGVPNGQLAVEHPTLAEKYSNKSIAEQNSIDVAWNMLNSDCFENLQHCIYEDAGERERLRQLLVNCVMATDIFDKDLRSIRQTRWDKVYSDNEKLHSAEEEEHLKATIVIEHIMQASDVAHTMQDWELYRQWNESLFMEMYQAFLDGRSEKDPTASWYGGELWFFDNWVVPLATNLKTCGVLDIVSEQLAEQAKSNRQQWEAEGKEICEAMFEKVKAKVNNRSSRDLRSVSSMRSTESEIMLTSKMVNEVECLSKVVKRYERKMAAACGNLIAVAYKGGPDGKDLRKMSSGDIHSHFKQQDWYKMYSDDELSVDGSLPSVRSTKKNQGKLTSHITRSRKVGGRVSFLSSGSKDLLEEDDFSSIGSSVSGLRSQLMIAEKLIASSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ72</accession>
    <name>A0AAD2FQ72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS12037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ72"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1949324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="481" mass="52524" checksum="C8BC3248FD20B62A" modified="2024-05-29" version="1">MTIIGYSGRGRGREKGRGRGRGWGRGGDRGRSVTYQSYAGGQGRGRGRFSYRYQQQQLYSASSGNSGNPSHKWVRNGNEATNAESNGNLGEEKSTQEQDFVKRGKNQLILKTDKPSGLYSEKNEESSTKTSSDSKMDGESIGKPESEHTDSQLPNTSTFVIIETETNKLISSGSRNDTSREEDKPDAQSSENKMEDKVDTTMPSQPSSSQKPAPNRPAVSELKVNSIGNRSAILGADGSMLSTHLKKVASHKLVASGASSKPGVPARRTNHPGPPHWKSGNTKKRPPPRSGRPRPGAAKRIAIEVTNKASGEQEQPITQDGSTANEGSLSSEPTEKLTDFAYRQTSARVQRGNDSKSLKWSANGGSTVSSSIHQSGRPLRRNMGLVRVQPNTGKTPICKTFLRGINCTDKYCKKRHDIPKEFSVPVCSFFQRHGNCLKGESCPFRHIKVNPRAMVCPSFAVLGFCDDPDCNMKHERSKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQC2</accession>
    <name>A0AAD2FQC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Erythromycin biosynthesis protein CIII-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="2">
        <location>
            <begin position="408"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="566" mass="62531" checksum="471486827077DC9C" modified="2024-05-29" version="1">MHVIMISVGSWGDTEPYLALAQELLTNSNHCDTNSTNNKVDFFVQSQYESRVKQVTTTTLIGDDDDDVDVDDDDDDSSLQNPFHQNNFRLHALPFSTQDFYKVKPNTTTNNNNNNNNQDPKLKHVATVAEIMGELVLPCARWILDSIAPTIANKSNTILLSSALSRPLGLLLAQVLEIPMVLLHLQPLVPNTIFPLYRVVPIETCVQAMLLYNNDDHNQYYEQTYWKIDHPLEEIFLRDRLIAAYDQFGLVPPTWSELQTILAGGGGGDANDDDDDHASKIHPHHHQEVVHIVNCYSNHLIPSIVGTPGVGPNVHEIGCLADAYIPWNYKRTLNPDLETFLQSCKKMKNTRPPICIGFGSMPFSELSAVMDALIELEDIPAILVGKPFQFTSCPPRYQDLLFTSGKVFRMEFVPYAHVLPKCSMMLCHGGAGVVHATIRAGIPCLVHPIMGDQFLFASLLEQKGLGVRIIIGTGGDGGGDGGDATSKRQLLQACDIVRAVRKVDSSSSSFSFSSSSSSNSIRTNCQELRQKIITEENDAGIHHPHGVVQMATLLQQIVLGNNKRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR05</accession>
    <name>A0AAD2FR05_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-phase kinase-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS12328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1949913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19410" checksum="52565DBDB1291BEC" modified="2024-05-29" version="1">MDVEESNATVNLISKEGDQFPVPSGVANMSELVKSMMDDDEEEDEDDTKEIPLPNVKAQVLRKVIEFCEHYLEEPMTEIEKPLKSQNMADVVQQWYATFVDLEQVLLFELILAANYMDIKPLLDLTCATVASMIKGKTPEEIRATFNITNDFSPEEEAQVREENKWCEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRP7</accession>
    <name>A0AAD2FRP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001777">
        <property type="protein sequence ID" value="CAJ1951046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRP7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="103" mass="11825" checksum="8A662D8E575AC756" modified="2024-05-29" version="1">MANVGSSKPPHWSEEEIKALAIDYRKVSEDPVEGLKQTGATYHARIVEEWKKQFPSGDDRRHGTWSDRNGDTVANYFRDSIKAKCSKSNMRKDIRKWQNGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS26</accession>
    <name>A0AAD2FS26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001763">
        <property type="protein sequence ID" value="CAJ1950361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="153" mass="17021" checksum="D1F4F15EF015F546" modified="2024-05-29" version="1">MGEHVTKRASKKTKLYSKGRCASIADIKSTISNVAQLADFATENFSMSNNTPFLVEQFDTVMVALSRPDAVQWQHVIDLTGVAVHILHDLQTVFQVIASEAKDFTLHAEARYWAPFNVLNSSLAQEPRHSSCWTRLTKDYKIVAAPTIPGHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSD8</accession>
    <name>A0AAD2FSD8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001791">
        <property type="protein sequence ID" value="CAJ1951621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="343" mass="36708" checksum="C0C7F2B9AB1E9532" modified="2024-05-29" version="1">MDLENNVPSPLFIMVLPGEMEGTYLFISRLKYAALATNVLNGLVPFFTHHLGELTTTQANRVIAKWLSMSLIHTTRRKELVWCLETLRARPSDQTLQGIDEAIDFLDGFGSDPLDVAEAKLEFDLEMADAKDIDDGATVAGAMDELLEKDSQLEAAITEIEFKVNLLVEKSSALEAERLRSESLANKLAALRLLQQTISSQEAQPALPPQNTATVSFPQDRSESAAADSRAKEPTLPATPARAAKSSPLTALLPSLPPRATTAIANQPPPRDTTTAASRRELVTPDHTAKTLSTPDHSNALDPGSGPGSSTPSLASSRVSDNASXXXAILGGFGRRGMLALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSJ1</accession>
    <name>A0AAD2FSJ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001797">
        <property type="protein sequence ID" value="CAJ1952074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="2">
        <location>
            <begin position="443"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1734"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2106"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2154"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2158"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2189"/>
            <end position="2233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2239" mass="249054" checksum="84CDA2D00C6E7782" modified="2024-05-29" version="1">MSSTRNKRKRTETDARSEGRPKSREQRDTALGQEKKLEAADTAANASKTNPGNNNQVDSILGAVATRYQQAIAQDASVKERDAATGDSSLPIPNSNSNDRHKGPLSQNLSSATKPLYSREKGPACDPSDGGLAHETNRSVRLQGLITHRSSLRRRIRFCAAVASERLQHESEESSYSKFELSAQKGGDMDEVSLFVQMTNSATLAAKRIRADNDANSDRRTSLSLRRGSSVGKRMNAALSSLAPGSSSNHSSSNFATVESNTKVPMNEKEQDLVQINMIENHPQVRLTSSVQQTLPSSNGLVQHANNPDNYSHRILIPSQLKQSKQDQPDKPEANSIDGNSSDNKGPELSSKISNGQESNNWQSSSTNSDRLALPLHLRVSSESLPQNRLTGRDMFSTKFSALRKQCDAIEARLSPYREQTQQNALILPTEKISMKNRLLSQRKTVSLPSRKLTHWDVLLQEMNWMATDFIEERKWKESVSRNISSAISSPSEKFPNSTRSPDDGNEKRREASSRDVAQSLHKDTQSDNGTENTLESVSTCSKLKEISTQTYPRNSQEGDKATRKVGNSIALLITTLGTAVMDTIDKQDFEHKKDSDCNHQNTRSLSGISRRKGRLRRLLPKNGSSISCGFRATLYGQKSFSFLEISGFVDSFAKMKGHQNDSIFQSFSSNSDSHLKMSLSREQKYVVDRVLSVWNQPTKPGIALRGGLCCGKTHTASVLMWQRRKRGPQLLICPTNSMIKWKFAIERLGDIRVLIYNLSAALSGDLSAEGEVLCKASDIILCEFELLDDPTLGTTGTSDLGVFAGSAYLLSVPWWDKLIDLSLQSNAAILLIEHSAENHWLHNLSKMPRRTKLEIVASRAALLIGPRLFLCDVERMQRRVFSWARQHGKIKGRRKSASAQEVLEEATACLVISLKSSDWTKEKTGWELRRCKMEKCQRSNYDACCIGVRGALSCGLAPLVTRSHESLCSVSQSLMLLRQQCIHGEVTGQLWNDYTHFTKGKRSYNTILKPIGIATENPAQMDSALAFRLIKGSAKLREMISILRFDCGVALADKLLLGCNILEHTVESSADKPRKVAIFATLPIARRFVSLLLNALGIPHELVEPTWSECMKESPLSSTKASTFSSHHQRMLACLNSSRRRGSALHPPLEIVVGCPAFLSGWNQGLVVENCDSVILVDDDWTGRGECVLSALLSRIQSHNFHQRKHCNFIRLICEDTIEEKLFSSDPFELSFFESTHWPRDKSGFLTVPETISEALPLYNSALRSEKRGFPLSRVVRLRHQPLSKTLLPSRTIPAVLDSTSKILFLPFTQMDSKNDDCEMHAELALMQVLCHEESVASSYCISYSDWDQAARDKNMHNSRPSRCPASVTRPLITKRHDFFILLYLQNLFVANDRRFESAFTQGLKNMKSSLDESRHSATVSASRCSTDKKPSTSRNALFGCFRMMSIKSFSGSPVLHYAPLQMQNQEVEIGSHGKTKELCNQESIAIINLSIAPQPCHNCYSRIYATSHVGNGAFGGYEGSEPFLFFPPLLKGEIHSGVLEHGQIPTLEVTKRKRVPITLVELPNSKRVRQMEPSSSAIPRFEDDSNSRFSSKAVNINLSAGESVKLQQHTISHYHNSLPKPPATTEVSDGHVHSFDDRMPTAISTYVTNRLDKRIVSRERHVYPVYDNAFETFENSLHHTSRKSQPCLDSVILFVKNAAIQNTGRTDRTRYDSNHARHSTDLNGVEVFASSGAEEEEMGNKKRGHKKMSHPQVAQRVPLVESSKAGHTHTVQASEELRKHSHRHRLYDFFHSRSTSSGLSMFECVPYQAVVCQVESRVTRTLGNQELHLGVEQEVLVPYQQVESDVSSTQNDRKHAGWEIVGGSSNLPDTREALLIGALKKGKSSVRSSIFGPQRGFLSSFRGMNAPSVPKHQLGISLPMGVKVSQEREEASLSAWSRKANSVLCDAVKRYDQNWVLIAKMMQKTLKVEVAKAKYYRTSEILWWKSAENCQKQWESISSESNDAVCPEGNVRSIRHSSFRKAPQETWCHSTGLQDSSVLVGRKCMMSVDRQKSENDCDVAVEQQRINADQTALQRRSNSVFSSLITSNMQRQLMPIAIISVGNGPNQNQTAHSHPSHLQSVQESATSHWSDGRTELWPLQIIDAAEKQHVASRALSTSAKPSSHSHVSSSTSPPAGRGHSYPRVPGNSATSLQSVSKLQASQMNGHNTSCPSNLPPKTSVSHNSLAQSRGKSSSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTA6</accession>
    <name>A0AAD2FTA6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent transporter ycf16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS13565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18560">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7_HMT1_ABCB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="271"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="615"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1952462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="96977" checksum="24BE3417F98CA1DC" modified="2024-05-29" version="1">MFPPEFSLDLDVSSSWLVVCAVAVNIQLLRLSVEYIQASNDSNSNDYKEEHHMKKTSTKGGSKSDLKKGLKESKTSSYGTLDPVPDAESQPLVGDNSRRLASSFAMLSFKLQCLMMLIFTVAVFIDVTTVISDWFVLFALLVVALGAPITLSDRYRMRFGRFQRFLYLLSAMLAWLPIFISFMKNREDATTGDYAVLLLISMYGIWSWGESMILPIPGEEDDDELYIAPPPDTKKELSRGAMIKMLRPYFWPDETSDSATINRIRAIFTWVCVILSKVCNLTSPLFLGWASTALAHEDYGKTIEYSILYAFIQFLGSTFKEGQSLIYLKVAQAAFVQLSEQSFVHLHSLSLDWHLQKKLGEVIRSMDRGIAACDTLMKYLFLWLVPAMVECVVVCLIFATYFDYLPLALSVFYFVWAYVVWTILVTLWRKKFRKAVVQSDNEWHDRFTDSLVNFETVKYFTAEDHERQRFGASVRKYQKGSVQVQASLSFLNISQRVILQTCLGVSLSLAAMGIKKRIDCCRDHGCDVGVGECCKAIDIDTCPGMQVGDFVAVLTYIIQLFQPLNFLGSIYNAVVMAFVDLANLSQLLAESPDVQDSPSAVDLPATNEFDPDIAVEFDNVSFNYPSQLQKKGLKGVSFKMKRGTTTAIVGPTGAGKTTISRLFFRFYDVNRGAIKINGIDLRSISQTQLRQAIGVVPQAACMFNDTIRFNLRYGKQDATDEELEQAANDAQLLDFIKNLENGWDTMVGDRGLKLSGGEQQRAAIARCLLKDPPFVLLDEATSALDTITENSIQEALDRLGAQRTVLVIAHRLGTIRNADNIIVLKDGSVAEQGTHEQLMKQNGAYAEMWNMQLHSTADRPPTPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTI2</accession>
    <name>A0AAD2FTI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="550" mass="62341" checksum="C779455D6A9F76F2" modified="2024-05-29" version="1">MGVSSSSLVSISVVSITARRFSEVHGWRTERRVSTKRTEDLEKTLFAMGACGMMETIESMDSDSDLDQDENDLEISIVPESYCDARILQGNAHTDIPSNFVIISISGRIGDNDGKVEDLLRLLRDDSRKWKEMTIEGGNNFGETMSRAFLSVLSLAMIKVEKLCLKTWYSQEAFYECLMSGLASPFCVRNLELSAKESHRLKMRAMCWHHLAEGLAQTTALQSFSFHSERILFRNRFTTYDDISEVLVDGIARNTTIRHLKLQSGNLTDDNIFPRLMKSLQRYPKKLESLMLSSRKITTDHLKDLAGYLGHEKCSLKRFEICSSRLSEFPLEFCNIQNESVETLDLCSLRGWDDFVSVVCPKLSRLSTLILDGSNVMDLSPLDTLLCDETALPSLAHLQLGHTMLMEEALSSFAPKLPRMRHLRTIEFSIFQTGRILIPFLTLALKSKTLEMISCRIDDHALEADLLRVLNLNKAGRRGIEIMSSGSRPLDVKLWPLILKRCLTVKYVLKNLRGQGAEAELHDKIATDNLFLILRDHAYIFDAIRQQVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUS0</accession>
    <name>A0AAD2FUS0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="145" mass="15548" checksum="2EC8B68F3B5F5A29" modified="2024-05-29" version="1">MMDQPRSLRRKKNLPDLQYSSTVGRLFESTTSATSAAPIASVTSNSVVHFTSAPTASPTKTKSEMPSLAPTLVPGRTEDPTADPTNSPTIFPSTSPSTPPTTVQSMNSALSEEETAKQSKIIFLSTFLGVYVLLGGGMAIRWLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUV0</accession>
    <name>A0AAD2FUV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rubisco LSMT substrate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042090122" description="Rubisco LSMT substrate-binding domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57976" checksum="04E222A37C981D40" modified="2024-05-29" version="1">MNRRRLPTFFLIQCCLILPNGGNAFVPCMARPSVFPVPAPESSPDINTPTTSGLPKRPSALFYNPLEFDDESEGKEGRMESVRRLQKSYYVNEPGFAPLRHGVLSSLPLWMEDYTELPGLQRVMDVRDPQLINLVLKIVAGPKPWYFGHVNKEDSDYDDDNSYDDDEILDSTIGTLMQISDYSLVKATGILEIGVQALGRFCAIEGTTLNVAGMKQVGVELLPDLELVEAHYHSAKEAIATFDLALNQNAKGAACAGAVAEAAEWHEYEFEPMKLKAKNGNADQGVSRLNAKVESSSNTVVSDAMEEYLIQSPDDAHEGECMLSFDDDEEKDGSLEVSELPPLEETTMMIQTFGLERDVWIQLDTLLHYLRLLDPKTNTNMPIPSQILALLPKDPPKPWPKTFTLTKYNQKMKNLQSLVSRNKSKLMLDKKIKLDTMEAASDYPALRRSRRLSYTVWILVEDLMSAYSDLIGTQRMILSRQDILEMTSISQRLFLARRKLEEINTVLSKVVGDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZH0</accession>
    <name>A0AAD2FZH0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001967">
        <property type="protein sequence ID" value="CAJ1958091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23609" checksum="8F7BC6FE63F42CD5" modified="2024-05-29" version="1">MSPAPKKAHGEAIKQIGGYLLGMADKGMFIKPDLRKSFEVYVDADFCGNWNKRYGHDPDTACLHHGYIIMYAGVAIIHKSQLQTKIALSSTKSKYTGLSCVLCEVLPLMNLLKEMKRHGIPVLDQRPKVHCRVFEDNSGALEMAKIHKWRPRTKHLCTKLHHFRSYVTRKEITIHPIDTEDQPADILTKPLAVELFIKHRKWLIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZP5</accession>
    <name>A0AAD2FZP5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001974">
        <property type="protein sequence ID" value="CAJ1958374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042293178" evidence="4">
        <location>
            <begin position="17"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="713"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="746"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1958374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="889" mass="93964" checksum="1A1EBB10835DF7C2" modified="2024-05-29" version="1">MWFLLSTFLLVAAIAAEEESKTPPYFFLIDGSDQLCLSGEEFKRCSIDSLFYVVGSPGTYEIHKRPIDGVLDEEEDGTCLAVKTCAEADLNKRSEAKLAKCSYCGSKDWNIVGDTDTGYILTHNDGKTCLVRESGGTAAMTGPCDVKNATAYTPLKLQFASAADIKTMSSHGARLIGAASDGDKGAIESMLKDGVDVNVRDWDDLTALIPAASSGQLDICKILVGAGIDVNAKDKDGITALMEASIMGHTHVVKYLIESGANVEEAAASEVTALWLSASEGRVDVMKELLENSADASNTRVDGISALMTASVGGHVDAVQLLLEHGADPIHTDRDGLTPLMNAAENGSVEIMKSLIDRVDDQSYVNMMSNTGFSALIIASAHGHLEAVEYLIASGSEIDAVYSNGVTALMYAAASGHASVMEALIGHGKASLDLKHTNGGTALLEAASSGMVEAIKVLVANGAEVDFVDDDGVTPLMAIASQGNAEAQSTILEALKKSKSSQDLVGHINLLSHSGGSSVMFAAAGGHVACAEELIKSGADVVAIARAQPGYEEKLAKMIEEGQVQEEEPHVDGVTALHVASQGGYIDMVNTLLEAGADVSHLDDSKRSALVMAVQGNHGEVASILVTAGSDPNTAYTDDDGVVHNLLFDAIVVEHEEFATLLIQHGCNIYHKDDKNVNTLLQASHRGLHRVVEALLEKHGKADTPFIDDASDDGITPLIAASSEGHGDCVQLLIAAGASLDMKDTDGTNSLMAAAARGHLDVVSKLLAAGAKINEQNVDGHTALMFAYNGKNQVETLWERYNQFVSESQADEENKDNVDDNGTGKTIREALDSHSSLVQLLLKNGADASLKDKEGHVAKDFDFHPDIDGEILDKESKAEEVRDKSEHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZX1</accession>
    <name>A0AAD2FZX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001967">
        <property type="protein sequence ID" value="CAJ1958097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="52492" checksum="4A2BFCF6232B070D" modified="2024-05-29" version="1">MWMSYKWMSCIQRSQIPQEIQRALIVNSVLAHRTQSEGGTHHPARFDTDSLTIGINNRCSFCISNKEYHFEDLQNTQHVIKGFGNQKTIDVMAGTLVWKWLDDDRKEHTFRIPNSFYVPSGKMRLLSPQHISQVLKKRGLETFIETTEGKLWYDNFYAYCAQCAKANQEDDLFEEDLEAPTAMEATMVSDDKHDNEKITTPTSHREEESEPSEDDPEPPMCETPMTFDLDMDKNKSSAPIHIEDNEEDTQKENHTAEFLKYHHKFNHCSPAKIQAMAKKGELPKYLATCNVPVCSACQFGKATRRPWRTKNKKNGRKAKKGTRPGQVKSTSVKETLVGKEAFERLAATYGIQVQHYHADNGTFAAIGWIDACYRKEQSISFAGVNAHHQNGRAEARIKHIQDMARTLLIHATKRWPKAINARLWPFAVRMANLSINATLWLADLKKLSRRDVFKFQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G038</accession>
    <name>A0AAD2G038_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G038"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="360"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1958870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="517" mass="55996" checksum="B634D79EB58618B2" modified="2024-05-29" version="1">MMSTDESSLQAAINESQKAVDAGCMPFGAVLANSKGEILAEAHNGSKAKKERGGAGDVTKHAEMELVRKISTTIDLDIRKTCTLYTSTEPCVMCAGAIYWSGVSRIVYGASAKQLETLSGPGGFDIPVETLYSMGNGIRPMECIGPLLSEHAMKVHRESGIWKGCPPPSADNSFQANADIETERSLFTSGIGSAAAAKSGDYSVPVIDLSQGSDDEIAERLWNAATTVGFFSLVGHGIPQSDIDAAFEASATFYSQEQAEKEAMSPFARQLNSGYEYMSQVRPSTGTADQKESMQITFREGVMDGRWPTTPGDFREVSERLASQCHKLANRLMDLLEPRACPNLKPGTLSKAHNLGVSDGQCTLRMLHYTPMDAETAKQLTTPDDNGRIYWRAGAHTDWDCLTLLFQRVGQAGLECMSNPQDATKDGARWTPIDPVEGGIAVNIGDMLARWSNGRLYSNLHRVRMPTPAECTPPSSRYSIAFFAQADKSVLIETDGAQEPITAGDYILSRIKSNFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0W4</accession>
    <name>A0AAD2G0W4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS17114</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0W4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649:SF13">
        <property type="entry name" value="ENGB-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649">
        <property type="entry name" value="MSS1/TRME-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0717">Septation</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042072310" description="EngB-type G domain-containing protein" evidence="11">
        <location>
            <begin position="27"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="EngB-type G" evidence="12">
        <location>
            <begin position="245"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1958284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="562" mass="61934" checksum="BA261B74A77AA717" modified="2024-05-29" version="1">MKHDHIIILFFLMMSSFQWKIKLADALLLTPPSSISYLQSTSSQEGGYQSNISSRRASPFGLQPLYAARRSSGPASAAGNKKKKAGPTGGGGGGGGPTKKKKKSSGPPTNKKGNPKKTRKTTKTEKKREKDQQMNPTLTSSSPPKQQQPKKQPHVPPPWQVVSKKDMARNVQAEKKRRKLAKEEGLHNVDTLQQEAELELELSQSFLSVQDKALVAWKRFKAQPRQDQVEFVGAYLNKQLPPTLGAPEVAFLGRSNVGKSSLLNRLVQSDQARVGKTPGATASVNLYGLYRGGGNSAANKKKAPKCLMGLVDLPGFGYAKLSKDNKEAVQMAAERYLAERKELMLGILLVDIRRVPSDDDKAVLAALYDSGVPIIVVATKVDKITSSPISTMEELPLELEKALYEIQQELGLPEGQPLCVSSTTGEGIKDLWRIIMEACEGGVAELRTKLLEQGAKARAEDEQEKSEFFDDGEDVVYNQGYDWIQDSASVMYEDEYGDSSYNVGYAASWDEEGGDGDANANFEDGDFDDYDDPGYDVMQEMPRKSLKEWRQQADEMERRGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G112</accession>
    <name>A0AAD2G112_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione gamma-glutamylcysteinyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS17698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.15" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001987">
        <property type="protein sequence ID" value="CAJ1959277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G112"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016756">
        <property type="term" value="F:glutathione gamma-glutamylcysteinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="entry name" value="Phytochelatin synthase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040409">
        <property type="entry name" value="PCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007719">
        <property type="entry name" value="PCS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05023">
        <property type="entry name" value="Phytochelatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51443">
        <property type="entry name" value="PCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0104">Cadmium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C83" evidence="5">
        <location>
            <begin position="78"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1959277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="331" mass="37781" checksum="C2ACD12086C00B77" modified="2024-05-29" version="1">MKRSRRSIMPFNRHDLSQATYCRGGLGLQIQASERRFLHTRDSDQVLGKAHLDRSFEMKCEVEEYPQGCSVLPPPPPEPVYSVHKRVLPTSLTAMSSPSGKRYLLEFLSDSETNSNCFWSLIEQFLNQSEPAYCGVTTLVMVLNAMSVDPGVRWRGGWRFYGNEDVLLDRCCFSAERVRRIGIDMEEFNLIESFRDDLRATMTDNASNRILVVSFSRSHLKQTGEGHFSPVAAYHDATDQALILDVARFKYPPYWVSIKDLYDAMIPIDRSTNSSRGWFLLNPPKKCNGNKEHSEARRPAELVPELGEEDACPIGRVKRRYCKANQDEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G115</accession>
    <name>A0AAD2G115_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G115"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041991061" evidence="3">
        <location>
            <begin position="22"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="659" mass="76233" checksum="ECCFAF2C1D9714AD" modified="2024-05-29" version="1">MSSRIIVVGAYLLCMVIPAWSFVNQFGVTRRAHNGVCFVPQPGQYKQRAFPPLFAGPGRPRKNPVQDDDDFEPDPAELEGLGIEAEMDVPDAVVSTPDDDEDEDDTVVAVNDDDDDDDDEDDIDEDIDIWEEDDDDDDVIVAEGDIELEEEWEEDGTASSYLKSEGGSDEEEWEEEEEIPLKDDPDDPNYTAQKKILEETLERRTEAEELANFDEVDFIMNKMPPEMAEAMEETDIQKQTNAKVAELMSEIDESEIEKMDYDEVMANTTSYLDEPYENEGEENIMGTGLSDDLLEKYDAALKEARATIAKEPWDKVNDKAQKQDWAQLSNQTIEEMDACLDEIGGSSYNCTNWLLYDLDFNVSNLILAAVKHNREAPILFQHWYPQLMTYERYQHARDREFDFNWDDVENADMEELERYYMGFGYSEIPDKAPAETGIISLDEMDEEEMKMAAFENWVKEVYNPEWDKKDFDDDSFQDEDNVFSHFYEAPQHPDLPAFDDALEDIAQWEAETDDDENTPEEYARMMGHSTKYKHIDDKEFEREFRGHLVVACAPEDEDLEIAEKITKRMDEEHGKKVHVETRVLAHAREEDCVFEVWLESYEIDLLHSKKRATGNDEDWEGPAVCDDAQIEYLVKEVGFLISDQARYSYRYETTDRDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G192</accession>
    <name>A0AAD2G192_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G192"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042108802" description="2Fe-2S ferredoxin-type domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="4">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1959399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="238" mass="26039" checksum="387BFC2287C755AE" modified="2024-05-29" version="1">MAMNYSTLTSAIVIALLAWCSTVNQNAVQALSPSSSFPAQTSQQRFTKSRLFSSTEKAGYEPKWKKKKTLAEEAGSADGLGFEKVGLTGRIPVVFEQGNNTKTSLAFAGQPLRDVASQAGQYIKYQCGKGECGTCECMVNGKWIRPCVATVPALADGEEFKIQLKAISAKSASSGTFFSIRSFIMGFWNNLLGMVGFVKMRRAAQKNWSDRQSYEGRVAQRTREIRAARLAKYANLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1H4</accession>
    <name>A0AAD2G1H4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS18053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1H4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="798"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="687"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="735"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="798"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1959634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="93369" checksum="ADFCFC7B27B01B47" modified="2024-05-29" version="1">MEDAESFLQTVGESSTQYEDSTVMMTMMATTQQPLPTGLSDVQEMVLAILPVPSAILSIFGSTCIIYMSLKSRFDKSWTPYTRLLIGMSICDIISSLTLAVAAFMRPQENGRVWAFGSEATCSAIGLLTQFSYSGLFYNSMLSLYFLLSTRFKLKNQMIAKRFEPLMHFLSLGFPIVTAVVGAIMGVYSTTTSELGCWVNDFPRGCIGEECLSITIGWYYFGMPFLISFAIIGLSNLNILIFVRQKTKKSPSSNSSGRGRGRDHSITAIGDLGESFHSKSGTTTAGGNTNPVSATDGSFCPTSPTTTLRDSSNPQDGSAARYSPASSFSFITMSGSFKRQTSWRSNNHNNNINKSRSSVSDYSDADVQRQQMKRLRLILSQALLFVASYIFTAGWLGLLRIIESMAETPEDELRMVHRIYPLMVINAIMAPLQGLFNMLVFIRPKYLKWRNEYPMEKRSWVFQRCIFGRSVRPTVRYMSPQQQQQQQQNKPARDDQTNQNDNHSDNELSWRKSRDTEDEEHEDGNDEKVVLDKKFHFPRSMASSLTASIGDFDHVLPEGQTDERWQASTSARNRWHSLHSSVVSSLEVISELSVSLFESHYPTPGASGDDDNDNDDEVDEMERTHTDDDDELDLEASLPRPPLLKTGSNHSEDRWSASSPPPTTRSRSSPIPITMLCSQRTDPNDSADDRWSTASPRSDRSPSSHRSPTLHRGNRSRGRNPTVRNADGTAGGGSVNSSDNRSDGRWSSSSARTSPLQQDSSFRTTHLEMPRRLVSEQQSEFNSSTAAETTILGGSIAESSVASASMTTDSNSSGEDTPLQPPTRRLSPGAETRSCIPDAPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1M5</accession>
    <name>A0AAD2G1M5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1M5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1957242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51489" checksum="81A1298FC12D9A85" modified="2024-05-29" version="1">MCCSGLGLWAKKDRDDFEEYAMDKLEAMLSENVTKLSKAEPMEAEESSKLARLIYNSMTTSGRVYHSMMHVFDISQTMNDPILILSALFHDVIYYQIDKTFDEAQIETLEGLLVPDSEPLKLKPSFDESLINSIIELYGLEPGSELPKSGTNEFLSAIIGVRLLQKWLSPEHLIQIATCIEATIPFRPVIDGKTPMDRLYDRLAAVANEKSESWLVETVRMAAATANCDLCSFDSNDRDFFLDSSWKLIPEGRPILLQEDCPLMEFLLECHALMGRSSFLQGAVPKIFQSFRQVPSDSEMEDKQRKTRDNLSLVIVYGEVRLLQMMCLVAFAKAVGEDPLSVPLRPYLGLEVLEPTKANPTLTSAERQIRHWLISGRRAGFDWDPASSSLGRYLFDTLGTKGISELVEVGKSHEKGSKEILNHLPKTMVEAIGSNLAKHFPEKEESYLQVSKKFGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2D7</accession>
    <name>A0AAD2G2D7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2D7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="217" mass="24932" checksum="F74914D37C2A3CD8" modified="2024-05-29" version="1">MYGKNRSNEDFCVFEIEANPSHWERLDSVSTAYKNVGWRYQIVKAAAFDKPGTMTFYHQGTDRRRSEFGFSIKSMGNTDNEHFSKVEVPTLRLADWIQTELLERQIPATPPSGTTYEKPIFGMKFDIEASELVVLPDMLMTGVMCKIDFMFGEYHTFLVPMEFENPNVTVKNEGQVRFLRNAMKGILGTARNCQTSFIIMDDEEYLHDGKPLPGDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G304</accession>
    <name>A0AAD2G304_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002079">
        <property type="protein sequence ID" value="CAJ1960901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G304"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="346" mass="38709" checksum="2A8A481D109DC653" modified="2024-05-29" version="1">MLYNLCDYCQFIYTVDRQHDPAFGTQANLAKINRYYSHLKNKSNEFEDISEVMPPKFDNKNTVELMESLEQWLKRNRGKGGTLLTYVICEHQNPDDNPTADPGLLMPSVEDEAIRRSLHREDQFVANNKAVWNMLYSVCHGTDAWPVIKGYKTTENGRQAYLDLVAHYQDLKNCGDGMSEHAKTEDTAQQTHRLTAISGTRALAAVDGGGQNSNRGRGRGRDRDNGGRDRGGHNRNRNQHGCGGGRGRGGSRSHNGTVWSDDGTTILNNGGYSQDTWSSFSDRDRRVVLQARERANSCLMSERDIAELNTLREQNRDRQQNEEPAPTPAPAPSSGNIGSGVRRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4S9</accession>
    <name>A0AAD2G4S9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS19924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4S9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041944275" description="RNI-like protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="556"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1962931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="70773" checksum="56D95D146FC80A5B" modified="2024-05-29" version="1">MTAKWGSISLGLLWLLASQAEATSARTSHKTKLDLSYLHRVKPDTLAEVLKNRLQKQSDIEIDLSSSLIGKDIKNIVSIFKDMKEDSMMDLTARSNNWSSRDGRLLLEAVLTRTEMPNSDESKTEAKLAPDEKEANATKIEEEEPPKSPTFPFHSLDLGWNNFGDEGTSESKKFLKALQKLVQESSNSPEPFVLRLDVCALSPAACRAIGKGMISRYDTETKTDNTEIKPMCLHLTKNEYIGDAGAAALSAAIRSIASKNTNTVVFDVLNLSACGIGDTGAEALAIALEDHPSSVKHLILSNNHITDEGAAILGRALANSKGTIGRLESLDLSHNKEIGDAGARELARTIEQNSVGKLILRSCHIRADGISAFATVLKNIGKRQTDRPRKIYIDLSGNPIGILRKVKKSGGYSASALKSKATATTAAYMNIIGKRVQRSLKDIGLTENQNTLESDDEEEDRMNGDGAFGSSEQKETKCGALAFADAFIDEDDAEEQTDRPANDKRTCSIALGLRHCSLDTRAAEALAAVIHEGKEKMGLNIQADVRMNNVLEDDMVMALQGDNKNLESDLVEMAERHLEALEQIREARKRAVEAARAAADRFRAETEMEGAWGSAMDMGDVYDVSYDEDVWDSDADYDDEEMDDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G586</accession>
    <name>A0AAD2G586_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G586"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042240115" description="VWFD domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="45977" checksum="FDF72F015A23ACA8" modified="2024-05-29" version="1">MMMMMMMKVVNLLPLVLVLVVVVVAAAAAADAATAPEAPADMTFFGEGACRAELDGYHDWAAAKDIYTVQACDLLCRTNDPNKGLRGFVLDAEFDHCICYFEDGLSPGEGGTCPPAYTRDLTPGNCKVTNNGKGPVDSYESHSEAYCYAYNAFPGSESNGDPHFRTWKNEHFEFHGQCDVVMTSVKNFVASANSNHETITLDLDIHLRTKMVRYWSYIEKAAIRIGNDILEVEGMPDFSLSYWINFEHKGELTNLAGFPVSINENNDKYTIHLDAIFPGQRIEIKTYKEFVGVKIIGATQASFGNAVGITGDYKTGHTYARDQSTILHDFNQLGQEWQVLPSDGRLFHAMAAPQFPEHCYLPEDPQGQRQRRLDESSITEDQAEVACSGLSDDFDRKGCVYDIVATQDLGMVGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7C6</accession>
    <name>A0AAD2G7C6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7C6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042081820" evidence="1">
        <location>
            <begin position="31"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="182" mass="20410" checksum="AAB7AB392447F59E" modified="2024-05-29" version="1">MHKAASTSILLTLAATALLCPADNFQQVQAFPISSASSLHRPLHHSMQLHSSPVDELELSPELESKWNQKNASRKKFGLNPMSLSEFMEVEAQVAQMSQQQELNLAAQQQTERQQRQQQQQQPSFMKNFAKGLLEDTCNSSFDCESPKVCCDLGFKKMCCSNGMLEVSLEYAMVPVPVDMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8K6</accession>
    <name>A0AAD2G8K6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002226">
        <property type="protein sequence ID" value="CAJ1965838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8K6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="259" mass="29337" checksum="46041F9EBDA6200B" modified="2024-05-29" version="1">MIKVSKDFNFLIFGRSLLLVSDPLFCKFHLLPDDLKLDKVPSDSLVADLLEKNTDAAVGYRSCGQGYQDYLTKDGTKVLQARTGQYQSFHYLVKRIMPSINCTNTKFDVRKQEETIGNIFTMSDKAFALMLLENYESRWRKQHEDPKSARLRGKEHAAICKEFKAKFTSSDDGLKLKSSGWSRQGIESYKEKLSSIGKLRRQSRTGAALEEYELWKMRSGADIYVKGTVPPTANERQIPIAEGSLAVLPEALESMFADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8T6</accession>
    <name>A0AAD2G8T6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002242">
        <property type="protein sequence ID" value="CAJ1965974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8T6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="138" mass="15373" checksum="1A49251AB3B7A7ED" modified="2024-05-29" version="1">MMNGTSINFLSKEQSTDGTATYGSEFVATQTCVKQIMDLQQTLRYLGVSIRGQSYMSGDNESVMNSSSQPEAKLHNQHVALSFHHVKEAVAANMLSFIHIDSALNPADILSKYWGHQQIWTLLPTLMFWSGDTADQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA64</accession>
    <name>A0AAD2GA64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UEV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS22587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="344"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1967047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45801" checksum="33BC4CB045E95804" modified="2024-05-29" version="1">MVHDPRITTLLSRLGGLYRDPARVDRDASSLLKSSLGVHLIPGIAPLVENNGDTSNCLVLQGTIAIVFRGTTYQLLVDIFLPPGYPRRPPVSYVRLAPNMYLKENHPHVGSDGMVYLPYTHEWNPRTHSLIEKIVAMSSVFSADPPVFSRSTPAPAPAPAPAPPPSPPPPLAYNAPMTNTYNPSGNYVSPSTSRQQDLESERYMQEQMDLIAAQEASEKEQAIEAAKRAEQNRLQQIAAQQQWEEKKTEDLRQRLNQKIQAHMVNLAHETKTSVQSDWQDEEKLKKSKDTIESQLKQLGTADEQLTAAIATIDAKTAEVKDFLEVNGESKEEEISVDDMCQPVSKLHAQMLELSAENAALTDALYFVDRAMYMGQMDCTTHLKSVRKLAKRQFLIRALLIKINKVVSKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBE4</accession>
    <name>A0AAD2GBE4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002336">
        <property type="protein sequence ID" value="CAJ1967574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBE4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="414" mass="45107" checksum="D3F97707C04F597D" modified="2024-05-29" version="1">MCISAEHQFVAKRRRDRASMAASSKAGSGPEQVLVSAKKDELLEACLRYDWDQVNHLCRTFSSVLIRKKDSEHTDLVRQQLIYQDAWGNTALHAACHYDPPCVILKQILKLAKATGVCHSLCTLPNANGAIPLVVCCTTGGASLTCLLLLLEEVDSKEQLCDSEGNSAIDGLLKRYLMLRKLPKFAKQMKPLQEINSVHSAGNSNSSVMIEMDDLTVAGFDKCWTKMELIMKAAWVLDFQSLEDWSPLHGAANMASQIPPELSELLVRCHANMVSTLVGGALPLHLAIGQRANGSTHHQDSCTASFVQHLIHADSSTVSHVNPKTGQLPLMRAIEAGFSWQCTADTATNDGILKQLWAAYPEALEEQDSQSGLYPALLAATTTTTTTKSDDNHADQVENIFSMLRLNPSIVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC21</accession>
    <name>A0AAD2GC21_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC21"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="796" mass="86968" checksum="89042EDB34F28D37" modified="2024-05-29" version="1">MSLATSGGMGAMGGAGAGGGLAMAHGGAMAQPMQGAPPPGGASIPMGMAPPSTSAAALGADLVDKQQQISLKQVRDLSHLPLVAIDLYSSQPHVASFPPKNKDPAAVPGAPSLIGKMKDKVLLQSSESSHKTFRKWLSKSKGYSDLQADVFAKADDKSAVAIESPQKWLGYRRLDDAPECLRSQVNLDKDSEPSAIAEEGTVGVGVSMANGTLDGSVPQGDDFDRVVAKVRLHASKKALTVLPEEAAQLVLNQAQHHVAKQHKVEDEDEIINFPCCVAVPAPYCTDSAMEAMLDATNGTGVLLQRSVCALAGALLPSAEEGKPNLLLEHILKVLQALQKEFQKQQLKNPNARFEEEQVVLLAGTTKDTVECTAIQISTPQRDQEFCIFGHFKVLCNVSYQHEKPESIITKCISELFDVMDAVAPEVDGPIAMVTYGTSEEQKAVADKWEKAKKSLEDWEDVPQFYSKPDSVAMGTSVLGAVSHGRLKTIVQVEGKKPKAALALNVQNVAPVAVGIQMNYHGGAKNKWQPVKTIFDFDRRVPAGPYDVDISAATGAVYQEQGSDLSDEALFKATTEMEASKYIPKREIAALDLRVQVVQKWTRDGVWKKIGDVQSPLVMTDKDGKKTACERIKLELSLSSVGLITHSLVGERETVVQATKSARNSKIRYYGSIILAIAFFGGFLVKSYWEERVFERDTRRLLAYYKHVVPGSMSDGDLYNARYVVYKYRNKKEKLWKNLEKKYGEPCLQEWEWPEEEETPAEEEEMNLDEGDEKKEEEATGEQQGKGEQESTEEPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC96</accession>
    <name>A0AAD2GC96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF15">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042093098" description="NAD-dependent epimerase/dehydratase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="349" mass="38212" checksum="E6FBE63FE3E4C1E5" modified="2024-05-29" version="1">MMMSNSNFQAATIWLMMLLTTSFLPNEYNWMVHGFSSSNFYNKVVESSSSSSSSFTRSRSKTSLFSSNSNNNNNLSDSQSKGKLLVLGGTGFLGQTICKRATLEGYAVTSISRRGKPSPTEASEATLGSYFRKVDYRQGDARQFDTIANILKEGGYVGVIHCIGLLFDDDSGLGTYNRFVSGSGSIPDGSSSYDDITRLTAFNAIDATLAYVKESKEGGRLDSSNFPFVFSSAAEAGWPDVSGGQQIEKFLAPDWLKRYLKAKREVEAKLNEASPPLRPVIVRPSLIYSLDRPASYVPVGAFFVGNRIGLPFVDRPVTVQSLANAMVRSISRTSVRGVQRYKEIDALNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDA7</accession>
    <name>A0AAD2GDA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002469">
        <property type="protein sequence ID" value="CAJ1970170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="278" mass="31665" checksum="4061AB15113E8957" modified="2024-05-29" version="1">MNFNRLRTHDPDVTIVVGNGDTVQEFECYQLILSMSSEVFDVMLSTAMKESHSSRIELPDKDPQDWPLFYSFIDPKTCRNAKIDTSNVMKLVPWFHQFQIEQLLTECDEIMEAYLCSKAPQNWRKLTEAQFEKLIKWTNFSGMYQLPLTLELSSGQIKSVLQGPYECVTAQSLKTLLPLVADNEIVWESIQEYLPADAAVVASGGPFSDRMALSQNPLLPYLLEAGLQRKRETGDSRFVTLETQIIDALQSKRTDHKDATVARCLKEVKGVIARYKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH33</accession>
    <name>A0AAD2JH33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS12259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43846:SF1">
        <property type="entry name" value="TRNA URIDINE(34) HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43846">
        <property type="entry name" value="UPF0176 PROTEIN YCEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="412"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1949761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="895" mass="99052" checksum="6460221F53126796" modified="2024-05-29" version="1">MMVMKPVRAFSSAPALCYSRQQSFAQTSRGRQSWRRSQLMTRLWDSSNQEQQQSRPLSNQELVERRLAVNQAKRESRQRSVQERLDRNMKFKRLLHNDSTTNSDQESPFVVPPLYAVKIWVDIDLRQEMRLSGREKRGRVFLESGSKGVQTISGLHQELYGFFSALRKNTFLLSASVPPITADGKVESLPPKEGEAWTIETDDDVIATFQKADEFFHESAVKLQRPCIQINVLKNPNAPPPPPPPAYLEGMADPKQSETMTMLSFYAFPPQGIEDPEAFAFDIKKKWKPFGALGRVYVAHEGVNAQMSVPTNVLDNFMACCKIVPELGEHMENGINIDPQPLTMEEFQSAGTPVNQKPAPPFRNLHVRVRSQIVADGLDKSLDWQSAGYDMPPMEWHQKIKEARETKDTGDDTSSPIVLDCRNDYETEVGIFEGAEPLGTENFRDSWDVLKDRLKDAPKDAPIMTYCTGGIRCVKVGAYLTQEMGFTNVSRLAGGIIAYDRTLTEKTEDEESMFKGTNFVFDGRMGREITDDTLGTCATCGTKTNLVSNCHNENCHKRMIQCADCRTNYHGTCSHACKTIVIKGQAKTEEGSTFSETASETSSKTFESIDDYSVGHSTPAPSVYAEMEHNTRAHMPTGAHMVSGATQGRILAQLASMTREGRILELGTFTGYATVCFLEGARNVGQITGVANGNIHSGPYVMSLERDVRAFNIAAAHVQAVGEKGLGVEAAELVCAIRNQEVPSVDGDFVSSSLDGIAGCDLLRVTDALATVEEIASGNGSLNPAPFDLVFVDADKTRLLDYVDACLSNDRLLNKGGFIVVDNVLWKGLVVEASNGSFSSVADSPDDDKNLVKKNRRARKLANQMHDFNSCIVKDDRVEVVLFPVRDGLSVIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH44</accession>
    <name>A0AAD2JH44_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1949159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="171" mass="19894" checksum="3E0122C6ED67E8D2" modified="2024-05-29" version="1">MVARTQKPQHHQLFNSSFDKIEFDFDDLKSPTPQKATKKSVRFERHDHVYEIPHIDDLSDEEIDDVWMHPDDFKAIRRECQAIILIIEHDSDLIEGAELRGLEHHTSKQKKQAQAIQKLLYDTVERLQTYGDQSSTDVSDMLACMCQKISKRPEAFARQTAAEDEEEAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHL4</accession>
    <name>A0AAD2JHL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS12243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF193">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="8">
        <location>
            <begin position="178"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="9">
        <location>
            <begin position="367"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="10">
        <location>
            <begin position="690"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="681"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1949729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="87387" checksum="718B3983E48AA12A" modified="2024-05-29" version="1">MKRRRTIQREDRYKGSIPVVATKNESRQRHTKANKLNTLLCRAMSSPTLPSEMTYSPRNQASFVVAFLSTILYLVLLIAGAREVWTYPVVIGGMICWILLEDEPNSLTTKRRSPVISRLYQCLTCSQRQSRATMFHKDIHHRLVKTTWIFIVVPCVTFFAIRAIKHIGSAHKKKANDFGFLAVVAMSYFLIPVSRQSVIVEALGIGSAHATRLHVWAGVLALFGGLTHGLYYCWLWFLHENKSLEEIVPFPSDTCWTWDYGSSCHKKFVNLLGFLCGTAFLILGATSLWVVRRRFFRVFYFCHIGSSFILMFALVMHYNKMILYLAPSLIYYLASNVPQCVEWISKWINGGNAIASFIEIPDSGGCVELSLRMPDQTSSSLCGRYIRLAVPSISAISHPFSSFVHVGYPGELKVIFRSHGPFTKTLSKKLSNASSVDSISYPSVVVNGVRSGTNQWKHAIQQDTLVIFAGGVGIVTYISLLSFMASLSKSHDELENAEETCRAIHKRRNVCVHWACRDEGLIDYVEEKYIDPLQEFFRARTSNIEIKLVIHHTSIAPREAMVGQKGKFGASESDFAKSQLPVASSFESGDSIPRNFTAGIPFGLIGMGGIAIIAYCYENIQEKHVAETRMIAIVAAILWSIAVATVVFVANRLSTCVPSKGLYSKLNKNAEIECTELGKSQSDKNSRPEIAGLDRSDELADSEESGEKSWMTVLHKEERPDLKVAIQEAAEDSIDGIQNLSVGVFVCGPTSLIDAVRTTANSLNEGRNSDSKIAVDVYDEIFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JII3</accession>
    <name>A0AAD2JII3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS14573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JII3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1953975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="197" mass="21828" checksum="6A15F8C49577B9EA" modified="2024-05-29" version="1">MTAVDAEQAMTIVGTIGGFAISLSLVPQVYLTYKTKCADDISYTYQFIYIFGASLVNAYAIYFQLYAVYIPCLLELCMIIILTIMKFMYPPRQDLIDCSKHSIMISHASKGSSTSISLQIIQRMIANGELTVGGDEVHGDGSKEFEKHMLRKSITLIKQMAIKGHHGIEAPTEKDQQTDLDATERAGNSADQKEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIS6</accession>
    <name>A0AAD2JIS6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIS6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="880" mass="94378" checksum="F7980604DC14ACC8" modified="2024-05-29" version="1">MQDADETKQESKRPESSRHRERGKQRKPSRRRSSDRNEAKPSRRRSADRDETKPSRRPSADRDEPDQERKGREASRDIVETNKESKPSAREEADREAKSRARKPSSTASKSPSKSRQQMDRDAKQRAKSSRSRSADSNDSLSKSARDRDSKAKHRVRPNTRASAPGVVQEYNDDEGDRRRRNKESGSSSRHTKAGAVSSSAGASPLCSPSKHTKAGAVPSSSSASRRMREKMDADSKPKEPEISLKPEPETTTLAGSLVEGDDAIVATAVDEEEVVQSKEAPLIIPPTTRPEEEPIMTSPPPKPFYCKGAFWIAALFIIAGAGVGIFFATQSNNETALPANGEAARPVPEETERPTTSPTFLPSAFPSSTPTETLIYEPPSEEDCVAVSNGDDLVGQENLNLQTFNIPMDVVLSTPVDSEIVRGALQERLQEMLMPELIGCASASRRVRGRQLVSSPYTIANGKVLVQVGQDTPCTRSTEPNCLHVSVKLDMYVRGSERPFDLVSLILQVLGPEGLLTSKLSLQSPFLQIFIVTVASGTITLAPSSTPTVVSSENPTLFPTESPSTDPTTAPVTFPTTEEPTGSPTVAPTVLSTPEPTILPTPVPTTSSPTFAPVVDATPLPTPTPTFAPTKGPTLSPSKTSSVSPSIAQSGMPSSSPSVAESAAPSTTPPTFGPTHEPTEVASNSPTLAPSSNPSVNEPFGNQFTSSTYVLYHTNDFSDPYEFGTREAAAAGCAAIGLDLCPMIAIENGDICAAGWMTDAVGYWISNPRPGCRTTPGFVEWVDREFAGAYCCGRPLYLPRDFSYIYDTREEARAACADEGLVLCTPQQIEGADYCAYGWLDTLWGLWSSGSNPVGCGPRGLNVGDNDGTAGAYCCASNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKR8</accession>
    <name>A0AAD2JKR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002011">
        <property type="protein sequence ID" value="CAJ1959616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="232" mass="26504" checksum="70733D7AAFBD0F01" modified="2024-05-29" version="1">MKDHQAHDKIKHAIFPKDPMQFREMVNGMRVFCCVVFGKTHPLTAVYKKFAKNVDSVAQKMGVSQQERALERFLFGIYSQIDRCFERLVRSGMNAEENLPNLGTYMETCYHGGSLPESNLFVVAKDSVGLGGTGDKTESQLKREKERAQKKSLSESVKNPDMNKEHRYTGRTTTELIKRTGEQPSKHANGKDLCLIWHTKGECKENCERKHSHCKLTDEEATAMKDYVNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM15</accession>
    <name>A0AAD2JM15_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002142">
        <property type="protein sequence ID" value="CAJ1963377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM15"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="86907" checksum="E4F7BA85BA96E4B8" modified="2024-05-29" version="1">MTHNLIPPFILRENGIQVNDTPKIHLADPSSDDHAIKFDEHLRIPMKLHGTFSYFVTRKPTVEQLNDVDPNHVYMLTPEEFDPHKSSYAQTEDHLVNYDGEVADAQNCSKLLISDIEDDPTMTVCAMSNMRMEEQTLVDESVLEERDADEGLLGQPFNVDLASISSIFCERTLSHHLSTRREVLSMMTSLGSTHAHEDDTDFLFEDMDSELDFEEMLSGDDLFTKIAAMADRKRVDLDEVMASATYAKPSKGVQAAHLAKIWKLDLPTAEQTLQATTQKRRHTDNPKMARSYGTNDRMLPYKRINQYFFMDTFFAAKNGGRSTRGNTCCQLFVTDKGYVYVVPMRSKKDVLSAVKQFAKEFGAPDVIICDAAGEQTSKELREFMHSIGTTLCVLEQGTPWTNRAELYVGLIKAAVRRDMRTSNCPLVFWDYCLERRATINNLTAKNLFQLHGKVPEETITGQAGDISNVAQFDYYEWCYAMDNEAGFPSNKEVLGRCLGPATGEGNKMCQWVLKPNGKVVSRRTVRPLTSGELHSDMELKKRDAFDKLIEARFGNTLGRQRKNVPLPEEEEEDEWATYQDDDEFSKPIPDNEDYVDIHGRLINQQPVYDLLLNAEIKMHTDGERISIGKVKQRVTTPEGKQMGTYDPNPALNTIMYEVEFDDGRVRDYGATTIAENLLTQVDDDGYSNTMFKAIVDYKKDPKVTVSEEKSYVMSKNGQRRTRKTTKGWKLMVLWNDGTQSWIDVSVLKESNPVDVAEFAKANHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNA6</accession>
    <name>A0AAD2JNA6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM-dependent methyltransferase TRM5/TYW2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS21806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000131">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 2/3/4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF31">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="5">
        <location>
            <begin position="312"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1966223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="588" mass="65625" checksum="13E51D2CCCB91081" modified="2024-05-29" version="1">MTTTKKKKQQDIRGDQVTVLCVLKRNAKSAKQALEGIHALHKKYRMIPSVNFSDCIAVPIILPVLFDEEEKQQGEDIRSTSEGEPSPENFAHAVVEEWKQTYEWDWIRHVDRQLCPYSTAVMGNQHHLNASNNSQGQFSDGLGQQDSNAGGALVEGLTSGQQALYHVIRYLAQEEREQQSKQQQGNNDISLKKDIQSLDMTICPKKLEVFGDDRTVVLPPTAFPISTVDQLLEAHVLQSIKVADDTNNESSSSCLKRLRQDFWKQLAAFYKSQRIARRGKVDPESKIRESGHRLIWPNSQGIPDETGPGAPGWIRVTEQGIGQSFDMCRVMFSRGNISEKIRFGKLVQPGERLLDMYAGIGYYTLPALVIGKAAHVVACEWNEHAIRALKFNVKDNKISEDRVTILKGDCRVVCQEHGLVNQFDRISLGLLPSAEGGWRTAIKALGPNGGWLHIHANVPVAEVNDWSLWMSRELWNLVQEERSSDEVNEQYIGNNEEDASGNKWIVVCHYVEKVKSFAPTVAHFVADVYVGRPSGLNSSSASCQDIDPSCTTAVVVQTDGTLIHCPETVKPPSCALSPDGVLSQEWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNM6</accession>
    <name>A0AAD2JNM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS22269</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF86">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041999721" description="Cation/H+ exchanger transmembrane domain-containing protein" evidence="12">
        <location>
            <begin position="20"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="50"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1966686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="923" mass="103248" checksum="310D2E873E0D96D1" modified="2024-05-29" version="1">MKRLRVAVVHALILQLTCATDEITDTHGHEAPEAPHAVLFPSLTLTLGVIVFYVLSRYAKALPYTAVMFLIGTIMGIATEFLGSYDHVGQSIRLWIGINSEVLLLVFLPGLLFRDAMSQNVHLFWHSLYQLLIFAFPMVLAGTVLTALVAYYIFPYNWPFNLAMAFGAILAATDPVAVAALLDEVGAPPRLKIHIAGESLLNDGAAIVFFSIFVGRYFYEDLDYIGGKDHSEDIDLSRGVAMFFQKALGGAAVGVFFGLGQLILLFILHRRVSREENIVQVTSVVGMAYLNFYTADYVWHTSGVISTVVAGLIVKLLGRGSINDLKLLEDFLCLLEHLLNTVLFVLGGIVWGAVVATGEKLGKWGGIDWAYLALLYIMLLVIRGFLFALVYPVTSRIGLKSDPKETLFQVYGGLRGALGIALAIALDNEVAALAGGRFETEAELHTTQAFVMVGGIAMMTLVINGITAGPLLRKLGLADSTDARSMIIKTLQVEFRSLAIDDFVRLLAQPRFYHTDFSFVKKHVPFLGDLTRTQFLDSARKYKNTHGLDSAPPFLKNILPDLENDKTPSRIEEEFSDEEVLADFDNYVRKKRLECQSTKAHRPIQNRRQSSNVRAMMGEDALSAKELRLLFVSIMRAQYEKQISRGELENEHFLAIALDQSLDFASHDIHKGRPLQDWKHLTELHDPMARLEARAMKTLMTLSCGSLNGKRSGKKILGCKVRSELLLIERAMAFMAAHEESQKLFHNENEDMDNKLSKPAKRVIQESLEQYASAQYALKHYDKQLVQKTASRKLCKILLNQTMYHVEKFVHMGALKESEAEHLIEEYLHSLHGLLESEEDVVHPEGVVQEFCPTQSVINPVIESSAQLVKFMERLSSAVDDKNRSAMVSVREGPERALYDSSAELLVETEEEDEDNRSRELKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPU6</accession>
    <name>A0AAD2JPU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multidrug and toxic compound extrusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002491">
        <property type="protein sequence ID" value="CAJ1970268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="53909" checksum="621F0370A3CE62EC" modified="2024-05-29" version="1">MSLAGEKKPLLTKAVVDSQDDTTVEHSQDVPSLKDEAWDILRLGVPIFIARLSWVGMKTTDTALLGHVSSKALSASALSDLWTMCTQVLLTGQVLGVFIGGAVGAGNPKLAGIYLQVSLVVLGSMSLIVFTAWNLTEQVWVAFGSDPEVAAMAGYYSRVLSFAIPGILVFGQVSQFFSAQRIMNPEVNSASFGLLMNLVLGLIFVLGWPITGFGGYGFEACPIVTATVTYLQLALIMIVYIKIQRLHETCWGGWNWAEITKVRIVAFCELYIPAALAYASDFWRTGVIGAVAAKLGEQEVAVFNTSYRIMWIALVLVGALSGASAINMSLRLGGMNPKGAKQAGYVGIVMATSMLLILSIAILFDSRLFGMIFTQDEEFLDMFEEARIPFTLTLFCMNLAVALERIPYSMGRTREVFAMGFVGSWVGQVPAVFLCTAYWRDDLVGLYTGMAIGYFLLVVLYGVIVYRSDWAKYAELAQQRSESSSSTTKKPVLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUG6</accession>
    <name>A0AAD2PUG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="118" mass="13314" checksum="005EDBC01D5D741C" modified="2024-05-29" version="1">MNSPKHASSLATPPSTPGTPHVDSASLASSKSPPAWNSRCRKTDQKSKNRTAIFNTMNLHQACKSSKFNVKVLSNTTGKPPRRLLRRHKQFTYWNQVSMLTDDCEEPESDRCERVYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUV3</accession>
    <name>A0AAD2PUV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS13687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="338"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1952729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="566" mass="62632" checksum="6F38D21AA80CAFE9" modified="2024-05-29" version="1">MPNKRRRLDKEESHIVIVGSGLAGLSAAISLEQAGFRNVSVYERDASFEQQKEGYGLTLTYNPKGPLASLGLLEKVANEDCPSRSHYLFRSDGSIMGYFGNAFSKTRGLGQRGNLRVPRKVLRRMLFQKLSATRVHWSHSLLDFAWKEDANQYTVRFQRKQKEGDVSQESGIAAVNADLLVAADGIRSAVLQNLGPTAHTKPMANPHVGLRPIGIRLILGIAEFTHPLLTERGFYTLDGKHRLFTMPYESNRFESTISNRIMWQLSFLTDGIDLEDKENSDVERKVLDPATLQEYVLGVCSKWHNPVEEMVQATPLEAVWGTDLMDRDPIQVQKLVKEQGAQRLVVVGDALHSMSPFKGQGANQALKDGPLLAHWLQAASIDSAVTSFWREIVQRTATVVAASRKAARELHSPAIMNDSHGFAGVKSDCKEGFLKILQEKRIGAELGSQLDKEVGTIILSMGIAGSEKETTVCETQQQKALHLATTGDIQGLRQLTLDKHSASIRTAKNDNGQSCLHLAAIGGHAIVCRWLLTEVECDIQSKDHEGKRPVDYSENGTPTVSVFRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUW4</accession>
    <name>A0AAD2PUW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS13505</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM163 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUW4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="12">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1952344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="245" mass="26649" checksum="F83F448127377585" modified="2024-05-29" version="1">MRFWSEPTGKDAFTLSWISCFITLAAAIVGLTFYNTAGSQLCLVFGLENCVDLFSSVVVVWRFFIPGDLTPELAEHLEKREERASMAISFILVLLGVFVMGGALDALLNGSEDETDMSLVLAISFISIFVFGLMTAFKFQYSKKLDSPSLHKDGLCSLLGTILSTALFVNTLIIESFPATWYLDPVVSLLCGLAAAVLGIQAIYLAKKSGLPVFSAQWWMLSQGSGTKETELEDTKNPNSLSGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVU0</accession>
    <name>A0AAD2PVU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001946">
        <property type="protein sequence ID" value="CAJ1957445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVU0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="218" mass="24703" checksum="69A1456862A65FD3" modified="2024-05-29" version="1">MKTSASNMSAHMDIKSRDREYTQMQMTNSTPLYFATDSRVHNIECVKALVPIANSTIIEQMEEAIDKYTVVQLSRKAFFVIWAVPPKGGVQCPAGFKGRPKFWTAHKLEVETCTGDRSRVVLICSCGFGHQYGIPCRHLLAVEGKYDINDFACCWRSDYVFYAYKEGHEAITQSFDELQKREHFGIVVKTLSLLDNILSTDRTTIFPSVFTKATCCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVZ5</accession>
    <name>A0AAD2PVZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS17194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="10">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="137"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1958474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="499" mass="56764" checksum="569ADAF9C4BF1CA0" modified="2024-05-29" version="1">MGVVNASSIKLVCFGQDTIIIDAAIHRFHGRLSRLPNYATDYKINPMNHTLQAIETIEVHISSDDVKLTHSVNESYTISINEYSSLVVIESENVFGALYALETLGQLLEFGWLDGEGDDAVYVIRNIPIGIEDFPRYEYRGLLIDTSRHFLPLDLILANLDAMLMNKINVLHWHMTDSQSFPYLIESMPELAVKGAYHPKMVYTRKDIQRVIHEAYLRGIRVIPEVDMPGHTQSIAASRPDLMSCCPHPSDPLDPTNPKVYDFIRDIYQDLRNVFVDDFVHVGGDEVDLSCWDNSKDIVHWRQQHNISSSVGLFELFETQLLEIVEKVGRTPIVWQEVFNLNLTLTATTIIDVWKGFDTKTMSDATRRGFKVILSGCWYLDHLTLDWQNFYSCNPSNFTGRTDLLLGGHASMWGEHVDASNFISRIYPRVSAMAERLWTGDISIAKENVRQRISDFRCRMVQQGFAAQPIGPGFCAHEVPYQSCKTGDRIPSTTLQLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW64</accession>
    <name>A0AAD2PW64_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001999">
        <property type="protein sequence ID" value="CAJ1959451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="140" mass="16869" checksum="9FF2F9C71D4FB61D" modified="2024-05-29" version="1" fragment="single">VDPDELWDDTYIPHKNEYKQSDENLRNEKIDQDEIDALLEEAEEFIENYDDEHTKNVKEQAEDRSVASIYEPLRRRNDDENSDQDPNPNDKYQNDEDLNEKIQEIEEDIQKDKEDVESLNDEEQIEETRETYEENDDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWI5</accession>
    <name>A0AAD2PWI5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="150" mass="16766" checksum="6D85C82AE7E9ABEA" modified="2024-05-29" version="1">MEYLDQTLEYVDHVAARVSFSAVLGLCLGTMYSTFRGLPMRSTALKIGGSFAMVGTVVFGLERIGYVAMKDLIEQEKRLLLTSHAFSGVAGGALNGYLFHKKPRQGIFYFVPVMMGIGSLELYIENKRAERIKELMLENNLESKEEIDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX24</accession>
    <name>A0AAD2PX24_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002185">
        <property type="protein sequence ID" value="CAJ1964447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="91" mass="9738" checksum="7B30C4E45CF3DC8E" modified="2024-05-29" version="1">MKDSIINPPEKDPNSIMTVADQGQGGLEEKNRSNSTTQSSIALTKDNPAITTPKRRSKRYPSKTAEDGAMKGRSLFPSDVAQGQDGSMAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXP1</accession>
    <name>A0AAD2PXP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rubredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS22151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00350">
        <property type="entry name" value="rubredoxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="8">
        <location>
            <begin position="374"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="9">
        <location>
            <begin position="1351"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="394"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="535"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="694"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="579"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1966568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1397" mass="154416" checksum="67CEE769C00B9E76" modified="2024-05-29" version="1">MKRALAQRAKESGMTNGVGPSSPKQPLSINTQDRSSEGQLSVSDLPEKSLSSTPTSRLEALKQSSNSVSSPRPSSSSPRPKKRARESIVKLEEEGEDDSNASSFYLRHQNRALASELRMLQYELSRLERERDYRRSQCTQAVQILNSLQATWTQMESALQCGHPSQKANSSIAAENDAPPSTGSGSSVELIGALLNSLAVLGTTPGKKGRIRGHGDEDLSEVKPHDFMDEDGTKQLDDLLRITDNVSERAQILQKWIWAVLDEVNSSTNERHIDLNKPGIEHDQKVANLNAMNSTLKEQIAELSTSRDEMSKSDKRVRRGLYRLAAGRVKLQEVLKEIVVTDEDKEAAAKWMEETPIVPAVQETTATSTASNNAADGENKTADTAAMAALSKKVDELQEIAKSRDAEIKKLLEQKEEQIRKINSLILNTKVDDAKSLSEQQIKQSDFYAELTAKLMTSERKAQSTNDKLGKLTKEWSQAMADTQATQKAMEDMQLKHLKKWKDFSDDTEMDEDGNGDNTGGPIGAEETITLQHKLKQAIENVRQAEITRQSLDEAVTMNQTLQSKLDEVKTKYSALQISRSSGNGSNSQSASASASTAGPSTPKQRHSSLGSSSTPSGEKSEGSEKHERDAAKLHKDYRKVRKELAAAIASKEAAKAKLATSERERHSLSLANSRLLKQAAERDDVNAKSLSTILHLKQLTDQMSKEKENLENQIKSSQQVALAARLAANARERVTEEFEKARKELGLQVKEWEEKFDSVSKDKEILEGKLAQQKAVMATALKDAEKSKKRCDELVSESTNLEDEKRQLKESLAVAKHEAAKASSAANHSSSLVDNSHGGMGSSSSGFTVDQLSTQVSVLKNRLVCPVCNVRDKTCILLRLSSMVHFNPYFFTILLVDPPSSLSFFLLYDLGIPLMDVSFQLSAFTKHPTKSVSQNTFNLTEKTMRVSVLALSLSLLAGNSDAFSPLHLSKVSSALRSGNNLHEFDYLLNEDASIFTQQQSRSRRRVQLNDDRATVFTSSIAPSADVAEELMAESMEGDVDPYAEMGLEQINAQAVKIQQEDQSMSQKMENRLKEMDFQDVCTTLILPSILAFAGLRWGFNKAAGRVEEKKDATLDSFASEMIYHDGDFEEMKLCYSDYSKKLMFLGPAKSNAMLKRYLETYAKKRTVSPQAISSLSYVFTLFKLSEEKAGQLLVSLCRDMGDTKLSSAGKLLFFGSRILKSPEGKAALQPVKDMIKASYREEAVAETMVETSQQAMAEAAYRSAVLAAGKDQETLTIGWEVLGLTKEVATRIFEDEAKEGFLSEREKMYGGQSQRYDSKGNKLDKEGKLTDAEAQKAAEEEAKQESEPASNVYECSECGFTLFIAKGREFKFYGEDFKCPECGAGKDKFKAKDLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE34</accession>
    <name>A0AAD2CE34_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000169">
        <property type="protein sequence ID" value="CAJ1931634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="32517" checksum="ED52136ADC27E004" modified="2024-05-29" version="1">MTRPARTSFQQEYNDDMTTNCQLHSTCDESCSQSSDTGVVVQSSISQRPSCLKPSSSSSRSAQAHPSIPRPLLAQYFNNKGVKALNYGDYRKATNLFVQAIKTFNDDGMDNHCSCQHCTVSSSVRYSLEQDSKPKIYDTSKDHYVHRRGIEVHPGAMGHKMGDALLQITTLNLAIAKHLICLECPLSDHRAQAKRYQKAASLYEMAFKWHVGDGNTDQNTVNISVFLIIVNNLSQIHRKANNQAKLFMCRRHLQSALMTLLTTQETEMYQVLHLDGFVCTAFVKTSCASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEI2</accession>
    <name>A0AAD2CEI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000058">
        <property type="protein sequence ID" value="CAJ1928663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1928663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="699" mass="80524" checksum="2FAF320D7A68F860" modified="2024-05-29" version="1">MTNTIINYINYITTIIVNQEYIIQAGISFFRLPVRMPLIVTQTVRETIAAGLVCATALLLLWYMALDLYRSYQALCEQRSCNRQQPPVSILRRPGGSSHRKKNRSWFGVFTRKPNRVRFAKIFRRTFVPNEQELQSRRECWGLIQWRIQLHDEVIPEIENTVRFVPHTPVSILRPSRKDWGSPKPTSSNRVQFAPKTRRRNFIPDEEELKSRRQLIHQIECKVKRRNAQRWKIDFKPTVLATIIEDPAEEDLSDIDSSLDTGFIDGNVDSETIAIALENHRQLLRTVIDDMLSNIPVPMDLDDDGNVEPNDMQDEASRLSLKRTATCSLVSSRPTKRRKLNSSTVPTSATEWAKRINERFTPLLPVIIEDPEEEDIIMSTFDLSLDAGLIDDNSDSDVASFAKGDDEVFFPMNDEEQDWDSLEYVDCNSLEHAPPTSTPTTAPVSILRPARKDWKSPRTTNRVSFTLINRRRNFMPDPEDIQSRKNRIRDIYSQIRYHEVCKCFEERVLPQLRSTVMAKRKAKRKTKRKAKREAKRKAKKKVYRKIDFKPTLPVITEDPEEEDKNHFHSSLDAGLIDEDIDSEGPSFALALENHHQTLPTTVLPGMLSNIPVPMDLDDDDNVEPNDMQDEAPQLSLKRTAAYCLVASRPTKRRKXXXXIVVGFLLIVMWIIACLSKRIVNVFACRTRSSPIYTLLIGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEN4</accession>
    <name>A0AAD2CEN4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS1695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000081">
        <property type="protein sequence ID" value="CAJ1929487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEN4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="13"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1929487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="360" mass="40755" checksum="47594EDE420D4FB5" modified="2024-05-29" version="1">MSSEADYIPKNILLTGGAGFIASHVAILLCKKYPNYNIVVYDRLDYCACLENLSELNDLPNFKFIKGDIATADLVAYVLREEEIDTILHFAAQTHVDNSFGNSFAFTHSNIYGTHVLLESAKACKTIKRFVHVSTDEVYGEGEDFETDPMSEEHVLEPTNPYAATKAGAEFLVKSYYRSFKLPCLITRGNNVYGPHQFPEKLIPKFTNQLMKGMKLTLHGDGTNTRNFLYVTDVANAFDVILHKGEPGHVYNIGGDNEVANVQVAKDLLKIFGLEKEEDWLTFVPDRKFNDLRYTINSSKLHALGWKEKMTWEEGLKTTVEWYKKYTSRYGNIDDALIAHPRMLNTSSSIDENIMMGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFJ2</accession>
    <name>A0AAD2CFJ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS1108</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="84"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1924859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="164" mass="16979" checksum="108518278B7505E8" modified="2024-05-29" version="1">MPSGKGSKLLRYVEHRLRVTLHDGRTIIGTFLAFDKHLNLVLSEAEEFRVWRKGGSGLIEERTQKRSLGLVLIRGENVVSLAVEGPPPPSAATKNAPPPPGGMPGGMARGRGMPMGGPPMGGMPPMGLGAAPVHGVGGMMPPPPPPPMGGMPPSGMGRGMPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFQ0</accession>
    <name>A0AAD2CFQ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="148" mass="16479" checksum="6CE88AE4727C746E" modified="2024-05-29" version="1">MEGYFSRLMREYSATDFVIIRDDAAISESQRSEFSASVASNDEDEAPQRPSFGNSQSVAKNSAPTLPSRKKSIDDLSLTLKRKGGSRMKRMSLNDEMLSHGIRNIGSNELPKLPSGNRGSSSSRHMLFDDIFRDIDAMLKETADILDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGY7</accession>
    <name>A0AAD2CGY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1,4-dihydroxy-2-naphthoate polyprenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS717</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1915367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042371">
        <property type="term" value="P:vitamin K biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929:SF0">
        <property type="entry name" value="UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1915367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36738" checksum="DB87E99311C4F430" modified="2024-05-29" version="1">MSPQPTAVSKRPPLWKVWLVASRPHTLTASLSPVLVGYSVGLATIKNVERASYLWLNCKWALFCMLIQLGTNLHNDYADFVKGADTDKRVGQARATQKGWLTPFQTAAAASGVLGLALLLGLGFISSVSGDPNHHVIMIGIVATSIFNAFAYTGGPWPLGYIGLSDLSIAYLGLGDIFVFLYFGLVATITPVFLYTANHDVDQLSTVMFRLLPYAIQVASLATNIIVVNNLRDRHTDISANKNTVAVRFGASFCRTEYSIMVAIAYLLVIYDWGIHSYSAARLFPLLSFRVARKELVAIYNKDGAALNPHVGGTAKVQFLFSVMLSLAMRIAMKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHC6</accession>
    <name>A0AAD2CHC6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000349">
        <property type="protein sequence ID" value="CAJ1934643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="134" mass="14457" checksum="5A56ED6C31BD0D2C" modified="2024-05-29" version="1">MGVAVVVDWNHSRCQGQAGDLLIVNVDCTRFKEELGVAGNHVVGGYQLIGVALSNVVHFRVPPFPPGHLLPCLGAISMAAHMLFGPGDVGNLEGLADGGEEIEVWGGWRQRPRREGLAKRSDPITRHPNAWFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHK3</accession>
    <name>A0AAD2CHK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000128">
        <property type="protein sequence ID" value="CAJ1931171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="98" mass="11275" checksum="EE7502261D4BAB09" modified="2024-05-29" version="1">MQFSNGQVKWIDKFIPMKAPDHWQNHTNYSMALDRDVLDIYDDADADDAFIMDAKYEATSGAEVADKQKHLTEDQRKLLAQALQNTDEIFDGQLRIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHS1</accession>
    <name>A0AAD2CHS1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHS1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="163"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="238"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1926247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="318" mass="36381" checksum="D23E06F8D0F8F904" modified="2024-05-29" version="1">MTSTNDSDKLRKHCKSSSDLLDEGLLSLMHCPPLPSFEMTASSFPYISSSTPAMCFEDPFDDPRMEPLPLLPWTSSDKQMPSTNDASGLESPFVQLNKSSEATLRQDLIDIMDPIINAGGPKRSCEAVFFDNDQGPLNAKRQRTSHLLQVSEEESTARFRPYQETQWQDQFQKLVQYKLKHGHCSVPHSCKEDPILARWVKRQRYQYKKFNDNNPTSTMTTRRIQVLESLGFVWKSHASAWEDKLNELKAFKQQRGHCNVPAHYPENAALSTWVKSQRRQYKLYMSGSSASTMTIDRLLQLQSVDFVFDASRCHSKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIU2</accession>
    <name>A0AAD2CIU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Magnesium-dependent phosphatase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIU2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26656" checksum="61098E0CE04D64E8" modified="2024-05-29" version="1">MSGIENHDNDNDNYTRKVQQQPKMIVFDLDGCLWKPEMYELSWYGKGSPFKSDGNNKGNLISASGDKVHLLGNVRTIFSELYSNNNNNNNKTNNRHPQESLSTAAPLVGISSRTDEPDWALELLEKFRLDDGVTPMAAVFGNHDDNNNKKNSNNKSLMQNERIEISYDSKTSHFQRLSAKTGIALEDMVFFDNERGNCVQVAKLGVTVAYVPNGVTSKLYQAALDAFPTTSGEVVNLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ05</accession>
    <name>A0AAD2CJ05_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="637" mass="74368" checksum="FBF6452DFBC04C8C" modified="2024-05-29" version="1">MADEFTEEYFVARIAELKEQITAALPTLESSQAFMAHDEQATAVWDSFQEYLGLRKKWEKTPKQPKDEKQKMNQLQHDALQAYLKLKEDTWPDRMDKGDAFFEELEPTLKELENAIMECSILTRTEPARLAEWCAEKGAHRDMWKDFMENKELQKKMITHGGAALGKYHKAVEIHADITQNFDNDAPNEVFDKIALAIALELAQPIGIFKHEDEQTVDPVERFWHYANGHTYNQLDKNFAEFDVWHMRNIVNSNATDKDATWMREMLKIWRPDQVRTPCSKWKYIWSQRTDTSNRRSMHEFDDMPSLVSAGGACGPQAFYSRALLRAWGQPAWGVRQPGHAAISRWYPEGCWGTELGHSWQNSHFPELRYCKQGHEREGNDFNEDARARLNISAEEYFYSVALLEALEDSLEGWLHPHIPADQYWRSLAISRRYRFATSPWREEPLEWKNKPKKWKRPLLPDTPEKWSSDEKMEFKRGQWVIPPCTCSFPDVAATSEVYHEFKDTEFPYYPGPDYRAAHLHVMMAYTGGWIIQLGNGIRVHTEYTMPDDFPEGSYELSLKFVNVHRLQTPLYFVITDPEGNESEKMLMDIPYTRGEYMIGEPLTVEMKPGSKFKFGRTEGCKFNLTVKEFYLKPVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ61</accession>
    <name>A0AAD2CJ61_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000119">
        <property type="protein sequence ID" value="CAJ1931047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="218" mass="24138" checksum="D7B3E5EBD39BF957" modified="2024-05-29" version="1">MQIPTQGGGTVTVPYSMNANGEIAFSGMQLSQQGFSGAQVRQGFDATQARTPQVVKTGYYDTSNVFHDAIKGKDENGNDIYLVPCPTGTTNVELQSDWHYASKSEDLPDLATEADRGMQFIQSRRIERNPFGLLDHVIMDSGCTNTTICNCELIHGLCQAEKELDMHTNVGSRVLDEEGFLGRFPPPVYYDEDGIANVLAMREMIAAGYRITMLWIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK22</accession>
    <name>A0AAD2CK22_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000592">
        <property type="protein sequence ID" value="CAJ1937053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="121" mass="13178" checksum="EC272F2AF6E6FEE3" modified="2024-05-29" version="1">MTCWELHHVWPQILSSVISILASKQYAKVSFVELSSVLIGTGNSGSSTVTNLALTPSSTSLTPFDFSKSLPPDTAVAQDKPQVNTSDLQQFRTPYTQWARRWPAWGPGMLGKTARVPLTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK59</accession>
    <name>A0AAD2CK59_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK59"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF30">
        <property type="entry name" value="OS06G0587000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="46816" checksum="A80D0B99543B31DC" modified="2024-05-29" version="1">MSKHQKTNLVTLRRRLILLIPKLGLESYEARVKEKKEELRIVNLRKKKKQLMIGGAVDLIFILLIIIIVLISTDCDGTRASGKSVGIGAASRSNMDRNNYKSHLVSAMKGETSMFDNLGRDTAHVRALNCLKKDHAAQAFVNSEELDLLLEQYVLTLFVFMSSAHEWFDFLLPKHDSYCGDLGIECNEDGRVTGLSIDSFDYTGAKAKIPTEIGFLTKLEYFKSVDFKGLIGTIPTEVGLLSALTLFTVGMAGFTGTIPTEIGQLREMSTFFLHELPHISGTVPTELGRLDKAWAISMSNMNLSGSIPSEIGKLTSVSWFRFENMDLSGSIPTEVGRMTELTSLKLSGLGLSGTIPSEIETLGLYTLNLDQNALTGSVPSLFQSDDGCRFNPPWSDSYDYRSCYCDLSHNSFSNNANGISVGCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKE3</accession>
    <name>A0AAD2CKE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphofructokinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS4690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000458">
        <property type="protein sequence ID" value="CAJ1935355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKE3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000002">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050929">
        <property type="entry name" value="PFKA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012004">
        <property type="entry name" value="PyroP-dep_PFK_TP0108"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005301">
        <property type="entry name" value="PRK06830.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45770">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000534">
        <property type="entry name" value="PPi_PFK_TP0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="11">
        <location>
            <begin position="126"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1935355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="524" mass="56529" checksum="F904FCCBF45C381D" modified="2024-05-29" version="1">MTATASTNSTSEASPLLPNIVSDIEYVNAVDGLTEDVKIPSPKHILWKVELVDRVFDDVNRATYPNPLSLKPNTPTSWFVDDDDLVAAKVNVAASDTDLDKGIKAEAYTLAGPRFDIAFDPKQCKAAVVTCGGLCPGLNTVVREIVMCLRRQYGVSTTYGIPSGYRGFKDPTTWIPLDEKVVRNFHNMGGSFLGSSRGGHDTKAIVDSLEKEGINLLFVTGGDGTVRGAALIADEVRNRGLEIAVAVIPKTIDNDIPLIDRTFGFESAVNAARQAIDVAVTEAEGFPYGLGIVKVMGRHSGFIAMHSTLGSRVVDLCLVPEVDFYLDGEGGIVDHLADRLLENGNAIVVVAEGAGQELMATMGSHGADEVDLSGNKLLDDVGPWLVKQLKPRLNEKLKGKTPYDDGVTCKYVDPSYMVRGIPPTTADNLFCTQLAHNAVHGAMAGMTSFLVGSVNTRECYLPIRLVANKQNVIDTAHQSLWEYVVFDTQQPSFAVENDCRDENDIITTASGGVIFRNSDDECSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKF8</accession>
    <name>A0AAD2CKF8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000650">
        <property type="protein sequence ID" value="CAJ1937463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKF8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="192" mass="21496" checksum="F69C6E2AEC02FE21" modified="2024-05-29" version="1">MSNSSYINALVRSLYDESQEHNDSTLSGSQPKIRSPNAFDSQSEPPSLFTRSANTWGGQFNPDHFQRNAFAMMSASPVNMENGAFAAMTAASHHKYEKNKKRSDRVNEKSYWVNGSHVDETITYNQYTIDTAVLAPTTGNQASDPTTVCELHQADKDNNGTQGGFLDEALHISMPRRSLASQRRHQRIVRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLL6</accession>
    <name>A0AAD2CLL6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLL6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="378" mass="41538" checksum="BD9B30CEB0A0BD47" modified="2024-05-29" version="1">MAYSIQFAALTALSFLVFLLTIILYTHLALDAHPTSDHASNRDVVSPHAIIGDKEEAIIEALWPEDGQDTTFFMSLNSCVDGCGPSSQDKSSSNNEQKKLKVGLLAPPGRMSRAFFSFCKQLAQQISKQPAGKGQESDTIHWIPTHHLPFTSNEYTHIIRFANVPLLLATGDALQTMVTTSQVPASDVSQIVWQDINETTKLLVSWHCQISNLVDEGTVPLVTISMEELEQDSYEQENMLMSFLTSSTTEENDMGGADGSGDGNIEPTFDESFIKETIGNIKPMLKQVNRVLLKEMNKGLVTLTKQTIKQSLHGVQGCPSEAGLWHPSRPLPRMLYSFLKTGKVEDDLALCDGHNAAMAICTMLEEARAQVLDITPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLY6</accession>
    <name>A0AAD2CLY6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000564">
        <property type="protein sequence ID" value="CAJ1936837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLY6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="417" mass="45908" checksum="E2374ABA45EAA529" modified="2024-05-29" version="1">MKANITNPPEKDPNLITTVADQGQGGLEAKTRSNSTTQSSIALTKDNPAITTPKRSSKRYPSETAEDGAMKGSLLFPSEVAQGQDVPTVNTRPNPTTPSSIDLTKDNLPDPTTSKSQRKQPPPSKTAKDGAVQGQSLVAYINETQGVTVLQALQEGLETGGVCSHNRPMRPAIIPHIVEESERLKREPTIAKAQSKFKKRLESTPPEHPTGAKAHDSPKNLHPSNEPMKFVEIVWHALTTAFPTKQGWNQNELLSYLHTTTILLYDVCAAHQTWPPTMGSNDAKSHEMNLKSTRTAPEHAQEGLEATTRSNSTTLLTVDLVKDNPYEHKFSMLYSIFVLFLSLEKIQQTKFLVHHFQILTIRVGAPICPLTGLARENCIQFFPWKRYPQNSSVSQEKSFHLVCTSPPTVGAPICPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM28</accession>
    <name>A0AAD2CM28_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1938987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM28"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="186" mass="21312" checksum="DCBC6B31F549BF9B" modified="2024-05-29" version="1">MDSLITFLQQLTPNRARKAWIIIDATVVVWSILLLVELLTTLTPKFRLEGERAYLVYNFGATLIWMVASGLHLLDHYIKYHHHGGGSESSTQAAGHETIPISSQLESRAEEQKDIRVLVLEWILAIYFLYASTNVYKQWQKPDEDVEVEIVDTLVNAGSYAYLVMRVWWLPKDDYTEVPSAESIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMI8</accession>
    <name>A0AAD2CMI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000824">
        <property type="protein sequence ID" value="CAJ1939668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042190937" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1939668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="45327" checksum="171413F08A3887E3" modified="2024-05-29" version="1">MFGTKKFLLLLLAVVLMVGSIDAAAVPERKLNSKKEETEATKASSSKSSKKSAAMHPTPPEHPMTEAPKPTDAPMTHPPMPSAAPEHPTTPAHPTAPAHPKGSKKGGDSSGKGSGKGGSGKGGSGKGGSGKGSKKSSNDDGKGKGGKGKGGKGKGSKKSSKKMGGDGDDGGVDPHAPTPAPNGSGSNATASPTSMDSFAVRPAPYALYYTFDNDSVGDATIDQFNELADLTRTFLDEYFTDKYGQTSIIELDDFLTFLTRSDATTRPAMAVYRSVARFNPRSIFYPPRSEIESEIELAFTEPASQLAYLKKLSDDLPTGNPFKTVASIRYGEPADSDSVAASSVSGFATAGIAAAAAGVVVLVAGLALLSRNRNGGDEDASVESFPPKAYKKSSAGSVAGETCAGTTWRSTVNEEELQDEPLDDAPRQHTSKLNAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMU4</accession>
    <name>A0AAD2CMU4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000087">
        <property type="protein sequence ID" value="CAJ1929555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="272" mass="31427" checksum="6442CA456D22122C" modified="2024-05-29" version="1">MSGQFQNTGRGSNGRNAGQGRSQQQGRGNGQYNGHKSGNGSQKEKKFHPLTRGNIPKFSFDEVKKTLVIKMSTMKMDHIDDMIQSVRTLSLFDIESVKPTLVLVTNDSDPDKEIKNEERRTNYLADRKDWKARKNAFDNNKRNVYGMIMKMCTDHMVDKLEREADFDNKLFNDPVELLMRIKKFMMTTVDTEWEYFGLWKTMSNLINCHQKEKENNASFCKRFEERAKALQALLGDDFLDKFTEKSQEYDLLGSNAERSQHKKGSTVPLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMX1</accession>
    <name>A0AAD2CMX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000094">
        <property type="protein sequence ID" value="CAJ1929819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="141" mass="16944" checksum="14AF77A4525A9A63" modified="2024-05-29" version="1">MGTSFGILQQVYINTAILASDTWLKRVWKELEALDMYVAFDSPALTLRYQHDTLLVNLFLKLEVDQDKLLWLNWCRMFLQVCTVSDITTADERFIRRAIWDGLRDDTVRSPYQWPRTVRPTRQHWELWQTLTLLELRLFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN33</accession>
    <name>A0AAD2CN33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1938062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="2">
        <location>
            <begin position="343"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="584" mass="66659" checksum="7EADF04695BDBF4D" modified="2024-05-29" version="1">MATNERAPKRTKVVTDNIELEQPEIGDRVYARYSGNGEWYWGVATNKFYQHNDLYYSIQYDDGDFDPEHKAANGIATENQAQLNNNNNNKRTNANIEQLQPEIGDRVYARFRNEEWYWGEVMDKFHKNDDHLYYSILYDDGDYVEEHNAEDGIATEEQYHWQEGERDRRQQVENTTTTTASSPTTSRTTSSRNRVIAVTPETAQSDTPTPDQPPSSSATTAARIQARRRRRQRRVVTPENAPSSSSDISGEASNSNTGNSERPTPDPAPSSSSRVAEVRREVLTTMGNDSRIKAEGGATTLSPEERDKRKKCMDQWIQANTDPRTGKGRYVFRRGCDKGCLTKILGGTGTEPWPISVNPPDYHGAPNPFIAKQEFYVAGNETWNFFSPRFPGDTGLVNTLAFSKRDRKHSTQKEFHMFVQCATTPHKRHWHGKDAKTGRLYIGVYRKVVDEDGDDDVETIVHMDDPDLDVTCRLAIARDNLRYYRKDYGADYTTTNQSFRLAKERAKQEAGEDDWMKYSKSKQDVLAMYQVLLLEGFTMTTVPIEFVRYDEKLYQALVDVGAVIDRKGQTGQVALTPEGLHHWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN68</accession>
    <name>A0AAD2CN68_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000735">
        <property type="protein sequence ID" value="CAJ1938558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN68"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="507" mass="56027" checksum="236F9F099A84A4D8" modified="2024-05-29" version="1">MQTFPPRTLDAILQVGRSALTTVKDLPLDTTKENLLLSNYFHTHIASECKNILLSQAHGFAYFDGADGTLRQVICAKQVGPNLHWASANDSYDAPTPVAFSLDALGSSVISIARDDLARECQARHLHDAQYSAHTALAPDSTDPPEDIHWPSGDGVFTKVKKFFPIYPGANIPPSLTLSAAPPANLESFHPQFRLWYEAMKYLHDHNESQSLHSHPHIFSADTIPTDRFPDSDLATHLTYSPSTVSAFAAEVPTYKALFEEFERHSALSTLASTNHVTTQEAPAAPLPAGAPFDSELFAQIMANALKGTNASTKEKDLAHTSASAKDSFSLIFGRVKPVIQLDGSTVNEFHPSVLTDDFVTFLEIGSIKEALRHLHDTFAHITDTLTTRNNYDRNVDFDIALFQHATVTALKTCSFGVRPLTMHPHEATSLLSLLAWFPPKKNDVRYTTFLSEGRDIIRQEAMVEDQSKQAAKKTDIFVHGDVSSVEALIKMLANFFALLCQRLYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQF4</accession>
    <name>A0AAD2CQF4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS8041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQF4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="263"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="9">
        <location>
            <begin position="357"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="361"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1942626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="503" mass="57094" checksum="6706EB47134F2AA4" modified="2024-05-29" version="1">MKRQLCITSELPEPRRRKRSARMHPASVVDISSLSPDVLHTILSFLVSESGCVDCESLKSASLVCKKWREVSLSRSLWSIPTNLQGNGVHKKDSINISLSIWDSSPYDGRIGGQSLMGFIKICHLESSKESDATRFLAKEKATGKDCILSIAKSKQKSSNMIKEVFRGHQVEQRHFLCPHLESFDRNVPRGIRLLNDRVVRWYENNTVHPVTPPATSNPRCDADFQRNDDSPMSQMFKLQSTMGEQNPSRQRLRSDSWAMIVDWIAEVAECFDLDDETIFRTMDLVDRVVTASKYTMKKQYYQLVAAACLQIASKCSSKEISGSNICMCSDNSFTVAVLARTEEYVLTKLGWKLAFPSSLDFLNQLRVILDLDKDSRMFQVMRYVSELALQTKLYVHFEPSMVAATAVVLSNYSLDNQELWSDELEGHTTYSLEDLAECTIAMSRLLQDVRHRYPNLIIIDQRYRKASRGCVAEISIPIIPSFASLVSYQQTRSRQNPDAVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS41</accession>
    <name>A0AAD2CS41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.50">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34631" checksum="D675E7137CCE4370" modified="2024-05-29" version="1">MTNLIPQHAEILTKAVELVQAFYLDHPEIKVSHGWKHVHAVWKHTQQALISYFHNDENINENDSRSSWSSSKISIEIQLASLLHDLDDRKYFPKPKITRLLPNKYSNAAALLEQLGIEVIEGLPVGGSGNDTLIKNYSDRISGHIILQMISWVSCSENGNLVPKLVQETGAYHLLIPRWADRLEAVGARGVVRCYQYNKEQQSAPLFSDQSPRPKNEQELWFLLQSNPNRLHDYMDRGGTSTDMISHYYDKLLPVAKPPKSIVRNQYLETQADLGAKHLVEVCVRFGKSGTVDKDYMDQLAMTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS88</accession>
    <name>A0AAD2CS88_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001266">
        <property type="protein sequence ID" value="CAJ1944876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="95" mass="11094" checksum="95C5D784C260CAF1" modified="2024-05-29" version="1">MMQIKAKFDTDEGLNFIQQYYINQGLKKFGDDGKDAVDKELRQMLLRDCFTPKFVKDMFASERKKAQSAMMLLAEKQFQKTIKGRLVYQGNGTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSF8</accession>
    <name>A0AAD2CSF8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001325">
        <property type="protein sequence ID" value="CAJ1945062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSF8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="145" mass="16344" checksum="3E39095F53B281F2" modified="2024-05-29" version="1">MPQLQLPLFKLSLAIKWNVLPCQEQGWRMNQDWILGGGMLLAQSCLFGRDDWESQQSFVDLATLFSTPLDNSGYSDSVFLNPMALALFEDPAWYQSNYTFVYSKSTFSLGAGHYFVEEICLNRQENENNGGMVAGVGTEIPNRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTW0</accession>
    <name>A0AAD2CTW0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001533">
        <property type="protein sequence ID" value="CAJ1945814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTW0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="129" mass="13764" checksum="4A803E66C0AC7EED" modified="2024-05-29" version="1" fragment="single">MVLSLSRYDEDDPRSVYKAKKLKASVQIKSFKSAHTGIIKSDPDGKSIADLQSSPIASTANSSYRSHTGHGRSSVSPIVQVAPESTTPASTTPASSSSTSSHTNDPNYYGYEPDAREDRSNTATTRSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV34</accession>
    <name>A0AAD2CV34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS10124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000093">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="4">
        <location>
            <begin position="142"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1945982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="38128" checksum="4CE90B0353853C9D" modified="2024-05-29" version="1">MIVQEQTSYRYESYFPSNLSPQEVDQQHRLNVSWREKICQWSYNVVDHFDLPREVVAVSLSLFDRYLATRHNQCTGNMALLTSLTTLHISIKIHSEKTVKLSTLASLSRGQFGPSDIEQMEWKIFEALDWKLHPPSLFAFISHFLMVFPSEVSHSVRKELFEVAIYIAELSVCDSSYVRYPWSTVAMACILNVMEDLSYIRLPLAARQAFWNEITTKTSFRETSRLHSARQRLRSLFNSTVNSMTSMDQTVTSSPTSTTADPMQLDESASMKYGDHHHNYAKGDRYRYSPSPNVRSTIGSSPMQYSTTTTTTSIASHPNRSMLSSSPIVTRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZV6</accession>
    <name>A0AAD2CZV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001247">
        <property type="protein sequence ID" value="CAJ1944761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="28714" checksum="79C8DA4A2A0A2B93" modified="2024-05-29" version="1">MANALKGANASTKEKDLARTSASAKDSFSLIFGRVKPVIQLDGSTVNEFHPSVLTDDFVTFLEIGSIKEALRHLHDTFAHITDTLTTRNNYDRNVNFDIALFQHATVTALKTCSFGVRPLTMHPHKATSLLSLLAWLPPNKNDVRYTTFLSEGRDIIRQEAMEEDKSKQAAKKTDIFVHGDISSVKALIKMLANFFAFVKYCVEDFTFDDPPLIVTLLEDFMNALHTPAAKDWIRYNAVVPHLPLCGSRQKQNDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEU7</accession>
    <name>A0AAD2FEU7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000291">
        <property type="protein sequence ID" value="CAJ1933640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEU7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1933640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="580" mass="63991" checksum="2A9530BAD8E45479" modified="2024-05-29" version="1">MNGHNDPYGQSHSSQNDRQRHNSGSDQQVIDLSSPPSLLRRSQSESAAAAARYGRQAQHIVAQYQQQRGGPPDIIHYVDDSPATAARSGTPPRPPRLTPDQRSQSMSTPTSRLNRYSFPDLAASSAATPSPSKIPPQNSWSHRPSSTRSADHLIRRTGSADTSSSSSYVIKFQTLRLEHGKLLESHQALQQDNLTLQSHSQDLKTKTVQLEARLLESMQARSAREQKFQDEMKRQRGSMHSLFTELADSKRQVELLKQQLQETVSKLALQQALTANIAFQQEQEELEYQMELEQARKQQQHLVGEGAAEMMIPASESGDYSEHDDARSNYSNNTRDSGFSRLGNFFNRRKVPAGGSGGPMMMNTIHTTSTGTRTPSSPVVPSTTLEFGQFQSYEESKNDLVEQIHYHGGGADVHNLFDLDTTTTATSTEDSSNHNGLSSSTSEDYLKTVATTKPPQPQVATATKPLRRGKQKQPEMNYGQTSAGMPPAAPMSRLDRIRQKRRNLESMFLKNGAGSATSGLTANSSLSSTSSSSNASSSIIMARGTTNFRARSNNNNNNSPNRNVVNRNVVNLMNHRRHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF06</accession>
    <name>A0AAD2FF06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1898547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="8">
        <location>
            <begin position="228"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1898547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="387" mass="43922" checksum="5FA6308C80C17AC8" modified="2024-05-29" version="1">MFSNAQRILVRRAALRNGRATHTVLRERPVVFSVRTFAASEKSTKEDDGSDETSKKTEDGGSFKDTIRKMREGGEGKGKEDDMEEQFDGFLRSAAGTWSSFKEEVSQTWAELLRAGEAKSINKRINHPEDTAEGEAEYTGPVEIMVIDESEHLTAWERMQKRLSEAPIISDMLARGDEIYEKSGARKMKEKADHLKEDAQEAWETSQNPWVYRASSIYDTLTADSPESVAVAELRELDPEFTLDGWKRDVVEHTLPKIMEWLLKGKTNQLKPWLGEGVFKRIAAENKARQQEGVQIDTTVLGIMNSEILACERDEVNKGSPIILLHFMCQQINCVRKKKDGEIVEGSEDDIKANSYVAAFQREYNEAEGELQWKIVDFRFNGAIAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF51</accession>
    <name>A0AAD2FF51_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF51"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="615"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="703"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="941"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="975" mass="107443" checksum="29791DF86DDD46E6" modified="2024-05-29" version="1">MSDHSTRSSLSVDMATANKATAASIDNMNHSIDPETCPQIQRLEFADYLDVQTRLMLVPRIEEEGIGAVISTFVPSVSSQSANEDDNDKNRSEGSNENRDDSETSSDLTGLVLIRMESSPISTQQNDDWTDMDFTSILANIRQTTSFPIVLVFTPGPCDDGAVGTIEVQQGQNNEPAEVNSDHKNAGDHEEQNPQQHQQKDSINSLLSWGQRMRAQASVAANTAATAVATAAKERIQNTTQQTTHHPSRDEPKPCDVFYQTSIGVLIPANTLKEPKISTTSLLLVRASATKALSTKKGHQFQWYRSSKKAVVSVPDDLNSVTSTVSGKNDGCGDVEWIPLEGATSSAFQPNATLVGRRLRCHVTLEGDGNSSVDSDDSSDDDDDLNSIGSTADIAIDLEHPIVADPSIFNGARQALSRGAKFGGISGRGNAQSHRFSIDISIGVGKLHHKQVAMSAVTIHTVSGDETIKLTDEPIKQVTATADASNSNDLDLLFPVVPEEGSMLEAVLTDGKLLLKASNRITRESLLMALGIANYQGRPGKLGCKTLLFDDDVQSQQPRSFMDDDSLSSTDCTTPRNGSQLLSPDKSIASSLPLQSPAATITESVSGESPEKEMVSSLTNELEMLRAKLARKDKVVSELQRQVAKSEDVYQQMKTSLVSCQDELRQSRSACQNMQHAVQSAETKIESFESIMSETKSAHLENVKSLEGHMSKQSEKIAELEKNNKSLQNEKAVLSAAVEARESKLLRMGELRSSLSEMSEQVAKYHALQSELDQSNNRCVNFEKSLKEAKENEIKSQADMQSALEKIDKLTICVKQEEEKFASLKKEMEPLQKKNQQLKAERNSFKQKNDSLTKEIARICRNGRSVNEIDKMLSDHESLLEEIDLLRKQKKKALEDAHQYRMAYEQAKAAQERSGLDTQTTSILERNVELERLIAEMTEYVNAKEMQLETMKQVNEHLQQEIHSLAQANFNRNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFL9</accession>
    <name>A0AAD2FFL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000435">
        <property type="protein sequence ID" value="CAJ1934986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFL9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052514">
        <property type="entry name" value="SAM-dependent_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203">
        <property type="entry name" value="METHYLTRANSFERASE, FKBM FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203:SF15">
        <property type="entry name" value="SLL1173 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="174"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="424" mass="48606" checksum="7CEA5F673A225830" modified="2024-05-29" version="1">MLFPKPPLCTTDQLMKVRHHMPPETCVRQHVRKISFFQVCSLTAATKCPNATWLEDYYLDLQREHYNGHIDQSSQGKQLWSSSSSSSSLNNLQHESQQFLGISIGCNKGFDAINTLRMGTYDADIDKAKWKQAMTSDGSESLHLSVCNQDSAADVFPILNDDHHASNNSSKMILRPRGEMHCIEPMPQTYHKLQQSAETLGYTDKGLVVTHGAVSRNSGEMPFRSGGKAAGVENIGLGDCRGGSKQDCEMVKVYSLLEFVERKVQAPSSQNINVLSIDVEGFDGDVLLGATSKVLERVEYLEFEYNWMGSWKRQHLYDIIELLDEQASMVCYWAGRDRLWRITECWMSYYDVHSWSNVACANRRLVPELAAKMEETFQRTLEDETQWFKHPNIPKKLGFWQRKYKDHVLLSLEEDKLRQKYIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGA6</accession>
    <name>A0AAD2FGA6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase-like protein LARGE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS5065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF52">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN GNT13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1936185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="63879" checksum="F1EDC06E911D4758" modified="2024-05-29" version="1">MRRKTLWYKLFCSSPWKRTLSFFIISYLAFFHGLIPLGEWLMQVGSWISPGGNHGSNTNWLQYDSTLEISPLRNEQLERLQVESERSRLQFGSPQRNRLRLDILEEIVPKWYHRNDKVDSASRNDEAVNGKGESPTAPKKEKARSHQEKDELIEKSLPKERASKLHNISQDYSSKRSSMDPNKKDERRLQQVKMANDSTYPFRKLDNMDSYAAKYTSCSSETTVEVKTTLVLQTSISRLWILNESCSRWKDPIIAVVFVPTDEKVPEATLHCSNVQLIFYEATEEESAKKAYPVNRLRNIGLDAVTTSHVLVVDIDFLPSQDLDGRIREVLENQIELQEDRQALVVPAFERIPPKPCTTEESCTKYLQSDDSFLPHSFEDLQGCVKRRECQPFQSSVSWDSHSSTQSKEWIQRSWYNGEEQNMLRSVECFHSARYEPYVVLQWCPTSPSPGEKSVPKAPYYDERFHGYGKNKIELVSHLRKTGYRFLILPEGFIIHNPHPESAIKEEWIDFGGSDLHASMDKLYAKFTAQLDHKYKEFHDTMTKICKRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI68</accession>
    <name>A0AAD2FI68_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000291">
        <property type="protein sequence ID" value="CAJ1933642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI68"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF1">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042204947" evidence="1">
        <location>
            <begin position="22"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="406" mass="45698" checksum="5BDAAC56A47F269D" modified="2024-05-29" version="1">MNKTKCLVILCELIADTTVYSCLATSGISVLEELILVDAEYLGVDAATALSEYLMGTTSLKRLDLMGDDFPDARVCTALVEGLERNRSLEKFQIDVNGFGNDGLFRKLLRALQNQPNLRSLYLSEQHNMSEQAMEVLREWFSSADCRLEELSFLSVQHLPAFNSSRSGGKAFENKTLHRLLLVDSNVSSNELGGLCNGFPNLKELTLMYNNICDLSPLESILSKEDCQIQELYLNNNDISYEAIMKFSGKIKEMKSLRRLGLQQNPFLDEIALQPLLNRLNVSKSLEQIRMNKRNQIECGADAIELCHTLNVNRGGRHGIEVESANRNISAALWPRILHRASSMNYFFNLLNGENSDRKPLDKSPRAAVVYSLLRDNAYIFYHCGKGEDENVPSSPAPKKHKVDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIB2</accession>
    <name>A0AAD2FIB2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIB2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042121751" evidence="3">
        <location>
            <begin position="23"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="339" mass="36041" checksum="73B6869805A5C30F" modified="2024-05-29" version="1">MKLQQYCLAPLLCALSANMSMASPAPFEVKLDEPDNRDYGEFGRSVNKPKKRRVAKHEPTEADHMYRELIEDVQLLDFASMSMSMGMSLDDNVDAQVDTTPAPSASVPTAAPTAPQTSAPTEAAVATSASCDGQPQVLINIPLEVDTATDDTEIETLIAEALMETLADEYNFCGSRRRLEDGSIVVEDFQLGTITVTKDANETCPPLDPSTSCHVANAAIVVSGETDGSAAKLRNSLGFLFENDVKFIEELPLSGVIEVRLKEGGEESEANSASAFGNAAQPTRSAVVAILSTAGISIVAAIILRARRKEANMAAHDKYCDESDSEGGTLPINNASGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIC3</accession>
    <name>A0AAD2FIC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000324">
        <property type="protein sequence ID" value="CAJ1934015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="73"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="365" mass="40435" checksum="DCEC5771F94B5E74" modified="2024-05-29" version="1">MNGTAVDDPFACFEGDSDDDENDKDDESKCNPPEASVAPSIATDQGRRLVDEANARLDAAVAVKDGLLPVTSASFEVFDTPNDAGKGLRALKVFECGDEILREYAAMRVPNHQAAESLEEAEQLHERAVQSTFNNLHQCTRIAIMQLSSCDEMKDGYERDMVSPLGVYQTNSFILGDEKCGGLFLTTARMNHSCRPSATHIWRPDLQKTVVFATRRIEIGEEICTTYGPSECLDTQGRRDYLRERFSFECGCEMCEEGNRFGGDDRMIEISSLQEDISMLAQTGDPQAAIAAVERCLSLLKEQGISIGPYMKPILYYGYQIAIDGLKDIDLAESYLSKELVLIQQCEGPTSPKALQIQAMLDDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJZ0</accession>
    <name>A0AAD2FJZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS5272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="518"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1936599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1159" mass="130586" checksum="8138AAD694548DA2" modified="2024-05-29" version="1">MDTSTRSRFSSIRKFDSDLTSDFDVSFSVEPSNDSNSDSRDEVQEVRQLVQKEENDASHWRYAITLLLVLVASVVSGLTWHFLREEESKAFETAVDQFSKALADSTYQQQEDIREAYNSFADTLSNWVATAENVSWPFVTLPLFESYARHALKISGTEVFAVFPLVSHENREAWVNYTIANYEDMVQQAHMIGKGNLESLVGGGFHPYIARPSPNGFIEDIERDQYFPMWHFSPPPFTHGAINWNVQSVDAFRDVVDALLLLKNETVISPVRPYTTAGMSMSQEEHEAMHSTLKDSSTEHPHSFVYTAVHEDANDRQSPIVAVVSAGSAWDASLYNLLPDGVMGMKAVIQNNCGQQFTYEINGPEAIFLGEGDLHEPEYNEYKLTADLSFHTHPDFETTPGHCQFQMHIYPDSTFADLYFTWLPTIYACAVGASFLFVFWAFYVYNAFVNTRKEKLIGMAARSNAVISSLFPGKIRDQILGEETSNSNPRSFEELLGASATPGINTSAPLADYFATATVMFADICGFTAWSSVREPSQVFTLLEAVYGSFDKICKHTKVFKVETVGDCYVAATGIPKYHRDHAVLMIQFAHQISKEMTKMTQMLETTLGPDTSDLLLRIGIHTGPVTAGVIRGDKARFQLFGDTMNVASRIESNGIAGRIHISHETAECIRKCGKGHWLVKREDGSVVAKGKGDIQTYWIGKAVENSKPDSTTKYDTASESAESETFEEFGVTEQLCSTDGREDRLVNWNVTVFLDILKHIVARRNAYKKGGFTRKFELRGDDPEVLMSLGMRNYKPINGVREIIALPEFNDVAEGLKEDLQHVDIPKDVIEELRNYISTIAGLYRSNPFHNFEHASHVTMSVIKLLSRIKAPSDLEALEGRESSGDMSPDIHAQMHDHTYGITSDPLTQFACAFAALVHDVDHEGVPNTQLVKERAGVALVYDARSVAEQNSLVLAWNLLMSNRFAKLRSCICATATELTRFRELAINGVMATDIVDKELKQLRNNRWDKAFKRDNSSLNEGFDGDYAEQDRESINRKATIVIEHLIQASDVSHTMQHWHVYRKWNENLFRETYKAWQEGRCDSDPSINWYKGEIGFFDFYIIPLAKKLESCGVFGKSSDEFLNYAKSNREEWGKRGELIVQELVANAKNEFGEKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK11</accession>
    <name>A0AAD2FK11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001480">
        <property type="protein sequence ID" value="CAJ1945732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK11"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="535" mass="61300" checksum="7042EE94CC9D909F" modified="2024-05-29" version="1">MDKPLYSMFTGADAEGNSHALLKGRLPITDGIDSYTQSFLEQCHFHQGHSMIPMEVSPDDHTYFWSHNPENKGSEPHGLHNGHYKAGIYSPTVAQCDALFRHTLLITGFIPDNWRHLMNCAIEKKPGDFWLTKMRTIQLMNSESQANYKKLGRLAMAYGEDHHLLVDAQCRSGKHHQEIDLALSKRLVWDLLILQRRSAGWISNDAKSCFDWVVHWVAVIAMMRMAITWNVLRMMFDTLAMSTHQVQTGFGDSEESFHPPSIVPFQGCGVLLLTRLQLETLKERVRKYSISSHFSPQQLIDNVNINYKSDMVAELGQYVHAIATDSNNSMEPQSIEAIYIEPTKGQLTGHGELNLNTKKMISRPKVVILPVTDQVIQRVEAWAAAKGVTSMKFFDKKRDLETFQDGDQIAGVDDTEQGYLEEGFDQDYEPEDEDERDFNLRGQFNDMKMKMNVISIYVDNSMISMTPKEKSSWQMQTMMSMICQNSLSDSVEMMTMNQTTIRVMKATKRKNLMWPIWITIKKMSIEEPMILGARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK96</accession>
    <name>A0AAD2FK96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000635">
        <property type="protein sequence ID" value="CAJ1937339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45125">
        <property type="entry name" value="F21J9.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45125:SF3">
        <property type="entry name" value="NO-APICAL-MERISTEM-ASSOCIATED CARBOXY-TERMINAL DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26523" checksum="18481599663AF784" modified="2024-05-29" version="1">MVRGVPNYSQEEDKALCAAFVNCSENPIKGSDQRREDFWKDIENKFKMKMEEDPAPALPYWSHNSLMKRFQRIKGAIDEWIGYELQCERNKPSGLSQEDLDKRIAEMWRIKHKNEEFKFCHCVPELKIHCRFNVSHQSSESDGTPSPGSKHSAFAVVCTNSKRPIGSKAAKRMDEQTRSRDRDNAKRMKTFEEILKKQDRLTSAMEYNELDFGSGGHQTSDRLVVVQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKL7</accession>
    <name>A0AAD2FKL7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001669">
        <property type="protein sequence ID" value="CAJ1946438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKL7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="19410" checksum="E1801AC3640C0479" modified="2024-05-29" version="1">MYTNRPLYGGAITCDIKTDWKDVSDIRQVPDHQECYQEIDGAVLVVEILERQKVSDAGAAAFFFKDLAESNGSTENKFEPKDIPAGTNLMNCSLCAGVGIQKVAMGKDHDMAGNPRQQEVRLVQVEMCVFRLANVGTDLLVTISKPISDLSNKNSSGSEPFHKAISSLQVRNWGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL16</accession>
    <name>A0AAD2FL16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS6411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47764:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47764">
        <property type="entry name" value="UBIQUITIN-LIKE-SPECIFIC PROTEASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="513"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="620"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="700"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="947"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="716"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1249"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1939071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1390" mass="156470" checksum="5AC1B5213152F9D4" modified="2024-05-29" version="1">MDRANMPRPKSSRGRHDRGNQNGSRSNNRRRTQDDSMDFEDDRQPTHQSSRHERKKSPLNGMNPLQFTKSEYAHEALVAPAVKSIYERNGRKKGQKVASPLERAQILQGGPSSSMSDKIPRKVRYREKEPPSNPSLGQTLIQGFKTIFTGRKRSSDDSSTSNTSNNSKRHRRNVKTDSLANVPQTRNKLKQQNGAHKKATEVIDLADSDSNTEDESTAQNQLKRNRSKRKSDLFAEVGSKKQAAKPVTEKPTTGIYGLLGHVTQEVKEAVPDTPSDDDGVKAQSPTKHALHSDVDSSSSSDDDKTKSPDEPDTVRRKSLQEQQLERERQGLKDVIRNNLYQTSDVDEAGGNQTEGDSDSEENFSFLPKGSVRKSKPAARLQVAQHAAKTRKNTDMEDINNFHQKKKKASRKDAAGTQPIVLDVDDDENDGTNANTKSKYFENNEPSGHPKVLPHPGMNYPDIQHPDMQYHDMQLYNANEPGPKTPSDTALPADLAVGKDTSTDAIMADFDQKVGQWKNGATPKSSSSQADGEDEDKFWGDIAAKRQSKSTNEESYSPEDAKASRRARKIAQVDDVAIDTDFEITPTRKMSKDRILQNALRKVGMDPSSLTLQITKVNGAKPNARKGKRVIPGASTATEARSQETTSSQESREFCARTSGRNSGRISTRYGTRSHSSQEREDYILAQQMQQQDDMLEASRRRNQGRTLKKKKKPATNEDEPIVLSSDSEEEDHEELHDMEYDLCRIALGKKVSGNGCRLTFSRRNNQLILFFKRPGRRGRNSNYGVEEISFQLNRETVKEFKCYEKKERDDDEPSAHSVDFNFVAIRAIPCEGSKNLDKHLNKYKPESEDAPKKERFIILEFPVDADFDHFRTKMEDHLAEICHLDRIDKEEALSFAEALVDDSQRMATSRIAIETQSSFLQGRGPENVLLVYPFTGDPTEIEAAADGLHEPSGKLKINRGYSSDESDNESDQEEASKMHISNTPSGDLVDMKEDTVSKVKVRQHYVTLRVKDYERLQPEEWLNDSLVDFWMQWIARSEDKSNTNLHFFTSHFYSSLAGGGPEAVTSWTAKKNINIFEKKFIFIPINKDLHWSLCAVVNPGCISNSYEADLDKKAKLDVPCLIFMDSLRMHRKVAIRKKIENWLNSEWERINPDADNTKPFTKDKFQLFTPAVPMQNNTWDCGVFVCRYALAIFKLRNRSFTFRDVHGDSPFSRLVAGGAEFDFNMKDIVRFRGEFQTLIENLSGVYSRWKREGEKPNPKSDDAEKSGGQEVETHEDKSSDQEMTDATKNADQVTDLVPSEQKATSSPPSGSPEDESMDLVNENESTSVAIEANSPPDSEDVVIENESGSVIIEATLPHDSEGLVNENESDFIATEHYAPPDSHNEVFADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLK9</accession>
    <name>A0AAD2FLK9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001035">
        <property type="protein sequence ID" value="CAJ1941569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLK9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1941569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="369" mass="40710" checksum="94D3F263A1FFB13D" modified="2024-05-29" version="1">MSKSPSLRRIQADIRELALDPSDRYYAHPLEHDMFEWHFTIRGADDTDFEGGIYHGRILLPPEYPFKPPHILFMTPSGRFETHKKICLSFSAYHPELWQPAWGVRLILEALISFMPTPADGAVGALDWSSEERKRLAKKSREFCCPGCGKIEALLPKLDPHKKQKANRFSKEIEKLQQLQQLSDKKKEDEEGEDKKDAKESSGDSKASDNPKASLLTTATSTSASDDQKPAAAPSPKSSAAAVPSLEQSNVTASNATATSVHVETATGDENTTETIGLLDGDDGSRDPGARVTTAGIAQENVPDVTGRVNEEAAAGAAVVEESNLSWVYDPILNLMIVLLAAVCWLLWQKFVDLRQELATLREQNLLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FME1</accession>
    <name>A0AAD2FME1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FME1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="516" mass="59567" checksum="0594DBF640C76EE5" modified="2024-05-29" version="1">MMSFQTRYIQDHTEGKHWEVVPRGSMPEGHRAMRGVWSMKRKRRVGTGEVYKWKARICIDGSSQEKGVNYWETYSPVVGWETIRSLLTLAILNGWTTRQINFVLAFLQAEVECPMYMEIPKECYVDGSELNENNVLLLKKNLYGTKQASCVWFEFLKEGLEEIGFVQSSEDKAVFYKGETIFVVYVDDGILMGPNGHEIDDVIGQLGHKYKLTDKGDLNEYLGIKMKRTKDGRELTQPALIQRILQTVGVSLNRGDRQEVKTPATKTLHKDEGGEKRRMNWDYRSVVGMLNWLARSTRPELIFAVSQVGRFMAFPKKSHEDAIMRICTYLRDTRDKGMIMKPDKNKGFEVYADADFAGGYNKHNAEDPAAAKSRTCYHIMFNNCLVYSHSKLQAEIALSTTEAEYICLSQALRTVVSLMRFFKELARKIKSFKYKRPRFKCKAFEDNNGAIAIATTENLRPRTKHINIKYHHFKRYVRKGYVTIERIDTIDQLADIGTKPLLPHMFIPLRKALIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN70</accession>
    <name>A0AAD2FN70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN70"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042205418" description="Calmodulin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19966" checksum="0ED38F0165F0DC1F" modified="2024-05-29" version="1">MFRSWLLSLFSIGIILATICSSSTVVASGDMEEPERITQDEALKQALEIFEGMSPEEMEETILEMMQLVGNDDPETKAELELLLNELIPQIKSQSNLDQMVQDDELAVATQDALRMLKGSNWDEIWAKQDIILEGVLASGQLTPESAALYRSDEEAWKEELKFIWDQLQKQAAEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNF0</accession>
    <name>A0AAD2FNF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNF0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="384" mass="42806" checksum="9F20E6C046864057" modified="2024-05-29" version="1">MILQDPISPESPFRQQKLVNGKSLRDLSAYDGYSCSLRETPEYRFSDLHKVSHLGGGSYSKVSLVITASKDQLAMKSLDPAKLGTQNAFVDAAVDLAREANILSKLDHQNIIRLRGVPCTSLSESFSDAEVSSQSDDGYFILLDTIDETLKSRLSRWRRDLRTSAKGRKKGTISRALSFDAWKKKVSKQASKVDDAKMKDRMRIAAVGVACGMQYLHEEGVIMQDLSVSNVGFDQRTGEVRIFDFGMAHKVNELSNPLQDKREEGLVCGTPRYMAPEVMQGAGGSKESDVFSFGVMLYEICTLQSFFSLDTDLQCFEKHVLSGERPSLDRTVPCMQTRNLISSCWATDPKDRPTFDEIVDVLVTILTADDNDSTLVDENPRALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPB3</accession>
    <name>A0AAD2FPB3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NnrU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS11546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPB3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009915">
        <property type="entry name" value="NnrU_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07298">
        <property type="entry name" value="NnrU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NnrU" evidence="5">
        <location>
            <begin position="19"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1948297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="249" mass="27077" checksum="857395B3F1859599" modified="2024-05-29" version="1">MKPSIRWATLGWTFFIAENAILSENRSMIIEQLGDENYHLVYGTLSTAATASIGYGYYQLRKAAQSSNVTNLLKSKPPVGNMAGAWIFMSVGIFLASQGLPRMQIPVSSSGGSSLQVRCPFDFTGKKDNDSSPVSGIDRITRHPGLWSMGLVGIGNSLLATSVPMRLWWSGPAFVAWLGGAHTDSRFRRGLGGQMDPMYDSLTSNVPFFALVSGKQGSGSWKALQHETKELNALASVAASTIWILRRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPD7</accession>
    <name>A0AAD2FPD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS11649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="263"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1948503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="428" mass="47283" checksum="9DA2E6032A3BB4B8" modified="2024-05-29" version="1">MSSPQPYHTMLTSAVTHKHMEDLIQKVNPQLSSETGWSLRRVVLSKDAISSTSQDVVLWTQYSEESSSPGNPAHYYGMVLSKTNTEGISNTGEQDDETESSSTNQLLISFYLAYSTWDGRCLHVDQFPSREECPATVKPVFLLQSLAQLAIQLGCRRVLWMQKGDPNWSFVVNDGLTPTDGSSSKTSNVIKPETLDEWLILKLDRKAMESYAGGSSSDNGSQASEPAAEATGEALDRPTIETKIQQVCADLQSTSSSSLKWRLVLEQSAMGKDTNSIFKLVQGLAEYENEPDAVQCRARDYQLDGSGSHPLFYCLLLEDTTTTTNTTCGMAFFYFGYTSNDGRFLCLEDLYLEPAFRQKGGGTLALKALAKIGMALECSYLLWTALDWNQPALNLYAKMGAVVQDGLKISRYKDEELLRFANAGISKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSV0</accession>
    <name>A0AAD2FSV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS13558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="641"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1952448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1071" mass="116127" checksum="0811A486F90DDA2E" modified="2024-05-29" version="1">MSSLPRPPGAPTRRSSSNSTSYGKTTTPRTPSPQVIKGTTRHISSGSLPPPPTMVSPNPKKGQSSNYAQNLSRSMTIEEMRELHRRAQRDAEAKQTELRLVLASRYRELVGSSDEVTKMGERAQELHELVHALPELMGKLIQCAEEDAYEEAKDAGEEAKEIDKVTILRQDLAALPRRVHRALDTNNVHEATVSLLLLFRLIAEQTQDFPLASALATDISFSPVPNSNSMLQAQIKMTFLHVQTLPAKITRQSTTILDSAASFGSTPEFGAETSAAALSTLDLLDIAEKKERTTKLLDMYFDSKAALLQGFLTELNPSNSDDGGTDNTEEILSKIVLILQYDIILHPYQMFILRNFPCAPQSGSTVEGIMKSLPMFPASIVQSKVSNFLSAHLPLIRTKVKSVLVNIAGTTASALGKIRQSLYDKTDGLECMERLDNNGICSWEEAVSGVVDVQVVLSSSHGGGGPIAHGETTAIPSKFSLWGVLFSNTFSSLVHSLLTTSFQSVHTKVVSTLRESLANAPALSSILPHEAYRNTLHIATELDSSLLKVSADAHELLVHAEERDESERRLKQSLYVQTCEIVGRLLSELRRMLLLPDKSQAVMNLIVGRLCHLLKYRLTALPTLLDPNSSPAVLAGSSGMISLLELSSAFELADDNDDGLITFQEAMEAVDSAFSGTQHHGAEMVRETLLLPAVGEKDVAPASMGANAKAYTPQDVTLNELTLLLARGLRHEQSGKHSALGTVQESLDAIITESFNKWSKEVLDPSSSSLSTSLESSIGIFSSYSEEEYKRIYAHAESPIANQVGPVVGGVSPHVTAFVLELSSILDRSVCPSDSLLPVPSVEYATAMGISGDDIPRMVDTIRWALLHNGLETVTSLLDTQIGSDSTERKTKLSEACPSGLIQLCNDISFIRTCFFVRNTYSFDKNGADHPSKTKLDGLYRDVTSLSPDGRSSSVVSRIEESHRHVFEVSDLFLSSLFGEDKSSSVPLGDISDIGSSIGQGQASGASSMFHTPVPSSCRFQLLPIQADRTLSGVQARTKLKEKEAENRADSVGTGAMRAGLGFFSSMLTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT97</accession>
    <name>A0AAD2FT97_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS13550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT97"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF33">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF3638" evidence="7">
        <location>
            <begin position="307"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="8">
        <location>
            <begin position="645"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1952432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="744" mass="86594" checksum="1CB638A8EDE3E358" modified="2024-05-29" version="1">MTIAVQLLRQCFQNFRFSKVEISKPQNLSQHSKHSCALRLLIWCIYRWSRSLQVPEELKLKQEASFELDKFPSVEYRQSSAGPYLTSIEEQSVFCFTSVFEDSNEGVFETTASSDESEISQYIRKIERYDFQSLLRSEGRHCAPEFPLTNAKENLRVAEGTNTNIRERVLVDLQKSYELYTKLSKRSVDGPNFNVFAVQTEVCHKRQLVEERLLCTLNEALISREHYDFFSGSMQKLVAGDLLHMLDSTVFIHPRKRGYRDVILEMQPKLNDWALLCVLEDKIRRLQCFWQQKKEEELVRELECTRIWNPRRFPRWVAFEVEQQLQIRPEQFKTVSQLLQKPKGSLIQLNMGSGRTRVMVPMLVLEICRQKRKLVRINVLPSILQEALLFFQQSLVASVQHTKLFTLPFNRDNVLDEFTVKLMDEELRCCHKHGGCLVVTPHDRNSLLLKQHEVHIQLKGLPEVDIIDLFDESDAILEPKFQLVYAMGKKQNLPSCANRCTVFQSLLIMLTRGECATSSDLLEDPAAFYKSKNGAGLFNHFRLLKLSGEDKERLGRNLAEHFVRNPPSGFEWLEMVNREPDIQILVKMISDPTLNTSFYIMFYPLFRRFKDDILAARGFVAFGILLRTLESRWGVSYGLRHQKDSDTQMAVPYSASDTPKQRAEFSHPDVAIAYTNLSHLYEGLTVEQFRRAIDLLEAKGMSVKISTYAMWIEKVRPDVPIEEFNRFDMYEKVDPSNVPQFELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTP5</accession>
    <name>A0AAD2FTP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartyl/asparaginy/proline hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS13758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051821">
        <property type="entry name" value="Asp/Asn_beta-hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332:SF5">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="5">
        <location>
            <begin position="372"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1952871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="568" mass="64995" checksum="8459707432281F1C" modified="2024-05-29" version="1">MLRFSHQNDESSQAEQQSQHESSSNVWLQPQREATTTTSGRIITADLLEASFTCRLYPKGDDQERVLLPLRWDSHFLNCRTRSFGSIFGIAEELRHPDDLRHAIVTITEYQRDAKTKVDTSSALHFGNPRNGEAHSEWRRCPLSHHPVASDDTIENKQSEVRSIAWIDLRNDAAALEVLFRSKASFFRSLRSLLTCTHDVSPWQNSNDSDDNSIDEIPLHHDHVVFVLPEPSGLARNFRVGDAAPSWQLQSYVVCKHLEDWDFWKLHPSLDAPSGHVYIYKRLPKRLKMSNQHPETSVPAPDGCLWETVDIKEEERVDDEDEEKEEYEDDDQNEKQICVKEHRLVCPPYVNLEELYSSEVLKALFDPEHVEIFRQEALRIPFWVPWPETQHYSVSSSAHASNPGKPWTVFPLCYCFPANQPENITWVENTNALCPRTCQILKSIQTEELGLVVRTALFSQLAPETTLEPHTGWADLANHVLRLHVPLTVPKGDLCGTWVDGCVETHQEGRPLLFDDSKIHRAFNYHPSESRVVLIVDLARPKDLPLGYATGGHSEELDSFIQQMSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUK6</accession>
    <name>A0AAD2FUK6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001810">
        <property type="protein sequence ID" value="CAJ1952637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="656" mass="73567" checksum="378B9928E4D23D04" modified="2024-05-29" version="1">MLSSATHRVRTGFGDSKRSFRPPSGVPFQGCGQGNGAGPPIWISVSSVLITMMEAMGYGFECLSALESQLVTAQCFCFVDDTDVIEAGDTVHHSGEDICASVQAAATLWSGGIRATGGAINPEKSFWWLIDFEWDACNGQWRFRRKCSAASEFDLKIPGLYGDIEPLRRLEPDDSERTLGVMLSPLENHKAQEAQLVSKAKEWAKQLRPHLLHKYDVLPLIRTTIMKKLEYPMALTTLNAQQWQDIMSPVLQVCLPKSGVCRNFPRLVVFAPVDYQGLGVPHPFGKQVYKHLEMILRHKSGGTKTGAYMDANLQAHQLETGTSFGLLQQDYQNTSILASDTWLKRVWKELESLDMYVAFDSPALSLRCHHDALLIDLFMDLKVDQDDLLWLNWCRMFPQVATVSAITTADGRYIRQFIWNGFRDDTYRTPYNWPQTVRPGRPYWELWQRTLSRALLPSHGQHHPLLQPLGHWHDHFKSWNWLWSPTVGLFHREGAAWTHLALVGSSTTSRRYAPSGSHSGTDSLQRPSSWWTCPLPSDVLHATVRPLSGSDWVLLTGTGLPTLSPSDPALSILNAWQTSVDLCTDYYGWVPDEIEVHGDEAALADALIQGRLRIISDGSYKKIWELLLFSSFPKGELLALSSVVKLQATSGSECLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV69</accession>
    <name>A0AAD2FV69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV69"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="159"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="793" mass="92136" checksum="4CC881DAC94E1129" modified="2024-05-29" version="1">MPKNIDYFLDPVKLIKHYKSCRLNQSKSKVNGYGLAEVWCFVTEKTKLEGAHNSLVDTFAQCEILHDDRLLPFLDKPAGIELMEDILEPKRKARQLLMDETKRDLPIGWVDRCDEYFTVNGQKRTSSEVQQIALNSSAGGGRRGPNMGMWNLLRQESLVDLFLNFFKKTFLQIIARETNRYGNEDWVKLTSTGGYFNFAQEGVVEDLGDEEEDTEPRSKPKRAFVPCNKDDPDRRKRHSGSKWKDVTPGLLLICFGSTPVKGATKIRKINLLWGEKWQTGIPYVQNSCTMAAFNQVRRNLHFVETSKLPKKGDRKWSPLQKIQPVLDYLQKQLSSCYNLGDRISIDESMIKYCGKYISWIQYMPKKPIKHGIKVYALCCAYTGYLYSFEIYTGKEGTESGTPREVIGRLLRMAGILPSPAGAAKMTGTVLYTDNWYTSLDVMQFVYEQFGMLLVGTISLTAKKSRTADDYPFHKYKNTLLRRIPRGWTRLAYQTVRKTAKTAATTAKAAAGKVLYLVQATLWKDKKMVGFLHNHLVQSEQDHQVKRWDKESRTKKEIPAHPIVTDYNKYMGGVDAKDRDTADWSVSLKSNHWYYRIFYWIFDSVIHAMWVLVKTRLERMTKEDLNRSKWKSFANKDTGRFEFQMTLGILLMKRGLEWDWKGDFKDPKGRPEYCRKTQWIPCECPENGVQCFFCYYGHTNGIEHQKAGVRKREYKRNFEVRTHVCDRVDLGRNPQYCNPCYHSLKKKYLGMTSRKRYLHPECKKTRLGCPGCNRGNGQHVCKSCWKTYKHDDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVH8</accession>
    <name>A0AAD2FVH8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="7">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenylate kinase 3</fullName>
            <shortName evidence="7">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS14924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVH8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
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    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="10">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="176"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="197"/>
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        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
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        <location>
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        <ligand>
            <name>AMP</name>
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        <ligand>
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            <begin position="96"/>
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        <ligand>
            <name>AMP</name>
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        <location>
            <begin position="125"/>
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        <ligand>
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            <position position="132"/>
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        <ligand>
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            <begin position="171"/>
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        <ligand>
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        <location>
            <position position="195"/>
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        <ligand>
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        <ligand>
            <name>AMP</name>
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        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
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            <dbReference type="ARBA" id="ARBA00004305"/>
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        </source>
    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CAJ1954332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="252" mass="28279" checksum="0B14130E441F967D" modified="2024-05-29" version="1">MLLHPTIVTRATSRRIWAQCMRNRGFSTSLEAPAEEGQHFAVILGKPGGGKGTISKKILDDFPQFHHISTGDLLRQHVRDGTALGNDAKKYMNAGELVPDELMIGLVMEETTPNLEDGKSLLLDGFPRTVVQARELEKSVHVDLVINLDVPTDTIVERIADRWIHPASGRIYSYSYKPPKVHGKDDETGEDLVQRPDDQPDKVRARLSLYDEATLPLVEYYEGNGVLRSFQGTKSDVIYPEVQKWLDGQFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW18</accession>
    <name>A0AAD2FW18_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
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            <taxon>Bacillariophycidae</taxon>
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            <taxon>Cylindrotheca</taxon>
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    <reference evidence="3" key="1">
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            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="288" mass="32343" checksum="6C21F033B56607A3" modified="2024-05-29" version="1">MKTTILLTQLLLNIETLQAFSPSLQRSTLTRQSQPSSTRVFSQWDDEEEEILQKSTFDEAGVALTDEEEQKRIAEMGDDTNEDYSTDDISRVREAIRQRTEALGMERSKVSVEAIQAAQERAKSAVENNLSGASQLDLSQITENAPRGEDADNIPAMFYDPETEMTKEEMIEADPDSQLNFYDQVMKEITSSTWPSPGAALKEVFVLIFVGAASTALIINWDNFLRETYTNFGMIPTEEQIMQGSENMVLPDGWTNGMSEDDFMNFREEQGKSSSPSVEAIKQGFPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWT5</accession>
    <name>A0AAD2FWT5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
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            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
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        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RCC1/BLIP-II"/>
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        <property type="entry name" value="Reg_chr_condens"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="183" mass="19838" checksum="E10CECF67B99A771" modified="2024-05-29" version="1">MKWESICAGENCVVAIDSDGVPHSSGLEHPRKLARTIANGVPNHDTRPLEQITLALSNKSLATQLNLESLKWTVLINHYLTTAENRSCFRNTASRKEVVSQFVKPCPMVFAEQFSGRATNVAAGAVHSLVVKLENGSTSVHSTGHNGSEQLGLGDNAERQVLIKIQDLDGKDIQKVAAGRFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWX6</accession>
    <name>A0AAD2FWX6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
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                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001891">
        <property type="protein sequence ID" value="CAJ1955492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="92" mass="10443" checksum="766A689F5B7D569B" modified="2024-05-29" version="1">MAAVPPFFTVHDNMVICGIDNVTLFQGRTQAERIAYKIFSDDFTTTMDSTIDELNKEFKTLAGLTIAQGQIRLMPAIKKNILAFIQWCRDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXC0</accession>
    <name>A0AAD2FXC0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="25338" checksum="F14F039BFA713CC3" modified="2024-05-29" version="1">MAMTMQHQVIQDNNFAVAMIEEGAYDEASATLRAAFQAYQNCGDMESTACNDGVSYKSSISLDECMTKGHPMSSSIDPDFPFMYSDAIRISAAAGISKHDVTSIILFNLALTYHLSALDSNDPDSDLQKALHVYEHLYTMQQQENTGESFPSNLMFVLSILNNCGIIHQWRSEAGTSINGEVIAAQCFDKLLSVLTLISSKTQITNKNEEVVVRGFYRNVVLNRSPAASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXD8</accession>
    <name>A0AAD2FXD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="65153" checksum="02C1350F79686E21" modified="2024-05-29" version="1">MTSYYNTYFGNDGETIPEATSDLVIHPHVREVPDQACYRFERLTRVDFGGSTLRTIGKDAFYRCTSLLEIKIPPSVTSIGDQAFQRCQSLTQIRFHEDGHLAFIGDSAFAFCVSLVEVSIPSSVDVIQSSAFHACNRLSRVSFQEGLKVIQSDAFAECVKLENVDIPRTLEELGSRAFCDCTSLQELNIEEGNLRDIGHRAFGNCDKLQTISIPSTVERLEPMAFRGCTSLGVLKFQNGLKYLADGSFYSCKNLQSVALPESIQVICRMAFGRCPKLLSVELGDGPRDLRIYDEAFTGCKSLISICIPPESRTTLSSSDDIHFGGVDINSFEGCTELQNQYGDTNVPIALMHRFDSFPIHKKCYHVSATTTIELAREIESSMHSSQDNTTHDHLADPFRMTPFHILLSAAVCRLDLLQIMLDAYPPYVLGWKDVNGKTAVEYLTQQSFHLDEDSRKMLRMTLQGWMVGCISSWNGLEAWKSDMSDKVNAIVAEDDVEHRQFLLREATVALSRYEQVESTTLLELSLWKIQLNSVNGVLEDGTTRTTVSKDDKEAYRIRNGASVIIPNAIAFLYESNLSYAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXK7</accession>
    <name>A0AAD2FXK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001913">
        <property type="protein sequence ID" value="CAJ1956303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="57"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="251" mass="28069" checksum="E60AE40EF0BBDC78" modified="2024-05-29" version="1">MGTYAQVRNTYPKSTKEAIKIDKANGDTLWQDSIQMEMKNNRVAFEEFDGDVEKLMGYKKITGHLVFDVKLGENFQRKARYCADGHKTEAPAALTYSTVVSRDSVWILLMIAALNGLDLQCADIQNGFLTAPAIEKCYLVAGPKFGEEESKVFIVRRALYGLKSSSAAFRSHLAETLEDLGFSSSTADPDVCMRAAVKPDGEEYYEYILCYVDDILCMSMKAKEVMEGIGRVFKFKKGKIEPPESYLGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZP2</accession>
    <name>A0AAD2FZP2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042249045" evidence="1">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="194" mass="21562" checksum="8B10421773689449" modified="2024-05-29" version="1">MRSILSLLLLIAHVTSNDLNQMLSPQCFNETKTINDDSSFEMANRNMATTISTLDQTSFCKVDTNTNPDVTTIFCNIYYNSDIPNTIEEECGKLGGHYEEVGIFFDCNLAANSQTGANAARLFSTHHEVPTCTGASCTATELAKYSEQYFEDLETLYQSYNCDISYSDPLDSSASCRDILKALLILLFCFVTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0C6</accession>
    <name>A0AAD2G0C6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS16863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001954">
        <property type="protein sequence ID" value="CAJ1957753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0C6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1957753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22729" checksum="946E69225B9AF78E" modified="2024-05-29" version="1">MILFLLGVANEHIVPRRKKMDEIDHILLWTIKVCLVVLFVTLPLALAEELPGDNYWLACSGGDVNVIERSLEQNPAWIHATTANGEACLHLAGIYGHGEVTTLLLSKGADPNIRSTWEDGLRMHPLSWNVFGGHVENARLLLENGADVNADFDSMVDKVHSVTVTDVALQLQGLEDGDVRFEMMLSLLRKHGGKTMEEIRNANEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0M8</accession>
    <name>A0AAD2G0M8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS17671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0M8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1959250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="127" mass="14467" checksum="1C23E8F2A9488643" modified="2024-05-29" version="1">MNAPERSSAFLLDEDSGEQKCVYTADTKVTNAGTFRLNKEDHTVGNLFRMQLLRDPNVRFAGYYCPHPLVHFINLKIQTNNSTVAPVEVLGSAIEDLANETDHLITQFQESIETWKRENDTEMTSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G133</accession>
    <name>A0AAD2G133_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G133"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02246">
        <property type="entry name" value="SgcJ/EcaC family oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcium/calmodulin-dependent protein kinase II association-domain" evidence="1">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium/calmodulin-dependent protein kinase II association-domain" evidence="1">
        <location>
            <begin position="219"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium/calmodulin-dependent protein kinase II association-domain" evidence="1">
        <location>
            <begin position="350"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="500" mass="56872" checksum="BDF3294091B64DD0" modified="2024-05-29" version="1">MKLETYRYLAYFLTVLGLHNADGFTNPAVNSFSRIQQRTLISSPSSFSTCSSSSSLNAFGIQTLKRILREDPPPRRDLLQESITKEQVRNLFTTWNEALLTGDSEIVAKCYCADPILLPTVSDTPRTDFDGIKNYFDKFLTLKPCGKILDGKIKCGPGWAQDAGIYEFTLGANGSKTLQARYSFVYVFEDGQWKISHHHSSVMPESTQKKTQAKILSQEEVKGLFYLWNEALETRDPHTVAKRYTQNAVLLPTVSDIPRSDYEGIKDYFAYFLKLEPKGEILESHVTCGENWCEDVGIYEFTLGATGDKVRARYSFVYVLDNDGEWKISHHHSSKMPEAPGPVVHRPSEDQVRSLFDTWNEALISLDPDQVAKLYSKNAVLLPTVSDRPRYTYDAIRDYFVQFLFKYPEGEILESHVTTGDNWCKNVGIYQFRMALTGEVVMARYSFVYVWEDGEWKISHHHSSFMPEPMLAATAAAAAIRLEEIKMEPLSVTNHTQMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1A2</accession>
    <name>A0AAD2G1A2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002008">
        <property type="protein sequence ID" value="CAJ1959603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1A2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="585" mass="66153" checksum="427D0C9E301F90CA" modified="2024-05-29" version="1">MAPDRNHWRLWQDTLTRALLQSDDPSHHLRQPLGPWFDSIDDWNWLLSPTHGVFHRHGHVWRHYGHQLGSYSSSRRFHMKPASHRTSGIKRPMAALEVAEALSPSVPFWTKPLPDDVCRVTTQPLHGLEEIVISGVGLEHQPPRPVPQPSLFAAWEAASAEVDEYFGWTPEELEIVGDEGRLVEALLSGHLCVISDGSYKRDLGTVAVQLLPRKGETDRIIVRCQTPGLPQDQSAYRSELIGLLAGIMVVDWLLHQWAPTLQSKPRVRIACDGFSALLNTFSNNRVTPQQAQFDLVSSLREALARSKASWEPSHVYGHLDHATSFSSLSWWSKRNVEVDNWAVAYRHQLEASDQLIAPNARFFTELAALYIGDVKQSRLDPDYIQELVALPALRKRWREKLTVTPEAESETDWTSLARAMRSLPVGVQRWTTKHVVGMCGVGKFKVRWGYDTSAACPCCGEFEDHLHVPRCMAPSTSAEWDRRTVALDLWLDTQVTDPAIKHALLSLLKGVRDPSLPSIRVVPGRLRSAFRSQQCIGYQGLLEGRLSRQWAPLQEEYLQSRGSQRSPTLWASRLSHQLILLGFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1S5</accession>
    <name>A0AAD2G1S5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1S5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="397" mass="45531" checksum="8BDECA1C1870B095" modified="2024-05-29" version="1">MIPHMHWRNEKPQYAEIGDSDDRQDTEVRKYPYFPVQRVPDGDQMNNTSSSTLNFHSSNSSSSTLNFEMSISDLPSSLPNGEQGSSSSFSADFADFPLIPTVQDKPRARPTLRRTGSINRRRPKSSDATVRRRLSKDSMLQKTAILQSIKRKDSGSDDKRSLDSSKVHHRSVHRGRGDSIGGDKDSKSIDSSLHKTKLHHGNHWHHRSMTRLSPPRSFERQSRSQRSLQVSSSRSPSAEKRELDRTIRSHRRKERRSDSDLHSLKSTSTEVEGVDGCSIIRPNYRFRRQKSFEHKPPAPSSEAKVLRSQSHERLQAKLAKHELAKHEHEKLKKRIDEQDCKNSMFKIRPPPRMSISSSHHTKREISDICHKTSQHYSQRYAPKRSDSSESFADDIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2A8</accession>
    <name>A0AAD2G2A8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002043">
        <property type="protein sequence ID" value="CAJ1960055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2A8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="207" mass="23836" checksum="6022A56EB7C8553D" modified="2024-05-29" version="1">MQELCSKVKTQGVSFIQQYYLNKGLKLFKDCGKKAAIKELDQLVKQQCWDPVHVEELTKKEKEKAVGAMILLAKKHTGEVKGRCVYKDRPRILQLCYVQERQEGTLCCNLQGCLWYAGRISTLLQEIRADLEGVGFNFNPYDPFFPCGRFVVKPHNAKSQWLNETYGSYKECTSTRGKVHVYLGMTLDFSKEGKLKICMDDYRKQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2U8</accession>
    <name>A0AAD2G2U8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2U8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1960428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="166" mass="19084" checksum="7BE1BDDFA0ECBB68" modified="2024-05-29" version="1">MCKRIDMHQSHVAVSPKDDLIEEIGGKEQYDFLILSFCEKIQEESELEEIFCHLDTEVLASRMNSLVDVAFALTESRCQDEKLRNDVLLKNYSLLELGLYASHFEILQQMFEAALHESWIEAEAFDRCKTRFEMLRNIIAEDGVGMEEIALSHRVAEVRILAAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G434</accession>
    <name>A0AAD2G434_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G434"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041113">
        <property type="entry name" value="Heliorhodopsin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038020">
        <property type="entry name" value="HeR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18761">
        <property type="entry name" value="Heliorhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="364" mass="40835" checksum="9CA5CCE8633283AE" modified="2024-05-29" version="1">MSSNEEPQEQHPDDDRTLGTTNTRELTNKQAMNSRPKETAPNEQDAVLGGSNNNNNTVTNYDDDAHYLEPRGLNEIPKVLNVLHIVGALVQTAEAIFLFAFASNINLKWLLYTNYPVAVDNALASQIGGEGTDNVYFARPESKYLTSFSVPWVTGAIVLLSAIDHIFAIMPGGRQLYEHHLARNKASFRWLEYAVSCSLMNMHISQLVGVTDVHIIILVFVLSISIQYPAYIHEVVNARAREEGFAQYWSPFIFGCIPWVAVWGVIFSYYHQSIATVGEDPPSFVLPTIVAVFVLEGLFPILFVLQWLKVGIFKNYVVGEYGYMILGLIAKSSLAWITLIGAEKYAESFQYEDEDMTDVFFSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4F3</accession>
    <name>A0AAD2G4F3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS18977</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4F3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1960975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="15691" checksum="9C4C176D542CA131" modified="2024-05-29" version="1">MIRSKLSTRAPLLARRLAAPSKKQMSSGNPLAADSGPLSTHKFHTITMSLAIVAPTYFLIPSSMTDGFVDKAMGVILAGHITAHQWIGMNYVATDYVPKISKSLMGPARIVNAGIAGAILLGLSKIALTSPGGIKGVLKGLWSPPEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G555</accession>
    <name>A0AAD2G555_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002140">
        <property type="protein sequence ID" value="CAJ1963354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G555"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="142" mass="15576" checksum="F786BE8ED9EEE364" modified="2024-05-29" version="1">MIRKSSQRGAFEELTMQVDQKACKRAVCAGVIHPFLSGCVVSAVEQNWKLGKSVGEFVGQAWMGMGSSFKADNCGNFLEKGYQELKAVDVDVVGVAGFQFCTSNNIWAPNDAEPKEKFVRIGASSKEASVRTKQNVLYRECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G982</accession>
    <name>A0AAD2G982_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS20717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G982"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="539"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1173"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1964614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1203" mass="137450" checksum="62288068A90FC71F" modified="2024-05-29" version="1">MMKRLQSSPRHKVTRKHHSGSTDSTADHHAKDTDSLHSDSDRSTSESFEKRTESEFERNSIRCIRYFIGFLMIGVTASGVFLSYKYLKDQQDTNFTMEFNVIANDIQHLSSDRVTELLGDTQSLAHSITTMAINSGVDWPYFTDPNFGFVVSSFMTLTDTHVLSLAPIIHDAVENANWTKYAQANKDWIQRGLEFEKREPVENATFFPSTYRMSAGVKIPERGQGPFLPVWQTAYTPDDGGVVNFNLLSDEHYSTVFDSVLEGKKAAMTDTSHHIIPIYSSNVDFDELHDFRHDMHHEETPNSLLLYPVFKDSTEDEIVAILNADFDWVTAFALSTDEEMPAVDVVVDDMCGQTFTIQVKGNDAHFVGFGDHRDPNYGHFCHKFEFAPSLDMHHTGGDECSYMIHIHATKEFSEKYHTSLPKMAAILIAAIFLFMILILYLYDAAVNARQKRILKVASKSEKLLSVLYPKTIRDRLFHVNYNSDDDSTAGEGGKQSDLLKKATKYQLKTFMATALPTGKANSLEFFDSKPIADLFLHATVLFADISGFTAWSSVREPSQVFTLLETVYRAFDVIAKRRKVFKVETVGDCYVAVTGLPEPRKDHACIMAGFARECVDRFGELVGVLETTLGPDTGDLGIRVGIHSGPVTAGVLRGDKSRFQLFGDTVNTASRIEATGRRNRIHISEETADLLALAGKADWLRRRDQLVTAKGKGNLQTFWLMTKQDCKLHELGYTTAEFQQPEQQSLEMSLPEEITQASLNLSTSSYEDIEALLSPKMKRLCQWNVDVLARLLKQIVAHRLASQSNHHKTLYDKELTMREGEIRCQFMVLDELVETIPLPGFDQKVYKRQQNPDDIVLPEAVMEQMKLYVACVAAMYRDNPFHNFEHASHVMMSVSKLLSRIIAADEILNANENAAKSHDFGWSLHDHTYGITSDPMTQFSVILAALVHDLDHLGVSNFQLIKEDHKLAHIFKNKSVAEQNSIVLAWDTLMHPRFCEFRRTIYATPFELERFRQLMANTVLATDIFDKQLQTLRRNRWEMSFSGPKPITRDETKDNVNRKATIVIEHLIQASDVAHTMQHWHIYRKWNERLFHEMTVAYKAGRMENNPAEMWYKGELGFFDNYIIPLAKKLKECGVFGVASDEYLNYAMENRREWEEKGEAFVKELVQKYHTEEREDTNKLVQSHRRNPKRMSLDFSKPQFNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9E5</accession>
    <name>A0AAD2G9E5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS22367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9E5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="239"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="559"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1966784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="109248" checksum="FF6386A7BA608134" modified="2024-05-29" version="1">MSSRSGEDVEEAMQRLVRAMKGHADVASVSLARRVVSSQIGLSQDRKATNVTNAWRRVSRKAPYQRHKAELERVYNDLNIRCARSGDEDLPPKVITVMTKLMGKHIKCATPEQLTSSSVATSPVVNSEPLSQPPQSSYQQPIQVSTPLSTVSQPRQPYQNLQYQSAARTEPLQQREQHQQQEQVYQHERRLSSTSTALSSVSFFPNTAQSQGPLVRSEAREQQIQQNRQGLEHEEAALLRECLYSLQGIDGERIKYHFNSSNVLSNCVDDYEGIRVQSPALNNPLLYTGQSLETRLGSGAADALRISGEAGWLYHRTQSYIHQVQQDDSKGILARAFAGTLSEELQEYHSFLASLEAKLNDVSLRQLMVDLRKPTHRLKILAMLTDGLGDLSGGNLLSAIYKHTLHGDTRHASLVKGILGHVSKPWFDVLFRWSTQGVLSDPHGEFFVQEIPNVKDKFLWTQRYEINRDLVPTGILDKHLVEPAFNVGKGINFIRRCLLDGTWTMKLPSMDSADLGYSCKPSSRKGNNSNAELQKTLKRAGELVHSHILLTLKKENHMMEHLLALKQFLFLGQGDFFSALIDGLFTEFHGHQGIAGIYKHSLLSIVEGALRSTNAKYQPQFCLDRLQVELLLGKDEDANFMFGPGRSPSQQGDKRTVWDIFMLDYKVPDPLIAIVDPAALKKYKKVFRFLFNLKKVEYMLNYTWRQNATLQHALQTTAQYNGIDKSADARYLQSTYLLRKISILRQSMMHLICNLKSYLMFEVLEGGWQKLVSDIDKAKTLDEVIEAHKSYLNGIVRKSLLKADSNELTSKQYLGEQVETLLSMADEFCSMQEALFRESLQLAAVATEKRLRAETRLQHGHWGFNSQQESAEDDNFFGLANTPMIKEVDRISDEYEQNAVELLKVLGEIVNGNLDDYVDENKNKSNVADITRMGASATDEFDSDLDPQRFLVAQLDHNEYYAKQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA32</accession>
    <name>A0AAD2GA32_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19047</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002081">
        <property type="protein sequence ID" value="CAJ1961115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA32"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1961115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="410" mass="47675" checksum="CB31708AB73D7C9D" modified="2024-05-29" version="1">MPKVYKPNKAFMRLRTAIIYNKRPRHVFLMMLLTILLVLLYSFKRNGSSLLSILLFQPRTPPTRAPTLSPTTAESFIEGSSPYTPGQLEEAMMKVSTTREDFRYDVQFIDECDLFLNPNRTDFYQPYHDVVESLDQYAEAVKGFHTSVHDLREVPPEEQEALCGSMNDLLWKQDGDDGGDTIFQTNALSLTRGGYVEQLLPPLRHPKFCEDPFSLDHLLEIDYLVHDFGAICRHLTKHPKARTVFFDLGASLEFHGGVDNPALTLLELYQQFGVTFDHYYAFEYTPLPPAQVFEKIPEFLLDSYHWFNIPVDAEPSKKNNPWTSLLSRFHEDDFVVIKLDIDTPQVEIPLIHQLLQEKYSTVVDQLYFEHHVRMKHLYRQWQRTAWGTLQDSLDLFTRLRKTGIAAHSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAQ8</accession>
    <name>A0AAD2GAQ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAQ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343">
        <property type="entry name" value="DETHIOBIOTIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF10">
        <property type="entry name" value="DRTGG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="500" mass="53800" checksum="CC95BB6FAE0CBF2B" modified="2024-05-29" version="1">MSMEIDNNGIANAGWSPWNPENEESLCQRLLKEAMDHRKFDINIGLYLVHGCWNQQIARQKDTTVQALLGKLASPSIPKNSEYIKGRLEIEFEAEGDIEACLDSKLPCPPQDLPAVLFYIHKTSMKAPVFQYLSSLSAKQIGSYFKGGSLDFLHAVHQELNENLQKYGVPPTIPRPLSSDNADGSGALRLFIAGDRMSVGKTSVCLGILGNLVALGYPVESLAYIKPATQNESPQLVQKYCERMGIDCVPIGPIVYYRGFTRAFLAGETESSAELLAKVEVKVDEVAKGKKIVIVDGVGFPAVGSICGTDNASVARASGPLDPLSGKRIPAPALVVGGSGVGGAVDAYNLNATYLEGAKVPVIGALFNKLNLEGFYSLENCKQQISLYFATNGHQQRHGRKAFGFVPLHDSLATSNPLEHVDEYIKVFGEHADISGIIQAAQAKVNEYFTTDASSRVASNEESNTTHASKRQKLVNGQSASRTRAEIEKAAISAGAAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB90</accession>
    <name>A0AAD2GB90_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="220" mass="24231" checksum="4FC4A106A92CADD5" modified="2024-05-29" version="1">MAQQQKQQRQQQQRQQHAPRRTSTSSDNGTNSSGSSSAFDVLQKLFLDPISACYAEDAYNMVEDSNTKEWSIESSSAGIKSPSRSLDSYYYGEEGEQEEDEDEDDLPLNGLIDESMSHTKSIKSSRTSSTKSSASSTEMAREHSSSSRHSSAYGIPILRDLPSFPTSSHSNASGFSSPARYNISTSRSMASEVSSLMSEYETKLPNINTMRKPINPAMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBB1</accession>
    <name>A0AAD2GBB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002374">
        <property type="protein sequence ID" value="CAJ1968279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17616" checksum="08FD42F3CFEEAC55" modified="2024-05-29" version="1">MKWMIGASFAVHPDLKSHTGGTLSFGGGAAQVMSKKQKLNSRSGMEAELIAVDDVVTMILWTKLFMEWQGYPIEKNILYQDNKSAILLEENGRKSAGKKSRAINICYFFITDQVEKGNVKIEYCLTDNMIADFMTKPLQGEKFRKFRDLILRPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCB0</accession>
    <name>A0AAD2GCB0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="335"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="561" mass="62645" checksum="4B83F0C9F586C4D7" modified="2024-05-29" version="1">MPNQSSGLSPHNLLTKTRWKQSQLADVQVWGCPVYVLDKHMQDGKKLSRWKPRSTRQIYVGMSKRHASSVPLCLNPDTGAITTQFHIVFDPTFLTMATNIDDLPDFGSEAWSKLFGDSVYQYVLDDPEDPLHPPDPPPPLTARVREQTEFHNLPTPLDVVPPPTKPQVDSSGATKHLIQRETVIENPPAVPPVQPSPSQRENPTASPRKPAPAPQPSATRTSRRFNKAQPPKRFGYDGHGPAGYTAPLKSQSPETNNFYTYFSAYFNSLNIELEHSHDCSFIPSSYKARATKDPDVFTYNEAVNSPNSEKWTAAAKKEIEELEGKLTWIEVPMLKAKTKIIPGTWVFRVKRNPSGEMTKFKARYGVRGDLEEMDVDKNTFAPTVAWGTVRLFLVLCLILGWASVSVDFSNAFIQSKLDKPKWVHLPQGFVSPKGKGTCLQLNKSLYGTKAAPALWNKTAMEGFTKCGFKQSDFDPCLLYKKGLMVVLYVDDAGIGAKDPADIDKLIEELRELKFELKKEGDFNEFLGIKFDKRKDGSVKLTQTGLIDKVLEAAGMTDCNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCC5</accession>
    <name>A0AAD2GCC5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCC5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042285965" evidence="2">
        <location>
            <begin position="21"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="670" mass="70908" checksum="F4151DBBF5712B6D" modified="2024-05-29" version="1">MHVPLSTLILVALVGHQADARLSGNRQLIGGLEGLNTSPPTSAYEMLNGQNNIDDPDADVLLGAGGHGEQITNPYQFDEDGKAIYEDSPPGEEAEEDNLDGIAYEQEGDGPEDDPLLGGGGHGQQITNPYQFDEDGKAIYEDSPPGEEAEEDNLDGIAYEQEGDGPEDDPLLGGGGHGQQITNPYQFDEDGKAIYEDSPPGEEAEEDNLDGIAYEQEGDGPENDPLLGGGGHGQQITDPNHFDEDGNAIYGDSGTNGTDDSPLLGGGGHGQQITDSNHFDEDGNAIYSDSGTNGTDDSPLLGGGGHGQQITDPNQFDEDGNAIYNSNPMNAGGTNGTDEFGDGKQFDGFNMTIDDEMNMDDMDMDNTGMDIDMDMMNGLNDTDSGNQNSTGLDGALNGNNDNDSPSDDTDGETDLVGADESINGDQDDDGNFPWDRDGSTAPSPAFSGGAGGGGLPSYFSPSQTPIGENNFGRPTYGQPTYDQNSYAPLPTLTPSKEFGSTTTYAPTSLQNVPTWNYPEPSSKPVAYIPPEERDDDYTDGEDDTQGEKDDMQGGSSIDGTGSIGDYIYFDHGEPIEEMEHDRNVVIALGICGGIGLCLAIITAQQMLENPHGCCAGMCRILVSATCGVTRCICWPCRKICGCTGRQERYSNELISGGGYNEEYISDLELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDZ7</accession>
    <name>A0AAD2GDZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002457">
        <property type="protein sequence ID" value="CAJ1970055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDZ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF498">
        <property type="entry name" value="DNAK FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="134"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="648" mass="73601" checksum="A190485AF7C4C43E" modified="2024-05-29" version="1">MLTINVPPTSRRNPRRKTRYSHGNRNGERTDNGPVACAIYARENNLLGLPGWKRFRSKAKKEKKLLCLINQAKLRSFRAAPRYMYGFEIPKDYKDALRLDKLHGNTKWQDATKVEMDQLAEYKVFIDLGRGTPIPKGYQKIRVHLVYACKHDGRHKARLVADGHLTDVPLDSVYSGVVSIRGLKMMIFLAELNGLELWATDIGNAYLEAYTKEKVAIIAGPEFGPLQGHTLIVSRALYGLRLSGKMWHQRFSACLEEEGFFPCKAEPDIWMRPTTDGSSYEYVGVYVDDLAMAMKDPQAFVDKLIKVYKFKLKGTGPLEFHLGCDFYRDKHGVLCMHPKKYIDRMVDSYQRMFGQRPKTNVWSPLEKGDHPECDTSELLDSEGVTQYQSLVGQFQWAVSLGRLDVTTAVMTLSSFRSAPRIGHLNRAKRVCGYLVKFKEACIRFRTGLPDYSDVPEPVFDWANSVYGCPTEEIPRDAPPPLGLAVILTHYVDANLYHCLLTGRSVTGIIHMMNGTPIDFFSKKQSTVETATYGSEFVAARTCVEQIMDLRQTLRYLGVPVKGRSYMFGDNESVVNSSSRPEAKLHKRHVALSFHRVREAVASNMLSFIHIDGVLNPADILSKHWGHQQIWPLLRTLMFWSGDTADQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGE2</accession>
    <name>A0AAD2JGE2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS11098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGE2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1947341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="52297" checksum="74B4186AC21A3801" modified="2024-05-29" version="1">MSANFDPYQPSDTIQTVLSFLMVPTGILSTWGSSCIIRSIRKERKWSPYRRLMIALSICDIFSTVAYVLQPFLGPRESPYAYAQTIGNDATCTLMGAWSQLTFMAHWYSAALSFYFVSTVRYGVSETTFARKYERWIHFIIVTFHTVTAVVGAIGDVYFQRQINPGCWVAEPPYTCSGMNCHSELIAYIFGFPTVIALFVVLINNRLLYTHVKKTIVEGHRKAIEAEKRLRMYQQRQQEQPLQSSDTTKREGTTSPDQTNTGTPTSALQSSDKQWERVRQVRIQSTLYVVAYLITFAWSAIINILNSRRFQEQYEYAGRLYLPLLVLQSIFLPSQGLFNAMVFFRPRFMATRKKHPKQTRSWCARQSIQFEHIKPSSDLGSQDIRGVVVMKEEEAGEDEVVQMSKRDPSSIIPPDIVSGEEPPSAAQESERYFSSGRPSNGKLASEKTSVLIASTDSWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGJ5</accession>
    <name>A0AAD2JGJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001731">
        <property type="protein sequence ID" value="CAJ1947556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="210" mass="23399" checksum="CCC1C6C9932D5DCA" modified="2024-05-29" version="1" fragment="single">MYGIHPIRGCYTNLAICLIGAIIIVHPSHAFFIVRQQQQQQQNRHPEDPTTVRLTSSFVGMGRTDLCLRPHLNLRNQNHRQYPSLTSLLLRASSTAISGDDDILNDDDDNVSPVDEESADDINNADKDDQETVLLVHQFVARVQESIHEQTFSSLVLRGVPKPQKAKPKTSTTTMESSSTLGSTANSLRGVIRQVQGRLIMSKQKNTDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGM6</accession>
    <name>A0AAD2JGM6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001726">
        <property type="protein sequence ID" value="CAJ1947434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="622" mass="68776" checksum="405B44083374E7AF" modified="2024-05-29" version="1">MPKVRHALVSSSSSSSSSSGALATQLDVSSSSSTGSSSTSLVSSSDSSGSESTAMTPAAGSYVPRRRSEFDSSSSSDDYSDPHSSPAQTATSPDGNDRPGNDAEGMGAINDPDLKRLREQYKEKIRMFERLDLKGYLDASEGPSKDALQYGYDADSMNLATQNLPDIGFLRQSGFHFKKASANNKPYRARGGVRKSRKSRTGGLRPSKGDVVMKGPTPLDQFPSFTIGKIYFNGISMYLSVHVLMETAVGQSCHQDIINTWNAVNRWAYGCSKRSILHLHRNEKLGLDFGDDDMNSTVNLYRLVASGSYGFGEAGEKDQGIESISASVTSLHLALVWFLLGAIADAEFELEETDEDSAHALYYCSVFLLQGAGFKHKWRERLGDKDSVQRKCDFCPIQQRVECNDWVRGKVVETHELAKRRFFRQDVSYHASTRCAIDIAVIVHCKGDWQVLPCGKLAKLTIAEAVKTRASAAQQIFDKVDDEDEYGDEEDDDYDDYGDYGDYGDYDGDGDDDDDDDDDDDDDDDDDDDDDDDDDDNLFCDLALLERVALLEGRIQFPKFGTTGEFGGCQIKRDTLAMNATSTDTYQPDEDDDHQSVDIDYAAQNPRAATIIQFYLLFEIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI80</accession>
    <name>A0AAD2JI80_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI80"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="142" mass="15976" checksum="38B2B1A85BFC4DCE" modified="2024-05-29" version="1">MAHKLKNMHPDVARELLRHVRPNPRLAKTSKNNSKSSSSTKVLLGCTAFVAFAGSLPYWATKTIGNLTEKEEALSAAQVRRGAFMNSGSRDAGKDPNWDWKNGKYVYPKGFAEHLKRQNPNETDLGPDIGPMVREEKDRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIQ0</accession>
    <name>A0AAD2JIQ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS14912</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF44">
        <property type="entry name" value="HISTONE DEACETYLASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="374"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1954320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="425" mass="48228" checksum="2FD5684D1CB59D6F" modified="2024-05-29" version="1">MTDQRRVSYFYDAEVGNYHYGQGHPMKPHRVRMTHNLVVNYGLYRKMEVFRPRLVSPTAMTRFHSDDYINFLKVITPDNMQDYIRQLQRFNVGEDCPVFDGLFEFCQLYTSGSIGGASRLNENMVDIVINWAGGLHHAKKAEASGFCYVNDCVLAILELLKKHERVLYIDIDIHHGDGVEEAFYTTNRVMTCSFHKFGEYFPGTGDVKDYGYNEGKNYAINFPLNDGMDDKAYRSIFRPVVGKIMEMFAPGAVVLQCGADSLSGDRLGCFNLSVKGHADCVEFVRSFGVPMLVLGGGGYTLRNVPRCWTYETAVLTGENVKDELPFNDYFEYFGPDYRLHLPVSNMENINSPEYLDTTKSQLLEILRDVEPVPSTQIQTGQVESQLNPRSMQMEVDTPGPDEGDPDKRITHEDTGRKEHASELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIU8</accession>
    <name>A0AAD2JIU8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIU8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041919787" evidence="1">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="139" mass="14938" checksum="8EBB68C96266DB3B" modified="2024-05-29" version="1">MKTIIRFALLAIAILSVGVTGQSNYEEGRFALSDSRPQSCELIIDTSRFYGTCCSLNTTTANGCVLNVKNGWCRITGQFWSYTWNSTDDRITCDGSEFEIEYTPDRTTATGGTNTDSPAASVPLAGLVALSAAISAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ41</accession>
    <name>A0AAD2JJ41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001874">
        <property type="protein sequence ID" value="CAJ1955016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="82" mass="8353" checksum="1D6DCA178EF4CC46" modified="2024-05-29" version="1">MLCDDQSETTNRPHALLSGAPTPAPAPAAPAPAPQRLRLLPPAPPVNQVPSGDASALTAATSATNLPQIRQQVSAIVNSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJU2</accession>
    <name>A0AAD2JJU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJU2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042162589" description="VWFD domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="2">
        <location>
            <begin position="318"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="568" mass="62633" checksum="DFDA637A32837176" modified="2024-05-29" version="1">MILALLSLLLLAVATSAQPYYDYTLQGTQKCALINVAMDESGSMFTEQVFLKDVALPGIVSTLQTPAYGFDHVFVCSNGFGNPPANPGVDPDGYRFIGCSDGLTLAILDWSRSFAGTHEDGYTALIKSIDRVPAAIDGVDLAQTCGSMAKNVILVSDEDRDHHTADAGVTQASVVNKIQDRQYVANLIVNVYIGDIDASNLGMRYNYDPAVQAALVPPTYPNEVFVAVKLANGTLDGNYDLVPYTLMDYTGYITNGQGNTVADYATLIENTPGAIWSIQTLRRGILLGQPELSQAFAKAFIDIKTCEIAMCRPPEAGGDPHITTWKNEHYEFHGQCDLVLAKDPDFGNGLGLDVHIRTKIVRYWSYIQSVAIRIGTDVLEIQGNSDSNLDPDYWINFEHLGDLDTFAGCPVTQTTSGPHKRSYQIDLRTKVPGHSLRIDLFREFVRVKLNGEKTAYHQTEGLLGDPITGKMLARDGVTEFADYVDFGIEWQVLPYEQKLFHEMAPPQFPELCLLPEDPRGERRRRLAESEISVEEARRACSALQDSLSIQDCVYDILATQDLDMVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKI7</accession>
    <name>A0AAD2JKI7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001991">
        <property type="protein sequence ID" value="CAJ1959301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKI7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="152" mass="16985" checksum="844166396CFE7390" modified="2024-05-29" version="1">MTDVEGLDSVDSFANRTTSQVCEDIKSMQRAPDPNNANATIGVTARESMTIHCISKYGKLLILVQRTHTPALGTIPNLLFIGQFYDENPDLMEGDSYPLPPHPPKFNNRDGRIMMENIESWARTAYGYRGICLDYVFRENSELPVAGDPGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLV4</accession>
    <name>A0AAD2JLV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002120">
        <property type="protein sequence ID" value="CAJ1962785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLV4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1962785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="505" mass="57197" checksum="0A7CBA0C5A2ABDFE" modified="2024-05-29" version="1" fragment="single">MIWSVRNMTHVDFEALRGTQTVYKPGKNDSEFHKSSRQTQLDRNWENLNNKIDKREVIYTTNQYTVAAIITKHFITQAMRDKLSNETDWLDLKEDHVMLLKRMKTFMTITDETEWQHFGLMESLKRFANCTQKQNESVNDYRRRFEAQADQVFEILGIDVLHVYATKTMGYLDLYDPEDDPDDTKALQETFKKEVLETFKASAFFYNCDRSRFQSMLDKANQTYAMEFKDYDQRNEYPTTIDQVAKALIKHKPDNQKKGLTTPRHTPRPNTASGSAPDGVSNAQANARTTSSQPAFSCWCCGDTGHGVTRCPKRSMRPRAEWSDPGRYSDAPTTTTSRRAGRANLQVPAAASAAQLDAASSVTGTQSTGQQHQSNMQRAVVDRSGNGTSGTTDVPGSYVVRGRSVADGRSNGRITGWNLAQVRVRLILKKKAVSTEDRGELLMKKWQAQLEAASTFKDDDSMVSDGSLNMQIYKTTSKMDSLKHCSLKHCSQWTKDNKKPFKSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMS7</accession>
    <name>A0AAD2JMS7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMS7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000001">
        <property type="entry name" value="Aldehyde-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="228"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50261" checksum="151AE3F948EC1DFB" modified="2024-05-29" version="1">MLWHKVPNSIYFRRGSMATAMEDLKKFKRVCIVTDSFSYKQTPFVHELIDLLNAKSSHQNYLDYHVFYEAEDATEGTIKKGVDVMRNFKPDLIIVMGGGRTMEAAKLMHVLYEDPTADLKDLSDDYGGMQQWLSESCENNKNNNDSTSGTSIKKKKEFPKMGIKAKLVCIPTTSGSGTEVTPFATMVVGGGALGNFQHRRCPIAHFELTPFMAIIDANLVMNMPRDITAQAGMNALAHTIEAYASVCSNEFTDGQALQALKLLKTYLPRAYLHGKEDPIAREKVHNAATIAGIAHANAGMGICHSMGHALETLLNIPRGMAKALLLTNVVRYNTTHYTTSQEEAEAEQIMECQYAEMARHLRLTKPDDDSKDASTAFVEWLNKIKEDLSIPTSIQEWGIKENQFKNQLESLVEMAWEDPCVSTNSRPPSKNDLRTILLDSYYGRPYLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNT4</accession>
    <name>A0AAD2JNT4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002335">
        <property type="protein sequence ID" value="CAJ1967525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNT4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="230" mass="25916" checksum="BF16B81CE0BA6096" modified="2024-05-29" version="1">MKDNIVNPPEKDPNLIMTVADQGQGGLEEKTRSNLTTQSSIALTKDNPAITTPKRSSKRHPSETPEDGAMKGRSLFPSEVPQGQDVTVNTRPNLTTPLSIELTKDNPPDPTTSKSQRKHPPPSKTAEDGAVQGRSLVAYITKLKVSKFHRLYKKAWRQEMFALATAQRVITTDKKSPCFWEFSLVFDPTLIVQRAEPLTWMWRTASEFFANPAIIPHIVEEFERQNESYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUF2</accession>
    <name>A0AAD2PUF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS12378</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29415"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetate(out) + H(+)(out) = acetate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71803"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>formate(in) + H(+)(in) = formate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:80887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>pyruvate(out) + H(+)(out) = pyruvate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64720"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015499">
        <property type="term" value="F:formate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="362"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1950013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="43861" checksum="1CF155F44EA3B45F" modified="2024-05-29" version="1">MTRTSEQSSTTPPTEHSSMVVGSDGTVLKRDCDDEGEVLHENVSNVQKLFRRMSSSNVSGDLERGVPRQRKLHKMLASRGHSQPQTVERQESMKKIVQQVTLNYSPTKSGKDTLEAVYKTGEYKAALPLNILVVQSFMAGIYIAMAGHLYLAVGGGALGAAMFPTGLIAVILTSAELFTGDSLVFVASVLGKRVAFSKLLRNWTVSWIMNFAGCLFWAYLLAYASDSLESLDKIDFAIAVALKKTKPSWGCILLKGIAANFMVCVGVWQAACAEEVAGKILCLWFPITAFVLMGFDHCIANQFLIPLGMMLGADISIKKLLLEALLPATLGNIVGGGLLVGGIYWYVFDSKMKNKLRLPVVRKQESSQSNGKPAASKDTNSTDTMDRNHKPSTHLEEEEQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUM7</accession>
    <name>A0AAD2PUM7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Guanylate cyclase</fullName>
            <ecNumber evidence="2 13">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS13058</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 13"/>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUM7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="553"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="942"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="593"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1139"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1178"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1221"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1140"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1200"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1222"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="580"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1951408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1250" mass="137810" checksum="DCB52FA6F0DEAB82" modified="2024-05-29" version="1">MSSSSVLTSLRELDAARLQASRTGGILREDDSNIDIVQTTNSSSVPICHLSTLLPFTFGDFVPQRFAFEFAVGIALAAHQMNVGDGSVIPILDGLSERCNIKFTVSFSDTQLNSGVALEHIVDQIGRNEGSPEPKPCAFVGAYSSSNSQPTSIVTSLFGYPQVSGSSTSQELDNVGQHSLFARTIPSDADNAVPMLKYFHDVLNVKRFAIVHVNDSFGNGFVIAFRRAARIYAPDMEILAIPLLDGDERRAAEALLQSGFTYVFCLAFTNEVHDNLMVAAHELGVAGDGTHSWFFGDSFVGTLKGRSFEPGSALHKAYNGVGMLEVAGGLPGDPAYDSFVSELEKLKNPEDLEYLGSLFPQYNAPQYGSSPPFIDDDTFLSTALQSTYTGLFYEATIALGLAACSAMSGNTLRGQTHFDHLSDGSFTGVSGKVAFNTTTGTRDPIGATYQILNYLSEEVGGSVTFGEFTTDKYQNGEWGQVREYIFNDGTNVAPPDVNTMLAPTADPIEWVIRIMVPVGLGLLAVVLVYLFFERKRKQSDTLWYIKSEELYFDDPPEIIGRGGFGLILKAEYRGTHVAVKRVLPPRFRENNKRRFRNSVRTDSTEKTTLGELKESDKEGDKDVENVTDNIGMKSVGENSMPHILTMTGSVREGSNPLKMSSNGRNSAGEGTRRQLRKTFMREMRYLSKLRHSCIATVMGAVVEHGMEPMLVLEYMELGSFYDVLHNETMFIESSVMLHILQDVSQGMRFLHASFPQVIHGDLKAANILVDSRFRAKVSDFGLSQDINSSGCTGTPYWMAPELLRGDCVNTTATDVYSFGIILYEAYSRKDPYDGEDPATVLNLVADELVHKRPPTPNNMPAQIESLMKDSVQENIDRRPTFEEIDLRLQRLDSDDLVAKGGGSSHFGQRTTSISLYDIFPKHVAQALREGRAIEAEHHDMVTIFFSDIVGFTQLSAELEPRKVADLLNRLYTKFDALSRKYDVFKVETIGDAYMAVTNLVKEQESDHAKRIAEFAIEAIKEANETIVDTDDESKGYIRIRVGFHSGSVVADVVGTRNLRFCLFGDSVNTASRMESNSKANRIHCSSAAAELLSKQAPELPLRSRGKIPIKGKGNIHTYWVNEGSKSGVVEGKDDEVWVPKAKRRSSGRQRQRPSLLGISDARKSAANFLLRPLDRLKDKDRNRDSNSKSSEFSLIRDSHNNSNHSRSISLHSVDLAKVVEQLGSSDDSSGEINFGGSSNTGRRSRSNSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUU4</accession>
    <name>A0AAD2PUU4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001809">
        <property type="protein sequence ID" value="CAJ1952622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="110" mass="12525" checksum="CCE81AABA20EE4CF" modified="2024-05-29" version="1">MRHCAFKPQNWDSFFETCLSIRIPLRVTSLLTRSKKAPSKGKGNETKKKAASNPATLAKPPPKQPGSLVYRKRYTAMIQGRAVRRTLNTKRMSIWVDDEDREHKEAVNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVA2</accession>
    <name>A0AAD2PVA2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS15001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVA2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="470"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1954409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="689" mass="76665" checksum="0DFA3E50F4E9550E" modified="2024-05-29" version="1">MSTCFCCGSSKRKKQEKRNNPRKAPTAPKKTAIHNRHVVHNNNNNNNNNSDDDAQAVKYWRQKQTPHDGLNNTYEISKHPPLHPENGNILHPSVTTPTKAPRASRSEEQGSTFERFQPTIQCGGLVTSLSQDDEKRQQGQNLQIVSQNESFDSGIGGLDPYSTPTRPTVMSNEEKRLLQLDPFTCLDTSLLPGDDEFNACSDTDFKKEKGRRQGQRSQIVSSGMDENGSVDSGIGVEPYSTPTKPNVLSNEEKELLQLDPFTCLDASAIPGDDDFNACSDKEFNAFGTPATQATAPLSPMEEEEDHLSDMGSDVSFDTKERYLKACRMLKDGLVNKRLHKSDQEFILALLRDAEAAGIGEGSGMDTKQISALETAASRLESLPNTTAQSAPPTKATKTKRKKGGLLSCGPKKIEEVQEPSESAFPEVPIIPKQRQDKGLVRFDGWAAANADIEYPFQILGAEQQEELEPRVLTPRIMEAMRGFFPFRVSESNFWLKFSLVRDGASLATLLESIKASTYTIIAVETTHGEVFGSFNGTPWKRHTKWFGSGEAFLWRLKKSRMTTEEQAQEADFENEMEVFPFTGYDDMVQYCTSRTIAVGGGDWLDHEFPFENEPRGIGFMLDGDLAGGETNSSATFANPRLCKKTTLSNEFAIQNMEVWTLTPFDNEEEAAQLEMHKLFLDYNARKGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVA9</accession>
    <name>A0AAD2PVA9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001862">
        <property type="protein sequence ID" value="CAJ1954259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVA9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="169" mass="18810" checksum="2DFB72FCD2514E9B" modified="2024-05-29" version="1">MMVALGFGFECLTAIDSRLVTAQCCFCFVDDTDVIEAGTSVDQSGEDICTSVQAAASTWAGGISVTGGGINPKKSFWWLIDFVWDARNGRWKFRRKNQLLPDYHLQIPGLSGKQEGLRRLEPDEAEKTLGVVLAPLEDPKAHLEYLKGITKKWVEQVRSGHLHKYDVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXX9</accession>
    <name>A0AAD2PXX9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS23446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002413">
        <property type="protein sequence ID" value="CAJ1968890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXX9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="87"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1968890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="381" mass="41385" checksum="75D98BD4F6AA6DB9" modified="2024-05-29" version="1">MSEEEREKVQPEDNKSMTADANGSDTDQASEKDEGEIPASDAIADIIANGSSLYLYRDFSNVAEAELEDVPASSPPPSRAGVETSIRVQKFPVKLYAILAQKEFNEIITWQPHGRAWKVLKPQAFESLVMPLFFEYSNYHSFNRLVNAWSFRRISSGPDRGSYYHELFLRGKPHLQKFMRRLPKTHKKLPMKKEDEPDFYDREKITPLPGLDESQLPVTSIISPMKRSMAGSAGIRPSLTGSLPAGTPGLGMRESLEASREQLLNLNPRLGLNPQFGALAPFGGMSQLNSMQALGRLGGMGALGAIGCLGGGLTSFNPGAALGPPGSQGIGAALRASQLGVGLGLNNPGFMNPSNNPMDLRRLQELEAMERQAFGLGAANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CA49</accession>
    <name>A0AAD2CA49_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1895413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CA49"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF2">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1895413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53505" checksum="E5B722F7B0A24B2D" modified="2024-05-29" version="1">MSQTNADQGDLEKLQQALQQVVGKFGSIDDVLEAFGLATLPTAQRYGVLMGCIVFATTVTAVIALLIFGGSFKRIAEQEQTGEATLESDFKARKGRPLLLERLLKARKRLLAENYPDREQRKTLRTNLTKMLMSLPPPKDIPGVVDDVEAKQSVNKKKDRAAEMVGFKENFAWAYRKCQDQPGGGIIPGKPEARFEAFARGYASCGDNTTLGYRRSYARAYESVCCANDSTEEKFSKLYNANPEALVGQTVRLEALDSSKHLKAIFASTSGDMYFYKKSYDANEVWGFLEEGPFNTQEELKNSFVFQQYENEAAFAIVQNLNDRVLGVAMVSRDNPKHLSIQLDPPIIGPSTVGTKEQLESCFLLLDRLFANGYRRIQLSIDSKDGKGSELADRLGFTFEGVLLKDMVVKESNRDSKVYGMLNSDWDKGARIALYRKLYGGAMARADLAFNKKEEELTDQQRVLSKKEKLQASAKDKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CB40</accession>
    <name>A0AAD2CB40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1917194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CB40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1917194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="604" mass="67985" checksum="84C289C8ED16D924" modified="2024-05-29" version="1">MSSRVERGQGYEQGRGNESNFSNDRLSQNEAVASLRMFVWCCFFRIVNVLYIQSQFDPDEYWQNLEPAYCGAFGNCDGLTWEWKRRSNITSIDSVSDFIQQGSKGPIRSYVSILPTFLLYHVAKKLRIDSTWVISRGPVFLNAILVAAPTDWSVWYMAKFMTKPEGKEQMDNSRLWYLYASLTSWFNAYALIRTYSNSLETAIFSMSLCLVSPALLGNKNNVPLKWSALSFFLGGICCSVRFTCLVCYIPMGIILAMQQKTRSLFGFIIKACAFPGLLGVIVTLIVDRSFYGFWAIPFLGSLDFNVVQGNGDLYGTHPIYWYLIAGIPAMVGMLLPILILDLFSTWNKGKRNLWIICTCSIILHSCSAHKEFRFLLPLLPSFCLISGDRIFGLANTKRWGRTILEIGALANYVAIVFLGLFHQRGVVAVNQKIVDLVASNPKPTYIIHYLMGCHSTPLVSHLHTPPVKYQTWHLDCSPKCRSNPDEDCESERFSSNPAQFMEESYFQCTDMRKKVGACKQRRASPDFVVIRSSDLLPETEQYLDTMGMVPVDSFPNELSSVTFGGGGGTPLTSFQLFGGAITLQTDNIILFSETAIAIIKDNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBE8</accession>
    <name>A0AAD2CBE8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS68</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1891344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010190">
        <property type="term" value="P:cytochrome b6f complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021325">
        <property type="entry name" value="CCB2/CCB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044705">
        <property type="entry name" value="CCB4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34943">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34943:SF2">
        <property type="entry name" value="PROTEIN COFACTOR ASSEMBLY OF COMPLEX C SUBUNIT B CCB4, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11152">
        <property type="entry name" value="CCB2_CCB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042270812" evidence="1">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1891344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="317" mass="34191" checksum="FE4A78BB314E7B75" modified="2024-05-29" version="1">MSQYRINVWPLFATMFLLYPIDGFQTKSQGLKNHQQSLIHDHLPYSVYPTLPSTSSTTACFAESSKKEGASIRFSGSDATLTNPLDAFLSFVASDVTSIALGLIGLFFVVGNRLAGLDLDTAENLTVQTRTDLLATFACGSVLLNGITKLDVTSALAEAVVLEGQALPEAELLDTDSAKLGGEKQTTMLWALDSLLVATPAKTAIILEKQQSSDGDWRMVARAGIVSSTTDIPESTPILKRVATPGNTKETYLPTLQALPGKTEFPYLPSNSQLCLLIPFDDNNQRVLVLGGNMAKSFSPRDVAWARIIAERMGNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD67</accession>
    <name>A0AAD2CD67_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1912937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD67"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022203">
        <property type="entry name" value="DUF3727"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12527">
        <property type="entry name" value="DUF3727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042170626" evidence="2">
        <location>
            <begin position="21"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1912937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="242" mass="27205" checksum="8362E3489272650B" modified="2024-05-29" version="1">MMMMIKSIVLLSILLATATAFAPVSFHQQKVPSSQQLYSNYEDNDNGVVLTRISEGDEGVPIPFLDVKGNSFIECYADSIATVEGVDYTIGVPCDYCVALCYFEGENFLPVELDDKLMDDIFPVAENIVGEEFGEELALQRTPQTLTLVGELDDDIDDEEEDEDDEDDEEEYNGEEEVEVLLTFEHRGTEFYLVRLLDPVLLVGKTDADRPDLRVLLTPEESDKVMPFLEDGFLKAHEDNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD88</accession>
    <name>A0AAD2CD88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000101">
        <property type="protein sequence ID" value="CAJ1929889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="258" mass="28936" checksum="B686982D58656680" modified="2024-05-29" version="1">MVQMTRRGIRTRLPNDFIPEKHTVLCGRGKEYTSSTGNQHLKSLVHKYLQPYSEAKSKVAKSSVVSEIMGQIKGLCSDAAFVKLEKDAWWEVDDAFAREKIGCMFRDTLHTKYRSSTKAKFARKKAKETKSRSDSSAFSLSSMADESVQSMVSTLSSSSAETCYSSDYAAEIFEQSCLMNAQKAEPTTFKPMGDYYSLLSSYLTFGPNQAVQQPQQQQPKKLCNPTDFCVMPMRPLSNSQPVQLDDIPDDLSGIFDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDE3</accession>
    <name>A0AAD2CDE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1916396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDE3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="5">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="445"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1916396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="566" mass="62345" checksum="DC4E725BF86C237E" modified="2024-05-29" version="1">MAVMDDLYELIQRRNRQETDPFIEIHQANATLLKQIDALKTKCNDLERELVIEKEHHPADSASNGGRGAVPQSLSLKQETKLREKLEKLQEELNEKLKQSAEGQSNILELTQEISSLKDLNVAQASTIANLKAENERKESAIDHMTNELVDAKSRTKLAEQQYTGLKDMIRVLQDENDSLKKENEQFSSRMVSEKEKMIDEMNKLTEMVDKYKREVDLLHSLKEQDDKRKSWFKLGGRINQEEGTDGDQDDGESRKFGSLAVVVPSAPMHTIQAHKGDASCVQYDASGTDLVATGGADSIVQVWDTASGQLRQTLRGGSSNSILSCDISNGVVIAGGSDKTCRVWNMRTGRMIHHLVGHAHKITCVKLFGSEKGVITGSADRSLKVWDISRQTYKQTTTLRHSSTANCVDVSPDLFTVVTAHLDGGVRLFHLQTGERLSDISGIHQGAVTSVQFHPKDASKVLTNGMDSTLKIVDIRTGTPIHTFSDVQFQTSYGWASASFSPDGLYVGAGSATGMVLVWDAESGKLRKKLSNHQSCVCGFAWSRGGTSGQQVASVDKKGVLTLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEE2</accession>
    <name>A0AAD2CEE2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000061">
        <property type="protein sequence ID" value="CAJ1928869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEE2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="379" mass="42910" checksum="ECEF70C7014CE272" modified="2024-05-29" version="1">MSKEASVDHFNRSWKEFTRTMDPMNAYKHSYKLNVDVCGAAFMSVVRKFKLLESSLNLDPEKIKSELCLFHFTPPPYKATEYKSVVENNTTITRQMDYGEDKSKIAARSPHPFFRGRLKTPEDFHVTMANFLKFVCFLKKDFNYKEMPFLVECLLSFAKILTQNAAKAWLCKHHLNADLMVLILNDAMTIFSSAATTASTSHFVPKVNGFKPLPGAIFDTIAMATSSAKNQLTSAIHSGNLLHYSVELPVMCLLCPSASKSKEQGAATCKRDFPSSEDSNPERKRNKTDANDAPGLIRWTRPGRPEQPVPPIELMHPRLNRMTTLCGHFCHVGRRCRRRRDSPLIHLPSPNTLPVNLQRDLKQWADNNPNVELTHALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFZ8</accession>
    <name>A0AAD2CFZ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000148">
        <property type="protein sequence ID" value="CAJ1931458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFZ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="455" mass="50922" checksum="A9829A762B260885" modified="2024-05-29" version="1">MLLLIPHFSSNPNFDLEKKNEDKAATTNGQEEKHCDTDSSSPDVSQQNTHDSSPESDQKTTSASALKDFASTVLPSVGITLKTLLIPRKEISSPSRSATDETHSKPSHVKDLNSTRFDNKDPRSYTPRYNFEDDSIWDNSNSGSSSSSDRQRTGDFFHGQLEPSDVTTVETDRGVVEITNGMNQLTLSLDIDGTNADPIERATDLPPLVELWYDFPSGNILLSVDGIATHKIPLNEVQQIVMGRSCYHARSFLFGRNLANCQVSLAHRPNVPISLTGNAQIRSKCFKDCLKAGTRPVKFMQIKGREAEKARRILSMRFFNWDKMVTPWPYDHKGKPTEEWEPIIPFLVVLDPLKPSGQNGGTQVYCNRQLREKRKVVIVVATEKFRLAKAVMKDLVKYDFESSAHFEVKTVSTEADFMTAMNGVRKKEKATTPQKPPSSETERQVDLSATPALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGX0</accession>
    <name>A0AAD2CGX0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="236" mass="26113" checksum="FCBC483E12ECED46" modified="2024-05-29" version="1">MADHHEAAFLSGSSHSSFSSSGSSSCGKISPHPSSLGLRRSTMDLSDLDSSSGLLSQKVSPSRHFSSSSSQMPCSGATTSTKQEPYSARKLPSRQKYEVKPKYHRGIEAIVQDTFLDTLQVIDVTTAFSNLLSKFFDKKKRDGESRSTDDAAHATIKNNERSNDAEETKSDDTYSPCQIHIANTCSDGDWDHFADFQDRIDEEVITFTPFATAQHKSKAKLDTLDEMEEEDECFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGZ6</accession>
    <name>A0AAD2CGZ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1915841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042201797" evidence="2">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1915841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="289" mass="32473" checksum="8D1AF6B858F9FB87" modified="2024-05-29" version="1">MMELLLLLSCCILQSKAFVHLDLLTKQPISQASPTSSISAGKGFGKSDDERNDKEPLKKSYGKSALSPNKNVIDEEGAMEFFFESNEEWKPLFSTIMADTPDVAASDYVKKSEASDAFEFNENTSPWKRLEGIPTDESDREVLAGFLDSMQQSLIEIPVDERTKDDENDLHFLEEGRRMLVCSRFHVVTGVGKGAIEKHDSLFSTCWNEITQLVQEDESDTGSLIVVPECEMNDLSLFADMNVQRPLQWLGIDHKFEVVSVHHGRPAIRLIHKLSDMAVDNPNNKAETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH71</accession>
    <name>A0AAD2CH71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS4015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dispatched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000358">
        <property type="protein sequence ID" value="CAJ1934675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF7">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="753"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1024"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1081"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1120"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1155"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1191"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="596"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1934675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1216" mass="135904" checksum="FEF7A11EC3599DF1" modified="2024-05-29" version="1">MRRFQEEDDHDNVQGLFPPAFDPQFDVEAISGISNLGVPPEILAALQGMGNQATAEDPGAMMAAIIKMQQGIMETIESMEDTTEEDSFNPADIFAGMAHLSGGTGQSFGSPNAAYSPEVVHGANFTNDSSKNESETPAYCSPNDFNSGMEVQSGPMEVQSDPGADMVEVNLADLEVPSGGKQNVYCPPHESATKPPPRPQHPTPTQEEPLEFVKLVIRFPRLIFGCIFSFCLVITVALYVKVLSKGNPFSALGKELDLHDIRSVQYDSLRMAVYETAVARNEMRTSSVVPPRQSEVAESTYWVFEAQNEQNVFADPQSIASMKDTFDIFLQDEDFQEYCVLNPEAECTPPLSPLRMYYASSWDSTKVQFVIDDLKDPKNVEKINSLGWCYAYGQNCDKAPANPRQQDIDFVKRLNEDVNNIMASWDMRGDLIADYNQATELAAYLMETDIFKPAVDFGYDKGFSTENLASKYSRGIVFWGSPLEKNKDGTSEKNRRKDVITGSYLDDMNARTEEQSYYFMKILIDDAILGIIVTDAMWAVVSLTLIFVWIRFSTGSFFLACAGFSEILFSITVSWFVFSVGFEIEYFPPQNALAFFIVAAIGADDIFIFFDAYNDSKHEPHILVDLETRMSWVYRKTGTSMFVTSATTSVAFAFSLISPLPSVQSFGLFTAMVICLDYVLVMSLFCTAVVIYHDRFEDRSQYGCCYPCNEIVPSNTTKAMQAWQTSSADEDTKRPFVSHFFQTKVAPFIKSRINAAALAAVFGFWLYIAAQSAVRLETTQQAEQFLGNDHPIQKSFSILNNEFPAAEDDVRLKVFYAWGVGEVDRDGVDLLREPNNYGKPTFEDSFDFSKQCQTDLATFCSTLRNDPAYEDSIKRKNGVGEINCFIEELAAYSVLGNLDDCSYVQSGQWKKEDWQVDPADLPRIMEAFLDEKSCFDENGRQTIGARYSSELGWDGSTMRYAAISAQTEVLTPFGVYPESVTRKEYDQFADIADSLGQTVSRSCQTPVIMSDLDRKFVFMNNQAIYAKTAVQNSIFGVIIAFLVLLLKTRVFHIALFASMTISSVLTSCVGVMVMLGWELGTIESILVGILSGFSIDYIVHLAHEYECSEGDPNKRIAETFGALGTSLFNGALTSMVASLPLIIFCELQFFKKFGIFFLLTISFSWLFANFAFMTLLAQAKIPVERSGWKQLGVLTICTFIGFSIGVRQIYVWTRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH90</accession>
    <name>A0AAD2CH90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48708" checksum="1CA456B8F640D862" modified="2024-05-29" version="1">MSEPNKCYLCGKPGKLEKLFRSCKHEPACHSCLRNCYVLQATHVCKYPLKCFHPECKLVVRNTQIERFVKTKEELQTYHYLHTKAKMHKVRLGDNWKEIIEILGEALGSIELCRCPKCKMLITKSGGCDHMTCVCGTEFNWDDTSRRIEEKCQVMEARKAHHNLRSVEAPSLYKGKNVPFLGMDDEDLFADCGSYSGDDDESSSTDVCAVDDTVVGSYDEALDLDSVPSDLLDSFPSLCLEAKEKSAVVSAASVEEVSVGTKTEWEQESFEVLELASNASDDSWTHFEDESESRSTVANDFQTSSQSTWEELSEVSSVVSFNSKTGISFLAVARAAPPNQESSNSWKEVSKAPKLKCPLKTITEHRDNGSSYHDSDADGQEHQGEMFDADFMFDGAKCGRGGKGKFMFKHQPKRKYHRYDQRQRSSARMRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHA2</accession>
    <name>A0AAD2CHA2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PS II complex 12 kDa extrinsic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1921434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHA2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042173992" description="PS II complex 12 kDa extrinsic protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1921434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="25988" checksum="3D2B8B5EE4832F11" modified="2024-05-29" version="1">MKLLLQSAVTYLLFAEAVAFAPASRYGYTASSFALEAAKESNNHLGNSIKAFGVAATIFAFNLATPSNVEAQDVFGGSSLQVAETIKTMEFSLPSSYDAISDVKKSSVDELSQEENLLTGTVVKKVPKAATERMTVSPKLTDEEKKAIEAQKKADKEAAAAAKAASDAEKKAEREIAAKEKAVAKAAADKEKAATKKAQSEAKARAEAAKEEAAKAKQFSDVEFVDTGLPSYGDSAKMRGKSAFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHQ5</accession>
    <name>A0AAD2CHQ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS1155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1925593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.290">
        <property type="entry name" value="Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023222">
        <property type="entry name" value="PsbQ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008797">
        <property type="entry name" value="PSII_PsbQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05757">
        <property type="entry name" value="PsbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101112">
        <property type="entry name" value="Oxygen-evolving enhancer protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0793">Thylakoid</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1925593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="187" mass="20169" checksum="27CE64344AD896C1" modified="2024-05-29" version="1">MIQQRTTLFAQVDEIMTDVCHPTRRHMILGGLAATLVATTSSLPAEAKYGTSTNMEMPNYIEYLIEKNEAGGNPEQALYKGADPTVLLKRLQEANKRLAEIPTLTEEKKWSQIQGLITGPLGTLGVTINQIATTDSPANVKDAAKKVKGDVIAIGQAAAKKSGPACTDASRLASRDLEQFVKLAFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI67</accession>
    <name>A0AAD2CI67_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000313">
        <property type="protein sequence ID" value="CAJ1933874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI67"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12622">
        <property type="entry name" value="NpwBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="280"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1933874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="704" mass="77804" checksum="B13777E70BE6053D" modified="2024-05-29" version="1">MGVGNVMQEHHRKKRKKDMQKNKQQRLKARDERVLTTKSVSSVQEDIKKLKIRKNLQPTETQKLQRLEKELKILKEAQSKQPKPHWKPQQTHSAPKLDNPKKSVYFDEKFNPYGAPPPGKPRLYHRRGGGVTMNMDEAIVPGEEPPPPPPPPPPPPPQQNNHRQANDNRGGHDRRGDHTRGARSPSPPRKETESQSTTIREERAKEVESTEEKNKPLTIPSLPPPSKAVERGRRGKVNADIWASNEEVDYELRANQVDLEADNIGEVKKKAAKKKKKKPPLEFHYQDMSGQVQGPFQKAQMREWMNAGFFPPSTKVRTSRKDIWLPIGEVQALEEVQTPAPSASANEPSVSDRIAALKGENSIQDRIAALKGQNEDSGEGDNVDNDELRDRIAALRKSLAAKAPQEAQVVNDDESSMPHNSTPAYPPPDDVYEEEQDVGPAYPPPDDVYEEEQVAGPAHPPPDDVYDGEQQAGPAYPPLNDVYDDEQEAGPAYPPPDDVYDGEQASGPAYPQPDDVYDGEQEGGPSYPQPEDVPAYPLDEQGVAPYTVDEGYGEGQDQGPAPYPVGDGPPAVAPYPAVDVPYPANDSYPTDMAYPATDTYPVSEGDLAYPATDAYPAVEPYPVADESDDIQGPQMGPPMEPPQKTIKVDKAVVAFLPSHLRKPKRKPAAAESEAAPKRTKVKAKNDKNGTEDDLDKFMEEIDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIC4</accession>
    <name>A0AAD2CIC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="301"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="461"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="643" mass="71644" checksum="D5FAC81E52B5121C" modified="2024-05-29" version="1">MRFKKRISLTHSTRSRRGKQPAQIVEPEPTAMPVDEARFDQNEWQWMETVEKALINWDFGGGSGREATSIEMEREAPEADSVVPEQKKKGRIRPMFSALRQKLRRKPKPLLNLEEDHEVPSTTRTMEEDAKEQNQKQPLLTYEQWEKFMDTVAFPEKSKPFVAIKDFVAVSREKRAAKANSRSVSPNDVVQENDTVSDGEDSKEDKMSLAQYLGTQSVDEESVQQMKETGITWEEFMDTVAFPEKILGQKYNTLLSFIAKNRVPPNDNKEITTTSTSPRGSFVIKDDKYAFDDEEDDDIRLYSMVKDFPGEDLGISLTVLDGQTGIFVSHVARSSKAAAAGLTPGMQIISINQDSCPTDLEEAEFLLESVEDGVQIFAQPGVTPGFVLQGMDALEIGKSALANIFTHVVGLENDISDDDSHKGEGDWGAGNGVATVRSQWRNQAIGSKPVNLKPKSGRTKHFSIVKESKSEVVGVAFVQTQDWPGIFVNQILPSSKFYGCGLKKGMRVVSINGEPCPNRIDALIRKIQSVTGSLELCVEMARDVVNNTLDCDSFITTTIVKRGGENPGMTLRRDRLKGGIFVKSIDPYSDFVGTNLRPGLRIMSINGHSCPKDVKDCMWEIQQVDGILDIIAENVPETHLRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJJ0</accession>
    <name>A0AAD2CJJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="127" mass="13573" checksum="AE799B56A5654A5F" modified="2024-05-29" version="1">MLSTDKLRLLNSSRVGAVLGVFFTPNSPPVIGFGASPVSTTFNGQDAVHRGAPKWSDCFDPTLIQQYWQGDMSVHTHSLVVSLSGQTRLKMPASQRDFVQATKPAMLVGDFSKVLLIPDGCGAPVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJK4</accession>
    <name>A0AAD2CJK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1995 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000535">
        <property type="protein sequence ID" value="CAJ1936001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018962">
        <property type="entry name" value="DUF1995"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044687">
        <property type="entry name" value="LPA3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34051">
        <property type="entry name" value="PROTEIN LOW PSII ACCUMULATION 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34051:SF2">
        <property type="entry name" value="PROTEIN LPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09353">
        <property type="entry name" value="DUF1995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041941576" description="DUF1995 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1995" evidence="2">
        <location>
            <begin position="62"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="380" mass="42110" checksum="4934F0149E6A80C9" modified="2024-05-29" version="1">MKFTITLISTGGLLLTTARGCSAFSPSSTQQLSSKTALFNIPPPSVDDIEGFKAYADRQNAPASFFELQSDCLRSAQLAIRDGFDLLEIEFPPLPANVLDLDDVSAYDVAQANLKLALDLARGFTKTSEKEQKITILFPDESEAKIGVESLTGQEDVGVVTDIEPGICISSLRRSEEGDDRNFKPEQTFLNLFGGGGKSGDVKPLNGTDVYIVLVASAQELPDIEELHEQVKDDKIPIIMYNLKLDVLRGDLGAPAFPPKEFQDRFLSKVKPVYYLRTRQYSRSTTKPPFLVNYQGCLFRAYPGQFQTLLDTGTGSYRRLLGSDIRPGLGAFKEQLTQALRDDGILPADEGSALNFLRTGYKTTTWWEEERKDASMDWMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJQ2</accession>
    <name>A0AAD2CJQ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000421">
        <property type="protein sequence ID" value="CAJ1934934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJQ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="103" mass="12005" checksum="841CECFFE076F348" modified="2024-05-29" version="1">MDFLLCMEDPVEILEGTLHIDIHAKHVRDVDDGLSVIGYLDDWNESQAQLQTALQTIETITDKKNSLNRDLQSVRDEFYHSIWGLLDFCLQRSISQSSVQWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK13</accession>
    <name>A0AAD2CK13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS77</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1891660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK13"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="96"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1891660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="414" mass="47024" checksum="FF5727660DF4CC9A" modified="2024-05-29" version="1">MMSKEDTTRTFLWEESTAHSSHDPLDCFLGDSSEVSEELSASERSQSDEEKYAKAGCYIKDRMKTILASETFCKLRESKEGLKKNEPVTRVNHSQIELGNLLGGGAFSNVFEIKTSLTNEIDPNTCVVKVLRKHVLDRTKLFTACAVGLLREGSILASLQHEHIIGVQAFSQVGPSGYATGRNDACFLVLDKLQEILSTRMDTWTKFQVSMFDRKRSKKNREFFCERLNVAQQLASAITYLHQKSIVHRDIKPNNIGFDAGGMIKLFDFDVSRIIPEEEYANQVFKLTKTGTKRYMSPECGLGEKYNLKTDVYSFAILLHQILSLVVPYCDLNMFEVKRKVMQHGLRPKIPMSWPKGIKQLLKQAWCTDISERLDMSTVHDNLQQELYKLQNYQGAKLLGKTLTAPTTKLALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKI6</accession>
    <name>A0AAD2CKI6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="28988" checksum="4AB28D45E6110C89" modified="2024-05-29" version="1">MVSSRCKKNLPSLRVDDDFMQEDDDYLPTTKKADVDSMTLKTSIPKSITCLTIEGSVVNAGETIEPDQAHLYEAQDDDDDDDNWEHPEETEEFFSSNDTEDAENMSQTSWEEISEVSSVHSFHSKTGMTFLDVARLATQNKIADANNQEMDNWVAIAKARNQETANEDPSLNKEGPLKNSDSMDDVGDMFDSQFMLDGAKGIRGGKEKFMFKRQPKKKYRQWRSKNQLGTMLSCGARMPENNMISDRQGNRIMVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLD9</accession>
    <name>A0AAD2CLD9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLD9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="325" mass="36665" checksum="F76FDC6BBA654474" modified="2024-05-29" version="1">MSGRRSMDHQDEEEEELFIRVTAPATLEEGYSFDVLVSGEPFTVHVPPGGVKEGDEFDVLYDRAPRYLRESHGRANYHHDEQEEEAGYGNNEAEEEDEDETHLSKDGNTLIAGKDEDDTYLTKDGDTLPARTLTLSDEEEVAGEDDKTIKTWFDEETGAPIGRWRTKLCSCWDVITQSTFWMACCCTPVLIAQLIHRFHLTWTGLVGDVADTQLSYNRIVIGFLVALGFWKVPGLGDLIMTSYWVFVVVYIGTQVRAHMRQKYKIPTTLPTRCLKRHEDCCCMTFCGCCATIQMARHTHDDKEYPGHGCTTTGLGFDAPPIMADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPD6</accession>
    <name>A0AAD2CPD6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12398</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14175</name>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17648</name>
        <name evidence="6" type="ORF">CYCCA115_LOCUS20722</name>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7444</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8612</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001136">
        <property type="protein sequence ID" value="CAJ1943804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPD6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1959227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1964624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="170" mass="19418" checksum="C8AC2F3C6FC1CDC4" modified="2024-05-29" version="1">MMLGIEVTPEQVLIYGFEMIGGSPTTITDDNFKEHNIGVFKAHFGQRPSTLFILWQDILNCTNKDLGLRPSDRSKEGLKRLLVAINSLASASGISTQRDQDDNLWHWVKVLWALEAKVISWSEKEYKQKNYGPGRKFIMNKLDPYLFTYLRCVTLPTMCDSGFSTAITFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQH1</accession>
    <name>A0AAD2CQH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS3370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CAKOGP040000280">
        <property type="protein sequence ID" value="CAJ1933579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF17">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP16-3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041975373" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="76"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1933579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="183" mass="19435" checksum="10D30080F531AADC" modified="2024-05-29" version="1">MRCLSILSVIALCASMVQAWTPVNGVQLSRQDMLKTMGGVAAGWMLTSIPSGAETTPAGVKYEVVKKGSGPKPEVGELIAIRFLAFAGSNKIDDIFDTPEPYYTRLGSGALLKGVETTLPLMVVGDRWKLTIPGELAFGPQGRKASAGKPRIPPNAEIVFEVEVVGLPGKEPELIDLIGNVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQZ0</accession>
    <name>A0AAD2CQZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="275"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="366" mass="41460" checksum="D664527DCDBCBAD6" modified="2024-05-29" version="1">MSSKSVRFAAPAASQNAKRSQRDADIATSDEKSKRVRLNEEEIDDLDDWKKEEIDGEEDIPSERELLEAKRKRRRERAAGVDADGRTQIDDSTSLATDGIQIEPFHMRREESDGAGYFDGDTYIWRKNDPNDEPDAWLDSLGDERNAVPSSKSILQPPKDTENTEDKPENLDGLTKEQLYLKVLPLINGTETVAQAVRRYGAVSKQSKLKSKKGDPSSTEDSKVAKSCLDDLTGAANALLLKGEVDIYDTRRQRILQVLSKHATVMEFPNKQQAPTDWEYKGNQDGQIHGPYTTQQMMGWMQAGYFVGLQKVRIRTIRKKTNSPEDDLMADLMDDDEKADSQEDALEKGEWQWSDEINMKNYLPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSE0</accession>
    <name>A0AAD2CSE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSE0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09279">
        <property type="entry name" value="RNase_HI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46387">
        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46387:SF2">
        <property type="entry name" value="RIBONUCLEASE HI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="150" mass="17061" checksum="4841ECA2C145B221" modified="2024-05-29" version="1">MPYYNRLIIYFDGASKSNPYGPAGFGWTLYEMNRQGNHGMRIANGQGYLGYHITNNQAEYEGLESALAYIKDKDIGCTTLHIRGDSELVIEQISGKYRVRSKNLIDHVKSVKSKLKSLETNFDDVKYNRIDRGQNEEADKLANDAIEQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSG8</accession>
    <name>A0AAD2CSG8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042105395" evidence="3">
        <location>
            <begin position="22"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1943219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="485" mass="53693" checksum="1467EFFF6241FED5" modified="2024-05-29" version="1">MQFHSILHFILLACFVGKSFAQEDDTANNATTQSPTNTIMSPSVAPTRDPFTFRRPLNTVQVRLLGTYSSFKQEELLDSLKILLQNSLYNAMVDYFQVDDESSEQRPFDQQPKVGKSILSIVSLEWTSTRFQVDGDPYMHILQASGFLGFSQYDYVLLHPQTILPLQEKIMAGDNTTNPISLSKLEFSLRRNHLYFQVLQFITVDDPDEEEDAPSQVPTTWEYDDDDDGDGALDGDDDDDEIINNITDLKDNSTINTGSDDYLDRDYDDDYEAKRLKKDSASDKTLVIALIVACTVSTLAFAIFLRFVCIKSNRIKNDRLLRKQSVADVSAGKEKDGIADESERNNEKENKTGDTILTVKSSGTISSAASSPTTSPTNKTNPTDIEGGGDTSANREAAVAPTTEGAQETDDETHFDSAREEEDSKSSASANNWATIIGETTKNPSELTAVGKEPPGWRLPFCSNISPAKKTNSKYFDMGGGLYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSP5</accession>
    <name>A0AAD2CSP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI inositol-deacylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="62260" checksum="629F2E517A87B668" modified="2024-05-29" version="1">MGNLLSGKGNCWEGTSGNKKVTFTDESTSKHIKLLFGCNNAEEHLEYVQEMCDLIADKHGAEGLSGLGLEFRYITDKEEDGNSQTKSDSMPFSSPSAELSLRQKLQEEAKKNQNGEYSIPIQDGGEPDHAPDHVSISDDSNSDDKTDLKKSARFQHAISELSSADSDDSAGDDNNDNDDDVSISDEEKDISYGVREMSIEPSEFFVPLGEPISRMGSDRSLQTATTMFSLSTHESRGSAASKSPDGIATKPSGHLLFHKSSNTQITEKNHQLFIAHGKMYDEVARLCTECAQHVMMKEGNLEWQSLGDGINAMVTRNRSFRRPLLLIVTGKGKVGAGIFSRRHLMTNGIETSTALPFVQRAIHRKMDVAVLDPNGGGGQNAMQCVQTSLERLFLDHGETDEEVYILAHSMAGSQIVRFLHDKTFDKDTVPKTTKGKGVPTIAPSNAQDSHIQTGMNFLQQIKAVAFTDSNHNINWTKHNRPLKDLVEGPSSLYIKSHKVHEDAKILGEKHHDCDFWKHRFGNIKTIWGGTHEHALTNYTGMEHIWEHFDEIMEQSGEDQTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT96</accession>
    <name>A0AAD2CT96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS4746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000469">
        <property type="protein sequence ID" value="CAJ1935416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1935416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="266" mass="30058" checksum="8F799184149EC3A6" modified="2024-05-29" version="1">MTSQSSTPRKRTIRGGSAAQFPGKLHDMLCYVEKQGLHSIISWNFDGRSFMIHDPEKLMTILPIFFEQTKYRSFRRQLNMWHFERILDGPNRDSFHHPFFLRGNKELCAYMSRDAKSLPAGTPLRKLSCVEQGMSVLQTSQPLQRMLNTIYQTRANNVVDEMRRGGVNSRASSSSPQGLALSETGNSQVCDQASFAGRSFFPLEITPKQPTLKSCVPSSQSLLAVNQNTKFQSGSLERDLDSIMSMEYQKNNIPAGILELIENDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUE4</accession>
    <name>A0AAD2CUE4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS10240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001580">
        <property type="protein sequence ID" value="CAJ1946099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUE4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="73"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1946099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="239" mass="26809" checksum="467158B26FA79BA6" modified="2024-05-29" version="1">MPVPPYHKPHYWEAAYQSFGPEDSVEWGSISLADLSKYEYQILEWDSSRPQTNATISTTLGKTLSVEPNGEEEPILMLGCGNSKLGEDMIQEGWTGPIIQVDVSSRVIESMSQRCASLITNGHMNFIEDDATELSAFRSGMMNCCLDKGLMDAIYCADELDQCRSILSNVNRVLKHGGIFAFLSYSRPEFLLPAIAPNDGSKPKWESIQVQGLESIILYRFKKVAKSERSKISTKEKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUY1</accession>
    <name>A0AAD2CUY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4209 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001580">
        <property type="protein sequence ID" value="CAJ1946098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUY1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025209">
        <property type="entry name" value="DUF4209"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039635">
        <property type="entry name" value="ERMARD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701:SF2">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13910">
        <property type="entry name" value="DUF4209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4209" evidence="1">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="484" mass="55100" checksum="06A320AA7E3552A8" modified="2024-05-29" version="1">MISEIRIPDVRRALQLLLLPSGLNLRNLVWHGFVPELPRHWLSVVVVLAIILQEDDHVKIENPLDKHDLDLKLVDGFESVFLYDIDVTRTTEAVLDWLPKTHHALWYLAIDWYKAKTKPVSTMAILIVLLESGLRQIWCRCNEKPDLIAVPTEYFVTLDGFGQRKKQHNILLHPYLLDNGSRNKLIEFLPGSSTALITDLFCSPGGPNIRGLVSHGSYDANLLEEWERHNDCDGTSENLWQTTHTVLVGLHLAASREGIDYQPVFSNSAVSEQLLNQAQVQLRELRDLQVDCQKYASVATRSIGDTKTIDVVPESFAAFRLLPQRRSWTADDVFFEHQSNVKLANVGAAQMLLRDVEIATATHKRELQEALNSLEESKDVGKRKQKRNLRIVESTHAAYSLYRFGMCVAFLHLKEQLTEGDKTVESVSMRAVERARMVISTFDTFLHSNTERAMKSLREYNTANKTREIAGVICHQIFQEDANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CW47</accession>
    <name>A0AAD2CW47_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CW47"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="352" mass="39582" checksum="71FFB136AAF592B6" modified="2024-05-29" version="1">MMKKYTTKAVVRVPSRTVSKQDFSNNFDEKLNSSSFCMKSLLHNVEEGLWDITENSSYCTESSYEEISVNSSDIEEISLSPSDSKSPLEEKKGQEEVIDSSTQATSLPEGPIISCCSHHSKVSDITDADYDSFHGTANNLKQEIAAIEYIVSKHRKYFFSKTEISNRLGRLKAAQDDMLRENSYRAQFGNRNTKKSRRKPRKPSRKHRSKKSRSPGEDAPKSSDGFVLALMQQSTQSLSSQKWIDSPSSVRTRKTSNSKEKGIFTTMRPSCRKHRPSFVSIDHAGQIIEEQPHDPSKTGNTKEPAESPLDAARMKRMGRKGNVSSFVSIDDHAGLIVEEFVYRPRPSKTGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXI2</accession>
    <name>A0AAD2CXI2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING finger and CHY zinc finger domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS7043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF53">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="241"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1940440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51256" checksum="C8700D95940F7F9B" modified="2024-05-29" version="1">MDDAMDVDQEMPVEQPNGYQRAQRRASMSEQDERQRRASIKAILADTSISAVERRRSIQHLMDGRRSSIGASSATSSTATGESNPYGYGPPTDSNPYGYGEAEPRSANNSDYGYEDPTICRPVSNENTKRAELTRPRCAHYERNCSLVAPCCGAVFGCRICHDESPVLPPLLIAKQAQQAGARRHPRSSSMPGSFTSMAPQLPEETHHNIDRFAVKEVICRACYTKQSSKANNCLSCGVQFGDYHCSTCNLWMSNDEKPYHCPDCGFCRVGGAENFQHCHDCGMCIDKSLYSNHNCKSGKYKSNCPVCQEYLFSSRSASHEMPCGHAIHWECFRQLAAHDSRCPVCKKTAETRERMMPTWNAMAAGVAMQPVPPELARVVNITCNDCETSEDARAWHFLGVQCRNCSSFNTVVDRIIMTGEEAHEFLEALQARQDLNATEDGDQRISRRRINRRRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXU5</accession>
    <name>A0AAD2CXU5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000979">
        <property type="protein sequence ID" value="CAJ1940924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="179" mass="20623" checksum="D0978A3F04C82FD8" modified="2024-05-29" version="1">MNPHEKGTTPMHAENQRIQQESNRAIQQLSEQMNLMVQSQPGAYQPPIPHTTYYMPHQGPAYQPTEIPPPIYPPVPPFYMYQAPQHDPKDDLKKQIEELQRKLADKENQNGGNRNKHGPFPPRTKRFHNNDNYCWTHGHDLPNTHTSATCKFPKQGHQTTATKLNRMGGSEKNKQWVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBV8</accession>
    <name>A0AAD2FBV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Prephenate dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS45</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1890271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13631">
        <property type="entry name" value="PBP2_Ct-PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059064">
        <property type="entry name" value="TYRAAT2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26213">
        <property type="entry name" value="TYRAAT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041918321" description="Prephenate dehydratase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="49"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="12">
        <location>
            <begin position="250"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="11">
        <location>
            <begin position="391"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="681"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1890271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="78687" checksum="061D21784ECE122E" modified="2024-05-29" version="1">MYAISKIHQGIALIYGALIVSRLQPAVAFSPQNAWSRKTVLSKTALNLRVAYQGEPGAYSQKATRELLGDQVVAIGRPSFESCFKAVANMEADFACLPVENSLGGSIHENYDLLFRYDLTVCAEHDFRVEHCVLAMEGVKVEDIKFAISHPQALAQCDNYLRGLGITPVPAYDTAGSAKMISEGKLPDLPLGMTQENTCAIASDLAGRAYGMVCLKKGAEDNDSNFTRFLLLGRKGIDQYLTKSTPSKTSVFFTLSDKPGALYKALACFSLRDIDFSKIESRPTSALLLRMLKFQRDKSGNYNDDASMPRFRYCFYLDFLSSINDNNAKNALLHLKEQVDYFRVLGSYPTNSGLVGPIADAVEELKGQPEVDLSELSLVSLPSETNELKPMNIGIVGFGSFGQSLAAEMKKSHRVSCMDQVDKSSDARRMEIDFYHSFERSKFLSGLDIVILAVPMTCLEECVKSLPSEELRGKLVVNVSPLLLPAKKILLDALQDFPDIDVVVSNPMFGGSIDPDTVTADLWDGRTMVSEYARVSNGPRCDRYEKIFKNARCECYNMESNFHDATIANSEFVTHLMGRLLNRQLLPPALISSKDYKALSAIGEAAEGDSFDRFFSMYKYNDKAKDYLNILRENLADIERQLAAREAYLEAKADMRKIDRQQLLAETRLLLQELAQGGTLNLPEAGSSSNDQQFPGDDGEASRNLTLDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDD5</accession>
    <name>A0AAD2FDD5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000102">
        <property type="protein sequence ID" value="CAJ1929936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="63432" checksum="847A9330EEE68DA8" modified="2024-05-29" version="1">MNDNKSSDFLVTAYEFLLGPAHNSNNNNSDWEQDENAWSGYDWNFSECGTTNPTPREHCATLFVKYRTSGDVDAEKSKNANYKNPNDDAPVTSAIFGPILNEDDDDNDLIRIYNSSSNLNNSDDAVAAAEKGIDDSNPTHNDSSNKPSQFLRGVAYPQEDLRNVSNVNDVSTTPAGPEEEEEEEDLITIPSWTMGVFHVATKQDYEFACQLEKEDPFHRVVLKHEQTSHSISPNLLYTADHDTDDDDSSQATIMVCVTTGMAPTAVSPDDHPDRFLHQRVSTRIELKTRMPLSDHNDNDTTAITIAKCHLSYRDDQWDPWIGPCIEAMSVNPQYRGHGWLWVLWYQAVFPFLQQHYTVVEDNDASVDKDNDKNIKSTSIQVRVIHLLGSELDHYYHSSSTAAALSASNNDQDNKKVIVWDQDFYFGQIGFSILPRGERTGVMNYLRPHDDQGIGYLSLKKEETKGGTTLSSSCSISSSPHHQYHHYEAVAGARNCQTCGKITKECFACGKKCGGRVYYCSTACQETDAPFHARWCGLTRNQLHEVLVQEGRRVQDSKGEWRTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDK0</accession>
    <name>A0AAD2FDK0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDK0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="534" mass="58971" checksum="21E8255A940B91B0" modified="2024-05-29" version="1">MSSQDSIHRQFPVKKNRMGPFLGKQQSSRSLLTYGEFDEDEETDLVVPCVTQDEEDEVAQPSTLPQSSEFSLQDDTATEIWTEDESLGENSRSEIEAATEQLESRRIGTEHDRENYGVEIYLNHYEIMLQRQEDENVATLTHLKPMLEVLESLVKGKASAQIANSNTTCYDRTTLLREFRPSELKKAYKQLKEESTRFDFIRTDRQFMLVLRLLSQTAMAHQSVSWAEIAHCYKICVSGMQTLEEIPAGRMRNQIKERTIASLQGPILPKVPTSILKQSSKPSALTSVSTSSSSSPTISPLADMESKSKINFQDGSKSDRIVTKMKEAHETDVKEINFLKLTIAFLLGLMVSVTIVSQSNGSSPETGSLNLLLEQLSEAKAVAAEASISAAFESTVPMAVRTPQPQDVHFQPKEADIQPIMEEENKGEKTQSIRNPDVLESDNLETALTTFNAPKSTSTILFPSVSTLPEVRTWGAIAVATVVAPAVLQAAVALASTSLLIPMAISMIAATSALEGVRAVVLGWLKNLRPMRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDT9</accession>
    <name>A0AAD2FDT9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS2170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1930957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDT9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1930957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="135" mass="15632" checksum="219BA96F0C43CC02" modified="2024-05-29" version="1">MQSYPNVHFKDNIIERMGGSSSLNMLVVSFCENIKDDPSLAQYFGNFAFKDLSVLEEELLMAALVESEGENDIQSRRSRVALRHFRLFESGLNEHHFDRISKHLKYALEDCWAPEDVIQDCGRHFAGLRPLFEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEU5</accession>
    <name>A0AAD2FEU5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000480">
        <property type="protein sequence ID" value="CAJ1935541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="174" mass="19942" checksum="D9127A35991B850C" modified="2024-05-29" version="1">MKGQRTGHQVLNLNTKKMISRPKVVVLPVTNQVIQHVEAWTAAKEQGYLEEVFDQDYEPEDEDERDFNLRGQFDDIDDSEREELLADADNDVDDMPELTVRFQGDDDYESDEDLGDEGDEEEEPIVADLNHHQENVDRGTDDIGSLVTDLEDLQEPPKEEIVFEPEEPQVAKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFZ4</accession>
    <name>A0AAD2FFZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000469">
        <property type="protein sequence ID" value="CAJ1935434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="239" mass="27084" checksum="FCFAA8FF6EA5B0ED" modified="2024-05-29" version="1">MVAELGQYVHAIGTDSNNSMEPRSIEAIYIEPTKGQQRFGDFQDGDQIAGVDDTEQGYLEEAFDQDYEPEDEDERDFNLRGQFDDIDDSKRNELLADADNDVDDMPELTVRFQGDDDYESDDDDSGDEGDEEEEPIVADLDHHQENVDRGTDDIGSLVTDLEDLQELPEEEIVFEPETPQVAKVTRSGQTYAQAWQRLLLTTNGHRSGVQDFWQGMELAKKIGTSSASHHYCQQYSRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGA7</accession>
    <name>A0AAD2FGA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000049">
        <property type="protein sequence ID" value="CAJ1928508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="236" mass="27257" checksum="B2280236390B962D" modified="2024-05-29" version="1">MFAHLPRGFYSNMRSITGERTVLHLKKSAYGTTIAPRLWYKHLMKAFHELGFESSSYDKCFLIRKDMMIVVYVDDCGISTDKPEKIDELVNQLKEKGFDLEIEGDFETFLGVKIRQMKDGRYHLLQEGLIKKVLEAAKMTDCSPNHVPAAPTPLGKDPNGEPWSQHPWRYSSIVGMLIYLCTNTRLHWVVQRKNHQRILYRQPKNQSSDIDDELPIVSNKFVLDVTVKRSSNALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGI7</accession>
    <name>A0AAD2FGI7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGI7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="12773" checksum="FE980EE96050B4D8" modified="2024-05-29" version="1">MANNLLCAQILSVIAFILSLAGWWLAWVAGLIATIILWIACCCGLPRLVWVAVSVMAVIAAIGEILALAGVVGGDRIYCGNDSCGGPVGTIIIAVVALVSWVVVASVAWRQGEGSGKTSHDLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHE6</accession>
    <name>A0AAD2FHE6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000957">
        <property type="protein sequence ID" value="CAJ1940783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHE6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="102" mass="11711" checksum="3BCD70985627DF80" modified="2024-05-29" version="1">MFWSSSWQQVSPSNERLLPEDKMARLLSSKHLREEVGRAIGAPDALSPQTTWLRTKIREVSMTRTFTRVVAKAHVHISGDLTKQVLLENYILDQNDEFPAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHK6</accession>
    <name>A0AAD2FHK6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">subtilisin</fullName>
            <ecNumber evidence="5">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS6430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041991612" description="subtilisin" evidence="9">
        <location>
            <begin position="27"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="10">
        <location>
            <begin position="447"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="721"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1939105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="786" mass="85407" checksum="9CC654130C85FCF3" modified="2024-05-29" version="1">MLKPALPSVFLVLFTIQWFCVYPTQSTSTRRAAATFNDPDFNLQQWAFEMINLYPVWEKGLFGKGIRIRVNDGGVDPNHAEFQGRFDIDASCDKYEPYFYREDFEFGQHGTVVASLIGASGNNSQCAMGVAPEVTISSCVVIEAPSLDRTFGDGSYPAFKLDTFDISQNSFGRTPCYPTFDYNFSGTFADIMECPFLYRDNEDYIFEGEVYNLTHPCDVCEFPTSNPDEVCSFAIYEHCDAYFEKEQDECLTILDEYITRGECSFWQDYDRVSEAIEKGATEGRGGKGVIYVYASGNNFAYGDNTNFQQQGRFIIFVGAVGKNGQHTLYSTPGASVFLTAPAGDYEDADTLIAAYAGGGCDETGVGTSFSSPLVSGVIALMLQVNPDLTWRDVQGILAKTSRPVNHTIFDDTSQTTNGAGLTHSNLYGFGLVDAMAAVTAAENWTSYGEEQLITAKVTDLNLEIGDDPSVPVMSETFVESSGPRVIVENVEVDIYLEHLSRGHLQITLTSPDGTVSELAPGSLPENGQDDRPWDFRTVRSWGELADGVWKLSIVDNTEGDVSTCADMADWKVLEIPFGIASPVGCEYYEVRGALQDGANVDKVNSLIDQDILNGCCSCGGGQQVNGACESSAGFNATCAEVESEGICVNGSPTGAAEFLLRKDPRGITMREACCVGGGGTIYNDASTFQDILLGWELRIYGHEGSPAPMAPSIVPQVSPTMGPSMATQRPTNTEQPITIQPTSTVPAPRPPSSDDVATSTAFRQSLSHYHWVCIISGMAALFLLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIA9</accession>
    <name>A0AAD2FIA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS7481</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIA9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="242"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1941357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="486" mass="56159" checksum="89DBDDD490B3DB94" modified="2024-05-29" version="1">MLDAYYGRCTIFSDKVKSIQKLRQQKKLSKDDKELIDARCTVLMLIADNASEHVFRKVVPESEMKCWLTYAVSEMKRMATDPNWMATGDLEEYDDLATLQARKGRNNRMPSQYISLLVVRIVFSAYNIARMRFDSNWNEEKVFKKFESSGILEQFLRCATFVDDNRGLVQFLNQLQSCVNFLHKKFEKGKPCGDVLIAILEGKDGSRVKRPAVLNQLEAISRVVEAINISKKEKKTKMTKMCRHCGNSDPSDAFQDSLKSCARCKNACYCSKECQRADWKIHKTTCLPAAPKPEMKQVDNMERILSNFARKYYVLIMAKMVEACKGTDLKKKDVLIELDYTANKHGIVPAMQEPPVFAIVPIRHYIDGSRTNWFGRGHDNDPQFRQQMIAVMRDNLQKMKSWHLMFFVNFNGTTTCGKLDIERMYTGEVFDGFHSAIVDRDLGPLRRIMRPEYFEFVQGFMLLNYGIGEMGANQTERFWTKFASTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ80</accession>
    <name>A0AAD2FJ80_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001225">
        <property type="protein sequence ID" value="CAJ1944645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ80"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="683" mass="75278" checksum="E728125054503D2A" modified="2024-05-29" version="1">MTSFPKFFGPESPQMGTQFLSSVSICFSDDSIHQAIHDKKRPKKSEIQASFGFAVPTGKPYSVYGRGRKDSVTAETISADTVRFNAPQMLSMDKLRLLSSSRVGAVLGVFFTPNSPPVIGFGASPVSTTFNGQDAVHRWAPKWSDCFEPALIQQYWQGDMSVPTHSLVVSLSWKTRLTMPVRQRDFVQATKPAMLLRDFSKILLIPDGCGAPVGLYWPTSISFEDFKTSLSGHGTPYGSFLELLRSQSSIFEDWFTAVNSSAVSYQLQTTSAMDLWETLPCLHGDGLLNVAAAQPLREQFARYAIRQRCQVGAWLERARQCYPPALGYHSPPDHFAFLSVLCPPEDGWPWPEFSTWLSDLPFDALPDRYQRYEPKEIPVKARAVFVPAILVEKADPDSDLDAYANVFATTAPTVTATPNIAKVPAPAPHVATPSPPKEAPLPPVRRLASPPSVPQDVLGAMQKVRAFQETIVHGTSAGTPANPVDLAAGDVEEYAIRPNDLATRFASLANDSSTTAAMRAGNIADRRRSSLAQGRFGSGSRAGSLGLAPMRNKMFNPQTLAAALGVRQSRFVSADKASLASVQAHRTCSPYFLNVALVLASFFRQEEQPYLCLSDDRVVAATDWMKVPEPTQLLEISLQYGTMATRRQHQVSHEHCIIRFVFVRILLRNFNRSPFRTKLTLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJK8</accession>
    <name>A0AAD2FJK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="652" mass="74394" checksum="486ADCCA6508790A" modified="2024-05-29" version="1">MSSSSQILDKVTMISPASPGAASPKDEDFKPQQIVRSSENSKPAAVNQQSPMKKSDTRTLRFAQQQRIKPISNSFLASDKIRSALWYPVQELEERERQWKNETPNNEILKWEEGLFFLQMLDRSHMEAPQDDWSPKQEERVQRAINAVLSEQGRQNQQLQLQQLQLQQPHQQKPDPTPTEIGISAEEKDRLGKRDQTPLFMIAIQYSWHTGTAAGAAKHRAIQLAMEIQRLWQDEDTTATRKEEDGQDKVSIQDEEEKKEEKEVGKVQQMEDEPDSIEKEDTFEEESSVDLGNLPEKNESVSGRSLADGSDEAPKPVRPRGIFRGNSDHSALSDIGGLQKKGSSRSVFSNSYSDPLLDPEDYLGDWVHLALPTKFAGKEHPQISATLKKQRSRARLSARSLALKEDIQVSGTKMRKNNVLKSIHDRGAMALDKGGRKEAFQDCVKKLITLNRFFQSVEGVSKDRALDTDKKKFLEAIAAKKSNIFHSMEIPDNIHEPAEETKLANKGAPIQVHSILLSPAIKALRPKHKVVWGEKLHRVKFFPEFPLQFEKEEYFYTSEDISRFRFEKFMEDNNDEYEEQVMGSNEEKELEALNEEGDGDESSYEYESYEELSYHSDSDESYYEEELAEPVRDLANLSETQSVSSEGRRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK76</accession>
    <name>A0AAD2FK76_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001435">
        <property type="protein sequence ID" value="CAJ1945459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK76"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042018967" evidence="2">
        <location>
            <begin position="20"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="538" mass="57090" checksum="18679F70F6849A95" modified="2024-05-29" version="1">MILKVALYVLGFGASQALAQDLAASPEQIWSQQLFGATGGNAQAYSGNGLFLTPDGSEVVAIANGGKVASYRSSDGEPLWNHNPPGDDGSASFRVETLSGITFSTGNSESSFMVYSVTYKDEDSAGNDYTVVVKRDMAGDLLSVSPSLQGEHSGSPVVSDDGNYVFLTHNSPDKTTGYFTILSEALGLVVTRSNAGAFAPPGIYHSPEEGFYDPIPGTADGFLNTNDLIMWSLTPEAPNVSVPAGRIFGFQFATDFDIAAVDTLNYFNLGTDRAFQTITPPVITNKGRSAYWSTSRSEYFCFIGNPEVDRARFNRNPNLRLQFENNAQWNGQPIFSTPAVSTETDGSAVVFGGSASNEFFRFTHFFNGTDGEASKIVIETTPVTTATSTLIVTPPIIDPLGRAVYYVESDGTLHQANYDTIEDIWTETIPDGVQGEMAMNADGSILYVMSVEGRILALGVAEEDTSEAPTGAPVPTVPPVTSAPSIPPVAQPSGSEPSRSPVAAPTTGDTSIDETGESGAFTKSMQLAVVSLLFSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKH5</accession>
    <name>A0AAD2FKH5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="282" mass="31101" checksum="B15B6A6E2B3D9F7A" modified="2024-05-29" version="1">MSLPSRILRAAISRPSLLGRRPIANAASRVFLSTTSGGSTLAQLAKENPYKEVVRFEHKNRKWNLQHVDYYSDALAVGLLENGLQPGDVVLSWLPTHFSESMVLQFACSKSGLVLYNLDPALATADPEAAKEALSAALELTKANVLISQEAGSDVNYVRLCEQVIPELRIFDFAEGKPFVTPRFPHLRFPIHTGFDQDDKWGMLLFKHMVVPSDNLEEHLDGFTVDGSTPLLGELKLDSKGIPTGLGKVATNDQVTKSGVLETYSKILKREYHEVEGVGVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKI7</accession>
    <name>A0AAD2FKI7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase II subunit beta</fullName>
            <shortName evidence="2">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKI7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000008">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="32129" checksum="2D7C0808C5705823" modified="2024-05-29" version="1">MTYNEDSSASGHDEPWIQWFCGLKGHEMFCEVERSYIEDGFNLYGLRACVSNFSDCLDLILDRIGPDDSDDSHLTQSACTLYGLIHARYIITAHGLDAMYNKYAAKEFGTCPLVQCAGQPVLPVGLRDEMGADTVKIFCPKCSCVYHPPPIKSRSSHHGGAGVDGAAFGTTFPHLFLMTFSNLVPDRLPRDTTYVPRVFGFRVHVSARQRTTATSSGLLASSSARSNGSRRQIGIVRKSSASKADATTQVKAEAKVEDGKKSKSVKRRSSDGETGGKKSDGNGDSSTPKRQRTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN58</accession>
    <name>A0AAD2FN58_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001719">
        <property type="protein sequence ID" value="CAJ1946941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="312" mass="35114" checksum="AA5AFE7078B07DD8" modified="2024-05-29" version="1">MNVNDNEEKPFYSPQTKHKSSKADPTDKPDKAKVPQSEETISGAGNKTIKNNQLDYLNVVPYPDGRYYVYIRRNPAFYKPALLLEGMTAVDDFDPAANIHYAALNNEITRELAALGLTFRDVKNDNLPWVQIAEIAFEKEVEPFFLDALGNKVEKPYANGCSEDIIWTTKMKKEMNEWEKVDDDPLLQFGEEMAPFFVDCHGRHQDSYTLDTVEQTVSFCVRTLSLMKANRLLPVIKSKQKSPARSSTTRSRSTASVSGQYINTGFEDMQIEIPTEATTTAATAAPGFVPQMSPEEWAAMQKVIKMFGQSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNQ2</accession>
    <name>A0AAD2FNQ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001727">
        <property type="protein sequence ID" value="CAJ1947456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNQ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="100" mass="11276" checksum="0F34977AD507AFDE" modified="2024-05-29" version="1">MDVSITRQMVMDQAHHKEVIAAMAALGEEFLMRAATRDGEPDNEAYKKWSKQQIAKTEFQALKQALTATYVGLQQGMETDTKSTTGKTQHGPIRRRHDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNU5</accession>
    <name>A0AAD2FNU5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001735">
        <property type="protein sequence ID" value="CAJ1947633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="381" mass="42812" checksum="931C22C92EE05727" modified="2024-05-29" version="1">MALTFFSQQEWDRLLSPVLRTALPKAGICPRAMVYAPIALQGVGVPHPYGLQVIKHLDMLLRHPANKTKTPDAFLEAVLQAHQLETGTSYSLFQQVYANTSILASGTWAKRTWSELDSLSIHLEFDSPSLRPIRQGDQLLVDLFIDSLVDQLTLKWLNWCQIFLHAVTLSDIVNAEGTAITLKARKGLRADSFSDQYQWPRTARPSNPWWTAWQQWISTHLTGHSNRRRLSSPLGPWHSVDLSWKWQYSPSTNTLFHREGQLWIPSIPLASTSRQRTFYLPRCFNPDLPPLPVDAVCVLVSVFPSRSPIHKSRVLLHHSTGPHLPAEPPAPPSSILDLWHHFGSLAESGSHGWVPEVQSTILPPPAGVFRPLGCLQPPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQK3</accession>
    <name>A0AAD2FQK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001756">
        <property type="protein sequence ID" value="CAJ1948792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="162" mass="18266" checksum="E188824716D2692A" modified="2024-05-29" version="1">MKKWQAQLEAASTFKDDDSMVSDGSLNMQIYKSTLKMDSLKHCSQWTKDNKKPFKSNGSKHWDIDLGVHLDSGSTFSLRMNEDYAKPGTVSGLDYMFNYSTNTGQHDLHQQVESSIIEGHTCLLDTEAQCNLDSLSELVKLGFRVVMDTDIENSFIVTKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTB5</accession>
    <name>A0AAD2FTB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS12961</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTB5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07809">
        <property type="entry name" value="ASKHA_NBD_FGGY_BaXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050406">
        <property type="entry name" value="FGGY_Carb_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43095">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43095:SF5">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="47"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="336"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1951212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="576" mass="62338" checksum="FFDBE9110F87E26E" modified="2024-05-29" version="1">MNHRHFIASFSYSSFLLFILKISYTSHFVATAFAISSTGGETTKKAVYLGIDVGTQGTKIVAYCPQEASIIATASRSYDVMPTEVTGRAEQDPSSTWMPAIEECLMEVGHTLQLEQQDDNAEPSSYRIKGIGVSGQQHGMVALDSQLEPLRPAKLWCDVEAVQEANDLKDYFHSQQGQGNLDFLTPSFTAPKILWMKRNEPELYDKAKWFILPHDYVILKLANLRRPITDAGDASGNGFFLAAKRENSPIIAQAIDQDSKGEQSGESNTSVLEKLPTILSPNQVTGILDDYYVQKLLPWTASGMKAANIKAIPVSVGSGDNMCSALGVGCVSPGQAVMSLGTSGTIFAVSKRPPSGTDPSSLAPFCDATGQYLPLACTISCTGVLTQVLKEWTDFSSHEEASKYAASVPIGCHGITFLPYLGGERTPNWPHATGAILGLTSSNFQYAKDPAVIYRACLEAITFLLANALEEFPNKNDIDTLLVVGGGAKNPFWQQMIADITNRKLIFPLETETAALGAAFQAGAAASGMAVEEYVKGQAQALKRSPDTVQPQNHKAYEEAAARFRQFGSNLFDKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVZ9</accession>
    <name>A0AAD2FVZ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042273705" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13934" checksum="9B2F6D68AC64778D" modified="2024-05-29" version="1">MRKAYQIVFVILYYVASVSPCTAFVTQPSRHINSGARRTQQQRQSPRPVTDDSLFSTIILKAADKEEDQVVEVGSKEYLEGFISSPIQDESVAERGSGLEQALKLGGFFTIGLAVLFLGFMASNGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWJ2</accession>
    <name>A0AAD2FWJ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001873">
        <property type="protein sequence ID" value="CAJ1955002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="155" mass="17296" checksum="35F5462C29FF1F27" modified="2024-05-29" version="1">MGLDIQFSVHSNEGSRSLAKPHQLSNGYPMALDHDVLDIHDDDDADDAFIMDAKYEATSGAEVADKQKHLTEDQRKLLAQALKNTDEIFNGQLGHYKHEKAYSVLKQHEPVFLKELKHLQEIGVLERTGPSDGRRQHSAFQKRTVGCDGSAISDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXU5</accession>
    <name>A0AAD2FXU5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="330" mass="38265" checksum="9F5FBB04CAE71CC2" modified="2024-05-29" version="1">MIKDKELATEPTTATMDHHHDSHEEDAGEPKSPKRDTTKLLSKVKKPSSKRSLKHSSGASVSSGKSSKSSKSGKSSKSSKSSKTKLPSDVKIVKEAKKLAKKFDVEEKSFKAIVSLLYKRLNLTQDDKPRLMKKKKLIVSAMEEERASHSKTPKAPLEEKEVEEEKEVEEEKEEEEKEEEEKEEEVKEPDYLDPNFEPKSFEEHREMVLARARKEAEEEQEHHQKLIEVERLKAQAEMELQKAETLAKLRKQRLEREQKDQMREKIRQNSVEEDNEHFFAGVNSMNDQLMARAEEYKESLEDQARKGMIILRPRDDIEQEQERAKSSNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYB3</accession>
    <name>A0AAD2FYB3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYB3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="518" mass="57635" checksum="91FA5FC7E7067C91" modified="2024-05-29" version="1">MMTRVLPTNSEITSFPQPEDSLARDTTPENLLSQITSPEAHRKDSGDFTDTSGSSDGSIGSKKSVNSTDVWVQACEAHKDDPSSTPNAVAAETIGQPHTSTASSEATQKALDDRQQDQQPLTTADAEEGESSVDQQWYEDESTDLNSSSTFQKTNMDSRISSVTFTTGSVAPQSSSELFAPSINNETETPQTSSEFLKASGNKVVSRDITNSERWKNNNKSQLPQPASRKISFAPKQGDFGLPSIPKRTSLNSNNSYASSAAATTVWPTKAILKASVDEVIPVKIHRRFWKKLPPPEMNIIKEKRQQMLDFLQSQEEEKENKEVDVPSSTTATTPFPPPTGIHHRSQSDCTGTPAVALAPLRERSKSEGAKANVNFESIFVREYQQTIGDNPSVGYGTAISLDWPYIDHDPVDLDVYETKKKRRTMRQMFLNHYQRKNILIHRYGHSPEEVKAAKRATNKVKTQREISKMMQTSLQPLLLFEEMRESAVRKVKRRRNKGKNRSSDVAIVSSGEMLVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYV9</accession>
    <name>A0AAD2FYV9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001928">
        <property type="protein sequence ID" value="CAJ1956968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYV9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="216" mass="23743" checksum="7EAAF36A8C0496CF" modified="2024-05-29" version="1">MADRFQIPSSQTEENADPRQQPIEVDPPEVAQRTTIPQVQAATETPVPDVPNREPATVTQQDDDDQSVDLVASSEETDEMVTPDSVDTYLKYIAGDDNNMCLFDSIIGHKFWEGELYLKVQWRTNDVSIRDNKIIIISETLIVRMLLYGHSIAGEIFGCKGQVLWSARRGEFGALIVPRTLGSVQKGGGGGGREDSPEAMALSPQRATIVLALLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZG0</accession>
    <name>A0AAD2FZG0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZG0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="286" mass="32281" checksum="A1AA9BFF50DCC82D" modified="2024-05-29" version="1">MTLQDLKLRLQKNTAFKSELKNFDGDKESMDESEKTQATVSVEEEEDNTSVEQDPGMDSSNHHHEEVPTPPSTPRTPRTPRRSSLSSINKYEYNTFDEEGEVPPPSTPQTPRRHSSISTSTSIGTTPRRSSLKGSNGTPKGARRHSLTFSRDVVVATIVPTPELAKKKSLWFMEKDYEKMRKKISHIANKAQEKGGAGHKYCTRGLENLIRQGSETRRYAAWDAVLDEQENQTFQGAGKDEDALSQSYRSACEESRAEATIRALQDEKEVAEYLSETRNYCRRSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZJ5</accession>
    <name>A0AAD2FZJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041974224" evidence="2">
        <location>
            <begin position="22"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="514" mass="54488" checksum="4E32F2E2C6D8E9A3" modified="2024-05-29" version="1">MNLLLSATALLVLSAFPSASAQRYQYRWEPSISPAPTETAIPSPSPSDVPTTTMAPTITGKPTVTASAPPTVTNKPTDSPTESPAPSPSPSDIPSGSPSAAPSSSPSSIPSSSPSFVPSDMPSLAPTHVPSAVPSVSPTNRPTVTPQPSIPPTEFPTITSKTQFAETDYILSDVPGALPAKQLVTFTTVAKEVLQSMVDKEESAKIDILYVEVLDQVFTPANGERRQLKKGDENGILQIALKVAAEISPGDFAGFPELLDFIVLSTETDKVMEEKLKRAKDFYGFTPAAVEGSGSGGKEDVTFSNGALAGIALSCVAGVALLFYHGRKTHYRVLTRKRGSYDRSGEGILAGSNDDYSADAYGKNSYIPKDWDASSPQSVGDDGSKLTSFSTEAVMGGKPSSKRSFNPKKMFRRSGKQSPTQANEAILDDLEKNFSDSIQITHTTSDMVSRSSTGRSGMGRREPSAASDAAMMPPVMEDESGHSRGTLRSNNTLEEMTAIETILENPSDEQTRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZS4</accession>
    <name>A0AAD2FZS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS17038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZS4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1958130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="204" mass="23594" checksum="5B28BDC89944AB6B" modified="2024-05-29" version="1">MKSNFFTKRAESPTASGIQFPWKLHNMLDNAETEGYNAVVSWDGKNGFKVHDKDAFVADIVPKYFSQTKYRSFQRMLNMWGFQRVREGARKGAYIHENFRRGEPDLCNRMKCEKIKRRHTIPKTTSMNKNIDMNTLQGSTPKNKADVDLFEGMTFHAVEGVQEANLQDLRKIPDPSSRKFSSMDYLFLDEMLNVFDSGDEAPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0D4</accession>
    <name>A0AAD2G0D4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001957">
        <property type="protein sequence ID" value="CAJ1957787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0D4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="131" mass="14732" checksum="B3B2801DAEC3CA82" modified="2024-05-29" version="1">MGKSPAPKAASANTKKLGVAKSKASSVGKKAMKKQLEIDLEQPKDRDPVNSNDVVIKQIADAQDTLRMADEFEAQQIAERDARRREEYNKLVPKLSERWSKKLYSGEVVNQALQRMDRIQTGNTLFAAWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0Z2</accession>
    <name>A0AAD2G0Z2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001978">
        <property type="protein sequence ID" value="CAJ1958415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0Z2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="319" mass="36157" checksum="CDF51385A2FE3D22" modified="2024-05-29" version="1">MSLLAEPSSQSYLEHQLQNAKARELQWKAVLPFKGLIDHEDETVNLFDYVGKEQQWRRDHAIRFDPLQFPPTPIGRKELMNHLRVIACYHGSKFHADPKTGLLRCYRCRISATTNKDDPNDYDPCGIAADIRRKGLHNDRRNNRDNGQKRKRATTTAKDTTGNLLCRLKLTFGIHKDNALPGGGYIFLKCTGNNMHQHHIQPQNGELSIPANLLTKEQCRIIYAQQHAFVGGTQARKVLLELRHGFISASTHRRVIETAPDAITAKPGTGRSSASELLNWLRREASKPGDSKMSYCVLSYEIRPETLNLVSDFIRKPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2Y2</accession>
    <name>A0AAD2G2Y2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002074">
        <property type="protein sequence ID" value="CAJ1960838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2Y2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="235" mass="25101" checksum="3D3EC552D4A111E7" modified="2024-05-29" version="1" fragment="single">MGRDHSSKTSISDEKNKKQQQNATVMPELGEKLRLMNGSSHHSTESTSSSSRQHRSSSSSSARRHRRSSSRSSSKASHLTEMEDKMERMQPPSDSPSPSPSQESSPITRRSSSRRSGSSNRRSGSSNRRSGSSSRSQSGSSRKRSGRSSTRQRDGSKKSDDALNLPADVDPNLSDEDCTPGAHRVGSFGQVSTLSPASFEHNESTDDQSFSTASRSSGTSSVGAGATIRSSTTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3M4</accession>
    <name>A0AAD2G3M4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS19292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3M4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF30">
        <property type="entry name" value="OS06G0587000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042019387" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1961629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="89030" checksum="E86675EC916F75EE" modified="2024-05-29" version="1">MARITSLQLLPVLFALLNVADAQRKRNFVLEVDELMDNVKIEHRGHRGLRHEKPFHRALDGHMEMGKDTGKGMAGKGKMKMGKSNKKGSYDSKESELSSKKMSKKTSSKSSKKGSKRRGMEDPMMPEPPMDMDMGMDMGMDMPTMPEPATPVPVVPVVPVPPMEDEEDTPMIPPPVIVAPPVDSPPMEDVPATPVPPVFVPVSPPPPVQENPRTPDPPMVIPVPVTPEPPMVIPVPVTPDTTPDTPIVIPPPMIVPVPGGTPFVPIPVPVQSIAIVSQNEPAVSFDMDMDISFDMSMSMPIAPPVPSPVPSPTRRPTTPTPPMTPAPVPTTEAPISTPPTILKDCDTLSREGAMLTILVQITEGPIIANPGTPQGMAFRWLLNDDPAQIDPCTYITLTQRYALATMYYSTFGADWNTNTGWLSGSNECSWFGVTCDGEGFVSEVRLDGNGLVGDIPPEIKVFSEITIFRTRTNALSGPIPNVLTSMTKLVTFDVEDNDLTGPPVVDLTGLTSLQRYRASENRLSGSISDTVSEASALQQLWLADNLISGTMPTTLGLLTNMERLFLYRNLLSGTIPSEVETLTSLVGFQLQSNRLTGTIPEGLYNSAAMGEIRVDRNSLSGTISNELGNLVQLSDLRFNNNLMSGSLPPSLSGLTDLRILRVNDNAFTGTIRDSFDGWFSLDFADLKNNQLSGSLPGSIFEIPTLRIFYAQNNQFDSNIPPSWGNSPVLRDLYLSGNELTGTVPAVEVGQLGALTELILQDNQLTGTVPPSVCQLREEGSGALVSLWTDCAPEASPRIECDSSCCNLCFPNSTSPVLESENPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4J6</accession>
    <name>A0AAD2G4J6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="976"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1328" mass="154898" checksum="701C4494CD4EE255" modified="2024-05-29" version="1">MKASSLYTIGTSCIFLFLALVLPSKKAITWGFQATTRTGINTQRQSKPISGSALRRSRNQYPYPYRPLWYSPSSDDDRNQDSEKVKSGNQNKSNKSAVKNSKSSQNGQTPFNIFNQIFQHLGYQSKVDEIEKKDVESESQSELELESSPASSGKQQDRVARNAIIMPKQGSATEKVKPNSKIQKPNIKATMVSQKNSNKSLRQERVSSLTTTNAGNVTANNTAFPTHEFQQKLLEASLAQRQKDMKENTTLSTKYQASMKHIRVLAGLYNSTKVDATLPIPEPTNFKKRGRRERESAKKLVRKATAEMGKIVSKEDAAKRKKKAVKAANFTATTREQTKETKDVQLKKQQPQNGKRNNFNSTRPLPPRQNQDSTRRMRRLSQFQQRLLQARLRSEAKFKVSLAQRHEAIIREQRLQSQRQHSDFRRRLLEQTNTYDIEAIKRKRRLQSQRKHHNFHRRLLEQKNAYDIKAIKRKQKLQSQRRHHNFHRRLLEQKNAYDVEAVKGKERRRIVEERLTQERRGREAKKKQEFQFHQHLLAAKYQYIERAQKFKMKRLLQEILQQKENKRKEKEYKFQKRRLEASFQSMENQKEKEKQQKEKEIQQKEKEKLQKLNSMLQNFSLMNYTKKKIGEKSKFNFQRKLLEASIENTRITRRREKKNQSEKQKLKLQQGLLEQRLRSEAKADDSKRMAMAQAEFQQNLVELYDKMASFSKYEKDFAADEMIRQKQKTDFQQDLLSARIRNDLVARKRLAEKRINELHQSLLDAQRESELAAAQVLEAEERKHQAQLDLEERQKREDEEKEKEAKRIEAEQRVKQQIEESREREAAIRAVLEKAGRQQSSGESVKGMNEYEAILEMQRKQAIQNRIDEGKRRQDELQRMMENAGRTEASEQTMDRYEEILQQQRNEEMRRQQAEAQRRQEALRRQLEEAGRPQEESASTMDQYSQWVEQTNKTSLARPEPWQPPRATVATETTALLKSDAIRTGSQPSSVFQPEQAPTIDSAAISPSQEENQSQQQQLENQQEVDPLVGKVLLDKFVVAEKLRVGGDRSELYKCYHVLDKPQEYALVIKLSHNIQQIELEHRIYGDLFSRLSHDRQELFVRAYDWVPASDLTNGRVGFAMECGLENLRGHIWRHGPYNGEKLRTAMENVIRIVQSLHGFGVVWSELKAENFIVFNGDKIKAVDLESVAAHNEFLRAYTAETYPPEFPAESLYQCLPQIPVDYSFDVWGMGLTLYELAVGEPLFTLQRTYDVEYIKERLKNPEGIVDEANKKMWKVESGARNIIRKCLVVDPTKRSSCDELLQDPYFANGKQPPAIFSPSAMGNNSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G559</accession>
    <name>A0AAD2G559_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDAN1-interacting nuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS19832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G559"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029404">
        <property type="entry name" value="CDIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31661:SF1">
        <property type="entry name" value="CDAN1-INTERACTING NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31661">
        <property type="entry name" value="SIMILAR TO CDNA SEQUENCE BC052040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14811">
        <property type="entry name" value="TPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1962739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="344" mass="39347" checksum="CB87AFD5723FD764" modified="2024-05-29" version="1">MARKPKRKSKIKKKAKPPPVTEDEMKKQVSNRRDQMPEGQKRKSFSFEWASVPIPKTMETEMGRRVVKRGKYNAISDSDKEDISEYIATSKSAMTLSQAISLRAAVLQEKTMNRHHAVLGRNAKEITDRYQRGQGILSLSKKYDSPPVNLFRVILSGRGFQKSQIKQCFKNPEHHLNERDCQEFQKACREDVVSSPNCDKAHEQAERFETITEQFLKDLGVAFLTQTDLIKEQKPRYGKIVASPDFLLLDDVMVNGQYVRWIDCKAFYGANVNCRKKGVQKQTARYQEYWGSGAIIFLEGFSEGLLGIADCTCLSARQFMETRYFEPLSEQYAIEATTVQGDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G561</accession>
    <name>A0AAD2G561_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septum formation protein Maf</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002031">
        <property type="protein sequence ID" value="CAJ1959922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G561"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20961" checksum="6C795BCE5AB2F727" modified="2024-05-29" version="1">MMGLAGSYSCEPPPLDKSSLQKELVQQDLHPTISMKKLAEAKAHSLAAKHAGKERNTNIPVFYLGSDTVVDIEDKILEKPKNEEEAKQMLLKLSGQEHQVHTGIALYWLSSSCEISLLSSFTESAHVTFCNLSDADIDAYVAPGEPMDKAGSYGIQCIGGQMVQSIAGDFFTVMGLPMHQTSKYLARALIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5N5</accession>
    <name>A0AAD2G5N5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002128">
        <property type="protein sequence ID" value="CAJ1963077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5N5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29586" checksum="648203065CBDDFD4" modified="2024-05-29" version="1">MEARSAMHILNAPSTKSLKYAIRSGLIKNCPITKEAINHAKAIFGPDASTLKGKSTRPTPKKTYDDFFSPPEELYQHNRSITVCIDHMEIKNAKFLTCIDTTVRYCSCIPVQNLKTDPVFEALDKIFRRYNKAGFQVKTIKCDWAFIPLTDDLLDNMGVTIDPTAAGDHKPTAERNNRTLKERVRVALARLPYKVVPKVITECLERQAAELLNVFPQKDSISSHFSPQQLIDNVNMSISTTRVTWLLNSDSMFMQLGRIPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6S6</accession>
    <name>A0AAD2G6S6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6S6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="790"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1126" mass="119933" checksum="4FF49000AC0E5509" modified="2024-05-29" version="1">MKYSHQQESARQSNRRSVNSGSSRKGRRSSSRKSPDSKSRSPKRTSNDPNRTSKVGTSKEQDKEAKEKARAGRGSGNIATEMIVVGYSGTAEPSVEGGRRKHRSSKRKSQQGDKLAKKDATEKIDALIMNRLDEPITVAVPGAPGAHAASRGNPAAKDEKDGKVTTIDLSRVRSEEEDSRLHYVTTNDLEVTQGQVFTDAAPGTGVVNRLPRRSKRRSQQDRGIAKDAAAKINNLLDRSNQPITSPEPGAHAESRGNEVPKDQNLGKGRHSRPLGTQSVVSEEEHVRMEAEKVQEQGGLNGDGLVMANTVENHDADLAMALLNSMLDHIDEGNDTHGDKDTTGRDKSSDSREEENKEGENGRGSDEKDWEQSKLKKGARIFRYLCCIAVLAGAGIATWIALQANSESESKDSASGGVPSNVTTDMGTVAPSSPKDPSSTVNPNPNPNAPSASTGPSSDINIGDIIFEPPSPKDCAIIINGGAIPGQDSMPMQSYLLDLDATPFLPMDLSILAGIIEDKLRELLAPALTGCDRDLRNLRSTNRHLAAPDDGFSYAIGNVMVDAFGVEGVSCLDESNPQCHRIGSTLDIVVKDNGVKVATIITELVFFFGGGGLAEKLELAELYESIKVVNLGSIDQTGSPSISAPSAVSSPALVETSLPSESPTEGPTPKPTPPPTFAPVVGPTPKPTPEPTPEPTPQPILQPTLQPSPQPTLQPTPELTLPVTLRPTPFPTFAPVASVAPPPTPSPTPRPTPFPTLFPTLQPSATPSQSPSKSPSEAPSSSPSFVPPTAPSSKPSLSPSSGPSKQPSTAPSSSPTVSASAELCWVLINTFDFYTYNPELSEDGSTILLYNNEEKELRVYDTVTGNQIGNSISNINAYCSTTSYSIKADGTMIVDGCTGSWGSTGIVRVFKYYRDSWSQITTLVGEEEAQAGLDVQISNDGTRLLVRCRKDGAVLYYSLDPITGATSLLGTIDAPSNGAQMSGDGLRIAAIHNNPSGFAVGMGIRVYEWNGNSFSQIGSRLGYGPFAFSSDGNSVGFGINNQIFYSWNGSSWISRLFPNREINAVSGNVILTSVGELSQVFKWNGNSWVQIGDNIEESTWFGTMSSDKSTIASATHVYRLDACSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7J4</accession>
    <name>A0AAD2G7J4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7J4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="644" mass="70483" checksum="A7E554CC86E6BAE9" modified="2024-05-29" version="1">MVSTDVGEPLSKQEARTKASSRSSELIDSQDDDEEMGSCFTMESFFDSSMVSGCAIEETIAIEEEGARHDYEIALKDDSYPEENAASHEESIKSKSENRNRHNNRRRYVNRSRLQKTARPIRDAGEDMDDTIHTCHDSGMITEGDISFIIVEESDEEYEERTVEDFFGSSGDFTELEMTETEADIPEDDDIQDDAQSAGEFSLKLPTFSGHGYGNYDSVSTISFAFDDLGRSFSSELTDYDPIVFVTGGASAISRQSASTAQTPTSSSMMTEMQSTKPLSFTLRTQGTMASSIISTVPTAVAANGAMAPSGITTKELDRSNAIISNVTRNINSNRKKGGKHMPLSRNFLQPLSVVEGDSRSRSRSLGPINQRRRSRERRGGDKKSVPIRRKSLDDEDFDPSENDTFDEKQTDQTGQISSSLHNLKIGGPMRRVLRTKSSSKRIIRNHSGQVQKVELLQVLGESDRSIISHGWSQSSSSSPRLGRLQKVQLLGGSDQSIISQGFLSQSSSSDRLTKSNSSGRLSRSSNGCEPSRSNSSGRLSRGNSGSRLGSNPNDTGTARRMLSDAGSGKVLREDSNPMASGSYGGRVHVVPISVGSSNRRILARVNSAKKLVLDDQRRTGSHSRTGIFKIEEIKDSRSAKSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G885</accession>
    <name>A0AAD2G885_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS21672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002254">
        <property type="protein sequence ID" value="CAJ1966089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G885"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="6">
        <location>
            <begin position="270"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1966089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="545" mass="60036" checksum="3D9EF2D52E2264DE" modified="2024-05-29" version="1">MLQLQYRMHHDIADWASQAMYHGELQTHSSVRDRTLSQLEDLQKVASHGSSGSMDEMAKTRMLLVDTAGCEYFETVNAAGSRLNHGEANIVTKHVQRLIQMGLDQSQLAIITPYNGQVELLRSMLLQDYPRLEIRTVDGFQGGEREAVILSLVRSSDRGGKDGIGFLKDDRRQNVAITRAKRHLAVVCDTETVCQSKFIKNLIDWMETNGETRSAIEYAAGGGENEDYEADLRSAEAALLQMVESEVRSTEKSKTKSIEQKKEEKKKEDEIRRKALMDQISKFAEFGPLGKEMKLSTELSSYERMLVHELAEQLGLGHRSEGTEGVDRRIILSIVRKQGPEESKATSKAGGGKANDDAIDEGISANTATGPSFAALAIDDSDSESGDDEEANEPSKDQEAMATSTSDSQGNSLLAQLAKERAERQQNQGGSQATGVQKQQGGTKKKKKCKGQKLGGKKPVKHEPEESLDDLDDMAFLDAQIVKAENSHGRKVEGKGQYRTIVNGILNTRPEPRAKPTNPNANAALKSKLKDAQNARKAKPKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8K8</accession>
    <name>A0AAD2G8K8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8K8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40280">
        <property type="entry name" value="BLR6907 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40280:SF1">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31116" checksum="1E41D08AF736323A" modified="2024-05-29" version="1">MENVVSGKKTIWCNIGANQFHLPEGKPEAQVLDGVITLAYPDLSKLRERLQAAKSSLDGSKFGVKSASDGGVLVMDPWGSVFNLLRGDASVDQDSRGKQPGERSEGLAMRDLKIHVPENSNLGGIGRFYERVLGATVKDASEHSVTIQVGPSQTLTFQENSQTTIDSHVDLRNEAADDSEGHPIYLSNYGPHISMYVKDLPSSYKRADALNLAYVNPRFKRRAYTLEEAVDDCMFRCIDIVDPDHVEHGPIIKLEHEIRSVVKRDGSKYKSCPFDEIPAGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G987</accession>
    <name>A0AAD2G987_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G987"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="351" mass="40843" checksum="0AA81FBC32E5673E" modified="2024-05-29" version="1">MPLVISPKEHIKNFCLKRFIQYNRDWIDQQVSEYGAVLYRGFDINSAADVEEAVKALEPDLSNEYRGTSPRNAVNGSTYVFSAAEVPSHYPIAQHLEMSFLPAPPRRLFFSALQAPKTKGGETALSDFRKVYRDIPKDLREKLARKKLRYTRTHYRKGANPLFTNDISSLDSWHDIFKTTDRSKVEEIAAKENFPVRWEGKNKDVFVSEYQSEPFQLHPVTKEPVWFNHAQVFHWTTYPSELWNSFKRIRDIRLLLQCGKAWTMAFTTYVVFRRKMALTVTFGDGEPISIKEMGIIRKTIHRHMIFNRWQKGDILEIDNFATSHGREPTYDKGRKIVVSWSSALTKSNDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9R2</accession>
    <name>A0AAD2G9R2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 157</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9R2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042100766" description="Cilia- and flagella-associated protein 157" evidence="3">
        <location>
            <begin position="29"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1967001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="69095" checksum="9C4089804C4F3322" modified="2024-05-29" version="1">MTKNIPIALHKAVLLATLVPLLAPPGTADAFSAGVISARHENLPTPQHWPLHAQAEDESNGAISEPAFSPQPPDFPPVVDEQLQTDLMESERRIMMYEAEIKMVREQLEIKQDELQEERNFFRDEKSSLMGKIADFTNILAQKENELGELQKSQSDVQPSEAKMEKVNELVEEVKLLSSDLDAKTAMYLNQQKTTDELRKRFEQAQDNLEFEQMRFEKEKSVLQEAIEEERKNLRSMQQKMNESQEFFDTSKQELLDKIKSEEEKFQNAKATWSETQSMMEAVEQELRATIQQNEASMEERKKLENDAKDTLNDQLDEMRNNLKQEQSNAKRTVQELMDQKKQFEQEKNDLEDIIKKERNQIEKLRVGLIQEEQKFDKERIQLEEKLSSETEKLKTIEAELMEEKDTFSKEKEQLEKKLEQEIRVRQLKKRVMHDRYDEIRKEMTELWENTKRQARKEEARLKKKYEKKLAGVKKNVLRLEDALQESDATNADLTAKLLAAQEENKDLIVKTEQLETKYKTLLRNRDSIIDQQSMIIDEQTQTIERYESSFRVLAQLSAKVTGKKIRQIGGSVKRIFQQDTKTENTDMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB00</accession>
    <name>A0AAD2GB00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF2">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042181223" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="314"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="428" mass="48378" checksum="09591A2D8F3CAD1B" modified="2024-05-29" version="1">MKLSFVLAAAMAATASAFAPSPISFKSSGLNMAEEQFDQEQFIAESKEMRLKHLEEQAMFALKIACENYEGAVFPNAMIAGDVVITHLLHRLGYLEDGKCKVMVVDTFHLFPETMEFLKEIEEFYKFKAEVFCAEGIPVGDKAAYDKRYGADLWKENIEEYDRVCKVEPFQRGLKTLNTNCMINGRTRWQGFERAWIDQFENAPIGGGLAKCNPIAYWTLEDTFDYIAKYNVPHHPLHAKGYPSIGDAKDTIPIPEDGSTKFVDLKFEGDKTAWLDYASERKGRFVGLANADGSTKTECGIHVDGAEKTWDRDLWETDSSKVKKLETTDAAIEVKSSGKPSVMVVYAPWCQFSQKMEEEFEKFAEEVGGDVDIYSFRGDEERDFVQENLNTKSFPTVNVIKPDGTAVKYESEVRTVDAFKKFMDETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBG5</accession>
    <name>A0AAD2GBG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002402">
        <property type="protein sequence ID" value="CAJ1968770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="137"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="417" mass="47824" checksum="BF3BB016A961A510" modified="2024-05-29" version="1">MSLSSSSSSFPTNESVQRHLLSFQHAVDDSISASLSRHNRNDSSFRQPRVLYIDPHFYTTIENNNHDAGDAEESSSSSKHEIQITKRTRAAKKHLENSRQYRKWQRDPLREGDCKPMKPWQETSFPSCNKMHEMEIQSQFQVLTNGGYNTVYKFSDMDGSTRIAKILKYARDYTDRNLDRVRRDSLIMERATASDFVLDTYSYCGFSQLIEYGEGGDLNYWIMAVYERLSQKQKLQIATQISQALADVHNLDGNNISSMTHGDLASKQFILVDGKFKLSDFNRGRFLRWDEKTNEPCPYTIGSNDGKFRSPEEYDYIPQTSAIDVWALGSVLVQLVTGEEAWDGYENEVAQSAIVAGKLPPFREKIKYPSDPINQVLVKAIGMCYVYEPKDRPKAGAVVEYLKNEVTRLGFEWNRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBR2</accession>
    <name>A0AAD2GBR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33373:SF34">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33373">
        <property type="entry name" value="OS07G0479600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="31"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="162" mass="18119" checksum="82F0EDBD4B396F0A" modified="2024-05-29" version="1">MSETNANTAATTTTQPAALVWARNPEEEAAAAAAVIKAAEEQKQREEEEAKDEGNTFVNHGFMRWQKGREDWHAEKLKRIQEQQERKGGSGGDGNSNNNTMPDHLRQSIPLDVDEIIDIIFSPRWRMAGAETGPPKRFPQNVPLVQMVDVLVDLWEAEGLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBT6</accession>
    <name>A0AAD2GBT6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002413">
        <property type="protein sequence ID" value="CAJ1968934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="556" mass="63346" checksum="BBFDF06ACCCA3AB6" modified="2024-05-29" version="1">MKLKVSMNPCSGQRIFRLLVLVVIVAVGLTLQGTSIARVQSDLKLSLLDTVAMVKENIPSVLAEGSEEGRSLRAVTSSPTTSRAPSPQRNWTKPPKDHSEYTRNVERLHRAVNASLEVSSTPPTPSPEEEKKAKEAHIALREQQLVEARERAYQKYGAPIETPYFNASVPFEHFSHIKYYGFAGLGHRLARQAVAMYLARRMGFACRGYWSRTIYSNKTTDLFTEMFEPYTRDDFKYVNSTGKHVGYSNEVDGAMGMVSSNSEGQEGPPCTCTNDEVQVHYDFYMSLRNKYRRRDRIQAFMEENKFAEHIVFGIHIRAGNGETGDFTNKDRPINFDPKVFVLTVLKKIVETWPPDSLSKPPMIFLATDDPKYRMLILDQLEELGLSWPVALLEQEFMESGVLLGANRDSDVDQWHFMFQDMVILSYADVVLAIKYSSFTQSLPASIVMGRPLAERTIKDSFCEFIDVTKEEGSPVTVFANETAPIFEVHCYDQVMRWCCWNPNKTHKKALKFTTLEYQTQFPNMTVYNFAKNEYLSFETALGQTLGKRKLSYVKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHX6</accession>
    <name>A0AAD2JHX6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS13402</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="CAKOGP040001800">
        <property type="protein sequence ID" value="CAJ1952128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000826">
        <property type="entry name" value="Replicative DNA helicase Mcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="355"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1952128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="797" mass="87077" checksum="53D3C4AFBD3D83BF" modified="2024-05-29" version="1">MDFDESRLYFSHQQLTGSNEGGEENHEEEEVGASIDLQAVRRHFREFLRNYRLGAQKYIYREKLLRMQRRLRSNGLSSTESSTAKLEIDVAHLGEYDGSLLGYLRDQPAALLPAIELAAGDALKTLLYDLRKENLDAEADDDMVDQPIVSNERINQLDNLPSIQILLKGNLGFTPLRSIKSEHVNRLIRCPGIVISAAPVRSRATQLVVRCPRCLDTQTLVSTDGPFGSTVFPARCNGPEAGECGSSPYAIVPDESSFCDRQTLKLQEAPDKVPTGEMPRSVLVAVERSLVDSAPPGTRVSVFCIPTLFTSSSAGSKSIYLRVVGLSRGNQSGDGVQFTPVEEEAFAKLAKCPDVYDILTRSMAPSISGSYTVDIKKALVCMLMGGSRKRLPDGIRLRGDINVLLLGDPSTAKSQFLKFVSRVAPVGIYTSGKGSSAAGLTASVVKDSKGEFYLEGGAMVLGDGGIVCIDEFDKMRPADRVAIHEAMEQQTISVAKAGITTVLNSRSAVLAAANPVYGRYDDFKSASENIDLMSTILSRFDLIFLVRDMREEERDRMICKHVMGVHMDKEGGQPTSIDNSIVSPNGERTENDASAIADNVMRVAQTGRGELSVPAMKKYVQYCKIRCKPVLTEAAGKVLTSSYVKIRDDVRQRSVQAHQTGGDNAQSPIPITVRQLEALVRVSESLAKMRLDSKVKVDDVNEALRLFRVSTMAANSADQNLSDLSILVATSGDDVRCVQQLVVSRLAVGKMVNKQNLVEEASGLGYNASIVVRVLSAMIMRGELIERNQGRLIKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIZ8</accession>
    <name>A0AAD2JIZ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001866">
        <property type="protein sequence ID" value="CAJ1954278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIZ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="219" mass="24929" checksum="5609A5853CCEA66F" modified="2024-05-29" version="1">MNLSKKSLQRTTSLFHWEYLSHSLQHLFPKPALESRPTPAGDGPGNEASSPAGPTTYKDFGWVPADLSPGGTWHQQRISNLRWASEHYPEPKDIFDDGLHRLAVHRQNYNKDGPSPKWLQLLWWEFPSEHWEELRTGARQNFLERPEPHIRPNAPMDEEMLEAAVQFVDELVGLGVLRHIDEGLKVLTNALLFVVGKDGQPGEWRVIADMLRGGQNDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK68</accession>
    <name>A0AAD2JK68_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK68"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="13702" checksum="B03445DD09F97D03" modified="2024-05-29" version="1">MGAVPPQCEHVRSEEEPGTMAPVTYLLTRLVDVGSPSLLTISQTQDKKGKFKMAIQRSQQKVPTLIFFVNDESSRSLASLDSSSPSQIDVAPTMPKRKSGRSSFSSTSSHSKCDAPPTMPQRRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKZ4</accession>
    <name>A0AAD2JKZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="241" mass="24587" checksum="929D7218FE2F8DED" modified="2024-05-29" version="1">MINVQGASSTNPNENPNAGDGVEFSPDDLTYEDLANAAWTPLSGSAPDGSPAFIQMAMKSKEKGINANPYKEDYIFGKIGTCVGYFHITTKEAYAILSKRISARTKRFENDVALATCCTLGLCRGAKWKKKMDADIEILKITNSITEARSTAGAPFGKVGIPERYKDDKQVTSRHYSEAGAWLFPAAYYECGGGCGGGAIGKGNSSSKGGASACGAAACGVAACAGGGCGGGGCGGGGCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLF5</accession>
    <name>A0AAD2JLF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042111771" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="41"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="307" mass="33752" checksum="773AF1A29F8A2865" modified="2024-05-29" version="1">MLRLLFFIISLVTPSLSMISLNTIKGTGKSESSSKKTPVTILVHGLDSSSKTWEKTMPHLDGPSVAVDQRGSGYSPLGNPDNFSQSVLVEDLHQVITANAPNDDEKVVLIGHSLGGRVVLGYAATYPDKIAALVIEDMDIEERSPTSNGLVQLKPYDGVFDRQRNSKESLVQALKEVGYPDSFVERALGNGRLEPNAKAPQSSTWWSHISPDFRKLCYEHVLSTSQGKADCRTLASLFKEKKIDFSIHVLVAGKDGTVCIEESIQEMNEILGDEQLTIHRYPNAGHSIHSTEALKYQETINDIISKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM18</accession>
    <name>A0AAD2JM18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002142">
        <property type="protein sequence ID" value="CAJ1963375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM18"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1963375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="738" mass="83262" checksum="B0782F1D5BDFE380" modified="2024-05-29" version="1" fragment="single">MIISAVKARVRKTTHKYGIEIPTSVEHAKRLDAQNGNNLWMKALSKEMSNIGVAVEVLAYGVLAPPGYSKVTGHLVWDVKMDFTRKARWVLDGHKTPDPLYSQYAGVVSRESVRIAFTYAALNNLDVFAADIRNAYLQAPSSRKDYIICGPEFGLENVGKVALIHRALYGGKTAGRDFRNHLRACMHHLDFLSCPADPDVWMRPAMKDDGSEYWEYVLLCTDDALCVSMNPERVLRKELGKYFELKEESIGPPKIYLGSNVRKVELDTGVQCWAFGSSQYVQAAVKNVERYLNDRCKAGDERFKLKPKAMTPMQTSYRPELDVSPELEPSDASYYQSLIGVLRWIVELGRVDICLECSLMSSQLAMPRVGHLHQVLSIFSYLKSHHNAELVLDPTFPVIDAAGFERKDWSTSEFGHIDNLKEELPPNQPEPKGIGFVTTAKVDADHASDTTTRRSRTGFFVWVNGALVYWMAKKQTAVESSSFGSEFCTMKLCCEYLRGLRYKLRMMGIPVLGPSFIYGDNKKSVLANTSIPDSQLNIPKKQKYKNNTHIQVLKTSLLVLRLHDFSVAKRNSLLLFASKLTMGKSKNNKKVAIAAKPVNSTALTQGRISFLQKSRAETAEIRSKKESNNLDPPIVNNNSDTEMEEVESPLKYNRIVQNMDSSQWNLQTLAYLCTIYRARGQRNNKKEVVFGNELFSAWENEPDFHWPCFVESPVLAFLFLLFSAGFQELGNSSGRPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMZ4</accession>
    <name>A0AAD2JMZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMZ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="306" mass="34117" checksum="273C749A4BBB1640" modified="2024-05-29" version="1">MLNYHEMTMDEAKDSPQKKKQFAVTCTIMGGVIVYMLMTSGAFQSVNPIQGKFPGGNYVYKYTARDYAASGGLGRAIMEDLINTRLANKQEIIPQYKLEEQVHHLYLENPAGRGGPRQRFMSGLVIPKSKTDDDTMALLMGLNDDTKKSEFTKDEQHILSAIEIYNMLPYETAELPPVDALVLQFPWTGGISSILVQSMKVIPKMHKLAAAKLNDGDQTVVISACSKDEQMCTHYAPLENVEAFLLGRPTTKDFNDALGKEEVVDWAGMKLTLDYAATKWKEWTGLKKKEVPAPVLEEEGEAKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP16</accession>
    <name>A0AAD2JP16_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="137" mass="15458" checksum="33EA270B0A0EBB74" modified="2024-05-29" version="1">MAPNLKRTQLLLQTVDLDLIQPVKAGFPTLTSEVAEQSHKVIVQASQQDSSSSYWEWSAENDAEISKLVEEESLSADNIVANTLRQPAAPASSTLAANDQYWDWSHAKTESVDYWNWPANNDEQNQKSIESDSYWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPG9</accession>
    <name>A0AAD2JPG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS23966</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="152"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1969941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="224" mass="25008" checksum="32E5CF246C706606" modified="2024-05-29" version="1">MAGEIATPNNTLYVSNIDWKIKKALLRRALHTLFTRHGKVLEIITLRRDGLRGQAWVIFEDVKAATAALHHEQGFSFFEKDLRLAYAKSKSDRIAKRDGTYVPKAKRQKADAAVGASDETAAPPPPSQEQQVPPAPADDEGQDDEVKAPPSHILFAKDLPSQCNEMMLGMLFRQYTGYKEVRIPRVGLAFVEFDSEPHATLAMERLDGFKLTTNDTLKLNYGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU27</accession>
    <name>A0AAD2PU27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1947691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="220" mass="24640" checksum="1385BE0E204D9115" modified="2024-05-29" version="1">MSKSSNKNTPKTPNTKGNGNGSSNAFKTPDSKFSEVTNTTIEFGPKHKVNLFLLCALMLGIGIIGGYVVFVFLHGSRCSTLMDAKQLTYSQSQQQIQERYLKSVEQYQKCLVDLNESSSRQITSDEGKHKNNGVLLEKHQDLMDRHQATVHQLMMVQSEHSENLVQQQTLSLNLERCEDRTRKLQNEKRKCQASKELMKQLVSECKSKEGAAAAATATDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUQ6</accession>
    <name>A0AAD2PUQ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="5">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS12921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUQ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="7">
        <location>
            <begin position="270"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1951134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="474" mass="51751" checksum="1C92B37636DE27CD" modified="2024-05-29" version="1">MTTTPEKIGILVVGLGGNNGVTMVAGFLANNQKLEWETGSAGRVSGPNWNGCITQLPPKGGGVGFQGRYPLADAMNAAIGGWDIRPMPLGDALYESRVLDYDLVRQVREEMNSMDIMKGVYDASFLGETQHATAAHIVTGLDSFFEKVEHIRKDIREFIASNKVDGATTVIWSASVERPAEVQFESADELLQSILDSKSDCDISPSIMYAVASALEGCSFVNGGSQNTLSPGMSELYEVAYRSKSEGILSKFTNVSTKPAYVLGTDFKAGQTKFKTAAVEYIRALGLTPRVIASSNHLGNNDMRNLTSKKTIAAKMRVKKDIFEPWQEDELDHQVRVMYTPMMLDEKRDVVEYTSLGFLHCPHTMLTYTRCMDSILCVPLMIDAAVWCDFFGRYHSSSSTVARATAYLFKVPEGGAKGVDPGFQRQMNELEAALAATVKEEDGSSKKDLLILLKQGVASGIITQEQADSLKAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUT8</accession>
    <name>A0AAD2PUT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS10901</name>
        <name evidence="7" type="ORF">CYCCA115_LOCUS13237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001718">
        <property type="protein sequence ID" value="CAJ1946924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1946924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1951786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="348" mass="37950" checksum="A558C630EAA679FD" modified="2024-05-29" version="1">MSDRDIAATFRQKVVFMKSWKPASMPSNRDRLELYALHKQSVSSDAPSSFPNSASAAEKAKYNAWRTKSGLSATEAMKLYLQESDRQIRVYGSSSNNNNNNIKQATNGPSAIRSSSASIASEDSTVSTPRGIAAIPLLCAAANESRTAYLRRISQTPSDAAWWARQEALCGENPSSVFAFPESLVIFLAKQVEALSLASGNNVIRAFLWPLHNSLLSLWIMAIASITLFDGVLKILKVLVWGARRTGISLSLIWKDLNLLVSSVHAACEPQQAITCRLVGLGLLPATYTVSLLDKGFPSVTLASVGLVALLTMNLWYFVFLLPWAGFWMLWFSVLAGFSFAVIEFAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUX6</accession>
    <name>A0AAD2PUX6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001823">
        <property type="protein sequence ID" value="CAJ1953191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="242" mass="27291" checksum="582C1F98A9518395" modified="2024-05-29" version="1">MEAMLPKKTVYTCFVAVDTRSLNIVRGEMNDRLNLPKKAEEILGKKANLNKMTKAERAKWANKARARRSKGQKEEISEKEIDFEPTLLVIIEEPKKEEEEVDDVNEKKEFKPSLLVVIEDPEGEDLNTMDESSFDAGLINDDFDSLEQDGSDGEIFASPTEQSDKAATNDIPSDGMGSGWTESGKRYSRRLQLKLSPDKKDPSTEALGSGMTEKGRRYSRRVVNRKVPNKAHSCYGLERDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVW6</accession>
    <name>A0AAD2PVW6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVW6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1957891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="213" mass="23723" checksum="D41DFA811E82C42A" modified="2024-05-29" version="1">MDLQVYPWCKNPRWEKHLERYNEELSRLNGFGCGKSSAFKLVINDCTQKWMEMGGVFLDRHKNKINYFKALSFVKKALRASKDRNRAKTSALKVPGPIACAGTNPAGPSVGTEDDNNHGNTVGNDLCASFDENSSTIEKPAMMTSPKLARPKLARPKRKSVLPNGFSYQAAVARSTKKPHALKQEQPKKSLEFFALVCSQQKPFTDENKGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX03</accession>
    <name>A0AAD2PX03_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS20457</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>urea(in) = urea(out)</text>
            <dbReference type="Rhea" id="RHEA:32799"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urea transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX03"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004937">
        <property type="entry name" value="Urea_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464">
        <property type="entry name" value="UREA TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464:SF4">
        <property type="entry name" value="UREA TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03253">
        <property type="entry name" value="UT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="638"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1964070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="718" mass="78557" checksum="B369A24AA9F48C77" modified="2024-05-29" version="1">MPKAQQVNAWASYDNTAKAARRLQSDGQAPLRQRKITRHSTSAVQNDQQALKDLEGGYRRASVAENADLAAGNVSRHRTSRVFLDLMKLQKLDDGEEVEQVDRNKEKEEESGTKKLFDLDCEDILKIREAVPIFFDTELHEKGGPAQSSIQTFLASLNATMPWVQDRLHAEPLIFFEMCLRGIGQVYFQNSPLSGLLVLIALFLQSPTVAVHGILGLVCGNLVALGLGFDKGLARSGLFGYNSLLVGLAVATFDVNTEYHAAKILMVILFASFSSVVFVMFGKLLVPYKSPPLTFPFIIATLMFLLSTANMDRVEFGSVRSPSLPNYSNSEALSAISWNDFFAGTLRGVGQVYLANNIASGALILAAIAVCSRISAVAAILGSALGAAIALATGVPAPQVAQGMYGFNASLSVTAMLMFYNPSIGASILAVFSGIMSVVAQQALASVLQPLGLPFMTLPFCVVSLSFIIIQGTTSLVLAVPLADMTVPEDHLHRIYRLEDGINFLKEAVLNDENRRMNSRKLRKSFKMIQSAVYEKEAKLGDVQPKSSSSLEGLFSNHTEEVVKARAHALFRLLAQKTGQDRLTIQTILDCFRDAGMEEGEPIMLASLMLNLADHTGDKTIDEIEFVCFAMVASAAKLIRTKLFKFFDFVDADCSGSIDFHELDVALEYLGRSPFTHDEKQRLIKLSKTMTNEDDDIETVELMDIVTIEKVKSLLGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX37</accession>
    <name>A0AAD2PX37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="249" mass="27850" checksum="85504D573BD15B78" modified="2024-05-29" version="1">MVVSLLSDGLYTNRSGEVDFQTPPIRRHRHTLPTFSSSPLLNHTTKMALAPCEKQHETDHLPQAAKFGKMTPRDRTMLALGIIFARLGIDASASAEEGKHPDNIGVVQNGRALVETTTKDPESTLADNPYSTDHKTIIDATLYNAVKTNGRWEYIKFASGKVLIKTNYPSKNLAKLTFTQYGSAKPNLKFCIKQDTENGYIYSKKMKRFTFNCVNNVNTTGEVESFSIIPKSDENIAKFGRYFDSKFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXX2</accession>
    <name>A0AAD2PXX2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS23359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002402">
        <property type="protein sequence ID" value="CAJ1968700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXX2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028307">
        <property type="entry name" value="Lin-54_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446:SF34">
        <property type="entry name" value="PROTEIN LIN-54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446">
        <property type="entry name" value="TESMIN/TSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRC" evidence="5">
        <location>
            <begin position="658"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="797"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="885"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="849"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1968700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="999" mass="107418" checksum="15344752E0137F0E" modified="2024-05-29" version="1">MTSRIPPTEATNEVSTSAAGSSSSSSVHAQHDDKPAEESTAAAASASNAESSSNKSSASHRSGQGHPQHDPPSASYSEPYSKSPSAHSTSSPHPSRNNQNNPNQSNMDPQLYDQLDLSEDIDESLLFGQFAAGSSSHEEASPRSPKAPPSEDRRRRSPPQSSTSHLPTHPASTPQSYYHPPTPSYSNHHSQHAQYPHYPTYAREGGSNSSSSISSHYRRASPPTGTPGGGSKHSSAAAAAAGAGARYPPSGYPITSPKGRSGGGGGGYYPGYPPPSYYSYHPEQWEGYYAQPPPGPFPEEDGIPVPPSSKKTRREHDLDVSRTPEKLPARSPFQSPDVSSKKGFFRRSPPPFQPSPGPFFGPSGSFGMLDTPSQTLPPSDFSPLGAQYTSNGEFNLEDSTLLPYNASNPTFLDLQDTPPANRRKPEGSPLTDFMSSTFDMKLHNTIMSSKSPLVLQSAEKAAAVTRSNSNKRHHMDASGKPEPRKLWPKEDGPPAGDASGGSRSSSKSAGAVRLEIGGAGSLSTRNKLDGINNMVQSTPSRRPQGYDMHPPPPPPGYHPSMHYVYREDMATPIKGGHYRPGPPRMYPSMPPSITKKNPYSPHPGSGSKPDYHSMGGSAKGPPPYLRPSPPNSSRKSPPLSTGKENVANSGKKGGPPGKRSPCNCKRSKCLKLYCECFAAERFCDGCNCNDCGNTPGAGLARDKAIKETRAKNANAFKKKFEKNTQSVGHNMGCRCKKSACLKKYCECFQAGALCGSKCKCVECMNYAGSQALIDKRRKIKDQRGADFAMRVADEAWKGKPPGLPLSARKGNPYPNPGRRYPTPSPMGAGRMPHHMMHPGGPPRGPPSHQHQHHHHHHPHYMGPPMMMGYPPMGMPMTPVGYHPHSEAHGMYPPPPGPPPPSSRKTPGQKSVATPASAEPKSPPVRIKFDPATSRKKRNTKAGEPEPTLPYFGSTMPAQPKTTALAIFSFLSNDEIYNAGLVCKSWSRLAVDEELWKIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXY8</accession>
    <name>A0AAD2PXY8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXY8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042213823" evidence="2">
        <location>
            <begin position="23"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="576" mass="63295" checksum="4DAA8A8ADD05437A" modified="2024-05-29" version="1">MKSPPFLSLLLLLTAAFPASLGFSTEDKERPKILGYQPLSPLVLSNLDLDHFEMGRHLKDGTEESFVKAKRIYEEGAHTKPFAILTLLAPLEIELKNGDLVAGETPNQDTVTGTVIGDHKIGSLQLAVIYNASTRDCSVGASWNPQTQGCFKSSGSVFLKDRDGIAFPYNYNPEEDNQNRMSLQKLSTHAKQQMYVCNDGDCPFRLYARYVDYYGNFTYADHWIQAAFNGGRTDLADSNGNFEHYGFEARADIVSKAAILLNLWMSIQFQLDHAIVSCQSTCQVKDHCNDESVHSWDLAVGWYAGSLAGPDTIGSDDSRFLHRLAEKRCVSFNTCDGQHGVSHVNKEMFDLFDAGQELLTLSKCSDANEIKDRISRLMLIPLIQDALWHAHINDVKPEALLKEKHAAQKISAGAATVAAAILPQIDSCDPQAAYAVYDNLRTGHDASFETVKNALESTYECLGIKCEDVGGLYITKQDKYVEGAEPCYGSGGQPQQASTGDASATIEQHSHGLDKLDVTLIVICTILGAIILCGTSYWAYVKNRCIMNHLPPLEAYEATEDAKDPPSLKVDDAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXZ6</accession>
    <name>A0AAD2PXZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS23582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="51"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1969192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="322" mass="35620" checksum="2A142247AEF99D43" modified="2024-05-29" version="1">MKQRDNAARAHNIWKDGEDIVDYNYFRKEMAYRLVDRLDDIRRQEGFPLALDIGAGSGYIHQAICADDAFEGEGGIGGIRKLVQLDFSEELLNRDIDEGIEGVHRCDTYRLAADEEGKLPFPDGTFDLVLSSQAIHWVNDLPGLFKEVQRVLKPDGCFMFTMVGGATLPELRISMVLSEMEREGGVGAHVGPFVELSDVGSLLQSAGFSLPTIDIDTVRISYPDAFVLMEHLQRMGENNASLRRREFTGKDVFLASASIYDEMFKLQEIEGDEEESDVEASVQVISAIGWSPHASQQQPSQRGSAQHRVGDMITKTTGGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBC4</accession>
    <name>A0AAD2CBC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1904029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF11">
        <property type="entry name" value="OS06G0360300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1904029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="243" mass="27103" checksum="CA3AC05C17CA8D5F" modified="2024-05-29" version="1">MTIKVLVVGATGATGKHVVQMMLDAGHEVVAIARSKESMLQKLKDDKASHDKLEIREASIMEMKQEELVEVTKDCNFVVSCLGHNMSFKGMYLQDRKLVTEAAKRLTKAMPSSCKFILMGSDGVAHHGVDPPRSNLEGFIIFMLRYLVPPHADNEGVAAYLLGDTSFDWVTVRPTNLVNEEEATGKYNVTEKVEVSLFGDQTVSRNNVAHFMVELMTKKETFSKYLHKMPVVVDIPEDKPSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCF9</accession>
    <name>A0AAD2CCF9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000069">
        <property type="protein sequence ID" value="CAJ1929117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="134" mass="14940" checksum="0D2E137CA3205A51" modified="2024-05-29" version="1">MAAQAMPSDDQVQTRMEKEARTLRAGAIIEYYDPIGVCGDSQWFRRSVIIGVEQEHRTCIILNSGPALGGFDRVKRIGSIMPDGQVIASEGGVYMDVKDYHLVESHFEGTGKQGRNFLAEVKAEVDCFWNNNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDH4</accession>
    <name>A0AAD2CDH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000080">
        <property type="protein sequence ID" value="CAJ1929418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044999">
        <property type="entry name" value="CbbY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896:SF2">
        <property type="entry name" value="CBBY-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896">
        <property type="entry name" value="XYLULOSE-1,5-BISPHOSPHATE (XUBP) PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041975846" evidence="1">
        <location>
            <begin position="30"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="298" mass="32470" checksum="A88A42AAB02B14BB" modified="2024-05-29" version="1">MFVPKSAIFSALPLVLLLVLATSMGSSFAFQQPTQSTTTAPQISSRIQQQQTRTSTALHAKLEGILWDQDGVLADTERDAHRPAFNAVFAQDNLDTEWDVERYGKLLETGGGKERMTAHWNEVGWPENFPEDRQSKVKELHLRKTDIFNEMIKEGNVPLRPGVLRVIDDAIAAGLKLAVCSTSSEFAVRNLVSTLMGPERASKFQIFAGDMVKAKKPAPDVYNMAVETMGLDKSKCVIVEDSHIGLGAAMGAGISCIVTKSSYTVDEDFTGADMIVDELGDDASTGVTLETLESLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEC3</accession>
    <name>A0AAD2CEC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS2175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1930967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF166">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042039499" description="Cyclic nucleotide-binding domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="128"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1930967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="601" mass="66865" checksum="DC7A9661801EF518" modified="2024-05-29" version="1">MKKCKSLLAFYALFYHAKALSFASPLTHGRTRSLLMVNGGTQQLWSETEEAALSEKLESDPSEESMMRGGEYSPSAWNNETDGSNMPMEGDAGSGSSPSTITSRTFDSDAEFLESVIKASNFGQGLDEGEDLQDIIQAFVKTNYSKGELLFSEKDETGDFLFVVESGQFIVSVEGQQLPAPYGIASQGSIIGELALIYDTGRVGTVRAKTDVTGFRLDRDAFLKWLEKWPGKRNDLKHELKQIDDVIAKVSGVRLKYGGSVIRKINPSRLWLWTRWSGTILQHAWKVSLANLLTATTLVVATRLLAKPTWGLTVMPDPNNPLISKMLGLFDVWQYLMTVTTFILTFFLGQAYSLWRDIYSTARVVQGRLSDINLMLAVSAERDRSGAYTKRARELMEDVASYTRLYHVFMWASFSNKLNLLLSDMGLRRMVNRGVLSRKQFNTLQKLDATTVAPQHACLIWIMTRFLKGMQDNVVPNDVTMKQTLFNKAMELQGTFAGVGGKLAGRSPLAYVHLVQILVDSFLLLAPVALTYKLGVWGIPAVGILTLFYSGLLDLSKILLHPLGNDDDIYDESVNMDLAVIIRESNGGSTRWMDGGELLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFP1</accession>
    <name>A0AAD2CFP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nitrogen permease regulator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="67705" checksum="78768FA4A95C48BD" modified="2024-05-29" version="1">MKNLETFLRTTGTLSLEPLSPERCPLFAVFYSEFDIKVGPRICFQTPKKFMENEISISTKKIEEILGATFDTLRDDDDNTANGIDDIENSEGTESAFSIFDSTSEYIITGSELTGKIITLSTHELHIMTRPTLIADERYERNSLLFSVGIVLRRAADPRPFRPVISKLAMALQSMEVESQFLSHSSSRPQLQPLLERILLSMNGSMMECNALLGSCNALHLKLFHPPKAEALPIHDHEVPILLQKKLDLEMHEWDLSISWTLLYIDGVRTTHQIATKAEVDLEMVRACLRVLKHHGFIAMVDIFVYSNRYEFTPKATAMLAGREESLQQEAAHYSRKGNLSGTANGRPGHTSDSEGESSRHSLRSSRTLNVLNTRPSSFKPPSKMLADYYETQPNRTTRHKELEVALAELYCTCNRNVSFGDLWVALTMNKTTAKSTHSPVREKKDPIDEEMLDRNSVDSFAISPSEAAHWQSIPKPTSGGSLDWNYFLTCIDHRRFFSFGVVHGLVTRVHEYPYFHGSFPERRQKQLEMNGDSKRSVQQASLEEKSYNLARQIATLMDGTRMDDEFVCSFEQPYRWLVKLVEDQSGEKVASILMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI81</accession>
    <name>A0AAD2CI81_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS4328</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tweety family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000435">
        <property type="protein sequence ID" value="CAJ1934991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF19">
        <property type="entry name" value="INTEGRASE ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0868">Chloride</keyword>
    <keyword evidence="9" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="137"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="645"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="854"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="904"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="971"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1256"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1397"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="783"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="865"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="980"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1017"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1278"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1934991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1567" mass="174689" checksum="36E0AE58B3AE196E" modified="2024-05-29" version="1">MNSSLISTTPVSQPQCPSRLIFWQDDPSFTASPFVPSNMVKWFHERWYRFGRSNDLVNFIINNDDNDSDDGQYRTGLFATTIITGTIIFIWMSLILVYSQRRRHKLPGQKKQQDIYRKIKQKEVLLQYEQDEEENKYFGRPFSKPLPPREPEKPEELVDNNTDPSTEIASSLSPEEQKLRETRIRDYNRDLRRYQSDLVGWNYARAVYKRRINCTRITVVVGCLVVIIGSTLFYIQGAKHLSKAVQDSKVTLTQVQTDTQQEMDRIQGFLDFSQSSNITQILDHTNSYCPLVKPRICRNLLLDEDCDWSGIPHGSLVKSWISTLIQYQTKMSNTMHNLHHDLHSSQVEIDDWVSTLENMELGLTLSTIFVFLLDALCLYILLGVALAWSKRRKVPNCFIWIRSYCLIPLFALVVVVCWIFASTFVLASLTTSDFCHDGPTEKVVALVQRGDGSISPTLRDLIRHFVTSCSNVFVPDIFSSDINQLVQSVRDTKMLQSNIIIFANGDIKDTCGPFSESILSGVASMAEGELCQAASILHETRIHAACSTWNPIFTSLAQDMLCNDAMDAFAWITFSQLVIVFVSMVILTFRVAILPVKYVRWQPRARALSRQVTADLKKISALAQAVSQETLKNTKIEPVYHLGYASSSSSGTSESISDYAEVSTTEPSYYSDSNSLQNPSGTLPLLRPPEIPPKMVDYEEDSSESPKKTESNKTLVSSNQQQAAPIMTQVVLEMEEYESDDVDDEKKPESESLHSETIQPASQQSLISTTASSTPLEKPESYSIHSESVPVSQRSMTSRGGSIDSSVEDVVKPESAIRVLMAKGASVRQKIQSDDSSFEEITFLEDSDFEEATCYSMSSHKRTSDSSMEGSRRSNSNSERKSLVSGHSRRSERYLLSLDDVAEESPLANSLSPKPSTKVPRFAPGNAFMDRLSIDNTTPSNKAAKRPPKQMSLPLEVELGRLNARADTASSLCGSMTDGSKSLSAESESNALEASSTNEQAKLLAESDAGIEPPQNPERKDDTRRSSRSLRNLEEVRNGELTKGGDESFHFSLNLDMETYHSTDFGDFSASEGTNQDTFAAAEYEIIEEVIPPDQISQRNLRRSTSISALSVDLDDPAYTSFTSEELVKDSDAKVSSHSRRTVNGDDKGVDAQLQFQKELLWDTSGMQTKLEDESWNNNDDTTAHATASKHIDISALQQRVDSIRSLGSSSAGLPRAIDSEMLAVVDEAWTEDLRDEKAPSCVPPKAQMRNLVKNLRSKQRSWRADSVRSHGSGQSDQQRKKPWRADSVRSFGSGRPDQLSRLSGGDASMLSLNSDDLMWPSGSTNLSGEFEFRKPKSNRSLVSSPSIAISAATMNEKQFYLDDMGESSDSFGYAVLPSRAIDSEMLAVVDESWRDDVQDQEMPSSQQAKAHMRNLAKKVQPQPQQRNRTQPKDIFLQKRPDSIRSLGMDSFSGSMSGGLSTSLSDDFDNSFDKPKKPMSGLSLVSNSPSIAISAATLNEKQYRLDDMGGSSDSFGQAMLPSRAMDSEMLAVVDETWAEDAQESPSPAKKQLEMLYKLDEKTAPMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIY2</accession>
    <name>A0AAD2CIY2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000228">
        <property type="protein sequence ID" value="CAJ1932985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIY2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1932985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32213" checksum="38E440847B70E79C" modified="2024-05-29" version="1">MLYESRIIFLLASTTKQLPSADILTILAAQGNTKTMNNNKSNESILLAQNESGEQMIEFALLFLTVPDLRNVATINRHFSKHVPNRQDVWKVILEWFERANPLMSVDNPPSCEDMRSARQGPSFWPAMRGSMLPPSFRPTSIPPYIRPTSIPRQEQSFWPRMVDWLIPQSFRSISRVTLGHPQAFPLRNDPRLSPSFSHESNFEKLMAIQAYAKAFEDMCDSNSMMTIQNSNTSPGELDEDGVGMVLSCVTHSQQGRVEDPSVTIYSGTSRKSRRKWALSAKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJP0</accession>
    <name>A0AAD2CJP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000554">
        <property type="protein sequence ID" value="CAJ1936139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042247063" description="WW domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1936139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="768" mass="84891" checksum="CC34A1C8A6DF833A" modified="2024-05-29" version="1">MKISSTVGSLLLVAGLAATATEAGSSGGQGTTYGAGRTNFDGNTQGLYIDPTKESFGQESWSMQNSIVEEQNPLPSGWSEHFDQSSGQYYYYNSLDGTTTWYRPAPANMETSLDSTLPKSFERAETEVSDLTGISEKHVYSPQERQKVEDSPFSHQQSRDDSTETVISKGQFNEENSAPGFPANREYQRGDSLSSSVQTNDDADGQRWNQLDIASEQVENRDSLQLLNGPEDNTAGAIAERNVPRNPGIAPNTSCRNNDSAENRENVGRQRNTSPNRDRAVGQRPSEQPQVGGWGLQTEKAEEVGRGTSHHSPAFIKRENNPGTIPQYSQVGRASGLPSESRQVSSLGNIRSPGDVPIHDRGNPVYQSHIQPQDRSSQASFAELEQRQQIVGGNRSPSSNGQSATQHHQSSSGNGDLRFNAPPRSHLPNPTYGSRAESPRAPLRRPQYPNSQYSQQQSSGEPPHGKYQYSQYQQPQGDPKSSQYRGYNAQKQAYNQQPSVSDAVTGVLEDGTTAMKDVLGKSWEGLVGFSSRTRDAMGQARDQVVTGASVAGQSISEKSTNWWGQAKSALGSVFEKSDDTAEPQYSMSNPSQYGRQPPQRYPDRQNNQSYQGQDPTAYGPQGGRAQMPNNHQYERQPPSNQRNFQGQQKQPQNGHINARPQPRYDPPLPQQGQASPPPHPYQNQYQYRPRRPSYTDQQGHQADRGPQQLSQEQHPDPWTHPGGEGGGQKEEEEKKKGFQEFFCSTVLQIRTFALKLDHRVSVIHSNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKR0</accession>
    <name>A0AAD2CKR0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000507">
        <property type="protein sequence ID" value="CAJ1935768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="17132" checksum="5B5CADE42617FD79" modified="2024-05-29" version="1">MKADYEEHNAILIACCMMQIKAKFDTDEGLNFIQQYYINQGLKKFGDDAKDAVDKELRQMLLRDCFTPEFVKDMTASERKKAQSAMMVLAEKQFEKTSKGRLVYQGDETREWLSHQNGYSERTLQVKPLCRKQSPLLVLLMHTKVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL00</accession>
    <name>A0AAD2CL00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000421">
        <property type="protein sequence ID" value="CAJ1934933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="423" mass="47168" checksum="47189E4A4B89CA4D" modified="2024-05-29" version="1">MASLCENVLPDILEMKEDYYEDPRKTLGQRVQSLETQVNSRSAGTNLLSSLSSTGSVDRRGLAIGGSVNQLDAVVARLERLEMANASLREEVARLTADAAPQPELSPAPSTAMLQQLKERVSHLEQKDNEKVNVAGFAFGGVADCRHFLNTKMVFDSESSGLFGTDVVSIVDGVTTEGGELLPTDVLRRDEYATKAGFDNIMAAKLYSSIQRPIPIPLAGKGNHPLPAISTFAKWDEQDGMRGLRYEITRGVDHEVNQTTEWIRAQLKPHPEAVLVFTTLVLDSKQHWMAISTFLTNQRGICMQQSDDEAEAWVYPCEVIKGVFMELHRVRSVDAMRSKLGQLTLDDAARMMWAVLRCHQLMNSFIDLKFTGHPKLSGYSLSHLFRHRLTPKNLDSMKAQLSQFQREMTTFNAKLAKKKDRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMQ7</accession>
    <name>A0AAD2CMQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000076">
        <property type="protein sequence ID" value="CAJ1929296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36170" checksum="8D88149B76DB79F3" modified="2024-05-29" version="1">MDPKVNDKFAKRLNMRYGLIKACTIVRGKIHRYLGMTLDFSVKRKLKIRMDDYVKNMLEDFPIKFNKDSKQETPAGNDLLEAGKGKLLNAAYRQIFHATVARGLYVSKRAGLDIHPTITILALRVREPTESDWKKCVRMMRYLFCTLLYHLTLSAESLRVMKWMIDASFAVHPDFKSHTDGTLSFGGGAAQVMSKKQKLNSRSSTEAELIAVDNVVTMILWTKLFMGWQGFLIEKNILYQDNKSAILLEENGRKSAGKRSRAIIIRYFFITDQVEKGNVKTKYCPTDNMIVDFMTKPLQGEKFCKFRDLILGPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN29</accession>
    <name>A0AAD2CN29_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000713">
        <property type="protein sequence ID" value="CAJ1938389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="96" mass="11221" checksum="E48B4342BF68ECD1" modified="2024-05-29" version="1">MNTNNATFCPFPFASLKPFENYSHDRVDICWNLPKSKIYWSCNVLILLPLYQFFLHDCQALFNMTHSLMSEQISNQKPTNGFSRRRRGSDLSPSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN59</accession>
    <name>A0AAD2CN59_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN59"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="481" mass="52452" checksum="14FAE91C9A39BE67" modified="2024-05-29" version="1">MKTNSTCYFDPSRTQSRLLFLPRFVCSIFLLCYLLVNPSTAFQHQHPVIRSYPKTTRLNEIGTQSRPNIAEYSRTSKVRLPWRPRDYEPARAGVAAVLILAIIIGLSINDSNDVTQDEIAVTAVSNVVGATLPSSPTDLVAGALGESVGGFVGVFASASLSSLLNAFKSKNNTDISKDSRMTNAIAESDYFIVNSASLPLLMAIGLPPVLASVGSTLFAVIPSELIKLRQRRREMVIEEDRLLNDLLAKERNRRNSRPTMPKPFAKAKESIEEKVSVDNLLPVEAGGDVDAVEIFADVIRWLEYAVLKAEFGGTLTFNNMVLGPGISGAIFGIIASVSSQFYADVLYGELFELGPRSKQEEVSSRLTSDWVKVYASSAVSSAALFGVFEEAQIPVSRWIQGILAGGVDGCIGSTSFDICLQTYIDSNAPGPSPEAQLRALLVNFMMVGQRVQDIAGDTTWDDLRRLLAAWSVSAYSYFQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQI8</accession>
    <name>A0AAD2CQI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213:SF3">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="87409" checksum="F0449EEF4FE7EB2B" modified="2024-05-29" version="1">MVNFPNSGVSSAFMSPGGGIIQQHQHQHQHSEIHCKQCGMPGCDLQVLDCGCFLHARCTPISPHQQLTICPPCGSRVRSLMLIPMNFNEIDEAQAQAAATSPSSKRGKKRKNATIARLNPSNSRVDEPGDGSELRTGRWTSEETMYCDKMIEKFEAGHLPIADGVKLNDFLAGMLKSKQSRLTKKMKNARLSAKTYKRSIGYIGNIEEAKEVSQLERLFFESIHCNMERAEIRFHMQKEWRELFSSFCVSMGQKLDADAWLSSVEEMDKRVSQAKDAARMARRKLLMGYALSQDASNREHGVFIENNVANDRNNEMLPSHASSNNLNGMLPKEKKPRPDHCATSLRDFSSPFVGRVVQYLHRHKLPFEYVDAWVPSFVPSSDSPDAEQKCRLCFAGFASCDVEIPEDGGTPVPISSQHHFDLLSFGEYSAKFSFDVGCGLPGRVYQSSVCSWEQGVANAPSQQFERCGGAHQWGIKTVLGIPISSPNVGRIVVVLYSRHDRLRDPEMARRITEEFTKLKPTPKWKLVVDLGEVADAPKTANLADMRVSELLNLLEQFAPSDDSPYAMYMTGFSMLRLLLVKQVKTPQESEFISTMLESYSSYKSSGRRNQEIACLVARDFMVVYQSSGGVGVPDQQQQQQQQQMKSNSQQIMNVQSMQQQFSAQPLQSQAMQQQQHQQQQHQQQQQHANDLLQLNTMAPVTSTNLGLNQSALGGSQNSFMQGGGPTQFQLNRLVQSQALLASGQNMQQNNSLQLQNLHHPGIEQMNPIMMGTAFHPPHQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQK3</accession>
    <name>A0AAD2CQK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1942776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="194" mass="22211" checksum="08B9FAAB767FF7C2" modified="2024-05-29" version="1">MVLRLTISRNRHAFQVAQKHFSMMATRRKPSLRRGCALRLQSSSPQPPEKRNWPLLISVLTIPTMFLAWGASDSIFGNRQIGENNKLREEFLANPMERQRDEDLPVICFCVVRRVSKGNHCLVGVQLADVVEVLAEGVGPQRQYNLCRLPANPDEPLSTDVYGWFPTRNLQKLDDYHRMVQAQKKLLGEDKEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRR6</accession>
    <name>A0AAD2CRR6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="176" mass="20256" checksum="34DA51F532D934D5" modified="2024-05-29" version="1">MIPLHILALAQKPVIELLGQLLLLLLSGFDVARTTKDFFGSTVLEYLSKNPLEEGRHATRWLANLLVGQQLPFLRLDRWKHELLAEEERVVRASDLGISSNEVQSFLDKLVQLEFLEMLLELKLWKIKLDENPMEENREKVKENAFRHSCRVSCGISIVVEHVIPFLGNNHQVTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRW4</accession>
    <name>A0AAD2CRW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS8032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRW4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042001338" description="Fatty acid hydroxylase domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="148"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1942608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="297" mass="34028" checksum="AC5BA39C44708148" modified="2024-05-29" version="1">MILPWMSAIVWPCMLAVPLAMTTPGSPLHYSEIFQKRWYEYDPSTDDVMPKPLGLSLGLLAVAVGQVLILCVFGGFKFGYFTMGQEPLSIQTKGARPYVFSEGVMTHLAQPEGFVLLFLYLAGTWMGKLMPDSYYSFEGGIEWVKVFGCLVAQDGIQYAMHRLEHDASPAFYKYSHKPHHKFTNPRLFDAFNGSILDTICMILIPLYATANIVHCNVWTYMAFGSMYANWLTLIHSEYTFPWDNLFHIFGFGTPADHHVHHAFFKYNYGHLFMWFDQLGNTYKHPSHFAPKAFNRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSS3</accession>
    <name>A0AAD2CSS3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSS3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="4">
        <location>
            <begin position="59"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1942412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="241" mass="27504" checksum="8366D2F468D17BF9" modified="2024-05-29" version="1">MMILKMRPLLTLFVSIFILLLSFFTLSNALFFPQSAFSNLHVKFDTVADIPKDYFQQQKTIFGEVARVIDGDTIRIAHCRSRFSCPKIDINQKKIFDKTMSIRIYGVDAPELQKRKSDPPSQPFAEESKQLASELVLGKKVTVKLLRRDQYGRAVAKVQTPRRFNSFPPFVKKDLSIELTKRGLATLYTGGGAEYDGNRALLESLEDKAKKSRRGVWSSDNYVSPAEFKKTQKLSKQQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT36</accession>
    <name>A0AAD2CT36_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000902">
        <property type="protein sequence ID" value="CAJ1940526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="175" mass="20545" checksum="CD5186E00A5B2D3D" modified="2024-05-29" version="1">MLQHANVFSAREEQGQLATQRHQERAYIEEQAHVPRRCGGYAISAKLVQRTAIHKAFEYFQDETWDFGYKSGKRIDSAALKRSLNEVRDITGYDVPWRQFRDWLTYYLQFGHLPSRKKAWKGEQGRSKRLSFTANDDEYLQSTIEEQSQLHLDEIVTEMTLWKQIGSECAILDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT60</accession>
    <name>A0AAD2CT60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS7848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="267"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1942240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="377" mass="42357" checksum="D7016A0E65F2528B" modified="2024-05-29" version="1">MHGNDEPPPSGDPSDIRRRAWSLEGYRYGNPGLAMSLLRNSSEIDVPETVFNETPAAENSVFPSSSGPNDALFVPGGLLSRGVTSHTEHSGASSSVGNFRAHQDEMAWEAAARTNDSPSMQHLESRLLLQSQMLRQQRLASLTQQSMQGSLDLRQIRFPNNLLLNMQNQLQMDQQHFDQQSLEQQQLQNYQPNQALISNFLPGGFLSQRPASLAMSHLRSYMNPSLLTQDPLASSPPNLAASHPIIPRSIQYTTAASQGTDLYAGGRDSTFPMKLHRILADPRFRDCICWLPNGKSWRVLNQHLFADVALPEYFKHQKYASFMRQVNGWGFKRARQGPEINSYSHELFLRDDPELCSTMRRLKQSSFKGTITQADDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTE3</accession>
    <name>A0AAD2CTE3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTE3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="556" mass="61798" checksum="9EB956CEDB0A2718" modified="2024-05-29" version="1">MDKSSLLTFAAASAAATGVALSLAQTDFVSRKFLDSKQLDAKRRSEYNYRWKAAMEKAYLQINYTLAGGISAVHNSPGLIDKQIEVISDETEMEGLAKRIAAKDSQFRCLKVDRDAQDTQGEFYLFLIDWETKYLYQLPLMAFGTVLAGVFEDQLTSNTLCFVADASSGKGTALLKELVLESKSGVAVVSEPLWMVQLARLVQANLYPAEKIQKLFFGLCRMEAWFVRDECKESKTVMFTLPGQACTSTLLPLAQKTFPEDRHVFVYDGCQASIEYANNCIRKKSRGKVASSLESVLYGASQDPIIHSVPLPSNSPLCKSVLKLVNKLSDLPVEQAQVVECWMGSIDAFFKLKEEEKKNGYLPYVFKLQYLTDGAGKYEDKSASYWTMCSILQFIAGSRSRQLSEGLIDAAREFMKDYNERIKGEGKGYVLSKNDVKIMEECVFLHKKILLGNKTLQDTVQPKQHWTLKEASKKGGCACCGPEDDDEEEEEQGRGRPVGSRIDMSMPGAFAMPGALGMPSGTKRKSNSPTGRKNSDSKRGYVDGRAGFAFDPSRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUB0</accession>
    <name>A0AAD2CUB0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS10195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011719">
        <property type="entry name" value="CHP02058"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09585">
        <property type="entry name" value="Lin0512_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="529"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="711"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="389"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1946054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="864" mass="91798" checksum="6BDEB9AE83A0BCAA" modified="2024-05-29" version="1">MDVDARTQETAAALLGVAMKRHQAPPPAASAAEAPHNINDSLQRWGTRDGTSASSAPSVSSPAPAVGVASVPQASAPTAGLMNGANPVAAPAVPRAPPSSHTAGAFVTPQPSHIHMPQHASAESAAASTSSVPLHTRQAQQVQTAPNGGADANTVLSMSSIGFGIDSSAHASWGNATEAASRALQDAMERSTLRLPMTMPAQHLLQIKVQLGVPPKQPNSTEPMNVDLSRLTSILPRAIPVLPIRVDVGGLFMRGETQGSPSICTAVACITLQSRAPLSMSEQPVARAFHSVPAQPAHPQNPWTNIEVHPSTATAPTTTDPAASKFVKAPSPAASSGSADIPHAPASISSAAPAISPPPQNPSGPATAALAQASPLSCMPSASPSVVMPLTGEPRVPNGILPPSETINAGGPPPPPPPPPRNVRRNTSIEMLAMISEEIRLAGDKNGSTTELTPNEDGIYIGLDGQPMVMGEDGQLRNGNYNYKKLPPGVTTKNNRRLFVKHSYRDHSSEKPLPEEKDLTGVGSSTRTPNAAFPLKLHETLTQIENDGHDDIIGWMPHGRSFKIHKQKEFAEIILPRYFVMTKKSSFLRQLNLYGFNRFSAGPDQGSYYHEKFLRGMKFLCRRMTRQKVNGNRIRSAGNPDEEPVLSSYPQCPDVGSTIKSPSGTMLAASPSAPNGTSYSPQRSDGMYVDNPSISQDFNGTGTSSSSFDSTVVSFPLQLQRMLDKLEADGNTGIISWLSHGRAFIIHDPDAFAAKIMPLYFHQSNFSYFQRQLQLYRFQQFTSGPDTGAYFHSNFQRGMPHLCARVARLPRGSMGGASGIPNAEPNLYAVDSLPAIERGSIVNAPSGKVDLMMDDGNVMQTEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWF7</accession>
    <name>A0AAD2CWF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS9598</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001435">
        <property type="protein sequence ID" value="CAJ1945455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWF7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="136"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1945455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="350" mass="39627" checksum="3C41DFA08C12BD8E" modified="2024-05-29" version="1">MQDAKNYYKNNDEITTPTSHREGESEPSEDDPKPPMRQTPMTFDLDMDKNENSVPVQIEDDEEDTQKQNHAAEFLKYHHKFNHCSPAKIQAMAKKGELPKYLATCDVPVCSACQFGKATRRPWRTKNKKNGRKAKTATRPGQVVSVDMMEAGIPGLIPQTSGFLTKERYRVATVYVDQYSNFSYVHFQKSTSVEDTLVGKEAFERLAATYGIQVQHCHADNGTFAAKGWIDACHRKKQSISFAGVNAHHQNGRAEARIKHIQDMAHTSLIHATKRWPEAINAHLWPFAVRMANLSINATPWLADLKKRSPEEMFSGSKVDNNPKHWHHFGCPVFVLDKNMQQGRRPAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D0L5</accession>
    <name>A0AAD2D0L5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS9774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D0L5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF21">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="850"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1133"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="866"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1138"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1156"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1945630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1166" mass="129811" checksum="28764166F520CE57" modified="2024-05-29" version="1">MLCAHERSPSVSSHGSLNSTPIVKEWRKRRSIPDLLAGRQTYGKRGRFGKQMGIPHDLLSYRTAWNRSRLQNMILAVGPGTPAALVMGHGPLHAQASVSTSSSSSSSAEAEPDLSGSEESLEEDTRERNEEGADGDGDDTGGENEAAGGSRARWTRQRRTQSDSDESGEDGTQQFVNAAFRRFYGEDSSSSEDEEEVQQNGICMEPKYAPSMRHGGCINTATWMDCGWRISTAGSCNEPVKTMDCPTQLVTSGDDHLVKFWDVREAMGSTTPLAGGVTTMCPFAQSHYCPGNNATDEWSRYFNATGRISGAVLPLATIRTGHYNNVFHVTPMATPGKVATCGADGYLRVADLQSAESSVIVSPEFDEELSDMLPAGFLSIRSPMCFSHHFLSDHTGLLCSERGLRRFDIRVPPRAQPSRSLLGRRYRVCKAFAVLSSPVTTSSLEEGDSVYVFAGGSSSDITLFDLRMTDASAANRVVQVYRPSSLTPLQDVSVSGIDLSRDRKELLVSYESDQIYTFPVFPRNGKGLGPTIDELRDMPVERSSGQNAPLRELASYGAHLNRFTFLKNARYAGPRDEYICTGSDSGHAWIYEKATGSVVSFLNADNSTCNGIVPHPSLPLFITYGIDSTAKLWRATTPIDSEIDDSPSGRLDVYHKSHYEMSPIVRKWNEIQPLLKVLFEEPGFESKDILPDSIPGAKERKEADMYGSRGGFRRHGGQPRICNDMQNLTKVVKLNLYSCIKSRVDGEDDVPVESDLDALQHRVCMIRQRHQADTMGLPWNPNIPWRLDSAEGLDVHPADLIPQSPSDWILHDSDMHRSQMGQHEYFNAKQYEDFYCLRYSNLEDIEPFSRGPLVQPGSIHVGDVNLSRKDEQNDDKTTGDKPKKRKEHKAKITDAARASGSEDAEIASIDDGNESEQTDSTAPTCKMNQSSFENNKDDLAHNQLYQTMLLLKDAGNEALEARNFDTAARRYDTGIQYGAVACMCYPTLKVIFSDEAGKEMRANGWLHLEWTPTVRLLIVLRLNHALVMLKPYFAQPHHAVEQSRLALLELRPFCTKKGKIMKGPKMTEVYREDEPEDTFLDAIKLQAKAFFRMGCAHYEMGEYREAIRAFENSVKSTQLSGADTDKGVLRRLTNAKREYKRTRKQQKRFKLSFAPGDEESEDDSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCI6</accession>
    <name>A0AAD2FCI6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS1023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1923318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="332" mass="36974" checksum="79708A86C7D3B20B" modified="2024-05-29" version="1">MHELWEAVQKNNLALVNKLLDDGEYDLKIPFEETGYTMLQTACVHNLVEMTRLLLDRGANVNEKNEEDGTPLLLAGSTGCLDIARLLLERGANVDDYDEDGTTALQHACYSERLEVVRLLLDHNANLEIADSEELTPLHLSCTNGNVEITRRLLDRGANIEARTAQNLTALHLAFQKGQLRIAQLLLDRHADVDAKQMNGLTQLHVACRDSRIHVVKMLLDRDADVEVRDDEECTPLHHACRSGLSPTIVDLLLNQGANPNAQQATKRTPLHDVCMSGFSEAGQILLDRGADVNVVTNEGMTPLHVACQHDRPELVWLLLHRHPLLIFGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCM5</accession>
    <name>A0AAD2FCM5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2454</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000159">
        <property type="protein sequence ID" value="CAJ1931582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000159">
        <property type="protein sequence ID" value="CAJ1931584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="242" mass="27463" checksum="85256A6885232BB4" modified="2024-05-29" version="1">MWRTASEFFANPWTVPAINPHIVEEFERLKGEPTIAKAQSKFKKRLASTPANLKGAKAHDSPENLNPSNEPMEFVEIVWHALTTAFPTKQGWNQNEELLSYLHTTTILFYDFYAAHQKWPPTMGSNDNNSQEMALKSTRTAPEHAQEGLEATTRSNSTTLLTVDLVKDNPCEHKLSMLYGKFVLFLSLEKIQQTDFLGLPFQIPTNRVGAPICPLTDDLRELHPILSLEKVFSFEHIHTCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCZ3</accession>
    <name>A0AAD2FCZ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCZ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="561" mass="62383" checksum="36AE320793BD3ECD" modified="2024-05-29" version="1">MADNCEVLDILAEQDPVRIPFENTPTIEYYHNTLPRLSTNKDLLDDDYNQAWAGFITAFIGFFLIWGSMLGFFKWRGPEKAGWISGSRTTKQTQVEEPSSNDNGVFSSFRILAKKESTAVENKKALPKKQSMFLRILLYITIFGIITANGILYFTGLKNLSSATDEGLATLDQAEAQMKLSVCLFEQVIDRMELAENNTQELLKRANNICPRVQNQFCQVLSDPDSCGSDSNRRLLVDDLLGWAGYAYDLASEQAQTIVNFLQSMLQSMQNGIQFFQKEVNLKVQLQLMRDDLNGKIEANLVDTKDQVETAALMVTLSSVLCLISTLVCIGLLAAHFLKKPRLLKVFFGFFIFTTVLIIVAAIAITIAAFVVSDLCIDDPDTRAIELLLLRLDLKSEILENVARGFFESMADGDICFEEPPTEFLTNSIDFVQEGMDAFDGWSGFFNGFDSIQELACGADATSFADVEAFMETSINAKLNITAVFLESAGQILTCSFWLKLFEKGLHQATCYDGMEALATVAPAQFIIACLCMLVVTFRVVLWDTIILEADAGGTENHQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDG8</accession>
    <name>A0AAD2FDG8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="222" mass="24899" checksum="1A85BD68E74FB7F2" modified="2024-05-29" version="1">MKENKNMDANDGDDDDSPNFEALETSLDSLTGELYQVQLHHNSMKHALAEAREANKELKKDKSALEVELEDISDSLEEESACLGQLKAENKRLRDEAAKCANDADAVARETATNKKLNQENAALKIALETTKKEHDQEVSKQAQNLEDKRVAIHKFQQEIATLRSELEQLGKLHCRTTESFSVQTKLLQEQCKTLVSPEATSHEQKSPMGVDDGRKARRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEQ3</accession>
    <name>A0AAD2FEQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3263</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6905</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000262">
        <property type="protein sequence ID" value="CAJ1933337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="286" mass="32565" checksum="B5A860A664E4D3D0" modified="2024-05-29" version="1">MSNASESSSDEFENEWEGSNGSEEEESSTEEKTIAIVEKVSARLNGLKEASASVKLRDKTKENLHMLHKYLDSRSKIDDRIHQVDEFQRIATFPLVTDSGGIETKSDDPLEFKSDFQQQLAEGKPVITLDERHIVARIAKPIYRQTLENIVDQVYSFCGCNKDDIQILGVPLKGSERAQEKADDDYSKRKPGPGVSWLYDIVRASIIFSTTEQIARCLEAIRDDPSIRVVKAKNRFEKPTLTGYRDFNLCIQIDIPGYRFRHICELQIHHKAIQVLQTELKTTTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEV9</accession>
    <name>A0AAD2FEV9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000293">
        <property type="protein sequence ID" value="CAJ1933710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEV9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="610" mass="68824" checksum="44F6E7909EE22C74" modified="2024-05-29" version="1">MKDKILQEVDYNEKIEGDPIELLRCINKFMTTSDVTDWEPITLWEALQKWVNCRQKGNETVTEYRKRFEECTTTVLSFMGDSWLEVFAAKTTAYHEIENNHPTNGLSDREKKRVAAQVEELQHEFQDEFVKLFCAAGLLHNCDRARYQPVLDHFVTAYAVEHVDYAQQDLFPRDVETAAKALHNHRVKKPTTTKHNNNNNTNDKSNTPQSGTNLAQDYNKGSKRKCFCCGKADHVAPRCEHRFLPKEQWKDPTKWRLYPRTEAGRKQVHLQTATEEGSVQSSVTANTAGTPASNDGGISQQNHMQTGLADRSGGPQPRKQKIGIQGWNMAQFGGRKRQPQPILRPSRFGTSPPHDIMANWQVQLDAVRAAEEDVSIASTQSSNVQVGREVAVMHSQAHRGLRYKDSGDLVYLDSNDYKDGKIPEHVAMHDPKWFRSGATGLSLDTGSTFHLRKDSMNAKMGTLKELPYMFNYGTNVGGGRNLTHEVESKHMDNMCKYDADAICDVDSASLLVKEGYRIVMDTDVDNAFIVSKDGNQWIYREKDGLYTYDPHEGESHCNVCMEIGPTGEACRSCRAHHGGFVPGESYHGGIDNTTSQHTSRYSGLQTVKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFC0</accession>
    <name>A0AAD2FFC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1908780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000012">
        <property type="entry name" value="tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="9">
        <location>
            <begin position="144"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1908780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="477" mass="51275" checksum="79319DD55D423336" modified="2024-05-29" version="1">MLAQGFSISRRTATAATTAAATSLRWRLQPTYNRPLSSTSSESSSESSPTTESDEDQQHLIERLKRKQAKAAAKAKAKRQKFLGLAKAVDRGQFSVTYQPGGPNGDAFQNKSGLPTLSLPFTVLGIESSCDDTGAAVVRSDGIILGEALASQAEIHEEWGGVVPGLAKTAHEENLDQVIELALSRANLTIDEVDAIGVTVGPGLEICLRVGCNRAKELAIQHKKPFVGIHHLEAHILMARLENPDLQFPFLSLLVSGGHCQILKCMGIGRYSVIGGTLDDSLGEAFDKTARLLGLPVGGGGGPAVEKLALEGNRTAVPLTVPLLQRKDCDFSYAGLKTNVRRAAEKLVMERGVELPSELPRGDKADIAASFQHIAIRHLEHRLKRAISNVEDEEIKTLALVGGVAANMELRSRLEELCENHGWSLAVPPPRLCTDQGAMSAWAAVERLKLGSSDEPDGQDVYARYPFSLSAENNQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHM4</accession>
    <name>A0AAD2FHM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="152" mass="17709" checksum="2E810299B23D28AE" modified="2024-05-29" version="1">MTIQKNELQRLGRIRFALFLKILLKLIDSDRLVQDQAKLIVSACIRQHRNGSNKYKNIMDAIELNLRGLVQENTWRSARHYAKVFERKHRNRIQHHAADDCGDQDLLEIEILQPFETNRSNDFEDCYYNDASQIHIPPEPETIGSSPATPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHQ8</accession>
    <name>A0AAD2FHQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS2932</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHQ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1932629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="33287" checksum="B6D5F984BCE546F5" modified="2024-05-29" version="1">MAIKNSLTKAAFAEFIATALFVWIGCGSALATNKWGSVTSGGDLLTIAVAFGFAISLLAYSIGHISGGHINPAVSFALLILGEIDAKTMVCYILAQFGGAVSGALILWGCVASLTQACDDYDDPSSVPVCAASAFPGGRDGYGPPFRLGVNSLAPRVELGSGFLIELMGTYLLVFTVCMSAVHKKSSAGNAAPIAIGWAVMTAHIVMVPFTGCGINPARSFGPMAANSIGGVNTWSTGWWIFYVAPFVGAGLAAMTYRLIFAEDGKEDDDVEKELSSPLTEDEESLAASIFNSAFAEDEEEDDKTKERKIPESHREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIF2</accession>
    <name>A0AAD2FIF2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001072">
        <property type="protein sequence ID" value="CAJ1941753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="534" mass="59813" checksum="A74CD3873DBA3EFE" modified="2024-05-29" version="1" fragment="single">TPGLPQDQSPYRSELIGLLAGIMAVDWLLEQWFPNISIGPKVRIACDGLSAIEMAFEDRPLSPTDAQFDLVSSIWEAILRSLVDWAPQHVYGHLDKSNLFDELSWWEKRNLEVDGMAVEYRKELETVPDEIEVHGDEATLADALLDGRLRVISDGSFKNELGTAAVQILVKHGGCHRIIIRCQTPGLPQDQSPYRSELIGLLAGIMAVDWLLEQWFPNISIGPKVRIACDGLSAIEMAFEDRPLSPTDAQFDLVSSIWEAILRSLVDWAPQHVYGHLDKSNLFDELSWWEKRNLEVDGMAVEYRKELETVPDEIEVHGDEATLADALLDGRLRVISDGSFKNELGTAAVQILVKHGGCHRIIIRCQTPGLPQDQSPYRSELIGLLAGIMAVDWLLEQWFPNISIGPKVRIACDGLSAIEMAFEDRPLSPTDAQFDLVSSIWEAILRSLVDWAPQHVYGHLDKSNLFDELSWWEKRNLEVDGMAVEYRKELETVPDEIEVHGDEATLADALLDGRLRVISDGSFKNELGTAAVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIR4</accession>
    <name>A0AAD2FIR4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIR4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="293" mass="33175" checksum="5F8F8421032217C5" modified="2024-05-29" version="1">MHVQHHNTRQSKKDQRQTVARQSKFHFPGFTSSSEDDEPPAAVVTAKKRKRRVSSSASNNKKRKKIGTISKRSTVSKKGNSRNHLEKVQKKLSCIPKPSNASPAASVLTKKQKHDAKLEKVVDNSVELIEDPPTIRRTTSPEVNAKLFDRDPPATTLTPNELFLEEEEEELTSSFLLDDDHDNGDDNIDDLPLSPKWAKVRPISNTKYTSFSFILLLAFAVPYFHHMGGRDDSWSSGSQQHVVRKLQGVKNQDWKKLANPEHNVFSEQTNASSKDQQHCFSTDSLLSSYFSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ88</accession>
    <name>A0AAD2FJ88_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001247">
        <property type="protein sequence ID" value="CAJ1944755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="44" mass="4901" checksum="7759AF77E6EF3EE2" modified="2024-05-29" version="1" fragment="single">MHGNAGGQIRWYGLLEGSEVHKAVFLDEKGEEMDGWAHVEEGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJU7</accession>
    <name>A0AAD2FJU7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001219">
        <property type="protein sequence ID" value="CAJ1944183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJU7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="136" mass="12744" checksum="24C3CB1293F767E8" modified="2024-05-29" version="1" fragment="single">ICQVGPGVGPDVGPDVGPEVGPDVGPEVGPEVGPEVGPDAGPLVGPLVGPDVGPLVGPDFGLDVGPHVGPAVGPDVGPDVGPEVGPLVGPEVGPVVGPLVGPDVGPLVGPLVGLEVGPEVGPDVGPLVGQDVLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK60</accession>
    <name>A0AAD2FK60_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="250" mass="28189" checksum="D03391F0460A8E75" modified="2024-05-29" version="1">MQNNHNTMQVSDLPSIYPEQGPSLVKKRKLSEVNPAGAASAGAHTHHRRAVRIVGRSNSQATNDSTVDPQISLLSMLRRQGVDGTTAIAVEKANTFFDDVITEAELEAYDQEVLRAIRDSDLETLRSFYKSNRPLKCSNRFGESLLHLACRKSLSPVVKLLVYEAGVPLNIRDDMGRSPLHDAFWTPTVNCELVDLILNKCPDLLLLPDKRGHTPLNYARKDHWPEWNKYLEDRQHMILPKTLNLPMCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN30</accession>
    <name>A0AAD2FN30_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN30"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121252" checksum="D798E2684418E2BE" modified="2024-05-29" version="1">MDVEQHFDDDEKVQEVDDTTTDDDDDDDDHAVHDLGASASNSDFDDEQEYGDEYGDEIGDDQKEIEFGDEYGDELGDEEDDAEYGDEYGDDEFGDEYGDEYGDEDGEEPSDDDVIPLPVGETSEFDNSTANPSSIPAEQIESSSDVPLLNDDKPHDAIPSEGCSSMDKDAENDLTPTSRMQEESQTMIPPPPVDTTDASQPPKEDIHVPSNNGSSNLSLAEMIAARKNSNAPSPVKDEETETTIPPPSVDTADAYQPPTQDTHVPSSNGTSNLSLAEMIAARESSDSRKESPTLSLAEMIAARSRTEKATESRMNVVTPTKTPVQSQSNPLSRLKDDANENDSSSLSLAQMIALRSSGKKVDQAQKPQASASPSILHLIPPPKDKETLGSSDQQDSSSMSLAEMIAARSQNGTATKEPTPLNGKQFSEPMGRKQSHVYKNRSNVIQQQQQERRRKPTRKPTNGTKRPPTTSSKPVEKPRPTAKAAPASPPPQIPCTIHRRQNASFRQKHHVPWRKFEARRRIEMRYRRKIVEQEWEGAADILHQGIASTKLAERIIVGFVKASQQLASDFKATSEDSVFNDSGKVVQSSFTQRRLSKIRDSSNDITGIFGSSSPILAACLECYGILAEQAETLEEVSRQISAEYFPRLREMLADLEKAKTESESKVKRVVEEFDRYENNTASSWDSFESLQPYSPEQKQRVESPRNITQSDGWFIQQSYCHAVLLQRGYLLELKAKMDGVCNRVVTLENYRLGEVRSILLDGFYNKQLELFQQLPLFENEMVKNMTDARIDEESLEEILHDRSKTRLKYSQSHRSSILNRSSLKISEKLESDTVPSIESEFGSPLESSAVLLATVVELQRSGTTLSTFVSVSWKRTLAVVLDTEIVCFLELPRGQGQTEKESVEDAFHSLCPYFQLDTNTQRKRQDLLDNLSPFLTWQLSKCSVDISNIQDKTVEVTEAGRRRSSSNLLLPLVKRGEDGDDNETDDGSFKEVETKYALRFFSAADASKWLGAFEKTKGKLHIASDESISASSSISIGTSGDKTFGTFEGEGGEDDDSNGTQDGSTASKSIGARDENGDETLNGEDGKLSSVSLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN62</accession>
    <name>A0AAD2FN62_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="395" mass="43431" checksum="DCACC11C2ECC609A" modified="2024-05-29" version="1">MGIEKLVFKSRADKASRRLRCGSLPLKKRRFRLNFIDDAPDSQIVAIDSSYVNDENSDRNSSLFTPKSSLSCTLPQTPKSVTQASEPSSPNSVRGRFPENSIMGTTSTNLPRLVTPLPNGCHWRTARNKSYCRRRPCYNSSNFCKLHYQQCTNAFRHDPSSPTDGNKAETVPQHTVALLKTSPELPMLPNILHQDKRFTEAPGEVNCTATTTRGRRCAYVAVNETKFCYLHSHYDKSRPASRRNSCNMCVVSSNPSSSLTSQSSLSSLPTGTWLHRSVLIATGPLQGRTGTVEKWGNGWVSVGVPGVGLHNRRSFELLLTAPIDGIRTNFRPNLRPAQSIPSSRVTRVSDSSFSSDGSSSQTRSMNRSIMQVPVPTLIVTGKSATQNIINSQAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ39</accession>
    <name>A0AAD2FQ39_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="501" mass="55193" checksum="DC969E9D8372042F" modified="2024-05-29" version="1">MVPINYQHAVQESHLRRLEQQQHHQQQQLVSAFSAYAGRPIWIPSMVSVPASEPSFLSCQTTQTRPPCPPTATAGVAAQSTTTTNTARPMATPSQAQTTQTQAQPAPSADEVCAASVLISFTPKEGTTVSNAPSPVPSMVSEAVVMPKSLRDSPGHVTDSCTSSAASASNSCNEEDASVCHSAALGSTAENFPSYPPDQKWHSGCISLSLPEDEEVLSPLHCFMRRYCVEAFTAAPQDVATPRYGKSHGLKVVTGQVGIRCMYCKHRPVGKRPERAVCYPSSLKNIYHSIETWQRRHSLVCPDIPSWVRQSMVDLMESSKSRAGGRRQYWEDSATRLGMVDTSSGVRFIRQPGAVETAPSINPTGFVPNKVVADDDKEMVTDYLFLLMDQMETCQFTEEDRSGGRSKIKNNTVGFPGMQCKHCQGKAGFGRYFPSSVNALALANSDRNINNHLQKCRRCPTEIKQELARLQKDSTQGKNRRGLRKLFFRRVWERIHGPMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ69</accession>
    <name>A0AAD2FQ69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ69"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF8">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042130789" description="NADP-dependent oxidoreductase domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="65"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1948389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="351" mass="39542" checksum="2AFFDB85E56D0550" modified="2024-05-29" version="1">MSLSHLFCIFFLYTTLAPTVTCLDGGATTTGKAPSKRTLSPYDNDGHPTDLGSSFPRLTYGTAWKKDATTSLVYQAIHAGFRHVDTACQPKHYHEAGVGEGWTKAAHELGLDRSHVWLQTKYTSVSGQDPSRIPYNPEVSLRDQVHQSLQASLKNLQTNYLDSWVMHGPESSWEDNFEVWTAMEEMVDAGLVKQIGISNFYDPGAVKYLYENARIKPAVVQNRFYGDTGYDVQIRQFCLDHGMEYQSFWTLGANRHFLGDSRVVRLAQKRNLTPEAILYATALKLGITPLDGTTSVQHMQEDMALLRRLREGGEEIISDREIRILTRILGIPSEGEADSMDEDEEEEEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQB0</accession>
    <name>A0AAD2FQB0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycolate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF93">
        <property type="entry name" value="FI11325P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041953030" description="Phosphoglycolate phosphatase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42542" checksum="F1DEF022E195FD78" modified="2024-05-29" version="1">MVYFNRFRSIAALMVLNAPKCSSFVVANNNPARSSWSSSSTTTRRGVGFFSTSDTTTSSYWNDAAIATNQVEQFYDSLSKDTKVPTIWKSREEASAFLTDHIDTVLFDCDGVLYRTQEACPGAKEALLSLEAMGKKVLFVTNNAGVNRQGLRTKLSKVLDIPSLTEDQMVSSSYSSARYLQEQLKPKSRIFVIGSPQLRAEVESAGFIITNLPDSSSSSASMDREELEAYEFNEGPIDAIVVGHDTEFTFRKLCVANNLLLQNQDALLVATNHDSFDIVGSDNRHIPGNGCVVKALEYCSGRQSINVGKPSKMLSDLIAKDHDLDPTRCLFVGDRLDTDIRFGNENGMASLLVMSGVTTAEKLRQLGEGTTEEPLPHYVLPHVGMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRH1</accession>
    <name>A0AAD2FRH1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="202" mass="22429" checksum="391BAB1FAB6EF813" modified="2024-05-29" version="1">MSHHPLHVSIIYAPSPDEPIVSADQEEDCAAYQYASRAKEFLLTATVDKAVNVTISRIQESSFEDASTCQDPNILDVDNPKKMLLVLLMSCSADGSIHRLLRKATKRLTQQDSNDGSSSSRIIQSVPLAVVLLGHARCDNSAKQMKDTIFGSGRRIEKALLNTNNSPFASIQQDRLETQVELVGPEVDFDPWWSLVIEQCWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSZ0</accession>
    <name>A0AAD2FSZ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001801">
        <property type="protein sequence ID" value="CAJ1952145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSZ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="26700" checksum="CE6359F88B05139C" modified="2024-05-29" version="1">MSGQFQNTGRGSNGRNAGRGRSQQGRGNGQYNGNKSGNGSQKEKKFHPLTRGNIPKFSFDEVKKTLVIKMSMMKMDHIDDMIQSVQTLSLFYIESVKPTLVLVTNDSDPDKGIKNEERRTNYLADQKDWKARKNAFDNNKPNVYGMIMKMCTDHMVDKLEQEADFENKLFNDPVELLMRIKKFMTTTVDTEWEYFGLWKTMSNLINCHQKEKENIASFCKRFEERAKALQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUT6</accession>
    <name>A0AAD2FUT6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001843">
        <property type="protein sequence ID" value="CAJ1953817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="70" mass="7376" checksum="FA723EADAE55F5CE" modified="2024-05-29" version="1">MSKPPTSVAGLACVVMVTPPMVTWLAWFRAGIVPSGGFRTCGGLVLAREPALVAGCWRVSSRSSERSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV44</accession>
    <name>A0AAD2FV44_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1380"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1654" mass="180607" checksum="7E96C99FCF16558F" modified="2024-05-29" version="1">MIGDGHIFHPNTSALAQLFWAPCNKNCIAMKEEVQNGPLMDQHQRQKGYNLPPVKTVFGTVEEILEQRTEESDANTYQDGSRGVMSEDEISGMVQDALFKARKATQSLSPHKQSSGAQKPYTSFFPSLENMISTSRSTTLQHAQSLLNGKTTVSPSTDSQRDQPDGYVIYENPSEQTGGYGGVEHAAQSAAMKYVQTMSPSANMMANPSDYVIRKVEDEIANAKKVAQEAFNRVKCGGASNEEIERNPPQIVDLTDAEDVQTFDDRETIQLAASSTWRSEGPNSTWRSEGPHSTWRSEGPSSTWRSAEDGEEPLDSMVLDSMVSEDYGLVYGYSVAPSMSSIGQPTVFCSLDNPIIRAMEHTAAGMNIIDLTNHVEYVSPPRSRDAQLRAVSPTQNSVTSVGSEDFGPLNAIEKVDTSEKRDMKKTRVKTYPILPLSQETTVKALEDSRKSDTEKADIKMAAAVSMKQESRADRLRKLRQPMHIVKEDSHEDSQGNPDDQDKMTLDQGTEVPANDCMDKEMVAKKQKDSDDKVESKENQEAADEEANDESVTEQQAEKTFTNSVETAEVVNDSHISKEEPVVTEPVESKATCLDENEVDAEPVTDQQVEEALIDSVETAETDEDPHSEKEESRTVKTETENETLIDLGETTEDVMEDSHNDTAESRTFRAETARDATDEGPLDLASGFGKLMSLFQDRDERKGLTFRAKSKEIGSEDNAEVISNDASVAQRPDTQAEPSTEDVNEENIEVRYDSDEVECPDNFETTSEKCLEGEGASVEESANDNTADAENMTMDEQATNIQPEGVSYVTPVQSPRNAADVIIALGGFFGGASHDNGIPVSAASEGANANALEKEPADDPEVQHDTAADVNNALGNFGASHDDGIQVAAASKGRTNADAVEEEPAKDPEVQHDTAAGAINALGNFGASRDDEIQVAGACEGHANANVVEGEPENDPEVQHDTATDVINELGNFGASHDDEIQFAAGREGHTNVIEEEPANDPEVQHDQHEKEAKHPLFAFFDAAREARARDFAALGLGFMAATEKQTESKAPLPEVIDGSMEGQQFSAVLAKSGESNEKNSLIEVAPTTPSMDGQLMPSPVPSQYTAEDNEYCEEEETSTHNVGQAEDVRHEAEAEQHDNEESTPPFDPLGSLYRTCVPEKELGPESTRVSLKNKYSDPPGEYTTRSEEDIINANRVEAPIPQLCVLEPTDEIQKLQASIMGESVTRRFNACGALKMFAMNKSNQLALARTDGFFDALIVALTTDLVGKDREAAFGTRTRALEILLRVCMQKENRVVIFYHPDLVESIVCCAAEDSGEIRMAACSVLAMIAKSGHLREPMAQVEDLLDVLAASLLGTDSQKAQPVKQLDEVHENDANYASDEFSSGSDSSSDASSSLESEISYATTSGRNKQHRQSTKLKQKEMEEKKKETKKQVTTNACAALLHLSKQCAAGHFMCHSTSLLNALLILSQQYEHPMHTKCLEILCNLTRLPSNDEILAEHPSVVPVMLRLSTSEREEDRVWALRMLQNISASAAGKHVLVSAFALELLSMSVLRTQAEEQKAAMAALFNLSTDPGCLMAITNTSDVLSSLVLVAQDMNTISEVRMMACDMLATIGLWFQKIAGGSTVPDGVKETVLPSNVTTGWKRWDEEIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVC1</accession>
    <name>A0AAD2FVC1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS14698</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVC1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000048">
        <property type="entry name" value="CCR4-associated factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1954103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="353" mass="39496" checksum="D4602030C25C0925" modified="2024-05-29" version="1">MAAMTSKSTLSTESPPFNPNRILAHNTPSPRRFNSRSRSSSPYRSASAGSYVKNDHPNSNTIPKFKFEHKGETLEIRNVWAENCEEEMRNIREVVEKYPYVAMDTEFPGVVAKPVAESYTSGYHYKSLKVNVDLLKIIQLGLSFADEDGNLCKECPCWQFNFKFDLDSDMFAQDSIDLLVHSGISFTDHAMHGIDPLLFGELLMVSGLVLDDRVKWVSFHSGYDFAYLLNVLTTQALPADEKSFFELLKVYFPKIYDIKYMTSLLDGHHFLGGLSKLADDLGCERLGAEHQAGSDSLLTMSAFFALVKAKFTKNGKVDDKRYANELFGYGNNHTVRKGGPSREMSTGSAPGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVZ5</accession>
    <name>A0AAD2FVZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="212" mass="23595" checksum="CD2286D4EC9B433B" modified="2024-05-29" version="1">MPSITTTPRLSSRQTVRVFESNFLKYLSIYDGVIRNTITENELDLASTVFEDQVRLVPKTSDNTKTVSMDQLKAMMQRYLQSGTRFELLEVHLLKQSKNQKNGDIFDDETASSTFDDGTIRIQYSARLVKANGDSEIGTTRVTLSSSGRIQSVVDAPSSKLDEEMSINSDASSEENECRSEIDSSEFHLLVGFGSSNKANSSILLTPVFRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX35</accession>
    <name>A0AAD2FX35_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001876">
        <property type="protein sequence ID" value="CAJ1955033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX35"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="374" mass="41426" checksum="BA39F1699F16D1AB" modified="2024-05-29" version="1">MLDLQTNYCREVEYYPKTVSKAQDMLKIHMDVIKNPGLNLYQEKYQPNEDRLLPKIQWKHPDEYVDYGKKLNLNQIGATLPATVPAIVPGASASTSGASSVAGSVNTPLRLAGTTGNQMMQVPLGMQLMQIPTQGGGTLTVVKTGYYDTSNVFHNAIKGKDENGNDVYLIPCPAGTTNVELQADWHYAGEDEDLPDLPTEADRGLQFIQSCRRERDPFGLYNHVIMDSGCTNTTICNGELMHGLRHAEKELDLHTNVGSRVLDEEGFPPPVYYDEDGIANVLAMRKMIAAGYRITMDIDADNAFIVHCDGDRKMQFVNCKGVYVLEQLGAAAKETSAMYRRQLSNLNNQPNFELSSNKQNGYAGLRMTSKMATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX63</accession>
    <name>A0AAD2FX63_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001891">
        <property type="protein sequence ID" value="CAJ1955490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="107" mass="13007" checksum="B14B7F77412B807E" modified="2024-05-29" version="1">MRRSLHFKLELRQDWQLQIPNQEEKQRLVFEQKKHQPMEEEEIDFSDGQHGPLFNNNAKSDVANMKLNRDLQWRDLALQVTENIMENMAENEEPKNFQEAWNHPDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXV8</accession>
    <name>A0AAD2FXV8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1955968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="259" mass="29320" checksum="D77BA4025E4E6067" modified="2024-05-29" version="1">MCGAPTTTKAAVMTPYQRRRSDASSADHSVISAITMDEEFGSHHSRSLHRFDPKLRSLMEQKRSSDPDEEEVKQCLNELRVPGRNDDRFSSCSEGDKQLCAIPRRRMSVEMELCIKPAQYYSQYDGETKEDDEDDDASQASMETLEGSQYAYDSIEMGFEDEQECVYKVPMKAGEDNPNHEGRPRRNYRRRVRSGTSSVTLWVAASSSVSSDDSPHSPHSEGGRPRRNYRRRVRSSASSVASSIVSDDQSYGYNRISYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYE0</accession>
    <name>A0AAD2FYE0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYE0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="270" mass="30723" checksum="54A161AD8DA6E5B1" modified="2024-05-29" version="1">MTLKDLKLKFQKKQSSSTSSSVGELIKETASDEVEETEVTLTEEDEAFYGYNTFDDVPSTPTVTPKDSVDKYGYNTPTTSTFEDSDNKYGYNTYEEGVPPPPCTPNTPKMSRRSSLKGSSPTPRQFRRHSLTFSSNVVVATIIPTPELAKKKSLWFEDKDYEKMHKKIHLIAERAQEGEGHKYCTRGLENIIRGGSQIRKYAAWDAVLDEQEYQIQSGAEFYDEDALSRSYRVVCEESRAQAAMRALQDQKEAAEYLSEKPRRSRRSSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZH1</accession>
    <name>A0AAD2FZH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS16961</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1957957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="48149" checksum="6CA1F58E329265E8" modified="2024-05-29" version="1">MLTTKLAFQTFARKAAQSTAVHRGQVQPLVSGLWNNASLTISTAPATTNYSIPTELALPNSAGVRSFSTAATNTVGKLDPSVVNKIKEELKQVDTNEDGHLDADELMALFKKHNSAFKDAEILEARDMFYAGQAGGGLKFDDFIDILEKVTTKPQNDHPILNGNFSSEYIYRKSHAYTNEELAIELTHTPPENMRDRMALNAVKGVRAFFDTITGWNHKAMTKDMVMYRVIFLETIAAVPGFIAAITRHFKSLRRMEKDGGLLHLFLEEANNERMHLLSFIKMKNPGTLFRGSVVVSQFGFGTAFLGTYMMSPKFCHRFVGYVEEEACSTYTKIIDAIETAPEDSELASWRTELAPAIALGYWELGENGTVLDLMYAIRADEAEHRNVNHATSELALGQTNPYNDPEMKVSILLRKYVRDIMSRDQQLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G000</accession>
    <name>A0AAD2G000_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS17143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001972">
        <property type="protein sequence ID" value="CAJ1958345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-SPECIFIC PROTEASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1519"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1958345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1784" mass="200988" checksum="6A9863F6782734D1" modified="2024-05-29" version="1" fragment="single">HWRALTSDEITADSDGHKVKGEYDADSMAFVTAVVRDFRMFNSVEGIKFSPTHANRAPRNIRIAMPTSSRRNFTPCYADGSEPKKGSNTPTIDEFPGLNIAKVMFKGALTAHMSLHIISNGNVIGTSCPTALPRTWNFAFCEAIRNYRTTETFEAVEWGEESRKWQNGLAGKLYAFRLDGNNDVNVDASVYGKVSIFLLEMIFDVIKLIADGTWTASLIPEGVTSQAAKMIVHNSCLVVQAAGFKDCWPGMVATLDAATRRSMSLPPAPHLAMDRASWETYNKYLQNCFQITYKRARAFFFKKNVEDNFSDSAFCAIDIAVVFTCADLRYNLIPSGVAAGEIVRSAAKARKQNITMPAEDSDNEGEDVLDHSAEEEENGNNGRIPNTTLERDSESEDGNESESEPDPLFDQEIGANDEGDGNNERLPTASFDTTAEENGNLNGSSDDELLVESVVFDWLRAHGFRKWIRTRFPLHGTTGRIWSNFQQRPGVRLEVMITDDGRLIVLAYLSDRACPIVQIYEPSTRAGLQDKTEKDLRRQARQIPQMIARFVSEVEGIIAAAHSATKKKTNGRDLNMFELIRESFRVLDSWLERLKVHTMQTRYELTFATALANSDENEKISVPIADGETPVSCLSFVRRRDLYEGLKLHVDHHRYILVQGLCAMEKNPQLKELLPNPVWAAYMAAAEVLVLLLGAGAGSKWSILERSIQRAKSNEESAPNTPFHYDNNWWDVHPDFIQVVSTDEEWSTWACVTEGVDPSTCNIQMMDRRLRALRAVDDDDEGEEEPDEFLDWLQEKLPVHQIEGLKGLRNPTQYRKCVQMMYMEFIYAGDPTSTTANSMFQAVNWAAVGATPRAVVKLYERCANVIVALYRVELAERITAFWNSTHKRSLRGGFNMNDATKAIYRAKTKLQIIDCVLVHLDATWPSPIIFCPKPIGDAAEIYTYLTGYPSGSAFPTSVPTGQGWVSLGVPRALIALGRMCGMVKEVAEDVIRAFGGRNPFRDVSVFQHFLASELAKHGSLEDPAFIFKSRKSELRMEQSNCLLIAYNSSSEFTALTRPFVKKPETNPDDIQRDSFAGNFLTISHTRHFNLLNNLSRQLAEEHRGPFDQMYLTNGSPTHNSCWSCPHILLLQAYIIFFYRNQGMAYSHSQMIMPTDYSNVIGAIYTSPSKIKYVTKEIMKPGLFKSSLQLYQEPDTFEKLEVFAKTKWEVHGDLIRVAVKSLKSPKELMKVDTHQDALLASRPKSDTLSFHLKAIQVQMSDTRKADANRLSVATFIVSKFGIVSEEFLGLLESIRNDLRYHIDRYHKDPSPCNLDSCSEVVKRYGANKSHTYFKFDPAGCKPPPDHGGPRPIRTGHYREPIISTPEKRSLPSIQSQHDGVLGRDLGFHNTSLFHTPTNLKIPAVEIGNSNERPITYSDDKNEDHLGFHNKSLFHTPTNLRIQVVEIGNSNEQPITYLDDTNEDHPTQDGLNTSLDGYNQRQLPQGTKHPTATGFRESLSCHPGSMMVHRILSVPLSPDDLAIIKDKMESTDDPELKFKWLGLEGMDLASFWTLKPRIWLRGQVVDYYMKLLQIRNDTDYAGSGFCFLDSNFYTRLMNNGIRARRSPTYNRYNYELVESWVSGRFDAGVIFNHTKIIIPINQDDSHWICAVISLKEKNIQVYDSIRGKRAGPQIIQNLMRYLDDEHSSLHVTGLPNKEAWQSICTNADTPQQQNGYDCGVFTCLFADCVSLGVPMAFDQSDIDNNARQKLALAILNDRPILQPRAAQQQQPILSDQAISIPFVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G051</accession>
    <name>A0AAD2G051_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G051"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041973528" description="Coenzyme Q-binding protein COQ10 START domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27474" checksum="BC86CF7DA86E17F1" modified="2024-05-29" version="1">MMIQKRLFLTLLVLVCCLTPSWSKKDYNAPHGHQGLLKSYEPGPFDLVLNKKELDTLGSGKPVMKQPPPKEGELGGGAICVQDVDAPKEAVWAQILDLDSYKSKVPKLNECKNYFVNKMKDGTFSIKTKMVVGIIPGYSYTSFYDHKYSPEKDSVTWRLDYDKTSDFDDVSGHWHLEDHPDKPDCTRVFYACDVMLKGAVPKPIANYLSKSALKTATGWVKKESEKNPTGKVPKIFESSAAFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3G0</accession>
    <name>A0AAD2G3G0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3G0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1961419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="186" mass="20898" checksum="8B2CFE47C94FC7BA" modified="2024-05-29" version="1">MQKKGVTMNESVEVVEILHVNDFTASEIAASWYDEEEMKKITERCFKVLQRMEYGKTKNGKKKYCTRGLEGHTALGSISKKKTRAAAFSAVLDEQEKRWNENKDVDFQAISDAYRKVSSSSQMWAQVIGNRDHHAIEAYLYQDEEKDEEVDATTTTVSTSALKSPGSQKITLKNVGSIVHQGARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5C2</accession>
    <name>A0AAD2G5C2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Caffeoyl-CoA O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5C2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1963478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25480" checksum="CB1D083824E57013" modified="2024-05-29" version="1">MNSSTPRPAKFANPDFVAPAVHAYVQELGYKESPILERLRLETANHPRARMMGDPSEAALFKLLISAMNVKRIVEVGVFTGYTTLAMALNLPDSGTIVGLDVSEEFTSVGKPYWIEAGVENKIDLRLGPALESLDKMISDGEESTYDFAFIDADKVNYEGYYERLIRLVRQNGIIAIDNVLWSGRVVDPKEQGDDTVALRQINKLVHGDVRVEHVMLPFADGVTLVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5Y7</accession>
    <name>A0AAD2G5Y7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5Y7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1167" mass="133614" checksum="EDDC5531AAD955C0" modified="2024-05-29" version="1">MGKSTRRQSTSMLPSNFNSGLSEQEITDDDIYAAFGVTDNSEQDLRLDSDTPRTKRNKKVKKRQSAPARRLSVYDILYEDEEQYEIPDSVFDVELSPQANDKKLKRPKSTGNPVEAKILSLDEEPSLFDLLISPRENKDKYGKKKKKLKSKELVADLGKATVDEEESPESPSEGLLVLNDVSVDARSISMTKRSKKNKKARSNSLLVIDLGNPPKPVAESSKMLSSSDSQLFLNDELLEISPTSKARRGKRPKKVKSKSLVADLGDSTTEEESTESSSCDYLPGPSDEPLRVRSRSVTKRDKRTKKVRSKSLAVDLGEPPMSVTESLNLLSASDSQLFLSDESLEISPSSTTKGNKKGRKIRSKSYHMDLGNLTAEGEESSELLCASDCVIPLNDELLEIKPSIMTMRDKKNQKVKSKSFMMDLGESDLKAKKRSKSRRKECAKYRSDRDGVDQEILPRRRCRSHSPHPRRSLIQWGEHQLHTIAESSESEESDDDRWSSHSNCDSPPHAPRKRRKRHKSCSPPLARSPNRLWLESFDATLDESGKSENKAKKRKNHKSKEKSIEKPIEKNEKPSPRLPVDSETPPTADETRKSNSKQSAKPIKSSKESKKESTKRDKRKSKRKESNRMSTTSLDSSVDDSLESSIDSIASSKGSKTEKKKSKSSRNSKLSSLNDSMEFTEAMAAAEEELMRATEEARQKTGQEIAKLRAGEEARKRAEQEAAAAKLRLQVAEVRRKVDEEECQKAKKEAQKQAEKDAMIRAQEEERRNAEREEERQRLRAGQERLQQERDELERLRKEEKARLEKERVELQCQKEEEAQRLAMERADLERHRYEEEERLHQEKVEHERQLRDEKARIKARQEAEKARLKAEKQERERLIKEDKLRLKAVKDERDRAAQEKKSRIKAEKDAEFARIKSKKDAEKARIKAEKEAEMATMKREKMEKERIAEEDKVRIKAEKDAEMRRQMELSERKAANEKPQKGLAKPDLVGRNYSIDSLFQGSIDNSLHAEAEAQRMIKDRERLKQEIANLERQKKAAAARLERRAQAMKNALKAAEAKTNAAELDLEIHSTQERPEEEEAARLELNVDDERRERAPSPVTGEEEKELSRKESSARKQEKGRRMEEKAADDYRLGKLDGRRSLTKNDRTFNSGWNKIVVSTKKKFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6E5</accession>
    <name>A0AAD2G6E5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS20716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6E5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1964612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="599" mass="66062" checksum="83EBFB5B565DCB72" modified="2024-05-29" version="1">MEPVMSAPESTSSQVDHKEQGVSLDQHQDDTTTANHRQEEAAASSPIPSITRATTTNKSSKNELPQNYYDEEVASDNQVNPLYSMIQKNQSLDESALEINHLSTSSANNNSVKFARRLSSPTKFNLRRLNMAGIMVSAVEDDSTPRLFANSWSFGSLTKSSSRLDGVVDDSDDDVDEEEAMEDRMNVPLHKTKRESNLPPVNSMEFNLDMIELAPSDDNKNDVTEEPKVDKEDTSVTQLTDVQTDSEYLEDSDERNKEKAEIHHEDIEASSDFHKLPEQHSPSDDDEKVGESKKKPVYFIGWCAILLTFAIVIPLAVVSMAQSKQDELQSNPMASDGPTNEDTVGSLTNQSFPVSTAPSLPQPTQSGMPTQSYSPSVFPSMVPSWNPSKKPSVSPSTSPTTNPSEIPSIQPSMEPSTKPSIAPTDHPSMYPTVLPSPVPTGVPTKSSSPTQLLCEIRESDGCEDYYHPTGWVKDLSCTVSNGFLTCSIASCYDFRPRDWPSWNILITNAIQNTFRIRQDDTQASVVLERRNFDGTWTSMNYYQVKASASEVVFGLPIGAISDVEKLRTWLVSYDENGMDVDRIPRVGSLLFTGAGDVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6G5</accession>
    <name>A0AAD2G6G5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6G5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042032770" description="Helicase-associated domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="136"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="211"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="292" mass="33754" checksum="E0F11C5BD423C7A3" modified="2024-05-29" version="1">MMSSFLWLNSIYNCQKSLLLSPTLLVLTAFAQSISNNPSTTQTWSSQIASVEPVPLSFQPTPKPSFQQESREADLIQSALSILFEPADAIVRSKRSTDNLLSDISAHSQESNKRPRLLGPQEVFSDQTVMRFRPYQDQQWSGMFQKLVQYRLKHGHCRVPHSYQEDRMLARWVKRQRYQHKKLKSNDPSSTMTAHRIQQLESIGFVWHSHASAWQAKFEELKAFKQSTGHCNVPSDHSNNSSLSAWIRCQRRQYRLWSYGANSTMTEKRYEVLKSLGFTFEKYGGLQRSQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G707</accession>
    <name>A0AAD2G707_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G707"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="164" mass="17512" checksum="916E58C76DF92CDB" modified="2024-05-29" version="1">MSSAVSSGSDTNNHKFRLPVPKRFHNNNKSQSKTERYFRNGVEEDESTIVMTPTQPPPPTRPAFVQSSSVVQPMDITMPVVVSTAELSPIGGGGGAVTDNVLRTIDLPKHSSPAAPTTTSTKNNTMMWDLELILGRTAMVAGLIMLVGEVFFGVSPLVSLVGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G871</accession>
    <name>A0AAD2G871_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G871"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041933156" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="120" mass="12784" checksum="4AAC698DDB693E9A" modified="2024-05-29" version="1">MKFSTIIALIASSAAVDAFAPTASYIQISRTSLAVAQSPPSDPELADAIADVRAAAKDFGDETEHFANVWIDRVLSGEHEGVEAGLLDECVIDDSDKCQRFEQALKRLDALLGVGAGEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8B3</accession>
    <name>A0AAD2G8B3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mob1/phocein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002243">
        <property type="protein sequence ID" value="CAJ1965978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8B3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25629" checksum="172FAE186ECB6AF7" modified="2024-05-29" version="1">MPPTSTGTFQPLRHRSGTMRERLHAYTKRTLGAGGSYNDAVALPPGESCAAWVAVHAVDFYNDVSTIWAVMSSDPYLNSFRPGEGFPSGVEYRWSDGPGEALSVSAPVYIEKVLGWIADQINDETRFPDDDDETEALRVFQTPQFAALCGQIFRRLFRVYGIIYSSFFGTLEALDMAPHLNSCFKHFMFFCTEFGLLPEREVEPLEVLVKPIRKKYYAAKQGGVTSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8S5</accession>
    <name>A0AAD2G8S5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxisomal membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8S5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041912527" description="Peroxisomal membrane protein 2" evidence="7">
        <location>
            <begin position="24"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26614" checksum="22D8F94FD168529B" modified="2024-05-29" version="1">MKIFQSLGLLFALCSVAPISTVAFTTTTPSTTSMMTQRLSTSSSSSLHIAGVQEAWTAYNDALEANPLLVKSVTASVILGAADVTGQAIERAQPESDVTELDIARTVRFAFFGLVLQAPWNHFYYNFLDGAIPPTEEPFTPTTGIKVVIDQFVQAPIFTVLIFAFLGLLEGKTTETIKKQLDEDYADTMVANWKLWVPATVVNLAFVPPILRVLYLNCVFFFWSIFLSLKLNNKDENEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G938</accession>
    <name>A0AAD2G938_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS20642</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040002186">
        <property type="protein sequence ID" value="CAJ1964459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G938"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1964459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="272" mass="29856" checksum="DC308DADCAF10BD9" modified="2024-05-29" version="1">MFVSRIGRALSSQPVSLICRQCVCMMSTASPDGLYKLLDTGDNVGNSIPEAMFSLYNADAVCFDVDSTVINEEGIDALAEYLGKGEEVAELTKQAMDGDTKFQDALQMRLDIMKPSKSQIETLLDEQPLVLTDGVANLVKSLHEKNVDVWLVSGGFRIMIEPVAEILNIPTSHIVANQILFDDNGEYKGFDKDEPTSRDMGKPKALEQIKAKNCYETMVMVGDGATDAQAKPPAAAFIGFGGVVEREAVKEKADWFVLSFDDMTKIVRMRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9G4</accession>
    <name>A0AAD2G9G4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9G4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="3">
        <location>
            <begin position="60"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="239" mass="26494" checksum="F1B2D0A40B6E84BA" modified="2024-05-29" version="1">MNNLLDDTDQIITVATSVAFVAAPLLYYRITNYFWNRHNKPHPLATILKAQGNQIKPPFPQTVRDLLSKCNLAYLSTIDQDLSSSHLSLMRFTYLNDPDDGEVVIMSTNTQTKKFGMLQKQKGVALLIHDFGSGGNYECGAYSITLNGECRIVDAPQKAEEYRQAHLKHNPEYPQFIVGEHIAILCIDVKSARICNINDQVIKWDVSDNHIGTASGNRTATAEVSTNGSSKGAPTVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9M6</accession>
    <name>A0AAD2G9M6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 tri-snRNP-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS22490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9M6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1966904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="84290" checksum="4D34C81346D67095" modified="2024-05-29" version="1">MPEEVIELSVEETNKLRAELGLAPLRLSREPVPFQSIEEQASRNEISESASKADEVLEMSIDETNKLRDKLGLKPLRSGSGKEVVHKPATNDGAAKEAAARISEARLQRDVQRGAAKTFGSQTLSDDADKSALSWAEKMRQQKDEAPKKSKTKKTTKTNERYDDNDLEGMQVSHKMSELEAGSTTVLTLADAPLLEKNESNKATGLNEAEDTLENDNLRDQKKQQDGLRKKRMLEMGMGRAGGYAGFDDEEFEELGGTLGPSRKERGNLFLGDNEDEDQPSRLGFRLGSTREKEEKITDFDAIQRGKAISLLPTKADVAASDYMTVEEEDAERAKRKLKKDGKFKKKKKKDKKSKKQRRRKMDSDDEEEKVEAPGTQNGNLLQHLEETASAEVTGMRKRRKVDEEESNDHIMTDGDVKEEAREKRARYDDIMDKGNERTRLAFQEKKKPKVEEDWFDEEPDDSFLNAALAKARRLNRLRELNKPKAKGADAVAAALKQSEDAAVKPDHAPSSSGISFSTDDTREFTRAIQARAQQEERSKTKPAPNTSGIKIEIKSAPKDIAPKVEDVEMKEAEEEENLDIHELAKEVDEDDTPALEGTASEAAGVGRGLSSFVSMLKQTGEIKKHAGKEELRGRAKDERNYENYEALDLKKVVKIGRNANDKDKEFAGREIKLEYRDKHGRLLTSKEAYRDLCYQFHGHAGSKKKEDKRLRQIQREQAEARMASKGTTAGTLGALKKTQKATGKAFIVHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA22</accession>
    <name>A0AAD2GA22_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677:SF59">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="362"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1967372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="529" mass="58101" checksum="F9489AE1D7DCEA9A" modified="2024-05-29" version="1">MTVSLRLQVCSIVVFIASYTSSFHHNSLKPRYQLGPSIFQPPFNKNHQYDGILLRSSTLEPEAAQVYGITASGEPCKRCQKLGEFCWQHKWQETDKSSENSMGIFSDSKTTLALCLSSCAKRKACVYAIMGLLTVLTTMSLAFRNYVPRSSVTQSIKTVSTQVLKQHNVTASILRLLPLGAFAFGLAFLKFLMGRRVDTVDLLRTVDSTVQKVRYVGDLPSFQTPLSRFEPEPVASSSTGSRQAMKVPTRQKIFYGRPASQLMARNNDDSDSESMDKNNDTGDFTTMDAIKGAIPLLVLVVLASKFETFLHLSQVLKANVNPTYIRDTMVPILDRLNGAGTKGQVIYTLSLVLWTMTVGVTTPIETAAGIAFGTKKGIVCNALGKTGGAVLSFVLGRYFLYKYVRSKLKDNELLGLVEESIEENPLGVSLMMRFAPLPEFAKNFGLSILKVPARWFAVAVLLHGVPFTCLWTSVGAETASVMRGGAPSATLKILMTGVAWFGLISPTVIGLWINSLRKKRIEREEGNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBW8</accession>
    <name>A0AAD2GBW8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="396" mass="42768" checksum="B69A26C7038DFFB8" modified="2024-05-29" version="1">MGKSSKQSKKAGSAKAANAKTGDQVKSSSTKQQSNAPVSNDIAAEHLPPIGLVFTVIACSGFLFVFFFRDVFATGRVIGGASDQALLSFTKSLEFFDDSKGWSSTQGGLSAIKPITTDANNMGSFYVRKMAGAAGMTLQIQKMMPLLIHPRNARWNMGHFIPLLWTASVTNLLLAAFYGSCIFDLMTADAAFLPTIFIGILMIEATVMLFYIMTFGQAKRGPAIALKQGKTPTSVVSRIVARTVFLVSGAQMLFAARDLFYPGLIMSYVPGDDVFLEWVGALIHSPPEGSPEEEEYGMAATLHVGDKFASQLLAANMLLLCMYKFVSAFLIRYGSDGGGLVKAQMIWKSQAIGGATNLLLVRLFTSAATSASVDIRWHVMAIAYETFILGLHGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC45</accession>
    <name>A0AAD2GC45_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC45"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="54"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="274" mass="30885" checksum="E5617636968A2CD4" modified="2024-05-29" version="1">MKPSSTGEAPSEAPKKSALVSISKTEAAQMETQQRKASIRSSPNLSSVAEANNILFGRGKRFTYHPGNQRMRRILDKYRSQYFGASCAEKRKLIRKAYEEIIEGGVKFLKPAGREDEWVEVDVELAIQKVGHSLRCRRSFKGNIQESLTPRKAPTRKLQKGAMPQTTSAGPSMFQESQMQYMIQTSITRPLEDELLLRRRIAQQRTLELGFSLLPNPMTSLLVQQLQLERLGLLPLTARTPTIQPGAFSQEALRVIEHEEELLRLMSSHGSSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCR8</accession>
    <name>A0AAD2GCR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002336">
        <property type="protein sequence ID" value="CAJ1967540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="26294" checksum="CEF2971BED31E107" modified="2024-05-29" version="1">MDYSNYQLGMITIQQNNAAVSKLKDGKVIDAFHLLSKACQGAHAAKTEEDSNYDRSYRYTWLDCSRALARRMNGTRKFSDGSLPFLFLQFLWIEPPEGCYAVSEEKQTSVHVRGFIWVLWYNLAIVSILLGNPVEARGNHLLTQSLDLFRLVQSVVDPQPFSKHWLILKLSILNNEACVLSDLADSHQRLDRLIQMGLALGNMSHLLDPQDREQFVWTVKTMADDRYAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHI2</accession>
    <name>A0AAD2JHI2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="18"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="949" mass="104950" checksum="02A012D3B47447D3" modified="2024-05-29" version="1">MTKDDPPPMKSPPTFQIKVALIGNVSAGKTTVVNALFRDKFGEVSMKRTTAGINEFAISSRNEWALVSEAPRDSHSVLKEITQDNLELRTSEEVKTKRFEIELDEALCDMRKDTQLVVVDIPGINEADMSKKYKNYVESHWNTFDCVVVVMDGRQGVNTEEQVSLLRFAKSNLESKKDVPIVILCNKIDDQDDEEQEELVLEAQREVEKIFGVPDRQKSLQEILKKCVSSKQSADSTEKQEPTDDHSKPSDQVSPVFIPISGITAFIFQTCSNMPLERFHQFDQKLIAKLGRDRIGKSRWKKLSKDERIKEAHEAVSDPEGYQEGMADSNFDKFLTVLSFLVGGKGNQQKMIQEQIRVSLSTISSGPGIVEKLETIYKTAKALPLGDAGVNPYLAEIKTTFWRLCKGMEQTCFVKNTASKYLDSFLTLTDELKKYRDFASKVGWDIEADASVAFLRRVVGRFLQNMDSTPGFAKELKAVHCAMKDVSSGSGDSLTDETLKQTFERLFHKLSEEKFAAFASADAVGNLSVLGDELVVYSKLATEAGWTSEKLKVAAKFKQLVLRQIGSLCELASNGPSQQVFGYPDSSRPASFAAFTWLDWKLVLRSILLLRYDRHFCLEFGREMVLMECLLESEPEVRAEKNDEQCTRCKSKLTFNRICTSCRTPVFAKLEDSPRCFIKNCSGTTRLHDNNGLVHCCSNCGSCTQYNTSVNLKREKKHMCPSCVGQELDYNRRCGNCHVFYHPHSEHATFSVCPIDGRALDASTGNCSQCGCIWEQFPNSQEGIVKLRYDGNGVVLFGSQHAVNVPSALSDPNHFGHLAWQYCEFMATGGVEREPDSTGDDASCKPPKSSDGIAASPALFQASGMAFTKSSSNTFDFGGGAAASGTTLPKSPTNLFVFGGGGTTLPKTPTNPFAFGGGAGKPLAKSPTKPFTFSFGAAAASNENETKWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHK2</accession>
    <name>A0AAD2JHK2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001785">
        <property type="protein sequence ID" value="CAJ1951534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHK2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27652" checksum="6BE87DEB6BD7CD46" modified="2024-05-29" version="1">MHVDESSYSSYDVIIGRDLQNSLGIDILWSKQSLMWDGISVPMKGYTERSDENEDELQNMFEEIMEIEQEEELFGASKLLDAKYEKADINADVEQMNHLSAHEKTALKSLLYKYEELFDGTLGTWNIPPVDFKLKPGSKPFHAKPMPIPLIHRDTIRKEIDRLVRIGVLKKDTSSEWSAPSFIVPKANGQCRLVTDFRVLNSMLQKRVYPLPKISDLLTDISGFNYASAIDLNMGYWNVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJX8</accession>
    <name>A0AAD2JJX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJX8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="304"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="406" mass="44953" checksum="9F5C604B929E70E0" modified="2024-05-29" version="1">MLSKTNLVSNSLRRRFLQIRSGSSRTAMLSWYPHESNGDDFDGFTKEQIQETMLMMLQKPETSTGFVPSAEMHLSNTRSIIADDENKMDDFDGFTKEQIQEAMLMMLQKPETLTGFVPSAEMLSSNNDNAIPDEESNIDFGFTKEQIQEASMLLMLQKPETSTGFVPSAEMLSSNNDNAIPDEESNIDFGFTKEQIQEASMLLILQKPETSTGFVPSAEMLSCNASNATGDVDIATANQTTSDLLAMLSLASSPESAIGVNHCSEYLNAEMKKQMSTQYENSLPKTLSEALSDPRPIVVTSAASPFEVVDVNEAWVGLCGFSREEAKNRNLGQLLNGPETDVSLAREMVANLRREHYSRAILSNYTKTGRRFENRVQVGTLSSDNGESIEYFVGLLEEIPQAQQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK85</accession>
    <name>A0AAD2JK85_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK85"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1957570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="434" mass="47679" checksum="C0D0BC054B85B54B" modified="2024-05-29" version="1">MHHPPLSESLNVVPSMNVEIEIPSSVTSIGMWAFEDCQSLAKVHFHHHNHHEDGAGADAGSSSSSLATMGDMAFAGCKSLTHISIPSSVEIIRTAAFCLCMNIHEIGNLRVIGQNAFDGCVKLKTISIPSTIERLARKTFQNCESLLEIKFQNGLKYVEDSAFHSCKNLQSVALPKSVEVIGTLAFGQCSKLVSVEWVGACSRGTEIQDDAFAECKSLINICLSDDVHSGGVSAGSFRGCTALENQYGDTNTISLALTHRFEDFPVHNKCYHASVTTADELAREIESLMQSSSQGNDICDRLVDPFGMTPFHILLSAANCKIDLLQVLLDAYPAHVLGWKDVNEKNAVEYFCQRSYHLSEDSQLILQATLQRWLVDSISSWNAGLEAWTLDMANRMNAIVAESELTERQSLLQEASIVLSRYERMEATTLLELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKJ1</accession>
    <name>A0AAD2JKJ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS17211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKJ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11046">
        <property type="entry name" value="CYP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042128800" evidence="9">
        <location>
            <begin position="20"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="696"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="715"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1958508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="728" mass="82290" checksum="8BF95710EB46E239" modified="2024-05-29" version="1">MMISNVWFLVLGSLALSDAFCHHPSIRKASVTQLAVVDLEKTSPAEEMANGNIPKTLRIEGKGIPNRKSKLEMLDATTYESELIKTWETDPDRQSGFDWEIEKLRRLFAGLRMREDGTWVKKSSAFDFLISKQRLQTSDGLKPVNVLDVAILFSMQILSSIGLGPFLGMDPVPTAIIQKYEGSFLSFIKGVLGGDLQTLAGGPLFLLLNKYFLEYGPIFNLAFGPKAFLVISDPVMAKHILRDRTTDQYCKGMLAEILEPIMGKGLIPADPITWRVRRRAIVPAFHKKWLNSMVGLFNARAQILSRDLETKNNQVVDMEERFCSVTLDIIGKAVFNYDFGSVTKESPIVKAVYRVLREAEHRSSSFIPYWNLPYADQWMGGQVEFRRDMTMLDDILADLINDAVATRREASVEELEERENSDDPSLLRFLVDMRGEDLSSSVLRDDLMTMLIAGHETTAAMLTWTLFELSNAEPGMLKEVQKEVRTVLADKESPDYDDIVAMKKLRYALIEGLRLYPEPPVLIRRARTEDCLPQGSSDIRGGIKVLRGSDIFISTWNLHRSPDLWENPEKYDPTRWERPFKNDKIPDWNGYNPDKISGLYPNEQATDFAFLPFGGGSRKCVGDQFAMIEAACTMATLMNRYDFEFEGSPDDVGMQTGATIHTMNGLRMRPRKVSVNDPLPSADGWWEKQHLKRGLSANGRPFESTELLENQHIPTPERPDDPGNRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKZ6</accession>
    <name>A0AAD2JKZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acylphosphatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041931464" description="Acylphosphatase-like domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Acylphosphatase-like" evidence="4">
        <location>
            <begin position="44"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1958832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="136" mass="15380" checksum="D6794B844A9AACA1" modified="2024-05-29" version="1">MKQYIFVLFALLTTAIQGFAPTRQHQQRTVLRATDGEDPNEIVARRITVKGAVQGGYYRSCVNNEAGKFRRLVGTMSPPDESDEAEIYVEGKRKLMAGFIRWCKKGDVGLNQQAKVIDVKEEDPTGLYESFYVKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL34</accession>
    <name>A0AAD2JL34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49306" checksum="01863E25CFC4DAF4" modified="2024-05-29" version="1">MGKPLVLDGSSNCRLVAESIQAAIEDPHIDRLIVSGIDLECEIASSLLVLFKHRIHPWAEIVVRKCIGPIHGLLTLILEESKASVDVLQLDNTVGKLGVSGAIRRGLSKNRDLCKVKEIALTNSRLSAWIMEDLMTGICTHTGIRNLLFIACEFIPSAAAILSRGLKYSPHVQDLSLYGSKIDDYDLASVVDSCYNLTSIDLGHTDCGPKTISRLGFLLDSSRKSSNCKLTSLDINCHRHLGTSTPSGTDLTALFRGLTQNSTVKHLDITSLPLNDKSAECLVTCLHNNVTLESMVLTDCGLSQVSMTLILENLANFAGMRRLYMDGRHNLGLYGRQQWTELATEALSTRNLLLEALYLPPAFDFYRAEMDQLLDRNLAGRRILLSDGMCKTSPTLQNPSAVWSHVLERVNKVALPDGCKRNPPSKAARRADMTYYMLRQRIMLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL44</accession>
    <name>A0AAD2JL44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NAD(P)(+)--arginine ADP-ribosyltransferase</fullName>
            <ecNumber evidence="10">2.4.2.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mono(ADP-ribosyl)transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS17600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19149"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:15087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142554"/>
            <dbReference type="EC" id="2.4.2.31"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Arg-specific ADP-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.31" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106274">
        <property type="term" value="F:NAD+-protein-arginine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.176.10">
        <property type="entry name" value="Toxin ADP-ribosyltransferase, Chain A, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050999">
        <property type="entry name" value="ADP-ribosyltransferase_ARG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000768">
        <property type="entry name" value="ART"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10339">
        <property type="entry name" value="ADP-RIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10339:SF25">
        <property type="entry name" value="SECRETED EXOENZYME S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01129">
        <property type="entry name" value="ART"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51996">
        <property type="entry name" value="TR_MART"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1959178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1636" mass="189168" checksum="74DD06E0289C5EE5" modified="2024-05-29" version="1">MTRRTPVRRSALSVLLDDASSFIHASGSNDDYGSGTETESGQRRSLRVAQRAQPSMGSGWNESGRRYSLRVARKEEPEQQRFLSSGVVGVVSSSWSLRNEGALHLRRERTASEEEVSDSNSIDIGTDIDIDTDWSPSSDLESRRMSNVPLSLELYRARAIYLAKRERRRQVVGQLLVQWKHRECLEQHRLKQSMVLKQVKDQWSQRECREQPKLEQSKELEPVESQWSQRECCEQHGLMQSKVLEQVKNGFNGIELSRKKIDDWLQRPMGRKQFRQLTKAIKMYTGKDYAIINSFLRSGRIQPGKEKYIGITQQARRALNVGLRWEKHLKVFDSDKTLYRGSGSIPMKLEVGGTLCDKGFFSTSQSELKASAFLNTIDRSQTRILFAISRHCSGVDVSEFSKNKHEAEVLFAPDTMFRVIAVDKERMVDGVEGTVTVVEIQEMEQSKVVEKVQSQHECREQHRLKQSKVLGQIKDQWEQRESLEQHRLKQSMVLDQIKDQWKQSECREQPKLEQSKELEPVESQWSQRECCEQHGLMQSKVLEQVKNGFNGIELSRKKIDDWLQRPMGRKQFRQLTKAIKMYTGKDYAIINSFLRSGRIQPGKEKYIGITQQARRALNVGLRWEKHLKVFDSDKTLYRGSGSIPMKLEVGGTLCDKGFFSTSQSELKASAFLNTIDRSQTRILFAISRHCSGVDVSEFSKNKHEAEVLFAPDTMFRVIAVDKERMVDGVEGTVTVVEIQEMEQSKVVEKVQSQHECREQHRLKQSKVLGQIKDQWEQRECLEQHRLKQSMVLKQVKDQWSQRECREQPKLEQSKELEPVESQWSQRECCEQHGLMQSKVLEQVKNGFNGIELSRKKIDDWLQRPMGRKQFRQLTKAIKMYTGKDYAIINSFLRSGRIQPGKEKYIGITQQARRALNVGLRWEKHLKVFDSDKTLYRGSGSIPMKLEVGGTLCDKGFFSTSQSELKASAFLNTIDRSQTRILFAISRHCSGVDVSEFSKNKHEAEVLFAPDTMFRVIAVDKERMVDGVEGTVTVVEIQEMEQSKVVEKVQSQHECREQHRLKQSKVLGQIKDQWEQRESLEQHRLKQSMVLDQIKDQWKQSECREQPKLEQSKELEPVESQWSQRESCEQHGLMQSKVLEQVKNGFNGIELSRKKIDDWLQRPMGRKQFRQLTKAIKMYTGKDYAIINSFLRSGRIQPGKEKYIGITQQARRALNVGLRWEKHLKVFDSDKTLYRGSGSIPMKLEVGGTLCDKGFFSTSQSELKASAFLNTIDRSQTRILFAISRHCSGVDVSEFSKNKHEAEVLFAPDTMFRVIAVDKERMVDGIEGTVTVVEIQEMEQSKVVEKVQSQHECREQHRLKQSKVLGQIKDQWEQRECLEQHRLKQSMVLKQVKDQWSQRECREQPKLEQSKELEPVESPWSQRECCEQHRLMQSKVLEQVKNGFNGIELSRKKIDDWLQRPMGRKQFRQLTKAIKMYTGKDYAIINSFLRSGRIQPGKEKYIGITQQARRALNVGLRWEKHLKVFDSDKTLYRGSGSIPMKLEVGGTLCDKGFFSTSQSELKASAFLNTIDRSQTRILFAISRHCSGVDVSEFSKNKHEAEVLFAPDTMFRVIAVDKERMVDGIEGTVTVVEIQEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL73</accession>
    <name>A0AAD2JL73_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL73"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="287" mass="31783" checksum="7C6C0270A8E5A98A" modified="2024-05-29" version="1">MLDYQQFLKASRETLSNVSVENFGSASFAEAPMNMLKSVVPEGCAPDTDFLKEVFSMNDPENVQQMSVEALKERLASFQAKGWLSQQESRQYKALLNTASGSQNSNALRTLEKQLDQIEEKMTGRSANKTGMGGLFPQTNRFVPTPGGAASSVASDASYSSNSMTQIDNIVSPRILSTVLSESQVADLFVETCFFARLGFIQPPCCMQCTYLEAMEGASPNTRCGRWVVWRKDATKVLHPKSLLANTMAIKCHTTRKLLAGQRVEGFEWDTKLKLLARRPRAAKHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLB5</accession>
    <name>A0AAD2JLB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1961049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLB5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="119"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="243" mass="27079" checksum="FBE24842467D9AC7" modified="2024-05-29" version="1">MSAMEHLAAPAPEVEVAEADRAIPSASFEVAPVTPCEDASVQSVRSVEPAMTVDDPKKLAPPMSKEEASHLSVKALRRSGIEFESKAAVIQGGVKKDIFRKCLPLFFDERDFVSYGEVVRYMFIKNNCILVYTDDTSPFPLYAIQISDVTVEQEDPRKPDKYSFTVSPQPNTNKPAENMLTFILRDKVKRKIAYQVTFDTTNDKSLGKMFMDLFQRNAKKYGDEVITASVVGSNSKIAKNPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLC6</accession>
    <name>A0AAD2JLC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002083">
        <property type="protein sequence ID" value="CAJ1961137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="152"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1961137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="751" mass="86615" checksum="EB66BC0D6041220C" modified="2024-05-29" version="1">MDKHVPYKPPKSGLSPQTTDPNEDTSMLMAQLMATHCYHSDPDASLNEHIQQQISHSFNIAESKYDLVPLEHVAKQQQHLNGKQQNDLYNVIKDFEPLFNGSLVRSGKLGPFKGPKAHLKLTPEAKPFQNRPYSVPKSHEAVFKKTIDEMVQWGILEKCGPMDYLSPTFIVPKKDGRVRFVSDFWQLNKMIKRKVWLLPRIQDILKKRNGYKYFTKLDLSMFFYTFEMDEASKDLCGIVTPFGNYRYTRLPMGVKQSPDIAQAHIEQLLADFEEADVYIDDVGIFSNDWNSHMESLRKILRILQDHGFTCNPLKCEFCVQETDWLGYWLTPTGIKPWKKKIDAILRLEPPKSVSELRSFIGAVTFYRDMLQNVHTFSPLTARIGHNKKKLDWTPECQKAFDHIKAVLSKDAFLAYPAHNQPFHVYCDASDYQLGAAIFQNGKPVAYYSRKLSKAQLNYTVGEKEILSIVETLKEYRTMLYGVKELHVYTDHKNLTFQNLQSQRVLRWRLFLKDFHPIFHYIKGEHNTLADALSRLSMTPPWWQNDNPKDPIDLYCQPIGAYQEYVPLIETTSNVDLSSNDNRTTASNANISSHDTLNSFYSMATDLQLLNCFVHLPVQDSLPFVLDFKSIADAQTQDAELTELTQTKPQQYVQHTFAQDTQVYCYVRDANSPLKIYLPTQLLQPTIQWYHAALSHPGSTRLKDTMRIHFHNPKLSNVIEDFTSKCDTCQRHKAVGRGHGHTAPKEAPLIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLL9</accession>
    <name>A0AAD2JLL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002061">
        <property type="protein sequence ID" value="CAJ1960535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLL9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="158"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="380" mass="43593" checksum="A93CB28FF1F98FD5" modified="2024-05-29" version="1">MEDLMRKKRLSSTSLVIWKTIGAIESGNVLRVLFDSGGLHMMINARAIPKDAKDGVFPEFDKHRRIAGVDGVKANVFDSPTCAEVADKQQHLTEDQRKLLAQALKNTDKIFDGQLGHYKHEKVPLELIENAQPVFSKAYSVPKQHEPAFLKELKHLQEIGVLERTGPSEWASPTFIIPKKDGRVRWISDLRQLNKNIKRKVYPLPLIDDIVARRSGYKYFTKLDLTMMYYSFELDEPSKKLCTINTQYGLYQYNRMAMGLKPAPDFAQYYIEQTLRDLKQKGVEIYIDDVGLFSNSYEEHMALIQEVLQRLQAAGFKINPLKCEWCVQETDFLGHWLTPEGVKPWKKKIDAILKMSAPTNSSQAKECLNGLMNVQKLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLY4</accession>
    <name>A0AAD2JLY4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLY4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="137"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1118" mass="124857" checksum="B8218A2CA5EBB627" modified="2024-05-29" version="1">MIESVHHEVAPPPSSITDENEDLPSTFGDEDALLSLDPESTETLSISRNGTVNTTSSRSSELQSLSSSMKTSELRKPKTTAAIAMRYQQGSSSSGNLDFASMGLIGRETEESTLRSCLANLMVTDSPDSNGSKESGPFKELVFIKGPSGVGKSSVARIVEHDVNQEQRDNSNYNGIFIDGKFEMNTMDEPYSGVSKAFDKICRNIKKGKQESIAEIQQELKDGLGKEVQLLMHLLPELEGLMNDDQNQSTKSSSFDMDAFENGMDQLRYAFRVLARVFGAVFSPMIILLDDLQWADISSLQVLDYLISDTQNSNAMMIIGSYRSEEANENSLLFNKIVAFREKATKFSFRVTEMEIKAFDAATVEKIIATTLAPETAEQGLRLALICIKRTLGNPFFVFEFLKMLHHEGLVSYNSSSKHWTWDMDKIEDATMSTANVVVLLHDRMRKLSNQVQVLLQIAAYCGSSFSEPTLDTVWDHHGRRLVGSKIEKISELLPRLVQDDFLEPFGEKHYRWVHDKVQEAALCLTGKHRESLQLDIGTTLYYCLEDEYLEEDLFNVVDLINRGNINKRSQFALANIRAAKKARSISAFESAAKYAAHGIELLDDSTKWTENRLLALQLYTIGAEMNLLAGSITVADQYCDVVLGRSELSTMETLPLKMVRAKCLSMMELKFNESVEYCLKLLREMGCKLTWPRFLLPVQGLTMVLRTIRKMEKVPEGSFESMVVIKDKRQKAIASLLSMIVYMSYHSGNIPLLFVGICKLVEMTLEQGINEFSAKSIASMGNVMLLLNKDPAKAVEYIKIALSMLAKFGRMRSGETTYLAYAHGLAWFQPLESCSAPLIDGYKKALRAGETEFACWNLLSYVAMVPYVLGKPLAQILQECPKAMIQFEEAASEIHVLDMRVLMQMLSNLSDPSCPDPSKLEGDIFSKANDEEEAKVHLAISHYAEGELVLFHGDYVAAADRAIVLGEVHTELVPGTYTIMIETFHRAVALYAAALKTKKEKYKVHAKKVRTKISSWAKAGNPNVEYFDLFLTAEQLALDKKLDEAQLKYEAAINAATGAGHLHHAGLLNERYADFLLDLCSNVEESKKTLTTAIKWYKDWGAAGKVKALESKLGEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JML8</accession>
    <name>A0AAD2JML8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JML8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042288698" evidence="3">
        <location>
            <begin position="24"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="619" mass="68769" checksum="A7CF981EDE88EECE" modified="2024-05-29" version="1">MKFQTFVYCSPLCLLAMAMESNAFSGYVTSRNQYFPSGATVGTAPRGSSRSALALQAAHVSFSGTATSKYPLFVASSDGMNPRQERPSLRQKLQTALLLLSHWVSQLARKVRLPLAVLMSAWMLNFGGLSPLPAHAARATATPTKAAPSRPQKRPKQQQKASETEKSTSSSKDRNMKRAVIALGFGASLYSVTTNRKRGFGQAQQTDGEAPPMKVVEKLTLEDLEDLEHLEHEKTMEVLTTDVEIEESIAITSEAEFPLTSNDDDDVDDDEIVAKKKKEEDNPIIEFLDAVGANPEVVYGFLGSSLSFMASENLLISGITFAWIFKLFKESEASDFTDDDNGDQDDEEGVTAEIEADDEEEVIAKIEEETEEVIAEIKEEKVEETVIETEAVVEENKSHVVLEDYRPEELMAEASSIAEESPQVPEEIPTEITEEVVAETSTKIEEIEVTNDSSDEAEEEKEEEVIPNQETIEEVVAEEASEPLVHEEEEEEVISDQIEIEEVVAEETTEPIVKEEEEEEEIIANQATTIEEAVAEETAEPIVIEEEEEIIPDQIEIEEIVAEMTTEPIVLGKEEETIPNQEEIEDSVPEAKMSLGDRAYKVVVDLGLIEWDIKKREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN17</accession>
    <name>A0AAD2JN17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS21715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="108"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1966132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="562" mass="62728" checksum="A614BC99A76EF8AE" modified="2024-05-29" version="1">MASSSLSSQSAAHETDSLLETPQTDNLLRNSSNQRRNPYGIILSAFLLAMMALVALFFFNILPYKPPNTDIVGSQLLQLSLHMQGRVVFPEDADFGDASKVWREDVVANNPPLAIIEAFSESDVQLAMPVLARLFRLHDIPFRIRSGGHNKAGFSTTGGGIILSLKQMRNVELLKNNDYDSNELQGDILTPHPTTKTVVASVQPGATVEVVLDNLLEQEGAGGTVGICGNVAEGGFVLGGGIGFMSRSLGLGIDNVLSFRIVLYDGTIVTANAESHPDLFFALRGAGSGNYGVVTEMEYKYFHPMPREQRSRMVIIPIEDFASFLYNLGKSPPSREFMSIFGVSPDSATALMSWFSADPERIDESEDRFQEEIAPLLPASSYEQVPYAYFDWADGTHDFSDKPGYTDHLYAVQVWQGFLMPANNTRAVWDEIVSLIQHIVEECPDVHPDIELWGGAISDTPHNETAFAYRDALFNVGVQLYVTKEAYKEQFEYELNKVNQWWPSVAQYLEGAYVNYPMNSLGDDEYPRLYWGNHLERLVHVKRQYDPLNIFRYEQSMPVAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPJ6</accession>
    <name>A0AAD2JPJ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPJ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="518" mass="56641" checksum="1D50D2E5D84E655F" modified="2024-05-29" version="1">MPPPPPPPPPPPKLGSVPAGNNHPLAAQSVATPGVSSMSIPKPDAPGGLAAPTSPPLRSPVPIRSASPQVKVTSAAVSPARTLDAQADAFLSAPSYRTNQLGLEPALRPLPLPPGEGIERVRTLVERRAWGDVLKLSANVLQSGNPHADVYSSLLLLPTMAPKSDVETLPLAMKLETVEVMALYCHALLKLRRYADLEKEVAKWNFLFQNETNVFSPDWLPWSIHILGAQSLQYTGDFDQAADVLQDLQSRIPQEDASALASVNIALANLYIRQEQWRLALGTLDRITDLIPAATELEIQSKYSTAPNPAALQSTLTAAYQCEVRFRQGKALLQIGALPQVAELFEYARNEWTAANANIPPELASHPAVGLMFCQMEVNEGLFYFAQNDYDHALSSFSNAVDILRRMDLLTHKYNPDAYLGTGVVCLDEPNELYSECVNNLALCNLYTCKMQDAVGQLEDLVRSDPTAFLTERVAFNLCTLYELGADSAVSARRKRVLQLIAKRFFLHDIGPESFRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV17</accession>
    <name>A0AAD2PV17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS13998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="32"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1953374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="32827" checksum="69850CEB607FDC78" modified="2024-05-29" version="1">MSNYNSDSQSSSSGTSMPDLVAEGSTRKEKEARLHFPCKVYDMLEDADQQGHKDIVSWNASGTGFTVHNKDLFTKTIIPQYFNQTKYKSFQRQLSLYGFQRITGGENKGLRYHEKLRRGMRDLCRSMKPIGYKPRSSEAKEVMKALSSPSPLRAMDDALPAVISSNSLPESDGIEKAALIQTLHAPVEFTADGFPEMGCFEGKTFYLMDSRSFAHLTKTTTTTAATTTAATQPVAPTRPLHNADTRPVMIDGQMKRAWEIGFEMAMAMKTGQNSNHNLEHAGIDLSSHQQPLYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV40</accession>
    <name>A0AAD2PV40_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="208" mass="23064" checksum="47CBC20378EFA389" modified="2024-05-29" version="1">MTSHINVIYQNNATVALLRDQDASHAIVASSEALRCLRRCASTLHDVPANKSCTDSLLDQCMARSVTDQSQAESGKPFIFDRGIQIPLTTTDTAAISAILIFNSALSHQLWAAQNPADAPGYLTKARQLYELAYRMDDVEHNVMFQIAIMNNMVVIERSFGNNAESERDFGHLLSMWMLLLDLGYGSRIHSMRGFLVNGRWSENAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVA6</accession>
    <name>A0AAD2PVA6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS15080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF35">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="139"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1954487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="262" mass="29334" checksum="5AF10B9075D126CA" modified="2024-05-29" version="1">MIQSLSPILNSGLLNDHTGVLAFNAMQTFLIAAQFKGESETPTPYSKFAQGLPKDEKKRVSSRNGMLLIYVPASMVGLLFVLSSSAYSTPAALMCFIHFLKRDLEVLFLHKYSGTVELGVSQFIGFFYAFITFMICLVSRSEVDPQVLQLGQALFSIGILGNFYHHYLLASLRKNGSAVETKKYHAPTGGLFEFVAAPHYLFEVIGWLGIAFVSGDMTAFLNFGTMTAYLSARSKNQNDWNRKKFDEKEWPSSRKNLVPFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVH8</accession>
    <name>A0AAD2PVH8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVH8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="184" mass="20821" checksum="D85893895F55CF2C" modified="2024-05-29" version="1">MTIVATEDTRNVEWRKSNVGLKLLEKMGYKDGEGIGKRNQNNTALRALKRKEGLGLGAKIQSEGGNSESANHFSTVLSNLQEHHEPTTKKSRKKRKGITLPQNKVTAGHASKMREAKFGAKSAEDMACIFGNTDFPVLTAQTDVSEKKKKRKSKKRERDEDDENQKQKRKDKKKKRKEEKKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVX9</accession>
    <name>A0AAD2PVX9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001966">
        <property type="protein sequence ID" value="CAJ1958073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVX9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="139" mass="15450" checksum="97B2E86F65E23882" modified="2024-05-29" version="1">MADLFCPDPYFDDPPILTAFDVNQSSRRPSVLFAPEAPIDFDIETGPLLAKDSFQDLAPDSPTKPAKPKGTSTINVPSALQRNPRQKTRYSTGNRNEERTDHGPTPQTEQKHDPLPPTATEYKNPSSAVKSCGRDWERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWF3</accession>
    <name>A0AAD2PWF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS18508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="292"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="292"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="348"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="398"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="398"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1960093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="504" mass="57411" checksum="9A6767152E59BB01" modified="2024-05-29" version="1">MFTLREDGTFGTGLGINLDVRVDSKPSFDVFDALDNSIQDSFPTTFEDVDEYRDVQQQPSRSFDDELRIGATLEHHDEFFSEEEQHLPDDISLDTLEEFGSIPFCPVEEPRVPKAFGSEEPFFGLNDPQETVTPEVAATIDDIINEAFSGFCSPPHSPVEEATGYNDVLPFHNIDEETNVNHQMMMQESYAPVASISTAAVPSSTTRTVSPSLYYSGEDYRAEWAQRIPEIDFFAQAIRQPGGLREIPIENRDLLGGQNYIVKTPLGLAVLLNCEDDPNRANAQQPSSNVLGRRRKFQRWLEEEDEILKQAIEAEGSPKVNWKRIASKYFSNQRTALQCKSRWTKSVKPGVVRGPWTKEEDACILRLQQDGLKWPEIAEYLPGRLSENISERFSNVLDPSLKKSPWTREEDQILFQEQCRIGNKWTQISQLIPGRSESSVKNRWHNLKMARKRRMRMGSTMKTCQRVTGGHFFHHQPMQEPMQEFGVVPATVQSQSTPSPFQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWP7</accession>
    <name>A0AAD2PWP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1962090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1433"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="844"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1442"/>
            <end position="1461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1540" mass="168626" checksum="8F17536DE9899642" modified="2024-05-29" version="1">MSEASSNPSGKPLFDIMCILNVEHTSYNIGTYQTPSNQSHADPANHNNNNIIANNSHRNDSNNNNNNNDNNKHDPNEGSNGDTTTNIDNDNSNDMTRSNNTTIINNGNGAMQSNPLRSLSQADHNRMSATTNAITTTTTPIIGNPLEAATDTDTDTDTSSQTNGNRNQQHHHHHQNGVMESSSSVANTTTTEPSSHPNNNKNKHNNNNNNTTNASQDVPVPNPLLDGTTTKSSMGTGQQQEEDGDDDVDVDDDCSIMEVDSPATIKPSTTVPNGRDDGKESSSSPPLPSHSLFQTRTTTTANKSSYTGNEELKKPPPPPSHSHSLFQTSTTTTANKSSYTGNEELKKPPPPPSHSLFQTSTTTTANKSSYTGNEELKKSPPSPSPPSPSYLDPMELSSISTVTFTHALFGRANKSNTKQEEGEKQSATLTTTTTTPTTTTTMSSLEQDDKQKLDKVETTKNNNDNIDNNDNVQILTKKHAEKEWRRKRKRQLRKQLAGNKGVIPSFVSILEGPIHIDEEKEKEDEEMKEDVTITKIVVNVDEYLKLGDMRKMVPNNVKSYNRFSVTAARSKSIAVGGPSIPVPSSILSASPVTSGSIPLDPDPKDEGYYEGIKHMAMPEDEIYLSDMQQWLRQNLEFFSATQMDAQMSQSGRRQRTTRGKVGIRCVHCARALLPKFESKLNTNAMKYEQWPPGSVSYPATMDGLYSSCSQRPQLHFKTCPYISAAMRIQGSQWLSGEGESASAHPTKRRKRCREGISAVMYYHIACERIGLLETAGGLRFTRDLNLEPLPLEQARHKVEVTKPELTIKPRQRQVSYQPMSATSSVSSNMPPPAQVKAEKTPCTNEECQQILQEALQEEDDLSVRLACKEDNEMVSDYTFLAIKQMALCHASPLDFVSRGKKTKLMRLGFSGFCCRHCNDKNIATHACRSYSSAPDNLASAISNSFVLHLAKCPNTPTKIKQALAALKKIHSKQMQQLPYGSQRKCFFELWRRMRAADKIVEGQENPTVEQIAEASEEAGIAMSAAAMPDSARSTSVETAIESNRKNSRSAGFPISSNENSLRVLKKAEEEWDPTKDNDNLMDKDDRFLVSDYVFLTMRQLGTALPTSADFRGNRRQNISQRMAGMKCLHCLEEHGFVGSGRSFPSAPDNMASAFNTSLYNHMQACPGVPAELKSAFSDLRKIHSMQCQNLVFGSQRKFFNKVFAKLRRVPIPQSVLEALPPVPSPAKKSSYGASYGATVPMASDEALQKHSFVNGPALDGFPAFYQCLRCRAVPFAFRAPGCVQNSRPSTSLLVKHTMACQGDAIFMGFVKAGFNALTEDFEFLSQLKPFQDLVHHVVGGDDELAALFSDPVEATKKTTTGWWRRLPASVNFDEAQKRFEKMASDLSISSSRLQDQPKLIRYLQTISPNFHIPSPSIKDETKDVSMEVDEQRLTGREGASLTDESAATLSTSPAGNTSVRQSTTAANSVMASAAASPPRAVVATGITSSAKSTAVPLVDVKPDGVSSTSQCNGGVAIATAADGQKEIVIDDGSDDDGVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX41</accession>
    <name>A0AAD2PX41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS20693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="537"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="803"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1964566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1170" mass="132114" checksum="FC4CBF3503F7D5E8" modified="2024-05-29" version="1">MPESKPPIRSIIQEEPPDTGLDKRDGLETASINDNESVQRREEDSELGSGGNYQFEQQEERVGSTYVVVAVVVLATLVFSAATTLLVSSNQQKFRSEFESFTREFNENALNNLDTIVGQLTTLAVAITFENVDLGTAPNITIQNLDQRAQGMADFSGIDMILYAPIIERSQKSGWQKYAAISSQEWIEQDFKYRGWNLSSVDPIADEVFSSDFEFDTDITSEEKREIEATDVYIDQALANSGYSSGSINIPISQFGPGLVNSSIIMMDLLSHPTLGKDLSISLQYTEPVLSEPIDLSFLIDHILSPTNYTNETKQSYIVYPVREGLRDDADIMGFLVGIVSWERLLNLEIPSTVNGIYTVVKSNCGTEFTYIRNGGKPSFFESGDTHDTQFDLNKVSYPFFEKQAGDNGEAGAEFCQFDLNIYPSNEFRDSFDPLDPSIYAGLMVFAFIFFGAIFFLYDRYTQKRRKELYEQARRAEAIVTSVFPEGVGLRLLQQSQREATNPQSSKKMLNSFLSKNEIAEENLRRKPIADLFPSTTVMFGDMVGFTAWSSTREPSQVFILLETIYKEFDRLAKKREVFKVETVGDCYVAVCGLPEPRKDHMTRMALFASDCLTSMSVQVQNLEEELGPETADLGIRIGLHSGPVTAGVLRGDRARFQLFGDTVNTCARIETTGNRNKIHMSKDTADLLTKAGKSNWIMPRSDKVYAKGKGEMQTFWMKHLTTEDGVSVGDGKQRSDNVLPSSFSHSKRRVALDGTIKRKPQDLTQRKFDRLVNWNVDVLITLLKQVVERRQSVGAEPAELSTIQEVEKELSVPVSEGGTPAFDQVVESLELATFDAKAARSQLGVELSEEVKNELKEYVRTVASLYNANPFHNFEHASHVTMSVMKLLSRIVAPDIEGDESQLHDHTYGITSDPLTQFAVVLSALLHDLDHLGVPNPQLVKEVPELARLYKDKSVAEQNSIDLAWALLMEGKFATLRGSIYSTTSELKRFHQLLVNTILATDIMDKDLKALRNAKWEKAFSQDMVGREREALIEINNRKATVVIEHLIQASDIAHTMQHWQVYRKWNQRLFMEMYRAYQEGHADNDPSEGWYKGEIGFFDFYIIPLAKKLDECGVFGVSSHEYLNYAQQNRREWEKKGKSVVAEYMKEIQHDEAAYPSGNFYLEEEKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PX72</accession>
    <name>A0AAD2PX72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS20727</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PX72"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041942323" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="11">
        <location>
            <begin position="19"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="749"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="785"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="813"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="646"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="891"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="922"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1964634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="935" mass="102593" checksum="D228795CCC0C00A9" modified="2024-05-29" version="1">MKLILLGLLLGTLPATLAQQHNFTYSELQPCPMGSFELATQGPKDVVKPCILYDVQPPNVSNSNATSSNNNSHGNTTTIAIVQVTPSSCSNHRDGAVIRVQKMNAENNGKGWVIGFNSDHYLQFRLVSVVAGNDRNLTEATYQEQHQSILGSMISTLNAPYIIGSCSGVSNLEKSVALEKKAILMAQVGPPGFYTDRNPYVFGFHINSDIYPLANVQALQFLADARNQDPSQFPVSVISRTKSEFFQSTCRSAISSLQSSGFSNLTEYFYDHAADEDGDGDINQFDEDYLQGLADAACPPGSGDIEGFHPALFLCTLTEQDILIPRLMENGCSPTSIWLTAATWTWATNNPDVVPYYQGGGQWHPAFDYADSYFESGQALLESNQKVYGYAGSYDQVVSYAIPAVFAEHLVSHYQLVDVPDPMADLQNEEAREFLRRELTVLNTDTLFGPVRFNRFQRNNGRDAAATQWQPLNDDRSFRNGLVSPLLQAEAQTVIPSLNALECEAGSFVNNSLIEAQGALLLNTCSGCPLDTFTKSPSRSKQCEVCPEDSTTVGLDTNEYCVYREDNLLPTWMLALAYILVTISWCLSLFFAIWLFRNRKDAVVRVGQIEFLLLLCFGAILSSATVVALSMQAGTGEDTRFASTGCALAPFFYAIGWVLQYGCLSAKTYRLYQVMQNANRIKRKTTGAMWQILFACMLVDIIIMICWGAINPLEYQRTDGTSSVDEITATVTISSVGRCVGSNPDSSPWYFAGPLLAFHVALMVSTNILLYKVKGISDRYQEGKYVGLASVLMFEILIVGIPVFIAVSDNSVAVFVVLTGFITLADISILCCIFVPKIMFSKKGLNEGISVGESILKKSLKKAETRESMHRTFSQAPSRFSSASKVSFASEIMPNSSGHSERGRITQEPAENPSESFVKHTMPSQSSSANGDCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXA8</accession>
    <name>A0AAD2PXA8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI transamidase component PIG-T</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="62809" checksum="B9ECBFDC0548B58E" modified="2024-05-29" version="1">MSDHQEPNESFGYEEQVLVESYGGVTALRLEASSRWNPNTKFHPFGHLNKLFEVADKIIGVADDLNSPGQDDEDHQPFLEMIMQISSRATQDLPSSNKKRLGLVATMDGSLPTGPSGFIIQIRSSLPPSPSLTTKIEAMVQSWMNERLITTPILNASWDVVAERGGGKNDSDSQKPPTTLVQVFLPTNGAAWSADALQQSFRASLGCEQQSQFMGISATTWSNQLVTGAAWNKQLWWKVSSKEKTRRVTVGLQLEQETKNAESLLSLMESSKTSCLLGNRSIQHVHPASSSISPLQSYKLGASKALESSTIDPLASVDMVLRRTYPQKGRLETWITASSNNIASSECSLQFRQVIPPYLTPSWQTLEVLTSKEDTPKIQPYVEWIENGASVVTFSLASISESSFTVMSLEYGPKFVPYDDIPGDPNRGRELPPAVVHIQCPLKSFDLYSNSPLMLPPVPDMSMPFNVLSLSCSLYAYLIGTIISLLVKRASEKVTYKLHPEKKPKSKLEKLKEKIKSKLNKLKGEKNHQETDSKEDGDRDTNGNNESNENKQNESLLPENKTNKGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXK0</accession>
    <name>A0AAD2PXK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXK0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF652">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042241001" description="Amino acid transporter transmembrane domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="75"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="482" mass="49814" checksum="239AB0629697D646" modified="2024-05-29" version="1">MQLSKATLLAVCLAAPTSAFAPSASNGLLRDAPTALPSSPMMSSSRSSRHQSMVAPSLMAAAVDDAAEESIPEGTATVTELIFNLVKGIVGAGVLSLPAGIAAWANAPSAVVPAVALIAGIGGLSGYGFALIGRCCAYTNSKSYREAWGKTVNESTSWLPAVAVTFKTLSAILAYSMILGDTFVSLLTTAGFSVAKTPVLLALTSTVLLPLCLLKNLSALAPFSLVGSLGMMYTAVAMVMRYATKAYTKTGRFGTDCAAALRPAFGSVGAEGIMTPSAAILVGMLSTAYMAHFNAPKFYNELKDKTLPKYYKVVGTSFGISISIFALIAAIGFLTFGSAASGLILNNYSTKDSLMSLSRIAVAISLVFSYPLAFVGARDGVSDLLKLKSTPKTQNVVTLAILSAVTFAALNIADVSFVLALAGATLGNALIYIFPAFMFRGAIRDKPDATPGQKREVKFAMGSAVLGLLMGTLGVKMTLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXQ2</accession>
    <name>A0AAD2PXQ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002318">
        <property type="protein sequence ID" value="CAJ1967266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXQ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="129" mass="15187" checksum="CCC5C99E8E985150" modified="2024-05-29" version="1">MLYGYTLVLFSWNHIILVKPFACVYQFLHTTRNFTQDNEPSHFKTEPWHEEAVEASCAEQLHRKTQQSNFVGFAEDLTVGQEIRLYLFWALNAYNSRLNEFAQAHFRLFSMVEKKLYCGAFASCFSNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAG3</accession>
    <name>A0AAD2CAG3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1903008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAG3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1903008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="437" mass="49360" checksum="9E283DE10996BF99" modified="2024-05-29" version="1">MMSSSSRLIVSTVWNHHRAAKAPSSSLVRLFSSKNNQSNDDSSSLFDSAGGYFNSLRWKAANALTASLPEAERNQLLERMEPKKESQNSQSSEREGPTVPERSIDEIIAATKAEEAAKYEKRWVNTKEQLQKEAEEAALKRAENDIALQKRKLAFEAWQKNLEREMESASAAATTPTNVTSVKEEVLARLGDHPILGPVLVDLGSKRLHLVTAEALAAVPVWKKQRTYRHQRAKEMANDKMTTLHLGLPGIVGIYESSDGNLSIIDGQHRIGMLRELKNRNPEGFDFEQILVEVYPQQEGMDETEHAQEFFSEVNKAQPVRLLDLPNMAKASHLKMINGAAKTIKEKYPDMFSESQRCRPPHLNEDNLRDAIFAASVIDRHSLKSPKQLQDWIMTQNEIMQAKLQEEEAQQKVNAKALEKATKFGFYLGLGNDWYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAT4</accession>
    <name>A0AAD2CAT4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS61</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1891051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAT4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1891051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="493" mass="56385" checksum="E2A2A97EBAB2E310" modified="2024-05-29" version="1">MSAEASRPRQSEPVTDKYGLKSSIAAVREILQKNAAAIAESDVVDELSKQKQASYQEKLHLQEELQNQRALLKDLSSKTEHAKAEALREKSMRLILEEAYSKLEDHRKEILSQLDTTKSSQAGMEEKIVRLHEDLDKQNTEFEKERAKWEELMKAMREQDEASKREIGRLDARLAASQQEVKDTASTIEDLQKQVEFAESRHTETVHGYKDIIDKLNSRIEKGRFETIEDLQKRLEEAESNYETTAKELQSTREDLLSFRQFSDKRQETVLSQKAGEKVYEELESAEASLKEAERELESNKETVATLEKEDNDDYKKKDKDDSDKTGEEKDNDVSKKKDKDDNSDKKDNDDSDKKDKDDNSDKKDNDDSDQTPEERAAAAKSQRTVELAKAKLNVKKCTLKLRQTLKKLDGLYKRRLELVKSEVSGTKEDLNTVMARLRSVGADATKAQSDYANFQSRKAQMLQDKDASNKKRAAADDKGEESTTADKRQKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCK0</accession>
    <name>A0AAD2CCK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component Sec3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1897906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 C-terminal" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1897906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1312" mass="146434" checksum="4CBFBC46606906CD" modified="2024-05-29" version="1">MDGGLVKDVFKGATKGVKGVGKGVTKVASSTTKGVTKGVTQTTLLAAKGVSNTAKFATSGAVQGVTTIGGVGLKATKGALKVTGVNKVYKTVTGATPKIKKIRDGDDEYIEEEYIEQNEFFANMDEASALKASHILSSAGTHRLNRILRKTNDDDENFNVTGLNDTNTKKIHKVSDPRNFAEVSEFVAKVVLPPLRVDSRSIGGSSFTEYPDNMTVETLLTFKCRSFEFTGDAHISVSCLQNPAGYAKHKRSLGMMGKGTKGRNKVHYVVFARSTNRPLINSHLTKTEVKSDMRESNIDSGYDKMFSPGDEEPFDEEKEENMSIKDDDDNQDGAGGEANRAGQDDLDSEISSFPVMLCMTLNTDGANPDIRKLVELDQLTTVQDVTATVVQLTFQNGHTIRYDFSEEDEDKAVEAGLIKERFIWSLLQVHAMLCVSVVERSTMGDPEAKERNILPPLNIRNLDRAELQYIATVNNFLRSSKSLAALLDRQQELARGEKDGGQGQMIENGEEEKADEGRDVMAYDLMMGNFATRVAIFQSADERAEAEEVLNSTEWTLSLNSEESAAATAAERLSLVLQRRMRDLEAETCRRLIAWEDEKHYSMTGHVGPNSSRDTVDALSLQHLFTTLESLDAELAEMEGWLDERVLAIKPLTDDCRDIEEENRQLEQQWKSYDLLGSEMKRLLQGLTIQEDLEMILSNPAGALVYDDGGNIQVAESEGGVDRIYEAGKALQQATEHAEKAGGVHLRAVSERVEKLSKTGDFFCTSLAQIIVTIMEQFKTMVVAGSDYGKVSKSDTHSMIAKKVRDTQRKFQSSLLGYIKLIEVLALLDPKLLPAIRDAYSEMVSEGILMKKRMKGYFQALPGKNAAYLNNAAKDLVEYSPDDSPFSHMTVNAEDIKFSMSELLPVVAREAYFTAALFGLSNKAKDGREKKRNFEAAKKSVDHSTQYFRYYIQRTCGIADETEKDPAQRIRGDPMLSLVASIHLNEAMENYIDREKKGGDHSLSLAYVRATILDLRKKVDKQWVAWVENQIEWIRSNPGVPINGKRAGVFASFSRFPCYLDHILLCCREGRKDNFTPDLAKIKVVSYYLQKMASALLESLRDCAEREATDQQYAASVMQMENSYYFTQSIKNRGSEIAVLFQKQVTKANTVCKSSTDAYLGWMIKREFKSLHALFSNISKVRREVGDRDVPIHVPKATFIRTLAKESNREVMKEKIAVIYSRMEKHLSEEGGLLPVAWKALVKVLYEWFGRWEKLSSQIYKHVLEPSAVDVVRIAKAAGASSAKADDRKVRSEAESRARLENRRADRTRAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CED3</accession>
    <name>A0AAD2CED3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000201">
        <property type="protein sequence ID" value="CAJ1932027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CED3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1932027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="227" mass="25574" checksum="9B1C798F5AB7C3B6" modified="2024-05-29" version="1" fragment="single">MTLMSDQSGESIVPEVAKALKWWPNGVRLTGGTFRPDKSFWYLIDFKWNAQQGVWKFRRKGDFKASLLPTGTSAIAVELDDLDGTPVHLQWLEPDKLAKTLGIPMSPCSNRKAQLVVMQGKAKAWADQIQPSFLHRYDVLPLLCITIQKTLEYPMALNFFSPQEWNKILSSVLRAALPEAGICRHFPRAMVYAPIALQGVGVPHPYGLQVIKHLDMLLRHPANQTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEE3</accession>
    <name>A0AAD2CEE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS2445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000158">
        <property type="protein sequence ID" value="CAJ1931562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="795"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1931562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1357" mass="153324" checksum="64D6EE2C0720A0CB" modified="2024-05-29" version="1">MTSNPYQCKDCGDEFRRVNALIQHQNNSSWCPGAIDRHNGRRQQRQQLNQNPINPSEYVCQQVYNPPVLPSEIEFQSDEPKSSLQEAPHTREKRKWSSSLAAAACRSSKRRRSVRSPVPVPEPPPPIAARDVDDVNFDPELTDFAGEMERLHLGQPFPPNLLIECNSTCPPLENSSLAVHAPLPLPNASNRKDYPRTTTTTIMGCKLNSEIGKVYNFPMEEQQRQFSNQFLPADKVLAKIHFECYQAGSPLYLPDRIIGILQEANWTYAGFHLGSPYITKRESLLKRIEKTVGASPPTVLDVNLESGLRTRIHRFDFQARLQDHLMSNVFADYGNLSIRTPQDKDVSPFINTMDGALEEPPTIPDFVSGEWYKKALEMYKLDLDSGDYLLHPLVAYMDKTGIDRIEKNGLEPFAVTSANLSQGSREIAENWILLGYVPSLKWLKHQHSPTTTTNKRSLALRDYHHCLSLLLEPLKTLQTHRPQMLFRRGAFCGSFRIIPPLASMIGDNLSNDMLAQRVADQSETSPRMSRRCLCPAVEADKPLHKCIPLIAQFVDKLSQGSLGPSYGRQYYSFVAQASQFQNVIPESPNFEGWRKYVDSHAAKKDRTLLVRTKQRRMLICDLILHKVLGCHSLLNAFNGIDFGPTENGILEATSTDPMHTIEEGLIPMILEVLFGPMTESSLTKIDCYVQSLFGINKNRSRERENYPRVTFRQGYTKLTNLSSSERLGQFFLLSIILQTEVGQGLLKERFDPKFDAERRRRQARSMSKNIISGASTTHPTTPPPVVTETTLEYADSPDSDSDDDGDGEEHDINTEEDSGNYPDEPETSETLEWVQIKEYLDFVGLTYVHKDLDPLLPSHHQRILRRVLKERIKPVWKEHAEPHKNGRLPDIDYTPTLIDCNLHNMKDNCKPWHPSADRVNKLWKPSVANNPRNIPGSQRSIALTMPEFTYLVESILTFHSFLKNPPHLGAQNNSEASRICELYSFSLSMMLRVLVHGVNRGEGTKGWKIRKFVELSHFLEDLIRFGSSDGFNSSTGERNLKIWAKLPSLTAQNRSAIIHCKQICDRVYEASLLGHVSSFFQSPNKKILECQASCLGDWIPSSSEKFTLCTKTGMFTKLLGSKTQAVATPPLSAAAVDWFMKKFENRPRLIPIYTEAKIFDEVCRAHDNYRQGGAWNDYVHAQVRESPSLAGSSEDIGSPCRLGAIWFDKEASDKEASGSSPCGLEPSLGTMRCLLQVGSQRDPTCTARDNHSLLFSHWKMEQEVVSMGSSCFHQAVFQSFPLDIIDHRIYCVDLGAHLQGNAFTRKGNLTSPTSFDIIWTAIDDWPGLFLESPSFLKVMSQTSPDYGRGRARRESAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CG20</accession>
    <name>A0AAD2CG20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000280">
        <property type="protein sequence ID" value="CAJ1933583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CG20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042034101" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="272"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1933583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="599" mass="67118" checksum="BE79A1D04A4765A4" modified="2024-05-29" version="1">MLRWNKQGSIWLALVAILVNFISSHTCSAIQCNVFLAESTIPNAGLGIFSGVELNPGDPVGNGDVCIPIFNVEKHHEEPSDAINDYVWAGEVMGMKLEAAPDLIEANCLGLDSALNCNLALINVARAKPKYDDAGLHRSHDPAAGSITPYHNGTTRATIKVPIGGELFKHYGDEWFKGRPDLFGESFPLTEDFASAEEIINDAFSFGEETARSILEEVIFPMQRIWGSRVMNAIPKTIDEASIAFREGIEMVYQPNATRSINWLQEHGKCVDHIIPKQSTIEGAGRGAFAKRGLPKGTIITGSPLHHIPMKDNFIPIFRTLRTDANSDEAPRREIAGQQLLLNYCFGHSESTLLLCPYGAGIGYINHNQTRTNVKVVWPDDGLMSHDETWLRKQPEEMIEFSGAHLALDYVATRDIAAGEELFLDYGDDWEEAWNGHATNWKSERIWSSSYASAKRWNEKVDGIPLRTAEETSTDPYPANLHVRCHSELDEDDWGSFEEWPASEYGYPCEIKERKKDTKGQDIYSVRLVTEKYDRWDTEFESPQVLDIDGVPRSAIRFFDAPFTTDLHLRGAFRLPIGIPEAIMPAEWKNVPFSVYSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHB1</accession>
    <name>A0AAD2CHB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1932830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="461" mass="52089" checksum="D57A9F0CB38F4972" modified="2024-05-29" version="1">MKTRVPRDQPTRQNLFLFLLVSLLFFWIIAEHKFTNSKFLLALTNLPTYTNPANDIVFHNAINSSEASGNSDRTISNDCLVHTSLNVSAGWKIDGGILEQETATCGKLRRKWEHNPPESPLAKQMANHQSDCSKPIATHYLDNTYGLGSHLILWGQAMCNAMEQGYRLHSSIKVDSEYKQWIWLDQEYCATQDEHPMTCYFPWAEEEACALANQDSTGNIKFSYNFTNVTVQDPRAYRCALTQKTVGITERDEYRASATEYLFSHVSPLVIQEAQRQIGIIFGDLPNAMAPENLITVHIRWGDKFWEMDLAKIEEYIDAIQSLIQSDASLVGPDGLVHIYLATEDPKAHDEFLAAVPNDWKVYADITLQEINSFRPVKGNRASHATRNTKGRAGLVAMGSLLVALEAKAYVLTTKSNFSSLINHLRRKIVNRQCRKSEGRINDDDNGDECTAAIDLRPDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK99</accession>
    <name>A0AAD2CK99_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="169" mass="19007" checksum="BC8CBBD722C30E45" modified="2024-05-29" version="1">MARRQKAKRAAAAAAEAKIKNDVEAINMTEGKAKRRMSSKSRAAHKGNNNAKEEPKKERDEKKKKASGIDPEIFPPNQEDASSCEWTQAPSDPSSAEEEDEAMEAHEEHMRRRALREVHSNQPMRLSRRSSYRISRGRVDTPVYSPIYATQLKLTPDADASCLQDDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKA9</accession>
    <name>A0AAD2CKA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS5413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000569">
        <property type="protein sequence ID" value="CAJ1936887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKA9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1936887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="166" mass="19191" checksum="F4D12EC57EAFADF7" modified="2024-05-29" version="1">MVHDMSYNTVSNVIATWEKVRQVKDYEHVVGTQLFQKFFASTPNAMTVFGFPKGSDPSSKDSLENPRFVKKAKWFIRVFIQMIERSLDMLGPDSELLTEILLELGQRHVRYGVDTSYYPAMGKVLLVVLDDVLDEKTFTPQVRKDWEEVYTALYTDMIEGHNMVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLU9</accession>
    <name>A0AAD2CLU9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000713">
        <property type="protein sequence ID" value="CAJ1938411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="263" mass="30088" checksum="696764D7E2962491" modified="2024-05-29" version="1">MEGVKRSVKMVRLGKRTGKKDQNVTVYGLARDPLDIKCKEPNLLSCSYEDEMTEWRASKESAASAKGEESRYGGEYNEDLSHSPVRLENVLKHSLRLYKYIEEQKAVDKEEYQRKFKITMANLCDKSAHVSTRQNQEYAAQVTNAFGMNHRRLAQEKQQGVDITPYVAGRIVFAKCLKGKNMNAMVLEAVARELLSETDKAAYDEGKTISINYSTLRNLIADDVVSRWKKEHIDEPLSEEKQKVVRKTFQPISEATFVQKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM07</accession>
    <name>A0AAD2CM07_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS6403</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042168151" description="peptidylprolyl isomerase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1939057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="210" mass="22479" checksum="83B4B1023ECDB8E0" modified="2024-05-29" version="1">MKTTATLLCLSALSSMATAATEFSINVYEGPTECDDENKVKVGDSLSMHYTGTIDESSETGEKGMQFDSSRDRGNTFDFKIGQGMVIKGWDEGLIGVCKGAKATLVIPPDMGYGAQGAGDAIPGGATLNFDVEVVEISDKDPEQPNLFEMLDEDGDGKLSKPEIEAFFVNQGGTMPDGLWEDEDKDKDGFVSWEEFTGPKGASPPAHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMQ4</accession>
    <name>A0AAD2CMQ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="157" mass="17617" checksum="B699BD6CB08C4DFF" modified="2024-05-29" version="1">MNHQSNKNLSTKTRCSSGIQERIDALQKSSGCHHHHQQENQTRPSGRVSKRPSLNLSDLQHSIYSMENSVSSLDLSNSIQLPLTPGGVVDENAEEQQPTRTNTAQRSVSFANMADVCFIPQLDDTVDYGVLYYKEDELADFRHEAFLEDCGLADMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMX0</accession>
    <name>A0AAD2CMX0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042091803" evidence="1">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="207" mass="21480" checksum="F4686E94FE45B244" modified="2024-05-29" version="1">MKVLLSLALAFVALDASQAHASWSFITATGLTAEECAGLTILAGVNCCPTKQDPAICFLCNSAEATFNADKAIPDSEVPSCGIIDAMLSYAESEANCTAGKAEFDTSFNLASFCECSDVPAPELCKVCDDNQVVTTNTTAVVPDGDGLTCIEGFEFARHVTNQTVCDGIETDESKAACCVEASSGISLCMKSLVVAATLLLGVMYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN08</accession>
    <name>A0AAD2CN08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mesencephalic astrocyte-derived neurotrophic factor homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">MANF/CDNF-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS6860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARMET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045333">
        <property type="entry name" value="ARMET-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019345">
        <property type="entry name" value="ARMET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045332">
        <property type="entry name" value="ARMET_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990">
        <property type="entry name" value="ARMET-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990:SF5">
        <property type="entry name" value="MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10208">
        <property type="entry name" value="ARMET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20145">
        <property type="entry name" value="ARMET_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042092108" description="Mesencephalic astrocyte-derived neurotrophic factor homolog" evidence="8">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="ARMET N-terminal" evidence="10">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="ARMET C-terminal" evidence="9">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1940078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="166" mass="18821" checksum="7BA302AA3B905FA4" modified="2024-05-29" version="1">MKFVAFLLALAYTATVAMAAEVKECEVCVKVMDDIRASISKEDSRKKPLVEKAMGDYCADEDKLSAREKKICYYIDPIKRDVAQPFSLGMPSLKVCKRITKSNPEICTVKFPVKTEKMEKKDISKLRVKQLKAILSERGVECKGCVEKEEFVKKVQETEHLSGDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP10</accession>
    <name>A0AAD2CP10_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000480">
        <property type="protein sequence ID" value="CAJ1935531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP10"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="194" mass="21617" checksum="B6391150418AEB7A" modified="2024-05-29" version="1">MGRPKGSKNKKCNKKAGGDQKSKKFQTAKEEKAKRSHEYFLSWQHQNDSSSVKSPHPMEEAIFKISKELMAEVFDHLSKPKGKFVQGTVDFTSGNAWEVKYDEDNDGSANGIGDYRIGASSDDDKSSASSTRYCQSYTPSQGMPLYNYLMEVQGKIVDDKNCKQQKFIHPSKSPLASGLGKSPNPSNFYKDVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPD1</accession>
    <name>A0AAD2CPD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protochlorophyllide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS2682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000202">
        <property type="protein sequence ID" value="CAJ1932083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1932083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20233" checksum="73402667AC3F3D03" modified="2024-05-29" version="1">MPLLETGAAAHGEARIVTHSSGARDMCQTPNKGLDAKFLGKNGGKLGGDELKLFKGPVFERYFQSKLANSVHMHGLHERLKDGKIKAISAHPGGSDTNLGDHLKFGYFTDMFMKTVFSFMAQTSEDGALGLLRGMMDPEAESGVLYGPKKSGISGPAVPNPPKEYETDPKAIEMLFKASEEAVASFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPD5</accession>
    <name>A0AAD2CPD5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS7613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001057">
        <property type="protein sequence ID" value="CAJ1941664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1941664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="458" mass="50651" checksum="5EC05D3B4C050C8E" modified="2024-05-29" version="1">MFKIRQSKYRHIFCDQPKTELCYTGFRVATTTGETQYIKASTKYWAVAMFGGGGPLVVGRHDRPGRFEDGTSPILKGHHGSVLDMEWSPFDDSLLATGSEDSTIKLWSIPDDWEPTDERGLGKEGSHISESMIDLEGHDKRVTLMRFHPTASNTMLSTSADHTVKVWDVEAGEAITSLDGEISDLSQDIVWDVRGDKYVLSNKDKAIRFVDPRTGAVISKLEKAHEGSKSVKLSFLGESGKLLSTGSTKQSGRELKIWDLKKMDKPLHSETIDTASGALMPLYDQDTSVLYLCGKGDGIIRLYEFENKEPYLHKLNDGFRSTTPGKGYCTVPKRGLNIMNCETTRIMKLTNTDGIHPLHFTVPRKSDAFQDDIFPPTAAPTPAHSCEQWFKGSSKLPKTMKLDPNSMSGGGSKGPAAGKRVSIRSLPTLSKEVDALKKHVAYLEGKLKAAKISYDPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPG4</accession>
    <name>A0AAD2CPG4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000213">
        <property type="protein sequence ID" value="CAJ1932215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPG4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042177850" evidence="2">
        <location>
            <begin position="23"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="382" mass="43023" checksum="1E6E48108ADAEEAE" modified="2024-05-29" version="1">MLSLRSIIMIFLLLAMQPMAMPSLMSANYTRPSIQVYSLANENIVSTVDFVGTTVEMESTGVPSFSLAEFVMSIDYESVKAFTQDFSKKYEAFAEAFTDAMSAIFELFSMEYNAYKQSINYESIKAFAQDFNEKYEAFTQAFTDAMSAIFEYEAFHQSIDYESVMSLAELLNEQYEAYTREVSTAMFFKIGLFIQKLEAYNQEFRVKYQRVYKELEYVATDLLAAAPAWLSFDHEFIVRDVFDGVLSYTTMEPFVPAPVPPLLSLEDAQLIAMEVLDSTAFGAIVIALLVAAVTMIYASSVIDRGLVSMEDLSIVLETPCLSMTDLRKKMTPSVILRSADAYARYQASCDKSKDPSIVDLCSLFANISFLKDTTDPSKNESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPJ0</accession>
    <name>A0AAD2CPJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6816 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000702">
        <property type="protein sequence ID" value="CAJ1938318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049213">
        <property type="entry name" value="DUF6816"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20670">
        <property type="entry name" value="DUF6816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6816" evidence="1">
        <location>
            <begin position="72"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="294" mass="32459" checksum="95E4873FD6703E91" modified="2024-05-29" version="1">MTFAILPAFASTLSLLSVDRRSVLGTATTAALWISSCSKGVAAPSIQSKISESILTLPPPSYSTEFKGNDITLFPSFLEGEWQTIQTLVSTTTPLGLKYLGGPNGDLSIAEKTMEQSKSQIDKPVKLKLRYLPTRWGVAEDRLFNTRQRLNAFAGKDVVASVQYADVGGSNRKSVLLLGGTEEDPLQTTMVYFKGPAAQKSFVVAHGNESLGDRKWVVYELQRSIFALTNQNTAPPVTTDTEYIWKFEVIDDSHVEGTLRIAAYLNAQNDKLYFEARNRAVSLQDYSLKMERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQI0</accession>
    <name>A0AAD2CQI0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000288">
        <property type="protein sequence ID" value="CAJ1933618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQI0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="67"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="431" mass="49307" checksum="6E5E1E2FFB3E3196" modified="2024-05-29" version="1">MTRDRYDVDLSIINDRERSAEIQFSAQEHIQDENQQTVANHRMPMAPTQIAKHNALSWRTDPVSSFSDWRIVIYSISKEASVTQTNFFCHSNVLAWGPRKGNFFVELFEKQRRKSDILVSKIKMNEEEAKMIPIVLDFMYCGSTLPLSADRLHILYGLAETLDIPKLKEAMQLFVQNAMDLNQLVDFLTFVSDRNIGATIQRLVLLAESRLFGFLVENVERGSLVPPQILYRILQKRKQCIGVLKKRNPIKYTRRWENERSKVIGRIIGECCVQAVNTNRPSPSLTLRMLETITNRAILPAIDGETALKILQVEGVLVQMSKCGSEHAQHESRMNDTNLLQLEKRCILMLVPEWRRMLRDNRPSIAVAMKTFTPTALAELLLSVSEMYEIGTSAPEPISTAYLENSAFQIGHSEADVLEEMVAEESFIDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRK8</accession>
    <name>A0AAD2CRK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001147">
        <property type="protein sequence ID" value="CAJ1943839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="234" mass="26752" checksum="335B6D4591888B3D" modified="2024-05-29" version="1">MKAIIETLLSEDEASRALQGYNFRENLVDALLYSFETHKDELHQQSAGSGYGKSRLLLELAEQDQGNVRLIIYLSFATTQAYPKSTGSKKQITPDLLRCAYRRTAALVVDDAHKGIDWLIPVHLGSDKFKALVGQDKNRIGDSFSNLQAVSNEATHRKVTPQYYLTKEEKEEFQKAQMSLDWPAVLFAIDGDEEKIGWVESSAMTLRSRTSRRQVSLYRLDWTWIHQAHECRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU14</accession>
    <name>A0AAD2CU14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">signal-recognition-particle GTPase</fullName>
            <ecNumber evidence="10">3.6.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS5157</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="13">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1936369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="625" mass="67010" checksum="6DFE98C233EAA299" modified="2024-05-29" version="1">MVLAELGGKLRDSLRKLHTHSGHVTQSHLKDLLGDISRALIESDVNVKLVMELRNNVNDKVQTLIDEDEEKDSSKNSDADRRASQVSKHVQKVVVEELVQLLQPQRKPYVMKRGKANVVLFVGLQGAGKTTTIAKFANYYQRRGWKTAMVCADTFRAGAFDQLKQNATKLRVPFYGSYTQADPVAIAEEGVDQFCKEGYEVIIVDTSGRHRQEAGLLDEMAEIADAVAPDNTVLVMDATQGQAVFDQASAFSNVVDVGSVIITKLDGHAKGGGALSAVAATESPIIFLGSGEHFDDLDPFNAQSFVSKLLGFGDVRGLMEAMNGQTDKKTQEEMMEKFSKGEFTLRDMYSQFQRVMNMGPMSKVMGMMPGMPEYLIPKNGDDQSTSRLKKFMYMMDSMTDAELDGKVDFITDKNADHVKSRIRRIAAGSGTHPKEVMMLLQVYKQFEGMVSKMGKSGMIGKDAQAKQQQMAAAMQRNPKLIQQRLNQMDPRMIKQMGGREAVQTYLQNMAKGGGAPGGMPGMGGLPGMGGMPGMGGGMPGMEALMGAMGGGMPGMGGGMPGMGGMGGMGGMPNMGGGGGGMPNMGGMDMAKMAKMMQAMQSMGGMAGMGGAGGMPDMGGMPDMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUI6</accession>
    <name>A0AAD2CUI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="547" mass="59439" checksum="F88B482C0DD9710C" modified="2024-05-29" version="1">MAEVTVTFKKKKNEALGLGIKKIAGKDGIFISVIQPGGKIATAAPDLKVGMELLKFNGKAVPSTVPETLAKLKSIKGKLKVLAKETPPESPSRSRSYSRSYSRSRGSRSYSRSYSRSGSRSYSRSGSRSYSRSPSRSYSKSRSRSYSRSRSRSPGSRGSRSYSRSGSRSYSRSRSYSRSRSRSYSRSPSRSYSRSPSRSASYGKGSYSDEKSFASDSHDGSAAPKNSPPKPATPPPPPKPAPAKAAVKAAPKPAKTQAKEKEAPMVTDTEEDDPGVDECRRIIHQIWNQANKEEEEAYTAKRAAAKAQSQASVAKPPPPPPTRPGAKASVGDAQVDKPTWNRSPLPNKDGSPASGSKSPKSGSMSRSGSRSYNSRSRSRSYDSRSRSGSYSRSRSYSRSRSGSYSGSRSRSYSGSRSRSYSRSRSRSHDSRSPSRSMSRSEGKAEDAPPTAAAATPAPEPVQEMSLNERRLAITAILKDSSLSGAEKQQRVAALRPKPVVRTTTPMQQEGEESEATKRRKAIQAVHADKSLTPKEKHTKIQELLNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUK3</accession>
    <name>A0AAD2CUK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="308" mass="33743" checksum="5D3CF93995B9B272" modified="2024-05-29" version="1">MEQLAHKSTPVSHSERRDPSNTAERGGDKPTRRRSHRPRGCRGGSNRRKNKGGENKNSLNKPKRGLTKKQGSFKNQRSSFNKGSKASTLNALSVVGSHAPANMGRHMGVHEYDQAPSLQEYGYGAQPGDMYYSPNSSSSSGTDLQESLSESSEDCIPNPNSRSFHLDPHDGGLILPPLASTNLQEPEPVKFRGPNPYALHQSNIHNISYPRLPVYGMHNNNNNHHGNIAQIPDGDDTKQFYCHGNGYSENPAHADVLALNLPGLESKMAQLSKQQPPRPVRSGGSLFCTSPRSFLMGTTKDHSTTRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWH5</accession>
    <name>A0AAD2CWH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001546">
        <property type="protein sequence ID" value="CAJ1945842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="160" mass="17899" checksum="0CC22B4CB9D02E59" modified="2024-05-29" version="1">MVICGINDATLFQGHTHAERIAYEIFSDDFSTTMDVSIDKLNDELKTLAGMTAAQGQIRLMPERSIDVEGKGRDAFTTLRTHYKGEGLLAHNIVEAGHTIKNLCYVGEKPTMNWAMFERMLKKAYAACDKHEGRVVHLEAMKLRSLQGYCIVSTTEQDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXQ1</accession>
    <name>A0AAD2CXQ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000946">
        <property type="protein sequence ID" value="CAJ1940723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXQ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042275840" description="Kinesin light chain" evidence="4">
        <location>
            <begin position="21"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1940723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30011" checksum="76FAD6DC4F1D3356" modified="2024-05-29" version="1">MKFLLIFSILLFYSVQLCHGVNEPSEPNTDQQRLQEEITNLHNAANEFLAAGELDEALEKYEESLIVIKAYFGDEHPNVAAIRYNIARVLYSQNKVDEAISQAEGALDMYAKVLGEDHAIVSSTLTGLTNILVEQNRLDEALIKLQRDLAIQRKIHGEKHSAVAEKLRGVGMIYFKQQNYDEAMETYAQALEIYHSTVGEGHISTADTLDQMASASFHLGKLDEAIEFAEKAHDITSKELGESANATLTASDNLAFYKEQAEAANTEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBD6</accession>
    <name>A0AAD2FBD6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1920493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006970">
        <property type="entry name" value="PT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04886">
        <property type="entry name" value="PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042169866" evidence="4">
        <location>
            <begin position="18"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="660"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="797"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="838"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="930"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="953"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1682"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1778"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1791"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1837"/>
            <end position="1849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1920493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2090" mass="204522" checksum="C44C33BE679F830E" modified="2024-05-29" version="1">MLRLILLLQALYTTTSSDSNTLQQIRQVGQNEQSRPHVIDGRILTEELTPQHTTSSCNGFLGLPCLCNGESEQTGVRGFFCQLETRVERRTAWLYRYFGRRQEQKKVSLAQHCDYDDPNKIKFCPPVNVRSRLAVNHNPNLPYNGPMSNASEALPSKCLEDPDDPDCRKLTRNDSSSISSSGSRPAAQAATVASSSNSGVSRCLQEGKIKLISEDANVGLPAGAVEVVSSEDSSVTFKITQLWKSSRAGWIQPAYKKDGKTCDLEDRLSSADGGFSVQFKAECLGSKAALDLYVQDSTFVGAHASDFHDCLDWSSAVALYSFELACDGSNLCAVSAEQSDETTSNDETTSDDEPTLAPTTLAPHHFVSKTPSGALSTSSPTKDMCYGNMLKSNGKFCHSEMPSVSAEPSEQPTGFGPDFEGEEQRPSSDAPSDVPSQAPTNLSSDSPSDVPSQAPTGPYVSDMPSDVPSQTPTDLSSDVPSDVPSQTPTDLSSDAPSDVPSQTPTNLSSDAPSDVPSQTPTDLSSDAPSDVPSQTPTDLSSDAPSDVPSQTPTGLSSDVPSDVPSQTPTDLSSDSPSDVPSQTPTDLSSDAPSDVPSQIPTGLSSDAPSDVPSQAPTDLSSDAPSDVPSQTPTDLSSDAPSDVPSQAPTGLFGRDDELFSPKTDGPTSGPTSSPTTGPTSGPTSGPTSDPTRGPTSGPTSSPTTGPTSGPTSEPTSDPTRGPTSGPTSGPTSGPTSEPTSGPTAGPTSEPTNGPTSGPTSKPTSGPTSRPTSGPTSAPTSSPTSSPTEDPTSGPTAGPSSEPTNGPTSGPTAGPSSEPTNGPTSGPTSRPTSGPTSDPTSGPTARPSSGPTSGPTSGPTSRPTSGPTSNPTSGPTALPTSGPTSGPSSGPTSGPTSSPTSRPTSGPTSLPTSGPTSSPTGGPTGGPTPGPSTSGPFSGPTSSPTGGPTGGPTSGPTSGPTSGPTSGPTSGPTSAPTSGPTSGPTSGPTSGPTSGPTSGPTSGPTSGPTSVPTSGPTSGPTSGPTSGPTSGPTSGPTSRPTSGPTSGPTSGPTSGPTSRPTSGPTSGPTSGPTSGPTSGPTSGPTSGPTSGPTAGPTSGPTSGPTSGPSSGPTSGPTSGPTSGPTSRPTSGPTSGPTSKPTSGPTNSPTLGPTSGPSSGPTDGPTSGPTSGPTSGPTSGPTSGPTSGPTSGPTSRPTSSPTSGPTSKPTNGPTSGPTSGPSSSPTSAPTDGPSSGPTSQPTSGPTSGPTSGPTSQPTSGPTSQPTSGPTSGPTSGPTGGPTGGPTSLPTSGPTSSPSSAPTDGPTSGPSSQPTDGPTSGPTSGPTSSPTSTPTDRPTSGPTSQPTSGPTSGPTSGPTSSPTSAPTDGPTSEPTSQPTSGPTSEPTSGPTLGPTSGPTSGPTSGPTSLPTSGPTSGPTSEPTSGPTTGPTSGPTSGPSSKPTSGPTSGPTSGPTSRPTSGPTSGPTSKPTSGPTNSPTLGPTSGPSSGPTDGPTSGPTSGPTSGPTSGPTSGPTSGPTSGPTSRPTSSPTSGPTSKPTNGPTSGPTSGPSSSPTSAPTDGPSSGPTSQPTSGPTRGPTSGPTSGPTSGPTSGPTSQPTSGPTSQPTSGPTSGPTSRPTGGPTGGPTSLPTSGPTSGPTSGPTVGPTSGPTSGPTSSPTSAPTDRPTSGPTTQPTSGPTGGPTGGPTSLPTSGPTSSPTSAPTDGPTSAPTSQPTSGPSSGPTSGPTSSPTSAPTDGPTSAPTSQPTSAPTAGPTSGPTSRPTSSPTSAPTDGPTSAPTSQPTSGPTSNPTSVPTDGPTSAPTSGPTTGPTAGPTSSPTSAPTVGPTAAPTSQPTSGPTKETEGNGDPHFKTWKNEHFEFHGQCDIVMISNKDFAGGLGIDIHIRTKIVRFWSYIENAVIRIGNDILEVSGSLDLEEAKYWINYEDGGDLEDLAGFPISISPSNNKYTIDLGSQYRGEKLEIRTFKEFVGVKIIGATESSFGNSVGITGDFRTGNTYARDGSTVLDDFTELGNEWQVLPSDGRLFHEVARPQFPEKCWLPEDPRGERRRRLGESTITEDQAEAACAGLEDEFSRKGCVYDVLATQDLDMVGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FD29</accession>
    <name>A0AAD2FD29_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FD29"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35399:SF2">
        <property type="entry name" value="DUF839 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35399">
        <property type="entry name" value="SLR8030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="PhoX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="729" mass="80464" checksum="0729504C95EE0161" modified="2024-05-29" version="1">MKSSSSSSPTRDSASSSTSLSRKGLPQNEQIDSSRSNVRTNSQFKPKKSKRRKSNKKLPKQESGTSTGRHWHLQRNLIAALFMVIFVISAVFAILQLRVRSNQDDSASDQNGVQNNPTLAPPDIADCHAANSNSTNAVPFSSLQPQLLFVETNVVMPKSTSVIGALSLLSTVMASEMENLIARDIAEHGCYGPQAKNSNRDSQGIRSINVIPSNHSETGACVLHDDKSCHKIDFTVELLLDTYINVNKYLLIRTLDETLDGNAIYKRLVDLDLAVDMVQILSVTEIQRTSPPTKAPTTPIDDMIGNTTSTPTQIPSKSPSSAPSETIITYVPGKLTVRSNGLLLSEGLACRILAKTGQPVALTGLASANETVPVSNNVFHIEPDGAGVFEVIIADHDGIHRHLVEGGWVYISNSENENRGEGGVGGLYFNAEGEVVEYRRLLDGTTDNCSGGKTPWGTWVSCEERDGGRVYQVDPMGIRPPQIVSAIDDGWFEAFAYDIRNPSQPRFFVTEDHPEGALRRFTPTNANWEDPWQLLHSEGTLDYLMLEPYSTLSPNAGGTFSWTSKLSKAQKNADEYYQYTEGIDVYDGELFVVSKLQKQLFILDLDAQTYQVHSTISGVFDGMPDQLKRVVHGDGDDQYTLLYFTEELGAENGVHARDENGWFFSILESDVTLDDEATGLAFSPDGKHMYLSYQKTGMLYDIWREDGLPFHGKTLNVHYHSVENGRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDN8</accession>
    <name>A0AAD2FDN8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000313">
        <property type="protein sequence ID" value="CAJ1933882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDN8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021466">
        <property type="entry name" value="Put_rhamnosyl_transferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11316">
        <property type="entry name" value="Rhamno_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="404" mass="45955" checksum="90F675A11680B1A6" modified="2024-05-29" version="1">MAAFFNAHQILLFIGTTIVLSNFLIASRLPSHELSGGVRLLRESQEQTDVGLFSEKDESEEEKAMLHIVTTRFMQSQAGLTKLGKARLKLFETFCLPSMQTQVIDNFLWFVMIDPNLEGELLERLQFLLAPHPNFFLVLSNEKLLTPHNLMNKQEVVQIVSGETQLLYSRMMDVNRPLLMETRLDADDGLHRKTLGQIQYAAMKLPQATGGWQVICADVHLEWRNDEIANLNSTVESSGRIRLVKEDICVTPGYTLVRHREPGSNEFPPWPKMGHQQMNTLWPECLSSNSTKEGEPVNLNCWTRLPKYPAALRSRTITSAGMSRVRSSAKDRIYDEQTNDLWQHVTRDFGIGEERTLLTSQYLQNNIHGIAVDNLLGQCTRGHSCKRSSRDKLEALAKETASFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF64</accession>
    <name>A0AAD2FF64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1903301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="13"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1903301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="426" mass="46592" checksum="469671DBC2FB553E" modified="2024-05-29" version="1">MFRRLADRVFNSSTEQQNVNTLKNMGFSEADARNALQQTDGNLEQAANILLARGPSTQHNSSSAPARDANRQQVEDDELQRALQASMMTTSTTTPQLASRNALPKPAPKRKPKTAAATNAGKAALTRANTPPNSAHSSRSSSPAISSHPNVKVPTKLSNKSKEEQILRTADRLKSSPSALDTLYKTLKTLQSNPTHPKFRRIDQTTAGYQKSLANAPGAEDLLLAMNYRKSNGHILTLELADPATLYLGISALEQTRLTPEYLYGKSLQQFHKELRQAFHSADNSAQEAIARSQHMSKLPTEPTMGGAWIFVNFEGLEQDSQYKLKRKFDADDTLGDALHWIAGNGTEILTKLQSGEWELVDGNRHPPACLDVSNASSRTLQYIGCWPSGKLIIRPKSSTNDGMDAQQESQQPSHARGLGAAPMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGV3</accession>
    <name>A0AAD2FGV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000624">
        <property type="protein sequence ID" value="CAJ1937277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20404">
        <property type="entry name" value="Tudor_Agenet_AtEML-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="55043" checksum="74B1B510A9C1DE92" modified="2024-05-29" version="1">MASTSKQEKKKKGEKSFKTNKKQTTTIAAASNYDNDDDDNDDDDCAPKLLLDHETRQLRKLKSLYQSCIFKADAMALQKSQGHSSSPEPVDVMQQQQQQLVEKTLCQPKHSSLKTWVELQQQMYDCGIMSDKQQDALWNAGVDLVARSESSKERTTSKETKAKAEIPTKATLAVADDTAADWQQHEQPIAVVVKQQDGTIEDKFLFSPETIREKVGSLKKELLEENPFCETTICCEKNLKRKRLNNKKNKNKKKEKKNRSQGSSSSSTTTNTSSSKRAKTNKEEAARISPTTTSTTTATTGESSATTTTTTFQAAPSEAAKRKRTHPKQPSTVMVGDTIWVHYEDDDWWYKGRVLASTQNYNAQSNHRQGLVTVQWEDDKYNDSQEALDVNNNGDAYCWGVDNDPNANFNQEKEELVSTLNIGCQLSIYWPAEQESFPGTLTKMDKSRKEKDIHYIEYEDGDCEWLNLNQRRFTILNYDDNNEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHC9</accession>
    <name>A0AAD2FHC9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS2558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with ribosomal protein S21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000180">
        <property type="protein sequence ID" value="CAJ1931814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHC9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000017">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1931814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="282" mass="31066" checksum="70FF3993F2CC93BA" modified="2024-05-29" version="1">MASFSTLPPILQPKEEDIQMMLSAGVHTGTRNSDDSMKEYIWRRRNDGVHILNIGKTWEKLILAARVIAAIENPEDVIAISARPYGMRAVLKFAHYTGAQSIAGRFTPGTFTNQITKQFREPRLLIVTDPRTDSQSVREASYVNLPVIAFCDSDSPLQFVDVAIPANNKGKFSIGLLYWMLAREILRLRGSVSRTSDWDVPVDLFFHRDVEELKKSEEEQAAKAEETAAVPAYEAPIAETMEPAAMETPADASFRPADAAPYGTSWEGGETTSAAAAAGGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI31</accession>
    <name>A0AAD2FI31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="321"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1940376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="662" mass="71942" checksum="7C25CABA5EE44AFA" modified="2024-05-29" version="1">MLARWFDRDGIGQYLAPDENAAKQVVKEEARATFWQIVAPDPKFSERQAPPQDAFAMLPGSPNQIRCMHCHRWTDISKGAGSENKGETPGKVPETPKQTSANSFTTPKKQYKTPKDKIDEEINALVLSAAKETAASMTSPSHIREARDKIFRICGCQKPISDKITKRLRNSFKKNPKLLSSRSTHLGQLVPDGYTPLMACAHAGNGIAGAVVLEMAPKGCIWETDLQGRTALHIAAETGNVDMIDLLIPKLIQANGMKSPPPVDILGRTPFGTAVTSPNPTAKKRRKELESALFSPGDLSVFGHAKSETERGGQCPELQIAYGMADMPGMRVQMEDAVCCETWKQSGKSYCVLAVCDGHGDRGSVSQFVADNLVTVLKPHIDDMESTWQEKFEKACLTVDANLKDEGIPGGSTAVIALTTESEIIVANVGDSRAILIQSSGTNLEAKMEKLALDGSKDTDAPPLQQEGEKTGESSENEKSVIGLSEDHKPNLPEEQARIEAAGMKVNAVIFQEDGKEVTIHKVALSEKDQLAVSRAFGDFEYKLNTSLPPEEQAVVAVPEVRVHKRDPDRDLYLVLACDGVFDVLDNKQVMKFVLDQVSVRKEITDTVLPEVGDALLRESLNAGSKDNMTVVVAALSKESTGIKTIIQGRTLDFTSPDVVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI62</accession>
    <name>A0AAD2FI62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS7976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01468">
        <property type="entry name" value="RNase_Mini_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008226">
        <property type="entry name" value="Mini3_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34276">
        <property type="entry name" value="MINI-RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34276:SF1">
        <property type="entry name" value="MINI-RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="5">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1942496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="163" mass="18770" checksum="70BCF39C077E5BFB" modified="2024-05-29" version="1">MVFRLSDMPQEEKEGDTAKDMPPKRKSLSELLLPIDTCKVNQMSGTDLAYIGDVVFELFIRSRHVWPSKRTSDLQNTVVAIVRAEHQSHLLKQLHDDFGLSDKEKQVLMRGRNAVARRNNRRNPAAYQDSTSFEALLGYLYIEDQDRCCDLLNWLESVVDNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIF6</accession>
    <name>A0AAD2FIF6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001079">
        <property type="protein sequence ID" value="CAJ1941792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIF6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="344" mass="38873" checksum="F1637ED83D8B3F2C" modified="2024-05-29" version="1">MLKFVTKAMDIKLRVEANFTTTLEDPIELLKRIEQFMKKSADAEYDFLDFWEANQKFFAMKQGTTEDLMHFNERFLRQAEVLQKLYVVAWIRDFAVKTKAYAAIASTDSAAQNKFKDYIFEAVLATGFLCNCNQTRTAPLMLDLQTNYCREVDYYPKTVSKAQDMLKIHMEVIENPGVNLYQGKDQPNKGNQMMQVPSGMQLMQIPTQGGGTVTVPYSMNANGEIAFSGMQLSRQGFSGAQVRQGFDATQARTPQAVKTGYFDTSNVFHDAIKGKHENGNDVYLIPCPAGTINVKLQANWHYASENEDLPDLATEADQGLQFIQSCRREKDPFGLHDHVIMDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIX0</accession>
    <name>A0AAD2FIX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001158">
        <property type="protein sequence ID" value="CAJ1943898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="2">
        <location>
            <begin position="54"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="180" mass="20119" checksum="0F17A728887305BA" modified="2024-05-29" version="1">MRDNLWTEAADTATKLDTALVYQRGEQSSHKKFWKQEARFARHLKTFGEMAVIKVHTKIKGKLKDRGRTVMFVGYADNSSGDTYKFYDPKTKRISSSQDVSWLNKSYGDWKGIKKTNTLRLTQEILLETANDNDIVQAPTTQANGANTTTQETGPIPTAPAATERATMPAVQLHLGADPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKL8</accession>
    <name>A0AAD2FKL8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001542">
        <property type="protein sequence ID" value="CAJ1945835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKL8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="357" mass="40924" checksum="96530749612DB95B" modified="2024-05-29" version="1" fragment="single">DIEPAHIQLCLNIDKGEYERVMAYRNIHKWSEIDADTPIVWKLKQVVCCHHYIRLEHPSYLGLTFCMAIGWKHGENTPEALSITGADDSVTYTIHARNHNLLESQDCKPLENIVKDKWKFLCPTNQVKLRLLHTTTPKYMYYYKIQKEHNDVLQLDKPHGNTNWKHATKVKIDLLARFKVLVDMGRGIPTPKDHQKFQVRHFNALKHCDKHKPRLLPCGDFTYIPPNKTKPYCLLTEQLVAGIIRHMMNGTSINFLSKEQSTVGTATYGSEFVTTQTCVKQIMDLQQTLRYLGVLIRGQSYMSGDNESVMNSSSRPEAKLHNQHVALSFHHVKEAVAANMLSFIHIDSALNPADILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLL5</accession>
    <name>A0AAD2FLL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001057">
        <property type="protein sequence ID" value="CAJ1941676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="16793" checksum="A16D8BDAFFF96000" modified="2024-05-29" version="1">MTIGSKHGEKTPEPLRITGADDPMTYTMYARNHNLPESQGCKLIRNIVKEDKQKLLCPTNQVKLRLLHTTTPKYMYNYKIQKDHNGILQLNKLHGNANWMHATKVKIDLLAMYKVLADMGRGTPTPKDHQKITKRSPKVQSPTCQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLP0</accession>
    <name>A0AAD2FLP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1942130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="422" mass="47637" checksum="119E8E9DF7394C1E" modified="2024-05-29" version="1">MTDNTCSICLEPLISAEHGKSIGTAVPCGHCFHTKCFHRWKASRRTRIRVPCPNCNKTTDDFIKLFISCDIEDLQCLPIEEPQPKPRKSPAVVICPSPPRLASPSRITQGDPPSTPRPLVTARRISSDDTMNRAATAPSGRTPRRAAAELLGRNPGSTRSSSRLSPFRARVRDNNSQAPVISSRRHSTRSLGRMLQLSKMVKDLKVAQQSIVKQVHDHRNIIFTLGTCRQDQQTKRICKLRASQSKLTNDMEDHCAAMEDIPLDSLRRRDSRRIEEMQSELEVKKTTHREQSELVNTLYTTRLTQERARVARLREEQRKLNDTLRDYGAAIKALHHNRNTNTGGIRLRGRKQRHLTDRVGALGDAIQSINLNMLERDHVKKMKHAEDGLIALVQRVGDHGASIQSMCSVHHFLGTLLPDHEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMG8</accession>
    <name>A0AAD2FMG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS9830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001447">
        <property type="protein sequence ID" value="CAJ1945685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000464">
        <property type="entry name" value="Ribosome assembly protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="6">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="242"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="456"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1945685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="532" mass="59345" checksum="F1B0B61039F42EC5" modified="2024-05-29" version="1">MSGDKRTGGIAWAGSLVGSENPKSLGYRYSNPAKRYRKDGENEEEHKLPTNLVIQFRNRQGEELADNLDVPTGSSVDDLQALIRSLLEQQGDGDNAKIPYSFYAKVEKNGVLDDVEITHRLSDFLNENKVSTEDVLQLTYQPLAVFRVRPVTRCTDTMPGHTEAILHVSYSPDGKHLASGGGDTTVRFWDVNTSLPKHTCKQHKNHVLCTAWSPDGTRFASCDKNGVLILWDPTNGKPIFSKKAHRQYISSLSWEPMHLNGGKCERLVTSSKDSTCKVWNVRTQQCLLTLSGHTDSVECVRWGGEGFLYSASRDRSIKVWTMKDGDVPGKLVRSLKGHSHRVNTLALSSDYICRTGPFDHRGTPFASREEGFQASVEKYKNFIQQGHERLVSGSDDYTLFLWHPTQEKHPIKRLTGHQQAVNHIAFSPDGRYFASASFDKKVKLWNGFSGDFLNTLTGHVGPVYQVAWSSDSQYLVSASKDSTAKLWEVPTGKRARATLPGHADEVFALDWSPNGASVATGSKDRTIKIWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMI5</accession>
    <name>A0AAD2FMI5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="184"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="257"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="339" mass="38754" checksum="16435320E3A57F55" modified="2024-05-29" version="1">MSDEHLITTSDLISKTPDMAFSQDFQSSCSKSPTTRKLSSSHTDDAFFRGLKSSFTPNSIANDDLEPTPLVLEVEPTPFKAGTSLQLASSESPIDSATRDGTMVFKLSPSNSSTTPNELHQDMPWNELVTFVETSLDSPSKTGKRAMPPPLAEVKAYGNQATKRRRTVSNANMNKTPRLRPHQDVLWQEHFSSLIKFIKEHGHCHVHYTCGHSPGLSKWVQRQRYQYKLKTAGKKTTMTDERQHKLEEVGFVWDSHAATWEQRLNELAEYKKEHGDCRVPSTYPQNPQLAMWVKSQRRQFKLYREGLNSNLSEERLQSLNELGFTWELRSVNDISDRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNB6</accession>
    <name>A0AAD2FNB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="527"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="569"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1947075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="76339" checksum="209A46348FE379EF" modified="2024-05-29" version="1">MVDRISTFNEMGASEFHSGHFETSEMCFCQAVSELGIGSSLASKGLRSSPQNGDVTMMDSRDDGLVVNPSRYDEGMNVYNTPLNLLRDCGDGKEQDGFQHITAAVVAYNMAQVKIKCGKRNHAEHWLHQALYWTKANDHFSQTLVVKILHCLGFCRYVTGEADMGMEYYQKAFNTSKYFKLGRQYLAASLNCIGVLQFSMDGTCNVDKSLQSFEECLQMYRSCKSFDPLAVATVHNNIGRLHYLRADYVQALQSYQESLKIRRHLLGEESIDVAATLYNAGQACQQLKKFEESINHYKSFLSVAKSVFGENSKDAALALKGIAEIHQVQGKFDTALEFFHQALQAQTAASGRLSTDVATLLNKIGNLCYEMKEYDTAMASYTEGLEIECSILPPDHPYTIITQTNIAHIHKQLDQCEKALEAYERVLKMQVGAFGSNALVLAETLSFIALMQYHLGDYASSLEAYQFALRIYREHSSNNDNPRIASTLNSIGLVFFKKQAYELANMCFSESLRIRTKLLGPNHRDVAILWYNLATVYFERGEEETAVKMYKETLRVEEMHLGADHPDVGLTLRHLGQVHQQLGKLEEAAKYFQQVVAIERKREVAPNTRSSLSKALNLLGNVYLQLNQVPEMMECYVEASRLNEAPRETSDDTTSDRLVIAGYNLYCLQKTNPPAAPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ43</accession>
    <name>A0AAD2FQ43_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ43"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11885" checksum="D4C37CE683DF49E4" modified="2024-05-29" version="1">MALVYYDQGRFPEAMTMNTKALELMKKQLGEEHIQVAEIYHNMGNILRTINFAECMEMLDKALQLKSKILSPAHASIGDTHCRKGDAFLANSHLDKALESYQKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQT8</accession>
    <name>A0AAD2FQT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PS II complex 12 kDa extrinsic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36327:SF1">
        <property type="entry name" value="OS03G0731100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36327">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041988711" description="PS II complex 12 kDa extrinsic protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19360" checksum="B0A9529D1846FF1C" modified="2024-05-29" version="1">MPLTISALSSRATSLLFLFLFVAPVAFGYQPSQQPNNAQLNRRNFFAFAAASAAANILIPEQPANAVLSAKYCAYGSGDGCDDLAEGNDFIRQLQAKSAANKEKNESDALYSFYMKNYPDVFAVSGKTMVKKADGTFLLVSGEELMALKKDNRIGIENVKAMGGKVTDMTQKPVLVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRA7</accession>
    <name>A0AAD2FRA7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001767">
        <property type="protein sequence ID" value="CAJ1950436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="294" mass="33409" checksum="080EF7EF8A8AE778" modified="2024-05-29" version="1">MELNQKQDGLLLEQSSCVNLSIDLGPQCSKIYNNPLLDRDSHVDKAGSDFPGHRDLETFIKLMRNGLLYKMQQQKAETPKYGGLVIPFQMENWFGAFSTIWFIHHHHLQEPNCFPVPRKELEVLKKHQSTICAVARNMKDLRKKIGAQHEIQAMIADLAKLCFVPNNAPNNSNPSTHAKRKAVDVDVVATAKKCGQKTQSVNTPKSFGTWVVDINISPSKRYLQCKKDPKNLVRVFSCPVCKHAKRIPSLDKMSNNLHVQLEFTPSPRSPFVDWEQSKPSDALKRHKIYVASEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRJ7</accession>
    <name>A0AAD2FRJ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="112" mass="12392" checksum="DBA9B60E20676861" modified="2024-05-29" version="1">MVIKSTNATTETSDVSTMESLDVLPPKPKTPISHLFSFCTPKKQPMEDEDDVSDETDETDEITGRSLTFEPEHLEESIVKKEEEAREATLFDGGLLFQIGVVSAVLAFETLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRQ3</accession>
    <name>A0AAD2FRQ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS12759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRQ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="4">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="123"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1950792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41266" checksum="3BC1CB774817BAF4" modified="2024-05-29" version="1">MTDQDALPTVTATFPLIREILIREGIEIVHAHQATSVMANESVVYASALGLPSVYTDHSLFQFDDLAGVILNRVLQTTLSTLNAAICVSYACRDNLILRAHLDPSRVNVIPNAVDASKFTPDPSKRSKDRIKVVVVSRLVYRKGVDLLVGIIPKVAKQLPQVDFIVGGDGNKMLDLIEMVEREQLQDRVEFLGAVPHVQVASVLQRGHVFLNCSLTESFCIAILEAASCGLLVVSTNVGGVPEVLPSPDMAILCDSNVSALVKGVKAAVERQEGDGDDAVDPIQAHERIETMYSWHRVAKQTVQVYDRVASEPPQTFSERLACFQSLGGIAGFVAGLLLMIVEVWIRIVILWRPTSTIDVVPDLMPFEKAYTKDKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVE2</accession>
    <name>A0AAD2FVE2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M11 gametolysin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVE2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008752">
        <property type="entry name" value="Peptidase_M11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05548">
        <property type="entry name" value="Peptidase_M11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042223064" description="Peptidase M11 gametolysin domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M11 gametolysin" evidence="3">
        <location>
            <begin position="150"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="592" mass="64545" checksum="62682A15642A251B" modified="2024-05-29" version="1">MSTVSQQTKWRQALLSGALILQSLLLANGQATTALNEPCLAFVKDIFSEDRQQLLCQTPSGMLYILPSVDGQWIEEKMIAGELYSGETILDLPDGTTINREDQTLNLNEMPALVNSDSSERRLQQNTKTTGDRTVLAVRVIASNGEMSKSDEELSASIFGGANDFVNLKSQYAACSHGKINIVKRPDMNGLTSNIQNGVVTIRVNLPVEVGHSTMVNAVSQELDREFGMTMHSIADHVMYCLPKGNYNGVGFAIMNGGLSVFNDKLCTSVSTQMHEIGHNLNLGHSGIGTEKYGDQSCMMGYSYRSSEAPKMCFNAAKSFQLGWYDDKSKSMIPGTGPWGDDHTFTLSNIVDYPTTNDDVLIEIVEPASQKNYYVGFNVGKGFNQGTRHGKNQVLVYSKPVAAGIDSLRVADLSSGDSFTISDFNGITGNTLSISVLSIDLSSDLAQVRVTLNRKHSPPTPMPTRYPTPAPTRLPTRRPTPSPTLRPVAQTPSPTRPIGGRKPTVDDIPVTTSQSCKAAYSECETTSECCAGFSCRRVASDTGFSNVCRAIAKNSKDKLQRNGTPWWKRRLRGDSNVQAPREPDNEILEVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWT6</accession>
    <name>A0AAD2FWT6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001873">
        <property type="protein sequence ID" value="CAJ1954992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="175" mass="19538" checksum="562226DEB7392B49" modified="2024-05-29" version="1">MVINHIQDPQTLQDILNGIHKVFNVEAIPSNKTKDDFSQDTPTLVTEAVDSMASTVDAPKLAAFSQDETIKAEANHSNNKVKTTMLSGTTIKKLKAVLRKAAFLNGTKTECLMVECQVPSSTSIRNNIIKLNKISNGMFNSTVNKKNSILKNRRHRKIRRFPFMKSITDPKILVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYM7</accession>
    <name>A0AAD2FYM7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYM7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="200" mass="21794" checksum="13DF8FA98185EB4F" modified="2024-05-29" version="1">MTSIVPHLTPKTTNLSPGNKRRRLMPLTPTSQSSTPRHHDMAPATVQMPSMPSLSKIDDKGFMDLPAPTNRPRQRTESFDGAFCFDPAFVSPTVGQVRPRPNPNADLCIDHNSCNKRRPPFVDNKESDTFAAFTKPAEGSSFGASSSFIGLRGLLPEDARASQSSLARLLRRNSTSSAVGLDMNQVDDEAQPETRNEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYN5</accession>
    <name>A0AAD2FYN5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001929">
        <property type="protein sequence ID" value="CAJ1956987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYN5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="150" mass="17881" checksum="1B9783DB41CE05A6" modified="2024-05-29" version="1">MVDKLEREAEFENKLFNDPVELLMRIKKFMTTTVDTEREYFGLWKTMSNLINCHQKEKENIASFCKQFEERAKALQALLGDDFLNKFTEKSQEYDLLGSDAERLQHKKESWERFRAKGCLYNSDRAKYQSRIDGMTAQYTLKHLDFKQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYT4</accession>
    <name>A0AAD2FYT4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYT4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1957270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="646" mass="69958" checksum="AEB94434DABA8E8E" modified="2024-05-29" version="1">MVPITSVEMNGTSSAALETAVDAYAIRVLRRLSPPEAVVDESVGPYVTSLLRCADISSKDEVTKLPEFESLLELLEDQCSMENESATQAVLAIATAVCTGTIPSETRSRSASFGVFTTVGVQTRKRSQSFGLYSGGGLDSFKSMSDTSSKETSSEDVKFDSVFGEPFTPIQVGAPSPMKMEALVPVDLLGALNNPSPHISRIGGHAHFREAFEQQQQKQEQELTQRNQQEQEQEKESDDGKKSDSPSDDGGAFPTLSAATSASVKKQQAPEKMSRGRKGSKTHTDPDLAAALFRPARTRANSVDVEDNSACNSKSATQPSNTALHSAPPGNQFFKQQLDSCVEILLSMNHDLSEEAAREAGFIAKGDINIAQYVVDAAMTAKPVCRHMLHGGCYRSDCQFSHDVEGHTCLFWLRGRCGKGSTCRFLHGFNPKLVENIPSRSQAPQQVFSGDFGPLPAASTPTMDSSSASSHGMKANRTPTSVRTNLEASSFANIASKGYSQFKFASPTSVASPKAATPSALPTVRIPQDLWNPHENRDATFFHIPDPIERYTRVSASVKRRDVIDLHFQSTKTFSAVLARVLPNKLSELHEVWIVTGTGHHVGSKTHQKGGGALERAVTTWLVEEGYNCYRGRDRNGLGGALLVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1Q7</accession>
    <name>A0AAD2G1Q7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002019">
        <property type="protein sequence ID" value="CAJ1959770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1Q7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="445" mass="49810" checksum="7D616E679651C3DB" modified="2024-05-29" version="1">MTVLINSGGRMPGLREHETNEFPRKQPYRKQQKTLQSLLMDLDFAVSAEDKEDDDPFSAPNLTVLSSPSGCLCFCGKQVLNSYFARHLANSCPVANLKGVTRDDVKFKDDAKPKLMRAFICVPCGRLYLKRDSFSKHFKRNNSTKCRHERVNFERECMAYHTLHYIGPTPGASQLESGISGGGIYVDRVVQESAVDGLVQDQLPDDAILLCLGTNHAALKNELVDKMKLPSCLVEILLPLLVSTIGSKSPAIFVQAGIERVRESPDSPMAFISGADKWMRQYSARMVAMLPGSVRHEMLSFRVDTEYESIFTVRNKIKPVCSELKKIIHFTWKAFGLIHGFVDEWAPLQVPKYLYMLSLQNGENLIDGSPKLLQYTSFCFFKSSESLKGAYAIGSTLATILYICRLGSLGEAFKCNGNNYIGRQLALCKEVQQGRVIQTLLPLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G242</accession>
    <name>A0AAD2G242_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002037">
        <property type="protein sequence ID" value="CAJ1960032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G242"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="60649" checksum="D2319EE231FEB4B4" modified="2024-05-29" version="1">MSTSQLSRVLTQWSIGMAVSTPLVAILQGSLLLSNYRINYRDAPRPITPSSGVIVALAQQGAQARNRRGVPLTKADKPLRLLVVGDSLAAGVGVSGNGLPILPESIAKALSKAFRGRVVCWTCLGTPGISASQIVQDINSIPKREPRRLENLFQELKTKRDRWRQLQNMEMERLDYEESTKKQQSVLLKIIDWWKAEEKQPISEFGKEIAESGAKWWKTKSRRIQQTYSDIKEVIHAKPPGDIEKNLTAAKNSEGLLLREGNIFRRDSLDPFVASSFDVAVVLLGLNDLKEAFMPHITKGANSSFNEGAEPMDGALTKQLRSVFFSLEKIMGKMDNTQDHNDATLSTEGREKVNSSKDRLHPPLVVVPELPVAPLEAFRLVPLCWILLPLFRAMERNKKFLSSTFPDHVVFIDQPGLEWWSDAERRHNSYMEEDESVLRLTDTAQTAQARVKQLMQRFYNPNHHTVRSNEQRETGGGNGRSSLTNNFSEESYRYRRKSNGTLYIAQDKMHPNDEGYDLWGRHIAEAVVRHWSRPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2X6</accession>
    <name>A0AAD2G2X6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002075">
        <property type="protein sequence ID" value="CAJ1960851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2X6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="144" mass="16170" checksum="3E5571AD39E8329A" modified="2024-05-29" version="1">MQRAVVDRSGNGNSGTTDVTGSYVVRGRSVTNNRSNGRITGWNLAQVRVKPIVKKKVISTEDRGELLMQKWQAQLETANTLKDDDSMVSNGSVNMQIYKSTLKMDSLKHCSQWTKDNKKFSSQTEVNTRISILVLMPDLRSAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G336</accession>
    <name>A0AAD2G336_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002023">
        <property type="protein sequence ID" value="CAJ1959790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G336"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="336" mass="37989" checksum="8FE3A4988B28ECF5" modified="2024-05-29" version="1">MTEDDNASGLAQLYQRTRSAIADRTTHALIRLPPGTHLVSSDESGDDSTTGEQSQSELAARFSSYHSTNDLEGYEEDDFEPIPWSPHTSTQTSDVRADRSKDEASPSPMEPRSIQEMKRNPDDLNAFYNILPAFPKPRYQALYDYSSQFSLPALFYFTDISTFGMCWATFLIVGHTIQSLYTDFGPNTGILVLSPEISMLKHIFMDIMWTHSLLSAMMLVPDYFGSSSVMAAMIFASGQPLYLVICLKSHYHMKSQKVVPFVHGEWWIADVARLIFWGYLIAFLCICLGHYTDISNLKVTGVFFMNLTPLFACESYRLLLSLPARLEDQNGHKKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5Y8</accession>
    <name>A0AAD2G5Y8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5Y8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL/TRIO N-terminal" evidence="2">
        <location>
            <begin position="85"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6824" evidence="3">
        <location>
            <begin position="448"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1964106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="61085" checksum="C307FD68321A7A80" modified="2024-05-29" version="1">MNQNRSSSSPSSRLSSCNLLGRPKPTSQSSTLPITTCRHTRQEMKEAEDILASELTKLSLQERTEALHDIHCVGQDLKETPELVQELLAQFDQTVKQQQQHEQTYEMIEKSHQRAYIEDPSFRLKFLRSNKHNVDKAVSQMLHFLRNKIKYFGNGCIGREITFDDLNEEDRELLLSGIYHIQKDKDQSGRSVMYMLTELIGGDREESLCRVAYYVYFNILISIFEVQMKGLVFVFYDISKADELPVIPGLNLTMAIMDMITSLPIRFTAVHFCLKARPEKLDLFNSLFKLVFKLSSHDCKVRSRLHYGSDIELQYQLRSHGINTDSSPIDAEGSLREDNRNDWLHEHLDTERRSAIRSNPSGKKTPFVEPDVNAVTSYDSLISGSEATSFETLHHSVVQGAEESHVSNAAHGPTSESRVSSVVAGAHEKQQKSESNIENAPVTPTDGDIFLGRGHLIRCNPGNIRFRKLVAKYKGEYDIAPRRRRKEIISEVCSVLTSEGERFLKQIDTGVWVNCSDHEIQKKISMLFREFRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6F5</accession>
    <name>A0AAD2G6F5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6F5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1964642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="220" mass="25026" checksum="E3201D5737A48222" modified="2024-05-29" version="1" fragment="single">RDLVLKEARQLKKLAVDYLHPERPVVTTDPFACGRNYFTRPSAPLPEDEEIAAERDLVLKEARQLKKLAVDYLHPERPVVTTDPFACGRNYFTRPSAPLPEDEEIAAERDLVLKEARQLKKLAVDYLHPERPVVTTDPFACGRNYFTRPSAPQYDEDYEMERELIMDDAKHLKELAQEYLCREVPASSMFPTAEKVISPTATIASPSSDPACVLFVGMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G714</accession>
    <name>A0AAD2G714_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1963940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G714"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="187" mass="20894" checksum="4A40B868CA808EC4" modified="2024-05-29" version="1">MLSTPKKGTGTAGRMSKCIRRRSTRTLRDSAIKLSVENETGIYNEAAEPVVRSFGVPILRVYKASIPLHTQHYRVTDCTRFCFGDRGPYDHDRALMTKLIEEAIAGGSIGGSLPALPTERSEKNQFDLQIRWDLLMEHPTDSLMAKLNYCANSKKSTRPPSWKADKDGLSPALEQYLKNSEIVHRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G767</accession>
    <name>A0AAD2G767_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G767"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="120" mass="13023" checksum="096F10C59B9FB912" modified="2024-05-29" version="1">MQEDPEEEAGYYIAPARGRPNSYEAKPKPHYSVTYSFVTLNGQQVTATTTYCYNPVPPLGATETILYDPDSPTVGVTSEERKDGLKIGGTSMIVLGIISTGIIGVGLFFVSRQIKRDSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G839</accession>
    <name>A0AAD2G839_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002234">
        <property type="protein sequence ID" value="CAJ1965873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G839"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="343" mass="38997" checksum="248930583162B183" modified="2024-05-29" version="1">MDIYVALDSPVLPLRCEGDALLIEVFMELEVDQDALKWLNWCRMFLQVCTVSDIVTADGLSIRESMWHGERDYAHRSSYQWPRTVRPNRNHWKVWQEHLTRALLVSDGPQRLLRHPLGPWIDPLDNWNWLWSSTHGLFHRQGHGWQHYRHCRSSTRSIQWDYPRSTQLSGCKRPHNEHTANGVSFLPAPFWTQPLPADLCRATVHITPSLGTLALTGIGTAPLQPHHDSQPSLLAAWMAASARVTEYVGWTPEEIEIDGDESLLAEALLEDRLCVISDGSYKLGLGTAAVQLLPRKGGKERIIVRCQTPGLPDDQSAYRSELTDLLAGIMVVDWLLDQWVPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G848</accession>
    <name>A0AAD2G848_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G848"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="115"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="401" mass="46772" checksum="F6D4F4F8002C9880" modified="2024-05-29" version="1">MVNSTAAMSETQTKPPRLVAEIFDNKWSKAKEMGEKDDAPFMPTKPNVFTRTVTEETLEESPVKKSESDITDDDVMLDYADSRTEEEEEEDNYHAAGEQQHAHPSLDALLLMDVDNDRRRIHPNGEVVRIDNEWLDMEMLIMLRTPDVDVDDDDDNDYDESGTVDKVTPRNQMLSKHFKGKQRRFEFQYQGKLKKKPDDKSFCFCMELAELPKLNFLQKALVTTCMMFMKKMSPSFHFNMSSSGISDNDKTNGTYETPHMAFEVDKVLDRLAITKPGETPPVLGEGIPEDPERTKARRQGKYQVDWNTNDTYTMAIWSHYIDWIEWEVVHIPGVKHFSLNKVLGDQSIFMQLYLVDKNRKEKNKHYQKDIQHVVNLEFKENPDFVRLLDKKKRDKIKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G977</accession>
    <name>A0AAD2G977_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G977"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="395" mass="45055" checksum="B8C864B7848BC7D7" modified="2024-05-29" version="1">MAETRPRRQPSYDQHDDNEPDEFYRRRRRGILKPTRHSSRRFVPSSWAIWGVPIPVKTLLLGMVQMLLPVSMCWMGYTVEKLTFGDWILRVLVIFTLTLVSLLLLVDSTLSPSSAYQKSGCRIMITPAESKESVVPSSKAILSKNSSYQKIVSFAKGTKFFRLPRPKSKRQLLREKQELHQQQQQEQSQQSGNRSQTPIKFPTLAGMTPPPPRFASNEIDSTPDWKRAHRLLRQAMRDDPPAHKHDEREDLSSEGRQLDVRDEAQSAISKHLFGDNKSGSDGFDADSERDDDDTGDNLSVQGSMVERDDMEDLISESSSKLSKRTRSTILALEDDEDSMILFEDDDDTYEDTIMLGTHTCYSPLRASESEDTLEEELEEALVETIEQLSPNRLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9F5</accession>
    <name>A0AAD2G9F5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS21857</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9F5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042097963" description="sn-1-specific diacylglycerol lipase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="17">
        <location>
            <begin position="186"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1966274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="454" mass="49252" checksum="B3501F1ABE96EB0B" modified="2024-05-29" version="1">MPENLFYVLPIVAIALTAYGFSKKQGKDTEEAPPADSLGDVSLKIKTLLDSTKKKFGDKYSHVKLAVTLPALLQLIDQAEASRSSDTSSPRDESYNKAGKAATAKELDGLGGYLDFADWAYLPSRDEIKENLAGRGYKLLKHQEAKEAGQVGYFIATNPDTKTALIGVKGTSSMGDVLTDCCAAAVIRKLDRSFDSQDESLKEIRAHEGILYSSVALAEDLKPYITDFFLPLGYKILLCGHSLGAGAASLTSVLLRSQHPPLTKKDSIKVMAFASPPVLNHKAAEACSSFITTIVNNSDCIPRSSLNNVAILMELLSGVQEKLTEAGIDCKDMKSTAAFMAKLREGTGGAMIMTPEEGAALLQKSQTMVSRDDPDHLYVPGEVVLLYQKWQDKKKRNEAKDPEEKGEKKVSEPPSPAYSVITDGFTACLNMIEISNDMVGDHLCGAYRLKINNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9X0</accession>
    <name>A0AAD2G9X0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS22128</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002299">
        <property type="protein sequence ID" value="CAJ1966544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9X0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="103"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="206"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1966544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="294" mass="32369" checksum="EDDE4AFD560FAE49" modified="2024-05-29" version="1">MLLQILVRKLLRTTRSHPYFFCNKSRLNLILQQCLPTFGEVARYTGIVDCFTRVAKEQGVKAFWRGNFTNIVRYFPTQAFNFAFKDGIKAMFPKADKNTEFLKFFMINVASGGLAGAGSLMIVYPLDYARTRLASDVGGGKAQFDGLFDCIKKTVASSGIAGLYNGVGVSVFGIIPYRGTYFGLFDTLSGYNPYQKDESNVLRASSKFACAQSSAIAAGYVSYPFDTIRRRLQMQSEVPKEKWVYKGTVDCFKKIVADEGAAALFKGAGANALRTVGAALVLVLYSEITAAFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAG4</accession>
    <name>A0AAD2GAG4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAG4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="249" mass="28358" checksum="DDEEF00D56B720AB" modified="2024-05-29" version="1">MGAKPQLSPNERLARKRAAARMRQQRCRARKRQALLEQKRIQREQMSRSEAEPISTQHASSAFRMRRPTDGEVESALPTSTQQPIYKVVSFESQRSFEEANKGPSKSPVDTIVTVSSPPRKTADVTSITSADSSAATPVPDKEAAAIAAMLSLKSPPSEKKVRTPQRVEMRPREQQRPARSYGVPISAKVPLYKSYNNIRYEKARYAMPPQRVPHYYMGMSHPPPPPRPHPQYRYGYHPSAYHRYVRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAI7</accession>
    <name>A0AAD2GAI7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS22356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="1366"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="2608"/>
            <end position="2653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1729"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1998"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1729"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1751"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1816"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2026"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2051"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2069"/>
            <end position="2078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1966773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2663" mass="299878" checksum="197A0015DFAE058A" modified="2024-05-29" version="1">MTGNDANVNSIKPGKLLELAHFLTRFQKHYTTPNDDDNSDDEASDLILVKMEDLEAVTRYRRNFLKKESLNDRYYVAEEGSKSRNSTQAINRLQAKRLEKEIEVVNSKVSSSKRTKRIHHLLLRFEVWTTKVLAQKDFVTSCGALLEDTKKTKYSHFSPHLNIPCSDHFCNILPEVSQKEWSTPKLPSAMHHMPSASCTLPVTPNKHTWQEFAKISRMISILDETSRTEIYKSSSCIFDIKGRNSYKEIYNQQYEFQPLDLVALWVRAQRDSKANRHLNLLFEIQYGNQENASSKIKAVYKGNPFNTHRVCEASPKADQLVEWAVTNQVLFSYDQVRSHIQLACLKQKRKNRDEEERSQRKRKRQRRDGNSDEQDLDQLRQACCVFVLRWFGRRHRKLTSVLFSKKQNILHLDIGCREGDRNGANLLHEKVDEGIQNYLLKPEINGKVAFAKDKTLARIDRRIRNYGNQITLKSQVETLLDALYSAGKSHGVRLELKEAAKSDFRMLHRHFFEEPENALEAAAMLTNIEDESITSITNLLNGAPSPWQQHCAHCDYEGVENNPLRTCACCASPFHEGCTSWRGEPVSDIISSYPPLGALCTVQLPPTETLPNFRDNNAVKWTEMEILVERRLDDIGWLEMSLGLSMAPTESCYDSFKNLTDGTILDLAKMIAADKSNQRPSFPMALTVNGSLIYDVANGNCVGNRAGLRKGDVVQHLQIVELFDRADISSLPPQRSFDFQSISNDDRINAFKIPAKKIKVHIVRPSIDIVESSHDWYEQVKVRNKARTAAMSEIHSGDICSKLWQCGNCQCQFTQEKQTPRSVKEEAEFCRAVIRRIGMESYAHSFEAERTAGNDNCPAVSLRRLDAMMTHIVNRHSVAGKSGESSARSFLNPPWVVEGGSHLAWTAGLEERPMELLCKGVGTISESASLGNGGSRNAADVTAMFRHFLIAFSSWCVLPCKGNRRTRGPPPLFRSMLPPWILPSCTICSGRPVAAGNAKVCNNPACSTLARSNYFQMDDFPDEEVATLARTIEMYESRSSLVGTTFLVHHDDPLVKAVSKVVNIEHNRRPVEFVIASYLPKEFRDTVLNGNQIWEGDKCSDDDGIFHLLPVISATQIDFLLDRLKTRKKPAVSDSTGDASWASLEALNVPGVARYSFSDVERKRFESAKIRIAMEGAVVRKCMLPPKTTGACNEIIEEPSRFELIDFVVSQLEPLNSVAYGSCLTSAASHLLSQDEFQPGVETVTYRSKSTPRSNWPIAARAGNGTRTRQDVFGETLLLPRLRSIVCAPELKYDVLIPKQDDCVLVYSDLHFESDEDCARLKRQLQPEVLNKPRELNLSSRSFSGRSKTILLLKLDSEIDSGCQGVGWGFELVRWEHEEALRVGRIRSLSPAQRAGLQTDDVITSVGGRKINSFDQVNLISTILGASNVCVRTEDSLVEPEGIISTVLGNIVETCNLDPVVLKVYRPSQESDESLARDSSNLQLVAQRHQTLQSIELDSTKNPIHCADDEVLVLGTINHSTQPPNQLQVVSRDRSQNATVLQDTSRHQLASGVATTARVPKAPKNQTFDRTKAFSALYIRLHTHHGRRPVLSTDHLYFPAKNGVILTLGETALLLECFKRQQPKLGIRLLCPRYNPALVRNQFKIMATWTSQVIQIMPKLTDQMFASFMALDWRRAINKENPEIGEVVFREANPDATSSDDAFWTYRYPVDRLPVDRCLERLLASAQQTQSQQMHYQQQFHHHENQPPPHQQGQSQQIHYQQQFQHHENQSFPHQQAQSQQMQYQQHFQHHENQSPTQYGSPPSGMEPSLQYGPQPNGPPHYDPPPDPLKQLPYYGPQRNPLEPPPHYDPQLFEPPTQNRPPQVAYRPNESNQATHMNGERIRGGGTSIDDEVGRTRLSEIPVKQWNGLPVYMLVQTEESKENKMLVGFVNPEPDVKLVAEMTIDVECHFLEDIGEFVDAVMHKEASNEIFVIDMTANDGYSATASSVIRELYAKGKGPAKNRLNHTDTNAGTELQDGGDQKLSIDANNSNTNHDGLSPKNTAAAAATDSPEIQSAPGSNLLNQAETAVTEHESRQETPCDTSCNSTLDREVPRQSSSLPPPNKTKGQMNYLGDFPDGRNCFWIVNDPEALYITIDQLNDSTATRICQQQYSFFLDTELSSASSSSNRLVMRNSDRYHCPWGCFLAKDKNNEAEHRETLSFTSKEDLVDHYKYCFSYGDLSGFFDVGVRSRCVRISDGQKIRDLYCDLSSALYVRSQIFDFFTKSGELPTKTSKSGTRFSQSPTGRRIFLVIDDKFSSKIEQVQDTLSVHESAIVCGLARLMESISSRFEVRTTGNLRFDDHELLKYCSVEETRSLVSVNVDERERLQEKKRLSSDTLCSNCIGCDLCTLPWEKTVKCLEPNTTDAESEHCFGSGCCLINTLIRSSGMRKALPGSLGEAKVLILEIGDIVPEQLKVREPRRNFDPLFGCRLWDENNHDVWKRFVTEATCAGQLSQAYVTLLASIQKELLPGWWRTDGAGWSTPHVILVNGKLSSLLLHVYILDAAIAEYRCQKLYSKNTGPSSNSILMAAQRPKPRKVTGTATERMKKYMDLALKQGYELNKGANGSECCICDDGGNLLCCDLCPKVQHAACCEPRIEGNPNTLDTFICNVCINDIEESMEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAI9</accession>
    <name>A0AAD2GAI9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thymus-specific serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS21472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAI9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042247076" description="Thymus-specific serine protease" evidence="6">
        <location>
            <begin position="25"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1965883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="60140" checksum="7BEEAF8607DED3D1" modified="2024-05-29" version="1">MIRTAIHLLVPWAILLQLFGTVHATVSSDYRYTYLNVLRKTHLDHVDSHDKNDVEETFLNQRLDHFDRTNRATFEQRYFSTDRYVLENPSKNVNFLCVGGEGPGFDKSVLIDSVHCTGDMLELAQIMSKKHGVSVQVYALEHRYYGKSYPSFSDSPVTIQNLKYLSSRQALEDLAHFVHHINDKQGRETRWVTFGGSYPGVLAAYARFKYPHMIFAGVSSSAPVKIVVDFPDYYHVVGKDLRYSKVGGSPSCYDIVKKGHEQATQLVDHEKFATDFMVCDASKLKERRNQEILLGDGLINIPSQSNDPGCTDDLCNIRRLCDFMEEIHSATNLTELDVLATVASKQRRSDECLEVDWNKTLVELSKPVVTGEGWRSWLWQTCTEFGFYQTCEDEQCPYASSYHRVDIDLEICKVAFNVTDVYENIEASINYYGGLDVNGGSRVLFINGDVDPWSALGLLNSTDHELPAIVVPGASHHAWTHSKQATDSTEIQHARAMIYATVTGWLTDERSTEGKRVVGTVGSLRMNNVVSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAU2</accession>
    <name>A0AAD2GAU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS22523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAU2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1966937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="290" mass="32784" checksum="8C6E28981584D3B3" modified="2024-05-29" version="1">MTIKDDSSQLSETPALGGTPVNKEITTTDDVEGQKVTKRKKGNAQHQESSDPREQKLMHWRNSIYAVGRVNIDWKDENPFLSHPPGHKRNDNVAWSGVVCGSCLTCVGRIGNMAVFYSTMEEYEAVEKSEGREDRVVKRKRPRPVCMVGPYWPVNLCLTWPLILGISGWTLFTKVIYQNFVIIITWSLCTFALCASLLLVSCTNPGILYRHEEAPPGEEGSWQWNDQARTYRPSNARFDTECQVVIEEFDHTCPWTGTGIGGGNMKHFKSFVFMVPVCIIYTVVLHMGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBT7</accession>
    <name>A0AAD2GBT7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS23584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBT7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="830"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="39"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="476"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1969196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="861" mass="95387" checksum="EEC67CDC7E3EE5ED" modified="2024-05-29" version="1">MVTIQRPGGTEQKKRISGLKGFTFNPDFAVDEDLKVQQNIKVAVRIRPLSTVSESSPNNDNEKSKEKTAWALEKSGAMDTLVQKGMTLKVDGKSVFRFDSVFDEETQTPLVYKSMARGMVKTVLAGKHATLFAYGQTGSGKTFTMQGDGKRSGGQAGIIQLVTSDLFRFMKQGKSTDREFVVKVSYIEIYNETIRDLLSDDAGSTQSHGSAPPPKRGRRGSHLDRVNIRATASGEVVINSIQNEVKSADEVLEYLIAGNAQRKVAKTDMNKHSSRSHAVFRLTVESRPKEPGEGGVEEIVRISDFNLVDLAGSESVKMSGTTGIRKREGANINQSLLSLSTVIHSLSMPEKKRPKHINYRDSKLTRMLQPHLSGNAEIAIVCCISPSKAYAEETRTTLRFAYRAKLIRVTPKVNEILDDGAKIKKLERELAKAKKMIEELRGQPSSPLGFSSSQASEPLQNGSADKIRSASINTLQSGSVDDSLQTESVNTLPSRSRSGSHDSDENSHALSVADYGYDEMAQTRNYVMPGQSPIPVPPESSDGNENNSQLKEYTMPLKSSYDSDDESQYEELLPRDDFKLDAVGEVEARKCVQKFMKGKDYGDSSTEGDVMFDASWDEDSQDSLPYLDVGVKKESTNATTRTDDESSSYDGPPASYKDASFKFGTKLSRPDTLGVDTIPENESKYGTHDGQDGRTNEISWDTMGLDANRPEHVGQPLRALKSLAEQDLPIPKEVTIICASSVDEEPGLKEKNEDAVKQVAFLKAKLEGADDIIESVFKDLERARLCIHDMVHRNVQLVGKLNDKRRQDVKEEYEEGEINVEQYWLLKGSMYVGLFFFFTGGYELFMASVIFIWLMLEANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBV1</accession>
    <name>A0AAD2GBV1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002404">
        <property type="protein sequence ID" value="CAJ1968788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBV1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="133" mass="14152" checksum="B1432FA8B7A84119" modified="2024-05-29" version="1">MKDNIVNPPEKDPNLIMTVADQGQGGLEAKTRSNLTTQSSIALTKDNPAITTPKRSSKRNPSETAEDGAMKGRSLFPSAVPQVQDVAVNTRPNPTTPLSIELTKDNPPDPTTSKSQRKHPPPSKTAEDGAVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCS0</accession>
    <name>A0AAD2GCS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAG-pre-integrase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="264" mass="29133" checksum="D182BA8EB2166417" modified="2024-05-29" version="1">MLGDEKTTRYPIIWDSGATTLISPYKDNFVGKLEPAPLGLKLHGIASGLEIKGIGHLHAQLLSTSSLLQTYTDESISMNADHLQLSGSDKTNSVHVYHDPSTNLPTSLAYSHGTAPNRFDAFASIITSTLESDHNLSPVEKELLRWHPRLGHLNFSQIQFLLRTGVLAHSESARRLQAAASRITTYPLCPACQLGKQRRRPSPGKTSRVVCDREGALKKENLFPGQKVPVDHSECTTRGRLLHTFGKEDPKTQYTGGCNRLCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDV6</accession>
    <name>A0AAD2GDV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-oxoacyl-ACP reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002524">
        <property type="protein sequence ID" value="CAJ1970478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006393">
        <property type="entry name" value="PRK08642.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27552" checksum="B4710E421CA4AE3C" modified="2024-05-29" version="1">MPLLDNKVALITGASRGLGAEIARIYAREGATVWVNYFQSEEKANAVVEEIKQAGGKAMAVQADVTDEEQVNSMMTTIIEKSSRLDIIVNNALPTYKFDATAPYTSIETISWENMDQQITGAIKGAINTTKAALSTFKTQSYGKIINVSTNLIYNPVVTYYDYTTAKAGLLGLTRNLATELGQYGVRVNILAGGLLETTDASSATSPEIFQAIATTTPLRKTTTTQDFAKASVFFASEMSDAITGQSISIDGGLTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGQ4</accession>
    <name>A0AAD2JGQ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001737">
        <property type="protein sequence ID" value="CAJ1948020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="73" mass="8310" checksum="60044E75CA4FCAF3" modified="2024-05-29" version="1" fragment="single">MTITDFTVRKKSYRYLTTQASYPNHDSKAVLDAFDPTKDLQLQDLNSLVEKGVQGGAPAWYTGWPKEQVNNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHR4</accession>
    <name>A0AAD2JHR4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1646"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1774"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="934"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1647"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1667"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1777"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1879"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1912"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1953"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1998"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2046"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2071"/>
            <end position="2080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2080" mass="223007" checksum="571637C6AD5F04F8" modified="2024-05-29" version="1">MVTRRSRRAQKKPPEVVPPKSDEEQPDAEAGDDNTGESDEESDDKTNTTETSSRPRRRQKGRKPRGSGESENEDNSSDEGKSKENTDSGASSDDEPLSAKANAKRTRQQKKPAETDGEGKKTPNRRGRQRKNVEEESNAEDGSDAEKETIRKSRRRNAGRRKQQDPSSASEDGSAKKRTRRRGRPKKSQDAEDSDSKMETAEEDGGSSEEESTNKPTRRRGRLRKNQDTEDDNSKMESAEEESAIAEESTKKTARRRGRRRKNQDTEDDDSKVESAEDDGGSSEGGSTKKITRRRGRLRKNQETEDSDSKIETAEEDVGTSEEESTKKPARRRGRPTKTEDTDSKMETAEEGGGSSEDESTKRPRPRRGQQKKKQDVEESDSKMESTEGGGGSSEDESTKKPRRRRGQQKKNKDVEESDSKVGAAEEDGGSSDVENKRKPTGNDEATSRPARRRGRTRKSSESTSSNDEGEEETQPKDAENKASKLDTAADPVSNDVQTRDKEAQPKSGRPGRPQSGSAHEKGSSEAREPSSRKRGRTPPVPSSDDEPNGSNQPTRVSKRRLERVDETFAAAIDSATPSDEKNANEDSAETSSEKPTTQEEASTEAAAKDKNEDGGSSSKPEPKQEKQEATSTEAAAMDKNGGGPSSRPEPKQEKQQTENDSTTETSTRRPKRLRGSTEQPAETAATKIIYDAEKNEKEDKDCELETQGKKRSRTDVNESTNNARDSAGDSVAKQVEPISTKAEANSSPKTAEEKDSEKEKSESSKSTQDHNDVDPGTKVRVTEAKDPSEAATRSDIPDASEKKTFPEGEKTEVIVPTASSGSKDIGDDKKADLSTKMGPLVTKPLPTKVNPLVTKPLPTKANPLVTDPTARPSSESYEVVSHGNASSEKKAQKSDQSECQVSVEHNQSKAIADNDGPTLSLEPPTTKMEANDSPKVQPSSPVSASVQPSTSDDKKPTAGFSDPAMTPSEKTDKSENQNGNRASDDMDVDSPVKDVTMAGVKKKTPTPGMAVAVETSHGKESQPKPSEIAPSIPRPKAVQTVVPGEKEEEKRSSCDAELPVIASAAKSMSNETMVIPTDTSTPREESNAGATDSNEPVASDNISECVDSSPVTESSSEDDDESDGEDDRPEPRFETKAMPFTSSTLLPNANKQQNSLELLGNKVDRVKTMLYTIGSRVHRGHGFERIFAKYWDALTMRLSDRLSSYASRQCNAAVKAFLKSPKLRRIHNKLVVTLMKTSMKSFAPLNEISDHIPEVWYGKVKQVDRVLVEDGVKETKRQRKAREKRSARKQTTVYREAWASTQGTEENSTSAIYLKTRSQEVDMRKIYASSATIPGALVIDPLVRDIAEQSNMRASENAIWLLIIAAREHTSNVLKNALQHKADMECGEVSEPFLQYPNVIAGTKIAPKKDTPAETTEQQPTAPVDFRPGKSQKRKVVTSFDIYSSSLAVPAGPPASLGGSVSTTALELGLQNAYTSSTSCPGTDFSDVQKHIVERITSLAQDRKAMLLARGEEAKSNQMNLVTSQQQAVNNGQNVVSNNSVVSNPQVGVGATSAVGTPAVSLNAPARGQARQYQNSIPTTKPKPALAVQMQQGKIETIPSSTPTNVAAASLNTPAIAREAKPVATIPGRLGRGAKDLAALIKRSSAEPAPAPTAAPVSNDKVRVATESTTVPPANPHTQKPAEGSGTDELGTSTGSGRRGLGFGRKNLSAMISRTPKPGDDNNAPKPGEDKAAQATVVLKEQQKQIPKTGTRPTGAKDLRAIRGAAGSKDLAALKARSEARVSSEAVKTTEETEQKKEAGPQGAAIDPKSAQKVPETSTEADTPIAASVPPKPSNSTQNKADSSIAPRPANAAKTDSTKAPSPADNKNAGAPDSNDTNSRDRDTKGGESDDSSVVVIESVKPAPKAGNKDAFSSSEGNKTVASIGQPNGHKVEVKDANAPRNTQPRPVIAPEKPEESKSAKKSLVEKESKVAKDAPVTSEAKATSEAKGDAVGGQSTASPPTAATTTVPAALADAATPKTGESDPASASKSDENKPMKGSTVKPDGTKADETARAKAQEIKVDSSNASAKTDEKAEHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHZ7</accession>
    <name>A0AAD2JHZ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS13120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001786">
        <property type="protein sequence ID" value="CAJ1951539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="9">
        <location>
            <begin position="1659"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="8">
        <location>
            <begin position="1901"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="261"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1951539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2132" mass="234725" checksum="2C78514F63FE13CE" modified="2024-05-29" version="1">MDRRRKISQTSGGNRGSAPGYEKPVHRPLSNPTTLPRLESRGISVGGVPLSSPTECNRATSTGPTMSSYSSTPNHGSPPSRMNSASPIYANHNPSASPNVTSRKCRPSSSMQFTSQENPILADDDPVDRQPSGSRTDRSPGPARIRSTKSPKRKAKSRPDRKSSESRAQNGDVETTRLDTPAASASVGSGSIGNTSVGDTSIGMAASASAGVAASASTVAGSRAGTAISSNDVTDAHRDSQDLLAAARGNEVDGDYIRHMLEVCKKDQEKLQVKLNNALENPDGMQNLEQLFTVNDELISAVNAGKEALKKEKKKKQKQKVLDGPTIELLVQNEDVFSLICMLRAPTEKRLSAALALMRFAKDNDALRNEIRSSGGMHSFLTLYRGRSTNRDLRVVASLAVAYVLPSFVVKSQVTSPMTMKFLECLRFLVTSPPASPQEVSISRQEMYRAASAGVNALWTNTIGPLIALEKSKQVTRVDMATLEKQISGFRRFRARSGGGVFDQGQELKEVQDMTELAVTLIAHIAKAANQEGVQTAYGIVEQICAEDMARPIAVREGLLSTLVEWIRSKDLSQMRSSASALRYLISIEDKYNAGWIHSQVVNEGAVSEIVKLFNESVGNDVREAIAEMISALCQTPPTRAAVVESNCVIYLVSLLYEHSSPSSENMVHYAASALLQLAAGGIMQAGTSTLSKRGSSVMDRQETVLNEMIEGWAHGSFVQIALEHQGRLRSVSVEAIRVLSEDTNRGRQTRLQLCNANAAEALGKTLKDSLGDLLPLAETSGFGQEFRDPEGPLFTAAKDVHASLRALSNILEPSQKRPSSKYSQSQAINPKEMLIKGCMGLVQSEGMDPLIWISSLPLTPSPLSQSGVFMPDREDLVAEACKSLANLSPLLLSDLASSSGSAKWAISVFESLDRMLDAGGEEDSNTTHQELSSDLWIDALKGIGALAEYEPLKIKIVDQTIAKLLQLKTLSGDTGDVSNAANQVLLSLGFTEDEIAVQAAGNDPRLLVDWFCLHRGIVIQAMARDEIRAQVADMWTSPLEDSDVKLSLSNLQRNESNSWSVGREDQLFENFTSDRDSMSYRETLLQQYHYVYQHELIRLENNYGIDHVIDDSKDKRSLLSSHVFPLNHAMVERDWVLSHRQRVLSNDERRFSSSPYLPERVEKLLDSCFPCVLLRNEIIPMQDFSPEASFDFRALMMPQRQYFSFRREGQLLARLCEKQAAVIDSVDVHWTLCFTNSTFAGEFVESLVQTLYLCPMITGLSFSKKSSLLGIGRDTHSDDEIGSGLLANLAGSLPPWVSFLTFDNTLGDKDLRSLVSILDTMGKLSLDSNIGGSTQNNQSQGKYTCMSIRNTPHISRETWGIFFNLLGKTGPSTRGPVSMPLASLKVLDLSGNKLGDEACALVLELLHEKDSGCSVEKLDLSGNKIGRGANVVRVLKSYIEYYRYDQLQGTTTRNSWKSSLHTLNLAENDLFLGQVALEIFGLAQNNALSLKYLDLSNNGLEGDPYQIIAGSLPKNTALSHLNLSGNKFSAPLIDYIFHHLSDVEVDSGLSFLQLQNNRPLLTRSQQDTLDKFLRKSRKNAIERRVKGQETGQNEVAAIPEFGLDEVDTGDNMITVLFSAPLVFADDENYLHPFAKLDFDMERELLWQCMKEASRDIELSFDNAHHSRLLATLTKRCSCLHYSGHGHPSNFLPFEDGMGGPNWLNVQDIEDLIVRDGVAPFKFVFVSACHSGLAGETFASAGVPHVVCCRQESELKDTAALAFTRSFYLALAVGQTVKESFEQGCKAVRATPNLKDPEKEMEKFVLLPKDGNHNVPVFRARRVPQWPKQIGTKAKNKRGSWLLSSRNQRSSIAITGGTKNSELSVRNMIQEDPAPSAPNCFLGREVDMYYVLTAILKMRKRLVSVLGEPGIGRSSLVCALCHYINERASTVTEVQHIYFIRPKHGGRNVTCRSLLRQLMDKLEESGKSAPIDQDADLETMLDAVCKSLKNDKALIVFDRTELLDQDDSEELPMILSSLLYDTKQVKILLTSKHSLGQPSIGGQVEHPHQLGPLNFENTVRLFSNLCPHLYTPSERNQLRKKLVVGNEYADCFPGDDWIDESTKSIFRLLGNGIPAKIEKAAYTISQKDLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI94</accession>
    <name>A0AAD2JI94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001828">
        <property type="protein sequence ID" value="CAJ1953526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1440" mass="163127" checksum="86779F8AAFB72D01" modified="2024-05-29" version="1">MPGRRNQGRGGRGGRGGRSAQQTGRGSHGKKADRPKQYHPHNPDFTHEQVTIYLLEAIALKSLDYAQDMIWSVRNMAHVDFEALRGTQTVYKPGKNDSEFFKSSRQAQLDRNWENLNVKAQADQVFEILGTDVLHANSSAPNGVSNAQAAARTTSSRPAFSCWCCGDTGHGVTCCPKRSTRPQAEWSDPGRYSDASTTTTTTTRRAGRANLQVPATASAAQSDVASSVTGTQSTGQQHRSNMQRAVVDRSGNSTSGATDVPGSYVVQGRSVDDGQSNGRITGWNLAQVRVRPILKKKAVSTEDRGELLMKKWQAQLEAASTFKDDDSMVSDGSLNTQIYKSTSKMDSLKHCSQWTKDNKKPFKSNGSKHWDIDLGVHLDSGSTFSLRMNEDYAKPGTVSDLDYMFNYGTNTGQRDLHQQVESSIIEGHTCLLDTEAQCNLDSLSELVKLGFRVVMDTDIENSFIVTKGEQRMRYVHQNGLYTFVPDGRAESDEGSEYSECEYRECGNGDCDAIGVAHTECHKCGVIFCCRLLKTSYSDSDYCGIQTVRENIEGFTDKQVERANRAQSVYHMAGAPGVQAFCIAVRSGLFRNCNVNEEDAIIAEKIYGPGSSVLKGKTKRPTPEGVRDDWIEIPKELLMHNLSVVLHIDLNNSFGLTTIDGSVRHRCCIPLASRSKTALYDTIDKCFRIYNARDFTMEKIYCDGEFRPVFEPVKDELEVHMNYASRGKHDPKAERNNQHLKALFWVHFHRMPFKAIPKKLTVALMTRVAKISNYYPAKGGLSAYYSPHMIMHQRMVDASNKFVAEIGAYVHGYGHDTKNNMAARTIEGVYMGPTDDIQERHRIYDLNTKCEARRAKIKVLSMTDQVIKIVEEDARLEGVTELRTYSKRNGKLILDGDLLEGVDPDELWDENYVPVNEIERLSDVTLRNENIPDDELEELLMDAEADIMEARFDRDRNPRYDSEANQYEDELEDEMLDRMFKKIKAKQDAEDLMDKDYQEHEWITANEDMDYKDEYESELDDEESKQMLDKLAAELVELGKPDKEEVLFEFDDNTQEDVEVESEEEDGVARAGVRFADTDDDESNTEGIVRSYSDDGVEVGAKRVLRTRHNQSYFSQGVKMRPTERYRREKSRFGQAYLQKRNPPVPNVLRNRRAMRRKARMERLRVSLYQAIKKRIDTQRNGAQLQGNLKHERSIRERVHNLAFQQVGNTNKGEYDADEALVVARVIQQIREGVNGAINGQDGVSFIQQYYLNKGLKIFKEQGKDAAMKELDQLIKRSCWTPISIEKLKPTERKKAVDAMMLLAEKNDGVTIKGRCVFKGNETRDWLSREDTASPTASHEALICTGVIDAHEGRNVMSMDIPNAFIQTLMPEQEEGEDRVIMKITGLLVDYMIDLDPTYRDFGVIENGRRVIYVVILRAIYGMLQALLLWYRNLRASLEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIF5</accession>
    <name>A0AAD2JIF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF46">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="572" mass="62580" checksum="ED9E2CC0BFDA1756" modified="2024-05-29" version="1">MMSDDDEVVEESSSTATEAPKVPKKKIAVVGGGWGGWGAAKALCQSREDIEVTLLDALPDPTGLTPYLSKSGKPVEAGTRGFWKDYPNINSMCAELGIEESDVFTPYTNSSFYSPDGLEATAPVFSETKFPTTQLPFLSSFSGQAVPQLPSPLGQVLATFPLFERIPLSDRASMVGLLLATVDCLGNDVSVQEKYDRMTAHDLFIRFGLSERLVEDFIKPTLLVGLFKPPEELSALVVMELLYYYALAHQDSFDVRWIANGTVADSLIAPLATSLQDNYNLEVLGGARVEKISLDEDGMTSIEYSRGIVGSLGGTQSMKVDGVVLALNGKGMASVIESSPDLSQYPTFSKAASMKNGIDVISVRIWLDRYVPTRTPANVFSRFEALRGAGGTFFMLDQFQKDAEESLWGGDEVQGSVLACDFYNAGSLMSLSEDRIIDILMKDLLPEAVPEFRNAKVVDSWVGKYPGAVSYFSPGSFDRRPPMQGDPDVPQIKFAGDWVRMGDQEHGAKGLCQERAYVSGLQAANLVLDQVCGKSRLYKHPVIPVRDDEAQFKAGIELNKQVMKVLPRFWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIH4</accession>
    <name>A0AAD2JIH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS14032</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="919"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="963"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1009"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1953432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1262" mass="142704" checksum="21A94CA96D459204" modified="2024-05-29" version="1">MDSQNEEEEYIAVDDVADDSDEEHECRVCRGSAEEGRQLIKPCKCSGSIGLVHQDCLVSWLEVTRGDGRCELCKTKFRFDPQYADNTPDRLPAHEVILGLTSRALAKWLPFGLRISIALFVWLIVAPMLTSCLYHGWMHRPSSVLTRWKRDTIPSDIVSGAIIAAVVIISFLSLMSFADFLRVHWQQGPRRRPGLGEEEEVDGNGADNTEDENGIDETIVEIARSHDFARETMQGADEKYDSDAEGPKKKPLDHQDSMENKVATLDELHLGADKDGDDEVYPPDLDYDDIINNPPRVRDLVEDNIFRLVHEMDERMDDPGIEEEEQDPDIWPQEEDPQEDGFAQVDPAALQDDQVDMEINVALDELLGLRGPFSTLIRNLLWLLAFNATYLGIFSFVPKAVGSTVYSGLFNNTVCDNILKKIPYVYSDNENATTVSYIIRELNEESADKETTFRLPDIVTVTLGYFSIAAVVVMFRYFWIFLLQLQQKKSEDETAPLQPPAGLGEARHGRHGAQRDEVDENGTTLEVALDATVAVVKVGVLLFLKMFLLPLSLGLCLDVSTMPLFGHSLARRIEFAGADIFSFILLHWVAGITFMLLVTVFLLQLREVAHPDLLAAVIRPQEPQPDLLGNLMHETVLTHMKRMFLSLGIYAPLLTLHVYVPIRMIHWIGLGDFLAFYHLNFWHIVMPQLQIPIELVIFHLSMLALLERYKNSIGGWQHTWMVMMCKHMGLTEYVLPRAVDKFQLAGTKRVFLSNEESEYNVDPFWYELASKEKNIDYFVESNIEIADAAQDSLVGDAKANGIRVLDSSLGFIKMPETAGCDDSNSRCLLPTKRGSYCLKKSTIGSSTSVRIEFWKEIPGDTIPRPPEGWDDLGAGGAYVQGRWAWGKERKSVVEGSVAHRKTFRVSEQHRRPLFLMLKVVGFFIFSWIAITCTVFGLTTAPLAVGRSFYYLFRIPEKYIHDPFAFVMGAFVFFPCTSVVVNAMKKAEGSSISTWREWFSKLYLPPLRKISVLLESALLWAAVAPFALGLTYELVAVKSSKWFMMEDPLIDVKTAFMSWFLGFVVLNIWAFESYNSFFTEDFWANFWNAIVEPADDNAVREARNNVNAGNEASGKGSWQGKTGRVAQFFSVWRSVVFDWEWEYVDQVALLDEFSRPIARQVASALVGSTICWQIIIQIAPSVLQAGNGGFMVPLFGQVEYGIFRMGIFRLCAVGHVGVQLCTAHRRRIEQWFRVAHDAARDDRYLVGEILMAYDSSTTIDIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ37</accession>
    <name>A0AAD2JJ37_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TIGR00297 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS15063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00297">
        <property type="entry name" value="TIGR00297 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042290408" description="TIGR00297 family protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1954470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="34345" checksum="FDD9995D8D9B0AC0" modified="2024-05-29" version="1">MKLSTLLIAYVALPATAFVSSRPRLHKTTLNPQRRRPHDGNAFDPIPASSLSKRRLSTSSIVETASFIGNSLLNSTGHVPFSQALTLNVFLFTTLRSKLLKVLTPQGMLHACALGSGLWATLGWKGWTLCVAYLFFGSAVTKVKFAEKEQRGIAEGRGGRRGPENVWGSAATGLMCAICAAQGDSFLGISSDLFILGFVASLATKLSDTFASEIGKAYGKTTFLITTLERVEPGTEGAISAEGTAASVVGGLLVSLYGWSIGLINIEAIPISVFAAFAATNVESVLGATLQGKKNLEWITNEVVNFINTLVGGVIAIAIGGTFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJC3</accession>
    <name>A0AAD2JJC3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001894">
        <property type="protein sequence ID" value="CAJ1955789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="408" mass="44875" checksum="619F716C2CB511FD" modified="2024-05-29" version="1">MIWSVRNMAHVDFEALRGTQTVYKPGKNDSEFFKSSRQAQLDRNWENLNVKAQADQVFEILGTDVLHANSSAPNGVSNAQAAARTTSSRPAFSCWCCGDTGHGVTCCPKRSTRPQAEWSDPGRYSDASTTTTTTTRRAGRANLQVPATASAAQSDVASSVTGTQSTGQQHRSNMQRAVVDRSGNSTSGATDVPGSYVVQGRSVDDGQSNGRITGWNLAQVRVRPILKKKAVSTEDRGELLMKKWQAQLEAASTFKDDDSMVSDGSLNTQIYKSTSKMDSLKHCSQWTKDNKKPFKSNGSKHWDIDLGVHLDSGSTFSLQMNKDYAKPGNVSDLDYMFNYGTNTGQRDLHQQVESSIIEGHTCLLDTEAQCNLDSLSELVKLGFRVVMDTDIENSFIVTKGEQRMRYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKQ4</accession>
    <name>A0AAD2JKQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS17530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="536"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="798"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="723"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="740"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1959106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1185" mass="132831" checksum="58F43599D92FE1CE" modified="2024-05-29" version="1">MMKDSKSISSRSQMESDSNSVELSIGNGTMYETVTIFENSSNDGTASIDLPEETRKVTRREDTFIGRVRLLVVFVLVVAVTSVAIVAFLLVTEQEQEEFENEFNGHASEAAAIVSQNIEKLFQALDSASVMISSEASAQNETWPFVTIDHWSMKADRIFKLGGIGQSTLALAPIVQQQIVNDWTTYVEQQAPVWYEGSINLEDSNKTVDELVSKTIPYVHTYANNSFVATPVERNGPVVPIWQSHPLRMGKISPSMEALPTNYDILQGLGRGMPLIEAVNATLRPVISLSYVGVNESTRENIARSTIMQPIFEEVEEVDIEGKDAKLVAVLWWQIDWSVVFSNLLEQDVTGIIAVLRSSCQSGSSQEHTSEVTYRINGQRAIFLANEDIHSEKFDKMEISQVLADLGSGKANLQSQICVPKVTLHLYPTNDFQKTFVTQEALYYAAVVVFIFCFTSVVFIIYDFLVSQRQRIVMDRIMRQEKIVSDVFPSAIRDRLYNGNIDDGQNPNQDDLLNADFGTSHMIGSAPLADLFPNTSVIFADIVGFTAWSSQREPSQVFVLLETIYNAFDKIAYRHGVFKVETVGDCYVAAAGLPEPNEEHAVVACRFARSCLKKMKDITLKLEMSLGPDTADLAMRIGIHSGQVTAGVLRGERSRFQLFGDTMNTAARMEHTGERNRIQVTEATAALLKEAGLGRWVFPRSTTIFVKGKGNMQTYWMKTLRANKGRKKSRPKNEIISVEDTAKTEETAKTEETSEETSDTRSEGSRSDPSDTEGEDDLDYDIDGVEEMTKIDRLVEWNVENLSTLLQQIIASRGGVVQSIDGLKEAEAKVGGNGTVLEEFIPIIHLKRFEEDELRNRLRPTEVDIGEAARTQLRSLLSGIASLYQNNPFHNYEHASHVTASVQKLLSRIVKVGEGNGLESNSPDQALDLVDLAGHSYGITSDPLTQFAVVFSAIIHDADHPGVPNSQLVKENARSAQIYKNKSVAEQNSVDLAWEIFMQDEYKDLRACIYQTEEDLHRFRQLVVNTVMATDIVDKELQALRKKRWDAAFSGTFLYEPSSISVDRKATIVIEHLIQASDVSHTMQHWHIYKTWNEKFFMECYGAFKAGRADVDPSINWYTGEIGFFDFYVIPLAKKLDDCGVFGVSSEEYLNYAKTNREEWVREGENIVKGFLEKFEEKMAKKEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKT6</accession>
    <name>A0AAD2JKT6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS18123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="313"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1959704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="628" mass="70636" checksum="84BE6542B91E165A" modified="2024-05-29" version="1">MDKHEDPYEILGVERDADESTIKKAYFKLARLYHPDKQETEEEKQRVNSKFAKISDAYGLLNDPGRLHDWKQGNGGRPSRSSGQSRPRTRSNSPKKQHQRAQRRHSGKRAPASLSPRRQSFGPIPQRKTPNPRTPPPGDVPRHVRTAKRSVSPVPPRVNSPTQQRNSPQRNSSTGKQQQSRNRKGLSPSAHRNRRPTSPLPPRNSPGAYRQSSSPGALRRKTYNSKSPATTTTTTTTIPTNKVRRPSLRGPNPLPSPPSSPPAVKRASFVASPQMNPHAAFHQSWPSSQSPPSDPITTVESAKDIEDEEKPKNPFQILELHWSADKVEVISAYRELAQKYHVSKTYATEQERQEAACKMEKITWAYDTLRDPKQMQEWQRYGKAKGPDNDSSASKFHDSMNSSKGGGWFPFRTGRGKGDDEDDDASLIGEDDATDSKSNMRSSSSAVSKRKKSASRRPNASSPDRKDKKKISLLATLGFPGQHKDGSPKQDGKEKKISRFSKFRFTGRKEDESVSENAENEAPEDIPSIDPMEEETSVKKKKKKKKKKKKVSTGDDENAGDADDEQSRKTKTKKKKKKKKPKSPKPVDYTWKREESKLVMEHSNRTDNETFESSGSSIEEEHPIMLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLB4</accession>
    <name>A0AAD2JLB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Subtilisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1961017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042072319" description="Subtilisin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="32844" checksum="DA401399B600D6A4" modified="2024-05-29" version="1">MKLSTLFTIILVNAKTAPLQGACDYCTAGFDNPTVAISLSDVLPFSFLDDAEANVTSCQDIQNEAANANGTTEECEAIAQLEPLCCPSTTEQYVCDFCPDGVEVEDNFVCGIFSLAALGANETGCASTKLYEPICCPSTSEYKLPTVTEGETCYICGSADVAMTTPDAIPLFIQGSDDPAAQLTCAQQQDAINEERKTSGASCADAISGLYLFASPSICGCSGYSPPKSCNICEGGTVKRDVIPLADEGNLTCGQGYDTFQHFTPGFCTTLTANGELDLAVLDEACCTYTSSGHVNGLHFAGWLIASLVAIAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLH6</accession>
    <name>A0AAD2JLH6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS19283</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <text evidence="10">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="97"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="353"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1961611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1002" mass="112157" checksum="4AB1FA5D353FE6BD" modified="2024-05-29" version="1">MTPQELEQYVQLAADASNSQNQQQAMSLLFQWVSSSTDTAIADILLGVLKATQKEVVLFYCLTTYHRLSQTTVEQRAAFRQELLSQVMGNGSCWNPVYIRTKVGVLLTSFIQVDFPHAWPNAFNELQDPSLLQAAPDIFLRTLVTLTEEFGKDETEVNTKIKDLLRGFTVNEHQQNQQQQQQPSQPSVSPVQSMSGQLMGTVLPMLGQSLRAATNTSLNTQEALSIALLCLSVIKGMMPWVDLSLCLDETTLSLLFSSLSQSATPDSIVADAGVTAMECLQELISRGMDDDKKIALLVRTGVLEQINATVNLTVVDESPIDVVMEVAKFINLTGLAVVPMFSQQQKQENHPIYVQILELFFRCFAYDDIDVSGAVIPFAGLLVTSHEKEPLQEQVFGQLLNVTYRQMRYPADFQYDHEDDDEAEEEMYRVELRKLNQKFVRAAPEACLQFLCQILSQLPMPLSTAQTPDVEAALRLVYHYCEGVRPPPGLKVVMKNETFRNLLVRLHTSDITFHSHQEVLIMYYDTSVRYYPLLKDQPELLQLLLDALTGNRGLQHPSSRVRSRCCYMLLRLIRSIGKGKAANSSVLLPYVDNAIAGILQLLDTSSGQLRIDDILNLFESIGLLLGKTGLDPAKQQTLLTQVMTPHVRSIERVLEQGQSIAQNPDAHGEMLAGSIAAIAYLSKGFKYPSEGIQMVLVEALRINIAVLEALPFNDDVRNKMYIFVQRMILCLEDKIMPSMPRILSLVIAHCTSEDILDVAQLFNQLCIKYKSNAVPVLDANLLPFLQKCQTLSTMSTAAPTPENGVAPHLRTEQLSIHKLTYASMQHVAAYRAEAIFFSPTNSSNFENILNSMLDGAIHAEDPLMKKTCIMFFKDLLDNWTGGGNQNNDASNHAPVVVTPPPQGFVEGYVRFVVNSLVSGVVASFLEENFNCEDANQWRSVSEFAAILEVLRERLLDLYLQEVLMGKFTNTFRFSQAVVENFRLVSNRKQMETALKNMIKTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMN6</accession>
    <name>A0AAD2JMN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46713">
        <property type="entry name" value="F13M7.16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46713:SF1">
        <property type="entry name" value="F13M7.16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="2">
        <location>
            <begin position="268"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="368" mass="42839" checksum="8AFDB3DFBE20573E" modified="2024-05-29" version="1">MELRKCEELVNELSGLYESLRKASKIKEELLPKLKGVNGEALEGAETDADDSTDAAKTNPPHSLANAVELIHHVQKILQELEPKMDKFQKRLDEKDPISGNPRYGEKTQQRVTYILHIYNSVKQYVPDDRISAAEGTVTNSTDVLLDNPLRLLEKQYLKEQEEHKMQIELEEKQAIEEQTKIAEDERRRQFEAEQKQKQQKEEEERVLREERERLHQQAEQVRQERAVQHRQEQEWFESIQKGPEGVKHYLEKLKQSTSDQPALVHTKAVESLYRIFQQINAHPEETKFRRIRRDHEQFVEDVGRHGGGIEVLIAAGFVLGAIDDVPCYLSIEPNIEKDMDGWSKWFDVNKATFEVLEEAVQNLKSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMW0</accession>
    <name>A0AAD2JMW0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMW0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02019">
        <property type="entry name" value="NK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="117"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1104" mass="123442" checksum="12C0FCEB6C19FE28" modified="2024-05-29" version="1">MDQHVGNGRTSASLKHGDEFTASTSGGATKNSVKGELSGEFEPSKPIGPAGRKESYHLQELTINKLKFDSLGLIGRKRERDCLKRCYRRMMGHEEGSSSKSSDENDSKVQGNNDKTKGRRELIFIQGPSGVGKTTIANTLKRDIAKEESGLFVNGKFDLSHSEEPYSGIAQALGQICVAIKKQEVMRKRKNPLGEDEPSTGAITEKADFATELISALGSEVHLLVKLVPQLEMIVPDLSEESPEPFFDADAGRNRWAFAFRVLMRAMTSCFAPIVILLDDLQWADASSLELIESLISDEENSNALMIVGCFRPEEVGEDNYLAETERRLEKKVAAVQYSFTVTSLELDNLNVDETHEMIMELLNDDDEDHSRGLAVICHERTMGNPYFLIALLGMLEEEGLLEFQFALLQWIWNEDDISYKTMSTTSIVDLLQRQMKKLPQNVQLMLQYAACLGSSIRVSTLEVLWDTHAVAVLGERSEDLSRLFGELEDAAHFIEYFGVKSFRFVHDEVREAALSLAAEDTVSFQFAVGSSLFHDFGVDGLDELLFEVANLMNKGSLETSVELANLNLKAAEQANKMAAFSSALMYVSKGIDLLPVDRWTNNYDMTLRLCTLGAELAFALRQKTTVEKFCKEVLSQAFCTEMEKFPINLTKCLTLYTMDENTNESIDLCLDVLAELGSPRWNMAVISMGSSVPLLKAIETAKTLEKEEYQALPKMEDPQLLSIVHLLVRLTYIARVSEKPVIVDLCTTQIVRMTLKYGVSAESGVGFANLGLLAASVFGDYEVACFFAEVSGLLQSIVPSKYSESDVLATSCQLALPHTKSFSDCLSPALRGYQLGMQAGNLNGAMWCLMTHSLMYPYQMGKPLLGILENCSKTLHQIQDLRQKDQHLITRMFWQMVLNLTGKSKGKTNLRGAAFNEEKKQTVTALERAYLDAFRLQLMIFFGEYKEAGTLVIDTGGFSTIAPKYFFGMVDTFFRGFAMYLLAHRTRKRKHLQLANEIQTTIEKWAQNGNPNVQHYHLFLCAEQAAYDKKSTEAASLFRKAIVLATRTGHLHHAALFNERCAAYLEAEILESCQSLEDIDFRKSETVRLYTAWGAMQKVKLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN43</accession>
    <name>A0AAD2JN43_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN43"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="985" mass="103090" checksum="C470F23AF6BCB1C1" modified="2024-05-29" version="1">MSSPLKDSKASKPDNMTIIENADDAAPTNGGEKTRIRDRSSRKRRSDSKGRRSRSASKGSKSSHKMSSGSGHRRRTKKAGMKSSSHSKESNSGPSELLYGDKNTKAKANASRGTTRSLKPGAELVSSSGKRRDTLSIAESTEILYGDEDAKSKAKASRSSKGSLRPGAELVCSSGHSKSTSDTAHTIAVLYGDADAKSKAKASSNSKKSHKPGVERFSLSGHSKSTGDTDHITAVLYGDEDTKAKAKALRNFKRSVNPGVELVGASGHSRSTSSSNQSTQILYGMGTEDAKAKSKVMLGSSSHQSSKSIGTKSTVEILYGDDDDDDAKNKLKKGSGSSRSNKNPGVERMGRSSRSMTPPVDGHVVPWMMIEDDSNSSQAKDSIVGDGQTVASKKDRKSGKKEKVSNKLWIFLTVAILVIGCGLTAVAVLRKGDDDQGEQVQEHDSYDPTTESPELVSEAPAGSPNGTPTAVPSKKQVLDPPSPEDCAAIRNNQTIPGDKTLSESNWNANIQINVKGETGMTDEMVQQLLDSIQELLLPAMAGCTNGNHRKLIELEKTVIPGASKEMEEILDESRYAILFASVNGELLKDAVCVDATTPELCYVVLVEFSLLLDADITSAGVEAIISEKWANGKNMVSKLELDDLFLSVNARNIIDVTPSEAPSAPPTDVSSRLPSNSPTKSPTAQPATEGPDSIPTLVPVPQSTRVPGTPTSIPVEAPTLAPIRSPSAMPTGAPSTTSPSAMSLMTPPSASTSMPVVGPSPPPTVSPTTLVSSPPSTKPSIATDALSTPSPMIEQTLSPTGLTSSPVSTKPSMTPFSSPTYMPVVGPTPPPTVSSTALASISPSITPTPDPTMKPIVATPNPIAIPSRAPTAKPTPGPTPAPTSAPTPIPTPNPTPEPTPNPTTTAPISRAPTSLFCCSKNLKDCNIPDPSCNSSLLSCSNCNGYFIVQGSCTGIAKFEDCTNNLLGCCATLSCVAQDLFSSRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPD4</accession>
    <name>A0AAD2JPD4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPD4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="116" mass="12780" checksum="0B39E2BB0FFE8F0F" modified="2024-05-29" version="1">MLNVLGRFSPKTGKHASKSVSVKETDFTMPHWEGHEIGVLSTLAGCAGILHGSMPKGWVRSFIHRQPVPAMSVFMFSVGVLLPVTVVPLRRAIGLPTNQYDAEHPKVKYPKFEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPF6</accession>
    <name>A0AAD2JPF6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPF6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="393"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="490" mass="57064" checksum="34A7B79FE2DD8B0F" modified="2024-05-29" version="1">MPRKNSDHTSKLEMKQTEDLLASEMNRLSMQERANAFADVHCVGEDIQETPEMVQRSLEEFENTVQKERNPVYEMAVNQNRAYVEDPKFRLKFLRAKLYDARKSVRQMMSFLEQKAKYFGNDKVAREIDLSDLSKEDMELMLSGLYHIQEGRDRMGRVIVHFFGKNLSTCKADDLIRALYYIWWAIIIPLPEVQRKGVAAIYNDTARENHGMPDFNFFKETLLFFTSLPVRFSVTHYCRHAELGRTLTLNDPLLSFVLDRLPTYFRTRTRIHHRSSMELQYQLQSHGIPTDTLPLDVDGNIREDILNLWFDKHVKESNQNNLFHQAKVVQTAPEAMEADNSLLNHAPVDANEDEARNALMKLRKAPGDQIRGSDGNSESDDLATAVIKPTDNDLLFGKGYRLQMHPGNIRVREQVLRTRDEYENTPRMKRREISMRLAQMFRSNGVRFLKKAESGEWIESSIVEADKKIGQIFREFRKKEQRGRPNASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPW5</accession>
    <name>A0AAD2JPW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="443"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="530" mass="57445" checksum="F3C8E51B90081595" modified="2024-05-29" version="1">MDFESSVKRLAKDQSRMRGKLRSGAGGKGVVVSEKAKRQAEYQRKQAEKKRQERERQKKLEEYQKRYMRQCERALKTRHLSSSAAGPGTASLVLSPTSIYGDGDKIALPPSVLETLAQSAMSSSLDQSSVGSPWTFRIGILNPDYQFPSSILIKTLKPPNEDFMADSDSDDDNENDEDEVGEMQAFQDELSHKYLAYTHCTVVEFTQDEGHVGIPPMVAKALLGRNNANTEVGNNTTAHIPVKRTVDPAAAGADPDETMAPGAASSEDQTPGHLAWGAFDIPDLSLEITLLQLPKGKGCTLVPTKEAIQNNFYGLKDVKLVLEQSLIRTRATLSKGDVVCTWHRGVQFDLKVTKVIPSTYDAVTCINTDIEVEIGEAETPPVTKDNAAKASAAPKPVGGFTTGGQVLGGPSTTTPTPIETTASAAASPAPMEADLLPEPPVDVKQGVCTVHIQHSQGTGKRRFFVAEATMKDIFAFGDYLLASAGAQGRPYRLATRFPRKVWSLDNDNRDKSLTDAGIAAGQERFMVEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVA0</accession>
    <name>A0AAD2PVA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="348" mass="38956" checksum="15E01DA17F1FD14E" modified="2024-05-29" version="1">MINDFYFDRMNKVNASDFYAEYHGHKVQHLKVVYSCLRKETEQGLIWTAGDSSLDNKYWFRDSRPAVGAYRDALEPAISNADVTYWLNYHGINERRNQKYAAINTAIEATTLNSRAFRLKAQDKFLRDNIQQDDVLIVSVGGNDIALAPTPCTIMSLLCLPHMCMPYSKVFGSIPMDDKCCGCGCSLLSCGCAFPPCLGYLVHLFGTRVQKYIERLISKTRPKKILVCMIYYLDENPSPSWAGPALGALGYNSHPERIQLLIRKIFMEATSSIQIPGSEVIPVPLFNALNGKDHSDYIARVEPSSKGGEKMAEYLLDMIDNGPSPSQSVLVSTTQMMPVESSYIADRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVG3</accession>
    <name>A0AAD2PVG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001880">
        <property type="protein sequence ID" value="CAJ1955079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVG3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="271"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="846" mass="96575" checksum="C9AB02C0B1A09D1A" modified="2024-05-29" version="1">MDTNADTCCLGKNFIIMSYTPRSADVYAYDPALPPTNVPIVSGATAYDCPQSGNTFILIFNEALYYGDRLDHSLINPNQVRKFGIPLWDNPFDETRNIGIETKPTFVALKAKGTKLLFGSRAPTDQELANCLHIDMTSKMPWNPGTVQLGKISTVQEDPIDDPRSNEAELRQLDPIMQGMNEWRTVQQTIVDGERFFQQVGRTDDDARFVDVPVRPSFVSTERHTKATAENLSERLGIGLHRARATLRSTLQRGTRSAILPLARRYRADRMFLRPRLKGKFSTDTAYFNHKSIRGNIASQIYFHKSGFYSCHHLSKVDDKQVGPTLKKFIADYGIPEHLTMDGAAVQVGRNTSFMETINRAAINYHISRPYRPEENPAEGGIRELKRRFYRLIVKHAIPERLWDFVLDYVVDTMNITANYSRYSDGRVPLEVITGITPDITEYMDFTIYGWVYYRTDGALGTNEIGRWLGVSHRTGPMMTYWILPKSGRPISTDTVQNITEAEKQTDVVKEQMAQWTTDVSKILDARTGDISWGKDEIPPQLMFDLESEDEEFKCTFNKLIKAEDVDNGTLQGTTETDDIDAQNYVNMEIGLRRGQEGELQHAVVHRRLVDAEGNPMGVANNNQLLDTRQYEVEYEDGSTEVLAANLLAENLLAQVDKHGHRHLLMEEITEHCSDEEAVKMKDAFYPLASGAQQRRHMTAGWDFYVTWKDGSSNWIPLKDMKESFPIEVADCAISKGIQDEPAFAWWIPHVVRKRKRFLGKVKSKYWERTHKYGIRIPKSIKEAIEIDKANGDTLWQDSIQMEMKNNRVAFEEFDGDTEKLMGYKKITGHLVFDVKLRLVQVTNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVM2</accession>
    <name>A0AAD2PVM2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVM2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042076932" evidence="1">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="163" mass="16863" checksum="598C3B849CA4D589" modified="2024-05-29" version="1">MKLSLSSLLLLLLNLALCVSSGQALSLETSHAGRRSLLGSALIAACGVAALPSFADAVGLGKVGGDPSVFCGTYSDPINHPGGKRTITLLEGKTGDYQLAQVQGGGGIGEPDNYILPAVILGDRSIIIDFSAKGGPRDFVGVLDGKTKDIKFLRDGNRWPRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVY3</accession>
    <name>A0AAD2PVY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001966">
        <property type="protein sequence ID" value="CAJ1958081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVY3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="249" mass="28410" checksum="1E7E2A4F602586B6" modified="2024-05-29" version="1">MGKISEHKRKQMRTDPPLTFMTVGSLATMEQARKLDFSVNEVLAVMHFPIGLNLRDTANLKGIYDTGGCCNIGEKAYHLTIAKQYPQLVKQVYDFPKIHYAPIKIGGMKDSVNIEAIIEYYIPFTNEDGENHTLMIGLTEQLPINTLFGLPFMLKAKMAPDFHRKTVTSSLFNQQFELTMERPTMLPVEHIRRDQAASPKVLFNNNKRKRQDREPSSSENTNTARPTPPPTLHQRKHNADQSRDEPTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVZ2</accession>
    <name>A0AAD2PVZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Casein kinase II subunit beta</fullName>
            <shortName evidence="1">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001973">
        <property type="protein sequence ID" value="CAJ1958356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042070413" description="Casein kinase II subunit beta" evidence="3">
        <location>
            <begin position="26"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1958356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="475" mass="52424" checksum="0AF498301FD167AC" modified="2024-05-29" version="1">MAVKFQRSLLFLALFNASWSSFAKGFRRSQRNVFPYHTEESSDTGNVFQSEASEKSSDEEQVLAAIARAEDSGNDISGCYSRTYHQSFDLSDDNAFSSLMDQGVDKPLSIRANKRKRELGITDAVESKSSSLTKAPLSKTSLLLGAQMKQQPIGTNRSSSSGPHSERWQPRTSQSTSIRIGNNVKKQSAIPTQQLKGSISDAAKSQKSSSTTTPWIRRYLISRPRDVLLPVPKDFIADGFNVARLGPIVERIGFQVAGDDAVAIAKELMQVSTRSYPIYRLALQLILNETDDNSVVQHSIVPPQVLHVAAEALYLMVHSRFCQSARGLDSLKRIVRVAMFGRCPRASCDGAPLLPYGASNDFQKNHLDQHCPVQTHHSIRRQSHIQTSGVLRNSFCQRFCPKCGEVWIWWDSKTDGCAFGPSLCHLFLLTHGADIYPVGKLSSKDAADSSRAPFCVMGFRIHPATTWGGGNLKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWJ6</accession>
    <name>A0AAD2PWJ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002086">
        <property type="protein sequence ID" value="CAJ1961167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWJ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="195" mass="20761" checksum="1E24E869790C8126" modified="2024-05-29" version="1">MHEGEQQLEDAFVEIEARDNALAAKDQALAQQKAATAALQTQLDALQRQTAHHLAIDSQPPAQNNEVSPDRCDFTTPPKRRKSKDTSTTKRRVDRSKTGLKPPTKSTRTSTSGHFQQPKQRSWNTSQVQVDTTQMEGDTTTAVSQDESLSSLTAASPGGVHPFFLPSPSGKSGTSGSAKLPSSAGRGAPRSAAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWM5</accession>
    <name>A0AAD2PWM5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042001856" evidence="1">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="255" mass="28828" checksum="179A95A0D2E6DB25" modified="2024-05-29" version="1">MKNILTPTLIFTFLCLGILEVVFSAEEDRGKVAPFDTDIRKDCQQMASHCQSPFFGHIFLQCPKTCAAMLEVPGMVGKSPKGDDELWWESTETVRTIQGKRVATDRWDGCVTVVATVPMLPGMAPYYYEMMETLHKQYKPHVEFILIPIDLGETIHIKLRKKPGVVVLEEESPMAVLTNPFVQYLTSIKPDAGAVVTNHLDELEQLDLHTDRASFFVISSDGYFIESLISPPMKKLQRRINLFLKTVDYAGVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXL4</accession>
    <name>A0AAD2PXL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="51435" checksum="EC743B6B9E2CA09C" modified="2024-05-29" version="1">MNGAAVRTTIQRGIGATARRQIFRQKRIPLTPQAPYQCRSLSSTPPSSSSSSSSVPAKTPEEEENLPAIPIDFQVAANIEGEESQIATITLRPGETLRAEAGAMLYMTQGIEMSTELHGASQAFSRMMTGQNVFLTEFRYHGQDSGTVGLGTDFPSKIVRLSLQDYPDSTIICQRGAYLASNPSIDIEMAYTKRLTTGFFGGQGFILQKLFGEGDVLVKAGGTLVTKDLEEGETLRATCGSIVGFTSTIDYDIEMMKGVKNVMFGGEGLFVATLKGPGRVWLQGMPPDRMIGEIARRVPAGGVGPFIPIPGMGGGGGGEAAGDADAGTAGDVAAGAAAGEALGDATPEEMVASTDAAIDADRQATVASSGVDSESPSALFGDAAGDDASNSTLGSTNTTEPASSSTFGDDSFASETSFADSGSNETTFGDEPMFTDDDATNFSASDDFGQSGEDFFGGDSSQTTTDVFDSVSESVDQDTGSGIISTLWDMFMGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXW5</accession>
    <name>A0AAD2PXW5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002390">
        <property type="protein sequence ID" value="CAJ1968513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="643" mass="73247" checksum="50FEDCCBA3B48650" modified="2024-05-29" version="1">MVYQCQHCEENVSGNDGRLLNMLPPHVSATYPVLPKYACGGFHLHKDASRFLESMMKTYGNGDMVSNLLQQSVGIHYTQKAVSYLSKHPSRPFMKLEEFTNGNWPPSGATLRRLFESAEYSPLNIYGYSNFERYTRECQSVTVVETESIATDHTFQVTNAYGNKEGMKAMFTCIKAPSKEMVAIVGVPSTKLQDAAHCLKQSCIKRGMKPSIISTDMMPHGEEFWKELYGEDIHCQLGLFHLLTRIYSTLDRRSNLFGECLLALKECIYRFDPADLKNVREALKAGTLSNNGKQYTDAEIDEMQRTKVFSRRYSKYLKKEFHSAVQIQSNLAAWIENWDHEEDDFQRPVFTYKTADTTTNQYGKISYVLDCMTAETYSAIPAPPGSKHGLPTFKSNRPESMLEKFHELLAHYCNIGCGNEFANGIIMKGWTEYNVTARHRYYCMRKRSANQLEQLQALDITPTFLDHSLLHCINEQSRDLGHGDLFSNYEKPPSKNNGEVFLKNYFNQQVEQNRNQLFDKDSKQCTCNECKIPAGSPPAVPAAGVEDNNSRLLTCQLTCQMDLMALDGTSTATNAVTEMPPMRVDPPRRQQTFGYCFPFHPYRCDDLQNYVKRRQAGEVVRGRPPHSFNCPTKSMLKGWAPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CA35</accession>
    <name>A0AAD2CA35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS141</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1894169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CA35"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000039">
        <property type="entry name" value="Glucosidase, alpha neutral C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042073173" description="Glucosidase II subunit alpha" evidence="12">
        <location>
            <begin position="17"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="14">
        <location>
            <begin position="321"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="13">
        <location>
            <begin position="482"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="15">
        <location>
            <begin position="819"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1894169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1053" mass="119457" checksum="ADCEC8F7576C00E9" modified="2024-05-29" version="1">MRGLLQLLVLLGITSAFAVDQSKFRTCDQTSFCRRHRGEHSAALYKYRLDKDSIHFHLPSEVEKNEKEKAAAAAMDEAKRQAKGGLWQSLKKGILGGSEDGDGKKDPYYRGTTPTLTGHLINTAPKTSTGHKERLELSLHAMSQGLLRLRITEIYQEHSGPHEKARVTYDELVLETDTMESAEHARWIQPGDSYLTKIVPSAEAENYMGLQYGDEEGKSGMFLLMRMDSFAAYLYREDNLEAGPITTFGEKQMTHFEIRRSKTHEDISASAEDEKSEDEKDDEDGKPEKEIVGYWEDGLAIYADGTREERKVEEEEEDHRKLTELDLDREGLWEENFESHKDSKPHGPMSVGADITFPGSSFVYGLPEHASATPLKTTIGEGAGYEHPYRLYNLDVFEYDLDVPMALYGAVPLVVSQSPKTGTNGVFWHNPTETFVDIFESEDGSKSTHWMSESGIIDLFFVPGPDPKTFYHQYSLLTGVVPQPPMFSLGYHQCRWNYKDEQDVYQVHGKFEELDYPYDVLWLDIEHTDGKRYFTWDHHLFPHPEKMQEKLWSQGRRMVTIVDPHVKRDDHYYIHSEATAKGLYIKDKDGKKDFDGWCWPGSSSYLDFTNAKARDWWAEQFGYDNYKGSTPSLFTWNDMNEPSVFNGPEVSMQKDLKNLDGDEHREWHNLYGMLFQRSTAEGLTKRNPDHNIRPFVLSRAFFAGSQKYGAIWTGDNAAQWSHLEIATPMLLSLNVGALSFVGADVGGFFGNTDAELMTRWMQAGAYTPFFRGHAHHDAKRREPWMFGEETMVRLRKAAMARYALLPYWYTVFREAGLTGMPVMRTMWMQYPSTESLYGVDDQYLVGSDLLVKPVTAPDVVQTTVKFPTDDIWYDAESLTEVSKQGSTGGVMEITVPSDIDTIPVFQRGGSIIPRKLRLRRSSHMMSNDPYTLFVALDGSQVAVGDLYMDDEVSFNHEKKEEYVMATLSAAISDNAGVIKNSVEVGKGWVGSETESSSSRLIERIVMMGVKAAPSSISVGKEALGFTYDMSSNVLVIRKPDVPTTSEWEISIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAH5</accession>
    <name>A0AAD2CAH5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-coenzyme A dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.8.7</ecNumber>
            <ecNumber evidence="5">1.3.8.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS396</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:17721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83721"/>
            <dbReference type="ChEBI" id="CHEBI:83727"/>
            <dbReference type="EC" id="1.3.8.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:14477"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83723"/>
            <dbReference type="ChEBI" id="CHEBI:83726"/>
            <dbReference type="EC" id="1.3.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="4"/>
    <dbReference type="EC" id="1.3.8.8" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1904150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004466">
        <property type="term" value="F:long-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015396">
        <property type="entry name" value="FadE_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007000">
        <property type="entry name" value="PRK09463.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009586">
        <property type="entry name" value="PRK13026.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09317">
        <property type="entry name" value="ACDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="13">
        <location>
            <begin position="118"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="12">
        <location>
            <begin position="331"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase C-terminal bacterial-type" evidence="14">
        <location>
            <begin position="485"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1904150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="796" mass="86647" checksum="89AA97CABAE45842" modified="2024-05-29" version="1">MLTARRTSVVKSTSTMAARVLGSTGSSQHTEQRRTLLGISKSLDQRLYRMAKGVMPPISKTEEIALGCGTIGFDRDIFSGNPSLKHLQDTYDPKLTAEEQSYLDNEVNTLCSLLNDHDIAMNKDFTKEAWDYMRDHGFFALKIPKEWGGKGFSTHAVSQVLVKLGTHSMDANATVAVPNSLGPGELLVRYGTDDQKEYFLPRLSDGTLIPCFGLTGPHSGSDATSLIQSDCVVEERNGELGVVASFKKRYITLAPVAGVVGLGLNLADPKGLLKGQGEGGFTVALLERDHPGLRMGPRHMPLNSAFMNGTVEGEDVWIPMDSILGGQERCGKGWQMFVECLAEGRGVSLPAGSAGAGRVIVGAVGAYSRVRKQFRVPIAEFGGIQEALSTAGSDALITIAGTDLMNAIVDNHEAPMVISSIMKQNCTERGRRMVEHGMDIAAGSAICRGDNNYLGNTYMGLPIAITVEGANIMTRSFQIIGQGLTRCHPHMLELIQSLQMPKEEEDKAISIFTKQFYKVVHHGLTNFGSSITRGIGATFSTKTRSKTAYTDGKKMVDYHEKQLLRLSANFALTADLCFTLGGRLKFEELLMGRLADAMGAIFLGYATLHHYSRQKGVEGLEAITEHAMLRLEKEAQDALKEASDNFPGPLGPVASTVMKMGCFPLGSLTRPYSSPSDQLTKEVSRMITTPSALRDMFNENVYMAPEGETHQVSDLIRALPICVEADKIASTLRREKREPTAEEVDKIAKAEAIRDVLVQVDVFPHITDAEGQEGYVRPALVGTDERLSSLDRKKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAK4</accession>
    <name>A0AAD2CAK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1906341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046527">
        <property type="term" value="F:glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="188"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1906341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="452" mass="51437" checksum="DD6A2D2507DB366C" modified="2024-05-29" version="1">MVRIPSTKIPWSHIFSLGALLVILLVSYRASSLLINLAGITGKKKAPTNSTQIISTVTSSSTQHQRCQRLDIAQIKHIYDDHVVDSLSYSSDISEKDADRIKGGDFPTTRFTPHIESILNDIDLEGVEDGCKWKFYFTVDRPLSKPSKIFCMGMKRSRQVPWACKIFNNLFDESSGNHPFPSILPSNLTIAISTDDFSDVEKEGFKCFASSSAGGRFTITNFLELQRMADNTAHPIISFDERCTTPIWRGSAWREPGPINAQDDSTILEQVAQKSTRIRTVLYSKKHPGLLDARISDSKNGLMMEKGLWINNATNGLNKVLPIQSIPPSEYYTQFQTALVLCGRGAAFRTPIHLSTKTAVVLQTCPYQEWYQEYMIPWEHYIPLDQDLRNLSETMEWVRDHPAELESIAKNGRQLYVEYLSFQRNYDHFFELFYRLAILSAERNIAFDPPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCF0</accession>
    <name>A0AAD2CCF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1910295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCF0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000004">
        <property type="entry name" value="40S ribosomal proteins S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006345">
        <property type="entry name" value="PRK08572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1910295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="165" mass="18933" checksum="5F9E5E73A87C00BD" modified="2024-05-29" version="1">MARVPKEYVECDQHEKAYQKQDAIFVARKRAVSASRAKPMRFVKNVGLGIKTPDAAIEGNFVDKKCPFTGNVSIRGRILKGQVMSTKMKRTIIVRRDYLHYIRKYRRYEKRHKNIAAHCSPAFPVKDGDLVTIGQCRPLSKTVRFNVVAHEPQRAIAGKKSFRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE88</accession>
    <name>A0AAD2CE88_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000036">
        <property type="protein sequence ID" value="CAJ1928221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="490" mass="54315" checksum="EA6B4B6F67118A18" modified="2024-05-29" version="1">MAPYFPLVQSSGTGKTKLMHEYKKMMDKTDGIHVGLILCHDGSAVEMMAEGGSSMFSRTLDISKISVDGPGRDELHLTKRDDGWHFRCIRWWLRLSNRPSDSSVVGVFAGTTTRLANYYSEPKPSTTSRSANAKYVGGTKLYPPCYQITTTGLVSRTDGTKFGNAGELRDNGNEIITEFDVATQYGRALFGRMHLRRELKDALGNILLRMRGEDKKLSLQKYYSLLATRLQRGQVSSDFASELVASGYAHLTYFSPEQAAVAEIAFLPDPGDVGEVAAAFYMLACVDELRYEQSPGLTQLSVPLEKWIGRLQQSQGADCETAFNSGEEKASVNFIQVCRHHLLHSLKEIQDSGLLRHWYLGGRASYAQASCQAYDMVVPLQYTLDGTLHYCPMLVSVKNRLTYRPKQRESAIEAMEKIFEAAGIETGVCMLLLVGLDQPSAESSSALRFSHNTASTVVGLADLETARFSKAIVDKVSRESQEGYQTIILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEM8</accession>
    <name>A0AAD2CEM8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000180">
        <property type="protein sequence ID" value="CAJ1931826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEM8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37874" checksum="EEEA3C2B6B5A47D7" modified="2024-05-29" version="1">MSNAAKGGGDPWAWLGLLKWSLSYSDGTRSNGDIAPMSKEDREFLEKVMAEGIIDENERMKFILQESTKAMEHYRLKAMGTHPDSDPPISDDDLEDLLQELRDIVEQIDYARAFCSLKGLPFLIGCMEAKNIPENIRNQCGGILSTLAQNNPHVQKQLLEVGAIKSLSDLFFLDDTTMKMKAKIIQAINAIVRNHELGEQVFCKLDQAQPLFTEGLKKSSSQQLQSRTLFFLRALLTSDAGDTKRSQLFEPAILFVAENYLGESTPSDLRESAVELLEQLWEQNRVPTTLLERKQALVAFGVQRISSLRLLEGDHKEYALAELEHWESFLVVLARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFE9</accession>
    <name>A0AAD2CFE9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="361" mass="40088" checksum="04B1F94DFF5849DC" modified="2024-05-29" version="1">MANASISLHTNKVDSVAVFAILIKQHLHQLPSAXXXXKPKVNPRARATAEIDVIPPEVFAVRGGFLRPKAKNENLLHRRNVIETKKDERPIVPRRIDSVLSRKALSSHVNKRRGTVNDGVADTEDMNEEHKTSAKFESDHQNDSILPLKKVEVPSLRARMTRDMSEITLNASQHPEQTEDIVLSPLHKNKAKKSVISPQRKLIPSVLCQMYPDFEPSESGVGGRPYVSFQASGDESVLSSLDYDGFEEDSYGDHADVNVSMRSQLSHLSARTPTLSPLAEEEDSEQESGGAFSKNKRPSVAFFPWPKRQISSTPAVAEKTMDGASKKPRGTTFRMPTFKKISIRGRFSTMKLRDGTVVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH81</accession>
    <name>A0AAD2CH81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS2945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="73"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1932655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="495" mass="56068" checksum="FB65169B5C388AA2" modified="2024-05-29" version="1">MLSSRHDALSVSGIGNRARGEPKNSASGNNAEWSSGDQAYNITQFLLEVMKKDSHLFQNSPSLTLPKFKSNEVSLEKNLGQGEFGVVFSIDAIHTKVDEEEEEETPKHDRRSVSPENETSATDDETETADDSLRIDDNPHQNDEPLAVEIFMDCKGIGLKGALPPGLEQRDLELLLEPNVSKGYMRKHIMRGGMSRYAIKRLKKDLRGPTLTQATADLASEANFLMTLRHPNICRMRGTIGEPGKRGFSIVMDRLTLTLREKMVEWKKKDDSGSLFSKLKKILGNQSKSKLEEKLMFQREIYGEKLLAAYDVARALRYLADHSIVFRDLKPENLAFDLRGDLRLFDMKSPGMYKMTGQTGSRRYMAPEVMVYKDYGLAVDVYSFAIMFWEMMSNRDAYFYMGPEKHFETVVTRRKRPNLKKMISKKVAPQGSIMCGLIEKSWSHDPSKRPGIQKICEELFSEIISVSNEEGKAVDRSSHLAAGSLKSRIDEPLWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHX6</accession>
    <name>A0AAD2CHX6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="124" mass="14843" checksum="26601E52BC4246B7" modified="2024-05-29" version="1">MYYIVYVFTFKRLFDAYSDPVSYKQKFLDQNAFLVYYTKGFDGPGRPNIEEDDSNEKQTLQFGIRNEAWINWENFLVELKFVGEEKDTEATKYLDETLRYVDYYLKLAPPQDVREAKKAVDLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIB0</accession>
    <name>A0AAD2CIB0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000313">
        <property type="protein sequence ID" value="CAJ1933920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIB0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF18">
        <property type="entry name" value="DUF1279 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="98"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1933920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="223" mass="24833" checksum="372737E2556DFA91" modified="2024-05-29" version="1">MMMRTTTRAATRRAGYTQFRVPLSPSWLQNGLIHLPSRNEEYTKHQAIEIPRIALPARYFSSTTNNSSADRGEKKMTMKERGKNARNAGKKGAKAVGEMFRRYGPIFVGTYLTVYGATLGSIFLAIESGLVDPAYVLMKVSSTSAEAKSTGDVIIELLDHYSWTRPAVPILEKHPEFANLGVAWVATKFTEPLRLAITFPVVPRVSRAVGWTKPEEEEEDPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIJ5</accession>
    <name>A0AAD2CIJ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS3629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIJ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="6">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="784"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1095"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="195"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="665"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="793"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1934184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1116" mass="128566" checksum="15B52EE527EBF472" modified="2024-05-29" version="1">MVDETIDHLQVVGDFKHGSIKRIKLVNFLTYAYVEFNAGPRLNMVCGPNGTGKSSILCAICLGLGGEPRLLGRASEIETFVMNGEDEGQIEIELVDTRGRDNPIINRTIRREKGANKHPFTWGGKQVSAKHVREQCLKEYDITVDNLCTFLPQDRVGSFSGFDSKQLLVETEKSLSSSQHLYHVHQELIKDQEKLDGGENQVDTLRDRIEQLKNETRRFEREKERMREREEAMKQAELLEKKILWLEFDNCRNEAVELKELKTQKKNAFRELLSQSEPLQDRLKQLSNDLRNQEEMYKALDKEVQNHQKEMQKQAAKYEKHDDSIENLLADLNQLASARKHQQHKVDQLRMKVEEVEQKISECNSMENLEEELRIAQEERKQINPMLQSAKDGERKLSEKAREIAEERKVQENRWKQLQDEKAQRQANVFRQQQPLKKAYDWIQQNRDKFRKEVLGPVCCEITPKSRNCAAYVEQHVSNNTLKAFVVQTRDDYDLLYKNIRQNMKLPLQLVLVEDFDAAPKRKYSAGKMQMLKQDHGVIGYLDESFTAPPVVMAALRSRHAVHDVLVGSDSTQESIDKRHLGQLLSEPEDGSGRLQQYCIFTSQGEKSFQYLASVSKYSKKSNLRIDDVRPAKWLAPGVSDTRKQQVKDLLDKCDKELDSIRPEIEKYRADLQIYQEQAKSSLDQIKSAKENINVLRKFITRKQSHAKKLKEEEAKLSVDNEEEKREKVEKLDARVRGSLEALSSHGQSFKKMMLATSKSSGARLNKEVVAVEERKASAEFDEMNRKVQAAHQESERAKESFNNKRRELQQRKTRAEAEAPLTDSNGEPLPLEQQLKDIVIEDLENANIALEEAQQKIESIVADPNVVRVYETKKAEMEAAEMELENLTSSREKTLIEIRTKYSPWMKALEASVSDIDKRFSSYMRELGCIGEVGLTRGNQGEGSEYGNFKDWGIEIRVSFRENAKPQVLSARVQSGGERSVSTIMYLMALQEMMVSPFRCVDEINQGLDDRNERLVFKRIVENSCKPPGPEGLTDHCGQYFLITPKLLPNLVDMEVEAITIQCIFNGPFNLKHPSDWNVRSLIALRNNEIENQVTDEEGDYQEQSPSKRRKLDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIL6</accession>
    <name>A0AAD2CIL6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000480">
        <property type="protein sequence ID" value="CAJ1935555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIL6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="54181" checksum="C8730DE851553F23" modified="2024-05-29" version="1" fragment="single">MRQVASKGYYSVAAHNENRARPIASCSQYGGCVATILNSVAHRAKSFGRDPTKLGRWAYVRVQGKKFAMPTPDDQVREASDASRSRFSRDLVVVSAYRPNPPGTGESTVWAQHRSFFRSQGRLREPREAFMVDLLRAITQWRDEGCEVILGVDANEDISSTKSSSFRQRLRDVGMEEAILQRHPGRMVATQHRNKRGTPIDGIFTTSGVAVQAGGYYNFDEFFSCNHRGLWIDIDLEKSLGGYKPQQTPYKPRKLTMLDTTAVRRYLHLVHKGYEEYSIPSRLASLHHQLQLNEGTMTATMGRHYNCLHRQMYVVRRKAKEKCRRVTNGLVPWSPKMQQFWDCQSLWKILLKGGKGCRVSSRKIRRLMKKVGILDAWTKTTTELEAALCQDRKDYLEAKTHYAAKWRKDFLTVQAAKSKKKQWRSRKATDRFLRLRRMKQREEARRRRRAQGKGSTGGLHAIQVEERLPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKV2</accession>
    <name>A0AAD2CKV2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKV2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="459" mass="52377" checksum="C3CCFBC2EE5635DB" modified="2024-05-29" version="1">MIQKIGTGSLLLASGAIIGVLTTLLVQARYELSQKGNSKDDDRRSKGDKGAEGAGDECTNSSVKYEDDGHLRCPQNLRDAKLKRDRLPSLIILVRHGESQGNADHTLYRTKPDNLVELTKKGMKQAHKAGKRVEKIFHKMDLQAHEQKQQSRGEGTCQATHSAAIRRTHLVISPFERTRQTAAAMRPWFAHRVVRTDIEPRIREQEFGNLQCHDFDDFRREQKRVGRFWYRFPTGESGSDVYDRVKSWWTDSVMNVNERYGYEPVDAIVVVTHGLTMRFVLMQLFGWSPQTFHSVWNADNCDAYVLRKDLSKPGPSPYVLDEQAGDMPKSSIDVKVEFDGSNCQVYKLNEYLKIPPPRTQQLDLVKAKLEEQYPEIDKKCISSVMFLPFIQGAVAEQRTKTGRRASISTLPPHQSQNHLPSQIGDELQQLNHQVRRLSELGGFCPNPELYAKPEESWQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKW7</accession>
    <name>A0AAD2CKW7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000473">
        <property type="protein sequence ID" value="CAJ1935451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKW7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="98" mass="10954" checksum="7F39F5F916B5D79F" modified="2024-05-29" version="1" fragment="single">MDWVSTPYTGRAKFNERSPGVTRPHGYARKIHAKRVDGELRSLLNPSTAKPDFPFAAPATFISDWKSAQQGLISVKAYGPVKDATLTLISKLRDYYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKZ8</accession>
    <name>A0AAD2CKZ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000546">
        <property type="protein sequence ID" value="CAJ1936111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKZ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="122" mass="14256" checksum="762B76363F91C6F0" modified="2024-05-29" version="1">MSRRRRIEKSKLTFTGTYSSLNCTGTETSAVHQTEKKVELLRQALPYWAGLYLIASWIYFMIPALKGLPFGDSTHNRSWQSCWTFSKNESLRRLMSLKVEAFALQQEHRYCKAFDDNHAPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLG1</accession>
    <name>A0AAD2CLG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000303">
        <property type="protein sequence ID" value="CAJ1933829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="70573" checksum="D98FB834C45467A7" modified="2024-05-29" version="1">MMNVDDEGNTMYRIREFIDHQRDGRAVRGDDGWYTTSNGLKRPRKTTKGWKLLAEMKGGETEWLDLSVAKEAFPIKVAEYAVANKLVSEPAFAWWVPYTLRKRDQVLKAGKRRAVKRQKPEKFGIKVPCPGPKGVARAYELDAQNGTSHWNDALIKEVKTILPALKILEEDEDVPVGYQLIELMTVFDVKMDLTRKARICARGDQTDPPRSVTYARKEFGEYAGKKAILVKAVYGLKSSGFAWRSLCADVLKEQLEFQPCRGDMDVWRRPCQRKDGLKYYEYILVYTDDVIAISENPKAIMDKLNNFFVLKPDLIKEPTTYLGATISKHKLDGDDYFTWAIGSEAYLQESLRVVKKRIAPMQLTLKKKVYSTLDTSQNLILLLLLMMTLLFSTCNSSVFCAGLWNLVKHPDRVLVMDCGYADHLRPLKKADYSQFYEFTKDELPSDMPTPLGKAVEFTMFVDASHAANVVTRQSRTGVLFFVNKAPIIWYLKKQNSVKTSSFGSEFAALKTGVELLEGLRFKLRMMGIPIQGYCHTCVDNMSVVKNSSVPESQLKKKSNAVAYHYIRSRCAIDILRIEWIISAENLANVLTKIQPGTVCDRLMEHIMWKAKQNGKLALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLI5</accession>
    <name>A0AAD2CLI5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000679">
        <property type="protein sequence ID" value="CAJ1938176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLI5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="271" mass="29521" checksum="DA58B7CBB4BDBF26" modified="2024-05-29" version="1" fragment="single">NARNMMDFVRKKTSLKDIYEKSKEDATDTTTTNDTTTTTTTTETRNTENESNAVAAAAAATSKEKAPNAGATTWYPHRTAMLANGAAMIHCPRTNNYRGTGALATIAATTMANTVLPSPEFLPALNNRNKKRTRMEADAAFKKKQEEEEKAHRNARLPAANSLCHPDTTPLRIPTATAKIAATSMWQELDPKKKLDDDVDDDDDDDSKPPPSDSDKMNTTPAADVMLKPTAPAPTTTTLNSSSSYKAPPSPKKNDEKEATLALLSWRQHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN98</accession>
    <name>A0AAD2CN98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS6065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000702">
        <property type="protein sequence ID" value="CAJ1938294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="15"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="681"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1938294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="932" mass="101493" checksum="222D5D39D993EAED" modified="2024-05-29" version="1">MQNQQQGKLKVVAGYALEKRLGSGSFATVYKGVRVPASAVSAVLAPSSNNEEDCMDSPSHPDVVAIKAISRTSTKLTKKVLQNLEVEISILRTYQHPNIVCMHEAHKTEKHFFLILEYCGGGDVQGLIRTRKSGRLTERLTRRLMRDLASGLRFLWSQELIHRDIKPMNLLLTGALPLDENDDPEKTKESEERRWQINFPSDQFRLKIADFGFARHLQTASLAETLCGSPLYMAPEILQHHRYDAKADLWSVGTVLFEMIAGHPPFNGDNHIDLLRNIQTKPVRLPPNVQISNTCVKLLRLLLNRNPLSRAGFKEFFECCDDFVAIGCGGVEIQSAGTRRVVSKDLGTIQEDDGTANITCSESVMAVATNQEQVMEGIPSQNENTARVVASPALPSQDASPNIVNIVDTTTTNHAPIPNSAKKFSPLTQSPPSPIHINVHSNNNVYVPSVDQPQHPWAQNQQEAEVSEKYDMSRSDDSGFVMVEIGVDSRKDVIEPNGVSMNLIGQRGHVLPTQPSPMYYLNSPTSLGKAVSSRIGMGERKSSKGMLSTSPGTGGFLMGLYGRQRIGYDQTTGDDTNFGDQIATVSKMIAASEDVGRRAVSVAHLGDSRAYLGMRAKSSNEDDDSSLHTTAPMEAEDGTGTISEESTFGEVMTVSRRRSSLSTDKVMAIAEEEEMPFAISPDAPAVSLPSRSNHSTQSKGSSMVSLRKGGGRSESQSVRLRLGEALSCYLKALKMLKSAVGATQRVSKDLETLSSRSGRSPSEYDIPKLRRHCEVTSTWLRGQFCGVLERAESANAEISKMQSNAGDKQPAIATSVEELIYNHALASGRDGAVKQLLGQNEAARTCYRSAGLLVETLLMEAGIGADDRRILEGYVDAFASRINELDKAMLNQTRMLGTSPTNIAQRESGIVGLIGPPTTSVPTGFADAPPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ74</accession>
    <name>A0AAD2CQ74_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-related protein Rab-11A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS7523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001013">
        <property type="protein sequence ID" value="CAJ1941449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ74"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1941449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23864" checksum="275B78A544A9A108" modified="2024-05-29" version="1">MAARVDEEYDYLFKIVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATKSIQAEGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKHGTFENVERWLKELRDHAEANIVVMLVGNKSDLRHLRAVETDEAMAFSEQHNLAFIETSALDASGVDTAFQRILTEIYRLMSRRNVAAEEAANQPSLTAGKTISLSQDSNQKKGCCASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQU6</accession>
    <name>A0AAD2CQU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-6-phosphate 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF39">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042243586" description="Glucose-6-phosphate 1-epimerase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37005" checksum="24F51CED27B53C77" modified="2024-05-29" version="1">MKFSVAAIVASSLLYSTSAFHIQAPSKPSSLVLNASRAAKKKVSRAKWLEKRGFSDAVATTSSESGIIKNDEGLEFVKLVHPESGASAEVYLFGGVVTSYKDGDGTEFIAVRPDAKMDGSKPISGGLSHCWPQFGPGEIQQHGFARNVMWEVTESTDTTVTMQMKPSDYTKEMWDKEFLCNFSVSLEAGELKTVMNVKNEGAEESFDFQAALHSYFTTSSLENLEITGSFEGKEFLNKLVGDEGEMQTEDRSAIKISEEYDRVYKGVNDPVLKDSGTGKALNILNQAGWEDTVLWSPYGNEAMGFDNFVCVESVKFDPVTLDAGKSWEGVLVLKPEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRG3</accession>
    <name>A0AAD2CRG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRG3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053264">
        <property type="entry name" value="Lipoate-ligase_2_inactive"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43506">
        <property type="entry name" value="BIOTIN/LIPOATE A/B PROTEIN LIGASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43506:SF1">
        <property type="entry name" value="BPL_LPL CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="63"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="317" mass="36032" checksum="680C939F7BFF2299" modified="2024-05-29" version="1">MKISKLFWLDLRSSGISALERLSLEEALLRHDHRNWFLVGSHQPLDHKYLTKKDLPSYASPVPNPDCIVVMGVGGKPSELLNIPLVKSKKVLVTKRFSGGGTVVLDSNSIWTTFIGRNEDFLPHGVEPFPRSIMKWTADRLFGPAFNKLNNARLSPILVDENETSPSGFGNLGEKTMQKLDSDVSGPQFRLRENDYVLGDLKMGGNAQSIVKDGWLHHTSFLWDYEDSHMQYLMLPKKRPDYRGERSHRDFLVRLKSIYGDSSDIFVSSLHATCSQTALNVESIPLNRVMEEVVNNKLGGMDTWFEKCRTRILHKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRM6</accession>
    <name>A0AAD2CRM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Procollagen-proline 4-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS3846</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000031">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF235">
        <property type="entry name" value="PROCOLLAGEN-PROLINE 4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042053408" description="Procollagen-proline 4-dioxygenase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="348"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1934506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52026" checksum="5750DCE73C2EB7AC" modified="2024-05-29" version="1">MLRELSYLAFCSIAVVYAADTDQTCAAGDESCASLPECKDEHESCSFWAGAGECDANANYMLEYCKLSCGKCPGVPMVQTAPKPAPKPSSTCFDNNEECEKWADGLECDLNPAYMLQNCRLSCNVCTDPDMVIDLGVPQKEVSDEVPDVTEEQVASHILKSEEYLRTSKMRLSLRRGCKNKHELCTLWALSGRCHTHSEYMSIKCAPACESCEKLTVEGRCPIDPEAPVAWDKGDLNKMFEKLTSEPYLSEYNVEILSSPATNGPWVITMENVVGADEAERLIELGSEEGYDRSTDVGKMNVDGTTEKSVSTGRTSTNAWCQNSCYHDPMAQAVIQRMANITGIVEENAEYLQLLKYLPGQFYESHHDYIPFHIQRQQGVRILTMYLYLNDVESGGGTNFDKLNITVMPKRGRALLWPSVFDEEPNKKDERTSHQALPVGDDAIKYGANAWFHMRDFKTALANRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSP0</accession>
    <name>A0AAD2CSP0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="508" mass="57168" checksum="5D6415C328BC1DA0" modified="2024-05-29" version="1">MQSLTDSPNLSIIGSSTSSSNRISPTNNDSLNQPEGTGIQWNRLLISPQDLGRLDYFSDSWLMNRESFLQINVDTIETVEDACFQVIDDETVSMQHQEDAKDSNGRQQQQQQQHQTTRNKMFVDWTNFSVEHLSKWWKNLQALSHSNPGMADQVVRILKTYLHKVRYNTAKIKPANQQKVAIGMIAFQSYESPPSVGLERGHQLTAHSLAATIGSLLQVGMFGHIVVGGYKHPSDSDRVKEAFTILEGIFLDNDSGGNSHFKNPLSLAIGDTQVAYVQLEESWVQTKRVTANIPRGVLLGMQKALQNEFPPQEQAKWIGSSTARQWQYFYLTEPDSILNTKPKILPLLRSGLDQGWIFFPHRWQPIPHQADLPNHHDSFLSPSRYIPNTVAPFSNVTNIQSPWNDNNNSDHIETSDDVVLHCCDDGMDKPGRTEAFGTKMKPCGKWWWACGFSSLNQPGAALMPNEVLELHKRLIPYPMMRLQGGTSFIVAASEMGRRCLPSKRPCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUU0</accession>
    <name>A0AAD2CUU0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001263">
        <property type="protein sequence ID" value="CAJ1944867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUU0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="278" mass="30780" checksum="5B013B2100F94BF5" modified="2024-05-29" version="1" fragment="single">MRPASHRTAGIKRPMAAAEALLPSVPFWTKPLPDDVCGVTTQPLHGLEEFVISGVGRKHQSPRPVPQPSLFTAWEAASAEVDEYFGWTPEELEIVGDEGRLVEALLSGHLCVISDGSYKRAMGMAAVQLLPRKGEKDRVIVRCQTAGLLQDQSAYRSELIGLLAGIMVVDWLLQSNPRVRIACDGFSALLNTFGDNRVSPHRAQFDLVSSLREALAHSKASWEPSHVYGHLNRATAFSSLSWWSKRNVEVDNWAVAYRHQLEASNQLIAPNARFFTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVY6</accession>
    <name>A0AAD2CVY6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001710">
        <property type="protein sequence ID" value="CAJ1946518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVY6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="243" mass="27913" checksum="998497450AB9BF7D" modified="2024-05-29" version="1">MSGIVSDEIKNNACLLDDLSSDEALILQSKRTQLVVPKGITQCDDSDGKFTWNRVRTVSMDASSVNSNPGHQGSNLPTKKQEKRSSRVLRKAKGRLTDNGERKKKKSVHSNVGRRKSFKKILRKKFSWKNYPELEAFLVANREEYLRHSALNYTIQQKQYNNRLTERMLELAAEHGYIFDDTEFSFVTVRDRIRCYFKSYVQSAKKRGIIIGYAARKAGLLSTEELERSAETKGEIHSPENKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXB7</accession>
    <name>A0AAD2CXB7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042013854" evidence="1">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="128" mass="14158" checksum="6CD4A79901050572" modified="2024-05-29" version="1">MMLSNLLLFVLPTLSLSFMTQSAPRVETALFDGDGTGGWGIGSSRELTPEEFARSDRAYFDGYKMSEQGDFRRQIADDKESLKQQELEELLGVAAIAGIKVKNPSERLNKFEDAGFAADDDEDLDLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYC2</accession>
    <name>A0AAD2CYC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001079">
        <property type="protein sequence ID" value="CAJ1941774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="257"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="322" mass="37017" checksum="092131560A0EEA46" modified="2024-05-29" version="1">MENQMYMKKVNSAIPYMSEILDPLDKAEFKRVFFNVHPKPWKDAFLEINSTIGSHSIASITSYMQRKAGQAHNKELKNRLHQKIESKKKKRTAGVHHRDNSKPFKKSHTDPEEKTKRPRTFVALSHPSATILLADFEEADVYIDNVGIFSNNWNSHLDSLRKILQMLQVNGFTCNLLKCEFCVQETDWLGYWLTPTGIKPWKKKIDAILRLKPSKSVLELRSFIGAVTFYNDMFPKRSHILAPLTARIGHNKKKLDWTPECQKAFDHIKTVLSKDAFLAYPDHNQPFHVYCDASDYQLGVVRWQNSPPGWNGAGSSANSFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBP2</accession>
    <name>A0AAD2FBP2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">15,16-dihydrobiliverdin:ferredoxin oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HY2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1898506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016636">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010024">
        <property type="term" value="P:phytochromobilin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009249">
        <property type="entry name" value="Ferredoxin-dep_bilin_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34557">
        <property type="entry name" value="PHYTOCHROMOBILIN:FERREDOXIN OXIDOREDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34557:SF1">
        <property type="entry name" value="PHYTOCHROMOBILIN:FERREDOXIN OXIDOREDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05996">
        <property type="entry name" value="Fe_bilin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041948559" description="15,16-dihydrobiliverdin:ferredoxin oxidoreductase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1898506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41285" checksum="063E572DBC88F047" modified="2024-05-29" version="1">MMPQHLLLLVPVAAAYTLNGAQPSFVGRSASTRLTSTMVERMETATFNPVSQYEDANTFKNLPIQLEVAPTMTLREAEAEHGMPWKSSIDANVKDDELLYMKFWEWQMSFMEEHLTDLQYEACTNGETDFSYNANAKKKARIVNICASSKEYRKIRMTYYDAGDNTQVFNAVWYPDPEYNLPVLGIDILAFNRKKYLAIVDFQPLHEEESDHDATYEDLLEPIKEKYDTLKGRMSSKFYDETQFFSQQMLFARFDEEKVVHDDLFPAFKSYVKTHVDLVKSTERNPSTKEFVLERQEAYDEYSAERDPATGLFAAMFGAEWANDFVHDFLFSMSEKPDASSIPPAFVGGGGNPHGPPSGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDF8</accession>
    <name>A0AAD2FDF8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RmlD-like substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDF8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="311" mass="35301" checksum="C3794EEDBE6A9FF7" modified="2024-05-29" version="1">MPEMKRVLIFGGKTGWIGQMMGELVKKEEGIELFIADSRIQNREAVAKELDEIKPTHVLNAAGITGRPNIDWCEDNKPATMRTNVIGTLNLADLCDERGIHCTVYATGCIFVYDEKHPEGSGIGFTEEDAPNFDGSFYSQTKGYMEPMLKEYPTCLILRVRMPVSDDLFHRNFVTKIVKYEKVVNIPNSMTILTEMLPASLAMAKKGLTGVYNFTNPGVISHNQVLDLYTKYIDPSYTYTNFTIEEQAKVIKAPRSNNELDTTKLMRDMPEGIVINDIHTAYELCFQRMKENLTKMGWLPDNMPAEFKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEN3</accession>
    <name>A0AAD2FEN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000247">
        <property type="protein sequence ID" value="CAJ1933169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEN3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="420" mass="45552" checksum="1E23641C2D790D24" modified="2024-05-29" version="1">MAYLSLINDNGNLFYLLVHAPAFHKSLPGVPSRCDGKAYAFTGDVVANTITTVEFPQDAFMSPGTGTEENVAKDLGRALDILQLNPDDSSIGPFQDTDANIKQAKTRHYIPLPHRYVHLVLGRQVPVRKGFIDLAAAIKNTGDKIEDLVKKVKAVKLGGNETDDLEEEIHPFSILLPSYGGSHVGVTKAARERAAAYAEVHGGSGASLQYAIALRKPTVHIPETFSKTRSHLMGLLTLWQIRQRSDSWIAALPANYWSSPAAQLPTAPWNGGYLPYMMPPGMVPMSSDSSGASSLTPHSLGYPPFFNGFFPPQGGGIKPGEDDPKSKGKNSLQVKNSTHVPELIQFRKLALATAVPKAEQKAGSPPPEITHNGTKVQMCVGYHVKGKCWEKCPRAADHVAHSAQDTAKLVEWCKKAYAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEW2</accession>
    <name>A0AAD2FEW2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000497">
        <property type="protein sequence ID" value="CAJ1935681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="33130" checksum="4CA220125424FE38" modified="2024-05-29" version="1">MPARNQANQVTIGGVTIMTQATPATDVGVSLVAMKKENRSALDADKKHAFFQLITKHQHTSFDLQPQTMQSVQNLQESYDLGVGLANMQMHFKRYDVLDVFTIVFPSKNAIGEQTGQLETDNFNVTKTVFLFDCYAELTADQVAESCKWYTRWPDATTSPWFRENLSLSYDYLCNHMTSQLWGKVLEDLLLYRDTQGMGGPLVFFFMMKRLQVNSQLVVETIQGQLKTLCIDQYEGESVDDLTLSDPKFNEVFHNKEINAYEQALTQGDAAYGSPDMILDHQHAHQRWVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF46</accession>
    <name>A0AAD2FF46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1898591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1898591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="28945" checksum="C726BCA8706B3D66" modified="2024-05-29" version="1">MISAYRTSIFSVVSTSGRRAYSGTVRSLKSTANRSTLETSGAKVATESAASKSTSSSFVKKHPFKFQLGVATVKTSAADLVAQVVAEQKSFDEIDWRRNGLFVVFGFTYLGCFQYWLMVTKYRHWFPTMDRFAKLSFAAKLKDTAGIMDAMKMVLFDVTIHLPILYFPTYYTVKELVGGKSWNPADWVKDGVTKYTNNAKEDLTAMIQLWGPSDCIQFVLPVHIRLPFRHVVSFFWTTYVSFTRGAMEDDGEKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG85</accession>
    <name>A0AAD2FG85_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS23038</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4978</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000532">
        <property type="protein sequence ID" value="CAJ1935960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1968002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG85"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="3">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="3">
        <location>
            <begin position="83"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1935960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1968002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="356" mass="40120" checksum="F4BB1E4154233A96" modified="2024-05-29" version="1">MTHQSRLDDERWKEYMKELQDFKQKFGHCKVPQKYAKLGQWVHHVRCAQKALQHGKPYSLKLTPPRIAELEAIGFVWGESRPAWNDHVEDLKQFRQQHGHTLVPANFPENTGLSKWVRRVRVAYSLMQQGKFKKGATIKLDESRMKQLKDVGFVWNTKSKNGTPTGSTSGVGGVGTSSDSTGSAGGGATATSNDVAAFVVDGTGHGVGNHDHDHDGEPDPFHHAQSVPPQHQRDNATTIGGVDHRISQGYPLGATARGRSTGGAHNKRRRTDDSSSTTSKLCPEGVRIQEELHLSQERCSQLEEQTREMEHKFKEQQEVAEFRRIQNEGLWDENEKLRREIADLKAGRLVFQHWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGW5</accession>
    <name>A0AAD2FGW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000635">
        <property type="protein sequence ID" value="CAJ1937377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="21666" checksum="3E35D5797DF7B9EE" modified="2024-05-29" version="1">MNGFKSKTYGLILNGMIGKPASAFNWKSEGYKEFLPSVIRNVHATLDAAHKNSVYHLYIRPSNIIVPTTADKMTKDIKVLVIDWGVAISDDKKFHFQGCVPYAHDELLATVRMEKKAKSEHDWASLLYTYYHLDEGHLPWHVLMAHGKRVCDTGVRKNTVSNWLEQKRLQKSEKDEDVFQAFSQLLSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJF4</accession>
    <name>A0AAD2FJF4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJF4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="453" mass="51208" checksum="749FD3745C975AB8" modified="2024-05-29" version="1">MAALADKKDAELARKQLSLLLNIVYSKFQAHKFLLDGGGINIYRLGHFRYHSVGSRYDRALSFVESGFCFLLQVCLSLYVGAEMIDVFILAADDVTWSLQNLPLAIITLFYSGLVFLRDLRDTRQAKATVYNKPSLFLAMDLFINVGLHFFLLLTGFIVIFVQDTFIDAVLNAAALLFIIELDDNLHQILGYSVSDVVENYLVKLSMSDLDGLIEHMDSKDSTFDMTSLNRKAKARLNLEFGDYYLTNQQEQGTIDGTIFQPFKFKSAKMGAKGQDNLGGYMISPNSVVSESCLIKKIEWWYTKYPTTTSPRIEGANSAQDFMDAFKYYALWNISPGATKLLRSRSHEEKKIQRNKEKKKVLAHEVVEHKTRSNIKKLDTKHEEEKIKPALAPTRQSESPRLLNRNMIINLDATNPRYAQSERSGLTAATERLESDGSSNSPTVRVNMAGDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJS3</accession>
    <name>A0AAD2FJS3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS9155</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001302">
        <property type="protein sequence ID" value="CAJ1945008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJS3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="14" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="205"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="468"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1945008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="550" mass="61287" checksum="C24A34D2823F6DB1" modified="2024-05-29" version="1">MANMDKWKSEEMKLTPQTWFGDSAASTHMCNDDTNLYDYDVIREEIKVGSGKTIVATKIGKLKLRVKQTNGKVIMMVLTKVKFVPELWCNLFSLTAAMDKGFDLGNQGRIITVTHGSTTIGFDRIFPTSSGFIMAAEMEQMTAEGAYAVLEAGREISIAKFHEMYAHPGEAIPYNLKLQSKLEKCENCALAKSRQANISKEPVDRSEVPGEELMIDISSVKKKSAGGNKFWLQVMDNASDFIFSMFLKKKSETSAKMIALVKDLNAKGFKVKKIRCDRAGENMKFQDEAKNEGRGLTFEFTAPNTPQRNGRVKRKFATAFGRVRAMMNTARMTETMRGNLWAEAADTATKLDTALVYQRGEQSSHQKFWKREARFARHLRTFGEMAVIKVHTKIKGKLKDRGRTVMFVGYADNSSGDTYKFYDPKTKRISSSRDVSWLNKSYGDWKGIKKTNTLRLTQEILLETVHDNDITQAPTTHTNDANTTAPEPGPIPTAAAPAETATIPAVQLDSGANPQRAPQFGPTPQPATTTTARSMEPSRQISTGQMARSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK79</accession>
    <name>A0AAD2FK79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS10085</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12974">
        <property type="entry name" value="Phosphonate-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041951145" description="guanylate cyclase" evidence="14">
        <location>
            <begin position="27"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="11">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="789"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="16">
        <location>
            <begin position="1205"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="826"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1411"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1415"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1456"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="816"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1945943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1467" mass="163487" checksum="59B00397E5167100" modified="2024-05-29" version="1">MKQITTMTKLRCLLFLLVSQILIVSSQNENLGELWPEGEVNCVQGLRQYNPITQQKVYHVGVHASAGIETAKREFNLTFEEYLNEAVGKRWDPPIEFKMKITDDSIRDWLDNKEDVDFMYTDTGIYSCIGVEIGAKPIATTVARLESRGRNYELDIFGGTMMVLADNDDIGSIEDLKGKVIGAQAFSDFAGAQAQFYMMQKEGINPLIDAKQVIFTGNNEDTIQGILDGRWDVGFVRTGQVERTMDPSTGQLVDPSLVKVIAPRIHITDGGELFPFLHSTPVFPEWPFAAKETVDHVVSEEVGDALMAFKSHAAVGQLIAECQEAATTQAERNICDTSPPEYFDPNVRCDTSRELATLAYNAGLAGFHDGFHSPRSHFHVRTMQQDGGFIIQDAKGNWRCERNSKYYNGIICPDGYYKVSEDIFETQCQAKGRSCQDGYSCYCQPCIQAFEVSVFPWNSEDGSSEFSQDSGCDKMSLCGVVQQRNTAVFRAFDNLRRTNATMVVKSHVGGLEKDILTREVEPFLYEFEFSQPNRGISILEIFVDGEQIPESPIQVQVVDRDCEAAYPGANRIPDARGECICPSGTVEIDGVCASTDAHEVSVYPWVVDGEFTAINITLQSGCEKMSLCGAIPQTKEIRFKAQDNRKRDNATVTALMHIGQEERFLSVVETDPFVYEFGFSHNERGVAILEIFVDEVQIPDSPIRVEITNRDCNNDFPGQRMVPSTIGVCECSDSTIIIGQECVPLGTFAGIMAGIGGLIGCSIVYCYLGYRRRKSDEVWHVNPEELDFSHPVEVIGQGAFGVVLAAEYRGTRVAIKSVIPQQDAVRSRAGSMPSVPDSVVSGSNNSEEVSKSGRNDLEAGGDSPVTSPTSNSLDNSDLSDLWNLPTNRKKSRLLKWLPFQDSMSRSKLNILGHASGASTSNKSLRSRLFFRCDETYQRQQEFKTEMRLLSRLRHPCITTVMGAVMAGDSPMMVMECMENGSLYDLLRNETLYTGGEIIMQIVRDVAQGLRFLHASKPPILHRDLKAKNILIDSRFRAKVADFGLSSKNKRSLTGTPFWMAPEYILGKTEYTPLCDIYAFGMIIYEIYSRKIPYEGQNPRKVLRKVCDPRINYRPQVPDTCPKRMAEIMKKCWSNNSRARPDSKDLDMIFADMGSHEAEPLIDQENTRLRTEVAAGDMLYQVFPKKVADQLKLGQKVEPETHSNVTVFFSDIVRFTDISRTLSAVKVCDMLDRLYLAFDSLANKHEVFKVETIGDAWVGVTNLEENQNSTHAKRIAEFAIDAVAAANNVLIDVDDPSAGSIHIRVGFHSGPVVSNVIGSLNPRYALFGDTMNTASRMESLSTSDRIQCSEASARILKEQAPDFPMRRRGKVAVKGKGHMVAYWIGSSPTRSKSPSSLEGFDNKPVVEFLSDGEVGKKRRFRKHKNKRVNMTGEMEEDPSNSAPNSILKGRGKDRRLSLLSSRSTSFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLE5</accession>
    <name>A0AAD2FLE5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLE5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1940462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="237" mass="26805" checksum="0F9B346B11EA1572" modified="2024-05-29" version="1">MDRDSLVYKAKLAEQAERFDEMVADMKEVGKQPQELSVEERNLLSVAYKNVIGSRRASWRVVTSIEQKGDSDKMEIIKDYKTKIETELVDVCNDILSTIDDSLIPNSSSEEAKVFYYKMKGDYNRYLSEFQTGDTRKESAGAALDAYQSASGIATKDLPPTHPIRLGLALNFSVFHYEILNSPDQACQIAKQAFDDAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSDEDDGKDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLP7</accession>
    <name>A0AAD2FLP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLP7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="79" mass="8960" checksum="E55397225C08E3E5" modified="2024-05-29" version="1">MGAGGWFYVPKVWTPYGGWWSNPTHWKRNTGIAGVGIVCVATMLFSVSAERERRPVAPFRQIPSQSWCKHAKTDDPRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMG6</accession>
    <name>A0AAD2FMG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001491">
        <property type="protein sequence ID" value="CAJ1945761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="207" mass="23661" checksum="A83CC22B61B04017" modified="2024-05-29" version="1">MACTRLDSAKKRRRRRQRYKENQEKKRAAKAKWACPPLAEEERNERRRRKHRRYNEKRKGSQGSFAPPSQDSLQHTTANASISTQQNHRQLIVETVGADEADESDDDDELPDTNAILQASQQSIHVERMEAVMGGPSEPMQEGFRSHQRHHQMLLLAPGTTLSSLVTFETIQTIQIQVSSPKFKHLQGLPRPIIVKLKLSVVLLVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMK0</accession>
    <name>A0AAD2FMK0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1290" mass="144586" checksum="DC7D9628E1EA75C4" modified="2024-05-29" version="1">MGEDANLMEDSTKVNENDNDEDEDVHETINQHETSSKDGPSRDPKFISPSQSDYQRKDNGIIKGYGTIKDLSGSVFNPFSFLTSSEESSDDGNSTENPANQTNRLRNGKRASLVHSKVDASSRSKNGITKSNEESTINSTNPPATKRISTRTGPLNPTNKNTSGEANTARRNGNKQIREASPNGTKERLPKTTTKSVRSSSKTRRNTEAIIRKQPVNGKTKGKLKDPPLYSTGASRSSKRRNGGKDDNDCHDHDTSNTAGSSSSSSSSSSADENIARVPLHTATSTQEDHKEREVLSQKWTRDLDKCQTKKLHSRQSKTADTQSSPRIRKVDDSDDDSDGTENIENETSNEEQSIENKTTTTTTAPASTSSLNNDGVTAAERTPPPVATPSPLEPLLEEYNPFGDDDGSSISSRDTNERDDEMPKTSKVRTKDPQFSHSQQGEPPSPSEQLEEEEEEEYNPFGDSWGDSDSSDYDEQQKAQISQTKSKKRTREQRDSNDASITTTTTKPPPTKTSEQTKGTATEALDRNVMGLASTLVPQSNGIKCTRSLATAGNLKFVRRGGIEDDSATNGGMLVLLSLLTNQKHCILNAQQSKELDQWILKKAKYRAALEREVSNTNIEHWQIISNDARRVASLLVPTSEQDLVQQRIFSEAERRLYGTFVIRTIQEFLKNHEISIDEINHRRQSYMESEAKNTEGLGDGQTSPESGQSGWCDLESQLLEHGYCAEWIDKDGKKLCVFGTVTEYVPTHANDDDEDKEKKGEYLTIEYAEQSRSLLNNNHTQIKNLSILDIQPVNIARAWGGCLLYQEKQGRMQAVNDGSSIPLPIYSPIPNCQETIQRAPFPLCWRVPDLYTRATIWQKSAPNMPCLCLQYSGFQLEFTVRPSTIPNSGNGVFLSITSLLHPPLCTATTTTTTTASISGIQHHKKNLPVFSLAPGEVLDIGVYAPLTSQDETPDYIMLVRSFLQSFWCDSYSMNSRSNEAVFDITHGRGELIPEAKQSILPFVNERNDWETNRAEIELMEDPQGAFHYVLGYRCDDNDNNDDDENDSDTNDAHDLPFRQLADGEPREVFVDYGAQYEMVRLHQGYPRIPMTEEERKQKLDEDEREKLDLMFEFSAKKLQKVICYLHDFVRNTMETLEKRQNRNNNIRERALAAIIVLQARSEQLRPEVVVGSHHHHSPMDHDEINNNRRENRLRQRKEHVCYNLSKTNYDVDDIMDDMTKEDWDTVDSQLQSIVETILPGSSLALLLSSLPQQAAINDGSLLGMACSIVASQVRKSSDDLLESEYIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FN90</accession>
    <name>A0AAD2FN90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="11">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS10988</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FN90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042007531" description="NADH-cytochrome b5 reductase" evidence="12">
        <location>
            <begin position="30"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="54"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1947121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="304" mass="33273" checksum="2CDB1A66C279CC56" modified="2024-05-29" version="1">MLRTSSKECMNNLIFKVFLCFLITTMSKANYQAPSLSGKPIKNLVPPGKCQFTDEFVAVPLLERVAVSPTSSVLRFGLPDTSAPLNLSTCACILAKAKIGGEDVVRPYTPISTNDQVGCFDMLIKDYGENAKMSKLMCEDLKVGETVEFKHIAFNVKIQAPFKPKKICMLVGGTGLTPMVQALHAILGDPDSTTEVVMLYGSKVAEDILGRELIDNWAAENPRFKVVHVLSDEPADSEWKGARGYINADIVTSNFPEPSAGDDLMIFVCGPPPMYNALCGPRDEKELSGLLSELKYTADQVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNT0</accession>
    <name>A0AAD2FNT0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001735">
        <property type="protein sequence ID" value="CAJ1947637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1947637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="191" mass="21583" checksum="F34E634C5B15FFCE" modified="2024-05-29" version="1">MSKRKTGKVPRAQTVSENDSYYAPVSLVQKERGKVAKICPFDASAFLGLLDDDDSDEIADDEEDNIKIHGQKANWDIYYFRSHFVQKEQAKMVQSCPFFAPFLGIPDDSGGAIKSVSDDEEDKAIRKVSSAQAPFPMDLQDAVEDKPFQYYADKFERSPKHTYCNNPTLGDLLLQGKCYLFHQPSVGWQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP82</accession>
    <name>A0AAD2FP82_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042251660" evidence="2">
        <location>
            <begin position="23"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="419" mass="42252" checksum="7420779ABB7577C3" modified="2024-05-29" version="1">MTMTSWTIKTFILLSQVIIVDGQFACSANPACSGLVGDCCPTPNGISLTCCEGSGVISEACVENASCNALGLTGSCCPTAEGVFLDCCSGDTPADTPMGSSADNAAPQCSAHAACSGLSGECCPTQDGVFLECCYSDVALPVAACDAYPACQAAGLTGLCCATAEGVYLECCDGMAQQATQCSAHASCSGLLGECCPTTDGVFLDCCNGGGGGGNDGSQSQTRECSANSECAALGLEGNCCPPDFGSKNLECCHGQQAVSTPSIGQLCSENSACAALGLEGTCCPTVHGVELHCCNSIASSRSLPPVNPPITIKYVTGMPISTPKPSLPSTPAPSTSSPISVSSPLTVAPPIAVTTLELSDPNSDQDGNQPAQLNKEVEDSISSVNQLVGQQSSSSLGKYRNIRQSFGVLMFVAVARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPC4</accession>
    <name>A0AAD2FPC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001739">
        <property type="protein sequence ID" value="CAJ1948081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="886" mass="95620" checksum="3B36F2B532FC265C" modified="2024-05-29" version="1">MQDADETKQESRRPESSRHSERGKQRKSSSRRLPSDRDETKPSRRRSSDRDEAKTSRRRSSDRKEVKPSRRRSADRDETKPSRRPSADRDEADQERKGREVSRDVVEANKESKSSSREKADREAKSRARKPSSTASKSPSKSREQMDRDTKREAKASRSRSVDSNESLSESARDRDSKAKYRVRPNTKASAPGVVQEYNNDEGDRSRRNKESCSSSRHTRAGAVPSSSSASRRMREKMDSDSKPKEPEISLKPEPETTTLAGSLVEGDDAIVATAVDEEEVVQSKEAPPIVPPTTRPEEEPIMTSPPTKPFYCKGAFWIAVLFILAGAGVGIFFATQSKNETAIPANGVAVGPTPEETKTPTTSPSFLPSAFPSSSPTETLIYEPPSEEDCVAVSNGDDLVGQEDLNLQIFNIPMDVVLSTPVDSEIVRGALQERMQEMLMPELIGCASASRRVRGRQPVSSPYTVANGKVLVQSRPDTPCTRNTESNCVHVSVKLDTYVRGSERPFDLVSLILQVLGPEDLLTSKLSLQPPFVQIFIVTVASGTITLAPSSTPTAMFSENPTLFPTESPSTDPTTAPVTFPTTEEPTGSPTDAPSVLATPEPTILPTPVPTTPSPTFAPVVDATPLPTPTPTFGPTEGPTPSPSKTSSVSPSIAQSGMPSSSPSVAESIAPSTTPPTFGPTSEPTEVASNGPTLAPSSNPSVNEPFGNQFTSSTYVLYHTNDFSDPYEFDTREAAAAGCAAIGLDLCPKIAIENGDICAAGWMTDAVGYWISNPRPGCRTTPGFVEWVDREFAGAYCCGRPLYLPRDFSYIYDTREEARAACADEGLVLCTPQQIEGADYCAYGWLDTLWGLWSSGSNPVGCGPRGLNVGDNDGTAGAYCCASNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPJ2</accession>
    <name>A0AAD2FPJ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS11475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001743">
        <property type="protein sequence ID" value="CAJ1948138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051309">
        <property type="entry name" value="ABCF_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42855">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42855:SF1">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="246"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="560"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1948138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="829" mass="92562" checksum="867863326646A91C" modified="2024-05-29" version="1">MGAPSHQSSDRLTILFAKKKKGNANVNAKVAALEALEALEGQVNLDEPMSKKEQKKLEKQKEKDATKKNAKEAALEALDAFETEDIDAPLSLKEQKALAKNQMKVEKKGLVEQDGNETEPGAATKVQMSKKEQMLMKALEMEKLDAEKAAPQEENSEQKLSKKELKALKKKEEKQAAKSAAKAEKKPAKESSSAETEIGSSGDSTGETTPIAAEDKRLTLEDKIRKDRPPPRIRVMESSQPGFVSLRLENVGITFRNQEVLKDVTWGVQSGDRIGLVGKNGAGKTTQLRILSGELEPTTGDVVKSSGSLRTAILRQEFVDELVKERTLKEEFISVFEEENQIIKDLKEVESRLENMFSDDTDKMQEILDRMQELQQKAEDKNVYVLESRVKKIMDLMGFTEDEGEDLVASFSGGWKMRIGLGKVLLQDPNVLLLDEPTNHLDLESVEWMESFLKEQSIPMIIVSHDREFLDQVCTKIVDAEGGICTEYDGNYSRFLQLKKARMESWQAAYDAQEKKIKSERQWINKFKVKQPQAVKQRQAKLDKFLKSDEYVQKPPFVVVGMSHAYNNDISNNRLFENANLLVEKGDRIAVVGPNGCGKSTLLRLLTGKEIPGEGSAQIVGANIVMSYFEQNQADALDLDKTVLETIQGASDGQSYNELRALLGQFLFKGDDVEKKVLNLSGGEKARLSLCCMMLNSANLLILDEPTNHLDIPAKEMLEEALQHFAGSVIVVSHDRYFISKVATTIVAIEDKNLFKYQGDYKTYMNASKDRKEKIESRYVPGADKIGSAPVVDLEELTKPKRNFGGAKTAGMVTRKNKGVKNAKRARPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ35</accession>
    <name>A0AAD2FQ35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1948913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ35"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041951147" description="VWFD domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="62092" checksum="E1B4B0E4B6ECD2E8" modified="2024-05-29" version="1">MKIYFSIVLSAAIFANVANAQSLFDYSAPATGSAKCALINVIMDESGSMGGDQTFLKNVALPKMATELHSSNHNYSDVFVCSSGFGYSRTNNAQAYRHLGCTTYNSAGVIANSTALAWYANGAIEDGWYAMKHGMQDVPSSINGTDLLSHCARVDKNLILVTDEDRDDAYSNVDATNIANLIDTNGYILNVIANYGINNNINDFGMNIGGGGSNSTIFRFDSSAPDNHMTYQDFRPYETYVTSFGGTHPHYTELIVDKPGAAWNINSLRSGGLRAQTFADIFVDIKVKEISNGTGGPSGGGGTVRVGGPEAGGDPHITTWNHKEHYEYHGQCDLVMVKDPTFADGLGLYVHIRTKIVRYWSYIQSVAIRIDDDVLEIEGSADAHDDQAHYWKNFEYQGDLDTFAGFPVTQKLPSVYKRTYTIDLSSKFPGQEITIQLYKEFVRVKLNGNEQVFGNSVGLLGDYKTGKTLARDGVTVLDDFTDLGDEWQVLPSEPTLFHEIAHPQFPELCLKPEDPRGERKRRLEESSISEEDAEKACVSLKDPLAIKDCVYDVLATQDVDMVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQB2</accession>
    <name>A0AAD2FQB2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQB2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="743"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="924"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="954"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1948509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1250" mass="138427" checksum="2DD724603EE60EFC" modified="2024-05-29" version="1">MDQSNEEKTQAASKGTAEKKSHHRRQSSTITDEDIDTMSQASNSPPLPPASATLTPNSHPQSPSLYISPASSSGKSPMLTIDTVPRRRSSQKTSSDFFIPYDSDASGGSFVHDKSSKSDLASTTSSGYGSAGSSSRPKQHKQHNRFASFDSNASSGSVRFISPRSQPKPTVNPHLLPYHERKKLQKLQQQQQQQQQPPNQQQQQQQQQQQQQQHQQNPKQPPNQQRVPQQGPFPPNMMMMMPPPPPIPGQLQMDPQAAAAAFYGMYGYPPPGAPGFPPPPPIQHQHQQHHQLHSPQQQHPPQHAGFPPGFMMPPPPPISAGGQQQQQRGGPPPFLQPYPMPFYPPPNLPQVFPQHQHPPHPPQPQQQRRSSQTSISSRDRISTASLPKSRPHHVRTDSHGSMSSLGSTGGGSDSEHQQHQQQRGSSPSSHRRNSTSSNNSGLASAAAGIVAKNHNNPAPISPYRSSSSKPRLFVPGVDSPSRSRLSSQDSRPPASRGTHKRLASINNDEWGTNEKDDNNNGVAPNADAAAASSEDLGTIDGGGGGKYGTTSMMVDENSSYSGYSSSSDTNSEDDVNEKTSLLPPSGISTNEQEATNNLRKDSRTSGGKYYGRRSSETDAKNKSSSKRNSGSDVALDRHKKSVRKSRRKMKKSRRRAAAAAAGNEDDSDTSDSSYDYRRWTMKRARMLEKEREQVHQQWKAEYLAKTEREREQKEYQRLHRRCFRWFASFGSKGYRFITNINMFIANLPAAIGAVAMAFATLGIVWFKFTEENLQTCERVHFHSSQCTFPEFPGCFYCDTTVPMYKVAVNFHFGCNVVAGTLALMFVAKVVVATRAVIDEMASPVTASPAGLLCMTTVCVFAGRGLIGQVMVSLAATVHLGLVIWYIYIALAYQIMPEPTWFPNTIGIGLTAVKTWLYYPMPGHLLMAISLSLNIFFFPISLIRVAINEKISATVGWMQMSAPALSLYALTIMAQPSFEEENPDVTNFQRVHRMIYLPCMHFMCALSLIGFFASCHSLWSRWDDLKKRPFSPAHSAFCFPTLSHANAIQSYRGAVLTFSEVKPHDWRLIILYAYWFVVLLGGTVATLWISSKFLYNLPAWTNMDLADEEEPPAPSETILSLQEMITAGETMRQPFVSPAVLQANETGALVLTRTGPEGELRYVRTRRLLALGFEPTMRWSEMQKEREVLLEWVGKNPPRRRNRTLSVPGIDFSYGSSSSSAFGTDNRGIYGGYGSFSPLPPARHSRADTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQC9</accession>
    <name>A0AAD2FQC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQC9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="19640" checksum="2FEC20A56D1BE52F" modified="2024-05-29" version="1">MPRFNEEIALEPDEDLFATIIDFQSNAEINASKPCSTPAPVSNDDESISDTSTFSALSFLDPAGEEELSIEDSGDSPPPVEHMLSKLNSMMMRSNLSRAIISKNVFPDFSIKETKISFDYYPPNSPTGTTKSNFHKASPSASKHTRRTHDKISTDFVRLGSRQDSSIGEFLRASKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQK4</accession>
    <name>A0AAD2FQK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DIS3-like exonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS12131</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF30">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="16">
        <location>
            <begin position="487"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1102"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1206"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1102"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1213"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1230"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1949508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1245" mass="140129" checksum="E631B6417A24E3E4" modified="2024-05-29" version="1">MTPSLERTSKVLEEDRLWIYRDFVKEKLRNRERYWRPTTDLPVFVGKESSGSCWVVPDGIIWRKYLPFLSHLVKESQCNLLLLESAVDLMDYRSISPVIECNVENDSDCTWQPEKPAPQERSKIAKLATLFSGRVFPFCDLSIREEDGHDEFDMMDYKSISIVDRSQHALMRTAGLLRQKIGNNKKIIIVSTQDLKAKYPSEDGFQLLQMDNFITELLALHPHLNEEVLMNLKRSCEEEYKVRNMARSKSVESNSREFLSEDQVREGLKTKTLFKGRLEVSKHNPKEGTVATSDGGKYFIDQKLGYFNRSFHHDVVVIEVLPKTEWGSPVGKRRLVHHRDDDDETDTTSFDVDSAPPVPSARVVAISESSRRRFVATMVDSPMNDDSACIVTPMDIRIPKIRIKTNGWNRFVGQRLLIQVDSWDIDSNYPAGHCHEIVGPIGDLETEISCLLHEHELHLEPFSAGALACLPSEGSDWKIPPEEIEKRRDLRESYRIFSVDPPGCQDIDDTMHARELPNGDIEIGVHIADVTHFVPHNSPLDLEAQVRATTFYLVDRRFDMLPSLLSSDLCSLHGSTDRLAVSTIWIFSRDFKEVKSFWYGRTVIHNCQAMTYGQAHNIIHDQPPDEGNRIPPPLTAGAPVDPANVKNLKKDLTILTRLARKLRKDREDVGGAVDLSSGDQGNELKFTLDKDSNPIQVTAKKQMEIHNTIAELMILSNTWVAKTIYDKSPDSALLRNHRSVEDSRFEDLKAVLDAGKIAFDGKDNMALANSLKAAETATKLNSTMQSLFQSLATRAMSEAQYVCTGQVGKDQLSHYGLGLQKYTHFTSPIRRYADVVVHKQLLSAAAPPGNHSDASTVKSRTEVDNALVPDSKTISILAGEGIRTRDETIETPDETEPNDNVVVTESQEPPELENEFSVERVYSPRLVAKICDILNRQNRMAKLSSMECQHLFLSIYFRKHVEVTKAVVVDLRANGLWVYVPLFDMRGPVYLSDTNGRVQVDPRLLGLDPSTGEDPTLAFEASPYARMIPSSDCMLVESPDRHLKVTAPKAKSPYTLRVLDVVTVQISCDSWDVRSRIPMPKIHLIADSSGKKISFNAYGQTSKSPITSSTLQESQDDTNEGPVEANPQEWASMYSELAKLETPPVLVEMQFTSNIRKAKSDACSISVIPGRMVFGGFRNLDTRSALQEAAIDEAAESAEQRRAQALAGAARSSEYDTTRRIEKDITSRMQRLKANKRNTRKAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRS0</accession>
    <name>A0AAD2FRS0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001779">
        <property type="protein sequence ID" value="CAJ1951076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="183" mass="21572" checksum="4F66E78253129130" modified="2024-05-29" version="1">MIWSVRNMAHVDFKALRGTQTVYKPGKNDSKFFKSSRQAQLDRNWENLNIKIDKREVIYTTNQYTVAAIITKHFITQAMRDKLSNETDWLDLKEDHVMLLKRIKTFMTIMDEDVLPKGCHCPVVQHLSLHWWMMTWQNLCRQPSATSLVVQVNHLVPIPVQAQKNLFILTKDAWWTQSNFALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUL3</accession>
    <name>A0AAD2FUL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA alkylation repair enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUL3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07064">
        <property type="entry name" value="AlkD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.290">
        <property type="entry name" value="ARM repeat domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1660.10">
        <property type="entry name" value="Hypothetical protein (EF3068)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34070">
        <property type="entry name" value="ARMADILLO-TYPE FOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34070:SF1">
        <property type="entry name" value="DNA ALKYLATION REPAIR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="25396" checksum="EC80E6D56A994886" modified="2024-05-29" version="1">MHKIQNKQKGAEMKKYLKDHFSCLGIQRPARNTIQKPWLAVIKADFQVDPWDLAWELWEQEHREFQHVAIDYMKTFPKKSYKKDDHIKIERFITSKSWWDTVDFLASHVAGNYFQNCPEMIESVITKWRHSDDMWLNRTSLLFQLRYKETTDFELLKGLVLQYLEVKEFFIQKAIGWSLRQYSRTNPDAVRDFIADLELSTVARREAIKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUY7</accession>
    <name>A0AAD2FUY7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001816">
        <property type="protein sequence ID" value="CAJ1953074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="266" mass="29241" checksum="D13A834AD7C18D49" modified="2024-05-29" version="1">MLHYIGPMPGASQLESGISGGSIYVDRVVQESAVDGLVQDQLPDDAILLCLGTNHAALKNELVDKMKSPSCLVKILLPLLVSTIGSKSPATFVQAGIESVREGPDSPMAFISGADQWMRQYSARMVAMLPRSVRHEMLSLCVYTEYESIFTVRNKIEPVCSELKKIIHFTWKAFGLIHGFVDERAPLQVPKYLYMLSLQNGENLVDGSPELLQYTSFCFFESSESLKGAYAIGSTLATILYICRLGSLGEAFKCNGNNYIGRQLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV73</accession>
    <name>A0AAD2FV73_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV73"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="325" mass="36415" checksum="4906F0912737B06D" modified="2024-05-29" version="1">MSRWAKQVSRMGRDGFQLASAIFKDSTTKRAVSFKPVLLDQARQYNLVARSLLQVDRQIGLVRYHGIMGYFQQQWQARFSSSLPPSTTTPEGSSPADTSQPNKARIAFMITGSMKQELNEQMGYLDEDIRKMTPLQASLILHYRIIPDEMEEKLPVVEAEYEKQREEDAVKQQQEAEERERLRAAQQVEMKKAEALRKEQAASTAESKTEVNAQQETPSAPYVAPAPLTVASFSAAANNFQSSNTLLSPSADGTTNGFGDSWFEVNEIDPKTGEATRVGLYQEEEEATLGMKTRQEIADAKETNLTFELKPVEKSALFSSSQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVA5</accession>
    <name>A0AAD2FVA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-asparaginase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="164" mass="18153" checksum="CFDD4E791198048C" modified="2024-05-29" version="1">MKILFIQTGGTIDKDYPRSKGGYAFEFGEPATKRLLERLGPSFSYEVVTAFQKDSLEVTDADREILASLIEEHSEERIIITHGTDTMIETAKFLASRESLAGTRRIVLTGSMRPERFSNTDAPLNVGSAMAAVQILPKTGVYVTMHGVVREAHEAKRDDSGQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY22</accession>
    <name>A0AAD2FY22_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001907">
        <property type="protein sequence ID" value="CAJ1956211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY22"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041971704" evidence="3">
        <location>
            <begin position="27"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1956211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="296" mass="31934" checksum="09907318B3056E4F" modified="2024-05-29" version="1">MSRISFKHTTLLRLLLLHSLQAIASSSHESVASSSRRAPPNVIVVGGSSGMGKAAALCTVEKGGKCLLISRSKEKLLTAQQYLVEQVEGADVDIAILDMTDEEAVERFAKEDLNDNEWDGLVISAAGKAPHGPMMKLATSESRSMMESKFWGAYNCAKYFAPKLTHGGCVVLVAGILNRRPGLNCVPLAIANGALEALTKSLALEWGPRLRVNCLSPGFCDTERFDHLTAERKQKMLANTAASLPLQRVGEPKDMGEAIYYLLTAPFATGVILDVDGGHGIRQYASMTNDPMRKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYJ9</accession>
    <name>A0AAD2FYJ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001929">
        <property type="protein sequence ID" value="CAJ1956975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="342" mass="39987" checksum="1175B28D43626D2D" modified="2024-05-29" version="1">MLDTTAVRRYLQLVHKGYEAYSIPSRLASLHHQLQLNEGTMTATMGRHYNCLHHQMYVVRRKAEEKCRWVTNGSVPWSPKMQQFWDCQSLWKILLKGRKGCRVSLRKIRRLMKKVGIPDAWTKTTTELEAALRQDRKDYLEAKTHYAAKWRKDFLTVQAAQSKKKQWRSQKARDRFLRLRRMKQREEARRRRRAQAKGSTGGLHAIQVEERLPSGEVGLRTVSERSQVEQGCMQENCARYDQTRLPHMTPPMDAPLYQMFNGHDAEQNSLALLEGRLPLPDGIKNPTRSFLSQCRFHKDHSMSLLEVSTEYHTYFWSRNPEHKGSEPHACIMATLKLGFSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZG8</accession>
    <name>A0AAD2FZG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001959">
        <property type="protein sequence ID" value="CAJ1958006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZG8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="2">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EIF3F/CSN6-like C-terminal" evidence="3">
        <location>
            <begin position="181"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1958006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34891" checksum="03AE2F9E0A0ED9F0" modified="2024-05-29" version="1">MSSMEVDQPKGAAIKESGVALHPLALVHMSDQYTRISTGGSPLDKSAAVVGLMYGFTDGQGVLQIQDADDIPPEASEQTQLQVDLHKAVFPLHSVVGWYRVSLKDEEPSPDDLQTTKNLSEHFANSLAQFCFCLLEVQQDTKDTTGSSLNEVLPINLYTLREVENHSILLGFDNWNLETSDPERIAVERVMKERPMQAEGSRASNSYVESSNSIQTSLDSMRDRINVLVSFLRSTQEGKVPMNHRLLRQVQVLVHSLGPIAQIAGSEAPSEASDADIMTHLAAVAKTVSAVQSYTEKFRLIHENRNLNKEMRRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZQ7</accession>
    <name>A0AAD2FZQ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001965">
        <property type="protein sequence ID" value="CAJ1958063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="346" mass="39697" checksum="9D333A3937575FAF" modified="2024-05-29" version="1">MKADYEEHGAILIARCMMQIKAKFDTDEVLNFIQQCDINQGLKKFGDDGKDAVDEELRQILLRDCFTPEFVKDMTASERKKAQSAMMLLAEKQFEKTIKGRLVYRGDGTREWLSQEDTASPTALQEAIITTCVIDAHEGRDVMMLDVPIYTRITGMMVQILIDMAPEYCKYVVLENGKRVIYVRVLRAIHGMLQSSLLFYNQFRSDLEAKGFVFNPYDPCVANKVVDEKQQTIRFHVDDLMSSHMDPKRKDTQISWNDFGFLGEKKLKIRMDDYVKNMLEDFPIKFNEDSKQETPAGNDLLQAGKGNLLSAEYRQVFHTTVARGLDVSERACFDIHPTITILASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZZ6</accession>
    <name>A0AAD2FZZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS17243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042228019" description="ABC transporter domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="27"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1958572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="662" mass="72558" checksum="C95550F4831C6617" modified="2024-05-29" version="1">MMMWRDSFWLFLLPFCLRAGVASCDELYPSGLYWNISVQSADGTFLVQPTAHFLFVPNGHICGVLGPSGAGKSTTLNALGGSIPPQSSLSVNGNITYYDATSETKTTGTINSGSVAWLQQHDSFFSMLTVKETLDMAAFLELPHLIESQRNARVQSIMESLGLTKLQDRPIGDPTTRHKGGLSGGEQRRVSLARELISNPKLFIGDEPTSGLDSTMSEKVIRLVQKMVQERDIPCLLSIHQPRSSIFRMLDEVLLLAPGGRVCYHGKSEKAIGYFRNLGYECPEETNPAEFLVDLVSIDVEDQSTSIQDEIRIIKLFEAFQEYQQKRRHKLSSMPPITAVAVEDCSTTSSRGSRRRFHIIRRFGRLLLRSWRQNARNRKVNILRLLASAGNAMLFTTIFKSIKKGVFTAKSVAERVSMLTFGIVNMSMIALLKTVDLFSKEKPVVQREQLRLQYSSLEYLFSKSIAEIPLDAAFAAVFTTVLKMTSGIRTGWRALTGTFALMTVAGASLGFAIGAASPSADVALSSSAMIMVVMMAVGIINPSGVDLSDPPPLLVRALKQISPINYAVKALCLSEYKDAEFGIDTGGKPVNIFSRARIMMRDLPKMGGLALVKNGNQVLQELGLADETYAGVMKQLGVLSLVNLAISLIGLQTKNSGLSQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G019</accession>
    <name>A0AAD2G019_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001895">
        <property type="protein sequence ID" value="CAJ1955804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G019"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042050568" description="ATP-dependent Clp protease proteolytic subunit" evidence="4">
        <location>
            <begin position="21"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1955804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="313" mass="34958" checksum="CBA0FC2F4C99041F" modified="2024-05-29" version="1">MTGFFSKAIAMLCLLSSTEALSLNSHNMPGMSLSDSYMLTQKRTTRMATRRDTIMMPSQTPMVPWKAPGSDVAQFVDINSAMYRDRTIMINKFIDEEAANEIISIILYMRKEDYKGDISIYFNVPGALLRPTLAIYDLLQQTKQNCEIETVNLGLCAGMASFLAAAGTKGKRSAMPNSRFLLQRTGMDEVFRGQATDIALEVRNVKKSNDRMEYELSQLTGQPVEKIHQDLTRDFYLTSDEAVQYGLIDKVLLPAPLKRAARGQDADLGTFEGDEEQKYQGQDSSGGWGSQQAQQRSEKPKNDDDDGPKIMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1R4</accession>
    <name>A0AAD2G1R4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002022">
        <property type="protein sequence ID" value="CAJ1959785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1R4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="102" mass="11911" checksum="40F13B660EDF2B71" modified="2024-05-29" version="1">MWIRRSHILAPLNGVKWHWGQVEQQAFNNIKRVMAKETLLHYPDFNKPFEIHTDASKYETGAVITQDPKPIAFYSRKLRDGQHNYTTTERELLATNSLGTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2W6</accession>
    <name>A0AAD2G2W6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS18912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002073">
        <property type="protein sequence ID" value="CAJ1960831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2W6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00769">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187:SF1">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1960831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="529" mass="57985" checksum="A5976B7DD7C9EFF7" modified="2024-05-29" version="1">MSTNLQLRPASRRTLAAKPGRIRGGETVTSNSEKLDVSPLEKVRNAIFPIYGKQEVTKFLLIGSIKFFIIMALTLTRDTKDTLVVTQCGAEAIAFLKIYGVLPAATAFIAGYSKASNVLGKKTLFYFTAIPFFLFFIFFDLFLHPNAERLQPSLVAVQSFLPGDSTTGGMEVMAKIFANWTSALFYILAEIYSSVSVGLLFWQFANDVVPIDQAKRFYPLFAQMGGLAPVIAGQYVVWFASKAENLGSSLHRLTAAVTFSGVMICVLYHLTSSFIERTESYAQKTESSLDGQDGKKEKMSIAESAKFLASSQYLRLIATLVLGYGLSINFTEIIWKSLVKKQYPDPLDYQRFMGNFSSAVGLATCIVIFFGVHVIRLLGWRVGAMATPGIMAVLAIPFFGCIILGLDNLDRLKWAVILGTIQSLLSKTSKYALFDPTTQMAYIPLDQESKVKGKAAIDVLGSRIGKSGGSLIQQGLVFGFGDIISAAPIVGMVFYSVLLVWIQAASKLGVLFHAQTEMKKASDAERKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4W9</accession>
    <name>A0AAD2G4W9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002124">
        <property type="protein sequence ID" value="CAJ1962824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4W9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="133" mass="13977" checksum="19E15EB66CE3366B" modified="2024-05-29" version="1">MPTTRSGTNSEPSPTAGAANQWVSPATLTVGTTVGTPANTTVQPGDTFASLEFAVTTLFRASLDSPLMLARCCDGCINSMDLLSYSEAELLELKYNAPILDAQGVDTGQTQLTQLGQPHCGTLWALLGYAYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6X3</accession>
    <name>A0AAD2G6X3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein xylosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6X3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042220798" description="Protein xylosyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="955" mass="108191" checksum="98F51593ED95D0F9" modified="2024-05-29" version="1">MKYGAWTSRIKLLSLLVLILLLLLHQLRGSFLLQQTTINTTWILQEDAINAPTFSDSDERLTLVHCVGENFLPGSSWHSKSCHYRNLCYHDQQQWTLRPSSTLQLELEEENNFFFFSSTKLQQNVSTIGLRPSWVRNKQYRWSPNLDVTNNADRDTIRKTVRKHVDRTVIIVSVPPFGSMITFLVDLLFPIFNLIELFHLQSSTFDKPILVNLLNIQDLNDDDIAWMEKGLSWMGYELMYRNISSLTTNLSSSSSQIPYCFSHAAAGIGMLTVTGLSQRGALATDYQPAWSRNHAGRGVLLHQFRNHVLRHTLTKKKKEKENLEDSSSRKKMIQLAFTATTRDNWKDLSKCLDDTVATTQNSYSIRHIDWTSHGRMNNTVDLMETAASSYAWIADANNENCTWPALFLPKGAHLILLYDSNVLVKNKKKRNKNSNGGNGRPIKLDFGLWNQLSHIHVHWLSLSHPPVTLANMMAGILLNNNISGNDTIKSDTQDGTRQIHSDSSTKVRFDGGMPLSLKTRHMPEGSSKVHCIGENWMWNAAHYRSCHVQHLCFDTVSKTFVLPATATHNNNGRLLPMDAVSTWVDPQTTKVMMGHSIRHSTSEDAWFPLLQSSSSPNKDYSYYALDPNVIWLPFFSEQPNISNPGHLLWDFWLPMFTLMELFLPKDGGRPKLLLTNLDSSCTKGAIDASCYKMVSKFLPLLGVSNDSLVSAMVESQLWDPTTDVPEHPTPLVCAENGLMGIGMLTDHGSKKHGQLLEDYQSVQNIGRGPMFWRFRNFMLKNLKQEESSGRPAAPWKITFSINSSQNPSRRRAMERQIEIAQELFPPDGNELGIVVESVQLGQLALEAQTKLMDETAVFVSVMGGSASTAMFLRRDTSLILYYNDIDDFAKGNPNKGGNSIPNRMDWDFWNNASYLRVHWLPIRTMDAENDLKSFARLLQVEVNTAMLLAQEQSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7D3</accession>
    <name>A0AAD2G7D3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002204">
        <property type="protein sequence ID" value="CAJ1965608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7D3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="154" mass="17499" checksum="F1CC13F74E16F67F" modified="2024-05-29" version="1">MARIAFSQFFTVRGLPRLILIDEGSENKDQFTALCDTIGIAYHTVSPENHDGMLCERFHKYLNKVQRIGAADMNTYKEWAMNTMFGTYAWNAAPVDGTDIQRAFAAVARHFKFPLDNAAAALSISEARQKNRTRHQQTPGQNTLEHIETMFPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7K1</accession>
    <name>A0AAD2G7K1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7K1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="438" mass="48514" checksum="3FA92D4450645C9C" modified="2024-05-29" version="1">MGNSSSQTANEKRQEEVRQKFGVLVPPSFIVVDPSSDPTASLPISCQTRLKSIAAPNVLNDLWTMNQGRQLLETYMTPGVTLSVPTATQGQILVALNTTEGDKSSFLWAEQPLSDNAKAELLVPTVDSPHFHMRYKQDINENTFWAVRGQVNTQQKGWVESRLKSTYDDLDILFSVSSSLPSPSKDATRKDDIMDQVLNSVHLQAAAEYKESLVAVQGGLDQNQLPTLTGSMVSLNLNHQASDKNNAAIDGDVNARVPPLWLTLKQLKPSGEDTTKWTLNLSQILTFDRYVWNVMEERAPKVRQILGWSLQMDTTTASNDAESSSSTPETKWSIGTTWQVNRGLAFKGVMTTSNTSPLSLNYGFIVKRWMQPRATLSVLSQFEFATKKSSFLGFGLELEASPFTLNSTTPTYPNSPSPDYAKADEAAPTKVFIPERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7K4</accession>
    <name>A0AAD2G7K4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7K4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="748" mass="81101" checksum="F728FA78589B8C3A" modified="2024-05-29" version="1">MPVIAPPSYEQNKRAGSALENAAEELLNGIFCHYEPPTSTKAQKNAANAIRNNPTKFLYEEQPIKLVPKKKKVAKAATTPMSDAESVGSEYYESGTEAGDYEDEASLEGDDMEDLDEETKLLKVDTSSKRGIKWRDEESKRVETEKAQAKAASRWSQCVTLPCFTSDGHDIPGTLEDIHDENEAPQEPTPVAIATPSKSALKKRDDGVMRVLYDDQGNPNTTPRSPGSIKNHSFFRNVTNSPRAKSVVGVGGIGMYEPSDYNKPSTPKATGFKMPRDYTPRVPRGPPAPPSDVGAPSPKAVSVPPSPAAVPSPAAVPSPAASPAAVRRRQVPISPMKVASLPGSPGVSDYNFAQAVAPPSPRVRQIGLLAGSPGIKDQKGGPEVIRLSKIGRTPSGAVPQPVNTVAPGQFVAWSGVDPSTTQPGNYVAKSPKSYMAPVAPVAPVSPVAPPPYADIEEPEQMSVLQAVQMLNKAGFNPGKRFNRGFSAKSFRKAKAPPKSPSVHHHGYATANDNRDSFDREQKPAFVGTRRVAAPTSLVQSLNNNNTALLNEIRYSNRAPVAPLELNIDMRDELEMTRDPTPRQLKIQQLEDNLYRPNGPLPPTPRRREQEPEFATRPTPTAQKPPQHFVPVGNTNDMERTAAPKEAKSSQKNKKEKEQEVTAPVPAKEEKPKEETAPKRSVEKKTQSKPSQSRSAKSSSRPTQSKKEKKGFMSGIKKGLGKLKNTVNEIDSQRIAEPTNSKKKSGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G835</accession>
    <name>A0AAD2G835_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002251">
        <property type="protein sequence ID" value="CAJ1966075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G835"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="143" mass="15995" checksum="F0BC702EBFA70875" modified="2024-05-29" version="1" fragment="single">LCVRIFMGVTIDPAAAGDHEPTAERNNRTLKERVRVAPARLPYKVVPKVITECLGRQAPELLNVFPQKDSISLHFSLQQLIDNVNINYKSDMVAELGQYVHAIGTDSNNLMEPQSIEAIYIEPTKGQCTGHRVLNLNTREICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8Q0</accession>
    <name>A0AAD2G8Q0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8Q0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051441">
        <property type="entry name" value="SelW_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15124:SF27">
        <property type="entry name" value="MIGRATION AND INVASION ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15124">
        <property type="entry name" value="SELENOPROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="981" mass="105245" checksum="B6D06246D5F2B71C" modified="2024-05-29" version="1">MSSPQAEPPDKIKEVEADLVGNIEDGDSRYGKHKSKQTSSSRRTLTRSPQSKSSRQKSSRHLRSPHSKSRSSRRSILGESTKDLHFHDARDADKKERGKLPREGLHRKHNQHNRGLKESYRHASTKSAMSKSSAAIDTLYGDEADSKAKAKSSRGSPARVRAPGVEHVLTPSSSNNDDIVSALYGSDSDTKAKASGRNFVPAVVPGVEYEYSHRSTAIKSPTSSKSNRAINTLYGSDADVKSKAKSSRGLASGNYPGMKQYNSPTATNRSTASTMSNTTINTLYGSDAESKARTKGSRGGAEPASVPGVEYLHSPPANILSTGGSARSNATINTLYGDDSDAKARARRPKGGGDLSQPSGIEGVNHQMSTSLADSMFSTSATDFQLAGDDNAARRAKRRMSNGSAHSYSSNHLDPERKTTVSTTAGGSLSFDGISCRMPNDPEAAPDTDRNNLTVEEKPRKSRKKRIACFLLLLLLIAGGAAAWFFLFRNNSQIKSLGIQDPTPSAPSLSNKTTLSPSTPLFTEYPSALPTSPPTVKQLYERPSESDCQSIARNQTIQGRETMETADFGLDVEVVLFDGSNITESLVQELLDAIQEKILPSLAGCSVIVDELLEAWRFVIFDAFVKGNAARDEKCQDRELMTKNCHRVYVELALFLKGKVRFLDIIGLISDGTLNLSNHLGLSDPFLVVNLFAARGSTAAPTSVPSDMPSLIPTQLPSVKPSTNPTNVPSIEPTVAPIGEPSGFPTRIPSLQPSMNLTARPTDVPSENPSFSPTGGLSFSPTGASSFSPTRALTVSPTLNPTRNPTPNPTPNPTSRPTPLPSPAPTPQPTPAIAVITQANGPYTNYPVSQSSTSWGGVAMRAIDGNNSGLFWESSISHTESGPNEWWQVDLATGAGRPVVVDYITVWNRNERNYALRLAGSIVHLLDANQNDITPLSASNVLTDAREITVNFGMVPNVGFVKISQNGILALAEVEVYGYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAG1</accession>
    <name>A0AAD2GAG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">allantoinase</fullName>
            <ecNumber evidence="5">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS22311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="3"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1966728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="409" mass="45036" checksum="A8C2D623A4ABC4D0" modified="2024-05-29" version="1">MVLSPGLIDVHTHISALGRNWEGYETATMAAAAGGITTLMGMPLNSLPSTTTLDAVEMERDAAASGPLYVDVGLWGGVVPENCHNIKELLESPYIFGLKAFLAPLPPAAGYQAVSPEQLKEAAKVCGPIGKPILVHSELMTEDESVGAVKKAFAKQSPTSYEAHLASRPAKWEQDAVRVVCDASKDCHMHIVHLSDARGCLPIIQACKESPQNTLTVETCPHYLLLDESLIQNGEVLVKCFPPIRDKENRELLWQGLLEGIIDMVASDHSPCEPHMRNMESGDIETAWGGLSGLQYQLQATWTDAKRRNFTPDEMAAWWSERPAILAGLGRKKGQIKPGQQADFCWWDPNHREAPNAYSKEYHRWKGTTYFAKNDSMCGRVLGTWVRGQLVYDGEKDEHVEPAGVMMTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB25</accession>
    <name>A0AAD2GB25_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS22629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB25"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="323"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1967134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="467" mass="51635" checksum="40C2765247831170" modified="2024-05-29" version="1">MVSETRPIIIAGAGPCGLVTALVLQNHGIPFLILEKTSRSKLCSDTGAGFDLAPTALNILIHRLGLSKERIDETLSRYERWYIATIHGDLVKDEGTPQSALEDCACTHRSALQQALLDQLLQNATTEETEFLKCNSSLEYYQEEEDQVKAVMNDGSILVGKALLGCDGINSKVRSCMNEHREDPLQYLGTMCYWGKCPREEVEKYSSAHKSNSSTFVWLLGTNKVPGSLFITPSNGTYRYLWFLSVPSGKPLSGTLDDLTRRGGAVLSEMAKTELLNTLDENGALDPVLKTVISGTPAGEITEAGLFDRVNLDLPFSSPRKLVALLGDSAHPQSPYLGQGTNCAITDAYFLATKLAGVSAQEAITYYDSDQRREEMKNLIEKARQQGNFLNSKNRFECWILRTILRYAPIDVDELKRYDFSNKNMLSRLDGIKAKSSDGGAMTKPILIAAFVVAVFAIGLRMFLQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBD9</accession>
    <name>A0AAD2GBD9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002402">
        <property type="protein sequence ID" value="CAJ1968742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBD9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF187">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="380" mass="42973" checksum="F827BDE8E0073CCB" modified="2024-05-29" version="1">MDQGQDYLLGRLVNQAKEAIAKACIQIPLPPMDDHHDVIDDDDDDESGNEFREVTPIIVASDFDETYELSVCPETGRQIIEYLDLSEFEIRFTPEELFEFDTMLQSLHFSRCHALAKVSPSIRKLKGLTQLDLPRCTSLTQLPDEIFVSLTQLSRLTLTHCSNLQDLPRDWSGMRNLTSLYLEGCTSLKEIPNALWDECHNLVYLGLARLKCINPCLPDGIRNLTELKALNVRGCPYLKYFTNNDNDNDDSKDNALAPLTRLHSIFASNTPISKLPPLSVLAGFPRLKVLDLKNSPNIPLAFQDEQKFDSMGMIRLLDRTRLQAGTLELVLWKTWGWSIDPDERAENRLSIVGMDAVIQSVVPFLCGEDGPELLTFCCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBJ9</accession>
    <name>A0AAD2GBJ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002414">
        <property type="protein sequence ID" value="CAJ1968963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="112" mass="12773" checksum="1F26D3A298929A2E" modified="2024-05-29" version="1">MLCIVNGHPRFTVQSVAKQVEQKVKCYDKYDKANDAEAKIFLGNSLDPELAAKLYLKVKTTDPFPIMFQKFIPMLHTTSIHYFEGLKTNIRKRKSSQYSGEDIAQMAEDVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBN1</accession>
    <name>A0AAD2GBN1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002418">
        <property type="protein sequence ID" value="CAJ1968994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="147" mass="16757" checksum="D1D15838C0CA69DC" modified="2024-05-29" version="1">MEARSAMHILNAPSTKSLKYAIQSGLIKNCPITEEAINHAEAIFGPDASTLKGKSTRPTPKKTYDDFFSPPEELYQHNRSITVCIDHMEIENAKFLTCIDTTVHYRSCIPMQNLKTDPVFEALDKIFRRYNKAGFQVKIIKCDRMIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBX3</accession>
    <name>A0AAD2GBX3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="260" mass="28534" checksum="F8029A9D5762D08E" modified="2024-05-29" version="1">MQVNTKLEAEYSLHGSSSGRRLTTTSLNEKLNTEKVKETSTDETLRGQAEKRIIDFVGDQVTPRQLLGSLRVLKAVTTCFLVLTLLANLMYIIFVEVVASKHVKKLAGGRRDFLIRLFGLALNVMSILIELDYSQYTSPFFGYKGYLQRGLLLFFVAIITSPDPTHHGLVKGYADDDYYVADAENSISGSAVGFQAIASFVLGACGLVYFAFGVLLIDRFTSDSFVTTDDPVVTTAIPTPDEIEALDRPGNSRPVSMQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC71</accession>
    <name>A0AAD2GC71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS23816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="142"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="483"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="602"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1969646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="624" mass="67079" checksum="591B61B9025F53A5" modified="2024-05-29" version="1">MNDAAFILGDSVEQDVPPALRGLEPSKARRMMEISKELQPILHGKQDKKSAALPPIAPTFTQDNSDQNGPTKVKIGNKMISSDKPARKWTWTSFASSSRPDGALFNHWVRAEVEYTDYPYAKFDVHMNQVVYTDDEYAKYLKSDEWTKSETDYLMELAGKYELRWAVIHDHWFDYYNSADVDDTFITRSVDDLQKRYYSVAATLSQARISQIAAEESQRLSAIVPDQSAPDAKERTEAVLLQTAAAKSLAAAHPKNQPLINSIGTGTSNKMFDADYERERRLHLDRMWNRSKEEEVEEIRLRKELKQIEAKLRKIKKMGGHITGAARSAGVVAPSRMSSAASSRNASRSQSPVPGAAVADSPALLGQSFASTAPMPMPQNPYLQSGRLIPPATGGATGINKTLLTKMDQTLKELKVSAKPVPTRRVCDLYDTVRKHILTLITLKKQLMQKEGSLQAKRVRLAKLRGGDSQTPDEEALLGIVAQPSPAPAAAATSKGSKSKGGKSKAPASKSKAGAQSKAGGQKGAQTKGKPDEAGKAETQGGAKKGKSGGKRKRKVDNKAQTAVASAVAVPGAALAAAAAAAAAMKVTPTAAAAKTAKAVAAKTVPDVASEAKPAAAKKRARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDP3</accession>
    <name>A0AAD2GDP3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDP3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1969934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="108" mass="12319" checksum="68F7C0947DE7C9D1" modified="2024-05-29" version="1">MSNVCQQQRQQQQHQEFNEAYADILKACQSFYELPRSPCASALQLSPRLEDGLLEMSDSNNSANPQDPDMDAIQCDGCCTIHHHTPRAMSDYEQRTEAQIIQSSCRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDW5</accession>
    <name>A0AAD2GDW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Selenoprotein H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002447">
        <property type="protein sequence ID" value="CAJ1969995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15785" checksum="CEB7BF562DCF5851" modified="2024-05-29" version="1">MARVTRSSTRPKAPAKVEEEPVVAAESSPKKKAAPKKKAAPKAKAAKPAKKAPKKKAAKKEEEEVAAPVEDEEEEVAEEEPAGASEDKSAVGDKAVVEINKEKPGKGNFVVRVSGVEAPIVELVGLKRPFPPLKALDMDDVCAKVVAAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGI3</accession>
    <name>A0AAD2JGI3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS11321</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGI3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007866">
        <property type="entry name" value="TRIC_channel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05197">
        <property type="entry name" value="TRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1947813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="429" mass="48908" checksum="8DF86E8E4664421A" modified="2024-05-29" version="1">MPFGKLFKGRSSSASHFSDNYRTAIQEDLPSKWIFHGVELNNDITGAPVEELVLLALIIFFLLFKNKILGRERGNNYAVWATVLAISYPLMNVIWIPLLSTILYTRTSYPYMIVISHCIVASCAYRNELEQRSLRYQFRKKPRDDTNGESMQKVKPRVHPISSFTWTFLCYGFGGSIVSDWLLGLPITALGHPRILACHTICYMLVWYCPYDWCYQEYMDPTSFWRYFLNLWEAVDGITTPPGRIGRASRELKNQVTAPLMGGMLAGVGGSWIRYGERSMIQGLKPEDPISGPSISAMEVGFWNTFLHSVLWWYFAVFSCNMGWYENIGNELREHHCASYSGTDNLRFGLVMTAIIWTTLKHTGLVSSSMKHPFVWFGQDAIAPTWNKLTQLLSLGPQYDAAMTTLDDHEDPSEQESGGNDVFKALKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGM1</accession>
    <name>A0AAD2JGM1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042078701" evidence="1">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="140" mass="14820" checksum="974879853AF0AD87" modified="2024-05-29" version="1">MKLFIATLIALVIVGTNGASHTAGNNTDGNNTASANGSTCALDRDCESGFCSIDFTCKEKKEIGESCAQDDDCFTAFCSVDFTCKEKLAINETCVENDDCQSGVCAQLDGFKCVESSEALAWNLTCTMLGAIASFLFIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH91</accession>
    <name>A0AAD2JH91_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS12544</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001763">
        <property type="protein sequence ID" value="CAJ1950349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH91"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041779868" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="22"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1950349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="671" mass="76589" checksum="C20F0C97AB7927D8" modified="2024-05-29" version="1">MMRCYGVWLSAFFALVSQTDAFYLPGVNPQSFSEGEPVKLKVNKMTSRKTLLPIDYYGLPFCQPAGGPKMDNENLGEFLGGDRIESSPYLLKMNTDMYCQQLCISNLGNDEQRGIAPNKVIKAIRREYHNNWIVDNLSAASIVEDDETITTRYWQGFPVGFISEDNRKAYVHNHVNIELMYHPVENEANKFRVVRFTVEPFSIKHDFDSIKEVGDAANQDGDSPETEQWATINNPIQSCNKDVPLTQREHTNYDMVIADGREPQEASGRVLFTYDVKWIENKDLKWASRWDIYLSMDNAIPPRVHWLSIANSLVIVCVLSAMIITILLKSLRQDLARYNRVLTDEEKADELEERGWKLVHADVFRPPAFSPLLLSVACGTGAQLLCMTFWTIVFSAFGFLSPAKRGALLMAELSFFVLMGAVAGYVAARMYKTFKGKAWQYATLCTALGFPGLCFVMFFTLDLMAWGYESTDAVPFTTIVVLLMMWFCISTPLVFLGAYYGYKQDAIEIPVKTSSIPRQIPDQPWFMGAPFTLMIGGILPFGACFVELYFIMASVWMNYYYYVFGFLLLVFLILIITCAEITLLFNYFQLCNEDYHWWWRSFGTSGSTAIYVFLYSFVYFQNLEANSLPTYILYFGYMGLASIGLFLMTGFIGVASSFWFNKVIFESVKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH94</accession>
    <name>A0AAD2JH94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="77"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="348" mass="37584" checksum="82A28FB4A74A5AD3" modified="2024-05-29" version="1">MRLISKSKSDQKSSLSFYLAHSTSSIVCNMEAIIGDKLQDLASAASFRQDAGQSSATEPSTEVFAGTVKVRPDDSSILFGRGKAYNSHPGNLKMRSVLDKYRDEYRQSLKGEKCKLVRKVHDELVGQGMKFMKQAEGGHGWVEVDLTAAVQKVGLSLRNPKILRHKPTANKSVKAPVPDKSSSSAFANVGKGQPSGITSKEASVATAMQKQTGNSLGLEELGDLLNHRSALAEMETVAGGFQQLQNLGDLMQPDNAGFAEHAIALLQNHFAELELERLRSTLSACMGPLAHSSQQSFQSANQVYTSAERDLLASVANSSSQFNYSFPDEDPMFWIRLAAASLLNTGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHH5</accession>
    <name>A0AAD2JHH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHH5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042085154" evidence="1">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="223" mass="24383" checksum="F914EB50C2244EDF" modified="2024-05-29" version="1">MMKPVSLVLILSLSSMTRSNGFVPPLLALKEQTCCQAHNKIEEEAPSSSSSSQSRRHWISSQFQSLLLVGGVVSEVSKEPASAAVMAVDQQKIGSLGIPESKERFVQARKDVQYLLDHYESISKEGGDAVRRYLGTVGVAGAMYGISKVVKTLREEAEDIVEYTEAMDEFNAYLYQAEGAAYQSIFAEHSSAKATPESCLATAKQDVVMMAKYMDKLQAQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHR3</accession>
    <name>A0AAD2JHR3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001775">
        <property type="protein sequence ID" value="CAJ1951002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHR3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="360" mass="40127" checksum="733CCFDAF58A0549" modified="2024-05-29" version="1">MPEKHGKSSEVYKELLHDFMNFKQTGWKPFGPNIGGVEHMKSKTMYEKKMASRHAFRSLAKKVAADAVGLLPSSFIEDEGAQEDSDDDDDDDDEGENKAARSSSANAASTSRKTSSSKPIDLTCQAAKEDVDGRILGFEVGQMRQHYLLQYPTGNKLGVVCCLDGDVEDRTSNQFKLSNDGKTVTRMRRVPKECSSANILLKGADEDDREGVMAGFGSSDIDVIVLESAIKKRMENCKRDKDGQIWEHRDVIDLPFACMPTMVSKEGKPMKTFKVRKNTNGFRWASFWLVGKHAAKAAGASESRRFGGTRVFSPTADDESLYSYQTVRSNDVPMKHVQVEKKTTKKKTATTKHTMRSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHY7</accession>
    <name>A0AAD2JHY7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001800">
        <property type="protein sequence ID" value="CAJ1952126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1952126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="95" mass="10628" checksum="297778A8AEDD9E99" modified="2024-05-29" version="1">MCSDDLYALTTSSSIITILFFWNCNGVGRFGSFVHFRCESDKPLSFVDLSTRLFIDFVFFIDELAIGKFVAPTGPYLLLTIGKPNTSMSNPFEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ04</accession>
    <name>A0AAD2JJ04_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ04"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="721" mass="82018" checksum="CABE6D4CC2C2206F" modified="2024-05-29" version="1">MSNFVVHRTQVERVLNPHRPEGNDGSQLHLLSMPRLSSHDHNWNNISQRLRNIPSSPVQLLRDLPNTIIHVVEGVEDTITDLATLTDNVSREVVQLPHRASHQWKELIWVLGLLVLVPLLVVGMVFFLPLNSVNLGVSSNKSFLYGISTFYEGLYLIAWVETFNFALPEASTPSATKASIPISTRFTVWAMGLAFCKLVDATFAKDIALLPHSVFPIPFSILVSGMTSILLVIIPLLYCLAPKIRKGHGFQSLIKLIAVYWIALLLVTLWAVGVNRLRHRRVLQTVVGALYAPLRFVCKVFIASPVTSNQNPQKWIQLNLVVDMLFTRVQVATFPFIDSYVTLLVLFAAEILTLGWRYYNGVDRLALWWSTMRIAKKTRAWNELGLTWWQLTKGCFQAPILEVAELHLKLQQEQPEMKERILRTLTGDTGDSHSVHSDGMESVSLEPDTPRKRYKPMSLLDIETACGLVDEQILMSETSTTTVLMQNPPNSTHDHECSSVVAPALNDVDNPNHDNRKNRSILASTIFQQDEGPDLIDAANAFRMEQIHRNLSVHTASTTPSCRLLHEQYREQRILFHVVDSTGAIVLSTITRISQQLCITMVRHLPSSKHLNQSFQIDDERWTRAQIYGWLYVGLMIFLLSRLGFFFFRRIQGFEERKLSLARVMSYLFKDHFWFFFCWLLSSGVLVCASMVNHFGADFSFSFEWISCPDAMAWPTCVVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ62</accession>
    <name>A0AAD2JJ62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="1">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="18196" checksum="B6F7CB108F9BD572" modified="2024-05-29" version="1">MGDVDLGLLDDDDYIKSVLRTKRLGIAECFIYRLPSGSKSPYRADGWPLTKPLQCVSLRVERRDNSLLLIFTYTHDGKANGASKLFALSAINLVDSKDKELPMEHYVESVLDSTRFFVIRVTDDKAGREALVGLGFRDRQEANDFRSALSKYESEIASERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJB5</accession>
    <name>A0AAD2JJB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJB5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38517" checksum="9E929D2F3A4B65D7" modified="2024-05-29" version="1">MPSLGQSRPNIRSRSNSPNRDVVSAPIKVFFTLILLAAYCLSDFVGDMIERSLQEDDMPMTTKSFRENGAGMSTGAEDFERIIKQKNGNWSETEIVTYMTAHPQRNYFSHLFAYGGFRRGIEIGVQDGRFSEVFMQQNSKLMNDQWTWVLVEPNPTKYLNRRLGLAGKQSKWAGQGYLENCTVNLQKTISTNPALLDQYPDGYFDFVYLDASHTYDAVRAELPLWWKKVRSGGIISGHDYCNYGEPGQSCNGCKLIPQCQDYTGWGVESAVFKTGRSSNQNGVVRAVQDWMVQESGNPFLTVRHTIEDFTQESLTKDGFDFGMVLRRDRNPSWYIYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJI1</accession>
    <name>A0AAD2JJI1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001908">
        <property type="protein sequence ID" value="CAJ1956228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="281" mass="31439" checksum="C81B8CB2CE63D1A9" modified="2024-05-29" version="1">MRFVNRKGVYVLEQLGATVKPGARETSSMYRRQFSNLNNQPHFKLSSNKQNGYAGLEMTSKMATVRKNKEGFTPRQVKAVMEARRHFKAAIQSPSIAYCDALFRNILLTTGFVPLQWQNLMNFAIEKKPGDFRLSKMRTIQLMNSEAQANNKKAGRAAMQFAKAHSLIPDGQCGSRKSHQAIDLALSKRLVWDLLIFQRREAGWISNDAKSCFDHVVHWVAIVTMLRFGLTWRVLSSMFNMLSSATHHVCTGFGDSKRSFCPPSAVPLQGCGQGNGAGPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK38</accession>
    <name>A0AAD2JK38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="562"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="869"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="903"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="932"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1958596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="944" mass="104332" checksum="070B540E7D19549C" modified="2024-05-29" version="1">MEVGEPPVAESQDYALRFEDLTVDDDLPLTDRIARYCRSGIALQRLVHVKMLAETSEVIGTRMTIAALIPLLPQLVVDQESVIRQHLASQILPLALVSMVTNVGHGQPYKVSQMLEDRSIRKVYDSQGYEIVTTAVVGYLNKLIQDPDVDVRRSASDSLAGLAMQVRKDDIAKAILPIPLQLAMSPKSSKRQLSPEQESHMEELRITAANLLAELGGAAEKDGVPVNVVRESILPAVLSLCDDPGFRARRAAAQALPRVLAGTTMADAKSTVLPAFEVLSKDEVYRVRKSTGECLVDMSRSMMIIASKERDPAAVNALRRNSLIPIAESLLVDTNKFVRHGMMQFLGPFLASFYPFVDSALYTILPGSSESDGSNHSGIVAQFFPHASSMVSRLNSSAAATTSAPTPTLASINTETETPLIKELQKALPQFIGASRSSAVSLKAVVSHRQKYRPDPEDIKAIVGRLLHHFTGLAKVITGDENTDAEMRVYCAYSYPAVVLLLGPENWEGQLKDCFKTLLNPNYGLGEKAETAIPPLPVKRCLASSLHTVAHILGPRISAFDIMPIFRDFFLRDTDESVRLNMIRNFPTLLSLLDPATRQQYLILWCEMIQGDEVLGALKRSATNPLVLNWRQRNCVSRSIADILVMMDAVFVHTYLWPILKLVLTDSISLVRDDAIWAIPILLKALCSENVIMDKTGGDAMRSKERWSANACQEVIHWLWESILKMTPSKSTGKLTSNGRNSNFSQRQLYCQICTALALAIQFGDGLKDPDDPVLELENKFSTHLSAQDITEYGPYRRLSDSERSHLVGLLANDMLPVAINFKDDGVTNVRRSLLKTLHLMPHDFTHFPAFQEATSVLEEEVQTWESFDGMQQNNPPAPPVPAQKARAVVPAQHQEYQNGVSSDEKTRVDVHDDGKGGKKKSSKGRRKEQTSETGFVTHNLASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK50</accession>
    <name>A0AAD2JK50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UDP-glucose:glycoprotein glucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS16535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042265015" description="UDP-glucose:glycoprotein glucosyltransferase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="7">
        <location>
            <begin position="73"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="8">
        <location>
            <begin position="313"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="9">
        <location>
            <begin position="468"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="10">
        <location>
            <begin position="1319"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1957078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1600" mass="178979" checksum="3E2C60235305002B" modified="2024-05-29" version="1">MRLSQYLLILSLAVSPTIASGWSWSSSSTETETEQSDFVSPIINREIQVSVQAPWASSPSNVYCEAWSFLHEWEFLNALAVSPPADNFDDFESATKRAVDIASNALPDSNHKLLHYSLTMRAKSPACEMQRSLATQYNLNGDFCVINGEAVVQDVADLPAAIPRLPDVELASLKLPGEDPHPTSKPSSGLVVLYTNFGSPNFGSWYEQLVAKDLPFVVRYSGHGILESPSTTLQGYGVRLDIRNVEYKVFDDRQDQAEEEALVNATEVSSDVPDFLGGVNISALASEVSSDLQAELWKIHEAQTQHSQLIPPTWQRRKLSLQAASVIAGAAGDNALVTLEQVSQNLPSLASTLVHVEVPEKISDAAEKIGEELRELIRESGGGFWINGKPLNVVRSSFNIFEMIQLLQDEAKQLQRFEGKFSQHFEKQEALEQVQIAWSKGEQFFQGQQVGGVESVSDHRRIDVASGEKDAVIYLNNVERDPQYADWPTSMQQMMMMMQYGMSPSVRRNLITILAVDDPMEKQEETAWGKALFYQLAQSNFPARMGKLIVDAHDVKVCEYWVKTNKPGPDEPCPTIKSWLDTGDIPDTLSKMEHAKAEARDVYRCYLYMAKKYKGRSDIFIKYDQMFGPTLRGNVSRGYTSLYILLNVHAGILQDLGLVGEKDPIMKVAKEVLEVTKDDGYGKVVRFAVEKGLRPGMSFLNGRPMPDVGEKDARENVSKLVMEEQEEIFGMIYNGEITDTQPRNFYRSMLVGKNKKNVFPRVHPLLTGSADNLIDLDIDNASSSFYLKPESDLAGSKADAVFSVDAFFDLRKSVGLSLAHQFLTMMKDFQSSIDETSVSVAYRIIPSKSTFTDASLCKLVASAKSLGSDKMMDAFNSLVQGKSASDVVASLDVDESAGCLELLPEDLPADNFLVANGRYFEIDGDSVAQIDVELLMRTSMAETKAVSSMLRPYVSSDYPHSAVASTTAFLMASKSQDRSNPSDAIDDLEQRSDLTKNPLRFTWDGDSGSAALKTRVLAIVDPVTETAQRVSSLLKTVRDDLGLSTTLVLAPQMLLESGSKVPISSYYRFVTDSSAYQGGENSPLAHFSNLPTNHILTVRMDVAEPWDIQQRKAIQDTDNLRCDLKSGCSDHAALGTTPDGVPMYEQRHLTEVEFNLNHLLFFGQCYQVNNGVQPPNGLQLTLSRQYEEQNEQLQEVQLEADGSISAQGVDVGTREVGIYSDTLVMKNVGYWQLPANPGVWDMKIDENSRGSEIFDIVAGTISPHGAVKLTDSRLNNHTERLVMGDFVTSSETLLVKRRKGYESTTLFHDKTDEDSEDVINVFSLATGHLYERLLKIMMLSVTKRTSSKVKFWLFENFLSPTFKASAISMAEKIGCEVEFVTYKWPQWLRGQSEKQRIIWGYKILFLDVLFPLGVKKIIYVDADQVVRGDLKELWDMDLEGAPYGYTPMCSSRESTLGFQFWRSGFWEQHLRGKPYHISALYVVDLERFRRDLVGDQLRSVYQQLSADPNSLANLDQDLPNYAQHSVPIFSLPQEWLWCESWCSDETKPDAKTIDLCNNPLHKEPKLSMAKRVISGELFEESWEELDAEVGKYDKEFFETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKI2</accession>
    <name>A0AAD2JKI2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="421"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="509" mass="57867" checksum="67601D25FCA37463" modified="2024-05-29" version="1">MASSSSPYQHTTGIINNNNNNDGWFQQCLGTSSSPIPAPSQDNNDTLSDIMKPTEDFLASEMSKLSVQERSKAMDELHCVGEELKETPEMIQQSLKEFDKLLQKKKAKIYDLAASQNRSYVEDPNFRLKFLRANIHDVGESVNQMLGLLSRKEIYFGRDAIARDITLDDLTAEETEILFSGLYYHIQDGTDRNGRMVVYLLNHILGQLSSAETAIRVNYFMFFNILSPMPSVQKKGIVLCYYDFSTPDKPAKLPKLDALLKFMDFVPMIPVRRSALHLCLKPHRGGLVSSNKFLENVLRRFGRSTRSRARLHYGSDMELQYTLKSYGLNMENCPVDATGNLRQDILDVWAHKYLHQRNRNSVSSPPAKDGEIMTDEQEDSTDSMVQALTRPKLPIAPQKNDHGTDPPANTAVSLIKPTPDDVLFGKGSVLQMHPGNVRFRQFIKDHQEEYNNTPRYKRVTTFQDLTGVLLGKGIRFLKKTESGGWVESDFAEVEKKVKQLFRSQKKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL99</accession>
    <name>A0AAD2JL99_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="343" mass="38151" checksum="7A2EB1E0676EB2A5" modified="2024-05-29" version="1">MSYSRSLEEEETSFDWDSLRSSRYYPHESESSSMTTSVTIRVTPEHYYLVSWSILWGGFLLAILAASIQVHIENEWLHTRRQDIEQGNPSGDEQAISSADVSRSRFRRLLLLALVTRAVMMPIHIWRDPLWVQFIADTLPQMAFASAWTLLVSFFVQLVGVAQGTATSASPGIVAIQLTACVVYVSLVVTFFFNVIAAVLMYALFCCMYSALFGTTMYFCPKLLTLLRPSLSQHSGLAIRLAFCSVLCLFVFGFSTFGFARKVVAPPHQILWWWNYGFLELIPSVLFLIMMRPNSNRSPDSGAAAPDANPPAAIGRRGRGADTVPFINKSPAATGGYGSVQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLA8</accession>
    <name>A0AAD2JLA8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS18966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1960953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1960953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="470" mass="51809" checksum="4D567F2A13271812" modified="2024-05-29" version="1">MTTEKRISVFLQANMSSGSLPLATYHRAESLGAGTYGSVVTVYNDDGENFALKMFDQDGDDQDNVGTSIGALRELTILRLFRGENAHPNIVEMYDVQTGFEEEEGAGTGGAMAMAMPIFPRGSLEDSIASFPNKKAKIAIAYGLLSAVAHLHENGIIHRDIKSDNILLHDAEDGSLQAVLIDFSLAKLIDPKAIITDATGESSSQIETEMTHTASIGTPTYRAPEVIAEKGYGLPSDLWSVGVCLLELLCGKCLEADKDKNAIKLIEDGLNTLPDAPFPNLIRRLLQKEPEKRIAAREALDAPVFKKFDFEPHERTFVRLNINEAMPLENDPNAAAAALQAGSKENRPVENKSKGNKKQSKMDPSLAKRFKLIRQICDSMEWKSPMTAQAALMYSIAMSELDDVDDTANSQALLDCIVLAHKFFELELTDLNELSEASKRFESWDIDEYADNEGTIFMMLDFCLLPRYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLW4</accession>
    <name>A0AAD2JLW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLW4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="369"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="458" mass="52621" checksum="B2A36FE40D85D57A" modified="2024-05-29" version="1">MLDDSLWDKFLWDDCFLTKEDVPDTDTTPDEDESKRAQVFSGPVPHNASDPESADSLIASQMAKLSVADREKVYNDVHGIPDDCVEETSELIHNSLWGLQHEIDILPDKKAYNIAERLNPKYTHDREFRLAFLRCEKFDCHKAALRFVRHFQMKLDLFGEDKLVRDITQDDLDVDEMEILHLSNGRFLNVHDKAGRRINIIVMVKKTYKTDSCLRKAFYITMTAYRDIEIQRRGLVNVSIQFGNEVKGTSADNPDLVWKLPKQNQAIPLWVSAIHLCYTKEAWEGHNAMVKTALDKQSKVRCRVHCCGTILECLEELRGYGIDPSCIPVNNKGEITDRIKDHKRIEQQRRQERLKYPAPSTIAVPFCEDVLLGKGTPFQIHRGNKKLQQFVADRFKKYERAQKGAKKAVAHEIVEAVRSNGGLFLKQDGNRWVPVTDDVALLKVGALFRYLRLKNGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN23</accession>
    <name>A0AAD2JN23_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002262">
        <property type="protein sequence ID" value="CAJ1966193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN23"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="155" mass="17526" checksum="52F599DEDABA3788" modified="2024-05-29" version="1">MKAYDPSLGGSMSQLWSSMQSLFSLGDLEDADDDKGSWALREYFLRLATQCPTVVFDLATAQRVITTDKKSPCFWEFLLVFDPTLIVQRAELLTWMWLASSEFFAHPWTGPAIIPPIVEEFERLERESKIAKAQSKSKKRPASTPENPKGAKAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNK3</accession>
    <name>A0AAD2JNK3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PROP1-like PPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042142705" description="PROP1-like PPR domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="3">
        <location>
            <begin position="283"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1967027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="558" mass="62004" checksum="C7386B7BD36FD4CF" modified="2024-05-29" version="1">MKYLQPCMLAFLAASAQGFTNPSSSVISASSSLNSNVYGLPARRATSVAMETSSADLQQFNVVLDKLAEQCSDTKKPVISKAAECEEIWKTQIIENGEVLPDTISFNTVLKAWNRCCSTLSECQRLKLTVPTDFKCSVNVFTPLDAARHATSLLLEQKDPPVDLASYNIIIDTWAKSRAPEAPEAAERVLKLMLDNDNVEADTFSYNGVLDAWANSGREDGIDKIVQIYHHMEGLQKQGKDIQPTIRTVNAILNAYAKVVSSYSRVSHAQNRRTDKIEDYSEAAFDLFDKTKKKADEIGDSAWLPDVMTYTILMDICSKCGTYKATQKAEELLKELKEKFAKTKQNNLKPNFRTYTALLTAWSRTRSDESPTRVEELLDEMKSNPAAQPNARTYTSAIQCWGKSQDSQKAKRVLKLLLDMKNSQKSDARPTIMTYNAAIDACAKCVGSREEQTEALKISFAILKSAEADDAVEVNSMTYSMVLHAVTKLLPAGPECSQVASALFEKAKKNGFVDQSVMRNVRSCVGPQKMETICEGYATSSGHYDFDSFPNSWKRNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPG2</accession>
    <name>A0AAD2JPG2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPG2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1969698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="211" mass="24068" checksum="6D1C964687AF59C2" modified="2024-05-29" version="1">MSEEKPLYVTDPEKWLRDLTESNDFVGIVIFRGHWCKYDKYYLKKLGKYNNETIKSEHLKLIAWTSEGADGAKQADEEWGLTTKFGFDEVIGDDTNALANYLVEDCILEDLKTMTPEEAHVTDHVTKGTYPNGMVQPGMIWYAHHGSLVLQWESEVSPPHFGGPNRPLPQDTWKEVMKRKHALDLGKDVMPVHGKELRQCATNMEVNCAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVG1</accession>
    <name>A0AAD2PVG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10808" checksum="342D2A098290429A" modified="2024-05-29" version="1">MATTTTAVTPGKYLDLDQTPIQGQTGWALLDLNGNVLVLSGSLPEANLTVLYQMLLETTSLVNDKDFRKLTVSFQSQQYLVSRDENHIYVVETTSIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBV0</accession>
    <name>A0AAD2CBV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Uroporphyrinogen decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS259</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:31240"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19866"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1898771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000008">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042020550" description="Uroporphyrinogen decarboxylase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="13">
        <location>
            <begin position="91"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1898771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="456" mass="50616" checksum="5B0EF1BDB2B803E8" modified="2024-05-29" version="1">MKFFVSQVFILSLAVDAFMPAASKRRPQNHFAVKISAEEDLELTRQVIARQFGDEGSTTVTPPTESSGSDNKLFSLTFDRKSSYSSPPRPENDLMIRAAFGESVEKTPLWLFRQAGRHLPEYQAYKEETGRNFVELLAFPDSVAECTLQPLRRYEVDAAILFSDILVIAEALGIEVTMPGGVGIQVPEPLTSPDQVATRIPNIDAISEDFVKDKLGHVMESVRLIRKKMEEEKIAIPLIGFSAAPWTLLFYMVGGSSKKNNEIGMQWLNDHPEESTTLLQILTKVVVEYMSAQVENGAHMLQVFEAMGMMIDEEKFEKFALPCLEEISKELKSRFPDVPLMVFSRGASFANAKLAELEYDVITIDGDVARDSARRVIGDNVSLQGNYDPRELIEAEDGSKTPETVRQTAREMLEALGPQKLIANLGEGLGGKESTTLVKAFVDAIHEESAAMIKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCQ0</accession>
    <name>A0AAD2CCQ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS1730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000091">
        <property type="protein sequence ID" value="CAJ1929646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1929646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="609" mass="67393" checksum="FD34AC1E0FFDBE92" modified="2024-05-29" version="1">MLDLQTNYCREVEYYPKTVSKAQDMLKIHMEVSKNPGVNLYQGNDQPNKGKGKGKGKGKGKGKGKGKPKDGKKAACYVCGNEDHMSPKCPDRLLPKTQWKNQDQYVDYGKKLNLNQIGATVPATVPAIVPGASASTSGASSVTGSINTPLRLAGTTGNQMMQVPSGMQLMQIPTQGGGTVTGKDENGNDVYLIPCPAGTTNVELQANWHYASENKDLPDLATEADRGLQFIQSRRKERDPFGLYNHVIMDSGCTNTTICNVYQDEDGIANVLAMREMIAAGYRITMDTDADNAFIVHCDGNQKMQFVNRKGVYVLEQLGANNGYAGLEMTSKMANADNDVDDMPELTVRFQGDDDYESDDNLGDEGNKEEEPIVADLDHHQENVDGGTHDIGSLVTDLEDLQEPPEEEIVFEPEEPQVAKVTQSGQMYAQAAMSGLNLSQVPKKPREWPSSRSGSSANKNKNRVATRRQHRERELKPLKNKLKYGIRTKEGSCSTKDSKAILEAKHNLCFQQIGNEMKAAYEEHDAILIARCMMQIKAKFDTDEGLNFIQQYYINQGLKKFGDDGKDAVDKELRQMLRRDCFTPEFLKDMAASERKKPQSANITRGNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCU7</accession>
    <name>A0AAD2CCU7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1903793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCU7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1903793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="905" mass="101022" checksum="BB8057FB4DC09315" modified="2024-05-29" version="1">MPRKPRKSDSSTPGINPRENLLDHRNFLARSLTRNDNEIYALVKLNRSLRQAKEAILQSCGELVLLDIGLGKLKLINDELHQAQQATPAPATTTTTAAAAPPPEATPSSDDDDDDDDNGDKEKQQTTETTTNTAAAAAAVEETSQAAVVHHLSPAQKDLCVDFLLKMKLRRKLCNRLSRRLNRIAHALDGEDVAPPPPPRYGDLSLNIDPQALKDKEVHWKLLKEAQERVELAKKNKNENGNSTDTDIKTTTSETEPPQETTSSLEAPLVKAEEPEEKAEKEMEDEKTKKAEPAIIPSAPEAAPTGDKVVTPTTKQEPEEKSEDKKIGEETNAADMNEPEKKEENGEPEKKEESAEEDPESVISKNLFASPVKKEDNGGVPMTQTERDEELLKSYDDAYEKVWDATTNSFKYTILDEKREPDYATIQDGGVGALSRHMTDEEREAENQRWQSAILARIPKQPTFEDLGLTARVFCLEERLKRCREEADQEEGEEEPDSNKKAKAEGDNDEDAMDVDKAQDEKESSKKEDGEEGGATESSTPKKEIKTPEKKNMGAAEKKKEPPKKVEKEFKPTKPMSLAAVPSFHNQDTNRLRMIQADMIGQTIISTAKERLAGLVHSYNDALIKSVQCYNAKQQIAQKVALNLEQGRREVAKANSEYALKVSLGKQKWLVEKKEHDNKRLATMPSRFGQLAIGTNAIQTYMRINAGDQIKLMVGQALGDLVDLTIMQAEGKLTTNTKYPDFVPPTAPALPQQFRQQQQTLKNEHDRLAAAFNQLEEQRRVKWRKYMGARAEIEVKHGVSSRRTAATYSSTPCPQLNRATQQSIPNLQFPVMARAGYTPINKPPSSDPKYSAAKVKQRIANDGSVAPVTEPKKTKDGLYMRPSGRTRKGMQWDALRGLWVPENYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCX0</accession>
    <name>A0AAD2CCX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1905508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1905508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="351" mass="38330" checksum="55FBF29082CBF10A" modified="2024-05-29" version="1">MSEEGKEPSEAKGQGILGKQFQRMRRRLTVTGASSNIDGVVGKGQEVPEPKKSKKKKHQAAVRCAVTEYSGVSKKGHAPYNPRKKNQDALIMADDPGTNSLILAVLDGHGEHGDYVSAWFRDQLITEMFNHPAWVNNLKEAVADAIGKVERDLLRNFRIDTEFSGTTLSMAIVRGNELTGVNIGDSRVIMGKQEGGGSMTPVEITFDHKPDSPKEKERILACGGRVFAVEYDDGIDGPPRVWLGHMDVPGLAMARSLGDVVAHSAGVISEPEFTEYKLNPETDKFLVIATDGLWEFVSNQETIEIVEGQIGPAQAVDTLVTEAGTRWMKEEQVIDDTTVIVANLFGWRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDD4</accession>
    <name>A0AAD2CDD4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDD4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042062723" evidence="1">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1923524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="155" mass="16806" checksum="BBE0AC8B8F286138" modified="2024-05-29" version="1">MSPLHHILLSTLVTIYMCLSAVSAYSVGPNPNPKTSTQGPEISRRSIFFAPIVFATASMGTANNVHALDMDGFMNSELQKDSKPDQGMSADEALCRFGSPSPETGKACVRAGMSPERKGKPVDAFGKIDRGEYVRCKSFWVEGASGKLEKQWNCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE36</accession>
    <name>A0AAD2CE36_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000025">
        <property type="protein sequence ID" value="CAJ1927766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024741">
        <property type="entry name" value="Condensin2_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199:SF4">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12422">
        <property type="entry name" value="Condensin2nSMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="512"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1927766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1267" mass="140959" checksum="34159D00C5D4A81F" modified="2024-05-29" version="1">MPISDVDAPKHQVAIKSIIRAVESNRSEGSSENSFSCCGPLVRLLVRSGQSKDCDDIVPGLTYKQQRDLIISSIQTMSKKQSNRFFGGLKKHVEGILVNEAYVPSSVYNETSGGDKDSAIIPDDESTKCLCFLKCAAICVGKFLEGRLQQEKERGKPTGLELSIVPQVYEVASNLHKILFSLHVCGPDGISTQDSVLEMCEKWWLSNGENKESLIAQCLPLIVLKALDDTEFQSSHVKRLFKLREAFLVIDFKNHSSDSLRSLLLRIASNPLLLKLPEGKKFLSCLLRDPDLITDLHISFRAQIPMSKKTALQSYGEIYLWSWRDASQDAEELRETIEHTALQDLMYASIHVSSEATLKSVMTVLDVFFFDKKNTEIASLLYRLYNPILWRSLSATNPLVRKNAVRILEKIFPLHDPTTSDTRNAMDKAIKALDSALQDKDITVRIVAADATAKIAVLFWDVLPASAIRSLLNHIIIGHASDASSVAVRVAALEAIISLLDIPQSHAVLRPLLPSLGNLVHDKSERVRSSALKMLLKVKEIRGIRYFHVVPVSHLTARLSEETRLHHDPRNAISRQLTALMLNSYFPQGPNVSGADQLQRTLTFFHTDPDAAVAFYANLVDLLDMKPLVKFIAMLLTCLKSAVEVEQAKVSESAKSKKKRRRSPIQEQEGGATEKLVPSNIAFMEALTETLCIMVESIMPRTSADCDDDCNNLLLQQFSDVGFVNILVYFGQLGSELHDYRCEEASGCLRTSSSLLRCMSHLPKETVDGIADFVFASMTSWNQEYQPPHLVLSHLAPLCVWGMTVEVTETLARSIQVPFKDENNIFSPLSISLDETATAHRRTSIQRQSSHSTIIPEQDPYTALEVINTILQSSDPSSTFLKDQILTCEKSCASIKLALERGIALAEKVFQADTNFGNGYRESHFEYILCMCETYGKFVLHKVATIENSDEYRSQMKTLLEWTTEKALVAFLTARPEGNELRQLDLSRISNVSDSMVLSPPRQKVDLRRTPTRLGRPSFASGSDVPPFLLTSFTASLLQSACILFAEELALGSANSNDIADAAIIWCKVFGEANKESNEGAEYIIEGMVPSFFRLAIQLCKSSSNFLLLKELLTSCQEKTLRRVKDHVKKAISSLLHGRFGEQSNLTDGIIETVISAAANTPSDTDETILETDTFWTTQNGCVGLALEAIFTSKTAAMALVQRLTQDLCLVADETTTVDMFKLRCLQELMSRSSLAAEKTKRDLTVDQFKEGSKMRGYVQKLFETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CID0</accession>
    <name>A0AAD2CID0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000313">
        <property type="protein sequence ID" value="CAJ1933900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CID0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="175" mass="19500" checksum="6F3F5AC1898C9469" modified="2024-05-29" version="1">MAVTNLTPVKSLSDLSQASYDTNATESTSSSSDYKRVSFGAIHVREHERIIGDHPETKIGVPLSLGWGYHDKASTPIEQYESERVLKGKLRMSSITRKNILHNVYGIPEDEIRAAEKEVRIISERNEKMQQKSEKKAKKVSTMKKVGKQFKKILNADAFIKGLAAASPGTSMMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIX2</accession>
    <name>A0AAD2CIX2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIX2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="96" mass="11077" checksum="C992853D20B13D80" modified="2024-05-29" version="1">MAKYQEIQSRHGRSLLFVSLIRFLKHEVGVPFFKPIQDKQLLNEQGQWYVEMTEKEATDKVGHAFRDLARTTKIQQQTTITAEQRIGTTLSRITGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIY4</accession>
    <name>A0AAD2CIY4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Haloacid dehalogenase-like hydrolase domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS3884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIY4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006355">
        <property type="entry name" value="LHPP/HDHD2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01458">
        <property type="entry name" value="HAD-SF-IIA-hyp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1934544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="276" mass="30226" checksum="4C6E21E6BFC6F149" modified="2024-05-29" version="1">MIRGVLIDLSGTLHVGGKVIPGAVESLKRLRDSGKRVRFLTNTSTKSTSRLWQEVLDMGLCETTSQGQMEDMLLTSVLATKQYLMKHQKRPLCLMEDVSDFEGSVNLSPPHDCVVVGLAPTKLNYENLNQAFRVLLKNDSKSKGPTNNNKLIAIHRGNFLRDADAELSLGPGGFVTALEAATSSSSDKTVVMGKPSTEFYQSAMWPDFRPDEICMIGDDILGDIQGAQTSGIGTTILVRTGKYRADDETKIETPPTRVCNSIIQAVDFILESEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJR2</accession>
    <name>A0AAD2CJR2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000550">
        <property type="protein sequence ID" value="CAJ1936130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="231" mass="26828" checksum="0A0A73C35C02B3B6" modified="2024-05-29" version="1">MELLKHIIRFMKKSADGEYDFLNFWEANQKFFAMKQGTTENLMHFKEQFLRQAEVLQDLYGNAWFQNFAVKTKSYAAITSTNTAAKDKFKDDIFEAVLATEFLCKCDQTRTAPLMLDLQTNYYREVDYYPKTVSKAQDILKIHMDVIKNPGVNLYQGKDQPNIGKGKPKDEKKKTACYEYGSEDHMSPKCSDRLLQEIQWKHPKHYVEYGKKLNLNQIGATVPATVPGTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKN7</accession>
    <name>A0AAD2CKN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial import inner membrane translocase subunit Tim23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000650">
        <property type="protein sequence ID" value="CAJ1937461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKN7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1937461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="19944" checksum="36E076C6DCB8D98D" modified="2024-05-29" version="1">MSKEFEGDAGAPLPDFTGARNISLDTVAPALGVQSQHAQPDYLDYDQKGRGMVTTMFANAGVSYLMGITAGGIYGLQKGIVSTPSSKLKVQINSVLNHCGRYGSKAGNSFGVVAVLYSLYEGVGDKMELERYSGVESLSPPLAASLTGFTIYAPSGIRVAALGGAIGLGAVGATYAGYTMAGKPFGSYGFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMP8</accession>
    <name>A0AAD2CMP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000824">
        <property type="protein sequence ID" value="CAJ1939658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMP8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045050">
        <property type="entry name" value="Synaptotagmin_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10774:SF190">
        <property type="entry name" value="C2 CALCIUM_LIPID-BINDING ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10774">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="7">
        <location>
            <begin position="210"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1939658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="452" mass="50549" checksum="C1AB9187FEA728FB" modified="2024-05-29" version="1">MRKDPPVAFVNGFGCRTLSRRSHHNQYSEPETLLFHHSSRHGSSPQWSRGLYSPSLHSRHHQHNANIFRGNQPSPVLHSVNPLLAAIDLTSTAVVYRGFGFFSLLVSFLVGGLFFSSILAGLTAITAIGKRNALEVLSIVRLVVSNVWGLFVASLQEFRKALRLDGKWQWKSAWMVLKSKLLETRQVAQDGVNAVKSQAKFYAAAVGVPGLIPIQYLLDRLMPYTIASAMEEALKDALNNLKGNPQIRAIQLASFESGTKAPQLTASRAYELENAIAFDLDMVWKSNLAFTLNITPKLLWIKIPVSIQNLVFKGCVRVQLTPLTKKPPGFGAILVSFPEVPVIDMDIQVAGGQITKVPWLRKEIENEIAKAVKDEFLWPKRVVIPSAPNSLSRKQLLELQQEDKDPFRLAELAQESEQPILKEYMESCKPDQKSLLSNLKIMVRPEKEEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMZ5</accession>
    <name>A0AAD2CMZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS6730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000846">
        <property type="protein sequence ID" value="CAJ1939771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF63">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1939771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30611" checksum="04C3889E7E6D0C85" modified="2024-05-29" version="1">MYAVGPHRKPDIGERIKVRKWKLWGSWMRFFALEIVVDAETYYSRELLEKQAIVGISPHGIFPFGLAFATLSELTGVAFGKIRPVVATATKLLPFVRDVLKWVGAVDASRPQVDSALSSGARIGLAPGGIAEMFEGYPKPNAHPNEEYIIIRRGIFRLAMKNNVPMIPVYCFGSTKLLKRVQFPRIIEKISLLLRTSLVLFYGKYGLPIPFRKRLLYVMGNPIHPPEASASADQQVETFVASYCNELIRCFDRHKQSYGWEEKILRILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNI6</accession>
    <name>A0AAD2CNI6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000965">
        <property type="protein sequence ID" value="CAJ1940831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="532" mass="60477" checksum="61F59176DEBF3272" modified="2024-05-29" version="1" fragment="single">GLFLFVWIQIVRPTCVRKTCVKSRHHDQSPIARVKTLYLNSFFWNVKTHILSYPNTVHSWVWVDDFLIHGPTQGLQFFLDTAVDCGFLFHPKKLVPPQQVVKCCGFLFDTTAVPCLQILEAKKERALAICDYLIQSLKHKSLGIAVAVGFLESLTEATPRRLGHTHLKEFHTIVHPPGLGNGAAPYYTTTFLNLEVLDKLQWWRQFLTRSEGRFVRGWEAATLVPTFGDGSGTGTGGTMQLPSCDFEMWRGKWKPSIYIFPSVWKELATLKETLLWIKESPHAHQVIGTTVFYFTDTSGVYWIATTGSSRTRSLHKLISEIRLLELDLQCVLQVVHVAGQVLITQGTDGLSRGVLMSALQDIMDSDRLTQAVFDPVPFDMTLVWTHLPQSAHLTQYRSWNQPWTASLCLHQTTVWCPPPELARKRLTFLLNSWVKCPFTTSALLFVPRVVEASWRHMSRYVHELDTIYPNKTNLRFLPLLPIPIVVLYIAPHTLSLNPNSRLDKTPIAARSWHVAQATLMHGLPERVQPQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP58</accession>
    <name>A0AAD2CP58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="62"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1940032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48649" checksum="A0056BCA9E2AD311" modified="2024-05-29" version="1">MAPKNRIWTLNDLNGSSQSFTPPEESKGPQHPSANKSSSVTNAYEQEEPVNDPLAAQYCQPINSKDGVPLFHIPNLLSDKVCEDTLKRIHQEFLPIIQRRKFNVKSISELCCCGDGLDYRPKRGRKLRKMSNNVLGYNMTRWHGRSKTHTIHLRLRNPNNHTRLFPWEDVAGTMAHELSHCVHGPHNAAFYKLMEEILEEHATLLVNRMGFNPDYRQPTGGGAATPSDAFQTTKGQTLGGKKLGKSRLVDGKSSNGGGHRLGGSKVSNRKAMQEAIVRAAESRKRQMDLTRRMMEKAKQPCVIEIYDSDDDEEGADEPNQGAKMPVRSNRRRDQEQQQESTTKRPKVECIDLTSPDTKPKAAETKNIKPIKPIAVDNCIDLTNDVEDSSMKVTVPNATIVTTCTTSDGWVCAHCTLQNRPLSLVCDACLQERNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPH6</accession>
    <name>A0AAD2CPH6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001002">
        <property type="protein sequence ID" value="CAJ1941403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="392"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1941403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="741" mass="85180" checksum="F898DBE9B19059DB" modified="2024-05-29" version="1">MSNASQRIIPLEEGWNDEIKAKAIDKLEALLNGGLDSGQASMFGPREYVQIYTTCYDMCTQRSPYNWSRELYDRHGQTIERYLTSNVLPALREKTGQGGTILLRELNHRWTNHQIMNKWLKKFFTYLDRYYVKHHSLPTLSQSGLRRFQTHVYDEMKQDTTTAILGLINEEREGKIIDKSLIKSIVELYESMGMGTLDAYNADLEEALLSATREYYAKKRDFWINDSTPEYLVKAEEALNEERNRVADYLNSSSESKILKVVEEEILEKVEMVLLEKETSGCRALLQNDKSEDLQRMFRLFSRLENGLNPMASIVQSFISTMGDDITNRRQARLDGGEKDKNDDPRFVKALIALHEKYLGVVKKDFSGHSLFQKALKDAFVEVVNKNVGQYTNAELMSTFCDRILKSGGEKLSESEVEETLDRIVQIFSYLTDKDMFAEIYRNQLAKRLLNQRSTSNDAEKLMIAKLKMQCGTQFTSKMEGMLADLAVGSEQRTEFEQRMRSVDTKLDFSVQVLTTGFWPSYKSPQVSLTPEMSKCMGVFKEWHDTKHQKRKLSWMFSQGNASVRGTFGKKSYDLQVSTLQAIALNALNDGITLTFEEFSRKLNLDHAIMKPLMHSLSCGKYKVVRKTPPGNKINASDKFAANAKFTCNMRKIRIPMASLDSSFNTKRVEEDRSIAIEAAIVRIMKARKTLQHQQLLSEVLAQLAFFNPNPRVIKKRIEALIDREYLERSADNPHVYNYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPL1</accession>
    <name>A0AAD2CPL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transmembrane protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS7752</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPL1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012430">
        <property type="entry name" value="TMEM43_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13416">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13416:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07787">
        <property type="entry name" value="TMEM43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1942048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="51645" checksum="00F67F36CBB74324" modified="2024-05-29" version="1">MSEEVVGDVTGYREVMEYSYFDRMKNALTAVCIGLLLLFGSWGVLFWNEGRSVRRGTDLDEGRSIVYRLGMTSIDDTINTRRDNELVYISGIVDGGNNAIYDEVFGLNVSNATKAIKYERSVQMYQWEERSQTKTEKTSDGGTRTVTTYTYYKKWSSRLIRSSRFKEYVTPSNPTSFLVPKYEETSNDISLGPFRVSTEISEQVDWDVTWKDAPIDTSASNFPDFPGKTATFSQGELRLQRNRGLNSIGDNKVKFSVVLPDYISVVAKQGSNGVLEPYITKGDRELLLFARGIKTSDELFDKAEQDNVLLTWGLRFSGFLTMVIGISLILNPIAIAFDVLPFCGDALEDVTGNYIIPCIALLVSIPMSLMIISIAWIFYQPLFAIGAVVMGFLLSALYITYFEPKLSPKRREPSSPAQEVEPQDKTVGDEAEPEAIGSVEEPEPITAVPPSKVIVLKVGYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPS8</accession>
    <name>A0AAD2CPS8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPS8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="94"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="338" mass="37028" checksum="CFC8092DE5C0C2F0" modified="2024-05-29" version="1">MQHAFPHYFCGGLQQYNSRQRGYFAGISSNFKVMKPSFKSEKQTSANKPSSSKPDSIDDDPSGNSEVRQQNDTSDTSNYHPNAAAVIVPDDNCIVFGRGKGANNRPANKRMRVIIDSYKDQYVAAERGEKCRVVRKLHDELVERGMRFLKQVEGGTTWVEVDTNAAILKVGHALRSAKQDKQQQKSVRPRQPSVSNNSQSVQEAQVAPHCEPVQVSATALIEANVLAQTSLTNTPPLPVGPSLMLDSVLGGLGASRFAAAGTSYPSLSLENSRLMEMEMNRLLSVSQLSMGVAAAPYVDLSGLSTSQLLLLVERQRSLRQMMLNDTSIWPRHFPGAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ64</accession>
    <name>A0AAD2CQ64_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1936652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="503" mass="54823" checksum="EA08E07C7F7933F6" modified="2024-05-29" version="1">MKPSDIYTSLPALAFTATAILVVLHERSKKKNGSTKKESPPSAKPMTREEVLELRQKHFMKSVSISYANSGGLMIMGGTGSRLIDDEGTPYLDTRNNVAHVGHGNSEVVKAIQTQVSVLNTNTRYLHPNAVELAKKLADKLPDPLEVVVFVNSGSEANDLALRLARAHTGSKNTIVVERAYHGHTLSILEVSPYKYEYSKEFKMVPNGQYGTPGKHIYKVPCPDIYRGNYRNPDTAGEVYSAYVKDACKHYQKTGETVGAFFIEGGMSVAGVILPPTNYLRRSVEAVRAAGGVYIADEVQTGFGRLGSSYWAFQHGAEEVVPDIVTVGKPFGNGMPLAAVITTREIADSFQAMGVEYFNTFGGNPVCCAAGLAVLDVVDKKGLQKHALEVGAYLKSLFLELKEETELVGDVRGSGLFIGIELVRDSKTLEPATAETSFICTQLKDKYKILTSIDGADDNVIVVKPPMVFSKIDAAFFVNCFKRAMKELEAMGDEVLQMKKTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ88</accession>
    <name>A0AAD2CQ88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="42"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="133" mass="14386" checksum="6F6A78D9389C58FE" modified="2024-05-29" version="1">MWGASNIARASVMAFMTKSTPTQVLLPARAVSTTTALSATQFLLKYDYIPDVLEKRGPFREGHLDLAKQLIEEGTCLAGGPTGPVGLEVPTGAIFTFTTEEAAKKFVEGDPYVSNGIVTQHSIEEWNVVVQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR52</accession>
    <name>A0AAD2CR52_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR52"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="237" mass="26811" checksum="7FA9AC887B540D09" modified="2024-05-29" version="1">MTDTDQNELVAAPLPQPNDPASTPYQYLFFDKIESEFFPSQLTPQTLSWVLLSKGKRKSQLSMRARVLEEPDSENRVLVQYPKGSTYRVRRKNLMPVLEHQSNLILVASETNDYRRSAIVHTLESDSFMEIGCDFGILVDSVHCESKIGIDKSEESIGIAKERYPSRDFLLADVFEDFDASAHKPTVVAIDINGNRLLPAVIDCIQLVMDAWSPRLIVVKSRELYAKMKADEESVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRM5</accession>
    <name>A0AAD2CRM5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001158">
        <property type="protein sequence ID" value="CAJ1943908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="600" mass="68679" checksum="269EA9C3770B2E0E" modified="2024-05-29" version="1">MCCHCDISTNDIINPDAFKKVNLYSPEDFDTNQHPPGDEEYWKSVSHHPIVNALDEMCHGSNSHKTHIDCPAELLHMLQKGGQMWAVESFEYQFRNGTKITLDDKSFASKKKGIKKGLENLNFIGHQMGAFLSRQSDRNKPRTKFKNSLFSSAKKCGHEHAGVILSILLTLMTDRGRQICLEERTMEEDFLDNFVYLFEIVLVMEQWLKSPSFPADEVLDGTRLSKALGVYVENIGAICQRKGMGARLIKNHLMLHLPHYIMRWGPPSGWDGSNLERSHKRQAKRPAQLTQRRQDCFIAQLSARYTEMRLMQYATQFFGLCKSLWATNTGRGRQSTKPMACTGSRFTVGLDTTNSRPGVKWTKDPGRQVHIQTVIDTAFDHIVSNLPLNNSKSARTVDGFTEYKKEIRGESVIFRAHPSFRSKSRQQRDVWYDWALFDLEDQGYGSCFIPGQVLMFLHVPHLQREVTVNGMRVRPNKPHAIVRLFKEKPRSDFREVKTHSETGEENEYSLLVEFGDTQDELSIIPCDYIAEPTIVVQNIPMLQPQMPLNPKQRRAREKMDGIIKPLGEGYFVVSPRSTWSSCFSHLIQSYPSTLGFNSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTY5</accession>
    <name>A0AAD2CTY5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTY5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019656">
        <property type="entry name" value="Uncharacterised_Ycf34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10718">
        <property type="entry name" value="Ycf34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042176312" evidence="2">
        <location>
            <begin position="32"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="212" mass="24169" checksum="3DCFD084CA0561A4" modified="2024-05-29" version="1">MMRFHDAYNNFILVVALLGLILQLQLDGVKAFAPRSEQSFLRPTLSTTTIRTIALQQQQQQQQQPRNPSSSSALNCICINCKYVTSCKAYHFVEEKHQQPHMTEDPTFEPRNGSPTIHVNVRIIRSSDDVKSEYERMYKEHEHETKKAEAEAGGGGDDKNAPLHGSAKYDLSPVTTYEYDVVKCEDYVEDMGCWVRNMPQEIKEANPDFVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXQ5</accession>
    <name>A0AAD2CXQ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001613">
        <property type="protein sequence ID" value="CAJ1946146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXQ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="29366" checksum="995D2BC130ED3659" modified="2024-05-29" version="1">MSNAARRMEQESKIANVHEACQKILRKEEDTFKNQRFQFSHYLVRLGYSTEFVENYVERGLMPRIIKEAYVNFLALLNKICHKDMGSDEAWEDSEAYVILQVHLENLLDIRTNSNSKKMLLLQNYIYLRDARKKDFGSNTITEKNIGRVNKMNQKLQRELESLRAAKGRGGREPTKDKDKDKEGDSTLKKCSQCKSRTLHTALKLEHNKTVCPLAGHAGSWAKVAAERVATAVLANKERPVGDIIKEVADNWPKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYR4</accession>
    <name>A0AAD2CYR4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS10095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYR4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF33">
        <property type="entry name" value="ALPHA-GALACTOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="7">
        <location>
            <begin position="370"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1945953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="500" mass="55986" checksum="12AEF5A08414EDC8" modified="2024-05-29" version="1">MGLSTWSVFRAEINHTLIVELADSMVDLQLLEKGYTYFLMDAGWTAEKPNCPSCLSHRNETGHLYVDPTKFPNLKDTVDYVHQKGLLFGIWYGFEMCDDATFAKSTTNDDYAHHYATLDANFFASIGADALKHDICDAVVPNTTQGRQHNFEKFQAFGDALNATGRPMLYDVSLIVSKARETPAYDYNYVYSPEPYGQELVRSISNMWWSVPVNKYNCWKCCVHPQEFIVDDEEACNDPTKLPAWRGLLPILDIQDMKTPGWMGHWDWAGKAKGWNHLDQLSSCMGKSWYGPGLTPSEQVAQISLWAIMASPLIIPPDIRKIQIGEFCHFLIANPKMISVHQDLLGIPGRPVKSFYKDDDGTSKEIIIGQLWVRPLTGGAVAVVFFNRQEQPLRMEATWQELGLLSSSSNSTTTATTATTATTTTVVQGMNVWTDEIRQNISSPMMMVSVPPHAVSFWILTPKNTKEITKNDSSRIIRGSSQSRMKNIEGGTGTAGIVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZX6</accession>
    <name>A0AAD2CZX6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001269">
        <property type="protein sequence ID" value="CAJ1944900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1944900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="220" mass="24202" checksum="F3B970A400309F89" modified="2024-05-29" version="1">MKDNIVNPPEKDPNLIMTVADQGQGGLEAKTRSNSTTQLSIALTKDNPAITTPKRSSKRNPSETAEDGAMKGRSLFPSAVPQVQDVTVNTRPNPTTPLSIMLTKDNPPDPTTSKSQRKHPPPSKTAEDGAVQGRSLVAYITKLKVSTFHRLYKKAWRQEMFALATAQRVITTDKKSPCFWEFLLVFDPTLTTRRAVDLDVANGIRILRSSCYHSSHCGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBF2</accession>
    <name>A0AAD2FBF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase B</fullName>
            <ecNumber evidence="6">4.2.1.3</ecNumber>
            <ecNumber evidence="7">4.2.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">(2R,3S)-2-methylisocitrate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">2-methyl-cis-aconitate hydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Iron-responsive protein-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CYCCA115_LOCUS964</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="6"/>
    <dbReference type="EC" id="4.2.1.99" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1922200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01581">
        <property type="entry name" value="AcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01576">
        <property type="entry name" value="AcnB_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000008">
        <property type="entry name" value="Aconitate hydratase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.310">
        <property type="entry name" value="Aconitate B, HEAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004406">
        <property type="entry name" value="Aconitase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015933">
        <property type="entry name" value="Aconitase_B_HEAT-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036288">
        <property type="entry name" value="Aconitase_B_HEAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015929">
        <property type="entry name" value="Aconitase_B_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00117">
        <property type="entry name" value="acnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006690">
        <property type="entry name" value="PRK09238.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF4">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06434">
        <property type="entry name" value="Aconitase_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11791">
        <property type="entry name" value="Aconitase_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74778">
        <property type="entry name" value="Aconitase B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase B HEAT-like" evidence="24">
        <location>
            <begin position="36"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase B swivel" evidence="23">
        <location>
            <begin position="205"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="22">
        <location>
            <begin position="513"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF06434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF11791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CAJ1922200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="916" mass="98607" checksum="797DE033D690397B" modified="2024-05-29" version="1">MMLASRVTQACSRHSTQLRRGLLSSSKRSMSAFLAEYDAHVAERAAMAGGIGIAPKPLDASQTSSVIEELKADSGNERLLELLVHRIPPGVDEAAYVKATWLSALAMGKESHPSISRVYAVELLGTMQGGYNVGTLVSLLKDPETEIAESAAKQLSKTLLVFDAFYDVEAAAKEGCAPAQSVMESWANADWYLAKPEVPETMTATVFKVTGETNTDDLSPAQDAWSRPDIPLHGLAMLKNTREGIVPEVDGEIGPLKQMEELKAKGYPLAYVGDVVGTGSSRKSATNSVLWHMGDDIPYVPNMRAGGLCLGGKIAPIFFNTMEDSGSLPIELEVGDMNMGDVITVHPHEGKVTREDGSVLTEFELKTNVILDEVRAGGRIPLIIGRGLTSKARLSLGQGEAVDDIFSMPAPPSDIKPKGFTLAQKMVGKACGMQEGEGVVPGQYCEPKMTTVGSQDTTGPMTRDELKALACLGFSADLVMQSFCHTAAYPKPVDVVTHHTLPDFIMTRGGVSLRPGDGIIHSWLNRMLLPDTVGTGGDSHTRFPIGISFPAGSGLVAFGAATGIMPLDMPESVLVRFSGEMQRGITLRDLVQAIPYQALQEGLLTTEKKGKKNIFSGKILEIEGLPTLKCEQAFELSDASAERSAAGCTIKLDKEPIIEYLNSNVVMLKWMIAEGYGDVRTLERRIARMQEWLANPVLMEADPEAEYAAVIDIDLNELKEPVLALPNDPDASALLSDYSGTKVDEVFIGSCMTNIGHFRAAGKLLTNLAKPLPTRLWIAPPTKMDEAQLIEEGYYSTFGVAGARTEMPGCSLCMGNQARVAPGCTTVSTSTRNFPNRLGQGADVFLASAELAAIASIEGELPTVEKYLEYMDKVNATAADTYRYLNFDELPEFVKSADTVEISAEMMDAAKRLSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBR3</accession>
    <name>A0AAD2FBR3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CYCCA115_LOCUS1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1887662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBR3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011565">
        <property type="entry name" value="PRK14989.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042260964" description="Rieske domain-containing protein" evidence="17">
        <location>
            <begin position="19"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="18">
        <location>
            <begin position="943"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAJ1887662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1089" mass="118567" checksum="7E00EBDE768DCD39" modified="2024-05-29" version="1">MKFVTLIALSFVSTKVDAFQTASKPWASSNVGKSALYVEKKKVVVIGNGMVGQRFMEKLLDHAGDDVEVSTFCEEPLAAYNRVKLTSYFETRNPSDLSMTSEFDNQGSTSWYDENGVKIFMKDKAVSIDTDKKTVTGASGREINYDACVLATGSFPFVPPIPGKQRPGVFVYRTIEDLEAMLAYAKENNVKSAAVIGGGLLGLEAAKAVKDMGITSHIIEFADILMCRQLDEGGHGALVGKIEEMGLHVHCGARTESFVGTDGSTDNDSMAPVAALKFSNGWDDLPVEMVVVSAGIKPRDEIARDSESIEIGERGGVVVDDYLRTSQDGVYAVGEIALHKNFIYGLIAPGYIMADVCSKAVAHDLGIKVSDQAPSFTGADMSTKLKLLGCDVASFGVNQPKPDDLDVQELVWNDPFGGIYRKLIFNKAGTRLRGGILVGDASDYTQLHKLAVGDEDFPDDVTPAMLLPPASCKSAAADNREEVPSDPNAQICSCNDITRGNVVEIIRELGVEGASLAEVKKCSKAGTGCGGCEPLVKSILKTELEAMGGAMSNNICEHFDYSRQELVALMRAEKDPSNVDSFDKVLEKFGHGNGCEACKPTVGSILASLQNKMVLGDERYQMQDTNDRALANMQRGGTYSVVPRVPGGELTPEQLIVLGEVAKKYNLYCKITGGQRVDLFGAAKHELPSIWEELGKVGFESGHAYGKALRTVKSCVGSTWCRYGVQDSVSFAVRVENRYKGIRSPHKMKSAVSGCVRECAEAQGKDFGMIATENGYNLYVGGNGATNPVHALLLAADIDEDTVLKYLDRYIMYYILTADKLERTAVWQSKLPSGKNGGGPIEHLKEVIIEDSLGLCEELDSRMQHLVDTYHDEWAEVVNDPKLRKQFDQFANTDENIDKDSMIEFIDMRGQARPADWPKDGQPQTNWVAPSGDVFINSEKYWVEVGLVSDFLPNVGTPILYGDSQLAVFNNKQRGEWYCTQNMCPHKQAFVLSQGIIGDTNDVPKVACPLHKKAFSLENGQQINDDGNLSIFTFPVKIEGDKVLVELPAEPEVDAILGTHGLRVQKTDCIDIAGDAMKVAPKPNKFSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FES7</accession>
    <name>A0AAD2FES7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000469">
        <property type="protein sequence ID" value="CAJ1935391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FES7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="615" mass="68562" checksum="324C90C16A93E667" modified="2024-05-29" version="1">MPKKKTNYNKRGFAKRLSSRIFSRRDKTSKPEDQWRPRKTKFAAMPADDDDDFSAPTIINNFSFSVESETGGYKKDIDTKKKQAIRKLNKKTDFAGINIQPSSRDKNTNSARKKKARADTQSFQLSSDMSMDHSFDSRQSAATRQTTMSDPTNFFSSQPAALTMNNLNHFSNDIENQNPRSKFHQFTIDEDKESTVILPVGFTDDDETTHRTFDEDISSSRCSGSRRRNSSYERAFTPFQEETKSVFVDSFASAKENTHSGLSTAPSLRASDENVSTYSRSRNPSVASLCYSPSPKHESYSFASPNKRTCEAKGSKKQQRFIRDGRAPLSPLNGTRASNSGAKPFFQKRNDPFSGLGSWSDFVQDTSSNSHSGFKSTDNISDIYEEKSSQIFEPRNGGESKWSKGLYDFSDESKPVSSFDSTDSVGTFRPRLEEEVPMGIQSFEGVSKGSSVPSSVISAASSQGRVIYNRRVTPSSFDDDDISHSNRSVGRSSHGGGGGSVAKPMGLPSNAIMASMLFQRHHTIDTRAVETKLKAKREESSKLDASRSDVPRAIQAQDDMYSCVSSFSEDTTSVGPWKKPTRDLLDHFSNSRRTEYDAGRFRRDQLAKAPTLFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFW0</accession>
    <name>A0AAD2FFW0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SREBP regulating gene protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000447">
        <property type="protein sequence ID" value="CAJ1935313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFW0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042186070" description="SREBP regulating gene protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17500" checksum="587366D8F38CBCAD" modified="2024-05-29" version="1">MVSRFLTILLVSVALQYAAGLSPVSLFGTSKAQRVDIDFASSNEDSTDTSNACESRRIFLSAAAMQICLLGATSPAKAAADGATVYKSGKAPIVPGQKPKDKSDVKGTRKDPDFLRSIADCRNQCQSSNGPDGFAKAKEDCLSECQDICCTTYEQCTFNIVPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFW2</accession>
    <name>A0AAD2FFW2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="117" mass="13651" checksum="CC5022CA634B1F41" modified="2024-05-29" version="1">MKADYEEHDAILIARCMMQIKAKFDTDEGLNFIQQYYINQGLKKFGDDGKDAMDTELRKMLLRDCFTRKFVKDMTASEQKKAQSAMMLLVETQLEKTISAEYRQIFQTTVARGLYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG16</accession>
    <name>A0AAD2FG16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protochlorophyllide reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000491">
        <property type="protein sequence ID" value="CAJ1935610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16728" checksum="71AD1098A875C382" modified="2024-05-29" version="1">MSILVQTKLYHSLWKDFLMSTVAKVFVITGTASGTGNVAARIVAKLGGVAVLLNGKSERSNKSLAAMKEDNPEGKLCPSSATCKASSLSRKPSLRSRASTLAFIASHNAGIMATPDKATVNGYNTQMQTDHLSHFLLVEELMPVLGAGAAANVAARIAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHL9</accession>
    <name>A0AAD2FHL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHL9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000154">
        <property type="entry name" value="Vesicle-fusing ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042188832" description="Vesicle-fusing ATPase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="460"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1939195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="749" mass="80168" checksum="60E73947D7C18513" modified="2024-05-29" version="1">MAGYSLIQCILATFVLFASTSPNHLGATGFTASPTYTVSPRSHLGPLSSVNGSPVKEKEQVEVNGALPPTSVIEESTTSSSSSSSSSSSPIQTETIKADDDEYDAATFDIVSARAARCLYDSEVKRDSRVSEEPTPSTATNWINDASAYALQKALDKLKIKLPEERTSIDRDESSSWMRWMKSAPTPLIVDLSASTREIANQTISDASIDLIDLTREDFLSRLGCRLILFPSGSSLSTPLLEPPASMIYGKLLYGGITRCRLLSSSNNSKRPPRKAGERTDIKMSPSDNIPAWIQYGGTERMYEAVDIGPAAILEFIILPKSVITRGLTLADIAAPGSAGNDMVVQNLAWKPQQIFDILPDSNSTSGAQSAIDSMDFVTGYTPISQSGKDRNDAFESDFKTSVGGLGNQIDAIVRRVLDGRVIRPADEDSNNQDSSDDTATALTTAAMEAEELSVLGLTPVRGLLLYGPPGTGKTLLARQIAKALRARAPKIVSAPELLDRWVGGSEKLVRGLFAEAEAELAACNGDATRSALHVVVIDEIDAVFRRRSGGEDSGEATRASVVNQILAKMDGVNVVNNVLIIGLTNRRELLDSALLRPGRLEVQIEVPLPDREGRREILQIHFGALRNRGRLSMPLCAAIDGVANRKSTMEGSAVKSESSDSEEIGGRKRDKFMDAIKSVWYEASSAVRPSYDLAADSATGGFSGADIAGLVRCAGSLALSRARRDGNGVEGLLITLEDVKLALGEVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHM9</accession>
    <name>A0AAD2FHM9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHM9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="135" mass="15098" checksum="6E4F7AEF6B9F5DF4" modified="2024-05-29" version="1">MSTTNNMNMTQISMHVSATNMKRTDGMKRKSFLSKIPAPTVAASPMRRILSHTNKKSRCNLIDEALGIVNSPVRSSNGIVSRRRGSMVQRRGSLLCERRASELLFDNGDRLSELMRNCQTDSAEFSSDDESDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHR0</accession>
    <name>A0AAD2FHR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">7-dehydrocholesterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CYCCA115_LOCUS2978</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="16"/>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHR0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF38">
        <property type="entry name" value="7-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="14" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAJ1932721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="499" mass="56110" checksum="C4006784EF295444" modified="2024-05-29" version="1">MAAPSSSKSATTTNNNNNSKKNKDYDNDDDDDDKYNKSNKSEYDKGTNYVAGGIEADPYLFALLIASPFLSLLLAYLTSPEFAAFHPEPPLLVSKLVPLCVANVGGCVTGIYSAGASVVPTVESVTFVLSFMGVALVLERLLPGKIETGPETLTGHVPKYVDNAVAHCFTFSALFVVGSNFGLNLYDFGIIYDLFPGSVAFLNLFGLIFCIFLTFKGRYFPSTQDCGSSGIFLKDFLWGTELYPRVGGLDLKRFINCRVSMTFWQLAGLSYCYRSYTLHGEQLDYGLFFAALSQYLYLVKFFYWEMGYMRSIDIIVDRAGFEIQWGCLVWVPSVYTLHSRYLVQYPSGLSFPVAACLFVTSLLGVVLNYLADRERDVFRATNGKCKVWGKDPTYIQAEYTVLDRKTGQKTQKTSLLLASGFWGVARHFQYFFELTAAWSWCLLSNPIRNGILPLFYACFLTYLLVDRANRDSDKCKAKYGKYYDEYCQLVPYKILPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ75</accession>
    <name>A0AAD2FJ75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CYCCA115_LOCUS8975</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAJ1944613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="322" mass="36160" checksum="B5A1EF12F98FBADB" modified="2024-05-29" version="1">MLKEAVEGQLASQKALRKVVDHFPQNSLVSAFGYGSGVFSQSLNDKHEGMLDIILVVDDANQFHEENMDRNPSHYPSWLKLSGAGMANRIQRNYPLKDARVFFQVVDSPVPMKYGVVHKDDLISDLILWDTLYLAGRLHKPTLPILPNTPDEILEAQSRNLQAAVAAALLLFPEEQEEKPIDWSSLFRQIARLSYSGDFRTTIGAEHPEKISKLVDAPGQLRRFQTLYEPVLQPMEEMGLLSNSTSNLEWNSSDQSARKALVKKLPPNVQSYKNADDLAKMLAAIVAPAARHQSFKGVFTLGFRKSITYATAKLQKGLFRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJG9</accession>
    <name>A0AAD2FJG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="304" mass="33960" checksum="B6DD1CE772CF3303" modified="2024-05-29" version="1">MSSAQPTNNDNSNEGVVSKSATGSSQKETVRLVIISDTHGHHKKLTSILPKGDILIHLGDFCNKGSASDALEFANWITKMAAIPSNQKQISSQHALYEEIIVLEGNHDRTRKLSPAEIKAKPPIDLTKMFKRVNSDTDGKVQFLQDQMVQSKRFPLKFYGASWNSCAGDNFPTQFDFMGQEPPDVMLAHLNPYISSKITYPQLESLELVHAWRGAEGLSRTVLQNKIPLCMSGHLHWGRGVIHVPHNRNKQQQNNNGSSSVFINAASMKSHRDAGILYEPVVVDYDLEQRKPIRIDLSYTTVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJW8</accession>
    <name>A0AAD2FJW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS5153</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1936361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="168" mass="18488" checksum="6D8736C503BB2976" modified="2024-05-29" version="1">MGACVATRPKWRWRSPFSWHPLLMTWGLIGCAGISAVTKKMGGYKNTKNHGLIAMMGAIFACGGLYAIYHNKNLYERPHFTSYHGKIGLLLVISSVTVGLIGAIFLHPDFGIDKTNQKIRRIHKMCARIMLASAWALAFQGVTKISSDPLVLACYGVPLLLLAPFTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL54</accession>
    <name>A0AAD2FL54_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001635">
        <property type="protein sequence ID" value="CAJ1946169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL54"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="25628" checksum="B2B414656FA62B5A" modified="2024-05-29" version="1">MDVSEKDDNTTTAVSPESILYARARNRLLDAVAKRLVETVEPKTDPLVEQVRDQLPKEAEDVRKLPFYNSTLQSLQYQRDQYFMGTKYAADKQAAQQEQRQQQLQRRSESYDDDGENSLPFRRNKPPPNPLKAHYDPTSLASQQTIPLGASFLPSPLVHNALLPIVVGLPNGALREPILNATVNSIPMAQPALNDVVKNTMIQFLSNPHWKEVVQNQTNKTLIGSNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL72</accession>
    <name>A0AAD2FL72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000813">
        <property type="protein sequence ID" value="CAJ1939580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL72"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF281">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="2">
        <location>
            <begin position="74"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="453" mass="51830" checksum="016CDC4FFDFF90B2" modified="2024-05-29" version="1">MLPNLTSRFVNTSLLLPRTESSKPVIEKRDLLLSVPFYVYEDLAWNGATLSGKSVEEIADPSDSAKGKFKHGGDYWMWKASLNGHPMRTKNMSEAKLFFVPWLMNFWDYRVWKNRSLCVNGLCDIALLLDSLDKLVRSPAFQQYPDHHIIVRSFFSAASYKWNSEQIKRNKQFQRFLDAFKQMQVLVFEGTDRYPNKAAGRHSFTSYHVGSPCPIYSENDHGGKEKPFDVGMIGSLHKEKQAFKNRRKICKWLGQINDNNNNNKSNSTMIRISVCGEGSQCPALAESRFGFHAAGDTYSSQRLMDTILSGTVPIFTHLHQYELAGDWIDWSQLSYYLPVHDDTGAKNGKKKTGGPTHKVTIHSLRAAANCDIFEERLRPILKDEAGYQAKHEKILQHIPLFDYTTLYPFDTYMYLFQAELFPETRHPIGASWWSALRLPPPLFVDPPPPPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL81</accession>
    <name>A0AAD2FL81_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000824">
        <property type="protein sequence ID" value="CAJ1939652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="10466" checksum="89F801888C5D18F8" modified="2024-05-29" version="1">MIEARLKQRPYIGGRTSILQYFDQEPPFARHLLRKEESKQFYTLWVGTNEGAACRGRLSLSQVNNTTGNFLEPATLAALEGSSNCAKEKQGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLF0</accession>
    <name>A0AAD2FLF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS7112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000913">
        <property type="protein sequence ID" value="CAJ1940603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="302"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="891"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1249"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1265"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1279"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1940603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1291" mass="145132" checksum="69E438190DEA345D" modified="2024-05-29" version="1">MIFLAPTLPLVTQQAQACYSIMGIPGIDTAVLTGRIKPSTRFDLWRSRRMFYCTPQTVQKDLLSDDATFFASRVCCVVLDEAHKASGDYAYTKVIEQLELAGAQFRIVGLSATPGTSIKAIQKVVESLRAVKIEARYETDPSVAPYVHQKHSEIVIVPKNESQKDIERRLTRMLEPILQYLKAHGALKFGGGNATVTTFQIHKSCQEYLKSNRNASGSVRAYFQAAYKLIELRNDAYQSLGCVKLKIQRLKQTPQKGPLAKLIRSKDFDDLYRRVLNATNSAVESKTSSDLSVESFNPKLQKLAELLNEHFSRAKAAEKSSRAIVFSQFRDSVSEIVEQLKKYHPLVRARHFVGQQSSKRSVGDVDNRLGGMKQSEQQQVIKWFRENVYNVLVCTCIGEEGLDIGEVDLIVNFDTLRSPIRMIQRTGRTGRKRNGRVVCLISEGQEERTYKASKQAEQTLMIALKKCGSFKMEVHKPMLPREPTRQFADIKITGSFRFSQVGHSAPRRQTKVQNWNLGPAQEEERGQLLGKVISANSDWTAVRAVLLRGWCGSFRANIRGQSTQLLHKLKGIRPVKAKTMSRRSLTCGIESIFPIVPPHDQETKPARIAKPPVQMPLNGHEKTHASSHLPNAPALRKLGIPNRRDEIELTKSRSHSLNGVEKKVCERQEATALFLEENQFRRSNTESSRIYEKILVSNSNHDAVPQPTFRLPTPPPSSYEEDSDMPLEGGSFCFRLPTQDSSSSEEEGPTNCLPLCTSAKTHEPTYDEMDNVKYIPNFQVSETHYGTYNDQSELSNCRMEELRPGSLRHSETDDSDARLISLKRRTDEKTEKRKAENIPLMELKRQRKILIEGMNAGCGRKSIATSEMEDSMMSANTFGDAKMSPSAILGTNSGDMDSETGPGAKKVGNKRQSTQENDPASRWADPPIDNALTLFNKPLGVSKGHSLNSSQVRSHTADRSVGKRCQRAALELSLDCLTCGKSPRRHDRTPKSNARTNWYGELTDTPDYDVNIDPEDINCALCRSVASTDENPIFLCDGRCNRAFHKLCYSIESDIKSADPWLCKECSRAKEPLLTKRIIKRSAAGHISTKDNEVVGRQIHGCDRDNSKVEVKKKRLEVLQARRLGAARFVFDEADIEANDDMEGDDAENDMLEALEEEESIFNDGFINDSTQLSQHYSDDELGNVDPDASRDINFHHRNLDAQFDRKNQFITPVLNRRGCGLDLSAASSQEGLGNMHFIRSVLHHHQQGGDAQEIEDYFRDLQSREQTPGESSSVVHQSDNDSPDKWRNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLL8</accession>
    <name>A0AAD2FLL8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001068">
        <property type="protein sequence ID" value="CAJ1941720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLL8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="445"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="577" mass="63389" checksum="823227D44A3D6CD7" modified="2024-05-29" version="1">MADTDAQVAAMTAALTQVGIQFLAQLQAQQTAAATAAAAAAPPRTAVYNLHDSGQPVDLSSRSGAAAADKASAKLPIEITGDKAEIVIWIQALKFHCSETYMDVAGPTGILYFGGKNLLTDYHSILMTDVVSQATLRTDPRAKQNSGWLFKCIQSSLSPALLLQLFGLNGSMPALGQGDGPTLFKAIMDTTASASLVVSMQALTDLGVLDPADFDFDIKKINAKAIESNSLMLGSRGYTRRSLILKKAQLHRDKTKEVIDLPSTDLFARNQNQQEVPLLAVPQFITQWDDEHTIGELTDDFNSTEDPKTIISPPRENQESEHASIQEPEIRRTRSGRHSKPNPRIFNDQMATANSAYLETFSPALDHEELQGHELLQADHSEEPHPFASIFALAGSADPDTLTFDEAMKAHDRAEFIKAMYKELGDHIGRKHWKVVPIRSIPTYSGKRAIPMVWAMKRKKNPLGEIIKWKARLCAGGHRSIENVDYWDTYAPVVSWSTVRLMVIFALINNWHMESIDFVLAYPQAPIKTDIFMQPPRVPPKFAIVHPSQSLWISQTPIGPNPPAQALVSSKGEVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMP4</accession>
    <name>A0AAD2FMP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS10473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMP4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="62"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1946332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="505" mass="55652" checksum="5882A3B77F4EDB4F" modified="2024-05-29" version="1">MVFFPNQYAAYSNSDTLQRREAMRPQMSSIDSNTPVNMLQFLQPSQMASSASLLAFVKENNATLNFPQKLMLLLSYVDNERDRGNHITCISWVRDGHAFVIKDRQELVDSLLPLFFREGKFSSFTRKLYRWGFRQICIPKGGTKKDRDLMFGHEDFQRDNKSLMTEMRSVTAAGTRRAITALTSKKKAKKNKDKDATQKPSPVFIPAPAAPTQKVENTINLERFSPTEELKPQNLVQVHLERLLGGSYNPAKPATAKPQSPPIQTPSLVQNSTQSALGALLGETNKSEELKSQSLVQAHLERLLGGSNTSATKQANTMPRTSFQTPGLGQQNSTPSGFDAILKAKSHSLMPPPVQNKFLGLSDNTQLQAQVNYLKAMSQSSMAAQSPMQPSMSFDVGARLQALRQMGASKQAGAQQRITIPDALRQSQSNLSQTRNAASIGLPKSYLDLIQGSGTFVGSASVPNRVPMPNLIQPELSAPAPSSVVAHLQQRLSSNGHYAKQQQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMU1</accession>
    <name>A0AAD2FMU1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001713">
        <property type="protein sequence ID" value="CAJ1946547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMU1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="67" mass="7558" checksum="D3A739490102934A" modified="2024-05-29" version="1">MNTVVIWYSIRPLSIVGSSGRAIWTHVLVKDMSLRLHHGNIFPYYRCNLVAGYCCGDISVMVIRNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNC6</accession>
    <name>A0AAD2FNC6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042072572" evidence="2">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="152" mass="17341" checksum="A0A004BF70E0536E" modified="2024-05-29" version="1">MKLTLLSSSLALFLCQTQAFAPVSPSIRPRTSVLAVTEGETDTYFRAIKCAEGSSSTLEELEKLATDLENVLGSQYEEGIENCEREVRDRMDVAHMLRLRIELQLRMDYLKGENLFASDVQKSHDRDERRRFKELLEANRDKVVDGADLGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNQ8</accession>
    <name>A0AAD2FNQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS11220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001734">
        <property type="protein sequence ID" value="CAJ1947599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNQ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="30"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1947599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="326" mass="36240" checksum="11172ABB1660EB64" modified="2024-05-29" version="1">MNNTIRKPARKKYRKSIVSAGRCESASSRFEKIGRIGEGTYGIVYKALDRKSNNSLVALKRCIPHHESSDGFPLTTLREIHALNLAASHPNVVDLLTVAVSDSGVFLAMPLVGNDLAAILDDPTAQPFSEAEVKTLVRQLLSALDFCHGHSLIHRDVKPSNLLISYKTGLMLADFGLSRHIYKGQCCTVNVVSLWYRAPELLMQRNCSAYSFGIDMWAVGCVFAELLEGSPLIPGTDDNDQIEKMIRCMGRPPLNFLSDHIPKKKGIVSTGNLWDRFVDLSNEGLLLMARLLEYDYTVRLTASQAMQCEYFQVHPLPSTKISTLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPP1</accession>
    <name>A0AAD2FPP1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001754">
        <property type="protein sequence ID" value="CAJ1948754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="142" mass="15690" checksum="6C121BCFA4F356B9" modified="2024-05-29" version="1">MGSNDEKSQEMALKSTRTAPEHAQEGLEATTRSNSTTLLTVDLVKDNPCEHKFSMLYSIFVLFLSLEKIQQTNFLGLPFQIPTNRVGAPICPLTDDLRELHSILSLEKVPTKFLCIPGEILASCLYFPTNSGSADLSPDMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPP7</accession>
    <name>A0AAD2FPP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001756">
        <property type="protein sequence ID" value="CAJ1948790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPP7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="120" mass="13626" checksum="F65FA8313C1BAA37" modified="2024-05-29" version="1">MVDASKEFVAEIGAYVHGYGHDTKNNMAARTIEGVYMGPTDDIQEGHRIYDLNTKCEARRAKIKVLPMTDQVIKIIEEDARLEGVTELRTYSKRNGELSSMVICSKEWTQMNCGMKTTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQA9</accession>
    <name>A0AAD2FQA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoenolpyruvate carboxylase</fullName>
            <ecNumber evidence="3">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS11952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + phosphate = phosphoenolpyruvate + hydrogencarbonate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQA9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.90">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000584">
        <property type="entry name" value="PRK00009.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523:SF6">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041961968" description="phosphoenolpyruvate carboxylase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1949153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114681" checksum="FEB9DB808968A086" modified="2024-05-29" version="1">MAKLKTTLAAALTLLQCSSLVQAANSNNNNNKNLQANRIKGFRKHPFLNDHKNLASAVSDISGGASALLDGGTDIESIEVSIPLSQSPAVQANVEALLTDISMLTDILMDVIEHEDPNVRKLYDEFLSYGKARAENVSDGKPLETMIQRAKTLSNSECLGLCRAVATSLNLVNAAEVHHRIRSIKAYEKAIGENGLPGPLYHTEDSAKGTIQAILDENKDVSKDDIYKQLCTQKVELVLTAHPTEVNRRSVLRKYRKVGEDLAFLERPDLLPFERLQATYDLQGVISSLWGMDEIRRRKPTPQNEAAGGLAILESVLWDAVPSYLRKLDAQCMSSLGKHLPLNVVPIKFASWIGGDRDGNPNVTPRVTKEVVLQQRHKAAKLLSQDLKDLESQLAISARYSPAMIKLANSVSYTTHRQELYRRVLSHLNKRLIKTMRSCEDELEEYLQPEEMATLRTRASTSLIDEIDDLEPIYKKEDLLGPLTTIHESLVETGFELVADGLLVDLIRRLHIFGLTLVPLDIREESTKHTMALDAITRWLGIGSYAEWDETARLAWLSTELSSKRPLFAVSNLEKLRFPDSVVRTLETFKTASELEPEALGAYVISQCQTASDVLAVMLLQRQMGMTAKNGNMMRVVPLFETLDDLINAPEKLDDLFGVTAYVGAIKGEQEVMVGYSDSAKDAGRMAACWAQYKSQEEMVKVASKHGIALTFFHGKGGTVGRGGNPALYRAVLSHPPNTINGRFRVTEQGEMITQNYGTVQIAEHTLDIYTAAVMRESFTKHVAPKQKWKDQMERVSEVSCADYRHLVREEPRFVPYFRQATPELELGSLNIGSRPAKRNPKGGIESLRAIPWTFAWTQTRTHLSAWLGVGAGLTSKDPNDLKTLQEMYEEWPWFRELTDLIAMIMSKTDFSISKNYDEQLVDKASGLMELGEEVRMKLVETRQAVLDITKSTNMAGHHVALQRASSLIRSPYVDPLNVIQAELLKRLRVYESQDELTPEEKEEFDTLKNALVVSINGIAQGMRNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQH6</accession>
    <name>A0AAD2FQH6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001750">
        <property type="protein sequence ID" value="CAJ1948695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQH6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="298" mass="33856" checksum="FE550218FAC5FFCD" modified="2024-05-29" version="1">MENEEEPEITAPEKITEDKAKKMFLKDWYQRALDKYYGRMDHLENNISVLFNQVMQHMTSILRNKVKASKGHGEASSQSDLLWLLNTIGNIMSGYYVGVTPKDMALDSSLKKILTRKQKATETNEAYAKWMLKAIKTFERRGGAFLWTPSNEKELVAEVAAEKKVFNDAAKAAGSSSMTVDEESAVRCSKKNALKQHGIAMSILKRANPKRSRGAQTRPGQQVPDRDKRSEFGDEEGKTFLVKRALYGLKSSALAFRLNFAKTLEELGFYLSYADPDVCLGYHWMMNQHTFCVIMKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQH8</accession>
    <name>A0AAD2FQH8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS12172</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001384">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="5452"/>
            <end position="5643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1613"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4747"/>
            <end position="5335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4748"/>
            <end position="4759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4807"/>
            <end position="4816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4817"/>
            <end position="4869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4877"/>
            <end position="4886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4887"/>
            <end position="4896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4904"/>
            <end position="4936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4949"/>
            <end position="4962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4963"/>
            <end position="4974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4975"/>
            <end position="4988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4995"/>
            <end position="5021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="5034"/>
            <end position="5045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="5060"/>
            <end position="5077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="5107"/>
            <end position="5123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="5130"/>
            <end position="5140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="5150"/>
            <end position="5167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="5200"/>
            <end position="5213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="5214"/>
            <end position="5230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="5242"/>
            <end position="5253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="5268"/>
            <end position="5280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="5294"/>
            <end position="5319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1949588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="5657" mass="634611" checksum="51238F6A7BC90D92" modified="2024-05-29" version="1">[encoded data, 5657 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRG2</accession>
    <name>A0AAD2FRG2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRG2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025495">
        <property type="entry name" value="DUF4386"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14329">
        <property type="entry name" value="DUF4386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="33328" checksum="78BA14701C148873" modified="2024-05-29" version="1">MDDGEYYQPEPDPECRAEFMQMDEMKVQQHHVEILQEEVEELAMRGKRLRSAAVGAGICQSVAVLCSSYLVFAIRWMLLDWDMIDKTIYNIQSNWIFWNVGVLAEIVGCVSNTLVGVLVGMIMIGAGVNPASCSLIILFKLMEQVIVAIAIIAMIMVGIFVYEDNAMSTTIKYYFYSDSFPQIGMQISFFLLLLNKYGIIFSHVFAGLHYSFLGFIVHKFGVFPHKLGKAMLLAGPCYIINAGLNLLISRYNDQLHVFFALPGILVQFWLASWLLINTPSPSKNRETVMKGFNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRY3</accession>
    <name>A0AAD2FRY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001776">
        <property type="protein sequence ID" value="CAJ1951022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRY3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="228" mass="26329" checksum="69E0E6A12427B2C2" modified="2024-05-29" version="1">MDLMNLSHTNKFHSVKLDGYWHRFDDSDILCSSAKRSHTLILGNVVISDLVLILQDDHTIQNLKTLEYFEDDVNRESFISNEGEGRLVMETLAESEILASLGFRTIMPPNMNLVHGNAEKEQSIWTDRGDDPEAKWVKNTTVRELYWSGTNNKRWDWEWPPSAVVGTLLDGFANLKRLTLKHCGLHKLDSLILFLAVEDCCWDMTKYEFLRSKRNYSSTRFSTRAIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUK5</accession>
    <name>A0AAD2FUK5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001839">
        <property type="protein sequence ID" value="CAJ1953785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUK5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="890" mass="101631" checksum="8D786850730B7523" modified="2024-05-29" version="1">MPELTVRVQGDDDYESDDDNSGDEGDEEEEPIVADLGHHQENVDRGINHIRSLVTDLEDLQEPPEEEIKPREWPSSRSGSSANKNKNRVATRRKHGEREMKPLKDKLKPGIRTKEGSCSTKDSKAILEAQHNLCFQQIGNEMKADYEEHDAILIARCMMQIKAKFDTDEGLNFIQQYYINQGLKKFGDDGKDAVDKELKQMLLRDCFTPEFVKDMTASEQKKAQSATMLLAEKQFEKTIKGRLVFQGDGTREWLSREDTASPTALQEAITTTCVIDAHEEKSFLWLIDFVWDSSDGKWRFRWMHQLLPDHKLQIPGLTGDLEALRRLEPDEAEKTLGVMLAPLEDQQAHVAHLKSISKQWAEQPASAGAFLATWLLPLSDSRVWASLIRSALRCPNISRFCSATRPIKQKTGAYMEPTVQEHQLEIGTSFGLFQQDYSNTAILASDTWLKRVWKELEDLDICVALDNPVLPLRCEGDALLIEVFMELEVDQEALRWLNWCCMFLQVCTVSDIVTADGRSIRESMWHGERDYTHRSSYQWSRTVRPNRSHWRVWQENLTRALLASDGTQRLLRHPLGPWFDPINSWNWLWSSTHGLFHRQGHGWQHYCHRRSPTRSLQWDYTRPAQLSGRKRPHNEPANDGASPLLAPFWTQPLPEDNRCRRTTTPNRLYWPPGWPTEYVGWTPDEIEIDGDESLLAEALLEDRLCVISDGSYKLGLGTAAVQLLPRKGGKECIIVCCQTPGLTDDQSAQRSELIGLLAGIMVVDLLLDQWAPTLRSPPRVRIACDGFSALLNTFSDKRVTLQQAQFDLVSSIQEALARSRASWEPSHMYGHLDKATSFSCISWWSKRNVEVDDWAVAYRHQLEASHQLIAPNACFFTKLAALYIGDVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUL1</accession>
    <name>A0AAD2FUL1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUL1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042272315" evidence="2">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="108" mass="11290" checksum="659B796865F1257A" modified="2024-05-29" version="1">MRSINFFLTLLILAFAPPTIMAGHGKGNDEPTTSPAPTLKPTGAPTYTPTSSSTNSRKSSKKSGGMARTTSSVGKMETENASESTGSRVAQETALTVALGVSILFYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVX9</accession>
    <name>A0AAD2FVX9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS15128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVX9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="51"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="165"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="293"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1954535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="387" mass="41919" checksum="ACCB93A81C9D8461" modified="2024-05-29" version="1">MSYYQSQGRDRSRSRERDIPGGGMSPMAMANLTSFSPVGGMGNSAQEKINRELFVGNTPPGTTELLLLHFLNAAVRRVKIVQPHETPILNCRVNSKFAFIELTSADVANKVLNINGIPFLGAVLKVSRPSKYVGPHTPAKSWQELTGQSLPTGAVLDAEQEKISRELFVGNTTPEMSESMLVEFLGNAMEQVGLNAMAGNPINACRVSGKFAFIELRTAQEAANALNLNNIPFMGAQLRVGRPSKWTGPPDHHGNWEDILAKYMSGELQLGAAAAGGGAPPVSAPPPLSLATRVVELQNMLTDNDLVNEDEYNDILEDTREECGQFGQLISLHIPRKGEAGATKIYLEYGSNEDAAKAIAGLEGRTFDGRKVLAAFFDEAKFAKKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWH9</accession>
    <name>A0AAD2FWH9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001873">
        <property type="protein sequence ID" value="CAJ1954990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="266" mass="30165" checksum="082A730C8DC5A288" modified="2024-05-29" version="1">MGHSSSGGGRGRVTPQKVKSNSSSTVVKHLFSTKDENNGKARLSYKDAKERAIDYIQASGMKCSKDMVKSIRDEKSIDFNAIAPRLNAPTQTEADARETEMAQNKILYSAKLDENMQRSAYFETNKRTVKSNIMLKFVTEAMDIKLRGEADFTTTLEDPIKLLKRIERFTKKSADAEYDFLDFWEANQKFFAMKQGTTENLMHFKERFLRQAEVLQDLYGVAWFQNFAVKKKAYAAIASTNTAAQNKFKDDIFEAALATGFLCNCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWR7</accession>
    <name>A0AAD2FWR7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWR7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="415" mass="46178" checksum="7653B884E6BA926C" modified="2024-05-29" version="1">MADNRGMMEGIGGPVRMDQYSLNGIDPALDACCQRELESNRKYNALTSTLQRHDRIATAEERRRHARNLVKTSNFEGCRCCYDPNSDGGGDYRALIEYKQLKRQDEDQVQAQDEDAYGMSLREKAPTSVPDRPTESETDSDDDSDFDYLLDDDDLPGASANKQWEEARKAELEYQIWSNQVAMQHGFGVHRQHHPARVLKVAGIKGPKEVSSANARQPPPAVVLHLLDADALSSASLDYYLENTLAPANMGTMFLRAPGRGALQWNADSPRMKGTLIGQLEPDRDLPCLIAIRDGVVVNVCPNLREFSHSRDGEGEIESHAVERWLNQTGVLIARAPPVETLCYVRPEEDALNSYLGANTNISSKKAASEKAEIDYYCCGLEGCQKTFYHEHVGVETSEQSGLVVKEETVLETEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZV4</accession>
    <name>A0AAD2FZV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS16590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZV4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042004491" description="SEA domain-containing protein" evidence="4">
        <location>
            <begin position="30"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="735"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1957188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="84302" checksum="B95101E614C2F792" modified="2024-05-29" version="1">MVLRYFARSQLLLVSCLWCFMLLSPTVQAAKPRGSIGIRRREAKENKRDPETSSPTAIPTVIPTASPSIETNPPTIRPTKAPKKEQTEAPTQRPTSQQASRPTFQLHTVNPTLSFESSIRSLTPFVLELSEFPRNETAFNQLVERYLYVSMNAAMATLVNVDLQVLNTDRKLTGLQVKSIRMYHGSVTIRDPSVMEPSAKSAQTAALEDIATLNQFVSSSDIDLLITRVQVGDRDPVSIEAQKQNDATSSSPTPNIGLIVPVSIAVLLIVAATFMLVRYRRNKPPASPPPYVFEEDSDSSVSLDEGIPRFGKSRTIEIETETEQTSPSERASLRRLSSSKFMIQECLAGGGMEVVQLDSDGEDDRIVQLASIPMMSPSQSSIARSHSPSSMSVFSNSNDSTALRSSAMRFGRSRAVESHTDNSSAQLTLDSTKVVGALSMLASSSESCTDDSADEGGGYRYGRMEEPNEDIFVRRDTTRVSPSRTDSQMHQINCTKSEETERRFNPPNKWLAPPRQPPVTPLDDLLDDLLRSDSSTVADTSAMALESVLNPVRHTEEAGNRPIEVFVDSDSASQISEPEEEDYSADSEDGSSEAPQLLLKSVGSIRSADSFSSQQSESKTNLPSPLNLNQKLFGRNSNDQDHEPDAKPRIVSPTTSSHENASDEENDAPSDEETRFLQNRDSFEYSQTGSVHSERDIFDESTLFPTLNSTMDSISYSSSSVASQDSSSQFDPVFLEQLKWEKRRAKAATRKLKSEENQISFAMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZX7</accession>
    <name>A0AAD2FZX7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZX7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="3">
        <location>
            <begin position="304"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="DUF547" evidence="2">
        <location>
            <begin position="938"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1955741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1159" mass="130896" checksum="12336FFFEDC1CC40" modified="2024-05-29" version="1">MFHSSSIERETNGDSAGGSTESSASMASSFPQHVTVIQSCNPSNDQALFETFFGFKVEQQQQQQQQGDCQPQQNAAAPETIILTRNHQCVVLLPVSPKSPPSPSSSSAVKQNAMSILIFDESTMTNARTGDAAAMEGLPKVEWNTIPVKSKTNDEIIAVPTATIILSTGHILIATTLLGWKTPSARAKVVQFAATQQRLATPTLTRRPSFGSKLFSSVSKRKVALQRQSSLSSSPPSVSDDISEQQQQTPPNNKSTSEKSSRSFSPTNSSRTSSTNGGGIRNMNAKLFPSLDIRALTPGGEFGPFAANSQVEVPIESDLFVGSMILLIRPNDPTQDPYWNERIFSKKKRRVILFLQGKLKYTPEGPLYSGLEINQPMKLGLMASGLCNLILTFIQKFDPSLHYSFGDKEESAHMTSTVECFFDQIVVTHPGETPPKLGEDLNEPAESVKARKASKQKIQWNNQDTYSLAFHTMYVDFPSWTTSNVPLVRDMKLQTFWGNSLLNIVLYEMDHGQKRHIRKDIKYIMSIQLKYLKPHERQNNTEEEYSIGLNSSEEESSEMRGDSSWGALTVDDEVDFSFREDPTESAEVDESEEFFDTVQIDSNEGASLPNTPPTIGASFSPAFVLSAVDEYCPFMIEMHSQKKSYETVYVFRGRYSHSRPIFRDVRTAREALVDCRPSINEEWFSPRLTDIERTRRIIALMYMKGLTDKDVEIQQRTFAFQTKKSTYDRKFLKGFDSKKKNKKQVKPYFAVARALSDHHWVEEMALLSDRDIQFYRVDKKKPGFSIGLSSIIKVKDVDSTSMLQGYYHILAIETFGRTTYLMFPSKEERFRWSHDIQEKAKAKNGLLVSESLTNHLINVDDPAREFLHRSTMFDCSKRKILNCRRFSFQAPKPTSSEDTLLLAEQALIKATGLQSSGSDTALTDFLDCAAALKDANARDLNDDERMAFFLNVYHVVIMHAFIVLGPPKNGLEWLTYFNNFAYQCSDDIFSLTELEHNIIRAKMNFPSQFFSRFVMPKSQFGFALAVPDVRINFALNSGSLSMPTAAVPIYQAETINEQLDSTVLKFARRSVFFNYGKKKDVTVTLPKICQWFASDFGDGSTSDILKMLQPYLDQEKQATLERLWSAKKQAFDVKNVKFLPFMFECRFLTLEEQSNFTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0Y9</accession>
    <name>A0AAD2G0Y9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS17639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0Y9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000479">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="88"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1959218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="342" mass="39115" checksum="1567106AA858A537" modified="2024-05-29" version="1">MARAIDPALLQKVAIKQQSMEMPLVPEIIQPQWRNEKADDLKVEVKKEKPKDDDTARAHIVVQHHYHDHSMDRIGQFKQDNHPARGGVITPFPLKLHEMLRDLEQDGFGHIVSWQPHGRCFVVHKSDEFVHLLPRYFKLSKLASFQRQLNLYGFQRLTHGKDRGGYYHELFLRSMPFLAQGIQRIKVKGTGVRARSNPHQEPNFYKMSFVGTRSLSVPMPLPRSRPVASFPTTFMPIPSPMSLSIPTPVMSQPAPHASLPLQSSYSLEPRAVEDFDVICGFGNKKFHYLDPHQLQEAEKARKVEMAPQNAAGFFKDFVFPSDIGVEIEDDEVFGNMLEQMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G153</accession>
    <name>A0AAD2G153_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G153"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="499" mass="55745" checksum="EFEC910AA5EC07FA" modified="2024-05-29" version="1">MSIFLKKDRPNAKSTYYGSSLPARIRNGWNYSGNNNKKSSASSSSANNNASNHIRGGWRNMRARTSEKDKENHFGNRPGEHVTIEKDNQNHEEEAYCNAENTSATNHVIDIGNSNDATNNKSSGVGRARGGGGGGGGGPIGTEAMIEQHLERNSKLFKYPPQGYWTRIELSILYSMVLEPTIFPASAVCEHIQQSQQEFADAAADADAHRKTDPQQPQHFMEPYLYERPPPGQYTAQMTVSYQQFVALLVLAGEEWPAESKVPQLLCQSMVQCIVQYADRHGLDRQVELNQGLQKPLEQYSRKRGAKITLSSMWPVYVGAITTALTGTALPLGISYVASFALNEKHVQKECVAEENRLHYQLSMERAANPEHESLLDDIDHYDAYYHEEEEEEIQLWDDDEKDEKKEKKKNSGLFDDDDNNDEDYSFVAQEVKQQQQHQQQSKKTPTSALAGAGSMLLLGNSIRAQHQDEPVKKPAVYVKAVSTVDSSDEDDGDGDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2P8</accession>
    <name>A0AAD2G2P8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001965">
        <property type="protein sequence ID" value="CAJ1958061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2P8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="155" mass="17841" checksum="837EDC7226D05E01" modified="2024-05-29" version="1">MKFFDKKRDLETFQDGDQIAGVDDKEQGYLEEAFDQDYEPEDEDERDFNLHGQFDDIDDSKREELLADADNDVNDMPELTVRFQGDDDYESDDDSGDEGNEEEESIVADLDHHQENVDRGTDDIGSLVTDLEDLQEPPEEEIVFEPEEPQVAKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2U2</accession>
    <name>A0AAD2G2U2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002071">
        <property type="protein sequence ID" value="CAJ1960814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2U2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="1">
        <location>
            <begin position="94"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="278" mass="31294" checksum="50BA721B05E39F26" modified="2024-05-29" version="1">MLTLQAIGIIQYPKTTKRLCTYPDNRPILLVSGQVEKNLKRNPFLAGIFQVFQSQLKLDVLSKKEYTERKRDEGGQMKSQPIEISGGYILNQATQLNHLTANEFQLQNNSDRTCLRKKPRIGILNRRISAGRSIINADLLARTPVVQDFSHNNSVSVQYFEGLDFVEQVSFFRSIDILVASHGAQLTGVAFMNARCSHLVELFPKGYAIPDFFGSLAINSGKKYSYLYMSENSFGTEQSVSFADRRQARSVNLCPSPSMMASILGELSDSWRTCCEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2V4</accession>
    <name>A0AAD2G2V4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2V4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="191" mass="21462" checksum="FCF0F2821BAF8ABE" modified="2024-05-29" version="1">MKMLPPNEKFATSTYNDHMPYKAYFHSLLKSSGASRLELVRDDAMILGSADPLEDARFLLNHCAPPKVDSGLPSLPNRKPSVDNLLQLLSQSAPNEMRIAHGDTCCCEYPHHECSSFSPRTQRREQTNQGTRKSWPGCSERPSIREVATPEECDIPPTAPTRRREMPARNFNKRKHCRWSASSVPATKVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3E4</accession>
    <name>A0AAD2G3E4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002070">
        <property type="protein sequence ID" value="CAJ1960809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3E4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="604" mass="68055" checksum="C568789836B82F78" modified="2024-05-29" version="1" fragment="single">MGKSINAKASSAMTKKSGVSKLKTSSGAKKSVKKRVEIDLQQPKDRDPIDSKMVPETQTDEKRVIDDNEAQRMADEIEAKRIAEREACRSGHYDSIVPNLSEWWMKNLYSGDAVDEALERHDRIHTGNALFMAWEERFPAAWNQPCLRYDDPFNDNTGTTTCEDRFARIFTTMNSDNSQLTQYLIAAFDTETMEVNPSEEIWSLRILAMRISLQNPFSFFGIDEFEGKPDDNHFFSGEMSNPRLRLEHPLVGFWLICSELFDYPWINEFLLEYYDDPPSAIVDAIKQTRSGKSINNAPNRESVKEPDPPRIQKIYDPMYSIDVPDMDVQRESTSSKGDQVQNSNRFAPLQSDDDSFDGSGIQEFDEVEVVAVKKNAFKAPELSDEDEDTEADDTNDRENIVDDAMEEDDDDKRVNTAGANPHDEAMDDNTLPLTSPKLTATQDSAGTGTFMEPSETTPSRVPRPPTLAERISNLIQVNKEGIPGKCHIFETTFSMDYQGSDSGTVAEALLSTVLKSMEEAINNSPNELKLLPISDTTYKQPNLWIQNSVDLRNRISTYRALSTYCDMEYGNCPYAAANSKPGEKKLRTRIRVGFSAEASVEAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3L2</accession>
    <name>A0AAD2G3L2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS18446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002037">
        <property type="protein sequence ID" value="CAJ1960030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3L2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="592"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="673"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1960030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="881" mass="94945" checksum="9C577F5A53B431AA" modified="2024-05-29" version="1">MPGKRAADMLANFKSSLDPSSGHSGSSLLADIREGAERLANEVDEYLESTNHSSINRRKESNPLSDEGIADLQLVTARKLRELLPQSRDLLNKAQERNWIPLLLNWLNLHDRPAVQVESLLALTSIAELCAQQSYYQHTQAQSSAVAAAAQAAAAAVKGSSSSASSLYSLGNNSGQKNSTPATYPYPPLVAPTPGESVPFPPLSFSQTLSPEAIAAFDASLTSTIQNSRVFEKGKGNKSSFSLPSAALFESPDRLPASAWTPPTGGINFISLAPPPGRVHHAVPSNAFLPPPTPVPGPIGGSMTSFPQHLSPSAQHLLLRHADAIPTLISLVSSPNREVYEQALWILGSIAVGDSAGSNSSAGNTGASGLEGGRDKAVFARDVILAAGAMNQLIRCLEAHPENLSLHRIGSWTMSNLVEGLFQQPSQGKNGNKSSDYCSRDEIEIHSLLPLLRRLLHMADSEVLSYTCWTLSHLCDGPSSHIAEVVTSKDSNSPKGGLVPRLVELLLHPSWRVTKPALRTIGNIVCAECGDDNNSHSTTTDYTEVILECNAVPRLKDLVTHGNREIQKEACWTLSNIAAGTVDQINAVIQSGAIKPLVELVQGENTDQEVRSEACWVVLNATSCGSDAQIEILVDEGCVSVLGVLLSEASMVMMALEGLERVLQVEETREMMRTSAKSEELWAATEEKTENKKTSSKKKNRKKKEKQKLKKAKQDAVLPTGSKKDSEVSTEASLADETSKNQDEKEDGGREQETQAEENVEVASSSKPSGLTSKPSGDAEMLQGHQPAIDFVLYLQQTGSIIALAKLMDALDYGEHYAEMAQIIAIGEGWEHDTKDKVPPSCGNSTSSSIEALYQKGGSFSGCFFLVERKILERYYNYIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3Y3</accession>
    <name>A0AAD2G3Y3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3Y3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="866"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="920" mass="100387" checksum="3DE14184B5E73193" modified="2024-05-29" version="1">MNVIDLCDSDDDETDSRDTEKKHQRLHINNQNSQSPSSTAAPAVAVAVAQRPRSISSASNSPLGNNSDDVVFLSDDESDDEQQEVNNLVHQRRTTFSKKKPTDKPMSAREKSWALIQQMRREAAKEKEKSKALSSTASTKAARGPQKKSPPITKVNPRWNDKRKRKRSNSNLEHRKKAPTASSTNPTSSTSTANINDNAAPRIIPSFLEQGLKDGTTNQQGSGGENVATASLLSPLQTAMEVHDSFEQPFIDDSMNATSQDNPAAHCQMETITEPTASAGATMNAAIEIDSDGDSVVDRSPQEDTTRCATNSSVAATATDYHPLLQLASARPPAEQRHGGDDNQGSQTFRAPRAQDNSKILNDLMDSGSVAHILDHRFNNGKVTFVVKDHYGAVHKGILLEDLKVDAPLLLSNYILNKARGKLAGKGFREWAVKTRNQLAKKAMRHIATQERVMAGEMNDGLPEPDTGTNQPGAKSVGRSSHVPISTHDDADDAEEAEFEMNAPSSCSTQSFERISPNLPPVPDDPETRDDQIQTEDSPEQSIGPIATPNVQEEGSISDMSSGNDDFEDTLDTESSSGSLQMTSQGGTSENDKTSMQIGQTKTSVPDLDEELLLEQEDDSSIQTEPRTSEDPLVGSRPAYTAAEVAVEIDEEEEDDDDVIEVVGVKAPPRIENLSPPTPQHRTSPLAKEMPLDTDDDSVCSVQSASPPRSSSTRKPLVGSSGTPIDIDDDHGVIPMGKKMDTTLCTMRDFCAAGKRKNGTKRPVPTSYSYPERRFVFHQTLPKRPPPSARRPTASTWAYGISCDAAMKEQERLFQASAAKMRSQTKAPTTARVTTTTSVARNQIVKFQQVVPNIAQKYPLHWQFSNHFARLGVPEGSSGSVIKKQYRRLALIYHPDKSQLANTATKFQNITEAYRALLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7Z1</accession>
    <name>A0AAD2G7Z1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002238">
        <property type="protein sequence ID" value="CAJ1965957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7Z1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="355" mass="40482" checksum="3206407B7F76A3E5" modified="2024-05-29" version="1">MVAELGQYVHAIGTDSNNSMEPQSIEAIYIEPTKGQHTGHRVLNLNTKKMISQPKVVVLPRDLETFQDGDQITGVDDTEQGYLEEAFDQDYEPEDEDERDFNLRGQFDDINDSEREELLADADNDVDDIPELTVRFGGDDDYESDEDNNLGDEGNEEEEPIVANLDHHQENVDRGTDYIESLVTDLEDLKEGEIVVEPEEPQVAKVTRSGQTYAQAAMSTTCVIDAHKGRDIMTLDVPNAFIQTYMPDAKEGEDRVYMKITGMMVQILIDMAPEYCKYVVLENGKREIYVRVLRAVYGMLQLSLLFYNQFQSDLEAKGFVFNLYDPCVANKVVNENRKLSDFMLKIICQVTWIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8A9</accession>
    <name>A0AAD2G8A9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8A9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1065" mass="121041" checksum="EC38CE286F783CDC" modified="2024-05-29" version="1">MVRIREGREFYDDLYETPDEDYDDEEDELKKLTFPDQMVGRSKELEQLHQLYEKFCGEKKRESEKLPLLMISGWSGAGKSALVSGFRKELEHKQLKRKPLFLYGKYDQNLPGQESSTLAAILEAFVIFSKNLEQEEDLEEKTSILASLRAGMHDDIETIEPLLPRLAKLLREDTDPASVPCAGFTWDRLQYLFKSLFRSLCSGGRPLILYLDDLQWADQNSLELIEILLKDQSLKNFMILSCVRSSSIADGGLNKWLSLLDEDRIEKMELKSLSLEETGLFISETLELKPEETSSLTMAVYNKTRGNIFSTIQALEELYRKEIIQFSVISFNWEWNVKAVERLQALLSDDVLEALISKVETLPQRLQMILAIAAYTRYVFEIDMLEYIIRCDECCKVDSRDELTALLKKAVLEGALTQSVGSPRYRFTHDKIRQALQSVVSSKYPQLIPTIGKLLYEFAKEKRGSDWMYFAASNYIHPSAESEDPAFLAELFLESGQRAVRLAAFAPASKFLKQGLEALGRMETPWVTSYHLTLNLHNLLADTEFNLGNLDSGKEICDIIVENASSLLDKLHAYHSYVMALAKNLELEKSKQVVCHVLELLGERPTRLKGAARFLKLRKVKTYFKKHSNEDLLNLPAMTDERLVWSMKLYMNLATRAFQTNDKNFSLQLSLKMIMLTEANGLCGASALGYALYARHLKESGDYVHAMRFAELAKEVCKRFSANRIVSYFVIEYIDCWCLNPASCLTALQHNHRIALSKGEVEAAFLLSFAGNKLAFDLGYPLRAVERRATEILDEAKLNQMALYADRVKYNRAVVRYLLGFESLPLDWDSIGGGDIDFDNEYLLMPFYYSRLQIGFYFGNLEFAERMATRLDTVLVADNGFTVMSNALFFPGLVFSGLARQTGKRKFIARARIYRDKMETLLKAGAVNTKNKLLLMDADIFACSSRASTRSIQAKYDEAISVAMKSGLTHMVALGSELAGEFFLSNRQDEEVARDYFSRAVEGYRLWGARAKVEDLNNRHGELISHAQASEAKSTLTSSSELQMCDNSKDLELISVHTSLNELPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8U5</accession>
    <name>A0AAD2G8U5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002272">
        <property type="protein sequence ID" value="CAJ1966316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8U5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="55"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="381" mass="42609" checksum="B86D4F725C8ABA0F" modified="2024-05-29" version="1">MSSRNGVMYNALSTETNQLNEGARTDTDNNLKPLYPLKGVDCNGNESQDEHVEYVEIIILDSAQNRFPVDVSPGWTVKRLKEVSQQIHKVNPQSQRLVFRGRMLEDDTTLEAAGIEENGVIVHLFPKPRLVVTSSAGEESNTREKTMLVGAHVPQIVLDEEEQERRGQILVLGSVEIAEAQNNCKLLSLLLLVVCSMRLLVLLSIALGTPTEGPHNDDVDQGNSTAHPDEDNQPQSRPWENYDYCDLLVSALGFYVATLGMKATTENTLRLATAYFVGTAAVGVLWNVWNIFVYSMFVKEKSSPEDDDEEPLTRDDYVTVAVFTVALPMMVWGLCVARAYEFRKLIEEAEIEAIGRIRRHSHTDEEAELDENVEEGRSTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8X8</accession>
    <name>A0AAD2G8X8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002298">
        <property type="protein sequence ID" value="CAJ1966539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8X8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="381" mass="42819" checksum="A282F37F251CBC27" modified="2024-05-29" version="1">MCCNRRNGGGHGGRGREGRGGRGRGISAVHDGRGDQEETKEGSNNESNNDGRTCAFDPAGCCVLSTSSQSINVTGFHNGLKINDVRIGNVCLAYDCPFDHQTYCLHFCEVLLIPGLGSHLLCVDQLRANSVVVNDVPLIRLRPEQRNREAHAILTSGIRILLLFDKPISYFTCRQPTNEEVSDIMEFQPVWMTADIPWQPYDPDSRRQEEALQQQIDADYQAPYHQLASFTRLDSTLLTAACLDRLPQVLGDSNNAVCGIHSLTIRSMKTSGKSYLIKPDQLARRWRTSIECARRTLEKTAQRAIRDWLVVQGSRRFRPVQYQLEYPRLKTNVYVDVKFGPCKSAEGNTCVAVYATPVQWARAYPLNKESDVHTSLTQLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9S2</accession>
    <name>A0AAD2G9S2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9S2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="98" mass="10642" checksum="928E1593CB72465E" modified="2024-05-29" version="1">MPRHSPLIGMSEVLVPAVPGDKDFLNHLEGNGDNCKFADNEEIVNAFSKQIPPNASDPKCVDSLIANQMTKLSVADREKACMGVHGMPKLVEETPELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBC1</accession>
    <name>A0AAD2GBC1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002402">
        <property type="protein sequence ID" value="CAJ1968682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBC1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="430" mass="47993" checksum="92E3DFB96E77E1CD" modified="2024-05-29" version="1">MVADLGDAIHAKRKRLLQNCDAEDLCIYGKGTTMGNYRSKEPLMIIVPLNDKEIQGTSITDPLLVVVPVLKQQRARLSTIENNGGLPPMTPRASTTRAFVPPSMGKDKADIHVVSGPPSTSEGKEEGLAYASLDDNTHMQCTSHPLCVELLEVLEEAIAKEKNRNMDAKFRHAASYVHQVRKWSGQDDNLPKGVAKNERIYTGVMATAIYLVYIKDVTDKSWPTTLLVGEGKNGAIELRADTRGQLVNQLLCHCAIDTEHLEKDINGPVLLLAFNLETVEIDLAFPTTFGGKLAQDKVVSLQDKNTDQKKEAFWTVQIVRMNIAPIQNLSIMLCFIARGLKKVDAQQYKTARVQMKMPTAKSDSWSFGNDMGDVCYYGKNVTIQQPKFVFKEYCYHLRQKDVFMLPLTIIANKDKRRPPSQTLLNCLGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC83</accession>
    <name>A0AAD2GC83_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC83"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="300" mass="34569" checksum="DE9E052AB7E58C30" modified="2024-05-29" version="1">MEDWATSSRSQARPPFPFHKSTYPFDGSKVDSTYPFQASDEELLSMYAEERARAQRARFEESKEETKEEDDVLDHRFQTSFIRPGSEQSKEGDDTLDNRFQASSIRARSVESNEETKEEEEFVEMDTGFTQCLDYYEEELEIDPTILPTGSANFCIVHYESYTPPPISWIIQAIYSARHDLRFKLKTPQGAYMLLYTDEIINCVLVLIDEDDGSAYFQIEDLYGNILFADCDQVEAHILYIISTETRKRQATVEHASMDRETFSQNAKPKRRRKHSGPLVSGLRKLSGLVKQCRTSSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GC93</accession>
    <name>A0AAD2GC93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine incorporator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS23608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GC93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1969244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49509" checksum="DD1F849C39CD03E2" modified="2024-05-29" version="1">MGAIISCVATTATWCFCSALMSLFGACCGNDKPSSVAPGAFSGRKRSVFLLVFVVALSFAFQYGVSQVMVNLSPGVNYVTEAWWGGCEELETERLQQRCIGNNGVYRVGFSAAVFFLLATVAVCVNRTANRVAWPAKYVLFVFLAVGMCFVPNEPIFSPIYLNIARVGAVVFVIIQQVIFVDLAHNWNDGWILNSDKAEAEESGSGKKWLGAILFSAAFLFICSIVGWVLLFHFYGGCQLNTIFIAVTVVLCILITMAQLSGEEGSLLASGIITAYATSLCYTAVARNPEAQCNPFLGDEDILGVVIGVTITLISLAYTGWSYTADSTLGKSNNEDQQAAEEEAAAASKEGGRPKIGGIVTNEENGDGDDEVRDDIDAAADIPDTFSNNWKLNVVLGTVSCWFSMAITAWGSIEDEGDAANPQVGKVSMWIIIASQWLCLTLYLWTLVAPRLLPDRDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCL5</accession>
    <name>A0AAD2GCL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042231064" evidence="2">
        <location>
            <begin position="20"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="496" mass="53712" checksum="EFB76F17D80595CF" modified="2024-05-29" version="1">MVMIKSSVLLLLPLTVVNGDEGMYYNNNNNNNNNAAVNSVNNFGGQSLTSSSNTYSNPQGSYNSQYTNSNSNMNGNLSGMTQQIPSGAAGGGNPFGGGMDQGDDFIGAMSSYGGDMMTMMFGQCLNNIDMNKLMDDPFADVKNRCNAQQATTFNSALDSFKTCAGFDLKELIEDFGSMYIGLLLNCGSYFVDVAQELDDIGMGIEDMEKLKAKESPLPRVPQECVDAMVGDNPFGTAFLYAEEFPEREQKCFSEIAGKLPMCTLSEWPVPIVGNWLSAFSCIYGNANDVIMPLMQDSLTQELKMLNDCIPSEVTQSNCKDIRNKCVFEFDTPAMTMVMPPPFWAPPMAQKSKDIASAQFGDLADRYEAYRQTCVPPADMAIWDVAAHHMEKNKGVSGGATYFMESSTSEDEKKEKADGMEEVEEEAAQLGAAAAPPAAAAKTSSTKFMPGLLTGMIVAVAGMFGYNKYRNGGGHMPMNNMGYQFNSLELSEGPGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDD3</accession>
    <name>A0AAD2GDD3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDD3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="224" mass="24467" checksum="3FDD32FA8D7BDF66" modified="2024-05-29" version="1">MGGTTTIRYFGHLCLAKICYICANSLSTPPSFAYGDAFLANALSSGWKIYVLCLGRLLQWGPDPSRHGLSDGVQPRQRLELPPAGPPPGPPQPEHTVPFTAKKPLFKSLLPVEAGQSVYEAVLMKKLVRGDSPLLLNPQGTLKTRFVFVLRLKGLARVTTEQGFVSPAALRNLKAWDGIVCMLILQILDGMHPLMLKQIGPQWSSLSNCTKRRAFLGPLLGSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDV5</accession>
    <name>A0AAD2GDV5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-pyruvoyltetrahydropterin synthase</fullName>
            <ecNumber evidence="4">4.2.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS24004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.12" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040002444">
        <property type="protein sequence ID" value="CAJ1969980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDV5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1969980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="203" mass="23106" checksum="203A4C3FFD32E241" modified="2024-05-29" version="1">MSGLLNIPETTFEVNVSKETFKFNCGHFVAYKGFRERLHGHNYKLAIRLFGSRRIGQDGYVLDFGDLKAVTKKVCKNLNEYFICPMYSDVITITDDDEGENVDMTCEDGSKFSFPKADCVMLPIVHSTVEEIAMYCWGQILLGLDAQYLVKRGIHTMAVTCSEAIGQEAIFRMKIPDTNEKDEILKLCDVRTYIMQGELLTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGD9</accession>
    <name>A0AAD2JGD9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGD9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="629" mass="70815" checksum="4E14A16C27ADF75D" modified="2024-05-29" version="1">MSFVRRRSRADITNRRLLQEEEEEDQAQLFYYSGIERVPNDVTVVHLHESMKSLPYQAFYLKKVLRKVQFHDTSLRTICERAFASCSALEEAILPNSIEEIERGAFSHCTSLHTVYLSPRVQLTVIGRGAFSYCKSLVSFQVPPSVHTIERAAFTRCDKLQHVEFVSSVSASAEVPLDESSPSSCDKKEPLLLFESQLQCIDSIAFGGCTGLQTLRLPHGLIQIQSQAFSGCTWLDAIEIPATVEELSSLVFVGCHNLKHVALPPDMDLSEMPDDVFQECHLLNPLVLSVMKGAEQANDDSDRPSQVLQSRFEGLPIHELCYYSQDQEVLEQLLMLDHDDGNLSEATQDCFGMTPFHILALSGNRQKAVLDLLKLLLKDPRFQTVVTKKDMWGYFPLVYACQVDSPLPVIKLLLEVHQKAAIASTTKMEDMVVDDSAAESPSTNQATNKPITVPWNHLVRHCASNSVKNLRFIVRSCLKDRIQRLGLQQWKTDVTFGIFQIPVDAHPEEARTEHIRALCRQLAGFEEREALAILELAVWKGSLDRAASAQENESAAEKINDQNESEETANDKGEKTDAQGSSDNAFELEEDSPEEILRKTRHSCRVTCNSDVILMHVRQHFKIPPTDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHG9</accession>
    <name>A0AAD2JHG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="90" mass="10377" checksum="FEAF18979A37FA09" modified="2024-05-29" version="1">MSTSTSNTRINFSYPQHSSKWCDNDEDYDYCDEYDDYDDFNIGPTTTASSIASRRQQPKQGKSGGSIYSAKHIRAKEAMQKRARQTPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHS3</accession>
    <name>A0AAD2JHS3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001764">
        <property type="protein sequence ID" value="CAJ1950376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHS3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="345" mass="38171" checksum="3B302C40BA561812" modified="2024-05-29" version="1">MFTACLLHYNLDVATAVRYVGNIHTGAHRDWNTLEPELRAASVDDGLVANLRRVLVGGCPNYVNATSSEKNRRSFAEYGNHDSVYTNVEKTQKAVQKDFARSHSLVGNPLLTPFLPDTQQTPQGLVVVPGKSDRQICDGTFCPLLESIATNDMTTKDTEHKVKFPKSLRNHLAYIYNARISYKSEELYLGDNDVSGAFRHGKWNPNVIGMHMFSIFGYLFFCTGLTFGGNTCPSNFEIIALSRMAIARFLWSQASTIARVLQYLPAISTSPEPTPDEIAQFTPAEADSINKGVFNPDGSRIPPNFDHHVDDCLYVDVAKTLRQTIASSVLALYLILGFPDASKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIA1</accession>
    <name>A0AAD2JIA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS14291</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIA1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="66"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="247"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1953688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="408" mass="46551" checksum="27DCBE7E124D39F0" modified="2024-05-29" version="1">MSEEEQRPPAEEEAGAPGGELTDADFDSNWDEAIETFDGMDLPEELLRGIYSYGFEKPSAIQQRAVKPAMMGRDLIAQAQSGTGKTATFAIGSLAKVDRNLQECQALILAPTRELAQQIQKVVLALGDYMEIKVHACVGGTAVRDDIRTLQAGVHVVVGTPGRVFDMINRRALRLDSIRQFFLDEADEMLSRGFKDQIYDIFKFLPESVQVCLFSATMPLDVLEVTEKFMREPIRILVKKDELTLEGIKQFYIAVDREEWKLETLCDLYETLTITQAIIYCNTRRKVDWLQEEMQKRDFTVSCMHGDMDQRERDIIMREFRTGSSRVLITTDLLARGIDVQQVSLVINFDLPTNRENYIHRIGRSGRFGRKGVAINFLTEGDVRYLRDIEQFYTTEISEMPMDVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JII7</accession>
    <name>A0AAD2JII7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS14481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JII7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1953884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="591" mass="66049" checksum="50031E9FD0220876" modified="2024-05-29" version="1">MTEDDDSNVFYDKRRRIYNIYRTGLLVFTSLYTFFFAGAFFGYGPMILLLQRDEAFFWKCDDENEEPTCPDQKSQLLNIHFVGTLMQILTPFVGHLCDTRGPFATMFYTAATALVGIAVLIISRAIPIDELLYPAFCFLGMNAFATSVMCVATGRIFSIYSKEQVGQTDMGKMEEAKVPQELDSADSMTRSLEVSEEAKKGSDKDQGDADDDYKSEEQDDGSQDKGPRRVIGFLNNLFDAGSVTYLIMWVAHKNLGTSLQVLCYWYLGAGVLIFGGTLTCWMLVLKHQQKDKELQEEADRIRKSIVTIAEGRSTVLEMEKQEAALQNDHVDDSSTKEPQILASTEHANREEVMEDDSKEEWRELFSASFLWLVAFFAFHVARNIFVLTSAEAFLKDLGDTSDKYISIFTMMMPASVLGFPFVDWALGKFGYHKALQLINLFGLVHGIIQISATANLDIQIIGFLVFSFYRCFLFSVIFAYLSALMPEKVLGKANGFLHISAGAAGLLNIPLGNAAVQQWNGSFFIPNCLYTFGILPFFYAAYGTTAGIRSKQNQRQNSTGTTMGFSKRLSSLFGNSLYPSLSATDDEVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIV1</accession>
    <name>A0AAD2JIV1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001854">
        <property type="protein sequence ID" value="CAJ1954063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIV1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="32969" checksum="A7C1FAB03F134DA3" modified="2024-05-29" version="1">MSNVFHDAIKGKDENGKDVYLIPCPAGTTNVKLQADWHYASEDEDLPDLATEADRGLQFIQSRRKKRDPFGLYDHVIMDSGCTNTTISNGELMHGLRHAEKELDMQTNVGSRVLDEEGFLGRFPPPVYHDEVGIANVLAMREMIAAGYRITMDTDADNAFIVQCDGNRKMRFVNRKGVYVLEQLGANVKPGAKETSAMYCRQLSNLNNQPHFELSSNRQNGYAGLEMTSKMVTVRKNKEGFAPRQVKATMEARSAMHILKAPSTKSLKYAIRSGLIKNCPITEEAINHAKASLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ80</accession>
    <name>A0AAD2JJ80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ80"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="283"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="553" mass="64546" checksum="012523B0A1411A45" modified="2024-05-29" version="1">MSLVATGRIDAKRSLSRSIAQQNRSYFFVPLTWVEFRERFERWIKPTDPRVVSVQVFSRKILQQENQKYERISKTPILRDKGKWGNWFKNRNKKMGYYTPALPLPNPKGTRMERLAERYQGWKSRRKDDYAGWKARRRQDYEGWKTNRKERFENWKSRRLLKTKEIVVKEYCQPDWFDDLGRPLTSRDSTGRFVNPWQSQTTNGVHSLGTLLTWRYIRLRRLFKQYVWQYENGMGNTVNAMPQLRPQQPMPPLPPLDRNDTSKVQLTWIGHATCYVQLHGVTILTDPIFSHRAGPAQWAPFGPCREVAASHSYDELMTHTGARGIDICCITHDHYDHLDYDSIQKLKGNVETWIVPLGIKEWLIVNGDISPDSIVEMEWWDQIHLDFRDSPVRVLDGPKEVDDSNGKPMTITCCPASHWGSRNMSDRNTRLWCSFAFESNDQRVFLSGDSGYPTFPLFRQIADTLGPFDLSTIPIGAYEPAVMNKDSHANPYEAVRIHKDLRSHRSVAIHWGTFPLSEEELYEPPMQLKLALEKEKVDENDFIAIRHGSSVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL04</accession>
    <name>A0AAD2JL04_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL04"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008557">
        <property type="entry name" value="PhoX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35399:SF2">
        <property type="entry name" value="DUF839 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35399">
        <property type="entry name" value="SLR8030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05787">
        <property type="entry name" value="PhoX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="746" mass="82433" checksum="00B93CA4E7C27F66" modified="2024-05-29" version="1">MSPQHSRQHSHQAEAQAEAEAEQRAIEDASCHQSAASWIDFTSSWNAFNSTASNWWESAAASWQPTLREEHEGDFPSTLPVAPGSPASFHTAHNNTGNDESGNGHGHGHGHGQGYDGSYLARVKQDANRHPYHSKSKSKFKQSNHRGNHNNNNNNHNAPSPSQAMRLKELSKLSSHTVDSSSSLSDVQQEGDNQYNSSWYAQGGSRLQVFPSNHNGRRHREGAQPEDGDDDYDYPHKPSSHHFCFGIANKSNKYKFAVLLVVLAILACVAIITLTSVDISKDSNNLDNNMDNNGTNNSNNDSQNLLANNGVPTKAPTQTPFPLATSNPTPFPTTSAPTTPPTEETILTYIPGKLNVRSNGLLLSEGLTSRVIAISGQAVELTGLPPLQTATTTSSGGTNQGASSSLSELQYYKSTQGFHEKPDGAAVFPWAETGGWVYVSNSEVKEEGQGGVGAIYFDKEGKVVDYQRLLDGTTMNCSGGPTPWGTWVTCEEVDGGKAYQVDPFGIRPPELLSTLDTGFFEAFAHDTRNKDKPAFYVTEDKERGPLRKVVPDNPDWQDPWQILHGAGTLEYLVLQPDPQDPNNMSGTYYWTTEREVAKVNSQQYYKHSEGIDVYNHELFFVSKEQKELFILNLDDGTYKVHTTVSGIFDGHPDQMKRLIHNGLLYFCEEGGKENGVHARDENGWFFTIAESDTLSDETTGLAFSPDGMHMYVSYQHNGLIYDIYREDGLPFHGRTLNVKYHQIQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMD4</accession>
    <name>A0AAD2JMD4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002157">
        <property type="protein sequence ID" value="CAJ1963658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMD4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041981651" evidence="1">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="69" mass="7623" checksum="D38AB62FF2015CFC" modified="2024-05-29" version="1">MICTNLLNDILVAILCGIFQDLFLPSQSRTYSETVGLHSANLLLAWCNLRSQVHISGDIPRVSYDGSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMU5</accession>
    <name>A0AAD2JMU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="355"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="473" mass="54348" checksum="911381BF33D5126C" modified="2024-05-29" version="1">MNMVWGKKESSKHDDDDDDDDNKRITGDVPANMKEEDNLDSLIAGALNQLSINEREHIYQEMHGVDDIVNETPVMLQRSMMALHTELERLKHTPSHNREGLAFNTAEAISRNYVNDPFFRIKFLRSEKFDVKKSAARMIKFFDTKMQLFGKEKLCKDITLDDLNSDDMALLKSGYLQLLPTRDRSGRVALMMFFSERKHKVPENVARVVFYLIMTAVEDGETQQRGVTSLSYSDWKFDLKKFDLGTLNVGAVLEKCLPVKTCSHHVCFSQPEFRFIVNTAVYFMHGAARARIKLHWGTHMEVLYELMAFGIPVDSVPVSTEGELKRKNHLDFLKMRQRQESMVGAPRIVIPTHKDVLFGRGKPFREHQGNIILYEMIDSKLEYYESASTKQKTAAITEMVDAVNSSGGRFLKQDVAGCWMAVDPKMAKEKVSNTFRTRRRIASSENEDRKNSEFKVVSEGKKRFRKVSSDVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN35</accession>
    <name>A0AAD2JN35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS21805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN35"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF60">
        <property type="entry name" value="RH50, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="61"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="441" mass="47163" checksum="B319E5C71982E4F1" modified="2024-05-29" version="1">MALSESTPLVPSTTSSSTEEVLDFAKASTKTLTLLLGSIQVFVLVFFLFGTTYSPEDYSPSEYQVFRDIMVMLLLGFGYLMTFLKKYGLGAVGLTMMLTVIAILLNVPVELFCRFLFGEKEDTSFPLPLKVPTFVDGEFSAATLLISYGAVIGRASPVQLVVMAICQSFFYAFNKVVIVLGFLGAEDVGGSMTIHMFGAYFGLAVSKALGPPKVSSSSNAEPSQVSDVFALIGTTLLWVYWPSFVGATETGVSLNENVCVIHTVMALLGSTIASFYLSQKLGHGKLDPVHIANSTLAGGVAVGSSARLAMTPGGAFLLGMAAGVVSVYGYKYSTPKLEEKFGIYDTCGVGNLHGWPSVLGGLLSIVFVAMNSDAEFLNHEALTQCVAQFLAVLSTVAIAASTGYVTGKVMMKTVGEAPDEYDDSLWWEGEYFEAEEKKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNE7</accession>
    <name>A0AAD2JNE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BspA family leucine-rich repeat surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002280">
        <property type="protein sequence ID" value="CAJ1966403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042026298" description="BspA family leucine-rich repeat surface protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="44736" checksum="EE900433AA3AAD32" modified="2024-05-29" version="1">MFSLSFLMVTTLCCCELVSFSNASSSSAFSCSNNGNVLAQQSAVNIMQQVTNNGCACFGENYELHDAVDQFISDGCSDTNNCNNTVVQKYGWPMGSWCVSSVTDMVFLFLNENSFNDDISSWDVSSVTTMDYMFSHASSFNQDLSTWEVSSVTSMRGMFWLASSFNQDLSSWDISSVNSMESMFQTASSFNGDVSTWNVSSVANMNLMFAGAYSFNQDLSSWDVSSVTDMGWMFQGASIFDGDLSSWDVSSVTDMTWMFEGASSFNGDLSSWDVSKVTNMDLMFAYASSFNQDLSSWDISNVTRAGAMFEGDGAFDESAVCNWSDVWKRVFSCDDESASPTNAPTLDSAASPTNGSPNPTNAPTSDNSASPTNFPSLDATLSPTVDASSTSSFNSLHATILLLVAANFLWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP63</accession>
    <name>A0AAD2JP63_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP63"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="152" mass="16974" checksum="DFE8A7D5C479B540" modified="2024-05-29" version="1">MADSSSDDSDEWGTEEIVIPSKSGAAQNQSEEGENDDGDWDWDVVIEKKGPKLSTVQTAPKKPGEPMIIVDITQLDENVHSKFDRNSVNNTDAASAWRKKIENQYQTYSKDAKLLGNGTVIPCGSSVWRDALVRLRDERKGHYFCPVFSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPS2</accession>
    <name>A0AAD2JPS2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002494">
        <property type="protein sequence ID" value="CAJ1970316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPS2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="347" mass="39644" checksum="3CCD6CEDC6FDAF19" modified="2024-05-29" version="1">MMRLAITEQWTFKRKNQLLPDHRLQIPGLSGKFESLRRLEPGEAEKTLGVMLAPLEDQKAHVTHLKGIAKRWAEQVASGHLHKYDVIPLIKSTVMKSLEYPMTLLTLEAATWVDIMSPVLQVCLPKAGICRSFPCDMVFAPLKFQGLGIPHPFGSQVSKHIETLLRHSTNKTKTGAYLEAALQEHQLETGTSFGIFQQDYCNTAVLASDTWIKRVWKELENMDIYVAFDSPALPLRCVGDALLVEVFMDLEVNQDDLKWLNSCRMFLQACTVSDIVTADGRCIRQSAWCGERDGIHRSPYQWPRTVRPNRNHWRLWQDTLTRALLQSDDPSHHLRQPLGTWFDSIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPT4</accession>
    <name>A0AAD2JPT4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002489">
        <property type="protein sequence ID" value="CAJ1970257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPT4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="220" mass="25552" checksum="4C02F3BE8E5CB476" modified="2024-05-29" version="1">MKADYEEHNAILIARCMMQIKAKFDTDEGLNFIQQYYINQGLKKFGDDGKDAVDKELRQMLLRDYFTPKFVKDMTASEQKKAQSAMMLLAEKQFEKTIKGRLVFRGNGTREWLSREDTASPTALQEAITTTCVIDAHEGRDIMTLDVPNAFIQTYMPESKEGEDRIYMKITGMMVQILIDMAPEYRKYVVLENGKRVIYVRVLRAIYGMLQSSLLFYNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUK4</accession>
    <name>A0AAD2PUK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUK4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="42007" checksum="21F1229FDFB40D25" modified="2024-05-29" version="1">MTGNKPSSRPVDRYYSKVCCCLVGILLISSANLFFFLEHNKHLNGTTSEGGAVSEGPSTHMIDHGKTKRWNRAMVEAKEMLAAHGEEAECLHPKVQESKKLLKQFQGNRRPSKPYLNMGFPKCGSSTLFDFFACLGYRATHFTNNSLAGDFEGICMRDAVANGLRPLETCARGVDAILQMDVEYPLGIDGYFHKPFRDECFFPQFSLLEELHQEAPASTFLLTFRPIHDWITSISGWGSTVMLNRFQLCDFPNLPRGIPTDLGNKTQVVGQMTEFWCSHVQHVRNFVKEYPSHTLIETSLYDNLQSAQIMYGLFPTKVDANNTSEPITTELSNGCWGHSNENRPKQWLRRRKGKQGRNWLQKEQQRQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV77</accession>
    <name>A0AAD2PV77_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042089759" description="Methyltransferase FkbM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="49022" checksum="E61A245105323B58" modified="2024-05-29" version="1">MKSVVVAFLAGFFSALCLAKIWGILAKSANDGSVTVNDDTLRKRCHNVTSLAKQTPPLPCPTLPSPILIPTLPDPPKRIAHPLGKEGFVWPSQKLGVAPREATERPSLQTPALSLPDFLESLRKSGLALHGFIVNVGAADSCLRQRFECDEANQLLPLRPDVALAKDEVRGRNQQLYTNTTFHGFLFEPGPLIREHRSVYVEGSYTVMSTPLSYSNAVASLEEAKVPKEFDAIKYDTDSADCDVLNIILEAGYRPRVILAEFNFVFPPPLLFNQMATPDGLFRWGVMEPHYQQVGDQCSLSHLSSVMARHGYTLVQVDWWDAFYVQNHLVSAATGGAPIYDDLSWYLHGYVANAPSNDDRLDFLKTTAYKAAASGVAEAWLQTIMEGSKAGKAEPLDAGQQVSMRTDFWWLGAKEGYVQVKDVKLVKQRNVCHDGCIPQPFTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXG1</accession>
    <name>A0AAD2PXG1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXG1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="969"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1074" mass="122447" checksum="93C6E195058A63F1" modified="2024-05-29" version="1">MASKSSLTYKRIRPTQQPYFRFFQSGNNKIQEESVTSRRLESLRYFHSSQDNTNGSLGPRQTFSTGTRWHSSNHRNRRGNNRRNNHRQEPSSSRAADRFQNHNRRDSKPSPATLLMDQWETSSSSSSGHQSSSYNANVQRKRFEERQVALCQAIVQYRNQWFEPDDSNIATEWKHAVQFQHPTGAAGPVTKQKLLETEELFGQICTLCHDFFVTTALLAESELTLSSTNDLDTKQKTQLQRQLQQQQDAIDILTTVLPFWETMRKDRAILVQQVLKQEPAPALTETNKELLLNDNPKGTGMKDRDDDKKSVPPPPEKQEEGGGKNWVAWIKSMVVGDGGSNDPSMVPVPSPSTPMAKKLEVSSLSAHDDVQFAPNHYHYNKLVGRLYFSYPPLVAFQAFQDEDDDLGQDLMDVVDEEDENDDDDDLDMDRRQTRKISKPQSLPDEDAKLVAILEQRASQIQRIFDQVPNTVPAGMGGSTVRSPVLTDKMVRLLIRAYQDTATLDAAYQTEQVYYRYPSHRRGLLWYVLMSYLQVTEKDPPPRSSSSGGENPDAMGFAQQLRKSPKKFSPKSASLATKRVCELLSKQVQQSNMNPNELHSCATIGFQCLANIAVPSLDRYYDRVHALATLKFGAKTWEALLSSKPNIETLQQQLRPKDSVSIQLLIQIFAKSDGAMMDAEDVRMEKAKDLLDNMWKCYSISELQDSIERSTFHSLLDALNKRRKRKKKAQDVTPFVRTKTGETVFDNHEDFDYALTLFDKMVTHEVWYPNEETFHHLYRLAEYGPQADEVSIRLELCRAILQEYPLSPYLASKHALRAWSDTAEKRHLVSEDKSPTNDTFGVDDETAAVAMERAFQIFQQLQMYSSPLLYQNAPQKISHVYNVNDVPTSLSYGLVWQTCYSVAQNASAATKKRAVEIATAMYRLAEQKEPRTELRPKSHRMFLQCLSLSTNDQERLEFAQDVFTKARQTNNSSGSGSGNRSSSSGSASMEPLLLEALLDCLVNPTTASTTQQQQQQQQQRQELIEQVYNEVVSAHDMPVMSDRFLTLLGRVHPELHKRHISDHHHQQQQQQQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXI0</accession>
    <name>A0AAD2PXI0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002286">
        <property type="protein sequence ID" value="CAJ1966431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXI0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37934" checksum="93478317C19AA268" modified="2024-05-29" version="1">MRKKARLKRLHISLYQAIVSKVKSQKKGEFQDDNVLSAEAGRKITERAHNLMFQQSGTEKKATYNVDEALVISRVMQQIRDEVYTRDGVSFIQQHYLNKGLKIFKERGKEAALKELDQLIKRSCWTPISIGELTESEKRKAVDAMMLLAEKNSGDIKGCFVYKGNETRDWLSQEDTASPTTSHEGICCTGVIDVHEGRCMMSMDIPNAFIQTLMPDLGDGEDRVIMKVTGLMVQYMINLDPTYRDYVVYENGKSVIYVVILCAIYGMLQALLLWYRNLRASLEEYGFVFNRYDPCIANRMVNGKQLTIRFHVDDILASHMEQQVLEDFSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXR1</accession>
    <name>A0AAD2PXR1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXR1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="369"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="461" mass="51617" checksum="B1457830D9583B69" modified="2024-05-29" version="1">MMMMTTPISELPVAPSKETLDALVHATARQLSVEESISAQEDIFGVARKQPDQERNDELPATLQMLEARLKSTKKGTAYEVAERIDSSYCTNHGFRLMFLRANKYNAKKAAHQMISFFDQKLNLFGRDKITKDITFDDLDEDDKKCLEQGSTQAVSTSKRHILTCFPGLRKFNTGTIANELRARYYIIMSLLQFKNAQIDGINVVNYAVGALKDQTSGTGFVALTRLLLSLPVHIAAAHHCCDDVAQYLLLSGALRLGSASNLARLMVHYGSHTEVAYKLGAYGIQQSSLPLNPVTHEVVLDNHHAWIRTRQVMDAVQSVPRDFSMARPSLVGSQGGFEMPSHLMPSQKKSGGVDTATPNKDIHPRRDDVLFGQENKGHPGNMKMHQLMDHLQKQYEAADKQGKMKISLVVVFSMKGTGSRFLDYDDATFQWQVVSDTVARNRVAKAIRNRRRYKAKQESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDB5</accession>
    <name>A0AAD2CDB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calmodulin-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDB5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1930705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31385" checksum="682262A2C73443F0" modified="2024-05-29" version="1">MEATSMIETEYNDEYDAYEAMMNRGAFLRKLRQMAEEDEAHRDVVVLPVLSSSKDVEITVDHDTLCYHSYLSVQAVYDDYKHVNYRQIDFGIVGDSPLVIAQDRTVGKGGFVWDSGYILAEHVARVTEWQTGSPSVVELGAGTGVTGLFVGRQVPQAQVHLTDLPQLLPLMEKNSSTSKNVTAGVLEWGRNVSGQEYDVILGADVVASIYDSYGLAKTIYDLSHERTKIYLACKDRLSGSIEDFEGQMKNMFEHVGRSKPNSSNNNPKVWIFEISGKRVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDL7</accession>
    <name>A0AAD2CDL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="13">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS2180</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="13"/>
    <dbReference type="EMBL" id="CAKOGP040000114">
        <property type="protein sequence ID" value="CAJ1930977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDL7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1930977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="457" mass="52745" checksum="0C00CF73D3AEA60B" modified="2024-05-29" version="1">MKITNPTGIDIFEVILFKVEFLPHLVTFLTLLWYFIPSSSNDISNISSDISNVTKGAKPARKWVTLKLFVLLYIPLCIVVMAATTFAVSWEDAYMRGYDIFSQPSLRPMLEAYIETGDGDLTDILESNKYAPTLGVYEIRYLFKDLLRHTLLHSNDHNEDNIDEGYNKGNDWFRYFLGETMMYTSGLYPTGKESLTEAQNYKIDYVADAIQVQPGDSVLDIGCGWSYLARRLAEEHGANVTGITLSKEQRQYFLDLDFQNKVTILLQDAMRLKERNDLPIGGFDKITSLEMAEHVGIRRYQEFLKHVHSLLKDDGVFYFQVAGLRRAWRFEDLVWGLFMGEHVFPGADASCPLGWVSTQVERAGFEIQRVHNMGTHYSRTIDHWLENWRSNQQEVEQKFGAAAYRRWEVFLAWSVRVARQGSSTLFMLTLTKAGQEARRIESQMNVVPKYVQYKPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFA0</accession>
    <name>A0AAD2CFA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000097">
        <property type="protein sequence ID" value="CAJ1929850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="307" mass="34700" checksum="C7579CFA686C93B9" modified="2024-05-29" version="1">MPTSTLESNPKEAQKDPPSPSLGLLKRSPPVPVEVTPKKKTKDQHEMTEYFGKVLNAKTVLRDFKEVTHAKNYMTKDPVNVSLCCIGYGVWYAIYLNGFDETKEAPYQQIKPVLTALGITDKSRQRDAREYAFALQSRILCAAPRRKSKDVDEPILKTQQKSGRMGEPECVFMCTMHDTTNDSKLAILNLVVNFLQARGVPAEISHHCDRTNPKKQSLDHFITDNSIIRLVKHQWGGRVDTRFYTAYPDSRHALFSEPYPKAAHIALGYPHIKKEVVSCPTTVLTDPIDLCDSTDEEIDDFADKHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGP9</accession>
    <name>A0AAD2CGP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38605" checksum="CC9E256E129DB991" modified="2024-05-29" version="1">MENTPEQQVEGQAIVTVLAAVLERLVNANSSLAKADPGQITKFHALKSPGIGILPYLERVYKYASCSNECFILALIYIDRLIQRNNFLLTELNVHRVVITATLLAAKFFDDAYYNNAYYSKVGGVMVSEMNGLEVDFLFRINFSLHVTPEVFEKYKAELVAHSANMGLSVPAPQIPPSIPEEPESSHQTYAVQQQQQQQIQPQHTVSATFQAGAAPNQIQNQSFVSNDTTMHNAATQEVLVPIGGQPSQNIVRSNTEQMIQNEFTQYLQRATSLPYPAPSEQQKYVEAVPTYHSAPMISSVGIDADQYLQLNKHLYPLETTLVHHHHGMETCHENGYAQGALVAGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGX2</accession>
    <name>A0AAD2CGX2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGX2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="205" mass="24050" checksum="4BE24EA9C05921F1" modified="2024-05-29" version="1">MPPYCFSASPTTMEYESKPDMSHLCSQPQQEQLQPRSVSFDEDEQQPAPVAPKKSVSFSPTSELYLIPHHNEMSEEERRATYMTSQDYNRMDRENVATVRQMQQQSFPANDDLYFRGLENALPQPMKERKQRIKFVVFHVLQEQHQSHTLNDEWIESLRYHFTSKSADFANKMGIWDYEAMREDLVNDAKFMSPIYGPPITTLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKF2</accession>
    <name>A0AAD2CKF2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="904" mass="101025" checksum="EDF278A9000EFE7C" modified="2024-05-29" version="1">MNEVKPVDANKNFSSSYSPSCQITTLRISGDNGNRMQKEEEEEEQKTMEDPVAVAVAVAVAVGESDSNSATAQAHVPEQPPAASASASFRHQPEPFWEDLEPFQPVTAKAYWRTSDLPSASTNSSSSSSSSSTPIKNHPPRAMWKRPLHPDPKAPENEWLPEMDVILQLTDIHMDSNDTYHYAKNGGPLHGIWATMTTTSSSSSSFLVDQYGNVPPANLILYPPGVPPPSNNDETIVVPRGKWSLPAGRKIEWPPLTDDAKLLVQTIFPEWQINQNSSWEPQTAKVFTKSRAASGSSQKYCTVGVWKFMNEKNNRISDSDLLPEILVEIRPLLSSFASKKYDQRQWEEASSGVWCTNPNSLANDDGQWQAEDIWFLPPHQTPPPGVLPRGKWTTIHQNESWPPLTEQAKRRRLGNLPQWPEVGKGEAVILPTTATVYSQLDPRRQDKAPNLQGTWKIVDSDSDSQSLFWDPQYVLVYPQQEQVLDATVPHGLWGVPMNATPNADGCWDAKNVWFLPPGTKNLDNFWCRGKWVYSPTKRNPTWPPPPSKHVFANLQTTENSKNVSEAASRNQKQRQEAPIQVPRKQDNNPSTRSIPGTERSTSSEDKVVPVPVTKKQDDDSSIDPAEPGFSRPNFLSPTKAAAAALRKKRAIEQRFSKHSNASSTTSAAFVKKPTLDRRYSSTSHKEMSEAIRKSREDRVRYSSNEILRLSENTKSMLEASSTLIASMVSSMPPSPIAESPSPVMANNRKESITVPKVHLVESLLAEEGTLVVLCKEIPETRTMGLDQDNALLLCYDVPKYSILYVENDLSLAQELLEISRKSIYPQFFYEPNVDSDSDSDNESGGGGADTKNKETETEKYVYLGGLATVRAMLIERMSFQYRIREQRERRKSSSRPIRAQSLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKT0</accession>
    <name>A0AAD2CKT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000657">
        <property type="protein sequence ID" value="CAJ1937524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02393">
        <property type="entry name" value="KH-I_PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="211"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="280"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="351"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="419"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="498"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1937524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="601" mass="63544" checksum="79F38F56E90F7EB6" modified="2024-05-29" version="1">MDALMEQSSILLVVAGVAVALIAQSLFSTPAKQLDDTPTTSQAKSSTQANAAKKKKKKAKKKAAPKKAPEPEPEPEPEPEPEPEQAPAPAPSKKKKKKKKKAAAPPAPAAEPALEPVPEPASEPVKEEPAPTVTDEDDEEDDDEDVARLLNSTQLSKAQKKKKKKKKKKAAAAEAESKNEQDEGSWVVVNKHHSSNNSTSNTAASTNDADAKRTEIIQFDANDKPVLVGPKGATIQNITTTSGARLDIDLPVLKITGTEAAIATAKEMVDKLLSSHKAKSAYSITLSGKDIKSSEGIKAIIGKGGSNIKQIQATTGCKLDANIDEGKVVITGSSEEQIQEAATLCRHTVFGEHQVAMDLKNKGNVMVVMGQGYKKIREFQDASGGAKLDFVKNTTTLQISGPTAAVNKARDMVTAWLNHCAGITLNIPQSAPGSFDKVGAIYGKGGVTIRTIQDKTGAFINVDDKEGKVQISGAPAAVQQGLKMVQQAMEDGCLMEEGEIKDSIIIPKNAGPAVIGRGGSAIKQLEKTHSVKVRVSGQTCIMIGDPAAVARCKTEVTETIQPFIEEERIAQEAERLAAEQEASAGGGPWSANLQDDVADGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLH1</accession>
    <name>A0AAD2CLH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CYCCA115_LOCUS3511</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040000313">
        <property type="protein sequence ID" value="CAJ1933902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000150">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="19">
        <location>
            <begin position="143"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAJ1933902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="463" mass="51506" checksum="58554F69C7D9A41E" modified="2024-05-29" version="1">MERRKNRRKNGDEEDASSVDSIRIIRSPSSPMSPEKKGKAYGGSNFFLASKGAMLLVVGIMIGYVAVPMALVELNVKDIHNRSSYGNDGAPRMRSLQSDEDSIQTRVAEDQKLLSTQSLPTITSPQIMHTPILSDHRRKKIVVTGGAGFVGSHLVDKLMMEGHEVTVLDNFFTGQKKNIAHWLQHPNFSLVVHDVTEPIQLEVQEIYHLACPASPPHYQFNPVKTIKTSTMGTLNMLGLAKRVGAKILLTSTSEIYGDPQVHPQKEDYWGNVNTVGPRSCYDEGKRVAETMMYSYKNQNHVDIRVARIFNTFGPRMHPNDGRVVSNFIIQSLQNKPITIYGEGEQTRSFQFVDDLVNGLHALMNGPYDGPVNLGNPDEYLVRDFAVLIKKLTNSASEIQKLEQTKDDPSRRKPDISLAKEKLGWSPKVKVEDGLQKTIAYFQGVLDQAGEIIPTGPGASKPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ80</accession>
    <name>A0AAD2CQ80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS7983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ80"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46157">
        <property type="entry name" value="K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46157:SF4">
        <property type="entry name" value="K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042012965" description="Cation/H+ exchanger transmembrane domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="91"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1942510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="475" mass="49367" checksum="F299F79D65C78E1B" modified="2024-05-29" version="1">MKTVFKSSLLLAALLAGSEARSAPFGIKNQVASLKENSLPNVAADVNKHSSWETVPRGGADVVSIASDAISGLKKYMGGAKADTLLLLLTTALNTPICQALKTSPILGFLALGVLFGPNGYSLISDVHKTEMMADIGIVFFLFEMGIHLDFKTLMNMRKDVFGLGGSQFMVTAIAVAVVAKLCGLSTAAQVVLGGGLALSSSAFVLQLLKDKNQLETTFGKKSFGVLLLQDLAVVPLLVVTPILAGSGSGLGEALASAGLKAAMALSTIGIAGKFLLKPFFKAVAGTKSQEAFVGAILFTVLGMSFLTEGLGLSNTLGAFLAGVLLSETPHRHAIEKEISVFRGILVGLFFFTVGFEIDLQLIANKAPLVAGIVAGIVALKAVIASGVAMAFGLDKSIAQQVGLILAQGGEFAFVAFRLARSHGIFDGELTKLLLTCVSLTMGVTPFLEELGTKMAAKMAPVPAKNTVSFGKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQB4</accession>
    <name>A0AAD2CQB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQB4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="552" mass="61280" checksum="9F03DE582645B3BC" modified="2024-05-29" version="1">MPDKGQWKSAEDPKSGKTYYYHTVTRETQWRKPLELASDEEKRKMAEKEAKQMDFFAAMEANILNSLSQGVLPGSGTENEVQRLASRKPSHREGRPALERTISAMDESVLKDLIRRQPSIHQTKKVESIQSTVSSLGGFESIIRQPSRLASVNEMFNDLPDEESNNSEDNADFDGNASNRSDGGALNASTSGFGLSWGETAALKKLGAIAKEMKDAGDEKAPNKTHDIKVEGKDTSKISASPVLTNGTRRTKSEGVFQKAKNIGGRDLDFDPSDSDDDDDGDDADRPTVRRHNTCGTMYLKTTMSAPDVDATIKCVCGVFRTHILTSELVDPETINEYEIFNDLRGGSSSGNTAPPSLDVVTTFYRDIFLKAQMESDCIIMSLIYVEKLIKRTRGALRPRASNWRSLIFSCMILSSKVWDDLSMWNVDFSQSCPKGVSFPLQRINDLEINILKALGFQVKVPASEYAKYYFLLRSMIIKSGLGGDEMTNVLDVEGARRLQHMSSQFESLSTNSARTSFEAGNRAQSLNPNILGKNTKERKSVKMGLEHIVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQJ1</accession>
    <name>A0AAD2CQJ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAD50-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQJ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="82625" checksum="FA612FF99683FCF8" modified="2024-05-29" version="1">MADLDLGIDFSLESLEKELQSLESSLEDLEKKKHALDREVDGSQFISPDEEEKTVEPEKPLAVRWNELAMEVDSLVLAQDVCEWIRNFSEKAKKQGGMDILLESEMCTTLADLILKYPNILEMAPQVYGDHYLVLYDYCYDSLILLLRGELSTHRYPKDCRKLIKMAKKPNSSILAICKQLSWLEQSHHSVLRAIEGRTQPPSPPIVLTELFAPLVQKVRFHFVDGSKERITSTRVDRLPEWLLTYLRENVLQEKGPFFLAMILLQEAAGDEGALLFLNELVRLVQWVFSKRNFFRDPGVAGPQSNPMLLYSAMEHLIRFDKALQQCLPPTGSDSPETLLGCMDLLVTSDEDLMDWWIQREKESMFSTLMDQDSTDSIPKPLPNFISPRAEVFCALIRSTQYKASVLNAPRKYLREVAVPLCSQFVDALHERINSLKRRLFNYSNKRRIVSGLAPRDELKASIFEWIEVINGARLAADLLGRQDSWQQEESVAASQSDHDLARFGRSLERLNEVMIDEFLVSFVETILLEHAKCASYIMMAQHLLATQEWEEDGSDLSVELRETKLALEILRTGCNEVVNATDDATGASQAPSPFAFAPVVMQEQVMERLAHKFMEVAMDVHSMTPEIWQTGARVFARDVHVLFFGAPFPLCQRLLDVAILMTVDSKVAHSLFLALVGLTGARRLSMDDFINDERLFDEAVSMIRAKGFNRLELSDVISVLGRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQJ3</accession>
    <name>A0AAD2CQJ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000957">
        <property type="protein sequence ID" value="CAJ1940775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQJ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="192" mass="21040" checksum="AEA7B7E6EA0D6C37" modified="2024-05-29" version="1">MKRSRLISLGDDQLIEAEKRQKLSSTSMSNDDGSKKNTPRGGSKSYDGRLNLLSLVCNQQLSNNKNGKPRQGYAAKMPHKIPTYKTRNKTDAAAFAKSAERVLGIVAPAIISPSEDDSPDQHVRLADSEVPKKNVTNATFQTGQEGGKTKKQPFVWKGICRPVPLPPRLPMVPAGYIFPLARSPDSIRCIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRD1</accession>
    <name>A0AAD2CRD1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001114">
        <property type="protein sequence ID" value="CAJ1943690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRD1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="165" mass="18767" checksum="4A9ABD77B7966DC0" modified="2024-05-29" version="1">MVIQLEDCIDVSQALHGNDYDYDYLFMFDHSNGHDKQRPDGLNANAMNKGFGGSQPSMRDVAIESEDQLGTYNPPGKLKVGETQHMNFDQPGDDGSCWMNAEEKAASKEDAECRNPESTDEQEMIRYSFKKTELVERHRARPSMAPKRTFKRDPQTTKLQSLKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSZ6</accession>
    <name>A0AAD2CSZ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001160">
        <property type="protein sequence ID" value="CAJ1943920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSZ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="308" mass="34206" checksum="CAB1E157B97ADD7C" modified="2024-05-29" version="1">MIDLHALKGEMIQIFAGKYAGHEAWMDNSQTWHVNKGTDTAPVIVRLRKGKGLVQSTIWKSSFQGFDPNASPHNYTKAVLCQRPGIKKNLVCVTRQMAQCIGARQKQGKMVKVMAEHLEDAFKLQESCGADAICRNIQYPDPNEKEISSMISGMEQEVKAAIEERGAILNAMETNSNKRSASGKTGNNEKIWMDNSQTWHVNKGTDTAPVIVRLRKGKGLVQSTIWKSAFQGFDPNASPHNYTKAVLCQRPGIKKNLVCVTRQMAQCIGARQKQGKMVKVMAEHLEDAFKLQESCGADAICRNIQYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT27</accession>
    <name>A0AAD2CT27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001358">
        <property type="protein sequence ID" value="CAJ1945328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="645" mass="73055" checksum="70D8F86740945E97" modified="2024-05-29" version="1">MAQKEETRWRRKAQGKGFSGGLQQIKVAQVAQDGSSHWVTCQSKRLLEEGCMQENCLWYDQTRYPYPTPPTTEPLYSNFNGPNAEQNSKALLQGLYEVETLDRYLASFIDHCQRPEGLEDQPLEVDLEDHVSFWRQHGSCKRHQAIDLALTKRLTWDLLHLQRRPVGWISNDAKSCFDRIVHGVATTSLMRFGIQCCTLCSMFDTLMKSKHRVRTGFGDLDRVFTPPTLIPFQGCGQGNGAGPPIWVAISSILLGMMISKGFGFDFLIPVLVYDAAPDIDKLPHPAAPMLHRVMKNGAPVVVHSEPWSQSQLDMRVAWGCHSSANEFKEFLMEKFLDFGRKGFLILLPYDAIKDEKGLCLSPIGCVPQDNRRPRMIVDYLFWGLNDETMKLAPEGAMQFSTAPLCIREALMKANPDYGPVYMYKNNMLDGFYRIQLDGGLGVNHIGQWLGVSHRVGPMMTYWVLPKSGIPISVDTVQMVTKAEQQTDSVNQQMQRWAADVSKIVDAKSTYINWGKEEIPHQMMFDFDNKDDKFMRNFDMLINPEMLHDGDFEGTEQAADDLDAQDFTNMKIGLQQGTEGELQRAKVKQQIVDENGRPIGVASSNQLLDRRQYEVEYADGGTEIFAANILLRICLHRSTNTDISTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT64</accession>
    <name>A0AAD2CT64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS4669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000449">
        <property type="protein sequence ID" value="CAJ1935334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="318"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1935334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="56864" checksum="8D79802DB967D17E" modified="2024-05-29" version="1">MTENQRLQTFAALCAGQSDAPTDKARDASSAGAQNGDSKNSIASALSSSASSSTAQQSQPAQDAGRTSHPAVQNGQQLQNMRGQELQQALARAALHGGTVSPSLAAAQSLFMQGGLSTQHINDAAVTQMALQQYLQQAQQALSNQQASQTLSTNGGGSLRESHALMMAALTGGKTNPFGHVTGTDLLHGSQQKVIPSASPSNLEAPTEVANAIAGAGNVGSSSVPTSMKPPPPPSQKSVEATLSTAGIPSILGQTPPKIAPMPGAKPIAINEGGSESSVPSGFDDKKQQKRAANRRSAQLSRKRKKQYIEELKEENDELRRKEQILRSIPDLIVVFDSSGKLGFVSPSVSRFIGMSPDELVGTSFWDRLCESSVRLLKSAFMDALAAKKSDSDTCPLGSGVWDLRLVDKESNYTLVSLNGVVHFSGEAPECVCCIRPLEQQQPVQKMTNEVKKQPTARPVSSCDGSRSSNSSRQDALEIRANPNQSVISSDTTSADDSGMNSARRKKPRRREVGRGAEGESVRISDGDSVSGSDDGIVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV55</accession>
    <name>A0AAD2CV55_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV55"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF958">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WNK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="382" mass="43610" checksum="9E61FC9C23316E56" modified="2024-05-29" version="1">MMSSEDERSFDEDYDDAPTAIPILLGSEIRIGTLLGRGTFCKVSLVKDIHLKAQTEPGLVQESRQKLELKFKIAASQDSYQQQQLDVFGRQPNAQNPVNPKPRMALKQLKNLSEKSKKQAKDDLRRECDILRAIKEDWCSHPNIIELHAIGVESSKEFHDRDIRPSFLVLSKLRCTMVSFMTKWREQRGLGVMEFFGINIKESQDMWLERLMVLSQIADAIRFLHLHNVIFRDIKPQNIGFDGDNVPKLFDFGLAKRVYSVEENYKLTGNTGTLRYMAPEVALDQPYGMDVDIYSLAILMHEVLSLKIPFVEVPASEFRHEVIAKGKRPPLDYGWPSPLSGLMASMWHESPSKRPPSSEVCKMLTLMLRGSDAGLFPDRIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CW12</accession>
    <name>A0AAD2CW12_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS9358</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CW12"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744:SF2">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="113"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1945214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="510" mass="55910" checksum="6E90837DB7C5585E" modified="2024-05-29" version="1">MEGGNRPKNVNKETSNTETETTMMMPSSSNLPFTPKGESYGADINVQFHNAATSTVSGKSAPPRKPLHQEVKPESWVVPTSTKAIRAVNPVTFAFSRLADKVKLGSQRTDGKNPISLANGDPRSASDFGPCTEAMKASVHSMIRDAQQSLGYANACGVSSVRKAIAEHHSYPEHRIEARNVIVTNGCSGALELAFNALLDPGCGVLIPQPSIPMYEMMAESVGATVVKYKLQMDCNWECDLEFLHTAMQHCGNKIRAIVVNNPSSATGAVFSQLHIVQLLEFARIYRLPIIADEVFGDMTYAPSQFFPIAQVAAQLGRQVPVITANGLSKQLMIPGWRAGWVTFHDNVHGSLRELQAGAVRLAELGPGVSTLTQCAIPQLLSKSNEGLNGWKSRLQTSLERQIVFLMTKLSMCDGLVPMAPQGTYYTMVKIKYSVLGMDDWEFASRLLDEENLIVLPGSALGAPNNAFRISFHLPQRSLYEATTRLYNFCQRHASERREAMDTLVEFAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D0V6</accession>
    <name>A0AAD2D0V6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D0V6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="187" mass="21686" checksum="14F4DA538D0A4599" modified="2024-05-29" version="1">MRTTRKSKRRSNTTKKVSFSSNVLVCEDDSFSQAERNQMHYTREDFSSFTGAVLQYIDSVRRIEHQSSQPYSSTLLSTGLEGFLHPEHKMKHRLQGVLAVLMEQDRQYMEQGLFTPVDFDSMSHVYHIACQESQQEAHQRALLTEQKLKSEAFFAPKSQVYNFTPQESQEEVNQRSLVQRRVVSMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBC2</accession>
    <name>A0AAD2FBC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1919311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF2">
        <property type="entry name" value="SLC26A_SULP TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="515"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1919311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="892" mass="97877" checksum="2759DEA39EC581AE" modified="2024-05-29" version="1">MANYDEVNKLRPGDPESLSYGATSSVRFEEEGSPEEKRLLNKINLSRGKTNHKGVQHYAYCVVYALVNVIIGAPALYGYAAVIFNNPIFDGHMNALSKLVIFSSLMHQLGFTLFSNLEYAIGMVQDAGLIFLSHMANTIADRMVDDGHSEEEILSTTLVLLCLGTAALGVVLILMGKFRLADAVAYLPMPVVGGYLAFIGYFCLQAGVALCISTPMMNLLDWGHIFDKGNFVLAVPGLLAGLVLTMTSRLAKSSGALPMVMIVIPALFYLITFLLGFSLDDLRSAGWVGAHAPSVPVSDLFRLVDFGMVRWDLVPEILPTWVGMVFVVSFSSCLDVAAIGIDRGEALDTNKELATVGICNLMSGVTFGFTGSYIFSQTIFTYRTGVHDRTIGVLIMVAFLYIVVSPVNVLEISPLFFLGSTLIFIGYDLMLEWLWEVRHQVFLTEYLIVCFTFCAIQVVGINFGVVVGVLVAIVEHIFSTAHNTVVNRVEKRSNAVWSPSDLKILNDGAYSGGSPRIVTLEVIGPVFFGSALHLLNLITDEIGLDQSDGDFAGSMSPGTPHSSSVILTKNQSFYMKSGKKPHIRPPSYLVLDLAGMTNLDASAARGCFLQLAKMCAKKRIMVCAAGASNKTEWMLRSHDVSLVDVEDEQLVKERLLDPELRKGAKSSLEKILLFLTAQEALEFCETPIVQSSNKSKRSLSSSKLVGSEEQSISFVLAYILGSSNEEAKVLGRLEDKRFHEKIVLKSNEKVFYKNTYPDAFYVVLSGCVARQTTSLIPPDPRSKLVLTGAGRVEQKNMNSAIDLFDDKFIAEQKDALKKGVVAVWRIGGIFGYLDYLMERQRVFQAAATQEGTMIAKVTRSHMDVLKSEDPELHALVQKALLYACTMDLAYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCJ6</accession>
    <name>A0AAD2FCJ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCJ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1924110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40179" checksum="F4A27F1A8DE5FE42" modified="2024-05-29" version="1">MKSKTLLILTLKEHEDGIWIRRLVQSLQATAKDHQVFLSSETDTDTPNTIVQESPSQQIFIRVQPVEEWLAQGWVVSLSPSFFENVMGIINRVSDAASPALFKATCAILGAAQLHQIPIVNGPITYSLCGNKWCHHILFQQARLESPKTMAYWNEEGDKANDSVGPKMEALAANGMQHGKIETDLLIKPNSGGFGAGIQRVKVPLEEPLPVFEDCITLVQDYHPPKDNQLYRIWFLLGKVQCAVVRSITDSDNEFINACSGACSIQKPPSAWLVSENVRTEVEDQLLPLLADAHCGSIEFLYTQDESNKRLYFDLNLLSTLPTRVSNTGGVWADDYDPWMELANAIWKVVAEKEENRANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE04</accession>
    <name>A0AAD2FE04_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000158">
        <property type="protein sequence ID" value="CAJ1931516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE04"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1169" mass="126466" checksum="CAF56D8EB1E6AA56" modified="2024-05-29" version="1">MGPALDVLNRSLHGDAGARSFLDQTSSIYVLDATDVSSPKTYGCWNFINEAINEVERAEASAQTVTLSAHVQLLIQMALRVARRSSDVDRYLMTMCIENASRYHGSPNESKRLIEINGEIRDIVMGRIAALALDPNSQNPGNTSTFADGTVLDMLCGVLAANAVSNGPAAVHHLISEWILPSAITFPPYCLACVILHLALEASRKTAPAGIQDMLQQVSSAVISRVLAPVLADSIKETNANSQTNGEGEGSTHERNCRIAALCLQAMDVWCKVTDLSLAQIRHVCSKVQINIVDVLSDAMYSDSKLVIDALAELIEGVVNKHQDLTVSNEHMSQVRYIMQVDEASFRSHITKEQLITIESKEMLSILEELNSAIGLQRFRFIDRQNSGDESVCRNLARIGSSIASACIKGSPGNSSAAGSLSMGRGLHTLLIQAASHPSVNVCGLAIDVLQQFLPTESGLDIQLLPILQRRAITPYHVTNGVLSLEASDICSVDYIEFENFRSTVLTEALAACLKHDGKQFLASCTNAVDEFCAASPSVHASFHLEAALFCIATVHGEVAASNLATPIVAASIQTCIHALARKPRTLMANSLTLVQANNLIYNYAPLLVTLQATEALSAATDFALSTFNLCGTSFPDEESSVSMRQEGDVSPYSKACFSLKKILTLVPHNFVAGQAVAAFGAAWELSYSAANRMEILTVDARKAMAEGICYVIACLPENQRGNSLLALAMPSIDCLETMLQHAKSAANSSLEQQERILQRIADEMIIVTTVKSSFSQALANVEQPSTASIRAIELPIIQRLWPSVSQAARQYNSNESVSEALGVFFASCVPRVLNTSTSFEIFQQLCTEASAIVQSGTSKNHNLECVLKLVESFANAHGTVMDRIAASLSQGPHQQHQGANGEQGVEREQEVYRCIESLILSSIDALKPMLGETWTCERQGNGQAAFESKPVAKNSSQEKATTKALPSVFSLLKSLSRSCPIFLLHLPSCQGEDPREDPLFARAINAAVASVLDSEDLLSLGSLEILARLIQLAESEIEAIRNVAGDILSRVRFDVTMSLVIGCCGKLNASTLDHASELLKRLLMLNATPTEELRSVLVRALSNECVHLGVRGKEVVLESLMQSCQNIVSLEDFSRLAHELWSLHQIDTPEALPNSDKVARFCRSYSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGJ2</accession>
    <name>A0AAD2FGJ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="294" mass="31948" checksum="E2235B4E48376371" modified="2024-05-29" version="1">MLDTFAETSKLIIKQKFEPLEALANAAANALDMDALGGLGETANKYDVFTDDGGDKFRVIETSEYCGCCTGRACCRPNHKLQLHVYEPAKSDTTEAMVMDRPCKCGQCCAIFDICRQEMTIFEGPEINGNKMGYIKQPILGGFLSPTLEIMDREEDDEPYATIKANAVCCIGGLCCDHTFEVTDKGGTVVGKIVKTKPSDLGQFAKELASDADVFALELNQNSHLTAQQKANIFAGLHLIDYMFFENEGELKLDAVNQECEIKCCDMYCCGCLVPCKCSCGGSSDEDGEGGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGK7</accession>
    <name>A0AAD2FGK7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000102">
        <property type="protein sequence ID" value="CAJ1929983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="990" mass="111335" checksum="AF5118A8B9D5CAE6" modified="2024-05-29" version="1">MDCGDGSSQATKVGPNKPPQTSQKRSQEDVSRLNRNGNTAKKKKHEGVVIDLCQDYNVPELQQQLFQAAPTEELVSSLIGSTGLSFSRESKNYSRSVAVYIFFFSRNLGVKPYELFNNKLMGYFLKKGVSRNFGVFLDPIYKGNLEEHILKMKQYNIALVEERMRVVENVLPKSPGPQQKSIVTLTRDAWDMLIVSSTISHCLRYALECINPKTCISFATTFRQAVEMTEDCLTMEQYRERAINLLLALSSAVGPHRSLDKQISAVLQDPKSTPRQLAQLVDQQGQNKNPEQAERLASHFKVLLLAISKFKPNVTTRNLSKKTLCHDGGKTKGDYFNIWLPTLAVGFYSLVIFPRDTKAVNKLKEDLNLCLGGAQRLQPRKPSKKPPAKPSQRTRVGPLPTQSPITQNNSPAEPPPPPAAAPPADHDDDQSNSLDDGGSCTTSSSSDSNPCSNKSSTIDKDGQWEPKPFEIEYCVPTPTQWKRYQEEGAMSCWLHVETLYTNIELHLAMNEIYCGAKFCHNKHGCRILSGNDKSTVGVDKMKGLFIIPKETPLVINSEIQVVRPNSNIWKKMPEVNLSLLINTAIFLHQLKGKAYNYKRSEHAIQIPFGLVNPCRQWSGFPLLQRCKELNDWQKDIFLTHLGMICDNISIHIDEFQRLAGKQPLCQNEDRDKRYAARFRQKLKLAPHSRMRKETAFLTFSPIGPNHFPHNKDHCDTSNPVEDGYHETGCHSQVVTTNGVDMYLFQVIIASRKWISRDCVMNEHSYDPLSDADGAEEGGDADEAHRGDDDKQESIDDDEETENGYEERSHDDDDDDDDDDDDDDDDDDDDESEIGDASKEDEATFLNIGEELLIGFVDKGPGGQLELKPLRNLKIGMVMYVCPYIPVDLLAPLVQYYKSDTYMEKFKNCTGIVNHSSGKGSASPPHAEYLMSGPSNWHEHESNLMHAIQKALELETGHGFSYNDCGCIRTVNGMYHQPSHVDHGKALQLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHW8</accession>
    <name>A0AAD2FHW8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="435" mass="47577" checksum="426386F001DD6E23" modified="2024-05-29" version="1">MECRAPLTSAVLPPQMPLLVDPPGTGSRQYPSTPPRPTSLPRASLGGGSASRRYQESRGHSRSPYQPQKPLQPVQRVDLPIPRNHVLMCLIEAVHAESREDEGYQSGDDDELVLRGIKVMGSSSGTYIVREPAGLKVYPSNSPIYPSGPEENSVMTLQHGQMVQILLFENRIATVARGGGYILVDNSSQLVKIAEVTDPACKYQATNKVLLTQIDELEAKVQSLRKHQRDVARKLDVLLEDTANSSPFGPVPEVLPVYEMEEEDGGVGDDRRDDSGGSLARKTAYADPNDSTLTESHSFDHPRSALHPKIGGTSSFGEESAREPKTKEITPRRRDRSKSQDQATWSSFWPSIFGSSGSPSSIRPHMEPQNSDAPIGIGQMITNHVAPPSPSRNHHSRVDFSGLSGHSGLGKTSKSKNQGRRNVRMLSHHSGARFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ14</accession>
    <name>A0AAD2FJ14_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000411">
        <property type="protein sequence ID" value="CAJ1934893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="395" mass="44460" checksum="AB65ADD6EFEDD4DC" modified="2024-05-29" version="1">MFISATFSLQNVSCFHSLFFQNYTSHSPPGDEFRRVNALIQHQNNSSWCPGAIDRHNGRRQQRQQLNQNPINPSEYVCQQVYNPPVLPSEIEFQSDEPKSSLQEAPHTREKRKWSSSLAAAACRSSKRRRSVRSPVPVPEPPPPIAARDVDDVNFDPELTDFAGEMERLKLGQPFPPNLLIECNSTCPPLENSSLAVHAPLPLPNASNRKDYPRTTTTTIMGCKLNSEIGKVYNFPMEEQQRQFSNQFLPADKVLAKIHFECYQAGSPLYLPDRIIGILQEANWTYAGFHLGSPYITKRESLLKRIEKTVGATHRIYCVDLGAHLQGNAFTRKGNLKGNLTSCTSFDIIWTAIDDWPGLFLESPSFLKVMSQTSPDYGPSISTTDSPFLNSRCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ97</accession>
    <name>A0AAD2FJ97_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001125">
        <property type="protein sequence ID" value="CAJ1943740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ97"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="130" mass="13994" checksum="F07CE171657B0A06" modified="2024-05-29" version="1">MSSPEPSQESVGCFVEELANPSDPPTNVRTTSSTEYFKSQGFTISSSTSWSKNSSMSSTGTNTNNVPQRKANILETSVLQQNVDEANSQSRSPTQGDLTLCGLATGVVDCGLRHKLPCVIFGDAYPWWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJA7</accession>
    <name>A0AAD2FJA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="26551" checksum="106B8AEB1B163E92" modified="2024-05-29" version="1">MGAKPSTMKRTQSAAFGRLRIDSPRIVTPGSVKQSLTRRRELRAQQVGTGPAALIRPGSQSGLAETSPLLIQPHQQQVGRELGATENQFMATPESPALMVWIVPALCCAMAYALYNIFIKKGSSHINPVLGGVILQLVAALLGGCLLTFLILQETHKGGDVGNIVAFDKEGIFWAVLAGLAVGTAEIVSFLVSSMGVQAMQSIPVIIGGSVLFGTVIGALALHEDLSMRGWGGVVLISIGISLVGLDSEGEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJH4</accession>
    <name>A0AAD2FJH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS9305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="656"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="864"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="870"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="922"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1945161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1158" mass="125136" checksum="D84DA991878C6D80" modified="2024-05-29" version="1">MSTNSSDESPRQIEKGEETELKRPPSNNREVNIKTGAGSLTDENVGQGSTPPERREQLQRSSSRSPNGKHSSSRHLSSRRSSHDKDRTRPSERKSTKSSGDKHSSSRHLSSSSSNDKQNRSERISKDGSYDRRRDSRRSSNRSSRRKHMSERELSTPQHKRKSSLEGEPGVPYYDRQYDSKRKSSRHLSEKNSSERELRRSPHKWSSERELSRSHRRSSESNQRLSSRRFDTKSCTKPTSDHVERDIHERRRSKGSSPHPRSQRDGDDPYHHSIASPPFSTGQDLRSAILLYETDDTDAKAKEKSRRGGSERVVTPGIEHTSSNSSAAVSMLYGDNTDTDAKAKDKLRRGGSERVLNPGIEHISSNSRAAVSTLYGDDKDAAAKAKAKASRSGGAAMFSPSAGTNSSTKSIATINTLYGQDEDFKAKAKASRGSSELASIPGVESIALNSTHTSVSTLYGNEADSKAKTRAASGGSEIASNPGVESVNYDESVASTVDTLYGNDDDVKAKARASRGTPKFASSRGMGNAATGMPSLTESIPAESVSSSENDVEEPVARRVSIGSTESGRSRNSNPEREIDCGANGVPSAAMGALQIPNDPNAARVQDPDKKKGAEEEKEKSKKKPFLLFFSLLFLIGGGAAIWYFLFRNGDTSNENPQINPSNIQDPSSAPSPPGLATVTPVVPLASSSPSMFPSSLPTKGMLYERLNESDCEAIARNQTISGREQKENANFGLDLEVVLSDNATMTEPLVEQLLDAIQEKILPSLAGCSIIVDRFLEDWRFVIFDAFVKGSVQPEETCYDAELQGQNCHRVYAELALFLKGKVRFLDIIRLISDEKDNFSNDLGLSDQFLFVNLFRAEGLTPTVPPTMLPSNTPSLTPSQAPTGKPTPTPTSVASKAPTIFPTGEGSRSPTLVPSLEPSLMPSTGSPSWNPSLQPTEVPTESPSAEPSSVFSRSPTLLPTRDPSGRPTMNPSTAPTARPSKPPTMAPSPQPSAVPTSVPSAPPTASLVPSVKPSSIPSLIPSLEPSRLPSSAPSSQPSVATFFWAPCGRVGRCSPASSVQNSNYIRFNGTPAGRQIGIRCCSDIALPRFRQNGATCPYADSEIDGVCYDSVTWFEAVTLCSSIGARLCTKTELEDNCTRGTGCNHDNRYSWSSTPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKB2</accession>
    <name>A0AAD2FKB2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000598">
        <property type="protein sequence ID" value="CAJ1937070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKB2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="252" mass="28484" checksum="E5B906D8130B6607" modified="2024-05-29" version="1">MYFENPNISNSSSHQGSTDRIWREDKPVGESCQSGHGPHFHSISKEKTKTAVTKPALSFVTFGSFAAMEQAHQLNFLVNDMLAFLNFPIRLNESNTANLKGLYDTGGCCNMGKKDYHLSIAKQHPHLVKQIFDLQKIRYAPIKIGGIKDSVEIDVIIKYFIPFENGQGENHTLMIGLTDDLPINTLCGLPFILKAKLVAQFYRNAVISNFFNQEFDLTLECPRLLPTEHVERNQSSDRKVFSVRFDTTAENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKS0</accession>
    <name>A0AAD2FKS0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1544"/>
            <end position="1556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1594" mass="177439" checksum="488752FAFB5B6F98" modified="2024-05-29" version="1">MDGSVQNNRMEYASLADADKNGTLRQRVKVPENIVHADLESDENMEKSNMKQNRGDTNDEYAADENDIRTLPRNTFSFLIIARYPFCEKARPDNNDDRTSIVQNRRKKKHRDYLCIPFWISLGILVLQITIYTLALLNATDFGDDNPFNFPIDVDPSTRAAELFAVMITVYTENNLFQGVDLFVQSFDTLVETPGVTFYKYYMTATAAVLVGLYGIFVTFIIIMQAESVVDLLLDFTAMEFVAALDDASYVLSIGGFLGSHMKLTARVVKDSKYASKDKRKWLRKWPLFVLFAAVMTCYVIVRVNQGNRTYGDNEIYVQFHDEVHPWLSTLSGVYIGCNLPSSDHASIIRGKDHDLGRTMYTKLSVAECERNWKAEHGAFFYCDEKHWVFAVGENKMDPCNKWIMQSIKPKPSNTDEYDILSHSTEVWLAKDPERTFGTGVVEQIQFLAGFQSSQNAGRNCSVLASTGNVFSYPFYARLEESQQEKSFASERPVYFAGDDTDGEYIFHTGRRWVVVKANQIPSCVRNCNTAENCCKLDPYSGNYTVSFISDPMDLRTLGDTWIPTAELIWYKATGDTGNSSKPIVERQSLVDQIDVIEALSSVGSFPNREEEERLIDLHLQSARLSCLCDSGDLECEKNVACGADETTVWIDLQTDSRPQDTYFIVMGNETWGTIQEEAATSYDFSSVRQLASSENFGITPLNDTGYFDWQDVRETGFAAKANYQFTTCLPKNKCGIIYAEDTAGNGITFPGRFNVFLNTRKVERDRGGRKCVYDLCQESATCSDSSLRKELFNPEISCTDESVPLAFQFFKDTSFSLSNTSQWLSNAEGEELYGSGPVEWGSLFFDAQRQIWNNFDFVDFDAEIIFSPIRTATCLPKSSCAIVAFDILDVPFESLTSEDTGFPFEFPSIVYNGIALEPDEVDPTFNHCVYQFGDPCATEVICSDTAIPRPYTTESNCAEGQKALAIEVVTDMFGAETSLVMTDLDTWRNGQLTGFTPLLETGTFDWGFLRWNAPFVEESVSYTFDSCVPDDQCWVVLLGDAFRDGIVNGGMTLVYDNADILFGPLGDAFTTCVFQFGDCEAKLDCYDIENPLPPYNPEIECQSGKPLAFELRADCCSSGDNAIVVTDSDSWNQGLASTFPFVDAQGFFNWGSFNIFAFENNVSNRFQTCVPDEVCAIVAINDSFGDGFVGLGGLTVVYDNTETMLGPQVDDQFTDCVFQIGACETQFFCENSNTPLPTSPPSPPTTRPPAFNPDINCPGGKSLAFEFYSDTTVAVHTITVADFYSWRRGILSNAASPNDFGYFEWDSVEISNFESGTIYQYSTCVPDTVCGIVALEDNFGDGFDSNDWFTVYYDREEILAAFATESFRTCQYQFGSSCGQQGSCTASLPPPYNPEMECFNGTSLALDFHSDFFPSDNDLLVTDWDSWVQDTWANSSSSILNQTGFFEWGTVQISGFDPSSSHHFRTCVPSEVCGVVVLRDSIGDGIFSDEGLRVVFDEEEIPMFWNPGGRFSFCEFQFGSCGQGAYCTSDPTLAPSPFEPNGDDGAVQDDGIVGDGVVPQDDGVAEGDDAARVVDDDAVRVLDDDVVEDAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLH8</accession>
    <name>A0AAD2FLH8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLH8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="202" mass="22524" checksum="7B46F9753EFDD5A3" modified="2024-05-29" version="1">MSFFQACFALSKGEIEPLLLFIVAVKTLSMKYPGASAITIAKTVDSLPASMRPLDLTERDLRETWIRAIYLIMDHVVDDFDAGTSDDDEVAETYGPVLADLVAIHQSGLGLNINQFVESRRDILLPVKEKKNILELENETDGENFVQLAVVTQTIRVLYTTLDILSEDDNDDNVKRDPESQSESPLPFEKKEKKKKGGTGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMV3</accession>
    <name>A0AAD2FMV3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="406" mass="44995" checksum="B42D2D36B677195F" modified="2024-05-29" version="1">MIKTPSNNDNSSVSNDESKPEGFCLFQSTFGTACAIVLWITCMATHDCWTDCNDAVTKASILGFGIFVIFMLLVERAFEPDETLCDAMQGMGKEFDDVKTWFGKIGYLAYNITVFATLVAELNALLDTNTPMWYREQALYMYAFLMYSNAAGTKLWSILHTLTFALASDSIALAQSTQVIMNPRSIGLILGYCGMAYEIVQRRDDAAFLKDHLPVRSVLFFTLIWIPLFCTIWPFAETSMMNYLVIGICLLLCSADLSKVGKSDGSYSWMERSGAHLFHASIWSQIALVLLEYLEGSTGTRNLWIIGFLLYAHIGSINVTNICFVWGITVLGAMNTFGDGKGHFPFTTTVAVVRTVVMVLALVDLCLNGKKKDDEASKSDNEDEAQVKVLWDGSDATDYVPLVNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNB5</accession>
    <name>A0AAD2FNB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS11033</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNB5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007599">
        <property type="term" value="P:hemostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000011">
        <property type="entry name" value="Coagulation factor X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041932682" description="Peptidase S1 domain-containing protein" evidence="16">
        <location>
            <begin position="19"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="17">
        <location>
            <begin position="87"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="322"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1947211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="587" mass="61943" checksum="B580BF32C81A331B" modified="2024-05-29" version="1">MKYSSLLVGALLQTTAYAADQNLRRTDVESKPLEKPNKEAPHKHQPRGAKSSDTVTYFTMEGKTNMKVKKEKKEGTHDEGDGRESRIVGGSQSDPGEFPYYVDLGGCGGSLIAPNVVLTAAHCGSYQGESVVVGAYRYDSTANNAVRVSVSADVQHPNYDDFTEANDFRLLRLAQDVTIGGSSVVLSINEQSSRPSNGEDLTVLGLGITSENGSEANILRDVVVQAIPTSTCNQPISYGGDIEDNMFCAGVNGGGKDSCHGDSGGPIVIRNGNQHVQVGVVSWGDGCARPNKPGVYARVSSAFGWIEQVVCDQWNVNADFCGGGTTPTPPSPTPPNPPPPTPTSPGPTPPPPSPTPPSSPTPPSGGGDCPTGEMEFDFTIRTDEWGWETSWEATRSSGSKVASGLNYQSNRTYRKNKCIPEGCYTLTIFDDYGDGLSSDGNYELKVNGQVVESKSGFDFGYERSIDFGSCSGSGGGGGSGGGGGGGSSSCLPITLNLRTDDYGYETDLFLLTDRGNLVWNANGFADNKDYQFSTCLDNSECATLDIFDEWGDGIASPGYIKLVVDGTTYFNGGDIGGGIVFRIGGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP10</accession>
    <name>A0AAD2FP10_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001738">
        <property type="protein sequence ID" value="CAJ1948063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP10"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="233" mass="24995" checksum="63FD374667F57B4B" modified="2024-05-29" version="1" fragment="single">MHQTIGNSLRVLVTLNHPFNINAAKQLVDTAIANAVYAHHCSYHGTITATLGSLAFHRDMDGFGSDPLDVGEAKLEFDMDMADAKDIDDGATVAGAMDELLEKDSQLEAAITEIEFKDNLLSEQNSALEAERLRSEQLARELAAMRLLQQPSASRTDQPTQLDNNGPSTKSPTEEDIPLTEKPHSPSTPARSNKPGPLTSPLPGSPSPPGPKTMLPPQNAATRPKSLVESVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPF7</accession>
    <name>A0AAD2FPF7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPF7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="274" mass="30476" checksum="9392DD623506A3F8" modified="2024-05-29" version="1">MVMQSQVVASAFKSPGLTAYKRSYQKKGQKDIHEQVFGSLSEIVGDHHVPKRVVYPGCHRHITASLCFPNMDYVDCDKKVANVYQDEVVKDWILSETQEQSSTTTTIARPKWTFTCTSYAAMAQNAKFEDESYDLMISLSAGIVSEPCSRYIRPGGHFLVNDSHADASAAFVAKDESSNKTAKLFRLIAVWKDGLWNTADLEDYFQTTKGEYISVEQAREAAEIGSVSKRSFRLLKGAPFYLFRKKAADDGDTAAAAAAAGESKGQSRKRRRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPK7</accession>
    <name>A0AAD2FPK7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="418" mass="45984" checksum="0953EB62BA0EE622" modified="2024-05-29" version="1">MMIGKCVFARCKSLLEIKISSIVESIGQGAFSECEVLKKVEFECSSSSLHRLKSIGYGAFKRCLSLQRIKFPSSVNMIDQYVCSDCRVLVEAILSKTSITKVPNHGFAGCGSLQTVSLPSSLECICSYAFKDCNSLVTVMVPLDSKPIFIEISSVMNCGSLVNLVLPQGSEETTSSEAFQGCPLLENRFGKGSESIVAGLVHRFDNFPVHKMCYDHSSITAQELCECVQSTMGNVLPLVDGFGMTPFHLLFSTPEPSEDLLKVLLDHDPYHAILDRKDANGKRPLDYLMSNWTEITASLLQKSLQKWMVDPLASWGAASWMEAMQSKVQAVLAANNKVQRAYLYHGAYTVFEQYKAMGSISILEMALWKLQLRGGWNNDGTKRQALDRRACRCVCGSDAAIPRIVAFLGVTVTTSKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPM3</accession>
    <name>A0AAD2FPM3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001752">
        <property type="protein sequence ID" value="CAJ1948725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="276" mass="30461" checksum="3ACBA09CE41FEFA1" modified="2024-05-29" version="1">MEEDKSKQAAKKTDIFVHGDVSSVEALIKMLANFFAFVKYCVKDFTFDDPPLIVTLLEDFMNALHTPAAKDWIRYNAAVPHLPLCLLLEMNQILQIVVGAAKNKTTQSKLRNGQPIMADTFVNAFSGVTQAISHTNLSISMGNLGPYGTCPNLHAILTGKPTPAPKRESPNSRERPDPTKRAKHPPQGTHPGYLTYDGPGRLPIAPFKCKHPITGKQAAFCSHFLFANYHCNRPRCHNIHYTKQFAATMGSADTQAFEKFIEKTPGVTHSAPKPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQD4</accession>
    <name>A0AAD2FQD4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="56"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="129"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="276"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="349"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="427"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="500"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="578"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="651"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="729"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="802"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="880"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="953"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1333"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1646"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1653"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1684"/>
            <end position="1693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1701" mass="194205" checksum="FA9FB5A43306B142" modified="2024-05-29" version="1">MRIQVFTPKGEKVVVEVDPNDTISDVQAKVEAEAGLDRDTQRFTIHGERNVFQEPMNIYVRDTTGRKFLVDNVQPLDSVGDIKKRIEYQEAIPAKDQYMLFGQTALNDNSQTLFDYGIKHKSIIDLEPMTIFIKTIKGDIFELMVEPKDTVADIKRQIFEQKAVPLDEIILTADGESLTNNSKLSDCGIKHRDTLVLNPLTILVKDGTNKGQGKMYTFVYEATDAIEDIKNTIVDVIGIPMHEQLLSFEGEMLIKNGRTLRECGLKHQSMLDLEQMKIRIKTFQGDKFKLDVEQTDTVQSIKERVMEKKGIPLKDQILMFFEDRLDDTDKTLVDCGIQHNDKLEVEEHMKVIVQDDTNNGGGKTYVFYTEETYPMSKISAMIADEVGIPEGDQLLSYSESMINEDSMNTTLKDYGIKHKSTIHLVQMMINIQTFQGDTFDLPVEPTDSLQSIKDRILEMKGIPLVDQIPLFNNKRLGDMDQTLLDCGIYHLDGIVVEEHMKVIVQDDTKNGGGKTYVLYTEETYPISKISEMIVEEVGISRDDQILSYQQSLLDDQDMGTTLKNYGIKHKSTIHLVQMIVHVTTFQGDEFDLSVELTDTLQSIKDRVLEMKGIPMKDQILWYDDKRQDDTKPTLLDCGVAHLDKFVIEEHMKVFVKDDTRNGGGEVYTFYTEETDPIDKIAQMIVDELGIPKETQLLSFKDSLIEDKDMGMSLKEYGIEHKSKIHALQMKIKVNTFQGDKFKMDVERTDTLQSIKERIMEKKEIPLKDQLVFFNGDRLDDTSLTLVDCGIEHNDKLVIEEHMKIIVQDDTKNGGGKTYLFYTEETFPISKIAEMIVGEVGIPRDDQILSYEDSLIFEKDMDSTLKNYGIKHKSTIRLVQMIVSIKTFQGDTFDLSVEPTDSLQSIKDRVLEMKGIPLKDQLLWFNGNRLDDTDRTLLDCGIEHLDKLVIEEHMKVLVKNDTKNGGGKVYTFYTEETYPISKITKMIADEVGIPKGDQLLSYQESLISEEDMGTTLKDYGIKHKSTIHAIQMQIKINTFQGDKFNMDVEKTDKVKDIKDRIKEMKGIPLKDQILWYGDERLSDKTLSLTDCGIHHMDTVKVEEHMKITVQDDTKNGGGKTYLFYTEESDAISKIAMMISAEVGIPKEIQLLSYEESLIGIKDMGTTLKDYGIKHKTTIHAIQMTVAVKTFQGDKFDFEVEQTDTLQSIKDRVLDMTDIPLIDQVLFFDEKRLDDMNQTLVGCGIQHLDKLIIEEHMKINVQDDTKKGDGKVYMFYTQETFPISKVMDMIADEVGIPKKKQLLSYDETLIYDKDVGTSLKDYGIKHQSTIHLVQMMITVKTFQGDTFMMTVDPSDKCQRIKQKVKDMKDIPLNDQILIFNDRRCSDMDSFKICGIKHGDTVFIAQAMKVNIQDDTRGANGKIYTFYMEENDIIHDVAMLIQDKIGIEKDKQRMTFNDEKLEEEDKSLKDCGIKHDDTIHVKKSYIPVDWKKTVEEKYGKVKVTTYNVDYTLDKGVIAGIKDEKEVEIDITGRRKSEMVQQQMDFMAKSPSKYRKSMMTNQEFLDEMASPKKTPTKNRQSMMPIANAGLLEETATPKKTPTKSRQSMMPIASAGLLEETATPKKTPKKNKKAKSIMTDTVLLEETDVLEEMASPKKTPKKKSKKAKSMMTGTALLEDSDILEETATPKKKKKKKKAASVILEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQU6</accession>
    <name>A0AAD2FQU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQU6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29180" checksum="DFC244CD779103DD" modified="2024-05-29" version="1">MTDNWDDSDDEWDVDDDALDAKLGIAKPAENNFDDEEDLALKEKQAEENASKDVLKKKGSALAARKKEEEERKLEIEVARKELEYQAEMEAKMTPDELRAMERRRVEEADHALTDDLFGAVEKMTLDNKAGDKSGGDKLVLKDMKDHMKHARKVATCMKDHGKVHLAGIFLKEVIQQSKDVLDDNTISDIIKACNVIKNEKVQQAKKKVKGQAQKSKKQDKVEKQKAKKLHDEVFGDNDMYDDYDAIGDDYEDAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQX8</accession>
    <name>A0AAD2FQX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS12426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQX8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="DUF6824" evidence="5">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1950108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="476" mass="53817" checksum="F700FF7443B679B5" modified="2024-05-29" version="1">MATNHDVIFGKGNGRNPGNQYWVHLVRQHLEEYNQATNRNETRSIAKSVIYSVHQNGGRFLKKDGKNGGYMEMTKEEKLHKTRQCFVDLNHRGEKNRNEEPPSSIQLAPDEVAVAPDASTILLTPEERLDQQLHIRRETQPEEVSKTYNALAGLLFKDGKLEEDQELYQAAIRQYQKVLAIHLKVHGPDHSETADTYHNIGHVLCQQDMSEDAMDQYKKGLEIRLKLHGTDHLSTADSYHCMGMVLFNQAQYEEAMQLYQKALAIKVKMQDGPEDSSMAASHYCIGNVLRKQGKERAALENYHKALAIFLKVDGRRHPSTASTYHSIGEALCNQGNYDDAMDQFQIALDIKFKLYGTTHSSTLSTYRSMENILRKQAESKNTQVNANVPEPSGDTTPQNGNPARRPLPTQQTNNTVVHQLLQAQLSIHKAQQDLQTQQSTNPSEPLQAQQTNNTVLQQLLQVQQDIHSALQQLYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTH1</accession>
    <name>A0AAD2FTH1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS13667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001813">
        <property type="protein sequence ID" value="CAJ1952679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="684"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1952679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="753" mass="85046" checksum="D9C2552B61D2CE90" modified="2024-05-29" version="1">MITYNRSAFGLNLIFRVHGSAVYRSILPSLFSVGLYFLVHFRSQAGLSYQEQQDLGHPYAIGVLVSSITFLIVFRASQGYARYWEGASCIHQMMGKWMDATIHSCVYHLQCDHYKDIKPPSYFDYPELNHLFLTRDRERGADYYDQVEEETEHPLDDDLPGSARSRSYPQDFRDGQGNGRRDPSPGRLPDGRRMARRLSSPFSANFEAKKIERKIQKDKQREQLERAKVKSINSLSVPADSRSSIRSRSPLLGDIGEAAELFNESMSSNTDGKFFEEFLDDSEREYGDKPTPLVGRPRLDGNWSHLYRENRQVFVAEDNNLKGFASIDGGRTPPLFLQELAHLSSLLVAVSLSTLRNDMEGFESPLSYFQPGQPWPEVDPDRDEILKHPGKGHRLKALFTFLGMGRSPKEQTRYNASRPLPVIGGVSDAEIRFLQMARGPYAKTQLCWNWLSEFMIREHLAGSMGAVGPPIISRCIQFLGDGMIYYNHARKIMFIPFPFPHAQLSVMFILVLVPCIPFLMEQYVDEVWLASTLTFLTVMCLSAIHEVARELENPFRNVPNELPLVTLQAHYNETLITMYSGWHPDQFWDGDRILRRHKRRAGGAHGTTQSRGSKHNAEIADLKSQLAEQAKLIHKISQNLDQQQKGRSSMMRENSFHPRYSESGARVSTDPLVVPESARKIRNGANESVSSSSFSIDESEDVPLAAEGPLSVGMSGDGPLRVDMSGDVHSQSSEEDSKDLAGNPNLLEEIAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTV0</accession>
    <name>A0AAD2FTV0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS14011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">JanA and janB regulate somatic sex differentiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the janus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.20">
        <property type="entry name" value="Janus/Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007702">
        <property type="entry name" value="Janus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038596">
        <property type="entry name" value="Janus_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258:SF5">
        <property type="entry name" value="BCDNA.GH02250-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258">
        <property type="entry name" value="JANUS-A/JANUS-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05005">
        <property type="entry name" value="Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143724">
        <property type="entry name" value="PHP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0726">Sexual differentiation</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1953400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="16402" checksum="12823C82CF407DE4" modified="2024-05-29" version="1">MATTNAEDQRKAAELQARLANAGDKATTSSNDFARVPNVSIDAGAHKYVLISACLPGGNIRENFVVSRRGAEYHRDAAEPFIEILERNNYSSIRILGGGRIALDIANKTCSIYGYSYGFGLADHAMSKAVVERDDRYNDYDITWSNEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FU27</accession>
    <name>A0AAD2FU27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001827">
        <property type="protein sequence ID" value="CAJ1953520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FU27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041921836" description="Thioredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="143" mass="15300" checksum="3438C3DD4368CFE2" modified="2024-05-29" version="1">MIARYSILLVSALALCLSDAFSPVTTSPRHRTNVMAVVDIDGETAFDNTISSAGSSLVVVDYSTTWCGPCKVIAPKFDELSEKYADAVFLKVIGDASPDASKLMKREGVRSVPSFHYFKNGEKVDVVNGANAEAIEAAITKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUY6</accession>
    <name>A0AAD2FUY6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS14346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUY6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="260"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="426" mass="49745" checksum="A71862ACF139802B" modified="2024-05-29" version="1">MTSNGECQTANATEKEDWEIQRDYHKSLADAAFRVGAFRTAIAEYSKSIDLEKPSEEVEEAQKPVAVSKLLLVLYSNRSAAYLRNSEKSKALKDAQMCVELDPKFIKGHSRLASALHSLKRYEQAHDAYNQVLKLDATNPPAKKGAAECAKALEAIKQQAFELEQDRKERLLAQEQADEEESKGLEKEKDEEKQQSPEEAEDDLLNDFFDEVEEVTTKKEDELKADKATNFIKNDRKTLGSAKQQMDRLLQSNYEWRNLNPFYVLQLPVEATDDDISRRYKALSLLLHPDKSGGSDRAQLAYDQVQKAKNTLNDPDRTRHTRMLIEEGMKVGQRLWKTQKAGEKRTLQEVEEREIMRLFAQVEQKRKEVTQRERQFQQREQQQEDQEMEKERKSRQFDKQWRDEGRVDKRIGNWRDFQQKKKPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVU0</accession>
    <name>A0AAD2FVU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS14947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVU0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1954355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="56996" checksum="99D12373A471F1F7" modified="2024-05-29" version="1">MDSNKDLLSQKDESSLLCGVAVACYGCTPRLDDEEGIPDGESVKPASLAKKRRQIDEVLGWGLDASARGVILMATAVFVSSELLRLAKEASVCVDSSEERGGEEDCRVHGMRPTSVLTNIVTITGLLSALIMPLAGSIIDHTDHRRAVGSISAAAITVFIFIQMFVMEDHWVTAAILQILVSVAYTVHLTVVYSYFPELTSDHGELTKLAAHFTGVQYGSSVAFLVMMVLILEAVNKDEEVNSAFLAQEVVVIVCCIFFATSWIRLFHSRSASQKVPENGSLVTAGFRKIYKTGKKILKDHAAIKWVLISVAFTEAATTTFATIAITYMTEQLSFEAEENGIAILILLLFSVPGAQIATRITKIFNPIRSLQACLCLWMVSITAAAVFLKHEGQQSLAYTFAVFWGLALGWTFPTEKTLYVTVIPRGQEAELMGTYICACQVLSWLPPLVFSMLNEAGYSMRLGVTSLAVFMLISFSILFLVGDYEQAVAHAKAVDEQQKQLSSGMKTSRTEDDHYREMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW44</accession>
    <name>A0AAD2FW44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS15295</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052:SF81">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041955377" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="13">
        <location>
            <begin position="23"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="186"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="280"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1954703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="83013" checksum="E2B9AE16D427D92B" modified="2024-05-29" version="1">MKFLSVLYCACLLLDASIEVAARTNNGGNLRTIEMRANGDRNLAGKGKGGKGKNNKMDTTTSTKDGKGKGGKGGETSKKSSKSSKKSSKKSGKGGKGNVSMNPSSMPSQMPSQMPSAYPSAMPSGYPSAMPTKTPIAVSNDAISNDAISVDEGPISIDEGPISVDEGPISMDNGSFDDANNLSVDDGDRAGTTPPAGGTISFPTSEPTAAATKAPVVRLTKNPTRSPTIDLSDRTEVPTSEPTATAATEAPIARLTKDPTRSPTVDLSDRTGTVGPSLIVVPTVEPTLVPTKTPTVAPTRTPVSLQPTQTPTGRPTRAPTGTPTKTPTTQSPTASPTSKPTKTPTPTVTPTKAPIVTVPTRAPVTPRPTPSPTKAPTKAPTTTPTKSPTMVPTEAPVGTSSPTVTDRVGGDDGNIIPLIAILQGRLEPNSYFGGVEFEDPSSYQYKALQRVERQEGSESLSAQKLIQYYVLYCIYYATGGSGWVTADGWSQDDLAPCGGFFGVSCDDDNVIVGINLYDNGLSGQFPPEVTLLASDGYRSTGAGNLRSLDLYLNTGLGNGNDSHWVSELGSSLKYLFIGKTGFGGSIPKLPSGIIEFDASHTQINGGLVASNFEGLDHLTWLLLDGCTFQTSIPTEFAQLPSLEYFYISDAQITGDLSYLEGMPKLFEHFASNNPNLGGALYSFIGDIQTLGSLNLAGNGLEGTIPASFGNLDNLQQLWLNDNSLSGQIPAELSELIALQTLELQGNNLSGDFPQAICEMKDPGYSLKKLGADCSVHKCECCDCCSTEFCQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW62</accession>
    <name>A0AAD2FW62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS15340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FW62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="entry name" value="CHASE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF28">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="13">
        <location>
            <begin position="214"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="459"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="727"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1954748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="97227" checksum="76C36EC305A2DC42" modified="2024-05-29" version="1">MDTRDPCKQVVKFDMESDSQDQRTQPTEVNIVEFDVENGHKDLDLNKKYDDDESSSMSSNALNTNIWNRAAIISAGIAIFGILAGTLFLSYGIAASNTSQERSFRLVADETANEFELAAEDYVTAAKWLHQACAYHPINRTDFRDIYEHASFDLTFQTAAWVPRVYNDERAALEDSSLEYYGENYPDVNYRGIVGYEPDENSISGTSVQNRTEQPFYYPVHFIEPVETNTEVIDLDLYSIVRVAVDQALETFLPSATAPFVSSRDPITEITENSILLLHPGIPLSSHPDRKPEDLAALRIQVKDWLQHASRNIPESIAVYIYDITSSETEPIFVIAAEVHKNGTGDLDTNIILLKELTLEELDADNLLYQDSIIRTGSREWKVRAVALDGTFEPVILTVLVASIFILVASVFMALWVFAGMRRNLNMNRLKRDNDAEKAALVLKSAREATKMEQELNDYIAHEVRNPLSAALSALTFVKSEIGEKTSVKTKEITDDIQIVDSSLRFINDLLRSMLDFHRAKSKNMKLQIEPFDLEQDLLLPVRAMIYTRDSDVKIETNCPPGVVLKTDPIRMKQVVLNLCRNAVKFVHKGYVRIGATVENGLVVITVEDSGPGIPVDKRQHLFSKFQESLDALNQGTGIGLCLCRNMVDLLGGDIYLDESFESGIEGCPGARFVINTKLAPMTREEIEQYVNSKDDQVSTSLKFILDDELMASQDIDKDQELPEELSVLFVDDDLVLRKLFSRSVRKVSKTWNIKDASSGEAALELVAEQNFDLIFVDQYMASVEKQLLGTETARALRAKGIKSIICGLSANDVEAGFFSAGADFFMFKPFPCRPEELKQELLRILYTRRKESLAEMSTTSQLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWJ0</accession>
    <name>A0AAD2FWJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS15358</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="191"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="414"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1954766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="657" mass="71823" checksum="EEFF08F385AD7A14" modified="2024-05-29" version="1">MGDDNKAQGGPNTANGGGGGSGDRKRKPNPNNRRGRGRGNGPAKRQERDNTNNNNGNSGNNGSMEVDKPLSNSRNNGNSNGNNGNGGRGGQNNRNRNNRGRNNNRNRNNNNRNNNNNNIKKEVEPKAEAMDESNEPNVASAAAPTGNSGLHITDKRFADLEQVCDESRRAMAEVFKYELMTEVQAKTLPVILDSTRKIDVLAKAKTGTGKTLGFLIPAIEKIVQSIKTSRSDKNDIGCLVISPTRELAYQIGTEAEKLVTFHTRPKLSVATCVGGTNVNKDRSTIKRGFLSILVATPGRLLDHLQNSELNLQNRLAKMDCLVLDEADQLLDMGFRPDIERILRLLKPSEGSRQTLLFSATVPKSVAEIAHIALQPKYEFIDTVGEEEEQTHSHVKQEVMVAHSSNQSGGMGEAQIRAIAAILDRELKTGTKGAPCKVIAFFTTARMTGFMAEIFNSVMGKTGFPKILEIHSRMSQSVRQRTSEKFRASKENTILFSSDVSARGMDYPGVTFVLQIGLTERAQYIHRLGRTARAGKGGCGALLLAPYEEKFMVNKNLADMPLESVDVPELNNRLDDAMTQALNGVNDNKSLKESAEQAYRAWLGYYNGQLKKVGWNKIALVKEANQWASDVGLKSQPALLKKTVGKMGLKGVPGLKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWU7</accession>
    <name>A0AAD2FWU7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS15452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWU7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1954860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="67184" checksum="22F6A065EEE447E5" modified="2024-05-29" version="1">MPLSYQQEVALAVVPKVSSVFSLFGSIWIIVEVATEKTKRGVPYHRLLLAMSVYDVLESVWNFLSTWPIPKGSPDVIWNFGNTGTCTAQGFFLTLSSAVPLYNAMLSWYYVLVINYNYSDTRLRGFVEPAMHTFCFVWAFGTALYSALAGLLNNADLWCWIAPLPADCKDSWTHGSGPENDNPCIRGDNVWIYRFGFYFIPLWMSIAVATVSTYMVWKYVFHQDKKTLRYRRPQRTMSLWKNGMKSFRNDVKKRFSPAVPVSGGSNLGQIVESDAEEEEVGDEHEKGKESHPSVQKKELLDANKKATSPDRSLGALSKTKELDAVGDIPGAYGVSSAPPDRNSGGSHLLAKDRKDPSSLGLRSVPESSEGVYHHSDDMSKQRSSLEDNTPHNLKHSMRELSEDRQPTGAWSLSMKRLERSQSSSVRSIESCDISAAQDELAKRKQKAESEANERIERREAKKANGLLARWKEWKEKREQYAQDMPHTVEVFHQACFYLGAFYCTHVWSTTNRIVQTITGGDSVFFLLVMHAFFDPFQGFLNYLVYQRPRYIQMRKKFPDLSVWKICLVILRFSYMGEYVIPPIQSSTEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY80</accession>
    <name>A0AAD2FY80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY80"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042160409" description="VWFD domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="499"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1956425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="755" mass="82887" checksum="D06F8403B1AD5746" modified="2024-05-29" version="1">MRLSSSLLLLAVGASAQFSFPPPPGDTTTTDPTESFSLTGPPPPGDTTTTDTTESFSLTGPPPPGDTTTTDTTESFSLTGPPPPVDTTTTESFSLTGPPPPGDTTTTDTTGSFSLTGAPPPGDTTTTETTDSFSLTGPPPPGDTDGDSFSFPPPPGDTAGDGSTTTDSTSISDPSLLSPPDTSNYYFPNKHEKPFGYKYHGEEKCAIINIAMDESGSMVTEQQFMRDRAVNKMVRFLNGNKHQFDKVFVCSNGFGNNPGGNPDADPEDGYRHLGCSLGYDRTILQWSYWNEGRNEDGYAATIKSINNVPEVIGGVNITSTCRTAALNMILVTDEDRDAVTEVTKDDVRQRLTETGYIYNIVVNVFIKNDAANIIGMRYNYNATDYPRLTMPILDRETGTFRFYGGGDIPNEIFSAKMEDGVIHGEYVEEMDPSLLYKELMTNGHGHTIEDYGEIIEGTKGTIFSIRTMRKGTRGDVPGLSDAFANALVDIKICEMTRCRDPEIGGDPHITTWKNEHYEFHGQCDLVLAKDPKWGGGLGLDVHIRTKIVRYWSYIQAAAIRIGDDILEVEGGTEMNTEPKFWVNFEYLGDLTTFAGFPVTQDSNKIHRRSYTIDLDSKYKGKKIVIDLYREFVRVKLDGGLETFGNTIGLLGDPRSGALLGRDEHTEFNDYVDFGNEWQVLPADGMLFHETSHPHFPERCIEPEDPQGERRRRLDESSITIEQAEAACASLKDPLSIKDCIYDVVATQDLDMIGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY96</accession>
    <name>A0AAD2FY96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PS II complex 12 kDa extrinsic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041899300" description="PS II complex 12 kDa extrinsic protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18076" checksum="94C99B6B7763AABF" modified="2024-05-29" version="1">MHSTRLSVLYILLTSSLLASVLLGWSATPKQGASRRVFLDTAAKVVPLVALSSPAFADDEAASAEPISVPGTTPVPSTEENECIARLKKQSDANKEKYAQQAIRSDKLSNGQFSTQYQRPSYFGVRRTNGSFEMVDPSELDELMKSGKVESTFDKMSNKTVYAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYG7</accession>
    <name>A0AAD2FYG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="361"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="454" mass="52622" checksum="BCB87E49680DE6FA" modified="2024-05-29" version="1">MAMAMTENRSIFSCFGCGEEPKHHVVTTSARPSSHETTPEIEEFLASQMSKLSVEERDEATHDIHCVGEDILETPEMVETSLAEFDNAIKREKNETYEIAMAQNRAYVEDASFRLKFVRANMHDVNRSVNMMLRFLEQKALHFGIEKVARDITIDDLTDEDKKFMQLGLFHIQEGRDRSGRIVFYYFNRYVGSLNPATVNRIFYYVVFNILINMPTAQLKGVNGIYYDVVKLKKDAAVPGFNYVKTFVDFWTCIPIRFSSTHYCLKRKNLARSDFILKTALQAAHKYVQARTRVHVGSDIELQYQLQGHGIPIQFCPVDGDGKYRTEILNRWLNKHESVPASNQGKDVKKSKQSFVPLRHDVLLGRGKSLQTHLGNICFREFVKQYSEEYDETPRNYRRLVPIKVIQDLKSRGIRFLRQDESTGEWVEPEISDIEKTVGQVFRNLRKKHKPESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYX3</accession>
    <name>A0AAD2FYX3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001940">
        <property type="protein sequence ID" value="CAJ1957377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1957377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="109" mass="12305" checksum="BDA028900A85F9CF" modified="2024-05-29" version="1">MIKDSEILVEQRKFSEADSSSKEPFNKIFDKGFRNTLDASMEGQTCTQPTYSKGDTQSSGKATLYLACVAVIRSGNERAVQRCKMSWFLKRGCAYQLLDIELFCGIWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ20</accession>
    <name>A0AAD2FZ20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YchJ-like middle NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001939">
        <property type="protein sequence ID" value="CAJ1957358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048469">
        <property type="entry name" value="YchJ-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33747:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE-ASSOCIATED CAP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33747">
        <property type="entry name" value="UPF0225 PROTEIN SCO1677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17775">
        <property type="entry name" value="YchJ_M-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042085148" description="YchJ-like middle NTF2-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="YchJ-like middle NTF2-like" evidence="2">
        <location>
            <begin position="94"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="212" mass="23661" checksum="6CBAED9D730F1DD5" modified="2024-05-29" version="1">MVSCRCFFVALVLLLVTLDCSYAFAAKKKGGGKKRASTPKGFGAPPPTLEEVLGKFRNRVPQDAESRPCPCGTGKSYGECCGPFHGGSPCLTMTDVLRSRYSAFAWRNIKHVMATTHPVCRDYREDKVEWAEDLNKSGMFDSFDFVKLEAGPEEPSADQENEGYMTFKVILRAKENTGSDLTGKETIVKEQSRFLYDSDDGSWRMLQNIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ40</accession>
    <name>A0AAD2FZ40_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1955127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="608" mass="67226" checksum="BB248E8EED1C2053" modified="2024-05-29" version="1">MRFESFGTVDSLEPINETSTMAESNAWKEGLSMTAGLAARNQINPSGLSNSQLSQHTQSSSIQKPNNLQVNIIINNRTNSNGACYNPNNLGVDADNNIAVSQSSNRLSSPFDLSFDDPLGGFPNKTSHDLQNQQSDQVPSQPQHVSSLSNMLTSWQAADQYPSFGGGSDSSTLLTMGNNKESTSNTSQGRANKIISNRFLLGCKVQPFTRNDDEIEDDDLFKVFDDDLGSHTTKKLQMPKTQPIRERVLVPDYPAVSSVSDIHQQAGALQRQNETIQNIMISNMEQGGSDPSVRDFATLRQQEHQEEARMQKLCRVDKPSDESSRLVSQNDETEDSFDTQFYVPSTMMPPTVLASTLPSSFNKRKSGNESSERKRPRVCSNGASPQQKLEELLQKAGIVGFRRVKADEAEYEVVPSALQLASFGTRVVKAVHTSDEKALSELMKCGLSPNPCNQFRDSILDLVCKRGNFVIFDCLIQHGTDLQTMDGFGRTPLHHCCWASSFCRPIVDAILERDPMQLMIEDKRGQTPLEYVRADLASDWIHYLESSLHKYWGNTIPTLSSPKAKRPSGTLPDPPNAMPVNLAAMVSSGKLLPAQVIPMIKSRKLKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZZ9</accession>
    <name>A0AAD2FZZ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001969">
        <property type="protein sequence ID" value="CAJ1958222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="617" mass="68235" checksum="5DB24033CACB4B4B" modified="2024-05-29" version="1">MSEYFAKLGEGGPDDHLRTHARNGPASHDEATIQSAPTTSGASTGTRRRKNNRSSSLSGEAQSGQHHEQHEAKSNRRRRRKSVQKSLDLALGHSSEKFENSISHSIAASIASAPTVQHHVRRSGRRSGPGSKRHHVSLSPKRNSEGQPRSTKRSLSPHRATGGSRAVQRSISPTNRQVSRDNSRGARRRSREKSPGQQSPSRSLRGGRKINMHDSVSTSGVQRSISPTNRRVSRDNSRGARRRSREKSPGQLSPSRSLRGGRQSNLHDSVSTSGMMSLARSAATEPTTRKARHSRSPHRLGASKADGASVTSPGTASTPKSRSMSPLIKGHRGPSALVSLLEERKEPEQRIRTRGQHTHDSNQKHKISDQERKRRHSHDNSRHAEGAGKMPKPPNLPQRVQSDIIGGHANDVNHKHKISNKEKVRRHSHDNSLHTKDHPRLLKPTASTRKIMDSVVKVLSLNQQRASVTSMFSEDDWGESPSFSEAFKPEPTAPPTQPTQRVTSKSHRMKVEEVRRDHQSADHNSDRRRSRSVDSSTAQLHSMTTATSSESVMSRQKSARSGRRNDPRSKSLDPAASRIAEDGPFSSSSSPFAVMPVDRERLAGPRERWGRDASFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1D7</accession>
    <name>A0AAD2G1D7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1D7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042134020" description="Steroid 5-alpha reductase C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40182" checksum="16410371B5EB5B70" modified="2024-05-29" version="1">MLRTKILLGLAILIGSCQGFSTTFSTRSNYVVNSNVVKQEPNKKSLTLLTTTSTHQRSTTTKTGTSLSAVTIPPEVLTSFLPPILGFYRSEFGVSYAYGLATALSGVSILRRFSPATNTVLPMHAMALIFYGFRLNAFLAIRTLLSARLRAFIDKIEERAKARGNRLSRAPFIISCGFLYYGLAAPLFFTSQLTSEMMKPSWVLPFMKTLVGLEWFGFGIAAIGDFTKTFVKKTKGDDTLVTSGIFSLLRHPNYTGEMIGWTANSVCGLVGFTLLAKAATSRAALLKLIGNFIIQSLGLVGITFVLMQATTGLEKRQQEKYGDKPEYASWVKSSWGGWTLPAKKEMKAESKIELDESQIEEYGSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1Z7</accession>
    <name>A0AAD2G1Z7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1Z7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042049681" description="Rhodanese domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="54"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="173" mass="18536" checksum="90C301EFBFA16283" modified="2024-05-29" version="1">MQFLSMFLFLVGAPIVSAFTFFPTGAGISSHSSSSSNSMMLFSVTDLKADLKLNPTGTYLLDVREAAQWAEGHLASASPNPLSQLKTGKWMDNATGKFAPGSFPIDRLTGVGIMMNRKIYVHGEEGGTAKEATELLGRMGYKDVTALEETFDQLAAAEICDVVMGEVQDLTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G215</accession>
    <name>A0AAD2G215_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1960026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G215"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041985770" description="VWFD domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="56507" checksum="B610F2B3D27F98BB" modified="2024-05-29" version="1">MKLIFSSTFLFTLAVATAQEKAQSLRKLQQSEPINFQGDGCMSYDPSDSDWVTLPYDDDYDHLVAMGFPFTFGATTYTDILINSNGHLHFDFGSSDEWHYAADGFVSASDISIAPFQADVNNVVTGHIRYKLAGDNVAVVWEEVGHYLGTADNTNSFEVVLSSNGSNDPKICFCYDKMGWALDGNSPQLPGEVGISIGSGSGFLLGDFSQTDATWNGIGSSDNGVGYLTGKSFCFNPDIVNSSNPSKEIISTFGPGTGGDPHFKTWHNEHYQYHGQCDLVLAKDATFANGLGLDIHIRTKLVRHWSYIKTAAIRIGNDILEIEGSGKGLDKEVRYWFNYEYQGDLTEFAGFPVTIKADGSKLQKNRIDIDLSSKYPGQKVTISSFKEFVKVDFTNPTSKAFGNTVGMLGDFESGKTLARDGATVLDDYTDLGREWQVLPTDAMLFHESSSAPQFPELCIEPEDPRGDRARRLGESSITEEQAEAACARLKDGLDRKDCIYDIISTEDMDMVGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2N7</accession>
    <name>A0AAD2G2N7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001961">
        <property type="protein sequence ID" value="CAJ1958028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2N7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17556" checksum="8E4D256EBA88378B" modified="2024-05-29" version="1">MKWMIDASFAVHPDFKSHTGGTLSFGGGAAQVMSKKQKLNSRSSTEAELIAVDDVVTMILWTKLFMEWQGYPIKKNVLYQDNKSAILLEENGRKSAGKRSQAINICYLFITDQVEKGIVKIKYCPTDNMIADFMTKPLQGEKFRKFRDLILGPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3A6</accession>
    <name>A0AAD2G3A6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3A6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="327" mass="36855" checksum="F601AC1D47C0A3D2" modified="2024-05-29" version="1">MPDPEQHSQENVNNNNNNNNNNSNSNSNSNSDAIDDENDDYDYEFMKSMFGGGNDDDDDSSDDNDDPQVTEYSWSCQQDDTKVIYHLAFLAPGHGDAVWNSSDCIAQHLLLEEYRTKKLFPCGKFEWPPESALEFGAGAALPSMILLKEGTRRLLSTDQKINEETFDALNLSFQKNAPQWGISQEQIQDRVRVLPHSWGVGMDQLREAATIDGNGNDDDDRNAGNIQLLIASDCIYDPTHHRALLQSVAGTMSRTKGRFVVGYSFHMNVPPHKVMQFFDLAEKEFELKITCEFQQDYNGQEGIGNHDPKRGAVYIKVLAHKNSDFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4H8</accession>
    <name>A0AAD2G4H8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4H8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="217" mass="24291" checksum="4DB272D6AC9861FB" modified="2024-05-29" version="1">MFEYLKFDSNPTFDVLASTKEYVASQGKVDNLDGWYAPDYVLRGPVIGPMTRQDLDGNRDGLGILEAFPDLEVENFGFTIDPENPYRCFYFQRWRATHTGDMDSFGQHYPATGKEMETPVSVFSVVFNPEGKIVYEQVGAVVDRHEGNTQGKAAVFGLLHTAGMKLSASPGDAVFSLIQRIGHMFGSENAGRSWSKEEDIPSWWQSPSRGADDTEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4I9</accession>
    <name>A0AAD2G4I9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS19625</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="9"/>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4I9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17748">
        <property type="entry name" value="BRCT_DNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="689"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="587"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1962314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="780" mass="87142" checksum="CC828948154E3503" modified="2024-05-29" version="1">MFLFLLSSRCIINVKSFSSESHYARAAIRHHLSIITTTTTTSSSSSSSSSSHTARFASLQSRDDTEEEDQTLSEKQKEALELIQRGENVFITGVAGTGKSLLLRRALQYLNTYYNPKQYVAVGPTGPTAIALEGQTIHSFAGIGIPRTMDDFKKVKRKRKQWKDLKAMVLDEASMVSGEFFDLLSNAVSEIRQDPRPFGGIQLIICGDFLQLSPIAPRRADMENMVVALQEKEGLAEEDAIEILFRNRGFCFQSYNWQKANFQVVELDQVFRQQNKQFIDVLQDIRRAQISPATTEFLRKNCQRPLPPNEFGIRPTILHSKNKDVLRDNLIELNELKGDTVEFQAKDDIIKEKGAPKWAENQLWKSQFFTNCIAEEKLQLKIGAQVMLIKNEGQGKKQLVNGSRGKIVGFRKPPPSIKPAEAALLLPGVEKYPVVQFISGVKKIILPTSFESRLIGIGSCTRIAIPLKLAWAITTHKAQGLTLDYVIADLGEVFAEAQTYVALSRASDEAGLELRNFSPNRVKANRIALSFYQDPNQEFEMWNGKMAPPMSSQDQARTAPAPVIQPPQNERKSFELWEDEEMAQLVAGQNPKPAKSSPKPSTSVNRVHAPKERQQYPHPDLDRLPLVQPHVSLRVKNERGRKIMTISESPRDQATVTVMSEQASVPSSPPPSPPPPPPLEPHAEPEEQSSSVSFEGKLVVFSGVLRFMNREKAENLVRENGGIVRKAVSSKIDYMVTGNKLGNGKPITEGADYKKAKAITAKTIQIIAEDDFYDLVKHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G510</accession>
    <name>A0AAD2G510_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G510"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="481" mass="53470" checksum="BD63534390982DD6" modified="2024-05-29" version="1">MPSANDLLEHITSSSSNSAPPQQGPQTECLLSKRPLPKEGEEKKDDSPNNQHHDPVITMGCAHKYYASALNEWRNDNPFGIPNYDSLKKACPVCYQKGVPPSKDAMASLQLHRMKLDKLQQDLNAAAASVSDDDPDNKAVLLEVPKLPGEEEYDQSIFSGLFSKEQIDQFRKLPEDKHQPFLKTFYEICVAQTQQDIAAFEATYGDIDVLLKEQLAAKGDNSIELPGEIFMAAMENDMVTVDKWLGVDIYNGIYDDKFYAKLNATAPDFTGGTLLHGACFGGHLEALTRLLQLGANQNKADSVGASPLFHACLNSSDDNHNQHGLEQNKPLQMAKTLLEWGAEIAPNLRDFLTSNKNSNDAHKELAFLVKTPLGGRRCEVVGLKGRADLNGKYGVVGRYFSKEDRYAVTVTLAQDNTEVCKIRSVNIRRKDRTPKDYMDVRGAMPVRPLSRLEELRIKKQQLETMILNSNNNSNGNSSENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6J9</accession>
    <name>A0AAD2G6J9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002195">
        <property type="protein sequence ID" value="CAJ1964672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6J9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="277" mass="31128" checksum="DD1C0B501CA2401B" modified="2024-05-29" version="1">MAVIKVHTKIKGKLKDRGRTVMFVGYADNSSGDTYKFYDPKTKRISSSRDVSWLNKSYGDWKGIKKTNTLRLTQEILLETVHDNDITQAPTTHTNDANTTVPEPGPIPTATAPAETATIPAVQLDSGANPQRVTRFGPTQQPATTAPIPRWQRDLRTWDTDRHGTQPILRTRTQTRLATANSESGRETATRVQTTEVPTEEEEIDFTGDQSGPLFNKNDVANMMMNPDLQRPDLLWKTKKRKTPTTKNQRTSKKHGTIQTNINGTNGEKRLERNFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6M4</accession>
    <name>A0AAD2G6M4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6M4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1963460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="183" mass="20000" checksum="AC1063C91E52A9A7" modified="2024-05-29" version="1">MKVTAAIEEVLTQFVGFHHDDEWMYGEAEERRLQQESSGGGTTIGGIIGPLIIIGIILYCCRGNISSCFPSEEEKLDKERRKIEARADVEAAKNRLENTKMETEISQFKRANNAAVAQNLAQGRLYQAQANTTAAEARVHASTQVANSMALGVVQNVGTAATVEPMEIISPADHKAKIVVEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6Z2</accession>
    <name>A0AAD2G6Z2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6Z2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49035" checksum="79981E3D961F8B29" modified="2024-05-29" version="1">MLRPATRSERKGLLTLDERESHGGEEEGWEDVLSEKHKKGASHEWSSCLQVTIVSFYIVAWVANGALMQGVTAGFAGDSSSYNKPAALSWFSYNFMMISGYVVSEVKRHGSLFGSSKRDQDMLMMDSEQSLWNYICEDWAGKLGIHRALLYCCLIAHMLLCLNVFTVMGLGCISISLSNAVYQLQTPITLAFSVGCLQQKRQWVPAEIIGLLISITGILAIVLPPVLKPDDEGSDESSSLAFRSSQCFVSSSNSTSTSPATAGVLITVASAIIGGAYLVFWDIFSEHKDLFRPTSRATEFLDTHITLAAIGFCNLVAGWPTLIALHWMGLESFELPSTAQTWGLLILNGLVEYTFDASCAMAIYATSPITVAVVAPLTIPLSMLVDEYFYGVSMVTTEHPWLTWLGALSILCGTTLLEVKPRLSCRQLSSRNNRDRSDRENQIEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7K3</accession>
    <name>A0AAD2G7K3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002214">
        <property type="protein sequence ID" value="CAJ1965713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7K3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="208" mass="23575" checksum="1438C95CD5063ED8" modified="2024-05-29" version="1">MLLEGDDWTGILQSYSQVEYETSIFVDRHVFLVSTPVAKGNSNCPSLVMDADFQSCRVNIRNFTLPRDIPRLSIGTFPLSEIAKAFHTAEAQAAADPDTMESFDIVMQNCGDFTSHMVTLLKVDFDHEMVQFIAKQLLETNRAFGRFVRTNPNVMNLLPNKKETTRLDELTDLQLLELLVESRAKHLYSPSTAPLSDRYEDSTMMSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7S0</accession>
    <name>A0AAD2G7S0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS21468</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7S0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="14">
        <location>
            <begin position="110"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="933"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="736"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="844"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="971"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="948"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1965880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1197" mass="136444" checksum="F11082C6598C8EF2" modified="2024-05-29" version="1">MSTNVLLKKKKNKPVFIGNSNLDSSTMVSQTAARPAAKREFPYVSSEDASPPKKRRGENSADGKENNGVDRPSVADDLAERQSEHRDSLLAGRHRNEQGKPPEAGVIREIYVENFMCHKKLRVQLCRNVNFIHGQNGSGKSAILAAIQICLGAGARRTHRARNLKDLVRKDSNCNAAKVQVTLLNRGDDAYQHELYGDAITVERTIAVRGGYNGYKLYNHDMEEISRNKKDLDEMLDKLNIQVENPCAILDQEDAKKFLTGKASDKYEFFMRATELERLDRKYAATLDMVRDLDNQSTRLNGALETYIEQANDAKKRHKEFQKIEELENKKETCEELYAWSLYNDAHEKLVEKREERDAFQAKAQKKIEELSQAEGAAQGPDEEETNRRNNLDRLTREADEQAGQKQNLEVDLKRASEPYKALSRRLKETRKDIGSAERSLASAKQQLESKRAEILARAGSAESEAAGRTKRLQDAEARLANAKEDRDRIRQAVSDSRKAYDELEPQVEQARHEVSAGEKRLMALNSRIRELEKSGNSSINIFGRRCGAVHDMVQKARFQGPVLGPIGAFVKIAPGKEMYAPLAELAIGSGMLDRFIVTNDNDRKILQGIRRKIGCQHDCGILQIHPHAKYSVQPPPVDGIDTVASVLQISNDLVYNSLVDYCKIEEKALSKSKKESEDLLLHRGNDGRLAVRGRIKTVFFLPKGDSWNVKNGTLGMSSNEKQLRQTIGVDKSKAIAETRNEMQAVQHEVNQHRREDNRLNHEHTESMKEWNKGKGQLRKVEKELDKARRDIESLQEDEIQASNFDTDTSEHEQLVTDEQATVDALKDNEVALIDQLQGLEPGIEELKSKLNETKARNERVMQDMTAAEEDLANYIQHLSQRQEKLEKKRNKVKQYEEIIEKKNIQINESDDQAKSYLLTAKTLAFHRQKKDSLDEAAADSEWSQEPTHADLEGIERPDQSQMKKDPKYYKTRLERLKERLQTERERRNAMNEDPIEAYEKYIRAQKLLESKMEQIKEIDETSKNLKSDWNKRKQRWRQFRQHIALTTDGKFNEILNDKGSSGTVEFNHKDATLNLCVQKDATDANSQQKDVKALSGGERSYTTIALLLALGESLETPFRVLDEFDVFLDPVTRKTVIDTLILMAKKMNHRQFIFITPQDVSNVDADPMLKIIKMTPPTRRDVAGAPIQQVLEFSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAT1</accession>
    <name>A0AAD2GAT1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAT1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="172" mass="20086" checksum="628059157DF7C365" modified="2024-05-29" version="1">MAMKCRIGIDFGETIGRVEDHADSAGAYPYSLEMIRHLVFQFGSDHVFIVSKAGPQMQQRISQWLKDATFFQKTNMKRSNLIFCRQYLDKVAIVEKLQISVFFDDNFKVVSSLSKLKQVKRIFWMHADTRQLKQIARGHRNKIAITHSWSNTMKYFQKIHPDKDANVKGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB08</accession>
    <name>A0AAD2GB08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF958">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WNK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="106"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1967803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="469" mass="52761" checksum="022A866947D82DEC" modified="2024-05-29" version="1">MNNTLIITHNQEAHHHHTSSASHSEYSSHSRDSDWLAPLPLVPTAAAAALIRKAQSSSYNTSLTSRYEEDDVTTVGSTANMSSSHFDTRLSLSALAELAPVSLTDFNIHQRLQEGSGFQVFKIQVNRSPTDDVDDMREYFSLKCLKNKSQSRESMEQEALNLKREAKMMQRLKHPNIVNAVGLSSHSSFGYFLAYDLIEETLEDRILAWKTGQPIKTPGGSRRKMNHHHHQNPQKKKPSKFGGGSQAHAPPLNERLYSCVLGVARAMMYLHARHIVNPLRPDCIGFSRNGTVKVFDFSVFDVDPSVQHLRYMSPEYILSNQASFASDVYSLGIILWQVATLKEPFGFMSKFKGKSNTKTRKTIAKKLANKRPEMRSIPDKDVKQLVKDCLENNPDARPSSTRVLFRLADCLPKEESHEQRLDRIEALLRSVEAKKGRSSGGGRDDDDDDDNDDDAGARFESAYDARITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBP2</accession>
    <name>A0AAD2GBP2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002423">
        <property type="protein sequence ID" value="CAJ1969027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1969027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="144" mass="16781" checksum="2A1F6C0C3A8EF583" modified="2024-05-29" version="1">MTITDFTVRKKSYRYLTTQASYPNHDSKVVLDAFDPTKDLQSQDLNSLVEKGVQGGAPAWYTGWPKEQVNNFNFWHRPMIRYTTVGKKKEQHFDKLYVLDHDVLENGSDPLAFSWPAKAFSKTDPVMQRRYSSRTVESYVPKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBY5</accession>
    <name>A0AAD2GBY5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBY5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="67" mass="7042" checksum="68E421EF6095E4DC" modified="2024-05-29" version="1">MPQLSALTANKNFLTGTNPPLPPSLSVCRLAEQSSGKHFCNRKGEGNCFSNAANAPSTCSLTSNQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCT5</accession>
    <name>A0AAD2GCT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS23946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 8"/>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCT5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1050:FF:000004">
        <property type="entry name" value="Trigger factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="entry name" value="Trigger factor ribosome-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="entry name" value="Trigger factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="TRIGGER FACTOR CHAPERONE AND PEPTIDYL-PROLYL CIS/TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560:SF3">
        <property type="entry name" value="TRIGGER FACTOR-LIKE PROTEIN TIG, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="Triger factor/SurA peptide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="Trigger factor ribosome-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042158425" description="peptidylprolyl isomerase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="215"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1969918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="523" mass="58037" checksum="7BC87DE9D0D4CD06" modified="2024-05-29" version="1">MKLRLFVLALLVSSTEAFVPQKVAFTRHLSLDASKLERLPESSVKVTLSIPGSSTKAAFDKVCNELSKTITLPGFRKGSKIPPAVLENAMAGKGGRYALRTQAIQELLGELIEPALKEDHGLEPIGQPTLEQDSEEVAKNFKPGEDLELDVLCDVWPDIEWKEIEGQEKPYFGLKGKYTRKPFNDEKFNKAINDLLERYAELAPITDKDHEMQMGDACIVNMEGWMANEAGEKGEKLPDAASGDNVEVILGTGRYMTGLVEGLVGAKVGETKEIKVTFPEALKDKTLAGKAAIFDVTVAEAKTRTLPELTDEFAEKVRAGLTVESLKEELRKAVDSEDSKEFRPARNAAIAKALAEVMDVEVPDTLVTKQAREKFAMMMTDMRNSGVPDEEIKNQIKPENFLKYKKIVKDDIVRDFKVSMATDEIGRMEGVEVPDYQVEEQMESIRQEAAESKEDFDETQIRSRVEATLQREAVMDLLAENSNFEVEFAGEEEFDAELMEKLAAESLAREQEAAGESAAIDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD53</accession>
    <name>A0AAD2GD53_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BspA family leucine-rich repeat surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002502">
        <property type="protein sequence ID" value="CAJ1970336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD53"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55820" checksum="449606E566971688" modified="2024-05-29" version="1">MQEVQENSNTQGSTVGNNVRRSSKRRQVRMALLCCFLILAAAAGAVVAVLKMKDSEEIIDTSSNNKTTTNVTSPAPTELFSSNPTHRPSLPGSRTTSAPTPNPSPGPTYRPSTSEPSRSPTSSPTRPCFQTNTELSDAARDWLQDSQIKTIVENQYGSIGDWCFGPSVTSMESLFRSQSTFNEDLSSWDVSSVTNMADMFNGASLFNQDLSSWNVSSVIYMSGMFWSAASFNQDLSSWDVSSVADMSYMFDSASSFNHDLSSWDVASVTSMRWMFYIASSFNQDLSLWDVSAVTDMNGMFYRASLFNQDISSWDVSSVTDMGNLFHLASSFNQDLSSWDVASVTDTSFMFHSASSFNQDLSSWDVSAVTDMSSMFYQASLFNQDLSSWDVSSVEYMNAMFYEASSFNQDLSSWDVASVLYMNQMFKAASSFNQDISSWNVSFTISMNGMFEGAELFNQNLCPWGERTMIPSVTLNTFETFLGTNCPSQSDPNLSSNPPGPFCHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GEK6</accession>
    <name>A0AAD2GEK6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002514">
        <property type="protein sequence ID" value="CAJ1970431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GEK6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="346" mass="39811" checksum="FC63D1AE09147CB2" modified="2024-05-29" version="1">MYLFDTSNHIRKPYNTEIGIHANCLKTLFMYHDMLPGNCSNVNNENDPGQIRKRKLALFRSFPIDWQGDFINSRNDPANDDNITWKDIVSWMTQKKRTVDRKRLMQESSPRQTRPGNRTGGRGLHHNRFRGGCGHGRPSNGYQPYPRPSSSPRYSQGTSQNFQRGGNSQQQNQGRFQPRHPNNGGRGRGFNGQHSGRSQPIPSNKTKDDFTQDTPTMVAEAVDSMASAVDAPNLVVFSQDETIKAETNHINKTVKTSMLSRTNQEAESFAAECSVPEWNQDGMSYGGMPSAKQYQHQEQYYQAGENQQWNDQYNYEQEEYYPEEQEAHEHFSYDEDSPFSFQEEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGA6</accession>
    <name>A0AAD2JGA6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiaminase-2/PQQC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19358">
        <property type="entry name" value="TenA_E_Spr0628-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026285">
        <property type="entry name" value="TenA_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050967">
        <property type="entry name" value="Thiamine_Salvage_TenA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43198">
        <property type="entry name" value="BIFUNCTIONAL TH2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43198:SF2">
        <property type="entry name" value="SI:CH1073-67J19.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003170">
        <property type="entry name" value="Pet18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="3">
        <location>
            <begin position="14"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR003170-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003170-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="216" mass="24911" checksum="C1825B2C42D91B71" modified="2024-05-29" version="1">MRYTDQLREAAGDQWNRVIHHKFTKDLAAGTIDHDSLKKYLIQDHRFLDSFVVLLASIIAKAKTLEDRIPGCQFLALITGKENTYFERSFEALKVSQEERSSIPNAACTTGFCDLMRSVAATGSLAEMLAVIVVCEWSYLSWGELVLEEHVRKDFYCYEWVDLHSGDYFTSVVEYLRSLLDKEVETMNDAEKEACQARFLETVQLEEDFFDFAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGH4</accession>
    <name>A0AAD2JGH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26720" checksum="BCADA15B74B95D14" modified="2024-05-29" version="1">MSASSLPRSPSPAFCETTTEKDDDPQDPSTTDQVVSSQPSPPSPPSEEAEPYEELHSSIHHGNNSKCRNLTRALWQSSALIAYTWFVCTVAVVITALISPPHHLALLVYSGLSMLLATLMMVVEVYREDFYGIHPVSPKIIPMLWNPRFGNCCNFWIYCSMVPPALTMTVMKLEISVLLFVVLNLLRLCIVFRNHWCHVTDVDDDSTSIPETIRISIEPTAEDSLREPLLASDDTSADNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGI1</accession>
    <name>A0AAD2JGI1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001737">
        <property type="protein sequence ID" value="CAJ1948026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="28790" checksum="20602EAFBFB25D45" modified="2024-05-29" version="1">MAAAIPVFTIYDAMILCQIPDTGNFQGQTDAQRMAEELFDNDFGTAMTKSIKQVNMDLATLASLTAVQGRIAFVQWVRDEIRMGRNPAQHPFPAGDTSTLLQRLNFHQKYVKDSKTLIDNTVPPKWSKEQQWKQWVKLLRDHLRAYIGVNGIPLVYVVRENAAQDPTPQDDFLDKYINMALLVGTAFIVDNKQVLALLNKFIMGCSEAEMVIQALNTTTDGRAAFFALKAFYEGEGIFAHDVMAAVLSINHQTRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH51</accession>
    <name>A0AAD2JH51_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH51"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="48105" checksum="7C2B84716E376682" modified="2024-05-29" version="1">MCKPTIETKESIHTTNSDAATSHHRGFLYGTISLAFAITANSVTMGHMQSRRDALGCDSLCIGSMTSARSTLTLVGSTIVGRLSDSKALDRLGGARKFCLLIGIFASAAELLIASQASTMSTFWMSLVPAALLNQNFTVLKALFGDYHGESAGSAERAGSVGKLGMAAGLAFMIGPLASSKLLSTYEQAAACAAFCLLVAALFIFLLPTPKEHSSSKPNQNGESDKNSEASTAPKKWWSKIVPDFVPAARTPPALFIMSARVCMTLAFHIFQTIWTVALKERFNFGPKEYGQYFGFIGFAYAISQGFLAKFLIQKFASTNKGRARILLVCSLVLGGGRMFAYQTNSIVAVYAIFCGIITALGIVNTIFTADTSKIASPQELGGLFGVLSSVESMAGIAGPMIGGALSKVHPQQGPLMAVMTLYGIVFTLVYWGYERYVGVHNDEASKKKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH58</accession>
    <name>A0AAD2JH58_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1949047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="220" mass="23779" checksum="DCA4889BD2A9DFBC" modified="2024-05-29" version="1">MVEAHVLLLRIASTLSQLLTSMYFLIGTTIILDLYGGSTCSTPQNCLDHVPIAHRIASTLSQLLTSMYFLIGTTIILDLYGGSTCSTPQNCLDHVPIAHRIASTLSQLLTSMYFLIGTTIILDLYGGSTCSTPQNCLDPVPIAHQIASTLSQLLTSMYFLIGTTIILDLYGGSTCSTPQNCLDHVPIAHRIATAMSQLLTSMYSLIGTIIILDPYGESTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIA2</accession>
    <name>A0AAD2JIA2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIA2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8699" checksum="9A8FF886ECDEB5B0" modified="2024-05-29" version="1">MPSDKPTTAPETKDTAEKTAIEAIEEDDEFEEFEPANWSAGDEAAEDTQQWQDNWDVDDMDDDFTKNLRAELTRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ26</accession>
    <name>A0AAD2JJ26_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS15426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ26"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042186499" description="Peptidase S1 domain-containing protein" evidence="4">
        <location>
            <begin position="31"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="55"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1954834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1102" mass="120792" checksum="B69F873E53A2F9F1" modified="2024-05-29" version="1">MGEQSLQSKPYNMLLPCCFLLLLLPQLAQAKPQKTSQTDGSNHFPSSKRILQPRIIGGTDAEQGQYPYMVSVVANSGAHDCGGVLVAKDVVLTSAHCSGNLARVHVGRWNRRFQFLGDQFDDIAIRKEYLHPLFEGETDSENLNYDFNLLKLDGFSALQPIRLNEQFFVPNTNQAVTAVGFGQTLPDDGSSEATILQQVELKYIPNEECSLSSDGLDSYEGLLSEAMMCAADEGKDACFGDSGGPLVARNLDSEPVDNDPSRTTDVLVGLTSWGFGCADTNFPGVYARISNQIGWLKETICQISDDPPNEYYNCPTFAKDGNVPVVVKLTLDNYPSETSWQISCNNVVYGQAAEGKYGNRPGEELEEKVFVPSGSSCTFQMKDKFGDGLCCDSPGSFQLYLYNDPSQVFASGGGNYGPEASYGFNIPSDADTGDMDPIIGDGTIPLTVSLLFDDFPEEVGWQVDRIGIGATTVYNFPPGTYRMPNGRAIQTVMLQDNQIYRFRITDFQRDGMPGGTIQVLLGTMDVNERDKAILERRGGDMKESFEVTFTSWENSNQATEAPAVGSGESFLTIALGFDLYPQEIGWQLRVRDRSLIDFSRSEEEDGEIVAFRPIGYYSDRARETVFDQVAIPQLPLNGERDFIFIITDDHGDGMCCDWGNELVEPGYSIYEGDASAQNLILSSKMKDTSREIKYFDLPSERKQPASTNAPTQDSVETSAVNLEISLAFSERGGSSSFYIEDSTTGNRVVNYPCSPNIGTTRTYSIPSGVYTFAISNDCGKVGSVSSEMEYAVRLQGAGDNRPPLLQGTKPGIDTFVVWGEEAQVETMEMSLEFTTNSDPSSFNHYIKRLDVEEDDAFLAQVSKFSLEPNRYYMQSLSISKGGLYRVALQGVTESALVNSQVMLKIGDKSYPITFPGLRPSEEQYIKFLAGSLPSVSTDGPSLMLRIVYDNDPLDLEYVLFEETGNGEDTATSRAVSGRKMRRNRVYAFGPQNETLVSSLAGQEHIEILPLPSYAGEKTFTLLLSDSGGDGLCCKQGNGGPIELFDGPIEDDKLLFQDAFSGTTRKAFTFTRQGEAQPSSSSRCAPFSVGLGVSFALAALWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKB9</accession>
    <name>A0AAD2JKB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS16899</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKB9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042047487" description="tryptophan--tRNA ligase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1957835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="418" mass="47034" checksum="29CEE78B957FE601" modified="2024-05-29" version="1">MKISLPQSMLVLSTILGRTSAFVKPAYNPARQSAFLRMASTSTEVATEQPPKPKNIRAERILSGVQPTGSLHLGNYLGAIRQWVDFQNKEQTDEEGNVVPVENFFCVVDLHAITMPHDPMELQESTLSSAALYLAAGIDPVKSKVFIQSHVPAHSELTWLLNCITPMNWLERMIQFKEKSKKQGESVGVGLLDYPVLMAADIILYQSTKVPVGEDQRQHLEITRDIVRRFNDLFCKGNKYKKRCKAAGVASRPVFIEPNPIIMKEGARVMSLTDGTNKMSKSDANDNSRINVLDPPETIRNKIKRCKTDDIQGIEWDNPERPEAKNLLNIYSAVQPDRTKEDIIEEVKDLTWGDFKPLLADAIINHLEPIQNRYHEIREDKDRLNEILKEGADAANTVAKQTLFNTKVAMGFVTPDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKD0</accession>
    <name>A0AAD2JKD0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001991">
        <property type="protein sequence ID" value="CAJ1959300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="131" mass="15141" checksum="8AC11A281A38EF32" modified="2024-05-29" version="1">MEQGYLEEVFDQDYEPEDEDERDFNLRGQFDDIDDSEREELLADADNDVDDMPELTVRFQGDDDYESDEDLGDEGDEEEEPIVADLNHHQENVDRGTDDIGSLVTDLEDLQEPPKEEIVFEPEEPQVAKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL35</accession>
    <name>A0AAD2JL35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS18660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL35"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1960296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="403" mass="44103" checksum="A6BF47FFAC58768A" modified="2024-05-29" version="1">MPPTAKAPKDGIEFDSLPWNLNLPEEHSYIHLTTESGEWTTEHYDPSTDKGLLFDAVKKYSETTLPLTPSTTSLNYGTTIWEGLKCYRTKEGKCIVFRPDKNFVRFTNGADQMCLPKPSKELFLRGVQHVVQENSHLIPPCGEGMKLYIRPMMLGSGQQLGLYPSPQFSLLFYVSPTGNYFKNATGGLNIHLETRRSRASRGGLGSTKCAGNYAIALKPLLDAKKEGFLDNLFLELETYNKGALEDAVLQEMSAANVFFVLKTGEIVTPSLDRGTILPGVTRDSVITLVQDFADELKEAMKASTGQESVTVSSRDVTVGELRNATEAFATGTAAELVPIARLATGSEEESFDVTFPHGTELPGGPVTSALLALLRKVMVGEKSSEGTKGWLRDPFASPEEFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLJ9</accession>
    <name>A0AAD2JLJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041918678" description="Beta-lactamase-related domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="124"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="745" mass="83015" checksum="6790134FD3B7FD1A" modified="2024-05-29" version="1">MRYCNPLLTLAALLLLICNPIQSSSSVLAAATTTTFGVCEPDSSSSSLETSCAKPPALTLENIAEFMDETIPKQMEESHIVGTTLSVVKLSSHGDHDDASLGSWLYGRVFGGEHEGYDDDDFWQYSKGYGMANVESNIGVDPDSSLFRPGSISKMFLWTAVMQLVEQGKIDLDQDICTHLKCEEIPTLTKKNNPKDYAPITMSHLITHTPGFEDYLFNLMVKEEAKLMSLEECISFRTLQRVREPGAELAYSNYGSLLAARIIEVISGLTFEEYIEKNIFEPLGMADSTFRQPLPEDLAAGMAEGYAYNGEGTVKKHFELVNGTPAGGLTSTANDMAKFMKAHLSVNSGGNGLLKPATMKKMHTLLYQPDPQYEMGFAHGLMDMSTNGVRVIGHGGDTLYFHSLLALLPEHKLGVFFSFNTGIENGLPDFPADKIAKSFMDHFFPAPTGKEKRAMMMMKDHNDDSDANITTTTEPHFALDYTGSYNSNRRSESDMLKVNSLAMSYDVKRGKTPGSILVSSFIQPEYTEYVEIDEHLFQEADGQHKLLFLVDEMEDGTRIVRSIFADALPVLQFTKCAWWEQKRFNICIAATGQISILLGFFIWFVVPFLRYIWSKAAALRRGKGAATDDLQQQEETPSMGPPGAKFASRLGSAVVMAYFAFYGSIIYISVVRDLVFGGSLPKWPFFLPYIAFLLGLPLPVMAVAAWRKKYWGVAFRIYYTVFAFAVQGLFWFLWHWGFVAQSLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMW3</accession>
    <name>A0AAD2JMW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M11 gametolysin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMW3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008752">
        <property type="entry name" value="Peptidase_M11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05548">
        <property type="entry name" value="Peptidase_M11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041951804" description="Peptidase M11 gametolysin domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M11 gametolysin" evidence="3">
        <location>
            <begin position="360"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1157" mass="120451" checksum="200BCA5D895EA5C8" modified="2024-05-29" version="1">MTSSMMIAKMLLRSFLLLQVLQTIVLAQRTEIFPPGLESNFAPGLQQVSLDQQNLPCTLYDNVVEFADGTGTSEWTCEVFGQDAKNAGSSKKFSTARVEGMEHVLAANPNIQSGKTTLLARGAALSDYKLTIDPGIPLTFGEVDPTANRRRRRLAATSGALEVLVVRVSTKDSVLPQSKAELSGDVFGTLGTGDTLNLKSMVEECSANELRVNPGTGTGSYCAENPDAVFDVPRSDLDTVYNCEWFTKFRFATEGDFCPVYGDAGQTFPTVDDSKTAKTECCICGGGTTVNYDNNVEDGVIDLLVPFFGYGATYKQVETAALEALEDLFGVDRLDERFDNVMLCLPYGSFSPNDTTNRDWIAYAGIGGYRSVYNSVACSNEVTQMHEIGHNFGLRHAWDGGVEYADETGAMGFTSGAQDDDPFGNRKCFNGAHSWQLGWYTPFNVEFDPLTTNFSGNLVGVDRVPNVVNGCENVVLKLSHPIEDYYIIYNHAVGANEGTKEYQNLVTVTSMPSTTTPYTYLKATLGEGAVYTIPNWANSGQSVTITVTSIDTDAATGSAVVEVWKGGLGDRPPPQASACAPGPAPVFDPTSGPTSGPTPVPTSGPTNVPTIEPTPVPTSGPTSGPTPVPTSGPTSAPTSGPTPVPTAGPTSGPTSGPSLAPNPEPTSGPTSGPTPAPSPGPTSGPSSGPTPVPTSGPTSGPTSGPTSAPTSGPTPVPTTGPTSAPTATPNAEPTTSGPTSGPTLNPTSRPTSGPSSGPTSGPSSGSTPQPTSGPTSEPTSGPTSGPTSGPSSGPTSAPTSGPTSGPSSVPTSGPSSGSTPQPTSGPTSGPTSGPTSGPTSGPTSGPTSGPSSGPTSAPTSEPTIGPTSGPTSGPTAGPVLSPVAPSVASPVLSPVASPVANDDEPETEVTGDPHFKTWKNEHFEFHGQCDIVMISDKDFANGLGIDIHIRTKIVRFWSYIEKAVIRIGNDILEIEGLPDFSASYWINYEHMGELSDLSGFPVSLNDNTDRYTIDLGSLYPGEKIVIKTFKEFVGVKILGGSETSFGKSIGITGDFKTGNTYARDGSTVLNDFTELGNEWQVLPSDGHFFHTLSRPQFPEKCMVPENPQGERKRRLGESTVSEEQAEAACAGLEDEFSRKGCEYDILATQDLEMVGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNC8</accession>
    <name>A0AAD2JNC8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002303">
        <property type="protein sequence ID" value="CAJ1966626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNC8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="208" mass="23862" checksum="9F209D2140CA2604" modified="2024-05-29" version="1">MGQALSIISHTHTYVSGLLHFTLGRGRWSQYLIEDCTFSRLQIKDSDSSDEALFKQHARIHLFSLASNFYLYNRPHYRKGSYRDDLVDNLRNVAIPGTGIPLSTFVRSRVVAFGFLLTAYPAISFFASTQKWIKSKFQSSLSEEYATRLLAPDDWFSFWRLNCNIVGLHSLLNKMPSGYATENKWTFLESGSEKNVPSYYTEQSIDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JND4</accession>
    <name>A0AAD2JND4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JND4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="166"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="426" mass="47678" checksum="0C21F1221E87479B" modified="2024-05-29" version="1">MRSTIAGFRRRLSSPTILASSSAIGVACMGGWLYEERTEVGDRFPSSIAQCDGDSGMAHQQPQQQRQRQQQQLKGSPNDANREHVKMIFLGSGSSTGCPKPLCPMVFPPSSTSSSKKPINKDQEHLWNHCQVSNLAIRGDPKTNKNYRNNPCFLIQSFDSEAQKMRNVVIDVGKTFRETTLRWFPIHNIQSLDAIVITHHHMDAAGGADDLRNFQLVDQDVYQKTGQLVRLPTPVYVSHFCWTNLKTVFPWLFPSATEVLPKQDASQPKVKRDVASLDVRLFKDFQGFEVVPGLTIVPLPVLHGDDLVSHGFSFSVQNQKGEFTNVVYLSDISKMIPETMEYIQKQLPPTDILVVDALLLKGTNPVHFNLDQAMALRDEIQPRGQTYLVGMSCDSFPPHDETNAYLKEKYGAVQLAHDGLAIDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNF9</accession>
    <name>A0AAD2JNF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxisomal membrane protein MPV17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS22031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1966448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29584" checksum="874701AF5B5EA32F" modified="2024-05-29" version="1">MEGNNTNSGIVIDEESLLLFRQQVNDDEKYYALYSQDSYLSSTAATDTVSASSIDEEEKYDTVVDNHNDGCLKRLWEAYYGALLTYPLLVKSLTAFVLLGFADVIAQCFERIRDSHNNSSAEEAFNLYRVARFGFFGLAGAPWTHYYYGWLDTVLPPTQNPWTWTTAIKVVIDQFLQAPALLAVMIMGMALMEGRGISGVTVDMENQYVEALIKNWELWIPATVVNIAFVKPDLRVLYDNLVFFFWTIFLSMLLNQAPDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNX7</accession>
    <name>A0AAD2JNX7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002351">
        <property type="protein sequence ID" value="CAJ1967899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNX7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="116" mass="12588" checksum="C72DA7AAC7BE48D3" modified="2024-05-29" version="1">MGHSSSGGGKGRVTPQKVKSNSSSTVVKHLFSTKDENDGKARSSYKDAKERVIDYIQASGMKCSEDMVKSIQDGKSIDFNAIAPTLNAPTQTEAVARETEMAQNKILYSAKLDEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP75</accession>
    <name>A0AAD2JP75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045000">
        <property type="entry name" value="TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42898:SF6">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42898">
        <property type="entry name" value="TROPINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="272" mass="28986" checksum="72D817A77B411E6A" modified="2024-05-29" version="1">MASEREQIQKGWTLQSRNYVVTGGSNGIGLATVKALCATGAAGVLFCSRSPCDELLKELQTSYPDSNLYHTAVDVATSDGRQSLVDEAKTVFGGKPIDGLINNVGINIRKPFVEQTPEEFHSMMRTNVDSAYFLCQSFSSLLQSGSTIVNVSSAAGVQSSGTGAAYGMSKAAINQMTKILACEWAARNIRVNAVTPWMTMTPMLKEAVKANPTQLDKVQEWTPMHRLADPSEVANPIVFLCLPASSYITGQVLGVDGGLTAQGFDGPCVTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPE8</accession>
    <name>A0AAD2JPE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS23752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1969522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="483" mass="54841" checksum="565957F572857421" modified="2024-05-29" version="1">MSDTVNSLASTVLMSNEKQNKGATMKAATSGAEKMPLNGSIKTTMRNHTSISDNSSQEMAEDEGSLEFQKPGWWDLYKQLLRRYRIPLELAEEALERILFWMPHSESEDPNDPTAPKHQWREVLFGLLSLHRLSMYCASEETEGSTMGLENSYGMTIQTKEQPTISATRIRIYLSILHCLMPTLLEILPSNKNSRRNPSARQHSQSRVRLRLEQVKFGLRLYLLASYWTQQQWQQSKEGESWLDKLKGNAFNIGILQAGGMFDVVGQGSGLHSLEAERMGRRKAYMGRRTGLTIRLANGSGKILPPSLSSTTNIRASVSAEANGHESCLHNDSRQRKGHLIGILIGELLHILRPLYWASAEAYGGSETTSLSLPGIQQSSSSSLKMLKPWIETLLMDLVSLKLLWRHSTKNSGNPWTYDEWKRRKGRMLLYLLRGPIWSKMTHPVLEKGSAIWTKIPILGRLLDVFLWDWILYWKLPYIAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUK0</accession>
    <name>A0AAD2PUK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS12799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUK0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="MJ1316 RNA cyclic group end recognition" evidence="7">
        <location>
            <begin position="181"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="438"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1950870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62084" checksum="63AA8626B8BBD00D" modified="2024-05-29" version="1">MFPKGSCLAFQKHIGSATRQIRRNAIQRQQQQQQQQNRHNGFLPTFASPSLLLKRVPHPPAGTTTTSWQLHQSFTTTNDGDSGENSTQNPISLNMENLYREWTLEQDKLLWENKDSKSIIELASLLGRGLNGVQARLSKLQDLSSPAYERLFVTGRNGKNYSNKNGDDSADNDSTGKQKLVPAGEVLRRIEYDYRLQEESSNFFVLHYDRVDDVVVESPLNAPNDSIQGSATMLVNALPEHRIVGIKYKERIVWDRAERLDLVFSNGDEGGGIYHIIDTYGDWKAEQDRVVEWNRQRQKFIAQRIQHILGAEHYKSLQQQSSDIKKAFGDDTISIKSMVEAYVQSVLSIFRSRRRECESSDTPTTGGEMQGEEPFDIPQTDFEALEEFSELVAVLPDPDLRSLLLTEISLVMDRLEGKGSKKNGGTAGAGRREPLVLLEEELSERFVRGSGAGGQKINKTSNRVVLVHEPTQLKVECQDTRSLSQNRKIARKRLLEKLDEHFHGKQSKIGWKNQKAVQKRQKSKTKNRARQRKKQLEKQDENGDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVE1</accession>
    <name>A0AAD2PVE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197">
        <property type="entry name" value="PROTEIN ABHD14B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22342" checksum="6502818D125AEBB8" modified="2024-05-29" version="1">MGDIIYSVYGETRHVPYYHCASNFSPDQSHHLVLLHGARFTKEDWKSSGIFETLCSNPHVSVSAMDLSIEAGHRDIAGMLSAMKEEAQINLPVTLITPSASGMGIVDWMSNGRLPDLPKYVQKWIPVACFAVSAATEDQLARLSRLEHFDVLAIFGSKDRGGRDISTRLEDYVGARSLELDGGHACYLDSPHEFSSAVLKFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWD0</accession>
    <name>A0AAD2PWD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000006">
        <property type="entry name" value="Putative n-alpha-acetyltransferase 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="166" mass="19285" checksum="630E31C9C1EC4E8E" modified="2024-05-29" version="1">MGKQLEVEFGQITDDNIEQLRQVNLACFPVQYQETYYKNVVKGKNEDLCKFAYWNGYIVGAACSRVENVEGSDRKRLYIMTLCVLAAYRGRGIGTQLIQSILDHYEAEKDAALSKVDEIALHVQISNEDAMNFYKTKFGFEKGELVENYYRRIDPPHCYLLYKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXH8</accession>
    <name>A0AAD2PXH8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002286">
        <property type="protein sequence ID" value="CAJ1966429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXH8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="17599" checksum="663545909FA004CF" modified="2024-05-29" version="1">MVANVTLTLLAWMMLILTDYSILSVSHMMLTVTLNLMYFAVRLVPYRCNVFDTSEQLALQNNNRPLTFDEYASLLEAAAQNHDEVTKGSKPKANPRKAYATDVVTTGDLEPDPGPPMFDFNIDMDLGNYYAYRTSLSSACKTFLPNELWQQLDDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXR6</accession>
    <name>A0AAD2PXR6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="301" mass="33582" checksum="AAA42700EA5596E9" modified="2024-05-29" version="1">MPEEEEANSSVGPARSSSDTVTTIHSFSSIPVEDDHFSYVSGITMDDALAASDRLTLSDRHQYRLDPRLHSLRELERASDQAMGKCFDESLRFSDRTNETLRLSDRTNESRFSGASEGACTQLCPLPRRRLSMSYRSAYSRSSSSNLEHLHGSLDSTYSDHQESAYCNLSRSSSVDSCLSQQTSCSGDVDYRTSETWNHSSCFLSEDKLDLSQHFDENDESHSSFEESLHGGVLDGPEYELPLGGEDESRLPISHEDTAPRRNYHRKGKSAPSAYGYSRTGVSSQSLDLLDVFGDRCTRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CB44</accession>
    <name>A0AAD2CB44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1913767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CB44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="2">
        <location>
            <begin position="288"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1913767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="821" mass="90637" checksum="F130287DFFF2E10C" modified="2024-05-29" version="1">MATTPRKSSSTHVSYESYAPRSTAQVSRLSRIAALTAGPTAMAFYEESKTEDSSSSLLKAMSPPPPSASLTNNALVQDPSVKETMKRATHEADHLTSLLKHTTSLKLALRASINIAEDISNRHADLIRHSGELSAAADRLQGEQAVLVKHAEEIGMPLKHYDAVDSIGVLVGVLFKGKTVVRGLAKIKVDNDEFPTILDKIDDAANFFGRECGGKEVLEAELKKQKKSSNAQISGNIEYYRRSLALQEAALYLIREAVVDRISTTATQVASALNIPKVPIAADKLEASLIYTRYHGISSRSNRLLALVRKRLHHGDAYHELLQLCRTTYCSSRESLLRATIRNHMDKLKDQHGLVGMTRLAAVFLIRLCTVETALYLDFFGEKKSDTKEEEGSKTTGEGTAGGSKTLASQVVSDDGSYYDSEFQSYLSNLCSALHRTVRRGVVTVLDLDTLCQIVSVLREERSMASSSPTTVAAARAISSVIEDAQERLIFCATNALTREVIRFKATPADLDYPDKLKAKPEEEAKEGEPMEDAVQKQLQVYESWFPPMRSVLKILSKIFRVVEPRVFEDIALQSVQSCTKCLKDGAIYIQKRKGALDADLFLVKHLLTLREQLSPFDIDLRSVERQLDFSDAGRAVSRFLANRNRRLFSMTTENALVTLLREGVSINEESVDSKRDLEEALRQACNDFIEHTCISMASDVLGIVGQQLELSNEALVDAKFFEANKIKAALTKTSELVDAKGGEMTTQMKLYLDNPATQSILLKPIARKITKSLDGMRKGVDIAMDGTNGWDSEIRAEIITLIGEVEEKVKACVKAIPNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEY4</accession>
    <name>A0AAD2CEY4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">60S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS2970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEY4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="5">
        <location>
            <begin position="73"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1932705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17495" checksum="A467E417EC914213" modified="2024-05-29" version="1">MGPPPSDDVKIVIMRTVGGEVGSASSLAPKLGPLGLSPKKVGEDIQKATLDWKGLNVTVKLTVVNRQATVSMIPAASSLVMKALNEPVRDRKKVKNVKHDGNITLDQVIDIAKTMRERSNAKKLAGTVKEILGTCNSIGCTVNGESPRDIQSQIDDGEVEIPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGE4</accession>
    <name>A0AAD2CGE4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000187">
        <property type="protein sequence ID" value="CAJ1931869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGE4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="124" mass="14340" checksum="437E41A909A5D10F" modified="2024-05-29" version="1">MKVIINGATFNQNPKHNSPIPLYKEVSRWDPESKAKIKLKMRHSPQNATPNYDKEFTPWDGDTVEDYCQFRFTWNEIKIGQNLNAAQKHQVIQSAISGQATENLIELSEDSQKFFLCQPDMLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH36</accession>
    <name>A0AAD2CH36_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000336">
        <property type="protein sequence ID" value="CAJ1934554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="185" mass="20698" checksum="5F4CB51F861545C9" modified="2024-05-29" version="1">MIQDGKSINFDSITPELDALDQTEVVATETEMTQNKIIYSAELTNHMNRAAYFETNKVQIKVKVNQRMKRKWQHVMYVATRTICPTNVQTDCYQRFKSSIPPQGKLRSRLVQISANLLEAAEVDPTPEPVDFVIHVENPNSNQSASIAISPSMDICGATALSTPTDTPNDNNLDQLKLSSENNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHC9</accession>
    <name>A0AAD2CHC9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHC9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="160"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="232"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="305" mass="35035" checksum="FD397841C5A792A7" modified="2024-05-29" version="1">MFTLPKTVFSFHNDISTDDTCIMDDTPLPFNDMIPAGNIYSTFAASTSKLQFHAYPTEPCTSILEPAPIGPKGVAAVPSFPLHEVILSSDISQVDALKQLFLGGVDALTRDYQPTSPSSPVPLLERSGSTCSMSSVASSRKTPAKHCTGEKLRYGNRQMAQWHKRFQELVVFRVHHGHCVVPMQGYESPELSNWVKRQRCQYRRKMEGKSHTLCDRRQKALEDLGFVWDFRSTSWNERYQELCQFWNEHGHSKVPKSYKKDPVLAVWVKCQRRQYRQSCISKERIRLLKNLDFDFSPRKHLNAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHP0</accession>
    <name>A0AAD2CHP0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000413">
        <property type="protein sequence ID" value="CAJ1934917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="16709" checksum="53ECEFC03B57A078" modified="2024-05-29" version="1">MTWDQSQHLAISEYERDVELDQQVEKDDNEWIEKLLAAEQASSKFEGTITIDLVMPAAKDINNGATVGSATNMAALLENMKAVVNDLWTELETAAEELAQAKDAEAAKDARILEFEAKMAEQALITGKHRLSSPSSSKATSPADSGGGPVTQGCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI17</accession>
    <name>A0AAD2CI17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS3407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000291">
        <property type="protein sequence ID" value="CAJ1933668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041912508" description="Sulfatase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="40"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="76"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="210"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="611"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1933668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="711" mass="78535" checksum="F268879825F2B511" modified="2024-05-29" version="1">MSKPQHQVSSSPTTRQTSHHSRIILLIVTLFLYIGESCGREDDQPKIKSSGTRSTTTKKITETKTKTKNKKKPSRPHIWMIVVDDLGSNDLGFHGSGIHTPNIDSLVMGDDNKDGYNSSSSSSSILLDQYYVLPCCSPTRASLLSGKYPLHHGIHSYIEDYSTVGLPLDNVETLPNMLKRSKADDGGGGGGGSGGGGGENNKNQEGGAADDGYETHAVGKWHLGHAKWEYTPTFRGFDSFFGFYRGGEDYYTHSAKNAYDMRYDKQPMCGRNCSKIVDRSGNQRDEKNAGTRDELGFGKEQYSTHVFTKQAIRVVEDYGNRKHTLQDHDERHPSNETDPTESKNGTLPPLFLYLAFQAVHAPDQVPWPYKDRYSDRADWSDTRKTYAGMLTAADEGIGNITKVLQKDYPDIWDNLLIVFTTDNGGPTEICAVQGSSNHPKRGGKCTVWEGGTTGDGFVSGPYMTKLLEDENEGEVGNSNRDKTTSLSDAESSKGQSHDSTPVHSMRHYSHLFHVVDWLPTLAQIVGVKPRDGLDGKGQLSGWQHDIPIRDHVHIGYAFAAFSTKQWYGPAIRSQQWKLIQGSSGGPDENNLKPKGSDEPLPGGGSIDGGQSESASVNNNNNNNTSFENESNYLLFDLENDPNEQHNVASQFPEIVESLVDKLREYQKTYLPPQPEDPSCPFTGFVNTSMGPTWYDAMVQRGCALFVKELHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI36</accession>
    <name>A0AAD2CI36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="138"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="311" mass="35871" checksum="6675E1594867762A" modified="2024-05-29" version="1">MPSSWIWMKGITPTIPTQVMDPVGDDDQRPSVLDLIAEHDTNIQELASLVQEDPLYEPEKHDAIFLLRFLLSHKQNVKRASKAVKATLVFRKEYRLDERDIRHLVPHKIQDGEYGEMPFAKTDNLQNAWKTRSPEDAIVFTIPDPKRGVVAFLNIGNLKNDSKTAKKLTVDDVASVFILTSEWAHQWLDYVTRTTGRFTKSVRLIDFSNFSIFQNSREATKRDGKIMDMMEDIYPQLLQALFIYNAPNWIHSAWAIFRPIMPKRIIAKIDIIDPKNNQKEKEKLLAFLSDENMPVTMGGSNTTSPRDWESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK58</accession>
    <name>A0AAD2CK58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">A20-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS4555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1935219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="144" mass="15623" checksum="780366E9F26EDD20" modified="2024-05-29" version="1">MSANHEDNSTAQAPKGPVLCKMGCGFFGSDATGDCCSKCFMDSLKKKSDKCLPVSRTPASPLPTPVESETEQEPEHEPEPQPQAMEVDTPAPMPIKKKKKKKQSYKNMMKAMTSGDTSRDVKQEQREKIGTGVGGGAFSKIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKY2</accession>
    <name>A0AAD2CKY2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS5921</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKY2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="357"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="90"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1937994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="621" mass="69837" checksum="1DB4157F32897421" modified="2024-05-29" version="1">MMSHRFYSHAHFQSQLLRHKQHLPLLAVLAATSIGQQQYPEVVPRLSARYASSEASKDDKDKKVDKGVTRFDITKRWDDVKSDWEALLQTSSSSKTEDDSQDTSPPSSGASSMFDKLKGAMDQAKGAMDQAMDKSEKGTTKTPSDQDNLKEMGSNLMNLVQLKWGSKMTGGSSATAQANTVQDIIMKARDMEEQGDVKDSISLRELLEIAQMSNKKLESNLTEFFQEESKKTGNVFTRKDLPALKPPDIYYYLEKEDQDKNPSVRRRKHRFFKGVDVNQIDELNEQLELALLAYADTMKEIQVTLQRDYDCELAYCDMESTPGRPSHFIAVNKNSVEKKQSALSFLSSDSSTLEVIMVVRGTKTITDIITDLLMDEEEYKGGHCHNGILESGQYLAGKHTTLFRNLLQASGKKKIKLTLIGHSLGAGAATIAGMELNELPEMDVQVIGFGCPALLSKELSQKTESFVTTVVADNDCIPRMSSATMLNAILDIASFDWTAYAKQDIADAVNEVSSYFPTLLKDYKQTILETAHSLPVREMPARIPAQRLEPILYPPGKCIHLYRDGFGISGNVVPCTFFSELDINRRMLHDHTVDMGYQLIFLDLMRQHHEDHHFQFQKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM68</accession>
    <name>A0AAD2CM68_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS6540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM68"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="84"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1939325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="418" mass="46359" checksum="AEFC13F0DB7AD614" modified="2024-05-29" version="1">MFFGNAEDSNMLKLQKAEAKLIEHAKNFGDRDPSSFRITTQDTSIPSVVLPLKEKASKSLKQDLFMHSVRVTGTEPDPSKHDTPLVILHGYMNGALYFYRNLVGLSNHFDTVYSVDTLGCGLSSRGPSGLLSSLASKDDASSLEDTTEEFFVEALEAWRKANGISKMVLAGHSMGGYISVAYCEKYPKRVEQLILLSPAGVTKDDEEEIGDMFGQMSWTQRAAFSGVRYLYNSGVTPASFSRKLPTSKSRSMVASYVEKRLAVVKDPEEQQAVAEYLHLMAMIPGFGEDMLNRFLTSTANGVKPTVDRIPLLQVNKVSFLYGDRDWMDIQGGIDAYEQARRSSSSGPQILVYQLQEAGHLLMLDNWKGFHAGVVAMVSGRQAVSSSKYPMPELVRGGPRRRKNNNFAPRVGRKLQQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNB1</accession>
    <name>A0AAD2CNB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000757">
        <property type="protein sequence ID" value="CAJ1938727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="126" mass="14169" checksum="964B02AD45314168" modified="2024-05-29" version="1">MNVPMVSGATAYDCPQSGTMFILIFNEALYYGNRLDHSLINPNQVCKFRIPLWDNLFEERRDVGIETKPIFVALKTKGAKLLFDSRAPTDQELANCPHTDMTSKVKCLGIQVLSNLGKSQLFTKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQW9</accession>
    <name>A0AAD2CQW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQW9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="407" mass="46219" checksum="B64F180C8CADD8B8" modified="2024-05-29" version="1">MASTLISTTAPGKVFSSRSELAEHYKSDWHKYNLKRREAGLPLLAENDFVTRWEAALALKREKDAKAKRGKDHIKNPEKKNKQKSGENKISVNESIAASQENPEINPYQSIFDSKSFDSLEENVSYMNKNYGFFIPDSEHLTDLEGLLGYCHEKVKLGHYCLYCSRVFPTWQGCQNHMISTRHTKLRYEQGFWEELDPFYDFTRDNQNFMGDSNNDEKGEEVASNNIKNIAVTDDDDEDWEDVSETGDDDDDSAREFRGYEKEIARFGLDITPLGELVFPDGRIVGHRALHKYYKQNIRSTATNDAVVAAKTAAGERMYEGRVVNIKSPLPAETNGGSGKGILVPLKGGPEAFSALSLYRYTAAVRKQRVDDDKGRRLKYRTTQNMNRMDKKANRLMNGVSVAHAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU61</accession>
    <name>A0AAD2CU61_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="483" mass="54246" checksum="5B8B59BE14B0B0C3" modified="2024-05-29" version="1">MPTRTANHTVTTNPNGNEEGHVTLPLGFVSSPPVVVRRTNTSPAGLTLLSEISSITLPPSEEDEDDSNEICQRSNAPTDTLEELVDSDNDDALDRLEPDDNSMGGEEDFQVLTIEAESAIEDRMYQLCIAGKPEVDNPGNWNEYIYKSRQYKGHSLPSGAQPVPVLEGGKRTINGWEFHYGPWTPDDEGDDGPGSFRSGATTENMFPESRKGCLSVATLKLLGLTKSRMDGDDALFFYQLLYPICDPKRSGVAKDPREAYYFDVETFTRKYAASLEYGGSYGQTIKPVLAAELLKFHGIMVRDGVHGGSRGAVYRLWDPTCSCYDKDVVNALSLYRFRQIKRIIKLNDNAKSKPRGHELYDPAHKYDMAYRVVVANCNSLTLYAESDLCCDEMTWKFMGYGEGGVVRRIVGKSLVFKCQEVVLKSCDRACAMGLMDIPPRSQYLFQDSHETVLNKSLEDRQHWLRLVSRERAINRRSLARQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUA2</accession>
    <name>A0AAD2CUA2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyltransferase</fullName>
            <ecNumber evidence="14">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS8799</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="14"/>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUA2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1944261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="326" mass="36920" checksum="4ECD21C1CF71B407" modified="2024-05-29" version="1">MSFETSTAHQIWSYVVFNSLFAIIISFNLSLIAGLWYYPTQTLLGFIIPYYSYIKILAPAEFMATGMRWQSFSKDFAVLHTMRKHLTLRFAPPPKKLVQAEGKPDAQFLIATFPHGVASEYRVAMDGMMREVFPNVHDKVVVLTASVLFAIPLVRELALWTGCVDARKSVAEKAISMGRSILVLPGGEAEQIRTIYQKERVYLKRRKGFIKLALKHGIPVVPSYLFGVNDYYYTSSILFQPRLWLQKSMGICIPMAVGLYGSIFCPFAVPTTVVYGEPLSFTVKDKLSPTSEELDAAHDQFCKALKDLFDQHKKELGYGDRELEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUU9</accession>
    <name>A0AAD2CUU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35748">
        <property type="entry name" value="OS05G0358400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35748:SF1">
        <property type="entry name" value="OS05G0358400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042175046" description="Gamma-glutamylcyclotransferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31214" checksum="EF23DDF69C68B259" modified="2024-05-29" version="1">MLDILTALVISLVLYDPAARIPKVFAYSQITSTVRKGQQSEIQDKMDSKDDWITILGFGSLLSERSSRTTFPDLKNFRLGRVKNYRRVFGHPASIFFQRGIANLETKEMSSLSTEYLEGHPGFICSVFEVPNDDMMENGLPSPAFLEREEEFDIIEVPYEESDGKVVNKGILCAAGTDSIYLKRWGQKRFEANYKKYGVEKIWGWERDSGLRPCAVYLRHCYLASKSMGDTCLDSFLDETVLVDRKTTVREYLKENPQVLETEPPPSLVGRYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUY7</accession>
    <name>A0AAD2CUY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS8774</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1306"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1348"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1386"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1420"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1463"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1502"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="601"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1581"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1944210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2008" mass="221493" checksum="139D7C1FCC295D99" modified="2024-05-29" version="1">MIGSNSWRALMWRNAIYRRRNIIGTILELALPIGFIALLVLIKSSVEDTEGFAPQVIEAEFPDTNDATLMFSYGDYVTAMQAKRVCKIDFGGEYEISGMPGRGFNWQVPFVKCDRRMCTEDGQDASPFCQYLALGVAPSSASDSVGKERAEAFRNFVHNQFPVLSSANTTSLPFGFDFVQVFDSELDLENYVTARDYRLSTDEKPTLGLAVVWDGTDGGTDSYSYTIRLNGTNFPNPEDQTQPGTSTTPPTDKDFDHFAKNDESCPRLPGSPRVGAKAESCTRRYMINGVLPTQRLIHDFIFQDSNAKDAGYFVAEHGVRFAPFPSKEYVSEGFYAAIAAWVPLLVTLGILYPVASMTRYIVLEKQNRQKELMKMMGIQENDIGSSWYMSFLIFHIFTAVGCGAVTKLFYPKSSIDLLIIFWVLSFTSLISMCFFLASFFTQATRATLVGLMFTFGGYFITLFVDYQADPSSTLMAASLHPTAAFGFGLQEIGRLEDAGVGLIWNTVDVTDSPSGFTFNNTLSILLVDTILYAMLGWYTNRVIPGEFGRTLPFHFPFTKAYWLPGSVAPGTSTDAIPENSALHSEPVSKTLKDQAKEGKSIEIRNLRKHFGDKIAVDGLNLSMYRGQCTALLGHNGAGKTTTLNMLTGMMAATDGYAIVAGKDVRTQMAEIRQEIGICLQHDCIFDNLTVKEHIQFFAMVKGLYKKSTSKEAEEKIKSSIQDVALWDKRNTYSKNLSGGMKRKLSVAIAFCGDSKTVFLDEPTSGMDPFSRRFTWNVIRQYREGRCIILTTHFMDEADILGDRIAIMAEGQLRCVGSSLYLKKSYGVGYNLTIEMHNEGDNAADVESTVKEIVTSDVSGATILSNIGTEMNFQLPIGSSSGFVSMLTKLDDEIAKGDVANYGLGITTLEEVFLLVARGDSAEKTDMTMSERNLADDENLEDIRKIKLEEDLFGTHIGALFRKRAANFKRDKKAWMCSTILPSLFVLAGFLIVKYSSSVQEFEPIDLTLDTFNDQVSESPRNPITINSASIFQCQPGRCAYDSEFFEEETTNETYSYCGYHTNIGNNSTCSGGEPTDDIPNMLKDYGSEAVYASGESVLQSSRSIIDTAEMFAASQYGGIYFTSNDASTVQINQNSVAGSGPDLEALLAMFGGDLDALLSQFGGGNFTDRQDLLSQLGSFNQTVLEDLLSQFGGLDGLTNGGTSNGTDFGDLLSQNLTYGDLVEASCLRQQDDYRNPISCSLYRGLGYLIRYNFTAIHAAPIFQATADEAIIRHALNNSAFKINPSIFPLPLTQFERVTQQNDDAGVPWFLIVFGFPFITGSFATFVVAERESKSKHLQTVAGVKPMAYWLSTWLWDVANYLIPMTITIILLFAFETEAFTKTEHDVVYGVITLLVLFGPAAASFTYCTTFLFKSPSVCNLVVIISNFLVGYAGAVACFVLRLIGDNPFQRDEDLYKAAIITEWVLRFFPSFSLSKGLFYILFIDQFHQLKGEEFNVWHKDMILFEVIFLAWQSIGYLLLAVAIDSLSSNPRAVSIWRNIFCCRWMSSSYTAQSINGEIDEDDDVMAEQNRVLDGDTANAAIVLKELTKTFDNGLTAVNKLSFAIPPGQCFGLLGINGAGKTTTMSILTAEFPPSGGDAMLAGYSVLRQPEKTRRMVGYCPQFDAHFFNMTGREHLQLYASIKGVPSSKIPAVVASKLREVGLSDDDSNKLSSKYSGGMKRRLSLACATVGQPQLLFLDECSTGVDPVARREIWQMISNMVSNRNLAVEDRPSVILTTHSMEECEALCPRIGIMAAGRLKCLGSAQHLKSKFGQGYQVEMKIQNVDTRDEDFASNLASISTSVGADSPSPVVADADVDQEQAIADSAPLEEGAILKLDQVMVALQSLTGDDFLTSKLNANDPAGYTILKDASAEGVSLTSLAYFATAELRMKKLHSFVQEHYPQNVLRERQDTKSRYEVSSEGVKIANIFGDIEENKGELKVAEYSVSQTSLEQVFNMHAAEAASRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVD0</accession>
    <name>A0AAD2CVD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="270" mass="30250" checksum="EB866795EF8AC85B" modified="2024-05-29" version="1">MQRRRPKAKVAQNDVERSPVRDEEKIKRRKRRRSGNSLRLRAAVCLVTCLAFTLTAAAVKMTMFEHAKEAQNIPLISSAPEEETEATPKAPEDSKIVECEISTKNWNSDEAASGILRIAVHKNAPSSELFLYLVSEGYYDDNYIFRVIKGFHAQWGFHTPSDMKQWWSRIEEKRGDFDSENEKTDLKNVKGTVTMIRGGAPQVFLNLGSAPWLDEEGTLPLGVVDLDSLLLADKIYTGYTPGSGQIPAMSNGTIPELFPKMSKVEKCSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CW04</accession>
    <name>A0AAD2CW04_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS6202</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000742">
        <property type="protein sequence ID" value="CAJ1938612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CW04"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="61"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1938612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="187" mass="21137" checksum="FEDD3C70309FFDE9" modified="2024-05-29" version="1">MATIHERLGHLLYPRIRLLARAGLIPRELATIEPLKCPGCAYGKAHRKPVRHKGQRKHLQQATRPGEVVSMDQLESPTSGFVPTHRGIPTTKRYIGATIFVDHYSDFTYVHLMTQMNARTTVEAKNAFERIAKSHGVIVEHYHSDKNGLFDTKLFRSTVQDCNQTLSFCGPNAHHQNGKAEKNESRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXW8</accession>
    <name>A0AAD2CXW8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="58" mass="6216" checksum="EB07E8CAA4F1BB50" modified="2024-05-29" version="1" fragment="single">MSLSILQAGPAIMYGGLAFGLGFGSFVHQKEPSWKIPAMVCAGFWGFTAFTVDQEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZ13</accession>
    <name>A0AAD2CZ13_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001613">
        <property type="protein sequence ID" value="CAJ1946148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZ13"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="404" mass="45384" checksum="EB6B255C1FD0C658" modified="2024-05-29" version="1">MTTDGQLPLSVNTLIPNEDDEAKVNIVTPPNQGALETRLDESGFVSDDHELESVEEALEARQQSLAILKDIPMQFYSVVPWELVATIWSRNVSSDQMAAACQSAVPEFFDKYSKKTLDERSKELFLKHCNSCLAWPQLDNARPNDVFCEFLKTTFVAQPLFSSVFASHKPPETTNWGIETELFLPALISHGTRNRSGAVVVGNHIAGCSRKPLEGPRLSAVCLIEKTIKEGKCNPRAIIEEDEPTLVFDSQLQMEAALQQSCQRRKIMLKEMREQVALDREDRDPEFRRISQMLIIRVLTEEVNETGVSTICVGEGKGQHKVDYVRLPRRRKAFSELTPKRKRQIARLLKAIVIQLVGSAIEEQEELLLIFIRGCFATLVLLCGVASLYSIEESQHCEIGSNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC55</accession>
    <name>A0AAD2FC55_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1903990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC55"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1903990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="326" mass="35609" checksum="DFA4A8D313CDAC37" modified="2024-05-29" version="1">MVKLFDLDAEIGITLLVVTSSPGGSYSNWWCSMFNADLALSVTMTAISTLLSVAALPANLLLYAKMAYSADITEQLDWRSLFTSLAVVIYAILFGLFCSWKIHSYKFNIVCNKVGNVAGLLLVIFSATVANTGGGNVAEGEHVDRIWSRGFQFYAACSLPCILGMLIAAGLATVVDLKKPERITVAVECCYQNVGIATSVALSMFKGAEVTKAMGVPLFYGIVEAVFVGIFCIVGWKAGWTKAPIDVSFWRMITTTYEVLEAERIGQSEEIEVAFTDDDASAETQEGHIFTTFFSLENLDKKPNSRKEPSGELETVYPELRDQNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCV1</accession>
    <name>A0AAD2FCV1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS2679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000202">
        <property type="protein sequence ID" value="CAJ1932077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCV1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1932077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22474" checksum="3E7CB09B94A8CE54" modified="2024-05-29" version="1">MSILEYNGAAIIAMAGDGCVGIAADRRLGAQLHTIATDFTKCFRMAPKLYVGLGGLATDVQTLHQLLEFRMNLYTLKEEREMTPQVFSHLLSHLLYEKRFGPYFVEPVVCGLDEKGEPFLSGMDLIGAPVTAKDFVVTGTCTGNLFGMCESLYKPKMNPDELFECLAQSLLSSVDRDSVSGWGGIVHIITKDNVITRELKGRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDA4</accession>
    <name>A0AAD2FDA4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000080">
        <property type="protein sequence ID" value="CAJ1929396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDA4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1929396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="342" mass="37120" checksum="D4EB711D3609DF7A" modified="2024-05-29" version="1">MIVDQLLEEISKSDDTKENELNAKNSQSQIVKLVDDLVEWKPPESSDSSPSAASSSTEPKNNESEDQEENFDELIGYYNVSYTLTSKPKENPVGGKWTRSQRLLKIQRTMQHVLPLSSSSSTSSSAKGAAVAQVINAIFLECFWGLLPIWIVLRGDAVPLNKIPKEEPSTKATTNKGKKKKSPPSLLPGLSPRTVRAYFDSPRFAIGKFVFSFGPTSSVVLDTPYIDDRIRLGVGGTSGTKFVFSRIKDEQDNEAVDGWKWVLEKESTITKTKASYGLLWTSLLSGFAYKSLRFGMGKIVASTVFLASLVSLGLVMASTGGIETNSDNYTPGVAEAGGGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDW2</accession>
    <name>A0AAD2FDW2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000153">
        <property type="protein sequence ID" value="CAJ1931487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="495" mass="54235" checksum="D135097BC231B482" modified="2024-05-29" version="1">MWHVYVRARHAKRVDRALRLWLHPSTPKKDFPWCAVTHYISDWKAAQNGIISVKAVGPVKDENLTMISKHNNFVELTQAKYCPVEIPGMLKQATTKDFGPRTCLSMFLSVKARSLHADKVAAADVDTDSDSDDSLLDDISHKFTKVSTKGKTKIKKKVPKTSKHLSLENEGPVLTPAQQRRARESERKRKMDLENNVPSPLFIMVLPGEMEGTYLFISRLKVLGKWFPKSLIHTTRRKELVWCLETLRARPADQTQQGVDEAIDFLDGFGSDPLDVGEAKLEFDMDMADAKDIDDGATVAGAMDELLEKDSQLEAAITEIEFKDNLLSEQNSALEAERLRSEHGPSNKSPTEEDVPPPEKPHSPSTPARSNKLGPLTSPLPGSPSPAPGPKTMLPPQSAATRPKSFVESVTPDQAPRTAPTAHPPKRDGGPNAESITPSLTDTQGSGSQSDASTPSVFPIFRHPHQSPPSVPVKGKKGKKTPLANRGASRSTAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE88</accession>
    <name>A0AAD2FE88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000202">
        <property type="protein sequence ID" value="CAJ1932041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="95890" checksum="236D829699BE97EE" modified="2024-05-29" version="1">MKSVSAHSASQSRIRAVTPRTSRGTTISAEEEPMNAWNWAQQIESLLDSNYSEGEVSTSREVQMPGLHPKIIVKGMPEGDSRLSFPLSKSQALALKKSTATKREYFGKKIRNAWPVDANRVQFLDSNREWTTKLKQITMKCVDDLGLQEDQKCDVKANLHKMLLYEAGGGYFYSKHNRGTETEAGTFATMVIQLPSKYTGGCLQICLNGGELKYDRSGAKSDDGFFVTAFFSDCEYELSPVTSGYRLCLVYNLILQDTSWSSDLPFPSAQTVGSTSQALQRLVQRMPTKDSWDPVQGYSLKGKYTKTNLHFYNLKGRDLDTVSLLRDAVDENGNKLFVAYLMLLEKSVDGQRYSSYDNTNWDDESDGEEFRTHISAVHWIGPNDTMLDHFNLPFNINKHLVVDYPDDVFDETPDNKNYENCDGNADPTLEYWKGVVVFWPLAKNPEVMKQAGRSFLESSLEAATIQSDIQAYAKQLVSLFEETRYESPTGKAIRAIARSKDDSLIIRVLDCIKRRIPINDDAVGIIEVLKASSSETLKQSFFTMLRRVSKFEPPPKQPSKQSSKKSSKEPSKHSLKRKRLNMLLKLQHPNVVAELKHLSAVLRLLESSGLNDFVVPAKEAIFASFIEHLDSIVRASSRKYIGQLTEPFIDEPAIFKRIVNIVVTIPTFVGPTLKHVMTLVPDASANKYVVQLAKVRAQELLSETRDGAPIFTWCQPQSPRWTMSQSQAVDTFLQGPNEIQSFTGFSDIGSARNWAADFSRLSGFDARKLGLPHFHVSATASGSGSDSQVVVTKTKGYWDGVKKAYDEKVAELKKLQSVFGTSFAPKRRAATTQGGTKKQKSSRRGRRGSESASRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFX0</accession>
    <name>A0AAD2FFX0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000453">
        <property type="protein sequence ID" value="CAJ1935343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFX0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="101" mass="11138" checksum="604343F2410F6A6B" modified="2024-05-29" version="1">MSSPLQIYFSNLKQQHRLDDIVVVEDRSPSSLPRRKVVMSNMVGMRSEESSSSSSLCEIITQPLIATEDATMKTHDSNKSNNNTAKPMPSPIRMKIAASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHK8</accession>
    <name>A0AAD2FHK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="261" mass="30696" checksum="037B7EFFBE77A93D" modified="2024-05-29" version="1">MARSEEALKRRAEKRERSVQEQKQAEFEEMKKKQRLLEQEKVMFTIKHQRPFAPRSYDRDARPPPKKQRHDPETSKALVWAEQAKEDKLVQNQALRKKYQETGGEGMDPEELERAKLLIARDERKKQKKAMKKERKSLEMQVEERESKEEEGDETKEEGKDQETSSSEDGKKSSQDESSTKEKKGSIDNDVKEKKVPCKEDHDAKSKQNAKSKRDRNKALRARFQETAGKGMSKEDIRRAKQLLERDERKKQKRASALEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIF9</accession>
    <name>A0AAD2FIF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein ENHANCED DISEASE RESISTANCE 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045096">
        <property type="entry name" value="EDR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136">
        <property type="entry name" value="ENHANCED DISEASE RESISTANCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136:SF41">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY (PH) AND LIPID-BINDING START DOMAINS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein ENHANCED DISEASE RESISTANCE 2 C-terminal" evidence="1">
        <location>
            <begin position="142"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="380" mass="42892" checksum="A1432BC85514F337" modified="2024-05-29" version="1">MDSCFCNTGDLLMGSPFEPYEETAMMEEKHASSFRKPKSQDSVTYVNSSSSSLSTLDQDAITITNSASDASMPKAGRASPKIICQPRKHSTAIAKSVDSKHPFLMGRTAMVLNSEPSKLTVPREWSCTQFRNEPSPLRKDAWSEPKASNFQVRGKNYILDGKKFPSKEAAFQLLAVDMVHSEGTIREGLCGHPNERVQRAIRREKETGVSQLPPFIFAVNLSIPGTQTYHLVSYYAVENMEEIEHQKTPFGRIMNKFIFGDSDEFRNETFKLIPRIIEGNYIVRSAVGSKPSIIGKKIKQYYILGERYMEVVVDISSDSIAQRIVRLALGYSSKLVTDIMYVLEGKDEEELPERIFGGLQLRKIDLGNRDGQRKVQRWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIW6</accession>
    <name>A0AAD2FIW6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001147">
        <property type="protein sequence ID" value="CAJ1943859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIW6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="519" mass="59265" checksum="E8D895D0BF5CA997" modified="2024-05-29" version="1">MKAIPEEEKSNSTMETVATSIGNSPNPMSKPVTSRSSSTKSVRVSSSSARSGSTSSRTSSTSGANAALVSRNGLDPAVVQKSLQSELQQWKDMYHKQQREMQHRIDTLEQENTDLKQEQDILNDRHQSHTEELRYMQNEFLCIKGHLNKLRNDMESLDGLLIDQQLQQRQQKRSREEHQMAEKVEEAIFKVKERQEFTCVFMDNTISSIDEILNEYIPDKVQYADVEDHKTTEEVIQEAKLREMREEEELRQRRELEKQLMEQLKQEADDAQLVEDDGDAQDSNFTSSSSQLGNSVSSTLALQFPDEHLSELGIETPAVKEAKLSQEAQHLFKEQHKMFAKYIAESRSDVAETEPAAIRFKGWFEEKREKWREEENMKELRQKKSQSQAVMMHKVKQMHSETFHKVTEIKLHHHEQAEEEKERRSTLLKIDGEDKNGMDGPGAVPEPAEDQVSDLPEEEALRFSMNKGNLNDYFKQYKDHSQSVGGGLGPQSLEPKPAAGGGFLSMVFGVGKSENELSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJF0</accession>
    <name>A0AAD2FJF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS9230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJF0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1945086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="293" mass="31825" checksum="577463EC6CD8C19C" modified="2024-05-29" version="1">MRSILGDADIVRSLVMLLSLRQHLLNGGKSYGPVCMSNSPIVMEILANSGYNHMIIDHEHAPTDIASGQTLLQAIDVVRSTTSNSIFPIVRVPDHSLSYLKKVLDSMRLPGGVLVPMIEDKETAEVVAAATKYPRQVNSDSSVDGIRGCAIPFVRASGYGTNPNYMKESDRDLLVMVQVETSKGVEAIPEISSVPGIDGIFIGPFDLSCSIGKTGQFDDPEVKDLIHRAERMVVESDCFLAGFRSGGRDLREMYEKDGYSLVCGSIDLGLLKTAALEDARVANDILHGDKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJM8</accession>
    <name>A0AAD2FJM8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000524">
        <property type="protein sequence ID" value="CAJ1935915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJM8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="983" mass="112829" checksum="B4825EFD99A2B2C7" modified="2024-05-29" version="1">MKTRLEIEDRISSPYANPESYLLKRRSANRAKRRREILDFVDAALYPEQASRKSSLLNDWIDDTDTEEIIQTSQGSIFFSNSAEKQEQTHLVYPVSDNDHEEPDEKLPDEHDTNYVYEEEGEEDDDDGAWMSSRYVMPKSHRAKSAEKQEQTHVVDSVSDNDHEEPDEKLPDEHDKNYVYEEEGEEDDDDGTWMLSRYVMPKSHRAKRRREILYHVDAALHPEKASREALLLNHRRDEMDIRRSSQVSSINMAGIICDNYAAKEEDIFASISDDNHEPGEKSPEDEHDTNFDCEGDDDEESILYEESEPSMYDENIVFEQEQDVSSSSFLDDDADDFLYIISGSCEEEELFFRVEEDIIYESEDDLEEIILAQDPLETIVETGEEESDQESTGFDEAVDDVETSDLLVTIVEEDIERDDDFFQERILYESDLQSILKPETKDEPGGTERISFVTACETLEADEISVEYSIEEIILFDDEDPSYSAARTFIHETIEYEASESSIDEFWQEPEQPESPQDCSNSSFWLSANGTFGHGISELSIDVNGEEILCQPDVSKIGDKAIEHRPSEASFEETNPVYDSGNGAKEPLTGSDDGNITDKTDDDIMWSDSESCGWDTYSQADLLAEYEEDARFQFPVPQIPVLKLWQHNHRNTQIQTVNQEVEENGYCKSIDALEAATRTPRNILIAILAQGDLQFKLRKVPVEHKNEYKPIAQSASSIGRLTRLQEQVIESISLDDNSSSQEAEQFVPRKSPLANTRSSGQRLSIEAAALGKIVRRQEEYFTNWDEEEEGNESLTNETVFSKNTDVFERRISIDDARDDRGMLVQRTSLLIHHHVRDSRIANMEKDWAMEEFLEDEEKYSNNNHELDLPKMSLPKFQLPKSERRLSREEMIESLAKGVAEKSWERKYRLERPGAQLRMHTGCTCVYCCKNKPSQSQTHQHCYNVVTSCTGNGMEEERTPPSPLEQDSKPKVALDWSCAFNGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKE4</accession>
    <name>A0AAD2FKE4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Replication termination factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKE4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="31720" checksum="ACA379149327C736" modified="2024-05-29" version="1">MGGDGGVVAVNRRYMRGAGSADHTGDYAKEGGHHEHNGLEAMTTCHLTKLPLFSNGSNGSSGSIGSTSSGPIVACVFGRLYQKEAAVEALLTRASSNGGGASLTSTTSVLGDHVRKMSDLHEVRFHQDTAATSSNTKKKGIVNLTCPITGKALLGIIPAILLVPGKAGTPNVLSESAFDHLPKEELELEYGPIKQKIRLAPPPELLKQLQEEELENRLQKKSKQQQKKNKKKRKQDGEGGGEQKSKPKKQAKANIGTAAKSRVDSAIESNQVLSSLFTTTNPSKKTDKERKDGLFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKP9</accession>
    <name>A0AAD2FKP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS10082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1945940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1221" mass="135080" checksum="B67B0EC9FF698468" modified="2024-05-29" version="1">MTTTTTQDEKEGRTPIETAEELKEILAKLELEYEKIKERVGKNAANVRELQHKLPKEEKEEVASDEGESWRVIGSGEFTDEPKTEENIFELPKDVYSFMATYSWKSNPFWLALIVVFGLQFVLLFLLLANQTDFQSDNPLQLPENVEISVRVSQVLLMVIAMFQQDDLLVGIETLVEGPPLVFLGKEKFKHLSRIQWNISCLIRMATGILGLLAAFILSIQSSTVFDVVLNVLGVEFVSNLDNVAFDLACKGYFGRYAKIATQDVSEATFHREKHQAWIKRVLHIIIALSVLSLILAGLVFIFYRQDSNFLSIREIQVQFDDDIVPFLGLFSGCYTAVENSRLRYFGDRRLFYVQDGFPQGGKFGFCSSFDNGESGWTFFVGDFRNPCGSYLMRSEDTQTFSILEAAETLEWFTAGEEEEPVGHIEISEMTNRADDCGHTYFEASFEACPVIQALGSISLHKLIGTNVSDNDSVTQIEEIRERGVLDPAVAHAIYYGESDSAPVGVYDLIFFAGRRWIWTTTDNIPGLQNATSPSKITDYFYSPTEGSSSLGLFRLVESLLATGGNQWVRFMSEPVDADTESPLGLEWFYPLYNDETLGANANDDSAYSSIIPKMAFPPPDTSRLLDSESSPSCQFCDLLKNPCFFDGECNEQTGVCNCRHGATGALCRDRPLANGICNLFFNSAEHDYDGGDCCASTCTGAFCGQDDVLDPYVRGVPSFNWLDASDSGDMFEITSKDDEWIEQVEGTTIAFGVNVTANLTYQFPPLRYEHCIDPDLAVIRIEVLPSPLLEESNNDLVFDGITLQCEDTTYLKTPIFRVSNYNVTMFSEVVRIPYGSHCAFGFQGPGYFRGVSLLAEGNAKPFINLQQSCSVDVYIPQSKCVWETFAEDSISVSSVGDPNCESSTNEVNEIRQISEVELDALGSDPILDGFCQQDPFQLLERFHVWDILSRGSGELVRASVGHVCDGGWNTGVFSVSCNRDRRISGLALKAGANASFVDSMTLNVKHFANLKRVEVQSGTGPVDRLLEEMATLNLTSITLGSDVLPSQIGLLQSLKDLRLTSGMLTSLPTEIGVLSNLEVLESHETSLRSLPSEIGSLTSLLTLDIGGNELISVATEIGLLERLEMLSLERNALSSLPSQIGLLSGLQQLLIQSNRISTLPSEIGMMTSLRSMDLANNTLVSLPSEIGRLSMLTSLDVTNNKNLSQIPAEVLAMTSLEVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL01</accession>
    <name>A0AAD2FL01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL01"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="807" mass="87320" checksum="F87FDA83B597BFF5" modified="2024-05-29" version="1">MKQSSRIPTFPSLMFAHPNRATAATATASPASSSFSLFRQGGSAEQKQGHFQGPSPPNTSNASLGGLSSMFCPTTFAPAAAVAGRSATSTTRTMATSATSPTTTIAKILQSLRSVVLSPGGIATSVVGLISLIIYLKYQGAIRRRLKQVKEESWLFGAGVTMVRGEPNQDTNVFPNLKLLQVNPSFQKAHPEWKFVGLGDYLSTLRPKQLPKGFNSKDLPKLVQRELEAGLASGLLKALGPNLGRALLPAVGVGPIEGQAQKFGSKLATRWILSQQAASNTLGEDDDRAGLPISILSVLALSENNAKLNSGEKSSKAEDVSDADDKLPGSNLSAIQKMKNGENVHGPAIDTGILPNSGFVLDRDFHKTIRKLENTMVDQGHCADHAPIELQTAQAEIKEDSEYEDVNTAKDSDIDTKASQQYDPNDRCMGEPVPINPRLFPDLHLGHGGALSTHTKRQVLQMRLVAVLLNRLGANYHRLANPDDKDPLFTIRLTEDGPAISKPAEFIQGLINMGHDITVVPTSRITSFGIGMCIKESDGSWSNIPIGVFLESGYEDKDGNMAPAMMPHSGLRLTIGDGPLTSKQDQEYDDFNASAISNPLIIQHFIGIEGFCGWKPDADPEVPFNKNVESGRALKEASEVGRAVRLSALYANVLNGLATEMELPFGGYGVTAVCNDSAAIIQQCLYGKSYIFPLTSIGRYMQRTLRYTQSMESKLQSVTELEDELDDLYALQEGMLELPSDVNSTPANARDAARRVLKTLQPDLPLVLMKDSKTIMKNILHEHEEHKKQTSETSLSKMAETLGVSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLE7</accession>
    <name>A0AAD2FLE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000894">
        <property type="protein sequence ID" value="CAJ1940496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="170" mass="19069" checksum="FEE883B515AA895B" modified="2024-05-29" version="1">MSTPVLHIRIQEKLGTPKCKTIRALLDSGTSSTILDLRHAKKLRVKRASTTSWATAAGTFETSQRAKVCMQLPQLSESLTIDTDVHLAKSISPRYDMIIGRDLMRELGIKMDFEYDMIEYQNLSIPMTDINELDALNDLQFITGIKEPKSTAEAVERVSKILDAKYAPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLU1</accession>
    <name>A0AAD2FLU1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLU1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008716">
        <property type="entry name" value="NodZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05830">
        <property type="entry name" value="NodZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1942912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="384" mass="43636" checksum="76B19DA8068ED184" modified="2024-05-29" version="1">MSLAAYVAKQKRFELRAFWGWCGEKAPIEVFSYLFRPYREEELSHIESRGLLLPFYNEISGFLAISRQPVTDQSECACPRDKITSDLELYTSLRDRFRGKPVVDAFVRENFSKATVVGIHIRAGNGEGGDFDRKGRSINNLQVWVGDVVKLVLQEGFRKAGSNELVVYIATDTPSTIDMFRNQLSPHQIKVLDLPQTRMEEGTGVMFGEAAKVHNMGDETDDYSSCLKGWTDTLSDMFLLSHADVVIAATPSSFSQTAPMSLAFGKESQGVETPYCEVIPKFEPHKKKETTEWKEVAPTMQCYKSYVDWCCNYSTWIKFKKQGRQNRTKIVSKEFLRFPLPSNEGTVKDYRGLRNRTFDCRRPGRGRAAGGLKDKCLPHAWVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM49</accession>
    <name>A0AAD2FM49_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM49"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004684">
        <property type="entry name" value="PRK06027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036480">
        <property type="entry name" value="FormyFH4_hydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1944551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="287" mass="32783" checksum="D81EDC743479217A" modified="2024-05-29" version="1">MALSSRGRLGTLRVFGPDSDGIVAACSNLMGKYGCNIVKSETWSDQKENMFFNRLVFTHDQPDKVACQQDLTEICKDFQLENRLNWRDRKKKVGIMVSKYDHCLWELLLRHSANELPEMDIELVISNHPDLQSVAETFQVPYHVIPVTPETKAEEEAKQLELLKNVDVVVLARYMQVLSGDFLRQFPENIINIHHSFLPAFMGGRPYHAAHDRGVKLVGATAHYATEDLDEGPIISQDVISVTHRDGVKDLMRKGRILERNVLLKALEAHLEDRVIVHKNRCIVFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMG2</accession>
    <name>A0AAD2FMG2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMG2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184:SF11">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184">
        <property type="entry name" value="SI:CH211-189E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="872"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1137" mass="128333" checksum="700EB11A1CF009DB" modified="2024-05-29" version="1">MRGLRASAPAFVPQIDPESYWSKNGDSKNTDSSKRTNHLKQKLDDNSRARRQTGRGRGTRKGKDTKIAVQNEDESRGSLSIESNQKGGNRRKRRNKRNRLGQKRKSTREQSSLHHRSYPDIPANPLQSENVFPSLGNAVHESKTSSVWKLTSSNHLIFQPFDEAPNNTENNVDEFERLGLQRLSSSQMNESISTSNETKRNPMHSQFSEPMLATDLEESTVNEGEENLEANQLPSEKQKWNMNRLRDRWWRALAMQRLHRKLMDELKQQFADQCRETEDDCETSDSDSGCYLEPVELSSMNQPKSREPSVPSTIVNEINKQDLGGSFSSPTEAVLNAIRMNDETVLHAILHQSKPSDHSADEMDNRFRSIAQEALFACLEQDKPHLLRTILRYTSTSSYTRLMKKHEATESQVSHLMIASELGHSQCIAVLLSEEERHKCSLPSRDMDGNNVFHYCCRGRGDEASLRTLLKELSNGTKWKQQVLSKLLLLRNKEGKTSLHVACEKGREDFVSTFLSLCTNSLLSKMLSITDVYDQTPLLAAVASNSTDVVTCLIMWRGNNNRNLWKKASQIPCGNTQPSSRLVENRQESGSPPCALLWAAKTGVINMIHVLLQFSSVSGSDYRVTEALAAVIQSKASDEDKSESARILILAGGNAFAGSIQMPSDSASSTTPIGVASSYGSARILQTLVQVGREELKAKQELRRRDPKLQQQPESFFRGIETAENSQMKSALTNALIESLFYGWQYQETNLSVQHLSSAVALYKLGAQLGYSDVERLWKSMQCKSIQLDARSTDVNMSRCFATSYLHHNLEMNSKPTKVSDIDRSMLSGHSMLLSGFEWLIDQLGRFGCNCAWMARRSNVDIKTENNWHGDDKVFLVIRGGEKFLVHASIVSLKSEKLASAIRFASMNDDPDDTERIPEVFVDIDGRMLRYMLQHIYHGSVFAGWPSNEDEIFRDLLDLMVVAEEALCPSLLQECEMRLLSSNPTRCFCWSCSKAVRSSLLNYWQAAECMYLTEGFGLLVTGSRALDVLAITEFVSGFELEYSIRIAPIPYPNTRYIPASEAWGKFDETWKTARAIRLLKDQATMIILLRFRTVIESVSFQESVQYNADPTSSLNLLSHQRLLLQTCLEELPQSFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMM3</accession>
    <name>A0AAD2FMM3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001602">
        <property type="protein sequence ID" value="CAJ1946121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="113" mass="12602" checksum="81A501A3034503CE" modified="2024-05-29" version="1">MAAVIQFCLDSVDSFANRTTSQVRKDIKSMRRAPDPNNANATIGVTVCEEMTIHRISKYGKLLILVQRTHTPALGTISFLLVNSMMKIRISWKGTPTHFLHILQSSTIAMVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNC4</accession>
    <name>A0AAD2FNC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="841"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="909"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1947105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1112" mass="120135" checksum="C4798137BA068299" modified="2024-05-29" version="1">MMSTDMDMSHRSSGGVQEGVFSPPLTRRSSHDTPPQPPSRTRYYDMSPQVPRRSAVANNNDSLSSSRRSPNGSSRSPRRGPGSRRSNYRRSGSSKRSDQDESLENSNHSTASSNRRQRSRSSSRHRRSRSGGRRSRSGGRRSSNSLTSPRRMRRSESQNQPGAYKYYDDIDDHAEAVKAKQSSRRSSSTGRRSPRRSELSSSSRRSPPSDPDSRQTSFSRRSPQPEEPKIYDDAFGDCPKTTAKKKEIPITPTSVLTETSNQEDMSDDEEIVLPGAYASNLEGDDLRLSRLHGRSKARRSRNHMRVSMGGLDPPLMDSNSSSAGSSSMTSAERSALEARKDSRRSSMMRAASERNRSSRRLLVRQHSASPSVSANSNIAIATAIRPAVSESESEEDIGEEIVNDEYFDHDYDNDDLEMSHQTTSMFSSSQKASVASQSHRTDLCESPDASESTATGSISEDVVTEIVKPNKFRRNNKRNKKEQSQRKMIQRRQRRERNYCLVAVFLLIVGGGTIYLLLRPDKTDDSSSSDIASNSNLDNNQNPTSHPSAAPSAAVETLPPTESYLYHPPSPQDCIAMKNDEMIIGQGNMTNRNFNLHFDVVLDAAKAVEIDSVLKELLEAIESYFVPSLAGCDDIMSSTKDNDGNRRRLALLRYVVANADVDGEVSVDESCTTTPEQPCFRVVVNLKVYLKGNVRIAQLLNLIVGVVELDGFKGVSLGNARKLEKKVDAAPVLAERWNLSDVFKGVVLARIESANAASSAPSMVPSISPSTSAPSSSPSASPSAQPSSSDAPFVVKDTTTSSPVVPNVASQGPTAGISIPPTSTDAPVPSAAPTRTSSVAPTIQTTTQTPTREPTETPSEVPTSKPSTMGSALPSRSPTASPTDKPSVAPSPVPSGSQSEPPTAIPTMSPSAEPSWSPSSAPTLGVSDNPTPAPVPESSGGGLPGGGGLSSPTEPPAEIITVEFDDLPTTDSGECLGGSPTAISGTYENIRWNNFGVMDATCFGCYGPSCPNAVKFAVTSPTVRKASFESPTERTFDLFSMWVYNPVFPFTLTGYAGDRTTQIHFASYPYVGTGWHQLDLSAFKNVAVFVIENTGPTSVFDIAFDAIQIRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP94</accession>
    <name>A0AAD2FP94_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001744">
        <property type="protein sequence ID" value="CAJ1948173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="363" mass="41568" checksum="1EA876C0168417BC" modified="2024-05-29" version="1">METRAIGIRLHYSSPTSKDAHRMRPLVKIQGHTKQVEEYGRSPHRQPNHCSGMEIQRRRSTALAQTAPTAHCERRPDTTRTELAQLCDTARATWIIGRSLDTIADSFELLGGTMVLTASTSEEEYWQLQHDIPSIETFAKRLVNNTAQPPVECLIVTNMEKYTSTTSEALRTIIRKAMTRGKTQCILMWTGTPPDVIIDEWEQYIKRETRDRTDLQIATHTARGSTAQADIDTKHTIILTAGRRVIEAWSRSLVKEDPYAQPGTIKKRYGRTKQKLHRIFQRGKARTKQSPHGRLTRTHTRTQDLRYHQNLPQLPHNTHDLSARHDSNRNQQRRGNITGPNDQTLGSPQPVWFHKRGQQTTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQM0</accession>
    <name>A0AAD2FQM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="168" mass="18428" checksum="7F6A6AD61D793CBD" modified="2024-05-29" version="1">MQSSKAGQDESSAAAASNDENIQVRSLTAAETDIEKCYAMRNQVFIQEQNVPIEIEMDSYDETALHILATYQGQPCGAARLVVSEDTKTGKIGRVCVLNSHRRKGIGRKIMEHSIQELRRILGTGNKAQLGAQTHALKFYESMGFGLVPGEEYMAAGGVPHRDMELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS44</accession>
    <name>A0AAD2FS44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS12966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS44"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47162:SF10">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN-CONTAINING PROTEIN 9 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47162">
        <property type="entry name" value="OS02G0192300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1951222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="518" mass="58292" checksum="0C8D7E1219107864" modified="2024-05-29" version="1">MDEGDSAMDSSLELNNGDGSRSSSPVAPNGSKRSQSPVSAITVESSTKATPYSSIKPFSMFDTSSIVKKRKRRLQMAQEECGEELEFPLHVCGLPIPEEVHGVCAKCKSDRDSDTILLCDGEGCDKEYHMACCTPPLDKVPTGEFYCFDCSVKGSTTELEEYLEEHDSQKLQLDDPSSFMETLLKEDVWNELNPKHAVEETEITEVPRSELDWTHQEDPQSLIGKSIRLYCPKGNHYHNGRIVDVRSNHANDTDCLVRFHAGSDGRKTALTTWVSLEEHCVAICTDIVWARFGDRIWRKARLWSRTSRELVPVMNDLIRLGGALRPVQSEPSRRPLKATKPDWGLLETMIGKAIFEYLELRKATNVKLPGNAKTPTGREAEIMHGLVEMELNEQERVKRWRNLPLKNPMHPKAITCQDEYGLGTLDYEVPRPMLIHPPQLIPQGLDRLYMVERIARLYQCKPSKDMATSLDCLLEDRPALSIQEITAMHRDRLCGDSKSEGAKTAAKTENPIEPNGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSJ8</accession>
    <name>A0AAD2FSJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31154">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31154:SF4">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42336" checksum="952D00048E17ED6C" modified="2024-05-29" version="1">MVRTTWGGVIRFLPAMMVLPVWLTIALREKVLLDSFRSYYPLSVAMIFGSMIAGSTPLGGGVVAFPISVLVIGFSPSQGRDFSLMIQSIGMTSASFLIVMNKPTLLVKYGELLAKTVLFNLVGLIAGMFWTISPFAVMCLYTTAVAAFALILAYVETCLHHNISGMPPKEQLTRTSFDMSVDDDRGDMEIQTKDTLVEEKSNHSNLSICCDTTGMVLLGILGGLISSQIGTGADITWFAYGSLVYNYRMGCIDRMNGNELTASSIIVMTTTSIFGSILRATSTGSDAPTIEVYQALISCACIVVLGAPLGSLFLSAEYERRLKGLFYILSFVQLATFGIIKIRDNVLAWIIVSGVLGWILVVIAIADWFIFQTESGLRRLVAASHNRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUA8</accession>
    <name>A0AAD2FUA8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042193852" description="Carbohydrate sulfotransferase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38089" checksum="7E8479B82F5CD6AE" modified="2024-05-29" version="1">MKGSLVRLIFLLSTGGAIWQITQQFRVQLHQGATAESIQSNHRENRRNDPPLPLLNDGKADEKVKRPALYGVPYSNELEEHGLLLSMRQQERFFARKNSLERDHGSSPLMFSTATWKYWNRWHALILNDRFAFRHIFKTGGTSLEKQTGSKHVQRKAIGNRRMIATVRDPLEHFLSGWQECGERFPEYMEWNYQSTGKGTNDEKSYSRRIQQWLDRTKTMAFRTAPCLGKCACAMHSFPQASFLITKKGTVDPKVDLVGDLRELPGLLEIVGFQYNESLGTGRNASATEFKTTYFPRKPHLIVNDTMKAICEFVALDYYLFDFALPIACRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUC3</accession>
    <name>A0AAD2FUC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 184C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS14268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="121"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1953665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="75589" checksum="A8AE1DB52FBA3E4E" modified="2024-05-29" version="1">MPGYYDHSVDQDDDEDGRYPLFRSDSDNSSKKATKNAGNMSNGNRILVIISLVLIVLLSIYFQMNQGKLTDQLSQDEQMINSMQTTISKQEKVIARFNSSVTNTDVIHRLGLLEETLATSSKALQDQLDSTVQEMNEKLKNTMMKLEETVDKAEQDITDSVQQVKEDYEEFQRKTNDQFSMENSFMIWQLAGTFTLLSCLISMWHMSAHLRELNQPIIQRKILAILWMCPIYAITSWFSLVFPDTEGYLAIVKDSYEAYIIYQFLSFCISVIGKGDHESVVDLLARRADHLPPPVSIRSFCACCCGAQKFENDHAKARAVLLQCQLFAIQFVFWRPVTTIATVMLKKYDYYGPWGAENASDWRAPQFYIFLIQNLSIFTAFTGLLKFYHLVDEDLAWCRPFAKFLCIKGVVFMTFWQGLAISVLGETMNETGGDPEQWATKSQNFLICLEMLIFSLAHYYCFPVDEWKEGYKVNFQKLHLGDSIALGDFFSDLKLVMTKSGSKKSKKGKRLSLQDTVEEGNEEIVDVSTEGYDSDDQADDASISTTATAEPEVKEAKRRLSHFLNGVTDADAETETDNNDDSTNDNPSASPGIMGRFSSGFNGFGSSSSSPDETPRKQNTTPKNNRGEPSETTSLLSKSPLKPSIFTTVASFAQSSETSADGEKSADGSVMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUG2</accession>
    <name>A0AAD2FUG2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001826">
        <property type="protein sequence ID" value="CAJ1953519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUG2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="207" mass="23465" checksum="D14A2D47CC59A109" modified="2024-05-29" version="1">MSERLYTMFTGPNADNNQQLLLEGKLPIPGGLAYPTQAFLRHCRLHDSYRPRPFPLTVEEHVDFWSCTPENKGSEPHGLHNCHFKAGALLELLASCDTAFRDLPLCSGHVPELWKNLMKFAIEKKPCDFRPQGMRTFQLFNSEAQANYKKAGRAAMKNAEEDDIIPKGQCGSRNWCVDVARVSNIMRNAFQVIARRIIANTATQWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUG3</accession>
    <name>A0AAD2FUG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier family 66 member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS13590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUG3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1952512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="257" mass="28169" checksum="A6F46A4EEB717B20" modified="2024-05-29" version="1">MVKNLASIPLVLPFAKWVWEAADNPEEVSPDICLSEVPFLSPGCFSALLAKALGVAIILGSCVNKVPLIMNMQKSKSADGISRNSLYGEALVYAACVFYGLLHEYPFSSYGENASLLIQNFVLIAMAWNLSATPVLTQEKVISSGGFVAFSIAVMYLLPEDLRYLLMSGTWPVMIYARGSQILETFQVKHTGNLSIVTTSMNLVGSLIRVGTTVQETGDVVILAGYILSFLLSFAMFVQYFLYLKNTREFATKSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWJ4</accession>
    <name>A0AAD2FWJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="598" mass="67147" checksum="52AEAB560DC82822" modified="2024-05-29" version="1">MYDGDQEEDDGQQADLGLTKTAGEETWNTNFYIYRGAHTLATIPGPTHVMVDISVNHIPNNAFFQQDSLMSVALPRDLHQIGDQAFSQCHSLLAMTLSLHLESIGRLAFAECTSLTHIDFAPDSQLKSMEDGCFSGCRSLEHIQLPPSITSLGKRIFYNCTKLSTMDLSACHGLTRIGSHSFGFCSGLKTCFLPAEVTVIDTSAFGQCYELRHLHLGSLRQGGSSSQLLTIGDEAFASCRSFKSIALPRSLQKIGKLAFANCFDLITVDFAPDIQLREVGDQIFLECKRLVNIELPEPIAHSIMLKHGTFDGCTDLKERFAPIEGQANEIFLKEALSIRYGISPLHQLCYDQAHYTVEDAMSQFEKILAEDAEPLKFKSSLKTRWIDIFQMTPIHILVASSEGNPELLKAILDHCDRKMSQVGPLMMTEDLWGRLPIHLACLSDSPITMVEVLLQVHTSIDVWELEPAHWKSCIDAATYHRRELLPLLKRAHLARRIGSLGLIKWKQDIDHQIENIETEIVMASRRSISSIERTLEKYEKQETVALLRSAVWKATLLKLREQHDRIFEEQRAHCFIQSGDEIAVANILPFLGLQQQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWN1</accession>
    <name>A0AAD2FWN1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="311" mass="34780" checksum="6B428B83B800DCE5" modified="2024-05-29" version="1">MVDPNSKPGAPKPTTVLNRRRRTVPTDSSVPLYHPSIFRYTCRGKFSLDSRVSSAGVCKGIQSKLEHVDHWRLTTKDEAIRVFEHKSGEHEAPSRGPTFDQQDNNTAAAQSLELVDVSNVLVYPSNEKEEGKSSPKDGRQEKWRCYGSTEVDLLVLRPQGSKEETIAAIAPYCAPGSSVRDVSSPSLGLDRTTTIRLGVLEILYQSSLAEDDNDDPIADDERKKPVPAQTQAANPDAPRFPIRFLNSANTVMKQMKINAHTVYQATQEDFPERTMSASRRVVNEFGKTIDRTTSLMKRVIFWDWDSDSKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX25</accession>
    <name>A0AAD2FX25_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS15656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX25"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="79"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="540"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1955245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="659" mass="72969" checksum="583401194BC8C3C2" modified="2024-05-29" version="1">MAANTIAKVFPPKGDLVLEQYKAKHKDSITDPNGFWEKAAYEHLDWFEPFEEVLEGSFEHGDVRWFSGGQLNLSYNALDRQVRSEKANEIALVWEGDEPDDIRKLSYADLLRKVCQISNALTATGVKKGDVVTIYMPMIPELAMTMLACCRIGAIHSVVFAGFSAEALGQRISAAKSKFLITADIGKRGGKSIPLKKIVNDALTKGDCDEVCQHVFVWERFHKGSESEPTFEMGPKDIRMDPLVAVQRPYCPPARMDAEDSLFILYTSGSTGMPKGLLHSTGGYALYAKMTTQITFDLHPGDLFACVADCGWITGHTYVVYGPLLNGSTTFMFESTPVYPDEGRYWDMVQRHKITQFYTAPTAIRLLMRYGDLAPQKYDLSSLKVLGTVGEPINPEAWRWYYEVVGKSQCSIVDTYWQTETGGHVITNLPGVTPMKPGSCTLPFYGIDTVVLDPHTGKELTEPDDSGNFEGVMAIKQPWPGMARTCLGDHERYMTVYLKPYPGYYFTGDTVSRDSEGYHFIIGRMDDVINVSGHRIGTAEVESALVAHPAVAQAAVVGQPHDIKGQAICAFCMLTVGYEESPELVKELRMSVRTEIGAFCTPDLIVVTPSLPMTRSGKIMRRILRKIVCGETDSLGDTSTLADPSIVQTLIDKVTSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX31</accession>
    <name>A0AAD2FX31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS15671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1955275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14171" checksum="88C146268C2DC23A" modified="2024-05-29" version="1">MASLQLSKHARQMGVIGRPAMLYKKIVREIPRILMIYDIDMPLEDVRASIRTKFYEQKDIKDARIAEMLVEKGYMSLETTMLQHKQKAHLMHFLEGYTVPMEAERKRLDADASIDDQFARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ00</accession>
    <name>A0AAD2FZ00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001905">
        <property type="protein sequence ID" value="CAJ1956184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="150" mass="18103" checksum="91DA8B2797900DAB" modified="2024-05-29" version="1">MSTMKMDHIDDMIQSVQTLKLFDIESVKPTLVLVTDDNNPDKEIKNEERRTHYLTDQKNWKARKKVFDNNKRNVYGMIMKMCIDHMVDKLEREADFENKLFNDPVELLMRIKNFMTTTVDTEWEYFGLWKTMSNRINYHQKEKENIANCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZR1</accession>
    <name>A0AAD2FZR1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001970">
        <property type="protein sequence ID" value="CAJ1958332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZR1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="158" mass="18406" checksum="AEB0578C842B110D" modified="2024-05-29" version="1">MSNLINCHQKEKENIASFRKRFEERAKALQALLGDDFLDKFTEKSQEYDLLGSNAERLQHKKESWERFMANGFLYISDRAKYQSRIDGMTAQYTLKHLDFKQRCTFPTTLENAADVLNQHKHDNRKKNSNEGNSNGQGKQNKSNNNQNDGAQFLQQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZZ1</accession>
    <name>A0AAD2FZZ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZZ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="196" mass="22067" checksum="E442A646660344B2" modified="2024-05-29" version="1">MPWLNKPQGVLSSSPRALNCEYQYYYTSCRVKETKSVGPLKQFPRANQLGKKVKRVAFSDRIDVNEISPTGSLYSSAANGIWWSQEDYSKMLLITKLARDNDRSSEVCMVGLEACSGSEYQKRKERKIRVISAVLTAQKNQKLEGITDPVYIAALSRSFTSASVEEAYLRASDGTAIELLRVEENITDQDLVEIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZZ7</accession>
    <name>A0AAD2FZZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="4">EF-Ts</shortName>
            <shortName evidence="4">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS17280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZZ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14275">
        <property type="entry name" value="UBA_EF-Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.20:FF:000001">
        <property type="entry name" value="Elongation factor Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000001">
        <property type="entry name" value="Elongation factor Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042213360" description="Elongation factor Ts, mitochondrial" evidence="6">
        <location>
            <begin position="17"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="7">
        <location>
            <begin position="107"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1958646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="328" mass="34812" checksum="F3CA6F42FA80256D" modified="2024-05-29" version="1">MKFTGLLFFALGTTSAFVQPSHPVVGKYSGLSTNLFMGDVTPKTIKQLRDATGAGMMDCKKALLESDGDQEAAANELRKKGLAKADKKASRIAAEGKIVASSGPGKGVMIEVNCETDFVAKDGSFLAFCDKVAGAAVGMSDDSVETLMAEEVDGESLETTRQAMVAKIGENIQVRRMASRGTADSTVGAYIHMNRIGVLVEIEGGDEALCTDIAMHVAAMNPPFATADEVPAEVLEKEKKILTEQALESGKPAEIVEKMVEGRIRKYLEEICLVSQNYVRDSGITVGKLLEDNGAKMIGFTRIAVGEGIEKKEDDFAAEVAKMAAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G035</accession>
    <name>A0AAD2G035_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS17411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G035"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042289131" description="Sugar phosphate transporter domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="94"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1958906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="401" mass="43221" checksum="676FA1C2D2A92FCD" modified="2024-05-29" version="1">MQRLSCLCVLLLGALIHQTTAFASQRKSIAFPLQQRNHAAPSTGTIIIQPSTVKVVHDSSSRTSLSASMSDGTPLQQSRRAQVAKLKRKKMINTSYLFIMWYVFSVLYNIFSKAALNLAPDLAWTTATLQMSLGLLYVIPLWLTGLRKKPDISPKDTVRLLPVAILHSLVHIGGVVSMGAGAVSFTYIVKASEPAVSAILSALTGNILPLSVYATLIPVMGGVAIASVSELSFTWKSFNYAFLSNLASAGRGIVGKKTIAKRLGNSMTASNLYALLTMLATIMLIPVALFMEGSVLKSAMKSLAAVDKRGAYFLQTFGASLTYYLYNEVSFLALDNVSPISHALGNTLKRVFIIISSMFVFGNRMTGQGWIGSTMAVGGVFLYSVEKTRQAKLTKAKGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0I5</accession>
    <name>A0AAD2G0I5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001981">
        <property type="protein sequence ID" value="CAJ1959191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0I5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="573" mass="61749" checksum="A8C29F4A93B6EDCF" modified="2024-05-29" version="1">MDDSMDCSDFKTASPAKTFNSPPVAKRRRLDNIAEDNNDEKKAPSSSCTDHSSRLIVNTCLNQIANADKLLLVNLFMENLESFLQDGSGTTMGSNDPKGQQFVDTFLTLDGCSVILHTLKRWVDAGTHKNNTIDEETAAFVSTALGFLVHTMAYNRRAAFRFLDVKGLHITQLLMQICQSAPFDTVVLGRAISIWGKLMTNVTRREDVLVENFSNLILNIMHLHPQCERIQRYGCKFFASLATTSQNSGETQDFDRQKLRQVVELALLSYRNKERTYYWCRQCTALYSAGQLVRHDDGNTSCSTDSSRNSSRASSDTLSQKSSQNFAAGQDLVLNRDLNRDLNRDDGEVTDSSQNSSQKSSDGKLDGDDDGDTGSGTDSSRNSSRDSSSDTLSSRNSSSGGEMVRGVEVTNASQSSSRDGSAAPVVSADGGNTSSGTDSSQHSSARKLARDDDGNTSSGTDSSSRNSSRGSSDTLSQNSSQKSSARKVARGGECTDSSQKSSAGKLFSVDGGSTSTDSSQHSAQKSSAGRDDDGNTSSSTNSSQKLSAANLNQLDQLDQMARDDDGNTSTDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0M9</accession>
    <name>A0AAD2G0M9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001985">
        <property type="protein sequence ID" value="CAJ1959272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0M9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="638" mass="68737" checksum="AA109E2CD72F028F" modified="2024-05-29" version="1">MAAATAPTAPTVAAPTAPTAAPAAPTPQLTAYHEFFGNTTLDPHQQDYQALMRAYRVYDTPTPAQSLYNSAGLSTSAYPMVYLSLINENGNLFYLLVHAPAFYKSLPGVPSRCDGKAYAFTGDVAANTITTIEFPQDAFMSPGTGTEENVPKDLERALDILQLNPDDSSIGPFQDTDANIKQAKTRHYIPLPHHYVHLVLGRHVPVRKGFIDLAAAIKNTGDKIECPELTDWLLLSLVRAGAGAPPTLATTLPDRPFDDAALKVQRRELLEQHLPGLKEASLPSMLGIQQSLAQSVNELVRTQKDAQTEATAREAKAKAPRSVDEFFGPMLHKLLSILHVQDTSQSQGSSEATGGFGIVPIVTPDLVKKVKAVKLGGNNTDNLEEGIHPFSIVLPSYGGSDVGVTKAARERAAAYAEVHGGSGASLQDAIALRKPTVHIPDTFSKAQSHLMGLLTLWQIRQRSDSWIAALPANYRSEPAAQLPTAPWNRGYLPYMMPPDMVPMASDSSGASSLTPHSLGYPPFFNGFFPPQGGGIKPGEDDPKSKGKNSLQVKNSTHVPELTQFRKLALATAVSKAEQKAGSPPPEITHNGTKVQMCVGYHVKGKCWEKCPRAADHVAHSAQDTAKLVEWCKKAYAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G139</accession>
    <name>A0AAD2G139_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">XTP/dITP diphosphatase</fullName>
            <ecNumber evidence="10">3.6.1.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS17264</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G139"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042000465" description="XTP/dITP diphosphatase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1958614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="267" mass="28601" checksum="3CCDD8E48015C999" modified="2024-05-29" version="1">MTSRIKSIKSQNRTVILAVLILGCICASVDSFAAPSTTVNGAGQLNIAFVTGNAMKVREVEMILSEQGSTNGTHPGSGLVNLRVVKVDLPEIQEVNTEAIAKEKALLGAQLAGGPCLVEDTSLKFHALGGMPGPYIKWFQDRLKSDGLYKILTAYEDKSATAVCTLAFCPAPHADPILFTGECSGTIVAPTGKGGFGWDSIFVPDGEEETFSCLSTERKNQLSHRGDAVRQWARWLSANQEALMLRQDGIPAIGHKGLDFKSYSAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2P6</accession>
    <name>A0AAD2G2P6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2P6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="327" mass="37033" checksum="3D53CBD4CCB15A2A" modified="2024-05-29" version="1">MKTDSPPKMRERSPSVDEDLRGAKPVFEHEQKCQEDHTPMKPRRQISGTPSQFRFFSDHEMPYDGPAADHTSVLSGISDPTGFGSLDSSWRSFGFDTSSRLEVLGPLRENVDESYSFNVPPQKLVSSSYMMHHTSREPSTKDMPPQPVCDRDEGTRVENDADTFGSGVKYHDDSPAFPVLLSGEECADPLKAACSIRNDPKLAYMEGAIDCGDNGFFCTVTEQDDWEPRELLDNLNFGYCNRTKAFDGTEFQDDGHCHGSDDDSAYYWVLRDHWFRQYNGRLRCCCNWDSEEVDDDDPLSNGLFTCQSLLWLYTAVGFPNAEQQCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3H4</accession>
    <name>A0AAD2G3H4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase-like protein LARGE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS19195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3H4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF52">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN GNT13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1961435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53737" checksum="E714F10300783E15" modified="2024-05-29" version="1">MPLQLCQFRNQNPETKTRKLSSIHITDNDQRQEYYDTLNGSLKIDMSSLFNKCNHVSRAIALLACCVLWSIFIHGGVAFQRPNQEGSTDLELLYEKLHGANQRIKELESGLIHNGSAQHSMRLSSLPGNLTLGDKNLLPRFSAAKILFESLPFSESTFAKPLVLRNFIRREQLLNKTTIVLSTQTSTRKFDSLYQQLFYWNGPSSIAIYIKSEKDLLQLANFTSENTELLKEASFHLVMEKTNLPYPANILRNVAMEGIESFYFVAMDVDLIPLPKNCHSKLSLTMSRLSIANRTKTLFVLPAFSLLPEKKGTFANASEVPKTKRKAVAMARRGRIEQFWRRKFPQGHAPSRYPAWMKAGDDSKDFYRVTMTKTQSKSYEPYVLGFKPGVPRYWEDFRGFGRNKISFFTECYRAGYTYAVLTQFFCIHLDHPAIEPTVKKEQNMASLKVWKKFHNEYLNPKYGKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3X0</accession>
    <name>A0AAD2G3X0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3X0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1961443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="186" mass="20779" checksum="51151D19AF179027" modified="2024-05-29" version="1">MNKSVEVVEILHLDDFTASEIAASWYDEEEMKEITQGCFKVLQRMEYGGTKKGKKYCTRGLEGHTTLGSISKKETRTASFVAVLDEQEKQWNENKDFDFQAISDAYRKVSSSSQLWAQVIGNRDHQAIEAYLYQDEEEDEEVQATTTAVSIKSAKSVFKSPVSQTKPLNMEGAAGVVVHQAVARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4Q7</accession>
    <name>A0AAD2G4Q7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002095">
        <property type="protein sequence ID" value="CAJ1962173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1154"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1438"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1518"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1574"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1602"/>
            <end position="1613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1962173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2258" mass="254419" checksum="D1E846B7C8AD7121" modified="2024-05-29" version="1">MSSTSGGTPSTGTLPSYITKPTCGGITTVGPNEYEIYTGGKPDDTRSGLDSSAPTERVYPGQTRPISGYRSMKSQTYRTTFEGTTKISKTSQQTKLKRDLHQHFVENGLDSITYLPDANGATTSVILSADSFSQETALAAYKTMLPKYDKYCIANDKDAAKYLLNAVDDDLKDTIELFHTESDGFIAVWFSLLANITDNNIDRKKSLEDEIKSITVSQFPQQNLKSMVAKLKPICDELDAMESYEPDNSIHMLDNFSYAGSGTDPSNPHTMRFRSKIITLRDKLDDAITTCRNMSKATRDTHLKGQGLHYTQLLKTISDIYVKLEHNKTWPPSMTPLDSRTPAALNMAALKDSLSPSVAAQFEAYILQQSKGRQPPDEDKKSTNPKHVPPTPSMTPTETIEGIKHYVQDIKGVKNNWCGRCRRWTPTHWTWMHGRKPDDKPTPVTPASTESHLLINKQDSSGSDDDTSLETNLASSGFKYVFYHMELPRPTPAKISERISSPEILDEAPSSSIMDKSYLWSYLWYTFQVAILGFSLFGALLCTTTTIDALPGLSALSAFFQDIPRLVDTYTFTWHAIAPLLWYLIYSLLFIGPDRFAAPTPVPRHIRRQIQRHLFRESRRKPRGIQKPSFRHPRYQPSRADCIRRFHATTTFFPSSFHTVSEGENGEIPVYRRHIHVSYTRPQARTRPTKFSLRSKWKSPMERKLRQWMLDYSFRSYHKKRIQKLRQRAKQHEKLRQRAKQHEKAMKETRKEQANAESIRLQQLRSQRTSELLLQGSLDPILPPFDVWDTDSWDNYTTPPDDYCVESSTCQECSLSDDESTNYSTNSSTSHASTSDETTANPPSIIHLYPVMIGSSVAEYANDHLFLTDHCAKDLEPAFPVIWDSGASVCVSPHLDDFVGPLGPPPCSSTKGVGGPVEVKGTGNVKWTFRTTDNSFRTIILPAVHIPTATQRLLSTSSLCQKYPNETLTQNADGMILSGEVPITRAVQASIDNSNNLPTSWSFRHVTKPINDNTTSDDATVCANNISSDQSSPTPTDCCLKRSSSTRPSHHATMQAAISEVCNHNINLNNGDREWLKWHQRLGHRSFALIRYIMGAGTLAKSQRARALHTQVSKRVECPKCAACCYAKAKRRSPPKLRRSQGHIKDIPSTLRDNTLYPGQEVSVDHLVSSVPGRTYEGFGKGHKSTMFKGSALFVDNATGYTYTHHQRSLNTHDTLRGKEAFEANCRDLGVVVQRYRSDNAAVFHSHEYKLHLESFSQTQKYAGVGQHHANGIVEKSIQDIQSTARTMLVHLAIHWPEQADLALWPMAIDHAVFLHNHLPDQTTGLSPMDKFSRQRWPHSKYHDIHVFGCPTYVLDKKLADGKTIPKFKPRSERHVYLGFSPFHASTVPLVLNPRTGSITPQFNCVFDDWFATIATSIEEIPTFLEEHWQTLFTDSEYQFPADDTDPPALATIPVQPPPPPASPLDTFDSASSPYITGLPDLFEPRSPPSTSNIPSVPTSQSSLERERVPVAPMQATPPLNSTTDSSNQREPELPSQQQREQQAPLPRPTPRNKPNVRSQPPLPRERPIEDLPSTHQFSPNLRRSTRSTKGVSAPILDPDPSQKSYSSKVEYSSHLSELDQSINPDFNDVENLHSFPKDTPFLTAEELVLTPKHESYKRFSTQPDTDDGGIAGFYDLHFSYLGYKLEDKPNFVFMDSRAPADVIEFLKAASSDPDILTWDEAMKHPEEAEQWRKAALKEIRALEHKRTWLEAPESNATVRVIPGTWVFRRKRLPDGTITKFKARWVLRGDLQDLDMDTRADVVAWSSVRIFMVLSLKLGWVMKSIDFTNAFLHAPLPKELPMFAHLPRGFYSNMRSITGERTVLNLQKSCYGTTVAPRLWFEHVMKAFKELGFESSPYDKCFLIRKDMMIVVYVDDCGISCDKPEKIDELVQQLRDKGFDLEIEGDFETFLGVEIEKLDDGRFHLKQTGLIAKVLEAAGLSDCNDNHVPAGPTPLGKDETGEDWPQHPWKYSSIIGMLIYLCTNTRPDISYAVSCAARFNAKPKACHATAVKTILRYLKKTSDKGLIIEFDGTLDLEAYCDADFAGLHKSEDSFDPASAKSRGGYIIFFGGVPLLWKSSLLSCITLSTLEAEYMQLSRTMTVLLGIKNTLEDLLPPLGLQTSNRSITSTVFEDNAGALLLATEQRITPRTRQLLAKWHHFWSWIRKPSDGPPRDANSTWDDGKITAKKISTELQRADMFTKGLTRVLFERNRKMICGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4Z3</accession>
    <name>A0AAD2G4Z3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS20027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002136">
        <property type="protein sequence ID" value="CAJ1963152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4Z3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1963152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="194" mass="21445" checksum="9A52007FE20AB142" modified="2024-05-29" version="1">MDNIANCTEIDYDLNSDDMSVFSFVENVEEAGASGEDHDNVRFSGLRPCMETKTISVPFKVDDGFAAPVSDEEESLSDNSLFSDISFHPVADDKEGIPSMEALVAKLNRSMLRSARSRAMVSKTVFPDLRKRGTNRRVNTTPVDSPSSSIKTILHRGPRMICKTPSSSICIAQCDAMKIDGNSIGDFLRQTKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G521</accession>
    <name>A0AAD2G521_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">formate C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CYCCA115_LOCUS19965</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>formate + acetyl-CoA = pyruvate + CoA</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1963009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G521"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050244">
        <property type="entry name" value="Auton_GlycylRad_Cofactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30191">
        <property type="entry name" value="FORMATE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30191:SF0">
        <property type="entry name" value="FORMATE ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01066">
        <property type="entry name" value="organic_radical-activating_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0556">Organic radical</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="20">
        <location>
            <begin position="61"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="19">
        <location>
            <begin position="697"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="21">
        <location>
            <begin position="869"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="17">
        <location>
            <position position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAJ1963009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123627" checksum="CFBF0FA4C4EEAA0A" modified="2024-05-29" version="1">MFRPTSVATHKMRLSYSEESRNLKPTPRNNHGSLPSFKHSFDDLAAAMVGDAAASKQSIEEKIHSLQDLPVVDTPASLPGDCNVKDYVLENVTPYDGDDSFLAKATERTLKSWARCEELMELERQKGILDVDTKTVSTIVSHGPGYVLSKEEDVIAGLQTDAPLKRSCKPKGGFSVVKKALESYGYKADPAMAKTYTQDVQTHNDMVFSMYTKEMRAARHTHLLTGLPDAYGRGRIIGDYRRLALYGVDELIRRKKLDYDAIKGSSADNLLLRSEISKQVKGLKELVTMCDSYGVDVRQPAKTFREAAQFMWLGHNAALKEQDGAAMSVGRWDAFLDIFAERDLADGTATEDDLQEVIDDLVIKMRLVRHLRPPAYNALFSGDPTWLTLALGGCNEQGNSIVTKTTFRFLHTLTNLGASPEPNITVLWSLNLPDTFKDYCARMSINTSSLQYENDDMMRAIFGCDYGIACCVSGMRIGVDMQFFGARTNMVKLLLMCLNGGRDELHGDKMCPALEEECKKLGIGAGDEDRPINFEDIERLYFEIAIPWMAELYAETMNCIHYSHDRTCYENVQMALHNSNVNRLMAFGCAGLSVVADSLAAMKYDEIYPIRDEDGLTIGFRRGHPNREIPQFGNDDDRVDSLAVKVCSRLHEELDKQPLYRDAKATLSILTITSNLVYGKATGATPDGRVQGEAFAPGGNPMHGRDKNGALASLASVAKIPYSKCMDGISNTFCLLPNALGRREATRSANLATLMDGYFAHRGHHININVLRREVLQDAHLHPEKYPNLTIRVSGYAVRFNRLTPEQREEVMARTMHSATTVTMAKKEDDHDRYAAGEDEEVKLDELEGIEEGDAQLGSVYSLETFSTTDGPGIRTNIFLQGCPKKCLFCCNPETQALANPKKHPEFAMSSAEIGSLLEKYQEWLKPRGGGVTMSGGEAMLQPMFVADVFQRARNLGISTCLDTACYGNKRRWNQILPVTDNVLLCMKGMDNEIAAKVAQAPAHEMAKSKEFARYIHSDYPNIKITLRWVILKGMTDSESELKLLSEFALELGDSLHAIELIPYHELGKDKYASLDMAYPLEDMPAYKHEDAVAVQQTLEDAGVRVILSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5A3</accession>
    <name>A0AAD2G5A3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS20199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002147">
        <property type="protein sequence ID" value="CAJ1963512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5A3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="571"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="794"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1963512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1183" mass="133854" checksum="AFEFEEBFDC11618E" modified="2024-05-29" version="1">MIEKRSKAESIETTSKEDVSYDLSSNNDKPKGTHNTTTAELLQNDPKVKRIRKIAIVVLLTAAVGVSGGIYTSLVRSEEREFQNRFEDQAKQIGQALEAELDNKLRAIDALSVTITSFAGSQSVQWPNITVPEFSYRAASALSLGRALSVALYPIVSYDQMRQWEIFSVQNQQWVKEVVAFQAKFPQAFRSSVKKEHNMDASRAERHMVTNSSELLHNISDVIFHFDDDGMPTRISNELMLPMWQHAPVHPGLPRTNYDAYAVERNREALDKVMQNQASVLGQSYTLEESCYGHDFPPMSPDLETETWDDIWTQMVAMKNNHQHGHSGHTEIMDHSGHIELNHNHHEVAGLEGPAVNLFYPVFSDLNENRTVVSILALTSKWDSFLLPSLPPDPNGLMVTMNNECGQSFTFEITGEEVIYLGPGDHHEAKYGSFEKRFPLTLDSSVFTEVPMANEYCTYTASVYPSSQMREEFASNSPMIYTVSVAVIFFFTIFVFVFYDYLVQARQRYLVETASKSNAIISSLFPQIVRDRLMEGEGQNARKKIWRTEAVNGGAEKPAGPPIANFFANTTVMFGDIAGFTAWSSSRQPSEVFALLESLYGKMDSIAREMKVFKVETIGDCYVAVTGLPNPQEDHHLRMVKFATRVLKSMGPLTRQMEVKLGPGTTKLGFRVGLHSGPVTAGVLRGEKSRFQLFGDTMNMASRMESTGKINFIQVSNATARLIVASGKDHWISKREDMVEVKGKGTVQTYWVTDICAQRRQSNDKSTCESSASERRSMDTLCSKDQDAIAKNNTRRSLVEWQVELLSQLIKQIVAKRKDSPRKSLQPFNGWDSKHATPRDEIVEELHLPSLKPGTTTNQDSNRVKLSQKVQDQLHDFVTSIAMLYRDNGFHNYEHACHVTMSANKFLMRVVNPQGNGFEDSLRASLRAFHNHEYAYGLTGDPLTQFAIIFSALIHDIDHQGVSNKQLSEEDSRLAMMYNGKSPAEQNSIDLAFEVLGSSQYHDLVSCICANEEELKRFRQLVVNCVMATDIFDKDLLAIRNKKWKKAFKSEEEESSSDLKATIVIEHIIQAADVAHTMQHWHVYQKWNEKLFFEMCTAHEADRGPAKDPALGWYEGELWFFDNYVIPLAKKLEECGVFGVSSDECLNYALENRKEWEIRGRDLVTSMKERYAKMRKEGKRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7M1</accession>
    <name>A0AAD2G7M1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7M1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34660">
        <property type="entry name" value="MYB-LIKE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34660:SF3">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="784"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="840" mass="90771" checksum="58CEB2B56AE7FDFF" modified="2024-05-29" version="1">MGIFRFTEETTTATYEFERMTWDEMDEIFWTEEEVGDFRNFAFMVDCELEEEDWSGPDVEPLPWNKEIDEKKFEKFESNLNELKAKRKREMESFAASGNLPSAHVKPEYYALEDIENHPVKAPPGEAPPTKKTKMDEEDVKEEEIETSNQTQEEPVAEESLEAQPQPQPDSEESEPEPEPEEPTIEEEPVAEEEPKGEEEPSEVAEEPSDVAEEEPSEAAEEASSVNLEEAVAESDPPAKPQPKVEEAVVDKKPEKKKSKKKKDKTEKEQVQVSEATEEEAKKKKKSKKKKDKTEEEKEQVVEATEEEAKKKKSKKKKAKTEEEKEQVSKPKQAGKSEKKKTKKKKTKTEEEKEQVSKTIEAETKPEILEEEIQPKLEPETKAEEEQAEIAEPAKDEIEKPNPEILEEETQPGTEPETMVEEKQAETAESSTDEFTVVTESSEAESETESELNSSERSTSKRESGMKKSRLGRFAGKTAGAVVGTVKGGAKAGVKVTTSTAKFGAKTFQSGAKMGVGAVKGGVSTVKAGADAVGVTTVVSAGAKTFQSGAKMGVKTVKSGADAVGVTTVVNAGTNAVKAGAKVGTSAVQSGVKVVGAGADAFANTTIVKAGTSGIKAGADAVGVTTVVKAGTSAVKAGTTAFVAGATYVTGMLIPKRKIMVTNDTTGSENKVKKLVRPPRAQRAPQQEYQPIEEEPPEAESNAGDPEAAPIAENVEAEKTEEAPPKPESNAEGQEDGGSKRIETENVEEAPPKPESNTEGQEDAGAEKIEEAPASPSKPPKSPKSPGRSGRSKSPARLSKKGSARKSKTKKSDDSKSEKKIEKSPSKRKSKKPSSSAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G809</accession>
    <name>A0AAD2G809_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G809"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="82"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="341" mass="38967" checksum="1BD816E362B1E624" modified="2024-05-29" version="1">MGIFKKKTNKSENPPPEASKAATEEEEFDSKEIEACRSDGGGINIVVNKPDDSAAGVEKERELSHPSLVSLYIKDVDANNDIPANCSPVRISNEWFDMDMVVMLRTPNVDDDTSPKGTEWNQKVADYFRPKQRRFEFQYQVKLKKKPEDKELFYAIQWNEPVKLGIIQRTFLAAILAFLKRTRPTVHYSTTGTEKKEDGSFEKPHLANFIEIGLDRVVITKPGEEPPALGGDIEEDLDHYKARKSGKVKIDFNTEDTYTFALWNANVDWIDWKIVGIPGVGSLDLNKFLGNQPLSILLYMLDKNRGNTNHFQKDQELIVHLEMSSIFQHKDKEEKKKGGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8I9</accession>
    <name>A0AAD2G8I9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002203">
        <property type="protein sequence ID" value="CAJ1965599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8I9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="81"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="143" mass="17374" checksum="7FEF1CB795D153FA" modified="2024-05-29" version="1">MLPKGSKLRGWYEKYDELVEFWKEHGHFVLPVKPQFSTLQGWINTQRGKKIGGALGSVVRKSHDYLLDRIGFPWRSDRIEFDWQLWYNELVQFWKEHGHLEVKHTENLPLYDWMIRQRQNYKGTGVKLTDHQMEELEKIGFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8K0</accession>
    <name>A0AAD2G8K0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002277">
        <property type="protein sequence ID" value="CAJ1966329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8K0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF498">
        <property type="entry name" value="DNAK FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="51"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="571" mass="64801" checksum="C28D31B3E42CD1C2" modified="2024-05-29" version="1">MYGFEIPKDYKDALRLGKLHGNTKWQDATKVKMDQLADYKVFIDLGRGTPIPKGYQKIRVHLVYACKHDGRHKARLVADGHLTDVPLDSVYSGVVSIRGLKMMIFLAELNGLELWATDIGNAYLEAYTKEKVAIIAGPEFGPLQGHTLIVSRALYGLRLSGKMWHQRFSACLEEEGFFPCKAEPDIWMRPTTDGSSYEYVGVYVDDLAMAMKDPQAFVDKLIKVYKFKLKGTGPLEFHLGCDFYRDKHGVLCMHPKKYIDRMVDSYQRMFGQRPKTNVWSPLEKGDHPECDTSELLDSEGVTQYQSLVGQFQWAVSLGRLDVTTAVMTLSSFRSAPRVGHLNRAKRVCGYLVKFKEACIRFRTGLPDYSDVPEPAFDWADSVYGCPTEEIPRDAPPPLGLAVILTHYVDANLYHCLLTGRSVTGIIHMMNGTPIDFFSKKQSTVETATYGSEFVAARTCVEQIMDLRQTLRYLGVPVKGRSYMFGDNESVVNSSSRPEAKLHKRHVLHKRHVALSFHRVREEVAFNMLSFIHIDSVLNPADILSKHWGHQQIWPLLRTLMFWSGDTADQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8U1</accession>
    <name>A0AAD2G8U1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8U1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008479">
        <property type="entry name" value="DUF760"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33598">
        <property type="entry name" value="OS02G0833400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33598:SF4">
        <property type="entry name" value="OS02G0833400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05542">
        <property type="entry name" value="DUF760"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="449" mass="49036" checksum="8EF3DD22F9F6A0A7" modified="2024-05-29" version="1">MTRATEYPQTKGYSRNTICTALLAAIAVLKIPENAKVTAFQQINVVTPFQTRQSIITQRFSSVGDGAIPPEDPEEGGGGDLDGFLNPKKESDNLKKAREFMSESSLPLSYDEDDETNDEADGIDKVPLDHKSSALVGAFGSSSSSSLFADEASMDAQLAKNPYMQVVSKLSPSEIISKFTATANPRVQEAVRSTILGLIGSLPKMAFETTTITTGQRLASLMFQLQMTGYMFKNAEYRLSLSQSLGINPIDTTHMLSGDPTVQLEDIQEKIMSGKIKGKLKVRMGKKPESDKALPSTDTINDPNEIEVDAAAYMSELRSEVSKLKEELKEHEDAKEEELRKDLLLYIRTLPAQELKELTNTMSQDVLVCMKGLVQAVLAGIGDGKIAPDTVTEQSGEAMAQLCMWQLAVGYNLRELEVREELKNKLTGGMGNASDDENGIDFSQPGILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8V5</accession>
    <name>A0AAD2G8V5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8V5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="650"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="680" mass="77320" checksum="786D94DF1E375F7D" modified="2024-05-29" version="1">MNALNDSIFDDTSTDGSILQQPQQQQQHDHQQQNEQRQQQQQQEPPQDMGLLFELIESREWEGVISFCNQVPDAASIGRVYAEDILNLPLHEVLKQPHPSWTVINLLLNMYPEGIAKKGYQGNLPLHYACSNETISIEILQGLLEAYPTATRLRNDEDSLPIHLACQHLSELDSILAILQTHPEGAYLRDADGFTALDYASASSNIGTSMNTTLEQMAPILVETAKAAAERKSEETNQKIKGIQEAHEEYIRQLGFREEDLEQEFMEAQIDLQDQLSEEKERNISLAERILKKERTLQDLQTQVDQLTNMIKDERVDRQLEMAKQQQEYKEILGINTVSNNENGSAAEQASSPSARSLVSLRSASPSTSKSPIRTSKNVDMKTHLSTLVQRYNLQQKELAEMAKDLTYNTNMVRNLNELLTSKDEHIGELKQENFDLKQEKQAQQTQNDGLQNSLQATQDELLDAKQEVQRLSKMYEQQSEQLTEANRIVRVQESRLASIKSLAQSLSFNIESWDLDDQQKEGEAETWGHQPQIQQRPQSQPQPRRSQLPEQQPQDQLQEEQDQLQPSPTDEDQHISSRFEVLEGMETIRQNDQYDHHGGNHNALMKQGRMSPMPNNKQQQQQALMMADDKEDYSLKTNETGLSTRNEESTLPSSPGEESSSLSSPARPPMGATRQTSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G989</accession>
    <name>A0AAD2G989_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS22171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G989"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="5">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="5">
        <location>
            <begin position="190"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="5">
        <location>
            <begin position="345"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="5">
        <location>
            <begin position="521"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1966586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="920" mass="99273" checksum="3EDF771BAA356ED3" modified="2024-05-29" version="1">MSAPTILPSRGVARVKNVLSGDTVVLTGKPTATGTAPEVTFTLESVLSPRLASKGNGNVDEPGSFDAREWLRRLVAGKMVQFETVKQGASAGDRVYGLLMFTPPGTAQPINIAVEAVRNGNATPKNTVLDDNSEDADEYKKALKSAYQEAKTASIGIHSSSPLVRKLKTSGDDFEASALVQKSKKHGNHGKIKCIIEYIFDGNRFRMQVVDPAMGDLQYASFTLFLAGVSCPRLGNSRADPPTPPEEFAEKARDFVELRLLQRELDISLHGTDKSGSTIVGTIHHPKGNIAVELLKNGFAKMSDWTARMMNPADVPALRIAETNSKRTKTGLWHSYQPPKLSGAAQISGIVVEVLSGDTLYILPDGQLYDSETKLVKVSLASVRAPRAGNRSGRADENYSYECKDRLRSLTVGKPCKVQVHYEREIPMGDKPEKRQFGTVAVKNKADVGEVLISEGLATTQFHRDGEETSPRYDDLRAAEAVAKAAKVGLHSDAEYSRTPTNDLTDPKKAKAYSGALMRAGKIKAVVEYCFNGARYKLFVPAENCHIVFAVANLRCPQPSPVGSRQTKAAEPFGDASKRHARMTVLQRTVDIACTGVTNGGVVTGNITVGSGAQERDFAMELVGAGLATVDQRKIDYGEAPPQLVDAQIAAKSNRMGVWSVEQQPTAAVQTKTNDSVSEQVASIRVSEIRSAAHFFYHIVNDDTVKVIEESMKLFTTNNGTGGAPCDVKVHKVVAALFDDGSGKSWYRAKIVEKLSPEKVTIVFIDHGNVATVPVATHLRPLDDSLLPDKIPAVAKEACLALALARPLTDDYGIDGAKMFQSICWGKDIVARIHGTDESGKVVTSIVTESGETANTQLVAAGLARVFKPSSAKALASRMVDGSSIMKLAAELNVAQENARRSRSGMWRYGDIGEDDDDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9D4</accession>
    <name>A0AAD2G9D4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9D4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="573" mass="65034" checksum="EB8188CE00CD1778" modified="2024-05-29" version="1">MGQQQSQDIGEMPKLKPGGRRRGRRNMGQKMSSFVRSNSSRFNVHGDDEVEHLDEKIKIYKKELERLVAFGEAKQQEHHAELGKMDNELYRKRVELHRLGESAKVFFTFWDYVKIVQRATPTVWSPETMTFIESESDTSESSYTTDDLTPVPPSPKAPRGKSPRTRTKKSPGRPKRKESLRKKRQFSRKEEKRGMIISRSSTDMTFTIFGFFEAYLLRRLHLALLLKNQSTMQRHRWNDIIVYCYDEIPATKRDTEQAKAWLDYLKTVTPNYKKQLKETFEHFLALQDKLMYQLRAPEDRPKELEAQNAFHTIEEAPLDDEITRTLPTITQTSSGTIDFEDQDDAPTSAFSYKIPAEEAALPSAPPPQVEGRIYATSEFNTGTTGMTPEVRSRKSKTKPRKRKSGNLKVSAHNRVFESKSGSSDSGSDFGSSDDDLGDNSGKEKEKAAKNNDVKEKDTGKRRSKWSMSWKVPALDSDSDHASGDELKMSADNSAVGNEYGRLSMRDDDDNDDDRFDFVSQEANQQPMASSALAGGASMMLMQKSIRAQQTQSKPDSQQHFQLNTAGSDDAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9G5</accession>
    <name>A0AAD2G9G5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS21784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002264">
        <property type="protein sequence ID" value="CAJ1966201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9G5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1966201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="215" mass="22882" checksum="098CFE2ED6EA8791" modified="2024-05-29" version="1">MSQKNREGEVLTGTTILALPFEGGVVVCADSRTSTGTYVANRVSDKLVQLSDYIYCCRSGSAADTQALTDYVHYYLSQWSLDTGRIPTVKTAAHLMRRLIYQNKDQLQAGVIVAGWDPVHGGSVYTITLGGSCLELPFATGGSGSIFIAGLLDAEFSNGMDMAEARNLAKKACSHAMCRDGSSGGVIRTVVISADGVDRDYTPGNDLPFGPVAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9R7</accession>
    <name>A0AAD2G9R7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002310">
        <property type="protein sequence ID" value="CAJ1966654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9R7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="67" mass="7418" checksum="33056A8FD6072C43" modified="2024-05-29" version="1">MEGLYNTTLASCIASEDDILYDPGDSQDLERSETSLHCVRDSINIETYRTVNLDISNTSSCGSCRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAL8</accession>
    <name>A0AAD2GAL8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanylate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS22401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAL8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="262"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="685"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="850"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="735"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1966818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="970" mass="109924" checksum="E5B54F6935622183" modified="2024-05-29" version="1">MAGVGEGAIVDRLRRYGITKMDKKRTVPLERLRNAPLHVRTQVEDVHRWLFVEGGHYEDIESLMTNYCHFVRDNLQIPLDRLYFGGVGLHPKLTSYLWKWELDSFEHREMPQEIFERRNELFSPDEPFCVLEQGRAEFIRIRSSDNYIPPDTEKWFRAGNYADYFALPDIHRGEFEGGLAWSTKHPKGFDDEYVQFFELTQPALSTVIRLHMNALVIKTLTERMEREIEERTSQLATANRELEKASEEISRNAAKQLEHFACMSHEIRTPLNCIVGFSSLMLEKSDQMTAENEESIRMIHENGNLLKCVVDDVLDYAKLESGCFMVNVQPCELHPTISSVVTSIAQKAKKRNVTVRTDYSAELSGIMETDNRRLQQVLFNLLGNAEKFSKDGGVIDFSVSLVGYDEWRYEIERNEQMLCYGEKFDNKEKLRVISFSVKDYGKGIDKKDFETVFEPFSQASKETQSIYGGTGLGLSITSKLVKKLGGFISLDSEPGKFTEFCVYFPFRGGAVDVAGLSKEFTDTTVVLVAKHLGIPISGSNENDSVSISFEVARTYGLDMLRCLDWDDLDAKLSESVSLRSYVAIIADSSDVDYSKYTKAESKIGSSRCALFTCGNTNHTEMYGGFHLGFMSASFPVTVLQRIWSQMLLKKDNTKPRLKLQDSESPSSVVEKKERLLTRKDFQRLQILYADDNGINCKLLHKMISNLGVTNIDLVNDGTKAVEYAECTSYDVIFLDMEMRVMGGIEACQRITEFDPAANIVFVTAHVSEKYFKLAKDAGAKDYITKPFDLKMIRNVLKKSIYRDCMDTSMPLATKQIETSRKATSFSRAQSMPLGLALLSSELKPLASDLKVLYADDNMINQKVLRKVLQRLGVENVDLVDNGQKAVEKANENRYDIIFMDLQMPVMDGLEASKHILEEDPAAVIIVVTAHALHNFIETAAFTGCSDFISKPVNLKKIQSVLEPYTIFDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD36</accession>
    <name>A0AAD2GD36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002480">
        <property type="protein sequence ID" value="CAJ1970228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="46145" checksum="A16E3060ED19E317" modified="2024-05-29" version="1">MTSFKQCQSRHCCLGLISFLVVILVLFLVTLQRKDVTLRRVAEEWWEPKPFLSKASSSSSSSSPPPSSHDRKRCPPLDPMIEQDFVGFPQNLTFGKYVAEQGRPFLTHDFWATIVDNRRTFLLRSFEAGFPSDDKLRAWIRSRPHPITLIINNNLDQSWPNEDGLVNKTSYQIILNDTNVHAVYASNARYLSDYPKLQPMPIGLKWAYKSTLLFGEPKDERAQNYRTYGASGPDQSKALFFSKKRKSTVFWRPMQARSNAATTKYVRDTPALQAPRSSIPPIVKETAQNSMVFAPAHMPQEDFFGELKKHRFVISPPGNGLDTHATWEALLCGCIPIVPRSDLDRVFDDLPVWLVDSWEEVTDASVKEKEAYFLANHEKWNWEKLYQPYWKERIHEGLCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JG87</accession>
    <name>A0AAD2JG87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiaminase-2/PQQC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JG87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19358">
        <property type="entry name" value="TenA_E_Spr0628-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026285">
        <property type="entry name" value="TenA_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050967">
        <property type="entry name" value="Thiamine_Salvage_TenA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43198">
        <property type="entry name" value="BIFUNCTIONAL TH2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43198:SF2">
        <property type="entry name" value="SI:CH1073-67J19.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003170">
        <property type="entry name" value="Pet18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="3">
        <location>
            <begin position="14"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR003170-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003170-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1946682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="216" mass="24921" checksum="0B99F73F13A31721" modified="2024-05-29" version="1">MRYTDQLREAAGDQWNRVIHHKFTKDLAAGTIDHDCLKKYLIQDHRFLDSGVVLFASMIAKAKTLEDRIPGCQFLALLTGKENTYFERSFEALKVSQEERSSIPNAACTTEFCDFVLSVAATGSLAEMLAVIVACEWSYLSWGELVLEEHVRKDFYCYEWVDLHSGDYFTSVVEYLRSLLDKEVETMNDAEKKACQTRFLETVQLEEDFFDFAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGD8</accession>
    <name>A0AAD2JGD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS11292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00075">
        <property type="entry name" value="HATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF66">
        <property type="entry name" value="HISKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="463"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="768"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="942"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1947755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="997" mass="109004" checksum="1260C55449D72643" modified="2024-05-29" version="1">MGLSDSYRDLGRREPPERSSMTGNTDLDGSLRTVGSVFSGSTSSTQSKLDQSSRVSQITWKGKLAFGLILAAVGLAFAFSAFFLFGEGEADLGELQYEAMAERASIIALQIMERKRLGLLTLSSVISGANPDARVWPQVQLTNFEVIANNLMKTADDYNMGFAPFVTPEQVESFEKHSYDFYETNRSPEPFPEGTAISPFGKGIYAVDPSTSERFHDTTGEVHWNSPNRILTPLLHHSGGPEKYLLSNLHADEALGSLIDGIIDCANSTSSLDDCTILSSISPNIIGWKPYDSDGAWGILLHPVYAQRSPETLSGLVLTSLRWSEIFNGAFANSVSGVYAVLEANDGSSYTYVIQEGQAVLLGEGDLHDTEYNDFRQETNLESKDRGNLNFFGEASVSYTLVLYPSEEFFDSFSTANPMLSSIGVVMILVVTSALFVMYDVLIRREYLVKKDLVEAKRKFIRFVSHEVRTPLNSVHMGLTVLRGELEAKYETDDAGPSGTMASRRASKKFVKTKTFKQLVSMADEIAMNCNGAVDILNDFINFDKLETDKLTLDLSILRLFDQIESISKEFKMVAKNNKIKMTIVTPLHPNQSGKAPKECFTVGDSMQLTHVFRNLLANALETTPDDGKVEVVASWHPNSMKNAKQNTKNFVLKDGKKMKVKHNGFMNFVVADTGKGMTQAQIRRLLHKGLDFNVNRLQAGNASGLGLWVAKGIVMRHGGTLTAHSHGVGKGSVFTVSLPTYDIDDPKPKGTAAQESVEAKDILGILKVLVVDDAKMNLKLLMRLVSKKGHKVDGAEDGAIAVDKASKAMDEGADFDVILMDYQMPNMDGPTATRILRSKGCNAFICGVTGNVMAEDIKHFKKCGANAVLHKPAKMKALEDLWIEYGVRGEFPLAEGAHDGEIEQEPKREIVKRNASDLSLSISSLGKHSPSTRVNMAGNVLDGSAKTPDYPSGRKTLGTGTGETSFDTDSDDLWASRMSLKSGISSMKSNISSVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGZ5</accession>
    <name>A0AAD2JGZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="264" mass="29678" checksum="F4350102703F9E0F" modified="2024-05-29" version="1">MYSTLGPTKASSPLEANIMDRGSEILKSHLNRCDQMEIIQTRRGWCQDDLGCAPRTEFNYFVGKDHVATSLEDSDPCYRIFCNGIHPFIMEVKELHSGLNILTVERPFACHASNCKCCCYQEASFFSDDDFLGRIEEQFYCCIPQFVVYDNVNRPMYKIHPPTCCSGIFIDCCAEGNPFGRGCCRQSFRVYPFSQENTDDDAPFVGKILKKPISVLVEMFTNSEIYVLDFPSDSSAAQKGTLIGSTIFLNSIFFQGEHSNGIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH08</accession>
    <name>A0AAD2JH08_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="193" mass="22426" checksum="45C35E2631BC9DA4" modified="2024-05-29" version="1">MSSNSSTSKCSSSSRCRGDHASIMEAQRPSPPSSLNRMHSASPRRRNGNNFHPLSTPNSFENDFPRLLFLDENCEDEEIDTFKIQRKLLRRRYVRREQNKKKRQREMENARQMALETEKHQIQPILSTKEPTAVQYTDSEDSMEQAEQKQRLLLSPSFRMSCGMTSPCYSPAFNLPCFSPLRPTKRQNTRVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHA7</accession>
    <name>A0AAD2JHA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS12665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHA7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1950604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40256" checksum="33FECD082AAFDEB1" modified="2024-05-29" version="1">MVSPARVASDELEKDHGPEKKGGFQCFSSIRLMVLAVLCLQNSLYTVLRRYSQGVLKENYSKHELLLLAEVIKIVFSAWMISGTLTAGTTLKQRIVYLVETSKKMFVLALIYGAMNILSFVALRNISAGMFTIFAQCKIMTTAVFSSIILKRSYSWTKWRALIALMMGVLLFSEPIWGDPVHRKEIEGGNVMIGTAAVITEVTLSGFASIYFEKVIKLDPLKLNIWERNFQLALGSLPVYLFFIAGDGGGMTGFFGGWSWIAFLLSLLGAAGGLLVALSIKYGDSILKTLATTGAIILSSLLDHYLLGGPLTPPMIIAAVQVITAICNYTFDATPPPPDTAASESQPASTLSDGKDDEEMNPQRKEIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ94</accession>
    <name>A0AAD2JJ94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28561" checksum="3B7807CCDE283B72" modified="2024-05-29" version="1">MSPDNFNWDRTKKSNTTRTIHAYSNAPFIELFVKIASQGIKPVGTMVLGEGSYAAEFEDVEWKAYCSLAAVARMEEDDDVAVSTEVTTCGPPFALRLSIHRPLSHTGTESALFLNGQDAALIRAADATGQMVLHMANRKNVSFPIVSGPGEIQGSVRQSKIIQSQQCSVAHCKSRIGPSSSPRPIPPKCLVGSTIRHIQFFQIPSNRIGHRYSTLSFRPKEVLYNSKKCPDKGLFQLPGIESTLIIRHNAKVHKEREAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJB8</accession>
    <name>A0AAD2JJB8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJB8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="286" mass="30343" checksum="1BF4C809FE081B65" modified="2024-05-29" version="1">MMSPLDSLSPVNGGLQDFPSLHFPPRDYWAEDKGGPYSNLLEDQHHGLRRSLEEAGMMTASYNVYWGATANGGCFGAFGDVTLTCSGNGVLDVMVPDDGNTDCESTSSPSQVICESPWPSSDAQVRIFSCSGKAKSDLLATASLSTAGASCSGVGYHLSALALAPYCEETVGGKVFRMTAYETCDSASTLAMLNDEDPGCANVFSCERNFCSFNLPKVTATVESIDIADHSCLLGLDEIFQPKKNDDEEETDTINNSTQPKTDSSGGNRVAFWIAMVVSATTAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLT6</accession>
    <name>A0AAD2JLT6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002090">
        <property type="protein sequence ID" value="CAJ1961199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="264" mass="29669" checksum="C8066D832C372BC3" modified="2024-05-29" version="1">MGVTIDPTAAGDHEPSAERNNRTLKERVRVALAQLPYKVVPKVITECLGHRAAELLNVFPQKNSISSHFSDMIAELGQYVHAIGTDDFPAQGRCPTRHRPSNPAEELLADADNDVDDRPELTVRFQGDDDYESDDDLGDEGNEEEEPIVANLDHHQENVDRGTNDIGSLLTDLEDLQEPPEEEIVFEPEEPYIAKVTRSGQTCAQAIISELNLSQVPKRPREWPSSRSDSSANENKNRVATRRKHQERELKPLKNKCFHSNLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JME7</accession>
    <name>A0AAD2JME7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002127">
        <property type="protein sequence ID" value="CAJ1963061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JME7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="99" mass="11148" checksum="0E93A8071360D155" modified="2024-05-29" version="1">MGKSKNNKKAATAAKVVNSTALTHGRISFSQKSEVETTKIRSKKESDNLDPPTDKNNSDTNMEETDNPLKYNRIVQNIDSSQWNLQTLAYLRTIHRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMZ5</accession>
    <name>A0AAD2JMZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMZ5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="508" mass="54614" checksum="55B082D80FAB98F5" modified="2024-05-29" version="1">MAGMDIVNDGKGDFIVPTKTGDDGIGSSSRSGGSISMNSFDEDEEVLLSTSQRSGGIFRSSNHSISRSKRSNRSTSITNQTGNKMRDSFHSMKVMLTPKKKRPAKTHVIVLDDDASMNSSLNSSDDDADDDEDDEEGDNDKDEFANDDDGMMMMMMSDHGPQPFSNIFGRRGSLDPASLAQPPQQPDFGCMQFEAALEMSIRSNDYYNESFSNQSGLTTETNSQTTNTTANTLSQTPSILLEAALGQIEGTSIIQSKSEESKSISMHSEPNHRWSADGQDEDGIKSVQTSRRRPRPGAKKKKSSRNINGSTHTSSSSRKSKPKKSLSAAAASSSSSAAAGAAATKSSKSTNGKPKKSVSNASVSTKKSKSSLSFKAPKKSNSAPLQKVDGDDHDNREKAAPAPAPVVKMKKAKSKKKLIVEVGDGDNASTKTKKKKKKKKLEGTSTTNDDDNDDDDATSKASTKKKKRATSKMDKKDKKSKSKRSLVKQGDKEEETTEPTVKEEGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN99</accession>
    <name>A0AAD2JN99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS20679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002191">
        <property type="protein sequence ID" value="CAJ1964538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN99"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042044525" description="Bestrophin homolog" evidence="9">
        <location>
            <begin position="21"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1964538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55616" checksum="78A960F40C442F30" modified="2024-05-29" version="1">MKFLSLNSILAVMLIGSTEAFAPANKNTAVLSSTASGSSTNPATTRLNLESLQPLEQITPDYDETAKLLDSYGEEARKYRRNVFGSADWIKSRRSTRFFDTILSTPQSALIRQISTEVLFISTVALFVVLYNDFLVEGFTDFDGVKHEAFTHALPAFKLPMVPFTLSSGALGLLLTFRTNVSYSRWNEARTAWGKVINDSRSIARMGCIWSKSYKGIDDASLQRLGDAICSFSRSLMNRTLPPQEDEYNFTKYTYERITDQKYAEILRNAKHRPTAALAELTSALVDFKLNPLHQVEVEKVVTGLCDALGASERIFTSPVPTFYTRHTARFLAFWLLALPFGLYEPLGGSWNHITVLPVVAVISGFLLGIEELATQMEEPFSILPMEKMCEGSIRVSVMEQVDRSQKGIQAPYYGEGKMLNVANPYAGEALDAAVVRQPALSMSQSMEEPAQVVHVDGAPNGLGAGGMVEHRHPEAFADEDPTKSNHSSPLLRKIVSRFRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNR6</accession>
    <name>A0AAD2JNR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002336">
        <property type="protein sequence ID" value="CAJ1967588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="347"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="438" mass="49916" checksum="85337E282D1A5E2D" modified="2024-05-29" version="1">MDCFHTTSNSSGTSTPPFFSTKLKNEALNEKEMAADTMPSPMNQLSRQERELVMFEIHGVNQVTTGSMEFQQEKLRSLSTELSLIVRGKSAFTMAQSQNLQYTINPDFRLLFLRSTDWNVTESAQLMLQFFRAKLELFGPGFLTSRITFNDLSTQVQKSVRLGFIQVLPFRDTAGRAIVVFFPSLLENSGTSTEDMVRAAWYTIMSASADIETNMNGLVVIHYLAKLDWSQLDRIGIWQIAKFQQCLPFKFRAAHICDANTDGGSFYHAIFIKTLDAISRVRLLHHSGSNLEVVYKLQTFGIQARILPLDKHGMPTKETHQKWLGRQQRLETEERNIHRVLIPTNKDVLKGRGRGVQNHVGNLRFRHMVAERQNEYDANDMFGAKGIVANKVMAEIESEGGRFLKDDGISWVRLDDTDAREKISMTFRSQRKDSNASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNV6</accession>
    <name>A0AAD2JNV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein xylosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005049">
        <property type="entry name" value="STL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362:SF0">
        <property type="entry name" value="EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362">
        <property type="entry name" value="GLYCOSYLTRANSFERASE STELLO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03385">
        <property type="entry name" value="STELLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042174024" description="Protein xylosyltransferase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="95647" checksum="0976FE2EDC7CC711" modified="2024-05-29" version="1">MKRNQTAAALLIVVGLLIIRNANFSAEISNLLRSGNDADRNNFGVRSEPPTNDDTLNKNSLNNAHTEQTIQLPSAQSVIPDQSSGKGFKGEKIRDFSSPRAELRKASDSNESLPWENDFKAKCIKWGVVTTIFDPTEAISRVSNLPEWCLVVVADTKTPTNYMEAFETMGGATEVTFFFSSELQNTWEHLDGPIGDFVRTMPLGHVGRKNLGYLFAILHGADFLFDFDDAKFIKVDEVTGKPVEILPSIETIDNVAIAISGPLAFNPYPMMNMSVPAPSWARGFPLQYINDTATQGRAFFQQSMPFVSKSHSIGVIQFLVDGNPDVDTNHRMMHPLPMTFDNSENATNVLVPKHAYCPYNAQATIHTQPALWATLLPTTVPHRVSDIWRSYFAQCIFADSNLRLVFAPPKIEQQIPTERDILADSSAENDLNIKSGKLIHFLSTWDSEHLHFPERVEQLWIDLYERSYIELDDVVAMQKWLKALVAMDYQFPDLKPRFRNVAMMGQFNDAHSHIATTQIMIWSQKQRERFQIAIAAAPVEKAQLAYLEAQHIEVLQSYQLKPIGIGALCCKKLSFECCDDMGYYNPMSNLMRTLLRFGNSSTIEAVLYAHDDALLNLTELSEGRYPFPTDKIIANRQLSEVDNVEYVDLRTIPDRAKAQRFSHRVFPNGTVSDVDKTIFVNNSSELSKKIPKLHDKWERWGHTYCAPAQQQMAMDPEFAKYLDPDGSAWFPFHTQSDFLMVPTKYAEPFAEAVNIHLKYLVWLECAIGKIVDILQQQLQAPTRLVYLCTKFKSKYRGWFSPIYDCNKSNDTIAVFHPLKWRKRFDVFWENSDLINFPLEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PTX1</accession>
    <name>A0AAD2PTX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001714">
        <property type="protein sequence ID" value="CAJ1946550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PTX1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="483" mass="54977" checksum="928FE848B17F8EE0" modified="2024-05-29" version="1">MPVRTVEEKQLNVHNFFLIKHIVDDREAKDELNLIGTMVQHVFRGKDAMEEDVFTSKNYHDAVGRIAEDTQSHSFGFGLAAGGSNHSTDLNSLDTLDHADAKEETPIMFKYRFNDAKADKQNLDLRRTEIHETRDLGKDYRHTLQVKAPLELDVVFDAFPFKVKTATLMIELSTFTSSDCKTRLRPNIIVHRKEKRIMFGIQKDPNASSSKKSKKIHPAVAVYQSLSGRETALFEQAKEKIDKSYVYDFVSPFPNITYLFDNSAKKYCPKYSIQFLLVEDGMKKFFEIVFPMLLIAAMNHLNVVNAVKAIRNGNEMEVEAVDYLNNSATLALSVVVFLPTMIGTSRFHSIFQVNNLYISTIFVALALSSLPYAVVETTIPAQVGTYLFWASFLFPVVNGFRFWRFVRAHEAPCSHHFMDDARGRTYPQQKFKPSPDSDVMSDFISIEELVNKNPATIASMDFRLAEDRGKFKVLEIDTASLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU53</accession>
    <name>A0AAD2PU53_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS10990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="501"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1947125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1622" mass="182152" checksum="5A8893DF1DA28D09" modified="2024-05-29" version="1">MHGLVFEIFEDWVIELHGLEAWHSIKKKADCDIKDKSFVTRTFYNYDIWIELVTATSEELSMSFDDVLESYGKYSIRYHFSHGHEALLRCQGSTLRQWLSNLNAMHDHVQRSFPGENFCAPVFWCEDCDTVEGSILLHYFSLRGCLLVPWVVGIVEELASFHFEVDVKMNLLAKQDGYASKFTTWRITAADETQMWKLSPKAAVLNDGDDDEVVDFSEVKLPSKCPFSGKNLQKDADGIDNMCPHGKKELERTTTETTATTATTASMSTAVSTLTEVKETTVRPGLSLEKMQAVFPFHVIVDKEFKIVQVGEKLPVLLKATNSHDLVGVHIKDVLKITKPVLGTSWNWSSLNKLSDQNFFLAPAIDDASTGNRATHITADGQQRFGMGGGAVKFKASIVDLDGDLAMFTLSPEARNVEDLNHMGLDFSDLPLHSCQRDAVFLGEYIRQEADKAHGLDKLSRTLGSEQALSNTLLYNILPKQVADDLRKGKTIEPKFHENVTLFFSDIVGFTDLCGQVEPWDIIDMMNQLYSVMDFLAAKFKLYKVETVGDAYMCCSGLPEPDQYHAENVANFALAVLECVKHIKSPVTGEPINLRIGIHTGSCTSGVVGTLTPHYCLFGDMVNFTSRHESTGAAGKIHASSFLYGRLTHFSQSDNQEFRFKARGLVDMKGKGEHYTYWLESGTEHNEYANPTALEDLSEEVEAMISSEKWKMRKYFKNGGILRVKQPVASDNTATKAESRRSSGISAKGAGALQRDSEIMEAIKEDDIQTYSEMDFEEDAIDSFGKSWENLQWGECSKNALQGKIFDILLKVLQQCIGKGGARLNVINGQLEKYVKTIADLYSEANAFHSFKLAAEVVLRANFIWDTWATDVSKDPWDHFMLLFAALIHGVQHTGIDNSRLEAENDVIVAIYRKKRAYQQRSSFDCAFERLDEDFEELCEEIIFGCPNFRASVKKLVVNFTDLENEEMLRAMVENFEKILAKTSKTQRALKEQREAKVGLVLAMSTIGHYAQSYDNFLKWNHLNFQEHLKAHRSGRSEDPRDSWYYEQNMFFSDALVPLVNQIGRALPKATCLGDCVLRNIEQWRSNGRDRLAASLVSTATVEDDRGEKISLDRMGALVAANVELLEDLLKDIVTYPADNGYEDNAIADFTPTPDLPSHVRTELRHFVIMIASGYESNDFHNFQHASHVAHLANLLLNGINGVDGSKDGSGIASDPLARFAIVLSALVHDIGHTGVPNGQVAIENPRLAEKYSNKSIAEQNSIDIAWNILNSESFEHLQNYIFEDAGERERLHKLLANCVMATDIFDKDLRSIRKAQWDKAYSHKKSFDSDEEEENLKTTIVIDHIMQAADIAHTMQDWELYREWNEHLFLEMYQAFLDGRSQTDPSSGWYGGELWFFDNWVVPLATNLKACGVLDIVSEQLVKQAKSNRDRWETHGKEICEAMFISATAKVNSRSAHHARSTTPMHPTESEILMTSKMVTEVEGLAKVVKRYERKMQSACGNLIAVAYKGRPGGKELRKKSWGDIHNHFKQQEWYKMYNADDDEPSSADGSLPAPTVNIGKLGSLHLRGRRIGRVSIVSNHDDDFSMGDDVSSIGGSFASGLPNQLLNAEKIITSSADGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVS2</accession>
    <name>A0AAD2PVS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS16533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVS2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="9">
        <location>
            <begin position="650"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1957074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1035" mass="116414" checksum="87E1ECE29F1D83AE" modified="2024-05-29" version="1">MPYPLLLASQRRLLAAGNKSGSLKTAVARSFSTKPQEIESFLSGTSSLYAEQMLEQYEEDPNSVHPSWKKYFDNLQEGVAFNQEDYARPTVIPGKRQGAADAVPSDSLAVSHIIRSYQVNGHLAAKLDPLGLYTADAFPFRPQATTPDGYPEELGHEFHGFVDADLDRKLHFVGGASGGNKGYLEELSNAPHKVTLRAILDELRKTYCGTLAVEYMHIGDKNKANWLRERIENPRWLNYDKEKKTHIFERLCFADTFENFLAHKFNTTKRFGLDGGEAIIPALKDAIDRASELGAHSFVIGMPHRGRLNVLANVMRKPMPLIFSEFQGTNYNVDDYTKGNSKWGISGDVKYHLGSSMDRTYPDGRTIHLSLVANPSHLECVDPVVAGKARAKQYYSGNRPEDMRAVVPVLLHGDAAFAGQGVVYETMQLAKVPDFDVGGTIHVIVNNQIGFTTNPIHSRSTPYCSDLGKAFNCPIFHCNGDDPLAVSTALETAVEWRQEWGGDVIIDMVCYRRNGHNELDQPSFTQPRLYAEISKHPSSLQIFEKRLIEEGTLTQEEIDEIKQFTLDSYESDLEASKTYETKMDDWLSSKWTGFHGPKQISRIRQTGVDIDLLKKVGLQAGTVPDDFALHRQMAKIFKGRRDMAEAGTGIDWGLAEAMAFGSLLVEGNHVRITGQDVQRGTFSHRHAVVKDQKTEEEYAPLNHITKKMDPSCPKEEMSGPDTQAGFTARNSILSEFAVLGFELGYSLENPNALVLWEAQFGDFVNGAQIIIDQFISSGEDKWLRQSGLVMLLPHGYDGQGAEHSSCRFERFLQGIDEDPHFVPDFSRDERMQIQKHNWQVVNCTTPANYFHVLRRQIHRDFRKPLIVVSPKNLLRLKKCVSTLEEMGPGTEFIRVYDDTDPMVNEDPEKVERLVFCTGQIYYELLAERETRGLTNTALVRLEQIAPFPFDRIAQSSAKYPNAEVIWAQQEPKNMGAYSYVNPRIMTATREINHDERRPRYVGRQVSAAPATGMSRVHQAEFKDIMEGVFGVPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW49</accession>
    <name>A0AAD2PW49_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS17735</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW49"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="325"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="480"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="530"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="736"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="188"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="736"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1959313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="842" mass="98712" checksum="AF05B1BE38915437" modified="2024-05-29" version="1">MQYPQAIEYPPRIQHDEIDEDGVTLEMKETWVLLCRLLYRMKYQEDIPTEATGQSWHALIARAQLAQDMWKSLSHEVASRDFAVYQKMSNKVDSLCRRAHRLAEERRAHAPPDLIDEIFFSNDSNDSDSDSDDSKEGMQEEQHTVKSAYASDESKDEENESNDRRNKMATPTRNDAKNTTPMTNEALQKAQREQMEEAIAQMARHMKEATMGISNTLQQQNQSTLNELETVAEQNAQDMSKVTTDVTDHNRRQWRKNFSTWSMMFLLVGIFVFTMLMIFTLPKHPTGSLLGKRGMIRTSVSWASTKSLRVVQWATDKSGIMNVLEGDELPSSGERVPEDLFEESEAERRQKEKLDQIIASRKARDFHDNFGDDYPDHEAEQGGKPKQKSTKTNKNTNAGSDGYMESKITASGDIENDVKQDEGPADVDMDELIASLNRQAQKALEEQKAAQKKAEEAARKAKEEEEARVRAEEAALLARKERERKERQEAVRIAREEVARKEREEEEARIRAAQEEVKLRAQQEEELRFAREEEEAKLRAKEEAERKARQEREEELRRAREAEEVAEAERLAQMEREEALQKAREEEARKAREAEDARIRAEEERRVQLQREEELRRAWEEEEARAQREAEEAANAQAERFAQMEKERIAREEALRKSKEEEVRKRTEEAANAQADRFAQIEREQMKREEAFQKAREAREQEEARVRAEEAAAAEAERFLQEKQRIEREEALKIARQEAERRAREEERERLEREAAWRQARGEASRQEERAQQNPHKSDEHLEDRLQQIHENTDHNRVEQEKRARMEDAKRHDEDIDMEEYVERGREKLDEYLGREERHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWN2</accession>
    <name>A0AAD2PWN2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWN2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="308" mass="35205" checksum="70160F75646C36C3" modified="2024-05-29" version="1">MGIIDKRRTRRRDLLLRNSSSSSSMLVTKTDGKTILNDRPQEPDHHNSTFDQDHSHHPTKVESMRTLLMNKSEDGGIIGSEIFCIEKIGEKVPPVSKAPTSQVTFSSVYTSIYIPRRTEAEKVSSFYSQEDYDRIKSDTVDTITEMETEKKYPSSETQYHRGLLTPRAKYEKEQRIKFVVSKVLREQERNKCLSEDWVNTFSKKYSSQTTTAAFFLGKIDAKAAGAPDTLSSHSYIRCLQRPNAPRRAAYHSTRNIDAKVTDTLWSHPRTLRKQSSTQSLRTQSSTHSQQTPKASRRATYHGVPLVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXD5</accession>
    <name>A0AAD2PXD5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS21608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="285" mass="31677" checksum="61FA1C631533E3DB" modified="2024-05-29" version="1">MASTQSSDEQEPSTPAVAPAPMEIQPPPPAEEAPSEGNTFSMGGVVGGNIHEAGSFAKERAAELRLSVAEGNWSLRIFVLLAALAMITTSLIGLISDVYRIDTISAIIDIYCMILGVIMIILEYGHQLSFFAAIQPSLYRNALFLRFVWGRGLFYFVAGTIEISQRHYMNIIVGSLVCLLGFAFAIIGRSASQKLAEARRSTFTMEDLRSKFNESDEEMKGSLDMNQFSSFIKLLGMDMNRREVETTFLQLEEDGRIAFEVIVEWWNTEATENFSVIPGDYQHMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY33</accession>
    <name>A0AAD2PY33_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY33"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="279" mass="30928" checksum="486E10CA3BE3AA0B" modified="2024-05-29" version="1">MEVEVPFDEVCQPEAASAASASSSAVPVAIQEEGYAAEENNNNQEEDDEIPDLRQESILTSGSSLDGSEAIFRPHKDAKSSSLMTQEQQDHHDHHEEEEDNLPDSPTASIVSSSSSFEEEDDEDDDSVDDEDDNSVASSTGKVDLKDFDDRYDRESVAFALVDKMCAPVDMVCSPKHQLDAVHDDDNDGIIRRRERNEEDDSYTFFPRKKQEPKFPLGYAACASEEAPKSIMSEAFDSWNSLLQKMGSQLTVQEFMEQPAPSFQSAASTGSQKERQVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCL1</accession>
    <name>A0AAD2CCL1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000041">
        <property type="protein sequence ID" value="CAJ1928385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCL1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1928385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="505" mass="56882" checksum="0CC87DC3E0D68FB2" modified="2024-05-29" version="1">MAATRIAWRNYIRDVLDFSQDEAQEIVIEQGFSSPAFFARSTRENIDSLVKQINRTVIDPGNDPDTTFSINQAQKIMLYDLCDYCRFIYMVDRQHDPAFGTQANLAKINRYYSHLKNKSNKFEDISEVMPPKFDNKNTVELMESLEQWLKRNRGKGGTLLTYVIREYQNPDDNPTADPGFLMPSVEDEAIRRSLHQEDQFVANNKAVWNMLYSVCHGTDAWPVIKGYKTTENGRQAYLDLVAHYQGEGQLNKRRDSAYRILNTTHYNGKKNFSFEKFAARVLGAFEDLKNCGDGMSEHAKVTKFLSMIKEGPQGAGLDACKTLVRGSQACMQNLRTAINTLQTEDTAQQTHRLTAISGTRALAAVDGGGRNSNRGRGRGRDHDNGGRDRGGRNRNRNQHGRGGGRGRGGSQDHDGTVWSDDGTTILNNGGYSQDTWSRFSDRDRRVVLQARERANSRLMSERDIAELNTLREQNRDRQQSDEPAPTPAPAPSSGNVGSGVRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CD04</accession>
    <name>A0AAD2CD04_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1920931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CD04"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1920931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="638" mass="68692" checksum="E992F43CD8FC1D84" modified="2024-05-29" version="1">MEYSPIDRSPTSAPTPQPTPFRLTPVTPRPTQGDRAPNPYPTRATAAPTPSPSPPPTQTSPAPTPPPTAWVNPIVTPRPSAKLPQTSPPTTPPTASQVVMSNDHCIHALNIVSLPFSMADTTAGSTPDFAVKTCGVVSEASGVWYTYTPTETRSIRVFVDKTSGSARSYLRVFYGDDCDALICRMYSGGFSSRDSSATFVGQAGVTYKFLVSPGSGGSSFLSEYNITVQDYDLEHDKFDDARNIASLPYQRADTTVGAVPDFDIETCGVDKSAGGVWYTCTPSETRTIRVYVERTSGTSINTRSHLRVFSGNEFGTLRCLRHDGGYNSGDSAATFVGQAGVTYKFLVSTASYTLGISSYTITVKDYDLENDGFDDARNITSLPYQRADTTVGAVPDFGIDTCGVDSSAGGVWYTYTPSETRSIRVYVERTSGTSVNTKSHLRVFSGNEFGTLRCLRHDGGVKSGDSAATFVGQAGVTYKFLVSTAFYTLGIPSYTITVRDYDLENDACDDARNIASLPYQRVDTTIGALPDFDNDSCGVDESAGGVWYTYTPTETRKIRVFVERTSGTLYSNRSYLRVFSGNECGTTLTCLTHDGGYYSGDSAATFVAQSGVTYKFLVSTGVYGLGIPSYTISVGEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDE4</accession>
    <name>A0AAD2CDE4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000076">
        <property type="protein sequence ID" value="CAJ1929292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDE4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="100" mass="11555" checksum="EDB213666F83B01C" modified="2024-05-29" version="1">MKADYEEHGAILIARCMMQIKAKFDTDEGLNFIQQYYINQGLKKFGDDGKDAVDKELRQMLLRDCFTPEIVKDMNVSERKEAQSAMMLLAEKQFGKTINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDF3</accession>
    <name>A0AAD2CDF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS2106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF81">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE CEPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1930825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="844" mass="89778" checksum="701C03196D4827C5" modified="2024-05-29" version="1">MKLYQEAIEAEERFAGSDSDSDESEETSEEEESSEEESGSEEESGSEEEESEEESGSEEESGSEEESGSEEESGSEEESGSEEEESEDEESGSAEEEESGSEEESGSEEEESEEASEETSDDEETTEDGSDEEESEEESGSEEETTEDGSGEEESEETSEDEETTEDGSEGEEESEEDDEEDEEADGSGTDKSGSKKSKGASDSEKDEESSSSGVGLAAGAAAAGVIAGGAAGAAVAAGSKSSSDESEKKAKVFEEGSSSSHPDSNSTFDVQGALGDKDKDKASAKEDEPEFTDFYKNTDGDADRDVEMGQDPEPAKKKEKKEKKEKKIKEKKAPREKLDPNSPEARKKRRQLGFFLIACLLLLLGIGVGIGVGVGVFGDDDEPTPATASAPGASPAPSAAPSMSSAPSTLQPTDDLSSLIIRASLPTTETGVWDDDDSIQVKALQWLHGNENLQFYSDEKKIIRWVLAVFYYSTNGDNWTTNTNWLSQDLDECTWFTAGNSPACNRDKQFANLELRANAVTGTLPPELGLLSNVLEAINIRGVTGSQVAGSIPTELGFLTTLLDFTMEGNAMTGSLPSTLGGMKALQTLNLADNNFNSTVSRTVVRGLTDLRSINLSNNDFQGAVTSDYGRLTNLRDIVLSGNKFTGAVPAQLSSLTSLETLNVASNSFVSQLPRQLSSLTNLKEFTIRDNAFSGTIHTELGLLSNLEKLDMANNKLSFAIPTEFGLLTNLRVELDVSNNNLIGGIPTQLGNLSNLRRLRVNGNNIAGTVPSQLSNLDAIRVFRIDDNDINGAIPNGLCSRISVLGSAAFADCREVSCPCCTHCCTGGSCTCQSSNAVVCAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHC8</accession>
    <name>A0AAD2CHC8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000379">
        <property type="protein sequence ID" value="CAJ1934751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHC8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="320" mass="36466" checksum="667CF938D107B344" modified="2024-05-29" version="1" fragment="single">MVICGIDNVTLFQGRTQAERIAYKIFSDDFTTTMDSTIDELNQQFKTLAGLTIAQGQIRLMPAIKNNIRTFIQWCRDKICMGRDPSTTPFPVVDAAKLLRRMKTHKQYVYGSKLMLQQALLQDFTNDVHWEDWCPTFKNYLRTIPGRDGVPLSYIVRMNDAGMLTLHKDFLETYVNMAPHVGKAYVMDNAKVLVLLSNFIVGNTKAEAILQAINIAGNGREAFNALRTHYEGEGIQPKMNWSMFEQMLKKAYATCDKHQGREVHSDAMKLRSLQNKVTAPFLQLNKMAIDTEVDDFHDSITNLPNCSERKVSPGNQQCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHK1</accession>
    <name>A0AAD2CHK1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000375">
        <property type="protein sequence ID" value="CAJ1934748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHK1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="478" mass="54226" checksum="24C3716C04BC0408" modified="2024-05-29" version="1">MDLFINLEVEQEELLWLNWCRMFLQVCTVSDIVTADGRFIRRSAWNGFRDECCRSPYQWPRTVRPTRQHWDLWQTTLSRALLASNGPHHPLQQPLGPWTDRLEDWNRLLSPTTGLFHRHGTTWKHFCSEGSHTTSRRYAPGPSHPSCPWWTAPLPSDVLRATVRSITGSDRVLLTGTGRASEPSSSSSPSILHAWQTAAELCTDYYGWVPNEIEVHGDEATLADALLDGRLRVISDGSFKNELGTAAVQILVKHGGCHRIIIRCQTPGLPQDQSPYRSEIIGLLAGIMAVDWLLEQWFPTLLTGPKVRIACDGLSAIEMAFEDRPLSPTDAQFDLVSSVREAILRSSVDWAPQHVYGHLDKSNLYDELSWWEKRNLEVDGMAVEYRKELETANHRIAPNPRFFTELAAMYVADTKQSRLDPRFIQECVTLPALRSRWSDKGTISIEAESEIAWDTMGRAMRSLPAGLQRWSTKHCVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHW6</accession>
    <name>A0AAD2CHW6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000402">
        <property type="protein sequence ID" value="CAJ1934870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHW6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="416" mass="46719" checksum="186BDA106BEFC885" modified="2024-05-29" version="1">MPSSEEDGGKKRQVHPIEDETPKKVKVDDVPKQSPSSSKEPPAPSTTTTTTTTTTTTTTTKPTPPSRSTPSNVASKPSPESADEQDVPSPSFNLEKIRSMWKDKDRPVWDLEGALLYLVQELDEREYLTHDETVWVTFRVGHAGDASTIANWYRLAKKLVLEQEAAEENNNDSDLNKEEEEEDPEIETDQVPQQIPTEPARAEEEEGNASNSAGMLEVWLADGFGDDRRLPYVYGLVADVHMISASSKQVTGPYLSPSSDQEEDEDHDDEEEEEEDQKKEATVDEIIDIPPGDLKKSAVTKELGAVALLTTGFDEGLEKILKIEWLGLNPDLPTAALIILRQRVWLRLSTLAVMMGCDGGIEWEQRFSLDPLQHQHQQHQEQQQEQQQEKEQQEQQEGEEEEFSKKPPARVSPRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ72</accession>
    <name>A0AAD2CJ72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000125">
        <property type="protein sequence ID" value="CAJ1931113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ72"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="82"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1931113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="580" mass="62791" checksum="6DCA3699742C47AB" modified="2024-05-29" version="1">MRTQESTDDWTVPSTAEPSTIAEDTESFANIPASPVDVLKLSFAPKHESIGVKSSTTYTSACVSIEACDMPEDEAERTCSVDICVALDVSGSMSGSKLKDCKSTLEAMLRPLSTKDRFGLITFGSRCDVVFPALLMTKENKAAALKKIKALSTNGCTNLSGGLSLAWQELLLVDNPNAVRSLFLLTDGHANEGITTTPELVEMVKSFNADSASDISAALNESQAAGRSNPSSSLLYSVTPQMNTNVAQTMNIAPTFTPPQKKGIMRIFSKQSSKGSMKRVKRSSGSSSPSNVPRTINLTSKGAPVSLFCFGYGSDHNSEMLEALSEATPGGGYYFVENDSDVFTAFGDAMGGIMSVMAQSAVLKISVPSAASECGVKIREVHHDKKVDRGDGSFTVNMGDFYAEERRDVIVDFDLANVTSNEPVLHLVATVSYMNVLTKKNTQGGPRDCSISRPDSADLSAVNQDVEAQWLRVCVVREMEEADKEARSNNREQAQARMRRVAATIQASPAYNLEDSFYCSLQQNVDESMVDYEASSYKGHRSKNIAQTLKKQRACSSKSSSNGYYQTKSKKKMSKAFEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ75</accession>
    <name>A0AAD2CJ75_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000456">
        <property type="protein sequence ID" value="CAJ1935348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="243" mass="28623" checksum="14B3C816A207F9B9" modified="2024-05-29" version="1">MEGLEYPQIMISAIKELNEPDWDDLKPKLNLTGQEDEIEKEAKEEELKTESVKYHRQKRYWSKAKWHVHSLIMESFVTSKMKDKILQEVDYNEKIDGDPIELLRRINKFMTTSDVTDWEPITLWEALQKWVNCRQNGNETVIEYRKRFEECATTVLSFMGDLWLDVFASKTTPYHEIKNNHPTNGLSDRQKKRVAAEVKALQEEFVKLFCAAGLLHNCDRAKYQPVLDHFVTAYAMEHVDYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJE8</accession>
    <name>A0AAD2CJE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS4152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040000391">
        <property type="protein sequence ID" value="CAJ1934815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Prp19 coiled-coil region" evidence="4">
        <location>
            <begin position="76"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="323"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="395"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1934815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="513" mass="55421" checksum="A9E2C971E85880C4" modified="2024-05-29" version="1">MSLICEISGESLASTTEEIVVTPSGHTCIKRLLLAKLSENGGVDPFEQVQERPLSEDQLVTLSKKASIPPPRVHPTSLPNLLQQMQKEYDALVLELFDTRKALEDTRQELSQALYQNDAAVRVVARLSMERDAARQELEKWNSIVTTGPAAAAAEQTESAEEPSKKRRRTETPSEPLQNDIPSDDLQEMVDTWGTLQPQRKPMLKKAAAAAPTAEDLVGYVAGDKKALHKTTCKGLTAMAKAGNVLVTAGKDKQVIAYSLSENVVLQSFNFGSIPTCVDIFQSSLVAAANKNGRMIVYSLPDGSIVGELQSKTPIVNLCIHPSANHLCIATKAGKIIIYALQDQKIFPVSEFSGDEAAEYTCGALHPDGLIYAAGTTTGKIHMWDFKNKLLASVLEEGEDSVEAIEFSNNGYHVATSHSSATVRVWDLRKQKTIATLNPDKSLLEAVSTLAFDESGKYLAYGGKGGVQITAVKEWGETAKLASKSPVSAIAWGEAMIATTAEGDRVVSIHQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKB7</accession>
    <name>A0AAD2CKB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="439"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="528" mass="60997" checksum="BF91478DE83678FE" modified="2024-05-29" version="1">MASSLSNNPFARRARLPCFNNDDGQAPKDKNTPNHFQMPGNSNINDAITIKPAMKETEELLASEMSQLSVQERSKAMDDLHCVGVELQETTEMIQKSLAEFEEAVQKERNPIYKMAINQNRAYEEDPTFRLRFLRAKLYNVREAVRTMISFLEYKAKYFGDDKVARDITLDDLSEEDKQLMLSGLFHIQDGRDRNGRLIVHFFGKLLSRCKADNLIRIGYYIMYSILSSIPDVQKKGIVAIYNDTTQPGEKFTMPEFNFIKESQGFFASVPTRYSGMHYCLQAKSRNLMVNNALVSLFLKGLPQHDRVRTRIHYGSIMELRYQLQSFGIPLSTIPFGVQGNIRNDILNVWLDRHLEETNQRIRFYQPDAAWGWSQDMEIESKRSKQPQHGHCDKNEDDAIEALGMEVHDSMWASSTEVGPDDAVPMNRTTGPIEPTEMDVLFGKGYRLQLHPGNVRFREFLEQRRGEYEGTPRQNRRDIAIKFAQMLRNNGVRFLQKAGSEEWVESDSAQAETKVAQFFRELRKKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL46</accession>
    <name>A0AAD2CL46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="269" mass="29768" checksum="2AA32CBC7130C19D" modified="2024-05-29" version="1">MNLSMELEDGNGDWDCYSDCDSDSEYSYETINTNDSGDFSSDGLSTIVEETEKDLMSKCSHDIDASFRSDLDSPIQMPRATISLGAFLERDERRYQSNNLDVTAHEINNLDLNSESESLKVEEVFFQKSVNSFFTQDDDAKSFNSSSPSFFQKSANSLNVQEIFQRSTSSFATQGSDAKSVDSSSTTGSFRLAQLKLKKSLSLRKLKTAYEAADFTSSFRKDDENASKCISSMEQTLLKSPASARSSKGQLAAKKNLLNAISVLTISQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLA8</accession>
    <name>A0AAD2CLA8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000723">
        <property type="protein sequence ID" value="CAJ1938453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="110" mass="12028" checksum="9C9EDC96D455B85B" modified="2024-05-29" version="1">MDFNWDRTKKSNTSRTIHAYSNAPFIELFVDIASQGILPLATMVRGEGSYAAEFEDVEWKAYCSLAAVARMEEDDDAEVSTEVTTCGPPLALKLSIHCPLPHTGTGSALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLD0</accession>
    <name>A0AAD2CLD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3 4">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1937834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="653" mass="73677" checksum="6ACE128C3A977372" modified="2024-05-29" version="1">MATKRTNKSNIRNLSSPDEAQPTTLHSSHPQEASVLDDDHSDHAYRVKKDHGEDITSSKSLTQNTYSIIYVADPRSWAFFYGIVFFLIQICLMSFALIGAFDVGSSNFFKVPVDVSIWVRISGYIILLLSVPLFGDLLDTIEKTHEGYNPVVKCQTPHATFAKWVFANSLQFAFGIVFQFVTFVFIAKSSSVRDMLLNFAGLEFITKIDDLGFSLADRGYFTESLKNASKDVKDHKRTTTKGPWFRIVATVFLVCALLAGYSVIFYYQRTGAFLCTRMEVQFGDAFWAELPFFSGVYFVDKATRMDQRLVFGDERTDGKESFFRYCQSEKSFVFLPQQNNADDECKSESWYAKSPKSESYNILKSNANEWKTQRPGENAIFYSIDHFTMNCLDCSPDTCNIPLGGSCTTDDFSNKVCVCNEGFFGNQCQFEYDQICDTIEFDHRFAPFPIQKYDFPSRLEVVTTSSDYYMLYRNKAVYSYVYPSDSESSGYMNIIAFFGRRYYFLIVDWAGLFATKTEAGSEHAALFADLTPETAPAAFVKYMNTFLADGFLGDGELVSPLFVSEPLDLGTPQEKPDPTELAWHLVTTDWYGTRLGIGASISTRLLCTRCDDATGPYCELAGSCNSETSTCDCLDGGFVGPRCEYYDPAFNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLV3</accession>
    <name>A0AAD2CLV3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS4719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the stanniocalcin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000466">
        <property type="protein sequence ID" value="CAJ1935384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004978">
        <property type="entry name" value="Stanniocalcin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245:SF6">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245">
        <property type="entry name" value="STANNIOCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="622"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="669"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1935384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="713" mass="79778" checksum="135732E933EEB3FE" modified="2024-05-29" version="1">MLELFRAESASYGTQVYDECQTPILDSCDHFYLECLEKSHSCGDDEGYALGFGLGLCQHYPAPELFSVGLRAWYRELRRCLKFSLVETLDKADGMTCNDLEQFLTVDHYRDCFNQYNDGNSICGGDNYKDLLDVLRDLEFYFEKNQAFWDAFVRYANSCGLTTNEWRFYDIPIINIPTTFEDWPENINEFIFIGKVEISFKLLQPYFDLTTEQSEDIVDTVLWLLRVSIDFSSFEKITRFGETSISEDKTWTFKLLVVAQDEDAAERVAADVRAYFSSNLNGNDGVIVVPDYDDDDVDDAFVALSEYVEFLYAEKVNKTSCQEPSGKTCKFYSECLEEKFQCGDSGYPLAFGLHYCEVFLRNDPDFSEEGLVWAAKVRQCLQDALVETLDRDMSCEEVETFAFDSHPECYASTGYCFIPVSDWWNLFWAVEPNVQISGAFWSQVGQTIMLCGPKWVHAAEFLVMLGKLYSEMVAEDMKQSYVDTVLLLESLVSKGTEYIFRVAPIMNNNRRLASSPGTSLQMSDTINATAIVNDFITNYIFTMDDIDAMVLPGEVISPVDGTNTLSFNLFVVGLDKTTTDMVFSKVADLFESTSTVTVDGFNLELISATKFDYDFLEGTSSLSPTMEPTDRIQASIGPSTSSPTALITTDGLEGTSSLSPTMEPTDRIPASTGPSTSSPTALSTTDGVEAASLTPTMDVSGRPPETLCQPTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMK7</accession>
    <name>A0AAD2CMK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMK7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051158">
        <property type="entry name" value="Metallophosphoesterase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="287"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1937878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="619" mass="68030" checksum="9DEE454CF78F56E6" modified="2024-05-29" version="1">MSHHADNDVNNSAETSSGNNQQSFWCSHRRKLLSAAGALLFIGLGIAVDLLSGDGAPLYTVMWFVGLPVVFLILRYLWLRLCRDPFLSQSDTLTAVTWESTTTCPPSLQRTVPTILFWTFIVLCFAGAVLGFDVRNENLEPDMFIVVTYSGFGSLLILLSAVWLVDALCLCYLFVIRDKILGHTGVAQDWWYRTNIVWASCQQQEAAAAPQSVATTATGNSETAEAADTVKSRQLDQIRSAAKWRLLLIILLYIWWTVWSYFAAYDPTVLILNVPVPKLPPQCDGYKLAMAADLHVGSMAGLSDAERMVNNLNALNPDAIALVGDIGDQPVTAIIRQKMAPLARLKAPDGVYMSFGNHENIKGVEGYRKLLRDEAPFAETVVLLENQHAILDKASTDGCSVALIGMADWSGQRDGALYEDQIAPDFEKAIRVQAGLNGTSIEKDEPISSDLPMIMLQHQPCGIKQAAKDGVGLQLSGHTHGGQIWPNHITLLSYDGIAGLAEFDVGSEHGPSYLFVSEGVVGWGPRLRFLSRTDIALLTLRTPEAMKAEGLKPDLSVSVATAAMYFATAIIPISLVLWSIPVCCWVRQRRTDRRQQQQVETESKDKDEEEGKTVSNRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNF3</accession>
    <name>A0AAD2CNF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS5536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000613">
        <property type="protein sequence ID" value="CAJ1937159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041944251" description="RRM domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="87"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="180"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="271"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1937159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="366" mass="40548" checksum="8544762B9DB51833" modified="2024-05-29" version="1">MTVRITLFFFLAVSVTSFTLRTPVLRPSRVSIPQRLSQESAENIAPVIESVPEELATFDVVESSGDALNEGTQSNEVIGDAAKAERHTIYIGNLPYSTTVRDVRALVEDIADVRYIKLPKDREVDRIKGFGFVDVASADDVLKIVDALNGFEMEGRQLRVSRSLEKDQIRSTKREVVGSKKLYIGNLSYKCTKEHLSEYIGEFGQLTDVFIPQDNYGNPRGFAFIAVKDEDVEAVIEGADGKEFMGRPIAVNHPLPPGEKSPKRKERPGRLKLYVGNLAFYTSSETLSEVFSEFGDVFDVYIPRDIETDRARGFGFVSMGSEAGNAAIDALDGCELDGRIISVNAAKPREEKQNSDSDSEQDEQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNN0</accession>
    <name>A0AAD2CNN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNRLRE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033679">
        <property type="entry name" value="DNRLRE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042068421" description="DNRLRE domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42927" checksum="78246045880D1D80" modified="2024-05-29" version="1">MTRHLLLPLLLSPAFTNAQTVPDGHTPGNTEHQHGFRLCNMKDDKMLVGEISLSQDATLFAGFSSSTASMEKFVAGRTPDGVRRALLSFDLSSVNWPSDVQVACAEVRLAVDPHASVSPPSTNGMTLHEVTKDWTTNGITALDGTNGGDAQHGDATWNYASFPSEEWDTPGGDFAGDTLSRETIVSSADGIKYAYFGSTKRMHAVVNEWIRNPSNNHGMMIKADELADDPVGYNVYHGIENNPSLIPKLVVVYTAPSLGYEHQEHLEHHTQNPISNNLGGILNDDPSNSNPISTDGNINQPTETPTEIGDGQFLGNVKPTFPPINNDAQKQTYVNPGKRQSNSNHEYIAIAAICTVVSVVLVGLSVLSMRAGVPQPPQMSADEVIGSDLSLDTEREIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNZ1</accession>
    <name>A0AAD2CNZ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000968">
        <property type="protein sequence ID" value="CAJ1940861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNZ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="97" mass="11230" checksum="8DAD203F8979A842" modified="2024-05-29" version="1">MKKSADAEYDFLDFWEANQKFFAMKQGTTENLMHFKERFLRQAEVLQDLYGMAWFRDFAVKTKAYAAIASTDTAAQNKFKDDIFEAVLATGFLCNCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP34</accession>
    <name>A0AAD2CP34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS6440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP34"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1939125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="50491" checksum="53ACBD9476D993E3" modified="2024-05-29" version="1">MTEDKSAPAPKSYVARVLLVIFAMVQITLAAGLIIGWPGIAGSMLVEPLENGGAGLTLDQTTQLYGLAAAVNYVAPLFLGLVLDKFGPRACSVLSNAIVSIGLAIFSSASSFSTFALGICCVAFGGPSVQQCLLHIGNIFAERRYFVMGIVAESITLSFAIFPVMDIIWEHGYGFRILFAGLGVLVFLSTIGSLLLWPDAPYEIPKSDDANEEKEKGDDDPDKDLKEASFFDQLSSGVYLRLCIFFVVTSWWGNFYIATVTVELGDQGIFDAEMQHTLTRWLSFLDAGAIIAAPLSGYMLDSVGFAPTAVVTIALGILQQVGLLVAGSSSHVMIGSFTAYAVYRAFLFPYFFASLSRRMGFRFFGFLSGISFCISGFTQFGVAPVALVIEGDCHKIEDYTTGQDVNCSEGSWVTAHWLQIIILALLLLVPFLNVRLEQPKRIQNPEEESTSFLPSSSSEYGSIKSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CPC8</accession>
    <name>A0AAD2CPC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ZSWIM1/3 RNaseH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000764">
        <property type="protein sequence ID" value="CAJ1938754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CPC8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM1/3 RNaseH-like" evidence="1">
        <location>
            <begin position="189"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1938754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="419" mass="48556" checksum="DDBF34C82C5B2F84" modified="2024-05-29" version="1" fragment="single">DGKPQRDSTTAHVHDIGDLCRFQIIVHFHHHTKCWYLRLDAGHNFLHANHHKGLHQIRKSPHDLPLQVLETASNMLNHGTPTTHVRALAQTLTHVNLLTKAFTRILEESLHNGLGGIFSPFNPHGEHNTPGQMLLDWFRLHPDLDFVIYTATLDDSMHRLRLRKKTKTKDGLIDPAKYHTQRLQALVESLTLDTGREALIAVSFVSKKQRRFFEMFPECLGMDVTHGTNAEKRPLFRLVGRTASNENIPLMTAYLPSLCDWVFHWLFDDAMPTLFEKENVAKLRLMMTDKDLQCMAAFNAIIKVYYPYAQIRLCKWHKTEVDLQFANTNRDWCYSFTSSIESAKEEKDSWNVLLTFVDNMDKEGNVTKDLIRFTRKCLATFFNKSMEYLSFRHYMAVPNGDRADNCFVESDNSPIKRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ20</accession>
    <name>A0AAD2CQ20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ20"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053202">
        <property type="entry name" value="EGF_Rcpt_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34009:SF2">
        <property type="entry name" value="PROTEIN STAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="137"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="339" mass="38655" checksum="41B0BAB6B6B00BCC" modified="2024-05-29" version="1">MMPSPKHSSRNLQYITFAGGSLFGFVLSSLLFLSHFHFESTIGASCSGLDALITTASKNHHLKRQRRTTIPSTSNDGWKQINVFYGDQKHIADVTTLPKPYFEVNQWFSQYRQDEIVARLLNSKKQGFFVDLASNDAIRISNTYALETQLDWKGICLEPNPVYWGGLAYRKCEVVAAVVGNQTLEEVHFTFPKAKAPKGGIVGGQFDNKNDDNKFNTIQRRYTVTLKEIFQTFQAPRVIDYLSLDVEGAEDLVLSSFPFTEYRFNVLTVERPSEPLSQLLNENGYSLLKTLKAGKETLWIHDSIREEIDVSALKIDSQNYKYRESMPLERIAPEEMKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS25</accession>
    <name>A0AAD2CS25_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS25"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="544" mass="58433" checksum="AE719264B13D1EF3" modified="2024-05-29" version="1">MRSITPRASTPATEQSSSGDNKEENSVKDTRKMWESRASTGNIGTKLKKATFGTAKTMVDGTKSATKTVVGGTIGATKTVAKGTFGAGKTVAKGTFGATKTVVGGTIGGTKKVAGATFGATKTAGKSARQAIEDVALFASPRVVQQKLNIGKKKLVVPSAFEKNGDEKKEQEKRPSKTPTSVPKAAGFEAFKEGGEKKQEQRPSKTITAVPKAAGFAAFKEGGEKKVTTPTAAAAKPPAPKGPKNMTIADRARAYEAAMNERAKKFDIVPGAPGAAPMKMRGKRTSRLDKFSPLPGRRMHEAKKHSNFPIAPFGQSQQQQQQQQPEKAKSDTDEPTTTDPTEATLSPTTVGSSVTEDDAAPAAAEPTTAEEPATVEKEAEPVTPEPEAPTEAEAENGDEVMEVPVISESEAKRESARASKKGSSKIDRDTIILQEIVEIIRTAEETEIYDEIDDETIEILKESALKSKAYTKRWYDAYTDSFIHCPSLAQTIVDYTLLELAEAKFQELYEEDFPMLYTVGLRGVACNMVGDEEEIPDYIYDMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSN0</accession>
    <name>A0AAD2CSN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS9326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052788">
        <property type="entry name" value="RING-type_E3_ligase_ATL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798:SF97">
        <property type="entry name" value="ALCOHOL-SENSITIVE RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1945182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="183" mass="20006" checksum="386DDE2F975B6B52" modified="2024-05-29" version="1">MSEWGDNIIRNKQSLVLWGSVTVIAIIRYAYDSRCGGRRQVEVPLNPEEAEAQSRNKAAEESLINLLVETLEVFEAPIKAKNGEIAEQEAPVGDIEEGEDSNGDSNEKEVQTFSNGCAICLEEFEEGDRIVHSVTTKGCPHIFHEECLKEVIAASASKGIYSVPCPCCRQTFVETGSSPEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSZ1</accession>
    <name>A0AAD2CSZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycolate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSZ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050155">
        <property type="entry name" value="HAD-like_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434:SF1">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="25848" checksum="8A8CFAA38ECAD9FC" modified="2024-05-29" version="1">MTTNSNEFDLNNVKAILFDIDGTLADSWKLGFDATQVVLESNGVGKITEEEYHQGCIYATPERLARHAGLSPSDPTFDEVGEKLGKEFDDHYVGLVSTDTAGFYDGIGDCLDSIPSTIKFGALTNACVGYAYAVLKCNSNEKNNIYDRFESIKGADNVPMPKPAPDGLLAICAELSVKPEECVYVGDSPTDGKAAECAGMPSIGVLWGSHDEESLKKAPFKRLCKNIDELRGLLGVVPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTB7</accession>
    <name>A0AAD2CTB7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000946">
        <property type="protein sequence ID" value="CAJ1940707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="397" mass="45465" checksum="31112ABAFEFEBB09" modified="2024-05-29" version="1">MNRLTGKKKQRLSATSIFIWIAVGCGIAMLVVSSTTSGAYLRNTMNRKLSEIYEEAISNNSTRTNGLGSMLSLGPEEDRLLISELTQSPPPGSLECPEGFIAIYDRIIPETNSTTVKRKIPKILHISYKSRCLPAEVFGAGVQRWMDELPDYSVYFHDDDAVDRLMEAEWPEFPQLHRIMRCLQYKGAMKVDLWRMLVIYRFGGLYTDIDNVPAEEFKGGEVIDPEDTFFSTSDSWNRPNQNVFAMEPFHPIAIFTIQTIMKNLYEMTSLRKPQVVFVTGPMVFRDGYISYLELSYPYKTHEQILEAGLKKGKLGKQIHKEGQWNWGNIIGSEGVEYDGKNMSKKERDHLLAGTYHWSKVVYWNRNGLDLSCREYLYQLEHPSPENGIAANWTVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTC4</accession>
    <name>A0AAD2CTC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000946">
        <property type="protein sequence ID" value="CAJ1940737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1940737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="208" mass="24020" checksum="69FE0C738D922927" modified="2024-05-29" version="1">MEACMQRFCRPNIPNLEFYNKGHHAGFLQALNVVNWFWRPTTKRPQKHTCLCPIKKGWSPTKGSSVLETFQDGNQIAGVDDTKQGYLEEAFDQDYEPEDDEEDDVNLCGQFDDINHSKRDKLLETFQDGDQIAGVDETEQGYLEEAFDQDYEPEDDDERDVNLCGQFNDINHSKRDKLLADADNDVNDMPELTVRFRGDDDHESDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTD8</accession>
    <name>A0AAD2CTD8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000957">
        <property type="protein sequence ID" value="CAJ1940773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="130" mass="14437" checksum="689C864835472A06" modified="2024-05-29" version="1">MSPTTFVCETPMIRERPQASLTPPSPPSKRHCSRISYDLPSSPCESLFLPLLSHFDKVAEDDGEINGPFFPTLAPRPTSCFNSFHKLSIKEPENEQPFALKKRSSSMAFNPTSLEPCSNKQKLSVHALCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTG3</accession>
    <name>A0AAD2CTG3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000502">
        <property type="protein sequence ID" value="CAJ1935723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTG3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="669" mass="75245" checksum="EB29622C3627B892" modified="2024-05-29" version="1">MIVDRRGVGAQMVARYPTQPSPVPVDPIDQDNHHGHEDQSADDLFFSLTSSQMAKLFRAKKSLCGQPVTLTVNGTVFCWRAVLMDADDEEDDEESSTTESTNELILFSVIVALLLPVSHTSVPFTWHEGTFEDHLDLHQFLKEATASETKRGSSGDIREEVRSTSSASLSIRRVHISLARLCRVLEREEKRCHYVSEQANVFLKIRSEQQKKWELQKVVANSSISTQQGSNNPASASSSVISSSTTQTGRPRRSRHSRQQSIGDEILLHSKSTPTMKEEQGNEQDILELMLAAFQHGTDYLVDDSSRQHNGNLVRELVQVFHSLSRNDYEYPPTAAALLCERDGVVHINSHIAVPIEAASIRTSQSSLRPYFTLLFPHASPSELLRTFQSSGSAAPQRLQQLLKTVNPQKSLSEIAVDANLPLYTTMEIASYLVAHGACVPSPIVSRKSRLNCLHVEKIPQLALEFSQTFSNVNFFRLLGFLTSSQTLGEAMEQMTDLGDDQAAWLRECWPPFKSILETTNATNVAMTYTPDNQARQSSGGPNQQQQPKRPRHRWVDELEEFLYAMTVWLLSHRVLTLTQEYLVLDGSVLAGEPPPIPPKNRSMTDTDEQFFQELTKLDFLNGDISIMALSWRLGLDQKKVRSWGYRYHKVRVMSRIPAPGDDWELELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTM8</accession>
    <name>A0AAD2CTM8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001470">
        <property type="protein sequence ID" value="CAJ1945724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTM8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="113" mass="11516" checksum="8E7B3A8BED138588" modified="2024-05-29" version="1" fragment="single">MDDPAASKKQPASSSADSSAIYTTITTTPTANLSINVLGLALVCVTPMALGFVYGFDIGSTSFVLALLLKEGGADGGGGSEIVWWSHLTSLQQGLFVSALSLGALIGSHLMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTT8</accession>
    <name>A0AAD2CTT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homologous-pairing protein 2 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS5067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1936189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="61509" checksum="D3305BBFD29E0D1F" modified="2024-05-29" version="1">MSSTRNLPAKKRPVGGYIDDYSIGSSVSSSASSASFQMEENSSDEEFDNEDCDDKDKDKDKDKDKDHAFQVNPMDSQESNLTAPSPLCTQPVARPAKKRRVSVSPQDSLAKKVRPKSPPSITMMEGTSFGQFTVLSNGDDENTSKPKPKPAETSTPKLPSKPSAASRVHSAISEASNESTIAKRAKKMSSQKQSYEVENEVKTSTTMTPTERKNTKAKKTKTSLQSIAESKVSESKAPGTRKTSPAKIAPNSKVSSTNAATKSMASPAKTSLVTAIETPDVKAFAKQKATSVRKKTGAEDKKTADTTEMKPKADSSKKRKKKKSFQDQLLQHLFFSGRPFTVKELTQYLKTSEASVNFCLLTLVDKGWIIKKEFTSKSRSRELYWANEDSKNKELMAALEMVPPHEVSEARVKLANLQQQEKATVMELHQVMQEPSNEELNEKVVNAEKEVASLQIEVDAILKRITAGEQTVVPKQKFGLAQPKVCKVKSNPTRVKVEINRMRGEWKKRKEKCTDFIECLADGMDKTVKVVIKLLDLETDEDVGVKMPPKYEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUE2</accession>
    <name>A0AAD2CUE2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUE2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="456" mass="51932" checksum="32657092E1755859" modified="2024-05-29" version="1">MIPLAETNYSMISDDELTRKGCGGEQEVLACSICSNDLNEVPFNSSSCDSGIGTSTVSQPQLIPLDNKESNAELSGLSPPSLQEANDRKKYEDIAWTELPSEIREAASRLGYTEDMWDESKEPKISTKYWAELDSKEKEAATVLGYDETQWNFGNKKVTPGEYDDMDWNQLPKNIRKAYRVFGYSKKIWNDDDAPASFDKDWHELTEAEQRAATIIGYCEDTWDEDPEDEQPRSIEEESIDFLRGASYILLECISTAAFSGCIEMIFSVGKRILEKNALNALKIVIGLAIMQFSGQTHRWLKGEEETMTLGKNGGGIKHDTLSRSFLNLFSWWTIFAGVEHFVGAFEDDLLYKYADTQWYLNLCELEKKVNNTCEEVLWNVTATENMACLTVPQEPANYIKYINMVEDYLVDTVCGLLDDEKEVMGQLYYWALYICSAISMWYVFDDNFLRGCDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVU9</accession>
    <name>A0AAD2CVU9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="569" mass="63886" checksum="A162F9C5A7BE3636" modified="2024-05-29" version="1">MIATQLQKGTLTPYLLTLVIVVVSLQAVLINGFVPNNNNNNNGAGLQIHYHPPQQESSRQTLQTTRTVSQLFQSYDDDDDDDGSSTASSSSSSSSSSKPRTNVKLPLLDWLEFEQSVLAKNGDVENFILPLPSSQLPTELSTPFLYGIQLERPIDKLIMEEAKTIHDSGENYNNSDDDDDDENETPSSSILTSNKMSSDRRPIFGRLVCKNDSSTLVGAIGCTAEIFISSPMDEMLQGMDDDFDFDMNMMMMMDDSDGGAPSDTPPTTMLCRGDFRFVVKSVVQSIPYPIVIVDELVDNDDDGSDDEDTQTSTPIDNDHDDEEDDDDDDDEYLDDYDTMPAEELIQKIMSIVQKVITQKVDDAESKERSLLEESILENTTTNDDPSKVPLDLTTIEQYQAEEMAAVWEIFQSSMIDDIEPSQRRFVLSMMAAELASLDNPARTRLLQMTNSLERLRFLTGKLDQVWGMQQARKLASQITEKTDEDDKDLKVGLPTLPPWAKTIHKGSRVEYYWNEEYDWVAGEVMQEPTIEGGAFDELEVMLITVQFDDGEVHTIPLSGEDKARWRPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYE8</accession>
    <name>A0AAD2CYE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS9842</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001458">
        <property type="protein sequence ID" value="CAJ1945697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="359"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="980"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1945697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1310" mass="145644" checksum="71B4AF41F6C16A5E" modified="2024-05-29" version="1">MERQDMEGMESMESKSLLQDVGNRREEMSLNIADGYILVPLRERHMFLRLDVWPFLFCYALLVILDFSNDALDGSFTLLYVLPQMFFPLVLLAHVALFLLCQWDIFWRASVGYQRLSMKSGKSSWTHCLVEAPHIDKHHAAHDAGIVQIRRQNNVVACRFQDVIFRCANQETDADITLWDVGRTDENSGHEGSTFHRLRYPAHLPLSFYHQWTGHRSLQNLVQAQQVYGNNVTSIRLPPFLEMLQEQLVAPFFLFQVLCVLLWCLDEYWYYAVFTFFALLMFESTVAYNRLKSLERLRSHTMHGHEKMIYTYRPAFPPGATGWVRIGTSEIVPGDIISCREATARRGRNMAHHQKQYLNRVPADILILSGDVVVDESLLTGESVPQLKTSLEETSTDRNLDLQEHKQSICFGGTNLLVTHEGGDTRFPAAPDGGVIGVVLRTGFETAQGGLLRTMAHTQKSVDGIHTRDTYIFILLLLLCAILSAHMVWEEGWADESRNRFRLILHVIMIITSVVPPELPMELSLAVTNSVTDLMKRCHVYCTEIFRIPIAGQVDVCCFDKTGTLTSDEMQLKGVRLVDNGSFQEVMKTNESLPVEPTFIMAACHTLALGGDESNNVIGDPLEKAIMSTTGYRLVKNNELQREAVSENRASMIQIVQRFNFTSRLKRMSVLARVDSGDTVWALTKGAPEVVKKLLKEGTCPDEYDKVSMYHMGRGQRVLAMAYRHVSLGQDVLTLKDLKRDDVECNLIFAGFLLLDCPIKGDSKSVIQELQSSGHNVKMITGDSLWTAAEVARQVGIVQKRNGSFPQFFQLERCHSNTSNASCKLALGNFRFVSMIPDSLCGTGDIGVSVVASDLDRLKEMVESGDASLCISGDALQDLMSGLVGGDKPNFVSSAVLRGEDKHALFDPAAQAVLKSLVPLVSVFARHAPRQKEAIVAAINLGGFKTLMCGDGTNDMASLRRAHVGISIISAPGVEAKQRSATTKISSARAKQNKERKKKNGTAKLKASNASLQDSLNQLREAQEELNSVELGDASIASPFTSRSVSIKCCKDVLQQGRCTLVTMLQIYKILGINCLVNAMVLSNLFLHGVKQGDRQLTVTGLAVAALFLFVTRGKPLDSISPIRPPASVLCRSALTSIAMQFGIHFWAIRLASQVSLSFVDPYDPSMIPDGPFNPNTLNTSTFLMNLLATVNTFAVNYRGEPFVEPLEKNKMLLRSLQTCYAVLLCCALELFPPLSDLLQLSEYPSVASDDAQEWQKDSRSTDLILSLANRIVSSFGFPAFMCGLMLVDTSSTFAVEKLILRLFEPSSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D187</accession>
    <name>A0AAD2D187_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS10372</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D187"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="27"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="12">
        <location>
            <begin position="679"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="13">
        <location>
            <begin position="822"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1946231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="962" mass="106338" checksum="F67BAAD4399B349E" modified="2024-05-29" version="1">MPPSNSNETYCTFTLAGDVTAGGLPSEAEIAKDLENSDDNVKKHALKAAIMAMLGGEAMPRILMQVIRFCINSDDKQLKKLCMLYWEVVPKYQDMTSDELMQKAAGQQVSRKLLPEMILVCNALMNDLNHPNEFVRGSMLRFLCKITDEEILGPLIPSIKACLTHRHAYVRKNAALTVFHAHKLHGDHLLPDGSDLIAEFIASETDTASRRNAFLMLLHENEPLAFEFLGQHMGDGISKFGDGFSLLVLELTRRVCRKDPTQKSRFVRVLFHLLGSESAAVSYEASWTLISLSNSPTAVRAAAVTYSNLLNGQTDNNVQLIVLDRLEALQSTHAKIVQELLMDIMRALSSPNPDICEKVLKIAMDNVNSRNVESVITALKRELQKALGDDDEKSMAVRHLLVDAIHECAKKFPHVAESVVGLLMELLSSTERTSFQVAMFVRAIIQEHAPLRATLLPKLVDSLGDITSPPVMCIVLWILGEYTTPENAQETFDDIVKEVGSTPFAVAEEPKDTPASEEPKLVTKNVVLSDGTYATQTSYSSPKPVEINDNMPKLRKMIVANGDIFVAETLVSSLTKLVLTFPAADKARTAKTVLILCAVTKLAETNRAPNVAQRSSYSDCRERCSLCCRILLDPKTRDLLKPILLEDGKKQLGLYLSKVAESAPKKTKKEDASKTAAQADDLIHFRQLKSMTVSGGDVDLDDGSDLARATGYDKNTSIWDKDNSHCYPLSGFADPVYAEAIVTVHDYDIILEILVINRTANTLADLTVELSTMGDMKIVERPQSNTIGPMDQKTIRASIKVSSTETGHIFGSIVYKDMVSQEQKLIHLNDIHMDIMDYIRPATCSEELFRSMWAEFEWENKVAIATSITSLKDFLEHIVTSTKMKCLTAPPGEGDTSTFLAANLYARSVFGEDALVNVSVEKKEDNDGKLAGYIRIRSKTQGIALSLGDRITSVQRGIPQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCT0</accession>
    <name>A0AAD2FCT0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1924985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1924985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="622" mass="69426" checksum="005C7A53E19EFD05" modified="2024-05-29" version="1">MVASSVPTRVYYIANSKKGIRKDSSKKRHETDDSTTNPTCASQVDQNKRCFVMDMVPQEAEDLEVGTVDIISELVQTYLTEMLCSLGNDNFQFPGEIVIDIQLQHNEYMDCAFLVSGYEVTSMYGDVLFGSIEIYALSGNPQDILQVLLQMEMPSFNLKFVDQKYIAEVKDFLSTNPHLRKLRIGDHYLENDQHLVLDVVKSSRSLSTLQFGGVSFPPKEIGMNQTFNDYMRQICESKSMKKLDFVEIADLSQDHIDCLTECLLEKSPSNLNAIDLSAGYGSKHLTVNIAKLAGVLRHIDTFEELIICHRILSGYDSIFECANLLKRSSCLKKLDLSASGGKRLIDPDAWTCIGEALPETCSLQYLDVSFHRISESSWRALGEGLKVNTSLLTLKAGKSYDRGGNKEINILLPVFEALHENITLQSLHLNGYDLSDSISALEVLESALIQNTALKSLQLKDSSMSDEGVAILSRSLPKMKSIRKLDLQYHGFSLDGAQALVLGIKYNYSLLSVAAGTKARLGYSCGYVPPIAAEGFAKEYHEIQYYARMNRKGRRCIWGETPIQPSLWPSVLANAMNKEDPPGGPLVNGDVRNKDLFAGNHDTSIDVVFFLLRNVMRFEAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG59</accession>
    <name>A0AAD2FG59_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000691">
        <property type="protein sequence ID" value="CAJ1938236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG59"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="107"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="206"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1938236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="304" mass="33278" checksum="17BC6287D35C4112" modified="2024-05-29" version="1">MESSKEEVPQWHNLVAGAVAGAGSRLATAPLDLVRIRWQLEKTVTYPRPTIFQALSTIVQNEGGVSALFRGSVAATYLWVGYSMVQFTVYGRIRTWFESQDDQTNPHPTLVSFCSGGSAGVVATLLTYPFDVCRTIFAARGVALQPLEGKSRTFAPPKTLYEFAFSLYHKRGIRAFYAGYSPAIVQIMPYMGLNFCIYEKLTQGDKGVAKSGLAGSLSGAISKVAVYPIDTVKKRLQAQAVFGATGDHYEGMVDCFTKMLKKEGPTSFYRGLVPSVAKTAIATSLTFSLYRGTKNILEDFHKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHI9</accession>
    <name>A0AAD2FHI9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS2722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000213">
        <property type="protein sequence ID" value="CAJ1932175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHI9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1932175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49195" checksum="87732D704A417E4B" modified="2024-05-29" version="1">MTSWGPPKYVYQNLLDLKEAPGAEKEREEDRYPNYCLSWSKHIYEDKKTGKKLQLLACCGGVKAQIVAVERDNPHDPLRPWSTFIDVDPDEKFRASAFGGRSINGSPFLILGGKAAIIKLVDIDKRCLAHTLEGHRGVINDLKVPPSDDSFLLSSAGDEGIRLWNLDVRACVAAFAGTYGHRKAVLSLSWHFEGKMFASSGVDGYVRLWNGVCDVRFTGASHVSRRPIPDESVAKGQPYYDQFPKFASNKLHVSPVDCVHWFKDGRILSKCIDNEFLLWEPDFSIEDESQPQQEVAGHPPAKDVIVFMRFQVSGRRRNYFSRFGVDPLDEQLAVGELLGTISIWNLNDAVDNAPFDDDDDCAFEDDGCLDFRIDPYQTLNLPNHSDKVRVVTYAPNGGNKMLVACSDEGNLFLMENSNMSQIGGTNEIDDSESDKGFVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHJ8</accession>
    <name>A0AAD2FHJ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000804">
        <property type="protein sequence ID" value="CAJ1939541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="141" mass="15698" checksum="5117A74669ABE713" modified="2024-05-29" version="1">MSNLLTPPDLVSKRAYSQWGSPNTPKAFSDPMPHRIGARIETEKGIRRLMKDKLARGLGIQKGAEEGLAAHSLHQSTSLFHWEYLSYLMERLKDHGTPGSDHGPRPTSTPMRNPPLPSPRTRRSSHGAPPPCWIVAPATYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJF5</accession>
    <name>A0AAD2FJF5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="248" mass="27167" checksum="BCF8406331EA4FBB" modified="2024-05-29" version="1">MPVHPASIPTMVKRKSKAVSFASSPSQVLQLPETEETELRSKWYSRQEYAGFKAAIINSVNAVGPTTAGGESVCSRGIEFMTKAGLAYRKQTKLKVLAAVWNCQVRQWNEQNRIYDPVSIALACQQETLQCTYMACTLGQLDQQAAIEEYQRTMLFPSQTNQTNQANSYNVGVLLNQSNSCIGGDLQKEPSEQSRVFLQTSNNSGGELQKCPAKPVVTLAGKRALKFSLDGSSHGLRSPTKRLNVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FK82</accession>
    <name>A0AAD2FK82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001302">
        <property type="protein sequence ID" value="CAJ1945012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FK82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="29070" checksum="ECA66A305874A357" modified="2024-05-29" version="1">MQGMNEWRTVQQTIVDGERFFQQVGRMDDDARFADVPVRPSFVSTERHTKATAETLSERLGIGLHRARATLRSTLQRGTRSAILPLARRYRADRMFLRPRLKGKFSTDTAYFNHKSIRGNIASQIYFHKSGFYSCHHLSKVDEKQVGPTLKKFIADYGIPEHLTMDGAAVQVGRNTSFMETINRAAINYNISKPYRPEENPAEGGIRELKRRFYRLIVKHAIPERLWDFLLDYVVDTMNNEHHRQLLKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL19</accession>
    <name>A0AAD2FL19_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="247" mass="28155" checksum="A2FB371E7B9F32AD" modified="2024-05-29" version="1">MKYNFQKKMQSPRLSMTKNKTMDSDRRSLILQSMDSFLGIDEDELSLGDLPPVNKPSIRKPGALTRDDRSTSTEVTALDDSVASFDLTEMEKEATITILPVSPFPESHPEDIGEVQEDCFDSDDDEWSTKSLEILELRKLSHRRSVSIQSVEMDENCLRMPDLRKSSVPPMRRTSISVPVAPIQETKQPSRRSSVSFAEMAEVSFIDKLDAKNTDFDSLYWNEEELADFRHEAFLEECGIADEDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLS6</accession>
    <name>A0AAD2FLS6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS8063</name>
        <name evidence="11" type="ORF">CYCCA115_LOCUS8065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tic20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLS6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005691">
        <property type="entry name" value="Tic20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33510">
        <property type="entry name" value="PROTEIN TIC 20-II, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33510:SF5">
        <property type="entry name" value="PROTEIN TIC 20-II, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16166">
        <property type="entry name" value="TIC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042440664" description="EF-hand domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1942670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1942674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="381" mass="41154" checksum="19AFB57A323EDA96" modified="2024-05-29" version="1">MKIQMQTSTLSFLLLAASSQAFAPSSGTFRSQRIDVDRPSFVAPTSSSVLFASSNSTLPDPSDAQVLRAKAQQLRDEASELATEQAQKVSDAAMKVFAKFDTNKDGTISAEELKMGLEKTTKTSISKDTAEKLLQQLDTNGDGVLQKEEFQPVDRLKNQLDFILRGEKALVLNQGKLAKQIDFEKNLRAKIISLINDGEPTGKDKVVSVLPYIFPLLDSLAYAAPWIVSHQDNPIAHAAAVAFTFYRSIPLSGFLAFFALSYLSTDLSLNRLVRFNLQQAIILDVALFVPGLMIGLVGLVGSGLGAPVPGVASEYLSDAVALGTLATIAYASAASLTGNTPDQVPLLSNYVKNRMITKDMFDKKGRFVGPGVEDKDVNNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMA0</accession>
    <name>A0AAD2FMA0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="327"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="428" mass="47101" checksum="2ED5FFD2ED498895" modified="2024-05-29" version="1">MVKQTKGKVTKLQVCLHKPTKESVLGIGFCREDEDDDLTISGIAEDGLVFQQTQLKPGLKMLQINGLDVQKADPVEIATILKEAPPGNITFLVKGQGLEHVKDAVSYQTGLTFREVQGVKGIMIAGIENESMFAYNELEVGSLLQSINVEVKPTTSEGAMRAMDVALPGKVTVKAERMVQTNLGIWADRRHKPEQQPVEEKKTQEMTVQKVGVGQYMDSQLVLDGAEEDMTETVVKPTADADMGLIFEQRGRDVIISKIVGGTPFSYSPIQPGMRLESITYTNEVATAKDAAFTLDRLTMIDGVEMALDAEAFVATTHKTFQWTSTGLKLMDSDDGVIIHEIPHGSHFDKTDLKVGMKILSVNGRPCPFTAYQVVDQIKKATGKIKIVAQFPLSYVEVYKQAKAREREIETHKDAFFLCGETPSLFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNI3</accession>
    <name>A0AAD2FNI3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fucoxanthin-chlorophyll a/c light-harvesting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS11131</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The LHC complex of chromophytic algae is composed of fucoxanthin, chlorophyll A and C bound non-covalently by fucoxanthin chlorophyll proteins (FCPs). The ratio of the pigments in LHC; fucoxanthin: chlorophyll C: chlorophyll A; (0.6-1): (0.1-0.3): (1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNI3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="5" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042120108" description="Fucoxanthin-chlorophyll a/c light-harvesting protein" evidence="10">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1947407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="20972" checksum="DC3E54A3E3A8E6DC" modified="2024-05-29" version="1">MKTAILASLVATAAAFAPAKQAAQTSSSLSAFQNEIGAQMPLGFFDPLGLVQDGDKANFDRLREVEVRHGRCAMLAVVGWLTTAAGVRLPGMEEVGAGFKALDMSGLSTEVKGTLPLTLGTVFLLTVAMNDQDGTSEFPGDYRNGFVDFGWDKQSDSWKERKRAIELNNGRAAQMGILGIMVHEQLGNLASIGLPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNX9</accession>
    <name>A0AAD2FNX9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNX9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="754" mass="85561" checksum="76942A398FC54C30" modified="2024-05-29" version="1">MKFQGEVILILICAVVVFFNSIFLFRSNDYPCKEPEKYTALGNPHQLLNNKRGPRILVGISAANFQKDTQTFHDAVRKFHQRFSSEPSARNSNKEWCSLYDVMIAGETFDSDSHCHCTLVYTFLVPTHSGASKPTNQISINQIEVANTLYLETTDVSLMEKWMEWASGIQVGKFDYVGFSSLESLDEESIVWLKEEVLKKNQDSTIAATKASNQQDCISNHCMEFGFLCFSMDLVEILKVRSFSPATRNAELSGISRLFRSLTEGRSQLMSTQDFKIKSPSKETEMSLSKLFKIQEVSDTQLDLPVKTSRLAPGLSPVTAIFMNGYLHDPSYLWAFSFPRVLLKHMSIHSSNTSRLRILGHEARTEKLWRINPLLNDDSTDNTTDLVEVLEGGKEVQNQMDIIFARNIAIPGLVLNHPDLFEFCEYHRKPRKHRNRKLPKTTNHSTCPVIVSFPIGTKPCDHCSPEWHLEIPDDQHVKTLSNSHWESISLIQKHLPATGVVPVELPNELLSLFDPSRWKFITSKGCTVAYVSRWNERKGQNRMTKEFLEYSKAGLLNNISSTTICFAGTAEGYEKQKEGIIRQLNAKFETIRAVDLGFLSFAEQILVFRLAGKSMLWTDYDQSPRIASLSLASGARVLTTELAQVPSPIVDDDCMVTVLHLFDNHTNSLEGRASIVTDFLSKEERCVKENETLTRAYPILQEDSFYGPIIERAMSMWTQLNANKERHCIKLFSHVCELFGMLRKVKKEGNCSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPZ1</accession>
    <name>A0AAD2FPZ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPZ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1067" mass="117720" checksum="22CA157C2A9BF47F" modified="2024-05-29" version="1">MFSPRIQIGVSGTPTSSAAPTPYQSETNDESSEEEFASSDEEEADLDSKVQNNGVSSTCLKNIQDHESMEFPINGECTSLSLSSSGNFLWAGFSDGTLRVFDLTGNFGLETDAAVASRQKSSLLVASKWCQTYGAVACQIHARGVHTDLITQVGVCDDYVFCGVSRGAMELYAVDFRDLEASAKGRVTKKENILDYLHVHEKADAKLKGFGACTRLKNAARPTYLLLTGKGIKNIHIWSFQPPLTTQEEEEPIWSQLYDTQTNGNTINLLGFYRPPAQNKLLGVSQSDSQKLRLWDLSSEEGNPDETKERAKRPPYVDVANSKAALGLAAGGFCVCGGPTMYNQLSIVSLDQPKNAYNHTELALPAGDGVADDAGGSRRSSSRRQRRGDLKQVANVASPPEGDANAGHVLLELDDGTIVQYTMSNTMASDGKLQILQSPTVPALPDDYWKRTICLASSRHHKGALMVAMSLYNPNTQRGKLVLRKLPGTEQDTASSKELAAASSKTVLQTPPPRHSTVSQPKPPVNAASKASPETDLAAIKTLCMAPPATKKSKSSKSDAERIKSKKERKKKRKQEKLERELLQNRRSDSELCVVESFKKLKMAESKRSLNLEADTLWKPKDKIKKKKQVVPEMMTPARESSKDVSNSYSSAERILVKKVKVIPLSGEKKVKKTVSAGSSPTNSVSISSPPTESDNSKNGDDFFETPAKKNPNSLSSSTATDSNSADTKAASLTTQVSPDSSVIQIKPAKTKTTGEMDRFVVSQKQLKMPQPPKKERSKNKPPKLTKEQKDRQEQLKVTSVPRKSRPNDETIAEEVEKEPVDETNTPDGAEIMLEEVHEEEVSPETTTKSTSKKKRPRFVPTVSTDDVESRKRKAAPEPEPKTPPSKKKFSAEDSPPTREDMHAVRVKAEYKRIQDLIAHLPAFVPVLLRQEEAPKTPAKSITENQERQRSKLESKHRAAHEMIQRRMLRAAESIIRNAVDFHLTVEQARNELKGTVQSYQEVVHETLQRHKLESQTLVAQQKRARGGLDVPCVQVHFPFQSTFSDLEDARRAIEAPRRLPGRPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR14</accession>
    <name>A0AAD2FR14_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="648" mass="72583" checksum="52D1CD4D33F2E162" modified="2024-05-29" version="1">MADHREEDSPPREISFLQQQQLLFRRAITHFTNPDLYLYTGQTRDQIPDDVLNVRVDPSVRVIEWDTFAGCGQMRSIELPHGLVRIMGRAFLDCYALKDPQIPPTVKEIGDMAFSSCLAMNSLDLPEGLERIGRAAFPSCSFRNVKIPRSMTEVGDKVFSCCTDMISIEIPHGVTAIHSEAFFQCLELRNVAIPDTVNVIGENAFECCFKLQDKFPEEDSLVEALKTRFDDLPLHKICYYQAHQSTEETLQELSEAMMDMDALETVGGGVPCRVQQDAFGLTPLHILAMSKKQQGNMELYQFLVETYPEDLTVYDTWGYLPIYYACLSDAPLEIAQYLLDTHKRLSPENAVEEIPWHAIVDSFSIMFVSAAVLKCVIHWTIVDRLELLEYAPWREAIIQSIDLIPDGGRKTWKEKDKQVNAVYDLVNLCELKELTSILELVAWKSKVDQTTNTTSQGDVDGKNQHQHQQHVELPVVLEVAATATADSDSNSAAEQQEQEDEKNNDAKEVMVDPSKRLSSSTHTTHTTTRSSMETTASSTADRYSILTTERESIVDRSSIISKTVVEEEEKSSTDGAVGAVGGGHAQDDDDDDDDDDEEVVETDDPEALAMRNNCRINSGAELIISNVMPFCRCPVQLQAWDSSSQGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FST4</accession>
    <name>A0AAD2FST4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS13528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FST4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="7">
        <location>
            <begin position="42"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1952388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="601" mass="63556" checksum="6EFECBFABE381008" modified="2024-05-29" version="1">MTSAQESGTNLTCDDGSQSPSSPQSASTTEETTIRAVNVPMVCCALLASMTTGGATYAFGLYGGTLKKNLHLTQAQLDTISTATFFAGMLSWLPGMFIDRFGTRLGICLGGLSGSCALMLYWIVSKGMVILPTKGEIVGVLSVLGVATFLSCALVTGSVFKIISCSCGAGTKGAAVGVAKGYVGLGAGIYTCLFHSIRQPGSSDLDFLPMAATLFILAASTPSLFLLPSAKDDGKVDDVLTPLHFRVLYTALVTLAGIVVITSLKELHESHNKQHTSTHNYFLAAFILLLWTGSIGVQMFLPHNESTLLEEEEDQQEQEDLLEPLSGFGGLEESLDQIASTCSDDGSSAAQSSSQATVVHSNTNKNLYQMLQTPEAWLMLWTTTILVGAGTVETNNMSQMVEALDYSPDVTSASLALFSVAQALARVATGAISEAALNWKGNEWWGYGGVPRPFFLVVASAVGIVAHAILALSVHESMFVFGVTLSGCSFGMVWPMMVLIVGDLFGTAHVGANYLFFDGFASAAGTLLLSKFVAQMVYERHAEADSNDNGGVEICSGQACFETTHLIISALSGTCLVSSIAMLRRTRHAYSRNNASPSRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSU1</accession>
    <name>A0AAD2FSU1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001788">
        <property type="protein sequence ID" value="CAJ1951585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSU1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="222" mass="24589" checksum="3289EF2EA1FBC4A1" modified="2024-05-29" version="1">MLLSATHWVWTGFGDSEGSFKPPSVILFQGCGQGNGAGPPIWISDTATLWARGIRATGGAIKPKKSFWWLIDFDWDSRIGTWKFRGKKVVAPDFELQIQGLSGATKSLRRLEPDDSERTLGVMLAPLENLKAHERQLLAKAKNCAEQLWPNLLHKYDVLPLTRSTIMKKLEYPMALTTSDAQQWADIMSLVLARGRCMLQFPSGSSVLSGSWTPTPICVSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT24</accession>
    <name>A0AAD2FT24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS13442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1952222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="697" mass="77470" checksum="32225201112B01D3" modified="2024-05-29" version="1">MPQLKRSIGDYDGDNEAHDKLHASADFNGPVEERYCTDLLWLILLCLCWAAMTAVGSYAVYNGDYRLVLYPLDYDGNVCGADLNDRDMTEYPFLYYTNAVGGVCVKECPSLVGRTADNATDLYTLVTYTGVYQSTTGLATVSADIVQVADYSYTLNRTGDDSNSTSLSVTLIDTNNFQCTEDLCIGDSLEASWKTTGINRGFGFAYYLGDSFPLFQRCFLTSEARDQIANLTNAAGDADDLFEDVMSKSSDLEGTTDFISNLYGDLWTTRLYILGFGFGASLVISLCYMVLLRIPWLLSGLIWLSIFLMIAMFAFAGWFAVGKADEWEAENPPVVGEDQVTGTRIVGYVLYGIAAFLFLLAICMRKQIQLAVMCVKKAGAAVNDMVFIFAIPILQGIGFLAFTAVWAWYGSHLASLGTITLETMDVPLTDYAVPVRSYEYSKDIRQLGWFLLFCFFWTASFILAIGEMVIAVAVSKWYFTAERRLITQHLPFSALWTTIVYHLGTCAFGSLIIAIIKMLRAILTYIKKQISEMSNEKVANCLLCCCSCCLCCLEKCVEFINENAYIQCAIFGTPFCESGRKAFYLILRNAARIGAVSYVSAAVLIVGKLFIAALTTFLAYYSLTEHLELEVWSFAGPVAMIFIISYFMADMFMDVFDISILCVLHCFIADEEMFDGQARYADGNLKEFVDKHGGMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT32</accession>
    <name>A0AAD2FT32_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS13571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT32"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="647"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="660"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1952474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="886" mass="100401" checksum="5344447F4862A855" modified="2024-05-29" version="1">MPDNNPQNGAGRPLPKKEADLFKNVIKHYETKQYKKAIKQADTILKKFPNHGETLAMKGLVLNNMAKRDEAHALVKLGLMHDMRSHVCWHVYGLLHRSDRNYNEAIKAYKQALRIEPDSLQILRDLSMLQVQMRDLDGFAVTRHNILTMKPNGKINWLAFALAKHLNGDLRGAISVVDIYLGTLTEGAPELSRGFEASELAMYRNQILSEIPDNTQEALEHLETCKALVVDETSWLISKARFQLTLGRHAEARETALSMFKRGMTENSRIHSLYMCAILKLDKETCDKAYELPGTRSLASYLPLTSEQKQQLLDAYANEIFPDFERSAAVKRIPLNLVEGDRLRKSLGVFIRKSLVKGVPSLCRELSSFVLIEKDGRFEIASDPIDIKEHSAFKLIVELADEYISCLQANSKLLADDEFEESPSTELWAWYLRAGLHELAGEYESGIALLDKCIEHTPTLVDLYELKGRLLRSSGDIKTAVDTLDKGRDLDRQDRYINNQTTKYMLEAGMDTDALDRISMFTKHEGNPEANLYDMQCSWYELGLAACYARQEKWGKALRKYACVVKHFDDFHEDQFDFHSYCIRKVTLRAYTEVLKFEDNLWSEDYYFSAASGIIKLYLRLHDNPAITKEDAEPDYSKMTAAERKKAKAIARKKKKQAEKKKAEGQKKDDANGDKGDQADGSKMTDLDEDPNGDEMMKRDPLEECQKYSSILSKHCPHKLETWTLQYDVAMRRKKWLLALQALFKLNRMDSESAAFFQRVVDFGLKAADFGEQAPAVKNVLKDGCVELLQKLSVSDYIKQAVEKVQGHKTASLPLRVAVAEALVLINTSSVDAATALIVKGGLDARDASVESCRKALAALKGFKSKSVQDWVSVVKQQYPRIADFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTN5</accession>
    <name>A0AAD2FTN5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTN5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010765">
        <property type="entry name" value="DUF1350"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34127">
        <property type="entry name" value="OS04G0405600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34127:SF1">
        <property type="entry name" value="OS04G0405600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07082">
        <property type="entry name" value="DUF1350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042240979" evidence="2">
        <location>
            <begin position="25"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="454" mass="49438" checksum="FAA1F27930A18DBF" modified="2024-05-29" version="1">MVTIRRVQLLLAVCLSGTVKFSESFQSSHIARHDNPRCQFQIPHHTQKNPYSYDSSRLDAATVSSSTSESPSSETKATKSSVTGKVGNWEEIHGNWVLRPPSSETPRALLHFLGGALVGAAPHITYRYMLERLAEKGFLVVATPYQLSFDHLEICDDVITKFEKLAPSVARQYGALPVVGVGHSCGALLQVLITSLFPDTPRAANALMSYNNKPIGEAVPFFEEVFAPAFSSLAAPNGTLPSSNEALKMGINLARIATEGELPSDQQLQQLVSFLPPFQTNANIKIPKTFRQSFEKTFSPSVEALSDAGVLPILNQLFVSLEQIPKLVDEVATGARDFSPPPPAVKASVGKAYRARRTLVLGFKDDGIDESDEIEEILKEAMSITRMKRPMVGVDVQRRSLEGGHATPLLAPPLDVAARAEDILGSDTSQERLLYTQASDTVDSLIEWLEAGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTU4</accession>
    <name>A0AAD2FTU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1995 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053021">
        <property type="entry name" value="Chloroplast_ADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018962">
        <property type="entry name" value="DUF1995"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509:SF6">
        <property type="entry name" value="ADENYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF1995)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09353">
        <property type="entry name" value="DUF1995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042277099" description="DUF1995 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1995" evidence="2">
        <location>
            <begin position="225"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1952885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="498" mass="55088" checksum="43D790DA0CB961E1" modified="2024-05-29" version="1">MVKITSYLLIIILAVLLNGSCAFMGGQWWQTQGRVSTPPSDVGRSFQMAVTSSNTESRQTLDEKQIDFTRGYLNKHHTDFIIAVVETFSELGAIKSKKNAWSGGSYVIADAKLVDIDPEGTTLEIEASIKERKNSKVERVSVDLNASPVTKTRSPFASMEVISNSEENPIDDLVRRLNRFCWIVNKPAITGKLIQLGIKLGGDGVGEIKENLFLNQVPHNRYVRKYFYEMAANATLEAVALCSEGKISNRMKLISMFPEMNPAMDSYRIGTILEMARTIAIKLVEQNLRVRICVQGSMGVGIFTAVPKQLNGVSKLLQMMDWQAEAGEENEGMIGNYLNFGAVGKEHVVNAHTAEDGTKVEQDDVFLIIAPQSMVGVDSSIIPALTEMVDAAGDRPVILMNPDLVDKVSSQGQQNVRGRQQRIDFANSFKTIHQFQNIYVSGTSYFPILGSMTKISPLAPWVAHQRRDLANDGGEIYIPVLASEYRPDGEVILESFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUA3</accession>
    <name>A0AAD2FUA3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS14238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUA3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF226">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042101684" description="Fe2OG dioxygenase domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="386"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1953635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="499" mass="57069" checksum="616585B887A770CC" modified="2024-05-29" version="1">MQIRHYLLLVLSVFALLFVSVQGDEADSSEQTCTWSDRHNCGGVYRDANLKEMQVNLVGREPESFFAYVHPDISTFYNKTEGSMAITETKFNGMMGKFVNMAATPITIYWKSHDPRQEPVYISQIEAYGAAGTATYPGHVFLVTPLGDSSIVLHEFQVVKGNSLYIYDPIGSLKEAQKTLPSPELERYKLQYDNLAFNNLYEQFTGRQWLALYGRKEAPRYYMWPAESFGQVHTVVTKETHLLELPSDDRFEKMIPLNCHDPELREALQQYKGSEETLILNMTVVSVAPRVFEIKNFLSPAEVQHVLEVALGMKLSQSTTKAGSVGQERTDDATRTSKNSWLSRHRSPIIDSIIRRSADLLQMDEALFRRRNKDEEYLVPETKIPISERLQLVHYDVGQQYTPHHDFSIPSTKHGQPSRFATILFYLNDVQSGGETSFPRWMNGEKKDILRVAPEVGKAVLFYNQLPDGNYDERSQHAALPVGKGEKWLTNLWVWDPHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUB6</accession>
    <name>A0AAD2FUB6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="149" mass="16264" checksum="1CCB90B9266F1CED" modified="2024-05-29" version="1">MSTAQFAIDLSVSDDENDISPSSGLTTFNPSRKPDTTATNVTTNTSQELAGTIRRTSDNTAVSPTPRKKAKPSTSFALIWVCTHGNGRRTGWRKKDLKLVGIYASKAAAEEAKRKVMSEHERAGHGDICVGDTWEDEIDLLIREAPLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUP9</accession>
    <name>A0AAD2FUP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUP9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042218745" description="Glutaredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="152" mass="15946" checksum="F5D71B25808131C8" modified="2024-05-29" version="1">MKLSSFALALIVALSSTVDAFVPAASITPTRSKTSSTEVHLFDIFNEGKKKLVKSLAGDYDEAAIKARVDGLIADKVLDGMNAKYTVVELDTDPDGKAIRAEMADFVGRTSVPAIWIEGRFVGGCNDGPMGGIIKLNESGELTGLLKAAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVI3</accession>
    <name>A0AAD2FVI3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVI3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="303" mass="34807" checksum="28C578FD8085C83E" modified="2024-05-29" version="1">MPPIVRNSKPEIILINHQYKKSRNQQKGLVERTTTMDNSRLPYDDTLFLWFSCWSGPPQSTSSEVFEEGVDEEGVFEWLTEHVFCDDGSSFFNSESIHLMDPLLFENVCHNFPLGREIDFWSDSIIWNMPEAEVDSATLRGVGYDSFNYTIWNVSFPTYRLGDMDTQRNLQRSLELKLQNNYIAQDSLDGCRVAVVGKEAEFWLSNRISQEEKDVVLSVGIIFLVVQTLALIVVPFVGRKLALRESRRKELGLAATSSEEEVFSSERHSIDEMIRTSKGYIDFDVSQSKDIEQNVGDVERSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY37</accession>
    <name>A0AAD2FY37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001913">
        <property type="protein sequence ID" value="CAJ1956299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY37"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="426" mass="48812" checksum="7134F7621C8E7B41" modified="2024-05-29" version="1">MMATVETALVEIVHLSSSGAQFDLASTIRALLRHLPLQVHRRHVKGHLDKHRPFSQLDWWEQRNVEVDSKAQSYCRLLESTGRSAASNPRFFHEPVSLFIDGVKSSKLDQAHIMELVSLPALRTYWSSKDRLSKQSIREVDWLSLARAMKALPANLQRWTPKHISGMTGVGKFLAIWNRSAKSSCPRCSSCPVEDHLHVPRCSAPTAAAEWSKRHLAFRTWMQTQQTAPEIEAFLFEYLKTVRQPSLGVPTVRAWSRHPHLFQSAISSQATLGAQGLLEGLVSPNWRHLQALHFSYIGSKKSANLWASRLIQQLIRIGHYMWKDQNRLAHSEDSSWYTARKREIDIGIREQFAMGLMDIPPRSQYLFRDSRKTVLNKSLEDCQHWLRLVSRERAINRRSLARQRQMIFDLARPANPTSTRPPGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYE4</accession>
    <name>A0AAD2FYE4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS16456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYE4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042254762" description="RING-type domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="324"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1956909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="387" mass="43554" checksum="0BD3D8989AE02FA3" modified="2024-05-29" version="1">MTFPRFLMLVVFTLATTMDSTLALKVSLFDDNDKESLASSSSSFNLTSAGGTSAMDGIASSSPTNETPTASPSSNNNNGSDNGGNEIGCWTFAPSRSTTYYGNNNNNNNKGGWTLPDAEQEDDALWYVLKISLSVLGTAGLCLLAYVVHRNRQFRLQVEATRRAVAEQRRRRRRRIELRNHLGDAYYGEEDEDDGDHNNNNHDEDIHIDMDMPYTSSRSEEIIKRFYFQTVLSSDKDDDKRKEEDDDSSHDEENPSPQNGEDEHFTASKSADSDDDTAATGTEESKNGSTRTCSTTSQEEEKGDWFFQSYWWNNNETSPTNQECCICLEGYAPRETICVPITTKCNHVFHEDCVVAWLQRSNACPLCRVDLMKAEEQPQQQHQQEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G073</accession>
    <name>A0AAD2G073_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1955966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G073"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="406" mass="44458" checksum="369696961D35741D" modified="2024-05-29" version="1">MQGPIMLTPPSTQSSSSYSYSHSMKSSIGSSRPSVDNFRARAGKRQSKETRTTTSSSSGGASTMHSSQSDISAITMDNFYDEDSTVATSDRSHYRFGPTLDSMPEQKRASDPKKEDVEKSMNDLRFNQSNSSSIDALRLETSNNSSNRFASFSGSSSAQLCAMPRRRSSASGSMGYKPGQPALSETSFEDLNDVEPENDIKSRGGTTEDLKSQCDDTTVLTEMTDSCSMISLQGSVDETDPFQVGLYGDEDIPPAPSESKEKGPNFDSCMSLLGSTDMFDSFQDGFLEEEDLALPPQQGQKNNDSDITKKASNRTSFLRATQGQESSSSMAAMRSSSNSAMFDSFQFGLFDEEEVELPNYRTPRISNRKTNKNTATKDETPRRKSIDMSTMHQSLDLDDVFGSMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1I9</accession>
    <name>A0AAD2G1I9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS17475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1I9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034411">
        <property type="term" value="P:cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1959034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="456" mass="51235" checksum="97E9D6B082E4DE68" modified="2024-05-29" version="1">MNIQASPITWKDQLSVNGNFFVFRSNPSERFYIKGIAFPVAPGVNAEDIILGWIDILHQLREASPEINTIRIYQIWPSLDYSEFLQAAADMGFYLIVPLTSMNGRGVLSREKAAPKCYRRKLFNYGSSVIRDFGKFPNILGYVLGNEVMNSLESWETAPCILAYARDLKREYPEVTLMYAMQHAGIGAAGEPSEAVKLTLDYMSECPEASIDALGVNIESWCSSKQTFDHNPDGSIGTYKELYQHLNHSKIPLFFSELGCSKDDFNRDNELEKGYRDWKQVHSILGSDMIDRWSGFVAYAYDGPLDFKMTLGGRWDGNNTLEFSKDMENYVNELDALDIKYEYHGVSNHTSGTNTTHSITDFCPDSSPASAALSSCCDIDLLPVSKIPSYQSWSPATTSLLVLKCLAFLCLCFGIKSIFSKKVPNEKQPSSELDPDDAQKLLSSKNSEYQTFQQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G259</accession>
    <name>A0AAD2G259_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiosis-specific nuclear structural protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G259"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042263761" description="Meiosis-specific nuclear structural protein 1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26373" checksum="066C2C7175C97D14" modified="2024-05-29" version="1">MKFSNLSVVALAGLIHSTTAFAPLFPANVEVSQIVAPGSSMLISKSETKPVSAIAVDSVMLKTLEDETKAAEQEAKADEKKAKLERKREAFFEYEAKAAAEKEAQIEAAERKALAEALNDKEQAQRLKELEEKAEVDEARALSKQEKIAKQKLIKKLLAEEKEIERKERKAEKLERIYLAEETQEKKILQQKLDAARAEEEKYATIEKEYEKAVELAKEDEEELSLVKKFFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G397</accession>
    <name>A0AAD2G397_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G397"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1085" mass="120395" checksum="72F1AAEF961F0092" modified="2024-05-29" version="1">MRTFKSSESFANHKIQRNSLSFRSTLDTRQFQSSADGQTDTNRRQNQGRPNNSQGNRRKGGHNRHLSPNGILNAKITQQKNAAEVLNLLASTKGALTNVGGGSKLNSINFSTSMHRIGRNVAWAWQNPEGNDRSKILSDPRFALLMASAGEAMGGADVVDDCGRPLRFGNREVSNMAWAIAKLKIAPPSSAQPVDATEVSAELMYAKAEEVRKLVYETAKRRKEGDPNAQNGAWIPALSQLCGYILDHISYRARTINSNRFQLQEYANLLWAMATTKRCCPETFAFVISALLRAVDVEDSAGLRPQEWSNSMWALATSGCMGPEEEFIPFVAKLMDDNPEFVDAFKPQELANLVWGVATILSKRPGKADGPEGVAALRVVRQCAMQLIKRNGANYKTQELTNTIWSFATIGFGLKGGTTSDAGNDYTFLPSDDLEGDMLLMEDTVKVAIRSAKQVIHRFRSQELNNLSWALARLGQKDDEILTMIGNQLADPKRKVTPQDIGTTLWGFASLEFLDESVYRGIAKKVNGRRASKTKPQELTNVLWALATAGMVPKYAESFDTLLQKSARTPPHEASRDPITNVVAIATQELMRRPQDFKPQEIKDSLWSLSRLGVRYPPLFKAIAVHLVGPADDARITGRGLEGFSPQAIGNLAWAYARQAQLASDLSFSRKDDLLIAPMTGRLAHYSASFVDVGESLMQKLFYAIAEADLNVHDNLSRLSPQDLSNTAWAFAIMGMRHERFLSALASQLDSRLRRYMKGEKRGSNFTGQEIANSLWAMATLNYCCSESLDSLQDYVTHELKGKELSVKTMSQLFKRQELANIAWVCAVSDKYPQKLIELLYLGLLGAGENSDPTYVKSIYKDGDMDPSVVMSLLYLQTNMALQNPNHSFVLPPNFPEGWLTSDVFGKHKGIVSSPLGVEDSYELELVSSKFQMQIAQVFDQIGFDHVQELTIDAATMEKEYGVFVTSMDAEMISLDLAQVDTKIGIEVDGPGHFLTKIDNGPTKAAVAGHESSVVFYKGRYQCTFDWNYGDQDINGASAMKERMLKKLGWKLVNIPFWEWYAARGDPEKEEAYCRSKLADAGIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3L3</accession>
    <name>A0AAD2G3L3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3L3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="113" mass="13395" checksum="A4EA5F615E3805A8" modified="2024-05-29" version="1">MSPAVGNMELEKKRSAIRTQLHRLRDRQFGDECREFIRAIRYLRLRNDELRTLDFLARLQTALQRVSNEGSISEIHRMAMIAVQQRRRQRRRRRAPASTGVLGSKNRKRSPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4T8</accession>
    <name>A0AAD2G4T8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulphur transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS19941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4T8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1962961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="41272" checksum="E01D1AC9E1441DC5" modified="2024-05-29" version="1">MSIAYFTPVTGASGGAIVGVACGILLLYCGEVLGASGIVSSIGLNPRKAMTDPGAAWKLSLVSAFMLIGNIVLARHITADSRLIQDPSIPIVSTIGYLIGGFLVGFGTRLSNGCASGHGFCGMARLSKRSIAAVVAFMSAGVATASLLDPKNSFASATSLLRTEKAPALFNQWVGLAVTLPMVLGTVYALHNLRKSYQGLDHEGDGLSTTRGSNDPNESYGAVKSAPLLEGGKADQSEQRIVILDGVRKLKPAVVAGMMFSSGLAITGMVLPSKIFGCLNVLLIAKGTWDPTLMAVMVAGLSVSWLSYQFVSGVGIIENSFAMERPKCSSDFALPKSQNVDTPLIGGALCFGAGWALTGMCPGTALFLAASGCTPVILFFWPLFFVGAFVAQAIAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G529</accession>
    <name>A0AAD2G529_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M10 metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G529"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="58057" checksum="FAD043C0482321BC" modified="2024-05-29" version="1">MSGPSQNLTDEQLAAALQQQYRMEFLQRQEEQQQQQQSQRNLTRIATTAPPETEVVYNGSRDEVYAHQLQRQMHSPSIPSRIQNVGFQASIYDNNANTNTRPDAPQSRPDAPGNNAPRGDIEDVVLAQQLQDEELARQYSRRYNQQNQTIASSGTLFDNYTQTRGTHDVETQRQLSQQLTDAELAQNLAQREQEEALRRDREQQSQLQNQSKWYRRILPLFILAAAITIPLLFVFGVFSKNDVPFLDGFGNDWVDSDPWSDVGSINGNSSITVGDSAVRWANNGNGLNLEIWNAMEDKYDALFATAVANWESGAPIDSLTLSTRRVNYDSECKDENGILKVCSGNYGATKWRGLNEVKLNSLTRIIVSSVAKMNNFYLDTESEEQRLYTICHELGHGFGLPHWDVDFYNRDLGNCMDYTIRPENNMKPSTSNFEYLARLYGGRNVATVSAIQAPETAPDSENEFDLGKKDKKDKGKKGERRRILHKSDVEEVHLVHLEEEGMVLLRQYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7F9</accession>
    <name>A0AAD2G7F9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS20630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002184">
        <property type="protein sequence ID" value="CAJ1964434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7F9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="248"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1964434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="452" mass="50770" checksum="01041FA6399172BD" modified="2024-05-29" version="1">MAMFLGPWFQGIRAKVLSHFSQSRPNEKATPTKDKMRKPTPLQIVSPPPMGPGGLAAMRQAVHAAAAPMIKQQLCRFTSTLTVTDQLTRTEFIHNQREAIEAKAIKAVCSRFVRAKAMPGGIGDTTKNASRAICPQMTGDTMKNATEAICPQKTLGLKTPATTKPPPRGLYSISNVSIEEKEKNVFARSVEVEAGLKTIAPMHQLVTEAEEHMKTLQHTILLSGNRVMLGAAWMDENNYRQFLCYPEVLFIDATHKTNNEGRPLLLICGRDSAGKAFVVIHVFMPNESQAFYRWIFLQALPAMLGVGNLKRVHLILTDGDASEYNAVDQSIFRYVKNAIRGRCGHHLIEKTFLKHGPKDNEVKNQSNGQAILLEIRRWVRSWIDRTSCHSKKAYELSKALLLQELQTNFVLRPIPNDQNSMYEIRRILSALQPFYTSIQKLIHQINCGQMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7P2</accession>
    <name>A0AAD2G7P2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002196">
        <property type="protein sequence ID" value="CAJ1964682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7P2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="104" mass="12159" checksum="E1C22D9AE723A24D" modified="2024-05-29" version="1">MINGLFGWYSQWIPHIEEKIQRWRTMVMDKPKPGECTKEEEAEQVKAQWEPQDDETLDELKQAIVTGPILKRPNPKRRFYLKTDWSSNAMGAVLLQADTTQKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8N6</accession>
    <name>A0AAD2G8N6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS20348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8N6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="358"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1963831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="609" mass="65915" checksum="13B19D1EAF0EE46F" modified="2024-05-29" version="1">MNIFGRKKSSESIAADSAIQTTTTTDPNTLAKTTGTTNSPTNVNRYQSDIDRANAMRQTHFGTNGYTPPSSGNHNANSSSHNRQTGYVPPSGGNSTSNNNNNNGSNPILQDKVHLALGQLEEAERLQASGKLDSALRLSEEALGTLIGYLRQANQYQNSGISKDVLRSTVEMALSNAEAMKATIAQHQSKPAPPTQIQKPKKSKSKTSSYVPPSSSAPSSQPMKPTRKDSKSKMALGIEKLSLSMSKSQDSQEKKKVKQKTSYDSSDSARSSPANHALHASASSSPPQRPPARSPTSIRINHDDPLVKMVKNDLYVDASQLQNVSWNDIAGLAQAKQSLQEAAILPLIRPDLFTGLRKPQNILLYGPPGTGKTMLVKAVAKESSSILFVCSASSLTSKWHGEGEKLLKTLFQVARAAAPSILFVDEVDALLSARKSEGEHEASRRFKTEFMTQVDGIASSGGGDGGDGNNEAHLLLIACTNCPWDLDAAVLRRFPRRILIDLPDVDTRKALVKHLLQKAGKHSLTRNEIKMLVKRLKGYSGSDISSIASEASFGPLRSLGNLQAIQLANANTIRPISYQDFELALDQSTKSTSQELLDKYDKWKRDQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA53</accession>
    <name>A0AAD2GA53_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA53"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="171" mass="19629" checksum="BA4255CD0850F8FB" modified="2024-05-29" version="1">MCQANDLAQRRHRAAYVAPSADLYPDTASAGAADDDVTTASLIPLLVEVPSHSNYDRPVSPPSSIDWLDLEGALEADKKSRNINLWRVKVMDIVKACKRWFMDIVAVVYMCFLGCFVYDVEVRVVKSNRRRMRERRVIVRNEGARRRNRPVRTTSLLLREDDERTQPYGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAI8</accession>
    <name>A0AAD2GAI8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAI8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="175" mass="19614" checksum="9D1CE4A8C54ACB20" modified="2024-05-29" version="1">MSKSQHKTTDHTNSLEKAKTAINTIKERLQPVVDKVNDHDFGVYSAQAHATVALSIGMLKYMAARLQGKDRGRKADDPLRAELNNMKRILAEVKKKTTEKVKKTDDSTAQKTTEQTKPDSESEKGKSTAPSSNVDSSIAEKKKAEEVKTKKDKKRKSSDFNERGRSKSPKSRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBF1</accession>
    <name>A0AAD2GBF1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002329">
        <property type="protein sequence ID" value="CAJ1967479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBF1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="322" mass="35601" checksum="0A5C496AF7F39C60" modified="2024-05-29" version="1">MTKPNTSADSGFGAPLLADIFEATVTNHLKCPRPVDEPNHLMLGSLCGTTLGVSLDEGRRAFAEALFPVIMSDGLALGQKPLNGDSWKILIFPFMSECPVGFVWPATISYAEFCDSLENRNSEVFGGLLHLLSTQKAAIQNWFDALNANSQVFGVPVVSALPLWDNFPTIDNPNGQSLIGDCKQLAPFQVQQDRFLRNHFSQIVRRGPIAAQSKAFQMARMQYHMFLKRGTLEYPLDQGGGGTLSAECQPFLSQMMRPMDGWNDDGPNWCANFTLDPVEVPSPFHLYPVKDIPKTAKAPPGYKPQRLVRPVEEEPGDLLMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBJ2</accession>
    <name>A0AAD2GBJ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002345">
        <property type="protein sequence ID" value="CAJ1967732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="125" mass="14112" checksum="666D3A4CCA7B4417" modified="2024-05-29" version="1">MFGIPSMTPVMGPFPLEDTFGMGPAACLLRRSLDPGRNKAIIQFATAPRFRSAYSNAYHASKSVEHISSMAYESNKFYTTTCPTYGYWFGRFILGCHKRMGDKVVQDYALSRKIFVELLKHLEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBP1</accession>
    <name>A0AAD2GBP1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBP1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="278" mass="31499" checksum="4AED81CBD3F1702D" modified="2024-05-29" version="1">MMMGGPCCNVSFNEEVKVLRIPSIATLLDVADLKTDLWYSKAEIKAIIKDAKLVVQRFDRGMQRATDNLRGLERGTDAGFYQSQKNKREAYKAVIRERMRQERLGIDDATGLQKAYATVSLQCAQAAVDTAILDSLYAHTKLCPDSNNCFTRRLFTSPASWFGFQKTPPLWQSMNPQLEVSSTSEDSLSGGNMLPVCLNCLEMQGRVDYMFFNNGSNENPAKPNKVVWNIDSLVYNLQKVQKKSIKRYFGADNPWITNPEAYLIDTLFHLDWISNQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDN4</accession>
    <name>A0AAD2GDN4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002509">
        <property type="protein sequence ID" value="CAJ1970395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDN4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="156" mass="17192" checksum="FA4422BABD626AEC" modified="2024-05-29" version="1">MPGGVARVGRYGVTDGRPGVVGVPRCAASLWRRQLRRDSHKWRKVGVVRRSTEVELAELGGVSLEPVQKMLLPYRIGTGPGKRELVGTGARRWVVCQRREVSMDMGDAAGWELAEFEGATGGQVKQRMGADATVHFERAPGREVGVDGQQMHRRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GE50</accession>
    <name>A0AAD2GE50_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002487">
        <property type="protein sequence ID" value="CAJ1970249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GE50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="160" mass="18829" checksum="244B58FA1472EDB7" modified="2024-05-29" version="1">MFDRMFKKIKAKQDAEDLMDEDYQEHEWITANEDMDYEDEYESELDDEETKQMLDELAAELVELGKPDKEEVLFEFDDDTQEDVAVESEEEDGVARAGVRFADTDDNESDTKGIVRSYSDDSVEVGAKRVLRPRHNRSYFSQGVKMRPTERYRREKSRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGR5</accession>
    <name>A0AAD2JGR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS11896</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGR5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="58"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="257"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1949041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38258" checksum="1314F955EEFFF2B7" modified="2024-05-29" version="1">MVFGLFDSHEDDQNNDPSQQQEDRLKLIHRRSSMQKIDEAAARSKEFLESDKTTTSPTAVRNSFIAGWTAGVTGTLAGHPLDSLKVWVQTGIRPAANPLAANANGMLNTVRRYYSGVGGPLVTVGLLQSINFAVYDTTRRFVYFHIDNPQADPHGPEARDYLNQDSYTSVGVAGFAAGSVLSLITSPILMVKTMQQTRGMKFQEALRMTRANPATGFGVHFAVETLNRSVYFCTYEYLKRYFEQQQLQDNDDAKPTASLGGRMISAAAAGINCWAWLYPADALRSRMYAQMAAGAPISTLETAKIMYAENGVRSFYRGFTVTTLRAGPVAAAILPVYDYVLDTLNTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGW1</accession>
    <name>A0AAD2JGW1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS12002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGW1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042042427" evidence="3">
        <location>
            <begin position="26"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1949255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="605" mass="66279" checksum="5592F559EC4A7660" modified="2024-05-29" version="1">MTLSSFLASTLVFLLCVDNVHHVHGLPAEVHPRQLESDTVLAEAFLCDADFNKISSDNVVNKGDLIRICVKTHVRAKVQGISIAKVIDFFLVREFEDAGDMEQILLQGGVVANANDELTCQPGSELCVLESAPMDAFFGRDGTVSAIGSVLLQYDDNDVGTSIPTVTVTTAPTIAPTSLTPPLAPTSAPTTTTSTPQNETETLVPTSTNETETAVTPAQFGNRQLLLDSRVIVETSFTVVTAGSGTGFLSDFREHWDSSPTSIKVLYVFAFLFCFMILFGLGLGLLLWAGFCGNTTELRERLNPLLSREQNNAAPGKETNRDDHTMDESVGAFSPAFARNKEPDHYDDEPETIPKQIGFKRPFASSGGPDMEAPGTDDVAAPGRKPRRPRNSAANKTSRERNSAYKARMARNNYRQTANPNRDLAASFLNNFPRRKVASVRSKTPRSIHERNRPSVGSSNVVDDMPREKTASGIRWLRERDQLQQSTHSTNTTGSRRSVNQQKLQGSSHVSGLAPRRGGIALHGNPIPKSSQRPIPMPSQRPIPKSSQRPTYPKPLMEPIPDIPENFPSTDNDESSRRVHFDVESSPDMNGDDIRHGKDNPRPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHF6</accession>
    <name>A0AAD2JHF6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Mpv17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS12261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHF6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF121">
        <property type="entry name" value="OS09G0315000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042046894" description="Protein Mpv17" evidence="7">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1949765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30798" checksum="0B72E4106C6C688E" modified="2024-05-29" version="1">MVSARKTLALCLNGSLLLQEPSSAFTGPTKTSSHPSLKRSRVGPLHSFEVMEAVGTTHAPIMSTVNSFFQTQPYLAAFLTCSFKASAADMIAQTQEMGNEKAPSSEVSSSGNNEANNNVNISRNLGFLFYGGIYQGMAQNFIFNVIYPSWFGTDESLALVGKEVLVDNLLFAPLLCLPIAYAFKTAFSSEEPLGLDTLKVGLENYVEDVTTKGLLARYWSIWFPANMITFGVIPPHYRVVFVASISFFWIFMLSTISSSSEEESTVKVEEVKAMPVLSMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI95</accession>
    <name>A0AAD2JI95_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001820">
        <property type="protein sequence ID" value="CAJ1953153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI95"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="774" mass="86162" checksum="3B5FCE44BC978D32" modified="2024-05-29" version="1">MSPKCPNRLLPKIQWKNQDKYVDYGKKLNLSQIGATVPATVPATIPAIVPGASASTSGASSVAGSINTPLQLAHTTGNQMMQVPSGMQLMQIPTQGGSTITVPYSMNANGEIAFSGMQLSRQGFSGAQGKHENGKDVYLIPCPAGTTNVGLQANRHYASEDEDLPDLATEADRGLQFIQSRRKERDPFGLYDHVIMDSDCTNTTICNGELMHGLRHAEKELDMHTNVGSRVLDEEGFLGRFPPPVYHNEDGIANVLAMRKMIAAGYRIIMDTDADNAFIVHCDGNRKMRFVNCKGVYVLEQLGANVEPGAKETSVMYRRQSSNLNNQPHFELSSNKQNGYTGLEMTSKMATVRKNKEGFAPRQVKAAMQARSAIWTDSKNSMEPQSIKAIYIEPTKGQRTGHQVLNLNTKKMISQPKVVVLPVTDQVIQRVEAWAATKGITSMKFFDKKRDLETFQDGDQIAGVDDTEQGYLEEAFDQDYEPEDEDECDFNLCGQFDDINDSKREELLADADNDVDDMPELTVRFQGDDDYESDDDSGDDLCGQFDDINDSEREELLEDADNDVDDMPELTVRFCGDDDFESDDDLGDEGNEEEEPIVANFDHHQENVDRGTDDIGSLVTDLEDLQETPEEEIVFEPEEPQVAKVTRSGQTYVQAAMSGLNLSQVPKKPREWPSSRSGSSDNKNKNRAATRPKHRERELKPLKNKLKSGIHTKEGSRSTKDSKAILEAKHNLCFQQIGNEMKADYGEHNTILIARCMMQIKAKFDTGKGLCWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIS9</accession>
    <name>A0AAD2JIS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL17c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">50S ribosomal protein L17, chloroplastic</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">CL17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS14514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIS9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_bL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1953916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="173" mass="19829" checksum="53E4B554F10CD295" modified="2024-05-29" version="1">MKKRIAFRKLNRTPAHKWSMLRNMVSSLIEHERIVTTVAKAKEVRHLADKMVTLAKAQDLHSRRQAAKIVRGDWTVSKLFDVLGPRYQLREGGYTRIMKLSKKRAGDNAPMAVIEYVDRPGEIRAARPPSKLQEQIRMKGIEEAMKEMGIAPPEELVSEEELGNIRQELESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJU4</accession>
    <name>A0AAD2JJU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS16735</name>
        <name evidence="7" type="ORF">CYCCA115_LOCUS22978</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002348">
        <property type="protein sequence ID" value="CAJ1967874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="32"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1957486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1967874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="227" mass="25637" checksum="F6AA594E3D5BE3D9" modified="2024-05-29" version="1">MTTEMTTESDILSQQNSLLELSMQQDGSLRTSKIPFGWKLHTMLEDTEKSDMEDIVSWVNSGRGFKVHDLDAFMEKVVPFYFRQSKWKSFQRQLYFYGYTRASSGAYQHPSFIKGNKTLSLSMRTTKIKSKAAKRMSDNSISSKSSFSSASTCEAIDPMPQIKIPSYNANICNGEVETWTSRIDKVLLNEAESAPPVPTSTNLSDGDRLSTFGGKCFHFVFDYGNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL75</accession>
    <name>A0AAD2JL75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="248"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="452" mass="50396" checksum="B614ADB8AE670E7E" modified="2024-05-29" version="1">MHFFVVTYEFIFCPFSGNGILARSLVNSLVGLGHFVSVWCTKPASSSSTSSSSSFGGDDEDEVMMTIFPHHNGRLQIFTTTVEESKWRCLDENSAWETFVYSKSDEATQTGLRSLFEEHSQHNKMTTDSSPIIPVVIDWHGAHAYQSLPFPPHWKVIYMNFRVYAAGIQDETRHAWLNQMEQRALQTADQVVVLSQHDKELLENLLLEGSGKELQVFYPPLRKDIQELGTLSSSSSTPPLPLLPTSLPVGKRFVTCVVRLSPEKETLRFIPFLNSIRDLMESKGWIPMLVGSPSDKPYAQMVRDQLFHDFPQAMDLVDTFLSPHELCAIFQATAINFHPCSYDAYGMTIVEAAAMGVPSVIADNGQVGASHLIGKDAFVPMDMVVVATIALGGGEEENRDDINSHKSLQHLRTILQDDANLRDIGQRARERALAWNEEAYGSRLVALVSSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL88</accession>
    <name>A0AAD2JL88_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1960007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042042430" evidence="3">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="9596" checksum="1DCB49AF7E69C304" modified="2024-05-29" version="1">MFKSIFVFVALFAVALAQSNVPVAIPVAVPVAVPVMVPVMVPVMTPVAAPVATGKAPKAAKKAKTPTVSAAKGSKLSASSASSKSSRRYLNQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMV3</accession>
    <name>A0AAD2JMV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS20560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Hook C-terminal" evidence="5">
        <location>
            <begin position="208"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="203"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="325"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="486"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1964293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="66222" checksum="3767F7EAAEB13BB9" modified="2024-05-29" version="1">MGDDGGKPNAMLDFLATFPTLSGHPPTDMQELGDGVAIFEALSEIGPDYFDPTTIARHLGDNWALKSSNLRKLVRNLEWYFHEELKKEADFETLNSELGNIARSGDEKGIAHLIELVAAASVTCDLKGMFVGRIMRMQPASQLELKGVIERGMKRISVYDGGNDDIDELEMNFDTPDANEEEDKEDGALFDADHLKDPSAVDREDLETALLETRRELQHQKSQISEIREDGEKAQTKLRALVEDLQDRLAKRQDELITAEEELRTATADLDEAKSKIHDLEEEKAQLDDELDVASAKATQLHKAEATVIAYRKKLEGVGVINQQMTDLEDQAAGYLRQIMDLESEVKKTTTLSRQVDTLQKQLSELQRDKMESSDTQKNSSAEIGELKNLLSAAEKAKKMYQDELKELREQQAAMVDVPEVEGFDRQSEATTTSPADREKTMRLEIENQKLKEQIQAMSQNGDVPVPPTVETASAPVVPPSPTADTSALEKEVAELKNALAKKETENKKIGSDKDKLEAYTKRTLAKFQDKYLVALQECKAKLKEKQDKIEILESRSATEKTAQKREERLLSSTIYELGLAIMQNRLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN02</accession>
    <name>A0AAD2JN02_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002217">
        <property type="protein sequence ID" value="CAJ1965727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN02"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="600" mass="66111" checksum="BC49D960502422E4" modified="2024-05-29" version="1" fragment="single">MVSKAQDMLKIHMEVIRNPGVNLYQGKDQPNKGKGKGKGKGKGKPKDGKKAACYVCGNKDHMSPKCPDRLLPKTQWKNQDQYVDYGKKLNLNQIGATVPATVPAIVPGASASTSGASSVAGSVNTPLRLAGTTGNQMMQVPSGMQLMQIPTQGGGTVTVPYSMNANGEIAFSGMQLSRQGSSGAQVRQGFDAVKSGYFDMSNVFHDAIKGKDENGNVVYLIPCPTGPTNVKLQADWHYASENEDLPDLASEADRGLQFIQSRRKEQDPFGLYDHVIMDSGCTNTTIYNGELMHGLRHAEKELNMHTNLGSRVLDKEGFLGRFAPSVYHDEGGIANVLAMREMIAAGYRITMDTGTDYAFIVHCDGNRKMRFMNCKGVYVLEQLGANVKPGAKESSVMYRRQLSNLNNQPHFKLSSNKQNGYAGLEMTSKMATVRKNKEGFTPRQVKLAMEARSAMHILNAPSTKSLKHAIRSGLIKNCPITEEAINHAKAIFGPNTSTLKGKSTRPTPKKTYNNFFSPPEELYQHNRSITVCIDHMEIENAKFLTCIDTTVRYCSCNPMQNLKTDPVFEALDKIFRHYNKAGFQVKIIKCDRAFIPLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN06</accession>
    <name>A0AAD2JN06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002258">
        <property type="protein sequence ID" value="CAJ1966103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="111"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="181"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="260" mass="31608" checksum="E6D1556254BCB811" modified="2024-05-29" version="1">MNLFHEDNMNYLLEPTPLDTSRMKHVEKVSLFDVSLSGSYLEDLQPLLSLQSTNPKFPKFDFSDYAKFDEKIQPSHWYYFADKVWSEEPYDNQDKAEGRHVNFRSQHLDLWDKRYQQLVQFKAELSHCNVPLNYKTNPCLSNWTKRQRHQYRLKMEGRHTTLTEERQVMLENLGFVWDSHAAAWNERWEQLRDFRLEHGHSRVPKNYPKNQPLAIWVKCQRRQFRLWSQNKRSNITRERVERLKDLDFVFNPRCNIRAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JND3</accession>
    <name>A0AAD2JND3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Polynucleotide adenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS22257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JND3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="5">
        <location>
            <begin position="82"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="4">
        <location>
            <begin position="321"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1966674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54259" checksum="D0126E4552BF0555" modified="2024-05-29" version="1">MTNQDSDESNEDNVLDQDFLSLRNYTNNNDDEDDGGDSNYERESSSSQHEGQSGATYNNGTDLPPWMKESVDYRRTNHLVALHNEIVGFCRLMEPREDEMRLRNEVLDRFTKLAKTVFPKSKVQVFGSQATGLCLPSSDIDIAIQLDPADRTGAPSTDPTTTNDDGDSKNGNKAEEKSDKERKAEEIEAMENWDAPTGTPLHRLAAALRKHWMPELYYLEVIEKTRVPLVKFKHGPTMIAVDVCFDQESGPQAARLMHQYMDALPPLRPLTFVLKYFMASRGLNQPYTGGVGSFLLQMMIVSFLQHRERSVMRNRQPLVYNLGGLLIEFFELYGIDFNYVTTGISVRFDGFYFPKGASDRKEHFWQPNRQSSFAVENPFDITSDVGASSFRMNMVQRSFEIAYKVLLSHVTEPFQPTTSILASILPVSEEMTQRVPKSLEPEVTSADKLSSALQAGRKNKKERNSGGKRPKKRQRRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNE4</accession>
    <name>A0AAD2JNE4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNE4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35399:SF2">
        <property type="entry name" value="DUF839 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35399">
        <property type="entry name" value="SLR8030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="902" mass="98835" checksum="1DBCB0E37EDB51B0" modified="2024-05-29" version="1">MSDMQQEDVSKLTEGSHSSASKWTGLSSFLTPQSWQLNRNSDSINMEHVEEEIEIEYSQTPMNNNSSPWRLFHTAPFTSPLATVPSDTSSSTVPSDEENEDSDDTDFIKAYIASMETFLATNTKARQTISAKDSRRNTNRNARVNALGQIEEDNAPVTPAQVVPQVEFDSNQTKFYVESEISGETGGDSLLAGISVGTEAAASIETVDVSNHDKKKRLLGLGKSPARKVQVLVPQPPREPASHVPAATESMSGTATTHRDDSTKAVVVPMREKASAPKKSSDPLKKKLKTLDEPKKKKKLIQTRTTVNRSLLRKIVLFLLVVIVLAVTISYTSSGSEDSVSQAAANGGEGSGNEAVDNLNPTDGSNGDTTDGDNNASGNDGGDGSDGGDASDGTSGNPSNSDGTSDGNSPTAGNGSSEPNVFTVPTAPPTQTTLATPKEPAKAPKTPEPTRFPTPPPTPYPTPPPTPGPTPPPTRPPTQEPTVTPRPTPRPTTEPSALPTQEPTWKPTTAPTPVPPGITVTYVPGKLTRMENGIRLSQGLKSRIIARTGQRVPLTANEGIRGASTQSNEPFHVRPDGAEVFFDSDTGGWAYLSNSESKKQGEGGVGAIYFDKNGEVVDYKMLLKDTTWNCAGGKTPWDTWVSCEEIRGGSIYQVDPFDRRPPQETTMGQMRGGFYETFAYDVRDSTKPRFFATEDHHRGTLRRFTPNDASWFDPWNMLHSEGELEYMYMTPDDDTNRTGTFRWTTDFETARNNAFLYFQNSEGLDVRDNELYATCKYYKELFIFNLDDFTYTVHSTVSGLFDGMPDQIKRLVHDEDELLYMCEESGSENGIHARNSRGWFFTILESAQINDETTGLAFSPDNKHMYLAYQDTGLIFDVWREDGLPFNGRTLNVRYHENAQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNI1</accession>
    <name>A0AAD2JNI1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1965996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="243" mass="26603" checksum="CCA0EE5306B8566D" modified="2024-05-29" version="1">MSFQDLLQLEAMTDSFSDLSAISDANLISTTKDDITVFVSGQTFFMLPSLFEQVKGLQWYQVGGLYHLDAESDLFEIILQFFLVGSLPSKALVKKRKESLQQLVFQLGSDADELKMCVMQGGGSRKSHSRSPLSLKKAGLSLRSSSSNRKSPVPSSAGSSKKGFKSPFKRKAELSASDFVKLSNALLLDDMDGDSGSETGASTISQNSQKENSSVKSKKKWSLSSKPSTQEVHQSWCESEYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNR8</accession>
    <name>A0AAD2JNR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002227">
        <property type="protein sequence ID" value="CAJ1965844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="476" mass="53821" checksum="6D48976E0BD6B2FB" modified="2024-05-29" version="1">MILVHRYRTLIGYHRRKDWELQIASRLSSTFIHRMDGILSRKMAKVLWGSKHSYKLGPAAIREVNAIIHSLRTEEWKIFIPQMIPRDHHFESFGDASFIGGGAYSTSLDYWFRVVWSKQIVASTKLKPSDASYIHINVLECLVSFLQAVALVITIESSALSAPIHITEVSLDERLAQFPAQCRTHLRSQIRAVMQLESGPTKSTRVLGTIRSHRIHFLRFLRRLNWPQMDLLLESVSHDARTHLLAAFAVDLAVGNTVTGKPIKAATIGNYLRDTATLLENFCGRDPRYTNRADHDLALPIQAVLNECKRHENMPHRVDPYTIEMHTTLVALTATTNAHMDGLHCAMEDWFNLSTYLGFAFANGPYRRLASGGEIAPNGTKHAFTLDDIRLFDSGNRPVSIAEFIQNFDAVARSNVKFSWQKNHDHGEEKLLSSNPRNPSRDALRSLHNIVSRFARIVGLDKTDIPLAVYKGSIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPE0</accession>
    <name>A0AAD2JPE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPE0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43796">
        <property type="entry name" value="CARBOXYNORSPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43796:SF2">
        <property type="entry name" value="CARBOXYNORSPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="411" mass="42889" checksum="4744EF0F1A2D41E0" modified="2024-05-29" version="1">MSASDSSRISFDAIQGKHVLVVGGSGRVGGSVVTQLLQRGAKVTVGGTNLNNLEASRARWSEMFESLDASSIGFSILDRENPDSVSKAIQEKSPDLVVHTAGPFQGKVGTINGVLEAAVNNKVPYVDVCDDYCTARAAKSKYSQIAESGDTPCIVSTGCWPGVSSLMAKSLAQKVLATDKSLKPEDLTVDFSFFTAGSGGAGATLLVATFLILAEEALTVVKGRRTPVPAMVGYEDISFGPIVGTKPVAPLNLLETASIHDVLGVGSVKALFGTAPGFWNQLLGLMAQLPSSVLANEDLMSKLAIFSLPIVRVVDYFAGATNAMRCDVIAPDATTKASAIYAHENLEPCVGECVVAFCSAVLSGKVAPGIWFPEEAISSDQDIVDVLSLASVGAHTTEVEGIVTDKTEVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU89</accession>
    <name>A0AAD2PU89_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001757">
        <property type="protein sequence ID" value="CAJ1948813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU89"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="310" mass="33409" checksum="8E2D581080D26F33" modified="2024-05-29" version="1">MSPKCPDRLLSKTQWENQDYVKKLNLNQIGATVPATVPAIVPGASAFTSGASSVAGSVNTPLRLAGATGNQMMQVPSGMQLMQIPTQGGATVTVPYSMNANGEIAFGGMQLSRQGFSGAQVRQGFDATQARTPQAVKTGYFDTSNVFHVAIKGKDEYGNDVYLIPCPAGTTNVKLQADWHYASADEDLPDLATEADRGLQFFQSRGKKRDPCGLYDHVIMDTGCTNTTICNGELLHGLRHAEKELDMHTNIGSRVLDEEGFLGRFPPPVYQDEDGIANVLAMREMIAAGYRITLDTDADNAFIVHCDGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVM3</accession>
    <name>A0AAD2PVM3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="555" mass="63202" checksum="B195A209BBC0270E" modified="2024-05-29" version="1">MKFHLYLGEAAELLADAADSEQVEVQEQVKLISHECFIYWDNLRQVRLPQGLQVIEQAAFAYCKSLLEVHIPSSVKVLQDMAFVDCSSLTTVWLSDAIQVLEQSLFENCVSLKDVHLPLALTTIKESCFASCKSLRSLRLPHGLQRIGDWAMARCFCLTSLTLPATVDHLGRYCFQQCAQLLSLEFPMGLSFIGDHCFVDCSNLRSMIIPGAFEFAGSYPLLDRSLLKIGFQDYVQGDSYEDETLVRLLNNRFESLPIHDACYHLSQHQHTADFDDDSNSTGSLKHLQDIVKEVYSKTKTDNKWNNLQAWITGVDGFGMNPLHLLCLSGAPNAKALQLLLDEYATATTASADIAKNRHHHHHHEQQEAAHSSMLHDKDIFGGTPLAYLCWNHQANDSQKLCQAVFDSLIVKTRLPQIRLKAWKQVISKKMSYALEHWDDDDDDKDNCDTVTKEHHHNYCDRLELVARVFFALEYHERKESLSLLECWLWKLQLQGNDHLDSSSPSSLARIEQTDHQQEDRQQCRIHCGADVVIPNVLSFLPPLKEGKYLKEFTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWC2</accession>
    <name>A0AAD2PWC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS18407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1959990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="564" mass="63718" checksum="2BFCC308EA6A9226" modified="2024-05-29" version="1">MNNVTITKPKAAKTASTRLCFPQKVYNVLNLCEENHREHIVSWMNDGTAFKVHDLEQFEREMLPKYFNTQKYASFTRALCAHGFDCVRTGRQTGIYSHPKFNRNDPYAPSMIKRVKKANNTKALNKLSNRSNGLSSRDGGRSFVFPSLLNNTQTLMDEDANASGFAQLYQTVRSQIADRTTNALIRLPPGSQYVTSDEQSDDDSTGRQSPYNPIPNSHSSGRIHLAAIAERTDDPNLVTQNFVPTMDSPTRANLIWDEPEQHEQIAHNNCSVFGNNEPSIPLSSELRLPAESQILGDCDIAQDEDDFEPIPWSPEHTPLQNGCEHSHPDQDILLSCWEPRGIQEMTEESNELNSWYDAMPIIPKSRYQALYDFSSPVALPALFHYMDISTFGMCWAMFLIVGHTIQALFTAFGPNTQDLVLSPKISMLKHIFMDIMWMHSLLSAMVLVPEYFGSSSVMLAIAFISTQPPNLATSLKTHYHMNSQKGVPFVHGEWWIADIVRLIFLGYLIAILCICIGHCFTIANLKLIGIFILNLTPLFTCESYRMLLSIPARLEGRHGDKKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWT0</accession>
    <name>A0AAD2PWT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS19671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWT0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1962405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19047" checksum="BFEE86359DF8A775" modified="2024-05-29" version="1">MADSGTVKLVSKEGDVHEVPISVAKMSTLVATSIDDDDDEDDDEVREIPLPNVKDAVLQKVIDYCTHYNKEPMTAIQTPLKSNKIEDMVQPWYSNFVQVEQNLLFELVTAANFMDIKPLLDLTCLAVAVLIKGKQASELRAMFNISNEFTPEEEAQVREENKWAENQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWV0</accession>
    <name>A0AAD2PWV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M6-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775:SF1">
        <property type="entry name" value="PEPTIDASE M6-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042098291" description="Peptidase M6-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M6-like" evidence="3">
        <location>
            <begin position="230"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1962384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="788" mass="85536" checksum="C60869A189F82C64" modified="2024-05-29" version="1">MKFSTVALISLLGSTCFHSASAHVANPRPFRLYEENGDDLGLFRLKGGDINSWFEDLDGYTVCYRDGGSETRRRHLSQERAESVRTGEVVAGKNATSHYTWQYYYCRLHEDGTIGPNLHFPVATTDPNEVSDHLLPPHIHMSLQQAAEICGSYCQKSLKYGGSIPRDSGRRRELRGHRKLGDYAPSKGRVPNLVIPFKFKDHASRQLPSRADLDILMNSMEKNALAPTGGVKKYYHDISNGQLNLDSKVIDWIQLDGKYDERWCSGVDYPDQDKGMGVNMEECLERVLELTDKVVNFSEFETNNDGYIDAITFIHSGYDASVTGMKNHIWSHQGGLDIFTTNEGVKVSLYSVSPALYGSSGTKIGAIATIAHETAHFLGLEDLYDRDDGGVGVGAWSLMALDTGFGDGESYPPAMDPFSKEKLGWGTFNSLSESKNSIVLKPSYTSHQYYKITKGFPDGEYLLLENRQRIGFDAKIPGTGLLIWHIDTAKAKVPPKKEDAPLNDEEGHPGQPGWPQNNRHYMVALLAADGQFSFEKGEDSYGDATDLYGKCMGSDSIGPTTSHPNTNTYQGGSIKATGIKIKNIYQLKNNDMVFDICFGGCAPGEQVPSIECCKDDASWVDSGGDGCDKYEPSWCAEAKDFENDDGVSALTACCVCSGSRFGGPLPDTPGGAAPAADDAPAPVAGGTSTAPATSSCVDNSVWADSGGDKCSDYEVDWCGEDAKEFAVNGISGNTACCVCKGSCVDDTTWRDSEGDGCSSYEADWCGDDAVQFAKGGVHANMACCICKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWX7</accession>
    <name>A0AAD2PWX7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002150">
        <property type="protein sequence ID" value="CAJ1963595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWX7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="229" mass="26916" checksum="0B650339BCF0B70F" modified="2024-05-29" version="1">MLLDLNTKKTVTRPFVTVLLITKQVIKIVEQMAYNKGVCDLSTYHWKNGEIILDGDLLAGVDQDELWDDTYIPCKNEYKRSNENLCIEKIDQDEIEHTKNVEEQTEDRSVASIYERLRRRNDDDNSDQDPNPNEKYQNDEDLNEKIQEIEADIQKDKENVESLNNEEQIEETRETYEENDNLIDRIQDEIKECENQVNDVCKSVANLDDNENENDESDDNWDESSDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PYG5</accession>
    <name>A0AAD2PYG5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002527">
        <property type="protein sequence ID" value="CAJ1970513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PYG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="271" mass="30085" checksum="06C082DDAA91D5E5" modified="2024-05-29" version="1">MVEPLYTAFTCADAKSNSLALLDGHYSLTNLLDPATTTFLSHCRFHKDHSPVHLEVTTSDHVYFWSRNPEDKGSEPHGLHNGHFKAAAQSPVIAYCDALFCNIPLATGFFPSNWQNLMNFAIEKKAGDFQLSKMRTIQFLNSEAQADNKKAGCVAMRYAEEHSLIPDDGQCGSQKRHQAIDLALSKRLVWDLLINQQRAAGWISNDAKSCFDRVLHWVAIIAMLRFGLTWRVLLSMFNMLSSTTHRVQTGFGNPPSVIPFQGCGQGSGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCT7</accession>
    <name>A0AAD2CCT7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000102">
        <property type="protein sequence ID" value="CAJ1929901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCT7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="312" mass="34640" checksum="C6B1766FDF771FA6" modified="2024-05-29" version="1">MPCVEDEAIRRSLHREDQFVANNKAVWNMLYSVCHGTDAWPVIKGYKTTENGRQAYLDLVAHYQGEGQLNKRRDSAYRVLNTTHYNGKKNFSFEKFAARVLGAFEDLKNCGDGMSEHAKVTKFLSMIKEGPQGAGLDAKKARRAQAWTPTEDTAQQTHRLTAISGTRALAAVDGGGRNSNRGRGRGRDRDNGGSDRGGRNRNRNQHGRGGGRGRGGSRDHDGTVWSDDGTTILNNGGYSQDTWSRFSDRDRRVVLQARERANSRLMSERDIAELNSLREQNRERQQSEEPAPSPAPAPSSGNVGSGVRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDL9</accession>
    <name>A0AAD2CDL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hexosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS67</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1891335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDL9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1891335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45666" checksum="69D929AA3080B5D8" modified="2024-05-29" version="1">MNFIENNMEVATAVQQSDQGEVLEAQVVANFPPRPDAVVTLLHQDDFLPGVQTMLYSFRKKFSFHQTYPPEVVVLVTPNVDLEKATNILMPALCTRVMTVEEWWPPSQSIDSQLMKGFGKSNKRVLDNHNPGWTKLRIFGLQQYETILYIDSDCLVLKDVSHLLDLNKVYTESEALVAAAPDVLPPSNFNSGVMVIRPSTQVFQTLQKNAEHLTTFDGSDTGYLNAYYPTWFTDFPPDARLSAGYNAQTELYERTKDPKTGESSFWDAQLSHDLHIIHYSEPIKPWQTESSDETNSLHTLWKSWYQKSKNFLLRDKKERAKQEKERLAKKQKLEQEAAAAREAAAKDPKRAHKLVTKRYKELRAQGMSTHDAMQQARHEILPNDSSQPDAGSQVAAMFGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEE0</accession>
    <name>A0AAD2CEE0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000115">
        <property type="protein sequence ID" value="CAJ1931027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEE0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="129" mass="14842" checksum="0CF997E0E8C6DA2B" modified="2024-05-29" version="1">MTCKCLNFTYPYPFLFRKRPYTNRIGLAFVHLVKEKFDVFQFQNNGFDPKLGYGFILTLADGGAVHIWVWVDDFLIHGSSHEKTTRALAFFLNTAVDCGFLFHPKKLVPPQQVVKYCGLLFDTTDIPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHM3</accession>
    <name>A0AAD2CHM3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000258">
        <property type="protein sequence ID" value="CAJ1933258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1933258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="262" mass="29267" checksum="CC2F689E1CB1AFF4" modified="2024-05-29" version="1">MSLNTTSQRAFSMLRRMRPSGGGAAAAVTTTHSNNGYTRNNNVTPFPTKNDDTRRFLQTTNHDSVKPTMEIAKLMPVGLPEMNNETLVTIAALGHHQARCEALVRHIMSIDGVDYDAATTKFQEIEQSNRAGMAVYPYFIGISGGMLAAFGSLPLVFNLNTAVWFNEFYVTTDIPEPKDLETMLEVGSWTWNWMEPPLGALSFSLLCLQYARAQMENLGLHPYTTQVVNSRADKLAAAFPQYDPFLLRQFSKSAPLFKRTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI82</accession>
    <name>A0AAD2CI82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000069">
        <property type="protein sequence ID" value="CAJ1929135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI82"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="53271" checksum="29B868EE5C68EDEE" modified="2024-05-29" version="1">MATTREEDSKWVTVGPSDAQVDIPRDITHVTLQPETDLIEKYGFYGCEALVEVDAPLTSRLRIIRSQAFYNCIKLKRIAIPKTVNQINSHAFFWCESLTSISLVQTQLKTIGGYAFAYCLSLKEILLPATIKVIETCAFFDCKQLINVEFPEGLEVIMDNAFKMCNSLEIVHIPSTVTKIGQRAFTNCSKIQTVEIALERSLLREINAAAFRGCYELQNIAIPSDTLVQSDTFRLCPQLAENLAGNLPPDYDEAMTEFLKHRFDDLPLHKLCYSISYESQEIIAEKIEHLLLTNDKACWYKEYDALRKTPGHLLALASNCTQDSDFHNGVLTILYSKPIQSLGLEDWRSALRSVIVDYTNTLTREDRIFRIDEIISMFESLELMEATSLLELALWKAKMKSWREDNPNTNDASLDDPELRKECFVQCGSHTIINSILPFVKQNRAPMVPFFSNNGDNDDSISNETAISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJE7</accession>
    <name>A0AAD2CJE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS5146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the COX19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="5">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1936347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="133" mass="15409" checksum="F59F33302C8AF0FF" modified="2024-05-29" version="1">MSSMNFSTSKQYVRPPQRGIFPLDHDGECRPFMESYLECLKVSRDTHHKCRDLSKDYLQCRMDKQLMSEENLDNMGYAANKKVHGAHEYDKAKEKAGFVAGKHIAKKEKWWFQKSNKGWKEKSADESGSPSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJN1</accession>
    <name>A0AAD2CJN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000546">
        <property type="protein sequence ID" value="CAJ1936103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJN1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="164"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="239"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="332" mass="38725" checksum="D1D3599E71EB62A5" modified="2024-05-29" version="1">MICSANNDKFQQERRSYSNMEDSSLLTLMRRPLPPLEAPSSSPSNAPVRPVMSFEIPFDDPRMEPLPLRPQCEDTYDESPRQSIFDSIFWTEDFSGASFKEEMKMSKNHKISLGQQGQVRIADSSRSSEAPFFNQSQFLCKRKRTNETQPVDKEETTARFRPYQEKQWRAQFQKLIEYSMKNGHCCVPHSYKEDPMLARWVKRQRYQYKKFNDNNPTSTMTTRRIEDLESIGFIWHSHASAWQEKVNDLKAFKQRTGHCNVPSHHPENPGLSTWVKCQRRQYKLYISGSSCSDVATHRFQILESLGFVFEPQLSKRGGIVEQDATSSKNRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKJ4</accession>
    <name>A0AAD2CKJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1900467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43619">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE YKTD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43619:SF2">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1900467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="214" mass="24935" checksum="37E9038B7AACC32B" modified="2024-05-29" version="1">MVFDEAIKKFWKESPNGTVVNFAEGLETQRFRLQKDMAEDALWISIDLPEAMAAREKFIEPDDKHLHLDVSVLNAGAWMPLVPKDKPVFFTAQGLFMYLEEEENKYLFQQLADHFPGATLQFDCISKWFSDKATKGDWKLTRHYTTPKMPFGVNKPNVQLLFDSWVPGIQIKQVEMPTDKLDGMLRWIVPLFLSIPYLKRMQPGFFLRVKFPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL95</accession>
    <name>A0AAD2CL95_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000528">
        <property type="protein sequence ID" value="CAJ1935946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL95"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="199" mass="22278" checksum="3DA227EB49880A2B" modified="2024-05-29" version="1">MTELSDPSLPPLSTHCRHRSSSKRMSYSGEIVEGDDEEEVRKRASRLSRVSSLEGGDYQQRPSSFSRRLAYPRFDRGVSPTSLMDAICDPFHPNMMDHQQQQKKQQQYETFGAPPAVRDLMASFSSSSSSSSEDESSVDGSAAAAPGTPSPKRYRQRILPFIKMVDFAVKFQGLYFVTRATPKESYSNVHSTATVLRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLL9</accession>
    <name>A0AAD2CLL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1921255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLL9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1921255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="340" mass="39214" checksum="2919A955B2DCF22F" modified="2024-05-29" version="1">MIRAVLFTGIALLLLTYTTLTLSTLIGTQLQLPTTPLDIDNHTSLHVNHQVREVRNTKIVGFCNYNYRSVGKKWYKRLTRLGYTTHVLVATDLNMKAHLESSQETYRFDVALAEPIPLKLDGKRKTKRDRAELELLFAVRWKYLLSQLEKGIHVLLTDVDNIFSKFLNLKDRVEDFDPSVDIWFAYATKYPNKVFAQQGFTVCGGMSWWRASKPAIEFARLIHESCGIMCDDQRLLNNLLLQANITWDWTPAVLNSRVQDGDERFAGLLTLGLKGESAKTGYKAHIWDRDFAFRGHLQPNECPKDNWISMPIVDAKSRHQNWIAKFDSFDTWDRQCGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN88</accession>
    <name>A0AAD2CN88_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000922">
        <property type="protein sequence ID" value="CAJ1940626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="165" mass="18448" checksum="CDDB31BE5827133D" modified="2024-05-29" version="1">MDVDGSSLSERSAKRTHSASASQSTTPTAQKTDTTVTKQSSKAKQRLQRSLTLEERLDGLRQVNLDGMEGQAILVDLGMAYSFQGQQGGNTTHASIILNHILDMLADNLKNAEETIRLLPLSDSAYKKSKQWIQTEGVSQNEYAQIGDKKRTTQKQMQMTFHYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNI7</accession>
    <name>A0AAD2CNI7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNI7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041971546" evidence="2">
        <location>
            <begin position="26"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="443" mass="48682" checksum="FFF42C01D01FE247" modified="2024-05-29" version="1">MVKQTPKKLLLAAATVASLPALASAGARDYAQLGQPCMQRYDSSAKVYKDISSLWKRNDKCQPGLLSNSTTTSPAESRFALTCFVAPNDTGMDPRSGTMDLEGTCLKSSCVGVNYDNVDILPEDQERVTICHRTENELNPWVRMTVDKQAWSDSNNDCGFTTEDYIVKEHGSPNLVQDQMNKGHITDFTTTQEYWGYWERACPYVRQSPEHTHRCCQGPDCCGDARDDAPQEPESPATATATAQFERKLEGPGCKAPPQEAYTQSIYVTFMGEAGQEGMDLEARIAASGTSITEMQEEIKNIYNTQGRFGQCVFFQRLIESVTFDTIEPIVPAINKEYLLTGFRAKATVTGLCTGCQEHLFLPTDSCRDTEPSSCNTCQIPNSDEGEIIQLAGKDLYPQINSNLGTAGEAAEIIRIEGDVVGEPACDPNQLKYLESTGEVVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNM5</accession>
    <name>A0AAD2CNM5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046172">
        <property type="entry name" value="DUF6174"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19671">
        <property type="entry name" value="DUF6174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042117371" evidence="2">
        <location>
            <begin position="28"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="486" mass="53190" checksum="BB0C960CA6B913E6" modified="2024-05-29" version="1">MQGFHSIFSVLMACCVLLSSNSPLVYAQDAETQNQQAHQPEQNQQKNHLRKRELQSVQQALNDAKAKWASFAINEYIYHIRTEDFFYAVTFACRVTSDQVRDLDSSLEVTSNSTLNLPNLSPPTVNGFFDDIQKAIRSNKNPSIQVTYDATYGYPKIVNLDYGQAAPGFFFLTDTIRATVETMIPVTLEMRRITAARLRFNAYLYDSWDATYQQGQNYRVQVRSKVITSVRDESNRDVTSSFNGNANLRNRVTIANSFTEVRSILDTKKPKTFSVAYHPTDGYITSLSATFASYTNDGGNVIYSIINLQQQGTARPIPPTGLPSASPSTEPPSDPPTPTPSDIPTRTPTPYPSSEPSLADSDRPTKGPTGAPSSEPSIANSDRPTKSPTAAPSVAPSRLPTKSPTTSPSSTPSFNPTKTACVPRFDICTPGVSECCNPSDRCGASSVCRPAISNPKDGRDKLARDRAFTGIPSRNGGRRGLQLRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ38</accession>
    <name>A0AAD2CQ38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008990">
        <property type="term" value="F:rRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01523">
        <property type="entry name" value="16SrRNA_methyltr_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007536">
        <property type="entry name" value="16SrRNA_methylTrfase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36112">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36112:SF1">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04445">
        <property type="entry name" value="SAM_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041928372" evidence="3">
        <location>
            <begin position="19"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="369" mass="40370" checksum="DD8D3C515E6B5D5C" modified="2024-05-29" version="1">MLPSAAIILLSLTSLNSCDSLGGRKSPCTLHESSEPSISAPETNEKQGLGGPRSAYMAIDSDGMFESECQEIASKLSVPLSSKIIDSPDERYTHELSLVPYEFQEVSTFALAIESITVGSEDSSKNAKRRKRPSKKPKSNPHFIDFCPPKNSRAGKRSGQESGTDLLVKATIPKKSIGSTVVWDLTAGFGQDSLILALNGASKVHMIERDPFVFALLEDGLRRLRQLSKVGLEFAQDLEQRLTLGAGDGVDALQQVLLEGDKAIRPDICYLDPMFPPRTKSASVKKPMQILHGLLNTQEEAKESIEERLEEERKLLEYALEAAKCRVVVKRPAKAPLLGGESGDGRKPSYAVEGSVNRWDVYILSNNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ71</accession>
    <name>A0AAD2CQ71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS5314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00317">
        <property type="entry name" value="cyclophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1936682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="186" mass="20153" checksum="B056EAF7C2CF32C9" modified="2024-05-29" version="1">MTIATFTTTMGTFKAELYTEQMPITCGNFIDLSNSGYYDGVHFHRVIPNFMNQFGCPHAKDPNSSRAGTGGPEGGTSFQSCDGKTITRNSGGNIPDEVGQSHQRITNDVGTLSMANTGRPESGGSQFFINVNHNSFLDWFDKSTPSAHPVFGKVVDGLDLVKQISQVPTRNDNPTTPIKMISIRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQY4</accession>
    <name>A0AAD2CQY4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQY4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="312" mass="34521" checksum="E6A4AE3987066107" modified="2024-05-29" version="1">MSAYALPGLFPPIQPSLPKETGNASSSSLNDLGLFGPLHEQDNVASTKSTGVFSSSPYLFSQESSESDDSKGDEPGIHVTEAKVDPVRLVQSVSRPKGHSNKKNQLRRRNSKDRLEESAKDPSNSEACSKDEGGRSMHDEAIEFALAISFNGRKYTAKRTMQRIIQLRDDLITEMDDRRRWLLLRKSKLSRGSAEDCEYIEVEIPEIPFLTGEQDGSGVGAGFVGRGFSMLHAMATSYGPVMERWLRNVLAVVPQDSETLMNFLWEPLAHESPVMDSPTKACVTWATLGSIKELECATDDDSESEDEDEWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR81</accession>
    <name>A0AAD2CR81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome endopeptidase complex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR81"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042238610" description="Proteasome endopeptidase complex" evidence="2">
        <location>
            <begin position="22"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32305" checksum="F62D481266DA95B3" modified="2024-05-29" version="1">MMQLASLLILWGCLMSTSVQAITSDDVSTSPLKQWESAFAASSAQSSCLAMKYNNECVLLLYRSPLSNRWKPYSSSSYAPTQSTELLGLQVRPVESTVVQHAPSWMSFPNAQVLAMTGFAPDVDHLARSIQKHADNHESTYEESMTTHSMTTKLAAVVQKAAQSGGRPFGVQALLVGGDDIDPSRGLCIYSIDPSGSWQSWGKGASIGRYSNKLRKALAEALSSSLSATTLQETLSQLIGCWVETRRAENLSASEEEDLEVLVLQRNPKTGHSGLFIVDNDHVKNIFTDLSKTTPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRZ2</accession>
    <name>A0AAD2CRZ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000358">
        <property type="protein sequence ID" value="CAJ1934686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="233" mass="26535" checksum="112CA36F4B85A1D4" modified="2024-05-29" version="1">MKGTKNDNDWRFYHDALTLMTSADLIDYMKAKAIYHRWILPPGQGLFEDDTALRNFRGRPPGDSPELMPWDNNLNQDAHVSVERHVGITSVYEKGDPRKFSKSTPNEGARAYKRVLHPTEGVAPTPKRIVQDCMLWLQALEEIRKSKGTLNDFAKRRGTRGEFSAEERAEMIRTGSRQRGGRREKGSGFRKCLVLHHDAKPAAKIKIEEASKTCEQQRLPGVDSETQVPIQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSY3</accession>
    <name>A0AAD2CSY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001324">
        <property type="protein sequence ID" value="CAJ1945046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSY3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041944253" evidence="1">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="176" mass="18877" checksum="B8FB6137F12E6C72" modified="2024-05-29" version="1">MKSYLSLFLALVFSAAVSAYETSDFTEQVTLIEEHDQNERHLCSPSVRPIKSNFGVGEQIVAIVTVCGGGVEWMGMYSPSAGVFDNAVNWQYTCGGQTCAVPMMANTYAYGFGPWSGMWPLGGTYKFQYHSTAGSVSSATFTVGGNSGNAVPPATGSRAPRYLRAPEEEVDFAPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTM4</accession>
    <name>A0AAD2CTM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTM4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="334" mass="37911" checksum="D981B97FF4D68634" modified="2024-05-29" version="1">MMIIQFQNSLSAFHQISRAKHSLAWSLSVLIFSLLIATSSAGRSFQSSSDSASYITTIPHPALQFSEEEHASLDRRLGKGLVLRNDAKDNKLRPPSSSSSAAAAAVDIQPTQYDDRKSEWESRYTSLKSLRKVFGGNRNRLWGDLDPGSARRLYRFLMPRVLMELVKSGAQPEELAPLAYKARVAAKLYARERSTVPARLAATVYDGIRQFKRYGRFQAHGMTYEQIWDKYQQVVMNDSACRGDYDGLLTEKDLKSKISLKILERSCSTNENIDRKVLPPADSPPSGFLLRVSETLETDVRKLLDTVSQYRKRRRKSFGESGQNERRDMRDISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTV0</accession>
    <name>A0AAD2CTV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein MEAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS9496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001369">
        <property type="protein sequence ID" value="CAJ1945350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTV0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1945350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33284" checksum="D4535726BDD9DE0F" modified="2024-05-29" version="1">MDYRHRPSGEKLPLFLLKKWRKRNQGADVSSASSIAGDTNSQSLKASCGSQADRLFSIGEIENRLRKTAAAVSNLQKQIYRGEELYYEDTMPHRNICKGGLEGFVDTKDVVSGDSGLTRGLHQSIRKVPGDVRWFSESSVSKEEMHKRSLDIVHTASAKKPMIDASDGDLNSSDRKHSQNTIHLNDVNSNPSRTTKVNVESIDTKRKRNDTDEHGHKIPPARRSKTVELKNAQSNVAAKMNEDYSDGNSELVLPKDIDSEKTSDPHSRKGSTTALVKKDESKKVDSQRRRRSRRGANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CW60</accession>
    <name>A0AAD2CW60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxisomal membrane protein MPV17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS10663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001710">
        <property type="protein sequence ID" value="CAJ1946522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CW60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1946522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33209" checksum="0537B5F2817B318C" modified="2024-05-29" version="1">MFFRKHPVYNVLLTVIICNSVLTTALATNSRIGLARRSWTFHTKRATSVPRTFESNNAREYRLKQGKNPIDKRHVVKSVTGATLGFLLIKNRFVFEYALNLYRSSLSNSPLQTKVLTGATLSLLGDWAAQIREGNESTTYDMKRGLSFAAFDSTYRMFQHVAIPVIVRLGQGNFLLWLVTIAPFVNPGPKASSFFAAMERTLIYQFVLIPLAYYPVFFTFTGLMQGLSLSETFARAKRTFFPCWIKNVSFWIPTQLVMFGLVDEKWQVPFVCLVGVLWSSILSITAGKARVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWR8</accession>
    <name>A0AAD2CWR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10134</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10137</name>
        <name evidence="5" type="ORF">CYCCA115_LOCUS10139</name>
        <name evidence="6" type="ORF">CYCCA115_LOCUS10142</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042440655" evidence="2">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1945997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1946000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="112" mass="10789" checksum="51B16D8A2096A1F3" modified="2024-05-29" version="1">MKSFSIIIALFAVAAKADNRLLQTAAPVAVPVAVVPVAVPVAAAGSSSGSSVKSASSSKSSSRRKLQTAAPVAVPVAVVPVAVVPVAAAGSSSSSGSSVKSASSSKSSRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CX86</accession>
    <name>A0AAD2CX86_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001551">
        <property type="protein sequence ID" value="CAJ1945861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CX86"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="284" mass="31091" checksum="5B59F0FAF5E5ACEF" modified="2024-05-29" version="1" fragment="single">MDLENNLPSPLFIMVLPGEMEGTYLFISRLKYAALATNVLKGLVLFFTHHLGESTTTRSNRVLGKWFPKSLIHTTRRKELVWCLETLRARPADQTQQGVDEAIDFLDGFGSDPLDVGEAKLEFDMDMADAKDIDDGATVAGAMDELLEKDSQLEAAITEIEFKDNLLSEQNSALEAERLQSEQLARELAAMRLLQQPSASRTDQPTQLDDSGPSNKLPTEEDIPLPEKPHSPSTPARSNNPGPLTSPLPGSPSPPGPKTMLPPQNAATRPKSLVESVTPDQAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBJ9</accession>
    <name>A0AAD2FBJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1893794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBJ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1893794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36552" checksum="355294E5081561CB" modified="2024-05-29" version="1">MTSTIQSQSNNSIKVGASPKLSTLAKERPDFATNSLKEKLFGDVVIGASVTLAIAPILTIIDKAVVQSASGTHTLARSTLESMQGMLTNPIKTVKSPAFLLVWGVYAGTYSTANCLKTLVEHQSYKEEARNSGKSSTAELGKVGIFLGTTCANSGLAMLKDRTYAQLYGSNPTKSIIPRWTYAMWIARDLSVIGSSFILPDIVYPKLVDAYGFDEKTAKSFCQIALPVGAQFVASPLHYIGLDLYNRNLGSSVSWRESMIDRSKSLYRGILPVTIARIARIAPGYGFAGVFNTQLRDDWREYLLEREVKMMMDDSTNSTASRLVALVHNDPKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE18</accession>
    <name>A0AAD2FE18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000355">
        <property type="protein sequence ID" value="CAJ1934653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE18"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1934653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="263" mass="30163" checksum="8AAB6E87F0470D4D" modified="2024-05-29" version="1">MAQNKILYSAKLDENMRRSAYFETNKRTVKSNIMLKFVTKAMDIKLRGEADFTTTLEDPIELLKRIERFMKKSADAEYDFLDFWEANQKFFAMKQGTTENLMHFKERFLRQAEVLQDLYGVAWFQDFAVKMKAYAAIANTDTAAQNKFKDVVFEAVLATGFLCNSNQTRTAPLMLDLQTNYCREVDYYPKTVSKAQDMLRIQMEVSKTPGVNLYQGKDQPNKGKGKGKGKGKPKDGKKAACYVCGNKDHMSPKCPDRLLPKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FER8</accession>
    <name>A0AAD2FER8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000269">
        <property type="protein sequence ID" value="CAJ1933438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FER8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1933438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="152" mass="16598" checksum="3557A115A7BAD3E7" modified="2024-05-29" version="1">MPGPKLNTLSIDRPSLLTLNPDVAEDFDKAMIPDELLDELKSNSSAEKVAMVHIPDFGFLYVATNGQVHQFDPNLLEVVSQDFQIQTQPKHKDDKGSAVDIVLELDEAGVIKPGTNVLFRFGPKSAESIAQAKTVASQLQGLLGCRDIQLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FES0</accession>
    <name>A0AAD2FES0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000460">
        <property type="protein sequence ID" value="CAJ1935376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FES0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="209" mass="23606" checksum="901DD23BCB7C0A29" modified="2024-05-29" version="1">MSKSQNSMLVKSLNALVVTHSILVEDVDVDAEVTVIVKPLPIHPIQAIKMKELRIKDIAILQDLKATIKDDLLEPVLKPKDALGNETIKQIDLRNPQNHHYAESHYNQDGSQAEGSVPAGTYYNDQEAECFVPVGTVPKVGQGGMPSAEEQHDQYFVQGQFVQPREQQEMYPPPEDSYPPNDLYPPTDDQGYYPYNDASEHYHYYDEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF23</accession>
    <name>A0AAD2FF23_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FF23"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="144" mass="16540" checksum="9A07F1F320163296" modified="2024-05-29" version="1">MYAKKRPPTPVVAKISSWSVVQHCTAIQVGLASITFGIAQVATWGYVFPALIAMFVPFRIHVVSRFFSKEDLEYLDPVEDSDEDYSDEQRELHKVDRDVDKAEVIHGFSELRMKDVDHNASEYYDHHPDVAETVLRNRQRSITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFJ0</accession>
    <name>A0AAD2FFJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000424">
        <property type="protein sequence ID" value="CAJ1934952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFJ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="165" mass="17586" checksum="6570EE90D8C604A2" modified="2024-05-29" version="1">MPYATVEETVTQTRRVRICARCHRQIGSNADLKNLSRAGSLIGSLGTSYGASVMAGAVLGPVGMIGGAIAGSFAGAHAGAKVGTKASEMAEDNKSQPYCPECQAIITKEEQARGVGRTTGESGGENNAMEFLKRVSGSIRDTVEQQKQRFQGNEKNQKNEYNDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHE8</accession>
    <name>A0AAD2FHE8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000189">
        <property type="protein sequence ID" value="CAJ1931877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="374" mass="42871" checksum="B77C75A282E0F81B" modified="2024-05-29" version="1">MPEYPSGSEAEDTRCTDQDIDFLSYNLTQKRNWLLHRKISGIKKDSPCNLVEGIFDAITSSEDIPPIVEDLFLEANLCQVKDVVIGWHACISQIMSITENPTDTAAEIGRERKGPNPKVENNLGLNYPDLVREHGPLRPLSELDFKGEALIQLLEKKFSSGTREENWAYNAYYKDKLYRNVLRDAKQSFLSSINEELSSSEPATLKILQAIDHKIKEGATKGGKTRIEDEMICNTNSNFVRYKDIETAHRHLSTRNNLITGIVVENARYFVLVGLNWEEERYYQIEPDMYHLSLCGADYFTWRICSDNEVKNNLEKIRVPKSTHYFLMLPLLDDISNKGDRAIGCEMRRTDTNVYDCKRSVSSKDKSAAYESCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHK5</accession>
    <name>A0AAD2FHK5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PS II complex 12 kDa extrinsic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHK5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042214952" description="PS II complex 12 kDa extrinsic protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1941153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9863" checksum="2F90B2E9A1F59A2F" modified="2024-05-29" version="1">MFSTRSPFASLLLVAVSFMMVEQGQALISVDTSVRTVGTPKLSGQGNAFQRPEKVNPDTKQPQETFDTDAYRQAMTELVYQRSIQRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHN0</accession>
    <name>A0AAD2FHN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS2888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHN0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042114242" description="Cytochrome b5 heme-binding domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="793"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="828"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="860"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="921"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1932541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113772" checksum="5EA4DCC1DF9D726B" modified="2024-05-29" version="1">MSCQVWALLCWPVLLLLPTIAVSIELSNIPIKDHKYEYNGYGNNIENPTWGAVDGPRVRYLPDEDGFFQRPGVPRSEDNGGLPSARRIMEELFRFPALKEKKASTSTNDFKLIFGMTMSSDSLTAAGTNESEPFDLTGDGNFSDGVFCPVTGQFESARDYDKSFPRYNHQLVVGKKDNEPVRATTNSGTAFLDLGCIYGNSVEENEKIRNQDDPKLFDLVNGTNGLLPRQPYLRSCFGAVPASYALQVVWMRLHNHVAEIIANENAGLNDEQVFQAARNYVIATYQKIALTKYVPALLGDSMGRYPGYNSTIDPSIDEYFAGVTYRYGHSEQPNVIRLADEDFLPTSQDPILMRDAYQKNPQKIVENAGGIEKFIRGAIITPTKPFDYAFEDDLNFYSKATSMVDVQRSRDVGIPPYNQAREKFGLKRYATIRELVEASGYYNEDLVSVMENLYGNDIEKVDSYVGTLFEKPSNADGLFGPSLTASTRDQINRIRTGDRFWYEKEFNATEIAALPSMTDVIKLVCTGMDKFPETFFRVYGSGNEEDATNGEDESCIGRQSQVGLLGGEVVVKWTIDQSNELEDEMKSSIELTLTANVKMEGAGYLGIGWRSRKMAGADIWICTVDPDVFGEVPRSANCDESQTSPPMFSCCLASGANVRPECRNADDPSFYELDVVNWCLSEEESSVTINAQICNDGTVTDDCFDISSNPDGTMDMIVSFNPNDQNKPHGFLRRTSTVVDLKAGILTAAEAGVASAGLIAYHGITMLAFWMLGAPVGIYVVRYMKTKSWRLAVHISIMGAVGGLTIPIIVGIESAVGASSDKTQEHSFIGLILTFLILPMFLAGRIRYSQLQGFSVSRRVALWAYVFHKIFGYAILIFAWWNCYTGLVRISPADSFFQLVVLSSYSFGYDVPIFGVFKNNIFWPYLSIVVLIFAMSEIRKRVLNHRVHASQLLVATKTIWDDGNVFAGTSEVIQEMERGKFLELVRLGTPLCIIDGRVLDLTGFLEHHPGGSDMLEGVAGTDISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FI24</accession>
    <name>A0AAD2FI24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS7182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000946">
        <property type="protein sequence ID" value="CAJ1940711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FI24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF27">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1940711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="353" mass="40309" checksum="54C81FCF8B079BE8" modified="2024-05-29" version="1">MRVRRRFAREKGSEDGRSWKSALTVCSQISGGLLLIAVAAVNMPPSFLSIPLASRNLTSISTTVTKSTSQTSDCCSLARQDTFGLFDDITDTMWKRIRQRTQASSWYWDPKNPVNNVQDPGWWNSHNMIPNFACPHVEKLGGAGNEGTKFVCNPRRLVTEEKPSCLIYSVGCAGDFKFEDEIFKLHKKACEIHVFDPANWERKGDAENKNIHYHAWGFKSTYDEESKSVVWPKGRGGGFKTIPETLKELGHENRTIDIFKIDCEGCEWSTHKDWISVGFRQILVEMHGVPAPEGTPKARWYQKPMDIHNDYYKDYMDNGYALFNHDPNGELGLELSFIKLDKPFWETPSQEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIZ2</accession>
    <name>A0AAD2FIZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calmodulin-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32547" checksum="6A0C5B9BAD296E46" modified="2024-05-29" version="1">MTLPAPEGDDDDFWKIALEEEPTSNREKNGAWGDDDDSNGDDTIDGSKPVAYRLPTTQVTLHLESLAASNGIWSPLGADAWYASALLASMVLTNKIPMLPSTKTVLELGSGAVGLSGLACAVAMARKENMDDHHRIILSDNDPPVLERLKLNAERNLDAILSSASTPDALLDIQVQHLDWNEECDESSPFRNSIDLVIGSELVYTQETAEACSKLLKQLLLNNNQRVDIWVVQVTDRYGWLDVVVPRLKSLQHVSVVSVPISSDTHELAASMIPTGGILDRYAYGAFHIQRQTSGLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJX5</accession>
    <name>A0AAD2FJX5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS5227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJX5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041919354" evidence="3">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1936509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="219" mass="23516" checksum="006E7D47701E3409" modified="2024-05-29" version="1">MKFSKSLLAVVALASAPGVSAFAPASNGQAKTTSLNMINEESMKKAATTFAAAAFLMSNVAAAAPAFAVDDMDFGSTQVIAARSGGRAGGRSSARAPSRAPSRSAPSRSTTVINRSTYIAPPVYSSPVYVAPYNPMPGLGLSFGLNAMNQIGNDMRDYRQEGEIRDTRSELMRSQAREAEMEARLRQLEAQQQGQLSAQQQQQLMMQMQQQQMLQQQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKK8</accession>
    <name>A0AAD2FKK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="200" mass="21592" checksum="E9DE09B429D2C0A9" modified="2024-05-29" version="1">MFVNYDIWLNKGQGRGTEMTKTMHIIFSCLLHRSAFQARQGGRVEFAVHNTGQQMSGVALNNCCNTSRQCKKALADAIASSPDVSTFHSQISACKSAMLQSVSFTPDSNTKSGTNGSGIDKGAARATVSSGSFVEDLKQCNGPSCGRYVSADEIKYCPCRKVSYCSPACQRGKNEEFCLKDVSSVSILLNIWISSTLEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL40</accession>
    <name>A0AAD2FL40_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="197" mass="21915" checksum="5E511F35A2B29785" modified="2024-05-29" version="1">MTTLVYKDNIVEKIGGQSQFDFVIMTYCESIREDPRLGGFFAHLDLDGLILLQKEWLDAALIENSPEETDTIIGRLAVKHKILWEKGMNETHFEQLKTHFIMALRDCWAGEELIQAAGKHFNNLLLLFLQSDKFAGKAAAAAAAVASPVQQRSTWTVRTLDQAGANKNGVASPVQQWSTRTVRTLDQAGANKNGVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLV4</accession>
    <name>A0AAD2FLV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLV4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="69251" checksum="451DA1464E696191" modified="2024-05-29" version="1">MTTLVQVLTSKASVEKNLKMPTSISDQKPSSSLKSHDSGDSATYHHQSEISSQMAQHGNDSHTTSNSTKNISQLSESIQRLDDLLIEETGELIQAAAPQTILNRDSIGKDEWDNYEGGFPLEDDAVSYNIPHSAAPESLHMVLNGGSSFNSIEGSARSEIAESVTTVSLSSRGSTPSNSLPRPLLYSAIGSLENPNAASLGSYAKKLSRVDTTGLLPPASAIAPSAVASIANKSKRSSSSNGLKNGSSRQTSSGSNGGKRSNRGDGTLSNDSQWEKQNQAAQATGTNAVDSEGNAVNSLRNIVQAKSSLRSPQSQKKKKKEKKKRVSYDLKSKKQVEMFRPSCDAYTPRIEKKKIKYKAAENRTPVQTMATTMGTLQRPNFRDALRRVAMIIHQHIVKIERRFESNDARLGSRALFTSAMKDAFSEETFCTPKYKCTMVRIPMARPGMVFGLRKIKTKYMIPSEKEIYEFAHQLFKSVQLSSECSIVCLIYVERLMEAAKVPLMACTWRPIFMCGLLLASKVWQDLSSWNIEFSCVYPQYSLDAINKLEVNFLRNIKWDLYISSSLYAKYYFALRSLVEKVDFRQRYNRMVGRVDSVAQAEALKIQERSEAVKEEALSHLSRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLX2</accession>
    <name>A0AAD2FLX2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLX2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="59"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="415" mass="46667" checksum="DADA6C98D2F70D53" modified="2024-05-29" version="1">MKEPWSKRHKHEFKGTKFSLSNSFAQPLSQPELVEFIVQQDDSSSCHNDLLEMYQNHDLEYVPNGGSLDLRQDIANVVYNQDKNEDQEPMTADNVLVFPGAQVALQTAALAFARDCHSIVFTPGYQSTVESPDWAKTSQGTTQIPRSPENNWQVDPEKLKEAMQPNTKFLILNEPHNPSGIIMSRELQAQVIEICREHDIVILCDEVYRLLEHDHDDTDGSKTIHTTSSSSSSLRIPSMANAYEKGISAVTMSKPWGGCGISIGWLVCRDRSMIQTLVDVQYFGTACVSRVSEIQGRMVLAASSAILKDRMTTIRHNKALLQEFIEVKYAKWFSWNRPNAGAIAFVKFLGPWTSNQFGDELAKAGISIKPAYCFADTIPPEIQQYFRVGFGERRMPLALEALGEFVEKHQDSWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMB6</accession>
    <name>A0AAD2FMB6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001363">
        <property type="protein sequence ID" value="CAJ1945340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="352" mass="39282" checksum="D652CF39E16C2978" modified="2024-05-29" version="1">MQLSRQGFSGAQVRQGFDATQARTPQAVKTGYFDMSNVFHDAIKGKDENGNDVYLLPCPAGMTNVKLQANWHYASEDEDLPDRGLHGYTNTTICNGELMHGLRHAAKELDMHNNVGSRVLDEEGFLGRFPPPVYHDEDGIANVLAMREMIAAGYRITMDTDADNAFIVHCDGNQKMRFVNRKGVYVLEQIGANVEPGAKETSAMYRRQLSNLNNQPHFKLSSNKQNGYAGLEMTSKMATVQKNKEGFTPRQVKAAMEARSAMHILNAPSTKSLKYVIHAKAIFGPVASTLKGKSTRPTPKKRYNDFFSPPEELYHTIDLLPSVLITWRSRMLSFSPALIPLCVIAHVFLCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMC2</accession>
    <name>A0AAD2FMC2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001391">
        <property type="protein sequence ID" value="CAJ1945386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="94" mass="11458" checksum="98DBF4BF2B594B5A" modified="2024-05-29" version="1">MSAATLETIWRKRKDERYKFDMEDMLELIGRKKGEAKKQKYRQQCRDASALSLHPEDEVILAYLKEKQERKIKELFGHEYKLEREVCPKRFHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPC6</accession>
    <name>A0AAD2FPC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS11461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001741">
        <property type="protein sequence ID" value="CAJ1948109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="283"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1948109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="573" mass="65490" checksum="8BAEB17F859EDE10" modified="2024-05-29" version="1">MLGVENLKRVHLMLTDGDASEYNAVDQTIFRYVKNAICGRCGHHLIEKTFLKHGPKDSKVKNPSNGQAILLELRRWVRSWIDGTSCRSKKEFELSKALLLQELQTNQVLRRFVGDKAAEKCVRWILNHILTLDDQQFAFHCKQKVRCLHEYTTNATEGMNYAAKHSAMAAQPQNNMKTLASNMSAHMDIQNHDREYTQMRLSNSTPLYVSAGCTVHNTECIQKLVPIATSVIIEQMDEALDKYTIVQLSSKAFFLICAGPPSTLVRCPPGVKGRPKFRTAHKLDVKACTNDTSRVVLTCSCGFGHQYGIPCRHLIALEHHYDINDFACRWRSDYAYYAFKQGYEEITHNFGELQKKEHFGIVVKTQSLLKSITSPDQTTMYPRIFAKASCCKSTIEDLMDIYLSPIPHCWNYTLNEYPDTGTFSESPSQTNAYHTVETCSPSDYGNSDFAQDEESDDEEGDRTTTLAFNMNQLCSQQPKEQCQKKRAYNFQKFKDIDRNCMSQDDVNFVTSKLEAIDQELFERKALAMKTSQKRAFVGATGRDMVSFALNTETCKKSTQDTYHRKRIKRKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ05</accession>
    <name>A0AAD2FQ05_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001745">
        <property type="protein sequence ID" value="CAJ1948197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="174" mass="19517" checksum="7D1FDD94E3D958A0" modified="2024-05-29" version="1">MQNYASAKLNKTATEGTIFELFVYIPRRQAPHVQRLRRATAPVIQRKREPLRQHAAANNLQIGPIAEHHLATFNVRAPKGTELAIPTDATTRQAQALDRDQARLQNEDAQALADSNSVYRPVEIELFGGTKAMICMNIVLLRQALSLPNHKSFHQGIYNEYTHPVLPDGADMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQF4</accession>
    <name>A0AAD2FQF4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQF4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="140" mass="15813" checksum="0794D173C59FE4E4" modified="2024-05-29" version="1">MQLKNHPFLYVSLTLNALVVFPLTILLLIVKPERMVEVYGPDSEARRILASIYFAIGVASVAAMFRRGDNMINMAFPIFYLQIIYKIMTAFTVGFPNPVVISNVAISAFHMMTMFLVVQQQKANQEGSVEEEKEHPQEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQR9</accession>
    <name>A0AAD2FQR9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="128" mass="13508" checksum="001978CA0124695B" modified="2024-05-29" version="1">MVLPLAAAAARRRVGGVISSQVQRRTMAGGPAKEWEGIDKVVRGVFPGDHQLALAIMGGYTGLFLIFKMKSAMSGTKEEEKPVVVSSGADTGAGIPAIGTPEFDNFLDSEAFVKLLDSEEQLTKALAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRI1</accession>
    <name>A0AAD2FRI1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS12627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="351"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="719"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1950534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1062" mass="116115" checksum="47DDF35CDEC82DC9" modified="2024-05-29" version="1">MTNVMQATNPFDDTFDSGPVDSSLRVNSSNNNNNPFDYDPSAGINPFASTDSAGEDTTTLDDNLDVPSGAPVEASWQYLGDLPYRRVPIYNNVRWCDEGNGNSDVLNYGLSAFPRAALQRHPEMLNPKELRELLSTSTVTKVVGCPHGGPIASVTLPIVGQTAWFSQTEIRIMTSAGRQLARIDFPLPEMLDRGKYSPSDIAEVGFTDRTTLVILLRDSLCLTYDLTGEPLLPPFHLLPKSGTEGQGFELKHATVFEGGAAVLSIAKQSAMVEFLDEHDDPSYFSSAHAGARKIFPDTTISDSLGGKGDSIASFCGLVTTLPTAAFASEYFYSYATIAVLPRTRTASRHPEIFLSTTDNSVVVADAATTELKDLDCRSQISSPIVAMTFAPNGRFLACFTEASMLTVISTTFETKVLDFDTSEGSRLPPLEMTWCGEDSVVLHWKNLGVLMVGPYGDWLRFPYENQGNLYLIPEMDCCRVVTDVAVELLQRVPPATALLLRIGSIEPAAMLLDATDAFENGSPASDEAAKSITDSGMLLEAIEGCIDAAVREFDITTQQRLLRAASYGMHFSFKDGSREKRAIMGGKPEEGQDEMALPSPLTSKFVESARKLRVLNAVRNPSVGFVMTSSQYDSITPIGVVARLIATNRSALASSISKYLSLPKAVQLFARASKAAAFVAGHKQLSDSDAAQGAMQIVHEAIPSQPSKSLSSSVIRGGYATVAMAANKAGRPGVANLLLMLETSVADKVPALISTGSYADAVAVATSASDADLVFHTIMAYQKYCYMSTQDTGRANQAFMSTVTTKFSKEAFHTLRRYMSTLPDVKEALNLQLRAQKFTDAGVTMARRALDKRKDTRERLSILAESSRVFGMGKENAFYKTCTDDYLELLKDQEVLRTKYSSPDVAPESSSVAATIASVLHYAAINEREKHRLLTDADKIAKKFRIPEKLLWHTKVRAFAETGLWGNLRTLADSRAKPPIGFKPFARAAIRGNQSSSEKMRYIERVSDPEERYGLFCEALMWKRALEEAFKMKDEHRIMNVKGSCNSPEYQMMADQLLARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS97</accession>
    <name>A0AAD2FS97_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS97"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="549" mass="62274" checksum="3D9DE432DF3296D9" modified="2024-05-29" version="1">MPRRKNKKFKRQKRHNHQNDECLFETSIEEDLRRQRQRQIERERDREMMKEFEEDRMDETDTSFVENVETRRQDIVLRGMSVAPLIDIAQLPARSLLSVHNESPLLSRIQRNRIQNLWHSRYLLSQMHVHSKASLLYTRKVKWRNHSLPDGTSAPVDLTCKSNLHSAARTMDVVTFDEGQLPTIATTVQGGFGIFTAAYGRQERFNTLRGLPVHSLRMHEKSGWCGTVVLSDDRYALYKFQCYPLPDATSLFEVMLQEPVTDFVFGTDLVLFACPRYYGKATLSPTFLTLEDGREGELRCLNIQNFPHSDALRVEMTCAKEKFIAFGHRNGQVSLLDLRQSQSCCTILQHLPIDSTSEIFGSATDLKFLSNHQLLVKRSFGTTQLHDLRQISSRLEQDSSKMRRRATSVVHHLQVPSDGILSTASSRCNGMVVDPTCQQTLLSPYIDSDRNATLGFWSLKTGTFAGQKILAKNPERDPIFVEMCPTTTASFLNRGEMKHGLSNPSDFGVWLKCGRFSKSRAQGGKAGSLHHLSLPGALADTPSVCSYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUJ4</accession>
    <name>A0AAD2FUJ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001841">
        <property type="protein sequence ID" value="CAJ1953797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="57877" checksum="4560EA337E2D5E45" modified="2024-05-29" version="1" fragment="single">EFPTPSAHQWGGCSATLLNKVAHRAKSGRKDETGLGRFSWIKIRGRDIRQQESQTDGPPAGPLDLVVVSAYCPNKEGTNAGSVWNYQQNYWLSKGVTVDPRDKLTLDLVDLIKKWKAEGCEILLGLDANEDVSYNSPSSFRQEMRSEGLTEAILLRHQGPYPATTQSRMTDTPIDGIFVTNEVRVTAGGYLDFQQYFKSDHRGLWIDIDLEATLGAPPVTSLSFQPRRLTLADGRSVDRYIKAAEAGYRHFRLPQRLTQLAEDISVQDGYLTANQQARFNTIHRQAYEIRRRAERNCRKLTMGKVHWSPQMQQKWDRLHLYQLLILGHKQVRTSSRKVRRLLKKTGLSDAWKLSESDLQAKGHLEYQAYKEVKRERAQQWRLEYLENRSAAVQKAKKSNIKARTRRTRVQRMAQKEETRRRRKAQGKGFSGGLQQIKVAQVAPDGTSHWVTCQSKRLVEEGCMQENRLRYDQTRYPYSTPPMTEPLYSDFNGPIVAWRSLSLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVK9</accession>
    <name>A0AAD2FVK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVK9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="172" mass="18744" checksum="8AF3D309DBC80D62" modified="2024-05-29" version="1">MTQTATAATTTTANDAAMEKKAHKALFRSQVMSGTTPIQLKAKAIRSKMILSNAPGAGGKVAATSNGQKLPSLFKETNFQYLGDTVIIWNLKEYLDHPKWKEDALRRSLKRRQREESLAMSSASNSKSCISLQGGGGLNSKNRKKRFRAVVEALYQKSLAENKTAAIPGKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWA6</accession>
    <name>A0AAD2FWA6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="361" mass="40664" checksum="A404BCD35E788677" modified="2024-05-29" version="1">MAMKLRGAIQKLTEDPELKDISLIAASDVDLEIDSFLVCLRKSRIQKVIVWTDFLSCLEEDKMLEFLQLLQHLSHLQELIFKSSSRFHVEIIPGEGLLSIREISCLKRLVFEDMQVTALQTGFIQSLSDALENHTSVQEVVLSNFFSNDWANTEDNTLDPLFLAMSTIPNLERLTFTGCGGCALNCQQVSLVSTRALAAVFQNASIKELQLSFLELDDPQFETIAMEVAKNTSINSLALDYHNLAEYGFCKLMAAMETNRHVKNLSLRSLWNIGRRGFEEAMKMLRHNYWIESLSVTASPSQQAEIDLYSRMNTAGRSLLREPGTSMSQWLDVLAANSDDIDVVRSLLKEIPDLCKVATQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWP0</accession>
    <name>A0AAD2FWP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37358" checksum="2A30D7C1BB148241" modified="2024-05-29" version="1">MTSTDEDPAAEITAAFGTFDLDEEADDNDNKPTIDSYDPFGVGAPLASEPKKVSPEKKKSPVKKISPEKKDPPKKYLAKDVAPNSVPPLISINFKIHEEISSIAIMDPEMEGASEIFVQGGVMAQMTSSDAHKNSPWFLDAKTKTGEIVDVTPNVSYSKKWDAQKGQRKKASVITIPKATVGFVPIASYYFKETIEHMPLLLERRVTRKGDIVQVAVQVRSKLTNLYDLTDLSITLALPDPVIGEDVEVNVGEGIYEPVKRVITWKLSALQKGDSFMVSVRCLVNDDADDALLKFPIVLRCSSLDQISTGDFKAVEATGYPAAISSEVISRTFRLIHRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX48</accession>
    <name>A0AAD2FX48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoglycolate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS15623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001881">
        <property type="protein sequence ID" value="CAJ1955179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX48"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01139">
        <property type="entry name" value="C2.A:_Pyridoxal_Phosphate_Phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00039">
        <property type="entry name" value="phosphoglycolate_phosphatase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042248477" description="Phosphoglycolate phosphatase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1955179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38138" checksum="FABC0BDEE4C41323" modified="2024-05-29" version="1">MKFAASTTAMLATLLANTSAFTVRQSSAAAAFRTVGASRPFSHATKPLAANVMKLSEPQKELLDTVDVFIFDCDGVIWRGDSLIDGIPETLDKLRKANKKMFFVTNNSTKSRAGYKKKFDSLGLDIPAEEIFSSSFAAAAYLEQTKFKESGKKAYIIGEIGICEELDLIGVPYIGGPADSEKEPNMGPGGKLEVDSDVGAVIVGFDRFVNYYKIQYAQLCINEENAEFIATNLDAVTHLTDAQEWAGNGSMVGAIKGCTGQEPTVVGKPSPLMIEYLESKYGVDRKRICMVGDRLDTDVLFGTDNGLKSLLVLSGVTSEEKLLSPENAITPDFYADDINAFFQTEESAVEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXA2</accession>
    <name>A0AAD2FXA2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXA2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1955529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="56587" checksum="EA1C144D6F5B9D1D" modified="2024-05-29" version="1">MSEEEIDRARRKQMGIIAEEEITGLVERSRLEILDDVLQLDWDDIDLRSTIGYGGFSQVFRAGIQVSSIDEDAPAIADQEFALKCLSPNTMARTKSFKTGSVDLVIEATILARLSHPNVIKLHGFYGKSVRNSYLESERGYFLVIDLLADTLRNKIDKYRLQNPKMRKTRDPSQQMGSIKDSNKPNTSEALERIKSIGVDVAKGMEYLHSQGVVLRDLKPDNVGFDTNGVPKIFDLGFAREFHTLKPKEVAGSLRYMAPEIALGQPTEFASDVYSFGVLLWEMTTLEKPYKHIHDRDEFIESIMINGWRPSSSQMPSTALRRLVKECWHGEHTRRPNFSKVVKILKVETSLVATNSKRASGMPLPRTTTFSDASAISRKNSLGKIPSISKKTGSSFRNLMGFGKKNQSSDSMADLTKKTEDATISEESTGTATTGGTTSSSLQQPSSSNKNASFGASGSNKTKVNPLLAQALLGSGPKKSKHGKKPPKTKVKKSLYRAKSNMSMPNFFDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXG4</accession>
    <name>A0AAD2FXG4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXG4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="438" mass="49320" checksum="216CD4237ABB54F7" modified="2024-05-29" version="1">MSRPTDIMSTITEVSFSNDSSENSENEGLIPEVLMKGLSLSQVTEIYKDRLSEDNVVAIARRLLIEIGSKHEQKGQVDTDDWDDDSEASLGNGRINRNQHFCSIGIDILRRSPCDLLTGSELLKHHIANLSQSAPEEFLDPISFDIMHDPVVISSGFVVDRSTAINQSSGELQLATCPWSRVELSPELYPALRLKQKMTEFKSGRVDEMIETASLLLNAKNERDFCKVFELAQEFMDDIGPNGHRELAVQLAELVLSTLTLKPSDPSRLCILQPSVLTKHFLMLHSLKQATLVQAYLPIKAFQMSEMVQKAIGGNQFDEAEKWLACCTEIQDKCEDLLTGNKEIPLGKLHLDLAEKRGGNHLEVFVNRFTNIEMAFILRSWGFAQETIDEMTRCARVYVIRDILIVNCSDKNLERVFKTRLAEACDLTDVARRIFAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYJ8</accession>
    <name>A0AAD2FYJ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS15827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1955597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="21317" checksum="B4FFFD19C857F48A" modified="2024-05-29" version="1">MSKENIKLLPLSGIVSCYSAIAALILTGFKHGTSQYQGPAQSSTDYTPLLFVSGAVLSQLYAYYWLQSYTTFSEFFRLKKEAKAKKSDKRPPTLADLKYGNHDNLAIRCADRCAGNLLEQLIPFFISMFVYATFVDAGSAARIGWAWFTFRSYYSYAWKRFPLLFASTLPAYCCVWYMMGFAIYSAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYS9</accession>
    <name>A0AAD2FYS9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1955912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYS9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="219" mass="23984" checksum="2CA1BFD7B7F31FD3" modified="2024-05-29" version="1">MSLQTVMHQNQQTIAFLNARNYYCAVASSSSALQCLGSVPSMPQQVDLHSSSSCSFLCESSFDQCMLLTSIPEGDDQCAAHAFIYSRAIPLPYNVTDRAIVAPVLIFNAALAHHLAAIRTSSDSTERSFECLLRAKQLYSLACRSQDIELNPLFHFAVYNNSGLIDLELGKNKNLWKESVGNLVQIYMILVKGGCISRLRHIQGFLESLFAAMPAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZW7</accession>
    <name>A0AAD2FZW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS17290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZW7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1958666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="28382" checksum="FF85C4927BE72D5D" modified="2024-05-29" version="1">MAFRSKPLRSFGPTVIPHGQIENTEGNVTLGKIDHGVTENPYERRFSPYDFNGGTCIAIAGADYAVIAADTRLSSGYEILSRNMSKLHKLTGKCILGSAGCKTDVDQLRSVLDIKMKVYQHNHRKPMSTPAVAQMLGNTLYYKRFFPYYAFNVFGGIDEEGKGAIYSYDAIGSFERTAVTATGSGQAYVIPLLDNVISHRNRTDEKRDLPKEEVVELVKDVFISCGERDIYTGDQVEIAVITKDGIETIMFDLKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G013</accession>
    <name>A0AAD2G013_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G013"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32940" checksum="A675929BC7E1B8E4" modified="2024-05-29" version="1">MPNTKVVVVVRHGERLDYTMRERGENWISTTNRPWDPPLTENGKQQASALGMALPSMLKTLNLPSIAAVYSSPFHRCRQTAAGLCASDEMLKVQVELGLAESLNQNWFRSWSIEGTDGTWGYGKKECPDANDLDPSKLNPLSKVPVQPLLDWKQGALEEELKKKMDIDYESKSSIETPYSLRPPLFENYKTQQKRMHATLEQLSELHNNETILLVSHGGPVTHLYESLTGNTWDRHGVARYCCYSIYQQEEGDDKWKPLVVNRILGEEEEETKPTDEDATSSPPKDFTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0C8</accession>
    <name>A0AAD2G0C8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17486</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0C8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF289">
        <property type="entry name" value="GLYCINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="386" mass="41957" checksum="D1F3611C03206C9E" modified="2024-05-29" version="1">MSPHASSNQPIKILDSVGPAAASSGKAGALITNRPPLKRGNASDKRQSLFEKSFELHESLAEELKLESFCPVQNYQVVNELSDKTDEDRYQQQTNCAKLPLCLSNLENTHAGVELPGDAAIIDPAELTYALFNQALARNNDSSFLKATVRGLKLVDDNQTLQRILVEPGKGDCEIDYINIEKDEPVVIALGSWSASIEDWLGIPMPIEGVVSTSMLYNNGIPSSDIGTALFLDSDLNGCHLELFGRKDRSLYVSGCGESDVIGTEVLRGEGRPSPEICPPNMARAAAAQKSLKKLGYKECTPDIVQACMRPMSPDAIPVVGKILSNVYVATGGGPWGITWGPLMGKCIESLINDDDLPIRMAPLKPQRYDTLLYRTLLNSRSPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1E3</accession>
    <name>A0AAD2G1E3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1E3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="280" mass="30776" checksum="E93BD23B4BCBF3CB" modified="2024-05-29" version="1">MKTPSYSKALCIAAFVSSMAQEASAFTQASSLATSSSLSSSTSASASASASSNIELQASLASTIYFPGHNRSTGFGTPLDKKQENTPATAPPPARQNTMELIDQFKHDASVIFAIIDSDASGSISREKFANHLLRAKCSEQFVNELFDRMDVHGRGAISDSEFRSLYLTVPSLRTLPGMGQFATDPNTMAVGDELFQSLDVDGNGFIGFVELLVHLNNNKNNQFFEDEAMIKIFSLLDADQDLSLSKQEFRDAYWRYSAFRNAMIVEGEQEEQEREQEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1Y9</accession>
    <name>A0AAD2G1Y9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fucoxanthin-chlorophyll a/c light-harvesting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS18403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucoxanthin chlorophyll protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1Y9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030076">
        <property type="term" value="C:light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5" id="KW-0437">Light-harvesting polypeptide</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1959986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13382" checksum="2D418CA3B5A73CFD" modified="2024-05-29" version="1">MLGVVGYLVTAAGIRLPGDIDYSGTSFASIASGWEGTTQVPVAGALQVFAFVGFLELAVMKDITGGEFPGDFRNDALDFGWDSFDEETKLQKRAVELNQGRAAMMGLLALMVHDKLGNVSDFFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G273</accession>
    <name>A0AAD2G273_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS18313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002026">
        <property type="protein sequence ID" value="CAJ1959894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G273"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1959894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="108" mass="12046" checksum="DA1594DC911B6A94" modified="2024-05-29" version="1">MAAISLSVIDKNNKPLYVREFDQTLSADLLSEEQLFGFHSIEPNKEAVVSNSMTCSPRHQFVMHAALDKFDQLAGPIPGYGWRKPGLNQDTPCGRRRCGARDAAINRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2W0</accession>
    <name>A0AAD2G2W0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002014">
        <property type="protein sequence ID" value="CAJ1959640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2W0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="205" mass="22470" checksum="096C1D7AC61FE416" modified="2024-05-29" version="1">MNLHQFLKQLSLDNGVDSIAFVSDNARSPPRTSTARGQHLRRKRDHAMASKAHQYSSSSSCEESTVKNADDYTAARTKSAPISEPGNGTRCIGSPRSSSAFSHISKPTSRTEIIYEQAFRATQPPATTMRSSSAPTYLPSGDIERSSFQSPTAVVRTTVSVDMQPIDTCPKTFQLAAPSRRPQYDRHFKAISLSPVEKTRSMAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3A0</accession>
    <name>A0AAD2G3A0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS18858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3A0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="545"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="804"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1960716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1227" mass="137841" checksum="5787DA014158D7E5" modified="2024-05-29" version="1">MTRSKQSKDKFLMKTRSAVTDTNESGSASEDNSGEGGIMERMTMESTTDTDPTHHDDENAAPMNNDEFERVAIKCFRLFVFALMLAATIAAGFTSWFFLDREESNNFNQEDIKQVSQDRTSDLVAEFRSLSSTITALSINSKTNWPFFTDLNYPTIVANFMETAGVTMVAIAPFVKNEVDLQKWADYSQANQEWIPQSLLLEQQPDPSNYTQIFPGVFRNSAGGRIPEKGDGPFAPVWQMFQAPRDGRLVNFNMLSDPHYKEIFESLMEEKTGALSDRLGPNNAGLMENFPASTQYFVNRNPISMFIAPVFKDATNQEIVATVSAAFNWMNLFALPSGELTPPVDVVLNDGCANEFTFRVTGSVSEFVGFGSLHDPTYEEHERSFAFSPSLRTYHVGGTGCSYQVRVFPTKSFWDTYHTTYPASMAGVITAVFILVGIILYMYDAAVHMRQSKILAVASRSEKILSVLYPKTIRDRLFGIEEETVTEEQKSSQGASAIRRFNEDLLKKANKYQLKSFMKSTPSAHPHETDFLDTKPIADLFLHATVLFADISGFTAWSSVREPTQVFTLLESVYRTFDITAKRRNVFKVETVGDCYVAVTGLPEPTKAHATIMASFARACVEKFEDLVGSLETTLGPDTGDLGIRVGMHSGPVTAGVLRGEKARFQLFGDTVNTASRIESSGERNRIHLSQETADLLAAAGKSHWLSSREQLVTAKGKGKLQTYWLLTKQEEASINITSQTVDSAFTDDEASDDGSGIFLNSPSVSSEFSLDLGTSTLEDIEKSLPSRTRRLCQWNVDVLTRLLKQIVAHRLASDLGNKDWESDLSRREKEIRRHISVLDEVVEIIPLPGFDQSVYKGQQAHERIELSEAVIEQIRLYVACIAAMYKDNPFHNFEHASHVMMSVSKLLSRIIAADDVLNADQNAASSDDLLGWSIHDHTYGITSDPMTQFTVILAAMVHDVDHSGVSNNQLINEGSKLADLFNNKSVAEQNSTVLAWDILMHPRFQDFRRTIYAAPYELDRFRQLMTNTVLATDIMDKELQALRRNRWDAAFNTNAALAARSEEATKDMVNRKATIVIEHLIQASDVAHTMQHWHIYCKWNERLFQEMAVAYKAGRLPFNPAEKWYEGEIGFLDNYVIPLAKKLKNCGVFGVASDEYLNYAMENRCEWEEKGRDFVATLTARYMDDPNASTGMMMVQQQENKRSSRRLTINMDSRNYEEAIAQVGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4I2</accession>
    <name>A0AAD2G4I2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS19768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4I2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053211">
        <property type="entry name" value="DNA_repair-toleration"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060">
        <property type="entry name" value="DNA DAMAGE-REPAIR/TOLERATION PROTEIN DRT100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060:SF21">
        <property type="entry name" value="L DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1962611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="833" mass="91234" checksum="184EB066B5654A21" modified="2024-05-29" version="1">MSNNGHDNDNNNDNNNGNLPPPAAATSASLPNPSANSMNARIGASSVFSNMSEDERQQRYEAKMKSMGIHDAIPQEKPETESETETLDSLKRSMSVQSERNRNNSDNNNRSNSSAINPAGQVVNRSISLNPSTSNPTGTPSTTAHVDLVEQERQRRYDAKMAAVGLAQPEPEKEQPVLHPDHQAQMTGKLSVEPTSGEMANEADEKNAFSSPPAPVYDTDAEHIKEHENIKNLNYAHHKNNPNNMMDADLAVAMAINEEEEMEKGKDETIVYAIEYDPESKPPLHKNRRFQLYGFIGFLVVVLVAAGAAVGVGGGGGETTIVDAKSLQGELGPTNSPTVYLTPEEQVVYSFLSLHFSPKVREEGTPHHMAAQWVLYEDPYSQDILKDLSNVSGSLDVQFLQRYVLAFLWFHSTNIGKDPWRSCNPPTFKSMNLLDTLVTPSAGRLVTEGVEAGAEAEADADSDTCTFLQWNRLENDAVCFGAVPGVHRWMSSADTCQWQGVDCSTGTEVLGLDLFWQGLSGTLPSELMALTSLQKISFAYNQLTGTIPGEYARLRTLFALELHGNLLTGTIPDSYYEAASETGALVLLNVGDNQLTGTLDTRLGLMTDLKGFHFFDNSFNGPIPTEIGNLRYLSYSRGYGNNLSGSLPTEVGKLRQMNEFWYYQMGLTGPIPSEIGNMKRLQYLRLWGNDLNGSIPEAFYSLRKLEQVALQENSLTGTISTSISNMMALEALRVSSNKLRSTIPTEVGDLLGLKVAWFHQNEMTGTMPEQVCRRGLIGLQADCDPEGAAAVECTCCSSCCEQGLGLGTCFFREGYGEPTLPPNTFDDYVMCEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5X0</accession>
    <name>A0AAD2G5X0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5X0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042239026" description="Secreted protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1962591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="55559" checksum="DF5F1A0A66EC44AE" modified="2024-05-29" version="1">MTRTASNAIQGVSTLILFLQAASPTAGLVTPPQLETRRSTQLGAKLGPSFDGAWNPRKMTETVFENFSQSKESLMASMEHQKEVLAESMDQQKEQLQQLQQQQQKLMADIDLPFHKPSIHAMEDNTGFVLMGGHRPDIIQMTVTSQDSTASSSIASTMESSAVSETVLPQLLQESNDLLQVDSNANDAMELVASIDKQVDQQVAQLEAAKAAVLDDTLPTDTFDKVATDTAPLQHTGGVDMMTPQDMINKDGMISAIDIDTERVGPISTTEVMQALQDVTVNAKQQMSDTVAANKFHFLESTDNKGFEVKEIGEDSVDMLHKLGNGMVDSMKSVSNNLLHFVEEMMKGSKDGFSSSGLLQSAQESIQKIVDGGIESVMATVNSVGDITIRDMITNLVSLVALVVKVLFQLVSTLVAAASGKGVTAWVDQSNAAIHQGALALQDQAEHFSNDLSHQSLNEMVAMVDSYLHASTTYMADTATTVLSMGEMTGNLAAPLVSAIFTEGTISTWNALSDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6J4</accession>
    <name>A0AAD2G6J4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS20465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6J4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051667">
        <property type="entry name" value="Archaeal_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096">
        <property type="entry name" value="YALI0E33429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="712"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1964086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="754" mass="86079" checksum="90557D60586A1795" modified="2024-05-29" version="1">MTIVQRLFRGLTQSNLASRTSASTATKGLPSRRIPIRYQRHRHNNAYLARDYRKNGVLEVAKFALLSIATLPFTLWLAMFSYDYYYRVELCLEALKQEDKELRIRLHKDKQSVVHRGREAQLNQVKTLLSKVPHQVVLVAGVNECGKSQFVSEVLRDVNSSRKEKRGVTHIQLAQLVDSVSSFTYMLVNSFNLQWLSLRYSLVDVLPFAGSEILVMKERFSDRDLASALYVITEALKKHSQRKSKEERPIIVIDGLAEGKSWARTQEGKQCLERLFQWCIYVTKERQLAHIILTGNEELVLSLTDQNRLTRGHVKVIGLGDLQKDEARQVVLKEIPDASEEEVQKILDAFGGFIHDVRGSARDIQDQLGLPDSLNAKERARIVQDTISTRCRMQFERVTAAFAKGHDELDVASNRSTDDAMKAEEMDPYLDPLKAAYSEAQASQTSAALSDSDYTVSYTKLQLWQTLQMLVDAKDGAVAFAELRDNIFNGDQAPLLELMDDDVLGFEIEDSQRVGFSWKVKPATPALYGAFQQIVSDSSLKERFQLVEKNSDRQDEIREVVQKRMKIRKERKELEERKGAIQSTVELGEKLDRKGIASSKLTAVYEALVREEHDALVRDYELREKLKSLEQTRQVESPQTVSKTENEVQQHLKTAMLQIMTQNLSNEDSSLEGFDGNSALWAAFQELDATKDGTFAAEDVVRVIKAYTGKDVKLKDARNLVRDWDFDNDKHIDIHEFTRWYSSQDKQKKTKAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6W9</accession>
    <name>A0AAD2G6W9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS19393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6W9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050461">
        <property type="entry name" value="Nitroreductase_HadB/RutE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43543">
        <property type="entry name" value="MALONIC SEMIALDEHYDE REDUCTASE RUTE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43543:SF1">
        <property type="entry name" value="MALONIC SEMIALDEHYDE REDUCTASE RUTE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1961831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="256" mass="28562" checksum="B3FEE7A8C2C5CB97" modified="2024-05-29" version="1">MASTSSKASVFRSIARSRRSSRRFQPNRKIPDAILGDILESTLRSPSSFNLQPSQIILVQSNEMKQKLSKEAMLGPGNQFRTNDASALAVFLTDLEPTKRINRIYELEKNCRNPNYLNSLPMVSSFLIGEGHAATMIKGVATNFLSVVQPMPVVEPVQAWGYKNSSLLAQTFVYAAESNDLATCMMEGFDSRRVQEILRIPDRYAVPLAVAIGYEYEDPESFEHTPRLDVSEVVFSDTFGEPLRLEDDGENADETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G703</accession>
    <name>A0AAD2G703_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS21032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G703"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1965269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="388" mass="44037" checksum="5A8215F1BF81FB7D" modified="2024-05-29" version="1">MFSVRYCCTAPKNYIFWNSISSSRILILNYCGVLMLLASRWLSCSGLVSLSSARRNFTSAVACCQAHDSTRRMLVKDFPIGLGTFAIPPDHVPAAISSAIKLGYRRIDCAPVYFNEDKIGDILQQELEKDDLERKDLFVVSKLASPFHRKEHVKIGLQKTLYDLRLDYLDLLLIHWPTAFTFVPIKVNQRGYPDEEIDESDGGKRIDPTVSIHETWKAMEDLVEEGRVRSIGVSNFPVSLLHELMTQCKIPPAVNQVELHPYLQQPKLLEYCTKRGIHLQAYSPLGTPGYKEDGEPDVMKDPVLVEIAKKHEITVAQVCLVWALQRGTSVVAKSASPQRQEENLAMAIRDPKIALTEEEMDQISDLDRGYRFFRPEDWWGSMGMAVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7H4</accession>
    <name>A0AAD2G7H4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M11 gametolysin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7H4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042107853" description="Peptidase M11 gametolysin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="91299" checksum="74BD4378D676B1F7" modified="2024-05-29" version="1">MDALKSAFLFLAFYVATSAAGNMPYDISDTPDSTGVQANAQKLPCTLFIRETDYTDGSDGSDWECKVSSKDAQSAGASSTARSAMVAIDGIDLVLAAKPDIKSGVTTLFAEGAILSDRTLTIIASNTLSFGEIVSSSSRRKLSAKTGPLEVLVVRVTTKDGSLTKDAAGISDDLFGTGTDLVNFKSQTEACSNNAITITPGTGSGTGCADNTGYSAGTTTTGEAADCDWFVNQMEQNDGRDECSSAVYGDFIDVNGSGQSAREACCICSGGTPQSYNNDIMITDGVIDISVNVNANGLNRFDLEDLVENQLEDLFYVNDLGSRFDNVLMCVPQGTFRPSDNSIGWIAYAYVGGWLSVYNGDDQCNDPSTHLHEVGHNWGLQHASDENDCIEDRTAGGYCNIEYGDMTGVMGYSTLNLDDEIFGNKYCFNGAHSWQLGWYTAYEEEIDPLTTAYIGKLAGVGKLPNVGPEEKVVLKLAYPIQDYYVMYNHAIGANEGTVEGVNTVTVTSKENDAQAKTFLLAELQSGAWFTAQSSDGVSLFTIYVTAIDDSTTGTADVEVFPGALADRPDTTVVTTPAGSNGDPHFKTWKNEHYEYHGQCDMILVKDPGFADGLGIEIQIRTKLVRYWSYIKSVAIRIGDDILEVEGSADPSTTTSDLRYWYNLEFQSPMKTLGGFPIIIKKREYSHYKRGLEIDLGPIFPGEKIEIAAWKEFIRVDFQNASAASFGNSVGLLGDFHTGKTFGRDGATVHDDFFRFGNEWQVLPYEDMMFHIVEQPQFPKHCIEPEDPQGERFRRRLEESSIEQKDAEQACASLMDALDRKDCVYDILATQDLDMAGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7I5</accession>
    <name>A0AAD2G7I5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002213">
        <property type="protein sequence ID" value="CAJ1965640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7I5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1965640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="119" mass="13221" checksum="14670B88EA1E86D7" modified="2024-05-29" version="1">MAMLKIFQYVATTAGGSDNVDPTMMGVNAQRKAYTCKQKENQSNAEYLQAFMQLSRTARFCDYPMGASLSRLVKKKTGKSDPTLAELKAVEEKIVEKEMAMVFILGADKKQYGSYCPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7Z8</accession>
    <name>A0AAD2G7Z8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002128">
        <property type="protein sequence ID" value="CAJ1963075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7Z8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="390" mass="44126" checksum="7B6DFA47A822EEAE" modified="2024-05-29" version="1">MRHFGWDIVIGLRYEWVNIPYNGCSKWNERAPGCMMWHVYVRARHAKRVDRALRLWLHPLTPKKDFPWCVVTHYISDWKAAQNGIVSVKAVGPVKDEKLTIISKHNDFVELTQAKYCPVKIPGMLKQATTKDFGPRTCLSMFLSVKARPLHADKVAAADVDTDSEFTKVSTKGKMKIKKKVPKTSKNLSLENKGPVLTPAQQRRARESERKRKMDLENNVPSPLFIMVLPGKMEGTYLFISRLKYAALATNVLKGLVPFFTHHLGESTTTRSNRVLGKWFPKSLIHTTRRKELVWCLETLRARPADQTQQGIDKAIDFLDGFGSDPLDVGEAKLEFDMDMADAKDIDDGATVAGAMDELLEKDSQLEAAITEIEFKDNLLSKQNSALEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8L7</accession>
    <name>A0AAD2G8L7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8L7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010710">
        <property type="entry name" value="DUF1289"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF14">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06945">
        <property type="entry name" value="DUF1289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="49"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1963771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="321" mass="35900" checksum="5EA82E5BB80B6B0C" modified="2024-05-29" version="1">MTVSKQSRSPRNRRGISFCCSALSLICFFHSHKHYALAFSARRPFQLQHLDHIVLTFPEDINPMMEFYTEILGCTIDSPEDIGRLNGRLTHLRAGPNTMIDLMKRDDDEDSDDATDNDDEGHRSSPSSSSAAAVDHFCLRIDPYDQGELEDYLQSKGIEIQSSGMRKGAEGVGPSIYIQDPEGNTVELKGPAMEKQSNDENQKEEKGTPSHNIHEPTATATTRPKDDYHDDSDQTKVPVTPCTRICRYNADFFGGQVCIGCFREGFEVGTWASMSPFEKYMGLLDAIDRCNESSIPLDGAISLEELQRQADYWKNLSLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G922</accession>
    <name>A0AAD2G922_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS20597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002180">
        <property type="protein sequence ID" value="CAJ1964367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G922"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1964367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="35029" checksum="253F25C17A405EA4" modified="2024-05-29" version="1">MSGSQEKHNGEPSSKTIRLMVDRESCAIAKAKPYSLSSVDKSSSTLNRITRPSSSDKSSEKMRSAPPVKGIRSPEIAQMVSSDEEAPNKRKRRLSKRSKSDIIESPSKPTVPLPDVNENISPDDYLLKLVEAQLGLKLEQRKAMEVKDFFHESTEEEKAAYTTEVVTAVRDEQLDHLEKMRENGQELNCFNRFGESLLNLACRRGFQSIVRYLMDQPNVTVKSSDDCGRTPLHDACWHPQAQTTICKWILEEEPALFFIKDKRGCSAFEYARPEHWPVWRKFLLENRESLEKLQDPVIKSMLSKQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G962</accession>
    <name>A0AAD2G962_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002312">
        <property type="protein sequence ID" value="CAJ1966661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G962"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="209"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="577" mass="65919" checksum="484EAED67E89CB56" modified="2024-05-29" version="1">MPAKNRDRQVQEEANHFVSKKANNPKPCNHHKPSLEELQRTTFSDYVRNVVLQKAQRDVEYSDNEAPRVDRELLERAPIHYNNGIAKVTLPSEFNDKSGIANDESGRGPGWAEGTSIGNITLPSPIKQCVRGIGGIYEFTFLDQSPIKVSEFRKRADQYFASQVGGKSDLSVEELERKFWRRLGPTQEPSMYGADMNGTLFGDDDCFGWNISKMRSCLQLLQAEQKDCHDDGIPGVTTPYLYFGMWGSVFCAHSEDMNLLSINYLHAGSPKVWYAVAGGEDAKRLEQFYDSNFHEAKSQCSEYMRHKRCLISPMILKKAGINFTRTVQYPGDAIITFPGGYHFGFNSGFNAAEATNFAVPEWVPYGKLAHVCLCRPDSVRIDMKRFERLLLKYEKEVKQKKRLQWKDWAMRVVKKKMKTERSHESAISIEAAGKRKSTSQRKEIWIEVQTTSRQPKSRKRKQASKIEVWHLAKPGSRKAFHPDVRVLCLTPTVADSCSSDSEEDEEDEHCFAGVVVEVREDHARIRVDGCSKKDDVWMPLNSPKLFLDGGRWGDDGTDEDLPPLHYWREEDSKRRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAS2</accession>
    <name>A0AAD2GAS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dehydrogenase/reductase SDR family member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1967011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAS2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053011">
        <property type="entry name" value="SDR_family_member_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37460" checksum="D9E9E46A0C8A249B" modified="2024-05-29" version="1">MMMSAIGYVMAAGATALAITFAKIDANPSLFITDFMASERRKMEYFDRKTMWITGASSGIGAQMAMQLSRYGVNLILSARSEEKLNDVAQACREASDKNNAISVLPLDMTCSEEELELAVDKVMEIIGNGSLDFVVMNAGKGQLKLENTMTKKETEELFLINAVAPISLTQLLLRKKILRADRGKNLMVTSSVGGKYGLPLSASYAASKHALHGYFDSLKAECPWLRIDLVCPGPIDTAFHYSKEGQENAKETKSDVREMKMPVDRCAQLMVSSFLVKGGGEHYIAEQPSLIGLYIKQLFPGLFQVMLGKVASLRIQAWKEGLNLYDPQTWKDMRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBS7</accession>
    <name>A0AAD2GBS7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002354">
        <property type="protein sequence ID" value="CAJ1967923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBS7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="167" mass="18209" checksum="45C863CD68ED1DB0" modified="2024-05-29" version="1">MPHPTESILITNSGADQFLAGYVWRRLGITGRHIALTGPIARRDIGTVLPVSSVAAKIIDEHGNTYCGKAHEVLHDTNPHQHESLLPPAQARAAGNAVDECPSDALTPRGDYGTQCCVISGHTLPLFFDGFKCYYSVEAITDEEMRTLPEIVFTSDEEYEPSARSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDC3</accession>
    <name>A0AAD2GDC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002513">
        <property type="protein sequence ID" value="CAJ1970408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044241">
        <property type="entry name" value="TxlA/HCF164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47353">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN HCF164, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47353:SF1">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN HCF164, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="229"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="378" mass="41219" checksum="C9D59123C6D4A5B0" modified="2024-05-29" version="1">MQNMIRLSQNITKMALLAHCIAMVMQLSSPEVGTVFFADALFVNPSPSSRITVGRNNKLCSVSGRRGGSATRIIRSHHDSSRQAQHITLKSSFLQGSASSDDTNSTDAVDEINNLSEPPTVIVMDGHDTDGGAATSSASTTAQFGDVVRLGSGNHQQSETSEEDSAFFASPEPIFSNKPTSSAVSEAEKVAKKRKEKNIFVAVASVGLALVNYFYQFTHPLSSLQLLSTMQHDHAPETTLQLLGNNGKPTMVDFWAPWCENCKQLAPTLYQVQQQYGKDVNFVMVNGDDPSAWPLIEAFGVDAIPHMALVEADGTVDTALIGPVPKGWIDADLQVLIENSRQQQRGDTETPRKKLPYEMLDVFANRPEARKLQVTLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GEL0</accession>
    <name>A0AAD2GEL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GEL0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043957">
        <property type="term" value="F:acryloyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08288">
        <property type="entry name" value="MDR_yhdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014188">
        <property type="entry name" value="Acrylyl-CoA_reductase_AcuI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02823">
        <property type="entry name" value="oxido_YhdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF1">
        <property type="entry name" value="ACRYLYL-COA REDUCTASE ACUI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="32"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="351" mass="37064" checksum="68A302CB64AA5005" modified="2024-05-29" version="1">MATTATVSSSDPPSGPFHALLIEDAGSRKTKSSIQQITVDDLPPHEVLIKVAYSTLNYKDGLAVAGKGRICRTLPMVGGIDLSGTVVESQSSKFQKGDAVLVNGFGLSETQWGGYSEYAKMKPEWLVPVPKEFSLEQAMGIGTAGYTSMLCVNAIRDHGVKPEDGPILVTGASGGVGSVAIHLLSKLGYDVEASTGGSANHDYLKSLGASSFLDRSDLDRDSKPLEKEVWAAAVDSVGSKTLASVLSQTKYGGLVAACGLVGGMDLPSSVAPFILRGVTLQGIDSVMAPMAKREKAWKDLAELMDAKILSEIYKVEPFSQLPFLADQIVKGEIKGRVVIDVGQNYPASQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH02</accession>
    <name>A0AAD2JH02_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS11777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001755">
        <property type="protein sequence ID" value="CAJ1948777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019309">
        <property type="entry name" value="WASHC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015">
        <property type="entry name" value="PROTEIN AD-016-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10152">
        <property type="entry name" value="CCDC53"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 tensin-type" evidence="3">
        <location>
            <begin position="363"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="1207"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="833"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1197"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1631"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1767"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1825"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1904"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2325"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="863"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1688"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1925"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2338"/>
            <end position="2352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1948777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2366" mass="263764" checksum="BA08F826DB66135D" modified="2024-05-29" version="1">MNVLLDDLVDDIFHQVQGSLVPRIEAVTKKATQELKNRLQTPPSSVDLLYLTDRLIVSSQPTASSNPSYIDNGREKRPTYAQLPRPISGPQTRNPITSHNDNDISRRDSDPQESSSTTPSATENHSGRALKASTNEIRGGIMNLYEGETSTGEKSTPNQYSLDSPVADTKNTHRNSNGDKVSASTMSNEEAIHDSNKASSSRVPVTAQNSPGIMTSFLDKRHGSDHYLAFSLVDEQPDDRTLLLFRRQIVQLGWWSPCVERSETPSIPNILKTCYAIHAYLKLHHQNVALVYCSNGKTRTAIVVACYLKFAGIVKYSQEGFFRFLFKRGVKNPETTWKQLPPTLRLFFRQFDTALNIGGYLNRKPLLLRAIALQGVPVEDKPCLDIWDSSQRLVYSSHPEIWASDSTSPRNSSALSQWIDEEGFYKVDVCLDGDFLLLCRFGGDFAKDTAMHDPSKILFRYSNNTGFLAGGCPYELPSKKVDLTKRYALHLDHEDFLVTLLFQADWDETEGSKPETTHRLPRGLGDKLKSKEGVLSEKVWCSHHRQAYEEGLKVIFQHHSARPDASDIKAFRTLHDERVFENCAGHLICLALQLTNFSHNRTNNLLLSSPLFAWWRLPSDGDTSTESPFISSNFQHDKVKVPKNEEMDLEKDGDRLQKMFGVLNSIDVSKNLDSKDIASFKELDERRKLHETNSDSGNTPKRRNSAIRRWEQSRKEVCCHDVGWMVSGMTYPRPGDIVRCFGAEYAELNNRFPTPTLESICLPKVPFHPDLNPIFYRGRSCTRSNSQQNHYSRRYDRQRGISTQVLLQMQHTGVTLPCLLDLLRESQKWDGLPPKAAANMEKEGTDEVGNKSKESTEGSMNCKSKEQKEKEWKEARNAEELEKSRNKDQRSQDAGEQSPSQAEETTISLTPWNDDPEYAKYFKMLKMGITSAQVEHAMKRDGKDPLVLKLNPEKSLEEQMPEQPDNDAGDVALKEDPEYEKYFKMLKMGLPRDAVKNALQRDGKDPSVIDLDPTKSLGSQLLKHSEGKNPPLKDDPDYQKYFKMLKIGMPVGAVKNALVRDGKDPAIIDLDPGETFKSQTGAKEDTGIALKDDPAYTKYFKMIGMGLPIDAVKNALMRDGKDPDVMDLDPGKSIQFQLVKNRKKDTAIPLKDDPEYAKYFKMIGMGLPIGAVKNALERDGKDPDVLDLDPEKSVAYQLKEASTSRKSPTKKKKRVRRKKIYWNPIDPGKLKENSMWHIVRDVVDMNKLNYDQKEFEELFTESADPKDAKKMKKPEKAVKKLVQVIDPKRSMNGGIILARLKIEYGKIADIVNKMERSKFDSTQLSALKEFLANPDERRDLIGYMQNSKSPKEVLYANLSETEKYMYKMIDVPGASEKIDAMLFRCVFKNRFDDVNAGINTLNSACDQLRSSEKLRKLMAMILTVVNEINTGGEGNMAIGFTLDALLKLNEAKAFDKKTSVLHYVVKLVKKNDSGLLTFSNDISSVIPAESVLLDSLANEVKALGQELVGVHNTVQAEAERLEEAGELKPMTLEDLKEQRTTVRQVGNISQFNKMDHHTGRTPMERFMVDSKFSCDQAIVSIEDVRKKFLAILQYFGEDENMPTGDFFGILRRFMREFQKAVDQVEAIEKKETKERKRAAARVAKAAAKDADKSRGRAKKGQHGSSSALQPKPKGKKVLNIPKERDIGGTTTRGNLQTIKSTRHSKQQTRSDLLLAMAAAAASRKGRQFSGVQPSATAQAKKINSNVNTEKMVGGVETGGLDENVLGNQETCPAPSTAPLQPADQSESSIDVLHMQKTESKKEEMNRSISSKATKTSLPLDTNMITPATRGIGQKNCDKNKTSPSVDLQKCRPAKQREDFVDIKNDLHPLTNSNPVPNHSVTVANTAESGCGKSLTTVFDNGKIGIEKTKPQNGMEKGAQEHQKATEPQTEGQLPTNRSNSVHQGEPSLLNTKGMQNTIEFSMGKPSDGTEQKRQAGPHPVPVPSQRKPQTTENVMKEASEDITRAILDPSTQPQANEAAGHDEKTTETIMLMHTIETLDSRHSQGPIALQAGSVESFSEPRTQGSKVLNIKLDKERSAVDPTYQPETSLLMEKKTSSQSLFGTNDPKPMKEQTRSTSAVESVLSAPLSLQLIEAKKRTESFYDISVVDSIPQEGMEVGMSQTWTDGEDITNWMPWAGEVIKACDSDSVVGFEMPRDLNDGAEFDDDSTIASSTSFASYYDDISVGSGLNTPGKMAPPHHPTTPFDPYFDNVEQPPNQFMIHTRGRPATSMLFDDSQPPTVNLSQPPFQRFDSAKLPGGTSTPRDDVGLKPGLSFGADVGFDDGLGGFGAISNIDNNNEDGRDISKAGTESKRKNAWFPWGGGSGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH50</accession>
    <name>A0AAD2JH50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS12545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001763">
        <property type="protein sequence ID" value="CAJ1950351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042244546" description="N-acetyltransferase domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1950351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="278" mass="31161" checksum="18134747D908F00C" modified="2024-05-29" version="1">MKRPRLLFALLRSSVTALATGEKTRIILPQTQNIQVRLAKKSDISAIQRCNLECLPENYNSQFYQSHLNQWPELAVVCEDVSDVPPDQTGLSFSFPNVAESPPRIIAYVLGKIETRPVKNFDGAGYSKEQVETLGHVTSLAVQDGFRRLGLAQAMMRQLHHHLQHQGIKQCGLHVRTSNEAACRLYQRDGYEIAQIIPAYYQDGEDAYFMRKSLPESSANSAGQSLFFSNRIWKTGPAELRLPRHHIVGQGLSSNALSEKTASSPEYFRGAVITEAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHP0</accession>
    <name>A0AAD2JHP0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001761">
        <property type="protein sequence ID" value="CAJ1950320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHP0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="415" mass="45844" checksum="D1F99B843D5C8E63" modified="2024-05-29" version="1">MATVAAEAPSKKPEDVRAAAMAVLKLADERTEKGDTVAKHRSPLPANSPGAKRNSLSQRRGSQTDKRGSFNFLSWGKKQMDDMKEQMNKLDEKFLAMQFEQEEKIKKVYDKKTAEWSEVLTPQKKNNPRGTPDTPTSPAETPPIVSSIKETLQKDMDKAKEDVQTTMSRFRTSFAGFTQKLVAPQPQVPLKPPSVDEQIVAELEQLHELMTLCHTLLAEKDDLINQIDYDPDPRLPYTIKKLEASLGRMDQLMEAGIDGQFQDDTTQICVSTYERLILTLEKCNSPLVKSNAFAFAKDLEGDSEFDETSAAATPAPALDTSTDTAASKTTTEEAAASTTEDKPTETTTTTAVTTPDLELDGLDADMDIDLVAFEIGSDDEDDILKNLDADEKKTDDVANQANDSADDDFIKDMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIR6</accession>
    <name>A0AAD2JIR6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIR6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="282" mass="32593" checksum="8A3208B8456B8AFC" modified="2024-05-29" version="1">MEPVGIHSNDMEAINFQLPQVQNRGSHHYNLSSLGTEVDEGHFSSKPQTRRQRKKLQKPRLLPNPEEDPVDLEEDPSNPFSGLLGDTQRAKFDKPRPLPRRGLSLIEYPQEGPEEEPWDEEMIDQRNPQRSASVAEYSRRNNPDEMDPPNFLHRRSKSIRVPSSSKRDFQPKRNKSIHSKFSDVKCQENEIWVQTFIVNENGKIEYYFKGLRGEEYRLEPPTGALNIVYLEDVVGGENDDPEVVDSIKREMAMPSIVKKGKKKSRWAPFIKKCKSIRKLASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJJ4</accession>
    <name>A0AAD2JJJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS15831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1955603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="376" mass="44033" checksum="1E92079323456B25" modified="2024-05-29" version="1">MPPMLHRKPQHHNDNHHHHNNTANGNANNANGYSPIRNTLKLSISEDHDVKKTLNQSAMRRRKNLYKRIRVFIVTSGILALLYHGYYEGRRYIQSRVPSVSFENPNSDDSSSQQLRGSNESDEGATIQPEVCFITASYSKKKKEMDKLLVINNKSPYLRFYLFTNLNDQEWSTPGWTKIVTHFKYRRIITHSRYGKFLGWKEPEIQECKAVFYMDACLRPSENQTMWRELADIIATDETGTGLMQWPHPKNRSGVIGEFLAIKDSKKDIDKNIVKSLQWMIAQEDLDVKAKIYMNENFGYDPNSQVYRELSQAFWDQYSLEEDSWRDQPLWAFMLHRYNITPIPYPVPYKQVWQRNDGRALGHHGHAYTSEKDVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJV8</accession>
    <name>A0AAD2JJV8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001947">
        <property type="protein sequence ID" value="CAJ1957668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJV8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042141879" evidence="2">
        <location>
            <begin position="20"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1957668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="685" mass="76687" checksum="4AB036089AC44F07" modified="2024-05-29" version="1">MYSAVSVVLLLLGWWFLFRDNDDDDDAAAADGHGAESSSILSETELLGVTKSFQKDGKRWYIYSGQRHFPKTAKYVMIDTAVHTIKDGAFKGHQCLLRVYIPRSVRTIGMEAFEGCTAFEGCTALGTVRLEVGLRAIGEGAFFQCLSLRNIVLPPGLESIGNGCFCYCRSLRRISIPLSLATINDSAFNECHSLVEVNLHKRLKVIGPGAFGDCKMLQEIELPDGLETIKHRTFEGCTSLQSIAIPETVELIDTQAFDGCTSLTAVKLGKQGRLKVIGPWAFHRCLQLESVELSKGLILIAHHAFHSCVSLQTMSIPGLVETIEEFAFGSCRSLIELNLQDGIKTIGVRAFAACSELSSVAFPISLKWVRDGAFADCQSLLGVEIPAKSDMVLDDNCFRFCHSLVNISIPSSCDYAASNNILEGSDLLVGGPRWRDRFEGLPIHKVCYHSTPVLTKKGLIKMIQSQNVQLWEDAYGLTPLHLIATSTTLRHDIMECLIDSCPEKIIWHQDFRSKTMMDYILRHTSQRAVPLIKMVLYKLVVERVSSWDFGDKWRAVLSLWLETMQNDHGFGSRCDVLEHFFDKVGCIIRIEVTSLMELALWKMRMNTIGKEDQETSDDNDFRRRCRFQSGAGVVIENVMEYLWHGESETHTGLSMFPSYHSHSQGLPLQGDGRNSSRWSNGQHNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK96</accession>
    <name>A0AAD2JK96_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="342" mass="38608" checksum="30BAA1209E855663" modified="2024-05-29" version="1">MAYNCVRFVEKQDAEATPTVSNSGITNPDHEITNTCNAVTLSSSSTLSQDGNINAARRGTKRPFNETNAVNLDDTDDSNTSASPFRDRVGPSDHDMVKYLLDICESDPNFKHVFLFQLYPERTNLDQSLAEATAATRNTEKQLGATMSENEMLQKSNEENEQRIAELEAKLVSSQRREEELKSSIMEELKSALSLRTNLEKSLAESTRATQNAEKQLEATMSENERLKGNEQRIAELEAKLDSIKEDHQAALSRNRRLRTNNGALRTSNEQNEHTISGLEAKIGREKDLEEISKHYEDAYKSMAEKNGVLEGQLQAVKDWFENEARLRQQLEDQIEAIRRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLE5</accession>
    <name>A0AAD2JLE5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLE5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1961337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="111" mass="12365" checksum="3C4EFF40339998D4" modified="2024-05-29" version="1">MLGEKYACEIPEVLKKFTLVTKGDAAIGAHSMYVSNLSETDIDPDTSASKTFDGHVWGGYIPPREERLEDGSIIYLRNMTFNGDTTENVGLADAGIDWAHIEWLAQNLEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JM47</accession>
    <name>A0AAD2JM47_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JM47"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="32"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="236" mass="26823" checksum="0744A8498CA16403" modified="2024-05-29" version="1">MHTDNTASRIETHWCESMSEPFPETFKPGKWDVLCCGGKEAADHAGNRRYRVYIAKNIAAYSEAKCRWEKSMIVDSIIELVRRGSKSHCGGFVKKDTSSDRWYPVGNKPAREKVSHALRDAIKAQRKREERMRRHLATLLQRAKRLPQVIQSDYTMSEATLLSSSAHRNKDQGDDFPVGAIVSDDEDDDTLFSHEGEIAFYHDNNEWEKSLQASTESFLKSGESSEICFGLPIYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNL4</accession>
    <name>A0AAD2JNL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hflx-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS22500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNL4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11060:FF:000001">
        <property type="entry name" value="GTPase HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="entry name" value="GTPase HflX, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045498">
        <property type="entry name" value="HflX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229:SF0">
        <property type="entry name" value="GTP-BINDING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="GTP-BINDING PROTEIN HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19275">
        <property type="entry name" value="HflX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="8">
        <location>
            <begin position="379"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1966914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="633" mass="71574" checksum="EAC1B642F769E3EF" modified="2024-05-29" version="1">MKRSTLLIGILASTSYSDAFQNAHSTRAANSFDAALGKRSREDSRLFVLSSPPQSETTNHHDEGDSDIKPPLDPLFQMDDVKDNDLYHVEDTADDDQKEPTQFAELVMEEDGEEEEPEDDFSFYYRDEDDMLTEREDRLYVDENGFRRKVERCFLVGVEALAEQRRAKWADQYYDPLNGAAGAPTFSLEESLIEMRDLIKTAGMEVTGEITQRLQDVNPRTYIGTGKVKEAQEMMEELGCTTIVFDAELSPGQQKSLENIFNRNLLNNDFLVQEREIKVIDRTALILDIFAQHARTREGKLQVDLALHEYRKPRLTKMWTHLERQSGAGGVGLRGPGESQLEIDKRLVRDRIIVLKKKIDDIQKQRSIHRRGRKRTGLPILSIVGYTNAGKSSLLNYLTRAGVMAESMLFATLDPTTRKVKLPGYRTHPEVLLTDTVGFIQKLPTNLVAAFRATLEEVQEADVLVHVIDVSNPSWEKQERAVNAVLADIGIEDKPIVRVLNKIDLLDPEDAEYLRYEAAFSDNTVAVSALYGDGLQDFVACVEDAMSDLLVPIEMEIPYDKGDDLNMIHEQGNVETIDYREKGTYVLARVPTALANRLEKYSLAGSEEPVTKEGEEEIDWVAIGRGRHSVENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP14</accession>
    <name>A0AAD2JP14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS23305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP14"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1968579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="452" mass="49478" checksum="4DDBFB3C81D7907A" modified="2024-05-29" version="1">MDTIRKRTKAAWTAPKNAVRVEPKTYFANERTFIQWVSAALFLVTTSALLLEFENGEGYAKSTAITLLVFALIIAVYSLGLYYLRIWLMKHGRPYGYTSHFGPIVLSGAAIAGTWIILSRLRQLELADLAARNNGDAEPEVLAFRPEAGVCMEHDVSSFSPLEFEPSDALIDEDRNLLLVPTLSEIYGFPLPEWNNQGQLAIPEGSSATVVARVERGDFESATFVDANTLYAVSEVATATPDMAAVVYSFQRNLLGNFEISGQWKLATPEPEGMAFVQQGGTSSLYISGLQGTTNAPSATIQKFSVPEPNGLTQAVQGSRPALRASRLLNTKLLDEDMEDPKIGAMHYFEGILYVLHDNARVVRAWDIATGTFQAEWQLPNVPNSNGMQWEGMSLQRVQRSSSALRGSDGDSILLLHLTHDTPAAIWSIVVEEGSVRGSIVFPECAGVTVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP19</accession>
    <name>A0AAD2JP19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS22436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP19"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="167"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1966853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33057" checksum="F9B1F7EC56763878" modified="2024-05-29" version="1">MTTPLLNRFRVSSQAPIRRYLSSSTTGPKISGPAASKTQGIGSGKGAAGTFIKDRGPVSWPSLFLVSIAAASCVAYYNIERERRLETAMGRVVSSESGGWSPNPEVMAPRKFELTKWGWFPKDDGFGASGKPAIGGPWSLIDLDGNLVTNVSFQGKWLLLYFGFARCPDICPSEMLKIGRVIDQLKETHPELASKIVPLFVSVDPARDSLSALKTYAQDFHPDFVFLTGSPTQVQQMAKKYRVYVSKAEETEDGDYLVDHSIVVYFHDDGGELSDCFTQSMRPKDIAEKIVERMSNTQPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPB6</accession>
    <name>A0AAD2JPB6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002331">
        <property type="protein sequence ID" value="CAJ1967491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPB6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="933" mass="104815" checksum="94704F3B5EC96ACE" modified="2024-05-29" version="1" fragment="single">MGKSPASKATSANAKKLGVAKSKASSVGKKAMKKRLEIDLEQPKDRDPVNSNDVDIKQIADDQDALRTADEFEAQRIAERESRRREDYNKLVPKLSEWWSKKLYCGEAVNQAMQRMDRIQTGNALFAAWDDRYPGAWNQPCLRFDALFNDYAGTSTCNDRFLQIFTYLNSDNAQLAQYLISSFDLYTIEDTAAEDVWSLRVLAMRISLQNPFSFFDIDEFEKTQNNNQFFEGDKSDPRLRLENPLVGFWLICSEMFDYPWATTFDDDYYNEPSLSIICGIKQKRLAPFQSFFRPESSNHHIQHATQKISDPMNDHLDNAVGQSHLNKTTLVDQRKRHRNLTDNRYEALADEDGSSGGNADNAEAEDDDATTIDGDAYQQPNQDDDDDEILVTAVRNNPRRPPLSSDDEDDGNEDDDDNEDDDAVSNGEVVQTESVEALVRSEDDNMAVDSLTSPTQVSQDSSSLIHTPPPTRRLAPQPTLAEKLNKLIQVNLDGMTCRCHIFETTFATNFSGSDSGTVAEAILSAVLTSMEEALNNSFHELKILPISDNTYKQQNRWIRNSVELRNKILSYRALSLYCDMECGNSPYAATNSKPGEKKLRTRMQFGFARDTSEEAAQDYLHTGLRSQGRGAGCYPSPLQYGDIVKVGCFAFIPPEVNFDAYAKEIMRHFDFSIPIGIKMDWVSTPYTGRAKFNERSPGVTSPHGYARKIHAKRVDRELRSLLNPSTAKPDFPFAAPATFISDWKSAQQGLISVKAYGPVKDATLTLISKLRDYYILTEVLYSVMDLPGMFKFATTTMFGSCTLFKLLLSIKATPAQADKASHVHQSTTETDDSDDDSDDDSSDDDPNESSGPKGGQFTEVRSKKAATKVKKKAKKKKKLITDNENPFLNDLSPAQRKMAEVADRKLKNDQERHKSGPLFLMVLPGEMEGTYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU93</accession>
    <name>A0AAD2PU93_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1948925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU93"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="261" mass="30222" checksum="E73A0BD293DD8137" modified="2024-05-29" version="1">MMMLIKSIVPLLANPFHSPEMKNLRFQTDLSNATPPRIKKGVKFADEEEVHGVLRRRSQISRKSMDGIWFDGEDFESFIDDIEKSVEKLEKEKQWKSNEYTSLGLECQTEKGSAIRQEYQELARDMVLWEQDQQKKEGRISSVQLAEAYREASRDAEVRAVKLARQVSDEALEDYTKSGLMDLLEDGSSSSFMSLSVIEGGLDEDLPRTKPVRVRFAEEPVVHEVIRRRSQISRQSKKAIWFENEDFDAFKDDVYMLVSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUL1</accession>
    <name>A0AAD2PUL1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUL1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1950188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="90" mass="9639" checksum="589AB8A6D0268CAC" modified="2024-05-29" version="1">MGVSESPLSMADLRKKMTPSAIFSSEQELVMQAAFIALKLKEKKAASVKGSTRRPDMSNGAAIAELCDLCANTSPLKDTTTNDPSKNESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUV9</accession>
    <name>A0AAD2PUV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS13777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUV9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23011">
        <property type="entry name" value="PHD-1st_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="310"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="684"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="769"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="790"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="857"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1952909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="896" mass="99804" checksum="D71859E689CFAF6F" modified="2024-05-29" version="1">MKKNKSTKSKRKTKNDPLKVDRLKVKMPKIDKVDLKVKMPKIDADSDSSTSSSSSSSSSSSSSSSSSSSDSSSSSSSSSSSSSRSRSQKDPKEATQDDTRTKEGIPKEVTTSSPGKDTTTSTRAIPRKKRKHNDDDDDDETKDATTKTAAAHETTIPAQKMSTPMMTKAKSSHKDAPATNDAPTSTARKRQKRKKNLSKRNIPSLYDDEDDDNSSDEDDDSRMIGNTKDYYDYDDEKDPEQGLSVRELKMQILGRDVDSSNPNSQQRRPMIAADLDRHVLSKVPATKSVTPTAVTDSAPSKAELKNELTCIVCQEVFLDPISLPCGHSFCKNCAEWWWLQPHKRDRKDCPTCRQKVPCAMDSDTPHIEINVALRACVMALFGDSVKKRIHATTAGEHGGKHSRGYEQLIPLDQDFWRRIDYNTSMFAKKESFFQIRHSVVLDDQDQQMQLGLCLFGRPEQIVDDSSTLIIRLVLMTMQEDEVEDMSEFPIFTTPADDDDHHFICTHQDRYQYSFLEVASCAEGNNLGSNTNNENHRSVYNYNWEPIGRVAMDQKEFVTELGIIEYHWQPRNKHRRLRFKHSETGAEMEVDMSKLDLKMIRDAAKADVDDLQEGGRRNNPSSFVYDQNDREMEDDEDSNAKNEYEDDGFLVKEGSEDDNASEFSGEFSTAEASHNNNDDDDDGSIDHCDVCGKDGELIVCGAGEGDDEIGCSKAFHITCIGRTEVPAGDWICTQCAKQEDKLSLVVSLAATSENPNYGYEFPEFCSNVAIEGSDEDSDSDSSGDGNVKIVRPSKKSKMKVAKKKSKKSLKDSDSEDEIPPPKRKSKKGKAAVLDDSGSEEDTPPQPSKKSKANKKIHHLDDSSSDSDKEMADDSSPDAKPSKSKTQRRVIAEDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVT3</accession>
    <name>A0AAD2PVT3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS16612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVT3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="11">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1957228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="566" mass="62741" checksum="CFC7ECF515839F3B" modified="2024-05-29" version="1">MLVSFTIFNKGGMILYQHSDKDTQDQSQSSISDSINTFLSEVYLNPTRSRTDRKASIDGHPTNMIIEWEETSELIALALYPDIRREDFPWIQSLLAASLSEFQLFCQAQEQKRLQEEKTEEEIPMDESYPENMGLFDAAFRVLFKQHKSNPSAPTRNKTSNQKQQQQQQQQSKKGGKEKRHWHDGKAKVTKEAMAELDRSKTTSASDDNVNDADRDAVALAEARAAYLPTDADLAEFEIVPTSTLDDDADDESENSWGGSLKGLFQQVTGQKVLSKQDLQAPIQEIQKMLTSKNVASDIAEQVCQSMEDSLVGKKLNSMYRVKTAVRQALEKSINKLLLPSAQLDLLRRVVSKRDSLFGKRRPYVIVVCGINGVGKSTSLAKIAYFLKTNGCNPLLAACDTFRSGAVEQLSVHAKCLEVPIFHKGYSKDPSSVAKAAIEQATQDNNDVVLVDTAGRMQNNVPLMKALGKLANENQPDLTVFVGEALVGNDGIDQVRMFSQAVSSVNRNQKVNAILLTKFDTVSDKVGAALTMTHATNAPILFVGTGQKYHHLQKLSTQSVIQSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW06</accession>
    <name>A0AAD2PW06_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="707" mass="78956" checksum="FFEA63E5FA423C4C" modified="2024-05-29" version="1">MQHRRKQSLIVLLLRSLFVGQLFLIATKALSTLQKPFVSQVTAWLNDEGISWCPADVPVQFQSPSTAFLKLDSSSILLHLIPTPTSFNETLPPIFNKRLTDLVSATGCEKGYSKVIHLFQDVWIKKNEIVKARLSVQSGEGKQRRIFARKTTVQRINATFAMSFLEEHHLWGATRAKYYFGLFLECSGNNNCQELVAVATFSARRRVKRDGWTFKSHELLRYCAQRHAFVVGGISKLCKAFINDVKPDDIVTVVDRDWGNGSGWHSIGFHTVATMDPLAMIVNPNEPGLRRHIVGNWIQVDDLKTFSEANSNFRRLGLPREVLSKLNTTIDVAVIQKDLAKENFFPVYDTGVERLFWVINSTIPGSTQTLWQESEPKYATMYYSDNIGIMSLLRDAAAVSRPLDSLQSIKDVESWKASGVARSAKLIFSAPSSMDPDATVEVRERENGWRTVGIVGSKKNPSIYHSMYRVARNDQVEPDVIVSEFIKTMAVVALAGTHQEKDKKTTKFLHFGFGAGTLVRYLANKVQNSQHVALELDHGVVDAAKQLIPDCPNVSILSQDALQFVAEAVGQNVEPFDCVCIDVFDEDLKVPEEFYSPSFMTDLSDNLLSADGILVQNFHSGGKRRETILQNAARASSKVFPNSCFVFSLDSKPNGGNAVLFASHRPFNSNDGDDILQTLSHNAFLVQQKFGLSFDAVARVQNARRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW60</accession>
    <name>A0AAD2PW60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LRRK2 ARM repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="210"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="408"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="578" mass="64065" checksum="EA5DFE76917E5F86" modified="2024-05-29" version="1">MDKQITSCVNKLEKEQRDLKAKNIEVLGVRDINRQYELLSHLRALLQERLDRGDVSALSVSVGPSIVEVIRQNSKKEQLMEECTCILYFLSIFDPYFKKGVARLFKSLQDHPGNDSIQKASLAAIRNVVAANRDSLPRISPSIPVILDSMERYPDNVDLLSSSAEILENLASHTPSKAFFIECGALESLKTTMRKHLHLGPLQATILRAMSNLSFAAGVDIRSDMLPIISVVIASMRENPRDTKVQMYGLSTLQNISSATHVANPMHRSAEGLVVDTFHTILSIMKVHVEDASIQEEGMKALYRTMESAPDNRDLMIDEDGVVTIVDAMTRYSHALEIQSQGLAIMLALVTQNADNHELLFSTGGLDVLLAALITFPDNVNVSTYGIQILKDFTRLSLDFQRAVTAKGGISVIVTSMRKHAHNEDIQDPAFACMRNLCLHQDNREAVKKEGAITVSLTNMTHFKANPAIQAYGCDALGRLATIAMEDIFCNHGIEVALESMSEHPSHAGVQDRACFLLLALSEHRPALKHMKEYNVLPIVQAARVPPKEQAQERKSTLVGRLEGMDRPSLWGALSRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWA1</accession>
    <name>A0AAD2PWA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWA1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042235762" description="GOLD domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="25"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="336" mass="38768" checksum="7E8C85BBF6389A98" modified="2024-05-29" version="1">MIRSRLLLKLSWCLICLLESVASLPMEQTVPFKRMECFYDTFQEGERATMSIFVLSGSPLQATIRLEGPLAPLGADQNMQKFHESVMEFERNPNAKMTSDDFVYEQQVVDFESIEFEPLEEEEAVDQITGDDKHSEVMKVYERAKRRNEIAKRKRQAVRASDDPVLFTNGVPRAGWYRGCVVAHVDTVDVEFDLRKESDYGMHPSNDHVLSQDDYRRLQEDISSDAAQEKATAAMTKNGRRNVQQLQWQQGEMANDEDFVQAKEKIKELRSLLADIQSLMAKERRRVATHKQINEHSHQRMVKASFWETVLFVGITLMQVYLIHTWFTSGAPVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDC5</accession>
    <name>A0AAD2CDC5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDC5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="130" mass="14224" checksum="8C6404896FAF4624" modified="2024-05-29" version="1">MAGFLDKVKQAGKNVVDAGAKQMLKTDILFLDREIKNRKQVFGVEVYDLMAELETAESMSAEDKEAKIRNAFDSARKDIAVIEAKKECKKEEMTVLEAENGGGMATNNIPPSSGTVLNNSHPADADMDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDJ2</accession>
    <name>A0AAD2CDJ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDJ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="194" mass="22063" checksum="4539D5237ED63F90" modified="2024-05-29" version="1">MTNELPIGESKTTDETMGNSSEKKTAVSFSNIQIREYPIIVGDNPAIMTGTPITIDWEHVEEFDCSIDDYEQAKPKPRNMLELRLPARNRDEILKSQGFSLKDRQVGKKAANTTRRQRRRTSETMNLSIVQESIEKAKRAALNATIYRSRKQKEREFLKEFISKSPSVKPKTIASTDFTNDTVDFTTETVPEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDU2</accession>
    <name>A0AAD2CDU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1926160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDU2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1926160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1071" mass="120194" checksum="46EFBEE8F61E8A0E" modified="2024-05-29" version="1">MCIVDNASRSGGSVSQSTTTQTKSTDSKGTSPDNVGRSFRHETSSSSDSHFRTRNMIDVEMSQLGLYGRQTETETIRNCLDDLVKTGKNKLLYISGVSGSGKTALAATVADVVDSERGIFAIGKFDQKLRDEPYAGIATAGRHICGEILHRKNSTGKMRSGLSFDHIKKTIIENVGSELVTLAMILPEIEDIVGSVSDLFSEDSEHDEDYGANRERLNTAFRTFFRTVAAFFKPLVMVLDDVQWADLPSLNLMEVLITDDASTNFMLVALYRSNEVNDAHAVSKMIRSLDEKQKDCDFDTTKIEVGDLRVGQVDEILVDLLKLPSYRTSELAEIIHRRTGGNAFFVLNFISMLKSQKLVVYSKREQSWVWDESEVELETIATDNVVDLLKQRMKSLPAKMQETLELAACLGASFREDMLSKVARDYFAGQKDCPTADQISKWLTDGILQGLLKMDSVGYRWVHDKVQEAALSITDDADQKKMRYQVGNIMLRRLSRQELDQVLFVVVNLLNAGTGREMSSESAVSLAELNLRAANRAMRLSGFEVASHYTDTAIELLPTGYWKSHYEMAIKLHTIATNVYSVLGNVEKMEAMYDDVMKQPNVPLKDRLPLYSSMVESLSGRDVERAKDLSFDVLEQLGHGIMRDGKKLTMHLKLNLVKSHDRNLDPNIVSRLPMMTDENAIAAMKVLSPMISLTYATNKKELASVTSKMVALVNKYGVCSEAANAFGIRGAFSSNLKVIEAHAKCAHMIMDQSKDRYAKVATKVYIFCLFSFTRDIRWVQKTFFENYHYGLQVGDIQMSIYSYMMGLYYELMCGRSLVTVTEETRETMAHLKAMNRDSQMDLLSVLFQSMLNMKGEAEDPLVLKGEAMDETALDPASITSWNDALIIGYKGVLNAYCGSHQANAEEILEKMPFVRDEVGADAIIMWLDIYVAVSCLHCARSRGKRSGKYRKHGQNISKTVKTWIAQGCPNFLHLDYLLDAELAVLKGDFKKACKYYKLSIKIGEKMGRVNDAGLASERLGEYLLEKKDKGGARKALLRSIEFYKLWASDYKVESVRSMYEEVLRPASVIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGH2</accession>
    <name>A0AAD2CGH2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS3221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000254">
        <property type="protein sequence ID" value="CAJ1933236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGH2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1933236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="381" mass="41847" checksum="F7082D1265B376C1" modified="2024-05-29" version="1">MSAIHYAARDGDWNLVNSLLHKGVVDVDERGEALLEDSFDPEQVTALHISCDAGHLKISRLLLDRGADLNAKRDLIDLTPLHGACNQFDLAGMYLLLAYGADLEARWTHAIELGLIVQGSIVRNTGFVGSSVRLLVERGVEVNRFNTWYETPLNIACQHQNLEMMRLLLEGGANIEMTNDVDETHLHHVCEEGYLESARLLLDSGANLEAKNADDDTPLGYACGSGKGAVARLLVDRGANVNALSQDDTCTPLLHACRGGHVEIVQLLLDHHADIEAEDCAGHTALHVACEGYQASVADVRLLLDRRANIEARTPDGYTPLHIACQHTDMEIVRLLLGRGAAVQVRTAERGMTSLLLASEKRSHEVVWLLIRRFPWIIMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CGN6</accession>
    <name>A0AAD2CGN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DinB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CGN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473:SF1">
        <property type="entry name" value="DINB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22101" checksum="9AF88C35192F21FF" modified="2024-05-29" version="1">MPRASSTSIRALHGATLAMLQQKTGFINLLKNRFGAGQSKQLYQQVCPIVGASIGQHIRHSMDHMELAIRMAGEYPNINNDEFHYDLRTRGGNDENDIDAAFHRIDSLSDFLLEEKENEGSALVESRPVDAFFMLTGDPTEFKVSTTTERELAFSVHHAIHHMAMVKIIAVQSLEIGNDDLPPDFGRAPSTVAHDKGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHG6</accession>
    <name>A0AAD2CHG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000391">
        <property type="protein sequence ID" value="CAJ1934811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="193" mass="20862" checksum="F697EF8F13ACB028" modified="2024-05-29" version="1">MKDSITKPPEKEPKSITPVADQGQGGLEAKTGSNLTTQLSIALTKDNPALTRTPKSQSKQTPPSKIAEDGTTKGRLLLPPEIALTKDNPDPKAPKSQRKQPAPSFQNCREWCSARTTAHCLQQETQGVKVSQALQEGRLGKKEVFGNQAFAAWFSRTAKHTGLAFAKCVGLWADVNMKKPPSLNPTTKLLCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHX9</accession>
    <name>A0AAD2CHX9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000349">
        <property type="protein sequence ID" value="CAJ1934640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHX9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="128" mass="14173" checksum="6CF5566690CECBB8" modified="2024-05-29" version="1">MEGIPGKCHNFETTFSVDYQGSDSGTVAEALLSTVLTSMEEAINNSPNELKLLPISDTTYKQPNLWIRNSVELRNRISTYRALLTYCDMEYGNCPYAAANSKPIFIPAYVNWGEALGATLLPCSLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI56</accession>
    <name>A0AAD2CI56_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS1523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000058">
        <property type="protein sequence ID" value="CAJ1928668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI56"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1928668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="795" mass="90737" checksum="89722871EB1AFACC" modified="2024-05-29" version="1">MTNTIINYINYITTIIVNQEYIIQAGISFFRLPVRMPLIVTQTVRETIAAGLVCATALLLLWYMALDLYRSYQGLCEQRSCNRQQPPVSILRRPGGGSSHRKKNRSWFGVFTRKPNRVRFAKIFRRTFVPNKQELQSRRECWGLIQWRIQLHDKVIPEIENTVRFVPHTPVSILCPSRKDWGSPKPTSSNRVQFAPKTRRRNFIPDEEELKSRRQLIHQIDCKVKRRNAQRLMIDFKPTVLATIIEDPADEDLSDIDSSLDTGFIDGNVDSETIAIALENHRQLLRTVLDDMLSNIPVPMDLDDDGNIEPNDMQDEAPRLSLKRTATCSLVSSRPTKRRKLNSSTVPTSATEWAERINERFTPLLPVIIEDPEEEDIIMSTFDSSLDAGLIDDNSDSDVESFAKGDDEVFFPMNDEEQDWDSLEYVDCNSLEHAPPTSTPTTAPVSILRPTRKDWKSPRTTNRVSFTLTNRRRNFMPDPEDIQSRKNRIRDIYSQIRYHELCKCFEERVLPQLHSTVMAKGKAKRKAKKKAKKKVNRKIDFKPTLPVITEDPEEEDKNHFDSSLDAGLIDEDIDSEGPSFALALENHHQMLRTTVLPDMLSNIPVPMDLDDDDNVEPNDMQDEAPQLSLKRTATYCLVASRPTKRRKLNSSSVPTSATEWAKQINERFTPLLPVIFEDPEEEEEQDNFSDIESSLDAGLIDDGIDSAEDPLEDTIIDDNIPVPPPEESDNAATIDIPSDGMGSGWTESGKRYSLRRAKLLIPHAEDTFTEALGSGMTEQGRRYSRRVANRRNCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ98</accession>
    <name>A0AAD2CJ98_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000351">
        <property type="protein sequence ID" value="CAJ1934647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ98"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="229" mass="26126" checksum="73921DF2F3BACE0D" modified="2024-05-29" version="1">MTQPNIEASMCSEYTEYSDNLNDECTYDGYTSSFEETTRTTHVHFSEQVECKATISRSEITADEAIASWYTHQERAKLMVKYIKTVERRQSGKKPKKNSSYRGLETFDQCDALELQYTIEACVDAVLLEQHRQWTENIVDWEALARVSIECSEQSKALALAMAKSDKREAKKANRRMALMVEESMRSISSTSIESFQDMKKLVPHKASQQTALVMGSTISPVIELRSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLK3</accession>
    <name>A0AAD2CLK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000702">
        <property type="protein sequence ID" value="CAJ1938282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1938282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="92" mass="10525" checksum="A15C0DBF0A6EC11B" modified="2024-05-29" version="1">MIKAYENNFASWKRSGNHKEYAEKLAEGLSVQAAKLATQFKEYDNFAKNSKWLMYLHRKLETYGSDLLGKLCSKIPEELFRESTSGSTAMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CME0</accession>
    <name>A0AAD2CME0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000634">
        <property type="protein sequence ID" value="CAJ1937334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CME0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="352" mass="38843" checksum="195945A3C526691F" modified="2024-05-29" version="1" fragment="single">MPFFKRQLESSYGSPSRIRFSPEPKKNDTGQTEMAQPEMETTPSAIPAEDTQKVAQDNHPEPVVKIKDVEPRQEETLSAFEQELQKAHDSSPGLQALQALPGYENVFIEIVSSTAESVDENSEPTPVTDQEAQRMIDEIYKMAEDTDLEEEMLASISSEPITSQALNAIGSRKRKGRRRGEKSGQGGEEENKKGKVQETIIKATNRASTTNNRNQQTHANGTCSQALHQGLHSHAVQYASSRSHTVSFVEEMIEYEFDGVDDDITDAGDSSTVTKSVTEDSVQRMIGELQRMSEDGDTGNDSATSGSATITRDEMERMVAEIRLAAKQTASEPVKPKDLTENEAQQMVTDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMJ3</accession>
    <name>A0AAD2CMJ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000801">
        <property type="protein sequence ID" value="CAJ1939486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMJ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="179" mass="20061" checksum="09882705C975805B" modified="2024-05-29" version="1">MTGQLIESFEVESSASSLRDALLLVGVVEDSNSTMRQNSCWHPNHVCWPSILLRACTVGMALAGVMVFMLLISAFPTSTRSSSSVAWNEELQSQASPVALLPPYDDYDDDDEITAPAFLIGDISSSICHLWDNHGDLGLKPFGEEIDRTFCEKQQEEEGYDWLESLKYSEMLRCYNMTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN04</accession>
    <name>A0AAD2CN04_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN04"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="251" mass="28740" checksum="39E311CEDFFF427F" modified="2024-05-29" version="1">MNNPNRVHNPLYGNNQPSSSGVPPVGQPQPYPHQQPPHQQPHPHHYQQQQMQQPPLQQQSHQPPLQHVVHQSSHPQQQQQQHQQQHPSQLPQYQPKPQQPPPAQQPPSRQAQPQQPPQKPQSQPQPQQQQIQQLSQEERVLKLWSNMRYTVASSFEKSQTADAAAENKDKKEFQAQFTELSKNTLHFLTYRRDYHRLLSQIEAKLEGKAQERQALETYVRTAPRLGKRKRADVNEDSVAAAAIATAETGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CN47</accession>
    <name>A0AAD2CN47_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS1890</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CN47"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="16">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="143"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="294"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="507"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1930286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="704" mass="78423" checksum="E9D26C134BB66FE2" modified="2024-05-29" version="1">MNADLKREREQASFDVLKITHMFDGGKAATDRRRYLERVIERDPTDIFSNDDNHYLHRTERHVRATAKHVRLVEICRKLGIGKECGGELCESDDFYFLLDAVADDLPTALHWVMFLPNIKTLCDDEQQAKWLPLCRDWKVIGCYAQTELGHGSNVRALETTATFVPESKGGKKGGSFVIHSPSMTAAKFWPGTLGRTANHAMVIARLIDGEGVDRGIHNFIVPLRSMEDHSLLPGVKTGDIGPKIGYNNMDNGFAYFDNVEIPRRNMAMRFAEVDENGKYSKKHVSAAASKVAYITMMQVRAMIVMGSSKALAMATTINIRYSAVRKQGYNEDGKTEVQVLDYKQQQHRIFPLLAASYCFFFSGRKLWDNLKKIEHKLISKKPVTKVQVADIHATSSALKSFNTMVAADGIEECRKACGGHGFLASSGLPELMCSYLQSPTVEGDNHMLPQQVVKVLLKLVQAVQSGEGVDAYTTCDSYSLVPSLKALFSGQREKCLAVNKTDMKDLPTLLLAFRHRAAMLLINVAKQLNDDVMNGKSMQEAWNYALVAMAKSSKAYSLFLLLRNFMEGIMEEQRSKLLGRAEVSVLGDLARMFALYWMEKDIGDFIHDGYLTAKQASWVAPNVLEFLDAIRPNAVALADARDLSDFRLKSALGRYDGNVYPHILEAAYKDPLNSVDPGPAYDPELKRLITGGVGVYSGTASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNL7</accession>
    <name>A0AAD2CNL7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNL7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="482" mass="54427" checksum="185031C3A49B77C9" modified="2024-05-29" version="1">MAETIEESKDALLGMDPPSEDEDVELDYKCGELRMLSETFTAVDGDTASESTVSAESAGTRGNSGDNQNLQAVYGPPLSRDQAAAAVPEGEKGLVWYSIVIPDDFIVNGKLVSGLNKRDFDLSTHEIKPRRASLPVTRTQLFSALSRIEGSKGPRYIFNGVLNGWPGLRNFELVRLECKRSLGPLTTPDYLNSYQSTWGHHWSVVQEGAVGVAPQIKDKNRIYRATLRAAPWTREGWAPGNLGHVFWFEAQKEIPTLTYGSPMVATVGDEKCTAVHMISHRYYVAKESAKDKLTYHSVVLLEWEHGKFCTLVEGAYLNGIGGYKGKSNWYDDRDEPVTALYKALPKEMIQPWLSSASEIRLYDIASKNLDEFKQYIEKYAGSRFTDPRYTFSHPARLFYRSRSHIAQYLINYITRDGNYSEINRNCQTLAADLCSFLAGKKGVVPFHPVNRFEYNNRAHLFLYESQMYENKHKKTGMSRIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CP07</accession>
    <name>A0AAD2CP07_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CP07"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053159">
        <property type="entry name" value="Hybrid_Histidine_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43642:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="104"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1110" mass="126350" checksum="89714B33B6944D5D" modified="2024-05-29" version="1">MDHQTEDDYYGQTPQPIISQILVVHNDEDEKADDPRFEEDEALLSEVADAWLVKPVANESSKTDLMKNMKPSEIRQPKHKQQKLIVSPAGRRKRKLEFEFTGLIRREREVSLLKDCFRRMLGRPIDDGESETCSKEVVFLSGLSGVGKSTVAQTLEQDVEALEHGVFVRGNFDQTARDKPYSGIAKAFGMICEKIEQMPNAVVNRVATKISEEFGTTVEVLMHLIPELKYIIKDYSTTTFCTDTADHDIMNGLDSLRFAFRALTRALSAEFSPMVLVLDDLQWADISSLLIVDCLVTDTQNRNPLMVIGCYRSDEVDENSILVNKIHALREKTNKYTFNITELKVEAFSANDISDLIKSQISAGDKTMIDGLAALCEKRTMGNPHFVLEFLKMLKNTGLLVYDGDSETWTWDLAQIEEVTMSTANVVVLLQSKIQKVPKRVQRLLQYAACLGSSFSLPTLQLIWKKSNILDMRVSSEPLEQLLATAEENRFIEKCGPKRYRWVHDKVQEASLLPSKKPMATFQLDVGSSLYYCLDEKSLEEELFNVTDIVNSGNTKKRPEFARLNFRAAKKAKGIYAIQSAANYAAKGIELLQEGEVLTGHILTLQLYTIGAEMETALGNVKKAEQYAEEILKRPQYSAMDKMPFKVLSIRKGLVVDFKYDQTIERCLARLKELDYRLIWSRSTTSLQALVELKKAIRRAKHTKMFKETGYSLNKMTDQKYLLWMRLTGIFGYSAYQSRKSVLYVVGTCRNVQITLDHGIGPESGAIFASLGLLVVIFQGDFETAAKFAEMGLAMQKLHPAREGSCVYMSYSFVLCWKRPLQALLKPHYDGYVSATRMGDSTFSCWCLSAHHVWLPYMMGKPLRLILKEFSSLQSQMEELSQPGPLLFLKILWQMMVNLTSSFSNSHKLEGHTFSRNEVDDWERIGGTFVHFAEGELFLFLKPAEAADRAIAVGDKFSKLTPSFCLVMIETFHRGVALYIMARKTKQRKYKNHASKIRKTIKKWLRAGNPNVEHYSLLLDAEHAALSRAYASAEKLYEEAIVLASRMEYLHHAALFNERYADFLLNEVDDAERASHYLDEAIRLYEQWGATRKIEMLQSDLERSPAFQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQ45</accession>
    <name>A0AAD2CQ45_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQ45"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="731"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1039" mass="117314" checksum="C2724F111BDA71D6" modified="2024-05-29" version="1">MLDKRSVSGALFFVWIFVLIQPSRQFIVRFPDSATSRFSNVRKLYYSSELKEYLGSGDFNSTLPGDDVLMDAYNKWRMQFNKGEYSSERFENFKINYRTLMTANANAASERQAHEGRSQGFPSYMSLNEYGDCSIEEYKKIMASVGKFASQKNVNPTSSSTAPNQQATASYGPIGDPLEWDIDSGESEIDKEIRVEEARRNEEAKEYEIRLIYEAWCEEKGKPFDESRLPIFAEHYSNAVEYCAQTNKPLKLNEYADLTAEEYSSRKINKQQKEEKESAASFNWQRQSELSAPFKRQKEEKESASFNGQRQSGLSASFDGQQQQEHSAPSFGGQQQQKEPAVPFNGQQQQKYSAPSFGGQQHQKEPAIPFNGQQHQQQKYSAPSFGGQQQQKEPAVPFNGQQQQKYSAPSFGGQQQQKEPAVPFNGQQQQKYSAPSFDGQQQQEEPTVPFNEQQQTPADSKPPSQVPLHTGMSSNGSYLDSISKGKVLATYFGEKPELKGEDLDALFSKLNQAKEMEEETKIQARRAEVAALEAGEVARIKEEEQARLSAAEEARQQMLEESRLQAWEEARRQAEIEAKQRAQEASQGTSEIPSSPPAVAFRPLSGSYLGAVAKTWESRSEYLAQLEASTKYLESLQDTPPSELPRMYDELDALTGSLPIVANRAEAKKVVSSLNTVEDLWEDEMIENKFETPVNEPTEIKDDTATTVTEVTKIKDTTDSSTRRQREEVAARRAREEAEEWMRIQKQLEEQADLARERREREENALLEAQKRSKALKAANLERERRLKEFQAMERKTDDTEEIDRIKQLQENTERALREAAKLKQELENFNNSKYPSIMSFFRGNEGKPNLGAFKQNQQFAAAQRKRAEVLNRINTQDQKKNLFDWLQNPSAEKSKTLASVTMWSENKDGSITGIVEKSRSFDKGVRITTSPIIGKAYEGAVVVTASGNRYQLGEKETSSVGGTKAAEVFMGFVDGFQKTQKAALLFDWEVNKDGTLTGIVSKKKGFNDGVKITTSPVIDAIGPGRVVRTRGGSYYRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQV3</accession>
    <name>A0AAD2CQV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="450" mass="50902" checksum="1FF2636A8A10E339" modified="2024-05-29" version="1">MVLVKHLISPATLPKSPSVGPPILAEQISVLSYNILLPNSSDGWWNYKMYNPPLPKDLQYQSSWDYRKDLLKERIELVGADIVCFQEVSPDSFSSDFAFMLDLGYDGVELFKKGRFRPATFWKTSQWELGVPAAHKDRCLVTAFRRPNEEQQNNWIVCNCHLQAGKQGPRRVRQINEAVKGAMTMARKLKVPKPEEQIKLIVCGDFNGGSECGAVRLLEDGFIDETFVEDGVNVSSNLKKLPLSQPMVDVPSSVDRSSFADNHPPPTMVVSELMSNLMEEATYDDPILSNSMRERLERIYKKFSNSSGIMTKQEVEHWLETINLRLNRGDEFRSAAKHMGWVDPNPEDSYEVQKYRVQIPDDGVLTLEQFTDVYQQELSRGKFWGISHDMAVLGDPLPDDGVFEARYDRMYCSAALEPVAVLDTVSKVSCPNSNEPSDHLPVAATFKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRC2</accession>
    <name>A0AAD2CRC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS3666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1934258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="92" mass="10605" checksum="A967B62F20621761" modified="2024-05-29" version="1">MTKGTTSFGKRHNKSHTSCRRCGKVSFHIQKKTCSSCGYPSKKMRQYNWGQKAKGRRTVGTGRMRFQKTLTRRFKNGFREGTQAKKQTVKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRK3</accession>
    <name>A0AAD2CRK3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="259"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="579" mass="66301" checksum="C20607E9349DBEC9" modified="2024-05-29" version="1">MECGVWVGLSTLPGTGIGMFAGKDFRKGETLLDYGDHIIPIVDISSKFQNPKDIDRSEVSFLWTEYTWNADYFGMSRMGMDAVEVASAGFGAAANSFMDFVNVKEEDTAKYTVPDNIHRSRDPEAGAFTYHHSRGSFANDHIRAGQELFVSYGDKWFKGRKKLIGPVPITKDHVKAENLHVIFQHKLLNRRPKLKAILEEMWHIFVGDPEFNPWESSLLAALPEKDEYDLMEQIGLIELKRRKMVRSQEWLEEHAVCADNFYFGVSSIPKAGHGAFAKRKLKAGTAILPVPLIHIPDRSILEMYHPSGVREKNRQNKTSIPEKGQQLLVNYCLGHANSTMLLSPYGPAFNLINHNQTRVNVKLQWALPKRSNHFPEMLEKDPSYFSDIKSAKLAMEVVALRDIEPDEEILLDYGEEWEAAWQNHVQTWNPVPDAHDYVSAAEMNKRPERLRTEFEQIYDPYPSNLAIVFKESYEHNMGPYRDTKEIGHKNVKFSTGDSNKHTCEILSAKPLYKRTVYTAVLGIGGEGAEEMVLLENLPREAFEFQDRPHTEDLFLPNAFRHDIRIPDEMFPEAWKNNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRU6</accession>
    <name>A0AAD2CRU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS7297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000990">
        <property type="protein sequence ID" value="CAJ1940971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF109">
        <property type="entry name" value="3'-5' EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1417"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1435"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1463"/>
            <end position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1940971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1473" mass="167430" checksum="6805CBDC7D6258C8" modified="2024-05-29" version="1">MKRKSTSSQRPTLDGKHKEKISQGQKRAHAERLEASRQTNQATFMNSLYANVRRQQAEANAAEHSEQNPDGEGEDERNASIPIIDQPPELIERHEGMPIVPNLDILDDEEFVDEDLTEEEPELTIMHRYLQAIQKRLQYETSPKFPALENKWLNEFLGENDWWIHRHQYRSICRLLQIQYKEEENEAAYFRKVYVWLPDVRWGPSCMPTCAKCGSNTTVRNNGFRDNHFGRRVVALDHDYYCISRRYRCNNCEQKAREAKIAIQQSAAANNIAIQFTEETDSGQQYSFMAWNRKTLELYPHGIGQEFPAFLTHRSGVDRLLLDMMRPLFDKGLRPGAFADTILELHAKRYHQECLKHELELAKTANRYHRPMLSAFGDTSKYNGLVPTGSYLMYVYKLFHSTIKDFLDTEVKKRGAKMICVDASYKEPKHLCQYHGQNLFKGLITVTNEIGEIRLQFHVVTDDHEQFRPSLIAFLETVKAYGQNPLELVFTDNVQADRQFYLDTFPSLAEAQARLDRIVTGGNEESGDEQDNTCTVDDDQFFVISERGEMNRFVTALDEIMQDKSAEDQVVGLDAEWNVNIASYGMPKKIGKLALLILAYKDSDGRHKAALLRLHKFPSLPHRLLAFLVGGTKFVGNYVGGDIKRLGRDYHCEDEMKKVSVVNLGRYARDRDVVQSGTVRLDALVQICLGETMQKQASVRVSSKWEQPSLSQDQKKYAALDGIKSLEVYLYLRQKPDLSVRLSVEEARAGLCIDVAPLRGGALSMVATRCATGTLTEQTYDEWEVPSDMRLDTGQINKRRYRVVNVCSVVAPHYIVPYVKKKESGGPVCLDDFGAPPFFVILPLTMLKQHIESDTIRPFPNMNPNVNNMTGATGGAIPPAPIVPPAPPAPPRIMQNQLFDQNETFTEEDTGQIGTMDQLDGDAETAAVNLSNKDVEMLHKVCLLGDKAALGNDLLACAHLDNAPDKITDCFSAVVGDVFHLMDRMKIPTHHEFKKAFKVALRDSVLQWSPPELEEVKTAVKAKDGKTDDEIDADMYFNAAFWKACVPRRVLPPRLLYWRVRAVFVSFGGMIDSTSKKPLFNKTAWKKANNILKEILRGYYSDPPGYSFYSTKFNKRGEPMVNAYGFDILSCRRGTNDVESTHKLLLSIFGTWHIGLQMSDCLLRERRHRHNQRCSEKRRLGHPCIGHYDTWLIDALQILVQVNHGILLHPNWINSSDFKNTQEKFGTITLHDAELAEALAKVQIDESVRLTHDMQYLCSVMGTKLPLLPVHTIDERRHFSNLVVQLQNGQDKSCKKMALEWTKAVNGVTIFPKLPVHLRNYRDKFERNAKVRQAFKDAQESREILSTLNKALCPEIEADEGIDAEDTPQQLDNYTRQWPAICAPPQLLLPLAPSAVEPGNIHVGGVLINKAPDIAPLDRIKKRGRGQRGPDNPRKGARPKRRCMLCKGKGETDDAARNCPGSRHREDCKHLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTV2</accession>
    <name>A0AAD2CTV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubby C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTV2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="88199" checksum="2AC44FEA93535055" modified="2024-05-29" version="1">MNSGAQLHYDARRPGRKSRTFSASVTLDGLVTLNHAAPRPEKEAANNGVTGKLPNDFRSNGHGAFNGNQLYRANGVKQNDVKGIHRNLSNQRNITSEWRKSVKKTNPSNHSGSTQSSNSSERSSPQTGQATRGRSIEAKATTDIKELSSPPTKSTAAKHSGHRSPISRSEVFIEQVKADPNPTIRTLVKIEPTTATSPIKPNSLQNDPTSADSATEDMTTSIPVKSPPTTTDSVPTKPASQQNVPQIGGSATTDLTTGIQIKTKSTSSGVASKPTSPQHELATGDSATTYSQSVDSIDLSITSGVASKPTSPQHELATGDSSTTDSQSVESIDLSMTSLVAAKPTNGPTTGDSASVESIDLISISHRTKTSRPKSDHSPTRRTGNRTPTGKPKGFCTPVQMSNLLVVNQMNSDNDPSESNHDDDDLRILQNADGLKNSHSGSGDSMSTRRSSMGGSQRSFSFLVTTPSIPEEKAVIKPDKAFMNSSNMSVISDAESKVSRMSRMTIDPRITSDRRASFRMTREVNSFYEPTTNLEDAKRTMLINPSVIQASLVGGRKLPKPYKFKSKKQKAKEKRKLEKQEAKRRAIRARRYAEAEDMQPLSVSFPILTRPQDVFIHSRGKMGAGRTEVMITTEDPEDLVATLSYTELLPSDKGRRLASGRRVLRDAAGNQCALILHSRSIEGRNTFRICGPVPMNSLHKSVEGYFVWAEVKNIGELSSQFCMTLKRDADPQGQSIRFKTKNVGSNLLSCIGSEAHGFSIYRKKEDGTKTEGCAKISYYHASRGLTVSPNLDLGLMLCYALVIDEMVSNRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUX2</accession>
    <name>A0AAD2CUX2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001205">
        <property type="protein sequence ID" value="CAJ1944128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUX2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="104" mass="11613" checksum="C0FD73ED4711B4A7" modified="2024-05-29" version="1">MEHKVDFLMKRYTSVCPDVRSRVNAATSKLFDVTSDVYEFTSLHVIDNMGQAIATGPGPGLPAPFRAAATYFRIELRLVPRLCSLRTDIRIDPTKFPPSSNRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CVD5</accession>
    <name>A0AAD2CVD5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CVD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1937776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1068" mass="114271" checksum="94C738DC54EA6C88" modified="2024-05-29" version="1">MNTEQVSMNAEHQAVPQPLAVDYDAEAASQPALPPRSNDNDKTVYGAGPSKSNSRCTLVSLIFVLLAMVATGVVVWFVMDSKIQNQESRMQSDVQFQPSDDSSPSTLPPNPSPSTAPALEISDMKPLSMCMGDCDDDTDCGPGLMCFQRNQNTPVPGCSGGLEDNSNSDYCIPIKLPSLAIITDTNKLPLGLCEGDCDTNDDCADGLSCHQRSEFEFVPGCSGGSDDGSRTDYCAPSSLVPETYLMSLEDSTLFGNPDDNFGSSVSLSQTVVPRLMAVGAVDRGSTGYVNIYMQDGADDSWVFGATIEGDEIGSDFGHSVSMSWDGKYVAVGMPESKNGGRVKIFELSMTTTTTTNSNEIGWNQVGNDIAVGPPQEYGGYAVSLSEDGSILAVTERYSFHTFKRTNSGEWVVLGSRVDIGSFGGGSISLSGDGSRVAVNSQPYDVYPPDGFGNVYEFNGTEWTQVGQNLGDLSIFDSFGLDNIELTSTSLSGNGATVVVSCIDRTLENSYVRVYQDIGDSQWIPVGEPILGKLDEFAPASTVEISKDGAVVAVGDYELGRVRLYEFDTRPSQWILVGEVHAVNEDDQLGVALSLTGGRGDAYLAIGSPNKKHIVGNPGFVTTYKTTFGIRPDPTPAPSSAPTEWVEKADDPDAPIFAYSPEYVWSGENNRDSHAIAGLSVAMSSDGNVFAYGLSSDTVLNRVIVDGDDRVLRPELSGQQIGDEFGHSIALSNDGLIMAVGLPNSLVGTVEGSGRVQVYLYDPTGKAWSQMGDDIVPTVLQEYGRFGHSVSLSDNGDVLAIGAPMGNGVSIFRFDNNEWVKMGDDITVPETKAAWHGWSVSLSSDGLVVAVGGPTNEDNWDEAGACRIYEFVNNSNWQLRGQPILGEQRHGLLGTSVSLSGDGNIVAIGAINYELPEATANREEDVFHYGLKAGAAFVFEYSPDGNWNPRGKPIFGDAAFDRFGKSVSLTKDGKNLAVGAPEHGEGGQVRVFVFDEEHLYWDQVGDVQRYDSYDDEGKDGSYGTAVALTESVDGLRLLVGAPKTKARYGDRLGLLPKDVGEVCLYLTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWQ0</accession>
    <name>A0AAD2CWQ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="57991" checksum="4C30E868AC2DCA7B" modified="2024-05-29" version="1">MLRSTRCISQLEQRMRRLPIHPKSFQCHFSSVDAAKKEDDSGEDKKEFKKQPFVTAKLEPGEWDLQRTNPYFRPKPPRSRMISAEDFANRPPVGFENEFGSYEDSMVSLSWLDQKTSRKIYQIYVDMMVLSQQQHKTTSHEYVCRVIAQKFNITPTRAAAVIQLQHAEEQMRQHNPDMLCDDQAKYAEEAIQQNIRDAYKAQRAQIPKQPFVEDPVGAHGRGEPDETSVSWTSTDDIYDLEDKITQANVRDAEQARLIIDGHLYKEDVDDVQVQVKTDSTTKRLLKDKKKIADELEEASGSIPYPETNAKGEKRDRWKFVAKVVNTRAMRKKGRRVTKYTNNNVENTLVEHDGELRVATVAEAKQVAWKPTRTKGNEYIFEGAKKAWLEKTLEGKTGVWGRAPPTMASQSTKKAAEEKKEEEKVVEAASKEEASIDSKEEKKEDEKVEASDKDSSDSSDSGSDSASSSDSSDSSDSDSSDSDSDLEESKEKEEASPDDAVEEPGKEKKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CX76</accession>
    <name>A0AAD2CX76_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001546">
        <property type="protein sequence ID" value="CAJ1945846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CX76"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="392" mass="44693" checksum="BC0D2F8F2AEE46AA" modified="2024-05-29" version="1">MISRPKVVVLPVTDQVIQRVEAWAAAKGVTSMKFFDKKRDLETFQDGDQIAGVDDTEQGYLEEAFDQDYEPEDEDERDFNLRGQFDDIDDSEREELLADADNDVDDMPELTVRFQGDDDYESDDDSGDEGDEEEEPIVADLDHHQENVDRGTDDIGSLVTDLEDLQEPPEEEIVFEPEEPQVAKVTQSGQTYAQAAKSGLNLSQVPKKPREWPLSRSGSSANKNKNRVATRRKHQERELKPLKNELKSGICTKEGSCSTKESKAILEAQHNLCFQQIGNEMKADYEEYDATMIAHCMMQIKAKFDTDKGLNFIQQYYRNQGQKKFGDDGKDAVNKELRQMLLKDSFTPKFVKDMSASERKKAQSAMMFLSEKQFEKTIKGRLVFQGDGTYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CXM6</accession>
    <name>A0AAD2CXM6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001709">
        <property type="protein sequence ID" value="CAJ1946502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CXM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="105" mass="11990" checksum="342BFABC6C75DED3" modified="2024-05-29" version="1">MVAELGQYVHAIGTDSNNSMEPQSIKAIDIEPTKGQRTGHRVLNLNTKKMISRPKVVVLPVTDQVIQRVEAWAAAKGVTSMKFFEIWRHFKMAIKLQWMTRNKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CYT8</accession>
    <name>A0AAD2CYT8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10135</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS10140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CYT8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042440656" evidence="2">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1945998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="112" mass="10804" checksum="AFC471B0D1B503A5" modified="2024-05-29" version="1">MKSFSILIATLFAVAAKADNRLLQTAAPVAVPVAVVPVAVPVAAAGSSSGSSVKSASSSKSSSRRKLQTAAPVAVPVAVVPVAVVPVAAAGSSSSGSSVKSASSSKSSRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D0S7</accession>
    <name>A0AAD2D0S7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001528">
        <property type="protein sequence ID" value="CAJ1945811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D0S7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21397" checksum="C97667D1C21FF7A3" modified="2024-05-29" version="1">MRTSDVPGYDTRAHAVYECLKRDFVEKQLKSGALNDVVVTLISMSNTATVEINKKTLDDSLIHDLQRLSKRQPKLHGNYIPALDKALEITKADAENTSSLLFLFFSDGAPSDHQFMKCTHGINVFSKINQRNDRRNDRKMERTSRNQAWKCLTQSFRSRILQRGIDIFCFMRRDVRLGQMTYTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCC1</accession>
    <name>A0AAD2FCC1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1910562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCC1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041978336" evidence="5">
        <location>
            <begin position="22"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1910562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="477" mass="53585" checksum="D394F0C4858D29F3" modified="2024-05-29" version="1">MMICKKVSLLCLLAFVTNANAGFWSETEDNKEPKQPDEPVEYGVDVSFPIHHEEISTNYDWLPHNVDTSIQTPRQYQDMVRQPLGHRKEFYEKFLDSCVRHFGSKGQRCVVNEADRIAMSLRQPQSMQNYTEVGFKKIRAPEAVFKVIKEFWDKNKDKGKPEQWGVGNTYTNNWEAHSKMVSVEDTNLRGGGRGLKQKIWNAARDVIQEWTGEELTECSLYGIRIYPTGSVLATHVDRLPLVSSAIINVAQDVDEPWPLEVYGHDGKAYNVTMEPGDMVLYESHSVLHGRPFPLKGRFMANVFVHFEPVGHSLRHNAKETGGGDVDQKYRDALQRGSGGHESDLPPYVIPGTPEEEHWRQQHPGGHKSARRSSVTGSTFAHKAAQGGDLAALQREVAKKKEIIHAKDSNGWTPFHEAARGGHMDIAKYLLEQGADVNQRTNTDGGTALWWAKQELGTDHPMISLLESVGALEIGPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDT7</accession>
    <name>A0AAD2FDT7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS3663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDT7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007378">
        <property type="entry name" value="Tic22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33926">
        <property type="entry name" value="PROTEIN TIC 22, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33926:SF4">
        <property type="entry name" value="PROTEIN TIC 22, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04278">
        <property type="entry name" value="Tic22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042004488" evidence="4">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1934252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="342" mass="37196" checksum="6E07F03BA5291D6E" modified="2024-05-29" version="1">MNRFLSSILLLLSITSSVSASRHSFTRSVTKASLFGVRGGGLFGGKDDKNEAEVEQGEKKMYPAMSQEEIEDWMEHIPVFAVTDANGAGVILKPDEDTSVFYFFFNPLAANATLTQLQKVNEGMELKVSAFSLGKIWFKLLNADPNQEVLLKAPDSDDKKTATGIQYRLVPDTKDLLGARMLLTMSPEDSEALKTGETMTQEMAQKAIEKAMTESPKFKETYNEIPVFTIAQMRMQKQAAEGETGEPVTLLPMYFSLQNMVGTWQQFMSSAAPDMQGVEPAINLMSLHDLVAMMKKDSEIDFRNVVLVPAAPEGEGQSAAAGRPAGPANAMAGMGGATLGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEF5</accession>
    <name>A0AAD2FEF5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000435">
        <property type="protein sequence ID" value="CAJ1935000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="952" mass="107785" checksum="4C77E7029222AA5E" modified="2024-05-29" version="1">MGGIMMRDDDLFRSGDSVNNNNNNNIEAADETTMRTNQSSSPSSPSSSPSSLPSLPQPQAPSDTKTARRLSPQNFTFSNFDLFQHSVSNRQQQLLQKLSTNNNNTKKNKRRRNKKHHSPCLWGAFMAILLCQCILFLFQASISNYYHYHYHYHNDNDNDNDNDNSMEISHYGGVGLTLFLSKSSLSLSSSSYHNKIGNKNNIGMDTTNIDQTSGSTITIIHRPRLLIGLFSDYGSDGSGAHGGGGSNQPGSRISSGGGGSTNSNSKTYRNRHRKLFQLWNDTRLCPYNAFRQRQRQRQRRLLASKQDPNNHKSNLDLNDDDDYDDDECLILYTFVIGAHRRNTNNDDDNNNKEASSTSNSNSSNYNNNNGDEIPTLRLEGTRDEPLEIELGTASLSSNVNPNITAQISKNLPLDLIRHRDYTLLNIRENMNDGKSPSFFAWAHSEATSPRNTIEGHSMFSYAAKCDLDAMLRLDFVLQVLHRDLIWIPNHVTSPMNIPASTEQPAIVSSKDQALPNHATITTPLKTDPTSVGGIVLGCLRHKAMWADTTKDDFWRANYQNGMHLYLGGQFYIVSVNLIPGLVQEAQVQQLKHGMQSTGDNYMAGHEDHDVLSMIQAASIKNGQLVRWISMPRNYRFWEHPVKGEMWWKRIWKRESRKAAEGKLPSRNKYSLPVAPKGLPSLLIVLGAADPKDRVSYRDKLITEQHRGGKRICSLMDYRTADASTVRCDLVYTFVVGGNDKGPNEIVRGEDRIELDDFHKGEKDLLMLNIRDNTNSGMGQTVLFHLQNILESKLETSFDMVVFCNAQTVLSVEQWNRVQYQQTRSHRNLIVGDIRDKDQLPVEFGTERRNETYFFLEQENIHVYPGSDNACFAVSTNLVDNMLRHANESFGLSKGVKVIREDSSRKRKFKIFNPRAYFVQNLGYDLTTLAYMTPFTVLHWVPISKGQAPWYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEM6</accession>
    <name>A0AAD2FEM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000240">
        <property type="protein sequence ID" value="CAJ1933102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEM6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042038641" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1933102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45566" checksum="A3F0F2C14EF4699D" modified="2024-05-29" version="1">MRLSTMKYAIVTLLFALQLENICVSGSTGRPTGKKVRGSDHQNRNLVFFQQRKQVPSNYALKAGLKRARLTTTFSVPTTHPSAPSKAKSPTEAEAFTYSLGKNPSSPTPPSVWPPQTPVPSESPSSQPSRSPTRKPTPFPTLLPTPSPTKVPIKVPTDTLSYVGNNGNPSHEFPLAMCEGDCDSDNDCMDNLICRQRDGTESVPGCNGSGNNPGTDFCTDPSLSLTTQSSSGGFMLRLYWQSSYFWQETHAETWWCLECTKCDEFSLGDGPNHGCVVPGNNGGSCREGYTVWIRKCKDTRRHFKWDILKNSGSGDQVRARDSNLCLSTVSNRYVEMKQCDSGSSRQLFMPITDINKFELRPYHQRTWPRSSSKCLSQLHHPKDKELVGLHSCETARNHETIYWEEYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFP2</accession>
    <name>A0AAD2FFP2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFP2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042139024" evidence="2">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="113" mass="12080" checksum="A75EB5C65ED052A0" modified="2024-05-29" version="1">MNTTTFLLFALLLSVNTLLSVEAKSIQRKLTKKATKKAAVPTPPPTPAPTPFPTPAPTPPPTMMATVAATAAATVAAAGLDDDDMWDDDADDDLWDDDMWDDDADDDDWSSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG71</accession>
    <name>A0AAD2FG71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="11">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS1368</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="11">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="11"/>
    <dbReference type="EMBL" id="CAKOGP040000025">
        <property type="protein sequence ID" value="CAJ1927897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG71"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="149"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1927897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="236" mass="26134" checksum="EDDE2B5EA4638DA4" modified="2024-05-29" version="1">MNALRLSSRYAPRAFGLTRNVKSTPSLNSYRAFASGSGNVPVASGVPELHELGSVDTGFYDDRIDKVKEPERRAFAYMMLTTVRFAYASAARLLVVKCVASLSISASAAALATADFDLSEVEFGETITVKWRGKPIFIRRRKPEEIDEVRAVPMSHLRDQEADEDRVTNPEWIIVLAICPHLGCVPVSNAGEYNGWFCPCHGSHYDISGRIRKGPAPLNLEVPPYKFMDEKNLLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGR7</accession>
    <name>A0AAD2FGR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4461 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGR7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027989">
        <property type="entry name" value="DUF4461"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027986">
        <property type="entry name" value="TCAIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14688">
        <property type="entry name" value="DUF4461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4461" evidence="1">
        <location>
            <begin position="158"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1930499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="473" mass="53524" checksum="8B472BE166C96C24" modified="2024-05-29" version="1">MSQQALSRSTYVGNVRRAVLLRAHPDRFRSHGDDERRRRQETLLKELGARISESDFSDYTTYRKSQIPFRKGPSRFIPFALERRDGSILDDKLDINDSVEGILQSLANLLKKSGAVPPKPPPADEPVFNQDANIFDMPQFDAIDRRFDLNTAKGRNLLSFVDGLDSSEVERRRTSRLDAVAIASVARQMYSFQAIDGIRLGWSSQNFAVLVSSVVSLHEEHSKKFNVTSFYPLRLVFTPDEMRDPLDLHGGTIYLHPADTQLQWLNVLQEVTESKLLELEHNREMANQRTSLLQNALGVKVVKGYSCSSREYHIFLAKMAESLSETLDSTNDESTALQVESLRVVVESPSASRRIRLTEEGYIRGNSAMSESDLRKAIARLAHDAQDRMKQEKEYTEKCKEMTRQIQYSLGLQRVFRKGVVSRKEFLISLGRLLEQSSNLGNSLSGFSLGIGTSGVFAHLSDDGSLIVPYDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGT5</accession>
    <name>A0AAD2FGT5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGT5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="368" mass="42011" checksum="1427B0DDFF6B92D9" modified="2024-05-29" version="1">MLIHSFFTLELDTTEIIMNNEVKPPEESDFPRMHLAVQVGDNHIESPFHYSSNELTIAFVNPYTKDEFHDDLQFVMEVEGPAEFVDGGAIGCDGNKRLSARMQDASHGVQLKVNDMTSTLRLWAGWATGQESVRLTENLMLEPHHTPTGGSAEQQQQQQQRDLKDEVVAEEGNSEPGNHLPNGEAPDDLAAGNGLENSEPENPVFNEEEAANEEETNREIPNKDPSGKLDKIQQIKEQIKRFQDNPEDSLQKGDESYREEDNASGSEKKKAFHLDEIKEIMRKTHSHPVHHAMHLHKKVSDIGKKIHDKYLYDEEKQQSFRQQYESDEFAGRLDTQRHIFGSIFFLATMGYILVTYTRRRGTKGRRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIM5</accession>
    <name>A0AAD2FIM5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001057">
        <property type="protein sequence ID" value="CAJ1941682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1941682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="375" mass="40898" checksum="9B9E4F7240DCAC8C" modified="2024-05-29" version="1">MSTTQSGTNSTPAPTAGAANQPVSPATPTVGNTAGTPANATVPPGFTLASLEFAVTTLFREPLDSPLMLALRRDGSNCLMNLLFFSEDEVRELKYDAPLIDKHGADTGRTELVQLERPHRGTFRVLLGYAYLRQTVHCDPITPINCMNIDVQAFLNYQCSGDFIVFNNTTLPQPLVSKPGHRKPIDSSPDTLLPTQMETNPGSHLATIRNEFAPKHGELQRPMSDKSDRQATVDVISNQYSDTTSPTTLVSSALQPSICTSDGVNILNGSRATQLVGAQSTISRPTLNKRDIANDVIFDSNLEWDQTLLDPNIDRLDEQGKVVIFALVSLPTALATACSFSCGKRAWGVILMLFFLNKMRLTSTQWIWRMGSNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJQ7</accession>
    <name>A0AAD2FJQ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001158">
        <property type="protein sequence ID" value="CAJ1943900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="274" mass="31757" checksum="72BC0E62F3C88CCE" modified="2024-05-29" version="1">MLMATESFIAPEEPTKKKNVWFEWNEECEESDYEDEETADEVIVHTIVEDPNDKVHKHRNFLHDDFFDNFIANFGQNDCDAKNDKTFHATKPTSEYAFVREEIDIKRYSDIDGQGTYDSDGDEIPQLVERKMNAKHYASDKWDHDHGMPKYEYDSDNSGNDDIPLFLVNQHGVLIARRQYNSNDDDSDDDDEDSTHNKDDPYFYDDDGDDKSTVQTETSIQGEITLTLNGIAMANMDNWKSEEMKLTPQTWFGDSAASTHMCNDNTNLYDYDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL87</accession>
    <name>A0AAD2FL87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000835">
        <property type="protein sequence ID" value="CAJ1939721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL87"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="527" mass="56903" checksum="0364D1EAF8D8B97E" modified="2024-05-29" version="1">MSNRILFHLTTMRKLHLSAHFKTTNVVAREKPNSCRILFNVIVVLFGMAATGVAVWFVMDSRIQSRPKVQPTESDRFTSSASLQAVAPQSTDPPLEIVDMKPLSMCMGDCDKDSDCARGLMCFQRNANTLVPGCSGGLEDSSRSDYCIPVELPPLAVTETFPLGLCEGDCDSNDDCKHGLICYQRTGFVPVPGCAGGSADSSRTDYCVPRDLVPETYMSYLGEKLFGNPDDNFGSAVSLSQSEPLLMAVGAVDRGSTGYVNIYQLEGGDSWVLAATIQGNEVGSDFGDSVSMSWDGKYVAVGMPESNNGGRVKVFELSTTNSNDIGWNQVGNDIAVGSPQEYGGYAVSLSEDGSILAVAEPYSFSTFKRANSGQWVLLGSRVDIGSFGGDSISLSGDGSRVAVNVKPDDVYPPDGYGRVFEFDGTEWTQVGQTLGDLSIGDSFGLDNIYLTSTSLPGDGTTVVMSCIDRVAEDSYVQVYRDMGDSEWIQMGDPTLGKLDEGKLDEMSKHHLDCILRFQNMRREIVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLM2</accession>
    <name>A0AAD2FLM2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001079">
        <property type="protein sequence ID" value="CAJ1941796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLM2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="112" mass="12627" checksum="C34CC12AB6B3E99C" modified="2024-05-29" version="1">MYGKIGHIMVNCWQDEGNATQRQNGSRRRSKMRRKMGAIAKIPVTQTDKLIKGEPQGMLNCHEVFELLNDPNIWIADTGALVDTIPYLDKLENVEKLEDGKGNETLMEGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLQ4</accession>
    <name>A0AAD2FLQ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="474" mass="54480" checksum="6338A542B9138255" modified="2024-05-29" version="1">MKAVYRNNIIKRMGGDAGFDFLVSTYSENIHDDARLDRFFGNFDLNTLTCLQKELILVAFLEPNEETEPRKKRLVFRNDMMGMDRSIFPVLEEHFVDALEDCFIAGLDFELSKAYFSELRALFKECANVSKYRENIVERMGGEATFEFFLVSYCERLEEDHRLHHYFKDLDSKSMTRLQKELLLMAFLQPTSDNDFKTLTRRVSSKFSALFALGMNEEHFEMMESHFSASLYDCLSREDVIQSCLRLFANLMTFFQDNSLSVTNDVEEDEGSITGFDEESVTEFDEDEEYDMMSESGHSEADSVLSPMPPFPRERAPSYVTKRIQDALSQSERSTCSISIRSVETTRTISSFENRQTQGNTSYVSRRIQEALEKSDRSSGSNSVHSMPHEKNECASCLPKRIEYGSDRFFDPLKDSQRTEATVSSVASEDGKAGTRISPIVLSKRSKGKPKMMFSWKKPAFRSSNKKTAVHNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMA5</accession>
    <name>A0AAD2FMA5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FMA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="455" mass="53511" checksum="9F70671A4E9C9330" modified="2024-05-29" version="1">MAQPRKLVRPRSNNRIYQQETSHAAVGGDEHDNDSKSKSTSNSNSNSNSTHQHHIKSGNLDVDDKKGKKHEFFFSKHEDKVDRWLEILFRAMRNRQLQRKVLLLAIGIFLFLQIRITIIRYRRRHPIRRVMYADPDLTLEQQQQAAAAIASSSSSFSLSSWLRGSTAATKEEEKLKLKRQNTKPDVCFVTSSYAKDNSNMDNLVRVTNGSPYLRFYIFTNLQDSQWNTPGWEKIITNFTYRRKITHSRYGKFLGWKYPQLQECRAVVYMDSCIRPTQRQSIWRKLASKLESNEVGLMQNLNPKNRSGIFGEFLAIQKSQKDMTTNIVNSLRWMVNQPDFDENIPIYWNEQFAYSPKSKIYQRLSQDFWDRYSKEEDSWRDQPLWAFMMHRHNVTPMSWPEEEVLWGRSRVDYGHNAHEYYSENDVLADWIYAPETEPPIASVLGMEKDASTEGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNX5</accession>
    <name>A0AAD2FNX5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNX5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="987" mass="109916" checksum="89B5F191980381A2" modified="2024-05-29" version="1">MTQEDNEQKGGVTKEEESPSKKQKEDDGEGKPKEAKKKRTSSKSKRKSSKGDAGSDKEQSRKQAILQKHKELMSTTDESKPRKSKSKSSSKRESKVDQDGAVLVEKKRRSSKSKDSKRHSSSKVDPNGTIAVSKRKSSSKSKESKSKRSSTSAEPTKRKSRTHSPKRNSGTELSGKAHKTDDAPKKQSSKPSKRRSSTKEGKVNEGDSEGHPKNNDTPKPPTIKEATEEGEEGTKKKEDMPTWGSLLNKSVENDSKKDDGKETSKEATQKTEVKKEVKPTPAFGFLMGSRSTSIEKEDLKAKESAPKPTPVVKQPDLKKERSNQSLAFGMLAVMMGGSKRDIVKPPPSEESPPTSLEIGSKKDDDINETANTPVFQMLESERAPPPTAPKQDSKKPIPTPPTVPQNDSKKESSNQMLGLGLLQSIIGGSKRDVKPLQTPSPPSPTSVEEGLKQDDDDINETSKTPIVEGPAVAKQDPKKEASNQSLALGMLAAMMGGSKRDIVKPSPPPNTESPTPLEDGLKKDEKDLEGGLKQDEKDIHETSKAPILTTNPPPPPVRSVQKDPSPAPSDQKDLSPVRMVTKDHSLEKKQHHGRHHGKHHHSKHHHKQHSKGNATLKTVELMESPTNSSVEDTLNTTMDSDSQEKMFAGMKNNKGKKDGERHKKAGPSRVKQICCIFVSLILILGGLATWYFWDELNELVTKSEVAAVMIESPAPSLSMSPSIAPTISMMPSDLPSIVPSSNPTLSAEPTILPSEKPSNSMAPSANPSLSQFPSFVPSIEPSTSMEPTALPSMVPSIEPSVSQNPTWTRYRRDWDFKVRLQWQKSYFWQEENTERFWCLECTKCDEYGRGDGWEHGCRSYGSGDNRNCRAGDSLWIRDCRSRGNRFNVLQIDQKSYMLRLDNTNLCIERRNKHLMFRDCNENDIDQQFVPWYDWNKFELRPLAMEGWGEREADCVSQLHHPKQDEVVGMHNCRLSRIYETRHWERYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ48</accession>
    <name>A0AAD2FQ48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS11907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ48"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="31"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="825" mass="92900" checksum="7603C790EDE78DD8" modified="2024-05-29" version="1">MLRRIRGNGGLYKDLLNKEPHVVSITFWREEFPFQKDDTEDVHEPTKLGIMIDKAPAEEDGDRTGGDFQITDIQDNPDSLLYGMPIEVGDRLVAVNSQPCYGLDIEMLKQMIATQTGIVTLTLRKTRMAPFQDELRLAVFIDSQKHTCIPMDICLFKEEEKLSIFALYDHFDMDIKSNANKNKNDWLEKSCLAEGQVLLSVNDTPTFQLEEDDAHSIMNETLNTDEVLAIKTYFPSRASANEAPDMADRVTSYIVQLEHRMTRSLAQARNENDDLNFSALPYPVFSSAAQLDKTLRGAYNRCITISTGKPLFRLYLVMEDVWAKYAKVLIRRFPKDSRFSKVWRKRLGNEKAKYAKHENMEGCPSATQLDVNGAEKNEVNDETATEAMANVDSEDEDDLNSVPTFESVETDSEDKNDNAANKETASSGRGWFFSRRRQQSEHNPEKNIDQNKAGSSSDDEGEQEKTEPDIIQKQNLAPNQSRSWFFSSKNAADESKSLDGEDIATDSNQRSRSGQLDSKRCEPKDKEINIRAEICHVICTGSYCLDLLTEREIALNETIEEGFKVDFGETKKVFQEEVIQKGILQLVDSVNFQSEPIFASMARIRWHRCDEVGDTSPYAMEVVDLLKKRITSLIVQLPPQYHHKFKYDLIEVICQAFYNSLARINRISPVGTQQLLLDVCTLKLEFVALLKISEPSKDVEVDSDFADARMTDPQRFVNELLKRPEALLKLAGTNVGVDELLGTLNGNPAAGGEKGEKPSPNGDSVEAESGSNIAKTNLGESEDGNANEDDETTIVFDHLEDLDTTLETPAFPASFDLDDEEPDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ51</accession>
    <name>A0AAD2FQ51_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS11939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ51"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="97"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1949127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="311" mass="34281" checksum="F4C1F6BDB8D99E75" modified="2024-05-29" version="1">MQALIPIVLNAEEQGNSPTPARLSENTSNTTSSMAEKTKAKAVDPANLSAQEAKAVAEATASADRSFTPSPALLNSKSPTALLDQVDGPSLVNYSDTESVYVGSSVPISAGGSLTVPIQVNTPGSIVEYAAENKYHDIGFGITAEREEGITVVQEMSRCDASEVPMLGKFLVGTVPCLLQFKFDNEYSWMREKVVTYKVTITPPSKETLISGRRRRAEACKRAVEEDLKSADDRLNKAQDQKASVQKELEELKRQLELKQKSLKVVETEEKWLKERVALRKDQHKLLQQRMDQGWDDEADVKTAKQAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQH2</accession>
    <name>A0AAD2FQH2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQH2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="130"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="201"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="279"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="366"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="444"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="517"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="595"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="667"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="850" mass="97427" checksum="34070A7DD05BF379" modified="2024-05-29" version="1">MIRIQVFDPRGKKVEVDVDPNSSIKDVMAQVETETGLEKETQRFTIHGDRNVFLEPMKIYIRDSKGSKFLIDNVEPLDSIDDIKKRLEAQENIPADDQYLLFGETPLNDGTKKLFDYGIKHRAWLDLEPMKINIKTTKGEVFELVVDPNDTVADVKKQINETKKIPLDEIILTFNGESIKDESKLSECGVRHRDTLNLEKIKIHVKNGTNRGKGKVHTFEFEPTDKVEAIKKIIASSSKIGIPVQEQLLFFQGEMLVEPGKTLRECNLKHESTVDLEQMKIKVSTFNGDKFKMDVEQTDTIEDIKEKIMEKKGIPMKDQILLFNGKKLPLKGDVESPTGEQLKDIDMTLFDCGIHHLDKLVVEEHMKVLVQDDTKEGGGKVYTLYTEETYPISRVMDMIADEVGMPKEKQLLSYEERFIIEKDVATTLKDYGIKHKTTIHLVPMIVNIKTFQGDTFPLAVEPTDTVQSIKDRITEMKEIPLKDQIILFNDERLNDPNKSLADCGIQHLDTMTVEEHMKVFVQDDTKNGGGKVYTFYTEETFSISKITDMIAEEVGIPQKKQLLSYADSLIFDKDLGTTLKDYGIKHKSTIFLVQMMINVKTFQGDAFMMTVDPSDKCRRIKTKVKDVKDIPLNDQILIFNDQRVSDMDSMKDCGIKHGDTVFINQAMKVNIQDDTRGANEKVYTFYMEENDTIHMVAMLIQNKIGIEKDKQRMTFKDEKLEEEDKSLKDCGIKHDDTIHVKKSYIPVDWKKTVEEKYGKVKVTTYNVDYTLDKGVIAGIKGEKEVTIDVTGRRRSEMADQQKEFMAERAKSPKKSPKKGRRSMKEFLDDVAVSKEKLAELEKADLEKEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FR02</accession>
    <name>A0AAD2FR02_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS12488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FR02"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF30">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1950233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37946" checksum="4A905D56ACB9E999" modified="2024-05-29" version="1">MNMEDIILEYVCPSMGCIMANAMNAAPISDLRQALTVGTLGDLNPSPWVFMTGNCLGLCAYSYYTNDPFILAANLPGLLLSLWLNHGAIKLQYLELRTRAGGGGGGDNLLNNHNNNNIGGDDEEALDLQDDSIIHGVSTSNNQRTMDEQRLIPPEAMIFVSQEVKLYRILLVWSSVLIWVGWISPLLRTINSSIFLTRISSGTAPEIVGLGVNMNLIFFYGAPLTSIFQVVKTRRSSSIHRPTMYMSFMNATFWTGYGFARMDPFIIVPNGVGMILGIVQFTLCRMFPKGEGDRIPIRGESFDDDGLMMTKVNTGHDDYNDNDSKDNQTGGDVELDDDDLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRW9</accession>
    <name>A0AAD2FRW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001777">
        <property type="protein sequence ID" value="CAJ1951030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRW9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="127" mass="13811" checksum="D8258CB53456FF13" modified="2024-05-29" version="1" fragment="single">SGAEEDEDVPVGYQLIELMTVLDVKMDLTRKARICARGDQTDPPMSATYASVVTRESIRLAFVIAALNGLNVLSADVSGAYLNAKCAEKVYCILGKEFGEYAEKKAILVKAVYGLKSSRFAWRSVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTU2</accession>
    <name>A0AAD2FTU2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS14099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTU2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="407" mass="45916" checksum="7DD113744DD74DC1" modified="2024-05-29" version="1">MATASELEESTPPKTQSTTKKIAEVLISIAPPCSNKDEALAAYVSTTGYQDAFHSVSLRDTSKGIYHLVPVEAFLYPTTHLTEKDGSVILHSDTTVHDRLNDEEYAMTDNEIRKVILRLAGRITPDDFADEMIEKARRAGDTVKYFRKRRMSINKDLIVAMEEVALEAIGEVLVQMQLQFDKTKESEEELPYDEQTKREEPQLLPGPTNATSAELLSARALIKTPVVSLFVPQCIFRGGGLDKAQEILSKLLEKELSSVPLAWENMNSRPSEYADILEAAEKAKRPVKFIAWGSQWMPRVDRKDLLKRNIQRFRQTGRYIPAGAIGGSLDRIESLRENAEEVAKFLAKGDEDWEKYMDAAFARLAGFKMQSDGTVVKVADCRTLLPPFHRHKRSRQFRGKREHSGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUV9</accession>
    <name>A0AAD2FUV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent transporter ycf16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS14533</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="738"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="785"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="861"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="972"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="125"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="447"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="744"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1065"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1953935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1323" mass="146146" checksum="4DA92619646188CD" modified="2024-05-29" version="1">MMKDSNGIQDETSSPASAAQHESPTKSPDSPDSPKSPHPPNLFGKASPLAKLLFSWPFSLLKIGLERPLTELDLPEILQVDSSKYQRNYVEDLWEKEKERCPEQPSLRRALLIDYFKSTWKAQPLLCLQFTSTVVQAVALGNLIESFETGNGEGYVWASVLVASGLIVLLDLHQVFFIVWRKGMQVRISCVGAIYAKSLRLPSTHKDTNANTGRIMNLASNDVDRFLLAALFINYLIWAPLQSIGILVVGWWIMGPAFAAGFALLLFVFMPFQVYLSNKFAFFRSKIAAITDRRVTFVSQAVHGARIMKMSGFEWRFLERIQDIRKEEVDQIQKANRLKAANEALFFATNVVIAMAIFLVHVLLLDGTLYPRDIFTVFTLVNILQLQMTKHVSLGIMGASEAYVSIGRIQEFLESPEQHFTESTHDTLQNEQIAISMEDVCCQWNHVRDISTKKVTDDDDDDEISTASLAAALTDITIDFEKGQLTCIIGTVGSGKSALLQAIVGELPVFTGKLQRSYDKLAYAAQDPWIMDGTVQDNITMGSPFRREWYDQVIDACGLRLDFSQFANGDQTVVGDRGVQCSGGQRARIGLARALYRDADVLVADDPLSAVDAKVGRQLFNKAIMELSVKRGKCVILTTHQHQYVHEQRCVLVTKGKIGKIGSYAECVATAGGKLTAHSADDAVDSLSTDPKTASFKAGGKNEVDEIAPSTSVKVNESKEDSNTGVVKFETFLNYARAMGGLGIGIGLFILFTITQAVVLLAVVMMGRWAERTPEDQKSWDILSIVIAMGVAVILLASIRAVVSFYYTIKASRTLHDGMTKAVLRAPISFFDTNPLGRVLNRFSADVGSNDDMLPQTLLDFTVIFFMVMGTLVITVTVLPFTLLAMPVLFYYFWSVRKVFVTSTRELKRLEGLARSPMFAMLSESLSGVATIRANDSSAHFVKKFEFAHDAHTRSFFSFIAASRWVGFRMDSIMFILASVVSVLAVLFERQEWFEVDPAILGLSISMLLQLSGLFQWCIRQSAEVVNQMVSVERVLAFKNLEPEAPLEMDSDRNLDAAWPHQGKIEVSDVGIRYRKGLPLALNGASFSIPAGARVGIVGRTGSGKSTVVQTLFRLLEAENGSITIDGADISKVGLHRLRTKISVIPQMPTLFSGCTIRENLDLFGIHDEKAIVKALEDSHLSDAIEQLPEGYDTLVAEGGSNFSVGQRQLLCLARAILSKNKILILDEATAAVDRRTDQLLHESLHESFEDSTIIAVAHRLDTIIDHDYVLVLGLGKVLEFGPPAELIRSGGSFSQMVEETGDRMSANLKQRAFAKESEIANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUZ3</accession>
    <name>A0AAD2FUZ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUZ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1120" mass="125358" checksum="604B4AA8E45ED505" modified="2024-05-29" version="1">MGNDDIGIQQKSDYNQKNRAYKQLKEQQQVVEDAIEHLALMHCQDLNGSVVQVGRVARQFDDAVSQVRHLRKQVKEIQETLGAGNAPSSKEQANASAAAASAMSLRELWMKKLEAEAVLALLDKLDRIRAAPLQFDAYLQQHRIGAATIVVAQALDTMFSSDVSQVQALHKIMEQLMMRKQKAEEVVWELLMDVVFLRTGNGKAELLSFGAGRKALENELGKDGDIRRTSAKPVDLFNHSNHGMVNPFLGYSMRFALDYDLQMESLQNPLYLQEINDDAIVEEDFYDDEEDGSVKKASRFVIPQPAMEAEFELESEERRSIDELKYHGGADTKALSRPRYMDHILALRTLVECLVRLRRLDDVERNITEVVERELTALIHREQTRTFLRVEGSTTHNLQRRGRYAMLMSKAGATTDLRDFRKHMASIVSAFGNVQVRLTHLSQIIRHRIKAGNAYSSSSDSSIVMAGVLQHAKGVMERQLKMFHNACLTEVADSPEDSKFSMSSGQSRRKSTVQAKGKNNRSSEVGIVRMGIIDDEEEGTEDTSTWLAPTTSSRLMNNQNLSIPKFIKDVLFAKTTQNGTPQIRHALFFRKALAKWHRDNALLRKELADSTREDTSSPSYSTPVELPALEYLDNVIQKAVLPVLQEEAVNGTVQALERPDAFDPVLDRNVYARADSNEPQDVDMCVACTALYNFTGPLFLALHRLPKGGDMYLPLVAVLEHVILTFISRVKQQVTRICSNQTALQLLMDSSSQYREDSAPKSFGQAMERRKAFAQLVLAYADGDLLEAMSDDRSPGDLSGVSAIPPPIGDTPRVVSDPRAAVLADYGELDFVGGVDREEVNLSIELQFLKPYLEFAGMEENNTVKTCRDEDLMKAACLAHSLLKLSSLLDSRLKMRSQFGVTTKTLANTRALREAIKTIRSNGLKMAKFCRSDVLLQSIVRLAKVCNSSTIVARDAVRIPSSVNDLGEYMTAASDNLREAAGNAVTAYTFSTLEQYIPLCLIQTVRVLAAGQGIVTKAPLTMNGVEALDRSGSVLYRDLKGATSFDNSFWDIELAAVSFERSATFFGMMELEMGELEAYYQDNRNDFSEQDFQLMFTMDGPKRKGDVNRYHTLFKKMERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FW79</accession>
    <name>A0AAD2FW79_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1533" mass="165389" checksum="9F0CCAB347A873B9" modified="2024-05-29" version="1">MSFSVRNRAAMFEKPGRVDTEAEVVTIPATKVVASPVSPAKSAVSSISYKSANSAASPLGAGPYKSYRNNQRKGEGSPRTKSRSTTPNRSSRSSAEQGSTTPKRATASQRLSTSPRPVSPHKSSRQQRSASPSPRGSTVSTRVSSPQKMTVQQRSASPSPRGSGSTVSTRVSSPQKSTMQQRSASPSPRESGSTTSTRVSSPRKSTTQQRSASPSVRGSTVSPRESSPRKSLSPRKKPQIKPTGKIVSPFLSTNDVSSKPVVLPLKSPTKPRGWGTDGLKSSGLVSQSPFRNASRSHSRDVTESRDTSSNSWSKKNVSAEQRDSVEQRDESSLKNSLDAASVVMEEEKSQTGSSNASSRSSLSAKELGDVAKRALDIGKRKTQKSKPVPGPNQASSPSSKLSGTPSYLNNSSNQRSASPYKGRTTTPSIITKEDDVSASWGAHLKSVSPAKVSSPHKSPAADATWLSKSASPSAGSAKEDDNKSIASASWGANLKSVSPAKVSSPHKSPAPNTAWLSKAASPSNSGQMASSSPKASPAKSWQVTTVQPSSPRFAPQSSPKSPKKFLQPSSPRRTPVSSPKADVKSASPVTSAVSSTANGRVKSRAAAVAAARKNRTAAKGTNSAEARRAILASTMQQKEKKGEISKLSDDVEDVSARLGMKASRVLAMKNSQSKSDHNRGDEIGSSVSVESGSRSRRFDHPAFASRGYAKNSNNKDAEKPFSTELMSSFRHFSAARTDTEKTQQQKSKVAKVDSFGFPEQEESMHSTNVGFTPRNEDNIYLNNFSMMSSMHEQMTPSNTGMRTTRSNHSMAQSMISTTPTGHRKPTGELDYMLKTPSVSQRSTLEATEGNTAFDSKSVHSVATGKITNSPPGFVLKEGGEKHVVGTTANANDEFIDQFFNDFDADAPSPKDSTAGTDVSEPLAMEALNLPEDANGEVGDGANDTSSSKRSVNTSIRTGLSSIQNDLTQDNGSKSMRSGLSGVFPENNSQHKPTNATKPLPDTIREEEEREVLSAMASQAGTQTREGDRDTLFDGASFQSKTLKDGQNDTLFEGVSHASSHKSGSWWKGKKVKTSLKNALSKKSPRNANPVEDDIFGDLEEDNNAAQKKRSRTKTPQSTKMERQTKQVTPKSTKVHDRSGTKLELEENTDVESEITTSILGDGKKVMVDRLLTARNETRSAHTRSADSPSTKDKSTSEKSVSNHSRHNRTASIFLNLGCGLGEMLDGTFCNYPTTQTPTSKRGDEKSESQTDTCNLSVKEEQIWKEWENRDESESNGSHTRSDGKSSVNGVSQLHGNDLSTLSAREDTDATSQPMREGSESATGQLVDSDEAMAEAKQAAKREETRHSRYSALSASTPMALSNNQRSLVEKFSKHLSSDGVEVLKLNTKKQWQVRYFTICKEQVALTAHEALKPSGDVAQCPKALLWVKKFSPKSTYGLANIDKYGHGGMMLASLVNIHVDSRVEQKNPVPKKMQDKFKKAVTVTLEYNFDGSVKTVEFLCRDNDQAQFLCTCIRVSRDLLKREESLRQRLKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWI1</accession>
    <name>A0AAD2FWI1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
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            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1010" mass="112096" checksum="1BDAFCA32D1D475D" modified="2024-05-29" version="1">MGSETSKPLQPPEDWAKDGDQFRIISPMSDISNPSEINRVYNGVPRSEANITDPNRRVSKTVTRALASSNPNSDIPAPSAFYFPKKDTERRSRHFNGKNGKENKKGFKKMIKKSKKVMAGCFVSENDARANRNEAVNLQPIDINKIRRAKQTKSQELVIKQKLSNIEEEASNNSSSQNSKPAPKENFSATEIALHQEDVYFDRLSGGPNGEVHASPYVQNSAVRDVAPMLDDGFQRDATHLFDTIIKEGEDSMSQLDKSQHSKKSSQSRKSTSSKQSSESGSNLAENKSHVGLLSNENYEVLHRRQSRDPTISSNNERSEDESSPMSYGARQKKVDNVQSAFRIPGEPLMQVAKLGRQPRTSSGSRSSRSSRSSYTRENNVSKLESLFRPVLPALSADDATASSFDPYQIKVTESAPSQLEGNSRLDIQTGLGGNPNQLALLSPSMLSIDSQGKSPAAVKVLLSEQAVHNGDFLFTDYGPQRDIRKTRSDRESAVGSISTAGARSRLTNRSAKAAAVPSKASSAYATDSNYEYMKSDPIVHFTKSAQPTTVTIPTIETKMSDLSDFADLSVKDTSRETRVSFENSIPEEGDFNSPEEGNVRWAYTTADGKSRVTPYVKGMDTSQVTKSPFVRYQAAKEKWESQEVNDDQFAEFLKPSKTQSRDEEVAVIPEEQLQEEGLRETMSFDTEPRWSFGGNSDNQNKPTAFKPSQSPANRFGNRSSFGAIKERPIKSPKAIKTKRKGAGGVVTARIESIDRKVIENRRFKKKLNHAKKTSNPRRFQVVNTSYVRTQKLNGYAPTKVDLEKLNLVGGVKFNKVPEYGEDDLSSCQSSIYMEEKKLDTKSIFNLYPHDEFSPSHTDEELEYEDDADDDDDTRASTAASTVLQTRRSIQPRASESSYSTSGSGLSQVKKQVFDNNRFSLLSTSDSTTMSSIIGKENQTYRPFRHAPNSVNPSKQKLVTLPANLQVQRNQGPQKWRSLAAAAHEKDSAMQGLADWKKKRSNRNLAGSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWL2</accession>
    <name>A0AAD2FWL2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001880">
        <property type="protein sequence ID" value="CAJ1955071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWL2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1009" mass="113801" checksum="E64C6A7CB753BADC" modified="2024-05-29" version="1">MNALHTPAAKDWIRYNAAVPHLPLCLLLEMNQILQIVVGAAKNKTTQSKLCNGQPIMADTFLNAFSGVTQAISHINLSISMGNLGPYGTCPNLHAILTGKPTPAPKRESPNSRERPDPTKRAKHPPQGTHPGYLTYDGPGRLPIAPFKCKHPITGKQAAFCSHFLFANYHCNRPRCHNIHYTKQFAATMGSADTQAFEKFIEKTPGVTRLAPKPHVPECSTCIIPHPSSLVYQPTQPPMSHQPNLPRISTTTPPPSQPLAPPSAHHRSALPPDSQYYQFTDAEQEKFGEILEVSVQGRSSTPSMTKRDRETWAATKLPSPVFLAVNSPHEHRFVDFRPLQQPIPPKLTPSVAMHRWSRMFTACLLHYDLSIPTAVRFVGNIHTGAHRDWPTLEPILREANVDPFLITQLKRIFLDGAPNYVNAESTDENLRTFIAYGNHKTVYDDMSKTQSAVEKDILRNYLLAANPALLPYIRDAHTTPLGLVDACHEYRKPRIIFDATHHPSLTAMAVNDFTSKETEPEICFPRSFPNFLIWIYNLRITYPQEEIYICDDDVSGAFRHVKWNPNVVGMHMFMLFGFLFFCTGLSFGDNTSPAQWEVVAMVRQQLAQSLWYAAVTTIPRVAKYLPKLSLAPLPTPSDIAAFTPAKPDSKNQGVLNADGYRKSPTFDHHVDDCLYADVALFLHQTISASILALYILLGFPNPSNGIRDCISWKKFANTFSHERKTVGWLINSRRMTVRLPSIKQDRLIKLLSETLANPSLSFRDIAILLGHVSTATTVCRWMRCSYFNLQHVLSQFLRSRHQSIKHYMKRNDKVQTISDQLPPSLRYRLASLIRKEAATFLRNANKRFRLDEPVLRELRAIKHSLETETWEIYIPQMIPRDPHFTSYGDASFLGGGAYSDKLLFWFRVVWSPDIVTGTKLKASNPNYIHINSLEFLVAFLQEVATVVRLEGTSHAHPGLAHKFPNGFSRFPVLLNRTDNTPTEKWMPAQTALLHAFWSTCMVSSSNAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWP7</accession>
    <name>A0AAD2FWP7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWP7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053259">
        <property type="entry name" value="Golvesin-related_Golgi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32301">
        <property type="entry name" value="COUNTIN RECEPTOR CNR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32301:SF6">
        <property type="entry name" value="GOLVESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44471" checksum="32722215C2C60BA6" modified="2024-05-29" version="1">MTASSSSSITKYGKVLPIAGLLCFVGAMTLDYIHKGSLSLPQGADLNGRKKEDGSSSSYSSIQEKASRPLEHDSLFDYEGTNIATLENSVEAITARLQPRRLQLEENKAISHQILHLHNMKTGGTSIDKRLNCAIKRMSADYNVTIPRYNIHECWRRVYRECMANSTNPCRQEIKDAAVMSFCGPLQNVEMLGWAGQDRPEVAVVTMLRHPVERVWSQYKYQLSNCYRCKNLTFVYELFDSGDWPGYDNLCMSHLKDKQVRNLVSRDLPADATDEERVNDAIANMKSKFTLVGITEQMEATEALLVNAFPWLDGQLERSNASCTMQHTNKSPRNNGCIIDRATKQMMHMPVLQHPDNETRRVIEEHNQLDMKLYEAALQHFEVLKQAIGYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX39</accession>
    <name>A0AAD2FX39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS15828</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX39"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042246226" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="11">
        <location>
            <begin position="25"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="434"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="678"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="862"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1955599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="919" mass="101370" checksum="0EFE2AC2DACB7E04" modified="2024-05-29" version="1">MAANNILVFNIVVLSSFIIALTEASSPSSPQLRRQNYSLKRHHLIGRRRTQDDAENVVKNNDTTTSSSTTRNITFALIPKTIDNPFFDVSRDGCMDEAERIGGGVTCIYPGPATASVDEQVNLIRSLIQNKSVDGIAVSAIDANALVEVIEEATLAGIPVVTFDSDAAQTNRVSYIGTDNEAFGERLGKVLKQIQPESGTFRMVSIPEPNILQRERGTRRKLLEEGWLEAGAPSNMMGNSTLVVEQMFQFMQEDPTLTAIVPVMGAGMRSPIWHDFVMAYPDVLLVVADAMPNQLEYLNRAYCNGLVGQLPYEMGARSIQVLHDLYTGKSDPAEVPQFIATNVLEHLRIPLELPPLVKDYNLVGELRYVGYALFGIVATMATSFMGWAFVHRRMRVVKVAQPQFLIMVALGSLIMCSAILPLGFDDATSQVSDHPGITVCMTPVWLLIVGFSLTYSSLFAKIYRVNLIFKSGERFARVQMKEREVWIPLTSLLLANGVILLTWTLMDPLKYTRLDEEGLDGWDRPISSYGTCQSENSVPYLVPLGILNGVVLLFANWSAYEARSISSEFAESKYVAMAMASLFQALISAVPVLFLVQGSPQAFYMVFVFMIFVMSSAIILLIFIPKVVAYYEFKNQPAHLQQQAIERSIRDSGKKMRRSSVFRYSSWRLESDREMLSTLDNESSPELTTHHNFQQGSSGGVSESFIRASDDGQNKSSQMGRPFADSSEALTVSSWPGESNKPTTGGERQTISSISGSGSRSGLMSGTRSQHLTASSQSVAMSPVAEDGSSNEERKVIRIESTKSLKMKSLSDVDDDAATKKTVLPIAMNTVLPIAMNKSLSLSSMTEIMERNRAMWSKSLNTKQVSETDLANNKKKKDSEAEGKHPMKMTIIETKDKSGGKMSRMSSRMSSDDDSILSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXJ8</accession>
    <name>A0AAD2FXJ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="75" mass="8495" checksum="F17DE7ECC7FBAA9F" modified="2024-05-29" version="1" fragment="single">IVQWTMSSYDYVVAAVKNVKETLKVSPKWKMPKNAPTPMTSAYEPEMDGSSQLGQEDHTYFQELIGILQWATEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY31</accession>
    <name>A0AAD2FY31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CYCCA115_LOCUS16084</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="47"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="505"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="449"/>
            <end position="450"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAJ1956121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="639" mass="69757" checksum="2CECA27DBDEF1FA8" modified="2024-05-29" version="1">MFSKVISRSLQRRVPFVATKTSARSMSLASVTESLKGDYTIVDHEYDALVVGAGGSGLRAAMGLSEAGFKTACVTKLFPTRSHTVAAQGGINAALGNMSKDDWRWHMYDTVKGSDWLGDQDAIHYMCREAPQAVLELESFGMPFSRTEEGKIYQRAFGGQSLEFGKGGQAHRCAAAADRTGHAMLHTLYGRSLAFDTTYFIEYFALDLLMSDDGKECVGAICLNMEDGTLHRIRAKNTVLATGGYGRTYFSCTSAHTCTGDGNAMALRKGFANQDNEFVQFHPTGIYGAGCLITEGCRGEGGILRNSEGERFMERYAPSAKDLASRDVVSRAMTMEIRDGRGVGPKKDHIYLHLDHLPADLLAERLPGISETAAIFAGVDVTKEPIPVLPTVHYNMGGVPTNHYGQVLNTTVDPKTGEHIKDEVVPGLYAAGEVASASVHGANRLGANSLLDIVVFGRACALKIAEDHTPGEAIAPMPEDEGMESLSDLDALRYSSGSTSTAEIRSEMQVAMQEHAAVYREDETLKTGKVLIDSIVDKFNSDVKVADQSMVWNTDLVETLELKNLLACASTTITGAENRKESRGAHAREDCPDRDDENWMKHTLAYFDGKRTTLNYRPIHYYTLDEDECKTVPPMARVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FY79</accession>
    <name>A0AAD2FY79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FY79"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="467"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="558" mass="62933" checksum="8D7620E2158765A0" modified="2024-05-29" version="1">MTTNQTTTVPSFIFTDQAFQKPAFCGGFGMPSFGSSSTNNNHNETSQRGGGLSTEKEELDKLLADKMNGLSVKDRETMLEEVNGIAHSDPEEPSRLNACLEELDNHLKTLKEGTVYEQAERMDSAYVSNRAFRLKFLRAKRYTTPEGETRYDPKRASELIINFFQTKQTLFGSEKLTKDITLNDLTPEDREGIARGSLQVLPNRDMGGRHVVINFRGFAKFHSLKSEVRAKYYTFMSIMESEEAQKAGVVLIFYTVGQYQESKDGGSLAKQGRHMMTLPIHWAATQVCVDDYKQYILLKAFFQIVPAQFAAKVRVHFGTHLENQYTLRGYGIPEGSLPISPADSSLLLYNHLLWYNQREAADKERENSASTTTSPAATPQMVVSSSSSNVEQINTKDKTHKKEKDDLSLGIPMDEMDDDVFSLDPFDESDEYDTLSRSTSNSQIVSVETSPCRSTSPNTAISPRSTDILFGQSHKSHPGNLRFHEVITQHVGEYEAASGRQKKIEFAEHLVQHIKASGVRFLIYDKGSMRWMEVPDTKARNKVSKTIRNRRRSADYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYC3</accession>
    <name>A0AAD2FYC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYC3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="174"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="310" mass="35450" checksum="150FA217500E31DB" modified="2024-05-29" version="1">MTSWIWMQGVDKALVDKAIDPVSPEDDRPSVIDLIQEHADTIEKVRLGLQEDPLFDKTKHDDLWILRFVLSHKSKMKRCVQAAKTTLEFREKYKLDGIDLRHFEPPHFESKDLAIGGSPSVAHSTSLRFPKGALTLTIPNRQLGTVSFMQFAEIAKGDLQAAKTLSDVDWNAPFIAMSEWSFQWLDYITRTTGRLTKNVRFLNFQGVSFSAINNRKAGSRDGKIMGEMEDVYPQLLHAIYIYEAPHWIHVIWSMVRRIMPKRVVEKIDVVEPKTNADELKKILRFVDLKTLPQSLGGKNTVPPNEWPVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZW5</accession>
    <name>A0AAD2FZW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS17012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001965">
        <property type="protein sequence ID" value="CAJ1958065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1958065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12959" checksum="A1F3975D60C7D75D" modified="2024-05-29" version="1">MEAELIAVDNVVTMILWTKLFMEWQGYPIEKNILYQDNKSAILLEENGRKSAGKRSRAIDICYFFITDQVEKGNVKIKYCPTDDMIADFMTMPLQGEKFRKFRDLILGPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G127</accession>
    <name>A0AAD2G127_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G127"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="203" mass="23052" checksum="43370B175C3475A8" modified="2024-05-29" version="1">MSSTTAMHLSSTSSLDDLRPRTMKHQVLRPQHEGSSDSYSYSYSWTETEWQTLLMDAATSTATTTSSLLDGQQEGFVTVTLLLASIRDAMLQRQQRAATHCTNNQTFDHDQANRVIAEIDQILSPQEEEEDNNNAIAAQHEGPLNDAKQYFDAMLSMFSNGEVMNLLKGVYTKLTIMTLQQQQQQQQQRLIEEEEEKKEEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G229</accession>
    <name>A0AAD2G229_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G229"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041974225" description="SGNH hydrolase-type esterase domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="70443" checksum="9CE814E3EAC3A69B" modified="2024-05-29" version="1">MVFAAKSVVFCFILLLGLREVLEIGYNFANVKDVATKHDKTEHGIDQNIIIRRGNDNQTNALFNESSHDDDANDETKDISTDDESSSSSSSFEEEEKEPQDGHSTVWLRIWGSHIAAVDPNEDDDFSIGDNKGLWQRLSSNETSSTLSSKSILIDLFAAFPRPKQQNSAAVYNKDAYDSLISKLVKSRKQGRNFTIVASGGSTTCGAAKDQPAIPQGERYYSRLAGYLNALLTDYQDDDSTRQQTATVQWIGQGHGARTSLHTAIFFDSFIPVDTDLLLWEFSINDAIDWFGGDPELFRKSLQSDLLVWLEEVSRMKRPAMVMLIYYWNTPYHQNAAANEIVGQAFEAHASIAKEYDFVVGHVNLGSFIDEVYFPGCTRWETCPLLSDKHHASRLGHVLTAYLLLNLLNPSKELLLPPGTKEDDDTRSESSIYEWNCGVETDAKQILKQVLTAPTIGWKSPLGAWTLDLPAYDQMTSRQLVAGPRLGDIDLVDKADPIRQDRKRCTTLEYCGNGGTYFSVIAPIEPMESVQAVLLVLKKHQTVLDTTDVNVILNDSNVTTNGQLVAMRTEKDPSIFRKWPCHFSGGWSSFADTYWYIFEKPQSAVNSMALCIPSNARIITPPKIQAVAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2W1</accession>
    <name>A0AAD2G2W1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002065">
        <property type="protein sequence ID" value="CAJ1960581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2W1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041981238" description="VWFD domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44373" checksum="D8D9A8F547919CC4" modified="2024-05-29" version="1">MKFSSKVVLAILAACVSHSNGYVEVPGTNHLGDNYCKNADIEGEGSNPIYHDLARVDGQTPFSCDEICRTNNELGGLRGFDVNDQGICFCHYDDGTSPAGCPAPFSICLTGFTGTGELALDNVRDDFECYVYTTFPVPASFTTESTGDPHFRTWKNEHFEFHGQCDLVMTKVHNFANKEGMDLEIHLRTNMVRYWSYIKTAAIRIGNDILEVQGSAAKEDGIDKRHYHINFEHLGPLTHLGGYPVTISPRNNKYTIDLNKDYPGQSIEIKTFKEFVGVKIIGATEESFGNAVGITGDFHTGNTYARDGSTVLHDFNELGLEWQVLPSDGKLFHEIAKPQFPELCYLPEDPRGERARRLAESDITEEAAEAACAGLKDDFDRKGCVYDILATQDMDMVGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3F4</accession>
    <name>A0AAD2G3F4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome endopeptidase complex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS19165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3F4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042283346" description="Proteasome endopeptidase complex" evidence="5">
        <location>
            <begin position="41"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1961375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31531" checksum="7893BC6E9E746074" modified="2024-05-29" version="1">METRILRHNNNNSTAIRCTPSSISLLLLVMSSILLPTTNAMTEIDMGTTLVALKFDNGVVVGADTRTSASGYVSNKLAQKIHKITSPAMEDEKDNDNGSDDDDDDSLSCVICRSGSAADTQWLCQELTTDLWERKYRYCQKTSVRQVAHFLRHLMRQQGESSLQASLICAGCDEQEAKIFTIAPSGTLLEEDVFAVSGSGSTILLGHLDSLKMSMTKGDDGLYSEEEAVELVTKLLRLSIERDGSSGGLIRLVVMQKGKKLREITVYPDAPSSTQLEMNIPGFANAEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3L6</accession>
    <name>A0AAD2G3L6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS17489</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3L6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="11">
        <location>
            <begin position="521"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1959058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1168" mass="129661" checksum="22731303352768E9" modified="2024-05-29" version="1">MKSNEEKQFSTETTSLLNLPSPHSTDRPVQLDHVLSSDNLENGDEYHGQRESKRIEDEKASFNKKFNSNGGLRRVVLLLVFACIAAVFIFALIHFKSGDQNNSGSPGNAFGKPQPFSLNHPNDLGITSVARPKETAPPERLFRRLESPDSDQRQPLPTSSWYQNLLLTTGEPNNLHRAYALPYMLDLVGPIPGLTLHKGFLVPTDRVIQLADNAWNGLTLGAAADIHEKTQKKLTHQYTVSSPTELGVTLHWDAMNMSSSIVRGMAYGTMIFEDFKTNGGEDGILFPTLASYIAFGKPPVVDGTSQLECDDKGSRTLVEKEVELHFGGSDFTWLVFFSQPVWVQCSNGKESNNAFLQVVDVADELSKEPLVVRAALANSCTNGRVHNYCKSQLMDSEQQKGYGDLLRRYADTIPGENTSMKYQVLEGESEGTLVLDWDARSVSSGKSKDSSSTDLGMIHFAMPHHMDALDSSSLPDDKYCLPTIMGPACAVLGTEMTLTETIPDVDFRAKRPIPASFLSDIGDTLVKDMKYELEAFFQRGAGDTYFSGKMLSKLGRIALVAEEVTELCSKRMSREYDVACKNTTIPTKQAMDTTIDKLESSVEIWINGSAETPFIYDDAWGGLVSCGCYFNGKTCDNEVPNCPTLSDQGLDFGNGFYNDQHFHYGYHIYAAAIVAHFRPEWGKKHWEEVLLLVRSIANPSRDDTAFPLYRHKDWYQGSSWASGVPRPPYLNGKNQESSSEAIAAYESVALFGKVMQKIWTSDRNPSKAAIAKEVKQVGQLMTATELRSVNKYWHVQQSDPIEKRIYPVEYTGSVVGIVWQSMIQFGTWFGTAEYLPYGIQLLPLTPISEERDELEWMNEMYYPFSTSCASTFQCTESGWSVLQLAVLATVGYREEASIRAIALPEESYTNAGGNGHSRTNTLWYIATRPIVDEPIELVASDVRGAGEKRPAPVFELTDCHTPATCTDAVLDNMPDSYSCREHITFLIKMERKPQWDACTSVGVEYEESCGLCNPTEMVENTPKNATQAPTIDNSICPPCTDEECDSDLNRCPLFERSFVCTAGANVFGCSPIPWYFEDECDTCCEMTRCQNLKDIEAQKVTHDGTAFDKPICPPCPKEVCYGEINQCPIHTAPYLCLGGDNVGGCASHPWDVKKGVTCSECCEVKTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3M6</accession>
    <name>A0AAD2G3M6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002080">
        <property type="protein sequence ID" value="CAJ1961063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3M6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="458" mass="50885" checksum="8EA71FBA30854A2F" modified="2024-05-29" version="1">MSQVPAREHLKSLIDFYQAAEKLHREAEADVVFAKKRRDEARTMKAETWDQLAEARKKYDVADLEFPVPVPLPQRESSRRLVKKPVVRKSSVRSNREEESSPYPPAALPDEEGNLAEDVSPSRRYKPLQNEDELKSDLRKLVPLIPNLTEQDAPGTPQERTRKSNVAPVPDSAQQDAPGTPRRSQKSKMLPIPDSAEQDAPGTPRRSRKSNLPSIPNSTDQGSGALGTPHRTRKPKMAPIPDSAELVPGTPGTPHRSRKSSRRVLVSPAGRKSTVVGGSFSMHRRSIALESKNMDLPVLAICQGRSREWYEANFDAESLGLAKRFYQAALGTKTHATTNQVHISSVLLNDEWNKMATTTSEVQELYIGVSNTSDGKETLRDRAARALVQPRQQEPVAIFFAPKKTRNTEDVYYGGHWKVVAGKMLEPPRVVKGMPRQCLVSFVFCGVDPNIVKAVNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3U2</accession>
    <name>A0AAD2G3U2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS19154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3U2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="7">
        <location>
            <begin position="333"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="656"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1961353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="685" mass="76431" checksum="E90B6B1DEB16400F" modified="2024-05-29" version="1">MAKRTSPLSNTINNSDNSSKNNKNKNKKRKKNKNKPMQNDAPPPPPPIPVTVLSGFLGSGKTTLMKHILTSMDHGLKIAMIVNDMAELDIDGKVIQSAVVVNKPEVVTLQNGCICCNLRGDLIREIYRIQQLGQFDYVLIESTGIAEPQQVAESFCVDPETMELAVEQLTRTAGDNDNTPNVTGKMLLNAANLDTCVTVVDALHFPKYLSSLERFKDIFDDGLDQAATNSEEEGEKSISQLMIEQVEFANVIVLNKTDMVSSEKELNTSRALIKTLNPKAKVITASHGQIDVKEILNTGLFDLGQASESPGWLLSLKEHGVSGAPGEADEYGVTSFVYKNRSPFHPFRLYKFLRQFFCFANEWNASSPESSVKKIGKDDQTKAALNQKYGRILRSKGNCWLAGRDRHIYDWAQTGQIMALQPGQPWFCTLPAEEWGISLSIEDMKAIKDSFYGQDAKSGKKIPHDFGDRQSVVVLIGTDLKQEAITQALNDCCLSEEELKAHTTDLPYGSYADPLQPNEVVECDGVRSLFMVARHGQDQHFHVPRGSSFTIQNLSLLFHPVKLDYNLCYMVRVWLDKTDVTKRGVLLATLRAPEYEQHSMCMTILPCDVNGGEMDSNRRLRVEVIVTAKDRTDPTLDLMQLCEVHIVGKVEPLPFSEDDEMQAQEAMTDEDTDDANEDDEACKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5N4</accession>
    <name>A0AAD2G5N4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5N4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1963733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="444" mass="49571" checksum="688EE6BBBD68206D" modified="2024-05-29" version="1">MATTSSSYNGSIPGLKREHFTCDFEEDDEHQLCIPTMTKSKIYSDGQSFYFSWTASYGRRQKYYLQATGNIAKGDQWKNNGPKWWGFECRCSCPGYAEQEQKTIDSNYMEHHVCHHLQIALELCVDLMANKEPPSPTSVVERPTTEVDERTLSLPAPPSMEETIVPVTQRESPTKDNEYDAQIIIPGLTRLHFIDDSTRCKCRRAPILKAADIDQKCGEFEVHWQAAGEIGDDDEDECYNLRASGNIKQLEKVDGPQWWGFSVSCDCPEFLRQRLRCDTESGWTENFVCPHLGRALELATDPEQMKKGNNKNDTEGEGSMDTLLATDGSDAISRDFEQMKNYNNGNDSEDDNSMDALLTVNDSDGSTSIARYPERTRTYGNEDEDSMVYSADEHSMDALVTVDGSSEGSTSIILEGENSLGSLLSNIDNASVDGSSMSAILSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5T5</accession>
    <name>A0AAD2G5T5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS18769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002061">
        <property type="protein sequence ID" value="CAJ1960519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5T5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1960519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="360" mass="39986" checksum="6E6DAD9D44667A81" modified="2024-05-29" version="1" fragment="single">MAVARETEMAQNKILYSAKLGGNMRRSAYFETNKRTVKSNIMLKFVTKAMDIKLQGEANFTTTLEDPIELLKRIERFMKKSADAEYDFLDFWEAIQKLFAMKQGTTENLMHFKQQFLRQAEVLQDLYGVAWFRDFAVKTKAYAAIASTNTAAQNKFKDDIFEAVLATGFLCNWDQTRTAPLMLDLQTNYCREVDYYPKTVSKAQDMLKIHMEVSKNPGVNLYQGKDQPNKGKGKGKGKPKDGKKAACYVCGNKDHMSPKCPDRLLPKTQWKNQDQYVDYGKKLNLNQIGATVPATVPAIVPGASASTSGASSVAGSVNTPLQLAGTTGNQMMQVPSGMQLMQIPTQGGGTVTVPYSMNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6Q0</accession>
    <name>A0AAD2G6Q0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6Q0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="274" mass="31308" checksum="094F543107CFCD4F" modified="2024-05-29" version="1">MAFLSPHALRKRLQLRKRGRTNKTAGDDSKPADDSKPADDSKPADDSQRTSIGDSENSMLTSANAFERKTEIQPEVYGYENAIPDAAAKNMARASSRDPYGYELHDPSSPGAQPRRSSLKGSNPEPRLRRRRHSICFENEVKVNKVVPIATMVNDKGEMWLQGKDYYKIINKVNTIVDQTNSGKGKKYCVRGLEHMVKRRDDPSEPRSEAWDTVLYEQQIQQATGDYNEEALSRKYRCCSNQSRMKAKIRAIKDEQDVSTYLEDTRRHCRRMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G865</accession>
    <name>A0AAD2G865_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS21643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002247">
        <property type="protein sequence ID" value="CAJ1966059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G865"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042141508" description="Calmodulin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="127"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="320"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1966059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="74614" checksum="924F9D1450CAEBF1" modified="2024-05-29" version="1">MKKRFLHLLFLVTPSVTCFQARFCFNSRGVESPHQLSSQLSSSSASSSASSLHSNKGYGNSYLDSLGSERNPNPVFPTTPSTTTRSDGINQGMSQSHPREEKDPVSSASAPAASSTWGPSQHQTPAEALLDTADSASLPTSDDIDIDGFQVSSNGMYQIQTEEEYRKLITAFPNKLIVVKFFATFCRSCKSLAPKMLAVMKDDQLEGLPILWAEFSAHRRNKDCFKRLGVITIPTVHIYDGDRGLVENFPCPPSKVSLLKKKLARIINTRVDPNTRQLLLPEAAIDGEEASLEPRVERTIMNNELISTEHLDFLRNDLPFFQDLTDDEFDTMMQQARLLTFDAGDVIMRQGMPGTCFYVIKSGSIEMSIKSRFDDPISTPPTYLGGVVSTLRKFDYFGERALTTGEPFAASFRSLDKVRCFAFHVDIIPPSSILSRKREATQQTIDMLSQRYVLPEDYKSPNFYSTKRDEGILDLLVRFKQIRQAARCLDYVMQNGVNWGDSGSIARRTMLVRKLTYAQQNEYNDIFNIVDVGRRGRIKLQQIREFLANATKEFKNGLGGQEAADLVAQQQANQYFPDGDILIAREEFMGVMAEAEFYNLFKETFQELDHENTGYVRAGDLDQILGGVRDLIGDKRHTSIVDVDDKDMLVDYEQFSRMLLGAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9T4</accession>
    <name>A0AAD2G9T4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002288">
        <property type="protein sequence ID" value="CAJ1966440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9T4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="328" mass="37999" checksum="7E3AC36528085A28" modified="2024-05-29" version="1">MEEAILKRHPPTATHQQNQSNIPINGIFTTTGVPVLAGGYYAFGEFVESDHRALWINIDLNTALGNFTPQGSTFKPRKLTLLDKRSVKPYLQLAHLGYEEYDIPSRLTKLNQRIESNGRQMSPSLARKYNCLHWQMYMIRRHAEDNCRTTSSGKVPWSPKLQGFWDWLSLWKLLLKGRKQCRVSSQKVRRLMKKTRLCNAWKKTTDDLEVALTAEPRTYKQAKRQATQLRWDFLTVQTKDAKKKKWKSQKAHDRFLWLRRMKQREEARRHRHAQQKGSTGGLPAIQIEAMLPDGTTRLIITTETLIVNMLLYGHSIAGEIFGCKGQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G9Y3</accession>
    <name>A0AAD2G9Y3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G9Y3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="670" mass="76693" checksum="EAD739D7A241C7A0" modified="2024-05-29" version="1">MRHYKEDLNYESFSTDDANNNFRGFTSSINGMFVDPEQERVDCCSVACCGTLQADRNRYMVTGVKPPSCFRRFLLHIVLPCWIFGLATFCALNINEHWLNEIFSTGFIFILFSYFILQCFKGSMKRKQVRKELLWSKHELFTTGMFRMRHSDEDSTVESIDEQRLHRKSPEYFMGQSMSDINQAHGLCGFYRNDFPDGMKSIEGDDIHFCRKIFKCFSNACCGIVLCRQLQLCGTCALAQEGRELETILHPGYHRIDYISMQPMMDYYPAIYDHRHGNANYSIWGRLSQFSKELIQTSFVVLLCLFGWSLLADKVNHDFRPWNYVVCIATLVQATILMTIICWRSTEDISVDALLKYAACGFCLSTTMAIFFELLIGLTIRAVMSMVFELSGVTKVQSNSYSMGGFSSNFGADIFWSLQESSGNSYSDYLQVYGNDHPIMYTLYLAFKSYVLAAMVEELCKYYGFKMVEHPDFMSKNELEDALRYSYKEDSDHQTQKQQASFPRQDRGLRSKGSTITMAMIAASLGFTCCENLVYIFVYGDMTLGNQIYILVLRSLLPVHPIAAALQSVKVCERELEGKKIGLSAVILPGLIFHGTYDFLLLWIDFLSNRNGSYTAGDDAEGVELNWSDFTALGFGFATIVVGFIYFVRQRRKQLVRLSRIDSRHQSGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAJ5</accession>
    <name>A0AAD2GAJ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrator complex subunit 1 RPB2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034474">
        <property type="term" value="P:U2 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038902">
        <property type="entry name" value="INTS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022145">
        <property type="entry name" value="INTS1_RPB2-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12432">
        <property type="entry name" value="INTS1_RP2B-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 1 RPB2-binding" evidence="2">
        <location>
            <begin position="436"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2146" mass="238386" checksum="A71616902351439C" modified="2024-05-29" version="1">MSSPKTKRPPDLHHAVSVLQNISRDTHLKSPKAIGEIYLASLALLYHLRLDQATIHMIRKQNEDADNIPFPKANAIPAMMTVIHNQKLFRALVSCLSCSADDTTNLTKNKPLFPALQSRKRTHSVGGETPSDNPMSAPPHKFAKTTLSPHASKRAIRTPIANAQNSNSTRPEFNVRVLAATILFISFEHLDHWPVPLIQAYADDCFGPRLWVDLPTCGLLAENLALAHQEGGKVSDSPSQNCSQEATLVAEFYKDLIVDSHSEDLSEKVSSILSSPSKLVRRGSHSSVASNFSSVSQSSTGLPRRNRALSHDSVEKSIISPAPSINGDKESNNHSDSDSGDDEEIAVATNLTKSTDATENDDGASSSSGEEDEEEEVVLAATKSFDEDRNSSGKTMDPNALKLTYPVVQERLRFERIRQRYFGTNLDSAHHAIAHSLNGRLDLKSKQNSGLLQCLPSFTSIAPVRSLVAGSLEKWLQSPALAGLARNLFSTTVKSMQNAEPPLADDLEAIGCILSMRLKSNQLNAHVENVTAIAKLIPTRTVADHIYSNLLRQILRSVDTSESYSNQLKMIQAVYTSLPQKLSSDAMASSLHRIIVEQNDSNTTNSTPLINKVRDVVRAIATELGSAFDGCNLLSSLVAEQVPTESITMQDLGNKARILFQCATLLPKNYESARKSTSANGMDVDDDEADKSLAQTISDARHLLLKWCCREFAPHIKETKVKLEKEEIAGAGPADFTSILDGINTIKFSKWLDVARCILFLEDSSSERMKLMLALSPSDWEDEAKRIDICSKYGAIVDDEMVWTILKSASLKKGGMPKSMALSLLEHLFNSCRNGGNGTLDVRDPNIIWELYQLVEYIPPKTGQAQASNTKKNGKGNSSHEIDLDDPKVERDEERGIEDAEEKSTKSEIPKLAYPGMWWRATGLALILCGKSPNEIGSVAWKDHPTLRALMKMVTSDRFRFPTVDCDSIAREDMLKSEQSMRSREGKVTEALFSPPKKMLKKKKKDITSEGPRGSRMSRRQKDKREKQLKKQREKEAVQEKAEQIRRKKMLRAAQKSIMLWDPRNGARKPPKESVELIFSVNEMFDLAGAFQMNVEPDFLLKTIGNTTRGAIERAYDWLIPIISQIPDAIQRLPASASCFLLLRAYGTEGEERDQLQMLSAPLLLHVRNSLTGKFGEADAKRAFDLLLTDASFHNAERRRNARRVLNDALGEEKEISVETTSAFHDTKYSWMIKMISVEHATCFMGDAINFLYRAASFERGRTLRFHVLALEQLTAFANNAEIPGDWDFAAILVKLISSRPTVLAASMSSFPDLRSTAIRIVHDEFNANVKSPSIIDTENDDSNVEIKLHCGPDTADDTSKGVVDAVLPRALLQSSCVLLSIWLDDQKDTEENRAVRDLVKMLMEPREGVSESSSLDDKDGLASARAANTGKSAVPVESWVMLAKSRSDFIAKRAALTAPISFLTRLLLCSGLPRASLLTMIDRLGKVGEKAESQDKAFNQLFASSATSEWDIGRLGPRREVQRKLLGRLSAYSRMYGLNKLRSEDNTTLTFLNWLCDSCKSNEKQRKSKSKKAKTTASKTLGNLDRLSSVFGKISSFDLAGTETQIVQIKGDASDMAKFRVFGSEEMPVDNNTIGDNNVLSSIAKAFERNDLNNLNSLLELHFEHHTPPTKNRKRKRSSSDISSVKADEACYLLLQSFCATERKTESLACSILKWVPKLSVPSGSPKLWQLLFQPDQKPYSMWKNLISRCCECWSGRHVAECRDWILAQEKPHDLDLENSIRFFLLSSSLHSVDISRSGGSLPKGGDTSWGRTADTVLSVTKLALDCIVKSEDELMDSRLRSRNELPEPLIVLLLMARLGKKQVNVISQTVVERMKGADENALFRFRAIILRIYAYFPQSMNLGVAVLRSVLKSSVDSLAIDWLSWRSPMDDEYQDMLGSVVGSAAPIRLIQALAEAAKKHPLLLLRKAPYLQQVLSADAVAIDITEGSGKPGVVVGQNASGPLEAKMEGRLVKVSVKHWGFNYTESIWTALLDIVSNAPAEVLYGCGLKMGMKNFLEIYLRLMFIQTQLRTSERFTRLKRKYGDMLKAFEKSNPEEWEQWLSAEIADLHTLGAVRNVLMSCGFITHQQAIDYVKKSAQNEGSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAR3</accession>
    <name>A0AAD2GAR3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002329">
        <property type="protein sequence ID" value="CAJ1967481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAR3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="609" mass="68275" checksum="807D95438D9CEB4E" modified="2024-05-29" version="1">MDVRDHEGPFEPTPSPFRGSPSPPVPTMHDPFARAPSPYHTAPVQQSPFHPMPVQQHPHVTPGVYHTPSPYQPTPPSQYPHSPYPHPTFVPDGMGGYYQTMVNPAAMIPGHPHGGLVYSPVVAKPDIGDVGAGVVHCRKDGEPARQVSSEAVFRILMPSELGQQVMSGVDHKNDGNAAAVAMVRVIRYRAKLSLGPFGLLRLPSEQLLTTVMDSVFVRNGLDMNTWSVDPERPPPIDTKKQSSVLSFLPCLDTGMSSTMVLRGGITLDQARQLGMIIYYFFAMLSAKKPTYDGADYNDRDFQRSIFGNTLFLMCNTLMQNGDLMRLWMRYPEMCTTEYIRDLTELLYHLKSFVDYRSGADMGHYGIHEARLASHPNFPFMVVSSSMESQQSTTRTAHLKSAIQKYRDAMYDKWDKTYYSLQDPIWLSPCSVFLQASNQASGGSDRSSRHKLLHDDCNGPPKPGKDKEKDKVVFVNGTPPFVWNEARTPMRGRDPVVAFQSAKVPKGGYPHLEKPNNNMNGKKMIYPICLNSAFESHRKCHDSAACKVFAKHGKPGIGRTRVHIDLEDVKWSNANYPEANWKDVVAFVKKYNDYLLPTEAFKRLTPSTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB70</accession>
    <name>A0AAD2GB70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS22674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB70"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31469">
        <property type="entry name" value="OS07G0633600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31469:SF8">
        <property type="entry name" value="OS07G0641000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1967224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="70081" checksum="BB3DBA063F557C86" modified="2024-05-29" version="1">METFEKINVSGNRNKGKINSIKDNARRRSKSSFLSDYFLVITFTFAVFLLVWSHRFHHHDGLSTNHLEMKRIKESFISTSSTGKTTNKTRKIASTATNQHDHRLAGLKCDQWGGPSFDAAQEMVYWEDIPSDQNYLSPFHLKAATDGASELRIGQFLTFEPDGGGWNNIRMSMETLLAIAFNMGRTLVLPPHQKMYLLSKEEKKQRSEFSFEHFFHMQSISQEHIGFNVINMDEFLQLFLDGRFKHPGTGKPVFPPNNRTDWNSVAGPEKNILKDWLRESSKVLQWLPDDCMASFPRSNTAEAMEELENLEEAIFKEGIPNYEDYVGKPVPVDSSAKERLKENLAGRKKLCFYDTELQREPWIHFPVSHQGQYKARMLVHFYAFLFFADWKADLWTKRFVRDHVRYVDEIQCAAARVVHAIRTKHDSNFDTMHVRRGDFQYKNTRVSIDKIYTAISKHIHKNSTIYIATDERDKSFFAPLKKHYNILYLDDFLEDLGGINTNFYGMVDQLIASRGRTFFGCWFSTFTGYINRLRGYHADDHQTPGYEDGIIPSYYYTLEDRYDHMREFWPVKRAFYAREFPTSWRLIDTGVEEDIARPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCL0</accession>
    <name>A0AAD2GCL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS23841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Deltex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCL0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="564"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1969692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="762" mass="82966" checksum="54ADF46BDA9E964D" modified="2024-05-29" version="1">MMPSNHEESKATDSEDDRKPAALPSHRQRKQWQHQSQDGSKKGSFLDPPSANAVAATANRKRPTFDSSDDGLLASLSNCEKASEGSKNAAVKITKESPEDTANTNAVARNRKSPPTAIDSDVDPHVYLKGEGETPKISTRMKEKAIVVGTNNDCKPAALPTSPPTTPRKRQYQPGVDNVTDSKRRQTNQDIQNLNPNIPNCSALLSSSPQRKLDYQLAAMLQEQEYQLKKADAEKEHEAMTKSPYGKAVLVVQEILELTKNTKDQAKNEYPNFAQNFDSVSTDDMVFLAKNLLEKQREFLASGILGFVDIGYHYTDSTNLNSIRTNGLMTRNERDSQGIQAHRFHGSTYGDGVYTGNSPTKFAGYGNTGLIVGRLLGTMKTFGQQTTDGANTVLVPDREIVVLKTSAQCLPMIKYDMELAGSQEGQDFIQRLHKSLQEILDQVFNPGLRGPPVLPTPWNVATASSNARGGNATVPPSFIAQNSFVSSNRGPPPTQYFGPGSSFKNLPGPAAVNRYLIGGKSNPRISTIGKAVLQYIAPERLSGAVNPTEAFCLPPSSCNFQSDCVICHDALSDPPCCVALKVCNHVFHKDCIEQACKFGSKCPTCRKCIGTPLGKSPSGSMSISITNKLKCSGFPSFHTIVIVYSMQAGTQKHYHENPGQPHPDKHATAYLPNNTFGRNLLKRLKFAFLHGLTFTIGTSMTTGATNQCTWSSIHHKTHPDSTVHGFPDPNYFANCNGELDSANVPAANLLDVDGQKLVTTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCN3</accession>
    <name>A0AAD2GCN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002469">
        <property type="protein sequence ID" value="CAJ1970124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCN3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="284" mass="31886" checksum="79596C295B2DF7A3" modified="2024-05-29" version="1">MGMRRIDGSCFFAAIFFVVSGIFRTILFGRRHGSHSETNFGLMKALDGEYIRNQWEDIDGVLHSLRIIQGILHILAWIITATVLFRAAWLQSSRGTHSMGLHCSVAFLGATIAIVELLVHMLTFGSMMALQWMASDFTMENWYEIEGLGADQQDLLGWKVLEVVSIAAHGMLLWVDTIEYFFLATVLILLFISTKGQASPLSTSWSCFGLGIAFFCILDVAAEVLRFNNWRLFSQICFWISTANRCILFPNWLMWLGVQLAQAPTAMKQEISIAQMEGDAAGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCR9</accession>
    <name>A0AAD2GCR9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002465">
        <property type="protein sequence ID" value="CAJ1970111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF0">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="134"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="205" mass="22671" checksum="93E2F079805448F4" modified="2024-05-29" version="1">MSKPDDFSPLEAIEFIFVNDKHHPEPVYKNRFGNTLELQAVRPDSELLPALRKIVADTLIAPYATEAKDAQIIHQLVDIAPLTVLNTQTDSSWEAAGEFVLTAIGVEPPMSAQPDMITTTPVEYMDNMTNLTGHLAMPSAEWMRPLPAVIILPDWDGVNTYEQERATALAELGYVAMAADMFGSDKQFPTASLRLENSELILLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD42</accession>
    <name>A0AAD2GD42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002458">
        <property type="protein sequence ID" value="CAJ1970080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD42"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="113" mass="13328" checksum="30D86821A8C113DF" modified="2024-05-29" version="1">MNKSQSIPISPSSYLRHEDMIRQQRSHWEYKAMMVNADLTDYLVYNRIIIGIAKTIEATKNAKLRDQNQALVDHIHYIRHTQVSSRAVRKREADDLISRKQDDDEALIFEMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD94</accession>
    <name>A0AAD2GD94_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD94"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041915558" evidence="1">
        <location>
            <begin position="20"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1969448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="286" mass="30683" checksum="56FDA5B83D8BC265" modified="2024-05-29" version="1">MTRLHLPLLLLAASASSFAPNVQTVHRLAPLNVGATYDGDWMEQAQSCADSDSCSLEENKLCLEHVLLIQSACSAGTLLGDQVCEDVTSAAEIVANLRSKIDKQSQVLSSMIAGTMVASVPVLLGLFAVIATVGILADPNAAPITPQEWWWSIRDGYFPLMLKEYYGNGGLAGASLDATPFTLQEFGWAIKGGYFNTLLWQFFQHGGLPIDDCLAAASTTPFTPQEWSFAAKDGYLQQILSQTFMNGGLEGAESSTLPITPQEWVWAAQGNYLGDLVKSSIQNGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDN7</accession>
    <name>A0AAD2GDN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase gamma chain, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS24419</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002512">
        <property type="protein sequence ID" value="CAJ1970401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDN7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000006">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000003">
        <property type="entry name" value="ATP synthase gamma chain, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004145">
        <property type="entry name" value="PRK05621.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF41">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042110262" description="ATP synthase gamma chain, chloroplastic" evidence="14">
        <location>
            <begin position="16"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1970401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="369" mass="40199" checksum="EBB63320DE557A3F" modified="2024-05-29" version="1">MRFLCFASALATACAFTSQPAAFTTNSPVVGGRVLEDVVASGQAHRTRKSTIVMDGKANAIRDRITTVKNTRKITMAMKLVAAAKVRRAQDAVLATRPFSETLQSVFGGLIQRLGDDTVDLPLLTQREVNKVTIAVVTGDRGLCGGYNSNMIRKAEARFQELKSQGIEADMVLIGKKGISYFTRRGYPIRKTFECGQNPNAKEALAISEELLNTFLSGESDAIELLYTKFLSLIASAPSVRTLVPFSASDITQKGDEVFQLTSESGDFSVERTELDVAEPQEFPNDMIFEQDPLQIVNSILPLYVNGQVLRTIQESVASELAARMQSMQSASDNAGELAKKLSLEYNRARQAAVTQEILEIVSGAQALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDY7</accession>
    <name>A0AAD2GDY7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002451">
        <property type="protein sequence ID" value="CAJ1970040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDY7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="104" mass="11492" checksum="2C5AB6447EE89F17" modified="2024-05-29" version="1">MPVTTNEMRQAIVAEETLQSYTYDIMQILADGCKDEPIYLQGWVTDAAKVSYKAMIALLESQSTREQGTTKKTGSRSSYLTACINQSCMSAIVKLSTSWHSSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGS9</accession>
    <name>A0AAD2JGS9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGS9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1947995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="686" mass="76394" checksum="2E6EB1825786CA68" modified="2024-05-29" version="1">MKQTPQDELLFTSDSSQEEISRIERGKSSQNQNYEIIEASSDDDDADDADEVDTQDQGFSMSSFGQSSMSMLNKSRSFLANAGRPLRTPTIFAPRSPKNYRPLRKSRSADDMLGPSNHGGTEMASSPPSPPSSHGRSQSQSRDVFSTPKYLSKSDLMMKGSSHHTDDTFQFPSPFAARHSMNFGDFSPSIDINESESSVAATNDDPVQRISIRRISEGDAFQAISDINFSFHESMDLEDVFPSVFDDDPHRPSSSMPEMQSPLPLQSSSSNGKSGNGSRGSSFEHAMAIDPFEDSCVEFAPISPAREPMTTSASSQLVDLEAEMQALQKHHRQEVNDLRLEVETGKRIIGSLTKQVQDLMARNEKLSRQNDRMAKESSESYRHHNRQKKVARIDMMGHVTESPDSSPSIQQRHKTVTTSEKRHSKAKAAKRKSKKGKNHRISADDDNDIASTSTIETLMLDNHTTKKSKKRSSKAIGTTKKKKPKSKRSSNRLSTSSASLEADEHPLSQAKLRQSMKGKTQRHSIATSSHEKGVKGTRRSSSRLSETLEHIWAFDWKDPIKLEEKRDSSQKRNHQTKSLTHFKENLESVGKLPKRKGKRKTSKAKQGTGTNEPQDDSMNPTDANLIATTATSPKKAKKSNRSAFEVVTRLLSPKAEKRRKRTKTELLDSSQADSNMVQLPVTIPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGV3</accession>
    <name>A0AAD2JGV3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="399" mass="44356" checksum="F1C5902EF58DC3B8" modified="2024-05-29" version="1">MKLSTKSLVLLTPRRTSFALVSLASKAGTGVHKPVGKDGEGEYTAATKGCFDVIDTATPAILGEIFKQDAISSPRAYHIADYGTADAGTSLGLLSRMVESVRKHNNNDEQEVVVHYEDQLTNEWQSVFRHALGLKHVKDAYGNHIETPIALGNVYAEASGVGFHNQCYASNSIDFAISFTAMHWLSSCDVSSLSGTPFMHAARCPEAPQSEKVQAADDWKAILKARSKELVKGGRFVCVNFCVSKEGYFLGQTGKGKSMWDSFETAWNQLHEEGLIDDKEKDAISFPSYYRTMDEFLQGIGEVGGFKVVSAEEKIVPCPYRELYTSGKTSFSEREYAEWFVPTTRTWSHSTFQSALNQERNDKEAIMGKFWDNYISLVAKNPTEHGMDYVHAYIVLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH04</accession>
    <name>A0AAD2JH04_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">persulfide dioxygenase</fullName>
            <ecNumber evidence="12">1.13.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Sulfur dioxygenase ETHE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS12320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12981"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="EC" id="1.13.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.18" evidence="12"/>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH04"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000013">
        <property type="entry name" value="Persulfide dioxygenase ETHE1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1949897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="243" mass="26368" checksum="A4FDD121650E7057" modified="2024-05-29" version="1">MTIVRADQPMGLKQLFDETGSSTYTYLLWDTETKDCVLVDPVDVKVDRDLKEVEELGLNLIYGINTHAHADHITGTHLLKQQVPTMKSIISAASQAKADLTVANGDRIVFGNRSLVVKSTPGHTEGCVSFVADDESFVLTGDALLIQGCGRTDFQGGSAEHLYQSVHSQLFSLPKSTIVYPAHDYKSRTQSSIGAELESNPRLGGGKTQDDFVEIMAGLDLAYPKKIDVAVPANMRCGVPDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JH46</accession>
    <name>A0AAD2JH46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JH46"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="561"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="732"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="815" mass="93940" checksum="2E42DC9BB44A75DD" modified="2024-05-29" version="1">MERYFQKRVAPCGANLNASLRNGCIRLEFPTKQMQRAALKLDGSLIGNGRRISLQKWIANEKVISHEDDNNFPKRNRPTYAVVVKNLNPTNKILFDLECYFANRIGLDRNDLHASRMKSGQKILLELPSRQKQEAALRLDGSLMGSHTMEVQEWRGGGLPKNRENESSVTDKQESDPLKEDLGSSSDVGDGDSLLSSPSKSLSLKPTENKDNESTRKKKQDASSEIFGEPLESVQSPSPVEIESKDRLQSAANEHIKVLSAANSKYEKRIADQFSKIEELQAQLKNYQLQERSPRKEQLGRNECPNDMSESRLTTLCHEKDAQLRNRQSEIIALKASLRDAVAARNRQEQAIRVQNTNTMERLNNLKEKKDAEIKSYVSNVQSLETKLKEAATLNHQKEQMINILNHNVKMADEQIRNLQNGMGNTRDEELLRMQYRKKDFELKGLKKQVILLKQDLVDTIALKDDATMQCKRKDHDIDILTKQVVRLKQNLADTVRRKDDAQAKFEKRIAEERTWNAQLEGQLSRKTPLSPGKIALTGKLSPQGNEVDLSKRLEILKKDKVESIRKLKIVQTEKEEMQRELEDARKDVDDISRLLQDKEENLRRELRLMEDDMEGYRRDLKAAEKVIDELYNRLKKKDEDMQANKIKVVRQRAQISSLQVKLKQRDQSLESLKETIRKMKEEMTLNKDPDNKYHTTTKVEPTPRQQDATVTELEAKLFNVIQDQNVLLAENQSLRRDKQDMQRTISTIEANNEEENEQLREEIEQMKMNQAMELGLMEGSDLSEEVASLKEELEKAYRRMEEMEKNGLNGNATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHA1</accession>
    <name>A0AAD2JHA1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1514"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1613"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1686"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1517"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1613"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1712"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1733"/>
            <end position="1745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1782" mass="192508" checksum="FA6939124BFC895D" modified="2024-05-29" version="1">MFSSLLSTLSPKKLLAASISKSLAEFFHVDPEQVETNLVQDARVTLKGIKIKQRRQGRLLVFGSVGQIEFSWAWDTGSFITDTKLTVKGVDIHVRLINDNDQVDNNPNGASPSTESSLESSSQATLGAENGKDTEWKARYKQQIIDHMTLLITDVSISIQAMDESSQVVLQAKSMELQTLHQVGDGKDGSSALLQEICLGSIAAWIHNDASTRHSILDPVGYRASVQRISGRRFLDGVLSGLMVQGNPRENIDETHAASTIRVHAGKHQLVGLKCLQNVLQNVGNDTRSSQGEEKDSVKTDSKEQESQVSLLNSTAGSIFRLPIQSIEIVLDDDLKLGLEECEVRYCMDGTELSLHCNGGLWMDGSPILKSSCVVVDFANFKLELDAYSSEEGSEVFYNAPNIVSPTDAEGELGQVRNDKENVKLMFSIELFRRLYCSMSAILPECQEAFALIKQTKKSNLEFRTVLSTSTPWTILAKQPTSFHFTGHDNMWIEVTGIGLVIEQKYTTDSDFPFTISCRSARLESCNGLSITVPSIETSGNTIVFSDRVSAAFESIDSLIPLKGIWEDVCCIIGSQPSSDIAFDYTIPCVDVSCSEANFGNIAFGKLSGTGSIVRLKSLRLQDIKGLSLEARHLELSLENRDICLQIKEIMTCGYGGNPMISVPVQNLELKHHQNSLSIACDDLAMIVPYRRHDDEPKTTSTIEAAIFELRQLERYAKSLHLQAKKLILSTDAGDVLATQSMNVSIGLGASSNFGVTMRRATVQNIDREEITCSGIKITGNIDFPAQWSSSIPRLPVWKYFSSAKLAVESIDSLMLHDFGRLHAPIENMIILFGNDLATVRCKSIKFCPKLMPKGSGGIQPPSAALNWPTLRFEIERLMLMPEFRPGKPGLCFDRLGLFCRPQGSALLVVMECSYLQGRGPNSIDFAIKQVKISAMKEGAGDSTGKTDLFGFREAEVSVGELSSFAVPGKFRLAKPIPNFTAQFKDGEVESKVVELHVICEFGRNSQMANLSIGAPDLTTSLPIVRVVVQKGDVEWIPVKAPDGSRACISFENSEFRLFQDYSAGIRFEVGIDSIHGKKADGSAVIASQGQCAVVMQQGSNEVAVLETLSIPLIGSLKSVKLSFSEVEVFHVPNFVNLKNPSRNIEVKFSKNKLVVTARDISLQRFVQDPIYQKKAQAPSFDFPCNINVSVVTLCVEDITQLKVTSRIIRCSNFYVGLEPTLAMIGSGIESPGAGAFFRCQSLEVRDSSSIVNIPELSGSGLLQCNMPDTIGNLVIGLEKAQLEADFSSMEWSGPGRRQSFNMKLPFAAIPKFVLTLKCVGTLLSVEDATLACEAFEGTSKTTLDALKAHYVGIARHRIPYILAAKTSIAGANIGDSVGMMAGSIVTNTSVVGAAVGVASRDAVGSAIRQGKAARGVDESEKYKFGDFTRGAIASVKGAAKSGAAMRNDEQYQFGDFTAGTKKSASSYASKNRMRLAGAGGSAAGMIAGAAILGPIGFVAGSFLGSSAAQSSVRSITGDHNDNEETQREEPSATGSNVEHWSLDNRRDQTSASHGGDSSGHPTAPVALNAEARMVGGIATSEQRGVMAQAELVDLLSSELPAVPVILPTSGATPQCAQATRPQTSASKTTMPVPLGRPTSGNMSGYSRYHVADTPTPMQASSTSMSQYPVAPVTLVAAATNTVPRAQGGIPRQLHGNQNHFNDGYHEDNAARAQNPSLQGNSIGQMRSPSTTQNNSAAGSQQQQGYRFGDVTRGIVARGRQLDGREENSGYQFGDFTRGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHY6</accession>
    <name>A0AAD2JHY6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS13656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001811">
        <property type="protein sequence ID" value="CAJ1952655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHY6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1952655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="384" mass="42961" checksum="6C01635F528F1494" modified="2024-05-29" version="1">MAYHTLHYIGPTPGASQLESGISGGGIYVDRVVQESAVDGLVQDQLPDDAILLCLGTNHAALKNELVDKMKSPSCLVEILLPLLVSTIGSKSPATFVQAGIERVREGPDSPMAFISGADEWMRQYSARMVAMLPGSVRHEMLSFRVDTEYESIFTVRNKIEPVCSELKKIIHFTWKAFGLIHGFVDERAPLQVPKYLYMLSLQNGENLIDGSPELLQYTSFRFFESSESLKGAYAIGSTLATILYICRLGSLGEAFRCNGNNYIGRQLALCKEVQQGRVIQTLSPLIRQVREYEKQRKNGRSGDYVSQNGDVVVSGSRYPKALWSQLIPKIRDRFQTLFCKILGANGNTLVSALLDPSFSLKTSFGSQWYHHRVFYEKERGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI24</accession>
    <name>A0AAD2JI24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein xylosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peptide O-xylosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CYCCA115_LOCUS13582</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>UDP-alpha-D-xylose + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
            <dbReference type="EC" id="2.4.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 14 family. XylT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.26" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI24"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030158">
        <property type="term" value="F:protein xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043538">
        <property type="entry name" value="XYLT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025:SF3">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042170653" description="protein xylosyltransferase" evidence="21">
        <location>
            <begin position="25"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="684"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="759"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="687"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="759"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAJ1952496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="809" mass="92832" checksum="BEDD8349403D75C8" modified="2024-05-29" version="1">MMRTTIWAVIGWIVLVNCFLLVIANAPPGQSDDPNDPRNRWKTFVDFSGVDVSGDPAEAARKTVDFYNSDLMSRIEKLYEKTSTTECRSLIGEHFGYYLKAFANEKPLPFSDKTFKNTCEEEDEYDFDNLPPGVHMGMIQNRTYQPPRNETKYLEPSEIVLCYGILAHDSPSATIRIIEAVDEPTTQFIVHVDAKYEETHQVLKEYASQRSRVTVLDHPHRVRVNWGGFSMVNATLQMIYHADQIEFTHFVHMAATAYPIASNRRIRNTLADFPADANFMHVVLKPTSPALPIWNYYVECDDRLHRIFELPPLRKQVHGVDIFTSSQWFIISKEYANFLAHPEPGSFLQEYMDYMKHAVVADEHFFGTVLRNTHFCGKHHNWNFLHLQFDQWENERDLNMRDERKCIMPDPNHCGRSPTTMEMDYLDILELSGDLFARKFDDEVDPTIKDVIDRIRAKEEKELIKFNITKPQAPALHNPLALDGHGVLFVAKETISSENPLCMGLGEERNKVRLVPCFYEDVPPTLASNWETGAVILDETVPHNRWEIGPCSSDGDLRKLYSGDVEVIPGQYNPTGPRCNLKVMDGLRVGRCLDGESFDPQPGGPVHVFPCHNRWHQYISFGDGTHAPTGALHTNVPEHTRKRIAETGREQEAYMCLGLEGRGEDEEDWLGKRKEMMEKMLQRELEQMEQDSDDSEDEEGSLVDQKEDGEEDATETDAATEEEGPLDIWHWEYEQLHAIKCSNKEAVIEWVLVPFIEEDDSTTVYEDEDGSADSGDEDGPEEMEWPDPTEDSDVDTKTDKKHENKEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI36</accession>
    <name>A0AAD2JI36_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI36"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="202" mass="22430" checksum="179B1F666DBB10F0" modified="2024-05-29" version="1">MFVIVLVFNSGEEEPEAEAEEENYAEIPVANDRAAGGGYQDGPAPGGGGNGGPGSLTPGQATRGTLHYAGNKQHYYLFCNATRRLDEETLFDCTSDTFYQFMKNLGERADEFGWSTCGGILHVPKADGTMVNLLTEYGSITLEEIEIHECSYWNNGYRKSQDDRMLYKCIMKSLSTLGKAKVNIHSSDYKLMAGRYSAYLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJW7</accession>
    <name>A0AAD2JJW7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJW7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053139">
        <property type="entry name" value="Surface_bspA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661:SF3">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45661">
        <property type="entry name" value="SURFACE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="540" mass="60585" checksum="359FD7FED815CB6E" modified="2024-05-29" version="1">MTLSDEDAKGQVVNSKERIDDQTKSKWHAQVFVYTGGNQKVPHDVVRGRIHPSCKRIEKEAFKERESLLAVEFSVGLQEICDGAFKECAGLEYIVTPSTLKKIGASAFFGCLNMKFIKLNRRLEHISTSAFKECCALEIVHLPPTVSKLGAFAFSKCCLLKEVALSRALKKVHKGTFDDCPELDLIVKQNYTLFAAGEPTDVKIDTNHRKASKDVFDKLEKLIAERKKKQVNDQGDSKPTIQTASNEDGKPAETLNIGNALKEKEKELANLHATLERKTEEFNALQSDMEGKLKKLTDDNESMKDKLQKATEENESTIEANVTLEQENECTRKAYNDIESKLNETESKLQSTKDFLEREKCEKAGTVERLLEITANYRALKAENVRLQKEKEDKDASLLKTTEKVGALREQIKTLRKQEHRRGHDSVVSADDTVPNDLEGISIGLDSSQSRTARSKVSSVTGGEHFESCAEDLESSAKRSWQSTRKRKRTPKEASTKSPENCVKHVKALEQRLAKMKKNLQTTETEAEGETNDTNESQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK83</accession>
    <name>A0AAD2JK83_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001913">
        <property type="protein sequence ID" value="CAJ1956291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK83"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="369" mass="41390" checksum="2585B60EF7ED476A" modified="2024-05-29" version="1">MLPTCIADSFEFIFPPQGPGVSRVMLCRLSLQIDNHVLFGAWVREVNDMMWERYLQKSNQYLELLNDWLEKWPSVSSYDGSPPLHCTSYDGRPIIPYSAFGEAGHHNGIMMTENLAKTLFRLVEGGKRLQYNQNLFAAWQDEGLRADDTFKICKKVHVTTSGKKRVKPFAGLLTLLSQKGKIVAAVFKSSMSHDTNTCILQEVKKARDYVGAPRLRLLQTDNPVGEQAPYYTIFPELKEGIVARSSLPSIEIPQTDIAVLDDATAINNYILTFAESFPGDTDIYYGLDTEFERDGQKLTVLSLAFSQSIIGVPVAIVIHLHKIAKRDFPNSLKRLLEQHNMIPTGRLIGGEGWSCTTCVELIGVLNDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKC4</accession>
    <name>A0AAD2JKC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichome birefringence-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKC4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF48">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042053417" description="Trichome birefringence-like C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="3">
        <location>
            <begin position="262"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1957947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="425" mass="48400" checksum="8515AB2C7D09C61E" modified="2024-05-29" version="1">MLVRFSMGKCNTTRGLCLLLFIAVVISLVMASSAALSKHADEAMSSSVLVKDQSPPLSAIRKNSDACQDACLWKSGINGSWVQDFDFARDHGQFEKPLVIKDGPFQRRTAGAFQPSEDAPFPWRTSWRWVDHESDCQVDILTLDKFCKVLQKLNVQRILFFGDSLTDAMYTGLANKIGHANFRLNPDNQRNGSMICPVGGVHGADDRIIPVFDKKVSADKVRPNTTRKMIEFDHEVRHFLDISPADRVLAVFNIGAHYHDVNHYRQDLGVMLNLLSNMNRSQDLYIFRATSPGHEGCLPRTRKFDWKVGTRIVPLAKFEDYKVTVGHQHDWDKFEGYNNYTKYVLLEHNRKGLGPIYHYLDIFNMTALRHDAHAAPADCLHFQAPGPVDWWNHFLFTYLSRLSKDGQLRGKGSMREIPTNCRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMX9</accession>
    <name>A0AAD2JMX9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dual-specificity RNA pseudouridine synthase RluA</fullName>
            <ecNumber evidence="7">5.4.99.28</ecNumber>
            <ecNumber evidence="8">5.4.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">23S rRNA pseudouridine(746) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ribosomal large subunit pseudouridine synthase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">rRNA pseudouridylate synthase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">rRNA-uridine isomerase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA pseudouridine(32) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS21019</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(32) in tRNA = pseudouridine(32) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10107"/>
            <dbReference type="Rhea" id="RHEA-COMP:10108"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA</text>
            <dbReference type="Rhea" id="RHEA:42548"/>
            <dbReference type="Rhea" id="RHEA-COMP:10109"/>
            <dbReference type="Rhea" id="RHEA-COMP:10110"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.28" evidence="7"/>
    <dbReference type="EC" id="5.4.99.29" evidence="8"/>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMX9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160142">
        <property type="term" value="F:23S rRNA pseudouridine(746) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160151">
        <property type="term" value="F:tRNA pseudouridine(32) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF91">
        <property type="entry name" value="DUAL-SPECIFICITY RNA PSEUDOURIDINE SYNTHASE RLUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042173537" description="Dual-specificity RNA pseudouridine synthase RluA" evidence="16">
        <location>
            <begin position="28"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="17">
        <location>
            <begin position="197"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1965243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="437" mass="48636" checksum="A0393F67F9E7E749" modified="2024-05-29" version="1">MIASLSFTTLIHYSIVLLFIWLPVVTSFEAHPTSNAPRTPRHSLSAHSETTSSLEEDDHGEWVLNPETNRRIKKDGPKWHDFMNGQGGYICHNSKLVPIQLERILTWTQQEEASDQSQKALETADDSVVGATPNTAWRRLAPEILSSDEAPNDVDKESLPFLDELLFAFKPASLLTLPGIGEDKQVCLASLVNEWIPENLTVPPKKRESSDDKKKKKTKKKKKTFVPRPCHRLDYDTSGVLVIGLTRDSLRLTNTMFEQKGVESGSPSKVLKKTYVALVAGAIAQDHGIIDYPIGKVFNEANGYSEFVCLHDDSQRKEDDFVEKSLRNAKTKYTVLNRFTLPVACSTGNNGPSSQDSFVQYTKVQLEPLTGRGHQLRLHMAAIGHPILGDQLHAPNTIVAAAPRLCLHADELEMGVRIDEEQGVCVALVRVRCVPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUF9</accession>
    <name>A0AAD2PUF9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1950128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUF9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1950128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="676" mass="77242" checksum="BF2801C8CBD318C0" modified="2024-05-29" version="1">MAQRDYSIEFDFSHKDFEKALDEGRSLDSLCITEEFLDTQNTRPTEKRLEAILSKISEMWSLQGVYLSLQKTAIPGRLLPLAINPGLQELKVHSGLEINSLQDCDILAATLKQNGLSLKRISLLNIRVRLNAMASLGRFALGSQKPILDPLLEAVPDLEFLETFEISCRDSEQNTKGKPLISTDSLRSLCQSLSLKRFNLSNLGLGDEHFMAIAQELSKKPPTLQELILNENFNTELGVEMIIRMLLDTPNTTIRTFQAFQKTSQLSPACISLMRHVLEKHNTTLTSISISTSTDQEMDTLQYFEQLNSAGRHLFLQKHSTADDWIRLLESVNDDHSMIFYCLRQSKFWWNCIDLGRSLSRPLMKSKTLDTDTGEEQSDNEVKVVVGESDDENSEELMEQLKSLGMSNELELDYSDHETNVSSQASDSYLDDLHRQKDTLIDSTREEALEEAHDIYEKKFGKDSAKEDEKAFLELFYKILKEKEQQMDKMYEKQDELIAKETERQRQKSEAEKEAWMLEKEAARRRRRELAQEAKEKERQDKLTAASKAASSRKLSSSPAKKKKPKKKVAAEKLKRTQTEADELREKWNKARSKTRAAKKKNPESYDKLKGEEDSLFNDWVAKKAEVKEAEIEAQKEAEESQEEVNPEDGAFGSVEDVWAALSELEEEAAQIARDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUX2</accession>
    <name>A0AAD2PUX2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001817">
        <property type="protein sequence ID" value="CAJ1953093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUX2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="673" mass="74962" checksum="6B27E60B0BF6507D" modified="2024-05-29" version="1">MPGDDEKSLFDASGSKIVPCDSSAPGFRTSVRRRSSLFNTLPTGRSRSEKKSGICDNEQSQSQSHSTIVLESQMLSNTALELPSQDRQHKKRKSLFGAVMKRSDYLEPAADTIHRSPNTPAINKREVEESNLFDGIGDSVMSPTGKTIMGFVNNFGSSPFRFQSPKKMSLVHSEPKTASHVDHKQRFISKRGKYSGVAHNYLYSKRDDWLEIPMVGDQLACLDFSLRTTLLVECSNQLKFCLRSVLVQDNIQKHLKYWIFPHLPLGSLSTSLPLSIGHNARSGKISVRGSSKIDFSKNPTQETLEMSAADLNKRLTDLLKADALLYSTKHLGKSQRKIIATNLTSSMYPLRWQEATRSIFLNWCCSIKALSTTTTNTTRASNDTNTNKKETSMIANEIYFYCVAKDHVAMFRVDETVDDNMENKYEPRVILSNITADFQRKLEGEGVDEIQFLNDPKSEVAEGFSPRQKDSFAPMSPNVKAELEALRRAQVLGENAGADVRVKSDAKRAKISPASRAETPCSICGFDNVSCFFEVFLNSLGQMNSIQNQQPILPILVCDTMGPFLHSTLETLESRPVKTTGAQSLRLEGLIMPSAFRNVVASITREVTKIGSAPQPQRDVSEDREGTSYVLIETAINNESSPVSKQLEDSRAFNGWNKNEENQIIALKLVDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV74</accession>
    <name>A0AAD2PV74_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV74"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="233" mass="26838" checksum="1A42BC186F636A27" modified="2024-05-29" version="1">MVPIVTLQQNVLKPPACEDRFSTRISGSDDIPLPCHRQASTVGDDASSTHQKRVHFNRKQNSHDNICRDDYTDEELAACWVTQEERASHYKCFEKTIKRMESGKKANKDNTYRGLEDFLQTDSIDRTVHDCIDAVMDEQKRQWDISFKVIEWDLFREVSREVSTQSAKYSLAMAQYDAHETCAANIAEEDDDSFEGDDFPKGAAEIPQSFKDNANCKHFWHPKKLRSHMQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC62</accession>
    <name>A0AAD2CC62_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1920882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CC62"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1920882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="209" mass="24104" checksum="9D011A4A6F2D3ED5" modified="2024-05-29" version="1">MPPSDDKAKYCYEDPDTWSYLADRKLKNADLLIKIPRRSSIKQNGAPRRVSISRGVEIQINLPGKGDPITRRRSIEFSETNSIEEYKSCEDPFDNIWFNKDEYDDIRSSNRKIVKCVERGTDKNFCVRGLESMMDDVQQVRRRNSIDAVLTEQEAQRDSGVYDEEKLSESYRRTSMASQAQAAGRAETDTADIQLYLQSALMLLRRMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDQ0</accession>
    <name>A0AAD2CDQ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS2224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000125">
        <property type="protein sequence ID" value="CAJ1931075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDQ0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1931075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="105" mass="10873" checksum="3F1A137E9E4EE563" modified="2024-05-29" version="1" fragment="single">MSPKCPDRLLPKIQWKNQDQYVDYGKKLNLIQIGATVPATVPAIVPGASASASGASSVAGSVNTPLRLAGTTGNQMMQVPSGMQLMQIPTQGGGTVTVPYSMNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEE8</accession>
    <name>A0AAD2CEE8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000123">
        <property type="protein sequence ID" value="CAJ1931063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020863">
        <property type="entry name" value="MACPF_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00279">
        <property type="entry name" value="MACPF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042228007" evidence="2">
        <location>
            <begin position="19"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1931063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="33125" checksum="705DF50E6D49FAA7" modified="2024-05-29" version="1">MKFASFIFALLSLSAVKAQSVRGRKDQGEKHASAKVGRAQVEYHSDPRAGGVKDTRTDDRHKVRYGHDQGEKHSRTKVGRDKEPNSDPRAHYPSGDYNSADNDHGTHDPSADYNSADYDYGNQYPSEDYNSTYYDYGTQYPSSDYNSEDYDYGTQYPSEDYNSADYDYGTQYPSSDYNSADYDYGTQYPSSDYNSEDYDYGTQYPSEDYNSADHDYGTQYPSSDYNSADYDYGTHYPSGGTQSGTCDDIDGWVDFVGDGCDWYEKFKDEKACGLCDVDPVGPSGKTACEACCICH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEG5</accession>
    <name>A0AAD2CEG5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000169">
        <property type="protein sequence ID" value="CAJ1931632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="415"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="575"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1931632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="820" mass="91631" checksum="4445445A7BA18BD5" modified="2024-05-29" version="1">MFKKGKQALLRRGKQNEKEPEHLNHSQKASSNDSSHHDSSEHSDKQSADHFADHGTPNDGIQPSPSPEESDFRWSIKPDARLSDGAIGMKSKKQNTARNNKMTMLGATPEGRPHNSSDDSGDDPYLTSDDDNMHLGAPLANHEEVPTEEDPTPVPIEEEEPTTVPIEESPTSEDSIQKEEMAPKKRKKKKKSGISTSSRSSGGSKKRSEDVGISNSSRSTKSKKAKTKKLKKDGVKKTKKKKKKAGEDSEGLEVEAPKKKSSLKDRFRASLAMIGGGSAAQTKDLDKEIIAAIEEDGSEQVEDNDTPDSPLVDSTSVEPETITEKEQSSPSVESETVTEKEKQVSRLTDLVKGGGAPANGEIAPKEQIREGAKRMKAMQTLRSCAVDTHFSAAFSSEPDKSVSAGLMSESDKDTVDKMLAELRQYEIQLEQERNQLIADRDMLQLQQESVEHLLEEETQKAQQLEARVSELENILESEVYRKENEELMMKVQLMETELKRQEDSLAKMVADKQEVMKRQNSTSTERTSSIVSNWDSADLILDGSEVQSEKRSSSLMTVPGDAKLQGELLQLRSSLNHKDNALEEQAKEIAKLKEQLEQSDENQKLSQVEAACEEFRNESKENRSEVERLKKQLAKVEAEKQAEIIKGERWKQLEEEKTKALREAEYEKNEALKKLDTHLLLNLKTTKTRESTINNVLDIGTPAQYATTTPTEIIEETDEIEESEFNDSEKQEKTNWFGRRGKEVEELKGIKKKRLSIEEAEELNWFGFGGDGDDKVQEKDDNAASGWFGFGGKEKKDDRNENSGFFGFGKKGNSEQVIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF96</accession>
    <name>A0AAD2CF96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000092">
        <property type="protein sequence ID" value="CAJ1929789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14350" checksum="31F9579CCD631FBB" modified="2024-05-29" version="1" fragment="single">LSNVIEDFTSKCDTCQQHKAVDRGHGHTAPKEAPLIPWQQLTVDLIGPWTLMVAGQEIEFRALTIIDLVINLVEIVRIKDKTFNINDAKQLVDTAIANAVYAHRCSYHGTITATPGSLAYPYHSTCSSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH70</accession>
    <name>A0AAD2CH70_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000226">
        <property type="protein sequence ID" value="CAJ1932975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH70"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1932975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="559" mass="63604" checksum="1825B30ED6D16779" modified="2024-05-29" version="1" fragment="single">RLLRHPLGPWFDPLNNWNWLWSSAQGLFHRQGHGWQHYRHRRSSTRSLQWDYTCSAQLSGRKRPHNEPADDGTCFLPAPFWTQPLPENVCQATVHITPLLGTLALTGIGTESLQPHHDSQPSLLAAWMAASAEVTECVEWTPEEIEIDGDESLLAEALLEDRLCVISDAYKLGLGTAAVQLLSRKGGKERIIVRCQTPGLPDDPSAYRSELIGLLAGIMVVDWLLDYDNRVTPQKAQFDLVSSIREALARSRASWEPSHVYGHLDKATSFLCLSWWSKRNVEVDAWAVAYRHQLEASHQLIAPNARFFTELAALYIGDVKQSRLNPEHIQELVALPALRKRWHERQTITPEAELETDWTSLARAMSSLPTGVQRWTTKHVVVMCGVGKFKVRWSSADSAACPCCGEFEDHLHVPQCMAPSASAEWDRRTATLDQWLDAQVTDPAIKHAILHLLQELILLGFHMGEHRNSVQHSEDNVQLRERSRLVNDGIHSQFDMGPTDLPKVVQRMLAVKRRTVLNKPLVDREEWLKLVRMERTAYRRALAPQRRILHRFFHPAQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHB7</accession>
    <name>A0AAD2CHB7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000369">
        <property type="protein sequence ID" value="CAJ1934735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="202" mass="22808" checksum="09A8089D194FA2D2" modified="2024-05-29" version="1">MTTPVAISNKSCLCGYDSSSGGGGRMSTQLNTSSRKRTLPGVSSYEDMLMDGMKHLSFDQIQHEQELLHGVADHVDLDDNKINELFLELASHLNRMKKGTAYETAEKQDQSYVSNRELQLAFLRACHFEPRASAEKLIKFFTYKQDLFGESSLVRAITAQDLNQDDLSCLLEGFCQFCPFRSIRTNDPFGVPRRSIKDECPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHQ1</accession>
    <name>A0AAD2CHQ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000402">
        <property type="protein sequence ID" value="CAJ1934869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHQ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042248677" description="KOW domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38365" checksum="1978DD8EC30CBE7E" modified="2024-05-29" version="1">MIQRYSNITILLLCWILRAESFAQPNNKNGRTTRIRQSICSTTTTTSTSVHASLNNNDSSISERRKFLSHAMGAVATMTGISSTTIIMMPSQALAQQPQQPTPGTTSAAVTVPPQEPNKYGVASNKRLGGLSNKIRNICKTMDEMQRDLMQERWDLVEQYPAQLRSYVPLLTAYTDSAFPSEAPSDWGLRVALRYEVGRYFGCLERLKSAVAKRNLSEAYVAYSDMSLHLDRYLRVGGIYTFYDNVIDNEKYFAEYDSALVYSDPIKDPADVRDLVVLCKGPDKGKTGIVIGIYQDGSETCAVKLDRYKGMREIRVVPRNWAAKRLGEQEPDDVFLIPRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ43</accession>
    <name>A0AAD2CJ43_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000488">
        <property type="protein sequence ID" value="CAJ1935590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ43"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="314" mass="36773" checksum="5AABD22991F841B1" modified="2024-05-29" version="1">MISSIKELNEPDWDGLKPKLDLTGQEDEIEREAKKEELKTESVEYHRQKRYWSKAKWHVHSLIMESFVTSKMKDKILQEVNYNEKIEGDPIELLRRINKFMTTSDVTDWEPITLWEALQKWVNCRQKGNETVIEYRKRFEECATTVLSFMGDSWLDVFASKTTAYHEIENNHPTNGLSDREKKRVAAEVEELQEEFQDEFVKLFCAAGLLHNCDCARYQPVLDHFVTAYAVEHVDYAQRDLFPRDVETAAKALHNHRVKKTTTPKHNNTNNTNDKANTPQNGTNLAQDYNKGSKRKCFCCGKADHVATRWEHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJH3</accession>
    <name>A0AAD2CJH3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJH3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="136" mass="16433" checksum="994865A561798841" modified="2024-05-29" version="1">MAMNRQHRKKKALYSFEQARRMARQHGFESKEEFLDYDCPGAYQLPKNPDEIWTAEWRGWRDFLGICWGFEEGRSIAQSLKVDSMEFYLKLFDEKKINESDPASLLPYRPDLQYKKEWRGWDDWLNGNKYGSKLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CK83</accession>
    <name>A0AAD2CK83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-L-fucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CK83"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041979768" description="Alpha-L-fucosidase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62762" checksum="686739C13FF66693" modified="2024-05-29" version="1">MFPSMSSIPLSRRLIVSLSCILGLLFECYNDGFWGGNSRIRHPLTTSLRRRLSDRNVRFLAFGGPSTWGFGLEDPNDSTFSTILSDGHVHNAGQLVSSTAATTTSVPSKLTGNLGGRGWPTLASLCTQSIVGDDNVYDVILIETSFYHFHAPSATFDEDDDSLEEDIQRNYDALGLLASRIRQRFPLAKIIFVQLWDPSEMNYLEENHDDDGYDYDDQYRFKNTIGKGAEKKVVTFDQWRNNQTEVPWRSFWESKEYHQAVKRHDWMLSSRKEDTFDLYLNNLANKIQAFMYKLPRPSDPTEALAKAQKLFVEVEMMDYDRDDGIKYQYALSSQGHRLVATSIRSQYLRNIQSTILQSSDEWRNRVGDWGSGDSCQLWYETNQIDNKKLTYQGLSLRSFSKPMTEPKYALELSSSEEDGGTITVTNPFPESRMVYLTYMTTSDFAFSNKVYPSTKVQVSDKSSVVLDPRHEGKSIQHQIPRTTAIGMIPGNHAQTTIRLETVEGTVSPFRIVGVSLLYESGKAIGSHKIPSEFSLIIEPTHVSELHKYADFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKB1</accession>
    <name>A0AAD2CKB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000446">
        <property type="protein sequence ID" value="CAJ1935295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKB1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="523" mass="58849" checksum="47A0470EA3EB0B46" modified="2024-05-29" version="1">MAFSKSLLVKEEDLNDDGWVAFDAGNDSAFFGSSKDFFANSSSSSIDNKNNRFAAETKEENKEDDAATAKAKAREEERMKAVAEERRQRQAEYERRRAREEQFRLMKEEEMKRNEQEAAARRKEQETQAFLEANTKVNVQEITIVEFSDDDIDEDETAATTPNQSSAAVSTARVVTPTGSPVSSAPSSPDRMVDQSDEEAQARIAEAIRQEELQFHREREEEKRRVAEKERLAERRRLVEERQQLEAKNQKELQEKKRLAAQKKSWLANKRLADRKKGKKKTKKDGSAEKKKSKGSKTRRGWFKKMGVVSEEKTTPAPQEEVVKTEEKLKEEEVEEADRSAIYLHVEDPIGRPKSPTPDFDDGSASDVTGSDFSDSGSESDAGSDSDSDSLETLETKDTKETYTTKGTYETLNTKQYEEFLKQEKKEEGWSSFFCGVFGRATDENDDEQSQTSISTRTKPVGYGSSVAGTSLSKTTYGTDSRATLSVVDDDSDSDSDSSQGFGSEYTGETEELPPMKESSFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CKW8</accession>
    <name>A0AAD2CKW8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000408">
        <property type="protein sequence ID" value="CAJ1934887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CKW8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="759" mass="85217" checksum="D1C445D1D466C7DB" modified="2024-05-29" version="1">MADSLYSESTGDNAEINYLALLEGRYTLPDLLDPATASFLSHCRFHKGHSPVHLQVSKDDHVYFWSRNPENKGSKPHGLHNGHFKAAIQSPSIAYCDALFRNIPLTTGFVPLQWQNLMNFAIEKKPGDFRLSKMRTIQLMNSEAQANNKKAGRAAMQFAKAHSLIPDGQCGSRKRHQAIDLALSKRLVWDLLILQRRAAGWISNDAKSCFDRVVHWVAIHVRTGFGDSKRSFCPPSTVPFQGCGQGNGAGPPIWISVSSVLITMMEAMSYGFECLLALESQLVTAQCFCFADNTDVIEAGDTVHHSGEDICASVQAATTLWSRGFRATGGAINPEKSFWWLIDFEWHARNDDSEHTLGVMLLPLENHNAQEAQLVSKAKEWAKQLWPHLLHKYDVLPLIRTTIMKKLEYPMALTTLNAQQWQDNMSPVLQVCLPKSGICRNFPRLVVFAPVDYQGLGVPHPFGKQVYKHLEMILRHMPGGTKTGAYLDANDLGTAAVQLLPKGGTARIVIHCQTPGLPQDQSVYCSELIGLLAGIMAVDWLLQQWFPALSQRPGVKIACDGLLAIEMAFEDRPLSPTDAQFDLISSIREAISRSLVSWSPRHVYGHLDKSNLFDELTWWEKKNQEVDGMAVDFRKELEAAHQLIPSNPRFFTELAALFVADTKQSWLSDHFIQEFVTLPRLRQHWRNRNVISEESENLIDWETLGRAMRSLPAGLQRWITKHWVGMCGTGKFKVYWGLESSAVCPRCGEFEDHLPSSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLS1</accession>
    <name>A0AAD2CLS1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000558">
        <property type="protein sequence ID" value="CAJ1936800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLS1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="522" mass="58808" checksum="81C37D7CAF9067CF" modified="2024-05-29" version="1">MASNNVSPSQEQRCGVKTGCMYPSLPLVGPGAHVCRGCGEPVHNLCCQAAGFDEIDFVCSPTCNTSSIEASIEESATTRGEATIIKTNWNTVTWDDVVVTQEPVNLVGVESQKTCLCTIKGIPAADLTASDCRVIGKNLKVSSYTRKRKGVLCDMIAKQRLVSQMNMDEMYRQDNNHDRHKRKVAPTTAAKRNPATLPPVVRSSGTIYRFVMTICAEEMRDLVENLGKQPNRQEMDAGNRNGERLYHEIAKFYNNELNSALSSIPMSDINMQDMLELNNIDEDVCGTDYDKLNATDCLNLKKHIDHHYRVAHEKNKMSGNHGDFHNFVGQRPFLYLYHLLMKESSSYTVLHRAAVKGIPADVFRDGGFQKTPSKPPPRSTRSSLSSSGKRKSRPENDLGHSMRMLVDLKRAEMEKNSNDYSSKLRKVEDDLDKNLEKRTANMTKTLKLQEQLNQCSDEHTKERMKDLLCDLERADIMLGKSYRVVEKKRDDILEDARSPVSSPIKRLELCFETSDVSDDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CM40</accession>
    <name>A0AAD2CM40_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS3929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000338">
        <property type="protein sequence ID" value="CAJ1934588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CM40"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="367" mass="41099" checksum="2A36C0D9872C194C" modified="2024-05-29" version="1">MQQGIVDRSGTGATDIPGSYVVRGRSVANERSNGRITGWNLAQVRVRPILKKKGISTEDRGEMLMQKWQAQLDAASTLKDDDSMVSDGSVNMQIYKSTLKMDSLKHCSQWTKDNKKPFKSNGSKHWDIDLGVHLDSGSTFSLPMNEDYAKPGTVSDLDYMFNYARIPCRMDTNIENSFIVTKGEQRMRYEHQNGLYTFVPDGRAESDEESKYSECEYRECGNGDCDAFGVAHTECHKCGVIFCGRILKIIYSDSDYCGIQTVRENIEGFTDKQVERAIRARALYPMAGAPGVQAFRIAVRSGLFKNCNVNEEDAIIAEKIYGPGSSVLKGKTKRPTPEGARDDWIEIPKVLLIHNLDVVLHIDLVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMC6</accession>
    <name>A0AAD2CMC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS6600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000793">
        <property type="protein sequence ID" value="CAJ1939460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1939460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20019" checksum="FA7F56BA27D68ED0" modified="2024-05-29" version="1">MRYIHSTKGWHLTLSADDLRVIKWYVDASFAVHPDFKSHTGAVMTMGTGAVQAITQKQKLNCDSSTHAELIGVHDAMSNILWTRLFMEEQGYPIEKNILYQDNKSSNLLETNGRSSAGKRSRALNIRYFFVTDQVELGNITIEHMPTDEMWADYMTKPLQGEKFGKFQAVIQGDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNB9</accession>
    <name>A0AAD2CNB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS2012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNB9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="2">
        <location>
            <begin position="108"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1930637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="470" mass="51281" checksum="379B7FBF3CE01727" modified="2024-05-29" version="1">MTDRSQENSSQGLLRKTGFFAKTFAADAGNVIGNIGSAAFQSITTRKYTLPDKSVASQVLMYRQLLHTKCRPGLKLTRPYQGTAAQKAVMHMPWWEEGIEQTEKMTISYDNLITRLWLNGAIIPFQESSTESVDTLIDEDGLPPIPHKYWVDRLGFQQPDPVTDFRSGGVLSLAMMVHMVESCPKICERLFSGDASVLPFGITCINVTDMIAKFLMLAKSTDRMDALLSQKPFWKMFADPNAILAVQELAMSMLCDVVVEVSMERKIPSLARQHSTSMHGDSSSEVSVFDFALITERTETRVRDDLLGAGPKTVEEVHAIAGRLRVKYKVQLEKRIERARQQEEHANGGTAPAPQMKDVVGKAAGLAGGIAVGAAGVAGGLVSRFQGGGKEEGSVPVAEEEAPPPIAEESSPTMGFATPPQEDESKDVVVEEVEGDWLGSDNPPVAEPATEPVTDDFAKFSIEDDDEDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNQ7</accession>
    <name>A0AAD2CNQ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000452">
        <property type="protein sequence ID" value="CAJ1935341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="252" mass="26982" checksum="CF7B4917ACCDF453" modified="2024-05-29" version="1">MKEEDSGAILVYRKGNIGCGNANQSVKPGKDGMHPTDVATEWGLFTANKKFFFPMVTILLMGETRFDAPNKVWILKEVGKGYFTFELVETGNIFNTKCNRNAVKGGLVANIFVGGSLGILGQAVAIEQADTVPVLTCFPETVTVGFGVDIVLLKVMLHVKGVGLKFIGNFFMALHFSKGGMNIGRHVGIARVVVLGITTGKKAEKRHCGMEVLLDCGRLDVLSFKGSTGSKCHGVEGKGCDAAFVREVGAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQL0</accession>
    <name>A0AAD2CQL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cwf19-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS8277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQL0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="192"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="322"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1943100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48358" checksum="1CDA19ACF975DD72" modified="2024-05-29" version="1">MLSGIKVGKKKKKAKKVHEPSASSDSDRPEPVSKEPRHGHENDDNQSVADKLRNAIASGKTSVLEDRSASRMIGRLESLPMEAENPSDFAASATVVVSRKISSIDKREEDMTAAELAMNERNMTMPWDEQMVRNAIRTGKKRKKGISGDDSDEELENMKRLLPVDVKEQKAKAAGKATQREQHREVDRYLKQEKITAKCSWWVGSKSFAKHRLLGFGNHLSLVMAPPNLSLIPGHHFHMVPIQHAPSFVECNDDAIWDEVKRFHTALSNMYATKGKGIILLETVLPNNGFWQTKMDVIAVPFSVLQDAPMYFKSSMVEQSDEWGTHNKVMPTSARKPVKSVLPKKGFPYFYVDWGSVSTSENTGYCAIIEGDSFRHDFGMDTLSSIMDLDPIRFNRRRKFSHEDERENIAAFMEGWKKFDWTKDLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CR47</accession>
    <name>A0AAD2CR47_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CR47"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="80"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="177"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="236"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="321"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1943387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="684" mass="78859" checksum="D4EE73E52E622318" modified="2024-05-29" version="1">MKLFIVDSRRRKREFEVKGEDTLLDLKKRLEEESKIPTQCQFVAVRKGRKELHSLTKGDDNKTLAELELKDDDILEYEPFRVHIQHVNWNEGQTVTLDLGIHPDTTVKEMKDMIEQKTNIPAYEQRVVFFQMFLDDPHDTIGANGVEHDDTIDIQDGLTVSVVHKPTGKLLFNQAAEPNDTIHLMKRHIQQTSHVLVEDQNVFWKGQKLTDNDATLREAGILHGDTFEFDNEVEEMEVQIRLATSEVFTIQNINFVTNTVDNLKLRIQEIEGIPKDIQYLDFMGTNLTEPDRSLMECHIYKKGDMIDLTPHRVKLTSVEEMVLTIRLQKGPDRGDGETDSEVLCELTVLPKDTIRDVKKRIQDKTKILMFLQQLSHDGNLLADDRPTLHYLGIKTKETLDLVKLPQEVKVKVVYPPGEKKDDETIVITHLDRMDKLIYVQQKLEKAQGTKVENQDLWYHGKRLTPSGDDEDEVDQRQDTLFDLRIKHNAVLELKIRAKPKKPKKKRKSKVRALSPAPPQKEEKTYDHGGMRYKMNRGDFDWCRINKANKSDYIGLTFKKEGDGNYYVDKIDPEGWVLTFAPYLKEKALVMKFCEKPADTFTVEEMHKMLDEEMVMELETTNPKAIVDNSKFDYGDDFAAGDIVDIDGGPVQGEIRRQAMKGKWMLKNLDTGKVMLVAGTQLTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS05</accession>
    <name>A0AAD2CS05_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041919336" description="Ubiquitin-like domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1943485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="275" mass="28786" checksum="576D38C4F80068A9" modified="2024-05-29" version="1">MKFLSVVCVLATGLLVEAMPDIQVSLRGKKYDLAGVDTVQELQEELSEKSGVAPSKQGRVLFNGKRLSSEDNLTDAGVKDGDQLNIVPKSKSKSGTKKKTTTPSAAASSSSVAAPAAPGGMEDILKGLGGSGMDDLMKSMGGGEGGAPNMQESMEMMSSMMNSPIFKEYMSDPDRLEESRQMILNNPMLKSMMAGMPGMEELLNSPEAWREAMQAAATMYENMDQNDLMQAMMGGAGGMPGGGMPGGMPGGMGGLFDAPNGNDMAALDELSEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT50</accession>
    <name>A0AAD2CT50_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS9612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT50"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF34">
        <property type="entry name" value="PROTEIN STRUBBELIG-RECEPTOR FAMILY 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1945468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="663" mass="69433" checksum="6C87B3078A0680A0" modified="2024-05-29" version="1">MKLKQEVEEGFQSSDSDSEETSSGSEETSDDESEETSDDESEDDSEETSDDDESEEDSDESGESEEDSEETSDDDESEEDSDESGESDEDSDESGDSDEDSEETSDASGSEEDSDESGESGKDSEETSDDDETSEDETSDGDDSDETSDDDETSEDETSDGDDSDETSDDDETSEGETSDGSGSGSGSGSGSGSGSDSDKSGSKSSSKSGSKNASKSASKSASGSDEDDGSEGSGSGAGIAAGAAAAGVVAGAAGAAALSSKSGDKSGDSKSGDSKSGGEKSGTSGDEEESAADSKKSFGFGAADKAAEDEPQFQDFYKTDPEDPERGADPEPSSSFEKRGNKAKKPKKTKPKLDPVAYKKRKQRRQLGFCLIALLVILCGIGIGVGAGVGIFGPATEAPTTGEPTMAPIVSQFPSASPSISQGPTTDLKTDDLTTLIIRASSETTEYDTWADETSVQVKALNWLKDNDNLRFYSDEKKITRWALAVFFYTTNGESTWTDTGKTNWLTDADECIWYIDGNAPACNRDGQFANLNLNQQGVTGTIPPELGVLSDRMEIIDIVGSASQKIAGSLPTEIGFLDGLTELTLQNNGISGSIPGQVGNMKALQTLNLADNNFQGTLPRHLLRGLISLTRLYLQNNDLSGSTDDLSRLPLVDVNISGNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CT84</accession>
    <name>A0AAD2CT84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CT84"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21284" checksum="972B97C62F951946" modified="2024-05-29" version="1">MSDNDDANKIAKNIEEWNVEDSFLWWTQHPFLQNPWNILGISGCTVVAGAFFGYKKPTKKLQKLVDLKKVDAEKLAGRREMGFQAASRALRIATIGTVGTFGVVAVAGFYASGYRSFDALVNDTRAWGEQNRQSFEDWLGIENRPSKTDPEAIATKNMTEEEELNYIYERHLKDAERIPDNSFQKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTU4</accession>
    <name>A0AAD2CTU4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001534">
        <property type="protein sequence ID" value="CAJ1945815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTU4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="264" mass="29891" checksum="1B078A59852C8DC5" modified="2024-05-29" version="1" fragment="single">MRVGFEVEVAAGTIRQYLHGELRPQGYGAGCYESVLQFGDIEKIGALCFYPQEINIRAMEKELMQHFDWKTVIGLRYKWANIPYNGRSKWNERSPGCMMWHVYVRSSDAKRADRELRLWLHPSTPKKDFPWCAVTHYISDWKAAQNGIISVKAVGPVKDENLTMILKHNDFVELTQAKYCPVEIPGMLKQATTKAFGPRTCLSMFLSIKARPVHAEKVAAAEVNVDSDSDDSLLEDISHKFTKVTVKGKTKIKKQSPKSAVAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV66</accession>
    <name>A0AAD2CV66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Menorin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the menorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV66"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019356">
        <property type="entry name" value="Menorin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184:SF6">
        <property type="entry name" value="CONSERVED PLASMA MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184">
        <property type="entry name" value="MENORIN (DENDRITIC BRANCHING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10223">
        <property type="entry name" value="Menorin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Menorin-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1944479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="311" mass="34357" checksum="6F7F2D63F1A28AE4" modified="2024-05-29" version="1">MLPPPKQSWSHSTCTIDTLKNALSDDSITAIESDILMGTVVESSDPSSQSSTSQPIMAHPPDTTSDLSFEKFIKLSLDEGGQLKKHLKLDIKEAECIGPILTALKKRPIAKDSPRIIYFNADILPGPAVRSSKCIEANMFIEKCLKFIQQDGNPQNYAFSLGWKTDCRSFFGYTPTDVAAMQELMEQHQLSEKSLGVVLAVNARVLAKRVGCFDELLKSFPSCQLLIWTGTGEPAISSFLLQYLKGHYESIGYSGRVGFDCQVESNPLKGIFVDVAVKAVSVWWNTKKTFQFTLEALYGASSTTPRIKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CWF8</accession>
    <name>A0AAD2CWF8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001530">
        <property type="protein sequence ID" value="CAJ1945812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CWF8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041937804" description="Right handed beta helix domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="34798" checksum="9E84674401B40EA0" modified="2024-05-29" version="1" fragment="single">MKLSIALFASLMGVVAAQEDCYNTTEALAIAQATDPRSNDVRGVYTLCPGLELTVGFPANEAFTAFSFGGFPLAVLRPNTTIDGNGVVLSGGLIQFATLAAYVFEGTPFTDPKSGTIIKNIVFDGTGLTPAGGFPSQSMFISAPGDYVVSNITFKNIAYGIGDAQSRPIFVGPSDIAQLAPLTPPNSISFTLEDSTFVNVTTSNGTSVFLSENQTIAAKNVIYENVEALAALSVDGATGSATVENVCISGSKFSFATLAAREGDVGLYPSISGLYIADSVENESCAASENLFSSPGRDNSGTCSSVETVDSCFATPMDPTSPTDAPANGTATDPPASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D000</accession>
    <name>A0AAD2D000_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001313">
        <property type="protein sequence ID" value="CAJ1945029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D000"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="81293" checksum="D5B275D5DBCB749C" modified="2024-05-29" version="1">MQTFPPRTLDAILQVGHSALTTVKDLPLDTTKENLLLSNYFHTHVASECKNILLSQAHGFAYFDGADGTLRQVICAKQVGPNLHWASANDSYDAPTPVAFSLDALGSSVISIARDDLARECQARHLHDAQYSAHTALAPDSTDPPEDIHWPSGDGVFTEVKKFFPIYPGANIPPSLKLSTAPPANLESFHPQFRLWYEAMKYLHDHNESQSIHSHAHIFSADTIPTDRFPDSDLATHLTYSPSTVSAFAAEVPTYKALFEEFKRHSALSTLASTNHVTTQEAPAAPLPAGAPFVSELFAQIMANALKGANASTKEKDLARTSASAKDSFSLIFGRVKPVIQLDGSTVNEFHPSVLTDDFATFLEIGSIKEALRHLHDTFAHITDTLTTRNNYDRNVDFDIALFQHATVTALKTCSFAVRPLTMHPHEATSLLSLLAWLPPNKNDVRYTTFLAEGRDIIRQEAMEEDKSKQAAKKTDIFVHGDVSSVEALIKMLANFFAFVKYCVKDFTFDDPPLIVTLLEDFMNALHTPAAKDWIRYNAAVPHLPLCLLLEMNQILQIVVGAAKNKTTQSKLCNGQPIMADTFVNAFSGVTQAISHINLSISMGNLGPYGTCPNLHAILNGKPTPAPKRESPNSRERPDPTKRAKHPPQGTHFGYLTYDGPGRLPIAPFKCKHPITGKQAAFCSHFLFANYHCNRPRCHNIHYTKQFAATMGSADTQAFEKFIEKTPGVTRSAPKPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FC11</accession>
    <name>A0AAD2FC11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1898111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FC11"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1898111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="944" mass="105591" checksum="497E86DEFF0E4FEA" modified="2024-05-29" version="1">MSACPVGFVWPANGGFDEFQNSIANRKKVFLGLLHLMKTRKPIIESWFTAVKDSPASFAVPVVDAMPLWYSFPTKEDLDNDQVLDKALLSPFQEQMDRFLRSHLMQIIYRSASLPTSPLGFKMRARVKMHNMRVSDSFPEALGTTLPAECQAFVNYLFPYEDEERSWDGRVSKWYKLLDLDPGSEVPESYLQYTPRPLPSSAQDPEGYVAQRLPLPSAAPAGLPVDDDMAEFIQAAKRHKPSLRQAPIRTPVPARGDLIVLTEDGHFEDGHGTNYEPPEDHAGTQSFADRQLPAVTPSPLQNRHMGVNHPNSNCFHDATGGNPFAGVMNGTNIPLQSPAQGMPPNGIHNSTWNSPFQQGPRVQIDPTPRGPSPFAGHNTGLPTPGLPTPMHHQQMFPASPGIPSPHMYTASHPNLSYPAGYGSAMYPMGYYPAHPGFTTNKPNLRSKYTPVRTASINSDMERICCPPELKAIGYWLLHPVPPTVGMVRTSLGDRMASDVLQFGLPTEIGRRCLEGFDYKNDGSVAANIVCTAIEYRTKYQFGTFSQVGELQCDLRSVMDSAFIKRSFDIATWWVDPDSAPPPGTSKRFSLLAFLPCISEDFSSDYLPSDGLSWQQMKEFAMVIYYHFALLGSTNPTSDNGDYNDELFCSSLFGHCLRHICQYVLNTNLGRRWAQTPAQCTAAYVRDLSELFHILKKFVDHRIGHDVENYGISDAWPTNDRNAVFMSVPSKTNSAGFMAQTESVVNVLHDYYTRIQRNWGAGRYTAPNECSWAMSSSPFFAPEKAAPSRLLDLPKPKTTERTRDDKENVPFRNTSPLFVWNHTVTPLGKKSPSEMLYPVVQRGTYPLIVDPHAKRTSGKNTLYPICLNSTFEGHCTCSKPGTCKTHKVGRYAGKTRLHIDLNDARWSAATYKEEDWKPIVDFIKKYHDHILPSKAFKKLTPSTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCG9</accession>
    <name>A0AAD2FCG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1916047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="847"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="980"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="860"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1021"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1076"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1110"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1131"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1916047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1206" mass="134346" checksum="2A435B9EE3C3838C" modified="2024-05-29" version="1">MDLPNEQKQVDLASAYYTKGRKLWSKGDRDNALDLFRKALAIQESILGIYNKQTARTYYWVGYALNHKKEYNKALVAYRRTLRIRLFLLGEDDASTEDVKRALRDVLKEQGLNDARVKTYIKTVAAAVEHEKQAIIHEERSEYVEAVEEYEKYLAIEEASVGNFPLDIARIHSKIADIYKLNKKETMALSSYRHALSIFVSKLGRSHSDSQHCISGIEVCASIRGLPASESEQYVELVLESISLIWQGDELKSRGKVDDALNKYEEALKIESMAIGIYPLTAAELHLDIAHCYRRQKEFDRAIVMLRTALSVYIFEHDEEHRSVVSCLREIASTLQEKGCSSADMKKYLNTVSYSVKHERSGQTMRNEGDLAGAITEFQRSLELEVAALGKYHLTQVALYKAIARAYGARGEHSFASSSYRTALLICMKTLGLGHPTTQALFNETYEAAKREGSDCTTIEAYENLVSSSIELQMTGIEQLEQGQYVKAFATFRKAIVAQEEVSGQYHICTSDLYSNVAKALFHAGQDERALKKYRELLAIHQSAFGPNHPSSKRALQGIGETLTSKRVKIEIANEYSEKVIESIAHELTGDSEIKQDLYDQAILSYEQALKTERNLLGESYLTTAGLLDKLASAYRLRGEHHQAILIYRKSIQIYQSYDEPEYGDTQGTLKHLSLSIRSLGFNMSAVERYQHSIQTSIAYETQGDAALLTGNSAKAVSKYQMAIDIEENSLGKLHPTTSSFYKKIADISRDKEDFESALLFYSKALAIQESYLGKDNEETVTTYNQLMNAAQKHGSKSGASLEGWNMLKYVLMGLIGLLVLIITVAKSISTSQRTIKRLNIAAYDDVEDSKDEDPDDKEGDNPKRPLEPPEDRHISRGPWSANSSSYETMSERFDNLPGDSRSPSISRRLAGKSVGGENFELDKSVILKPSLSKEEPSSWRSAKDAIVAPEKTTSLKGAYRKEDDHVGATVVNPIFSLEKAAQRKQLPSRKVGEDGSNPEIETKPIALKVDGMASPLSIKGEVETKDDGEKERESKSPVPKEDGVGGILGDASKNTTDTGGEDSKMKKSPTEGVVSRSSVEEGQTSSGEETIPDVADSEDLMDNQDDKPSVSTETKTQSWDEVLNVPQQSEEVKTPSIDEKIKSQKTLKKKDDKGAGGSLSNMLKKWRNKADNEEGDIEEEASGLDNRIKQWKQAADRASSRHLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FCQ9</accession>
    <name>A0AAD2FCQ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4145 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000003">
        <property type="protein sequence ID" value="CAJ1926272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FCQ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1926272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13297" checksum="D2E9140C96BF5E30" modified="2024-05-29" version="1">MGTVFSTNSYLQYKNDFELVIRATKDLEHLLETQFGAPNGKTVGLHDKITHAEQTAGLSNDTVRKMRRLVTIRNRMVHEHGFNALPDRTQFAKSYDSVEQELKDVLKNRNGSSCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FE56</accession>
    <name>A0AAD2FE56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">snRNA-activating protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS2622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000191">
        <property type="protein sequence ID" value="CAJ1931948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FE56"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1931948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68796" checksum="A62ADCB512C94F14" modified="2024-05-29" version="1">MKRRHTCQESEEKWKQLLTLSQFGTKHHLPMSMPMSMPMGNNKNDDDDDDPQADNNHNNSNNGFFDCQGMEAPTTKTLVDGVLEEFTAKWRALDARRILIDNDQNDNNNTDSKEMPPPPPKRKYRRGGWEHTQEQLLTLPPNFDYTTSNDRPPSPSPNDKHDKVIDLLNPTQHYSYHQELWKLFQQIPTLEDLLDESRANAQIPNSLAVHSEMQKGNQLVHRMDAHALCRLRMSHRHGLPPPPITTTTTTTTCLDDDNNNNNNKMVGTIRFEFWRRQPKRGPGPDPRRMVLEFLSSQTLLDVHHAIVGMTEDDDWTASQKDDTNDAGCFFIEETFYTTNGREKDDDERRANNDENTQNAAMTTANSTVGGAAAANTTNRPDENGTPAATSVAALAENDDNNGDNTGDGTAYNNASATASSNDAGMDYVTTIAQWLDGGGIPNPTRRQYLGIATSNRFRSSTPMKDAILKDIPFRLGVRYYHVMHGDVECSVMVTDKRLVSEPSAGANTNIPNNKTPQQYPIIHDIWVPNYPVPICEACDRFAAVYVYFHRGTPAQKYQDGDPKGLCDNCCKALKLLEKEEARGALQLYHVWKNKFELSTAMVRSEQCRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FF69</accession>
    <name>A0AAD2FF69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1903870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="892"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1903870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1368" mass="151097" checksum="F05253D217765485" modified="2024-05-29" version="1">MADDSLDEFLAWDIAQNKTETAWSSRVSAKSRARRTYGSSRGGSLASQRRTISESDEYIIANDGLSANDEVSEEEEEFGGESSLPPPLPPPAPLLKRANSVTTYDRVRTPRMRRSNSISFAARDDTVKKATFPRRSSMSAQPLGSVDSFSENHHPNLSVLEEFVSPKRPKMTIEFPNRKRVKSEDVSGPKVPLSESFSNLAKVGEDRLFWAKAAATEAALSFNNNGPVAQDKYYEPIEFTDSSPAAESVGSRKRGIWDSPLDDSDEYDSLSGGPSIRRTRFFSPSQTPVHSSNAANTGSLSQMSVNSEDRPRIQEESLDTDDDLSTDDVSVDSQMEAKTPMNDLSHYGNHSIGGLSPDLLDVRNAGPDDIISTMSSYQDLRFLVRSLRKEKSNSRTSWHVAPPVQWESQRRQAFLYWATRTLGFSFRSGGMAITYMQISKAKGAEILELLEMAVTSWKEQGFAEQTPLESSKKLKFTFSSVNKTLGTPRALALTPKESTITSNFNSGNSEVVDDLSSKMMSLGMSDKKKNLRFSDQYMPMGGMILEDSEELSFIEASRPSLENHASARDLMAHMHGLTPIPRKGRPPRLSIESTGSNGASGMSRGIFDDMSPYPKAAQPLGNDCMTPMVTKPDLGWGSCPVSGRDWGASESCSPNIIEELVRRFDQSGIEAGIVDDTMIPQNSWNSSESSSNRFDLELEAAGNEQESSNNSFEIPGDNFGSGLDPILQTKQDRRRQTSFAKHARMSLIASAVNPNGPIVNGRKSLFDRPSRVFLGTDFALAERLEATPAFAPSNDATLDDPACSRRTALADAGVLETILSFLNEPELLCTASLVSIHWADCATQAHANMMLMSVGCASESDTESNDDGSIVEEEMQTCGFMEREWGFLVSNFPWACFLSEGAFKRVYKVFNHNHRVEEAISVMDVNTIESTGNINVVGAELAVSVLLSSLVRRGVCPNFIVTRGIFSCAYEPPARSWGSATNKRPKGSSYVSPKSKRQPKEPAQDKRGRYQYIRMELCDEGDAEEYLKRQPDGAIDPIESMKLLFQMAFSLHAAADRFSLKHYDVKLLNFFLQGVTTEKEGNVVMRYGLGEHTFALKSKHGEGVIAKLADYGTANVDSGSCGQAVTIAQFTTLENTPIDFLILGDSALQGHGHDCFGLGLCMLHLYTGHAPYEEILEEVTCPQGLKKELRLIWENEAESNYSVIRSLILSEVYKDEEGHIIEGEPDESLYDTLYRFLVLFGIPVVSSTLSSSKVWIAIKNTLENKAKKSGGKKNQRNDSTQFSSDRRKYSISRGNNKYIARARKSLESLHGGMDLLLSLVSFDPQTRASALDVLNSPFMTPLREEAEESQYSENDEVFTYNAFSIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG64</accession>
    <name>A0AAD2FG64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000535">
        <property type="protein sequence ID" value="CAJ1936015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="398"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="540"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1936015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="628" mass="71290" checksum="5BA7B770C5E7E4AA" modified="2024-05-29" version="1">MISSSSCFNACGDQQPSAFQSHFMADRGGINSSRKNDNDVEASLVQGMKNLTFDQLQREQEDFHGVADYGAAHREQDPKAIGELLQSLDAHLARIKPGTIYETACMKDPAYVSNRDFRMLFLKGNRYDPKSSAEQMIRYFDVKHNLFGDECLVRDITTQDLTEDDIASVMAGGVQMSSCTDSSGRLISWGFPGVRVIDHVPKKNKLRHIFYYGMDLVSSAEDTTKGIVLVSYQVGQYRESRIDHDLHYEVMQLALALPFNIAGYHFCFSDRAHCMLAHTAVSLMPSHLRAKTRIHFGTHFECQYLLSTYGIPREAFPFKHPSNELDLTWQKYWFQQCQERDQRKLQLQASREQSLSPQSLSSTTTTTTSSTTARQKEIDKHIQYLSSLWQGETPSDDDVLCVGRKVNGKGNERYMALAVLHADAYDNGSPKERRDVMDSIMKEVKKHGRFLKLDTRSESSSVGWIQVSDKEMRYKIAQTFRNLKYRRGSSNTAQSRAILETPGGAEAMESLGQPSSAVSSSRANHGSSNIQIVHQYTPRDVLFGRMKNHTGNQRLRELVQNVASEYDVANRGEKLRLANQLMESVKREGGRFLKPLDSNASQWEVVADKEAVKKVGAHFRNFRRKQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGC1</accession>
    <name>A0AAD2FGC1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000058">
        <property type="protein sequence ID" value="CAJ1928690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGC1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052748">
        <property type="entry name" value="ISR_Activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011:SF1">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46574" checksum="78BD17ED72F37DB1" modified="2024-05-29" version="1">MLLLLQYTSSSFRIAAAFNVVLPRRNSSPRRTSAAGIRGRMSIINMSTTSSPKRPSKFAALMPGEASAAPATGWPPLEFSSTTASIRTSILPDDPCHTNEQPLLHHRREIYYKPSLLSENQVLDLVELLEASSVELREKEARCLVAMEDGDICNTASSKLSEILIPMLMEQVLPFAREVCQAPNLAIADALIRSYDPNDNREALPQHYDKTAYCSVIVPLNPTECEGGLYVQPGASVNTRREVQFQTAGDAVLHRYDVMHGVHVRKGKRYSLVVWMAETEDSVVQKTAPWVEREANISVHAAFLYANNIKEGLLGFSKNETLARSLYEWASEQGHAYSQYVLALWLFKDRQERVRGVDLLRQASTGGLASAQHMLGILYKEGYQGLETNRDLAQSYLRSAANQGYGPSLEILNDPSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGP8</accession>
    <name>A0AAD2FGP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS1916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGP8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF177">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041779173" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="22"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1930366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="626" mass="71903" checksum="1176F348113A9C01" modified="2024-05-29" version="1">MVYNRLLLLLSLVCFSTFTDGVKVRRVKAGKKYKEHEAVHIVVNKVGPFNNPTETYRYYSLPFCHEHSTEEEEVEAAEVENVEIVALESEKREGKLSHKQRFGESMVGDRRETSPYEISFADSVEWRLLCKKLLTPADLKKLKDAIHNNYFFEMFVEDLPMWGYVGDTADEDILVGEVEGSKVYLFTHLHFFLGHNNNQVVSAKVTTDLDRRVDITKEDVNHHVQFSYSVEWFEEPNLTWKNRMTRYAQSRFLPNSFEIHWLSIINSIVLVLLLTAFLTIILLRVLKNDFSRYMELDDDVMDEEESGWKLIHGDVFRFPINPVLFCSAVGVGNQLMLTTFFHLCLALTGLISTTRRGSILAGCVVLYCLTSFIGGYTAVRLFRQMKQTNWVQCIITTALLFPAPCTFVFLWVNSIALAHGSTSALPVTAILTVTALFIFIAFPLTVFGGIVAKNYASADFGAPTRTSKVPREIPTEFPWYRSREFQVIIAGFLPFSAIYIELHYIFASMWGHQIYTLFGILLLAFLLLVIVTSFITVALLYFQLAREDHRWWWAAYVNGGMTGVFIYAYSFYYYFHRSGMSGVLQSSFYFGYMAIMSFGFFLMLGSAGFQFSLIFVKYIYARVKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHL5</accession>
    <name>A0AAD2FHL5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxisomal membrane protein MPV17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS2843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042198363" description="Peroxisomal membrane protein MPV17" evidence="7">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1932452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24796" checksum="FCD1F4065E28FA60" modified="2024-05-29" version="1">MKFVSLLTLCYSLVVVSGFQPNPAKTSAAPAAFRSKAVQSPLFRDPLQVRGGAVPGWAAYNDALDKTPLTAKALTSLVGWALGDFLAQIFISGGPFDMKRFITLSAFGFLYHGPSGHYFYNWLDNLVKGKDSLSVAKKVAFDQIVWCPIFMSVFFTYLGLVNGDSFSTIGNKIKNDLFTACQGSWKVWPIVHAVNFKFISTKHRLVFLNAVQIAFNMFLSIIGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHT2</accession>
    <name>A0AAD2FHT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FHT2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="362"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1932778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="469" mass="53692" checksum="85C86C6B0E66AF64" modified="2024-05-29" version="1">MQQWGSFVNNPVAESSSFDNSKGFLLKQRGRHNHQATMSNEDKQKIQEVDALLSEAMDALTFEERQYQQEILHGVGEDIAEEATFINRELNDLDEHLRRIKHGSMYEVAEKLDAMYVQARDFRLMFLRANRYDAKASANHMLRFFETKQDLFGTDKLAKDITIDDLDEDDRVALRMGSFQMAGRDTSNRQIAVHIPGVGQFKNLQNELRVRFYTTMQALESEQTQLNGIVYILYSVGDFKDGSNELGFMEHIRFALSVPQYNAAIHICFDDPSPCTIIKGGLAVLDARLRARVRVHFGSHVESFHSLSTYGIPKEMLPFTPSYELNMDHHSNWVESSLHSGNKKIDTAPEPDAVTETTPHDVLYRGGIKSSNRGNNHLRSLVAEWSQTYNSGTNDTKRCVVYEIADEIHRVGGRFLSKANGDSPWEAVPMDEVRLKITQMFRNYRRRAKGTRRKKSPPHHGLEDSIFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ00</accession>
    <name>A0AAD2FJ00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000402">
        <property type="protein sequence ID" value="CAJ1934848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ00"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="576" mass="64687" checksum="A1787EDB5C711661" modified="2024-05-29" version="1">MTTGQSKQGRRLPDNVVQACEDRFEEFTNTPGKTGAARRKRRKEIPQEIVVSLEGNWQQMKDGKELSNKEKVGRIRAKLNAMESGMQSGTAKGTVTAMLKEEFGEQLAQLVLSMMDSFGQQPPPPLWSGGVRTVVLTLNAQEQAAVGAAMESLGRRRAEESLKAERESIRQQLKDLKRPPEDAASAHQDVVGKSEEAGVNFAAVASVHNQYLELPNINEMLPLLPQKTRDQASKRLKPNPPADKAVGISDDGEKDELDPPVERTMLKPEEVEKDGLETMQNSQSGLPISARPMSPETRRGSDQLLQLRRPNFLGRTLGKAADEVEKDGFDVVGKSEEGAVNIAAVASVHNQVETWDQALKRLKPNPNPPAGRALGSEVDMDEKMDMGEIDYRRIFDEPDEEQKDIKLQLQALKCAKESNGRAMIQSGLWMDPRPMSPETRRGSDHLLQLRKLNFKERIVNAPKKKNEEHMPTLRLPRGDSFEALTIDPRSMSPELEICEKNWIELQTSETQPFSRESNVLLKNYVVLRNSLETAIPVMCPEAWDQAWKLACAKRRLQRREKMRDRNSFKSFSDELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL28</accession>
    <name>A0AAD2FL28_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL28"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="417"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="58426" checksum="8F96020E6C6C27E9" modified="2024-05-29" version="1">MGSNETPLVLADYGGASCCGKGIIDDNDDASRGSAGSEFKQTEDFLAAEMNKLSFQERNKALEDIHCVGEGLKEDPEVVELHLQEFQKEVEILRPETPVYQAAEAINADYVNDRGFRLRFLRAKLYDVKKAVNQMMKFLQCKEKYFGKEKLCKEIDLSDLTEEDREYMRKGPFHVPKHRDRSGRVILHMLNTRLRLGTAQNLIRVSFYVFWNLLTALEDVQLKGVVSIFYDIQKPGEQSEPFAFKEAIEIMSMALTLPFRYSSRLWCLKPRKKSSLLNNSILAVSTKFFSSYIRVRTRLNYGSDLELQYYLQSLGIPTDEDFPVDTGGNIRQGVIDRWLQGEWDKCKKAPEPPATNPTTIKAVNNVTAAVPNKEETDDMTIDVINNNLPNMRVLPVMGKILGPPMFQPAIIQPWPSDVLFGRGVGCQNHPGNVRFREIMDGYKEQYDNFPRSKRRIVMANLREGLKSSGTRFLRMNKGGYWEECNAAEVDTKIGQYFRSLRKFKKESLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLH4</accession>
    <name>A0AAD2FLH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000990">
        <property type="protein sequence ID" value="CAJ1940983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="414"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1940983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="654" mass="74638" checksum="389129D7756D56BE" modified="2024-05-29" version="1">MLRTGTPKRLWDDCLEHRAYIRSHTALNIYNLDGEVPETVMTGQTANIGPWCDFQWYQWVKYYDKIAKFPDDKMSLGRYLGPSPGIGSLLTGKILKHNRNYHHTSTFRALTSEEMADDAKKRLRNDFNTNVNDKLGDKAKPEDFSEDDLTPTYDCYEDDSGEGLDLMPDRDEQQHDYYDRYLNAEVLLARGDKMVTGKVTGRKREADGSLRGSGHAVPMLDTRTYTVEFPDGAEATYAANVLAEGMYLQCDENGNQFLLLDSIIDHKTDKTAIQPGNDRFRYHGRLVQKRTTKGWQLCVQWKDGTTTWERLSDLKESFPSEVAEYSVATGIDHLPAFKWWVPYILKKRNAIIAKVKSRYHTKQTHKFGIRIPKTVQEARELDRINGNNLWEQALGKEMSNLRVAFKMLNEEDKAPVEHTKIKCHIVFDVKMETLRRKCRLVAGGHMTEAPCPSVTYLSIVSRESVQIALSLAALNALEVKAADIQNAYLTAPLVSEKIWTVCGPEFGKDKGRKAIVVRALYGLRAAGHDYRTFLSEYMQNLGWKPCLADPDVYYMPMTRPDDGFEYYAYALLYVDDILMIHHDAMEALKKIDKAFTLKPDSVGDPDIYLGAKFRTTTLKNGVVAYSLSPSKYVQENVYSAIKNHTQIRVPKQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLR9</accession>
    <name>A0AAD2FLR9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLR9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="809"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1942582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1264" mass="139688" checksum="C87EA0F73C2AB33E" modified="2024-05-29" version="1">MTASQELDLASSSQGIEPSNLALNEGEAQHDDETQPQVPQNVVPTSPAEASEQDAAAFDMRSIHDHPIGGKPPVDAAWDTTKQDVFDEATPAALQNVVVLKSQAFSPAEEKKEQNDDSPLPDDWESVGAGFGTGTPNDTDTDHAETNEASEDVPEEAFSHLSLAGMDDSGEPIVTMDDDPNEMEGANKDESENMKLRKDDEPLLGRQSSSSGVLPEDEESSGKPIIPVEKRIEMYSNMERDEDSSVDSDGANDDDDDESDDNDQPEEVAYVNQNLNEEEEAPMPQQQKDNNDVQEVPQEDTEPEETVRREDAPTFEPAIVAAMNADASGPSLAPTTAETATTKADSPAKKIPLIAPPPAGKLEKWEESKTRGQKYLAAKKYVTPEKKGSPTPQTNSNRFATPEKVKSPGEMSISPSSGGSNRKDQRMAEKIALASSAAAVTFAEQYQPDTIIEKPEAEEEQEGSFVQQSNGMLCGAFTWESADSYGQDSIAKTIRMSTQQRDLFDEHSKQKIEHWFLERVLMVKKSSEESTESLPLRTHLDDNSNFNAMCQYIADCCNGVTVELGMASPTDMAGSTDFSGSSPNSRDSDSSMGDGIAPKRPWLKPMKLTDTLWNTTSGTVAAANFVNFLFLAAKLSKRPSPFGDRNPFIDDLVTNSLTGTEVENTINGNFSPQQLIFEHPRGHAEDIVQFVYTVSLSCESQKEKSALLKLKRSFASSELGIPPRSRSDSLTGFLRAKSGRKSRLLIVPEGHPSPFEASVWNSPRILAAFLSFLGNPVAVCRMKMVNRFCYRIISENQHVIMKDAVRTGGINMNVRPAFWMWVTLQQFNQGQSPPKANDSAYQKCSEEELRELSQTGKDGKWQHVIERDVLRSFGNMPPHKSVARLQNDSIVRALVTWGQNRIMTRGVKGGGEPLPIPHLGSKEQRKSLGKPPRSNTPGNVSSPPWLCSGNFEMDEDALRIDTAVSDWSGVSPVPSFTGSHAESLERTNSRQFSDTGQLLPLDELALGGNCLKGDMKAKLQDKLRFVLHALATSHEGVGYCQGMDYVVAHLLRILQDTVMWKASKGTLPSVISSAPEVKRTSNMEFRDQQQIIQKVENSLVVEEVIFKVMDTLFTTYSLKHIYWPELRCLKTFCRVFERLIQIKLPVLADHFEHHDLNVGLFALGWFQTLFLYLPSMPSATVCHMWDIWLVERSFKIFFRVGTAILFLSQPTLLNNELEGMMTYLNTFPDATLLKPDILIPCALNIKVTNRLLQSLEAEVTASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLY0</accession>
    <name>A0AAD2FLY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS8468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLY0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1943493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="116" mass="13274" checksum="1617FD27EC0D0C58" modified="2024-05-29" version="1">MLLYHSSTSAAELRHCIEDQEEVEASLVDNFGMTPFHILFSSVGTSQGELLDVLLDKYYCSCHTILNLEDANGKRPLDYLVANWTEATKYLYEQTLQRWMVDLMGCLGALFWMEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM90</accession>
    <name>A0AAD2FM90_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
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        </location>
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            <begin position="39"/>
            <end position="63"/>
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            <begin position="53"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAJ1945160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
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    </evidence>
    <sequence length="375" mass="41616" checksum="F15B1E3DE20B3EB8" modified="2024-05-29" version="1">MPSFPRNLCLVILLHLQLANSARPSEAFSLHSSIARSPRISHPSFPRGGGNGPSVPSASSASGDNVGAKLEPIGKALVELAVATWTFTKYLFDHQIRDPKTHIVEPLQQRLNKVLGEKKNEDAVADITTEEDTIDKSFLKGHRVVRLSLVAWILSEALDLMGILHEDTPRLLKSQVDRVWYDVQPKLMDALNLIHEWWSRAMTTENFESIPSKYNFALGTSIGMIVAPLLSAVMGTIARPLILVYSLAEGNAFLQRRGQRGLVDLLDTIHSGIGHGFGRVLERFRRIVRSAMPQPVPIDGALILTTGGSRFDSIRGTLVQQRHYRRSYLFPWRKVQISKALVNSNQDGKGPIHPMVAMIRHGFVVGSAIGFFLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM97</accession>
    <name>A0AAD2FM97_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS9349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
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            <taxon>Sar</taxon>
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            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
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            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM97"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="347"/>
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    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CAJ1945205.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="616" mass="71566" checksum="E1A589EC1EB9E004" modified="2024-05-29" version="1">MSQGRNKRGRAHNSSRFKQGSGHFKSNHHNNHPKRQRRDEHFNRRGADDRQRFKSDPQYGAHKVKIEAQTYHHQVKGELKAEPKSEQALAKPIPDIDFPTKEKNDKACVFISNLSVGVSKEALARFIRHRYIELRIDEPEIVAISIREDRKDCFVEFKNQSHALDAKNALDGRSFGDFGTILRVFPTEKKAWTQYVTDAFTKEEEENKRKQEADRVKAEEIAPEVEDGEVKPKGELSSVQLDYFRNLQKDKEKVRKCLYLHALPQRLSPKELKNFIIEECEKLIHLTPKITACHVRSQENDACVELEAHTEAVMDAIKDRFIEGTSFGVMQWKKERSKRFITYYQEKEERKRQKKAPKDLREHQNQQDLDAPNDTGAATTDSSRSGSGNNNSANASALAEELKRQKEECRRIRKELIKVTKDHQVLNFQYRTVSEEKEQLAKQLNGAQEEVDTTQSELTELKEINSELKGTNTKQEDEISDLRKQLHQMQQAKMNADAEAAEMREKQEKQIHTIKNLEKDLYQTKQLLAKAREEKDDAMEALQGLRVQAHNQGVQVNQNIKKEWIESEKEKGELKRQNRRLQVYNAALESMKEEKDSEIGEVVKKEPVRKKPVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM99</accession>
    <name>A0AAD2FM99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2480" mass="259290" checksum="3E74497DC87688DF" modified="2024-05-29" version="1">MRLYALACLFLALESEVGAFIPRSRPVAVTLSRFATPEKQQEFSDRVFIRVRDRIKNEIVELDVERKKLATEIEESTGLDDNAVQENLKKQAKQLDDKKKRLEQSLQNFEARQQSIESSGGPQPTTAVLAGSVLVAGVAGRNALSNRKIKKEEEKLIKLAKKNGTKAPSGPPPPADDKDNKAKQDGGGGGFPFFQLGTAALIGSALIGAGNDAAIPDQESTAKPIIIQKEQQMSSTQQTPTEQVELPYLENKIQEAEIKQQAQTEAAALIMQARQEAKTAEAQDITKKAKIDDESRIQTEQDKKQQTGAKVNAEEDTRIKAEQEKKLKEEAQIKAKEDEEARIKAEKEKKQKAEEEARRKAEQEAKAKAEDEAKIKAEREKKQQAEAKAEREKKQQAEEKAKADEEARIKAEQEKKMEAEAKLEEEARVKAEQEKKRKAEEETRIKAEQEKKLKEQADAKTKAEEDARIKAEQEKMLKEKEDANAKADEEAHVKAEQEKTLKEQADAMAKTEEDARIKAEQEKMLKEKADAKASADEEARAKVEQEQKQRSAAETKAKADEEVRIKAEQENKQQAEAKAKAKFDEEVRIKAEQEKKSKTEIEAKAKADEEARVKSEQEKKPKAELDVKVKTDKEVRVKDTEIKVNSESVAAAKPGSSEAPTKADTTVPQPGIDGMTPKVAESKQGVPIGSSSAAGVSITRSLSIPKADTTIVSSVSEMIKGSLPSNLLDTSTLKLPKVRIPELPSFADVSKGAADKLSTFEAPKFEIPKLPNVPSSDSIQKEMQNTMEKLRSTQFPSVSAVRSMISGKLPSDFKADVGLSSIFGKNKMATTAIALTGVGIFATASTARSLRIYDETWDERDCIAVLDDPDNPPQKAEFFTATDKTPSPFSPIKEFNRNLSVPTQTDSETLSAQQASGATRQGIPDRSSYERPLPKFGATNDAVNGSSPKGSLGSVSPKGSFGGMNPVNASPSSPFSSTNSAAKTGLSDKDMTKGSLKNPFSESSSFSKGGSFGPKGASTASPFSNEGSTASSTSPFSPKGATAPKTGLGSFSKGGSFGPNGAGTASPFSKEGSAVSGTSPFSPKGATVSNTVSNSFSKGGSFGLNSASVDSSVSKEDSITPKGATAPKTGSSSFSNGSSGPKGASTTSPFSKAGSTVSGTSPFSPKGATAPKTGSSSFSTGSFGPDGGRTASPFSKEGSAVSSTSPFSPKGATAPKTVSSSLSKGSFGPKGASAASLFSKERSIPPKDATAPKTGSSSFSNGSFGPKGASTASPFSKAGSTVSGTSPFSPKGATAPKPGSGSFSTGSFGPDGGSTASPFSKAGSAVSSTSPFSPKGATAPKTGSSSFSKGGSFGLNSASVDPSVSKEDSIAPKGATAPKTGSSSFSNGSFGPKGASTASPFSKAGSTVSGTSPYSPKGATAPKTGSSSFSTGSFGPNGGNTASPFSKEGSAVSSTSPSSPKGAEVSNTGSNSFSKGSFGPKGASTALPFPKEGTSASSTSPFGPKGATISKTGSSPFSKASYGPEGGTKIGPGASSKRPFGSNGVATISPISKIGKTSDTVNGSSTDDDDSPFKTGESTESGTSSKASLGAISFVPTNESESEEDSKEESQDDKGDKTPSEGQQKRKKPYFFSSSIRNGPLSLMFVQDPIPGKYVKGPKTSTADAFETDSKEGETETGFDDPSSSIPEGPNLGDSVGKVLASVTPGTSTSFGGSKAGNKPSAPPPFNKPKSSKGAISKKPETLIDSTDSVATATPSPKVNSKGMTGSTSPFGKTEMPKEFGGPKKGIQESTSSPPRFYKIESPHGSHHKSDIPDEDSGASSTTMPFPKLNNKGMKGSTSPFGKTRTPAFGASSKNSDSSKDDNETAATTTPFPKLNSKGTKGSTSPFGKTGTPTFGGSSDNSNDDNETAATTTPFPKLNSKGMKGSTSPFGKTGTPTFGGSSDNSNDDNETAATTTPFPKLNSKGLKGSTSPFGKTGATTFSGSGDNSDSSKDDNETAATTTPFPKLNSKGLQGPASPFGKTGKPAFGGSAKADSKGSASPFGKTGTPAFGGSAQADSKGSASPLGKTGTPTFGGSANTGSKPSSSSPFTNKMQSPKGSMSESTTRFETSGSKPKPGTKWSSSPFSKGYVPDSPKLDNESSSSTLSEDQLLETEESFETSDDSESSGPSWYNSPVTTDWGKDDDMMMSESPEMRQQSPPPQPSKAPPAELNSQSATSFSKQPSPKPKAIDQMPNNIMSADTATSSNQPEMYALDADGGDSVQWWQIRQQDWGLEEESKSAFAAPPQRPQATPKHWDPHGAVDEPVDIMTKYSSSNGEWWSRGKSDTTMNPDPPILQSYSSSESSTQELPVLDVAPDEEELSNDADIAEEQESAVPKLPDRIDDKAEVHLTPVNPNDPTASQFESDSTRPSTSLPPATNTNTNTDDTTQDTKLIPVNPNDPYDKKFNNDDTLTPVESDQDVSDGSWYNSPIDSSFFSADRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FMF7</accession>
    <name>A0AAD2FMF7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS9769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001446">
        <property type="protein sequence ID" value="CAJ1945625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008716">
        <property type="entry name" value="NodZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05830">
        <property type="entry name" value="NodZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1945625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="2273" mass="256553" checksum="5D4E76F7E5F85A47" modified="2024-05-29" version="1">MQTFPPRTLDAILQVGRSALTSVKDLPLDPIKEKLLLSNYFHTHNASACKNILLSQAHGFAYFDGADGTLRQVICPKQVGPNLYWASANDRYESPTPVAFSLDALGSSVISIARDELARECKARHIQDTQYSPHTALAPDSANPPEDIYWPSGDGVFTEVKKFFPIYPGATIPTNLKLSSAPPADLDTFHPQFQLWYEAMKYLHDHNESQSIHSHDHIFSDDTIPTDRFPSSDLATHLTYSTSDVSAFAAEADTYKNLFEEFKRHSALSTLASTTHVATHEVPAAPLPAGAPFDSELFAQIMANALKGVNASTKEKDLARTSASAKDSYRLLFGRVKSVVQLDGSTVKELHPSVLSDDFETFLEIGSIKEALRHLHDTFAHITDTLTTRNNYDRNVDFDIALFQHATVTALKTCSFGFKPLTMHPHEATSLLSLLAWLPPNKHDVKYTTFLAEGRDIIRQEAMEEDKSKQAAKKTDIFVHGDISSVEALIKMLANFFAFAKYCVKDFTFDDPPLIVTLLEDFMDALHTPTAKDWIRWNDKVPHLPLCLLLEMNQILQIVVGVSKNKTTLSKLRNGQPITIDTFVNAFNGVESAIGHLNMSITMGNLGPYATCPNLHTILHGKPNPAPKREGPTTRERPDPTKRARPQPLGSHPGYLTYDGPGRLPIAPFKCKHPITGKQAAFCSHFLFANYHCNRPRCHNIHYTKQFAATMSPTETQSFDKFIEKTPGVTRTAPKPHVPQCSTCIVRTPSSMIRNPINNSLSPPHPSRTTSTSTQPTGTLSNAPSHTPSSSPPSASSPDSPYPRYTDAEQEKFGERLEVAIQGRSSIPSTTKRDREAWATTKLPSPVFLAVNSPHGKDSVDRWFSTQHKFEHTWIFLLKSRYLSPTDMATLFQVCPSIHLLSLLLDEHRFVDFRPLRQPIPTHLPPDVAMHRWSRMFTACLLHYDLSIPTAVRFVGNIHTGAHRDWPTLEPILREAKVDPLLITQLKRIFLDGAPNYVTAESSDDNLRTFIAYGNHKTVYDDVKKTKSAVEKDVLRNYLLAANPALLPYIRDAHTTPLGLVDASHEYRKPRIIFDATHHPSLAAMAVNDFTSKDTEPDICFPRSFPNFLIWIYNLRITYPNEEIYICDDDVSGAFRHVKWNPNVVGMHMFMLFGFLFFCTGLSFGDNTSPAQWEVVALVRQQLAQSLWYAAATTIPRVAKYLPTLSLAPLPTPSDIAAFTPAEPDSKNPGVLQPDGTRKSPTFDHHVDDCLYADVALFLRQTISASVLALYILLGYPNTSNGIRDCISWEKFANTFSHERKTIGWVVNSRQLTVSLPPIKRDRLLKLLSETLANPKLSLRDIAILLGHVSTATTVCRWMRCSYFNLQRVLSQFLRSRHQSIKHYMKRNDKVQIISDQLPPALSYRLASLIGKEAATFLWNANKRFHLDASVTRELRAIQHSLKTETWKIYIPQMIPRDPHFTSFGDASFIGGGAYSEELLFWFRIVWSPDIVAGTKLKSSNPNYVHINSLEFLVAFLQEVATVVRLEGTSHAHAGLVHQFPNGFPHFPVLLNRTDNTPTEKWMNDARTNSPFARLLVDLHGQLLKRSPLTSLSDHVPDISHFTLDEKLRLFPAKSRTLLRPALLSILQSKAGAADDPRKFGTLRSRRLHFLKFCYDMNLRDDYLMNGPDFPHERRVATFALYTVALATGRTLQGQYIKSATIKQYLHAAASFICLFTGRDPRYNNPSDTKMSPDIHATLAEVERHEKVPNKLEPYTLDMQQHLEQHNLDTKAHHDGIWKTGRVLTPSNQSAVLTSYFQCRHLTTMGSATNRLMGAFAVVLLLLVSINMKVLSMNAVYDLKERMGDNVMENFKILPANRLVHVSRAGIGHRMVRDTSAYHLAKGLDLARLKLQWGSCSKDTNWKGNEGFDELSIFPHLFGNDLWNVPGTLSGPKREGKKVIARNDVYGYIPGESYKTYHIPIQREIYEGEDGPFFDKLQSDSEFYDKLVDSYMFKDEVEAFMEEHNFAEHEVIGIHLSAGNGEEKHKIEDERKFMKNILYLVSQYVRLMKMLYHDRFARRTPLIFLATDTPRLIPEVQAATEKFGVKTVVLDQIRVEDNEGVTYKALAGKEETCLEGWKAMTSDMMLLSHSDVVIAARPSAFTQGLPLSRVFDKHVDEEGPHYCEVGDDGNYMSCLEDKKTWLFRDNIRKVVPISRSQGINGLFDPEFPQVVHNLLIQLPDVVHPNEFQEVKKFLDGKRGENQGDILKHVYGEKAIFGKYKDNLKHEPKWNFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FNM1</accession>
    <name>A0AAD2FNM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS11109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001725">
        <property type="protein sequence ID" value="CAJ1947363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FNM1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10590">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041417">
        <property type="entry name" value="NPEPL1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF48">
        <property type="entry name" value="DIPEPTIDASE B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18295">
        <property type="entry name" value="Pdase_M17_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1947363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="555" mass="59322" checksum="A20F25E0C84220C2" modified="2024-05-29" version="1">MVQFCLHVNDLFAEPPKPQSSGIDSLILIGTKAGYEKHFDWACNSILEKILSNSKGNSKPKSKKQKTEGSAAAQELLRTLLSGLNPSPDSGNATECYFPKSDGNGPPLRVVLGVLPSVVSRHNSPGQPYAVTSLLKKTIRFKDVTVVAPLCESKDHWFSVACAIARVGGPFLYNSKTSSSSSNGAIAKNKIDFQTDLSQSDKAVKVVFTESIDATTQQKFALLALGIQLSRRLVDEPPNELHTTAFMEQALGLIRGMEHVSSKVIQGEELDKQGYGGMYNVGKAGPHPPALVILSYEPPAAKGKKSTVMVGKGVVFDTGGTQIKTKAGMPGMKRDMGGAASVLASFLSLVMSGAVQNQPLHAILCLAENSVASHAMRPDDVISMHSGKSVEINNTDAEGRLVLSDGVSHAFQYLSPQVIIDMATLTGAQGVATGKYFGALYCNDEELEQIAVKAGKSSGDLCHPMPYAPEFFRPEYSSAVADMKNSVADRANAQVSCAGQFIANHMGSFLEDGGKWVHIDMAYCVFDKKDERATGYGVGLLYSIVQSIESNIMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPJ8</accession>
    <name>A0AAD2FPJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="7">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CYCCA115_LOCUS11297</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-binding protein that binds to both double-stranded and single-stranded DNA without significant sequence specificity to reversibly repress the transcriptional activity of chloroplast nucleoids by promoting DNA compaction and possibly regulate DNA replication.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Essential protein with sulfite reductase activity required in assimilatory sulfate reduction pathway during both primary and secondary metabolism and thus involved in development and growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] + 3 H2O = sulfite + 6 reduced [2Fe-2S]-[ferredoxin] + 7 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Interacts with ferredoxin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Plastid</location>
            <location evidence="5">Chloroplast stroma</location>
            <location evidence="5">Chloroplast nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPJ8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042644">
        <property type="term" value="C:chloroplast nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016002">
        <property type="term" value="F:sulfite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000008">
        <property type="entry name" value="Sulfite reductase [ferredoxin], chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000014">
        <property type="entry name" value="Sulfite reductase [ferredoxin], chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011787">
        <property type="entry name" value="SiR_ferredoxin-dep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02042">
        <property type="entry name" value="sir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0883">Thioether bond</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041931453" description="assimilatory sulfite reductase (ferredoxin)" evidence="17">
        <location>
            <begin position="19"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrite/Sulfite reductase ferredoxin-like" evidence="19">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrite/sulphite reductase 4Fe-4S" evidence="18">
        <location>
            <begin position="244"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrite/Sulfite reductase ferredoxin-like" evidence="19">
        <location>
            <begin position="410"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAJ1947765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="631" mass="70730" checksum="F54D5C7D8E509112" modified="2024-05-29" version="1">MKFLSVSVAALIAGSANAFSSRSAFTGVKPMNVAAAADGSSTSLQMVLEKPATKKISKLEQLKVASGNLVKPLMEELYTEEIGISKDAYQILKYHGSYQQSNREIKGKDYQFMLRLKQPAGELSPDLFRLLDDLSIKHGQGDLRATTRQCFQMHGIMKGSLKTVISSIMNIGSSTVGACGDVNRNVMITPAPFTTPEYDYAREYSKVFAHLFRPMTPAFSEIWLDGEKVATSEVWAKEVEHHNVDEKMLYDSGRGIILDHPIEPIYGDRYLPRKFKIGVTVPGDNSLDIYTNDIGCVVITNDQGELEGFNVMVGGGMGRTHKKENTFARAADHMGFVPKEDIMECLKAIVAAQRDHGNRDVRANARMKYLVHTLGIDNFRTLVESYFGKKIQPWREMAEWKYNDWMGWWEQGDGKLFYGLHVDNGRVKDEGNFRLKTALRVITDKYNLPMILSPTQSIIFRDIKPEDRPGIEAIFAEHGIKPLEEVDPLSRLAMACPALPLCGLAQTEAERIIPSYIARIRALLDKMGISDEEIVMRMTGCPNGCARPYMAELAFVGDGPNSYQVWLGGSPVLTRTAYPFMAKMKADDLEVTMEPIFDMFIKQRQEFEAFGDFCHRAGAEAIEKYMESYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRT3</accession>
    <name>A0AAD2FRT3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001779">
        <property type="protein sequence ID" value="CAJ1951082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRT3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1951082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="224" mass="24274" checksum="092E45503B706525" modified="2024-05-29" version="1">MVRGEGSYAEFEDVEWKACSHVAVARMEEDDDTAVSTEVTTCGPPLALKLSIHCPLPHTGTESALFLNGQDAALIRASSIPDATGQVVLHMANSQNVEWKAGSLAAVARMEEAGDAVASTEVMNCGPPIALKLLQKDSFAIMMDQERSKEKEVAIQSHPTILRGILRIIDWSERRFYKKAKLPSIDGPSGLTLNGNEQDIVLEASSSPGLETVRLTFPTITIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSC0</accession>
    <name>A0AAD2FSC0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS13259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11715">
        <property type="entry name" value="THUMP_AdoMetMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054170">
        <property type="entry name" value="RlmL_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47313">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47313:SF1">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22020">
        <property type="entry name" value="RlmL_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041939398" evidence="4">
        <location>
            <begin position="23"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="RlmL ferredoxin-like" evidence="7">
        <location>
            <begin position="62"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="THUMP" evidence="6">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="5">
        <location>
            <begin position="241"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1951830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="516" mass="56229" checksum="2AB60724A13EB33E" modified="2024-05-29" version="1">MAHCRGISFFFAVWIILPLANGFIINPPSVSRNSKTSLSAGSSHIAGEAHSSLSSSAPSSYLATCIPGLAPALAEELEGIHPEITDISQSGNAAVTFTATREASLNVLCWTRTAHRLLELVAATNQEDQLYDKNDIHTFINQEVNVRDLLGDGMGGLLTLSVKAILNNSRQLPKDLSHSHYTALSIKNALCDVVRDMRGDRPDVDIDNPDVPLVAMLRGYNGGASLSLYRSLHPPGSLHKRGYRQGSAIHKAAMKESLAAGLLMEAGWKGRVDAARNGHDKKSNICLIDPMAGSGSLILEAAMMAADISPGLMRIRCQVPGQSSPPVIRWKSELDTTKLWKEILLDASNRAKTGLEWIRSDQTQLVLRANDIHAGAVEILEDSAEAAGLLTLIDVSSMDCFDLQMNEKDASCLVVTNPPWGVRLTEDVTMSWDALRHFLRDVCPDNTEAWVLSGHKAATASLKLKRNKMVPIQTGDQDLRWVQYIISSNQERRKVHKTGKQTLSTSTSGDRGDDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT90</accession>
    <name>A0AAD2FT90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CYCCA115_LOCUS13658</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001812">
        <property type="protein sequence ID" value="CAJ1952660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15614">
        <property type="entry name" value="PHD_HAC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031162">
        <property type="entry name" value="CBP_P300_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51727">
        <property type="entry name" value="CBP_P300_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAZ-type" evidence="21">
        <location>
            <begin position="466"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="21">
        <location>
            <begin position="704"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="20">
        <location>
            <begin position="952"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="CBP/p300-type HAT" evidence="23">
        <location>
            <begin position="1192"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="22">
        <location>
            <begin position="1593"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="21">
        <location>
            <begin position="1661"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="55"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="354"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="428"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="549"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="789"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAJ1952660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1885" mass="212358" checksum="539E4DD6861478F6" modified="2024-05-29" version="1">MTGVQTKERKHNIKLPNISRKTHQRVTASKQQYLELRKAKATIVAVSKMMAPFDGSVQQQQQGVSQASLPRPPMPPGHAGQQPMNPAYTHGLPRGVAAGIPHAYQMRPQSPGSRHDSFQMPSAGGPQGQYTSHQPLHSPGHQQQPQGGQIHPGMTQMHRGSSQSRNGHVLPMQQTHDNIMASTNGRNQQFMGSSMGGGMDNSMNNTLNNSMNTSMNGNAMMSMGNPVNMMGNSMNAGLPNMTMNPNMGSVGVMNVSNGSMRSSSAPMLNSSMHSGGGMHGSWQTDRDTQHRRDMIQHIVKMLKKDRNGSPEWLSKLPQMAKQLEVSLYRNARSFEAYTDMNTLKQRLQQIAAEVSKKARDQRDDRQRDRIPSSNNKNTNYIGMTSSNTSIQSNSIGPGSVANNNPMLDMNSMRGSAHTQMRTVGGSNFQDQRAATSSNRTSASHGMGNSLSSGTVLSSSGSSNRNDPEWRVRIRHKQQRLLLLHHSAKCPHEDGRCPVTPHCADMKRLWKHMEGCKDNQCRVPHCFSSRAILSHYRKCKDVSCPACGPVRDTVRRSQNRNTSSSNLSLGQNRQSRTNMGEEVQRMGADGNTSAHPPLPCRANSYQPSLGNSFNQSQDPKPLMPPSGNMSKPQYPSIQSSSQNAQSSGTNNEVVGGQSLHFCQGSSVDSGVVDKGARETPNGNSWVGERQQDKGPIPPTRRNDSEWQKVRHKQQRLLLLRHASRCQYKSSCPVTPHCASMKKLWEHIAHCKDQRCSVPHCMSSRYVLSHYRRCKDARCPACAPVRDTIRKSHEKERQGQSAGLTNSFDTEKQGDSSTTAFDAGFADSSEISTSDDNQRSAKRSRLDQGVSLSVAPSVTDGLSENASNFDNSKKKETLSNERIGVKASQSLEGLQKEPIPNPATQNAQTSEDRSLLNSFSVAQLTTHLESLNRVAQLSPAIIKQKCLEVLKGLQAHQHGWVFNSPVDPIELGLPDYFEVIKKPMDLGTVSKKLDSCAYHEICDFQRDVNLTFDNAMRYNEEGTVVYGMAKELKDKFEEDNEELFEQLKAEDWVRRQNDRACVLCGCEKRLFESPVFFCNGLNCQSKRIPRNRYYYIGGNNQYFWCNQCYNDLDKNTPLEFVDLTVNKSDLKKKKNDEVHEESWVQCDVCEKWIHQICGLFNTRQNKEHQSEYCCPLCLLEKRKKGTSATLPLRPPGAADLPRTKLSEYLEKDVTKRIEEKKQGSTGNAQSINAGSVIIRQVTSMDRKHEVREKMKSRYKYKNYPDEFPFRCKCIVVFQHIDGVDVILFALYLYEHGEDNPAPNKRCVYISYLDSVHFMRPRRLRTFVYHEILISYLDFARQRGFATAHIWACPPLKGDDYIFYAKPEDQKTPRDSRLRQWYIDMLVECQRRSVVGKVTNMYDLYFANDSLDATAVPYLEGDYFPGEAENIIKVLENGGNKKGGNAGKKMAGSAENRKSTVEIERDQVMVKLGETIKPMKESFIVAFLNWSEASKESMKVPEVVLKYRSEHPEAMVPLLTGRKRDADGNTRELDRNGRPMKVIDDDVEDLDCEFLNNRQAFLNLCRGNHYQFDELRRAKHTSMMVLWHLHNRNEPKFVQQCVHCNREILSGMRYHCAICSDYDLCEKCYKDPKTNRGSCTHKLHPIAVESEGAQEGQGNSNGVTAQQRKQRQGNLLLHIQLIEHASRCSSSSCTSTNCAKMKKYLMHAKTCKIKVQGGCRICKRIWTLLRIHAQKCKDEVCPIPQCMVIREKMLHKCVPDEWVNLVLYLMKTEFWTKDRQQASSAEMIVSFFEATEKAARREIFGTITEKLSVRMLLYGHSIARGIFGCKNQDSAGSQRLPLAYKCLQPLVCPLLVWSGMVEDSRDGSHGVMSGYLLEPTLLAKALSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTA9</accession>
    <name>A0AAD2FTA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vms1-associating treble clef domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS13424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTA9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041540">
        <property type="entry name" value="VATC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819:SF3">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18716">
        <property type="entry name" value="VATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vms1-associating treble clef" evidence="5">
        <location>
            <begin position="410"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="4">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1952186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="458" mass="51009" checksum="6319F145694F4359" modified="2024-05-29" version="1">MAAEEQNDKAKAKTMTVLGPFDVEDTLFGPVMMYEKIISNPASGQSMVTSSSDNTTSSRQVPFTMENLSEIRSSPFQYLENMLLNSENEACREIRHLSDGVANDVKVVLLDMTTAKEGRDHKACQRISQQLGIHLLIGTTCPTEHPDMDTTNTNTNTNSTAMDGFQRNMEHMERELKYGIGTRSEDDYKNLTSPDSKIVRCSFCGPMHISEGFPVAEQNELKAYAAVQGGSNAPLVLVAPSLTAVSGILDFVTNSGGIVSKTIVAHADLLLHRHAQQTDMTLALQILLEQVLDRGAIVCFDSYSVSACAFFDFDQDFPTLASVVDTASNLLSKKAKYAEQIVLSAGIMMKLQLKRYGGVGYPVVLKELVPRLKKKEVITSEHIELMLNKNPRRLLQWWVPPPTPEVPKYYLTCSICKKKFEPIMGEYFSKYTFVYCGTKCLRKHRKVGFKPLEEAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTB9</accession>
    <name>A0AAD2FTB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTB9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="80924" checksum="4CAAE9F23E4088B2" modified="2024-05-29" version="1">MKPGVSRLSTVKSPGGNSKSRFKSFKRSLLSFVRSPAPKEKTERRSFPTPSTTRTNWECSSPSETPNSISTRKAHTVRPSSHLPPPPLFDPSVSSTTIDASSEPTLTSQQQQQQQQQQPKRKQRVFKDGKLLYEWEQNSTHVTMRLPAGWTLGAQNDNVKVLIAPSFLQVGRIHKHHNNSQKARIEWKLHHTTGGTIHVEGSTWTTPEEHQIPDQGTIITLCKAKAGVNWGYALLHHAREEVQTKLCRPPRTKQRRPKTQQQQQESKPATVEQVRPSVTENDDEEPIKSPGLKKKKKKRVAKKKKATKISSADLEKPEEPQEESSYFQEKQKSTRRSGGEYSFKTKPQAKERKSSTSTHSTKPLFGDDASGLSYPVSPTTKRSGGAYSMKPSSYNRLNIYGDEKAEQPASAKSMMTDYSESSISLDYPVSPTTRRSNNKESIHSQNALDESRPSSCCYSLTRESSTFSILESPKRFSKPTSRISMEIKSPTNKSGSSSRSIDKSSSSTRSLSNGNKPASRISQQLKKRISSPKKKKILVPSKASKMDQRESLLSKSNNKRKSSNSESLDFVGHSSEVDKAFPHKPYPNGQRTSVSSCQQQQDPEMDQAQHHCKHNPRRKSALTKFLEKPSTHSHNTGNGSNFKSVMTANTNTAVVVQNMLQGWTTSGREEASKANDIKKDIAPKDESFSDGFFKNHQDAEEWNDDDFLQELEMSYSRTVSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTG7</accession>
    <name>A0AAD2FTG7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001814">
        <property type="protein sequence ID" value="CAJ1952943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="110" mass="12184" checksum="D9C990DA6262433D" modified="2024-05-29" version="1">MIVTPGTRRTCTAETKKAIADCAVAFDSEDEDDYYCDDVSASALKPEIANLKARISDLQEETMADAIERLVQRNGKNVELPAELLIEALNKPLEPSNSMSNKSYRSSPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTL1</accession>
    <name>A0AAD2FTL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001815">
        <property type="protein sequence ID" value="CAJ1953071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTL1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31176" checksum="11B1D9BA78E9183E" modified="2024-05-29" version="1" fragment="single">MGRMHLSQVSHRAKESGSDSTGLGRWAYVRLQGKKLKTQGGDDPSGLVLDVNKAVRRSISRDLVIVLAYRPNREGTGESTVWAQQRLYFNSIKRKIDPRKTLVDDLCKQIQKWRDEGCEVLLGINANEDLSVNSPDSIQQRFRECGMEEAILKRHPPTPTHQRNQSNVPIDGIFTTSGVPVLAGGYYAFGEFVESDHRALWIDIDLNTALGNFTSQGSTFKPRKLTLLDKRSVKRYGVGLIRLVQHALEARPIAVVEKCACLECVQNFFLELVLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUL5</accession>
    <name>A0AAD2FUL5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001841">
        <property type="protein sequence ID" value="CAJ1953800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUL5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="235"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="726" mass="83165" checksum="B255C9C5ED3A894F" modified="2024-05-29" version="1">MRIRIHWQRPNKEADESRAPVPTTGQDKNGTKSSLERQKQQHLQPEEVRAALHAKIKRQKVKRKSKQIPQKKSKKRKIQNGSRSTSTEDVINGDSISGNNFPEGAKAPSSTLSEGEESPEGAQAPSSTLSEGEESPTPVQRSAITAATILDKRRKEMKLALHTYYTSTARRIHANEIADESIASNPMAFSATLADEDTMYLHQARKQKDWKQFSEAMGKEIQDHTEGKHWEVIERTKVPEGHKIMRGVWSMKRKRRVATGQIYKWKARLCVDGSSQEKGVNFWDTYSPVVTWESVRSLLTLAIMNKWTTRQIDFVLAFPQAKVECPMYMEIPQGCNVDGSRDTHVLELKQNLYGSRQGSKIWFDFICKGLRKRGFKQSKTDKAVFYKGETIFILYVDDGILIGPNAGEIDDIINSLQKDYKLTDEGDLNEYLGIKMERCKDGTRWLTQPTLIKRILKTVGVNEQRPPGKRLMRTPATKVLHKDISGPPRRHNWDYRSFVGMLNWLTRSTRPDLIFAVSQVGRFMAFPKKSHENAILRICQYLRDTQDKGMLMRPQRTGFQVYADADFAGGFVKEHTADPNTAKSRSCYFIMFNNCMIFAHSKLQTEVALSTTEAEYICLSQSLRTVLVQMRFFKEIAKRIKSFCYTKPVIKCTAFEDNKGAIKLAKAPKLRPQTKHINIKYHHFCEAVAHGLVNLEHQTTRWTHIRIFVTTPYRLVMPALKRECGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUU7</accession>
    <name>A0AAD2FUU7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS14326</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUU7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1953723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="330" mass="35604" checksum="661277A62426E6DF" modified="2024-05-29" version="1">MKGAAFTFDFLAQKEGAANNGPSNPLTGQNGADSAVPKETVKSFAWVENIESRILNAFDSGWALYQYEEVPLSGEAYVRSVRESISSRKELQGTDLVPGIYEGGLKVWECSIDLCRYLVENDIDIEGHVLELGCGQGLPGCCMLKRIAERLSSGDQEKTSLVGGTAPFGVVFSDYNEFVLTDVTIPNIALNVRDSLERTRLQSLSQYVTMGFGDWNAMSEQLLSKSSACPPNIPQDGLFDMILAAETTYSSQAASDTAFLLAKHLKVNTGVAFIATKRYYFGVGGGSGSFNAALSSVSLPNVEFNVETLMVFDNGAGNIRELLKVHATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWI0</accession>
    <name>A0AAD2FWI0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DETOXIFICATION</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS15343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWI0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893:SF46">
        <property type="entry name" value="PROTEIN DETOXIFICATION 44, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PROTEIN DETOXIFICATION 44, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042141296" description="Protein DETOXIFICATION" evidence="7">
        <location>
            <begin position="27"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1954751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="58115" checksum="27D590C8EEEBB925" modified="2024-05-29" version="1">MKFYSVAIPSLAMILVATSLVREAQAFAPPRIVASSITSRTPGFANLRQSIRYDRINGEVEDDTSTTLQSSASDIELTSGKRRFLDSLPRIGRRKDELDDNILKTAIPNMINLGVVPLVNAVDTFWVGRLGLALALAGQSAANQASFTIFFLISFLPNIMTPLVASAVASGNEEEAQRRVCESIFLCTTLGLLGTGLLVAFPKQVLSALVLPGDAPAMAYAAPYLRWRAIGMVPSLISATGFAAYRGMLNTVTPLKVSLFTNAMNLVLDPLCMFGGGLGFLGAAVATAASETLGGLTYLRLLLRKGLARWSILLKPPSWKSLLPLLQGGAAMLFRQLTLNGAFLIATRRAQVMDPTGISGAAYGIATQISNVGIILMVAMQSTTAALVPASMAKEGPASARKCADRLMIWSTLMGIVLAVVQYASLPFIVPIFSTLPEVREAVKLPAFIASLTHILDGPIFAGEGVMMGLGSYRDLAIITGIWALFMVGGIMSPFGQRLDGIMWTIFFASIIAQISTVGHYLKIGPLANLKKKKEMEMETAPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWL7</accession>
    <name>A0AAD2FWL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS15268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWL7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042003233" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="47"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1954677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="489" mass="53326" checksum="B6A14450717108BA" modified="2024-05-29" version="1">MRHWIVTLALFVISSGPVKSQNGLRREKSSKKRQKPVKKHWAFQSRIIGGNDAPAGQYPFFVQWHGCGASLIHEDILLSAAHCDLIEYNDVIIGSHLRFDDTVPGAQGRMIVERRIHPNFNDTSMENDYMIMKLDSPVSITPVTLNQHASSPAAQEMLTVMGFGLEEEAATGGSDTLMEVNVKAYSIEECDARYGREVTEENMFCAGTTEGGKDSCQGDSGGPIIDEFGVQIGVVSWGYGCGHADYPGVYARVSGSLDWISEQICDLSDTKPGSCRGEPTPAPTPPPEGSLPVQISLVFDNYPEEVSLEFIRSSQVLHRHYEGAFSGMESFSETLHLLPGDYEMKLMDSFGDGMCCKYGNGSYEVTATFSDGNMISLAAGSGIFNDTLFIGLSVPDDPNEPKNEFTPPTDAPSPEVNEEDLSTGQNDLIEGGGNDMDRESPTADCVDNPSAPVCAFLTENLEKYSYLCQLFQVSYDCPSTCGACAYFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXE1</accession>
    <name>A0AAD2FXE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS15928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001894">
        <property type="protein sequence ID" value="CAJ1955797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1955797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="30069" checksum="7D4312D8B2BA02ED" modified="2024-05-29" version="1">MLDEFSVKFKVDDKQETPAGNNLLEVGKGKLLDKDQQTEFHRFVAKHLFLTKRARLDMHPTVAILASRVQNPNQSDWHKLVRLMRYMHSTKKWHLTLSADNLRVMKWYVDASFAVHPDFKSHTGGVMTMGGGAMQAMSKKQKLNSRSSTHAELIGVDDAITQVLWTRMFMEEQGYPIEKNILYQDNMSSILLEKNGRLSAGKRSRALNIRYFFVTDQVEKGNLTIEHMPTDDMWGDYMTKPLQGEKFRKFRALIQGEQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYD5</accession>
    <name>A0AAD2FYD5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001930">
        <property type="protein sequence ID" value="CAJ1956993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYD5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="172" mass="18587" checksum="5FCE6E30BBBE1EB5" modified="2024-05-29" version="1">MAESEATASIGEGILTQVFSSCSADPRGSVHRLWGISLLFVVLYFVVAIFEMMNMKSNDGSFAVLIASIWSGLVHLGLGVLGTFVLKRFPTSFSVGFLLGVMIVIANQNLLLFATFLKFGQGDKTTNTLFAVVGLCVFGVMSFMSLLLFHFKQDVVVAQLESSGKESNRDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYT7</accession>
    <name>A0AAD2FYT7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS16454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001925">
        <property type="protein sequence ID" value="CAJ1956905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYT7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="248"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1956905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="513" mass="57683" checksum="2ABADD7C0E521217" modified="2024-05-29" version="1">MGSKSSRRKRRNQEAPKEPKFEEIANPSDLASKALVLIHSMPQHGCTNECSCKNKSSGKPLKNMFRRKQKQDTIISNMSIGTIGTDASTSQDEDDDMNNNKNEPQVVGPSATKEKVKQIKNIAREQCSMASKKTIYKLTDLMKSTKNKKSILYANRPMLTTDSHNGGVEISLPSRSSNESSNSTTSRFQNLRTYKRAAGKRYAKVAQKLSSSMRKSSDHDGVVEEDDHELSPLDDDGMMMMRMMIQECAICDGTMSENDWNHPLQCKTPQCNYNFCASCIYNLIESSKEPYGVASDGSQQVKVQLHCPNCRDDLTCSLRRTLLLRVADSKTVPAPERSQMMLDLSGLPQIAQPLTDKQKVMQLDDIDMEVCRARAQERDFLKSKPLASNSLGHRRHTTQQQQPSKRQATSRSKREAPDAPAQNKAAATTNHAASRAARERFETIREEYDAATTRGRFPQDDDDLRIYNDLVADAGHLVYEKRESSFTVNQTACFYIDTQVNLGGMNPRLRFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZE9</accession>
    <name>A0AAD2FZE9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001945">
        <property type="protein sequence ID" value="CAJ1957436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZE9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1957436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="159" mass="18214" checksum="B2694DDFC0BFFE74" modified="2024-05-29" version="1">MKVKSIMDEDPSSDVSHLFPLKVETPNDRSVEVKKMEAEVKRLWKEVGDLIEEYVLISVELLTKCQDPEAYNKATIEKDSHEEFLMESVSEALVACIRMGQYAGYQNGQQKAKNSQGLADNKWIYSFVQEGSDKWMQVLSPKKRDCPAMCSISKRQKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZK3</accession>
    <name>A0AAD2FZK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001977">
        <property type="protein sequence ID" value="CAJ1958403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZK3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="373" mass="40194" checksum="7112D3ABDB179EF9" modified="2024-05-29" version="1">MANVDAQVAAMTAALPQVGAQFLAQLQAQQTAAAAAAAAPAPPAHTAVYNLHDSGQPVDLSSRSGAAAADKASAKLPIEITGKETEIVLWIQALKSHCSETYMEAAGPTGILDFGGKNLLTHYHSILMTDILQLFGLNGSMPTLGKGDRPTLFKAIIDTTAPASLLVSMQALTDLGILDPADFDFDIKRINAKASQLIALATTSARSLSDPECIQLLLTIYSRIKQPHAWFLWVQQKITDFEEGQMNAPAGGASLYPAFMQNAARKANQLNVDKSQSHAWKSTTLTEDVVAMTADAKKYFDAKNNKKEDNKPPAKKPGRNPTAPSSKLLPPFIKHFKKPESEGNAPYIVGDTKDFKGTTWHFCNCPTHRDKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0J2</accession>
    <name>A0AAD2G0J2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0J2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042255315" evidence="1">
        <location>
            <begin position="20"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="373" mass="40386" checksum="9BA0A43E25D6DE2D" modified="2024-05-29" version="1">MKLLSAPLCLLFTATDVSAQSLGSVSDSLKDSFSESISNIKNALWRSPNITSSIDGSHEIKVTVSPLVDSITIEYGYDASPLYASDNNNHRRLEALLSSNQVLLQEQEFQSRSTSSKINNRAHAGRNRRRLQQDYDPFFVFGGTVQGEYVHGSHYKANWNETFSVLVEPAANKKSELYVLMDEASKTTFPCIYFPYGNLTTADVIAMVSLDDAIASGGEVGHVSFNTSTGAFTLYSNETAVPNSAGGQFVPDVYVSGSIPGSNTSLSNLFGGIDGTVFDWTPTSKFTVTTLSAKDYLINRGVEKLTIDVYAENENLGLFAFALFDVDTQGNVELADLGLEGGNQRSQRPSSAVELVTGTSVFLAMTTSLLSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0X0</accession>
    <name>A0AAD2G0X0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001917">
        <property type="protein sequence ID" value="CAJ1956587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0X0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="493" mass="55510" checksum="93877D979AEC9595" modified="2024-05-29" version="1">MEARSAMHILNAPSTKSLKYAIQSGLIKNCPITEEAINHAEAIFGPDASTLKGKSTRPTPKKTHNDFLSPPEELYQHNRSITNLKTDPVFETLDKIFRHCNKAGFQVKMIKCDQAFIPLTDDMLDNIGVTIDPTAAGDHEPTAEQNNRTLKERVRVALAHRKRKTKNEKHRTDRNFANGICSLSTKVYVEIAEVFINSLAFHCFTMGKYTSLKVVSTTANKAGGSTSKSVSVAKKSEEKRLENASAVDLCQPKDRDPSGNNISEIQELIAFFSPLIDFGLSTHDLVAIGYNYNSTKILFGNSIFNQWMETHNNWLTQALPRFDSPFKDPYANYSVEVRVNMLFAQYANDWRQALKFLISLFDDDAMGNVDKNMEYTWGVIEGFPNNETNKVEIHKGVKKIFDPDYKDLEEEDNPVGAKDTGLVNKFGQPDGWDSDETVDDNSNNRRHDMEIDGNFDSGDNRIHNDDDAKDEVEEDDEDTDKSTKNSVILVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G194</accession>
    <name>A0AAD2G194_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002006">
        <property type="protein sequence ID" value="CAJ1959591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G194"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="162"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="413" mass="46971" checksum="493712CA7457287D" modified="2024-05-29" version="1">MVISLDRNAQRQVDQFQGWAANCGVEADNGFCLVGGMVDGNEDYHAVTSTGASQGNRVLAVPSEMILSASQIAQEFRGYVESALQSLEQKGYLHLEPHFHLFLKILMEYEKGESSAYYPWLNSLPRRWNTAVSFDYFCMSTLPPYIKKICQKKRDELSAFQESLKYFDYILPETKSDDELVKFAYNVVMTRILPSQEDHNIVPAADYFNHGNEANIVICYNNNNNNEQTTANCEVYASRDIAPGEALTLTYDMPTNPSHLLATYGFLNEAPATYCKLLFTNPSEKLKQIGYDPSQLLFSTQDGSISSPIWDVILYSKLERTPGMAEAKNAFYEAHMSGDEATKFAIHSQFQEATCTVLLEHVETILKEVSQLTCMMEQFRDEDRHPRLPLLMEHHAMVTSTFSKVRYNLRSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G491</accession>
    <name>A0AAD2G491_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS19624</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040002103">
        <property type="protein sequence ID" value="CAJ1962312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G491"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="14">
        <location>
            <begin position="299"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1962312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="546" mass="62092" checksum="ED8B875FC89D9763" modified="2024-05-29" version="1">MVRKGLFGYLGLCCLVGLYFFGNSRKLNGYGASKRETSHDISASDSKLESTLHDNSSQHKVNIRVLYNVSEYTNASSSLSSSASSANAAYPNLFDGKEYTTTLNPADHTNTSSMASYLANNQSLLENREDFTETNSSEYTTTTASSSSSSSSPSPPHHASTRSIQSNNSANNIYYLNGTYAVVNPWYGWQPEPHAMDCSWEECKVNDHTCKYCRDSWEEFYADVPNISSIDPGKDWIPDVTMLRRMYLDGYDANGNPWPPPLDDELCQLMGNTSSKELLDVVPITAPPMPRRSEPEGNRVLCMIYTMEKKHHTAIRVMRETWAPGCDGFLAFSTKSDPRIPAISVNHMGREKYGNMWQKVISMNMFVGQHYISQFDWFYIGGDDLVAFPQNLKNYLARFNSSEAHYIGRRFKFDEVGFNTGGAGYALSRPSLQCLVDHRIDSRCMPWKASAQEDVLTGRCLKHACNITYTDTRDEQLRERFHHFGPQLLYIYKGKIPWYRKYNKEWGVLSGKDCCSPETINFHYIKNPATVRFLHHYVHNCNRTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4K2</accession>
    <name>A0AAD2G4K2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS19814</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4K2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042130793" description="ATP-dependent RNA helicase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="188"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="453"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1962703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="625" mass="67432" checksum="7AD906A6839D5DCD" modified="2024-05-29" version="1">MILHSLLVCCLILPDARAFSLSALPRTVTSRTSTTSLASSDSAKAALERTASHLERLKSREDIVSSGNANTDHAFEALTREYLQRPANALKGELKKLRQPTKGGKPDLARRLAAYDIAKKTGVSPVGNDNSEVKDWNPAEERKKGDTVVGEALGPIDTFCGLKLSKAASEALGKANFRAPSPIQEAAIPAQVNGESIIVHAETGSGKTLAYLLPITEQLWKDHYAEDDDGYGFIMTPTRELAAQVAGIASVLAPPGTVRMVSHPTNLMTDGLKDRGERENGGRIDDGDGRTMPRLFIGSAKSIMGSLYGDGKMPAPPTTKPEAKYLLANTRWVVMDEVDRLLDTKRGRDPSTTRNKHEKPAAIVTSAVARLTFGRAQVVSVSATVGRTLKRELSRVLGLPPKEFPAVVRGNDSMQEEEFRKANTGGHLGRAVTIPETVKNYIVPVDSSSTGKVLTSAFFVLRELNKQQTRRILLVLTKGSGISTQNTLGALKHFQCKPEPRSLLDVLEADGTDRLIEVHREVSGATGVGEAKGVEKDQGYVLVTGEDSVRGLHLDGLDAVVVVGRAQGPDEYTHIAGRTGRAGRRGSVFNVVSGKEASAVKAWEKMLETEFLEIAIEDIPNQNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G519</accession>
    <name>A0AAD2G519_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS19910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G519"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48252">
        <property type="entry name" value="HISTONE DEACETYLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48252:SF77">
        <property type="entry name" value="HISTONE DEACETYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1962903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="405" mass="45624" checksum="CE1D400324337CB3" modified="2024-05-29" version="1">MLSVHNHDDDDDNDNDTISDRQSNLDQQVNKLLIDQAAQLIEAADILLIATGAGFSADSGLPTYSDVAQNPIYQALGIDYGDLCRIQCLKENPKLFYGFWGTCFNMYQRQVQPHSGYQLLKTWCDEKQVRLDQRRKRQQQQQQQQEQHTNGDSIDKPKSAYYLYTSNVDGHFRLAGFSNEWLHEVHGAIDTWVPAIILDDNDSNDYDDASENKQQYPVPDSYSFPIDAETLLGPSPEALRESIIPPKDNNDDMSMSSCRLRPRVLMFDDGFPSHTQMGLDTSCERYQAWESTMESAMEASHCNTTSSDDDNGMKLVILEIGCGIRVPSVRIECQDVLCDTAGRCYQRSSSTSADDSRPSCSLIRINPDHESIEHVPPNATGVSIRGKALETLQAIQERINILKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5E0</accession>
    <name>A0AAD2G5E0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002121">
        <property type="protein sequence ID" value="CAJ1962800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5E0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="271" mass="31081" checksum="CC4A92B2347884FF" modified="2024-05-29" version="1">MVKKKCRRNCFWEKGSLKVLDPDHETNSIAVFGKPNGNQGLTDFLFYKASDRQRGELKEQWKDVRNLMPKAMKQKPDVARGKQSAALYQRCICFGYRKDPKGSDIGEYAYQKHGKKDNESGDRGISDKFWQLSESLEGISNRFGKHLFEAKWMDDLRQRVLLPSFAGGKAKATQFSVGIRYWSVAHTDDDYYFTTLSCLSKNEADHDKVLYYFIFPSYKVAVPMKLGDIIFFNPLELHCCSNPSLPDAMIFSLYVSAKTFNARFASYAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5Y9</accession>
    <name>A0AAD2G5Y9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS18857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5Y9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="531"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="773"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1157"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1960714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1193" mass="134890" checksum="4B63F8C0576CD1DC" modified="2024-05-29" version="1">MEKISETESSGKSSSNVGKQVILPEREDSTLDDSIHFNTNEQEVVVQDDGIEKAAISCLRFFVLFLMIGSTIGAGVATWKFLSSQEQEDFNKEFDVIAEDIKQLSYRRMTEKADDFASLASTLTGLAINSNTIWPFFTDSNLPMIVSNFMATTGAGLVFLAPLVQGEQEREKWANYSQQNQGWIADGVEFTKQQGLLNVSDIYPTIFRRSNGENVAEEGSGPFLPLWQFFPSRDSPLVNFNMLSDPHYKEVFNSVVESKELAMTDYLGITNQDLVELSGPDTQYLVSVQPTSLFLTPVFKDSTNQEVVAILNSDVSWLPMFARASDEDIPPVDVVIDEGCQRRITIRITAQKAEFIGFVDSHDSTYDDYEVAFPFAPDVPSHHLAGPDCSYTIRVFPTKEFWEIYHTSNPGTTAGIVTAAFFFIGIIFYLYDAAVHFRQKRILRVASQSEQILSVLYPKSIRDRLFGIEEKKEEEHKSVPTTKRKQMKEDLIKASRYQLKHFMKSSSPSGQGDSLEGFGSKPIADLFLNATVIFADIAGFTAWSSVREPAQVFTLLETVYRAFDTIAKRKKVFKVETVGDCYVAVTGLPEPTKAHASIMAGFARDCVSRFVDLVSVLETTLGPDTGDLGIRVGMHSGPVTAGVLRGDKSRFQLFGDTVNTAARIESTGMRNRIQMSEETADLLAAAGKVHWLRRRDEVVTAKGKGKLQTYWLLTKEEERAEMEAAADKLSSENDNRAVIQEQINQAPLDIKTCTLEEVESLLSPKVRRLCKWNVDVLAKLLRQIIAHRNSSDAVHSSNEDVLSERESEIRDQYMVLDEVVEIIPLPGFDPRVYREQQNPEEVHLPDAVIDQMRLYVACMATMYRDNAFHNFEHASHVMMSVSKLLSRIVSADDVFNADENAAMSRNLQWSIHDHTYGITSDPMTQFSVILAALVHDLDHLGVSNAQLVKENHKLAKVFKSQSVAEQNSIVLAWDILMDERFHDFRRMIYTAPFELERFRQLMANTVLATDIFDKQLNTLRRKRWDLAFHGSASALQQAEDTTRDNVNRKATIVIEHLIQASDVSHTMQHWHIYCKWNERLFQEMTAAHKAGRLAFDPAEKWYEGEMGFFDNYVIPLAKKLKECGVFGVASDEYLNYAMENRREWEEKGQEFVADLVRKHGQKKSTSSRLSKSPKRNSRRMSLTVGYMSKVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7T0</accession>
    <name>A0AAD2G7T0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS21382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7T0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042269615" description="DUF1275 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1965790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34439" checksum="7A816317223D7D79" modified="2024-05-29" version="1">MKISNFNVSALLLAAMAVTPASGFVTSTTKNNNPSSSRHILAYSRQQQMSRPITHLPTMDLSPRSNNLVKLQAASINDSVNDIKNEITSSFSRLEGKRRLGFGMAFLTGVSDLALNLKYKCFATMMTGNTMWMALAMVEQRFTDVGFYASVILSYLAGLAVFRQSDVALKKRNTLPLSAFFTAALFVGSDVMFSMYGSRWIPTMMLAMGFGIVNSVGQDCTGTLTFVVTGSLTRMMAQIVDRVSKSAGQKKLTVQDKQGFLLNASIFGGFFCGAAFAGVLKAKGILVQKLGVFSGIGLSYALLFLWKDNIFQWKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7T1</accession>
    <name>A0AAD2G7T1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS21483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the parvalbumin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002236">
        <property type="protein sequence ID" value="CAJ1965895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7T1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008080">
        <property type="entry name" value="Parvalbumin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11653:SF10">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11653">
        <property type="entry name" value="PARVALBUMIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR608080-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1965895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="295" mass="33843" checksum="87DEC80B6F66B08A" modified="2024-05-29" version="1">MTDVVESKIEAVMNQKRKSELITANEENNADKQDSIQDETDGTKKVKKAKQSISIKSSAIEICEAFFKCMDFNGNGFIEEGESKILSVVAFDKDLESADAHWTAMVTAMDRDSDGKISKDEYVAWWTERHANKSVKEDGTFVEDYARYLLECLQRISSVKVAQRMCDTFFEAIDYDNNGYLEEAEVKNVSRWAFGKSAEEADATWQDMLEKMDSNKDRKISQAEYRTYWLANAKTKIQPDGTFVEGYKRYLLKKLMKIKNGNARQEQIRKWEKEHPKSGSNVAQGKRSSVSFKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7W5</accession>
    <name>A0AAD2G7W5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS19952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1962983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7W5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000060">
        <property type="entry name" value="Sensor protein FixL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF3">
        <property type="entry name" value="HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="126"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="278"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="548"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="726"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="883"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="12">
        <location>
            <begin position="1038"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="859"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="779"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="938"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1962983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1136" mass="124585" checksum="5021482E293151F1" modified="2024-05-29" version="1">MDAELSTAILAAVIDPTIVIGEDGIIVYFNPAACQAFQMDADSVVENKLNVSSLMANESEAHQHDQFMLNYKETGMKKMIGRNRRVLAKRSDNTTFYASLSISEVTLGGDIFFVGTLRDVTETMEREELFRNVIDEAVDAIFTINEKGIITLVNKSAQKMFHYKEHELIGNNISMLMPQPHRAMHDQYLEAHFKTGIQKMIGTDRTVTAQRKDGTEFKCRLGLSKIETAGTSGASEQGGTTFVGLLHDLTLELAVREADARAELADRMRKQKALFLASMSHEIRTPLNGIFGMLELLQSTQLDSVQTEWLATCSRSAQSLTTILDDILLFSRADGGGISLERLSFNIRDTIEDAVTVMAPKTNDNAIDLVYTVARSVPDFVIGDPTRLRQIFLILLSNALKFTQVGHVALEVSVEGVEDDSDDDSETDDEDFLDKSKKTVDDNKVVLKFEVSDTGIGISKKHIKKLFQPFTQADDSTTRQYGGTGLGLSIAQKLVSLMDGDIKVESRPGRGSTFSFTSVLEKDPDGSSSSDLHDNVSEEDLKLLKNVHILSIDDNAVNTAYLVNLLKIIGCDVKGARSGTNGIELLKLAALREDPYEIVLLDFAMPHMSGLEVAEFIASSQSIANTNVRIIMLGSIDVHRSIAACPHVHGFTTKPIRRFPLIKMIVEQLKIKRGMLSLTNTARLDLAKEDGHNDESEDEIPGPVQSLERRASVGFSNNGQRPNPLSILLVEDNLINQKVIVSILTRWKCQVTTALNGLSGFEERISHRGKRAFDLCLMDLHMPLCDGSQCVKMIREWEEENNQDALKIVAVTADADKDTEEACLSGGFDEFLPKPLRKNALRDMVVKVCGEDRLSTEVQKPLRSAASGGPTPRSPSPPAGASHVLVVDDAPTMRLLLRTFLVGMGCIVSEASSGESAVELVRTSLADKSERIEMVICDMRMPPGINGIETARRIKEIPGTEDLPIIGMTADDVDRGAAERAQGVGMVSLVSKPVGRAAIARFLADYTGTVGSSPREKNENESPETFDKERALDNCSGDKALLKTLLGDIGRDLKVRADELRTSVSRKDSARAAEIAHNIKGLAGMCGFDRLMKAAKQLQESASQSDYLEVRNKSQVVMDEIQATVKIAEEYDPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G8D8</accession>
    <name>A0AAD2G8D8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002263">
        <property type="protein sequence ID" value="CAJ1966197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G8D8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="276" mass="31232" checksum="A9B10715D835D4B2" modified="2024-05-29" version="1">MVYDGTKWGLNDSLWVPGFPLPTVDTMLRAVTYDTVMSDFDIGDCFLNFVLQETLQSLCRVDLTKYFGEGDILWERWVQAAMGLKSSPYQAVQAIMVAKEIALGDRKDPKNSFRWDEVKLNLLGSSTYDPSLPWVFKIRWSDGKIAADLFIYVDNGRVTASNKLECKRATRQAASRLNGLGIQEAARKRRWGSQNPGAWAGPLVKTTEDSVSVFVSQEKWDKTKLQVKQIVEELSGSTLGSLKHKPLERKRGFLIYVTRTYPTMRAPQFGEYAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAF5</accession>
    <name>A0AAD2GAF5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS22325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002313">
        <property type="protein sequence ID" value="CAJ1966742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAF5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1966742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="680" mass="75186" checksum="61B54D8EFB77DCF8" modified="2024-05-29" version="1">MEDKSMKLRPMKRQRVEQSSSSSSSRSSSDPAEVNTTTTSVSLTDLLRAGKWNEATKRVEENPNEVTAASDPSPLALACRFGASVECIRRILEVCPQKVRRLLDSRGTPVHEAIVCENVGPDVIGLLLKADEELGADSPRATVMQDVDGYTPIHLLIRRRFQSHVLGSGEHFMELLEMLVQSAPESVVIPDRGEYEEPPCVMCLKANVYAPLLQLEGATAVRIERDIHDMVRCMLQHYPSAASCVFSGYRGKYTALHSAVFHGRCPDTIRLLIEAEKRCPTSSEEKPGLLANTQGELPLHFCSMRGEPPRTVALLAAGAPEAVSKRDASGLTPMHWLWIRFVSTLLAIDDAERGNLACIPIKKSCNMKTTESNKYSSFAFLEQGDFEADLQFVRRVDPSVDFLRMRHIPGEVLDETDALNFAKRTETILQHVRDRHRQLGAANLDENDDNDGEVLWSRVETVASLFWTKVVSMLKAVETTSDDQDGFSLVQAAFKSQYCPPQVGRIVASMYPSEMADKDENGMLVLHHAALRPWHAWDWPRNTTSDSANAQLLELESASLLRTAMELSPLSAGSQKDVTGRLPIHCAIPTFVRAFSSSGRLCTESSVKEILELLTMFVKMNPDSLHQTDPNTGLYPFLQATAVSTEEASASAGSFPEEFSLSAVYTLLHADPSIVRSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GB83</accession>
    <name>A0AAD2GB83_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GB83"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="361" mass="38383" checksum="964FEACBAF6A78EC" modified="2024-05-29" version="1">MSDNEETKNEPVIHLKVPTEIHRDTIKRRGMFAKRDKTEASSRRLLIADSVDDVLYPPPAPVRMAQNYTPIAKEVKTVDSAKIDESGRSVVSELTLDASARTRGVDASARTIDSSNRTEPSSNVVRQRKAPKAKSPKQKTKKTVKPKKSASGDDEDDDDDDSVSVLSDELSTISEKRSKKNGSSRSLSSTSSKKSATKKKKKTSKANRRASMKSMGSCESIDELTVTSGEMSFDGLSLADSITADSGSADAPVSSRSAATTDSSRRSHKSKKSSSATSRRSSTGEISKSSKKSKGSKKSSKGSVPMVIGSGCGGDTDEVSEVGEKPPSLMNSTLSDGGADTNAQESAVLSQGLQALGQFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBA3</accession>
    <name>A0AAD2GBA3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBA3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1967326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="666" mass="73897" checksum="9F196FFF7D7BF3AC" modified="2024-05-29" version="1">MQTTNQGNDDGQVDFIPSPTFQGAKPGFYFGTSGNGTGYYLDRLDQAREVVAGKKRKRAVRIAEEQNETKLIPNLLEQAEKDAAGSTVLELTPKGIQSATKALSKIAQQNAMQRAQFANEPRQYMNSELALYEQLTALQAVAANIHLYQHLIDNQALIETLTELLGHDNSDVSAATVGLFLEWIDPSLLSSTDVSMVTIFPVMKALASQVLHEAWEAIAANLSKSRQSEEEEDDPNNASADNDDKESSLDGVQNSLSLMENLLELDLMFPKGLLGTEEEENDDDDDDKDKEATSSLSAAAYMVKHSNILSWLFHHLDTKESSIELKARCVEILSLLSQKEDIFTIHPDWTQIPLLTEAEGESQSSSKSAASTKKTINGIEVLLQTIGKHRKKQPESDQQVEILENTCALLSSCISFSTLNLEGFLEGQGIELVLRCLKERVHAGGSSLKLLDFFGTLPIHKKACESLIKAGGLKYLFPLLLGTRIPNPTDAKVGTTTLSVKAKKEWYQSIQTQVIRILYSISRYIDDDSPEDAKVRFVSKFAADERKCDRLVELLLHYDQKMRTAEYNFYLHSPDDEEEEEDQEFVQLAAMDAKLQGGGELFHRLGATTAFVCLHSKKCHARILEQLQLQRSGMGLILSALNEFASVLGEGTQKDQIQSLKAKLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBA8</accession>
    <name>A0AAD2GBA8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS22778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBA8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1967444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31932" checksum="529879A49593C8EF" modified="2024-05-29" version="1">MTNTTSSHYEAHSNESYEEAYFYEPGTYMQHLVDLVGTRLKLGDASPPCRLIDIGGGTGNFAQALMDSHPSKFVSTVVDPFLDPTASGKDVKGLDFVKESAEVFMQQNNSEDVQADDSYWRNGYHKVLLKEVAHHFKAADRVKIFKGIYNALESSEAAGDSSDDSALLIVTRPQVEIDYPLWDEARQVWKENQPSATDFMNELKEAGFVNIQQTLEPYPCQIPLDRWQSMVKGKFWSTFSNFSDEELEAACETIAKDYADRVGKDGILHFEDRLVFISAGKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBD7</accession>
    <name>A0AAD2GBD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS23135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002369">
        <property type="protein sequence ID" value="CAJ1968215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBD7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042244071" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="669"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1968215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="706" mass="78776" checksum="F87E48ACAFFADFB3" modified="2024-05-29" version="1">MNRFFAFGIVAILYLPSFDFTATSCGLKEARRLLNRLEDDGWSDVLQSCSEVQYETSIYVHKHIFVVSTPVVKGDSGCPSIAMEQSGALGKPSDADSDALTDSEIRTVNVHEVILPNYIDPKSFPYLPLGTFLLKEIAKAFHNAKAQVLSDPDSMQNFDIVTENCGHFPNRMMDLLNVEIDHEMVRFIASRLQKTNPALAQDVRKSPSATKLLSDRSRLDDLTDLQLIELNVEFKVKHLYNSSTAPLSDIYNNKLPKEEGRRRRILSTEEEETVTLKTDRRLSETKCGRWYSSRCLAESDIRYDPTASNAIADQNPLWKKLEGLYEASATAYGPDGRAIEPSFLKENAVSFSPDQMPYTQAPYKMFINITLSGSRMYEQMHAIYPPPPSAFCTQPIPEGMLNVILPGQCGLSGTSGFYERFGTSTFEKDGSLAMLPFGSTMTGVKLDRKSYVSLPAGESNHFSSYMEGDLLVQYASACLDAECSQLSTTIDYYVTSIPEGEEFKVVASTRMLAKRITSSEDFHDALEQAYFENNVPPDQRPFKGDCLSGYCPDKSDWCEYDPECAVSPYQEPEASILIGPIAGIGLAVFVVIFSALFYFHRSQMKQKEAVLRAKFAGRIAEGIRVNGNAGSLSPDELASEFHKIDQDKGGALEKEELWAFLQSGRVGHMSRADFDMLFSVIDIDRSGNVDFNEFVAFFAKCDMNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCH1</accession>
    <name>A0AAD2GCH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="2">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS23779</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000016">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="13">
        <location>
            <begin position="46"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="12">
        <location>
            <begin position="368"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="736"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1969572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1024" mass="114524" checksum="33CDCAC69EBFADF3" modified="2024-05-29" version="1">MPIRTNVMGMPPTTSGPAGMSDEKSNWVNVAWMPHSCLSQTSHLCLSVRSVLTLMEQHCEIEEWQVRVTVHGAAGLSLVPVATTTSTAPRLLIKDFWQSHENGMFDKDAEWLPLVSSASHICKFDSVIHIPIRWRDLPRDAYLLFEVLGYCDKVLYQSIMPMFDAYGKMQSGLTKLDLTPPSHGMDRFNEGLLPPPQKGDNTEWQIDDPVWKASKILDQLERMEKSKADATTNRGGFKTFGEIQSVPWLDKMTKDYCEQTLSEARAENEYRPVYDTDTVSAHLIVELPTYDVPVMHEETFYPVAQHGPSGTVTPLDLALYQQRKVPAGKPSQFHPLRAVPFLDYENENDNPVEDKYRALAHDLLRGLVDPALKPDRVQRDQLAAIIASPSHQPTREEKDLLWRFRFSLVDNRRALAKFLLAVEWTVESEVVQAAELLEQWRKRSPIMVTDALKLLGKQVAYQTNLVRAYAIDTLAAAPDEELSLYLLQLVQALKFENIQETGSNTMTQESEASLANFLILRAAKNIQLATYLYWYLKVELQDPTHGARYTEVFSQLELVLAQTPFTRSKKREQKSLLDASTPMKKVEKAAEEMVAVPFKNIVDSVSKKVDKVSKKIGSSLKLTDLESQAIDGSLNKKGAKSVWDVLKAQDVFISGVMDAQLSCGSKGKKDAKEAHIRSVLSKEGYDKNHTRDSFPLPCAPEVQVHGLNSQTAKIFKSAVYPALIEFHIESIAAKGDFGMESSQKDTSRSKYAGQNPLAHQSIYKVIVKTGDDLRQDQLAMMMIKLMDGLLKRASLDLCLTPYSIIATSPTSGLVEFVGGSMPVSAVLANHNNSVMQYFQAVAPQKGAKYDIRPDVLSSYIRSCAGYCVLTYILGVGDRHLDNILICKTGHFFHIDFGFMFGRDPKPLPPAFRLTREMVEGMGGLESTEYRQFCSLACQAFNALRKNAGLVLNLLSLMSDAGIEDLSNNPSADPEGVIAKVEERFRLDLTDEQAERFFLNLIGETLAAIAPRVMDVFHSIAVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCP4</accession>
    <name>A0AAD2GCP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002325">
        <property type="protein sequence ID" value="CAJ1967440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCP4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1967440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="74145" checksum="1EEE380F96D17842" modified="2024-05-29" version="1">MGQSQSCMKQDAVQEVVNRAPDGSTGTGDSASNPTLNNSNLPRLDNPHLAKEPVITQVHRRHKGARLPKQRELMVAGLQVRQQQGESIAYLLNSLPYGSIIQVESNTHLLIAQPVRRLQLAIYQNHLGNVQIATVTSQEGIVPPRFAQGQILVTVNGKSIKTVDQAVEALSVPEKLLVVMAEAPLDKKDRQQMKGTSRVVDSVLTKQDIRRSNSSLLDSSSHRPEEEKSREDRHRHHRRRRKHERRGSGSSHGSHGSNRSRGSHGSSKSRSSSRRSSSKPSSTTPLRNKDKVIPTISDQQQRQHIRRNSSNSSMSSSTNVESRGGGDNKIWVAKDSNGSNSTHPSTVDSNGNGNGNGDYDDNKKKASSSSSSRIVLNSTMDTSNTTVVSYDDSQLNDSFLVLSPTSSVASPTNDQAVHVVTPNKSVQNISKIASYDEEEHGHPLVFQTTSSESEHDDGHAGAGAAAKPADATGEDEDGSKLLSILARLDKFLDETMMELAFVMIEMEDLQHKHNKPIGDVPAGDAAASPTASPTASTVSYPSMTAEQLEALEKDLRLKMFDILEARQRALDVDHKKFNSKPVAQPPLALPTIEEQPKLTAASYLDQQVKEPPSPPPKLSLPPSASTKKLVVLEQQLLEMQNANKALKQELAHKDVQLNEFQELDKQVQQNKEVSTRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD95</accession>
    <name>A0AAD2GD95_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002502">
        <property type="protein sequence ID" value="CAJ1970348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD95"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="171" mass="19138" checksum="B434DF7B68907144" modified="2024-05-29" version="1">MISNESQSPLAALTEEIGSSAFNYLIKTFSETILQNVDLEVAFKGMEAEVLADHMKNLIKMVFGYKCKSNLVNSNIRGQVVLRNYALFELGLSRVQLRKLQLHFEAAMRDSMVEGEVFEQCKERFTDLCIIFDAEKRGLQQQSSDAMSNDPAMIMMARAASSRCLVAPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDE4</accession>
    <name>A0AAD2GDE4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-glutamyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS24503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002524">
        <property type="protein sequence ID" value="CAJ1970487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDE4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051792">
        <property type="entry name" value="GGT_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43199">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43199:SF1">
        <property type="entry name" value="GLUTATHIONE HYDROLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042007030" description="Gamma-glutamyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1970487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="40923" checksum="877E7B5CFFD7A2D4" modified="2024-05-29" version="1">MKLSNLALLLSATATVYYAEAQSVETCKQGGSGMVSTADPAATEVGFKILEDGGTAVDAMVAVQAVLGLVEPQSSGLGGGSFAVYYDASTSSITTFDGRETAPMAATEDRFATFPPGLQGFVGAWQGGLSVGVPGTPLLLETMLEKYGSKSMSELFQPAIDLATNGFLKLRPATFFRDPMAFEYMMINETCQVKSPGTNLTNPEYAATLEKIATMGAKEGFYTGDMADAIAAAVQNDLGIPGDMVVADLESYTVIEREPVCVDIGTDSVCGMGPPSSGGLAVGQMMALLEQVQDKLVKSTMVDDTNASVLDPTNVHLFTQAGRLAFADRNKFVGDPDFTSVPSEGMLNKEYLADRALLINATSDMGTAMPGVPPGSAGMQMAMDSSVKNTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDW3</accession>
    <name>A0AAD2GDW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS24509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002524">
        <property type="protein sequence ID" value="CAJ1970493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDW3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042254965" description="Peptidase S1 domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="90"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1970493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="436" mass="48437" checksum="A379E8FA82DE86CD" modified="2024-05-29" version="1">MFQFCIQFALIGVLICGIAVEAAAAADEHQQANNLVNKRLRARIRRDTPPTADFQEIDFDFDGNEVLEVLVGEDEEMNLEIVDGEAVQQIVGGDESTLGEYPYFVDFGNCGGTLIAPDLILTAAHCEDYRGYLGLVGAYNRGNDSTEGATFVKVTEWAQHPYYDDYTLKFDVALMKIDPPVYLDSDIVLTLNDQDDLSEGESLTVMGLGVLEEDANDDGVDTLRDVTVEMIPNFVCNSEDWYDEELDYTMFCAGYQEGGRDSCQGDSGGPLVRKIGNRHVLVGIASWGGGCGYQQKPGVYSRVNLAMRWIKQVGCTEWDSPSSFCRGPRNRLGGVDKCAVNEKEVDFTLLTGETDGEVEWEIASFEAQRTILRETGDEKWETYQTRRCLPQNTYVLMIKNPRGQGLAGGGFSLTVDGRLVEELYDNDSFSLKVIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHL7</accession>
    <name>A0AAD2JHL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NAD(P)(+)--arginine ADP-ribosyltransferase</fullName>
            <ecNumber evidence="10">2.4.2.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mono(ADP-ribosyl)transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS12769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19149"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:15087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142554"/>
            <dbReference type="EC" id="2.4.2.31"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Arg-specific ADP-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.31" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHL7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106274">
        <property type="term" value="F:NAD+-protein-arginine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.176.10">
        <property type="entry name" value="Toxin ADP-ribosyltransferase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050999">
        <property type="entry name" value="ADP-ribosyltransferase_ARG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000768">
        <property type="entry name" value="ART"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10339">
        <property type="entry name" value="ADP-RIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10339:SF25">
        <property type="entry name" value="SECRETED EXOENZYME S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01129">
        <property type="entry name" value="ART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51996">
        <property type="entry name" value="TR_MART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1950812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="352" mass="39211" checksum="D9B488D52BFB2465" modified="2024-05-29" version="1">MKTFNVTLSNNKTKTTKTITVIDQMTLTNSNITIIDNILSFLPNSESSPIESFSNTVSISPRSSLRLALQAHQELGSGWKNHSRYSLRLALKSSDSSVSASASSAASVSLPPPSNSKSKSKSKPRSQSRKRAASKKATSCPRFVRTACAAVTAKFQKLLCCRRHKEFRKRFTKNQERRQKFKNYEFAKALETYTTNEYRKINEALRSGTVDSQEEGLQRTIKDAIMAFKIGLRWGELKVCNSKKTLFRGSGSLPFVPQVGATMSDEGFYSTSLHKSIAVDFLAKQKVDEARYLFVLTSHCNGVNVKQFSRCKKEEEVLFAPSTLFRIASVAPGHIEAGVEGTITRVELHEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHP6</accession>
    <name>A0AAD2JHP6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHP6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF289">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE VIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="453" mass="51006" checksum="E9EB933C719D4C7D" modified="2024-05-29" version="1">MMTAPVQDKEKVRKAGAAFASKEIDKMFAKSKIVDSSDTFPQFLKEEIKLGKVLGKGGFGTVYECLSFDAKTKSRKQGGGLTTMSAVRNSFSLGAKQVVDEEADQGQMESRKFIADHCIRKGGDARYALKILSPEVVNDPGELIQGSIDMAVETRVLSDIEHPNIIKMRACGSISPFEVDYFIVMDRLYDTLESRIAKWANLQSRISSGFGACLLDRKGLKKKKLLEDKLVSAFDLSAAILYLHKKNILYRDLKPENVGFDIRDDIKLFDFGLAKEVFAADKDADGLYKLTAMTGSPRYMAPEVALEKPYSFSCDAYSFAIMFHQIYSCRTPFELYGMKSLRTRVWGKEQKRPYIQPDWPVSIKNLLEKSWSANVHDRLTFQEIYNILREECVGARDGVEEGLEHSKRRSTFVFTGPSTKKTSSKGAKPIMEALQEFDYDDDEEEGDEERGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIH2</accession>
    <name>A0AAD2JIH2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIH2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="93" mass="10358" checksum="3E13F2BB88084A64" modified="2024-05-29" version="1">MSTVTEKNGLKTPGAFAKDQEQPISWDTEGIVIESMQSIGQTENIVTENAEASISDASEDADDEMSWLAKVFDPTVQKIEDWEQDWDTDSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIR2</accession>
    <name>A0AAD2JIR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL25 L25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS14957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="entry name" value="Ribosomal protein L25, beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_bL25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_uL5_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33284">
        <property type="entry name" value="RIBOSOMAL PROTEIN L25/GLN-TRNA SYNTHETASE, ANTI-CODON-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33284:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L25_GLN-TRNA SYNTHETASE, ANTI-CODON-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL25 L25" evidence="6">
        <location>
            <begin position="131"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1954365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="350" mass="38685" checksum="6F8325EC4F95BDAB" modified="2024-05-29" version="1">MSRIRSYSLISRLISVQRPITFQGGSRCSNRALSSAYKVEDVSQLVSGLTQEAVDADPKVAAFLEANFESSEDTASDGFIIPDEVLEQLGVADIDIPEKKGKGSEYGAPRVDKGLGNEAQQALNIRTLQSYIREEEGSNACRRLRYAKMIPGMLYGSDPNLGVLSNTPESKTMLKTPWPTLQRELDRFHRRFESRVYDLTVFEDESDTEGTVHRVVPRNVQRHPVQGSIYCANFVRYFPGRPLKIPIVFANTEESLALRRDGFIIPVSKHIECLVEEGAPIPEQIELDCTGVVLKDVLRMDRLIFPDGVTASKRVDSEKFVVGPVVGGRGGSQEDDEDDDAAGGDEESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJJ1</accession>
    <name>A0AAD2JJJ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adaptor protein ClpS core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJJ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ADAPTER PROTEIN CLPS1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473:SF17">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ADAPTER PROTEIN CLPS1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptor protein ClpS core" evidence="1">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="189" mass="21532" checksum="E1BD94B182057EC5" modified="2024-05-29" version="1">MHDAIQRKESAASNEHYTYEKHPYRVYTKEISIIHLSMSLSTSRFFAILILALFGFSQSFQIATQQRIQRHITTSSQRLSAAGPATLDPETIEKVDKEDAIEFEDKEDPGTWEVRLYNDPFNKREFVARCLSTICGKSDTESYQIMMQAHKNGMGVIGVYAFEVAELYYASLQDNGLMVEMVPVGDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKW9</accession>
    <name>A0AAD2JKW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKW9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF8">
        <property type="entry name" value="WSC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58252" checksum="3E3B13CBD83743B3" modified="2024-05-29" version="1">MNQESSSEDRRSNNKRRSSNRRVSTQRERNDDDEYDHHANHHRNHKSHATHHHNQDDGSSKKRSSRAKVRPPSPETARPPSRSYATAIVDDDSTISVDDEKWHKKTWVRIMMGVIVIVFTVMITFFVLRATGLGLNKSAAIANGDASNAPSAVESSAPSSAPTPVPFFTYAAPDEDSCDEKSFETGDTSFVDGENTREFDFTFDVTMSFADSSGLWLQEFESKVNSALIPILVGCIDDDDDDDEDDRRLQYQERASVDMDGQLRGLHKASSNGSRRLDSDEMKFRYVIADATVIGMTTADLVCPQVLDSVSTQQDPRQGLPEICFRVSVNVDLLLRGEERVFSLVQLITTILSELSDPEQSLDESAVPVPTCTSLLDCMELTSPFKKIAVVGVTNRDPTNSPSTSPSQVPTNRPSTMPTNIPSMPPSLFPTEMPSLKPSFSPTSRPSPGPTLAPSRMPSIEPSFTPTDAPSTPRPTFTPQPSSSFGPSMRPTQMPSCADFWEPQDTDNQVIDPNDPPDTNCESEDENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPB7</accession>
    <name>A0AAD2JPB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS23753</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="588"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1969524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1126" mass="128503" checksum="35F66BF1D6C380AC" modified="2024-05-29" version="1">MKNSRKRRRDKQHKALPSNHNDKALFSTIEALLPPEQEILLLDQFIAKYAPNLKVDECTLKRFPTLVLAPLNSIVVSPSLRKVECWEPLPGLVDDVVWCLVQRRDKWKRLSCDARKRKADESLSSSTRVKKRRKLSDQMAPDGHDQEIQIESGRNVLAQGYAAESVEDLASFSNRHNHLFQPMPVTITPLMRPGVACFQPNDKVSLCKSSITFQQLHGSLGDELLRTILLHTRLFLPLSELQSQQPADQARNDCKHQEENFLMVCGPPLSQWEGKAAIKATSADDRNRPSFKRPRWIQQWVPMDDNHHHPNGTLSRHSLYYSSFYIPKIGLPKSHVLQLQTQSSPTQNGATILLRRMVMSDSSKQGGKKTTQDKRRWIRVRHYGVDLCHQILLGHSKCDYARLLNRYCAIPDTATAISTKSNPAIPAGQDDLITLAHSHATNESVASFLVSVLKAVFPAKFWGSGGNFDSVVESVRHFVMLRRYEKLANKRLMHGIRITKMPWLVGNKRAGTSWTKADHQVVTSLALGVLRWIFRGFLIPLLRACFHVTESEFAGKQLLYYRKPVWSIFRSLSMKKLLRKQFFQLSIARTRQLLVQQRMGFSQLRLLPKATGVRPISQLSRSPVFPFSMNCKPVMRGDLGRRSLPGSQEEYFSDLQKGSMKLLATNKILSEAFHILKYECSQLARPFGFGLASLSDFYPLYRNFILGLKKPRKNLMLRFASVDIEKCFDSINQDHLLKLLNELISRDRYFIQQFNQFCLNKNEGKLETKVRKIVDPNHQDCQSISKSLKNVIFDSRNRNVMSRIRVMELLTEHLCSNLVAANGRYGKRALLQSGGIPQGSTLSTLLCNLYYGSVEDSLFQGMQNSASLITRQVDDFLCISTESDFIHEFVDRMDKGNEALGVKVNKGKTLVSHLAEARMTHSIFGDSLFPWCGMLFDTMTGEVSMDYTRFHGGIARDSLTVRREGNEGSGLRSKVKSFILPRCIPILFDSAINSFEKVVANFYQTMLYGAIKMAEYLRSSQLMQSSNPEFLLKLIDDAADYALSEIKTNLKRQQQSGRSCNFALKKKTVCWITWRGFHDIFSLLQEFHEFSTLINAQLAYKTPCPRLDIILEKAYERFDVSNMISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPI2</accession>
    <name>A0AAD2JPI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002436">
        <property type="protein sequence ID" value="CAJ1969892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042074762" evidence="2">
        <location>
            <begin position="17"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="310" mass="34517" checksum="76AEC52F6D38A700" modified="2024-05-29" version="1">MFHHNILILCVTPTSGLSPTQMQGVRPILTNLMPIIGSIWLNPDEWLTPTERAVRLQRRTLINNRCRARLHQQAIQHRHQAPLPGGNNGGHAPPVPVQPPIPLLPVNQPPIPHVQPVHNQPQEAPNVQDNRNEVANDPSEAIEAGDHDNVDDDLSVPEGVAEDENIQQEEQPNVPTEVPILKQATEDVKQEEDETLNQTLQNLQEQAIRIGQYLKSSVNEGLILRPTDSFDIECHVDADFAGLYSVEDVMDPTCVKSRTGYVISVCGCPVVWVSRLQTDIATATMEAEYNALSMAMRDILPLQRVFKTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU25</accession>
    <name>A0AAD2PU25_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CYCCA115_LOCUS11273</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU25"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042112619" description="glucan endo-1,3-beta-D-glucosidase" evidence="16">
        <location>
            <begin position="36"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="786"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="414"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="541"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="753"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ1947717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="853" mass="92333" checksum="1644410C09F15A80" modified="2024-05-29" version="1">MMRNQYSSRSYGSIISWLLFSTLQPLLLYSNRVSAAPIELHGINYNTRQGPDFAWDKCKSMEQIRTDLNMLSRVTSRIRILSLADCGQGDMVLTAAKELGLQVWLGVWISEFEYVFEGEKGALFNLINNGLVDENTVLGVTVGSEAVYREEVTAETIIDYMNQIRGILADGGLSGLPVTITEIAPTYSQYSNLRSAVDVIYANIFPFWEGININGAIADMVTDLDWVMNLPESAGKELIIGETGWPESGSVSAEDIVGNIGIPSVANQVQFFRDFYCEIGVTRGWKYYWFTAIDNKWRQAQDIDNTIEGTFGFLDENLQLKSHFQDLSFTCNDGVTYNFAETDWTVPNAPNAPVDTPTETLAPNETPREAQENMACSVHAKCAELGLLGSCCPTNGLNPTFLSCCDNDNLFATPTTSPSKATPSPTRLTPSPTVTPPTPAGQTPSPTRVTPSPTRITPSPTRQTPGPSPATPEPTRQTPSPTLATPGPTRQTPIPTLATPEPTKFPTLAPITPAPSIAPVTREPSTSPVTLDPTVTPLFPSTGTPSAAPITQDPTSAPVTSEPTAAPTWIRTGPPSTGAPTSPPTSSGAPSILVPTIDIVEDLEVYLFGMLSCRNYCLNAFEAKLINHIETFYASSTGSFQVLENIPRITGVGPIFMADEEDDDDGDDDDTIVDTADGDTRKLQVEGNQVGVRIIYDHTFEWFARGSGIMVEQLAGLPFASEDSRDAFVASLKQFNVFDNMTEISSIVFPEFTSAPTSEPTEDTSTRPPSSTAGANQDVVPQPGEVYSIGVIVGIAVGGSALLLLCLFCFCYAKKKNKDQGSYAPPGDDFSFGFSTVYTKEQEPVSRNYNPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUA5</accession>
    <name>A0AAD2PUA5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUA5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1949129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="109" mass="12248" checksum="486705EC4B62122B" modified="2024-05-29" version="1">MSESFEKLEVTGFLEDFLRCATVPFPDPESTDWNEMLLDMRYSLKVSAPFLYERFQKDELCGDTLQAILNGRDGSRSGMPSQVEKRLQGIASAMVKTRTSPPDCCSKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWQ4</accession>
    <name>A0AAD2PWQ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002097">
        <property type="protein sequence ID" value="CAJ1962185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="234" mass="27016" checksum="AB1850A6800BD8A1" modified="2024-05-29" version="1">MLQHEELFEEAPSEEDDPVEFDKYVGVKIRKNENGIDKFGVVCGKKRRADGLMVGSYHEKPVLDTSIYEIKWHEGETESYRANKVIEAMMMNVDNDGNSILHVKEFSDHRTDGTRVHADDGFVMVKNKKVPRRTTKGWYLCAQIHGEEETEWIDLKTAKEAYPIQVAEDAVANKLVSEPAFSWWVPYTLKKRDPYTLKKLDRILKAVKRRALTRKTEKSLCYIGEAWNALHAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXG5</accession>
    <name>A0AAD2PXG5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS21880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002269">
        <property type="protein sequence ID" value="CAJ1966297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1966297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="136" mass="15370" checksum="9844AFAEA09C7A27" modified="2024-05-29" version="1">MAPNLKRTQLLLQTVDLDLIQPVKAGFPTLTSEVAHQSQKVTVQTPQQDSSSYWEWSAENDAEINKLVEEESLSADNIVANILRQAAAPASSTLAANDQYWDWSHAKTESVDYWNWPADNVEQSQESIESDSYWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY26</accession>
    <name>A0AAD2PY26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002425">
        <property type="protein sequence ID" value="CAJ1969734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1449" mass="154392" checksum="92BCE167D4A22007" modified="2024-05-29" version="1">MVEDKDNKKLIILKRIVINDTQDEDTPRETKEDFEGKLDRLTKLENAALLIQRNARSRIPALALASLGSSRRKVGFGDDVDIWNIDEESTSDGSSNDMTVHEKEEEGNSSMFTLLFVACGSIIMMLYSYMGCCMKSCFGNNFEDDERDGYMMDAADLTEVSMNQTQNATTSQAAAQAVTPGGAGGSGAESAAANSAAASVASGVSSGIAAGAVAASAAGMMGGTVVAATTTTKIVTVAVVTAAAYSTYQGVELLTPPEAQIPLAFSSRCGIENPESRSGDFTLFFDGLARGITEREVALFEGLVVGAYNNLTFGSEFDESTETYRCVDEYLREMKESNMIDQIYQEEQGNQSSVLQINMESTIICEGCPAELPIFGTVEETAPLPIERYLRRMSTTGEIFDISFIEQYLRTIIESLFELMNEGELPTNFSPSKIYFRGFSRGNQTDGSENLIFDEQAIEVDIPIGVYDDKISGAIIPVFPTASTNQNNGIDFHEGNFSMSLTGVSLSRPFTPEESIMLEKLFVEAYNEVTAEAGAEGGEASFSQLREMARASLIGQQLITGDDGLPALELTFKGFVTCEGCPADQSLFGDINGEGLDLELIQKVLQRVIVDVVKAIEDDDLPAEFLPAELSVEDDATDLDLVNVPIFTEVGENGTIKVDMPDLGLAPQQFEDEFFISFRGFDRIFDSDEGKIVEELLIEAYNSFTLGSNSTNSTNTYSRKMVDAVLKDQILTNGTSEDGDVSTLDMILDVTVLCDDCTSDEPVFGLPGAQGLLDWTFIEGVMINVITSMMQKIQEKELSDSFVPDEITTHTDDTQDFFVSIPMESYFDPETGTWVFELLPTIVELPSLAPSSSPSPLPPQQFEDEFFISFRGFDRIFDSDEGKIVEELLIEAYNSFTLGSNSTNSTNTYSRKMVDAVLKDQILTNGTSEDGDVSTLDMILDVTVLCDDCTSDEPVFGLPGAQGLLDWTFIEGVMINVITSMMQKIQEKELSDSFVPDEITTHTDDTQDFFVSIPMESYFDPETGTWVFELLPTIVELASMAPSLSPSPSSMPSEAPSGVPSNFPSFSTTTAVTTEPSDAPSSAPSLSLVPTQQPTKRASRMPTPAPSIAGSGAPSSTPSSSPSSSPTSRPSATPSIVFSGQPTFTPSSRPSRVPSTMPSKSPSASPSMMPSTVPSIYPTVLESVSPSASPSTSPPTDGPTNGPTPATPEPTKSPTSGPTNGPTPATPAPTSGPTDVPTPGTPAPTDGPTNGPTPATPSPTRSPTSGPTSGPTFMPTTKSPTSGPTSGPTKTPTSGPTRFPTSSPTSPPTIGPTGTPKYWMTCGNAFTLAPCTGITAQFVDPLAIGMDDGTGFVMETGVRCCADSPPANNWRISRNSVWANDGDAATNCPYAISPGSCSKAQNFFQAEAICAAAGGRLCSRAETEAGCAGGAGCNFDTYPIWTSDSNIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY86</accession>
    <name>A0AAD2PY86_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS23673</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.780">
        <property type="entry name" value="von Hippel-Lindau disease tumour suppressor, beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037140">
        <property type="entry name" value="VHL_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036208">
        <property type="entry name" value="VHL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49468">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042057239" description="PPIase cyclophilin-type domain-containing protein" evidence="13">
        <location>
            <begin position="17"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="14">
        <location>
            <begin position="103"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1467"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="613"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="982"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1176"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1467"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1491"/>
            <end position="1502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1969374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1510" mass="168481" checksum="C4F6B6080B5935C1" modified="2024-05-29" version="1">MLVSFLLFWLANLVSASNSAEVAFVNFSKEEVVVYWKNEKKENDLVKVGSLMPYESFHLESFTGHVFVYETKDTKGTLAVEEETHFFALGPAELLVQCSTTEGDIHAHIMPEWSPLGAARFLQLVDIGFFYGCALNRVVPQFLTQFGISASYDMRTAWRMESIKDDPPVDVPFRPGYMSYAGSGDNSRSTEVFIVMPGTAQHQLQHFGTNSWETPFGYVEEEDLTTVSNWYAYGDMPPWGEGPDPQIIYREDGYEYLKDEFPNMSYIQTCKIVGPVLGEAEEELERGPLNPKTMHIQEIVIDGFKSYAHRTVVEGFDPQFNAITGLNGSGKSNILDSICFVLGITNLSQVRAGNLSELVYKQGQAGVNRASVTIIFNNEDEAGSPVGYEQCSEITVTRQVLLGGKSKYSINGRNSSAGQVQNLFHSVQLNVNNPHFLIMQGRITKVLNMKPIEILGMVEEAAGTRMYETKRVAAIKTIDKKQAKVDELNAVLSEEITPTLERLRGEKHSYLKWSKNNADIERIERFVIASNFMDAQEALDCNKEGSDEMEVQVTALEEKAKEYESQIAEKEEEASDLSSRLKGEFDDSHKSLKQEEEKRSKELVKVISSWKNKKELTKNAESDLEAAKKLVEETQQALQQKKNEFAAESNSIETRLNAKKEAEAELERLTSDFQSMSAGLTCSQGDDGMTLPDQIAKAHSDSKTAEAKVKQATMKMKHLTKELGTVEKNLKKEQKSASDLNAKRDSAVEKEETLSAAVSNLEFDEEEFSSLEQEKDQLSANVAEWSDIVEVLSAKLGNRLAFRYADPVRGFDRSKVKGIVANLIKVNRAVHSTALEVVAGGKLYQVVVDEAITGKAILDRGKLERRVTIIPLDKIRPRKVTDAAARRAADIAQSLKTEAWPAIELVGYDEEVRAAMEYVFGSSIIVDGSKAANQICDSTKTRTVTLDGDVYDPSGTISGGSKDNLGTTLSELTKLAEISSKLEEGQVRLSEVRKKLDVLKKKSADYDKLKGKLEIAQAELGAIQKHLSQTSYGVLEEKFNAMTEEMKETEKQFEKMQKEQASKWDLYHELKEREGELTQERENRLGQIENDVQEAKKRVVDTDKSARQAQSTLQTLTLELDGLKTEVLTAEESVDSSKRALEAANTEEDNMQMKVGEVKASYDDAKTALYNFENRLVEVSSQLAELKHVKSSLKKKADDCTLQAKKISVTISRIQKERASAEKLVADLLKNNIWIESERSAFGVEGGDYDFTATDPSEMSKQLQSLKSEQEALSKKINKKVMGMIEKAEGEYTELLRKRKVVENDKKKIKSVIEELDVKKKSELERTWKKVNKDFGSIFSTILPGASAKLEPPEGMQAWEGLEVKVGFGDVWKESLSELSGGQRSLLALSLILSLLLFKPAPMYILDEVDAALDLSHTQNIGNMLKTHFSQSQFIVVSLKEGMFNNANVIFRTKFVDGVSTVARTIGTGSSKPRTLTQSAENETETQQTTSRKRVARAGNRSRGKENSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBG5</accession>
    <name>A0AAD2CBG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nephrocystin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1906254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="613"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="904"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="936"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1906254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="107768" checksum="ABE70D862F92C625" modified="2024-05-29" version="1">MSKSSDHILEKAIIRCKKAQAITRPYNEDEMVKAGTLAAEKLDILLEMSKEGDFGELGEQLMILDDMVKNMQLAILEPLTDSIETIERRMNAYISAVNEEEVKSSDATSAERSQEGESDEAAGNRDVPRQSADTESEPMDDVTVQQQRFFERLHHFFEFQRIAEEKMQMIDPSEKLGTIKLKAHSKGIQEKDGTFKSGYRQQDGNGKTIKYLSDLYAAANEAKPAFQDVLNSLLQDLPQLNANSVQMAPIKDQARATEKAQEEYTYRIPGPREAWLFDILRASVTCKTQKQMSDVNKWLKENVHIVDCQNRFALPQFDGYRDLLYYISVPYKEELAFVCEIQVHHFDFKQQFGVNSHRPYFRPYFSGPWREPFENLRDLDMLLQVGRVDDNLMEFLLEANDSSQLKLFGRLFFEKLEETDRALELFKRVLTMEETALGKGHVITGTTYQYLGLSLLKKGDADSALMYLREALAVSDANLGSAHPEIALIHSQIGDALLMKGDYGQALIGQTETLSIRESSLGENHLLVAESYLKVAEVLLEQGDYRKALAECHTALTIQESILGDSAAEVAQTRLSIGEILEKQGEDQKAAEMNLSALSIFEKSYGRKNEKVAEALSQVGALQAKKGLYKEALSSHQRALEIRESLLGENHPECAKSHTFIAFVLDKTKDAEGAASSLQVALKIRGKSLGRYHLETSNSHFDTGILLLSNGDPQNAMSQFKECLTIRKSLCGRNHPLVGQAMNAVGRSKAQLGRLDKALSDHEKALAILEKAVGPNHPWIADTYQYFGEIQNLMGEKDKAFESHSKALGLRSELLGKHHPETATSCLLIAKLLESKGDLQGAKVAYRQALSSYLVLHGEDGQATAQVRVCLGRMMVGQLNFEGAEEELAKANAVLEGNDDLLAAEALSLLGTVLSKREDYDGALELHKKALKIRRRVHGDQHPDTADSASKVDCARSKNDEDEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CC54</accession>
    <name>A0AAD2CC54_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 11">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 11"/>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1904705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CC54"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000028">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="142"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1904705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="496" mass="56209" checksum="1CE99334C6EF2026" modified="2024-05-29" version="1">MISGSSESKEQTFSNRVLKWTKKMSSMATVCGSTDQLNNIAPSDSFEGMVEDKPEGKRVPSRGYHNTSKGMKVTKASSNDSYDHDHHTLATATTATASFSENEHDDGSYMDLSKRSERRAAKPYSTHSFPAGKHTFTVDTRYSMNRVVGSGAYGVVVSSHDSRAAEDVAIKMVPKAFNDEVDAKRILREIKLLKHFKHDNIIQIVDMMPPNARYLEDYHDIYMVTDLMETDLHRIIYSKQKLSIEHVQYFAYQLVRGLKYIHSADVIHRDLKPSNLLVNSNCDLKICDFGLARGIHPAHGEDASGTMLLTEYVVTRWYRAPEIMLACHEYSKPVDVWSVGCIFAELIQRKPYFPGDDYIDQLTIISKKLGKPSDSDLDFVTSEKAKRFMRKLPSDPAPPLSSQFPGTPSNALDLMRKMLSIHPRKRIPVEDALAHPFFAQLHSADDEPVAEAPFDFSFEKEKLHRIRLQELIWQEAGHFRPSCLPVAPRRDGLREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCM5</accession>
    <name>A0AAD2CCM5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CYCCA115_LOCUS666</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1913734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="19">
        <location>
            <begin position="368"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="578"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="744"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAJ1913734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="802" mass="89439" checksum="0CBAADD631CE4C0C" modified="2024-05-29" version="1">MSSSEEDEDILMNENLPHRQSDADDNDDDDDDDDESNNNNDDAAAATSTTRKRGNRNASSSSSPPTSQPTTIISDHDEDTIRIMLSTDNHLGYCEGDAVRGMDSFAALEEVLWLARHYNADLVLLAGDLFHMNKPSRGTLHKTMDLFRRYCMGDNPIQIQILSNQAQSFRNGTVNYEDENYSVDLPVFSIHGNHDDPTREAGSTDLFCALDLLDVANLVNYFGRQEKIDQVQISPILMKKGSTHLALYGLGSMRDERLHRMWRSQQLKFLRPEPPPEGESAAWFNLFALHQNRDFGRGTKNCIQETMIPEWMDLVCWGHEHESSVEPSESVVGTFRITQPGSSVATSLSAGEAERKQVGILDIRGTNYRILPIPLTQVRSFTRGEVNLADIQGLNPDGPKVDREVTEVLDDRVRVLIHDAREKIKEAIEEAEEKGNVLASMENLPLKYTLQKPDSVLVRLNVDHSGFSVLNNQRFGAKFVGEVANPTDILLYSRKKSAAQRKNTSKKLSEMEPIEPDELETMKIEDLIVGELENADQKMEVFDEKRMTNALDSYVDKQEAQAIPEAVETLLTKEQKRWIKKGSTPSKAERNSKEEEAGTTSKKKRGRNAIAKDEDFGSEDDEEPAEKKAATGTKKKRATKAAPKAAAKRNVSNSSDDSEIEEVEDDSPPPPKKNGTRARAPRKVQPKYTESSDDEIEEVDPPPKRSRGAKAKATKKASSRAMSDSDEDIEVLDEAPAKKRSRRSSTSQSTSGNASLSQSQLSFAPVQRRSRKAAKGRLYSNDDSDDMEDGWGTAKTMTNDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CE18</accession>
    <name>A0AAD2CE18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000163">
        <property type="protein sequence ID" value="CAJ1931600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CE18"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="304"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="368"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="432"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="496"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1931600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="561" mass="65198" checksum="21439CEA561D98A2" modified="2024-05-29" version="1">MILHLFSRRHPNSIGLGKVAEGRWKRFVMSKAMPSVPGNIRVSDELYLQIQRLCHYSQRLPNINVFGTTLRTFTSISKPVDESDDKSSPVGTKIIEIDTISWSDDPAKWLKETCMSYQFADKKKSTVDKLLPDQWMNTHNASHWMPRIMKAMWKKRNLGTDADDRYVCDFMALCEAVNRLEDATDLEKIAANLLEKIIVFQSHASPEKHCEVHHTWPVCALGSTEDPRNYKVVSWKAHLLCHVALASLFPSIRGFNLTVARMLHLGESKLTEEEILACLEREELVGAAANARERAYQDLLDATQRQWDNWFNQLLAFKDEHGHCLVPVSFPGLGMWVAKQRCLSRKDILSDDRKRQLEAIGFVWNPLDEQWDGMMEQLAAFKDENGHCLVPRSFLGLGRWVDTQRVLYRKDILSDDRKRELEAIGIVWNPLDDQWDNWFNQLLAFKDEHGHCLVPRSFPGLCRWVDKQRGLYRKDILRDDRKQELEAIGFVWNPLDEQWDNWFNQLLAFKDEHGHCLVPVSFPGLGMWVAKQRCLSRKDILSDDRKRQLEAIGFVWNPFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEU9</accession>
    <name>A0AAD2CEU9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000102">
        <property type="protein sequence ID" value="CAJ1929948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEU9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="574" mass="64299" checksum="D0B89EA1A6C3836E" modified="2024-05-29" version="1">MIRRMEYDDASDSSSNECSEAFIIDCESCDSSVSSISMYDLDDLSSSSEEEDDHKEGIRNRNKTEKKNPCVDLGLTHMNYDHQRRTRKTKPEKRNTVESNTGESNAESNTAVAYELRPRKRRSGTRRGGRRSDSKEPSQNNASIRSHSSIDKEKMLPEEDRPSHEKRPSMSEMIMRDMVSSLDKGMLQDEPAQEKRPSMSEMVMQDMISRGLFDDEDEESSEDEDDSVESDHDEVVTAAVDDDSDCWSESLRADLKSPKSQHTTKKLASSVLPSSTVGVTWPNLRRSMTPEQRQLGISDHGTIHDMDSDGDSSMDNTMYSGGSSSTSLEYDSGRESSKSSAESESESSFEQESLTNHSLSSRIASMILLSPIRRSQSSHGQSLPETLQQLENNEEVPALEESPSSSHSSIIQSTSNRRDSYRSVSSAEVTAKRNQVQNKLEQLDAHMLKVFGKQSAPELSETTRNMIRDHLTGSSNQYTKTKDIIMTAANGYRISNKSIRRESQLYHIGTSHSATSLSFQASSRHQDTMLNHLLQNTSSKSTSDLSSLEAKRSNAELSRRKLREAFHTRLSFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFC6</accession>
    <name>A0AAD2CFC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000236">
        <property type="protein sequence ID" value="CAJ1933081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFC6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="150" mass="17585" checksum="80DD6AF86B7C33D0" modified="2024-05-29" version="1">MPSEARNQRLVDNICYVFNDMSRTEDNCRNGVAMVLNTKGFIDGRNHNEESISLFAKAIQGKLVPTKVRLILVVGATKRFDNSWKQMKELLSPEYVKRFQFISEDKLRDYLMDGYEQFLPNELKGGFRDCMEMAEDYSDLKMYEERSQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH41</accession>
    <name>A0AAD2CH41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Acyl-coenzyme A thioesterase THEM4</fullName>
            <ecNumber evidence="19">3.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Thioesterase superfamily member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">CYCCA115_LOCUS2002</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40151"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40152"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:40140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the THEM4/THEM5 thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="19"/>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052365">
        <property type="entry name" value="THEM4/THEM5_acyl-CoA_thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418:SF19">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thioesterase" evidence="27">
        <location>
            <begin position="136"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CAJ1930615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="227" mass="25500" checksum="EBCABDDCF382F87C" modified="2024-05-29" version="1">MWNGTWKSAQPLRRVLFAAAFSTGAYGFTMHRDRFEKFPTTALSPNFIFSALGMTAKESERQTRCESTNTWPDPSPYKLMEVPDRTPEDKHAIFDLLLGNNMIEKYEVYKRPTGSTDDNVVIAHIAFGEHLDGHTGIVHGGILSLMFDDLLGFGFYSLGIPMAFTANLNVDYRSPVPAGTRVRVVAQLESREGRKLFWKAQMTSLDQQVLYAEASSLYIIPRSHAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHA9</accession>
    <name>A0AAD2CHA9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHA9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="828"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="964" mass="105109" checksum="AEBC35AB50AF3FD0" modified="2024-05-29" version="1">MTVSITPSSLPGSKSTLKTDNSSYGGGFWSLNSSSVHSKEDGGGSSTSFSLTSKNNKSNKNGKNGKNGKNKEETSNKNGSPKNGTKKGPLHLDNSSKPQPKQQQQQEEESKGQQEANEKPKIRFAPYAKQRTILCREDYSEEEMASCWYTQNEQLDRDEDIAVLVEQLEMEQEEVGELQDQSILRGLEACMEEGKEAVDVVVTTCIQEVLHVQEQRWNKLEASQELTMSPTPLESKMSKHSAYWELKMARASRKASQQCMEFALEMAQYDHEEALEAYRQMEKKHAKQQAKLAKQEQQQQLMEQESKQTKKKIAVVPEGSESGRNLERKESLELEPLVMPLPPPPPPPPEEAPPASPITKIRKKKKDMGDLDLSASLKDSSSNNNNKKKKKNKIRHASMSNTVGTSEEESSLSQSLSSSGALSHSFQSSHGRKKSKTKKARCKSVGTTFDISKELGSSSSPSSLLEHHLQLSPNAAGKKAKKSKRRSSLTAASSSLSLATSPMPVTHSEDDFTTTTTTTTKHTKQAKRRSSMSAAISSSSSNALTTSEEFAKFKRISEDFVRGNNNNNSDSKKNAKDHSEMSAASSVASAASGDSTATPPTISEDFLLSDGDGTKTKTKKTKRRSSASVATISEDFVLQTPPPTTATINATTKTPSTTISQEFALGNRNDESISEDFALSDGDGKKTSKKKAKRRSSASVATISEDFVLQSPPATSRATISEEFALDLSAEDGKKSKTKKSKKKSSSSTTALPPPPPPPATISEDVALAPLSPGFISEELELGGERNTAMVSTELVKKNKASRHNNSKKTDASLLLSPTTKSPKKSNLSPTIKSPKKSLLLLSPKLKKEKTSASSSLLLLSPKAKKEKTSGSSPKKEKPPSPKKDKSKEEKKLAKMEKKLAKEEKKNKKKKKKNKGKDDDDNDANDNDDNAGDDDTNSPRKSPVAKVKGMYNRIALNSFYKGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHD0</accession>
    <name>A0AAD2CHD0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="195" mass="22901" checksum="4D4A261B11D7B802" modified="2024-05-29" version="1">MPFQEFVNSGFGLWTPDCTHVNRVRKQRREFESVLSQQSVNSEERESNELRGHDEVGEDRDLEDMALSLVENRNDLLKHLAKTVEAMKKLEAENEKTRSENDRIRAENDQLKTENEKWKSHVESMITDTRVSLEEIRRQAGETVRLQKENEKLRNENTYRHLIMQQMKKRSEMEAKTAKTAKKNTSVFDMFGPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJ65</accession>
    <name>A0AAD2CJ65_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000448">
        <property type="protein sequence ID" value="CAJ1935333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJ65"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="114" mass="13299" checksum="3C7459F6ED03B556" modified="2024-05-29" version="1">MAAARIAWRNYIRDVLNFFQDEAQETVIEQGFSSPAFFARSTRKNIDSLVKQINRTVIDPGNDPDTTFSINQAQKIMLYDLCDYCRFIIWWIANMIQLLGHKQIWQKSIAIIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJA9</accession>
    <name>A0AAD2CJA9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000479">
        <property type="protein sequence ID" value="CAJ1935482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJA9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="116" mass="13225" checksum="B1B839463BD3A146" modified="2024-05-29" version="1">MNESLGRQNLVLWLNILGFWVCAVPIGAVLTFVVDMGVNGLWWGFNIGIYTSAAVGIWFLKFRIDWEQETKKTVDRLSTLKKSDETKSGSTEPTEKRDELIDEPKEEAMLQEVQNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJM8</accession>
    <name>A0AAD2CJM8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJM8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="326" mass="35299" checksum="70F8927EC05CAEAD" modified="2024-05-29" version="1">MRTSAFTRVKAASAVLQQCRGSLLQGTTRRNLSSSSSSSSTYYDSQSGMHVPVHNVQEISIILDRSQEDSNLSTSFVPAHLYKEDPSSDMPAQLANLHSQGVQGVILPPISFPRDVRNLQTLKHIAPSKDFMFFASAKDVSAAAPLLLQQEQQEEENNSSSSVSLILKFDAEDSNINEGSMDLQKIHDAVGGNTNTITTKVNTTIVLSNIGKEDQNPISIANQVAAWIDANQGGDFIWVPSTCSADANVDSDALERLCEELSYLDLVGKTVASRLMIGGGRMDSTINDELVNETMFSGVNKFVVSNEDDISLIAEIAELQGKSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CJZ9</accession>
    <name>A0AAD2CJZ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CJZ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1936367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="381" mass="42811" checksum="641217B9E388A6D9" modified="2024-05-29" version="1">MPFLSRQLSNCVNSVNSSVNSSNRLGATPAAYLPDYLPSLRKEFKFVSDFKEGFNRVHYDYLNLFWTYSISRAMRYILPFFMVLASTRFFVPELGQSLTHGFDLSLRGIYRLSSVVDAMLLLPLKAAYAVATTLPPLMMIPLLEYMPQSAVVGIVSPLLSLRRLVKILGSSFFFSTVGISIWRPVLEETQYRFILSSVLGDKGLRRWFGRSKSTISEESMATVHMDKNDLPVSKTTKGKISKTCLWTSFFFAVTRFGWLCSNFDDGSTSPYSWAVGFSLSLLGHLSSVSLSEVRPVLQYALLFLSLHQAVSTFLVAVNIYEPMYREKGLIASIGSHVAWTTGIPTIPFRIAKRIYDGSKKNGPNTVMTEMCIDCENENKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CL06</accession>
    <name>A0AAD2CL06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CYCCA115_LOCUS5058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CL06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="74"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="464"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="534"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ1936171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="76261" checksum="E5927BE4A9364E0E" modified="2024-05-29" version="1">MDSNDPYRLEPLKTEVTSSLRRRKAGTRDGFLSSSDSITTTNSDRSGDSLSIPLPSLHGSLMRTRTEKDPYRYYEIIKVLGEGSMGNVCKVHKLKSMMGGSARSEFVKQEKQRSWLWCLDFEFPCFGICPMSKKEETKDSLLQTIEENAPSQDKTTPMVPSSINNHNIRTSSESSQISTSSSIISYGRKDVTYALKSIHVDRVRDSVFRKELMNEIIILQTLDHPNIVKAIETFDYKNRMYLVLELCSGGDLYSRDPYDEEQACGIIFSVVDAVSYMHNKGITHRDLKFENIMFGHPSTYSVKVIDFGLSRKYATKEHLHDTVGTVYTMAPEVLKGDYTSQVDLWSVGVIAFMLLSSSLPFYGKNRKQVVRRILRGSFTFRGERWNPVSSAAKDFICKALSRAANERPTAKEALQLQWLKRLHSDVPVSWLLMDNVSASIRTFATYGKLKKLALLVVAYKSTDEELGFLRKIFDKFDITNDGEISIVEFKEALTVYQYTDEELDFMFQALDIDCTGRVHYSEFLAGSLEAHGNIDEARIAEAFDRLDSDDSGFITVENLREFIGHNISGEYLDSIIEEVDRTKNHKIDYQKFLDLWNEQSASNLQDAMVDVYKRRETFESEDLDLDVSRSASFDSSNDGDPLDISIADPECKGSYFFAKEKEKSTRGVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMD6</accession>
    <name>A0AAD2CMD6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000535">
        <property type="protein sequence ID" value="CAJ1935977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMD6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1935977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="167" mass="18548" checksum="5B62860BD5F5A969" modified="2024-05-29" version="1">MGSLPSLTYLIQSLVKCSVLSTDIQDSRSSLLVAAFFLARSIGVTTPNVSAFMANQVLTASSFLADQVSFMMSQATAASAYLFTATSTVIAVFEGSPTNRLAPLLWYKRYIQKCRRQRRPTSFSHCRHTRHYGLATCRRLAQDLRISPTYHSVFGVSHVLSFLSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMP4</accession>
    <name>A0AAD2CMP4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000413">
        <property type="protein sequence ID" value="CAJ1934920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMP4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="100" mass="10817" checksum="809466DED3B668AA" modified="2024-05-29" version="1">MGRSSSGGGRGSVTLQKFKSNSSSTVVKHPFSTKDENDGKARSSYKDAEERVLIDYIQASGMKCSEDMVKSIRDGKSIDFNAIAPRLNAPTQTEAVARET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CNJ1</accession>
    <name>A0AAD2CNJ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CNJ1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="701" mass="80173" checksum="BF3A0C2E4737FF57" modified="2024-05-29" version="1">MDDNHYLIEWIAYHYHAVNLRNLIIVNDEHSMTSPYSVLERWNGRMDILQWKDEHYMDAAEFKAAQQEVINYFGNDMPPSLVLHRARQRLFYYKCLQNLKARGKSWVLLTDSDEYVRLNYDLIGKSNLQALPMQEPGSVSSFLNQHALVQSKDDGVNKKEDSSPIQMLQSSPCVQVPRLRFAGGEESTGLIHENYNASDFLTLRWTSHAPPTDYKRNKISKAIVDVSRIPPQDLLPVDSIHVPVRAVCQQRRLHVRMSQSFLVIHHYLGDLSQYLYRENDARTLRSADKYAESKSLVNPQVSKAMQPWLNGFLTTTTTTTTVDQSSSNHASPLNIMGAKDLLANVGKLQPKSWQTYNGPENQDRCALCFFGLPRAYKTLVLPSIVQNLLIPNARHNCDIYVHYYKQYEEEAGRRNRGGKINPDDIFLLEEVAKETAAKYGNKDGRNAGRVPNIQFTYDTDEMFLEKRKELLEKYHNTMGPDGKPAYFPWGTKTYTSTSLDNMVRQWHSIEFAFKLMDFAGKQNGVQYSRVGMFRNDAMFLTPIDIALMDKGVADTKNMVFSVAPFARYPINDRMVYGPYNAIKIWSTKRFELIEKRVQLAQDPGFEMHSERFLNGTIFPAMEAVGYKMEMNRDVCFVRTRADEAALANDCTVGGMTRGFGSVNKKELVESIVGKNCTSYKMGFKWLGVGCGDGIKYFDGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CS38</accession>
    <name>A0AAD2CS38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS6469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000779">
        <property type="protein sequence ID" value="CAJ1939183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CS38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042249316" evidence="2">
        <location>
            <begin position="25"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1939183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="306" mass="33584" checksum="47D1E030607CC391" modified="2024-05-29" version="1">MGAAKKFTVYLVLFVVLMIKMNSAGLSQKAPLRPAARAHPAKVPPSGNASTTTTTTTTTTNEQTQRATRSSNAENIDMTRTAYLLTVNLTSPRTIRSTAILKGVGFTVHHAMAPFLGTERIDKTNSNKLAQMEVYRIIAAGTQPWGYVFEDDIALCRSKEEPEESQFSVQRNLICHKNNQDTCMESKHALGMFLGVCGSKEHVGKEHPGTKPGTPLYCGRCVHSYGVSREGASKAIEYVEKCDADQSFCGIANRQYMDVLIERFCGYYGGFPVSDMECAGKKFKKHKGSFIQDREAFQTILGSPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSG5</accession>
    <name>A0AAD2CSG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS7844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSG5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="759"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="806"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="820"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1942232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="836" mass="94825" checksum="2F8F1E7B4C4A19A2" modified="2024-05-29" version="1">MAKQSKRTRKFVQSGGVKARLEKGTINKKGKVKNNKKKGPKNDAQEGIDAIKEAKANNYAKGLARKREEADFVSQKNLGDLDMESFFSEFAGGVDPDEYDDAEEEAAADNSSDDDDKEDSDEDEEAEAEAEEKPTKKARKEAQQNHERSDSDSDSEEEDVEVLEKRMKSEMGKLESEDPEFHEFLQENDGSLLQYGQSAEGDSDSDEDHDMAAVEDDEEGDDDEEKSQPIDGNAMRLTPAALAKLEKGAFQHHGIKNLRKLVNAYKSACHLTDGSDSDMRGQRYHIESSKVFDRLMVVALTKVHEEFHYHLLGKGSTQKNQLPKKKGVKKSADEDAEDQEDEEMDPNKPINPKTLEKSQRWADAKPILMTFIKATLHILSEAKEPDLVVYVLKSLSNYMPYMTPFPRLAENFLKTLTGLWSAPIDASEDYQVVRLHAFLRIRQLALTQPFPFIEECLKKLYLAYAQRAKFANAASVTSALPTLTFMGNCLVELYSLDYHSSYQHAFVYIRQLALHLRSAMQKKTQEAMATVYCWQYLHCLKLWVAVLTEACQSDESGAGGSDDQLLRSLVFPLTQVILGTVSLIPSTRYLPLRLHCVRLLQQLAAASEQFIPTTSILLGCLDLKEIYQPSKKTTKGGVQPLALTLRLRADSPLRTMDELEMCISEIFLLLNREVDLYQYSPGFPEFSIRISQRLRKFAKESRSPRWKAYARGCLELCTKYHERGVNERAKLNDVAPRDVKQLELLRPIRVPSMGARYKESLEKEKRLEAASRPLQKTAKKVKEADVEDPDEKKSNKRKRSKKKKKAEAPKMSDVPKDALEQEDEVHEGIDWSDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTA6</accession>
    <name>A0AAD2CTA6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor beta propellor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS7953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTA6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="6">
        <location>
            <begin position="238"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1942450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="637" mass="69568" checksum="E20443EE0B4E5B21" modified="2024-05-29" version="1">MASPPLPFNRILLRSREGLEVFTLPSERDEESSISKRETRKFLFKGSSSFHQILPNGSAAFVHKPEVGIFRVNLGDSATDSDVPFLENTARVQIMAISPQGTFVLTWERAQEGDAPNLKVWNSETGAFVIGFRQKALKRDSWPYVQWTNNESFAFLLGTNEVRVYPGKFPESANTRFVDKMQIPGITSLSLPSNAELQGKLLFTSFCPGDKNKPAKAALYEYPAAEKTSGPYPPILSKSLYQAEEMSVSWNPKGDAALVKLQTSVDTSGQSYYGSTSLFLMSAQDKDTVAVPLPQEGPVHDVGWMPNPSKPACFAVAAGKMPSMTSLHNGADGTASFLFGNAHRNTIAWAPHGRFLCLAGFGNLAGGMTFWDRNKQKQIPPANPVTASCTVGYGWSPDSRLVFVSTTSPRMNVDNGVHIYRYNGDKMTNLPWDNNDYVPNRLLQAEFVPAKSIEYPDRPQSPQLKDVNTPSAAGAPAAAKPGGRYVPPSQRAKAGRGGSSLADRMRAEREGGSVAAGKVKGKPKVTGATGKVVVGMAPVEQKSKSALRREKAKKKKEEEAARQALEEKVLAEAKAAEPAQPEQAAVDPEKRAKKINKILRQIDELKQRDQSSLNEDQKKKIESEASLREELAKLGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CTQ4</accession>
    <name>A0AAD2CTQ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS8911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CTQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042107839" evidence="2">
        <location>
            <begin position="26"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1944485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="320" mass="36434" checksum="12CE35D1B739F26A" modified="2024-05-29" version="1">MKPRQNNAALILFLFLSVSLTHVDSVEQRNDDTEERSEAIVSIPKKKFDYAIGCSPKKRTQFVSLYDKALQVTGDSTFSRMLEHEQVLQEEQSQKLALQQQGNGEMSSFAFPYSSLFVPVLLAFATHNGFSISFEDTFKKLRNLILVAWLPVLLFNASWIEISSFALLLFRPTVWSFLVDEFFTDTWTISKKLLLSELWRHFWKHTTHIFPIPNLSPSDEYLELTPDWFQMGFARVTKLVDKFAQGLVRKSIERCFQESLGITVGALSEYFLKNGHDDSLGRLNKLDAASAACEQSPGESEVEAMVVERAIERAVESDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CU35</accession>
    <name>A0AAD2CU35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="3">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS5187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CU35"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="9">
        <location>
            <begin position="90"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="141"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1936429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="32197" checksum="AAC9EBBABE6079E9" modified="2024-05-29" version="1">MSTSSSAIFLGPQQLGSFEVLALDESIISQRNVALVDYSSDEAPYVPFETAWDWQKDILEGHIERLTNTPEDSSSSTSIQFLSPTDSINVRGADTVIMLQHEPVYTLGTGSDEKFVLGLQQQQQQETSPSSAAVPTVRMDRGGEVTYHGPGQLTVYPVLDLRGYHQDIHWYMRALEEAILLALSKVGLDRAERQEDVTGVWVDNYKVAACGVKVKRWITMHGLAVNVEASSLENFKGIVPCGLEGRKVGCINQFLDEPITVSEFAQVMKGAIEEVFEIRLQSIEDSRLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUN3</accession>
    <name>A0AAD2CUN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUN3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="536" mass="59987" checksum="C9DDA316D846DC5F" modified="2024-05-29" version="1">MTLRDYQQTENRAPRTREASPVPSISRVVTPTKSNSSDENRGENFFSIQMKPSQSNMNENSKPSPAIVEPDFVHQPTREGKYSANSPMRPSAPQLYSLNNGRKSSGQRYDDESLSKKFQQANSLALQKSPESSKSKKKKKSSRKYDPNAYKIFLLLLQPESKIFELIQLIYMPNDTTVGKIIQMIPENATEAALGTQKYSGLCRPKTEEELIDLDVLASETSSGMVSAKITLGEILVAIPKGYSGTKVAALSKQILSNPKIVKLLKRADPLAPKKRRSRKHRSNRSVRSNSREHVDVLEKHDEAEEIKVESQQKMKLAMEHAAAEAAAANAAVSGWEKEEEFVPKPLVRQDSIGSDGQSLGSSLQDSVDESYSSWSKSFDASFSSKMSICSGVSRRQVRRRDRQAKRLRIIKRSTFVAFLAMVGLYIVDPKEHSKNYAEAAMDTPMGVVGLFQVCFLLLALYKIEKFIRCTSEGNFDSYRKCPFLKASDAAMQRFKGTYASKLKKSGRGHDDDSSLVSKRLRSYSLKTASFRDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CX16</accession>
    <name>A0AAD2CX16_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001613">
        <property type="protein sequence ID" value="CAJ1946142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CX16"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="401" mass="46524" checksum="A31AA9D748DE14A2" modified="2024-05-29" version="1">MFDNNKRNVYGMIMKMCTDHMVDKLEQEADFENKLFNDPVELLMWIKNFMTTTVDTEWEYFGLWKTMRNLIICMRIKRSCCTPRQQGMMLFQHNNNGIHLDSGSTFHLRTNEDDFKEGSLQGIHGEFHYASNVEGRELYREGIDKVFDSVCKLDTLASDNVNSLSNMVQDGFDVFMDTKRENSLFVTKNGTTWQFGHRNGLYTLVNEPAMVTTMFHDHARGLDNNDVQGYCALQSVEKNKEGFTNKQVKRANVARSGYHMMGAPGAELFKLAIWGNFFKNCPITEEDINISEKIYGPSVSTIKGKQKRPTPKAVVDDWIEMPKELLKHNSNLDLCIDIMFINNVAFFVSIDKAIKFRFSTELKDRTKDAIYKLIDKILRIYNHAEFRIKTIYCDNEFKPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D054</accession>
    <name>A0AAD2D054_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001335">
        <property type="protein sequence ID" value="CAJ1945224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D054"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="183" mass="22456" checksum="450151F1E9EE8A48" modified="2024-05-29" version="1">MEEEHFSNSSDDKLSLEDAFKYFEIDDPKEATREAVKKKFRRLSLVHHPDRNNQSQESVKEMQKINNLYEIMEQEFDRREGNDRLYNENIPEEPAENTTKPDPCDPDELGISKTEQKRRRKVHKRRRQKARYKERTEQERQQAEYKRRREEMEEEMHREWEEARRKMEDGRVPKETKRGQTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBH9</accession>
    <name>A0AAD2FBH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase III subunit Rpc25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS1056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1923877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="6">
        <location>
            <begin position="84"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="6">
        <location>
            <begin position="217"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1923877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="343" mass="38257" checksum="C85951DD48C20FB2" modified="2024-05-29" version="1">MFVVVTLVDTIRIPANNLKLPTMVALHNEIDLKYPNRVLMDTGLVISRYKDILKISNGLCVPGDGGCHHECLFQLIVFRPFVEEVCTGTIVKSTPEGIQVSLGFFQDIFIPAYWMLRPSEYDEKAGLWVWTPDYGEDAEDADGDGDNEEEKGDEKMSNDKVKEEASIDTTKPAVKQEDDTADTANTAKIKSEDDMMETESNQGNDDDEKEEESEEEGGRWEMDIGAEIRFKVKSIQFTQVTNTAKGMQATTTTTDHSINIPVSEQEDPSQVSRPQALRKRSTSMDLSECQDIPAAMQIVASICEDGLGLISWWTSGGDGEEDDEGDEEEEEEQEEEEANDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FDM5</accession>
    <name>A0AAD2FDM5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UTP-monosaccharide-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS1989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a monosaccharide 1-phosphate + UTP + H(+) = a UDP-monosaccharide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13205"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140358"/>
            <dbReference type="ChEBI" id="CHEBI:140359"/>
            <dbReference type="EC" id="2.7.7.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the USP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.64" evidence="6"/>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FDM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051748">
        <property type="term" value="F:UTP-monosaccharide-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.30:FF:000001">
        <property type="entry name" value="UDP-sugar pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000091">
        <property type="entry name" value="UDP-sugar pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF9">
        <property type="entry name" value="UDP-SUGAR PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1930583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="660" mass="71944" checksum="684B95B860AB2BBA" modified="2024-05-29" version="1">MTTSTSTVCLPGVFRGGAESRSQLSAVESLSQSMISTENLDLLPERGRAAVLSLIESDVDSSQSHVYGDWPEAGTQDEGKKRLSEQLADLNASYPGGLTDYLSKARTLLKESADGLNPFEEYEAIVPEGESLSFDGEGTMSFAEAEQLGMEAMSGAVFVLVAGGLGERLGYSGIKLSLETNLCTNRCYLEVYVQYIKAMQYLARQKTGRDDIRIPLVIMTSGDTDPLTRQLLKDNNNFGMDDDMISIVMQDKVAALKDGNAGLALDGDDRWSVQTKPHGHGDVHHLLHREGLVDKWEKEGRSHVVFLQDTNALVINSVVPTLGVSKAKGFHMNSICIPRLAGEAAGAITRLEHKTDPSKSLVINVEYNQLDPLLRSQGECTGDVADETGYSPFPGNANNIIIEMGAYAKTLRGEDQGVVLEFVNPKYKDESRTDFKKPTRLECMMQDIPKLFQKEMKGTANVGFTTFDRWFTFSPAKNALEAGVEAADKGSIAPGTMSSAESDKYIQNQRKLKFAGVDLDVTEPEDLVKVAGIPVTPGPRIILAPAFGITQEEILNKVKGNNKISKSSSLVLDGHHLTIKNLNLDGALVIRAGSESHVTVDGLTVKNKGWELVENDPSKEYEETVAIRGYTMAKHESQEYIINEPGNFVIGPDGEVKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FEA0</accession>
    <name>A0AAD2FEA0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000412">
        <property type="protein sequence ID" value="CAJ1934894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FEA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1054" mass="118690" checksum="F9FBA059A3D47488" modified="2024-05-29" version="1">MTQNKILYSAKLDENMRRSAYFETNKRTVKSNIMLKFVMKAMDIKLRGEADFTTTLEDPIELLQHIERFMKRSADAEYDFLDFWEANQKFFAMKQGTTENLMHFKEQFLRQAEVLQDLYGVAWFRNFAVKTKAYAAIASTDTTARDKFKDDIFEAVLATGFLCNCNRMRTAPLMLDLQTNYCREVDYYPKTVSKAQAMLKIHMDVTKNPGVNLYQGKDQPTKGRGKGKPKDDKKKGSMLCMWQRGPYVSKMPRQTVPEIQWKHPKHYFVYGKKLNLNQIGATIPATATVPGPSPATSIITGGTSSVAGSVNTPLRLTGTTGNQMMQVPAGMQLMQIPTQGDGTVTVPYLMNANGEIAFSGMQLSQQGFCGAQVRQGFDATQARIPQVVKTGYYDMSNVFHDAVKGKDENGNDVYLIPCPAGTTNVELQSDWHYASKSEDLPDLATKADRGMQFIQSHRIERDPFGLLDHVIMDSGCTNTTICNGELMHGLCQAEKELDMHTNMGSRVLDEEGFLGRFPPPVYYDEDRIANVLAMCEMIAAGYRITMDTDFDNAFVVHCNGDRQMRFVNRKGVYVLEQLGADVEPGATETSAMYRRQLSSINKQPHFELSSNKQNGYAGLGMTAKMAMVRKNKEGFTPRQVKAAMEARSAMHILNAPSTKSLKYAIRSGLIKDCPITEEATNHAGAIFGPDTSTLKGKSTRPTPKKTHNDFFSPPEELYQHNRTITVCIDHMEIGDAKFLTCIDTTVRYRSCIPMQNLKTDPVYEALDKIFRRYNKAGFHVKTIKCDRAFIPLTDDMLDDMGITIDPTAAGDHEPTAEQNNRTLKERVRVALARLPYKVVPKVITECLGRRAAKLLNVFPQKDSISSHFSPQQLIDNVNINYKSNMVAELGQYVHAIGTDSSNSMEPRSIEAIYIEPTKGQLIQRVEAWAAAKGVTSMKFFDKKRDLETFQDGDQIAGVDDTEQGYLEEAFDQDYEPEDENARDFNLRGQFDDINDSERNELLADADNDVDDMPEVIVRFQRDDDYESDDDDSGDEGDEEEEPIVADLDHHQESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FFA0</accession>
    <name>A0AAD2FFA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1904505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FFA0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1904505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="292" mass="32386" checksum="643AA88CE76E7944" modified="2024-05-29" version="1">MDPKKGCPCCTFRLEDDLFLPPSLKSNYNGISVSSMELPMDPKEAVDFLSKASPIDTTMILIDSHGHAQLERDADENYTLDNKTTSSQGPLQLKSITCAVEPKDWADTLRYASKSTSVLPALGVHPWYLERLPNNWLEELDFWSTLPQLWHGVFVSVLKEIRDSAEAGEDVSNLLPPAIAMHSFTGTAHHVKELLALEKTIVKDNKTLFYFGFSHTVNFAMCTSEKSRRKGRDAVREVPTDRLLVESDVHASDDLLAGTAGAIAYVAWAREQELIAIASLSSQNGQSFLAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG75</accession>
    <name>A0AAD2FG75_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000513">
        <property type="protein sequence ID" value="CAJ1935849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="261" mass="28453" checksum="33D17AC83C34A7A8" modified="2024-05-29" version="1">MRSTVSFEVHNEPDPMNTETVRTTSGIALTPTPNFDGTWEFLSLQTGHTVVRGAWTVLPTTTDVIFGVNADGDPDAFLHEWRPNVPILDLDDDQVDIALLPPPGGAVPQNDDQDDSSNNDDQDNSSASSDDDQADSSEDSNADDDNDDEADSGDDDDGDDDDGSDALEQPNSNDKGAQEEHAEEQHENETAFLVADLEDAAEHDPNESTQLLQTPLTSLHNDNDTNENNTKADVTARMQRAINRAAAIESTPWRSVHWIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGW2</accession>
    <name>A0AAD2FGW2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="197" mass="21327" checksum="8F315229E56DF8E2" modified="2024-05-29" version="1">MPKDNIIKRRSSCSKVTHQPGASLLRRRKSASAVLEPTSSTRRKTEDKKDQNPLVLGRGSVNVSAGRTIYERASSRRERHRLALKNGLKLGEEDGSNHIVALGRVGARGPNRSSLTKESPEGEDPGLLAIAAADSKRKQAGRKRVASTKPRGYNSLGRAAAASASPSQRNQSIFNAKMKAASQKSKRIPVREKLLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FHF4</accession>
    <name>A0AAD2FHF4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS2604</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000191">
        <property type="protein sequence ID" value="CAJ1931912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1931912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1914" mass="211416" checksum="E79C9CD78DA6BECA" modified="2024-05-29" version="1">MIQWKQRLYAFLLRRILGPFLDSESYQKLHDSIDVSFQEGKFVLKDIGLNADYLTEKLIQSKCPGLSIVNAKVDRLEISLMLKETSTLQGDDNNDSSAPATRNSSFAWRAMKFGTSSTDVPAVALFAAIEIDGITMEVEASSDHRHPTRSRQAPLPTTTPAKTSSSSEAETKAEPSSKGLIGSYVDAALASLQLTLKVTKTQVILRQKPTGTEEFQPWVSFGLSSISYQDVDVSRNPSETKTIFKKVVDVSEITVQAGERKVGVGSVVTHPQSTVALAKGSGQVQLRVFESTMNDGSTTNIQRDVEVNLNHQLHLSVDIFSIQQIKSVLNAVAQASDPVHDDDYSKEPIEINMTSLAGSPLNNNSTDREDIQALSVIMKQYREAYHLAENKQLKGGVLIPTSAYRDDGDVMVEEDPEGDGSFDLFFDANDQSFYNAASVLAESQRIQEESIHKDGESSGDVVSTKVRFHLQRAGVKIVFRESSGGRRSLAMCDEYVLLTMEDLNILYRKSSTSSESTVSIAHLVIEDAQLDRSKRPIGSVSIGGGPIVEGVLDIDTLVGFNSSDDEGEIDQVLFEAPCISVSVKKDINTNEDTPDSVVCEASFLPLEVCIRQRTLANISNFANQVGDSTPKASSKHATKSEKTKQQMVFAQFSCPSITVGIPLSRGVPTAQLFHRHQTVLQNAPKKGTWLGFLMLNNSFEWNAFPKENHPDIMVETGTYMAHHMLMFVQSPVGDVVDVDAAIRRADIFVANGRVEVNPVTPITIEVKRNHDDAGRDSFPLVPSISSFKARQEDDDEDLKIDKLLFSKMGDVHADSRKELRGSDPQFGMASESEKADTVVSVSIPEIAIEATKSEMETVLKVLEALKPVDEPNAGTKTDRLDEPAVASSSSRTCIALNVSKTTVVLKEDVKETGGNEDAFSLLVALDTFKIHALKQGSSTQHVRVLAHDPCVYEVYHKPTEHMEQQSVDEDGLSRIEYFRRRLNLYSSRFTAPILFRSQMFSPMSRESPSILLDYIDTTVEKSSRSSRSEGKRVHFTLYHLTHRFNVDSKWTERLADVLPSRTSNKEESDGLTTIETRKEKREITKVYISLADVNFDYTPPDYFETSSRTILRLGDFRFSSNIITPMTKTQAYSISLGDVSFHVLDQKYPHDRENSSLCRANLVWRSASTTVSSPPTSVLPPTAETLLRELGFVKVVSLDTVDAVILTREKANKAAYEPKTLTCLTFGTLSMSACKDSFSCFATSMGELNAKLTALTDEDIDTLREETDSEEVASEKGPVTSEVTEVPKTFVGPTGVAGNAQKQKPRAQFLDGYDWTTVDHDPLPELPIPEGYEQVAGWYGAFREGQDSPIRNGTTPRIIQQHFPLHAVSDPLSDGDLGASKHAGDDANVKLKSRLIIHQLSVKLRFFDGYDWPSRMSAEQRKAAGRQGSSFVIETLPESERLALKEQQKKEAKAKKSTKAQLLSNLLGPAEETTSTFYAAPLPEEKAAAIEAMEKVRRFSRKPHLFFQLSANGVTLRIDSLENDPSHRLVSIMALSVADLFIAETASGPSPIKMLGEWVNDSEHPHDTRYGTLMMKMVTWHPKTRVTEENEVASDECEMTIQILPMRCILDQRAINFIKAFFHNEEKEGNDSEKWNAGLHYLPPPLFRIARVKPWKLKVDYLPQKLDVDALREGSFVELVNISPIDGMVITLSLAKVENLDGFGAVGGGLAGKWIQEIVATQLHKFLANARPFEPFSNVGQGVGDLIVLPYEAFRNGEDIRRALSSGIKSLAETFAFETLTTTSRLTQYAANRMAGTVRGRRRVNVASNPLPSRPSHAPRGVSDVTGHAMESLARGFQAANYKVIIVPYREYVRNGATGAATSVIKGVPVLLVAPLTGATEALSYTLLGARNALRPDIRKEEEAIRHGITGYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FID0</accession>
    <name>A0AAD2FID0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS7335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FID0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1941065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="86" mass="9664" checksum="53506FA1F434FD6A" modified="2024-05-29" version="1">MAIMGQDVSEEAMGLSELFDADTDKKDILSVQSDLAELYKHLSAVKVEMSLLDDGISASAKALKIRRRTLLDDHADTKRRMEQHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIU3</accession>
    <name>A0AAD2FIU3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS7811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIU3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="397" mass="42175" checksum="5CA239A997D49AD9" modified="2024-05-29" version="1">MNHQSTDEDAAFAFASPMFTSSSGESLFLSRSSVGGSSTTSLNTTATDDFMSTVENVEDLVAFDEDTISARAQRFSIPEIEEEENDRKMSPITVESKAPPSLTIETEMPSATIEATEPAATPTPVIAPNEAGSETELDEEENNMEMSSPAIEPKASPLIIEAKMPPTSIEATKSEPPTPVIALSDVPSETHLNREESNKKMSPTMIEAKAPPMTIEAKMPSTIVEATKTPVISPSDPDSERELGETKNDFWERSLAETEAPSPLMPPPTEEVTSTTTSAESNPDAAANVYKGAKGVWAWGKSVPVFSPLMGIAECVAGKALQVAGTNLQDLDSNLIEPQLQNLDSGILNPAIKTVAGIMLGAAGKAEGVVKPIIVIVLSPFKMLTQQPSNEEVEVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ08</accession>
    <name>A0AAD2FJ08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS4320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000435">
        <property type="protein sequence ID" value="CAJ1934983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJ08"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042034157" description="VWFD domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="4">
        <location>
            <begin position="782"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="557"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="658"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="718"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1934983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1041" mass="108129" checksum="8527A21CBD7205B8" modified="2024-05-29" version="1">MFVQALALSLLALATPGVDAGKPVKGKTVKANLGLCSAQAECIDFTIKKRDSSRCKPDGNCPVEVCMILDTTKDGCMKEGPISHLCAASDGDGCAAFEEDGITPLTGKGNSTDCTLTGADESAAFDGKCEPTDDQTRIVMCQEGEAGETLFWALKDSSVEDFASYDFTGGFTFDKDSTTCSPTIECTGDSGFQCADPSNGMFEKTRVWKYTIPANDGGACDLCAPPPEEEKEPVTAEGGKNNLALCSAQKDCIDFTINKRESPSCNLSGNCGIEVCLILDTTKDGCAKEGPISHLCAASDAHGCAAYAADGTPMTGKGSSSDCNLTGLDGASAFDGKCEPSEQQTKIVMCQEGEPGETLHWGLKDSSVTDLGSYDYTGDFTFDNDSTTCSPVIECTGDSGLQCADPKNGMYDATRVWKYTIPTNDSSACDLCGSSGTSDTNVVDSATSDGDSGSVGSSGADSETAADSGTNDGDANSDVDSESSGSSGSNSGVDSDTGNVDVTSSDYPDPISTNDGDAASSDVDSESIGSYGDVDSQSIGASSDDSETNADSDTSDADASSTDGNSADIAVAPTATADPPTTDTTDGDVTNSDGDSESTASADSNSGTNADSDTSDADASSADGDSADIVVAPTATADPPTTDTTDGDVTNSDGDSESTASADSNSGTNADSDTSDADASSADGDSADIVVAPTATADPPTTDTTDGDVTNSDGDSESTASADSNSGTNADSDTSDADASSADGDSADIAVAPTATADPPTTVNPPTAVLPPIVPDTDLASYEAGSQGDPHFKTWRNEHYEYHGQCDMVLVKDPNFADGLGLDVQIRTKLVRFWSYIKSAAIRIGNDVFEIEGSVDGPIGEIRYWYNMEFKGPVKTVGGFPLTIRSNGQSKKQVVQIDLGSKYPGSIIEFQIFKEFVKVDFLKPTADAFGNTVGMLGDFRTGKTLARDRATEMHDFRELGNEWQVHPHDMMLFHITEQPQFPTQCLEPEDPRGARRRRLEESSVSLDDAEKACADLTDELDRKDCVYDIIATQDMTMAGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJ20</accession>
    <name>A0AAD2FJ20_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000413">
        <property type="protein sequence ID" value="CAJ1934909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1535" mass="175073" checksum="3089E7D42E6FB3A2" modified="2024-05-29" version="1">MGATPQLLPLSGQTAYPREAFMVDLLRAITQWRDEGCEVIVGVDANEDVFSYQDSSFCQRLRSIGLEEAILQRHPSRTAATQHRNKRGRPIDGIFATSRVVVKAGGYYNFDEFFACDHRGLWMDIDLERTLGSYRPEKTPYKPRKLTMLDTAAVRRYLRLVHQGYDMYSIPLWLEQLHRQLTLNSGIMTEKMGRQYNCLHKQMYDIRRNAEMRCQRVTNGAVPWSPQIQTFWDRQSLWKLLLKGRKQCLVSSRKIRRLMKKTQLPDAWKKTTVELETALRNDRKEYLHAKKIHTVSWRKEFLTVQVKKSKKKQWTSRKARYRFLRLRWMKQREEARRRRCAQSKGSTGGLQAIQVEETLPTGQVDLRTLTDRRQVEQGCMQENRARYDQTRSPYTTPPMDNPLYSMFTGADAERNSHTLLEGRLPMPDGIDSYTKSFLEQCRFHQGHSMIPMEVSPADHTYFWSPNPENKGSEPHGLHNGYFKAGIYSPMVAQCNALFRHIPLTTGFVPDNWRHRLKKMRTIQLMNSESQANYKKLGRLAMAYGEEHHILADGQRGSRKHHQAIDLALSKRLVWDLLILQRRSAGWISNDAKSCFDRVVHWVAVLAMMRLAITWNALRMMFDTLATSTHRVRTGFGDSEESFHPSSMVPFQGCGQGNGAGPPIWVSVSSVIIQMMTAMGFGFECLTAIDSQLITAQCFCFVDDTDVIKAGKSVEQSGEDICHSVQQAASTWAGGISATGGAINPEKSFWWLIDFVWESREGKWRFRRTHQLLLDHPLQIPGLTGELEVLRRLEPDEAEKTLGVMLAPLEDQHAHVVHLKSIAKKWAEQVRSGHLHKYDVIPLIKTTVMKSLEYPMVLTTLDAATWVSIMSPVLQVCLPKAGICRSFPRDMVLAPLKFQGLGIPHLFGTQVSKHIEVLLRHLSNQTKTGAYMEAAVQEHQLKTGTSFGLFQQDYSNTATLASDTWLKRVWKELEDLDIYVALDSPVLPLRCKGDALLIEVFMELEVDQDALKWLNWCRMFLQVCTISDIVTADGLSIRESMWHGERDYAHWSSYQWPRTVRPNRNHWKVWQEHLTRALLVSDGPQRLLRHPLGPWFDLLDNWNWLWSSTHGLFHCKGHGWQHYRNRRSSTRNIQWDYPRSTQLSGCKRPHNEHTDNGVSFLPVPFWTQPLPADLCRATVHITPLLGTLALTDIGTASLQPHHDSQPSLLAAWMAASARVTKYVGWTPEEIEIDGDESLVVAALLEDRLCVISDGSYKLGLGTAAVQLLPRKGGTERIIVRCQTPGLTDDQSAYRSELIGLLAGIMVVDWLLDQWAPTLRSPPRVRIACDGFSALLNTFGDNRVTPQQAQFDLVSSIREALARSRASWEPSHVYGHLDTATSFSCLSWWSKRNVEVDAWAVAYCHQLEASHRLIAPNARFFTKLAALYIGDVKQSRLNPEQVQELVALPALRKRWHERQTITPEAELETDWTSLARAMSSLPAGVQRWTTKHVVGMCGVGKFKVRWGAADSAACPCCGEFEDHLHVPRCTAPSVSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKF2</accession>
    <name>A0AAD2FKF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS5675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000656">
        <property type="protein sequence ID" value="CAJ1937480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKF2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1937480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11865" checksum="2979386324B7F6ED" modified="2024-05-29" version="1">MMVNKKQLTIRFHVDDVLASHMEQRVLEDFFSWINERYGGLKEVTCTRGRVHTYLGMTLDYSKKGKLKIRMDDYVQRMLDEFSVKLKEDDKQETPAGKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKH3</accession>
    <name>A0AAD2FKH3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKH3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1040" mass="115698" checksum="80D5C24EA8C6E296" modified="2024-05-29" version="1">MRPNIAPGYHNSRPSRHSSTAHTRVMMMKPQQMDKNNLTRTRRPQRSNNTTARSSNARPMNQSSSRRANNASRNRSSSSRRGQAPAAAGTTRVTRAKGRETREYYSDYSSDESSSEGYSEPTDCYSSEGDMATLLDDRGVVVNASDLSECWSKVPIESDEESAFQRFAKRVVKKEREQQGFFFPSPQEEVSLPSLETKGHTTFTTYTDAYTQADTYTEADTYTRADTYTEADTYTRADSYTEADSYTEADTYTRADTYTEADTRTSYDRSYSDSDSDSDEDSDDSGMRSTPTYHTTAVQGNMWMCGAGQADDDTLAAESYGGLRQNEVLIASSRTIATFETRDAEGSWRNRDSRASPRELVPQHGRGNSQKQKTQKPKQSLIPEKSTKPQKPQKLPSVARTAKGFAKKVNGPTKLEKIEESQTEGATQSILALPLQWWYGKTQEDEKQERESRKLVEIAKRDLLVKPHLHVDGTRSYDGSLTLDARVRKDAEEGPWSNANPTDIHLDGRVKKVTAPEVLNGKRHQAALERAPTPPTPPSAFAPKKTQKIDVWTDGDTEVESQVPHFSGVCKVEAFGGGARQSNKPSNVVAPVNKDNCHHDTDQVVQSQHQQPTQELSVEQEQEAAAEHERGGRNTLHQEVQDAAFDTVWMAPSAMSRMSFESSQTQPTVNTTTPQSMAKDQALLTDDKGRHERNNSSVSNLINAFENNAVSAVGTPPTIEQNRARADWRSPGGALVAPVFPAPVVPAWLASVPKDHEDKGRHSPEQMMDPEQMMNQQRCLFDTDDERTEMTDDPSTILQLDANGQVSSTSSGYHHHGKAFDSDLLFLGNADPESVQPVAPISSSAKRVRSNKIKELQSETAFSTNKDNDVEYFGQFQRETLQSEEPATAKTSTTTFMKPRRRRNTVKSFLPSFPRRNQKGGGGAPHQESYLQLDDDTNSENNNWGTTTTTTTSSPVASNKVRQDLGNADNNNGMMTHNADHHDYEYKNNHEDHADDYPQDDIVRDAMKSINDTEQALRDADSFFAAGSFYEALDDGFSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FKP5</accession>
    <name>A0AAD2FKP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Acyl-coenzyme A thioesterase THEM4</fullName>
            <ecNumber evidence="19">3.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Thioesterase superfamily member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">CYCCA115_LOCUS10067</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40151"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40152"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:40140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the THEM4/THEM5 thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="19"/>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1945925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FKP5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052365">
        <property type="entry name" value="THEM4/THEM5_acyl-CoA_thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418:SF19">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="28" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="29">
        <location>
            <begin position="166"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="CAJ1945925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="307" mass="33918" checksum="B3BFF7F720747784" modified="2024-05-29" version="1">MTTTSNRNISTSTVRSSFLPFLAGIAFGIASSILYTRVICSRNQKSSSSSSSLWLQPPSTLPRFAQEILSNHHHTNTEKISNDDSNGESTNASSPNTALSSENWTEVRLREWEDLNWRDANGWQGRDLCHNPQGLGVRILHYYYKASSKEMVGVVWFGPHAESHRGLCHGGAMTSLMDDFCGHLAFLHSTSGQPWSGATVQVNVSLKKPVKVGSILRIIGRIDKHEGRKIYVHATLDDGGGDNNGGSSIDGEEQNKDPLVYATLEGLSIDGVKMSQHEDPVSKRTWEVEVCEHSGRLQRRDSGWKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FM75</accession>
    <name>A0AAD2FM75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS9171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001313">
        <property type="protein sequence ID" value="CAJ1945024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FM75"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042255718" description="Helicase-associated domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="84"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="169"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="255"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="324"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="390"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="467"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="540"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="612"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="682"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1945024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="748" mass="91255" checksum="6441153974B05027" modified="2024-05-29" version="1">MKESYSVTKNNKKLVFLLLLQLGLTTAFQPPQQQQQQQILSRHRRRTRYPWSYISAAASGAALVDETNEEVEVEATQISFSSPHAWDEQFEILQSFQKKYGHWNFPQNPPEALEKEYPTLVSFCHHQRVEYKKTKRSTTNHWSTLRLFDRNLRCQHLKELGFEFNAHVAKWYDKYHELLQYRNDNHGRIYVPVPETKGEGEAEQHHGNNNRSLYRWAKVQRARKRRNKAYEELSDTQVELLDRIGFEWESERYDVLWMEKYNELVDFRKKHGHCMVKPGGKLYLWMKEQRSRREQKHYRLFPLSNEQLRLLDKIEFPWKPELRDSRWNAKYKELEEFQKKHGHCQPTKSPDRTLYDWSRVQRKKRETGVLPTHQIQLLDKIDFPWELKRVTFRLMVAKLMTYYHQHGHLRVSQDDEDDDDDSELYEWMALQRKRYHGMVTVSGSPMTDEQIEKMEETNFCWSQDWKERVWHEKYTKVVEFYKEHGHVHVKKKDYPSIYNWIQVQEERYKGTEGYKPLSEEESELLEQIDFAFFENRPRMSWNTMYAEVERYREENDGRFPNHRDDPELSRWMRQQRKRLRSSYGHVPLSDEQASMLKSIDFPMLPKGFDLRSWCERYDELVDFWKHHGHFLVDRFENPRLYKWIAVQRSTHDVAFSYTRPPSRSEKYLLDRIGFPWTSDRYELEWQKIYEELVQFQQETGHLQPKVADYPSLYSWMWYQRERYQNKELSGMPTHQIDQLNKIGFRWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FML7</accession>
    <name>A0AAD2FML7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001557">
        <property type="protein sequence ID" value="CAJ1946061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FML7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="102" mass="11397" checksum="22F772E54E997DEF" modified="2024-05-29" version="1">MRFVISKNTATPTSTSSKQSLIEEREALATVNSSQSNPSRVVIRRSMSSLSERQASELLLDNSDRLSEMIMGKGNITTVYNCDYDNDCDIDYDSDCECDLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP30</accession>
    <name>A0AAD2FP30_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001745">
        <property type="protein sequence ID" value="CAJ1948191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP30"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="95" mass="10791" checksum="8B2C857DDAC10BF2" modified="2024-05-29" version="1">MTWDQRQHRAILEYERDVDLDQQVEKDDNEWIEKLLAAEQASPEFEGTITIDLSMPAAKDMDDRATVGSTIGEHESGYQQPLHRIRDCGGRTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP85</accession>
    <name>A0AAD2FP85_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS11502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001745">
        <property type="protein sequence ID" value="CAJ1948195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP85"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1948195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="137" mass="15565" checksum="31087CE456A91F11" modified="2024-05-29" version="1">MAPTPKGTAKHCSGVSMKVRQWILTWCHSWTIADGRRAWKTNHWKWIWRTMLASGVRWGNTKVQSHTACIMAISKGEWHPTCSPAATRSFAPSFLPQDLSQPSGATCLIEKKPGEIRVDLMCMIQMMNLELQANNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPA2</accession>
    <name>A0AAD2FPA2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001740">
        <property type="protein sequence ID" value="CAJ1948098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPA2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="892" mass="98798" checksum="1C38EC5A01C78A37" modified="2024-05-29" version="1">MGKSKNNKKVAIAAKAVTSSALTQGHISFLQKSRVETAKIRSKKESDNLDPPIANNNNDIDMEEVKHPLQYDRIVPNIDLSQWNLQTLAHLCTIHRYSENFVDPPATESWEEASEKLLQICDGDWNLVEQRIRAAHDRDIKDEFIGNDRELVVYVRGLILGLAVQDPLVIFPLDDPMEETTFFNRYWDFTLEVEPRLLLELRPLAKVWAIEVELLGHLWTDPDTTTVVTELAERRSAAKGRKRERNLDPSMERKSAPIDPRSPARGFFPDATPKPVRDSVAPNKDDSVMMDTTGPSVISPTNKPVNGKFAYCSDNDGSESIESAPDFSAPSNSDQPPTEVVVGKSPAPAQRANDPSTTVLFDSHLSKTEPPEPPRPSAPLSVKKQLTYVAASQKKTAIRTKYFSEEMKAREVTQMNLTGLPRSNAQFLCATINYEWNGDTSEGGSIEKCFTEEMVSVLSMAMDNAEGDLVILPVSELRVRDKKLWLTSKEKVEELTYKKLKPYIDWSWNNGARFGYNAKNPGSKTLRTRIRVAHNSSLDDMSRLLGQCFEITGTHAGVFRSPLQVSDPVRIGWLLNYPMGIGRAALERELMRHFTFKRAIALEPAWPQNPGTAGQKWMPSKGPKAWHIWVAASDVDRVARALFAWLRPETKKCHMPFGARTQFVYDWGAVTKGHLGDLAQPGGQWNGIIGKLINTHDTTSQTCTSLAPLFPIQGMLTKCIPAVKKPLPAQPEQSATQDADTPDSPSPPSVSSTPPDLTPTNSSVTAPTAAQPTLPAPSTKRSSRKRSKNRRAKQPLEKPTETPQATPPTPLPRPTPALKSTPQSATNPPTESSAWAKLSASEQPLVTEAFDRSAWLAAMDAELNQGPAGLFQMILPGPIDGFYVFVVRQKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPE8</accession>
    <name>A0AAD2FPE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001747">
        <property type="protein sequence ID" value="CAJ1948533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPE8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="10868" checksum="00413084075A9DCD" modified="2024-05-29" version="1">MTGSRTKQSSEMDHEAWFLPNGHKNAYPSSSLRGGLSGASMPVSAVTFGGEEANGSSATRKQEQKEQRCRVVRAIVFVAVLLAGAGVGVFFCLKAALTMTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ41</accession>
    <name>A0AAD2FQ41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CYCCA115_LOCUS11962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ41"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ1949173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="578" mass="65115" checksum="975765411DF89846" modified="2024-05-29" version="1">MQNYIVHEEIGKGSFGSVFRATRKKDGKAVAIKKLNQTFGDWNAVRTLRECRANLVLSRDCKYLCQMYDIIRENDGTLYFSMELMPDGTLNDYIQSFRQQLRTSSSGDSNSARTHIGPSSIQSILRQVLRGLEHIHAKGYMHRDLKPENILMRGKECKVTDFSLSRMTVQKSQILQRSHASQECHQQRHGTRHNSPSQPQHHHCNPMAPTHTMHNALHQPSKMTSYVSTRWYRAPEIILCAPQYSTAVDLFALGCVMAELYTLDPLFPGSGEIPQLALICELWGGPLHWHEHWPEGKRLAAKMGLEVVADHHHLHHQNDSHQGGRNPTENEVQVRHHSVESTCRSKLRVKVPSACERALALMEHCLRINPNGRPTASNALQYDFFDPLVKNCPPSSISASPIPVDANTGTKNHHHHQNDNDSIAFLYSRNTPPTTSAEFTNHLSPSLLLDQNSQIINQSAAAVVSTNRDVDQGVFSSAMQSSSSHGSVMGFLSPSNISNTDLNRNSGLLDKHSLLGSIDCKKRRSQQSIIHSNRKKRGKEYKPSRAFFADMSNPSSLPNTMDWQPLRSLNFADVQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQH0</accession>
    <name>A0AAD2FQH0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48218">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48218:SF3">
        <property type="entry name" value="OS07G0170800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1949590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="375" mass="42749" checksum="7229D7713C7E71FC" modified="2024-05-29" version="1">MEFELRGKRLLKLSSSEMTDTRPSKRVQNSSEKGSADLSAMPTDVIYNVASFLDAKSLLNMRTLNRSFRVIASHNSAGWDSLCETFWKTKIHIRPEARDCTDRMAAYRLAVEDARTRDHLLPEELIYDVETKTGTIWSFRFKQSAGEDWTESDPWFNGLPCRKMVFLANGRVKMLVQDDDGEPSIEHPRFSQLEPTLADPPLDMAWRFLSRPLDMPTRPEGSYIRFSVGGRDVPTYCVHRSPTKNWGFVMESCWGVYASFELPKKPISPTSRILRRAQDGAGNWFNVEVEVEDGELSECEHDDDDGDNEEEGQNRNRLLIDDDSFAVTSGLQWKEAFLYNFGARTLPEGDDAVAQFERTYGAVLNRMNVTADIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQK8</accession>
    <name>A0AAD2FQK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS12166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF75">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT 5 OF PYRUVATE DEHYDROGENASE COMPLEX, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042067599" description="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex" evidence="5">
        <location>
            <begin position="21"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="44"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="155"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="264"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="396"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="460"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1949576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="745" mass="75900" checksum="65B29518A6D69B7E" modified="2024-05-29" version="1">MARFAVALLCLLAFQYEVSAFGVVKQSPSVNYGSQSSTQLFAEGAKILMPALSSTMKEGKVVSWLKSEGDEIEAGEAIMVVESDKADMDVEAFEDGFIAKIIVGEGEIAPVGEAVALIATSEDDIAAVAAGGVGETAAPAATEEAAPAGGESVETTEIFMPALSSTMSEGKVVEWLKKEGDYVEAGEALMVVESDKADMDVEAFEDGYLAKIVKGEGEMADVGAPVGILVPDEASLAMFVSKPISLSPPVTTGASAAGPPDVEFSQIDMPALSSTMKEGKVVSWLKAEGDPIEAGEAIMVVESDKADMDVEAFDEGFLAAIITEEGDSGAVGAPVALIAANEADIPALKAYAASLSGAPVPAAAAPAGAAAPAAAAAAAPKKVAAAPAVATGDRVVASPMAKKLAEEKGIDISTVAGTGPNGRVTAGDVEAASAGGASAPAKKAAAPAKPAWTPAPGVIAATPMARVAAKKAKLDLSTIQGTGSFGRVTLDDVKMATGEKQPERKKSAATGAPAPELPEGFVPFTGMQKAVSNNMVGTLTVPAFRVSTDIEMTAFEALYQKVKPSGISVSALIAKAVALGIERHPIINSAYSAQDGGGTLFKKDINIAMAVAIDGGLITPTLNYANERPVAELAENWKELVGKAKSGTLSSAEYTSGTFTISNMGMFGVTDFGSLLSEGQGAILAVGGTQDAVVPCSQSILGLKKVRKMTITLTCDHRQIYGADAALFLRTLKNIMENELDKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQQ6</accession>
    <name>A0AAD2FQQ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQQ6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="255" mass="28690" checksum="FDF0BAB81E1F0EB2" modified="2024-05-29" version="1">MRPKEARQYIESFLQQWRPVFGCGDVDDAESSTSDLVLRKNSGNNPRRKTTKKNTQKWLRQVSNKLMEQTKIERNNTDSTSDSHSAEPSIPSTIETSTKIQSLSQANLINDSQINEPIPAAVETTSIGSLTNTDVTGDSQFEETMIRSPVKPTQRACSFENNGLPRSQIQSDEPALATIENTRRVQSLPNASTHNNRPLRRQKRNPEREAFFKVRVYDLGYSGDDDILALSTIGGDTQQADDNKGWPNDFYKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQW9</accession>
    <name>A0AAD2FQW9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS12344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001759">
        <property type="protein sequence ID" value="CAJ1949945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQW9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1949945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="107" mass="11796" checksum="B6AD55E9CA913294" modified="2024-05-29" version="1">MREASHAELRMLVKAHNNIATILEQTSAVDASLKSYERAFEICSGTDDPGNLNGMLEIILRNMFGLLQINGRMDAIDQFASEYTSNEMRQAEIFATPSAAESSTVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FRV7</accession>
    <name>A0AAD2FRV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FRV7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="69"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="529" mass="56454" checksum="E8C3BB66355425BE" modified="2024-05-29" version="1">MFNRKKQRRQAAAGVVQSMIGGNHLPTNNHASAAAAKEASARKSTAQPRPDIVIPPRGIGPIADPNDNDVLCGRGGRINSHVGNRQFREIIASHKKDYLAPTTKKLEKAHIAAAIVNDIRSMQPAGRFLKEDGKSGMWYDIGDAKAIKKTGQALREDAPDIRPEIDGESVVTETAPAATTATTTTTTTASKSPSSSKPTQKSPIVPKMVNGAAASSPSPSPRNCSSSSTRTTSGTAFDAHGPQLLPEGRRNTVDQQGRAAMPPPFHQFNPPQQANNPYLKHYSQGTSGPPQTYSGSFPARSIPIQAPQSVSADYIHEVQQQQALLLPHVEENAFGRPFHPPESAIGSEGTMSSISGLTDPVRSTMSGSGMNGGGTNSTRSPARVTSGFANGNGNNGGSRHYQYAGAHPYAAASAHHHHHHHPYAPRSSSNSGFQPPQQQQQQHHHPAAAAAEYHQQSKHQNSSSNNSFSHARFNDVNSYMQMSLGGETCPWGWIVCGGGGSSIARSPSFPARERFVFQRHGQHGGQHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSI2</accession>
    <name>A0AAD2FSI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="146" mass="16113" checksum="4B34F6394CCB60C9" modified="2024-05-29" version="1">MYRAPIMCLWLNRNESHEAGTASTMTTTTTTPQSSPSSSSATNELIQVLGRDIVISCIGGGLIYWIYHRRRVNQVRRLLGLPPRTSLGDRLTGISSSVVSTALKLGEKVVNLLALAVIIQCRLVPAILVRCAFASKNWYHLTFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSV3</accession>
    <name>A0AAD2FSV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001770">
        <property type="protein sequence ID" value="CAJ1950738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSV3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1950738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="284" mass="32195" checksum="210C236D54A6FF3D" modified="2024-05-29" version="1">MNKNHGFFIPDSEHLTDLEGLLGYCHEKVKLGHFCLYCGRVFPTWQGCQNHMISTRHTKLRYEQGFWEELDPFYDFSREHKNFIGESNNDEKGDAVESNIPKNTAVVDDDDDDNEDWEDVSEHGDDDDDSARDYRGYEKEIARFGLDITPLGELVFPDGRIVGHRALHKYYKQSIRSTAASDAVVAAKTAAGERMYDGRVVNINSPLPPETNGGSGKGILVPMKGGPEAFSALSLYRYRAAVRKQRVDDDKGRRLKYRTTQNMNRMDKKANRLMNGVSVAHAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSZ2</accession>
    <name>A0AAD2FSZ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001807">
        <property type="protein sequence ID" value="CAJ1952601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSZ2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1952601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1121" mass="125694" checksum="2883AEAF55AC28AC" modified="2024-05-29" version="1">MRSPVPTPMFPPNQGFLPGLPNQSTTPVSSRRQFWHQRPRPPTTWQPKPKSEYYCPGKYSLAISSPTRMGVLTFEQSIKALQPTRNAYHALFDWDVHRIQAAGMAAIQGASFTTRSLVMNPSDALSCFSLLQFLPSDRTDKDLASHINKDEEACMQEDMGEHVTKRASKKTKLYSKGRCASISDIKSTISNVAQLAAFATKNFFMSNNTPFMVEQFDTVMVALSRPDAVQWQHVIDLTGVAVHIIHDLQTVFQVIAYEDKDFTLHAEARPLGTIQRAELFSGARAQTQLLLDKIDEGLRNCRHPNYPRTSALSALISSTAAPDASPSGKRSSESPSSKQDTAASPAKKPKPSSEESTTRGMLICTSTGRPPMPDQKWKVNGVEKTACVNFLFRNFQCTNTRCTLLHLHKRVFHSCPVSEQESFKTWVQSTPNVKRAPGQEPLTVAAASVSTLTRQVNYYVSRPTPTSHCVDPQDECALQDYPPTWTIFDELDPADMLVADRFRHILEQGARGTPTFTRLEQSHFLRNLPSRTALAVESPYGKDSNNRCFKTESTFCHTFVFLYKSGYLDTTTGDRLGKAFSGALLLRLLLKSHEFVDFRPLRSVLPSDTPMGQFMHCWSRMFTASLLHYNLDVATAVRYVGNIHTGAHQDWNALEPELRAASVDDGLNAVQKDFARSHSLVGNPLFAPFLPDTQQIPQGLVVVPGKSDRQICDGTFCPLLESIPTNDMTTKDTEHKVEFPKLLRNHLAYIYNAGISYKSEELYLGDDDVSGAFRHGKWNPNVIGMHTFSIFGFLFFCTGLTFGGNTCPSNFEIIALSRMALAHFLWSQVSTISRVLRYLPAISTSPEPTPDEIAQFTPAEADSINKGVFNPDGSRIPPNFDCLYVDVAKTLRQTIASSVLALYLILGFPDASKGIQDCVSWEKFTTTFSHRRHCLGLLIDSRALMVSLPSEKQDHIIQRLRTFLRQHRLTLQEIAELLGLLSNATTVCRHMRCSYFNLQRFLRLILVHRYRTLIGYHRQKDWELQIASRLSSTFIHRMDGILSRKMAKVLWGSKQSYNLSPAAIQEVKVIIHITKNAGILGSYEPEEASVERQERLPCQFAQSSPVDEENSVATSLEEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FT96</accession>
    <name>A0AAD2FT96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FT96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22013" checksum="3D4BF75E0B14DE22" modified="2024-05-29" version="1">MLPHYQYKHYYDQLCDCCEDAMVTLDERQEEGGECGGCEKTMCEDCHEGQQCGRCDVTFCNSCVISCEFCDDELFCGHCLEDHQQNCTTCEKTMCEDCRACDLCDENCCADCVDVCKFCNDEFLCVSCLEDHQQNCTPLTRIIGKLDKLDKSLEHKESEKARLRRRLGEINQDIDGILAQKASAERSLEKLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTD8</accession>
    <name>A0AAD2FTD8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS12991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTD8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="364" mass="42425" checksum="C0E6B667F4A6759D" modified="2024-05-29" version="1">MPAHAHNNRRRRQRRSMGTTLVTTAVVGYGAYRLAEWLWSSDEDDNHHDDPEEEGIFSALGSWMSSTMMRNSWGQQQQQQRYSPSSPQQQPRLDPRTQWKLRRQRVFKCREESIKACQTCWPALTENIEEMTNTSAAMRKLRDLRASKDGHSDDLWKEIYVETLTRFLSCVYAHGLWFSMSTVQIHYVGGRMFRQVPPLEDDEKSMLTESHQYMLQHGLNRLVPMIRKTILPFIDEWKATTTISKIELHQLIRKVQSTIDATFSTQNNNKYARNWIRFVLPDDSVDEVWDICQSPVWDDAHSHLLNDTIDILLSSPEENGEEEIAVAKHMAPLKKSCPKLSLPENYQRWIAMPAMLELGDVSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTP8</accession>
    <name>A0AAD2FTP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS13936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTP8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1953250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="43898" checksum="F0DFEE329EFF0CAD" modified="2024-05-29" version="1">MMATAHRPLGTILMIQSMVVAEAHRRGGLGKHMLTNYLEFVCGESLKQPVLEVAIVAEKEYFNFFLTAGFSIMRPLTLVDGKDQQYLFQKSLELKKIGRECYIVDSFAAEAGTGNPAGVVLLPEDSDEKALSNWMQNVAAEFNLSETAFCWPRAASECSNSELHWNIRFYTPTVEVALCGHATLASAAVLYQILPNSSQSRIVLHALEDLLTTELAKNADNHGLRQRKICMEFPAKPPIEITANKDKNIISNMMKEAFSCQLEPLYVGLSEIGDILVEVTRESFENIGFENLNYSALLEWDGYSRGIIVCSSNDTVDNKEGNFDFLSRFFGPKAGINEDPVTGSAHCALAPYFASKLGKDSVVGKQMSVRGGFVECMVTGESVQLTGTAITTMSGVLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FTW2</accession>
    <name>A0AAD2FTW2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001816">
        <property type="protein sequence ID" value="CAJ1953084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FTW2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="302"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1953084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="90549" checksum="EC699E816BF41F87" modified="2024-05-29" version="1">MAVIKVHTKIKGKLKDRGRTVMFVGYADNSSVDTYKFYDPKTKRISSSRDVSWLNKSYGDWKGIKKTNTLRLTQELLLETANDNDIVQAPTTQANDANTTTQETGPTPTAPTATERATMPAVQLDSGADPQRVTHSATTQQPAKTAPTPRWQRDLQTWDMNRHGTQPILRTRTQTRLATANSESGRETATRVRTTEEPTEEEEIDFTGDQRGPLFNENDVANMMMNPDLQWPDLALQVTEKMMKNIMENKEIEETNYKEPKNFQEAWNHPDKYQRDKWREAIRKEFRDMIRRGVWRKMKRRDLPYGRRCIKCKWVFKIKRNGVFRSRLVACGYSQNPGVDFTEHFAPVINDITWRILLVAMMIWKLDAWLIDMETAFLHGEFDEGEQIFMNLPVGYDLVDSSIDMSEDCIELMKTAYGTVQGARQWWKKFVSILKDIGFEGGEADPCLMHWNSEHGIVFIGLYVDDCLCIGKPEALELVEAKLKEKGLTLKTEKTLKDYLSCDVSFNEDRTKAVLRQPHLLKTLEEDFGEMVRNMPKYKTPGTPGQGLVRSEEGVTVTPEEQKQFRSGTGKLLYLVKHTRPDIANAVRELSKVLDSTTPRAMKEMKRIIKHVLDTKGLGLKIEPVIGSKGLLWNVVAFSDSDYAGDPDSRKSVSGFIVYLCGVPICWRSKAQRTVTLSSAEAEWIALSEVAKEVLFIAQILETMGVKVEYPIVIRVDNTAAIFMATNVTTNQRTRHVDIRTKFVTQYTGPDGILKILFVKGTDNESDIMTKNVTGNLHEKHIPKMMTNVDEGTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUM5</accession>
    <name>A0AAD2FUM5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS14315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUM5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF7">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="29"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1953712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="427" mass="47222" checksum="7B352B472DB67507" modified="2024-05-29" version="1">MPPKKKNQGTDDDLGPMRAARFGRVKNTLTMGFVGLPNVGKSSLTNLLSGSTHAEAANYPFCTIDPNVVQCIVPDKNFKYLVDTWKPPSIVPAALKVTDIAGLIKGASEGAGLGNAFLSHIAAVDGIYHLVRAFNSDEVIHVDDSVDPIRDLETIQGELCAKDASSLQAVYDRECERVRKEKGLSRQATNFKLSEPFTEAYNKVKALVESNTPIRSGEFTATEVDIIRDWAMITTKPQIYVVNLSQKSFVRKGSKWLPKIGEWVKEHGGGQIIPVSCEFEQNYFDLKDDPENQKAFLEQCKEEAIGAGLKGPQAEIRSMVPRLIRAGRQALCLQSYYTAGPKEVRAWTIMKGTLAPQAAGVIHTDFERGFIKAEVCNFTDFKELHKGEASMAKVKEAGKYRQEGKQYVMQEGDIVVFMHNTTTGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUN6</accession>
    <name>A0AAD2FUN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS14192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GmhB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001836">
        <property type="protein sequence ID" value="CAJ1953593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUN6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="D-GLYCERO-BETA-D-MANNO-HEPTOSE-1,7-BISPHOSPHATE 7-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891:SF1">
        <property type="entry name" value="D-GLYCERO-BETA-D-MANNO-HEPTOSE-1,7-BISPHOSPHATE 7-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1953593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="221" mass="23829" checksum="9EF5AF2A24AE7AC3" modified="2024-05-29" version="1">MALLSISIQALARFPVPKLVLLDRDGVINQDVGAPGVISKTQFQLHDGVGTAIAKLKQRGCRVVVITNQSCVGMGLLEPNGLNEIHEEMQRLLQEEDAEATLDEIYFCTAVDDDNPRKKPNPGMVIEACSNWNIDASEAVFVGDTLTDMQAAKAGGVANRILVQTGYGFGLMGNQPAQSPPMIVKANNLVESQSQMSIVTPFADTQDLPAAVQWLLHETDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUV1</accession>
    <name>A0AAD2FUV1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001848">
        <property type="protein sequence ID" value="CAJ1954025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUV1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="188" mass="21242" checksum="30D030E960BC95AD" modified="2024-05-29" version="1">MGYNQFRSDLEAKGRKDMLEDFPIKFNKDSKQETSAGNNLLEAGKGKLLSAEYDQIFHTTVARGLYVSKRACLDIHPTITILASRVREPTESDWKKCVCMVRYLFCTSLYHLTLSTESLRVMNWMIDASFAVHPDFKRHTGGTLSFGGGAAQVMSKKQKLNSRSSTEAELTAVDNVVTMILWTKLFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUX3</accession>
    <name>A0AAD2FUX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS14599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1954001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUX3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF345">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="503"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="605"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1954001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="791" mass="89107" checksum="FB0D77ED47937380" modified="2024-05-29" version="1">MKSAKTADSSDAAETLADAKITQEVKSKRKHLSETADTLGDAKIVHNRKSKSKHSSEAAGTVPVDDAPGADALHSTIPRNISIGTQNSKDRATPLNNIRQLPPTGQPTKKIGLPTKPSSLRLSLVADVAENATKRIGSSLVNSEQQLARVAEQKAKQITDVTTKQIGSAIKQSERVYKKSRWCFWARFIGRFPKYFPRVFYFTFGVLVPLWLLILISAGFGIILADYEAAEERISNHDILASRARTNRISVETIDIGSLPVDCYVQYLNQSNRSLFEERINMYILASSRLEGRDSLNATDGGDTVMTDPSTNVNGTKSTDTDYTPVNETIPSTNNFFNRAFSSTTNIALELGSNSTANHTNRTDNYTFSDLVMETEEDALLYMTQCQKEKTTDIQTYLQLRNAQVSPTDDPMTFNWNRCWSKEMNDIWGPSRFAFFPTPELIEASRPAQQEATLENEFIRILNETEKACLDDGGEENECFELALEEASERAGDICHDNVEGTSWFFFSVMTTIGYGNQVPITDEGRLLIYTGGIACLILYAAVLGSAGYIILAIFDDFVARFWISHFLKYPLVGVGVWGGIWIGWAYGIAVGADNWWQERLPDFEVDRGDSLWFAFVSTSTIGLGDYFLQPEVMFASDALWFSSVFLIGFVFLSTFLNKIGGFLISVLPKRSNSLEHRLKGTNLFFWKHWPCIDYIQSDYLRSLAYDDDSEDTDKTLQHHLQQVQWVETLKSRFADQNLSPPLDDMHVEGETSMDDLLDEEEMILSALLDSVEQRRSEIHVRHRRRRSRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVQ4</accession>
    <name>A0AAD2FVQ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="551"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="677"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="719"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1954414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="836" mass="94188" checksum="4554C3AD82F97DE4" modified="2024-05-29" version="1">MKFRIPKEVFSKLFAETQPKVLKGPNTEKNESKLSLDRKQESDQKAPTMKDSTQNSPKSIDGIIQPKAANDGTYFSPELPNLVITDEDTFDQAMGKCKFQLEQQLMKDELDHPVTVEIFMAMGRLFRKHGRLDGASAMHQKDLEMSLRTMGSDYVYTASACFKMGLVLEEQGELEKALALYQKALDNDPKVPDHELTADICNSMGTVLEKQGQPMRAMGLYKRALDIRLKAFGPDDSRTEETYNKMTNVLHNQGRLGKAVSMSQKAAKREKKGKLKEAMELYQNTLGIRLEILGKNHLDTAKMYASIAVLLEKQGKLEEAITMHGNALDIRLLLRPDHEDTARTYNAMANINHVQGKLDTALALYKNCLNIELKTLGKDHRRTGNTCTKIARILDNQGEKEEALKMYQLAADIQLRTGPDHYVTAVTLSITADLLKDLAKFDEAVATYQKGLDIYLKTVGVEHSDTADTYKNMATILRKQGKLEEAMVHHNKALDIQVKVFGPEHRDLAQAYTKMASIRFDQGQLEEALTLYHKALNIRLATIGPHHLETAKTFSNIAVVLQNQGKLEEATELYRRVLDIRSKALGPNHQVTAMTYTNIASLLQNQGKLEEAMVVHDEVLSIRLQTLGPEHAATAQTYSSMAFIRDSEMESEEALTLYHKALEIRLKTLGKFHPLTANTYKNIANVFHRQNKLDEAMTQYQEALEIRLKALQPDHLDTASTYSEMGFTLSKQGKFEEAMEMCQKALQIQLRVCGSGHEDTAHTYQSISQIFFMQGKLEEATTHGQNALDTFLALFGRDHPYTVEANELMQSIESMSKENSLKQIKVPASRNQYIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYJ7</accession>
    <name>A0AAD2FYJ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001936">
        <property type="protein sequence ID" value="CAJ1957160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYJ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="276" mass="30185" checksum="ED296E68BF72CC39" modified="2024-05-29" version="1">MTITISDKATAKLATTKRSMYSLKAYFDKVENSTIDTIECLIADHWTSPHPTALAKLGPAIENIQSMLDTILKCDNYDANYDEHGDTREDGLLRAIVDAGHIYFAGCSGGFPIECLDPADHLEGWKDLIRSTQSLILGAEKFLSHGENSYHEVALNNLFEAIESAFEKIRGMLQAWINEESDDAHDNRMAASKKIDYDYLVADAKKRAGCKNTVFDDWVAAGLTEPNDGEADTNSNDRKATVGSSSSSSSSPTKKRGAEKATIDGQGPSKRISPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYV6</accession>
    <name>A0AAD2FYV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS16040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="61"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1956033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="368" mass="41672" checksum="4E1E9A700A49E204" modified="2024-05-29" version="1">MTAPSSSATPASPDSTTTVRTAKKVASGLQSKVIQMAEDRSRTTRPIAPPVPIKVIPYEFIGTGALLGTGSFSSGFAIKELFEEPSEGLVMKKLRPEVLRSPVVFAACAADLKMEGNILATMSHPNVVRLEAWSCENMIEEYLRGSYVSSYLILERLDETLEDRMNKWTRKSPAFWHKFSRRKVLMHTMRQHEKCIHIWRLAQALEHIHSYRVLHRDLKPANIGFDSKGTLKLFDFDLARVLPDLDEGDPDKAYQLTALVGSRRYMAAEVNHGQPYNLKADIWSFGVLAYQMLTNIKPNGGIDRDYSKTNKMIPSDWSEELRSVISRCCRQNPLERPSSERIQKQLEQQYGSQLLVKNLSDQEEGPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZU3</accession>
    <name>A0AAD2FZU3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS16967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZU3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1957969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="338" mass="37393" checksum="F8736E30F38B8C59" modified="2024-05-29" version="1">MPTRGLQILATVLNCRGTVWLAVLPFCLVNCAILWAVELVDISFPASGHGLMTLIISFLVVSKVSWSYDRYMKARHGLGQAFCSLRELNQTCLGYTLGLDQDAMRWREEATSKMIALIDCTVDTLKDQETATYLARNVTLNPNTPKYDPMNHVQALRLHLYKGSIFAFHGKLHLIERIRLVDLLNNYVANYKVLLALASTPIPFPLIQMARTFLFLYTFTIPFMMRGVAEDILLAILFVFFLTYGFIGLEIVATKLMFPFGDGSHGLGITGLRDAVIRGITSDIALVGESTAFLGNNNHHKGGSSIDFDASLYAGMGMDDVETVGTDEAGSSIYIPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G0H7</accession>
    <name>A0AAD2G0H7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001958">
        <property type="protein sequence ID" value="CAJ1957941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G0H7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042255721" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1957941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37823" checksum="CFC6CCFDB29B0883" modified="2024-05-29" version="1">MLYTGRSLLALLFFSLTGHCALVAAKITKDEQKAFDRLVKAVIKEGGYVHPSIGILSPAPSGAPRGIGMVENVKPKIESGKDMLMKVPYSYQMTRDLAMSTLMDVIPPMVLVDAPLLELDDSALLVLLLAHEYGLGKNSKFHAYTEFLPSWQDEGGGCGYENVQDFRQLPAGIEPEEIEMALQYATHVSLGMYGDYGEYLANDAWPREWKDEPALALRWAMCVVSSRATAANRRAGDNNSGTGVRLIPLVDLANHRKASSGFVELSGSERIVYDDFMDATSDDTGSFVVRSAWKCGTTRVDLEKGDEITVNYNLPAYQAVDWFLSLGFLPAELSSNTMKTNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4L0</accession>
    <name>A0AAD2G4L0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1962141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4L0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="519" mass="58889" checksum="7EF8D4FAD47A41E5" modified="2024-05-29" version="1">MLPKSILSPLLGLVLTGMALVNLFQDFLQVQQNHWDDSSLLNGSAAVGFVSTATNPTRNNDLLSVVSDRITTTTTTTTTMLSFKDESRLGNGTKMSMYKTNYTFDRQDDAAMHLESTFDGFHDFLVDGPRRRPFSSGLAVTAELLMRQANSGSTSKNYDDGVSFFQSKGAYYAAAWLSTTETFLSNTKLDLQANRKKSERGWNMEAGTWVGIKGRKNHRTNDMLDFFVHHLSRYKGPYSVRGPDQESNWEMYLEGLDAMQYTYEERPFNNPSMDRNGRILVMCPYHGTSDNHSGQDEKRLHLNVTIKALARVFPNIVVTVCDDVNLNYVASESGLNEYLYDVLLVKNLSMAPILKCTHLPFLSNVQVRRLLQKGYYSTDQFDWIYYTESDQPPHLTSLNALLKETLYKNRTVVVPHRSHPIALPRDLNVSMASKQTKRFLEINSAKVLHRVDDLREYSCCFLGKNKTAWEAPDVELFQQYNGHAQVTGECNPFQLTCNICKFRNRTKAGPCRRGPNSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5P2</accession>
    <name>A0AAD2G5P2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS20271</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002158">
        <property type="protein sequence ID" value="CAJ1963677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5P2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130">
        <property type="entry name" value="CYTOCHROME B561 AND DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130:SF171">
        <property type="entry name" value="OS01G0895300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042149932" description="Cytochrome b561 domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="11">
        <location>
            <begin position="44"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="160"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1963677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="41610" checksum="0FDAF08EA2C9FE78" modified="2024-05-29" version="1">MYPRVTNLMMLGWLVIAAAPFAAPTNPPGADSSILELTGGLKGSTLAYLFTFDDPNTGGKDSITVTYTTPVTGWVSVGTSETGLMIGSDAVIGIPDTGEVKKYSLTSLALSDVKPMPDDKQTLVNAAITQANGFTTLTYTKILVEDGEIPINRVGENIFIAAHGPSSTLGYHSARGSFSLSGKVIERDDSLWVVHGWLAAIAWGVMCPLAILAGLFRKYIPGQGTWYQIHRILQTLVIVLTIASVAVAIAALNKETPASLSANHFSSDFSDGHRLIGLLVLIFGIGQAANGSIRPHLPSKPEPDDDEEGNQSTPPPAGEKSVARKLWEVLHRLLGVGLLALAWYQVDLGIVWYHEIFNNGDSESTLNAFYGVIGVLGALIVIGVAMRVLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5V5</accession>
    <name>A0AAD2G5V5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS19728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002109">
        <property type="protein sequence ID" value="CAJ1962524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5V5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042131211" description="Copper transporter" evidence="3">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1962524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36292" checksum="0CC4A00B26C92151" modified="2024-05-29" version="1">MSSTKLFIMLPVMLAARKLDGEDPKVVNLLRLAYGGIQACCVLLVLFTYIRSTAAAQKAQGTIYVPPPPQPFADPNGKKKYTEVKYGTHLVSTARSLLGSTLFGICMTVGLHLYKGMVVGLAIQTIMGPINLLENPLVKALVFGNGLRREDKIFSEKAAAELTDADEIVDESGNPVPRQTREGRVSASFEDLLLDTWDAGNKADVGKLLAAVNKQNCNFKTSESSWTPLMVLSGLNASGVRDAIRQLIEIGADPRIVDGEGWNSLHWAAFHGSVEAARELVKDESLISVKDKDGKVPLEMAKSEGNTDVAKFLEASRNTETTGTNETSTGLRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6S1</accession>
    <name>A0AAD2G6S1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6S1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="1">
        <location>
            <begin position="370"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="459" mass="51983" checksum="7D1F0FAF4819AACB" modified="2024-05-29" version="1">MNCLPKDMIEESASVVLPDKHFLNNLEENADEGGQMMHRDGGKVANVFSKQMPPNASDPKFVDSLIASQMAKLSVADREKAYMDVHGIPDLVEETPELVQKSLLLLQNEIDLLSAKEAYNIAERLDPDYVRDRDFCLAFLRCEKFDCQKAALRIIRHFQTKLDLFGEDKLAMDIAQDDLDMDDMDALYSASGRFLNAYDSGGRVINFITGVPKVYESRAFYNIMVAFRHNAEVQRRGAVTVGWNAGGVKGTSWDNADLNWKLPKLHEATPMRTSAAHGCYTDEDWKEKLAVITMGFNKQVQVRVRIHYGTVQECLQHLRRHGIDPACIPVNEKGQSTDHLEYCLRLEQQRKHERLNYPLRHSIGVPFPQDVLLGKGTPFQNHPGNSNLRQVVSDRYKEYEKAQKGLKKVIAKEIVDAIRGNGGLFLKQDGKKWIPVNGEVAVLKVSAAFRTLRRKGWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7I4</accession>
    <name>A0AAD2G7I4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002109">
        <property type="protein sequence ID" value="CAJ1962518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7I4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="358" mass="40018" checksum="9A4DAA98ACFCEF5A" modified="2024-05-29" version="1">MGGESNCLQVAQQIPFSFFNLGLVNDAKVSQEDLYFSRDDLTNPALQNETPLVQFWLMCASIFDHPWTMLFDEFLEESPIPCIQETKRKVIEGFPNNETNKVEIHKGVKKIFDPDYEDSEEEDDPTGDKDTGLVNKFGQPDGWDSDETVDYNSNDRRKDMDIDVDFGDDGCYDDDNDKDDVEEDDNDADKSSKDSVILVESTYQTTDKDSDNDNNNMGLNTNEAVSELTGVTGEDKDPKLASPPRKKGRSHRVSLVAHSTEMEVDGSSFSESGAKRTHSASTSQPTKKPAQKTDTTSTKKSSKAKHRLQRSLTLEERLDGLRQVNLDGMDGRPLLVELGMAYNYQGQQGGTRPMPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7J0</accession>
    <name>A0AAD2G7J0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7J0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="582" mass="66687" checksum="0F9A404AA92A7A0B" modified="2024-05-29" version="1">MLLTFLLIMQANDVIDLLLNFTAMEFVTNLDGIAFKLAENGYLWSAGEDTARAVTNTRFEKTSKRRVLKRWPHVFMAFVLYSLFVLVVYRQTNRVYGDNIVYIQFTDAIVPWLGTLSGSYVGTRKQAIRNLFGKNADVGIIVYEKKDQKEYCQDSGIPDCKRAFFFYCMKVKEWRFDLVGSTTDLNCDNWILRGSNDEPKLGDKYDILSHSSANWFAQDPKAEKKKALRDEVAVIKSFKAADYKEQELATLEATGVLFDAPYYKIVEDGSRVHDRPVYETFDLEFLAFNGYRWLLVRYDETECAQNCTRRRDDCFHFCLSTFDPFYSRYNASLISHPMELQTSGDTWVPSEELMWFPVTGEGNATQPDLEVKALPVLVSETIDIFENPEGLKDLSVEAAAKRLFAESSRLNKPTSEMPCEAGETSLVIELRTDLWPEETKMLVMEMKELMASFDAYNYREEEPDVAKLNFARAIFKNNTIPNDPLELAGHRSTFSLDDSSKTNVWGFYGGRKDKITTYRYGTCLPSTSCVGVLLHDKFSDDIALPGKFELYLDSKRVDLNKRTTQYCMYELGPSCATTVDCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7P4</accession>
    <name>A0AAD2G7P4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002114">
        <property type="protein sequence ID" value="CAJ1962735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7P4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="83609" checksum="CC0E145804ADEFA9" modified="2024-05-29" version="1">MSKDASLAKRKSRIFPKSLQAFACCLLLAFVIDVRGWVIIPQLICDDKVGIEFPNALKRRQLRADDSSATITVFVSNADSYNAKKLKQDLRRSALVTTIVDLDANPPSSLPNFALPYCKKAQSRYMELHTTYPYLAVELIKYCALAQNDGGLIIDADSPILTTLEDLLGEGLHNNVALLNDEYAPQAIHGAFLYLKDGTIAKQMVNLLTKTTLEELKASHILLITKGLYDSIAADTKVSALTSGIMSSDWYLFQHKCTINPVRGGQIADSVVLSYNISNSYSLNQNCPEGNGFCCSIIDPKTESTVMITKHLIFPHQTPPHSKSLAKPLHAETGSYKEDDLPYISTISEKLLQRPQQTLITPNFFDILLQNDCLPNDKRCMDCMKNRMGGNCRACKSFCQCYCKALCRTPIPQKFISKELSIRPPQYARDPSRLIPKIVHQTWLEDVTPEDYPNMSRLIESFKQSGWTYVFYTDRDIENFLSTHFPLEVRQAYDALRPGSFKADLFRYCVLLIYGGVYADMDILLETNLDLAIESDIGFMVPEDEPADSVGQHKMCLWNGLIASAPGHLFMAKAIESVVNNVRNRFTIVDIDATFCPKPELSILREVDTLFLTGPCLLGAMVNKVLGRHGQASFKAGELDLLEVRKEISLAKKQNVGVQKIDSQRFPGRTIILDQGKRDMGAHRFTFLEKNLVVAATDLPGSDDRGGQKKPAKHYSNTHVDIGIYGLERLYTDNVRANEEIRFAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G813</accession>
    <name>A0AAD2G813_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002206">
        <property type="protein sequence ID" value="CAJ1965614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G813"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="61333" checksum="59970BDC239D1208" modified="2024-05-29" version="1">MHNLAFQQVGNTNKGEYDADEALVVARVIQQLRDGVNGGIDGQDGVSFIQQYYLNKGLKIFKERGKDAAMKELDQLIKRSCWTPISIEKLKPPERKKAVDAMMLLAEKNDGVTIKGLCLFKGNETRDWLSREDTASPTALHEAIICTGVIDAHEVIKNGQRVIYVVILGAIYGMLQASLLWYQNLRASLEEYGFVFNVYDPCIANMMVNEKQLTIRFHVDDVLASHMQHEVLKDFFTWINERYGGLKEGTCTRGRVTLDYSKKGKLKIRMDDHVQRMLDKFSVKFKEDDKQETPAGNNLLEVGKGKLLDKDQQTEFHRFVAKHLFSTKRARLDMHPTVAILTSRVQNPNQSDWHRPVRLMRYMHSTKKGHLTLSADNLRVMKWFVDASFAVHPDFKSHTGGVMTMGGGAMQAMSKKQKLNSRSSTHAELIRVDDAITQVLWTRMFMEEQGYPIEKNILYQDNLSSILLKKNGRSSAGKRSRALNIRYFFVTDQVVKGNPTIEHMPTDDMWGDYMTKPLQGEKFRKFRALIQGDQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G929</accession>
    <name>A0AAD2G929_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS22079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G929"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1966496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="293" mass="32617" checksum="BD36F73120E6B75F" modified="2024-05-29" version="1">MSNIFQPFSSSPLHRSLYDQDFIDAGCNATQLGASFQFVQLTQVDDTVGTWATNYAILALGVLGAFVFGCMKDPLIKYRRFAFSSSYFGFSGLGYGVAAVNHQIRQLETEPKFYWAAYILTTIGVMALQLQIGMNFKASNNPRHWYSLLVCLVGFAVILVIAVWGIQLVAGGYLVVSYLWFVLYFAVIKDWMASLGSIVCIAGFVVQFLFDPTCGTEAYPDCFQDCFLPDPSTFNHNGLFHVLLILGMFLQLFARFVPIIEQQQQEEVQESEGVRQDSKVSIDGGEVEPNNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GA23</accession>
    <name>A0AAD2GA23_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma-70 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS22144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002302">
        <property type="protein sequence ID" value="CAJ1966560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GA23"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06171">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.601.10">
        <property type="entry name" value="RNA Polymerase Primary Sigma Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050239">
        <property type="entry name" value="Sigma-70_RNA_pol_init_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30603">
        <property type="entry name" value="RNA POLYMERASE SIGMA FACTOR RPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30603:SF47">
        <property type="entry name" value="RNA POLYMERASE SIGMA FACTOR SIGD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="Sigma2 domain of RNA polymerase sigma factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="Sigma3 and sigma4 domains of RNA polymerase sigma factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA polymerase sigma-70" evidence="7">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1966560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="433" mass="48971" checksum="27B75451EE2DB3BE" modified="2024-05-29" version="1">MITRTGFVLALLSSSGHSFTKLPQPARLNSISLSSSTFDVETASSPSGRIAGERFSPSPEDINAMEAAFDKSKGKGNGSERLSSIEKEFPNKRKIKASVRETGTDSMKEYMKSMCNHELLNKNEEIILAREIQILLKWEEERDELENQLLRPPTYAEWAATIRTDMSVQELKKQIRRSLRAKSALTESNIRLVVSIAKRYPNTNLSFQDLTQEGILGLTKACEKFDPEKGFRFSTYATWWIKQSIMRAIADQGRTIRLPVHIHDQLNSLRKAERELKLELGRDATNEELIAQTGHTADKIEFLNRVSQHAISMETQLTSSKTKGSGAGIGGSDNSLTLGDLMSDPEQKPVDQASYQMLKDDISRLICTLNSREQAVIRMRFGLDDGKAKTLEEIGNRFSVTRERIRQIEARALHKLRQPYRNHAVKCYVQDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBH8</accession>
    <name>A0AAD2GBH8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS23323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBH8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1968615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="699" mass="79136" checksum="1F31C4F849348470" modified="2024-05-29" version="1">MNGGTTLNINARKDGKLDPELAKKIDRWLISFRRLDPRYKILKFFNQVASEGADDFVDDDTGDEGITDWELGGGEEEMPDKRESVLVRLKKKIGNLFDKSSILTVWRPCSNDAMRKMMEGTGVGKGLDIKGKSAKKGILSAFVPFLQISEEMDKAKIMPIAYSSRLRVYYHSEAARKEVVKRMRNFAKFHEDSEDLDLASASDQIEEMEMLDKFAPESYGIELGMRLFWTAVVVAQNITRTDDSTDGTATGRASSPGFQDANNDTLKKATKAAASNPNSSAPIPVLLQYDKEKAMRPQTLLIAYEENGNVIPVVSDFDCFLLGWRREALWFGCNLPREQEDLMMWEVDKIEEVLSDCHMSPDPWTIRWLDIKKDAHQAGINFDSPPYGYGDPKSYGIMEKAASRMKDTGAVRHGSECFNYGFPQEIDEDFLLVSDTLDGVPWRYLDVEQLQSLLIEKLQEGFVFPLNPKWILCDPGWKDVYDTLMQSDALYADTCRDVWYPTSLGIRQRIETICQKHPRGFQRASGKVSFIASKGYSPLRQALDGGAEMSGNAYFELAELELENYYSRKNTLSRQIALATEPDESEEKDDDKASASRAKRLELYRRDKKELVKMRKEAEDIIELKNSGHISEVIDREVTAGRMPGIQSERPAAKPRSSNLKGRQPNHSTRSPNRPSKSPLGRGKAKLLGFLRTHKEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GCL7</accession>
    <name>A0AAD2GCL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS23842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Deltex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GCL7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="618"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1969694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="819" mass="88350" checksum="620F7E1591CDC106" modified="2024-05-29" version="1">MIMSSNQAESIVIDSDDDCKPAAVPSPRRKKRRHQSSSKEIQGSLPKNKPSATGFGAGDDSDDSLVAYFKGDDKDLISKRAAAKITQEHPQNASTSTIAVARKTRKKPSPTALDSDDDSDIGLVAYLKGEEKEPKALATIKEKVIEIDSDNDCKPAALPGTYPGRKRHRSGVDDDDGDDSKRQQINQDVIVVDTRIITSTKSANNQDIIVMLDSDSGDDEECWVLPPSQQRNRTQALPSSSAKRKSSDFQLATILQQQEYEANSRKNKADAKKEHEAMTKSPYGKAILVVQKILELTKKTKDQYPNFAQNVDSVSTDDMVFLAKNLLETQASFLATGSSSVFVDVGYHYTNSINLDSIRTNGLMTKNERDSQGVKANRFNGSAYGDGVYTGNNPIQFSNYGDTGLIVGRLLGTMQLFGHTSDGVNTVLVPNYKMVVLKTSAQCLPVIKYNKTLATSEQGKQVIQALHTSLQQILDQVFNRGLTAPPMSFDTGAAANNGNRGTMTVPPPASLPIHPSLRNAQKNSSSSSNAPFGGIPPITQPFGAAVGRAFGMGSASTTIPGFATTHGFGGNRGRINQQNGTMPQAVLRYIAPERLSGAVNPTEAFCLPPPSCDFQSDCAICQDALSDPRSCVALKVCSHVFHKDCIEQACKFGSKCPTCRKCLGTPSGKSPSGSMSINVPPITDNLKCSGFATWDTIVIVYSMQAGTQKHYHENPGQPHPGKHETAYLPNNAGGRNLLKRLKFAFLHGLTFTIGTSMTTGATNQCTWSSIHHKTSPNRGVHGFPDPNYFANCNGELDSANVPATNLLDVNGQKLVTTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDV7</accession>
    <name>A0AAD2GDV7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDV7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1969084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="479" mass="53636" checksum="416B21FE23F24C97" modified="2024-05-29" version="1">MSTFSFRFLLPATNDPYAWGTILASCSTAAIAIYYYNSCQHTKKQSSVDDELVVKLLSIEQVLAMGGGGDNAMSTLTWFKMTDSGDNLDKTKQILQDRFHQIIKANPWMIGRILKRNGEHSLVYPKQLWDDTKDGSMSEYFGCLHNDDGSVGISPGTPYDQLGSRLSHLMLKNGPNEALCRVTILPSRSDKRQYFAVVFTMSHVIADGATFFKMNNMLLNVQEDIVSLDPQRIMSTEQQQIQVMGGEPEYKILQSGGFIANMVLGVFTTLLKPSKKASARFYLVNQDGMKDEKEKHQYDTTSTPKKQFVSTNDVLSSWFFQNSTCKHGLMALNWRGRLPGHTDMLAGNYENVLFYRPCDSKTPDLIRKSLTEKKNQGQVLQYRRQVTHDEPMPGFWGMASGSIALATNWASFSKLSSIPGWQEEIQIPLYDTSKLLPSTLAIMLIFRAGPHGTGIMVAGSPEKLANLENTVPFLSKEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHE1</accession>
    <name>A0AAD2JHE1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010292">
        <property type="entry name" value="Uncharacterised_CreA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37952">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37952:SF2">
        <property type="entry name" value="PROTEIN CREA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05981">
        <property type="entry name" value="CreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041935403" evidence="1">
        <location>
            <begin position="26"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1949011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="239" mass="25407" checksum="D69F44B65FBDF2A3" modified="2024-05-29" version="1">MNYSSSMLAIVLLLMLSSTTIQVQSFSLGNLPPHHSSSAVSTDSALGAASNSWMPNGEAVGKVMASGLLAASLIFGASSSPAFAESSKVVGELKGSGLVFKDTLQIERFEDPKVKGVTLYISTFQRPITEKLNKGFFNDPSTASVACAKTGKVSIADNINKSISGEEVFKESRSLLFKNLRVERIFDTDTNTVVYVSFNTRLDKNDDNNKSRFASSLCAVNLDEPVVAAAPASPPPATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHE7</accession>
    <name>A0AAD2JHE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHE7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="376" mass="41317" checksum="0B6069D11B8D735B" modified="2024-05-29" version="1">MHRARRQSHRATTRSRVHGSTSFVRGPPRVLFERGSRAHQCNGIYYSLVDDKCLEYRSETKQGKNRIARSIYFYITRTLNGEFFTRAKGEEEWQPVLENRAVFKIKSALKDKALKMVRDATAQANIIDSDEVADINNQVGHGNGLGMAPAPVIVQPTPANTGAFEPLFDFDNSGQPTAANTDDEIFDHVAGLIHPPQDLHNVETYHTFPENFDYVAGLIHPPQDLQNVQYSAEANISDAVPLVGEDHTEAVNEIFGRRSGLVHPPQDLENLALPVAANIGDAVPLVVGENLTEVVTEIFDRLAGFVHPPQGVENLAYRAAASIGDAVPEPLVGENLTQVFTQNFDRVPSVLVSPTGTNEPIPRADIFGNDALFLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JHP7</accession>
    <name>A0AAD2JHP7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hexosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JHP7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042280563" description="Hexosyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1951912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="45611" checksum="404CCA1534F910AF" modified="2024-05-29" version="1">MARPNSRSILLALFFIFLAVRYLRETGQNPYKTPVFNNSLLNRENEYRDQFNVQNNTKCLPVDEEKPEVEVEERCALCFFGLPRSYESMVLPGLVKNVFTPNADNKCDVFLHYFHKEEEPAQRKNAGGKLNPDEIFLVENAAKSVLGSNTTVVIVNDTDDSFLEQRKYQLERYQETRDKNGIKVYFPFKTKFRISSLDNMVKQWHSIDKTFTMMEDYMNKHNINYTRVAMLRNDVMFLTPFNIAMVDNTEKAPDSKHFVLPGFANFPVTDRMIYGVYDAVKMWSTTRFDRIEKRAWEYKHTGVAMHSEKFMAADLLPSIETAGYTRLRNNNVCFVRTRAASIALWQDCVRDVPKGLEGKNMTALIEEILERKCEKVEGDSAFCPPEFNSSVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIS4</accession>
    <name>A0AAD2JIS4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS14974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIS4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041966365" evidence="2">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1954382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="88" mass="9363" checksum="855DF5F3002E5F46" modified="2024-05-29" version="1">MNTRKIFLIAFLVVAMLSSMAEADGIMDKINSAINSAKATVEEKMGKSNKMADKAAEAADKIKETAAEAAEAIEDAAKKATEETPEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJB3</accession>
    <name>A0AAD2JJB3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJB3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1955697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="148" mass="16133" checksum="85BDD2EF8DFBF153" modified="2024-05-29" version="1">MSNYKTACASDLETEVHTYENVVYLSLGVTLICMVVRRAKAEGFKENPAQGAKVLFSFAGIKVILGIVLLITFPGCPETCGNLCNDDSNSSAHHYIYPIVVFVIALLWFHIGSKYRKLAANGAAFMGEGDRMMGVEATSPTTNMKEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJV6</accession>
    <name>A0AAD2JJV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS16315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001918">
        <property type="protein sequence ID" value="CAJ1956608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJV6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="783"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="834"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="698"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="841"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1956608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="908" mass="102077" checksum="67327AF40451C252" modified="2024-05-29" version="1">MMKISGGIFKNPLRNNRKSEANTSDKQAKATQETLEPTLSEDEDDELSIASFSLRPCTNSTRGNTNRGNIPLNVDDDESSSDSFLNDDPVATKEQSRSSSSERKEEFPKTTVFQYIRRMEKVESSRTFRTVATVEEDAEAEDDEIHASDHYRASFRDFEKEAPTIGPNKSNTSSLSKSPKSRKLKTTKKLETNGFPLDSPGKLKKKKKKNISKKANKDAISNGASFSVNLPESFRDLDEESNRKVKTKSKKKTRKSQNSVDSKSQPKRRSSVESNNKPKRHSSVGSKTQPKRQSSISSVQSKTQPKRQSNIGSTIQPKRFSSVPKRKSSIGSKTLPKRQSSVGSKSMSSDQLSISYIPCSSSGSRDSESQSQEVRISMTEAHDSNNASVSSSSHTRDSQEPKKRISFPSDEAPDSNNASVPSSNPTTESQEPKKSILVPSDEACDMNTPSNSPSASSGNDMAESHGTSQQPSTAIDPPEANALHYSLDLQNPTTTPDAPNEPEHEEDNMLREIIPSPTLAERRKRKQATLDKLVNKFNSYESKLEEERMELSNHSRSLHFKQDPTDRLLEEEIQQKVELQKMLQEETKQKEEFQRLLKEETKQKEEFEQLLKEETKQKAELQSQLQAQLDNANVEGRELEELKEKILKLEERNDHLQQENAQHEESIYSLRLAEKDMKRKLLLGAKSQGELLLLRSTLNSKTAMIEDLSKELARAKQELDDALNQDTKVSPLQKQIETLEANKRNFAAEVERLTKELKRTKQELQAATETSITDVPAAASSWLQTRSSLSSNNLQEVPEQSNTGPRTLAELEEILEPTSKSAKEGSWLSKSFRRTVESPRPSISNTKQETVSSWWPISRKMVGEQTPAVPSGDKTNENGSNNRDTDLLDFFDKSDHPEFTEKSDPTWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JLX7</accession>
    <name>A0AAD2JLX7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1962127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JLX7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="138" mass="15831" checksum="F2984427BE82C99B" modified="2024-05-29" version="1">MSSVEEKEEDSFIMDRTVKFNVGGKLYEISKSLLERFPDTVLTERVEKASSLSTPIFVDRDPDRFAFCPDYMRDNGQARSYDLIQEEEQGIVTLENNVALFRINAQELLVFGNLPHEPGKSNESNIHKIQQLICVFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMI3</accession>
    <name>A0AAD2JMI3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002169">
        <property type="protein sequence ID" value="CAJ1964036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMI3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="308" mass="33851" checksum="57ADE9227B4D5498" modified="2024-05-29" version="1">MATPPLTTTTPSTTAPTKEEADMTQSLAQDRPTIDAAIKSYISLVCAKVLTASATDDGTLSSTSSVPMATTNTTTLTESSKTLLGLIPSSGLVNTSNSNSKSVQQQVLQLARIILQTLNQFTFPIHCTVMADSMMVKKPGASKQHLLELSIAAQLWNGLVQSKQKPSRFLGRRALKHAWKNQLKGEIFTKLMEGNNNDTNKDHDKDDNDNDGSSDAIHQHHQQQQLHWFQEFERLLFYDENTIDNDNDNNNPNANADNDAALIWAADGGAQELAKRRTRRQEEATKRGDSSNIATTTSDTTMMDTISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNT1</accession>
    <name>A0AAD2JNT1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002291">
        <property type="protein sequence ID" value="CAJ1966491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNT1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="GLCNAC TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496:SF6">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="496" mass="56867" checksum="4853A372010771AF" modified="2024-05-29" version="1">MTSRLYDGKEWHEIVDDDGDEHQQVHGKVPLAPILNGDGRIFVSIPSYRDGERCGKTVMDIFQKAKDPDNIIVGIVDQSYEDDKSCLEVYCKELGFNIYSKPSLRKDTTKVILNQVQHKNCPRADQIRKVSVHHFDAKGPSWARALSRKILGNEEFCLQIDSHNQFVQDWDEKLKMEWAATRNEFGIISTVPLGYYEMEHKEATTVTRGCEVEYQDNKVPHFNERGDGKIEHLKKPFLAHTWSSAFSFAKCHLEESAPYDPFTPFVMGVENFARFARFWTRGYDVYTPTQNIIYHSFQPNPEGHRMTEWFHPKDQRHKDEALKRIRSYLGAPDALEDYNLANLGIYGLGKRRTLQQLEKFLQIDIANQVPRPRNAPCMGHEWVPYNMDISPTENLFKHPDNLDPQPEFPMRTECVFYEEEAANAASIDVLEGDIMGELGEGKDGSQQTNPHASPFPSGTILFPLWIVGLVIWYMSFASTPTSRGKQSRQKAGAKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNT2</accession>
    <name>A0AAD2JNT2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002347">
        <property type="protein sequence ID" value="CAJ1967809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNT2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="447" mass="48540" checksum="A11C3E7DB615210F" modified="2024-05-29" version="1">MTEATIDESALIAITTDHSKTSVSSEVSRESQEKDDISTSHRFSERSDFGLAARYPEKRVSSETKVGLTDDEEESEQSDQFDADVEPSTPIQAPRRHTFMAPASEEMVNRYKGMVKSRSLYGNIYEDGVLRSSDFYGDSKLIPFEEAERPDPNLSKYPHSAPTSTKKKESLRRKFDNSDLPANIARPGDWLGSPTASTRKSYTIKPKGVAPPPSPPEDNNVDEPGDDDLATPKSERPEMKKNVLDPPFSASPAIGGGRRAVMSNGAYQKSSASSARLSMPTDSSDPSVQKYKDMLRAKAFSISDFHGTSEESGVRPPDILPLSSPIVSSKKKSFGHKWGAPDPNDEMQARPTDFLGSPIVKRRSYVIKGDISSAMMTSPVSVMVAGGTSAAPIKRASMPVISSSSSMHSHEGDKSTPFGSPANGPRKGGKRVSALLQRFESSKQLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP02</accession>
    <name>A0AAD2JP02_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS23124</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002369">
        <property type="protein sequence ID" value="CAJ1968193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP02"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="507"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="819"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="909"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="858"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1968193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="959" mass="106263" checksum="14A387642A93C743" modified="2024-05-29" version="1">MIIHFLSHKANAQRECVSDIDCAALYRQGSTCLASGQCSNPFIDGCLKSMKPQSEDQRIRLCNSDDDTAEERNCRTSPLNYPEIRIHNQDWEAAIFFSWIIQISLMEFLDVPVTIGVGRDTQESSFYHIENNLPFSSTSYSWDGIRKANELGGNCLLTDEDCVNLITDVWASQVDVMAKEYADGQLDNSDGNGQVEKLSWWVPKYTAVRYPFTVTHLGLSQNHHRVAEIFKRPTAWGDYCNEVSPNNCTVPDGVAEMYPNQDDAGKYFASGYIGHFRATAENNCTGVVNNNTCTGHVVAPPCTWSTFIETQTYWLDLALKSSGPSYVNGGYTYSEMIQIWNAANATQSDVMMQWAEPDTVVEVYRNTGAEFTKVYLPTPSLQCEAARPTTEERCSEDPVVRRGTMAGACDNSAHITKKAIAISLRDSTLALPPAEQSPAYSFIQNFNIDQLHINEMLSHYGAGGRTGYAAREAVCTWIANNTEYLQRLMPPNHPKVFQSRDEHEEIATILAYSLGFVALVYILLSTTITFRKRKTAVFVYAQAQFVFVILFGLLLVAVGAILHGMEPDDVICCSRIGLVSLGYTFQLVALIVKVTALNGSMKASQQRRRVKINPSQLYTSVMILSLLLGFYLIIWMAVDPPKSTEIWTQEPDSITVTSHFGCRSESQYWHTAYIVWEGMLVLWASAVAFQTRHIEGEFNESTSLGMMSYSHFVFLMIRVMVSVVFEGEDHTRSLATSVLLSVDIIAAITIYLVPKMVSSGCSIQELGSRSRLSFSGSFQAVVGTNMPLVPITEKPQRFTSGATASMSSFSGMDRISMLSGAEETESHAAGGEESKANPKSPSGGNGLHGKQAALNQMHPRSSVSHWATGGSTESLNTSNGGSPIVATQQRKQQVNNHKPTPATDNGQAMAALKQQIWQLKKSLVRKDEENEDLQQMILFLQDTQTAQEEEIQRLSVMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JP31</accession>
    <name>A0AAD2JP31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23287</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002391">
        <property type="protein sequence ID" value="CAJ1968543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JP31"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1934142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1968543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42624" checksum="331AC591A9E97EBB" modified="2024-05-29" version="1">MTSTDVSSHPSFPHKEFTKIIGKPTVEAITTLRQEMFANAMSVPSTSGGGAHGLLGAVTTAPDYLTYSNQPIAFNSPIHPGDPPVPTNETAVQITNNNRAYENNLRTYTTYITLVNSLKQLLIGAVDDIYIASLKDQHMGYANISTLTMFTHLQTKYGTMKPAELEANRDRLKEKWNPDQPIEHFFNKVTQVRAIATRNGSAISDDATVTLCRSAFEGAGVYGQAILTWDTKALTDRTWTNFEPHFLLYEEARLEGLKTAKQAGFHGANHVLYTATGTPVLTPHTNPANNENTPPPLCHRCNNANATPPSQQQKAKPEFLYCWTHGLTKGKANHTSKNCTEPTEGHMKQATIYRRYGGSTSFDTLTNRTNRYQQSTNDGETRPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUQ9</accession>
    <name>A0AAD2PUQ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUQ9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12183">
        <property type="entry name" value="LDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058205">
        <property type="entry name" value="D-LDH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43026">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43026:SF1">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1951996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="56227" checksum="C9AAF7C80B671B51" modified="2024-05-29" version="1">MATNTNEAFAILKDAVTFEFAEDAYLKEIAKLMTKEECDDGHVFAKEGEVSAKWFILDEGTVLRYKGPVDDNHILDKLEGRGRVTALFHSLKEEHVSYSTVVASGHVKLWSVDAKAYRDLLASHGGFALQLAAHLARLLRHESKVSRALAQARGSSPDDDKGDSKTLRVLCYDTTEWVRSGFGPALMEFNKGLENLQIVMEYTEDRLNARSAAYATGYDAVCTFVNDTADSDVIRMLSMLGVKMIAQRAAGFDRIDTKAALTFGLTVARVPAYSPYAVAEHAMSLLMTLNRKITRASSRVHMSNFTLDSGLMGMDIHGKTVGVMGTGKIGGILCNIIKGFGANLICFDVFENDEVKQIGGKYVTKDELYEQSDVIFLMMPLLPSTHHTLNMDTLPKLKQGVLLVNTSRGGLVHTGALLEGLKTGRIGGVGMDVYENEADYFFQDWSAKQIEDPQLVSLLGNNNVIMTAHQAFFTKEAVDKIVSTTLENLRDYAKGMTGLEHPNSCLPKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV01</accession>
    <name>A0AAD2PV01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001829">
        <property type="protein sequence ID" value="CAJ1953539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PV01"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1953539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="132" mass="13915" checksum="596209805E030DC7" modified="2024-05-29" version="1">MSPKCPDRLLPEIQWKHPKHYVDYGKKLNLNQIGGTVPATVPGTSPATSIITGGRSTVAGSVNTPLRLAGTTGNQMMQVPAGMKLMQIPTQGGGNVTVPYSKNANGEIAFSGMQRSQQGFSGAQVRQGFDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PV13</accession>
    <name>A0AAD2PV13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS13953</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="370"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1563"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1644"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1953284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1769" mass="200257" checksum="BC6A0B4791B830DE" modified="2024-05-29" version="1">MRSGRSRENVSVKAKASPKPLPGDKEFENYLALTEYEVLQDPYRGLQSRQQSLETGISITTPWNACVWGTLTPEKNEHLDEVAVVRHVGHCACPSMKAWTRKLHESNKKRGKGRKRAKLSSPSQLDDFYAVGIRPTDKSYRCQCDFNPLCLASAGGVINDILVERSKDTVEETNGGTSKSAPGSEEPGSMQMGTKIHRKPLHENLKGDNVDNSSRLSATSVLELVDDNTNGKNENDDVFTFMEIDPNTKRNAIGLKPLCQNSRNVEGDPGHVFTMELPNIDEDKIHYSQPTKTRIRLLRKSFTLEGSRIERYISACLRASDYEFNHRENQNVDKYLSTIAAWERTLRFVSPARQSKVDNLSALLNLSIPPGIENLGATCYLNTQLQCLAQNPVFLNGIFSWRPGNSTHSMNAVISKMQLLLAKMVVGGDCKLSTLDFSNALGLQHNEQQDPNEFARLLFERMEESFQQCDNEGDLKNLLRRIFQGTTTYQTICMTCGQSSERSENFMDLNLPIVRQEKTKGNGREMKIKDYFGGKMVDTDVQHCLNDYLCAEVLDGDNQYFCSKCSSKQDANRLLKLTALPPVLNVQLSRYVFDLSQYVKKKLSDKVLLPTTLSVPKRDGSEVCYKLCAVMRHQGTSAYAGHYIAEAMDWVTGQWFEFNDEVVKHLPAGPSNSYDSPGTNEMSEVQVAPIGSKDAYNMYYVDGKYLKENAIQEIVRRESRFTRDPIGSTSDQQDILSKIAQQRTDKYSTLYDMCHKDTLLADRLRRREIGIRKYMFRDSSSLAVVSVEPLIWVDADTLRKFLRLDDGLDERIRSEGPILCHKPLLCKHTKLHPVTSRRGKILHRSTFNAYVSLLKAEQSRFREESKLCGDCNPVCDVVISLSKNLICDQCSKSYSSLLATRLKLLKDIKELYDCLDPSLDNRDLQFYSEGEDFDCSGDAFVFAVSKRMVTRYRNSFKGLIHKFSKLNDETAGSKLASKEDSYLEGLDRLDLSLFQCEYDSDLTNASSKRTANVTITELDMYFNSEIICEHKKCNEMNDRRNVRFVSWGVWQRLKAVFPEAIELKRARVLKGAHFEDHGCATCREEKTRTEETISDLKKWAKDTSEDRELMRLLKENDVNCFQTDPSASYRLVHRKDLSHWRSVVKKVSEARQLCFKKSQELLKHLSSRIFPKHRNDMFQCNQFLDGNFSTSLVPLVCQERKQVIHDHIFQSLDSNCDKEEGTRALAIWVTVLPDPTYRSFVASLAKLLQMLRPSYLNQHNVERACQSSGDQGHAVFSNYERAADAYHPTIQSIEKEQGSEDCSAFTVVLDGASKFYRVSPPVCHVEQSADRMLPFLAVDYEFQEACINHITANNIPTTKSKRSAVCVDGTNPQEPILVESDVECAPTLPKQYKLRVFNLADTGSIGEAINCLENRSTVLAVEEEKGLFGFVRRSTRKKKSQYPLGCLINEMETKVDTHLNVAALKLLLFERCQVSITGRKLTLAVFWKGNHQGQLDIRSEWIEKPVSDLVKDIQAQSKEEFRSETLYDPSTELYVFHQRDNTGSSQGLDESVMDSLLQTAIYHKTEGTKTSNGKNRKRKQSAERGFQGTLLHSGPSVQKTNSDSSDDGQRISKPMDAALRKDRATNIPSVEGLAALEKPASCLSESDDDIPKASPFASRQTTKVKLAENSNDDKHDDFHHDIVYVESTQEFPIDTKDPDKRIDFIVEGPSNNCILHDSVVSQVLSILGESADQSTCWDAVEWAIKTHPDERNQESLVATVVNKVLESYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVB8</accession>
    <name>A0AAD2PVB8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS15171</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45926">
        <property type="entry name" value="OSJNBA0053K19.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="749"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="866"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="640"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1275"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1322"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1954578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1348" mass="150196" checksum="42E175E0220352AD" modified="2024-05-29" version="1">MDETKQQQSSPSPAYTQSSLNRLLYDPPRWGWSAVGGIADLLTPHERSRRRSTQVAFRQKIRLEKEKEIAKQNESIVLNAPEMAAPIVQAAPAQQIAPTAGESVELEQMKPQQSAPEQQNPSQQEPPSEMESSQLQQTQPDSQMQQPPSQVQPKVQQDQRLQVQIEGLKTIAPDPTSLPTSTASMRSEISTIPLTLTATERNPDQSKVDRSTSQSLPNTRLEDHSALWGMSLKPLTEDTANPLSNQNREIEASVEAGRDGILDMYSYHRGREGMEPRDPDSGEILAASIPTDTNHNFDAQKLLATIIVEFPLEDYDMDTIATSTGEESSVAMFKETLQWDLDDSATPSPAEFANKISEEYGLSFGQMMDLASSIQGQIDAHIRQSCNYCAPVAISDPTGNERRFNAVVRQAQPYDYLVRGDGGGVLISRKRTQKHQLPFPFPSKPKAQSISAIPTTDTTSNKSGSRKGPKKGYIKQVIEVDEDVEDVYSEEIQKRVMQASKQRILTTPTGEKSGLLELKKNFHCHICHKKSDLTYTFACGIGNHVYCLVHCKNRLGLDFDVEKPAYLDYCPICALSCDCASCSRRLKNVAYDFKKHCTEQNAEPCKVFFPNVLEKCQNTSATASTRRTFKVIGIAPDTTERSVSKKSGQAASKSTDAVNKQPRPSVPKPSLLDFPREVCGAVDIDVGHPDDYMTVYSCDGSFRAHSVPDVWEKEQQRALELENEQKTSDSLSQEIVVSNCEEVVEDGNVDYCHMCGKAGNIICCDFCPRTFHQACMDNRAVSGEDDGDQKWECPVCKSEKVGLPSDLVDGTAHHEMIISSIEDNDDLKKDENGLRVFAIIYEMVNKLMVYDFGIIFQKPVQGEKGYRKIVKHPMDLGTIRTKVKNGWYIDAKAISFDAAIAAALKDVELVWHNCFLYNALDSAVYRMAGVLRRRALGIRKKSFDHLLSDGVKSTVGEYVTLCERGRLQLLLTQRPKNIAESKALQAKQPKGKYKMFVNSKHAKTKKVAILDPSTGRILKTYSSVKNAVVAYSHLAKLGHECEWTEPDVAKLINRSTHDSKCLIFGYRWLPLDDLRALKVKFRKKAPASASTILEMNYENCRYLFLSIEHALSYFFLSPGVEMSEARSQLKRVPAGTDYVELFGVGWRRPLFEGLNPEKGGTGTSETVSFENQQQSLLVDCSVVKMDSCTRRTMMAFGTETAAFEDWKRANSASPLSTRPSSEDLEHFKKEYLEGLRHVDGMVWRRCNVTERNEGQPKPAEKDAVPVSTGEASTDAAKDTVEPQKNEEKDKNAEQSKKEQTGASSAAASSGHSLESPTTLGKRKQDSDGEQQTEPKKQACDDREAMDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PVC9</accession>
    <name>A0AAD2PVC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PVC9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="208" mass="23420" checksum="C785CF0812CD1B42" modified="2024-05-29" version="1">MIRHIQEHPRAKEAQARLPIKKRKLRDNSYVKSINERPRQNKKLTQQVATNPSAGRSATISSDATMDAIIQDINQLLCSGIGKSNRKKRLKKTKKRWRTELGMSKVQFSNGVWHLARNKANVQIQFENKIILNSPLLVDEPRDATDSSSSISTESSTNTILDAPFTVPDTNDEDDTKVLGMRPAVDQEGSWINLFHPSVWGLGTSMWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWE2</accession>
    <name>A0AAD2PWE2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS18587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="606"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1588"/>
            <end position="1604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1960171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1623" mass="179794" checksum="4B7EED7F617E8DF0" modified="2024-05-29" version="1">MAEGDASSGDSGIAETTVKQEDSVNSNPSPPVENPSQGATAEKDLQVGTEDPTESLDQNLSESSGSDDGNQEDGPKTEVVLDPNVISENPAKTMDDSDSAATEKAKGSISPPKTNGKTVTGALSGSLLIQQTNVCKVIKGEIHNVLNVMRTDARYVSPLRFMEELPTDEHHPLLTQLRDLHRTLSEWELNHHNEQPKAKLYLPPFCAAVQGRDISASVTGAALHSIHKFMLYGFLANEGAGPYTNIAKTLLNCTFEESVVDPEEEELNGSATSQNHDDEQVVLKLLDLSALVVRCSSLELEPDIIVGLLDTCLHVSHRAKRASSLLKSAAADALRHIVLEVFSQPDLMKARVAILNKLASLLNPQKNAESYVVNSLTLVNIALETMNGDPSQEEINILQNDMCKFLLAWSTTHDLVILSLTMRVIFNLFQTIRNHLKIPLEVFLTSVHLRILEHSSNHEEREVALESLLEFCQEPALIKDLYLNYDCDVNCTNLYASICTTLGNSAAPGTFTERSVAVELDNTLSANSNPKGSLAQKAAIAAAEVPVNALNTLALEGLLTIVDSIARRCKNTPKGGKTEKRSSQKLNPEYTEEVEEAGIEKLTEEQVQERKKQKANLSKIATTFNTGKTKDWMKTGRELKLLDGTPESVARLLYKAPGLDKNKLGAYLGKGPEDAYPFEHKVRLAFVKYFDFTKESAFAQNLRLFLHKFRMPGEAQMIDRFMETFSKELYLQQTGVGSCVFKNADAVFILAFSTIMLNTDLHNPRYKGKRMTCDQFIKNNKGINSGEDLPEDLLTQVYTQIKETELQVQREIGDLMTHADAQDAENFRSAWSDLLSRKDVAEAAFTTPEDARKTMFQAGVHEKDMFIVIARPALKAISSSFVRSWDDTCVLQALQGLEQISRISIYFGLDRILNDVISFLLHQGREFITGCISLEYAGIDSGAPISPNPDSEDDETMSLVDTESPIPHALLKVRDYSMLPKKIDLAGTAAYRGLLTLNMGLRIVRMLFPRVKDAWPKLVGVLASLRDLRALPPGLSDLDDFADSDGNVLPLSEFAQESQRKLDEYYRGVTSRGSGGDQQAQSWFSLGIFGEEDENGNKPEPKLMNQSPNGVRLENSANAKLLREIGQKNEIEKLMVFGPNVKLPLLKQSISGILDSIGKYPVPGSPTYEQHSAFALELAVRALFANRERAGEIFPLFFAKFASVAEDINMESQVEGPFLVERIAITILRSVIHLYSVAALRPKLKASLFFIPAFPTDQFIGKIADRMACGLAIILRSMYFLFKSPEEWKFFGDSFDVLAQYAEGRLLVFDGMASTIEFAVPELPKGENEDIGIEEYEDLMEEKKTLSFAACAALQGVMFKFIYGSYKKDTTFALPAMVCIERTYKHMVKLLLIRQFNKDPDADLESVPDKDLWYRVAMAMYSVCAASDPKTSEEGLHTARRHMITSIFMEEIPDEKWRTLLNTMIGKQPPLTDMSSRVNTFSLIGQLMIRLFPIMTRRKQNWKDLTDITKNIILIADENLRAGKEGGKATRSMFVFTVKIVTELANQLSSPAFGGEKRYCAWASETFAKVLDKWGAAKGLTNRKKTDPGAAPEAAPEADGASPSKDATLVKGERDVTQLSGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWH8</accession>
    <name>A0AAD2PWH8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS18731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002058">
        <property type="protein sequence ID" value="CAJ1960438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWH8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041900799" description="DOMON domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="7">
        <location>
            <begin position="74"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1960438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="607" mass="65766" checksum="DB8BD07183D77130" modified="2024-05-29" version="1">MGGLNNKSVLLLALLLQLLLGNAPVVATKEVAEAYFDGFVETTEQAGYTDWLNANFGTSYSQHSFLSTSSATGSGAAVFWTINGDEISFAVAARATGWLSFGISEAGGMLGSDVVYYETANPDELVDSYIMEARAAPLKDDCQSWNLIAKTITDDGWMILEVNRKLDTGDTQDHTIKIDAGGFVAPTRLIAAWGDTPTVSFHGTNAARNSVRLFADGSVSVKDALLTQLNSTTVGIFDVRESNYEIPGQDTTYHEVCRTAADILQEIGVTETPLTIIGAMPVISEATRAYIHHFTVYSKEECGVGTYDRSMIYAWAPGDEGWALPDNVGFPLFEVADRQAISIEIHYNNPELVQGELDSSGLRFFYINGEREQRAAILELGDPTVSLFGETISDGLTQYEFSCPSACSSAVLQQQGVTVFGEYLHMHQTGVRMTNDVIRDNEVVHTSKVDVFEFDQQGAFLVQQEPYEVKPGDAFRTSCYYRDGAEFGLSSQEEMCIAYVLYYPAQEAGGFPWMCPYGIGFPICDQQLVPSDLQNNIQALNRVFGTPSDTCAGGGSVDPTDPPTDPTANNSTTLAPTSSTAGRTTGVNTVFFTTLIGAAFLFLTVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PWV5</accession>
    <name>A0AAD2PWV5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS19705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002104">
        <property type="protein sequence ID" value="CAJ1962474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PWV5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1962474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35104" checksum="9DADA9F6AAD175F2" modified="2024-05-29" version="1">MLDFDLDDDYDTALFFALAYLTQQQTRRPKYPTERVNWDEHLQKELYQNSFHRTYRMSYPSFMKLKGLLGDKIVLNGARSTASSGTAPIIPQVVMACGIRWLAGGSPTDIKNAYGLTVSTVYRLRDLFLDAVCTTDELDIRLPDLSNPSEISKFRSDFEKLSSSGVCKGCVGVLDGMLQRIGNPSVACAEGQHLWTHCHSLRIRIEMAFGHLTNKWRVLRRPLGGKLARQSQVLEVCARLHNFGINERILGLGYLPTLRPFEQIPGSSAMRNLLVDHIRAYGLTRSQQNVARKREHEKTFDYCEKNSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAQ4</accession>
    <name>A0AAD2CAQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1909079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAQ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1909079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16147" checksum="67D267FE92CF4380" modified="2024-05-29" version="1">MSGNQVILFLIVGTNEPLYEAEIHKRGGTGNSDAVARQNYFVVHSALDLVEQAAWRTQNMYLKVVDKVNHQHVSTFLTAGNIKFILLHAGKSEDTIRSFFNEVYELYVKLSMNPFYHHDTPITSREFDRRTRALARRYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CBR8</accession>
    <name>A0AAD2CBR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1898976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CBR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1898976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="291" mass="31870" checksum="AEDE57D081B816CE" modified="2024-05-29" version="1">MSSEFLASMTFANGNNDLGCDCDECGVPLPAPIMAAVRKRKWEMIERRPMFSTQERSLISRQDGTSIWKTVVPVGSDPLVEFGQSHRILWVKQLDPKTCHIKSIGEGIIGSSSEEDSRKRLDWEEGDIYLVKSNGGKAIGWTHCLNKEENAGTLESSTAKGNSDDSTPSVEPAILITIKIPLSKKSEDTTPSEDELPDMDGITSDSWASYFLKLSQIVLNDCKEHSPGLIKLSEEYRKSVRHAMGKVQSKAQAIPNMTTGNGKAPIDSFALAPGTPMPRSTNQVDVATEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CEF3</accession>
    <name>A0AAD2CEF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS2685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000202">
        <property type="protein sequence ID" value="CAJ1932089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CEF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041920725" evidence="3">
        <location>
            <begin position="24"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1932089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="237" mass="26352" checksum="1171766114D01534" modified="2024-05-29" version="1">MKVTFATTAASILLAQSLVLVQANNQQIIPAQQRLLIPPSVFGIPRGGGLFTDLLSKVTESSPEDLKAEAKAKRSEVNDLVKELQAEAKRSSQEIKDMANERAKELQSKAKEILKEEGANAKAKAKELEDRADALKKKAFKKAEDIQGEIEAKAQKKKDDLEKELTAKAEKKANELKAELQAKKDSKEKELRSKMAVKEAELKAMAADKEKEFKTKAQQKMKSLESSSWMKKLKSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CFB8</accession>
    <name>A0AAD2CFB8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1922052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CFB8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47215">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47215:SF1">
        <property type="entry name" value="F9L1.8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042262865" description="Oxidoreductase FAD/NAD(P)-binding domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="187"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1922052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="309" mass="32913" checksum="B49649344C2F173B" modified="2024-05-29" version="1">MLSLISSALCLSAIASVNAFVPVHKAASANTAFAPTQSYIQPQPQPLQINGFKREKCVLFMGWGPEPVWSAATVTESEAANESGSSVRIMVQVPAETAAEYKTPGQYVQVTLNEETKPLFLAIASPPDAENPSFEFLIKKTDSNGWITGAADGSQIQISQVLGNGFPMEENLEGFKFDFPTQNVLLFAAGSGLAPIKAAMESGQLNVGGGGGGRTARLYYGIQTASDLCYVDYFPKWEKMGFQVVPVLSQPGPEWGGRTGYVQNCLEEDGVPIPRNSGALLCGQKGMAESVTAILTKAGVFEGRILTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CI90</accession>
    <name>A0AAD2CI90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS4158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000391">
        <property type="protein sequence ID" value="CAJ1934821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CI90"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.20:FF:000001">
        <property type="entry name" value="50S ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_bL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_bL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_bL20_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1934821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17741" checksum="E8DD7AA1DF20A895" modified="2024-05-29" version="1">MSFASISRGLGRFALNNANTVQSLAPYVIGSTALGARTFASKKKKNLLKHAKGFRGRSKNCFRVAIRRVHKSWQYSYRDRRRKKREWHKLWIQRISAGVRQYSWRYSEFFNHYRKSDLQMDRKILAELAANEPFAFRSVLQVVEHQKMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIC8</accession>
    <name>A0AAD2CIC8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS3547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000324">
        <property type="protein sequence ID" value="CAJ1933995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIC8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1933995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="227" mass="25256" checksum="661D4B263062F94E" modified="2024-05-29" version="1">MMMSQSNDTTSPSRSSSLSSLDRETSTTSSVSAPIEIQCVDPVIASIFQPGFASNYDHEDHINNSEHDHHIWLHQGEKENGLPDNIEYVIMDEPGEEIPTITRKRSRVSFLHRPHLATNAKNCHHPTSTTDTSPKVVQLSEHGTHYGKAQILAWRTQRASKAALRKALQLPKKHSPRAKAVALKSVEVVKEVSIKSVELALKHSPINCHHNNNNNSSNNNNSNKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2024-10-02" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CID9</accession>
    <name>A0AAD2CID9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000084">
        <property type="protein sequence ID" value="CAJ1929517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1929517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="374" mass="42865" checksum="5DB3BF5B1DD41AC2" modified="2024-05-29" version="1">MFYVCKVLVAIGSGYSTPFLPEHDAILIARCMMQIKAKFDTDEGLNFIQQYYINQGLKKFGDDGKDAVDKELRQMLLRDCFTPKFVKDMTASERKKAQSAMMLLAEKQFEKTIKDRLVYRGDGTREWLSREDTASPTASQEAIATTCVIDAHGGRDIMTMDVPNAFIQTYMPEAKEGEDRIYMKITGMMVQILIDMAPEYREYVVLENGKRVIYVRVLRAIYGMLQSSLLFYNXXXXDTASPTASQEAITTTCVIDAHEGRDIMTLDVPNAFIQTYMPETKEGEDRIYMKITGMMVQILIDMAPEYCKYVVLENYVQVLRVLYGMLQSGLLFYNQFQSDLEAKGFVFNLYDPCVANKVVNEKQQTIRFHIDDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIH4</accession>
    <name>A0AAD2CIH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS3599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000335">
        <property type="protein sequence ID" value="CAJ1934124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIH4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF8">
        <property type="entry name" value="RE57120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="80"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1934124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="297" mass="33199" checksum="BC21E292032A5CDD" modified="2024-05-29" version="1">MSLQCLKHNTRQSVASLRCISSITKRETPSKLFPEKRMHPSHLKGTRNIIRRFSENGIPSELEQAVAEQQMIIRHSKADSVVSLNVGGKDFVTLRSTLQINPVLYDRVLRAEANNELIKGAVFVDRDPTHFGSILQHLRNVADSITLSSAKNRNAWLNRFSSPRTEVNIQIPGDTAKLRELFIEARYFKIKELEDVVSGYDWWSWLASLLNGGATNPFHSALQAVKIARRTLLTTGGLGILIGAQNEALWSEVTAAAKTAYAWITSRAPSIESGWFSSSADQDPEPKPKMSWFGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CII1</accession>
    <name>A0AAD2CII1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS4294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000424">
        <property type="protein sequence ID" value="CAJ1934957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CII1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1934957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="631" mass="69021" checksum="68E52870567B1E17" modified="2024-05-29" version="1">MEETGASYHQSPNDTSLSATATTTTATTTAAAQSSPLPSELNENNPPSPPSPPADTATTTFKIEDFECILCLRLLYEPTTLKCGHSFCRTCVEELYQQNHAKCPTCRQVLPIVHHYSSEKMSIIAPSFTLCKFLEVAFPLQYKERHNEIIEMYPCRAGAMDATFTNSMNATTTTTATTPLPLFYLDPMVPRQVMQLNIFEHRYLLLISRCLEGSRHFGMVGFMSRRMIAERRRRRLRQAAESTVVANNNNNHTIDPEDDDDDDDEALSMIYGVEVEIVESSPQPTGTMHIQVKAKRRFKIVGDTWRQDGYTMSNVQWLALPAAECTNTTTTTTTNTTATTTNPLLESLPVTQEDANETQDDDGGDNAVPAGEISTFNAALSESQTATVSQEPAALSENDSRDAQDAAAQDDNARAIQLAQALGPLVEEWKALVVAEGWQRYHGQLAQTINTIGPMPEANDIRGAIDRALWVTALINPLPGMGVAPEIRPEVLEAAAAATDNVVPLLLIVTHGMRKSIEYLTPNAVLVWMQYQLQKLYCLLLGRGTRRLGPPPPLPGTHQMVNALLRLLVVCLVLGFFWQRILAPKRAVLSSSTVSSSLSSSSSPAEEVLLSAAAAATASPNMDTETAPLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIJ4</accession>
    <name>A0AAD2CIJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000473">
        <property type="protein sequence ID" value="CAJ1935457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIJ4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042243005" evidence="1">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="74" mass="8163" checksum="15E690065258CA6A" modified="2024-05-29" version="1">MGDFGEVMVALYFLFCADIARGSLKDNKEYTTFSVPLNGWINCPINGGRSGDDGDNGDDMMTKNKYCQVHFSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CIP8</accession>
    <name>A0AAD2CIP8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS4882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000502">
        <property type="protein sequence ID" value="CAJ1935731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CIP8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1935731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="500" mass="54238" checksum="47D958C1FB919873" modified="2024-05-29" version="1">MSLMEDDDLDFLEGGSDDGSGFDASALLADPILDDDDSGEFGLSNAAGSSGGIEGGRPLSMPNNPTMPNSSNLSSFDNNNSSNMGSQIKMQGTMQQQQNLFQKQPQQHQQNSFSGFNQDNNMNNSMNNSMNTSMNSTNNNMNNMNNSMNNMNSSMSSMNSNMQMPQHQLMHNRHNGGADSFMPLNDTNGMQVQESQEVVTMKMQKLQQQIQQVQSQIQHVQFQSNRLEMQSSHVDAQNSAPQNGMSAMNMPQNHLNNMGNMSAMNNMSNMNNMNAMNNMNNMNQSQNQQSPFGLQGMMNPSSGMNRRAPDRSFSAPVVPRSVGFRGNFMEPQQERRHEKQPQAGTSLAAMAASLQGGGQASSGQGSTGGEPPGNVNEAMEKLCESMRRSAMSRSMVRQLSGRSAPNSRGMSRSKSGGLPRGTLGRNASGRSIQRAHSGTDSLRGAPIRRPTQDTKYRIQRDALSNSGGPPGRGVFRHKSSQGALGGTTRLQIDDSTVGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CLQ7</accession>
    <name>A0AAD2CLQ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000557">
        <property type="protein sequence ID" value="CAJ1936565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CLQ7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1936565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="450" mass="52225" checksum="636E48EB8F49660F" modified="2024-05-29" version="1">MSKDRCFLCHKSSGQRIQKLFNGCEHESACLECLRDKYIILRPHQHQHQHQHHHYQSHYPLKCFHPDCQRVLQDAQIKRIAQSKNELQTFRSLNVICKYNRTICKNNRTRFGEHWRDLLQVAQAMKGMEVCRCPSCSFVIVKNGGCDHMTCFCGTEFSWAKVCNGKESQTIFPILFKKNLVLPPAAAAAKKNRTTIPVRLDDDAEDGYFRNGMMPFDDVEDEIDIDPPNSTEYHQIGAEQEACHNDDEPSATQPSREAPLPSRLLNGDVKNADWEHDDYCIILEHDDEFSAEDNSWDTLLGGNSSSHHTAASQSSSWEEVSEVSSVQSFHSKMGMSFLEVARSNKSSTWPNQEEKEPLRTISEPSLAPRRMKPKRIMSQQKEQEEYDCLTFFDADFFFEGAKGGRGGKAKFRFHNEIPRRYRRRDQHQRSSVRDYDYNWYNRGVRPKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CME7</accession>
    <name>A0AAD2CME7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS5759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1937668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CME7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1937668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="436" mass="50141" checksum="CF790FD9F85EAF16" modified="2024-05-29" version="1">MGRQAARMSHGGRRRSSMAQEGNPLKDDATLRTQMIQLDRVKSRRKFDPWKKSFLKRFESFLDQSGVEKAQEAYEQFSKEMDRTVSLVQKCEELNQKGDLTNERATVKGRRALNEMVNDLVLRWGAIKEIIPGTGDEEELRGYNKFQLGAILVRDDFSEYERMEYVYDTIHVFGSETLSEVADRLHIEQFANYQIQFQRFCDLLADLGLYEVMMACRHFSNCEDDEEQSLTEESESFEEEGYNIILVDLKTASICKMNVDALEAKGVISLGFTDMEEPYIMQSCDTMEKIEEIKHKLNNHPSLGLATNLVVKRSTVMENEYTELEEKEAVTSMWGITLKSTNKKTKKNEELFFLDPYTGAVGELNRQVAIDSGCIHEEKNEHNNLVLREAEKEDSQWETLRGNIRDIIGIQMEAPEGRDDVSSNMRVGSEPISMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CMU5</accession>
    <name>A0AAD2CMU5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS6757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000857">
        <property type="protein sequence ID" value="CAJ1939832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CMU5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1939832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="91" mass="10163" checksum="267EC9B604039499" modified="2024-05-29" version="1">MEKLKQDKKKRPTPGSTSNDTENNCGSDQALKKLKIFSDDITNVQYTSGKASGSFTSTAMDVQNENTTRETTQEEVLQAQFQLMRAQKEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQD0</accession>
    <name>A0AAD2CQD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001057">
        <property type="protein sequence ID" value="CAJ1941668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="135"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="638"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1941668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="90512" checksum="74033EAE1E403D0A" modified="2024-05-29" version="1">MKDNKSTDSSSSSSSVSTASSSSLLNPNSTAVDADLQGINLLQEIFPDESLESLKKIHATRLQKCHYDNISATNSSADRENFLDHESNSLLPSSSLHYQDPILEMEERVLHDHHQEQSPAKAGRSEEEEIYFFTAVVYRDSRAGGLGMTLNELPNGDVQVCDMKPSPMSPSANAGIRKNDILIGINGIAFARSFPIHRYIHHHTTSRIKDIVLSVQQSLNPIVLHFQRATIAHSRSLLDASDQADVNYVRQQQQMEKQQKQQMEEEQTVHQFAFILAQRKLISSNQKQLEVSQIIRNFHYRAQQWEATTSLTTPSTPYAHIYSQHNQEMDVLDGIRKSLSTRIVNCFIEEADKGKGAAKLAYTIWVYDVESGKEWYAPLRYFEDFEDLRATANALAPKECKISELPFPMVTSIWDALTSRRQDVLDEQVQQESCRKLEFFLRVLCRLVYTSPVVNANVAKIAIHVQSFLGTEAGLSSTQSDKGHFQSMTSSMDYHSWNVRQLLKRSLQRYMWRLFQLDIMQRIVNDFVDATRARTPSLKEIETLEAQGRDKLKGHSMKELKDIRVFLDELVDLLLEGCLSEMKLISERPEYEALREQFANDESKLNRLSREATREQVEIEVYVPLRSVVSRLLVNGWRHDDMEVQLKSKELIKRPQSEGTFRIPRESISPSQWESVAFILRSGLGNSTLPCIKLQAIVDAAREVSRLHAEEHRGKDLVGADDFLPVFIFCVVKANLERPCALCVLLSTLCDKMNAIGEIGYFLASFEAVIAHLQQLNPEEDIDEVSSTGLSDVSLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQF3</accession>
    <name>A0AAD2CQF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1942988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="636" mass="73175" checksum="CA56E84AFF9B33E0" modified="2024-05-29" version="1">MDQYYMNTTLKEDESMIPLQPERDHRTRRDNFSSSSNLDAGAMASNSLSELLGISEELEEEMIQFVKSQRIREWARQFRRSDPRYQILNFFNDVAQEGAKNMDQMGANTHLVSPLLRAFYKSSVFTVWRPTSYDAIRRMMLGEGVGKGLDIKGKSAKKGRLSGFVPFLQIHQEEHKKQIRTLPKDGKIRVFYNSKPNREKVVAFLQGVRVEMVDTVKKAKEIVEDDSIEDDETNEWALSKLIWDMTDSTINLIDDYAPKVFGIEVAERLFWEGLVVRQDIRRETGSVDDTGRPSEPNFQNMNFGALRPHGDADKPTPQAVILLYNDPLDDNQDPLDPRDFLMAYEEPSRVMPVVSDFDCFIVGTRGVKYDAPLPSDQLEVSKWCISQIESILESEKTSSSWTSRWLDVLKTAASKGFHPTIPPLGFSDPKSHSIMKHAIHRLQKEGAVRHGAECFNYYFPQELDEEFLVISDRLAGQSLPWKYVDQTGLQEILKEKIDQGYTFPINPKWILCDPGWKDVFDQLRASNASYVQDSIKVWYPPGSGLLDKIEDINKRFPDGFQRKTGGTDDSKEEETEGTAAMDLAELELKYFLTLQRAKRKLRGFLIWRRLLDDRRKRVRDPEKLRESLRAAETANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CQL1</accession>
    <name>A0AAD2CQL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS7240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000968">
        <property type="protein sequence ID" value="CAJ1940843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CQL1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1940843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="363" mass="39640" checksum="CFB6DC4E51C431F2" modified="2024-05-29" version="1">MIFAMKQGTTENLMHFKERFLRQAEVLQNLYGVAWFRDFAVKTKAYAAIASTDTAAQNKFKDDIFKAVLATGFLCNCDQTRTAPLMLDLQTNYCREVHYYPKTVSKAQDMLKIHMEVIKNPGVNLYQGKDQPNKGKGKGKGKGKGKPKDGKKAVCYVCGNEDHMSPKCPDRLLPKTQWKNQDQYVDYGKKLNLNQIGATVPATVPAIVPGASASTSGASSVVGSVNTPLQLAGTTGNQMMQVPSGMQLMQIPTQGGGTVTVPYSMNAIGEIAFSGMQLSRQGFSGAQVRQEFDATQAQTPQAVKTGYFDTSNVFHNAIKGKDENGNDVYLIPCPAGRTNVKLQVDWHYASEDEDLPDLATEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CRE0</accession>
    <name>A0AAD2CRE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CRE0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1942934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="272" mass="30438" checksum="BB2CADAFADC09E5F" modified="2024-05-29" version="1">MRCKDFMIRRSRPEVKRSDPDGPSYPSPNGKRDKREKRPATGAFLAFALTLGVIYLTIFKSRSSVRKQISPAAEVISGSSGAGTPNATEIDKDSAIVECIVSTANWKSDEAANGVLRITVDRRAPDSELFLYLVSEGYYDETHIFRVIKGFVAQFGFHPDKEMINWKAKIENKRKVHRSFKAGKINLQNEKGTLTMIKGPSPQIFLNIGDNRRLDKDGTLPVGFVDDYSIYLGEKIYSGYKPGIGQIASIKNGTVSELFPRMSKIEKCSFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CSA2</accession>
    <name>A0AAD2CSA2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001269">
        <property type="protein sequence ID" value="CAJ1944908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CSA2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1944908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="511" mass="56667" checksum="D59EC7CB95DE8675" modified="2024-05-29" version="1">MANWQVQLDAVSAAKEDVSVASTQSSNVQVGREVAVMHSQAHRGLRYKDSGNLVYLDSNDYKDGKIPEHFDTHDPKWFCLGETGPSLDTGLTFHLRKDSMNANMGTLKELPYMFNYGTNVGGGRNLTHEVESKHMDNMCKYDADVICDVDSASLLVKEGYRIVMDTDVENAFFVSKDGNQWIYREKDGLYTYEPHEGESHCNVCMEIGPTGEACRSCRAHGGFVPGESYHGCIDNTTSQHTSRSQTQTSRQILQIYTSTMSIRSVARVTALSLLWKFTSAQFCTSLKTDTWAGYVDAVSEALDQTGFAVLCPFEISGDGCQGMEEYPEGLRIKEGQSQVLISCDSLLFGYHEESTECVVDCPGRHITVPESSSLTLERYSGLQTVKKNIEGYTPQQVDRANAARSGYHMGGAPGIEAFKVAVRSGLFKNCPIREEDIVIADKIYGPSASVLKGKTKHPTPEAVRDVWVEIPCELLVHNIDLKLHLDIAFINNTFGLTTIYGSIRYRTFVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUT6</accession>
    <name>A0AAD2CUT6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS9975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001537">
        <property type="protein sequence ID" value="CAJ1945832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUT6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1945832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="165" mass="18655" checksum="8632F71F5C9A0D50" modified="2024-05-29" version="1">MMQIKAKFDTDEGLNFIQQYHINQGLKKFSDDGKDAVDKELRQMLLRDCFTPEFVKDMTASERKKAQSVMMLLAEKQFKKTIKGRLVYQGNGTREWLSREDTVSPTALQEAITTTCVIDAHKESLQVMKWMINASFAVHPDFKSHTGGTLSFGGGAAQVMSKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUW5</accession>
    <name>A0AAD2CUW5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001558">
        <property type="protein sequence ID" value="CAJ1946068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUW5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="573" mass="63394" checksum="A5EC40264ACA135B" modified="2024-05-29" version="1">MRLFDFLVPIGIKLNWVSIPYSRAKYDERSPGVTSPHCYTQKIHSKQVDRTLRSLLHPATPKPDFPFAAPATYISEWKSAQQGHLSVKAYSPVKDAILTLISKLRDYYILTEVLYPSIDFTGMFKFSSTTLYGACTLFKLLLSIKATPAQANQASAAAQDNAASKRNAGSDSSDNEDHSLEDDTMVKKAAPKKVKKKKKNTRSKQDDLENHFLKDLSPAQRKLAEATDRKLKNDLDRHKAGPLFLMILPGEMEGTYIFVCQKKYGQLARNVLKGIVPFLTHHLYEPTIVQADQTMGKWIPESEIQLARRKNLVWCTNTLQAIAVEARSDMVEETLEFLDDVIEDTTDVYQGQLSIDMNMANAKDIDDRKTVTGMLDEMQERERQLEDAFIEIKARDHALAAKEEALAQQRAATAALQAKLDALQRQTANHLAISSQSSSNHKVSPDRPEPTMPPKKKKGKSDISANRARNSDDQKPLPKQSRSRSGVHFQQQTLPTQINPPESQIQAVDETPMDGDTTTAVSQDESQTSSSTAASPGGVHPFFLSPSGKSSDGSVQSPSSLTGRGAHRSAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CUX4</accession>
    <name>A0AAD2CUX4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CUX4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="444" mass="51017" checksum="C96B68CC4E277916" modified="2024-05-29" version="1">MLATVSPSTIPTTSHNQRRVSSFEHLSGQDDFHRMVLHANEQRRQNHGWSSTRSVSSCNTDDAGSTSTEHMSNTCGARERRQKEKRRFLSFTKVLMKFLEKKNPTVCKNARNVIRKYKKKSKNEEGGQHNYCGEESVSESMCESIKVPLKQTVGSAYWKQAKEEQRKNNILRKNDDDDYTDFEPLSLDSSSSDCLCENQTAEALSHFASSNRGDNIMTSTTSHKRASSYRRSSSSSCHHSKENHLVTEERKLRKQRFWMLVRVLMRYVEKKDVILYKKARATLENCATRNVRKEPRFVNLIESVQRELKHTVGTRYWRRAEHHVAKHILKKASEQAWEDALAKEASSFGSSLDNLFTPPVPLQEQPQQPQHEQTVVVHPLVLEPAFAPPPRQNHGSSHHWRDPSIPTNVAIPTKKLPAEHHWRLGGCDYYQSPHGTISEDIMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CV86</accession>
    <name>A0AAD2CV86_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (NAD(+))</fullName>
            <ecNumber evidence="1">6.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS8938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide.</text>
            <dbReference type="EC" id="6.5.1.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CAKOGP040001224">
        <property type="protein sequence ID" value="CAJ1944539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CV86"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17748">
        <property type="entry name" value="BRCT_DNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.610">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005932">
        <property type="entry name" value="PRK07956.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="OB_DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="758"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1944539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="842" mass="94035" checksum="2DF8198D16ED64B3" modified="2024-05-29" version="1">MLRARSALAFRAVPFLRKTRCKQPSTIRWLATKTDDETRIYDELKWLSSEIIRNDELYYNEQPILEDEEFDALVRRENEIKTQFPKLLKKLQKESGLGAEATRDGRVGSQSNVVERKKRKHLRPMLSLDNAHDEPQLLSWLNRVSKATVEVMSESGSSSESSDDSTVWILTEPKLDGVSLSLRYEIETLKDGNQSYELSWASTRGDGRVGQDVTEAVSSIPDIPKSLSVIDKIRPKKGDEMVSILEIRGEVVFPKTQFEALSTNFTFSNTRNAAAGILLRKPSEDPEEAEEAKELQGQLQFYAYDVVGDKGAFSNGLDNRAMMQEWGFVVPAPAIVTDLEYTRNSTQEEFLEQMNINQMLVYYESLRRHRLGLGPDSSVDYNWRDFDMDGCVHKVANPDIKQEMGRSMKSPNWAVAHKYPAISAVTELIDVIVQVGRTGALTPVAILKPVAVGGVNISRATLHNFDHMQEMLGNVTSVLVNTSVLVRRAGDVIPQVVSRVGDASTNENRNNESDDWISLETPKHCPACGSDVAWEETNGTAIGPVVRCTGPPMLCRPQAITTLAHAYSRDALDVTGLSESRIQQLMDADLLKYPADIFNYKEKDWERLQELPRWGPKSVKNLQSVTHKVATQGIPLRRFLYSLGLRHMGKHSSELVASTFGTKEEFFKAMDTGLTWEKPTIDEEKEEEEDEEIYLEHPFSKLNGQLGIGESVMSSLLSFAKNKDLSEAAKELASAIKILDEQKVEYQDTAVPSEGKDDVSKPWRGMRVVFTGAIPDFSRSSAHSAAKSLGAKATPGSVSKSTDLVVYGDKGGKKLKQAIQYGVTTMTAEEFIQLVKEHDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZ17</accession>
    <name>A0AAD2CZ17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cryptochrome DASH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS8233</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May have a photoreceptor function.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
        <text evidence="7">Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1943012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZ17"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014133">
        <property type="entry name" value="Cry_DASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02765">
        <property type="entry name" value="crypto_DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF22">
        <property type="entry name" value="CRYPTOCHROME DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="504"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="422"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1943012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="560" mass="63975" checksum="BB8739873E97669C" modified="2024-05-29" version="1">MVVRSALSLSSRMHQQAPTAGIIFHWFRGTDLRLHDNPALERAASLCSQTKSNLVPVFCFDPRYYGESATSEFGSLKCGPKRAKFVLESVLDLRKSLKANGSELLVACARPEDFLAELETIVKDRRTKVVFQDEVCTEERAIEFRVSKIFGSKDKVWGSTLYQLDEIPYEEDLHDLPDSFTPFRNKVEKKCTIHKPLQVPNDLSMPSLDGLDLFKKHAGFIPTLEDLGYTKEQVKFAEEDDPRGVLPFKGGETAALARVKEYIWDKDLLRKYFDTRNGMIGGDYSTKFAPWLAHGCLSPRYVADECKKYEDQRIANKSTYWVVFELLWRDYFKFFALKHGASMFFPGGIINSDKPWKHYPKNVQAWIEGKTGFPLVDANMRELAATGFMSNRGRQNVASFLALELNQDWRYGADYFESVLLDYDVHSNWGNWCAAAGMTGGRLNRFNIVKQSKDYDQHGEYVRHWLPELKDVPTQFVHEPWKMSQFHQTQYNCRLGVDYPNPIAQPYYPKPKSGGGSKNDRRNGGGRGGGKNNRGGKNPNRGRGQRQDMKSLKAGQIRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CZD0</accession>
    <name>A0AAD2CZD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS10561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CZD0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042064671" description="Helicase-associated domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="124"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1946418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="269" mass="30429" checksum="6A980A9117B51AE5" modified="2024-05-29" version="1">MKLLGISSAALCLFMALATTANGFAIIPSSSSSTSSSVLFYESSSADKLDNRFIVSPVLQQVYPKLLEWKQEYGHPNIPLGTPEGRKCATLRRLHIQQKLTQEEVEWLQDLGFLFHSLEDVYEHADFDDLFERLMDYEARHPESNFQVPKKCAEDPELGAWVTGLRRLGADKVDPKHAQQLNNVGFAWFSKSKCGSKFMLQYKALTQLVKEMENDGKTKAEAIQIIIAEDPKVKALVQAQKQIEAKGTMSETRMNYMNQLFGDEWTTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2D1F3</accession>
    <name>A0AAD2D1F3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NadR/Ttd14 AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS10584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001669">
        <property type="protein sequence ID" value="CAJ1946441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2D1F3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053227">
        <property type="entry name" value="TRPL-trafficking_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932:SF1">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1946441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="405" mass="45735" checksum="6D9A044A2710975A" modified="2024-05-29" version="1">MTKSISPAETNLQSKEKIPFFKFVLTGGPCAGKTTALARIYSYLRERGFEVITCPECFTILASNGLSLDFFGVDGMDKIIQNSVMDIQISMEEGLEKTLRGFGKPAVLLCDRGPMDGAAYLSEEKWNSILKERGVTVTDLRDRRYNAVLHMVTAADGAEAFYTLENNAVRSEDAATAMTLDRKTQKAWSGHAHHYVFDNATDFEGKLQRIVDTISKLVGLPSNLSRRSAKFLLKSVPDPKSFPEDVVYHSFEVEKVYLVNQDADKESYSFIRKRTTIDRDGKLMGTVYQITTVQQTADGETIEQKRIINAREYNTAYKSRDSSRHIIVQKRISFLYKLQSFTIHQYEKPSKGLCFLHAQVETGTDSAREAKCKVEIPQFLDVDRRLKGAEDERKYGAYGLSLITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FBN5</accession>
    <name>A0AAD2FBN5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS1293</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000014">
        <property type="protein sequence ID" value="CAJ1927291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FBN5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15504">
        <property type="entry name" value="PHD_PRHA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045876">
        <property type="entry name" value="PRHA-like_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF10">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="253"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="587"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="55"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="507"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="656"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="726"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="164"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="831"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="898"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="914"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="972"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ1927291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="982" mass="108943" checksum="132F0D29EA17C970" modified="2024-05-29" version="1">MTRTDERMPAEAAKAQPLGQTDNAESRNETKMNENTRIENNLKALDDLSYASSLSSTPILKLKGKSPKAKVNKSTKTPTKTSKSSKSSKSPSKKTNKGESKASDTKTKKKPSKSKKTSSSNSKNVSEQKSKPKSKKKSRPSKSADTDEPPKKNEDKVALPPNGVMQTTALKTLTKNHSENGASSRNGDNKMAKTSSSPQQQSDKNATDDALTSMMKLEPVETTNHTKKKSKSTTKSNNCDGGSTHDSEDEEEEAACCLCHCGVDCSDRALFFAKDRKKEIQDSDDDQEYYFGLDDPYLPQEMYDPHNALVYCDGCDRMYHQKCHFVPILKLPQGNWNCLICNMKTTHNKACLPIRNDPKTFFASPPNPSSTEMERKFEFDTKTEKAKLWQRQLKSVKTFLSSQVSNIRLATAALDTLTSVKRNRAMILSNRRKSQELAQTILRMTAAKFKIRQILQSLESLRVSSCTNSLDPIKVGEWCQANPKDACHVVPHGIDYFLNHRRVTPRTAEMKLDQERKKKEQQEASKDAIPSEILCSSPSEKESSSGDKNNDNNDDKDQSKESSPSKKEQSTATSKTEDDDSGITLDDLQCCICMVGDSTDDNDVLLCDGEGCYRAFHMKCIHPEIKLQDLEDEDEDWFCPLCAATANYTHGIYDALREGGDDESDDEEEKDKEEDEDGWDTPHDVFPNSKWEYETAVKFSRGKQNDDTNELLALYLGDDVVGTTKVATPMGSDSEDENDYSLFDEDSFAERQKRKDQDDEEDDEDDGDRSSQATWLSSSVEMNIDKAELNALSEVENSDSDESSSDSVARRRSRRLRSTTETGQAQLKIGVDFDKGNIVEGKRRRKSVDYRKLNDTLFGKLTEMQKANLDDGADYETKRNAKRKSTGENGNTTKRAKSNNSSADSSNVANSTAKQSDPPSENGSVANKSSADTENENDSDTGNNGSGSEKDSDGDEESQSENNSSSEAGSGSDDDDSDSGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FG05</accession>
    <name>A0AAD2FG05_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS5929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000668">
        <property type="protein sequence ID" value="CAJ1938010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FG05"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049227">
        <property type="entry name" value="DUF6824"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20710">
        <property type="entry name" value="DUF6824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6824" evidence="2">
        <location>
            <begin position="150"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1938010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="259" mass="29549" checksum="6E9E4F5E4FEE6C19" modified="2024-05-29" version="1">MNTIQGPKRRPNYSRIGDRLHGPRKHTLVFELLDYATTNPWFSSLSQEDHHPGVDCIVAPLPGIFSITCKYSDETNTTQCRERTLTGEVAEDDISRPTISPPNLRQYHHLCDEELETKNNKKLQNLEKTKKINRAKMIPGGRHCKLQDNDTVLERGSKNNQHAGSKKLLGMVRSQCQLYEIAPKIEKGRIIQDIMKGFKSSGGRFLIREDKRSNWYEALDKPVHDKLGHMLRDQARARKKTGKDKGPQKASKIPVPATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FGR2</accession>
    <name>A0AAD2FGR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS1946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040000113">
        <property type="protein sequence ID" value="CAJ1930454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FGR2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="47"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="181"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1930454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="478" mass="49855" checksum="C5EBDB12366C3153" modified="2024-05-29" version="1">MASTSICRGLSQFSRVAARSSSLSLQHSKRAAAPLTLRSWFSSYPPHEVVGLPALSPTMETGTIASWNKEEGDTFGPGESLCSVETDKATVDFEAQDDGIVAKILVPAGSDEIQCGQPIMITVEEGEDISAFADYVLEESAAPAPAEPAAAEPAPTPAPTPTPPPAAAPAPAAAPSGGRVVASPLAHMLAKDMGYDISSIVGTGPDGRIIADDVKEFDPSTVSAAMPTEGSPGQAAIAAADPIPGVGYMDYPISASSKETAMRLAQSKRNVPHYYLTVDVTMDELLKLRSTLSSVLGEESNLGVYELIIKAAAKSMKAVPSANASWMDSVVRVYDSVDVNVVVGTGDNLYSPVIRDCGSKGLKGISDELNAAVTAVEEGELSSEFASMGTLTILNLGMYGVKSCAPVIREPQSVALAIGALENRIVPNDDLDSEEIYKESVVMTATLSCDHRVVDGAVGAQWLSAFKSYLESPSTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FH60</accession>
    <name>A0AAD2FH60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS2379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000147">
        <property type="protein sequence ID" value="CAJ1931417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FH60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040327">
        <property type="entry name" value="At5g14285-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31766">
        <property type="entry name" value="GLABROUS1 ENHANCER-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31766:SF2">
        <property type="entry name" value="GLABROUS1 ENHANCER-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="6">
        <location>
            <begin position="70"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1931417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="309" mass="34819" checksum="EA8480421F3498D1" modified="2024-05-29" version="1">MMKKTGGMLKLLLSCYRSLPKVIQIGKLDFTFTFVSFAALSVIRTIFFQLLTAYYGWPIRSKMTTDAAASLASIVHSIVLCWLLTEWFWKLGFRAYFPSGKLSDHNSDMKDSAVACLQVCTGYMLFDALWLIGNSYQLNILPLTEFETLVLAHHVLTSFYMISCRVIGAGHISAMILMLTGEISNPLMNGMFVTRFAIQLECCKHSEFIVMLHSLLEPSFAVVYIIFRTTIGPACAIHLAWDVLCTKQGRQNIPLLLSVFWVIMVIGVLVGSGPFIGEAIEMLQDGWKLKYTPDYDYGDRYRIHGGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FID5</accession>
    <name>A0AAD2FID5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS7350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001001">
        <property type="protein sequence ID" value="CAJ1941095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FID5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000151">
        <property type="entry name" value="histone H2A deubiquitinase MYSM1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33418:SF1">
        <property type="entry name" value="HELICASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="253"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="253"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1941095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="332" mass="38131" checksum="4A1921D36C44706C" modified="2024-05-29" version="1">MPKQYDNGWASHIKELKKFKEKFGHCNVRRTQKDYIRLSYWIRRVRGLYKLRRAGKRTSLTDERVKELDDLGFGWEGWSANRDDVFQTRIKEMKEFRKRHGHCNLPCPYAHNPTLKSWTNGMRQKYRQYQAGEKTTLTPEQIAELESIGFDWNVASTSSRRGAKVQPSHESVISNDQGSSQPYETQSYYQEHVSVPMNGGNSPSTPAGPFSGLESLAEICRVVSKEEEHSIHSSSQANTPNKKQRRKFKEGCGHWTDAEHEAFLEALDKFGRKWTKIASTIPTRSTSQVRSHAQKYFDKLKRGHQDVSDGDFGALVESIESGSYNFSQSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FIE9</accession>
    <name>A0AAD2FIE9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS8155</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001112">
        <property type="protein sequence ID" value="CAJ1942856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FIE9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="56"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1942856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="330" mass="38229" checksum="C9DD55ED96BA189F" modified="2024-05-29" version="1">MDLSMRMVKNIPGVISHHWKEGNINWPMLIYIALVHVAASYGVVKSFQASYETLLWAFVLWPFSGFGITVGVHRLWSHRSYEAHWSVRFLLMLLNSIANQGSIYHWARDHRVHHKFSETDADPHNATRGFFFAHMGWLFVKKHPEVVKAGREMDFSDLKADPVVALQHKFDPWFALYMCYVFPAQIAVRFWGEDFWTGFFVAGALRYCVVLHFTWFVNSAAHLYGDHPYDVMSYPAENPFVSWCSCGEGWHNWHHKYPFDYAASEYGISSQFNPSKLFIDTFASVGLVWGRKRGHAAWQMGRARRDRDKAAGVPLPKPAPRPWEVDAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FJI6</accession>
    <name>A0AAD2FJI6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS4757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000470">
        <property type="protein sequence ID" value="CAJ1935439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FJI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1935439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="109" mass="12130" checksum="FC03C9F0D0250AB1" modified="2024-05-29" version="1">MDPLRSWKLGLNKGVAEVHRNSGPSKYHAENKKHANSTPGNGMILDLASDIGTSFQSVRILDGSDFVRRWIREKTLSLNPFGIESVEEGKYPLSLSAEAKCPWDSMSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FL86</accession>
    <name>A0AAD2FL86_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS10491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001668">
        <property type="protein sequence ID" value="CAJ1946349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FL86"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1946349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="177" mass="19200" checksum="A4091A523B9E3DC6" modified="2024-05-29" version="1">MPRKFGLKSIDLTLSSEHEGFHALSKCAQSVGHSNIIDAERKGGAASAAINQNSDALVAKRKSKAMAIATKPGNQLAMNAFMLWMSGKNLNIFSINTTTSAVLTPMTNIFKVESVFGNLDTDTQVPKLIFVALNVVWLGIGLYKMSSLRLLPTTAADFMESVVWKEMSETSSIPPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLB7</accession>
    <name>A0AAD2FLB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS6871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000890">
        <property type="protein sequence ID" value="CAJ1940100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLB7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="185"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1940100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="398" mass="44352" checksum="76414886C05C5636" modified="2024-05-29" version="1">MAQLDCDISPTDSTFGYKENNDDSSADTQEAFLDMLGLSGGMPIGDEIKDEEEIMEESSTATNKASSKYRHQIIPLPARCSRYLYPPEKCLALSINNFFSKAECDQIVQRASTATETGFRYITEASHISPDGTPYPVKIHNPNPHKLSVFDHPPTISRMWSKLNTFVHPLIEDFIEREQCGPALGLNPRIRVLRYDFKDNDRFEPHFDATTMVGTTKQSLLTVLLYLNDGGGVDFEGGETLYLDSHISSKQQIESTLEKSTAGIVKVTPETGKVVIFEHDLYHSGAPLYKGTKYVLRTDIVFAKKDDDSKINTGFEEKATSDNEDESSNVLLVSGLCEDLGLSEQMKDSLNKMGMLEMTMESFLAPGITLLTVMLREELGDSETVDLLVRTACKLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLX6</accession>
    <name>A0AAD2FLX6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M6-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS8437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLX6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775:SF1">
        <property type="entry name" value="PEPTIDASE M6-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041923615" description="Peptidase M6-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M6-like" evidence="3">
        <location>
            <begin position="69"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1943433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="614" mass="66543" checksum="78529241246C33B1" modified="2024-05-29" version="1">MRISAARSVFLVSALTILGCNAADTATETLRVLVCLVQWADHFDRPLIPKEEIEQLWNGPSYSDIVPGESITDYIESNTYGKYKIEANVVDWYLMEETEAEASFGNMGNSVSESGPHIEEILSPVVVQSIFNDGVSLRDYDRNADGKLLGIVFVHSGYAAENGGTDCETGADYLDRIQSKSWGAQERIGNSAYIINTMVTLPAYRGTCGLQIDRVGVHIHEWLHAEFGLEDLYDTGGRYQGSRGATGGIGGYGIMSYAGGQGYRTEYPGILTPFSKMQIGALDPIEIKYDGTYTARASASFPDVFIISSPYQDGEYLLIENRQAVLSDELLWEPGGIVIYHVDENMQGYGNRYRGGPFLEGWPGNGDHYKVAVLQADTKYELEMALNLGHNADFWKGGDSLGPGNGELVATDEGTYPNTDSYVGGNIRVTGLILDNFEETEPDVWSFRVQNLADPPITDTPTRVPSQTTNAPTGPQPSTVPSLSPTRISNAPDMSVSDSPTRVSAQATNAPTSSWPSTEPSLSLTRISNAPSILPKTTPNNTGTPSESPSASSSFKSILSFMPSESPSTMPTIASFSDLNPTVEIPNDDSSSQSISKGVVYITTCVCSFGYWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FLY8</accession>
    <name>A0AAD2FLY8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS8560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001113">
        <property type="protein sequence ID" value="CAJ1943675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FLY8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1943675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="175" mass="19419" checksum="22E44A3917A64FA6" modified="2024-05-29" version="1">MISQPKVVVLPVTDQVIQRVEAWAAAEGVMDNSMILMTTKRFELLADADNDVDDMPELTVRFQGDDDYESDDDDSGDEGDEEEEPIVADLNHHQENVDRGTDDIGSLVTDLEDRQEPPEEEIVFEPEEPQVAKVTQSGQTYAQAAMSGLNLSQVPKKPREWPSSRSGSSANKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FP58</accession>
    <name>A0AAD2FP58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS11375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FP58"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="115"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="580"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="680"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="751"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1947921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="816" mass="91828" checksum="6EB3864DD53D3D64" modified="2024-05-29" version="1">MVRASSAGGVSTGTGTKVDVTLKLSQLQNLCKRDPKGYREDYDAQIRRLESECGILKLSPQTPSPRLIELIQFAAAVSSSSYKGAESDRIANMLIELLVGGTETKSEQDKANLFMTMPASALQLARDVRKSCVSALILMRNKGVIPPLKLLELFFRLMAVVPDKGLREQLYKHLVNDIRNINKKGKRDEKVNRAIQSFLHRVVSTHVGEKGQGDEAAATDVAAKKATDMVCELYRKNVWTDDRTVAILASAVESKIPNVMRRSMIFFLNIEERMAEDQKEKEDDEWDASQKVNMHLFSRKTKTRQRHVQRQLKNRTKEQKKREGDTDEWLDIRDDPGVEACRKLYPAIELLRDPQGLAESVFKRLKKPRSVNYRDKLLMMNFLTRLVGNHELILLSLYPFLQKYMSGTQRDVTAILAYTVQGCHENVPPEEIHGILKTIAHNFITERCSEEQMAVGINSVRAICARVPSVLSLEDNTDGGEVSAEFDVEAFARDIAAYSNHRDRSVGIAGKGFMNFIRETHPSLLQGKHRGLKGSALHKNKVKPMRYGEQKVSGGVEGADLLAEYESKKAAHKKNGGGDSDDENDSDDESEEGDWKEVTGDDEEEVAMKFDDDEAVSDDEEAPELIVHEKSDETADESVIDLANMTAEEREKLKQEVSSNRIFSTADFIKMRKLVEREKKLKSDPREAARRKRAVARGKDFEELSDDSSVDSDDDQVHIKGAVNPYEIMAEAKRKRQSKAEKLEKILAGRNTFETTERAGGSTNTEKARKKNFLMSKSSRGARSKGRGKGGLNIKRGNPTMKQQTGHEAKKRRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FPY3</accession>
    <name>A0AAD2FPY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS11802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001757">
        <property type="protein sequence ID" value="CAJ1948831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FPY3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1948831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="240" mass="27031" checksum="B84868D984E301BE" modified="2024-05-29" version="1">MVAELGQYFHAIGTDSNNSMEPQSIKAIYIKPTKGQCPGHQVLNLNTKKMISRPKVVVLPVTDQVIQPVEAWAAAKGVTSMKFFDKKRDLETFQDGDQITGVDDTEQGYLEEAFDQDYEPEDEDERDFNLRGQFDDIDDSKREELLADADNDVDDMPELTVRFQGDDDYESDDDSGDEGDEEEEPIVADLEHHQEIVNRGTDDIGSLVTDLEDIQEPPEEEIGFEPEEPQVAKVTRSGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FQ70</accession>
    <name>A0AAD2FQ70_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CYCCA115_LOCUS11969</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001758">
        <property type="protein sequence ID" value="CAJ1949187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FQ70"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000122">
        <property type="entry name" value="Splicing factor U2AF small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="195"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ1949187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="267" mass="31430" checksum="3C0E43C7A7EBE559" modified="2024-05-29" version="1">MAKHLARIHGTEEDKVNCPFYFKIGACRHADRCSRLHHRPAFSPTILIKHVYRHPVRLAELKQAATAGEAIVDREKALEEFLCFYEDMFLELSKYGPIEALHVCDNLGDHMIGHVYCKFMEEEDAADALQAMNGRFYDGRKMEVEFSPVTDFREARCRDFDEGSCARGGYCNFLHVKPLPMCLIRSLEDDAQYDRRRVDDERRDKEREEKRARKKEKRKRRDGRDRDRDDRRRSRKSRRSRSGSRSRTRSRSRSRSRSRSGSYSGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FS55</accession>
    <name>A0AAD2FS55_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS12992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FS55"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1951274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="694" mass="77333" checksum="83C0BAF73783F4FD" modified="2024-05-29" version="1">MASSSSVTTNRNFNVFSNAKLPWWQTALVSVLAGAGAVSVGLLVKYRNSIKKRLRQLEQRLEQGLVYRDTSPASQHIRCLELEEDFLKQYGKEYPMMSMGQYLSQLRVTQDGEDNVQQEIPAILQKELEAVLGGYLLSKLGPRIGPAMLPLLGITKVDSWLTAVAGTMASWVAARLLIQDIKANQQSSSYDVAAAFPFTVGEMVSVTNINQKMAHYGSSEITPLDKLRQGEVGYSIRFDESVTNVGHTRQEESSSEERLDTKAECESDSGEERNESMVPNPFLLEEHLETAIQNMEARIRSNNNKDSAIYDPDNASFPPPVPFNERLLPDLYLGWGQATCTHTQREILLNRIIAVLLNKLSYNYYLVETFKTNNLSVRNGELLSNTLFAVDVSGITCHFPDEFVQALLKTGHQIEVCPRSTVTTFGLAACVKEKDGSFTGIPLGVFMRAGFEAENGDPLLFLGNHGGLDLSIRGPLVEKAVQGHHLEGQSAKCDIQFYVSIDGLCGWNSNHYPVVPWQRLEATSEVYNFQESLKAVRTTGILAVAFNSIATEMDLPFGGYGILGVCNDSAALVDMAVRGATNLYPLISTERYMWHTLRRLVRMQTNLQEQLQGKMCASSPMKPSEQLLEDVAILIHATSTMDSDIHSKPSRLFDALRRYDACYPRSIFQLTAKTKVMLQKEKLKYRQYTLAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FSS2</accession>
    <name>A0AAD2FSS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001792">
        <property type="protein sequence ID" value="CAJ1951994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FSS2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="571"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1951994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="811" mass="89764" checksum="81A1E90EC9C21744" modified="2024-05-29" version="1">MSKQVFTPLFIQIIFITSCLPFLGQAFVPNYSKNVIAKQASMDAPIGRDIVIQRNSNVIGITSSSSRTTKSLSSSLPGSFATKFEELQSLESRLEVLERSAPSALTSFYEPGLKSFSIKPGSVDRMSITSTCYALTAVLAANEESLYDSEINLDLSPFVDDDEDEENSGDKIQARAVVQELLKAEWRVDDLFQVPLLLNTILKVDASRSVIGEDIQKDLAPKVRELVEAVLEARPQRRAGANQQYSDYIGYLCCQAYATLYESTEVPSAPDSDLLNKKAGLGGLPTKVIPKGAASRLSLALTRSAEISFNELCRQLAYRAADERSSFDVIRLAYSLLSYVTASNSLAGTAGRELVPGEGPSPGSRVSLPNRKLIKAALDAFFSEQKDDGLWDKGQPIYKSFRRSGRNVGNAFVFAADTLGCLLSKLPAESFRPHLDKLEKTLQWIESHQLVEVIPDYCDAESGQCYGKALRGWSSPHLTEDTGPLSWSTAQTLRCVSEMRRVVRALQNVDVLAEFKGLKNMEKTPQMAAWDRLLDTDLGAVGPKTRTLKEVLEERVIVPFEYSSSNPGFGAAYSVILFGPPGTAKTTICEALAERMGWDFLVIDTTAFLADGLTNVASRIRYVFERLQSLERCVILFDEIEEFCLDRETPGLGMESRMLTTAMLTAINDLRRAKRSVFFLATNRLRAFDSAVIRPGRFDMQLFVGTPNLEAKVLQLRTKMASMPISKETKKRTEEKFRSFLESAWEKDAMFMNYLEGIQFATTCANIVATQGEEGLTEEAMSVILDTQAAVMTARGAVREEYLASMDMSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUF3</accession>
    <name>A0AAD2FUF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS13575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001803">
        <property type="protein sequence ID" value="CAJ1952482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUF3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1952482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="614" mass="68378" checksum="7E6DBBAE05C816B7" modified="2024-05-29" version="1">MINAHQLLAKRFAHPRYLAVIRALSTQVNHLARYQKMNWETFLSTGRGSDNLFRSIDTNHTDNITPSELHVFLDSVGHKGVHPRAFKMLNELAHDHNLSRKEFKSWLVLATNFQQEQESQYALSYERHPHTGQRKPQLDEDNFHTWNEHTMSQAVRKMQYAVRGQVVMRADELKAEGKDILYTNIGNPQAVGQSPITYYRQVMALCDLPEEDGVDHPNVYEMFPADVVNRALEFRKTIGPAGTGAYTGSQGILQFRHDVADFITERDGHPAYAGNIFLTNGASSAIELVLTSIISSELDGIMIPIPQYPIYSALIAKLAGRQVGYFLDENSNWAATESELTQRLQEAQANGIDVKALAIINPGNPTGQVYSREDLEVICKFCSDNGIVLLADEVYQRNVYSPSKSFLSAKKVALETPGCEYLQLVSFHSTSKGVIGECGRRGGYMELHNIDKTVQAQLYKLASSGLCSNVPGQITTSLMVKPPKRGDVSYDRFQKEENNIFNGMKNRAKALVESLNKVDGISCNPAEGAMYAFPSIELPPKAIAAADEQHVSPDTLYALSLLEETGICVVPASGFGQKEGRFGFRTTFLPPDDKMLSAVDKFKSHHENFCAKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FUM0</accession>
    <name>A0AAD2FUM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS14486</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="CAKOGP040001847">
        <property type="protein sequence ID" value="CAJ1953889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FUM0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042102725" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="162"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1953889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="248" mass="26565" checksum="0252E8690C9FF65B" modified="2024-05-29" version="1">MKVSKVTMALISLLSTRAGAFTSVARRSAVSTTARFMSGPMPYDDDKMPFYALGTNLALQVGGQGNFKTLLDDKELEIVLEAFCENLRGTNAQDPRAVLTTYGQELNKILGERTAGIVERVKKDGDDYIKNFLDCNDEAVQTASGLVYYPMVEGTGASPTLSNQVEVHYHGTLTDGTVFDSSVERGQTISFALGGVIKGWQEGLAMMKEGGKATLVIPSDLAYGDGGSGDAIPPGATLKFEVELFKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FV88</accession>
    <name>A0AAD2FV88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS14711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FV88"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1954116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52238" checksum="DE081DA147F1DE4F" modified="2024-05-29" version="1">MSSNDNVFDRTAAVHDETHSRSIYDYKQLSDGQQKLLAILPIFSALLTIFGSWIIILMAFKSRRNKPWTPYHGLLVAMSLFEILGSFTSAAGPFLYSKQTSDRIWALGTSGTCTAIGFFNQFGSHSAMLYNGTLSIYFLLTARFNFSNSEIASRYEALMHYLCIGYPLITAFVGLFLNVYGERSTTIGCWVARCKIDTFTGEAICEERGLIEGFFGRYPVVATLAMLIFGNLLIWIHLRRQLNKRRKQKMAAGANMDEDSDSDSDNSTEDEEDSNQSGGNTRPKKDVITAGQRRALRLVSSQAFLFVGSFMLCNTVTFVLRHIIPANMNGDPVENYIAEMEIPYNNFALMVIQAILFPLQGLLNMMIYIRPKYKNNRLYHCEETRVWAIRRAIFGEAVAPTISGDDVDRNSVASVMSIGSPKMLASQGSRKRPVEKQPSKDDLGETSNHSRTQPLDCQRGSSSSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FVG6</accession>
    <name>A0AAD2FVG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001858">
        <property type="protein sequence ID" value="CAJ1954179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FVG6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="121" mass="13458" checksum="6535BA2D33687E07" modified="2024-05-29" version="1">MNDAGMLTLHKDFLEIYINMAPHVGEAYVMDNAKVLVLLSKFIVGNTEAEATLQANNIAGNGREAFNALRTHFEGKGILASDIVEAEHTIKELCCVGEKPKMNWSMIERMLKKSVCSMRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWC0</accession>
    <name>A0AAD2FWC0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS15309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWC0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1954717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="393" mass="42564" checksum="38546A85678FA2D5" modified="2024-05-29" version="1">MIIQTGQHNHINLASSASSTLPPPPPPIATSTSTSLQNRQNSRIPNSSIPSLGRQLKRLRDSNTSNQAQAAVLALQPIVHNWMQTDSKQKASAVAQGSSSVNTNDTFPDALDFGNTTTSKGIPGNTPHHSSIPPSTFRADTGTPSSFSSSTNAGEHFQQLRGVPILVLAFKEWESCSVVVSTILRILANLLHREATIAHALVEMGGLRTIVRAISKQHESKNETVFTACVALLSELAQHMPSTAGSDACLALVVHSLWRFPTNGYLQGFGCLFMERVLLPKLLLWGVSKPTTKPLPPPSGGTTIEGDSPGNNEEVVEEEDAWSITTIHQEDTLQKVVVPLLIRMTKYHHGSNPALCQTAEHLFHCINERLNNNNNNNGVEFVPTTSDQWSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWC2</accession>
    <name>A0AAD2FWC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWC2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="226"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1954541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="422" mass="47261" checksum="128ABBE38B042F02" modified="2024-05-29" version="1">MPDDSMAVDTPETPAPAPKDKDKKKGGGQPSASEESAAPYPDMEFAQEIHRLTVKSAGVDAEYQTKVFKKIIEELENPSFYRLLQTTLSVDTGLCSKEKLKEMDEKNAAHMKELEAKVEEAKESAGDMEVMDARVKIARFAAKSLTKDEALEAYKKLLELPKVSSGKKIDALMESSRVASFYGDTDKSTEFVESAQKLATDGGGGDWDRRNRLKVYRGLGRLLERDIKEGASLMLDCIATFSCNEMCSYPSFIVYATLSNLLHIPRPMIKEKILDGPEILSVANEIPDVIKLVRALYDCDYKAYLNAMVEVEPTLVADRYLQPHVAYWMRELHIMAHKQFLDSYQSVTLQAMADAFGVSTDFIDYHASQFIAAGRLSAKIDKYGGVIITNRPDLKNAQYREMIQKGDLLLNRIQKLARVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWH1</accession>
    <name>A0AAD2FWH1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWH1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="124" mass="14135" checksum="CD358DAC28A0E921" modified="2024-05-29" version="1">MMRSFALRQMTMAFGRIPNTPGSISLITSRHLSSQGVAAVENLRDALEEYRKEHYRQCLPSRFKKDLVKAATNRESGRIAIDDLQQVIANISMEHKISEQEMETIFQELGESGKISADKFMKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWM3</accession>
    <name>A0AAD2FWM3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS15474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FWM3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1954882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="546" mass="63020" checksum="1EE1AAD78C9B6F79" modified="2024-05-29" version="1">MADAFNDTQLRTLAIIPHITGIISTIASCYVLQDILRDPKKRTRTYCRLVFGMAAIDFLTSLMYAFSTLPMERDEAPYGVYALGNHATCSTQAFLIQMEIASPIYHFYLAWYYLLILKYRWPERKFRGYEKYLHGFALVFALATSIILLPLGVYGEFFVWCWITNVEGNGYYQWFFFFGPLWFIILASSVVMYQMCVHVKAEETVSRRWRNSIVDTSKLGEKKLKKMTSRVFWQAMHYELAFYATWTIPTISQTLLQLANVKPSFGMQLANAIFTPLAGFFNFTIYVRPRYIKYMEDNKKEMWWYILWKAIKHSVPSRKMKVEIVSVNFDDDDDDENEDFDPTNRKDDDNDLGGGNHTNRIDDDDDVICGNDENETENNNKKRKGRKNNQLPTPDTKAYGIDMSGSIREQSINHEELKHKKEERKTEEGEPDYGYEDPDAPSSIINMHPSGSMRRQNSHSIMVMDYEEDDVGVMDPALALERLFNVDTKLKMMSLPKKGGKKVYKLVKKVNKGVKKRRRSLMGSVSSLLGLENPPSGSLKGDDNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FWX4</accession>
    <name>A0AAD2FWX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068">
        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068:SF14">
        <property type="entry name" value="CELL WALL ADHESIN EAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042286539" description="VWFD domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="758"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1423" mass="153766" checksum="8A5868C66A0C9B41" modified="2024-05-29" version="1">MKLLMRLALMASTANYVVAAPKANLGLCFAQEACIDFTVKKAEGTNCTSADGCGIEVCMILDTTKEGCAKDGPISHLCAASDSQGCAAYDTDGVTPLTGKGGSDFCDLSGENATLAFSGKCEPSETQTKITMCQEAAPGQTLYWALKDASVEDVNVYDYTSNFSFEVGSETCSSPKISCFGDSELQCADPKNDMYKYTRVWSFEIPASDGSACDLCDSGEPEPVDPEAWVWLSCGSPERCGTFNEYKVQAKETAELRCCSSDPIDGWKKNSGCDIWTESDLIGADGSVQCFHESTYAEAQQICADNGGYVCSKEEVESGCVRGSGCGHDNDLIWTSTTTTEREPIVFPNTDPVDPEDWLWLSCGKGEHLCGIGKDIAVQAKEAHELRCCSPVPVSGWKRNSAECDVWHESDLLGLDDRLRCFHDVTYADAQAICAHNGGHVCTKAQVDSGCVKGSGCGHDGDLIWTGAVAPEQELPPLPGQDPVDIEEWLYLSCGRGGDLCGFTGDISAQAKEVHPFRCCSDYPLEGWMRSNSCENWHESNVIALDGTADTCFHESTYAEAQEICKFNGGYVCSKDQVRGGCARGSGCGHDADLIWTSTGPAPPRQDPPAPTRVADDTHLFLACGSGMDGCGGGEESIGVAKANELHEVRCCSNVPLPGWKKGSGCTNYHESDLTALDGTPDQCFHASTYAEAQDICHANRAYVCSMIEVLDKCAKGSGCGHDNDLIWTSTAATDEAIEAYKLRKTQAAAISGVCVGPKGRISGDPHFTTFDNMRYDCQGHGEFVIAMSKGSDPLAIHGRFVPVRESKAKPTVTRSVAIKVVDEVPIIQVTAPQEKIDGNCPFTFTMGREETLIPTEEIVSFFTENYNGTVTVFSNGKNIIFSYPEVGTRVQITAGGGGNRCVLNTNLCLTPENHGGAENIVGLLGSPDGNKDNDFMARDGSVVPPPAICDIPDATNSEAKLCKRAKNQQGHEWCMDNWCIGHADNSLWGEESHAEYNQCDDRQPDEFFDNDDVDPAIVEACEDAEDPDGCVLDTQIAVEEGEDVFDFVDTVLEEDDEANFVDNLGGDPTEAMDGWDGPVLSSASAIEIDLPDPSDPSDPSDPSDPSDPSDPSDPSDPSDPSDPSDPSDPSDPSDPNLGTDENDGTSPTDTADISTTDEEPVSESSGSLGDPHFKTWLGEHFEYHGQCDMILTKDKNFADGIGLEVQIRTKLVRFWSYIKQAAIRIGDDILEVEGNSDPEDTDTHYWVNFEYAHEVKSIGGFPLTISYNGANKRVFEIDLSSKFPGQKIVISTFREFIRVDFQHTTAEAFGNAVGMMGDFKTGSLLARDGVKEIDDFLEFGNEWQLLPADDMLFHDKAEPQFPKRCVVPEDPQGQRRRRLGESTITVEEAEAACAKVVGDALDIKDCVYDILATQDMDMVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FX86</accession>
    <name>A0AAD2FX86_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS15905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FX86"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="4">
        <location>
            <begin position="37"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1955749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="445" mass="47719" checksum="1CDB76BF9E977430" modified="2024-05-29" version="1">MMNTTIYSGDIINNTTTEKKNNNNNNDDDDNDQKSSFVVLGDAFADLVCHLDGPFPKEAGGDTRLEHPITTMAGGSGLNTCTHLCSLVSAAELLGRQTVSLYTAVNESDPYGMLLCNHAQEQGFDLHNCHPDASNSSTGHCAVLVANGERSFLTHLGVMETFEARHIDTGRLTLSSSNQKMLFVHVAGYYNIPGFWDGALKRTLQTIIQTKMKEGGGGGGGGDNKNLVTSLLCQYDATEAWDGQLMDLLPLIDYLFCNEVEVEKIAQATTMKSQSQESPSSLSSSQQHQQVESSCMEDLDSDDESYWIDMARFFQTTSPSTCVIVTLGPKGALALYGGQILARQEAPTSVENPLDPTGAGDAFISGFLYGLFVVPVAAAATADSLLEDSDTATATASKVVPSRKESVQQALQYGCAVGTSCISRMGASNPAPRGEIDELMKKYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXJ4</accession>
    <name>A0AAD2FXJ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Chromatin-remodeling complex ATPase chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CYCCA115_LOCUS14920</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="12">
        <location>
            <begin position="24"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="326"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="628"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="12">
        <location>
            <begin position="1328"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="24"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="1328"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="957"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1261"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1394"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1175"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1287"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1315"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1426"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAJ1954328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1442" mass="166416" checksum="E415DD46242BA3F5" modified="2024-05-29" version="1">MPKEDRSDWVAVAPEFAASIGDKIKPVTSAYQYFQKDISEQVKAELGKGFKVYEFGRAVKEKWNNLDDDEREHYEQLCREDKARFARESHAADIAAIERRERLQRERDMLMLDDEGGVRRTTRGVRAKKERKKARKDKRGNQRHSKTDRNMADNQEFVDDDDDESSDSYSAASDSDSEGDSDGNGRPKKKKAVKPKPQMSEKQIEYRRKIKEEKQQKEQIIAARQEDVRKEKASQAKRRLEFLLKQSNIFSHFGQVKQDTAKYGIKTAVATKNSDDTASSRRDAGDDDDDLEEADESRATFLTAQPTTIGFGKMRQYQLEGLNWMVRLQENGVNGILADEMGLGKTLQSISVLVYMLEYQNSTGPHLIVVPKSTLSNWMNEIKRWAPTLSAVKFHGDKTAREELANNVLCPGQHDSERTWNVCVTTYEVCNIDKNVLNKFAWSYLIIDEAHRLKNEASTFSVTIRTFETRYRLLLTGTPLQNSLHELWALLNFLVPDVFANAEQFDEWFNLDIEDNDEKNKLISQLHKILRPFMLRRLKKEVEKSLPPKHETILYTGMSAMQKKLYRDILIRDIDAVQGTTGNRTAILNIVMQLRKCAGHPYLFPGVEDRTLPPLGEHLVENCGKMVLLDKLLKRLHERGHRVLLFTQMTRILDIMEDYLVMRRFKYCRIDGNTTYEVREDYIDAFNKPDSEKFIFLLSTRAGGLGINLQTADVVILYDSDWNPQADLQAQDRAHRIGQKREVQVFRFVTEHTVEEKIVERAQQKLKLDAMVVQQGRLKEKDKLSRDELLEAVRFGADKIFKSKDSSITDADIDMILDAGKRKTQELNEKLKAADKGDLLDFKLDGNSNLQTFEGVDYSSNVLAQARKEAELLHIIDMGKRERRTVANYNENKLYQEQMAAMQGKKVERKRKIIKLPKEKRLPRMEEWQMFKRDRLIAIQEQEEAKFRSLPEEVQKLEASSNKASDPVDSSTGASATNGDGNGAEGKEEGSKPTPPLEVPPLLDEETQAEKDKLLSEGFATWRRPHYSAFVKASGRYGRSNYAQIAADVGKSEAEVKEYADAFWGPVGKERFSEHEYDRVVKLIEKGEKKILEIASLERCTKVLVSLFENPWEELEYQHVTTKDKLFSADNDRFLLCWAHKFGYGQWGAVKMAIRRSPKFRFDYFMRSLPMDVLGRRCEHLMRAAEKEVEHLEKNAREEAGLPVEAPEGGALPPVQLPSFKEMQRIFRQRKREQTEQEKIQLERKVEELETEMKNIQDRLKELNSSGVMEVQQKTPSKTMASRKRPRSSETTKEEEVSGPNDIDESKGTIGPEGEFLEFPEYDGVDPPKEPKKAFTHFCVSTRKTVKAALDPTERKNKEKIHEILREKWMNLPDEEKLSWRKWATWDKKRFARDMDIHESKKKNGTPKADDENSESISAEHDLQVTKKKIPSLHVPKKKRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXM8</accession>
    <name>A0AAD2FXM8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXM8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="128" mass="13789" checksum="0672DEA1C1913A17" modified="2024-05-29" version="1">MTSKTLDSYSMLSCPATDALRTVQATKVGRKGRASGFDVMLSSSLLDLTFVDASVDSFPSIEWDSDDDFDSNSSLRSLDTLISDDSSLSSLGKRSRSDSRSSRRLVRSRKIKSGLASLALPLPISTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FXS0</accession>
    <name>A0AAD2FXS0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS16259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001914">
        <property type="protein sequence ID" value="CAJ1956489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FXS0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1956489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="379" mass="39317" checksum="0F2BB4C8F9515B25" modified="2024-05-29" version="1">MKLSFAAGMLIPAFAQGDDERPRVEEACSKDVETLCSQGVLLEIERRLNGADSEDNPSQAPLPFEPKQNACLLGSLSEASTECVTAIRENEFMYKLDLLKHRESHCKVTFIVFCSVVIFFAVAFWAKFAKKPRSNSACSGSCCSKSKEDKNDTKCCDGACDCCDEEACCKNPNATDCSCCCCCSDKTAKTSECCGGGCCCCGDDCKCSEGKGCCCGNGDCKCCKGALKTSEGKCGCCCCGKDGCKCCKGTSGETEKCCDVVRRPSVVAVVAAAAAETTVSALKESAAAAAEKTSASAARVLLARRAESAVMVHAIAVMKMPAARIPTQLIALAAAAVARLPISPSAVAVVAAAAETTASALKARDAAAEMMTASVARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYI1</accession>
    <name>A0AAD2FYI1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001892">
        <property type="protein sequence ID" value="CAJ1955507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FYI1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042152122" description="SET domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="83"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1955507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="447" mass="51834" checksum="7D35F36481212655" modified="2024-05-29" version="1">MMSLRFLPLFILYFISFLSNAIVAKEDKNNAEAIRSTKRNTLNLNVHDNRRPRDDHVIDNAKQDEAVRNMVKWSIEQGGYIHPYVEIRRWDPSDPSSYFGAFVNGPVKKDELLIKIPGSIEIQIDDFFRMGKLPYSDVVCELAWTLKREYELGEDSKFAPYIEYIKTQSKYQIPAMWTDVGKSLITKVQGDLSMMDFDLEDTPGEHMHNWIYEYFGGELCLLDADNEEEMEEWYVAMATQRGYDYCLIPIYDMLNHSNERVNSITRPSIYNRDGFGVYALEDLNAGDEILYSYYDCPDCKGCPTCGTSLEYWGTPEMIRDFGFVEPYPHRFYYDDMGPVYLRVDEHPDGLEISNEGGEWPEIEWIESQIARLKPMFERDIYPLRNVLPSHELETIVNYHGSLLDFFTAYQEVDAADSKDENHGESDTGRDEDLSDGGEGDAPHCRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FYT9</accession>
    <name>A0AAD2FYT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CYCCA115_LOCUS15477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040001870">
        <property type="protein sequence ID" value="CAJ1954885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="455"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="1075"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1503"/>
            <end position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ1954885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1531" mass="175553" checksum="0F90C6C63CB976F8" modified="2024-05-29" version="1">MYGLAFEALEAWVLDEHGVDTWHATKKKARCNAEDKGFVSRTSYEYKLFVRLLKSLSLYLEKPADKILRNFGNYIVGYLFASEYGSILRSQGSTMQQWLANINTSIDHFQRSFPKEKDQSSSPVFWCEERKEEEGSILLHHYNPRGNAFVPFVVGFLEELATFHFDIDIKMELLNLQNSGDAKYSTWMIKAADPTHNWKITPSVPKETSNMDRLLGLTDNDLPVVGCPFVENDGNHAVTTRPTTEPRSNIGSNEALTVNRLRQVFPFHVVVDRDFTVVQVGSKLPVVLKTSPSELCGTHIRELFEVLRPKMAFGWDWNVLDKLWDQTFLMKPITDGLQSVHEDTDILFNSSLLTLSTQLVMFSLRPNMREIDNLKRRGLTLSDMSNVTSERDAVFLGEYVSREAGKTLALERLSRDLRAEQKLSETLLYNLLPKNVARDLRNGKTVEPRYYEHVTLFFSDVEGFTSLCDQIQPWDVIDMMNQLYSVMDFLAKHFKLYKVETVGDAYVCASGLPEEDESHGERIANFALAVLECTKHVKSPLTGEAVKLRIGIHTGSCTAGVVGTLTPHYCLFGDMVNFTARHETSGTPGRIHCSNDLHELLKSRSPAGAQQYRFKPRGLVDMKGKGEYLTHWLERGTENNYAANPGSLLTLSNKVRKRISSKKWKMRKYFQKQQPQKSSRSLDLSIHSGDPSCMSSVASEGTNSITLNSRTSFNDNDNQEQKGAEIQHENILNYSEELPKDAQEWRELHFDIFLPEDDLVSEIFGILFSKLNKCIEKGGRRLKIIKDQLRSYVQAIVDLYNSDSVYHSLRYAAEAMNRAAFLMDRRSEVEKKDPWDVFMMVFAIFVRDIHHLDISDDQLEHERHYLVSHYRGKGAYQQRRSLDAALEILEDDFQQLYDEIFLGCPTFRRGVKKLAVASAEIESESRLKGMLSRFDSHQDKPSARVRTVQHESDDVLAMFLALATMGHYCQSHDLFLHWNQLQLMSQLHCFENDKRSTDPCKSWHKEQTLIFKNTIEPIVARVEKLLPQNSWLRFGFTNNLSLWERDGREWVSSSLIPEARVTAAPWAHNSDMISSNLSILETLLAEIAASRGEDGTVGEVDWESLKKTRTPYEEMRLSLDVGRVDNRVRIDPLNHDDLPARVQEELRDFMLAISNGHGRNEFHNFHHASHAAHIADLLLQSLETESDENRKITFDPLVRFAVVLSALVHDVGHTGVPNSRLKVENPELAAKYSNKSIAEQNAIDMTWRIFMSDDFQNLREFMFGSSVADCKKLRDLMVNGILATDLENPVLKALRKRRWFKASTCKFTKATLIMEHILQISTVSHSIQVWEIFLEWNEKQFWESYLAFLEERSKKDPSETWYEDQLKFFDDFVLPLTETGTETGVWDILGDQLFQQATRNRLKWELEGRSICDSLIQKTKARFSKPSDATASTAAESILTSTIVEQIESLSKVIKRYERKAETACGNLITVAYNDHSSQATKGLRTKSWSEIHQHFKQQGWYRVHSKTTDDDDDRPEMYSRPVKDGTVVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZ85</accession>
    <name>A0AAD2FZ85_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calmodulin-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001951">
        <property type="protein sequence ID" value="CAJ1957723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZ85"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1957723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29481" checksum="3A5CC167DC8C7F17" modified="2024-05-29" version="1" fragment="single">NDDGDTVDDGTYALPWQSGKELSKLWDEIIPCFEGGRMPKRIMELGSGALGLVGLSFCVSLQEGLLEAKSTVLLTDVPSAMPLLQHNLEHNQSLLPDGLVVNAKPLPWAMDRPDDDNHEAKTNEPPYDCILGSDLLYNEKFIPHLVATTKRLLHPIRGIFILAVRWRKPDLEREFFQESGLVWELIQPTSGALSCPLDWRAFGDPKNEKSNLYFHQTQISVKGKPKALADITEEESGKLLADEFKAWDRAHIQIYIGRQPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2FZS3</accession>
    <name>A0AAD2FZS3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2FZS3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009773">
        <property type="term" value="P:photosynthetic electron transport in photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009644">
        <property type="term" value="P:response to high light intensity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037497">
        <property type="entry name" value="PGR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35709">
        <property type="entry name" value="PROTEIN PROTON GRADIENT REGULATION 5, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35709:SF1">
        <property type="entry name" value="PROTEIN PROTON GRADIENT REGULATION 5, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042101308" evidence="1">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1958496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="129" mass="13665" checksum="15E83A4E9950FE60" modified="2024-05-29" version="1">MKTFQKIAFLLIVALSAVNAFTSVSSTSGSNFVVSQRSRAAQATACPARSGVSSLHMGGKQSKFGIFSPAVYGAKIVLGNDKLLKLRGQAISLHSQAIGEFCLWAGAYHLRTKLIKMAKTNGDTLGFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1R5</accession>
    <name>A0AAD2G1R5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS18285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002025">
        <property type="protein sequence ID" value="CAJ1959866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1R5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="746"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="644"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="753"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1959866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="776" mass="84646" checksum="E4010F458E9D4091" modified="2024-05-29" version="1">MILIGNASACNPCSNNGPQEAQQKQQKQQQQQEALPEELTCSICKELVQAAVLIDKCRHSFCSFCIRLDFSAQSKKLKSKVCCPWCRAEIYPRGVNKADQHLTANLELQEQVFHFKQQQSLLSSQSRQQSQAKKEVDESSLPSPLRRSTRHSNSPPKQQPQPPSQESQVSLYSKRNPPLPKMRAVHYQGKKRKDLIALLRPYGLPCAGTEDELKNRHTRFVTYWNSCCDEQVDPPSEATVIQQFRSSEVKKASATAAGNSITLMMASSSNGNSSGSSGSGRVNSINAADDRARLLQEHAEGFRAIHEKILEDSCDQWCNASFRLAIAVLQSHPMIQNDSFRDCLRQRAMNENHQEIPIQDLLSGEVPIPTTIFENIDHERIKRNSPSVPTNMPTAKRPRIEAPATPVGAPISNPYSKKRQSNSIHQPPTATARDAKLVNHAAPMLGSTALRNYSPSLPENPYRKSCNNTPSTATKSMSTVGSPAAATASLPSRSPPRNPYRKSVNNTPSTATKSMSTVGSPDTTTTSVPSRSPPRNPYRKSVNNTPSTATKSMSTVGSPAAATTSVPSRSPPRNPYRKSCNNTPSTATKSMSTVGSPAAATPVEAAKKEASTTTFKSISVPMSEPPPHKAIKAATTSVMRPNDASHQNSNHNNNNNNNIQQNNSNASKSNSKPSPSTAISQNDASQPRNAVSPPTVATSFFTKKTTRPKSKWEWTCQVCMYEMKLDPRATKCACCGKPKGATLEDAFSEHHQNSISQTQQTQSSSAGSQNDPIEMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G1X9</accession>
    <name>A0AAD2G1X9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002036">
        <property type="protein sequence ID" value="CAJ1959948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G1X9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
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        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="553"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="599" mass="64520" checksum="D44801EC38ECA803" modified="2024-05-29" version="1">MAATTTVKTNAVWSFGLGGLEGEDSEEESEAFGAFQVVQKEGEDKGEDKEEGETEEKDEKEEDPEPTEETELDSGSDAASATTSKGSLDLEEEKPASAVWSFGLGGQEEDDEDDEDSEPFSFTPIGDVVQEEEEEENIPEEGPAPVTPNRQPIQQEQSLEFSQLQSHSPTSPSAAFTINEDSAVNDETLVFVSPVSPPKRPLSVGSLRRPRYSSNLDPQVRMTPGTLLSKMTPSGAFKKASLLANLSVKGKQDKRLNRGNRISSIQSSFRHLDLMSDSDSSGLNHIPDADDTDKIPGNESMNTGATMTSSSSFQQNDEDSELMNVLPVLPNMHDDSSSNFDESSRRTNFDESQRSAAPLLQGNDDDDDNDDDNENASSPGTKKKKKKSSSKSKSPKTSRKTKKIKGLAGDGDDDDVTTTTTTTKKKKKKGIKKAIQMATAPAVAMTELVRDASSDVKDLVTNTATGTKNLVNRTSTGAKDLVTSTATGAKDLVTNAGEQLGFTSPTPKKKKKKSSSNKSGDDDNNTVTTKKSSKSSSKSKTKSPKSSSSPTLPIKKKKSKRKIVDPSKEIQRATERPSLEVKQSSFSSNHSAQSCASFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2H5</accession>
    <name>A0AAD2G2H5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002047">
        <property type="protein sequence ID" value="CAJ1960175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2H5"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="659" mass="74316" checksum="6754A47F9AE6B83A" modified="2024-05-29" version="1">MVDRTRVTLYQTESNLGNYQTTSISKLYALNNNILAGFESHYQNGLLEVAFYLGLKFADSALIQIPKHGYFYSSKHKNERSQSSTDSIRVTQLLQQIVALEPERLAKECHKVERLHYLAREQFERLDTYEKKRAAVERDLYHQQRKGGSHRGKASSLNKTPKHRKSRSRLSSDQDCMSSTLLACGDSFSSIFCPSVASSTSEAAMAIREEFTGKKKKEELNKSFPDAHKIRPEKGSSKSTRFPDGGKREGISSFPTNPGVSKRSFPSDAAIAQPGLFPASPAKPVLERKESDYIPPPPPEHHRTQSDLDLERALFLSGLQVLQDKKRAQNGGNFGQEDEVKLEILREELRDMPPVPVGPPGAKKRQASGVTTELFTNFMQQDFEQLYKKGRVRITQMSTYQGKNPLSTNGCAVIAPLMCIHHFVNESSIPDHGLPDRVVEEVLDDETPNLLPMIRRKLGLVDSAFLIPSDAHEALMQEDLLSEKQFRNVLGGNILDESHLIPLVEELSKIGEKKIGATFFFHEHVVSILQLRQDERTVWFDLIDTLPHEETLLRGPSKWASSRNHGDDSKISNDDSYRILSDFSDVDLAAGVVVDDVPDQEPAARIRCLDAEALRIALQWYACSVFSMEDATYIDTYQWDDNLADFDPRVFQAFIWSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G2T4</accession>
    <name>A0AAD2G2T4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G2T4"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="18369" checksum="A559498A4C61AFBD" modified="2024-05-29" version="1">MTEASRSDHSLLVYYAVGIAIGCIIAYSLPKNEGEIERLKAAAIKEEERETFGKVKSELDKGSSSWDGDSIPKEELERIRKRFRMTPQQMTRVVALSKAEGTQDPKYSSLTPHQQLNRMVYLVMIMVLIYILNRDYGNVVLVWFVQIFPKEAEILGLVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3D2</accession>
    <name>A0AAD2G3D2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Immune mapped protein 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002091">
        <property type="protein sequence ID" value="CAJ1961361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3D2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040955">
        <property type="entry name" value="IMP2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18590">
        <property type="entry name" value="IMP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immune mapped protein 2 N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1961361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="171" mass="18741" checksum="B5D977FDE142869B" modified="2024-05-29" version="1">MPEFATEEGPEGCYLMFDTLSGGRLLLYYSRGKIPLNAIGFWCPGPGKAIQGFKFKQSSQELIKGIAGGDQNRKKYFSGWCQFIKQAKAMGGYVIKFPNAEQGGVEVDIIGFRKESEEPIELDLEEGLIEVADLDAISVVPKHNPTFRGIKTIVESNFLDMGNLAGAAINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G3R8</accession>
    <name>A0AAD2G3R8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G3R8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="314" mass="34671" checksum="093F342660A520A9" modified="2024-05-29" version="1">MEAVSLDSLQAISTFASSCDDMYKDLRSRPSTTTIKSFRMDKDFEYSMKGMEKEVKQASPTRLSSNILSSSSAAPSLDIPSEETVDPIWGQRYETQPSLSSFSSSKRSHLQSNKKKGKGKTKLSKFGQYSAVVANNNKKKSSKKKMSMPLSELKLKEVQLISTLGKLRGNSPDKGVSVTFGDITPIVEKHSRKNVPIKNPAAEDSSDNESIDTSSSIGTSSTAESSQYDEELATVLSRIQLATTQPSVSYKFGDGLSDCDLVDEVVNIDVPGPEKEETKEFVQQPQADHLLAVQEESLRKAMERQRKKESSLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G437</accession>
    <name>A0AAD2G437_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002092">
        <property type="protein sequence ID" value="CAJ1962131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G437"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="802" mass="88927" checksum="00AEF21B08BBF588" modified="2024-05-29" version="1">MTFTDYDSDDDLVVTAASRDKDDVRKRSLNDNDSVDTVGEEFGFPKTPSSASKTTTTTTATSKQRSNTSLTGDILVDYYVTARRYLEQLSPKAKSIIGFVILLVASTYTLHGMDGPSASGKGPSAGARIPKTGAASSRNPFLPPIKLEPIPSGETCSDICVKRNTKRQEKYGGDLLNPQDVLRLAKDAREKSIANLKVDYGSYFEEIFMNVSSPYKYYGMRGANGDGPSRDRLKRKLKLKVLHMMQTLRGMEEDVAGCNCLGAATTGEPQGETAPVPPQFYEKYVFANGGHSQAAGHGNMFNETYTAYFTKDVKDVFGAIGIKFEGRNYGMGAMSASPYISICSKEIFGIDVDLLSWNFGMTDKWHDTSSFYMYRGALTPGRPALLYIEGNGQANHGGRGLEEEGLAVFKADMHSVPTVTRSANNKIPDSAPGGIRLSDEELEKLPPYLQALKCNGNLAGKPFCNGRKWSCTMEDIENGKQCACPKVGKRSSWHMGYRMHALLGHLISLSFMEIFIEALEEITTSSKESNTQALYEELRQAEDQEFEAFKAKPVFDKIAFNQSRYSEIYNNTELFETFFKGDSVCRTSLVPSQTRYLGISTNSDKVAPGPQPGWAETYDVGVPLHISAGKYTYDEGQEPIPGIVQQTAKIDLRVRSDEFRKYCSQIVMPDYKDWLYGPLKDGKTTMIFPNEKEKEYYGYDPSKFKGYLGLVPTLFGETAGKGVSSDISFNAFETNVRATVNGKKVGKFHMVNQMILLVDESGSYKWEPSENNDYVIEFEPYGEIDGIPAADKHFRLYGAVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G4A9</accession>
    <name>A0AAD2G4A9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002098">
        <property type="protein sequence ID" value="CAJ1962196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G4A9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="249" mass="28671" checksum="BCD456E6A70BC1D4" modified="2024-05-29" version="1">MSGLNLSQVPKKPREWPSSRSGSSANKNKNRVATRRKHQERELKPLKNKLKFGIRTKEGNRSTRDSKAILEAKHNLCVQQIRNEMKADYEEHNAFLIARCMMQIKAKFDTDEGRKIHRYLGMTLDFLVKGKLKILLEDFPIKFNKDSKQKTPAGNDLLEAGKGKLLSAEYPQIFCTTVARGLYVSKRARLDIHPKITILASRVRENQVEKGNVKIEYCPTDNMIADFMTKPLQGEKFRKFRDLILGPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G560</accession>
    <name>A0AAD2G560_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS19972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CAKOGP040002125">
        <property type="protein sequence ID" value="CAJ1963023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G560"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042020203" description="peptide-methionine (S)-S-oxide reductase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="6">
        <location>
            <begin position="104"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1963023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="317" mass="34185" checksum="920D5C723EAB0CD4" modified="2024-05-29" version="1">MTNFNRNGLIIIRNLALLLFCFLIGGSAAWSPAAASPKSIKRSLVTSSLSLASSSSDASSDRRGFLQQGAVAVAVGAVSITGLATNPNLADAADDEVEEKMMEVYFGCGCFWHVQHEFVEAERNILGRKDDMTLTARAGYAGGKAGAKDGKVCYHNALQISDYGSLGHAEVVRLQIPPSSFKAFCKEYFALFNEKGYRPDQWGDTGLEYRNVIGIPGGVGSTYAKELIQVSQENGDKLDFAKGKGDDPDARALCFVMDTADFPFYVAEQYHQFHDGFNWGENYPNSYNDLASKLSKANLLGESKCPNGLIGVGALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G5U9</accession>
    <name>A0AAD2G5U9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS19713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002106">
        <property type="protein sequence ID" value="CAJ1962491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G5U9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1962491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="184" mass="20550" checksum="DC9BB57A441AF35B" modified="2024-05-29" version="1">MAESEASDALASSSQFANKLKSPLRKGKRDDLDERQPIPAWKLRERMKNESRPVYKPRAVSRTPLRGNSSLDPSLPPAFQAAAAKQRKKEQDDFMSLDSVHSSKTQRSRLTNDDSNSDPDGSSSLSDEDSFASIGEDEHDDEAYREGRNQIARQTLECAQSTRPRATRLKKGGINSRPLEFIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G6V0</accession>
    <name>A0AAD2G6V0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1965109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G6V0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042246652" description="EGF-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1965109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30369" checksum="A93D21C5359543A2" modified="2024-05-29" version="1">MNQRVFTALCALLTTANVCGVINQDSLDFGLNIFPTAVLDLDKANSTDTKCVTYNGKELCSTIDSCSKSNYVCYTLDGERGHHSCSLSGGCSCTATYDGESCDCSVNPMLPYKVYADIRCGTHSGPFDATKVVNLDSYTARCNVPAGLFYPSYTHDRPDGAICTDGRSGLAAMPRLAVDWKCPALETLTDDGGVMSRAFQPDRDCTCTAVFNDTECQSCEPCPSGYPGDFRVSCDGFFTDCHGTFSVWNGKGPQASSDGGVSYSAWDFVPLIALALITSILAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2G7V6</accession>
    <name>A0AAD2G7V6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CYCCA115_LOCUS21426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002225">
        <property type="protein sequence ID" value="CAJ1965835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2G7V6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF37">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE 5-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="137"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ1965835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="539" mass="61731" checksum="5F98D8FE79B1D5C3" modified="2024-05-29" version="1">MNSRHHHPRPWAANVDLYRKIPTDLLEGSREGSIFSYIALVMMVILFVAETSDFLGGKLETYLAMDVSGEDTRIRLNFNITMMDLKCDWAVIDIVSALGNTQNVSAHVTKWNTDGSGVRLGYRGRNRNQKDIDLYDSTVSETLEELHENGVDAVSLDTESFELYKKEHDYLFVDFYASWCSHCRDLAPTWETLAEVMIDAGEALGNEIPHPDDYSEEDYLRAKRMQMPVVIAKIDCVTNQKVCNEQEQIRAYPTLRLFVDGEPWKAGDYRGHRTITDMVEWLYYTEEKHKQLLDGGAEAVRTLHEAHSAARGRLDDHLKVKEDARWKNRKMDDKRRLHHDWVEEEHPGCQLVGHLLLDRVPGNFHILARSSSHDLAPHMTNVSHQVNSLTVGDPMAVHRVQTSYIKNLPDKLTGKIAPMNGNVYVTENLHEAYHHYLKVVPTQVDGLQIGARFLRAYQILPNSQLSYYRTDMVPEAKFAYDLSPIKVFYRKSNRRWYDYCTSLMAIVGGVFTVVGMLESSVEATVKATRRRRVANGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GAR8</accession>
    <name>A0AAD2GAR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS16064</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001903">
        <property type="protein sequence ID" value="CAJ1956081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002342">
        <property type="protein sequence ID" value="CAJ1967722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GAR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1956081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1967722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="272" mass="32525" checksum="8F4B14C6283EF159" modified="2024-05-29" version="1">MARKKKLRPGKGAIAEILTRFIKPEQPNPGSKHRSMVVLEEEDRDDNQRKIFRFYYDGDEERTLMWANHRYLNVLKEGNHLLLFGGPGEPRPPESKEPNIKWQFSKARRLLVEAVNKGEIVFNEDDEPQQDLKEIYASKPEYSEYLFEKFEERLNNIWIKTKEDKNRASDDLEFFEEFIDCNEVSYFNKDGTAQWQGSEAQEQARVDIAANAVFHFGYRHLFENNTLYHLNYTHEQFKAYVRQEISRKKYLHTVEVRALQKREKENKRQSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GBE9</accession>
    <name>A0AAD2GBE9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS23151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002370">
        <property type="protein sequence ID" value="CAJ1968248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GBE9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1968248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58634" checksum="63DB1B2697D6046F" modified="2024-05-29" version="1">MTEPLYSDFNGPNAKSNSQALLRGLYEGETADPYLVSFLDHCRRPEGLEDQPLEVDLEDHVSFWRKMGEHKGSKPHGLHNGHFKAGVAFNLLACCDTIFRSIPFATGFVPAQWCHLLNFAIEKKPGKIRVDLMRTIQMMNSELQANNKRVGKSAMAYAEKHNLIPKGQHGSHKRHQAIDLALTKRLTWDLLHLQRRPAGWISNDAKSCFDRIVHWVAIISLMRFGIQWRTLRSMFDTLMKSKHRVRTGFGDSDRVFTPPTLIPFQGCGQGNGAGPPIWVAISSILLGMMISKGFGFDFLMSISLAPLLADCFCFVDDTDVCQAAPSPDQSGESIVPEVAKALKWWSNGVRLTGGAIRPDKSFWYLIDFKWNARQGVWKFRRKGDFKPSLLPTMSEIAVELDDLDGTPVHLRWLEPDESAKTLGILMSPCTNRKAQLVVMQGKAKAWADQIQPSFLHQYNVLPLLRTTIQKTLEYPMALTFFSQQEWDQLLSPVLRAALPKAGICRNFPCAMVYAPLHSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GD64</accession>
    <name>A0AAD2GD64_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS23665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GD64"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1969358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="426" mass="45707" checksum="68D5FC65C7AE80F0" modified="2024-05-29" version="1">MTNASGLAASIRGSTESSTFDLGGQNVTTITNNITSAFQDPLPIQEMIRITFVTGAGKLGRQKYDADAAKAVTSALRDLGFEDDRGASCVKECAASFKLQHDTGKNLKTVVVFPRIQEDDAPASGDGTGSNQASTVPVIAKGSVEDLIVSTSNAVFKNMTKSKCPSWSEKKECMGALSNIKTMLEELDQKLVTGTPLTDGEQEFYDSVSSDSLDEKQGIVKDLMHSQVEEGGITSREKKQLLSQVSERLEKVSAELEEAEGKKAEKLNGMKAKLEARKEMLSGITPKPLPKLKHETEILTLRAELLSLSDVVDAAAGRLLSLKESKALARKEEVEEEIADFEQKSRGWFEDDESFEERVNSLQGVAASRPKKGAAKKPASKSHAPAWIATSSSTKKTQSKSKAGKSKNSGGAGGVFAAMMMDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2GDE1</accession>
    <name>A0AAD2GDE1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS24457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002515">
        <property type="protein sequence ID" value="CAJ1970439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2GDE1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1970439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="95" mass="10800" checksum="BB73B21D31FC9184" modified="2024-05-29" version="1">MAQWTTDVSKILDARTGDISWGKDEIPPQLMFDLESEDEEFKCNFNKLIKAEDVDNGTLQGTTETEDINAQNYVNMEIGLRQGQEGELQRAVVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JG77</accession>
    <name>A0AAD2JG77_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS10873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001716">
        <property type="protein sequence ID" value="CAJ1946863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JG77"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1946863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="127" mass="15024" checksum="3A0143E5F4042F7E" modified="2024-05-29" version="1">MLPGTSQKLCENDDISVLTKKEIIFHSFPTKWQDTFLQQKETIEDPNITLQMVKTYMQATKILSDNMHISKQHAREKPQHTEYTQNSRQGENPLEFLPIFYRGLLYPSCQKRDWDHNVWSASLRDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGL3</accession>
    <name>A0AAD2JGL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MalT-like TPR region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CYCCA115_LOCUS11243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001736">
        <property type="protein sequence ID" value="CAJ1947657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGL3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="MalT-like TPR region" evidence="4">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ1947657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="395" mass="44506" checksum="0C92810AA0401BCE" modified="2024-05-29" version="1">MKLGETHADTVKTFKDIGDVFFEEKNFEKAEGMYRKALDIMDDLPPDSADLMHVSQPLMVSLQIQGKLSEAIKIQKDVLSKLLQMHGEDHFQVATIYIGIANLLEDQNRLDDALQMLEKSIETCSRLQGMEDFDRTILGLSLDTKARLLQKQGDFEGAIEILNNVVVIYKETLGEMNLSTADAYETLSKAYLEQEMMDSCINAITKTLEIRRNLLGDDHPSTLQLLVTVEVLKRDKVAKALNEQGLTMKAQGDSDKAIQFFQEALDIYMKTFADHPSAITVYENLSAVKVEQGLLEDGIAASAEALKILRRSRGDDHDATKIRMDAHRSLLKRLLENRSYCDGPRYIFKRGKNAKVLNEQGLAMKAQGDSEKAIQFFQEAVDVYNETYSMPIIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JGV2</accession>
    <name>A0AAD2JGV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Short-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="4">1.3.8.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Butyryl-CoA dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CYCCA115_LOCUS11214</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43456"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57389"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:86160"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:43457"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="4"/>
    <dbReference type="EMBL" id="CAKOGP040001733">
        <property type="protein sequence ID" value="CAJ1947586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JGV2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016937">
        <property type="term" value="F:short-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000004">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="150"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="257"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAJ1947586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="413" mass="44545" checksum="71D9F4FE06875801" modified="2024-05-29" version="1">MFSRLSTNLTRRVALTARYGCRSITTHSQLPEEHKMIYDMCRKFADEELAPNAGEWDKKHEFPTDAIAQLAELGLMGINVPESMGGVGLDALSYAIVMEEISRGCASTGVICSAHNSLYLYPVVEFGTPEQHEKWVTPFAGGSESLQIGCFGLSEPGNGSDAGAATTTATRDGDDWIINGTKAWITNAYEASAAVVFATTDKSLKHKGISAFIVPNDAEGFSLGAKEDKLGIRASSTANLIMENVRISGDNLLGEEGQGFKIAMQTLDGGRIGVAGQGLGIASAAIDCAVNYALERTAFGKPIANFQMIQHKISEMVLARDSARLLTWRAAQMKDAGENYTREAAMAKLAASEAATMCAHQSIQILGGMGYVTEMPAERHYRDARITEIYEGTSEVQHLVISNDVLKEYKSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JI57</accession>
    <name>A0AAD2JI57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS13987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001825">
        <property type="protein sequence ID" value="CAJ1953352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JI57"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042163988" description="TNase-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1953352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36408" checksum="5A1DF35C691A1E3C" modified="2024-05-29" version="1">MKLNPISLVRLLISVSVFEKCQPLMTPDSIPMNYAFVQILSTNIIQSTPSSTSTSAIDGGSLLVSLNNANARVANYQKDGFQKDTVMRILDGNTIKLQKGGLVSIAGARFPIASSSNFQFSECYTYGPTYKLRQLVPAKTEVWVKTSGSKPQAIIFRQKDSLNVNQELVKSGFAKVKPISSEFEAYLDPLKLKSWEAEANRLGLGIFKQCDASVESSFVAEFEPLEYDVVTQWGNDGGKQIVKQKESTAIVPPRNPGDVRGCSDFETYEDALSWFEYYKPFYGDIGKLDRNGDGVPCPGLPHTSIREKYRMKKPLNQDPSTLTGRETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JIU7</accession>
    <name>A0AAD2JIU7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS14826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001859">
        <property type="protein sequence ID" value="CAJ1954231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JIU7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1954231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="110" mass="12800" checksum="C3592185900E0A27" modified="2024-05-29" version="1">MEEVKNPLQYDCIVQNIDLSQWDLQTLAYLCTIHSARGQHNNKKEVVFGNKLFSAWENKPNFQWPWCKGYSENFVDPPATESWEAAANKLLQICDGDWKLVEQRIRAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JJ06</accession>
    <name>A0AAD2JJ06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS15336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001869">
        <property type="protein sequence ID" value="CAJ1954744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JJ06"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="69"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="170"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1954744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="25933" checksum="D33F5CA1791EA6B7" modified="2024-05-29" version="1">MANVHGLFSGRNNDDSDEDDSNNRFVGGISDRGGGSGLAVEPNHGDAPNPDGIFQRAEQAGAADEAGEESRRTITMYRDGFVVDDGPYRRLDDPANAEFLRALATGRTPPELVEGVSGDITVGLVDKRTEEFVEAFRSFSGAGATLGASSAVQGNTVEAASLPAAVEVDAGRPSTSIAVRLPNGQRKVVKVNLDSSVLQVAASVRPHLGDDVTSFRLVSGFPPKPLEDFEATVEAAGLKGAQVQIQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JK27</accession>
    <name>A0AAD2JK27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS17179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JK27"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1958444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="299" mass="32494" checksum="7433C8419572A4DE" modified="2024-05-29" version="1">MSQIRTINHSASGASFQFHEFGATVISFKTSSNRECLFLSRDAKLDGSKAVRGGIPLVFPQFGQPDKSMPQHGFLRNNIWKIDESSAYDNESGAGISLTLNLKDVKNSRGGKWDENTKYDLVATFSINVEAAKMSTELSITNTGTAGEKFDFQTLQHTYFRVDDRAAYDLKQCYVKGLEGYAVFDQITNETSTVGADPIVLEGNVDRIYTPPSGKEVVSVNIGVGGGKVMKLTASGICDDSAIPVSCVVWNPYKEKAAAMSDFGNDQYEEMICVEPGLLGTTSLESGKSAKLTQVIELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKH7</accession>
    <name>A0AAD2JKH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKH7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051832">
        <property type="entry name" value="mTOR-Rac_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829">
        <property type="entry name" value="DEP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="383"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1959480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="706" mass="78951" checksum="539A8DACA0386F64" modified="2024-05-29" version="1">MLNRSPSDGSVDSGSSTSTALKLTKVGSHIKLETMDGSHHSLNDWKPQKPRRSVSSNDEVGFFGEDFAITYDDESSISVSEDGSFAMSENDCSVAVSEITEPSMWASFGSSSWNQSKSQDSVSLIYGTDAVEYIFDAENDKERETEARPLHDEFRSNDLPPVPVRRNLSSKEGQLVDKFTSGSTCDDGNCGPPRPPRRQSTSDLRPLGENGLSQTRRSSSSDLISLSSRSSNPSHLPIEHSTLNTPFLGGDGSIRTKWSSMSNLPLAAQTVSSRNNRCALSSLPQKSSNLQALLPCKPLRSDGLLEEEEIEISKICSRLKFASESDPSISSNAPPQSPRRSSYSSNVSKKSASVPEPNTLMNRARTFSSLCAVSTHSKRLKKYPNTFVGSEAIDLMLKHGLARTREDAVFLGHRFCKEYNLFHHVSFDHTFKDGNYFYRFTNGVKEDLSILPYTSLEELRTLGEKFSQSMGVTKHISLMKTYKKTFMGNRAVDHMIAKGYASTRIHAVFIGQRLLEELNLFRHVSDQCQFKDSSHLYRFVSEDNTDRPSLESKEAELASVMSSIRSRRRLSFNGSERTSSTRTTVPPPPTTGSPNNKRSMRVSFGNVYQRHFERCLECNPATTKGPSLGLGWGFYDVPPVSVDDSHMVQKSRYGFRVSRLCREFILETEWGYTKTDIRRATRANEKIRQNRKKSFNKVSVVRSFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKH9</accession>
    <name>A0AAD2JKH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WWE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS17796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001992">
        <property type="protein sequence ID" value="CAJ1959374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WWE" evidence="1">
        <location>
            <begin position="342"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="1">
        <location>
            <begin position="434"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="772" mass="83895" checksum="DCFE714F20ADFD62" modified="2024-05-29" version="1">MTQCQANNDDKAFDFPIDLVELSKQHVGFLQTLHQLGVTIQRPSPKSLQRYRDLWLPLVLANPRETIVPPADCAWLWHCHRLAPFRYTSYLKREFGNDCQMLEANPAFCFQWNSDEVYGGSLNMIENDMKAAAERTRSLWNQQYPEESFHLQVEASASQTLPYSEEKIDDGSLFLDGFDLLGSTDRQATFLWQVSGPRFASEEFLKEGAVQYYKFLKLRRTAEKSNTILVPTYQIDLMWHTHILSSLTGYFVDCKAIMGTTLNHDDSLNDRTDDGPLDRAFNDTKALWKKSYGEEYFVKGGMYRGEPPKGYYNISWCSRVCNEEAQIPLGPFLHMIGLQGASSTNPTGGAYDLDIVWAWKETASQMSKHPASSVAGDPSECWIKYDESANATLETAFKNQGGEGTCDLGNGYVVDFLENKQTKKATGYVREVQRIVNVKSALERPKVWCWKETQGQMGKHSSSAIYGNPSECWIKYDDTANSILESAYQAQGNNGETSPSKGYMVNFTTMKQTKIATGFQREVQRVDATNDAADAAANDATAYWTPLTGNAPDGSPGFVASAPKSKTRGVNANPFKQDYIFGRKADKVGYFHITTKEAYEILAMRMKLRILQKKSDIAMATCCGLCNVPKTMEDDLDKLETTEAVVKARAGAARPTGKIGLPPKYKNNRNVSNTHYSDTGIWYFPGEYYDCGGGCGGDSNIHISGGGDGNCGAGCGASGCGGAACGAAACGGTRLGDGGGGGGFFGDSGGGDFGGGGGGGCGGGGGGGGCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JKP8</accession>
    <name>A0AAD2JKP8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002003">
        <property type="protein sequence ID" value="CAJ1959524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JKP8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053038">
        <property type="entry name" value="RLP_Defense"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48064">
        <property type="entry name" value="OS01G0750400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48064:SF6">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="846" mass="94410" checksum="696B100B70927566" modified="2024-05-29" version="1">MNSTFNNNADENPQSSEGTYDGGSEGYECEIRQEDQPCHDQLPNVESYKAMMGIHRTKPSNKKAAGMIQTKIIEKLAKRIPATEIDKTDTSRRSMDPPEQYPDDWGGLMKDPSGETFTDDYYDEEDEGQRPDLVRNHTDDNDLESYSKPDHLSSTRIHQLCWRLCLLITISVLLAALGFAVIMMTSNMNGWSEGGNSDVRTGGFVQGETQQYLKVRNYLLNIGKLPYNRTYDNYDPDSIEAVQTTSEPQPLSRRELLFNDTSPQYLAAQWLAHGDDSFMPVPTNNQKGYNQRYAMAVIYFALGGKEWFRNYNFLSAGHICTWKEEYNLQAIAEASKSGINTELATLLGVHNNDDWKSSIGSSDQTIIHGVHDCVNDAEGNFFPKALYLPHNNLNGRIPDEIGILNELELLNVEFNPLVRGKLTGHLQELKYLRHLGLQFCNHEGHIPMWIPGLSQLQFLGLGANRFDGDIPYDIGLLSNLKVLGLDNMNVHGDLGMFAALSNLETLYLENTFIHGGISSVLLELWPKLVEIDVSSCDLTGTLPADLWDGVFPSLKVLDLHGNKIEGPIPSPPPQNLMSGESWELEYLALNQNQFTGMVPEKIAAFGKLKHLDISENSLSFQLPEKLGELTNLEYLIVGNNQFVESEVPKFLIELTELRELSVGQTNLVGTIPAFLEYLSHLEILDLHNNGLFGTLPTELSSLIELRHLILKGNDLSGDFPSQQLSELSHLEVLLVEQNQFHGTADAICDSDGGIAEFVADCGANDPSGSTRHRIGSNSTIPTRDGAVGDLIGGNFPSPDQTGIITCPCCSICCNVGDTSCHNWVRQEHMDTIWKYGYKKRRYSYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JL83</accession>
    <name>A0AAD2JL83_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002069">
        <property type="protein sequence ID" value="CAJ1960764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JL83"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1960764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="97" mass="10898" checksum="86DFDD32334247D3" modified="2024-05-29" version="1">MLTNQPEAVTKQQPILSIMTHSNNLKQLSSTRRPMSLDAALKTMPSPDFLPRALPRDDSPEGRRDFLVGILDEVLDILNEDIFDDDLDTKSDHGLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMA3</accession>
    <name>A0AAD2JMA3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS20488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002170">
        <property type="protein sequence ID" value="CAJ1964133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMA3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1964133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="107" mass="12589" checksum="4661F08704F94F32" modified="2024-05-29" version="1">MREEEYIEELKRIEEQVRKLRLDLEKEREKKAPVDRSPKDKKQKVRRQQTTSGKLSIGDRVRIANPNKGQESEGEVTGINRISGFVTVHARTQRIRRLAKNLDRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JMH9</accession>
    <name>A0AAD2JMH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS20842</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">Golgi stack membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CAKOGP040002202">
        <property type="protein sequence ID" value="CAJ1964885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JMH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF194">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041920747" description="Fucosyltransferase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="8">
        <location>
            <begin position="267"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1964885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="459" mass="51040" checksum="FC20CD3C3AA3E94C" modified="2024-05-29" version="1">MKKHAARIPSTIKIVLALSSIIALSLLFHSSSSGENINHTSHPHSNNSKNNGDSSNQKKTKYERNTENTAASTTAITHDDSSSSVVATSKHATITTSGSTAKPRLFTCGFDLWNFGQELFGDLLEEVGRFGETTTTAKPTSQDILLQGGLNGPCSQSPDEEFPGKVLFVHSEARTAEKHLINERFYQLGPTSSEHAEPFGNALSSLSTATTGGGAAAATSIMSTRALPMVTFGAIFWVSSTTREQRQWILDPKKRQGAPSQQNNDKRRREAVVFVVNRCGTFRKEAALEISKLLPIHQNPKCQNKIVGGRPAPQTHSTANFQAIPPNDWKPRNSYRENYQLYSKYKYCLVMENTATDNYITEKLFLAFMGGCLPIYWGTPDVFFLFSKDAFVFYDYEHDGKKAMEELEYLQQNETYYKEKMAQPILAYGNRSAEAYLSLAQDVGNGRLRSRIRNMLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JN61</accession>
    <name>A0AAD2JN61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS21909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002276">
        <property type="protein sequence ID" value="CAJ1966325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JN61"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="41839" checksum="BC3B262A5863ACFB" modified="2024-05-29" version="1" fragment="single">MLDLQTNYCKEVDYYPKTVSKAQDMLKFHMDVIKNPGVNLYQGKDQPNKGKGKPKDDKKKAACYVCDREDHMSPKCPDILLPGIQWERPDQYVDYGKKLNLNQIGATVPATIPATVPGTSPVPSIITGGTSSVTGSVNTPLQLAGTTGNQMMQVPSGMQLMQIPTQGGGTVTVPYSMNANGEIAFSGMQLSQQGFSGAQMCQGFDATPARTPQLVKTGYYDTSNVFHDTIKGKDENGNDVYLIPCPTGTTNVELQSDWHYASENEDLPDLATEADRGMQFIQSRRIERDPFGLLDHIIMDSGCTNTTSCNGELMHGLRQAEKELDMHTNVGSRVLDEEGFLGRFPPPVYYDEDGIANVLAMREMIAAGYRITMDTDFDNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JNK8</accession>
    <name>A0AAD2JNK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS22636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmodium circumsporozoite protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002314">
        <property type="protein sequence ID" value="CAJ1967148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JNK8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0748">Sporozoite</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="818"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="818"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="849"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="910"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="930"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1967148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1051" mass="112862" checksum="34C1967567E090F6" modified="2024-05-29" version="1">MRSQPTGSHAPDLKNKQNEEAVVIGGIESGDSKLNDKHRSSSSRRHSDERKSRRSSLEKGTSKKASYRSSSDRPPRNSGGASSRPSHGSNSKRRSSRHKHSSSSRRRLSKESSHRRSDKERGHYSRPSTYRSPLHSNESDEVVDTLYGKDNANDNKEKEKSSRGRSERAVNPGVEHISGKPSTADKDTKEKTKSARRSPKGASEPGVEHFSNSGSLATTTLYGDDDVDAKKAKAKVSRHDSEYTTSVPGVQQVPSDNISTKQSDTISTLYGKNESDAKAKAKASRSSSSEYASYPGADRVFSPSSNSIWEKAKASRQLVTPSTHTSNTKTDSTMTTLYGEDADAKAKARASRGSSEFGTNPGAKTVSLFTESSHSTTSTLYGSDADTKAKAKAFGGNGEYASNPGVQSVHTASNRDLAGSTSDNSVNITLYGNDAGTKNKARAALRSSAHCTNPGVESIARRLTMTSLTDSVGSMMAPDEQGENGFEAPVARRVSIGTTDSESSNSVPEHGMRSEAVDAVRLPNDLEASPRYGETSAKRVVDKTQKSRKKRICFFLLVLLFIGGGVVAWYFLSKNEGSESDDSQISSVNISDPTSAPSSQAVVSLDPIGTPGAENATTSPSGLTPINMVYERPSKSDCIAISLNQTIAGREEMENVDFGLDLEVVVVDDIIITEQLVQELLNAIQEKILPSLAGCNIFLDEVVESWRFVIFDAFVNGNVQREEKCQDGTLSARNCHLIFVELDLFLKGNVKFLDIIRLIGNEEENFSNHLGLSDQFLVVKMIRAESLTPTAAPTTMPSHVPSFTPSTFPTVQASANPTFLPSLSPTRIVSGQPTRSPTLTPSSQPSFVPSTALPSSDPSLSPSKVLSNSPSTRPSETPSSSPSSRPTVDPSVRPTNVPSAAPSVTPSVMASKSPTKSPSASPSGMPTRKPSSAPSTQPTSSPSKEPTRGPSAFPSSLPSVEPTGSYRLSATDRKCPYQHPDRLFKDSAVADIDECYNLCLSTPDCIAFSIGIGRNCGTLNCMGCKSTSTVEFETGFTVFMRWTRVLFHEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JPS6</accession>
    <name>A0AAD2JPS6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS23050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002358">
        <property type="protein sequence ID" value="CAJ1968026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JPS6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051455">
        <property type="entry name" value="Bact_solute-bind_prot3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30085:SF6">
        <property type="entry name" value="ABC TRANSPORTER GLUTAMINE-BINDING PROTEIN GLNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30085">
        <property type="entry name" value="AMINO ACID ABC TRANSPORTER PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1968026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="275" mass="30129" checksum="376D854A77EBADE3" modified="2024-05-29" version="1">MPFSRPAMNHVCDRTSGLIVSMDFGAYGDLGDRPVSGGHIERMNHSTRCPAAAIFNGPAKVDFVAVTNSEVFTGVKSGRIDVAAGRTRTLEREIKHSSSGGFAFDFSPPYFYDGMIVAGYEPHGRCAANLFFDETCADTLICVPELTTWLDAVAAMSSLQDYFVGTEQHTKEPLSLMHRSDDQQFSDLIRWIIYGLFNAEEKGIAKDTSIEMPTTNLFGSELTGIWQNSVRESGNYGEMFSRNLDGLVVRDGLNLLNRLDGPQLCASPGTAPSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JQ18</accession>
    <name>A0AAD2JQ18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS23670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002424">
        <property type="protein sequence ID" value="CAJ1969368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JQ18"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF76">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="477"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1969368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="683" mass="73736" checksum="9B17F34E8B6B5D6E" modified="2024-05-29" version="1">MNSNDDDVSSLGPSATADMVTHTTTVETATLVLPDDTLRPGDEFILQTTTEIAAATSDAPLQQGGGHVIHIEGIVDLDELRDLVPGIDEDEFATLLHTHQQANGDDDDDDDDEDNTTLLSTLFHLDEQSHLLGDIESEQQELEDVPVSADAFLETIANAMPPTEVSRANKTQTYETSNQAFLLSVPMTNASLASGEEQTLVLAMPEINESEPLIMEESEVQAGDLNEEGEEDDDEYHGFVDMVRQYSEYLPQIPSLPTDVQDVELVATHTIAEHTPSAEEKVDGEEEEEEEEEEHIAHLDLIVERKVPLIGYVILVVGLFALASVGAALDLQEGSVTATMKSYWRLQSTAICIFPIAVLSMAQTPKDKLEEQWSSLTRRDLYFDLPICAASYSLLTAAFVIALEKTNLANAFVLSNLASLVIICGKLALGIKVLLLEGTGAFIGLSGAVVCALAPPAVVVEATDRMLSTLTSNEEQIGDGIAFLCSLGTAMYLIKAKKLRYKMDLFVFMFLIFALASVFLLCYMIMTGEEIRISADPNVGLFGWTDLVPDRLPLELYMAIVCNIAGTTGYIAVMKYFDPVVITMVMLTEPAVATLLGILAGVEKLPVGQVIVGNAFVILGSIIVIASESKSTESIDATKAFTTVEDTGGTTVVRTPKLKPSHKSTTATAAGTDSSTNVIWKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2JQG7</accession>
    <name>A0AAD2JQG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7640 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS24437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002513">
        <property type="protein sequence ID" value="CAJ1970419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2JQG7"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056057">
        <property type="entry name" value="DUF7640"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF18">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24646">
        <property type="entry name" value="DUF7640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7640" evidence="3">
        <location>
            <begin position="650"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1970419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="835" mass="86865" checksum="69060359DF0638A8" modified="2024-05-29" version="1">MSSNDAVLFGSDEKAKAKSRSGSKASNPGVVAVSENADEVLFGKEKEKSKKYDRSSSKSSSRGSKKSKSGSSSRSRRNKSKGSRGSKHDEVLFGNDKDAKAKAKASRGSGASKPGVERVGDSGKARAGDKGFVADPVFQGADSKTKHSYSKPAPVHTSAMLINDKVIDPFAATMDPSEDGSSAEDKKTNRRNSNKKCIILVVILMLIAGGVGAFFALSGGKDSETPETAATNIPVSPGSATTAPVAGTGPPTGAPTTTVTLDNDDSPSDQVCEAIENNNRTITGPATAVTMNLALTFDVSAQSGLTDSMVEDLIGAIQEYFLPALAGCDSINRQLVIRGGNRALQGGNRDPSRRNIINAFVNPIAWDEPCENESGGNCQQFVAKLSVILREEVFYFELTKMLSDPFPMGELKSLLKLGQPFISIMARSLVVTTEPPVSAPVEAPVVMPNASPIEPTDAPVDASVPSPPAGGSSPTTSPSTDVPVDGSDPTTAPIDGPVPTPTTIPMPLPTLAPVSQPTGAPSRGPTKAPVVGPSPPPTPVPTPRPTPVPTPAPTPVPTPGPTPGPTPGPTPGPTPGPTPSPTPGPTPPPTNPPTNPPTKTPTPPPTLATPQPTRAPPPTREPTCYCQSNVIRPACDNTLFRVNIDGSCGACIGPKACTELAGPAGGEIHEKACVGIQSCYKASVDYVASNSCRGANACMSRRIDVGENSCIGDNACGKRARIYIGNESCLGTNSCAQPLLQNPEPLSYFLHGSCQCEKCCLCMNRVKSGRCNTLGECCQRDNPRLKVDGVKDDTELAADADMETIEAVDEKIDAVDDTEKVGNEILENVDGYWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PU83</accession>
    <name>A0AAD2PU83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CYCCA115_LOCUS11749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001752">
        <property type="protein sequence ID" value="CAJ1948715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PU83"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="95"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ1948715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="528" mass="55852" checksum="BE1102102234BD5C" modified="2024-05-29" version="1">MMMDESQVKSQSDSPQDSAGQTVKEMSYSSEGDFCDNDDASSHLVQERKRDRHVLILMALFIAAVIIGCIALVQQSGKGDAPLSGNERQNEPSRIIGGSQSYQNEFPYYVDTGDCGGALIAPKIVLSAAHCGTSKFSGNKVIVNGSKRGKAGTYGKLISWSRWVPHPGFAEAGRIGPINDFALYLLDEAVTGLPVSLSLNQDRSFPVDGSTVVALGTGVQNRGSQLVKGRDLHDVMLPVINAEECKDNLGSFFNTDVMMCAGATGRGICYGDSGGPLVVRNGNRHILVGVTSFLGNPQCAKFHKYDNVFARTSSAFHWIKSVVCDQWGEQADFCPGNPGATCTDKPGWTDRDGYNCQAYIYTEATGVPICEYHRDIPGAGGLTPVQACCVCNPNSHIKPAPTAGSCSDSLGWTDSNGYDCQAYVYTEATGVPICEYHRDIPGAGGLTPVQACCVCNYSTGQGSNANSPTNPTSSAGSCSDSPGWTDSNGYDCGAYASTEATGVPICEYHRDIPGAGGLTPVQACCTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUH0</accession>
    <name>A0AAD2PUH0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CYCCA115_LOCUS12526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001761">
        <property type="protein sequence ID" value="CAJ1950312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUH0"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="11">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ1950312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="117" mass="13046" checksum="892EE6E2C8544788" modified="2024-05-29" version="1">MVWPFCPSCHSTLIVDSTGAIMCNVCPYRSNLSEMTSIPSSTTYSADRPVPLWAKSDEEQAALKTSSEPVRATIEEPCPRCSCPEVGYYTVQLRSVDEGQTVFYECPTCKYTWSINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PUM2</accession>
    <name>A0AAD2PUM2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS13016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001781">
        <property type="protein sequence ID" value="CAJ1951322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PUM2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="362"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="611"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="776"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="956"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1951322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="1250" mass="141762" checksum="58E695E5EF4E1090" modified="2024-05-29" version="1">MKRGIRRKENSGQDTAIRKRRSGLIHDNPDDSETHLHERIVSDNSRGQVEGTVNDDSVSSSSSSSSGGFQSTGALHNFDSQSGVASEISTVVSNHSHESLSFIRGKALYNLAQEMDALVDEMELGDVANDEEGPMISGSISDDDLDNLQLELANADQEFGDMFDWDGKSIIVVEAESDLLGKVDNGRTDVLRDRAILAKMESSDFQPQSRAEPQDTNHHPSLISLDESTTSLKEDGTSTKARSSQHSELTRMESNDFQPPAHSAQAPEIHFAPVSLKESTEGLQEEYSRPRQQQNTAFRQLEEILTLVKEENRALKTEMDQMQQSRTSEEKEYGKSMQAVEDQVVVLMKRLQGKQVQHNSVVKQAKDERASLKRQLQNKAEQIQELSTQFQQKTKEEESRRQKLEMALATVQEDLEPVDSVTSDMVQELDGASSMGNSSSIHNTTRSWRDTDSWWAASPKKPTLLRKDSQLPVGIDKIPEALTINHILHMCQSPPKVSRLSPKYYDTPPDMIDEIRTRNEKAVQVLAELKTKVRHSKSAKKKKDFEGRSTPPALDYGQAEPALVNENVQELNENNDMLLYQFDQESDILNRQLSVQQEIIARLETKHKTIMENSRQRYSSYEIELSELKATYDEQLATFANENESLNQKLVNVTSTIDRLKSRHEQEITSLKLERHEIEEELLENSVSVSNPGFDRFKQENESLSKQLVQYNDALDKLRIRHEQEMKAHASGQIFLVEELKKLQSKYERTVGSFHRQKEILMRKLLEKERAISEIEVAKESTLKASKEEKQRLEEQLQELDERCTKMKKERAGLLQAQKKKFELISSQLKGLKAMRDMERSNAQKRINILEEKLQTIKSKRNVGQEGEYQMMSRNLEGSDTTYSNFKSDHEVAVEASDTSRSSCLDPMADEDDKVQETRIASAAGRKLKQQSFVGTRGIIVSLLSILIIWVIVRLMRSSIDERDSFNRKIEALQNEVKDWEMQDMANDVMNVELQHSLEETTSASMSHRQEAFRLAGQLDKLLVKYEALQQEHANYLDLYSEETSHDSLPRCFDSPTLSLAALFEAQLEGLIEQRGSIETQVQLLDAAATPVVTACLSAEAKSLEFQEESPSTFVEMSDSVVSQDNASVKFADSQATVFELSKAGLEAEFFLVENLAMLSQLEGFEKETLRDLPLFLRQGVSLATDMLDENFAALWISLSALQDDIKSQASFFRDRAATVVQDAASKLKNRLFPRHRRMIKSEEGVWLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW01</accession>
    <name>A0AAD2PW01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integration host factor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CYCCA115_LOCUS17237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1958560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW01"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13831">
        <property type="entry name" value="HU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="entry name" value="IHF-like DNA-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="DNA-BINDING PROTEIN HU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175:SF3">
        <property type="entry name" value="DNA-BINDING PROTEIN HU-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="IHF-like DNA-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1958560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14112" checksum="B92F703A2D666A1E" modified="2024-05-29" version="1">MLRLTALIRSAGSRLTNSNGIAPNNNTLRSMSDAVTTKKEIIEEISKNHDLTVAESGRILNTVLDTIVESVCDDKPVRLSKFGTFERFQSEGRNGRNPNTGAPLYIPPKKRIRFKPYSSFKGMANND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PW38</accession>
    <name>A0AAD2PW38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-fucose mutarotase</fullName>
            <ecNumber evidence="3">5.1.3.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CYCCA115_LOCUS17467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-L-fucose = beta-L-fucose</text>
            <dbReference type="Rhea" id="RHEA:25580"/>
            <dbReference type="ChEBI" id="CHEBI:42548"/>
            <dbReference type="ChEBI" id="CHEBI:42589"/>
            <dbReference type="EC" id="5.1.3.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.29" evidence="3"/>
    <dbReference type="EMBL" id="CAKOGP040001980">
        <property type="protein sequence ID" value="CAJ1959018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PW38"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036373">
        <property type="term" value="F:L-fucose mutarotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="entry name" value="RbsD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050443">
        <property type="entry name" value="RbsD/FucU_mutarotase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31690">
        <property type="entry name" value="FUCOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31690:SF4">
        <property type="entry name" value="FUCOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="RbsD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1959018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="161" mass="17325" checksum="622C7813B40A615E" modified="2024-05-29" version="1">MGLLKGIDPILTADLLWVLRAMGHGDRLAIVDCNFPAAQVAKSTVTGKDPIILTVPLPQAVSAICELLPLDYFEESSVFYMAPQDGVAMPPEGNAVIDELKSAIATVSSPDVSIAPVERFQFYEEAKKCFAIVQTLERRPYGNAILVKGVIGPDGKDLKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PXH9</accession>
    <name>A0AAD2PXH9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS22015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040002286">
        <property type="protein sequence ID" value="CAJ1966432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PXH9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1966432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="323" mass="37766" checksum="AF597FAA66409E65" modified="2024-05-29" version="1">MILLRRQVDYLKEFVAELGWYVHGYGHDTRSDHQSRTIEAIYLGPADNMQKGHKLYDLNTKREVTRPQIPVLPITDQVIKLVEAHAAEEGVTDLRTYSRRNGEIILDADLLAGVDPDELWDEDYVPADIEIPPVDDMNLRKNDAISDEELEELMKDAAEDILESRRIDDKRQHKYDEADRTVHRMLQIIKRRQEEDDEEDMDFVQDQQPESDIEMDIDDEELKDMIDEVARELDRLSQPIEEEIMFSVEDDDDDYEGEYDAEEIEELQEAEDELQVYPDEEDDVCAGVRFEEVPVLSTTDDSNKDKKRRTQSGRSFYSNGVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2PY60</accession>
    <name>A0AAD2PY60_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS1524</name>
        <name evidence="2" type="ORF">CYCCA115_LOCUS18020</name>
        <name evidence="3" type="ORF">CYCCA115_LOCUS24172</name>
        <name evidence="4" type="ORF">CYCCA115_LOCUS24174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000058">
        <property type="protein sequence ID" value="CAJ1928675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002007">
        <property type="protein sequence ID" value="CAJ1959599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002469">
        <property type="protein sequence ID" value="CAJ1970149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAKOGP040002469">
        <property type="protein sequence ID" value="CAJ1970151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2PY60"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1928675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1959599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ1970149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ1970151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="88" mass="10182" checksum="D475009CADBCBE37" modified="2024-05-29" version="1">MTAVHMSNRYRLLPIFEQGDGSHDSDIPWETSALSFESDNRVVEFKTLFQKLKGPLFWALADHGHAYEPRPAHPFNKDWREASKLSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CAE2</accession>
    <name>A0AAD2CAE2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CYCCA115_LOCUS367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1903046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CAE2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06173">
        <property type="entry name" value="MFS_MefA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43266">
        <property type="entry name" value="MACROLIDE-EFFLUX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43266:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAJ1903046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="515" mass="56813" checksum="1D5EB0CB5B3D9901" modified="2024-05-29" version="1">MNTSKGKNCPKNDEESAYDRTPLIDDETIRKSASVDEERDSYGTLPTPLIFPLLPSNETHKQRNGYSDYDDDLPGHEDNKEDSYIALLNRNRNLRFYIFSLLVTNCGEWLSYIASIDLIETKLASLNQESRTAVSILVLVRLLPNVIFSSLGGKLADKYDRRQLMLGLDVISAVVTLLFVVAYELQSIPIVYVASFAQQALCGLYQPSSYSIIPMLVNDDDKDLKKATTMQGLVWSAMQAFGAALSGFVVDALGVRTCFCLDAGTFVLSAFFIWMVRGEYRAVPKKEEGDTNFQPDPGHSTSYLDGVKYLFSSYFAALIFVKAFAGLAYGACDILNVVLSELGDDALSVDFKLGVMFGFVGIGCLIGPFVTEPFMDAERPVTLQLSCVLSFAVATIGYMGWCWGPPSFWILSGFAMIRSAGSSVLWINSSILLQKFSSTEMMGRVMSMDYAVALAAEALSAYLCGYLMDRYGLSFHQVVFGLVIISSVSTVFWFVYHFTGRGAKKYKATGTPNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCI2</accession>
    <name>A0AAD2CCI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000072">
        <property type="protein sequence ID" value="CAJ1929242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCI2"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="269" mass="29165" checksum="8260AE48F061AA48" modified="2024-05-29" version="1">MNQHAGVRFTLKKRTIRKSLDDVKISSYNSDFLSGLFADVAKITEMADSGSTKRSCPEPATTVAEQNTNLESPTKKRRTLLSSSVSRCNCSSYNLSDLATSHSTKAVIEESREVFLPSPTQPRFLANSIERNPLATVTQSGRQDSLAYQLDCVSGPECPKLSTENAAVVAFPNLPATVSDSSCAAGLTRGSQIKQGSSPEKQPYKESFGWFVDLDDHQRNEGHTVSSYSVFCPDLAFQAPTAPNATHNDAAVQWAKAADTVDDVLGDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCJ3</accession>
    <name>A0AAD2CCJ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1912446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCJ3"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042101284" description="STI1 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1912446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22850" checksum="4980CB7FA718C0D0" modified="2024-05-29" version="1">MISIKQLFKIFTLLACFVAIAVAKKEEEDPTGQAIKDLKLGMAGIKEAANNPELLAQLMQDLQNPELMAEAKKMMESPEYQKQMKQWANSADFKDAAKQATDFMKDPAKAAEMEAKMEHMMKVGADQLKANSGKTMEDAMAAMADPAVLSQMTQMIKDPSFQANLAQMAKDPTFKQYIDSLQDMMKDPSKRAQFEKLGAQIRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CCR8</accession>
    <name>A0AAD2CCR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000001">
        <property type="protein sequence ID" value="CAJ1916152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CCR8"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042186474" evidence="1">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1916152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="201" mass="22472" checksum="68692BD2D7DF5D07" modified="2024-05-29" version="1">MLKLSLLLLACSTPTTIGLTSPTNNNQVRRDFIGLLGGIGSFVLLPDSSSAASASQEQKDKDNIVKGYDRLQYLLDNWEKETTVCRTGQETTFGDRCERTPLKVMDYLGFKDIRDPLYKADLTMMRLKNLVPDDREGDFYEAMEVFNQNAEEASSMAFISSWGEANPGGGKDRVQVFIERSKKNVIASRDSLKTVIDVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CDI6</accession>
    <name>A0AAD2CDI6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS1693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000080">
        <property type="protein sequence ID" value="CAJ1929478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CDI6"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1929478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="235" mass="26241" checksum="6383A0D360AB3BFC" modified="2024-05-29" version="1">MSLSISLDISSLLKTTALRKRKDILNSLHDFAITPRGKLEFDMLRESNKEFRLCTIALMPKAVVNQLSMADVSFSIPAHDLDESHRKQLNHLILNRTTFKDFIKRNSSEAFRKWLFVNASGDGGRDELLRQNDDSGGAHFVTLVKTDEQPDQSTPDTSETESDEDFFSFGSYGDADESDNQGIVALVTPTEEGNGTFDFETVAVSKPSTSYQPTREDLLRRDRKARPSASNKGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CES1</accession>
    <name>A0AAD2CES1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CYCCA115_LOCUS2880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000224">
        <property type="protein sequence ID" value="CAJ1932525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CES1"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ1932525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="482" mass="52942" checksum="0D894CF44F786740" modified="2024-05-29" version="1">MSDWSTLPPPEISAKQCQKLTDKYFEKGVPLAGRPMMIPFTKQAFLMGELQPVTTRNSESGNRTIEHVQVRPGKEKKLQILSTNDAKQWLLKKAQPALTKPPVTAPVTQKPTQSSTFAKQTQSQTSNNTSASPSSSKRSIPQSKSQQAAAPIPFHPTMVEIHEEFNEDGTQTKGDVVNVSSEFQALMDKIGQGDTMSFPQGTDMSGETKEEQPENGSDEEMITIDYDDTPQKQLSDPEYDQLAQRLDELARLEESENQRLQEGTSNSKLKAQRAAGNKKKNSSGSGGWNKGFLNQPKKNKSAQKRATTRTQSNSTKNSQSSGQAAAGTSSKSEVLPIPTSPESQIPQSTPAAETTPLPPATTGGVAFDLSQNQVQEIPSLPGTRPLPPRNNVSMPPNQAEPTVDETTRIMNSTAFSGVVQERPTVSVAPEGEQIQETNTIQERSAPPQSKFRRRRQQQQQMQQKPQDQSKKKLSRFAQERMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CF65</accession>
    <name>A0AAD2CF65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CYCCA115_LOCUS882</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 17">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000002">
        <property type="protein sequence ID" value="CAJ1920326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CF65"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="12">
        <location>
            <begin position="113"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="13">
        <location>
            <begin position="450"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAJ1920326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="70368" checksum="A66045557AAE8483" modified="2024-05-29" version="1">MKLHLTSTKPHLPRNSDNTRLFALQFIFHCFLTIFNNPAMAEQSSSYPEYTKEQLKEALNSLLEGSSNPDFDGRHLFGYKDANHQLSKLQSITATRILDYQNYIADNTSPSEEELKAKIPAFWKANGEILNLQKVIKGQSPRMALAAEFKRASPSKGDIGVHLDAGEQAQKYASAGANIISVLTEPRWFKGGLGDMTSVRLQTTNQSFPRPAILRKEFTTSKYQITEALAAGADTILLIVAVLPQHLLKDLIDHARSFGMEPLVEVHSDNEVEVALQAGAKVIGVNNRNLHTFQMDLHTTEHVADILKKQGCVFDHNDASAEYSICSLSGMSTAFDVDRYRKINVGMCLIGESLMRAADPKIAIANLCLDPKEFEKASSLVGGAYTKGTKIVKVCGVTNAEDAVVACRASANLIGVIFVPKSKRCVTKEQAKSVVEAVRVFGERTAQMKVSKTKQESALNQLLVNTRSLEDASRRPMVVGVFQNQSPEFIREMVKECGLDMIQLHGTEGMAAANEEICIVPAIRVVDIETDPETGKAAEGAAQTLLDAITSDPIAILLDTSIKGKKDGGGTGVTFDWGIAEKIQNAGLPVIIAGGLTPANIEEAVTSTRPWGVDVSSGVEASPGKKDHDKVKDFVSGARKAAIEASKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CH96</accession>
    <name>A0AAD2CH96_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CYCCA115_LOCUS4044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAKOGP040000368">
        <property type="protein sequence ID" value="CAJ1934705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CH96"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1934705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001295423"/>
        </source>
    </evidence>
    <sequence length="114" mass="12952" checksum="D6E51DF6189F6E95" modified="2024-05-29" version="1">MTASERKKAQSAMMLLAEKQFEKTIKGRLVYRGDGTREWLSREDTASPTASQEAITITCVIDAHEGREIMTLDVPNAFIQTYMPEAKEGEDRIYTKVTGMMVQTLIDMAPEYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAD2CHG9</accession>
    <name>A0AAD2CHG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CYCCA115_LOCUS3081</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cylindrotheca closterium</name>
        <dbReference type="NCBI Taxonomy" id="2856"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Ochrophyta</taxon>
            <taxon>Bacillariophyta</taxon>
            <taxon>Bacillariophyceae</taxon>
            <taxon>Bacillariophycidae</taxon>
            <taxon>Bacillariales</taxon>
            <taxon>Bacillariaceae</taxon>
            <taxon>Cylindrotheca</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2023-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Audoor S."/>
                <person name="Bilcke G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="CAKOGP040000225">
        <property type="protein sequence ID" value="CAJ1932926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAD2CHG9"/>
    <dbReference type="Proteomes" id="UP001295423">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
      
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